title: Status epilepticus: new concepts.
abstract: Generalized convulsive status epilepticus is a neurological emergency characterized by abnormally prolonged seizures. This review emphasizes recent developments that bear on our understanding of the pathophysiology and management of status epilepticus. Topics include GABAA receptor modulation during prolonged seizures, the role of genetics in susceptibility to status epilepticus, neuron-specific enolas, the Veterans Administration Cooperative Study Group trial comparison of various drug regimens, utility of the electroencephalogram in patient monitoring, emerging drug therapies and patient management in out-of-hospital settings.
authors.affiliation: Department of Neurology, University of California, San Francisco 94143-0622, USA. bka@itsa.ucsf.edu
authors.forename: B K
authors.initials: BK
authors.lastname: Alldredge
authors.forename: D H
authors.initials: DH
authors.lastname: Lowenstein
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002985:Clinical Protocols; D003422:Critical Care / Q000379:methods; D004334:Drug Administration Schedule; D004569:Electroencephalography; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D018079:Receptors, GABA / Q000502:physiology; D012640:Seizures / Q000503:physiopathology; D013226:Status Epilepticus / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
chemical_list: D000927:Anticonvulsants; D015415:Biomarkers; D018079:Receptors, GABA; D010751:Phosphopyruvate Hydratase