Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats.
The objective of our study was to assess the feasibility of dynamic susceptibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats. A FLASH sequence and EPI were evaluated. Different doses of AMI 227 and Gd-DOTA were assessed. Mean signal intensity vs. time curves were plotted. Well-shaped curves of the first pass of the contrast agent were only obtained with Gd-DOTA. According to these results it appears difficult to assess tumor blood volume with USPIO dynamic susceptibility contrast imaging.
Loubeyre
P
P
Service de Radiologie, Centre Hospitalier Lyon Sud, Pharmacology Research Center, Center EA 643, France.
De Jaegere
T
T
Miao
Y
Y
Landuyt
W
W
Marchal
G
G
D000818:Animals; D003287:Contrast Media; D003911:Dextrans; D017352:Echo-Planar Imaging / Q000379:methods*; D005240:Feasibility Studies; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D006571:Heterocyclic Compounds; D006614:Hindlimb; D007501:Iron; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds; D010087:Oxides; D051381:Rats; D017208:Rats, Wistar; D012208:Rhabdomyosarcoma / Q000473:pathology*
D003287:Contrast Media; D003911:Dextrans; D006571:Heterocyclic Compounds; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; C097921:ferumoxtran-10; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D007501:Iron; D052203:Ferrosoferric Oxide