Sporovexins A-C and a new preussomerin analog: antibacterial and antifungal metabolites from the coprophilous fungus Sporormiella vexans.
Sporovexins A-C (1-3) and 3'-O-desmethyl-1-epipreussomerin C (4) have been isolated from liquid cultures of the coprophilous fungus Sporormiella vexans (JS 306). The structures of these new metabolites were elucidated on the basis of MS and NMR analysis. Compounds 1 and 4 show antifungal activity against competitor fungi, as well as antibacterial effects.
Soman
A G
AG
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Gloer
J B
JB
Koster
B
B
Malloch
D
D
D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010226:Parabens / Q000302:isolation & purification / Q000494:pharmacology*; D013141:Spiro Compounds / Q000302:isolation & purification / Q000494:pharmacology*
C119554:3'-O-desmethyl-1-epipreussomerin C; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004852:Epoxy Compounds; D010226:Parabens; D013141:Spiro Compounds; C038193:4-hydroxybenzoic acid