title: Maternal peripartum complications associated with vaginal group B streptococci colonization.
abstract: The study was done to determine the risk of clinically diagnosed intra-amniotic infection (IAI) and postpartum endometritis (PPE) associated with vaginal group B streptococci (GBS) colonization. Pregnant women were enrolled in a cross-sectional, observational study from 1992 to 1996 in Houston (n=908), Seattle (n=2676), and Pittsburgh (n=4338). Swab samples were obtained from the lower vagina of participants at admission for delivery and inoculated into selective broth and onto blood agar media. At the combined centers, 2.9% of the women (231/7922) had IAI, and 2.0% (157/7922) had PPE. The risk of IAI was higher for women with heavy GBS colonization (odds ratio [OR], 2.0; 95% confidence interval [95% CI], 1.1-3.7) than for those with light colonization (OR, 1.2; 95% CI, 0.7-1.8). The risk of GBS-associated PPE was not influenced by density of colonization (OR, 1.8; 95% CI, 1.3-2.7). These findings provide further evidence that GBS is associated with maternal intrapartum complications.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee-Womens Hospital, Pittsburgh, PA 15213, USA. mak11+@pitt.edu; mkrohn@mail.magee.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Krohn
authors.forename: S L
authors.initials: SL
authors.lastname: Hillier
authors.forename: C J
authors.initials: CJ
authors.lastname: Baker
mesh_terms: D000328:Adult; D000650:Amnion / Q000382:microbiology; D004716:Endometritis / Q000382:microbiology; D005260:Female; D006801:Humans; D010414:Pennsylvania; D049590:Postpartum Period; D011247:Pregnancy; D011644:Puerperal Disorders / Q000150:complications* / Q000382:microbiology; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications*; D013292:Streptococcus agalactiae; D013781:Texas; D014623:Vaginal Diseases / Q000150:complications* / Q000382:microbiology; D014861:Washington