title: Sequence analysis of an amphioxus cosmid containing a gene homologous to members of the aldo-keto reductase gene superfamily.
abstract: To gain an insight into vertebrate genome evolution, we have analysed the organization of an approximately 40-kb genomic clone of an amphioxus (Branchiostoma floridae) cosmid library. Amphioxus is considered as being the last non-vertebrate relative to vertebrates. Sequencing and analysis of the above clone using three different exon prediction programs (Grail, GenScan, Mzef) have led to the identification of a gene of the aldo-keto reductase family as well as further exons that gave a significant database match to known genes.
authors.affiliation: Max Planck Institut für Molekulare Genetik, Ihnestr. 73, D-14195, Berlin (Dahlem), Germany.
authors.forename: A
authors.initials: A
authors.lastname: Boeddrich
authors.forename: C
authors.initials: C
authors.lastname: Burgtorf
authors.forename: F
authors.initials: F
authors.lastname: Francis
authors.forename: S
authors.initials: S
authors.lastname: Hennig
authors.forename: G
authors.initials: G
authors.lastname: Panopoulou
authors.forename: C
authors.initials: C
authors.lastname: Steffens
authors.forename: K
authors.initials: K
authors.lastname: Borzym
authors.forename: H
authors.initials: H
authors.lastname: Lehrach
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000449:Aldehyde Reductase; D000074408:Aldo-Keto Reductases; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002816:Chordata, Nonvertebrate / Q000235:genetics*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003360:Cosmids / Q000235:genetics; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment
chemical_list: D000429:Alcohol Oxidoreductases; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase