New adsorption column (Lixelle) to eliminate beta2-microglobulin for direct hemoperfusion.
The Lixelle column is an adsorbent column used to eliminate beta2-microglobulin (beta2M) selectively from circulating blood of dialysis related amyloidosis (DRA) patients, which is used in combination with a dialyzer in series. The column has such a high capacity for adsorbing beta2M that the most intensive removal of beta2M has been possible. In clinical trials of the column, the obvious improvement of subjective symptoms such as decreases in the frequency of nocturnal awakening, the joint pain severity index, and the joint mobility index were observed. Hypotension has been the most frequent adverse event observed during treatment since the column was put on the market. It is very important to clarify the causes of both the efficacy and the side effects. A controlled prospective study is now in progress to clarify the efficacy more scientifically. The results will be published soon elsewhere.
Furuyoshi
S
S
Nakatani
M
M
Taman
J
J
Kutsuki
H
H
Takata
S
S
Tani
N
N
D000686:Amyloidosis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D002951:Citrates; D019343:Citric Acid; D006464:Hemoperfusion / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D007022:Hypotension / Q000209:etiology; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D000077559:Sodium Citrate; D012996:Solutions; D001613:beta 2-Microglobulin / Q000378:metabolism
D002951:Citrates; D012996:Solutions; D001613:beta 2-Microglobulin; D000077559:Sodium Citrate; D019343:Citric Acid