title: Eukaryotic circadian systems: cycles in common.
abstract: Common regulatory patterns can now be discerned among eukaryotic circadian systems, extending from fungi through to mammals. Complexes of two distinct PAS domain-containing transcription factors play positive roles in clock-associated feedback loops by turning on classic clock proteins such as FRQ, PER and TIM. These in turn appear to act as negative elements, interfering with their own activation and thus giving rise to an oscillatory negative feedback loop. Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature.
authors.affiliation: Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. jay.c.dunlap@dartmouth.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Dunlap
authors.forename: J J
authors.initials: JJ
authors.lastname: Loros
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S K
authors.initials: SK
authors.lastname: Crosthwaite
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D004330:Drosophila / Q000502:physiology; D029721:Drosophila Proteins; D004777:Environment; D005057:Eukaryotic Cells; D005246:Feedback; D005656:Fungal Proteins / Q000502:physiology; D019476:Insect Proteins / Q000502:physiology; D008954:Models, Biological; D008957:Models, Genetic; D009491:Neurospora / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D056950:Period Circadian Proteins
chemical_list: D029721:Drosophila Proteins; C087405:FRQ protein, Neurospora crassa; D005656:Fungal Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; C096445:tim protein, Drosophila