Synergistic in vitro antimalarial activity of omeprazole and quinine.
Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.
Skinner-Adams
T
T
Department of Medicine, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia 6160, Australia. tskinner@cyllene.uwa.edu.au
Davis
T M
TM
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004357:Drug Synergism; D009853:Omeprazole / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology*
D000962:Antimalarials; D011803:Quinine; D009853:Omeprazole