Artoindonesianins A and B, two new prenylated flavones from the root of Artocarpus champeden.
Two new prenylated flavones, named artoindonesianin A (1) and artoindonesianin B (2), were isolated from the root of Artocarpus champeden, together with a known prenylated flavone, artonin A. The structures of artoindonesianins A and B were determined on the basis of spectral evidence (MS, 1H and 13C NMR) and by comparison with known related compounds. Compounds 1 and 2 exhibited cytotoxic activity against murine leukemia (P-388) cells.
Hakim
E H
EH
Department of Chemistry, Institut Teknologi Bandung, Jalan Ganeca 10, Bandung 40132, Indonesia.
Fahriyati
A
A
Kau
M S
MS
Achmad
S A
SA
Makmur
L
L
Ghisalberti
E L
EL
Nomura
T
T
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007214:Indonesia; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C119457:artoindonesianin A; C119459:artoindonesianin B