title: Computational fluid dynamic and magnetic resonance analyses of flow distribution between the lungs after total cavopulmonary connection.
abstract: Total cavopulmonary connection is a surgical procedure adopted to treat complex congenital malformations of the right heart. It consists basically in a connection of both venae cavae directly to the right pulmonary artery. In this paper a three-dimensional model of this connection is presented, which is based on in vivo measurements performed by means of magnetic resonance. The model was developed by means of computational fluid dynamics techniques, namely the finite element method. The aim of this study was to verify the capability of such a model to predict the distribution of the blood flow into the pulmonary arteries, by comparison with in vivo velocity measurements. Different simulations were performed on a single clinical case to test the sensitivity of the model to different boundary conditions, in terms of inlet velocity profiles as well as outlet pressure levels. Results showed that the flow distribution between the lungs is slightly affected by the shape of inlet velocity profiles, whereas it is influenced by different pressure levels to a greater extent.
authors.affiliation: Dipartimento di Bioingegneria, Politecnico di Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Migliavacca
authors.forename: P J
authors.initials: PJ
authors.lastname: Kilner
authors.forename: G
authors.initials: G
authors.lastname: Pennati
authors.forename: G
authors.initials: G
authors.lastname: Dubini
authors.forename: R
authors.initials: R
authors.lastname: Pietrabissa
authors.forename: R
authors.initials: R
authors.lastname: Fumero
authors.forename: M R
authors.initials: MR
authors.lastname: de Leval
mesh_terms: D000293:Adolescent; D001783:Blood Flow Velocity; D018610:Heart Bypass, Right; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular; D011651:Pulmonary Artery / Q000473:pathology* / Q000503:physiopathology*; D011673:Pulsatile Flow