Synthesis, analysis and in vitro antibacterial activity of new metal complexes of sulbactam.
Complexes of copper(II), nickel(II) and iron(III) with beta-lactamase inhibitor sulbactam have been synthesized, characterized and identified by elemental analysis, IR and 1H NMR spectroscopy. These complexes have been then tested for their in vitro antibacterial activity in combination with ampicillin against various bacterial species.
Kostova
I P
IP
Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Changov
L S
LS
Keuleyan
E E
EE
Gergova
R T
RT
Manolov
I I
II
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003300:Copper; D005658:Fungi / Q000187:drug effects; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009532:Nickel; D013055:Spectrophotometry, Infrared; D013407:Sulbactam / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003300:Copper; D000667:Ampicillin; D009532:Nickel; D007501:Iron; D013407:Sulbactam