Immobilisation stress induced analgesia in diabetic rats.
Stress is known to produce analgesia. The pain threshold is altered in diabetes. We studied the effect of 1 hr of immobilisation stress on pain threshold in male Wistar rats. The same effect was tested in streptozotocin induced diabetic rats. The pain threshold of tail flick, vocalisation and vocalisation after discharge increased in the control group after the stress procedure. Significant analgesia was also obtained in diabetic rats, for flick and after discharge pain threshold. However the vocalisation threshold was not altered, probably due to the antagonistic action of glucose on opiate receptor at the level of brain stem.
Mahajan
A S
AS
Department of Physiology, Maulana Azad Medical College, New Delhi.
Mishra
T K
TK
Chakrabarty
K
K
Chakrabarty
A S
AS
D000698:Analgesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001933:Brain Stem / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D007103:Immobilization; D008297:Male; D009292:Narcotic Antagonists; D017288:Pain Threshold; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D014828:Vocalization, Animal
D001786:Blood Glucose; D009292:Narcotic Antagonists; D013311:Streptozocin