title: Domestic aeroallergen exposures among infants in an English town.
abstract: A multicentre, prospective cohort study of childhood asthma was established in three European countries; the purpose of the project is the examination of factors which modify the relationship between allergen exposure in infant life and subsequent atopy and asthma. Dust samples were collected from the homes of 643 infants in a single town in the UK (the first cohort) and assayed for house dust mites (Der p 1) and cat allergen (Fel d 1) concentrations by enzyme-linked immunosorbent assay. A questionnaire with potential relevance to the development of atopy and asthma was completed. A wide variation in exposure to both allergens was observed. Carpeted, double-glazed or damp living rooms, and those sampled in the winter months, had higher levels of Der p 1, but these features did not predict Fel d 1 concentrations. Measures of high home occupancy were positively related to Der p 1 concentrations; and inversely with levels of Fel d 1, a finding which could not be explained by cat ownership. Homes in which one or more persons smoked had significantly lower concentrations of Der p 1, but not Fel d 1. There were no consistent differences in allergen levels between homes where one or more parent or sibling was either atopic or asthmatic. These findings indicate complex interactions among domestic, behavioural and seasonal factors and early allergen exposure in British children.
authors.affiliation: Dept of Occupational and Environmental Medicine, Imperial College (National Heart and Lung Institute), London, UK.
authors.forename: W
authors.initials: W
authors.lastname: Atkinson
authors.forename: J
authors.initials: J
authors.lastname: Harris
authors.forename: P
authors.initials: P
authors.lastname: Mills
authors.forename: S
authors.initials: S
authors.lastname: Moffat
authors.forename: C
authors.initials: C
authors.lastname: White
authors.forename: O
authors.initials: O
authors.lastname: Lynch
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: P
authors.initials: P
authors.lastname: Cullinan
authors.forename: A J
authors.initials: AJ
authors.lastname: Newman Taylor
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000032:analysis; D000485:Allergens / Q000032:analysis*; D000818:Animals; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D002415:Cats; D016009:Chi-Square Distribution; D015331:Cohort Studies; D015897:Comorbidity; D004391:Dust / Q000032:analysis; D004739:England / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology* / Q000209:etiology; D007223:Infant; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012044:Regression Analysis; D018570:Risk Assessment; D014505:Urban Population
chemical_list: D000485:Allergens; D004391:Dust