title: [Maternal serum cytokines concentrations during normal pregnancy and labor].
abstract: OBJECTIVE
  The purpose of our study was to determine maternal serum concentrations of IL-8, IL-6, IFN-gamma during normal pregnancy and labor.
  
  
  METHODS
  Maternal serum IL-8, IL-6 and IFN-gamma levels were measured by means of ELISA technique in 41 healthy pregnant women in 22-42 week gestation and 15 healthy women in labor at term. All newborns and afterbirths had no signs of infection.
  
  
  RESULTS
  IL-8 values for pregnant women ranged from 1.98 to 35.2 pg/ml with the median value 10.24 pg/ml, and the 95th percentile 24.5 pg/ml. IL-8 values for women in labor at term ranged from 3.96 to 54.8 pg/ml with the median 10.4 pg/ml. No statistically significant changes in serum IL-8 concentration were observed during pregnancy or in labor. Serum IL-6 concentrations in pregnant women ranged from 0 to 21.7 pg/ml with the median value 0 pg/ml, and the 95th percentile 15.5 pg/ml. Serum IL-6 concentrations in women in labor at term were significantly higher (p < 0.05): ranged from 0 to 39.2 pg/ml with the median 10.1 pg/ml and 95-th percentile 33.5 pg/ml. Maternal serum IFN-gamma concentrations in pregnant women ranged from 0 to 9.8 pg/ml with the median value 3.9 pg/ml, the 95th percentile 9.2 pg/ml and didn't differ during labor at term: range from 0 to 14.5 pg/ml, median 1.9 pg/ml.
  
  
  CONCLUSIONS
  Our data revealed that maternal serum IL-8 concentrations didn't changed during the course of pregnancy and in labor. Women in labor had significantly elevated serum IL-6 concentrations compared to those in pregnancy. We didn't observed such changes in serum IFN-gamma levels.
authors.affiliation: Instytutu Centrum Zdrowia Matki Polki.
authors.forename: M
authors.initials: M
authors.lastname: Nowak
authors.forename: P
authors.initials: P
authors.lastname: Oszukowski
authors.forename: M
authors.initials: M
authors.lastname: Szpakowski
authors.forename: E
authors.initials: E
authors.lastname: Małafiej
authors.forename: A
authors.initials: A
authors.lastname: Malinowski
authors.forename: A
authors.initials: A
authors.lastname: Wieczorek
authors.forename: E
authors.initials: E
authors.lastname: Wierzbicka
authors.forename: W
authors.initials: W
authors.lastname: Drzazga
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology*
chemical_list: D016207:Cytokines