title: Effect of gender on the pharmacokinetics of ofloxacin.
abstract: OBJECTIVE
  To assess the influence of gender on the pharmacokinetics of ofloxacin.
  
  
  METHODS
  Open-label study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Five healthy men and seven healthy women volunteers.
  
  
  METHODS
  Subjects received a single oral dose of ofloxacin 400 mg, and serial blood samples were collected for 24 hours. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography and pharmacokinetic parameters were determined. Statistical comparisons between genders were made with the Wilcoxon rank sum test.
  
  
  RESULTS
  Median volume of distribution at steady state/systemic bioavailability (V(ss)/F) was significantly smaller in women than in men, although when normalized for total body weight there were no differences. Except for terminal elimination half-life, which was 10% shorter in women, no other pharmacokinetic values were significantly different between genders. Median peak concentrations, although not statistically different, were 28% higher in women.
  
  
  CONCLUSIONS
  Ofloxacin V(ss)/F values were smaller in women than in men, explained by gender-related differences in weight.
authors.affiliation: Department of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, Indiana 46202, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Sowinski
authors.forename: S R
authors.initials: SR
authors.lastname: Abel
authors.forename: W R
authors.initials: WR
authors.lastname: Clark
authors.forename: B A
authors.initials: BA
authors.lastname: Mueller
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D001825:Body Fluid Compartments; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D012727:Sex Characteristics; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin