Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation of profens.
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
Olsovská
J
J
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Flieger
M
M
Bachechi
F
F
Messina
A
A
Sinibaldi
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification*; D002087:Butyrates / Q000737:chemistry* / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004873:Ergolines / Q000737:chemistry* / Q000302:isolation & purification*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002087:Butyrates; D004873:Ergolines; D011422:Propionates; C056474:flobufen