The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring.
We present three cases of blastic mantle cell lymphoma with an unusual initial manifestation in Waldeyer's ring with methods for differentiating it from other blastic neoplasms of the head and neck. All cases presented with a feeling of fullness in the area of the mass. Morphologically, the tumours were blastic with a high mitotic rate (three to nine per high power field). All were B-cell phenotype with coexpression of CD43. In all cases cyclin D1 and bcl-2 were positive and CD23 negative. Blastic mantle cell lymphoma occurring in Waldeyer's tonsillar ring may be mistaken for other high grade haematopoietic neoplasms. Immunohistochemistry and awareness of this type of lymphoma are helpful in differentiating it from other neoplasms.
Aguilera
N S
NS
Department of Hematopathology, Armed Forces Institute of Pathology, Washington D.C., USA. aguilera@afip.osd.mil
Uusafr
M
M
Wenig
B M
BM
Abbondanzo
S L
SL
D000368:Aged; D019046:Bone Marrow Neoplasms / Q000556:secondary; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D011247:Pregnancy; D013274:Stomach Neoplasms / Q000556:secondary; D014062:Tongue Neoplasms / Q000473:pathology*; D014067:Tonsillar Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D014328:Trophoblastic Neoplasms / Q000473:pathology*