Daidzein and genistein but not their glucosides are absorbed from the rat stomach.
Absorption of isoflavone aglycones and glucosides was compared in rats. Daidzein, genistein, daidzin and genistin were orally administered at a dose of 7.9 micromol/kg in 25 mM Na2CO3 and next their metabolite concentration in blood plasma was monitored for 30 min. After isoflavone glucosides administration, their metabolites appeared in plasma with a few minutes delay as compared to aglycones, which suggested that aglycones, but not glucosides, were absorbed already in the rat stomach. This observation was confirmed when absorption site was restricted solely to the stomach and absorption was shown to be independent of the vehicle pH used for administration.
Piskula
M K
MK
Noda Institute for Scientific Research, Noda City, Chiba, Japan. empi@food.irzbz.pan.olstyn.pl
Yamakoshi
J
J
Iwai
Y
Y
D000042:Absorption; D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D019833:Genistein / Q000097:blood / Q000493:pharmacokinetics*; D005960:Glucosides / Q000097:blood / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007529:Isoflavones / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005960:Glucosides; D007529:Isoflavones; C040641:genistin; C013908:daidzin; C004742:daidzein; D019833:Genistein