title: Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp.
abstract: Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The structural assignments of the new compounds were based on their spectral data, including 1D and 2D NMR. Biological studies revealed that compounds 2-5 exhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: Y C
authors.initials: YC
authors.lastname: Shen
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Sheu
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes