title: HIV protease inhibitors: advances in therapy and adverse reactions, including metabolic complications.
abstract: Protease inhibitors (PIs) effectively inhibit replication of the human immunodeficiency virus (HIV), and reduce mortality and prolong survival in patients with HIV infection. Newer PIs saquinavir (soft gelatin capsule) and amprenavir, as well as other PIs, may be effective when administered twice/day. Adverse reactions may occur, as well as metabolic complications and interactions between PIs and other drugs, including other PIs. The strategy of combining PIs is based on specific pharmacologic interactions among the agents.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0378, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Kaul
authors.forename: S K
authors.initials: SK
authors.lastname: Cinti
authors.forename: P L
authors.initials: PL
authors.lastname: Carver
authors.forename: P H
authors.initials: PH
authors.lastname: Kazanjian
mesh_terms: D004347:Drug Interactions; D015658:HIV Infections / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D019469:Indinavir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D008060:Lipodystrophy / Q000139:chemically induced; D019888:Nelfinavir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D019438:Ritonavir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D019258:Saquinavir / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir; D019888:Nelfinavir; D019258:Saquinavir; D019438:Ritonavir