title: [Granular cell tumor of the scrotum with high pseudoepitheliomatous hyperplasia].
abstract: OBJECTIVE
  To report a rare case of scrotal granular cell tumor.
  
  
  METHODS
  A 19-year-old man presented with a nodule on the scrotum, 2 cm in diameter. It had been present for months and was covered with ulcerated epidermis. The tumor was resected.
  
  
  RESULTS
  The histological study disclosed a neoplasm composed of polygonal cells with cytoplasmic granules and pseudoepitheliomatous hyperplasia of the overlying skin. Immunohistochemically, the cells showed a strong positivity for S100 protein and vimentin. The proliferation index (ki 67) was low in its cells, but high in the overlying hyperplasic epidermal cells.
  
  
  CONCLUSIONS
  To our knowledge, this is the second case of scrotal granular cell tumor reported. The case described herein has the unique feature of severe overlying pseudoepitheliomatous hyperplasia. S100 positivity supports a neurogenic differentiation.
authors.affiliation: Servicio de Anatomía Patológica, Hospital de la Merced, Osuna, Sevilla, España.
authors.forename: M
authors.initials: M
authors.lastname: Medina Pérez
authors.forename: I
authors.initials: I
authors.lastname: Valpuesta Fernández
authors.forename: J
authors.initials: J
authors.lastname: Valero Puerta
authors.forename: D
authors.initials: D
authors.lastname: Pérez Martín
mesh_terms: D000328:Adult; D005834:Genital Neoplasms, Male / Q000473:pathology*; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D012611:Scrotum / Q000473:pathology*