title: [Cutaneous immune and inflammatory reactions to Malassezia furfur].
abstract: Initiation and aggravation of several inflammatory skin diseases are associated with Malassezia furfur. These are divided into at least two groups. In one group including tinea versicolor and Malassezia folliculitis, the growth of Malassezia furfur directly triggers the development of the cutaneous lesions. In another group including atopic dermatitis, seborrheic dermatitis, and psoriasis, cutaneous lesions already developed by other mechanisms are aggravated by the growth of Malassezia furfur. Recent progress of molecular biology techniques revealed that Malassezia furfur is divided into at least seven species. Since their clinical and histological findings are quite diverse, their differences cannot be explained solely by the difference in antigenicity of each Malassezia. Instead, the cutaneous defense mechanisms against Malassezia furfur must be considered. In this article, we reviewed the mechanisms at three levels: 1) barrier functions of the uppermost layer of the skin, the stratum corneum, 2) cytokine production by epidermal keratinocytes, and 3) immune and inflammatory responses by infiltrating neutrophils and T cells.
authors.affiliation: Department of Dermatology, Tohoku University School of Medicine Seiryo-machi 1-1, Aoba-ku, Sendai 980-8574, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Terui
authors.forename: K
authors.initials: K
authors.lastname: Kudo
authors.forename: H
authors.initials: H
authors.lastname: Tagami
mesh_terms: D003881:Dermatomycoses / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D008290:Malassezia / Q000276:immunology*; D012867:Skin / Q000276:immunology