title: Azelastine eye drops reduce conjunctival hyperresponsiveness to hyperosmolar glucose challenge in children with asymptomatic mite conjunctivitis.
abstract: Mite allergy is characterized by a continuous allergen exposure. Persistent inflammation is therefore always detectable; and during symptomless periods as well. It has been reported that mite allergic patients also present a nonspecific hyperreactivity to different stimuli, including hyperosmolar solution. Since azelastine was previously demonstrated to be able to reduce allergic inflammation, the aim of the study was to investigate the effects of the drug on nonspecific conjunctival hyperreactivity in mite-allergic patients. Twenty children with mite allergy were studied. A hyperosmolar conjunctival challenge was performed before and after azelastine eye drops or placebo treatment for a period of 2 weeks. It was found that patients treated with azelastine eye drops showed a significant reduction in nonspecific conjunctival hyperreactivity compared to the placebo group (p = 0.018). It was concluded that azelastine eye drops are able to reduce the nonspecific hyperreactivity present in subjects with mite allergy.
authors.affiliation: Department of Internal Medicine, Genoa University, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ciprandi
authors.forename: A
authors.initials: A
authors.lastname: Catrullo
authors.forename: M
authors.initials: M
authors.lastname: Tosca
authors.forename: P
authors.initials: P
authors.lastname: Cerqueti
authors.forename: C
authors.initials: C
authors.lastname: Mondino
authors.forename: G
authors.initials: G
authors.lastname: Passalacqua
authors.forename: G W
authors.initials: GW
authors.lastname: Canonica
mesh_terms: D000293:Adolescent; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000276:immunology; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008925:Mites / Q000276:immunology*; D009883:Ophthalmic Solutions; D009994:Osmolar Concentration; D010793:Phthalazines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D018926:Anti-Allergic Agents; D009883:Ophthalmic Solutions; D010793:Phthalazines; D005947:Glucose; C020976:azelastine