title: Synthesis and biological evaluation of novel 2-deoxy-4-thio-imidazole nucleosides.
abstract: A study on the use of 3'-directing groups for the synthesis of imidazole 2'-deoxy-4'-thionucleosides led to varying alpha:beta ratios in the glycosylation reaction. The para-nitrobenzoyl group gave the optimum result in the glycosylation step; therefore, this protected thiosugar 10b was used for the synthesis of a series of novel 2'-deoxy-4'-thio-imidazole nucleosides which have been evaluated for antiviral activity in vitro.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Inguaggiato
authors.forename: M
authors.initials: M
authors.lastname: Jasamai
authors.forename: M
authors.initials: M
authors.lastname: Shah
authors.forename: D
authors.initials: D
authors.lastname: Hughes
authors.forename: M
authors.initials: M
authors.lastname: Slater
authors.forename: C
authors.initials: C
authors.lastname: Simons
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006031:Glycosylation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007093:Imidazoles; D009705:Nucleosides