title: Reduced mastication stimulates impairment of spatial memory and degeneration of hippocampal neurons in aged SAMP8 mice.
abstract: The involvement of reduced mastication in senile dementia was evaluated by examining the effect of cutting off the upper molars (molarless) on spatial memory and numbers of hippocampal neurons in aged SAMP8 mice. Molarless mice showed a decrease in both learning ability in a water maze and neuron density in the hippocampal CA1 region compared with control mice. These changes increased the longer the molarless condition persisted. The data suggest a possible link between reduced mastication and hippocampal neuron loss that may be one risk factor for senile impairment of spatial memory.
authors.affiliation: Department of Anatomy, 2nd Division, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500-8705, Japan. onozuka@cc.gifu-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Onozuka
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: S M
authors.initials: SM
authors.lastname: Mirbod
authors.forename: S
authors.initials: S
authors.lastname: Ozono
authors.forename: K
authors.initials: K
authors.lastname: Nishiyama
authors.forename: N
authors.initials: N
authors.lastname: Karasawa
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003704:Dementia / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology; D008409:Mastication / Q000502:physiology*; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D008963:Molar / Q000294:innervation / Q000601:surgery; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology*; D009475:Neurons, Afferent / Q000502:physiology; D013028:Space Perception / Q000502:physiology*