Imaging technologies for assessing neuroprotection in glaucomatous optic neuropathy.
The confocal scanning laser ophthalmoscope and the scanning laser polarimeter are two new imaging devices that may be beneficial in the diagnosis and monitoring of glaucoma patients. For each of these instruments, the authors describe benefits and limitations with regard to imaging mechanisms, sensitivity, and clinical applications. In comparison with currently used tests for glaucoma, these instruments provide quantitative assessment of the optic disc and RNFL at the clinic visit, with reduced need for pupil dilation and clear media. They also show promise for improving the ability to monitor progression of glaucomatous optic neuropathy and might allow better assessment of the efficacy of a neuroprotective agent.
Weinreb
R N
RN
Glaucoma Center, University of California, San Diego, USA.
Zangwill
L M
LM
D003952:Diagnostic Imaging / Q000379:methods*; D005901:Glaucoma / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007834:Lasers; D018613:Microscopy, Confocal / Q000379:methods; D009412:Nerve Fibers / Q000187:drug effects / Q000473:pathology*; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D019721:Ophthalmoscopes; D009898:Optic Disk / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D012680:Sensitivity and Specificity
D018696:Neuroprotective Agents