The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas.
Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 microg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils.
Bodily
J M
JM
Department of Microbiology, Brigham Young University, Provo, UT 84602-5133, USA.
Hoopes
D J
DJ
Roeder
B L
BL
Gilbert
S G
SG
Pettit
G R
GR
Herald
C L
CL
Rollins
D N
DN
Robison
R A
RA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D054713:Bryostatins; D002408:Catheters, Indwelling; D012777:Cottontail rabbit papillomavirus; D004334:Drug Administration Schedule; D005260:Female; D007262:Infusions, Intravenous; D015552:Injections, Intralesional; D007783:Lactones / Q000008:administration & dosage* / Q000494:pharmacology*; D018942:Macrolides; D010212:Papilloma / Q000188:drug therapy* / Q000821:virology; D011817:Rabbits
D000970:Antineoplastic Agents; D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1