title: Evaluation of semicarbazones for anticonvulsant and sedative-hypnotic properties.
abstract: A series of semicarbazones and thiosemicarbazones were synthesized and evaluated for anti-convulsant activity. Some compounds provided significant protection against Maximal Electroshock (MES) and subcutaneous strychnine induced seizures. Compound 1 was the most active in the series with activity in a dose of 30 mg/kg in the strychnine seizure pattern test and an ED50 of 10 mg/kg in the MES test. Hence it could serve as a prototype molecule for future development. Also compounds with a p-nitrophenyl substitution in place of the amino hydrogen of semicarbazone moiety showed activity in a dose of 30 mg/kg and an ED50 of 83 mg/kg in the MES test.
authors.affiliation: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: N
authors.initials: N
authors.lastname: Aggarwal
authors.forename: J S
authors.initials: JS
authors.lastname: Jain
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003292:Convulsants / Q000633:toxicity; D004597:Electroshock; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D004856:Postural Balance / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012664:Semicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013331:Strychnine / Q000037:antagonists & inhibitors / Q000633:toxicity; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D006993:Hypnotics and Sedatives; D012664:Semicarbazones; D013331:Strychnine