title: Increased serum CA 19-9 antibodies in Sjögren's syndrome.
abstract: A 67-year-old woman with a history of thyroiditis presented with recent intermittent epigastric pain and nausea. Hyperamylasaemia, oedema of the pancreas, and high serum levels of lipase and CA 19-9 were found. Xerostomia and dry eyes developed later, accompanied by an abnormal Schirmer's test. The diagnosis of Sjögren's syndrome was confirmed by increased anti-Ro and anti-La antibodies and the histological findings of parotid gland biopsy. Two additional cases of Sjögren's syndrome with elevated serum CA 19-9 are also described. These observations of elevated serum lipase and serum CA 19-9 in Sjögren's syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder.
authors.affiliation: Gastroenterology Unit, Hebrew University School of Medicine, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Safadi
authors.forename: M
authors.initials: M
authors.lastname: Ligumsky
authors.forename: E
authors.initials: E
authors.lastname: Goldin
authors.forename: Y
authors.initials: Y
authors.lastname: Ilan
authors.forename: Y S
authors.initials: YS
authors.lastname: Haviv
authors.forename: S
authors.initials: S
authors.lastname: Nusair
mesh_terms: D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D018395:CA-19-9 Antigen / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology*
chemical_list: D000906:Antibodies; D018395:CA-19-9 Antigen