title: The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics.
abstract: The principle of superposition is an important tool for studying multiple dose pharmacokinetics. In this paper, the principle of superposition in the presence of noncompliance is formulated generally as a recursive formula. With this powerful tool, we are able to provide a simple proof under general conditions for the fundamental result that steady state AUC is equal to the single-dose AUC for any concentration curve. In another application of the principle of superposition, we establish the relationship between the steady state average concentration and patient compliance index.
authors.affiliation: Janssen Research Foundation, Titusville, New Jersey 08560-0200, USA.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: S P
authors.initials: SP
authors.lastname: Ouyang
mesh_terms: D019540:Area Under Curve; D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological; D010349:Patient Compliance