Leiomyoma of the round ligament in a postmenopausal woman.
OBJECTIVE
Leiomyoma of the round ligament of the uterus is a rare condition. We present the first case of a postmenopausal, previously hysterectomised, woman who received combined hormonal replacement therapy and developed a leiomyoma of the right round ligament.


METHODS
In sections of the tumor, immunohistochemical reaction with monoclonal antibodies against smooth muscle actin, desmin, vimentin, estrogen receptor and progesterone receptor was performed.


RESULTS
The leiomyoma showed bizarre histologic appearance in absence of mitotic figures and degenerative changes. Leiomyocytes presented a positive immunohistochemical reaction with monoclonal antibodies against smooth muscle actin, desmin vimentin and progesterone receptor in absence of estrogen receptor.


CONCLUSIONS
Progestin as part of a combined hormonal replacement therapy may play an important role in promoting the development of leiomyoma in hormonal responsive tissue of the round ligament in postmenopausal women.
Lösch
A
A
Department of Gynecology and Obstetrics, St. Pölten Hospital, Austria. aloesch@compuserve.com
Haider-Angeler
M G
MG
Kainz
C
C
Breitenecker
G
G
Lahodny
J
J
D003937:Diagnosis, Differential; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000209:etiology; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000175:diagnosis* / Q000209:etiology; D017698:Postmenopause; D011372:Progestins / Q000009:adverse effects; D012404:Round Ligament of Uterus
D011372:Progestins