Liver regeneration after extended right hemihepatectomy in patients with hilar or diffuse bile duct carcinoma.
OBJECTIVE
The degree to which liver size can be restored and the factors that determine liver regeneration after major hepatectomy are not well understood.


METHODS
Liver volumes (LV) were estimated from computed tomography scans in 16 patients who survived with no evidence of cancer recurrence more than 1 year after extended right hemihepatectomy.


RESULTS
The mean percentage of LV at 1 year was 75.7 +/- 9.5% and LV did not change significantly beyond 1 year after surgery. A significant correlation was observed between LV at 1 year and body surface area (r = 0.79, p < 0.001). A significant inverse correlation was observed between LV at 1 year and the plasma retention rate of indocyanine green at 15 min (the ICG 15 value) (r = -0.72, p < 0.01).


CONCLUSIONS
In adults, the liver does not always regain its pre-operative size after hepatectomy. Patients' body size and intrinsic liver function or liver blood flow, represented by the ICG 15 value, may be related to regenerated liver size.
Miyagawa
S
S
First Department of Surgery, Shinshu University, School of Medicine, Matsumoto, Japan.
Kawasaki
S
S
Noike
T
T
Nomura
K
K
Kobayashi
A
A
Shimada
R
R
Imamura
H
H
D000368:Aged; D001650:Bile Duct Neoplasms / Q000601:surgery*; D017734:Bile Ducts, Extrahepatic; D001827:Body Height; D001830:Body Surface Area; D001835:Body Weight; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D016014:Linear Models; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period