title: Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.
abstract: The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT. In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. snpande@banaras.ernet.in
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: P
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: D
authors.initials: D
authors.lastname: Sriram
authors.forename: E
authors.initials: E
authors.lastname: de Clercq
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D007510:Isatin / Q000138:chemical synthesis / Q000494:pharmacology*; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D008352:Mannich Bases; D007510:Isatin