Adenosine and neopterin levels in cerebrospinal fluid of patients with neurological disorders.
We determined the cerebrospinal fluid (CSF) levels of adenosine, a mediator of cerebral blood flow regulation, and neopterin, a macrophage-producing compound, in patients with neurological disorders. Compared to control subjects, the adenosine levels were significantly increased in the patients with acute-stage cerebral infarction (n=12, p<0.0001), acute meningitis (n=10, p<0.0001), or amyotrophic lateral sclerosis (ALS, n=12, p<0.05) (Mann-Whitney U-test). The neopterin levels were significantly increased in the 41 patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP, p<0.0001), acute meningitis (p<0.0001), ALS (p<0.05) (Mann-Whitney U-test), or acute-stage cerebral infarction (p<0.005, Student's t-test). In the analysis of 41 HAM/TSP patients, the neopterin levels were significantly correlated with the cell number and glucose levels in the CSF, and were a sensitive marker of inflammation. Several of the HAM/TSP patients with increased adenosine levels were probably complicated with other diseases. The increased neopterin levels in the HAM/TSP group persisted, suggesting that the mononuclear cellular infiltration remained for a long time.
Yoshida
Y
Y
School of Medical Sciences, Faculty of Medicine, Kagoshima University.
Une
F
F
Utatsu
Y
Y
Nomoto
M
M
Furukawa
Y
Y
Maruyama
Y
Y
Machigashira
N
N
Matsuzaki
T
T
Osame
M
M
D000241:Adenosine / Q000134:cerebrospinal fluid*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000134:cerebrospinal fluid*; D011379:Prognosis; D012720:Severity of Illness Index
D015415:Biomarkers; D019798:Neopterin; D005947:Glucose; D000241:Adenosine