title: Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide.
abstract: BACKGROUND
  Chronic hypercalciuria can contribute to osteoporosis, particularly in men.
  
  
  OBJECTIVE
  To ascertain the effects of resolution of hypercalciuria on bone mineral density.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Referral service for metabolic bone disease in a tertiary-care teaching hospital.
  
  
  METHODS
  Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.
  
  
  METHODS
  Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months.
  
  
  METHODS
  Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.
  
  
  RESULTS
  Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.
  
  
  CONCLUSIONS
  Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.
authors.affiliation: Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA. adamsj@cshs.org
authors.forename: J S
authors.initials: JS
authors.lastname: Adams
authors.forename: C F
authors.initials: CF
authors.lastname: Song
authors.forename: V
authors.initials: V
authors.lastname: Kantorovich
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000652:urine*; D002908:Chronic Disease; D003404:Creatinine / Q000652:urine; D004232:Diuretics; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
chemical_list: D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D003404:Creatinine; D002118:Calcium