title: [Experience in long-term use of berodual in the treatment of patients with chronic obstructive bronchitis].
abstract: OBJECTIVE
  To study clinical efficiency of 12-month administration of berodual in chronic obstructive bronchitis (COB).
  
  
  METHODS
  The trial entered 33 patients with at least 2-year history of COB and forced expiratory volume per 1 sec (FEV1) not less than 45% of normal value.
  
  
  RESULTS
  The best response of clinical parameters and external respiration was observed throughout 3 weeks of berodual inhalations. Dyspnea and cough were cured by the end of the treatment in 40 and 26% of the patients, respectively. Exercise tolerance has improved, FEV1 has increased for the year from 71.9 to 79.1%.
  
  
  CONCLUSIONS
  Long-term berodual monotherapy is able to inhibit progression of bronchial obstruction and symptoms of COB.
authors.forename: E I
authors.initials: EI
authors.lastname: Shmelev
authors.forename: N G
authors.initials: NG
authors.lastname: Khmel'kova
authors.forename: D V
authors.initials: DV
authors.lastname: Nonikov
authors.forename: E M
authors.initials: EM
authors.lastname: Melent'eva
authors.forename: A F
authors.initials: AF
authors.lastname: Abubikirov
authors.forename: V L
authors.initials: VL
authors.lastname: Makarova
authors.forename: L A
authors.initials: LA
authors.lastname: Mazaeva
authors.forename: T I
authors.initials: TI
authors.lastname: Ushakova
mesh_terms: D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D004338:Drug Combinations; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D006801:Humans; D009241:Ipratropium / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D004338:Drug Combinations; C030809:fenoterol, ipratropium drug combination; D005280:Fenoterol; D009241:Ipratropium