title: Anonymous oocyte donation performed exclusively with embryos cryopreserved at the pronuclear stage.
abstract: OBJECTIVE
  To evaluate the clinical outcomes of patients who participated in an anonymous oocyte donation program that used embryos cryopreserved at the pronuclear stage.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  A tertiary care reproductive medicine unit.
  
  
  METHODS
  Anonymous oocyte donors and their respective recipients.
  
  
  METHODS
  Oocyte donors underwent a standard controlled ovarian hyperstimulation protocol and transvaginal ultrasound-guided oocyte retrieval. Oocyte recipients underwent at least one programmed hormone replacement cycle with transcervical ET.
  
  
  METHODS
  Thaw survival, implantation, clinical and ongoing pregnancy rates.
  
  
  RESULTS
  Thirty-six oocyte retrievals resulted in one ET to date. The mean numbers of oocytes that were retrieved and normally fertilized were 18.2 and 11.6, respectively. Fifty-one embryo thaw-transfer cycles were performed, with an embryo thaw survival rate of 93.5%. The clinical and ongoing pregnancy rates per ET were 52.9% and 51%, respectively. The overall implantation rate was 28.7%. The percentage of oocyte retrievals that resulted in at least one ongoing pregnancy to date was 69.4%.
  
  
  CONCLUSIONS
  Anonymous oocyte donation can be conducted efficiently with the exclusive use of embryos cryopreserved at the pronuclear stage. This approach facilitates synchronization of the donor-recipient pair, eliminates the risk that recipients will begin hormonal therapy without embryo availability, and produces an acceptable ongoing pregnancy rate per oocyte donation.
authors.affiliation: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Damario
authors.forename: D G
authors.initials: DG
authors.lastname: Hammitt
authors.forename: T M
authors.initials: TM
authors.lastname: Galanits
authors.forename: S A
authors.initials: SA
authors.lastname: Stevens
authors.forename: D R
authors.initials: DR
authors.lastname: Session
authors.forename: D A
authors.initials: DA
authors.lastname: Dumesic
mesh_terms: D000328:Adult; D002970:Cleavage Stage, Ovum; D015925:Cryopreservation; D005314:Embryonic and Fetal Development; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D018587:Oocyte Donation / Q000379:methods*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D014463:Ultrasonography / Q000379:methods
chemical_list: D012739:Gonadal Steroid Hormones