Troglitazone, an euglycemic antidiabetic drug.
Troglitazone (or 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl) methoxy]benzyl}thiazolidine-2,4-dione, C24H27NO5S) is the first euglycemic drug. The molecules are held together in the lattice by intermolecular hydrogen bonds between the hydroxy O atom of the chroman moiety, and the ketone O and ring N atom of the thiazolidine-2,4-dione moiety.
Vyas
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Dr Reddy's Research Foundation, India.
Sivalakshmidevi
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Prabhakar
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Reddy
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D002839:Chromans / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D013844:Thiazoles / Q000737:chemistry*; D045162:Thiazolidinediones; D000077288:Troglitazone
D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077288:Troglitazone