title: Dehydrogenase activity of infected cells and biological properties of HIV-1 variants.
abstract: Changes in dehydrogenase activity of some continuous cell lines were studied during the response to acute infection in vitro with HIV-1 variants having different biological features. Soon after infection, the dehydrogenase activity of infected cells increased, and this increase was greater and more prolonged with the HIV-1 r/h variant than with the HIV-1 s/l variant. Later stages showed decreased dehydrogenase activity of HIV-1-infected cells compared to the noninfected control; this is a manifestation of the cytodestructive effect of the virus. The changes increased monotonously (but not in direct proportion) with an increase in the infecting dose.
authors.affiliation: Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow, 123098, Russia.
authors.forename: M Y
authors.initials: MY
authors.lastname: Shchelkanov
authors.forename: V F
authors.initials: VF
authors.lastname: Eremin
authors.forename: I B
authors.initials: IB
authors.lastname: Sakhuriya
authors.forename: V V
authors.initials: VV
authors.lastname: Burunova
authors.forename: T V
authors.initials: TV
authors.lastname: Pavlova
authors.forename: G V
authors.initials: GV
authors.lastname: Kornilaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Karamov
mesh_terms: D002460:Cell Line; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000097:blood / Q000201:enzymology; D054303:HIV Reverse Transcriptase / Q000378:metabolism; D015497:HIV-1 / Q000201:enzymology / Q000502:physiology*; D006801:Humans; D009000:Monocytes / Q000821:virology; D010088:Oxidoreductases / Q000097:blood*
chemical_list: D016655:HIV Core Protein p24; D010088:Oxidoreductases; D054303:HIV Reverse Transcriptase