Bordatella pertussis adenylate cyclase: a toxin with multiple talents.
Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin (CyaA) that is able to deliver its amino-terminal catalytic domain into the cytosol of eukaryotic cells. The novelty of the structural organization and conformational flexibility of the CyaA catalytic domain has opened up the way for exploiting this protein as a tool for several biological applications, including epitope delivery, protein targeting and characterization of protein-protein interactions.
Ladant
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Dept of Biochemistry and Molecular Genetics, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France.
Ullmann
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D037361:Adenylate Cyclase Toxin; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D001886:Bordetella pertussis / Q000201:enzymology* / Q000378:metabolism / Q000472:pathogenicity; D000939:Epitopes / Q000276:immunology; D006801:Humans; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014774:Virulence; D010566:Virulence Factors, Bordetella / Q000378:metabolism*
D037361:Adenylate Cyclase Toxin; D000939:Epitopes; D010566:Virulence Factors, Bordetella; D000262:Adenylyl Cyclases