[Rush desensitization to drugs: elements for protocol rationalization].
The need for some treatments that are without possible alternatives leads, for allergy or intolerance, to procedures of rapid re-introduction at increasing doses, under the term of rapid habituation (A.R.) which is different from specific immunotherapy. No postulated mechanism has been suggested. The successes reported in the literature are presented here. They raise a discussion on the indications, the rational and empirical elements and the preferable routes of introduction. The authors stress the need for biological studies of A.R.
Moneret-Vautrin
D A
DA
Médecine Interne-Immunologie et Allergologie Clinique-Hôpital Central, Nancy, France.
Kanny
G
G
Beaudouin
E
E
D000284:Administration, Oral; D000485:Allergens / Q000008:administration & dosage / Q000627:therapeutic use; D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control; D002985:Clinical Protocols; D003888:Desensitization, Immunologic / Q000379:methods*; D004334:Drug Administration Schedule; D004342:Drug Hypersensitivity / Q000628:therapy; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000628:therapy; D007275:Injections, Intravenous; D007277:Injections, Jet; D007279:Injections, Subcutaneous; D018448:Models, Immunological; D016896:Treatment Outcome
D000485:Allergens