Nausea and vomiting after laparoscopic gynecologic surgery: a study of the incidence and the effects of tropisetron prophylaxis.
We have studied the incidence of postoperative nausea and vomiting (PONV) and the effect of prophylactic tropisetron, a 5-HT3 antagonist, during the first 24 hr after elective gynecologic laparoscopic surgery. Thirty-two of 68 patients (47%) experienced nausea or vomiting some time during the observation period. Sixteen of these patients (50%) had their first emetic symptoms after discharge from the recovery room. We could see no difference in the frequency of PONV in the patients who were given prophylactic tropisetron 5 mg orally before anesthesia.
Jakobsson
J
J
Department of Anaesthesia, the Karolinska Institute, Danderyd Hospital and Sabbatsberg Närsjukhuset, Stockholm, Sweden.
Dahlgren
G
G
Oddby
E
E
Ryberg
G
G
D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D010535:Laparoscopy; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D016896:Treatment Outcome; D000077526:Tropisetron
D000932:Antiemetics; D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron