In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs.
Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.
Akova
M
M
Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey.
Gür
D
D
Livermore
D M
DM
Kocagöz
T
T
Akalin
H E
HE
D017963:Azithromycin / Q000494:pharmacology*; D017347:Brucella melitensis / Q000187:drug effects* / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D015363:Quinolones / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*
D015363:Quinolones; D017963:Azithromycin; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin