title: Perfluorocarbon emulsion improves oxygenation of the cat primary visual cortex.
abstract: Tissue PO2 was measured in the primary visual cortex of anesthetized, artificially ventilated, normovolemic cats to evaluate the effect of small doses [1 g perfluorocarbon (PFC)/kg] of a PFC emulsion (1 g PFC/1.1 ml emulsion; Alliance Pharmaceutical, San Diego, CA) on brain oxygenation. The change in tissue PO2 (DeltaPO2), resulting from briefly changing the respiratory gas from room air to 100% oxygen, was measured before and after intravenous infusion of the emulsion. Before emulsion, DeltaPO2 was 51.1 +/- 45.6 Torr (n = 8 cats). Increases in DeltaPO2 of 34.0 +/- 26.1 (SD) % (n = 8) and 16. 3 +/- 8.4% (n = 6) were observed after the first and second emulsion infusions, respectively. The further increase in DeltaPO2 after the third dose (7.9 +/- 10.5%; n = 7) was not statistically significant. The observed increases in tissue oxygenation as a result of the PFC infusions appear to be the result of enhanced oxygen transport to the tissue.
authors.affiliation: Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208-3107, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Padnick
authors.forename: R A
authors.initials: RA
authors.lastname: Linsenmeier
authors.forename: T K
authors.initials: TK
authors.lastname: Goldstick
mesh_terms: D000758:Anesthesia; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008839:Microelectrodes; D010101:Oxygen Consumption / Q000187:drug effects*; D014793:Visual Cortex / Q000187:drug effects / Q000378:metabolism*
chemical_list: D004655:Emulsions; D005466:Fluorocarbons