title: [Pathologic mechanisms of diseases caused by isocyanates--review of current knowledge].
abstract: During recent years in industrial countries, isocyanates have been one of the main causes of occupational asthma. The mechanisms of isocyanate-induced disorders are still unknown but recent evidence suggests immunological reactions, including cell-mediated immune responses. Immune responses to isocyanates may result in different illnesses, some of which represent cell- and/or antibody-mediated entities. In addition, irritative, toxic, and mutagenic effects may occur. This review summarizes current knowledge of the pathomechanisms, including immunological and nonimmunological (genotoxic and mutagenic) aspects of isocyanate disorders.
authors.affiliation: Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin (BGFA), Ruhr-Universität Bochum. raulf@bgfa.ruhr-universität-bochum.de
authors.forename: M
authors.initials: M
authors.lastname: Raulf-Heimsoth
authors.forename: X
authors.initials: X
authors.lastname: Baur
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D017953:Isocyanates / Q000633:toxicity*; D008171:Lung Diseases / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D009784:Occupational Diseases / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology
chemical_list: D017953:Isocyanates