title: Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong.
abstract: The MICs of 17 antimicrobial agents for 181 Streptococcus pneumoniae strains were determined by the E-test. Overall, 69.1% were penicillin resistant (MIC > 0.06 microgram/ml). Resistance to ciprofloxacin (MIC > 2 microgram/ml), levofloxacin (MIC > 2 microgram/ml), or trovafloxacin (MIC > 1 microgram/ml) was found in 12.1, 5.5, or 2.2% of the strains, respectively. These high rates of resistance raise concerns for the future.
authors.affiliation: Department of Microbiology, Division of Infectious Diseases, University of Hong Kong, Hong Kong. plho@hkucc.hku.hk
authors.forename: P L
authors.initials: PL
authors.lastname: Ho
authors.forename: T L
authors.initials: TL
authors.lastname: Que
authors.forename: D N
authors.initials: DN
authors.lastname: Tsang
authors.forename: T K
authors.initials: TK
authors.lastname: Ng
authors.forename: K H
authors.initials: KH
authors.lastname: Chow
authors.forename: W H
authors.initials: WH
authors.lastname: Seto
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D018432:Drug Resistance, Multiple; D024841:Fluoroquinolones; D006723:Hong Kong; D006801:Humans; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones