[The effect of histamine H2 receptor blockers on reparative processes in the gastric mucosa of patients with gastric peptic ulcer].
OBJECTIVE
To investigate effects of histamine H2-receptor antagonists (cimetidine, famotidine) on proliferative activity of gastric mucosa of patients with acute gastric ulcer.


METHODS
We treated 74 patients (54 men and 20 women) with acute benign mediogastric ulcer at the age of 28-56 years. Group 1 consisted of 24 patients who received antacid; group 2--of 26 patients on 1 g/day cimetidine; group 3--24 patients who received famotidine 40 mg qPM. We assessed clinical efficiency of three-week therapy, grade of ulcer healing, proliferative activity of antral and fundic gastric epithelium and ulcer margin epithelium using autoradiography with 3H-thymidine.


RESULTS
Clinical efficiency of histamine H2-receptor antagonists was significantly higher than of antacid. Cimetidine and famotidine stimulate proliferative activity in the epithelium of ulcer margins.


CONCLUSIONS
The ability to stimulate proliferative activity of gastric mucosa makes H2-receptor antagonists an effective modality in acute gastric ulcer with low acid secretion.
Alekseenko
S A
SA
Timoshin
S S
SS
D000328:Adult; D000863:Antacids / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001345:Autoradiography; D001706:Biopsy; D002927:Cimetidine / Q000627:therapeutic use*; D015738:Famotidine / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D000863:Antacids; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D015738:Famotidine; D002927:Cimetidine