Inhibitory effect of ND2001 on spontaneous multiple metastasis of NC 65 tumors derived from human renal cancer cells intradermally transplanted into nude mice.
The NC 65 tumor cell line derived from human renal cell carcinoma was selected from among nine human cell lines by determining the inhibition of invasion by ND2001 (sodium D-glucaro-delta-lactam) in vitro. The efficacy of this agent against these tumor cells was investigated in an experimental metastatic model of human tumors in vivo. Although ND2001 did not inhibit growth of NC 65 cells intradermally transplanted into male KSN mice (nu/nu), this agent inhibited multiple spontaneous metastasis.
Nakatsugawa
S
S
Department of Radiology, Nagoya University, Japan. shig@med.nagoya-u.ac.jp
Okuda
T
T
Muramoto
H
H
Koyama
K
K
Ishigaki
T
T
Tsuruoka
T
T
Hosokawa
M
M
Kobayashi
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma / Q000473:pathology; D005937:Glucaric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008207:Lymphatic Metastasis / Q000517:prevention & control; D008297:Male; D008545:Melanoma / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000637:transplantation
D000970:Antineoplastic Agents; C001845:D-glucaro-delta-lactam; D005937:Glucaric Acid