Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex.
Tissue PO2 was measured in the primary visual cortex of anesthetized, artificially ventilated, normovolemic cats to evaluate the effect of small doses [1 g perfluorocarbon (PFC)/kg] of a PFC emulsion (1 g PFC/1.1 ml emulsion; Alliance Pharmaceutical, San Diego, CA) on brain oxygenation. The change in tissue PO2 (DeltaPO2), resulting from briefly changing the respiratory gas from room air to 100% oxygen, was measured before and after intravenous infusion of the emulsion. Before emulsion, DeltaPO2 was 51.1 +/- 45.6 Torr (n = 8 cats). Increases in DeltaPO2 of 34.0 +/- 26.1 (SD) % (n = 8) and 16. 3 +/- 8.4% (n = 6) were observed after the first and second emulsion infusions, respectively. The further increase in DeltaPO2 after the third dose (7.9 +/- 10.5%; n = 7) was not statistically significant. The observed increases in tissue oxygenation as a result of the PFC infusions appear to be the result of enhanced oxygen transport to the tissue.
Padnick
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LB
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208-3107, USA.
Linsenmeier
R A
RA
Goldstick
T K
TK
D000758:Anesthesia; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008839:Microelectrodes; D010101:Oxygen Consumption / Q000187:drug effects*; D014793:Visual Cortex / Q000187:drug effects / Q000378:metabolism*
D004655:Emulsions; D005466:Fluorocarbons