4-Phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice.
A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteoblastic cells. SCRC2941-18, 2-amino-4-(4-chlorophenyl)-5-methylthiazole, was found to be the most potent inhibitor in the derivatives. Furthermore, SCRC2941-18 significantly suppressed the bone weight loss in the ovariectomized mice, an osteoporosis model.
Yamaguchi
K
K
Sagami Chemical Research Center, Sagamihara, Kanagawa, Japan.
Yada
M
M
Tsuji
T
T
Hatanaka
Y
Y
Goda
K
K
Kobori
T
T
D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control*; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010052:Ovariectomy; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology; D000093242:Interleukin-6 Inhibitors
D015850:Interleukin-6; D010281:Parathyroid Hormone; D013844:Thiazoles; D000093242:Interleukin-6 Inhibitors; C119486:2-amino-4-(4-chlorophenyl)-5-methylthiazole