title: [The effect of lymphocytapheresis on multiple sclerosis].
abstract: We studied the effect of lymphocytapheresis (LCP) on the expanded disability status scale (EDSS) clinical score, lymphocyte subsets and Interleukin-2 (IL-2) production by peripheral blood mononuclear cell (PBM) in 5 patients with multiple sclerosis (MS). The EDSS clinical score significantly decreased after LCPs (p < 0.05). PBM IL-2 production and CD 4/8 ratio significantly decreased (p < 0.05, p < 0.05), and the number of neutrocytes and CD 11 b+CD 8+ (%) significantly increased immediately after LCP (p < 0.05, p < 0.05). Down-regulation of PBM IL-2 production and CD 4/8 ratio and up-regulation of CD 11 b+CD 8+ may account for therapeutic effect of LCP on MS. However, similar changes were observed in patients with CIDP and MG during immunoadsorbent therapy (IAT). It is possible that down-regulation of PBM IL-2 production and CD 4/8 ratio and up regulation of CD 11 b+CD 8+ and the number of neutrocytes may commonly result from apheresis therapy using extra-corporeal circulation.
authors.affiliation: Morioka Red Cross Hospital, Iwate, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Munakata
authors.forename: K
authors.initials: K
authors.lastname: Utsugisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nagane
authors.forename: M
authors.initials: M
authors.lastname: Ukitsu
authors.forename: H
authors.initials: H
authors.lastname: Tohgi
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D007937:Leukapheresis; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*
chemical_list: D007376:Interleukin-2