title: [The ways of designing new-generation medicinal and biochemical agents by using ligand-receptor interactions for active membrane transport].
abstract: A new approach to designing drugs having antiviral, anticancer, and, possibly, other biological activities is presented. These compounds were designed by choosing the molecular systems having a capacity for biospecific transport across the membranes to the target cells. The compounds containing both pharmacologically active ("pharmacophores") groups and structural fragments of the ligands ensuring recognition, binding to receptor sites, as well as transmembranous transport to the target cells. The molecules comprises the clusters capable to be the substrates of the enzymes eliminating "pharmacophores" near the target cell. A number of the synthesized compounds exhibited a noticeable biological (including antiviral) activity.
authors.forename: A M
authors.initials: AM
authors.lastname: Iurkevich
authors.forename: V I
authors.initials: VI
authors.lastname: Shvets
mesh_terms: D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008024:Ligands; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism
chemical_list: D008024:Ligands; D004364:Pharmaceutical Preparations; D011956:Receptors, Cell Surface; D011955:Receptors, Drug