IL-10 expression is associated with the expression of platelet-derived endothelial cell growth factor and prognosis in oral and oropharyngeal carcinoma.
We investigated the expression of IL-10 in oral and oropharyngeal squamous cell carcinoma (SCC) specimens by an immunohistochemical technique. Of 58 SCC, 13 (22%) and 35 (60%) cases showed intense and moderate positive staining of IL-10, respectively. There was no association between the staining of IL-10 and clinicopathological features. However, the patients with intense staining of IL-10 had a significantly lower overall survival rate than those with moderate or negative staining of IL-10 (P = 0.019). In addition, the patients with intense staining of IL-10 had the highest score of platelet-derived endothelial cell growth factor (PD-ECGF), which is established as a poor prognostic indicator (P = 0.0105). These results suggested that IL-10 contributes to the clinical outcome of oral and oropharyngeal SCC.
Fujieda
S
S
Department of Otorhinolaryngology, Fukui Medical University, Yoshida, Japan. sfujieda@fmsrsa.fukui-med.ac.jp
Sunaga
H
H
Tsuzuki
H
H
Fan
G K
GK
Saito
H
H
D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D016753:Interleukin-10 / Q000032:analysis*; D008207:Lymphatic Metastasis; D008297:Male; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009959:Oropharyngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D012307:Risk Factors; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000032:analysis*
D016753:Interleukin-10; D013939:Thymidine Phosphorylase