title: Mivacurium in patients with intracranial pathology.
abstract: BACKGROUND
  The aim of this study was to evaluate the effects of mivacurium on the cerebrospinal fluid pressure (CSFP) in patients requiring muscle relaxation to facilitate mechanical ventilation and on the intracranial pressure (ICP) in patients undergoing neurosurgery.
  
  
  METHODS
  
  
  
  METHODS
  prospective study.
  
  
  METHODS
  ICU in a hospital and operating room in a neurosurgery department at University.
  
  
  METHODS
  12 patients, GCS 6-7, with a mean age of 62.6 +/- 6.2 were studied in ICU and 10 patients, ASA I-II, with a mean age of 58.6 +/- 6.4 were studied in the operating room.
  
  
  METHODS
  all patients received mivacurium as single bolus dose of 0.2 mg/kg i.v.
  
  
  METHODS
  Heart rate, SAP, DAP and MAP were recorded at different times. In ICU CSFP was measured via a catheter in lumbar subarachnoid space and in operating room ICP was measured via an intraventricular catheter. CPP was evaluated as the difference between MAP and ICP. Statistical analysis was carried out using ANOVA for repeated measures and Bonferroni "t"-test and a value of p < 0.05 was considered to be significant.
  
  
  RESULTS
  Mivacurium was found not to influence or to increase ICP or CSFP. No significant changes in cardiocirculatory parameters were recorded in all patients.
  
  
  CONCLUSIONS
  In conclusion, mivacurium can be considered a suitable and manageable neuromuscular blocking drug in the management of patients with intracranial pathology.
authors.affiliation: Anesthesia and Resuscitation Service, San Rocco Hospital, ASL CE/2, Sessa Aurunca, Caserta.
authors.forename: T
authors.initials: T
authors.lastname: Cafiero
authors.forename: S
authors.initials: S
authors.lastname: Razzino
authors.forename: P
authors.initials: P
authors.lastname: Mastronardi
authors.forename: B
authors.initials: B
authors.lastname: Mazzarella
authors.forename: P
authors.initials: P
authors.lastname: De Vivo
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D007427:Intracranial Pressure / Q000187:drug effects*; D007546:Isoquinolines; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D016343:Monitoring, Intraoperative; D003473:Neuromuscular Nondepolarizing Agents; D019635:Neurosurgical Procedures; D011446:Prospective Studies
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium