Severe anaphylactic reaction after primary exposure to aprotinin.
Aprotinin is widely used to prevent bleeding and reduce blood transfusions after open heart surgical procedures. Because it is a foreign protein, aprotinin has allergenic potential. We report a case of near-fatal anaphylactic reaction to primary aprotinin exposure in a child successfully treated using cardiopulmonary bypass support. The possibility of an allergic reaction must be considered whenever this drug is used.
Cohen
D M
DM
Department of Anesthesiology, Ohio State University College of Medicine and Children's Hospital, Columbus 43205, USA. cohend@chi.osu.edu
Norberto
J
J
Cartabuke
R
R
Ryu
G
G
D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy; D007611:Aprotinin / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans
D006490:Hemostatics; D007611:Aprotinin