Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.
Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the transition to heart failure. Such conditional mutant mice have normal cardiac structure and function, but during aortic pressure overload, these mice display rapid onset of dilated cardiomyopathy and massive induction of myocyte apoptosis versus the control mice that exhibit compensatory hypertrophy. Thus, cardiac myocyte apoptosis is a critical point in the transition between compensatory cardiac hypertrophy and heart failure. gp130-dependent cytokines may represent a novel therapeutic strategy for preventing in vivo heart failure.
Hirota
H
H
UCSD-Salk NHLBI Program in Molecular Medicine, Department of Medicine, La Jolla 920093, USA.
Chen
J
J
Betz
U A
UA
Rajewsky
K
K
Gu
Y
Y
Ross
J
J
Müller
W
W
Chien
K R
KR
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D017209:Apoptosis; D001696:Biomechanical Phenomena; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002470:Cell Survival; D050822:Cytokine Receptor gp130; D005318:Fetal Heart / Q000196:embryology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006333:Heart Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009206:Myocardium / Q000473:pathology; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology*
D015703:Antigens, CD; C494200:Il6st protein, mouse; D008562:Membrane Glycoproteins; D018121:Receptors, Cytokine; D050822:Cytokine Receptor gp130