Sequence analysis of F, SH, and HN genes among mumps virus strains in Japan.
The fusion (F), small hydrophobic (SH), and hemagglutinin-neuraminidase (HN) regions of 15 mumps virus (MuV) strains were sequenced to demonstrate the genetic variability since 1976 in Japan. The MuV strains were classified into 2 major genotypes, A and B, and genotype A was subdivided into three subtypes (A1, A2, and A3). A1 and A2 strains were mainly isolated in 1977 and 1980. A3 strains were isolated in 1985 and 1989 and genotype B strains in 1993 and 1994. Genotypes A1, A2, and A3 were closely related indigenous lineages in Japan but genotype B was in the similar cluster in Europe and North America.
Kashiwagi
Y
Y
Department of Pediatrics, Tokyo Medical University, Japan.
Takami
T
T
Mori
T
T
Nakayama
T
T
D001483:Base Sequence; D004279:DNA, Viral; D015707:HN Protein / Q000235:genetics*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D009107:Mumps / Q000821:virology; D009109:Mumps virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D014760:Viral Fusion Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D004279:DNA, Viral; D015707:HN Protein; D014760:Viral Fusion Proteins; D014764:Viral Proteins; C067386:small hydrophobic protein, Mumps virus