title: Verbal fluency task affects gait in Parkinson's disease with motor freezing.
abstract: We examined the effects of a simultaneous verbal fluency task on walking in Parkinson's disease (PD) patients with freezing of gait (PD-F) compared to nonfreezing patients (PD-NF) or control subjects (C). Effects of antiparkinsonian medications on gait in PD-F were examined. PD-F patients exhibited a greater increase in the number of steps to complete the walk with verbal fluency, even when the effect of medication was taken into account (mean increase +/- SD): PD-F = 4.2 +/- 4.6, n = 10; PD-NF = 0.1 +/- 1.6, n = 9; C = 1.5 +/- 1.5, n = 19; P = .007. Medications improved walking in PD-F patients by decreasing the number of steps, the time to walk, and freezing. PD-F patients may be more dependent on attention for walking.
authors.affiliation: Department of Neurology, Oregon Health Sciences University, Portland VA Medical Center, 97201, USA.
authors.forename: R
authors.initials: R
authors.lastname: Camicioli
authors.forename: B S
authors.initials: BS
authors.lastname: Oken
authors.forename: G
authors.initials: G
authors.lastname: Sexton
authors.forename: J A
authors.initials: JA
authors.lastname: Kaye
authors.forename: J G
authors.initials: JG
authors.lastname: Nutt
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000978:Antiparkinson Agents / Q000494:pharmacology; D001288:Attention / Q000502:physiology*; D005260:Female; D005684:Gait / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D014936:Word Association Tests
chemical_list: D000978:Antiparkinson Agents