title: [Acute dimethylformamide (DMF) poisoning: a case report].
abstract: This paper describes a case of acute occupational intoxication by dimethylformamide in a worker assigned to polyurethanic resin preparation in a simulated leather factory. The peculiarity of this case is constituted by the association of a dimethylformamide classic clinical syndrome, frequently described in the scientific literature (alcohol intolerance, gastroenteric manifestations with liver injury), with coagulation alterations and thrombocytopenia. Measurement of environmental concentrations of the solvents and biological monitoring revealed high levels of exposure to dimethylformamide at the workplace. Our observations confirm the effects of dimethylformamide on hemostasis reported by other authors in previous studies. It is possible to speculate that the effects of dimethylformamide on coagulation and platelets strictly depend on the amount of solvent accumulated in the body.
authors.affiliation: Unità Operativa Igiene e Salute nei Luoghi di Lavoro, Azienda USL 4 di Prato.
authors.forename: F
authors.initials: F
authors.lastname: Amatimaggio
authors.forename: S
authors.initials: S
authors.lastname: Calistri
authors.forename: F
authors.initials: F
authors.lastname: Ventura
authors.forename: M
authors.initials: M
authors.lastname: Margheri
authors.forename: F
authors.initials: F
authors.lastname: Niglio
authors.forename: A
authors.initials: A
authors.lastname: Perico
authors.forename: S
authors.initials: S
authors.lastname: Perissi
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D004126:Dimethylformamide / Q000506:poisoning*; D017575:Gloves, Protective; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D011041:Poisoning / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D012997:Solvents / Q000506:poisoning*
chemical_list: D012997:Solvents; D004126:Dimethylformamide