title: Combined surgical and immunotherapeutic treatment of patients with fourth stage colon cancer.
abstract: Sixty-five patients with the fourth stage colon cancer were subjected to the combined surgical and immunotherapy. The following conclusions are made: (1) surgical elimination of the bulk of tumor mass is a necessary prerequisite for effective immunotherapy; (2) vaccination with autological tumor cells accompanied with bacille bilié de Calmette-Guérin (BCG) as the adjuvant and with interleukin-2 as the immunostimulator effectively prevents metastasizing after successful surgery; (3) the vaccine must necessary contain living tumor cells adequately presenting tumor antigens; and (4) in some cases, immunotherapy causes undesirable autoimmune complications. They can be registered by corresponding inflammation control methods.
authors.affiliation: Department of Thorax Surgery, Medical Academy of Postgraduated Education, St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Tarasov
authors.forename: M V
authors.initials: MV
authors.lastname: Filatov
authors.forename: T V
authors.initials: TV
authors.lastname: Kisliakova
authors.forename: F S
authors.initials: FS
authors.lastname: Noskov
authors.forename: A V
authors.initials: AV
authors.lastname: Koloskov
authors.forename: V V
authors.initials: VV
authors.lastname: Stavrovietski
authors.forename: S B
authors.initials: SB
authors.lastname: Onikienko
authors.forename: V Z
authors.initials: VZ
authors.lastname: Kletchikov
authors.forename: I V
authors.initials: IV
authors.lastname: Lvov
authors.forename: E
authors.initials: E
authors.lastname: Yu Varfolomeeva
authors.forename: O P
authors.initials: OP
authors.lastname: Blizniukov
authors.forename: V V
authors.initials: VV
authors.lastname: Levina
authors.forename: M V
authors.initials: MV
authors.lastname: Kiselevski
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000276:immunology / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D051381:Rats; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D019496:Cancer Vaccines; D007376:Interleukin-2