title: Primary advanced gastric small cell carcinoma: a case report and review of the literature.
abstract: We report a 73-yr-old man with primary advanced gastric small cell carcinoma, pure type. A large, Borrman type I tumor was located from the cardia to the entire gastric fundus and upper body. Atypical cells showed a round nucleus, small nucleolus, dense to granular chromatin, and scant cytoplasm. The histological findings indicates an advanced stage and exposure to the gastric serosa. Mitotic figures were observed. There was a proliferation of a sheet-like, solid pattern, but no rosette-like, sqamoid, or glandular patterns. The neoplastic cells were positive for Leu-7 (CD57) and 123C3 (CD56, neural cell adhesion molecule, NCAM) on the surface membrane. We diagnosed this case as primary advanced gastric small cell carcinoma, pure type, and report that Leu-7 and 123C3 monoclonal antibodies are useful markers for gastric small cell carcinoma. The 32 previously reported cases of gastric small cell carcinoma are also reviewed.
authors.affiliation: Department of Surgery, Mito Saiseikai General Hospital, Ibaraki, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takaku
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Naoi
authors.forename: N
authors.initials: N
authors.lastname: Santoh
authors.forename: Y
authors.initials: Y
authors.lastname: Setsu
authors.forename: N
authors.initials: N
authors.lastname: Mori
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*