title: Dopamine D4 receptor polymorphism and idiopathic Parkinson's disease.
abstract: Patients with idiopathic Parkinson's disease (IPD) are described as having markedly decreased novelty seeking characteristics. Since recent publications suggest an association between the dopamine D4 receptor polymorphism and novelty seeking, we investigated this polymorphism in a group of 122 patients with IPD and 127 healthy control subjects. We found similar allele and genotype frequencies in both groups and no association with the age of onset of symptoms. Therefore, the dopamine D4 receptor polymorphism does not confer genetic susceptibility to IPD and cannot explain the decreased novelty seeking in IPD patients.
authors.affiliation: Department of Neurology, Innsbruck University Hospital, Austria. florian.kronenberg@uibk.ac.at
authors.forename: M F
authors.initials: MF
authors.lastname: Kronenberg
authors.forename: H J
authors.initials: HJ
authors.lastname: Menzel
authors.forename: G
authors.initials: G
authors.lastname: Ebersbach
authors.forename: G K
authors.initials: GK
authors.lastname: Wenning
authors.forename: E
authors.initials: E
authors.lastname: Luginger
authors.forename: M
authors.initials: M
authors.lastname: Gollner
authors.forename: G
authors.initials: G
authors.lastname: Ransmayr
authors.forename: G
authors.initials: G
authors.lastname: Utermann
authors.forename: W
authors.initials: W
authors.lastname: Poewe
authors.forename: F
authors.initials: F
authors.lastname: Kronenberg
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
chemical_list: C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4