Synthesis of [11C]salicylic acid and related compounds and their biodistribution in mice.
For in vivo measurement of the hydroxyl radical (.OH), we synthesized [11C]salicylic acid, [11C]O-acetylsalicylic acid and [11C]2-methoxybenzoic acid by carboxylation of 2-bromomagnesiumanisol using [11C]CO2. The radiochemical yield of [11C]salicylic acid, [11C]O-acetylsalicylic acid and [11C]2-methoxybenzoic acid calculated from trapped [11C]CO2 in a liquid argon cooled stainless tube was 7.3 +/- 1.6, 5.2 and 10.2 +/- 1.7% (decay corrected), respectively. The uptake of 11C tracers by mouse brain was 0.46, 0.32, and 0.46% dose/g tissue, respectively, at 10 min post injection and presented washout patterns thereafter.
Sasaki
T
T
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan. sasaki@pet.tmig.or.jp
Ogawa
K
K
Ishii
S
S
Senda
M
M
D000107:Acetylation; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D001241:Aspirin / Q000138:chemical synthesis / Q000493:pharmacokinetics; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000737:chemistry*; D062425:Hydroxybenzoate Ethers; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D012459:Salicylates / Q000138:chemical synthesis / Q000493:pharmacokinetics; D020156:Salicylic Acid / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D002250:Carbon Radioisotopes; D062425:Hydroxybenzoate Ethers; D019275:Radiopharmaceuticals; D012459:Salicylates; C081914:2-methoxybenzoic acid; D020156:Salicylic Acid; D001241:Aspirin