title: Mitral valve prolapse. Comparison between valvular repair and replacement in severe mitral regurgitation.
abstract: BACKGROUND
  The aim of this study was to analyse long term results of mitral valve repair of degenerative mitral regurgitation compared to valve replacement.
  
  
  METHODS
  A hundred-twenty-five consecutive patients with severe mitral valve insufficiency who underwent cardiac surgery from January 1987 to December 1995 were included in the study. Mean age was 55+/-16 years (77 males, 48 females). Mitral repair was performed in 62 patients and mitral valve was replaced in 63 patients. Mean follow-up was 5 years. The repair procedures were based on quadrangular resection of the posterior leaflet, chordal replacement and transposition. Annuloplasty was performed in 100% of cases. The technique of valve replacement was conventional with complete excision of the valve in the majority of cases.
  
  
  RESULTS
  Operative mortality following valve repair was 1.6%, no death occurred in the prosthesic group. In the repair group overall survival and re-operation rate were respectively 95.2% and 6.5%, while in the replacement group were 93.7% and 7.9%. No endocarditis and thromboembolic accidents were observed following valvuloplasty, while in the prostheses 6.3% of patients had endocarditis and 1.6% had a thromboembolic event. Mild or moderate left ventricular dysfunction was present in 5 patients after valvuloplasty and in 9 patients with prostheses.
  
  
  CONCLUSIONS
  Considering these results we conclude that, in patients with severe degenerative mitral insufficiency, mitral valve repair is warranted whenever it is possible. The advantages given by maintaining the native valve suggest that surgery should be considered in asymptomatic patients before the occurrence of the left ventricular dysfunction.
authors.affiliation: University Cardiology Division, Molinette Hospital, Turin, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Gramaglia
authors.forename: M
authors.initials: M
authors.lastname: Imazio
authors.forename: L
authors.initials: L
authors.lastname: Checco
authors.forename: M
authors.initials: M
authors.lastname: Villani
authors.forename: M
authors.initials: M
authors.lastname: Morea
authors.forename: M
authors.initials: M
authors.lastname: Di Summa
authors.forename: R
authors.initials: R
authors.lastname: Bonamini
authors.forename: E
authors.initials: E
authors.lastname: Rosettani
authors.forename: L
authors.initials: L
authors.lastname: Mangiardi
mesh_terms: D000368:Aged; D004697:Endocarditis, Bacterial / Q000209:etiology; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008945:Mitral Valve Prolapse / Q000150:complications / Q000503:physiopathology; D011183:Postoperative Complications; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D016277:Ventricular Function, Left