title: Neurosteroid modulation of dendrodendritic inhibition in the mouse olfactory bulb.
abstract: The present report describes neurosteroid modulation of olfactory bulb function by examining the effects of intrabulbar infusion of dehydroepiandrosterone sulfate (DHEAS), a neurohormone discovered in rat brain, on field potentials in the granule cell layer evoked by paired-pulse stimulation of the mouse lateral olfactory tract. Infusion of DHEAS (5 nmol) significantly decreased the test response without affecting the conditioning response. As a consequence, DHEAS selectively potentiated paired-pulse depression, which is believed to be due to granule cell-mediated inhibition of the mitral/tufted cells. The granule-to-mitral/tufted dendrodendritic synapse is GABAergic. Taken together, these results suggest that DHEAS potentiates the GABAergic dendrodendritic inhibition exerted by the granule cells on the mitral/tufted cells.
authors.affiliation: Department of Veterinary Physiology, Veterinary Medical Science, Kagoshima University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Usui
authors.forename: Y
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: H
authors.initials: H
authors.lastname: Kaba
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D019314:Dehydroepiandrosterone Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D003712:Dendrites / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects*; D007263:Infusions, Parenteral; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000187:drug effects / Q000502:physiology
chemical_list: D019314:Dehydroepiandrosterone Sulfate