[Glucocorticoid deficiency of the adrenal cortex in chronic liver diseases].
OBJECTIVE
The study of blood levels of hydrocortisone and ACTH in patients with chronic hepatic lesions.


METHODS
Blood levels of hydrocortisone and ACTH were measured in 198 patients with chronic liver diseases (CLD) of different etiology and severity and in 39 healthy controls.


RESULTS
Blood hydrocortisone was subnormal while ACTH elevated in all the patients except those with chronic hepatitis running a favorable course. Changes in the hydrocortisone and ACTH content were the greatest in CLD of viral and autoimmune etiology, the least--of alcoholic etiology.


CONCLUSIONS
Hydrocortisone deficiency was most prominent in severe hepatic lesions.
Astaf'eva
O V
OV
Loginov
A S
AS
D000293:Adolescent; D000302:Adrenal Cortex / Q000378:metabolism*; D000309:Adrenal Insufficiency / Q000097:blood* / Q000209:etiology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000172:deficiency*; D008107:Liver Diseases / Q000097:blood* / Q000209:etiology; D008297:Male; D008875:Middle Aged
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone