title: [The emergence of multiple antimicrobial resistance in Vibrio cholerae isolated from gastroenteritis patients in Ceará, Brazil].
abstract: Of 7058 Vibrio cholerae strains recovered from patients suspected of cholera in the State of Ceará between December 1991 and September 1993, two were resistant to antimicrobials (Ampicillin, erythromycin, trimethoprim-sulfamethoxazole, tetracycline) and to vibriostatic agent O/129 (2,4-diamino-6,7-diisopropylpteridine). From the bacteriological standpoint, one strain was identified as V. cholerae serogroup O:1, biotype El Tor, serovar Inaba, and another as V. cholerae serogroup O:22, biochemically classified as Heiberg type II. It was shown that only in the serogroup O:1 strain, multiple resistance was encoded by a plasmid transferrable by conjugation to Escherichia coli K12 and a sensitive strains of V. cholerae O1 and non-O1, with at a frequency between 8 x 10(-2) and 5 x 10(-6). The plasmid, with a molecular weight of 147 Kb, encoded both multiple resistance to antimicrobials and the vibriostatic compound (O/129), compatible with descriptions reported in other parts of world.
authors.affiliation: Laboratório de Zoonoses Bacterianas, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brasil.
authors.forename: E
authors.initials: E
authors.lastname: Hofer
authors.forename: B R
authors.initials: BR
authors.lastname: Quintaes
authors.forename: E M
authors.initials: EM
authors.lastname: dos Reis
authors.forename: D dos P
authors.initials: Ddos P
authors.lastname: Rodrigues
authors.forename: L M
authors.initials: LM
authors.lastname: Seki
authors.forename: I S
authors.initials: IS
authors.lastname: Feitosa
authors.forename: L H
authors.initials: LH
authors.lastname: Ribeiro
authors.forename: M R
authors.initials: MR
authors.lastname: Ferreira
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D001938:Brazil; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005759:Gastroenteritis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D012703:Serotyping; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents