title: Free-flap transfer with a synthetic arterial pedicle.
abstract: In this study, a unilateral epigastric free flap was raised in 12 rabbits. After the arterial portion of the flap (the superficial femoral artery) was replaced by a 1-cm-long polytetrafluoroethylene graft with an internal diameter of 1 mm, the flap was revascularized by two conventional microvascular end-to-end anastomoses (graft to artery and vein to vein). At 3 weeks, all flaps were raised again and the patency of the polytetrafluoroethylene grafts was checked. All grafts, including the proximal and distal anastomoses, were harvested and processed for light and electron microscopy. All grafts remained patient, and all flaps survived the period of 3 weeks. At reexploration, the graft was completely covered with connective tissue. Light and scanning electron microscopy evaluation showed that the internal surface of the graft was covered by a fibrin layer, and that the ingrowth of neoendothelium had just started from both anastomotic sites. The use of small-diameter polytetrafluoroethylene grafts in a rabbit free-flap model was demonstrated to be a reliable alternative for pedicle elongation.
authors.affiliation: Microsearch Foundation of Australia, Sydney.
authors.forename: P K
authors.initials: PK
authors.lastname: Maitz
authors.forename: M
authors.initials: M
authors.lastname: Lanzetta
authors.forename: E R
authors.initials: ER
authors.lastname: Owen
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D008297:Male; D008855:Microscopy, Electron, Scanning; D011138:Polytetrafluoroethylene; D011817:Rabbits; D013524:Surgical Flaps / Q000098:blood supply*; D014654:Vascular Patency
chemical_list: D011138:Polytetrafluoroethylene