Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
Three C46 (1-3) and three C30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.
Kim
J S
JS
Research Institute of Drug Development, College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Lim
Y J
YJ
Im
K S
KS
Jung
J H
JH
Shim
C J
CJ
Lee
C O
CO
Hong
J
J
Lee
H
H
D000114:Acetylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene