title: [Rapid relief, with little risk: titration of morphine].
abstract: Several years after the introduction of morphine for pain control, its use in pediatrics is limited by the fear of side effects. "Titration" represents a new way of management with a faster pain relief, and low risk of narcotic induced complication, the doses of morphine being self limited to the minimal pain relieving dosage. It consists in administering small doses of morphine every few minutes (10 in intravenous treatment or 30 orally) until total disappearance of pain; the total amount necessary for four hours is the sum of the initial dose and all the additional doses.
authors.affiliation: Unité de diagnostic et de traitement de la douleur, institut Gustave-Roussy, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Mollet
authors.forename: E
authors.initials: E
authors.lastname: Pichard-Léandri
mesh_terms: D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D009020:Morphine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D013997:Time Factors; D017186:Titrimetry
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine