Three-dimensional structure-function relationship of vitamin D: side chain location and various activities.
The various biological activities of side-chain mobility restricted analogs, four diastereomers at C(20) and C(22) of 22-methyl-1alpha,25-dihydroxyvitamin D3, were evaluated. The relationship between structure and the various activities of the analogs was discussed in terms of the active space region concept that we previously suggested.
Yamamoto
K
K
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Ooizumi
H
H
Umesono
K
K
Verstuyf
A
A
Bouillon
R
R
DeLuca
H F
HF
Shinki
T
T
Suda
T
T
Yamada
S
S
D000818:Animals; D001692:Biological Transport; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002117:Calcitriol / Q000737:chemistry* / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D002117:Calcitriol; D002118:Calcium