[Seven cases of marked pulmonary fibrosis in the upper lobe].
We report on 7 patients with marked idiopathic pulmonary fibrosis in the upper lung lobes. The patients were generally characterized by the following pathological and clinical features: (1) marked subpleural pulmonary opacities and reticular shadows mainly in the upper lobes, with a progressive reduction in lung volume; (2) nonspecific fibrosis (subpleural, zonal, rather well-defined fibrosis with small cysts and honeycomb lesions) in 5 patients and interstitial pneumonia in 2, mainly in the upper lobes; and (3) a slender build, and a family history of recurrent spontaneous pneumothorax. Clinically, all 7 cases resembled idiopathic upper-lobe fibrosis as described by Amitani in 1992. Further clinical and experimental research will be required to delineate the characteristics of idiopathic fibrosis affecting primarily the upper lobes.
Shiota
S
S
Department of Respiratory Medicine, Shouwa General Hospital, Tokyo, Japan.
Shimizu
K
K
Suzuki
M
M
Nakaya
Y
Y
Sakamoto
K
K
Iwase
A
A
Aoki
S
S
Matsuoka
R
R
Shimizu
S
S
Nagayama
Y
Y
Kawabata
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003550:Cystic Fibrosis / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000150:complications; D011658:Pulmonary Fibrosis / Q000473:pathology*