title: Neuroendocrine responses to running in women after zinc and vitamin E supplementation.
abstract: OBJECTIVE
  The study was undertaken to determine whether acute supplementation with zinc or vitamin E would modify neuroendocrine responses to physiologic stress.
  
  
  METHODS
  Specifically, the effects of exhaustive running on blood glucose, lactate, ACTH, cortisol, growth hormone, prolactin, catecholamine, and interleukin 6 (IL-6) concentrations were determined in 10 eumenorrheic runners after supplementation with zinc (25 mg), vitamin E (400 IU), or placebo. Subjects ran at 65-70% of their VO2max, to exhaustion, on a treadmill during the follicular phase of their menstrual cycles over three cycles.
  
  
  RESULTS
  There were no significant differences associated with supplementation for any of the hormonal and metabolic measures. Exercise, however, significantly (P<0.05) increased plasma lactate, ACTH, prolactin, and catecholamine concentrations, all of which peaked immediately after exercise (POST). Plasma cortisol concentrations were significantly (P<0.05) elevated at POST, and a further increase was noted 1 h after exercise. IL-6 concentrations rose linearly throughout exercise and reached peak values at POST. Exercise-induced changes were transient in that all measures returned to baseline within 24 h.
  
  
  CONCLUSIONS
  Acute supplementation with zinc or vitamin E did not influence the effects of exhaustive running on metabolic and endocrine responses in women. The effects of chronic supplementation on neuroendocrine responses to exercise remain to be determined.
authors.affiliation: Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, and Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20814-4799, USA. asingh@mxc.usuhs.mil
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: D A
authors.initials: DA
authors.lastname: Papanicolaou
authors.forename: L L
authors.initials: LL
authors.lastname: Lawrence
authors.forename: E A
authors.initials: EA
authors.lastname: Howell
authors.forename: G P
authors.initials: GP
authors.lastname: Chrousos
authors.forename: P A
authors.initials: PA
authors.lastname: Deuster
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002395:Catecholamines / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D009490:Neurosecretory Systems / Q000502:physiology*; D012420:Running / Q000502:physiology*; D014810:Vitamin E; D015032:Zinc
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D015850:Interleukin-6; D014810:Vitamin E; D019344:Lactic Acid; D000324:Adrenocorticotropic Hormone; D015032:Zinc; D006854:Hydrocortisone