[The evaluation of expression of T-lymphocytes and NK cell surface receptors in women with threatened miscarriage].
OBJECTIVE
Recent studies emphasise an important role of immunological mechanisms in pregnancy maintenance. Therefore, unravelling mechanisms regulating placentogenesis are critical to understanding the pathogenesis of recurrent spontaneous abortion.


METHODS
We studied 49 women with threatened abortion and 24 healthy pregnant women. In addition, we studied 17 women with the history of recurrent spontaneous abortion and 10 healthy nonpregnant women in reproductive age with the previous successful pregnancy outcome. CD3, CD45 RO, CD4, CD8, CD16 expression on peripheral blood lymphocytes were studied using flow cytometry.


RESULTS
We determined that there is significantly higher CD4 expression in pregnant recurrent aborters compared to control (p < 0.05). Pregnant recurrent spontaneous aborters, with the successful pregnancy outcome have significantly lower CD16 expression compared to those, who abort (p < 0.05).


CONCLUSIONS
Our studies may indicate that T cell and NK cell can be involved in the pathogenesis of pregnancy loss.
Jerzak
M
M
Zakładu Immunologii Klinicznej Akademii Medycznej w Lublinie.
Baranowski
W
W
Wierzbicki
P
P
Górski
A
A
D000033:Abortion, Threatened / Q000276:immunology*; D000293:Adolescent; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000276:immunology*; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology*
D011956:Receptors, Cell Surface