title: Cobalt-57 as a SPET tracer in the visualization of ischaemic brain damage in patients with middle cerebral artery stroke.
abstract: In PET studies we have shown the usefulness of cobalt radionuclides for the visualization and quantification of ischaemic damage in stroke. In the present study, we explored 57Co2+ as a SPET tracer. Uptake of radioactivity was estimated by using a cobalt enhancement ratio defined as the ratio of cobalt uptake in the affected region versus a similar volume in the non-affected contralateral side. Clinical status was assessed with the Orgogozo stroke score at the time of scanning and at least 60 days after admission. Nineteen patients (11 men, 8 women) with a middle cerebral artery stroke were examined with 57Co2+ SPET 0-30 days after stroke onset. Our investigations show enhanced cobalt uptake in the infarcted brain tissue in patients with a major stroke and little clinical improvement. There was a significant correlation between the cobalt enhancement ratio and the Orgogozo score at the time of scanning and discharge. Our results suggest that 57Co2+ SPET is suitable for determining the extent of (possibly calcium-mediated) damage in stroke and in the assessment of potential therapeutic interventions.
authors.affiliation: Department of Nuclear Medicine, University Hospital Groningen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Stevens
authors.forename: S
authors.initials: S
authors.lastname: Knollema
authors.forename: D A
authors.initials: DA
authors.lastname: Piers
authors.forename: C
authors.initials: C
authors.lastname: Van de Wiele
authors.forename: H M
authors.initials: HM
authors.lastname: Jansen
authors.forename: A E
authors.initials: AE
authors.lastname: De Jager
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
authors.forename: R A
authors.initials: RA
authors.lastname: Dierckx
authors.forename: J
authors.initials: J
authors.lastname: Korf
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging*; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging* / Q000209:etiology; D002536:Cerebral Arteries; D002561:Cerebrovascular Disorders / Q000150:complications / Q000000981:diagnostic imaging*; D003037:Cobalt Radioisotopes / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D003037:Cobalt Radioisotopes; D019275:Radiopharmaceuticals