Conservation of human gamma-X centromeric satellite DNA among primates with an autosomal localization in certain Old World monkeys.
Gamma-X satellite DNA is a 220-bp tandemly arranged repetitive DNA with specificity for the centromeric region of the human X chromosome. The conservation of this human X centromeric satellite DNA sequence in primate species was evaluated by comparative fluorescence in-situ hybridization to metaphase chromosome preparations of the great apes and three Old World monkeys. Homologous gamma-X DNA were detected at centromeric locations in all six primate species. For the great apes, gamma-X was exclusively localized to the centromeric regions of the X chromosomes. Among the Old World monkeys studied, only the golden monkey exhibited localization to the X chromosome. In the black-and-white colobus and the pig-tailed macaque, human gamma-X sequences were localized to the pericentromeric regions of autosomes 1 and 4, respectively.
Lee
C
C
Department of Pathology, Cambridge University, UK.
Stanyon
R
R
Lin
C C
CC
Ferguson-Smith
M A
MA
D000818:Animals; D002503:Centromere; D002520:Cercopithecidae / Q000235:genetics*; D003104:Colobus / Q000235:genetics; D017124:Conserved Sequence; D004276:DNA, Satellite; D019143:Evolution, Molecular; D005260:Female; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008254:Macaca nemestrina / Q000235:genetics; D008297:Male; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics; D014960:X Chromosome
D004276:DNA, Satellite