[Treatment of non-complicated Horton's disease].
Non-complicated giant-cell arteritis is defined by the absence of ischemic complications, a remarkable response to corticosteroid treatment, and the absence of corticodependence. It is the most common type of giant-cell arteritis. Treatment relies on corticosteroids (prednisone or prednisolone) at an initial dosage of 0.7 mg/kg/j. The median duration of treatment is 2 years, but many patients need a more prolonged course. Side effects are frequent, especially atherosclerosis and osteoporosis. There is no demonstrated efficiency of corticosteroid sparing agents such as hydroxychloroquine or methotrexate. Dapsone may be efficient, but is not indicated because of its serious side-effects.
Sailler
L
L
Service de médecine interne, CHU Rangueil, Toulouse.
Juchet
H
H
Arlet
P
P
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000139:chemically induced; D013700:Giant Cell Arteritis / Q000188:drug therapy*; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced
D000305:Adrenal Cortex Hormones