Angiotensin II and extracellular matrix homeostasis.
As a circulating hormone, endocrine properties of angiotensin (Ang) II are integral to circulatory homeostasis. Produced de novo its autocrine/paracrine properties contribute to biologic responses involving various connective tissues (e.g. extracellular matrix, adipose tissue, bone and its marrow). In this brief review, we develop the concept of extracellular matrix homeostasis, a self regulation of cellular composition and structure, wherein fibroblast-derived AngII regulates elaboration of TGF-beta 1, a fibrogenic cytokine responsible for connective tissue formation at normal and pathologic sites of collagen turnover.
Weber
K T
KT
Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia, USA. karl_t_weber@muccmail.missouri.edu
Swamynathan
S K
SK
Guntaka
R V
RV
Sun
Y
Y
D000804:Angiotensin II / Q000096:biosynthesis / Q000378:metabolism*; D002319:Cardiovascular System / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D008957:Models, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016212:Transforming Growth Factor beta; D000804:Angiotensin II; D003094:Collagen