title: Roles of A- and D-type K channels in EPSP integration at a model dendrite.
abstract: We examined the roles of A- and D-type K channels in the integration of EPSPs, particularly EPSP reduction, in a model dendrite using a computer simulation program (NEURON), instead of conventional electrophysiological methods which present technical difficulties. We obtained two important results: (1) KD channels play a crucial role in every synaptic input event, and (2) KA channels affect reduction of the second EPSP only when the second synaptic input is applied with a short interval (<100 ms). These results suggest that KD channels, which have not yet been analyzed experimentally, play a major role in synaptic integration in dendrites by altering their cable properties.
authors.affiliation: Department of Neuroplasticity, Research Center for Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: R
authors.initials: R
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: E
authors.initials: E
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology*; D004594:Electrophysiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D008838:Microcomputers; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D015221:Potassium Channels / Q000145:classification / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D015221:Potassium Channels