The 301 to 314 amino acid residue of beta-tubulin is not a target epitope for serum IgM antibodies in chronic inflammatory demyelinating polyneuropathy.
Connolly et al. [Neurology 48 (1997) 243] reported that IgM M-proteins from three patients selectively binds to an epitope on beta-tubulin that consists of amino acids 301 to 314. We therefore investigated whether these 14 amino acid residues beta301-314 are the target epitope for serum IgMs in sera from 67 patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 50 with Guillain-Barré syndrome, 50 with motor neuron diseases, and 50 normal controls. IgM anti-beta301-314 antibodies were not restricted to nor were selectively associated with CIDP. We conclude that beta301-314 is not a target epitope for serum IgMs in CIDP.
Tagawa
Y
Y
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan.
Yuki
N
N
Hirata
K
K
D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000276:immunology*; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000097:blood / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D007249:Inflammation; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000276:immunology*; D014404:Tubulin / Q000737:chemistry / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D007075:Immunoglobulin M; D014404:Tubulin