Elimination and excretion of a single dose of the mycotoxin fumonisin B2 in a non-human primate.
The mycotoxin fumonisin B2 (FB2), which can be present at significant levels in maize infected with the fungus Fusarium moniliforme, was dosed both iv and by gavage to vervet monkeys. It was rapidly eliminated from the plasma of vervet monkeys dosed i.v. with 2 mg FB2/kg body mass. The concentration of FB2 in plasma after the iv dose was characterized by an initial distributional phase and a subsequent elimination phase with a mean half-life of 18 min. When two monkeys were dosed by gavage with a single bolus (7.5 mg/kg body mass), only one showed detectable trace levels of FB2 in plasma (25-40 ng/ml over the 3-5 hr period after dosing). This indicates that, like FB1, FB2 has a limited bioavailability. Urinary excretion of FB2 was extremely low, even after i.v. dosing. In total, a mean of 4.1% of the i.v. dose and 0.2% of the gavage dose was recovered in urine over a 7-day period. The predominant route of excretion was via the faeces, mainly as the unmetabolized toxin or as a partially hydrolysed analogue, with the latter accounting for between 6% and 47% of the dose. Limited amounts (maximum of 1.1%) of the fully hydrolysed aminopolyol backbone of FB2 were recovered in faeces.
Shephard
G S
GS
Programme on Mycotoxins and Experimental Carcinogenesis, Medical Research Council, Tygerberg, South Africa.
Snijman
P W
PW
D000818:Animals; D001682:Biological Availability; D002264:Carboxylic Acids / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics* / Q000633:toxicity; D002522:Chlorocebus aethiops / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D037341:Fumonisins; D006207:Half-Life; D008297:Male; D009183:Mycotoxins / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine
D002264:Carboxylic Acids; D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; C056934:fumonisin B2