title: Renin-angiotensin system component gene polymorphism in Japanese bronchial asthma patients.
abstract: The influence of renin-angiotensin system (RAS) component gene polymorphism in the pathogenesis of bronchial asthma was investigated in an association study involving 119 bronchial asthma patients and 208 control subjects. The selected RAS polymorphisms were angiotensinogen (Agt) T235/M235 and angiotensin I-converting enzyme (ACE) insertion/deletion (I/D). The control allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.63/0.37) in this study were similar to the previous reports in Japanese normal population. The allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.65/ 0.35) among the asthma patients were not significantly different from those among the control subjects. There was no association between severity of bronchial asthma and the selected RAS component gene polymorphism. From these data, we conclude that in the Japanese population, the RAS component gene polymorphism is not associated with increased risk for bronchial asthma.
authors.affiliation: Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakahama
authors.forename: K
authors.initials: K
authors.lastname: Obata
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: O
authors.initials: O
authors.lastname: Kitada
authors.forename: M
authors.initials: M
authors.lastname: Sugita
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: N
authors.initials: N
authors.lastname: Kawada
authors.forename: T
authors.initials: T
authors.lastname: Moriyama
mesh_terms: D000328:Adult; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A