title: The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas.
abstract: Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 microg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils.
authors.affiliation: Department of Microbiology, Brigham Young University, Provo, UT 84602-5133, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Bodily
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoopes
authors.forename: B L
authors.initials: BL
authors.lastname: Roeder
authors.forename: S G
authors.initials: SG
authors.lastname: Gilbert
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: C L
authors.initials: CL
authors.lastname: Herald
authors.forename: D N
authors.initials: DN
authors.lastname: Rollins
authors.forename: R A
authors.initials: RA
authors.lastname: Robison
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D054713:Bryostatins; D002408:Catheters, Indwelling; D012777:Cottontail rabbit papillomavirus; D004334:Drug Administration Schedule; D005260:Female; D007262:Infusions, Intravenous; D015552:Injections, Intralesional; D007783:Lactones / Q000008:administration & dosage* / Q000494:pharmacology*; D018942:Macrolides; D010212:Papilloma / Q000188:drug therapy* / Q000821:virology; D011817:Rabbits
chemical_list: D000970:Antineoplastic Agents; D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1