Clinical efficacy and pharmacokinetics of 1% ropivacaine and 0.75% bupivacaine in peribulbar anaesthesia for cataract surgery.
Peribulbar anaesthesia with 1% ropivacaine and 0.75% bupivacaine, both with hyaluronidase, was assessed in a prospective, randomised, double-blind study of 100 patients undergoing cataract surgery. Pharmacokinetic data were obtained from 22 subjects. Akinesia of the globe developed slightly more rapidly in the ropivacaine group, but this difference was only statistically significant at 2 min after injection of the local anaesthetic. Lid akinesia was significantly more complete in the ropivacaine group. There were no differences between the groups with respect to peri-operative analgesia or duration of akinesia. The dose-adjusted maximum concentration of ropivacaine was approximately twice that of bupivacaine with significantly higher values of the area under the concentration-time curves. No drug-related adverse effects were observed. We conclude that there are no clinically significant differences in the quality of the sensory and motor block between 1% ropivacaine and 0.75% bupivacaine when used for peribulbar anaesthesia.
Huha
T
T
Department of Anaesthesiology, Oulu University Hospital, Kajaanintie, Oulu, Finland.
Ala-Kokko
T I
TI
Salomäki
T
T
Alahuhta
S
S
D000368:Aged; D000369:Aged, 80 and over; D000577:Amides / Q000097:blood / Q000494:pharmacology*; D000772:Anesthesia, Local / Q000379:methods; D000779:Anesthetics, Local / Q000097:blood / Q000494:pharmacology*; D002045:Bupivacaine / Q000097:blood / Q000494:pharmacology*; D002387:Cataract Extraction; D004311:Double-Blind Method; D005133:Eye Movements / Q000187:drug effects; D005143:Eyelids / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009068:Movement / Q000187:drug effects; D011446:Prospective Studies; D000077212:Ropivacaine
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine; D002045:Bupivacaine