Acute in vivo effect of octreotide acetate, a somatostatin analogue on the cellular function of gastric mucosa in the rat.
Somatostatin is known to suppress various cellular functions of the gastrointestinal tract. In the present study, octreotide acetate, a synthetic long-acting somatostatin analogue was tested for its effects on some cellular functions of gastric mucosa. Octreotide raised the gastric mucosal pH within 1 h after a single subcutaneous injection to rats at doses of 1-100 microg/kg bodyweight. Serum gastrin levels increased transiently at a dose of 10 microg/kg bodyweight but not at 100 microg/kg. Basal levels of serum gastrin were not affected, while famotidine-induced gastrin secretion was suppressed by octreotide at a single dose of 100 microg/kg. The increase in the intragastric acidity and histidine decarboxylase activity following pentagastrin treatment was significantly reduced by octreotide. These results suggested that this somatostatin analogue inhibits the function of not only the parietal cell and G cell but also the enterochromaffin-like (ECL) cell, resulting in intraluminal hypoacidity.
Motegi
M
M
First Department of Surgery, Gunma University School of Medicine, Maebashi, Japan.
Nagamachi
Y
Y
Kaneko
T
T
Matsuzaki
S
S
D000818:Animals; D019861:Enterochromaffin-like Cells / Q000187:drug effects; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D019863:Gastrin-Secreting Cells / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D010295:Parietal Cells, Gastric / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D006728:Hormones; D015282:Octreotide