title: Effect of cimetidine on development of gastric cancer in rats after gastrojejunostomy.
abstract: OBJECTIVE
  To find out if cimetidine has an immunomodulating effect on gastric carcinogenesis in rats.
  
  
  METHODS
  Experimental prospective study.
  
  
  METHODS
  Teaching hospital, Norway.
  
  
  METHODS
  132 male PGV/Mol rats given gastrojejunostomies.
  
  
  METHODS
  Half the rats were given cimetidine in their drinking water postoperatively for a minimum of 38 weeks. They were killed after 52 weeks observation and the stomach was investigated macroscopically and microscopically.
  
  
  METHODS
  In the cimetidine fed group 19/48 animals developed cancer (49%), versus 12/43 (28%) in the control group (p = 0.24).
  
  
  CONCLUSIONS
  Cimetidine had no immunomodulatory effect on the development of gastric cancer in rats.
authors.affiliation: Department of Surgery, University of Bergen, Haukeland Sykehus, Norway.
authors.forename: G S
authors.initials: GS
authors.lastname: Hortemo
authors.forename: H
authors.initials: H
authors.lastname: Maartmann-Moe
authors.forename: O
authors.initials: O
authors.lastname: Rökke
authors.forename: A
authors.initials: A
authors.lastname: Viste
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D016009:Chi-Square Distribution; D002927:Cimetidine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D004383:Duodenogastric Reflux / Q000150:complications / Q000209:etiology; D005774:Gastrostomy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D007582:Jejunostomy; D008297:Male; D011446:Prospective Studies; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D006635:Histamine H2 Antagonists; D002927:Cimetidine