["CAPCIL". Posologic adjustment of aminoglycoside treatments].
The objectives of the therapeutic drug monitoring are to assume the efficacy and inocuity of a medical treatment and the patient's observance. The administration of a drug to a patient is not always performed in the same conditions and therefore treatment has to be adapted. When necessary, this one is very often based on empiric or very approximative notions and, more seldom, on results of plasmatic concentrations of the drug. The CAPCIL program allows the possibility to objectivate the medical decision and adapt the posology on the basis of two kinetic parameters: the biological half-life and the distribution volume. Indeed, most of pharmacokinetics modifications (drug interactions, diseases, ...) are affecting the two parameters. With basic informations so as height and weight, posology, treatment objectives and peak/trough plasmatic concentrations of the drug, the program is proposing several posology adaptation schemes. The example of a once-a-day administration of amikacin is discussed.
Gougnard
T
T
Service de Toxicologie Clinique, Centre Hospitalier Universitaire de Liège.
Charlier
C
C
Plomteux
G
G
D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D001827:Body Height; D001835:Body Weight; D003661:Decision Support Techniques; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D015203:Reproducibility of Results; D012984:Software; D014018:Tissue Distribution
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents