Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat.
The histamine H1 receptor binding capacity of the amygdalas of amygdaloid kindled rats was studied. In the kindled nonstimulated amygdala, significant decreases in K(D) and B(max) values compared with those of control amygdala were found 1 week after the last kindled seizure. One month after the last kindled seizure, the decreased K(D) value was sustained in the kindled nonstimulated amygdala. This decreased Bmax value 1 week after the last kindled seizure in nonstimulated amygdala may partly and transiently contribute to kindled seizure susceptibility. The decreased K(D) value in nonstimulated amygdala observed until 1 month after the last kindled seizure indicates the long-lasting increment of binding affinity of the pyrilamine binding site of the histamine H1 receptor in the steady state of kindled seizure susceptibility.
Toyota
H
H
Department of Psychiatry, Tohoku University School of Medicine, Sendai, Japan.
Ito
C
C
Yanai
K
K
Sato
M
M
Watanabe
T
T
D000679:Amygdala / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D004198:Disease Susceptibility; D004292:Dominance, Cerebral / Q000502:physiology; D006634:Histamine H1 Antagonists / Q000378:metabolism; D007696:Kindling, Neurologic / Q000378:metabolism*; D008297:Male; D011738:Pyrilamine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism
D006634:Histamine H1 Antagonists; D011969:Receptors, Histamine H1; D011738:Pyrilamine