title: Hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) for most patients is a terminal complication of chronic inflammatory and fibrotic liver disease. With regrettably few exceptions, treatment is largely palliative, and long-term survival is rare. However, the major causes of HCC worldwide are known and preventable. Hepatitis B and C exist only in man; the viruses have no known non-human reservoirs. Transmission of the viruses can be interrupted by vaccination against hepatitis B virus infection and improvements in medical techniques for hepatitis C, for which no vaccine has yet been developed.
authors.affiliation: Department of Internal Medicine, University of Nebraska Medical Center, Omaha 66198-2009, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Schafer
authors.forename: M F
authors.initials: MF
authors.lastname: Sorrell
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy; D002648:Child; D006509:Hepatitis B / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy; D016031:Liver Transplantation