title: The last fifteen years of schistosomiasis in Venezuela: features and evolution.
abstract: Control of schistosomiasis in Venezuela has been a topic of major interest and controversy among the metaxenic parasitosis. A small area of transmission of approximately 15,000 km2 was thought to be eradicated some years ago. However, some epidemiological characteristics of our transmission area have limited the success on the way toward eradication. Since 1945, when the Schistosomiasis Control Program started, the prevalence in the endemic area has decreased from 14% in 1943 to 1.4% in 1996. Until 1982, the surveillance of active cases was based on massive stool examination. Since then, the Schistosomiasis Research Group (SRG) recommended the additional use of serologic tests in the Control Program and the selective or massive chemotherapy depending on serological and parasitological prevalence of each community. At present, the real prevalence is underestimated due to the fact that approximately 80% of the individuals eliminate less than 100 eggs/g of feces. Those persons could be responsible for the maintenance of the foci going on and therefore limiting the impact of the control measures. Efforts of the SRG are being oriented toward improvement of immunodiagnostic tests by using defined antigens (enzymes) and chemically synthesized peptides, derived from relevant molecules of the parasite, either for antibodies or antigens search. On the other hand, introduction of snail competitors has been a biological weapon in the control of the intermediate host in certain areas. However, the recent reinfestation of water courses by Biomphalaria glabrata, the increased prevalence in some areas, together with important administrative changes at the Control Program of the Minister of Health, have arisen new questions and doubts, challenging the eradication strategy proposed during the last decade.
authors.affiliation: Instituto de Medicina Tropical, Universidad Central de Venezuela, Caracas, 1041-A, Venezuela. alarconb@camelot.rect.ucv.ve
authors.forename: B
authors.initials: B
authors.lastname: Alarcón de Noya
authors.forename: C
authors.initials: C
authors.lastname: Balzan
authors.forename: C
authors.initials: C
authors.lastname: Arteaga
authors.forename: I
authors.initials: I
authors.lastname: Cesari
authors.forename: O
authors.initials: O
authors.lastname: Noya
mesh_terms: D006801:Humans; D015995:Prevalence; D012552:Schistosomiasis / Q000453:epidemiology* / Q000517:prevention & control; D013997:Time Factors; D014687:Venezuela / Q000453:epidemiology