title: Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors.
abstract: A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.
authors.affiliation: BioChem Therapeutic Inc., Laval, Québec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Bachand
authors.forename: J
authors.initials: J
authors.lastname: DiMaio
authors.forename: M A
authors.initials: MA
authors.lastname: Siddiqui
mesh_terms: D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000991:Antithrombins; D001643:Bridged Bicyclo Compounds; D007769:Lactams