title: N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer.
abstract: N-Aroyl-, N-Arylsulfonyl-, and N-Aryl-S,S-dimethyliminosulfuranes have been synthesized and evaluated as potential dermal penetration enhancers. The title compound and Azone exhibit similar activities for permeation of hydrocortisone through hairless mouse skin.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta 30303, USA.
authors.forename: L
authors.initials: L
authors.lastname: Strekowski
authors.forename: M
authors.initials: M
authors.lastname: Henary
authors.forename: N
authors.initials: N
authors.lastname: Kim
authors.forename: B B
authors.initials: BB
authors.lastname: Michniak
mesh_terms: D000818:Animals; D051379:Mice; D008812:Mice, Hairless; D008954:Models, Biological; D012869:Skin Absorption / Q000187:drug effects*; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C119492:N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane; D013457:Sulfur Compounds