Effects of prenatal co-administration of phentermine and dexfenfluramine in rats.
Pregnant rats were infused with phentermine plus dexfenfluramine from days 3 through 17 of gestation. Control rats were either pair-fed or were fed ad libitum. There were no effects of prenatal drug treatment on number of offspring, their birth weights, or on their motor coordination assessed at 11 days of age. Mothers and pups were sacrificed 21 days postpartum. Drug-treated mothers, but not their pups, showed a reduced density of serotonergic axons in the hippocampus compared with controls. 25% of the pups from the prenatal drug group showed mitral valve thickening.
Bratter
J
J
Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
Gessner
I H
IH
Rowland
N E
NE
D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000009:adverse effects*; D001369:Axons / Q000737:chemistry / Q000187:drug effects; D020372:Dexfenfluramine / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006624:Hippocampus / Q000187:drug effects; D007260:Infusion Pumps; D008943:Mitral Valve / Q000002:abnormalities* / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010645:Phentermine / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000032:analysis
D001067:Appetite Depressants; D004338:Drug Combinations; D011985:Receptors, Serotonin; D010645:Phentermine; D020372:Dexfenfluramine