title: Increased levels of sister chromatid exchanges in military aircraft pilots.
abstract: Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-performance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SCEs (high-frequency cells, HFCs) revealed a significant difference between pilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no significant differences either between pilots and controls or between smokers and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibration. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man.
authors.affiliation: Centro de Genética Humana, Instituto Nacional de Saúde, Av. Padre Cruz, 1699, Lisboa Codex, Portugal. ins.cgh@insarj.pt
authors.forename: M J
authors.initials: MJ
authors.lastname: Silva
authors.forename: A
authors.initials: A
authors.lastname: Carothers
authors.forename: N
authors.initials: N
authors.lastname: Castelo Branco
authors.forename: A
authors.initials: A
authors.lastname: Dias
authors.forename: M G
authors.initials: MG
authors.lastname: Boavida
mesh_terms: D000328:Adult; D000401:Aircraft; D002453:Cell Cycle; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D008889:Military Personnel; D009622:Noise; D016273:Occupational Exposure; D011174:Portugal; D012016:Reference Values; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000097:blood; D014732:Vibration