Purpuracenin: a new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Annona purpurea.
Purpuracenin, a novel cytotoxic acetogenin and annaglaucin, a known compound, were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR spectral measurements. The absolute configurations of both compounds are presented. The new compound and annoglaucin exhibited potent cytotoxic activity in vitro against six human solid tumor cell lines.
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Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México.
Mata
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D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D008958:Models, Molecular; D015394:Molecular Structure; D010946:Plants, Medicinal; D012639:Seeds / Q000737:chemistry*; D014197:Trees; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C118554:purpuracenin