title: Clinical trial of three 10% carbamide peroxide bleaching products.
abstract: BACKGROUND
  A profusion of commercial bleaching systems exists on the market today, but there are few clinical comparisons of these systems.
  
  
  METHODS
  In this study, three different commercial 10% carbamide peroxide bleaching systems were used by 24 patients in an overnight protocol for two weeks. Each patient used two of the bleaching products simultaneously in a side-by-side comparison.
  
  
  RESULTS
  The mean onset of tooth whitening was 2.4 +/- 1.7 days. Tooth sensitivity was the most frequent side effect, as 64% of the patients reported tooth sensitivity occurring after 4.8 +/- 4.1 days and lasting for 5.0 +/- 3.8 days. Although intrapatient differences were recorded for the three commercial 10% carbamide peroxide bleaching systems by the patients, there were no statistical differences in the time of onset of subjective tooth whitening and the onset, frequency and duration of tooth sensitivity among the three commercial bleaching systems when compared pairwise or independently (p < 0.05).
  
  
  CONCLUSIONS
  Selection of which bleaching product to use should be based on the concentration of the active ingredient, the viscosity of the product and other marketing features. Further research is needed to investigate the causes of tooth sensitivity and methods to reduce its severity and frequency.
authors.affiliation: Department of Restorative Dentistry, University of Toronto, ON.
authors.forename: L
authors.initials: L
authors.lastname: Tam
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000077463:Carbamide Peroxide; D003742:Dental Devices, Home Care; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010545:Peroxides / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D013997:Time Factors; D014070:Tooth / Q000187:drug effects; D014073:Tooth Bleaching / Q000379:methods*; D014098:Toothache / Q000139:chemically induced; D014508:Urea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D014783:Viscosity
chemical_list: D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea