4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists.
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
Cocuzza
A J
AJ
DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
Hobbs
F W
FW
Arnold
C R
CR
Chidester
D R
DR
Yarem
J A
JA
Culp
S
S
Fitzgerald
L
L
Gilligan
P J
PJ
D002460:Cell Line; D006801:Humans; D011485:Protein Binding; D011743:Pyrimidines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D011994:Recombinant Proteins