title: Subacute toxicity study of the combination of ginseng (Panax ginseng) and ashwagandha (Withania somnifera) in rats: a safety assessment.
abstract: Ginseng (Panax ginseng) and Ashwagandha (Withania somnifera) are widely used as geriatric tonics. Both individually have not shown any toxicity on long term administration. Study was planned to assess the safety of the combination by doing subacute toxicity study in rats with 90 days oral administration using three doses. Food consumption, body weight, haematological, biochemical and histopathological parameters were studied. There was significant increase in body weight, food consumption and liver weight, and improved hematopoiesis was observed. Brain, heart, lung, liver, spleen, kidneys, stomach, testis and ovaries were normal on gross examination and histopathologically. Subacute toxicity studies in rats did not reveal any toxicity.
authors.affiliation: Department of Pharmacology, Government Medical College, Aurangabad.
authors.forename: A A
authors.initials: AA
authors.lastname: Aphale
authors.forename: A D
authors.initials: AD
authors.lastname: Chhibba
authors.forename: N R
authors.initials: NR
authors.lastname: Kumbhakarna
authors.forename: M
authors.initials: M
authors.lastname: Mateenuddin
authors.forename: S H
authors.initials: SH
authors.lastname: Dahat
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D004338:Drug Combinations; D004435:Eating / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D005894:Panax; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats; D015430:Weight Gain / Q000187:drug effects; D032341:Withania
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D006454:Hemoglobins; D010936:Plant Extracts; C030693:Ashwagandha