HLA-DR expression is a significant prognostic factor in laryngeal cancer. A morphometric study.
HLA-DR antigen expression in tumour cells was investigated in 68 laryngeal carcinomas. The tissue sections were studied by a morphometric method using a computer image analysis system. Although the highest number of HLA-DR-positive cells was observed in the groups with the lowest clinical stage, these differences did not reach statistical significance. Analysis of survival showed a significantly different survival time of patients classified as HLA-DR positive (10% and more HLA-DR+tumour cells) compared to those classified as HLA-DR negative. There were no significant differences in survival times between patients with glottic and extraglottic cancers, or between patients with various grades of histological malignancy.
Sikorska
B
B
Department of Pathology, Medical University of Lódź, Poland.
Danilewicz
M
M
Wagrowska-Danilewicz
M
M
D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006684:HLA-DR Antigens / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis
D006684:HLA-DR Antigens