A randomized, double-blind, placebo-controlled study of methylphenidate in patients with organic amnesia.
We examined the usefulness of methylphenidate (MPH) in the treatment of organic amnesia in a randomized, double-blind, placebo-controlled design. Twenty patients with amnesia due to closed head injuries (n = 10), viral encephalitis (n = 2), stroke lesions (n = 4), or surgical brain resections (n = 4) were assessed with a neuropsychological battery after the intake of MPH (10, 20, 30 or 40 mg), or placebo. We found no significant benefit of MPH for any of the cognitive tests.Copyright Lippincott-Raven Publishers
Tiberti
C
Department of Neuropsychiatry, RaGl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Sabe
L
Jason
L
Leiguarda
R
Starkstein
S