Regulation of CA 125 expression in cultured human carcinoma cells.
CA 125 shedding is not a constitutive and stable process but may be affected by cell cycle and cell proliferation as well as by various growth factors and cytokines. Interferons, interleukin-1 beta, tumor necrosis factor-alpha and transforming growth factor-alpha have been shown to induce while glucocorticoids and transforming growth factor-beta have been shown to suppress the release of the tumor marker CA 125 from ovarian carcinoma cells. Several endogenous as well as exogenous factors may affect CA 125 biosynthesis; however, a major question remains whether this observed modulation of CA 125 expression in vitro is of clinical importance.
Marth
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C
Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria.
Zeimet
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AG
Widschwendter
M
M
Daxenbichler
G
G
D018394:CA-125 Antigen / Q000096:biosynthesis / Q000235:genetics*; D002453:Cell Cycle; D002455:Cell Division; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D018394:CA-125 Antigen; D016207:Cytokines; D006133:Growth Substances