Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS.
We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.
Weinshenker
B G
BG
Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA.
Hebrink
D
D
Wingerchuk
D M
DM
Klein
C J
CJ
Atkinson
E
E
O'Brien
P C
PC
McMurray
C T
CT
D002874:Chromosome Mapping; D014644:Genetic Variation; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D009154:Mutation; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*
D018124:Receptors, Tumor Necrosis Factor