[Treatment of Helicobacter pylori infections].
H. pylori infection is a very common infection of the human stomach, related to various diseases such as gastritis, ulcerative disease of the duodenum and stomach, mucosa associated lymphoid tissue lymphomas and gastric cancer. It is generally accepted that the majority of related diseases is curable once H. pylori infection is successfully eradicated. H. pylori eradication will only be achieved after administration of combination therapies including antibiotics and antacids. Resistance to metronidazole and clarithromycin is an emerging problem, leading to impairment of eradication efficacy, irrespective of the regimen administered. Eradication regimens consisting of three or four anti-H. pylori drugs are the most efficacious. Given the easy use and high convenience to the patients and the high efficacy, 1-week proton pump inhibitor (PPI)-triple therapy is preferred as the first-line therapy. Alternatively, bismuth triple therapy or the combination of antacids and bismuth triple therapy can be prescribed; however, these regimens are less convenient to the patients, the course is prolonged or the side effects occur more frequently compared with PPI-triple therapy.
van der Hulst
R W
RW
Afd. Gastro-enterologie, Academisch Medisch Centrum, Amsterdam.
van 't Hoff
B W
BW
van der Ende
A
A
Tytgat
G N
GN
D017291:Clarithromycin / Q000627:therapeutic use*; D002985:Clinical Protocols; D004351:Drug Resistance; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology
D054328:Proton Pump Inhibitors; D008795:Metronidazole; D017291:Clarithromycin