Apoptosis-inducing activity of polyphenol compounds derived from tea catechins in human histiolytic lymphoma U937 cells.
Polyphenolic compounds derived from tea catechins were examined for apoptosis-inducing activity in human histiolytic lymphoma U937 cells. (-)-Epigallocatechin gallate, theasinensin D, compound OH-5, theaflavin, and theaflavin digallate induced apoptosis as evidenced by DNA ladder formation, its inhibition by a caspase inhibitor, and chromatin condensation. Theasinensin D was the most potent inducer and the data suggest the importance of the number and three dimensional localization of their phenolic groups in this activity. These apoptosis-inducible compounds may be useful as a cancer chemopreventive and chemotherapeutic agent.
Saeki
K
K
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Sano
M
M
Miyase
T
T
Nakamura
Y
Y
Hara
Y
Y
Aoyagi
Y
Y
Isemura
M
M
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology*; D053938:DNA Fragmentation; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D020298:U937 Cells
D000972:Antineoplastic Agents, Phytogenic; D010636:Phenols; D013662:Tea; D002392:Catechin