Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease.
The authors report high intrathecal release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-alpha and IL-1beta was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.
Sharief
M K
MK
Department of Neurology, Guy's Hospital, London, England. m.sharief@umds.ac.uk
Green
A
A
Dick
J P
JP
Gawler
J
J
Thompson
E J
EJ
D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000134:cerebrospinal fluid* / Q000276:immunology; D007375:Interleukin-1 / Q000134:cerebrospinal fluid; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
D016207:Cytokines; D018836:Inflammation Mediators; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha