Effects of l-amphetamine on the central neurons of the snail.
The effects of l-amphetamine on the spontaneous firing of central neurons of African snails (Achatina fulica Ferussac) were studied electrophysiologically. The effects of dopamine, noradrenaline, d-amphetamine, and methamphetamine on the central neurons also were tested. The l- and d-amphetamines (0.3 mM) elicited bursting firing of action potentials in the RP4 neuron of the snail, whereas dopamine (0.3 mM), noradrenaline (NE, 0.3 mM), and methamphetamine (2 mM) did not. The bursting firing of action potentials elicited by l-amphetamine was decreased if potassium-free solution, sodium-free solution, or solution containing oubain (0.1 mM), a sodium pump inhibitor, was perfused. The results suggested that l-amphetamine did, and methamphetamine did not, elicit a sodium-dependent bursting firing of action potentials of the neuron.
Huang
S S
SS
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Chuang
Y C
YC
Chen
Y H
YH
Tsai
M C
MC
D000200:Action Potentials / Q000187:drug effects; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002490:Central Nervous System / Q000166:cytology / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D008094:Lithium / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008694:Methamphetamine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012908:Snails; D012964:Sodium / Q000378:metabolism; D014403:Tubocurarine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D000697:Central Nervous System Stimulants; D018738:Hexamethonium; D008694:Methamphetamine; D010042:Ouabain; D001285:Atropine; D008094:Lithium; D012964:Sodium; D011433:Propranolol; D000661:Amphetamine; D008274:Magnesium; D006220:Haloperidol; D011188:Potassium; D002118:Calcium; D003913:Dextroamphetamine; D004298:Dopamine; D014403:Tubocurarine; D009638:Norepinephrine; D011224:Prazosin