Cyclosporine A monitoring in children: abbreviated area under curve formulas and C2 level.
Cyclosporine A (CsA) is the most commonly used drug in organ transplantation. To evaluate exposure the gold standard is area under curve (AUC), but this is expensive and requires many blood samples. For this reason, abbreviated formulae have been developed in adults. Data in children are scanty. Formulae cannot be applied in patients taking CsA every 8 h. We tested the abbreviated AUC formula published for adults in renal transplant children on twice daily therapy and we propose a method, requiring three blood samples, for those taking CsA every 8 h. A very good correlation was obtained for both groups. Furthermore, we studied the correlation between CsA concentration 2 h after administration and AUC. A good correlation was found supporting the possible use of this parameter for monitoring CsA therapy.
Dello Strologo
L
L
Division of Nephrology and Dialysis, Bambino Gesù Children's Research Hospital, Rome, Italy.
Campagnano
P
P
Federici
G
G
Rizzoni
G
G
D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D002648:Child; D016572:Cyclosporine / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D016030:Kidney Transplantation; D008297:Male
D007166:Immunosuppressive Agents; D016572:Cyclosporine