title: Management of patients with bipolar mood disorder and substance dependence.
abstract: Nine patients with bipolar mood disorder and concurrent substance dependence were treated in an 18-bed inpatient addiction unit over a 3-month period. A multidisciplinary team approach used a medicalized Minnesota model and stressed the establishment of a positive diagnosis and individualization of management strategies for each patient. Clinically significant affective symptoms that required acute psychiatric intervention developed in several patients during hospitalization. Manic symptoms developed in three patients during sedative withdrawal, requiring the team to differentiate manic symptoms from physiologic withdrawal; and two patients became severely depressed, requiring pharmacologic management and suicide-prevention strategies.
  
  
  CONCLUSIONS
  Our experience with the patients in this case series supports the contention that there is no simple, uniform approach to the substance-dependent patient with bipolar disorder. Treatment teams must be prepared to differentiate complex syndromes and to manage manic, depressive, and addictive behaviors.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: B
authors.initials: B
authors.lastname: Sutor
authors.forename: J A
authors.initials: JA
authors.lastname: Tinsley
authors.forename: R M
authors.initials: RM
authors.lastname: Morse
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications* / Q000534:rehabilitation*; D003937:Diagnosis, Differential; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D010348:Patient Care Team; D019966:Substance-Related Disorders / Q000150:complications* / Q000534:rehabilitation*; D013997:Time Factors