Testicular changes due to graded doses of nicotine in albino mice.
Administration of graded doses of nicotine (0.2 mg, 0.4 mg and 0.6 mg/100 g body weight) for 15 days to the adult mice reduced the weight of testis, number of spermatocytes and spermatids, but increased the number of spermatogonia which may be due to reduced conversion to subsequent stages. There is a high cholesterol content and Sudanophilic lipid accumulation in the treated testis. The weight of accessory sex organs which is dependent on androgens produced by the testis is also reduced. These changes are brought because of the non-availability of pituitary gonadotrophins essential for initiation and completion of spermatogenesis and steroidogenesis in the testis due to the administration of nicotine, which being CNS depressor might have caused inhibition in the neural stimulus essential for release of pituitary gonadotrophins.
Reddy
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Department of Studies in Zoology, Gulbarga University.
Londonkar
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R
Ravindra
Reddy
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Patil
S B
SB
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors / Q000502:physiology; D007986:Luteinizing Hormone / Q000502:physiology; D008297:Male; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D012669:Seminal Vesicles / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000502:physiology
D018722:Nicotinic Agonists; D009538:Nicotine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol