title: Operative treatment of tentorial herniation in herpes encephalitis.
abstract: Herpes simplex virus is the most common cause of acute viral encephalitis in children. Due to the variety of possible clinical manifestations the diagnosis is often overlooked in the early stages of the disease. Anti-viral therapy with acyclovir should be started whenever HSE is suspected. When there is further deterioration under virostatic therapy, a brain biopsy should be performed to verify the diagnosis. But even when the adequate medical therapy is established, massive brain edema and brain shift resulting in tentorial herniation can develop. Up to now the reported mortality of these patients is still around 30%. Here we report on a child with severe necrotizing herpes simplex encephalitis who developed severe tentorial herniation due to a right-sided mass lesion. The patient's status markedly improved after decompressive anterior temporal lobe resection. To our knowledge a similar case has not yet been reported in the literature. We suggest that anterior temporal lobe resection and decompressive craniotomy is of benefit in selected cases with tentorial herniation because both decompression and reduction of infectious material can be achieved.
authors.affiliation: Department of Neurosurgery, University of Cologne, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Ebel
authors.forename: J
authors.initials: J
authors.lastname: Kuchta
authors.forename: A
authors.initials: A
authors.lastname: Balogh
authors.forename: N
authors.initials: N
authors.lastname: Klug
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination; D012640:Seizures / Q000209:etiology; D018139:Simplexvirus / Q000302:isolation & purification*; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir