title: Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida.
abstract: Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 microgram/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 micrograms/ml. Oleanolic acid, alpha-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 micrograms/ml, respectively.
authors.forename: T S
authors.initials: TS
authors.lastname: Jeong
authors.forename: E I
authors.initials: EI
authors.lastname: Hwang
authors.forename: H B
authors.initials: HB
authors.lastname: Lee
authors.forename: E S
authors.initials: ES
authors.lastname: Lee
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Min
authors.forename: K H
authors.initials: KH
authors.lastname: Bae
authors.forename: S H
authors.initials: SH
authors.lastname: Bok
authors.forename: S U
authors.initials: SU
authors.lastname: Kim
mesh_terms: D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019685:Rosales / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000097245:Ursolic Acid
chemical_list: D002687:Chitin Synthase; D004791:Enzyme Inhibitors; D014315:Triterpenes; D000097245:Ursolic Acid