Clinical and laboratory manifestations of anti-factor V antibodies.
Factor V is a large, multi-domain glycoprotein that exhibits both procoagulant and anticoagulant activity. Anti-factor V antibodies may develop by several mechanisms and, depending on their epitope specificity, may produce hemorrhagic or thromboembolic complications. The clinical laboratory is an essential component in diagnosing these antibodies, and therapeutic management depends on the predominant clinical manifestations.
Ortel
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Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D002417:Cattle; D005165:Factor V / Q000737:chemistry / Q000276:immunology* / Q000502:physiology; D006470:Hemorrhage / Q000276:immunology / Q000628:therapy; D006801:Humans; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000276:immunology; D013923:Thromboembolism / Q000276:immunology / Q000628:therapy
D001323:Autoantibodies; D005165:Factor V; D013917:Thrombin