The change of different forms of AChE during the ontogenetic development of the central nervous system.
The change of AChE bands during postnatal ontogenetic development was analyzed with help of polyacrylamid gel electrophoresis in homogenized rat cerebellum and spinal cord by our verticular surface technique. With this technique and by varying the concentration, 7 bands (3 doubles and one single) were differentatied. The gained experimental results show that at the beginning of development mainly G1 form representing the single band, i.e. the monomeric form is present. The G4 form i.e. the tetrameric form representing the third band, evolves during development. The G1 monomeric form as a subunit traceably begins to build the tetrameric form during the course of 14 days by association, and nearly finishes building it in 21 days.
Lehotai
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Alzheimer's Disease-Research Laboratory, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000110:Acetylcholinesterase / Q000235:genetics* / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002531:Cerebellum / Q000201:enzymology* / Q000254:growth & development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D051381:Rats; D013116:Spinal Cord / Q000201:enzymology* / Q000254:growth & development
D007527:Isoenzymes; D046911:Macromolecular Substances; D000110:Acetylcholinesterase