Granulomatous mycosis fungoides: report of a case with some histopathologic features of granulomatous slack skin.
We describe a case of granulomatous mycosis fungoides, tumor stage, mimicking sarcoidosis in an 82-year-old man with a 2-year history of skin disease. The final diagnosis was established after one of seven biopsy specimens showed a nongranulomatous histologic picture of patch-stage mycosis fungoides. Monoclonality was proven for the lymphocytic population by T-cell-receptor rearrangement studies. The unusually extensive granulomatous inflammation with huge giant cells surrounded by CD1a-positive cells in the other six biopsy specimens was suggestive of the histopathology of granulomatous slack skin, another rare granulomatous cutaneous T-cell lymphoma. Because both a clinical and histologic overlap between granulomatous mycosis fungoides and granulomatous slack skin have been reported in the literature, we conclude that they may belong to the spectrum of a single disease.
Metzler
G
G
Department of Dermatology, University of Tübingen, Germany.
Schlagenhauff
B
B
Kröber
S M
SM
Kaiserling
E
E
Schaumburg-Lever
G
G
Lischka
G
G
D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology; D008297:Male; D009182:Mycosis Fungoides / Q000473:pathology*; D012507:Sarcoidosis / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*