[Buruli ulcer (Mycobacterium ulcerans infection); report from the International Congress in Yamoussoukro, Ivory Coast].
Mycobacterium ulcerans infection (Buruli ulcer) is the third important mycobacterial disease world-wide in immunocompetent humans, after tuberculosis and leprosy. M. ulcerans is an environmental mycobacterium which has now been recovered from water and soil in swampy areas, and transmission to man occurs presumably through minor skin traumas. Endemic foci are known throughout the world, predominantly in tropical rain forest areas. The clinical presentation varies between a papule, a nodule or an ulceration with typically undermined edges. Surgery is the only effective treatment. BCG vaccination has a moderate protective effect. An association with HIV infection has not been demonstrated so far. Poor communities, with limited access to health care, and especially children are affected. The medical and socioeconomic burden imposed by the disease is tremendous. During the last decade the incidence of the disease has increased dramatically, particularly in West Africa. Possibly this is connected with changes in the natural ecosystem. The Yamoussoukro declaration on Buruli ulcer, adopted July 6, 1998, is the basis of improvement of awareness, health education, treatment, and research on M. ulcerans infection. Support by the international community is urgently needed.
van der Graaf
W T
WT
Academisch Ziekenhuis, Interne Kliniek, Groningen. W.T.A.van.der.Graaf@int.azg.nl
Scherpbier
R W
RW
van der Werf
T S
TS
D000293:Adolescent; D000328:Adult; D000354:Africa, Western / Q000453:epidemiology; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire / Q000453:epidemiology; D005260:Female; D006293:Health Promotion / Q000379:methods / Q000458:organization & administration; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D019911:Mycobacterium ulcerans / Q000302:isolation & purification*; D014456:Ulcer / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*
D001500:BCG Vaccine