title: Chemotherapy-induced acral erythema (CIAE) with bullous reaction.
abstract: Chemotherapy-induced acral erythema (CIAE) is a cutaneous response to a number of different chemotherapeutic agents. It causes a symmetrical, painful erythema of both the palms and soles which is self-limiting. CIAE with bullous reaction has been reported in relation to methotrexate, but it has been more commonly associated with cytosine arabinoside. We describe a case of CIAE with bullous reaction in a patient treated for Hodgkin's disease with a number of chemotherapeutic agents. We discuss the differential diagnosis of this condition which includes eccrine squamous syringometaplasia and acute graft vs. host disease
authors.affiliation: Department of Dermatology, Royal Liverpool University Hospital, Liverpool, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Azurdia
authors.forename: R E
authors.initials: RE
authors.lastname: Clark
authors.forename: P S
authors.initials: PS
authors.lastname: Friedmann
mesh_terms: D000328:Adult; D003561:Cytarabine / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced* / Q000175:diagnosis; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000175:diagnosis; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000175:diagnosis; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D003561:Cytarabine