title: [A giant invasive thymoma made resectable by cisplatin + vincristine + doxorubicin + etoposide (CODE)].
abstract: A 39-year-old man experienced cough and dyspnea by right massive pleural effusion. A large tumor was found in the anterior mediastinum and it had invaded the chest wall all around. The diagnosis was invasive thymoma stage IV a by biopsy. His tumor was too large to be resected, so chemotherapy was planned. The tumor responded well to cisplatin + etoposide until day 7, but it relapsed immediately between doses. Hence, we administered cisplatin + vincristine + doxorubicin + etoposide (CODE) with G-CSF for its high-dose intensity. The tumor diminished in size, and the chest wall invasion almost disappeared. An operation was performed. We describe our experience with a case of invasive thymoma which responded to CODE.
authors.affiliation: Dept. of Pulmonary Diseases, National Sapporo Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Hosokawa
authors.forename: H
authors.initials: H
authors.lastname: Maki
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: H
authors.initials: H
authors.lastname: Isobe
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D016066:Pleural Effusion, Malignant / Q000188:drug therapy / Q000209:etiology; D013945:Thymoma / Q000188:drug therapy* / Q000473:pathology; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin