The degree of hepatic regeneration after partial hepatectomy in rats with peritonitis and the role of lipid peroxidation.
Bile accumulation in the peritoneal cavity after partial hepatectomy reduces hepatic regeneration. In 70% of hepatectomized rats with bile peritonitis, hepatic DNA synthesis showed a delayed initiation and diminished peak level. Because intraperitoneal bile significantly accelerated lipid peroxidation and decreased energy metabolism in the liver remnant, all hepatectomized rats with bile peritonitis died within 7 days. Subcutaneous administration of exogenous combined antioxidants SOD and catalase dramatically reduced lipid peroxidation and improved the survival rate. Although the slightly elevated serum endotoxin level in rats with peritonitis may play a role in the inhibition of hepatic regeneration, the result suggest that intraperitoneal accumulation of bile components may also directly accelerate lipid peroxidation in the liver remnant, inhibiting the hepatic regeneration.
Fukuhara
K
K
First Department of Surgery, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Suzuki
M
M
Unno
M
M
Rahman
M M
MM
Endo
K
K
Matsuno
S
S
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism / Q000502:physiology*; D001663:Bilirubin / Q000097:blood; D002374:Catalase / Q000494:pharmacology; D004731:Endotoxins / Q000097:blood; D004734:Energy Metabolism; D006498:Hepatectomy; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000378:metabolism* / Q000503:physiopathology; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D010529:Peritoneal Cavity; D010538:Peritonitis / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D013534:Survival
D000975:Antioxidants; D004731:Endotoxins; D011994:Recombinant Proteins; D002374:Catalase; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D001663:Bilirubin