title: Malignant tumors of the nose and paranasal sinuses: hospital of the University of Pennsylvania experience 1990-1997.
abstract: We reviewed our experience with sinonasal malignancies, which comprise less than 1% of all cancers, in order to determine the spectrum of disease and outcome after treatment. The medical records of 48 patients with sinonasal malignancies treated between 1990-1997 were reviewed for epidemiologic characteristics, tumor location and histology, treatment modalities, and tumor recurrence. Mean age was 58.5 years and 46% were male. Multiple sites of origin were common, including maxillary sinus (83%), ethmoid sinus (35%), and nasal cavity (40%). The histologic spectrum included squamous cell carcinoma (46%), adenoid cystic carcinoma (6%), and miscellaneous others (48%). Treatment included surgery and adjuvant radiotherapy (XRT) (58%), surgery alone (27%), XRT and chemotherapy (6%), surgery and chemotherapy (4%), and XRT alone (4%). Mean follow-up was 15 months (range 2-58). Recurrence was evident in nine patients (19%), 3 (33%) of whom had prior treatment before presenting to HUP. Of the six who recurred after initial treatment at HUP, five (83.3%) were treated with surgery and XRT and one (16.7%) was treated with surgery alone. Of the three that recurred after undergoing attempts at salvage (prior treatment and then treatment at HUP), one had received surgery alone followed by surgery and XRT, one had surgery and XRT followed by surgery and one had XRT followed by surgery alone. Our experience reveals surgery and XRT to be the modality of choice, particularly for advanced tumors, whereas surgery alone may be sufficient for small, well localized tumors. Neoadjuvant chemotherapy may offer improved local control; the future role of endoscopic surgery warrants further investigation.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Tufano
authors.forename: N A
authors.initials: NA
authors.lastname: Mokadam
authors.forename: K T
authors.initials: KT
authors.lastname: Montone
authors.forename: G S
authors.initials: GS
authors.lastname: Weinstein
authors.forename: A A
authors.initials: AA
authors.lastname: Chalian
authors.forename: P F
authors.initials: PF
authors.lastname: Wolf
authors.forename: R S
authors.initials: RS
authors.lastname: Weber
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D010414:Pennsylvania / Q000453:epidemiology; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D015996:Survival Rate