title: [Induction of penicillin tolerance in therapy of neurosyphilis in penicillin allergy].
abstract: Pharmacologically or immunologically induced hypersensitivity to penicillin is frequent. Immunological, i.e., allergic, hypersensitivity reactions are among the most important side effects and can lead to severe and life-threatening reactions. All types of allergic reactions have been described secondary to penicillin therapy. Immediate type hypersensitivity reactions, the symptoms of which range from urticaria and angioedema to respiratory and cardiovascular symptoms, and finally to life threatening full anaphylactic shock are particularly dangerous. This case-report demonstrates that in a patient allergic to penicillin, in whom there is a vital indication to administer this compound, the drug can be given safely after tolerance induction.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
authors.forename: D
authors.initials: D
authors.lastname: Regele
authors.forename: F
authors.initials: F
authors.lastname: Ruëff
authors.forename: K
authors.initials: K
authors.lastname: Degitz
authors.forename: B
authors.initials: B
authors.lastname: Przybilla
mesh_terms: D000368:Aged; D018926:Anti-Allergic Agents / Q000008:administration & dosage; D003888:Desensitization, Immunologic / Q000379:methods*; D003875:Drug Eruptions / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007428:Intradermal Tests; D009494:Neurosyphilis / Q000188:drug therapy*; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D010400:Penicillin G