B-cell (CD79a+) lymphoma affecting the tarsal joint synovia in a sheep.
A lymphoma affecting the synovia was identified in both tarsal joints of an aged sheep. With a panel of cross-reactive antibodies specific for lambda and kappa immunoglobulin light chain, MHC class II, CD3, CD79a and the Ki-67 antigen, the neoplasm was classified as a B-cell lymphoma with uniform expression of surface membrane CD79a. This would seem to be the first report of a lymphoma affecting the synovia in a domestic animal, and the first use of the CD79a reagent on ovine tissue.
Pearson
G R
GR
Department of Pathology and Microbiology, University of Bristol Veterinary School, Langford, BS40 7DU, UK.
Day
M J
MJ
Main
D
D
Pawade
J
J
D000818:Animals; D015703:Antigens, CD / Q000032:analysis*; D017252:CD3 Complex / Q000276:immunology; D051925:CD79 Antigens; D003429:Cross Reactions; D017809:Fatal Outcome; D007147:Immunoglobulin Light Chains / Q000276:immunology; D019394:Ki-67 Antigen / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000662:veterinary*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology*; D013640:Tarsal Joints / Q000276:immunology*
D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; D007147:Immunoglobulin Light Chains; D019394:Ki-67 Antigen; D011947:Receptors, Antigen, B-Cell