gp49B1 and its related family of counterregulatory receptors of the immunoglobulin superfamily.
Cross-linking of FcepsilonRI on mast cells elicits positive signal transduction cascades that lead to the release of a variety of proinflammatory mediators. Mouse mast cells also express gp49B1 on their surface, an immunoglobulin superfamily member that bears two immunoreceptor tyrosine-based inhibitory motifs in its cytoplasmic domain and inhibits FcepsilonRI-induced release of secretory granule mediators and the cysteinyl leukotriene, LTC4. gp49B1 belongs to a growing family of inhibitory receptors expressed in mouse and man. Thus, FcepsilonRI-induced mast cell activation is counterregulated by several receptors belonging to the same superfamily as FcepsilonRI itself.
Katz
H R
HR
Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA. hrkatz@mbcrr.harvard.edu
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D005803:Genes, Immunoglobulin; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D017455:Receptors, IgE / Q000276:immunology*; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology
D000954:Antigens, Surface; C489447:Gp49a protein, mouse; D007136:Immunoglobulins; C489448:Lilrb4 protein, mouse; D008562:Membrane Glycoproteins; D017455:Receptors, IgE; D011971:Receptors, Immunologic