A case of T-lineage lymphoblastic lymphoma/leukemia with t(4;11)(q21;p15) that switched to myelomonocytic leukemia at relapse.
A 51-year-old Japanese woman, initially diagnosed with T-lineage (CD2+, CD7+, CD3-, CD4-, CD8-) lymphoblastic lymphoma with t(4;11)(q21;p15), relapsed with acute myelomonocytic leukemia with the identical chromosomal abnormality. Southern-blot analysis revealed clonal rearrangements of an immunoglobulin heavy chain gene (JH) and T-cell receptor genes (J delta 1, J gamma 1, C beta 1) at first presentation, but germ line configurations of these genes at relapse. Leukemias with t(4;11)(q21;p15) may involve a hematopoietic progenitor capable of multilineage differentiation.
Kawakami
K
K
Division of Hematology, Tenri Hospital, Nara, Japan.
Miyanishi
S
S
Amakawa
R
R
Hayashi
T
T
Kurata
M
M
Nakamura
F
F
Tanaka
Y
Y
Ohno
Y
Y
Shiku
H
H
D017252:CD3 Complex; D015704:CD4 Antigens; D019070:Cell Lineage; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005803:Genes, Immunoglobulin; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D012008:Recurrence; D014178:Translocation, Genetic
D017252:CD3 Complex; D015704:CD4 Antigens