Liver disease as primary manifestation of multiple myeloma in a young man.
We report a 27-year-old man who presented with fatigue, moderate weight loss and progressive abdominal distension as primary manifestations of a light-chain multiple myeloma (MM). Liver scan showed an enlarged liver with multiple low attenuation areas. Liver biopsy revealed sinusoidal infiltration by small size cells identified as Kappa light chain-producing primitive plasma cells by immunohistochemistry. The patient responded to three courses of EDAP. Subsequently he received intensive therapy with busulfan/melfalan and a peripheral blood stem cell transplantation enriched for CD34+ cells from his HLA-identical brother. No acute graft-versus-host disease was detected. Now, 12 months after transplant, the patient is asymptomatic.
Solves
P
P
Servicio de Hematología, Hospital Universitario La Fe, Valencia, Spain.
de la Rubia
J
J
Jarque
I
I
Cervera
J
J
Sanz
G F
GF
Vera-Sempere
F J
FJ
Sanz
M A
MA
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*