Chemistry of verongida sponges. 9.1 secondary metabolite composition of the caribbean sponge aplysina cauliformis
A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13 and 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity, and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.
Ciminiello
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Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy, and Istituto di Zoologia, Via Balbi 5, 16126 Genova, Italy.
Dell'Aversano
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Fattorusso
E
Magno
S
Pansini
M