title: Investigation of unsteady flow in a model of a ventricular assist device by numerical modelling and comparison with experiment.
abstract: Prior to this study, a clinical prototype of a sac-type ventricular assist device (VAD) was investigated experimentally, using both flow visualisation and Laser Doppler anemometry (LDA), in order to optimise its geometry. As poor optical access precluded the experimental investigation of the flow in some areas of the prototype VAD, computational fluid dynamics (CFD) was used in the present work. Flow patterns during one full pumping cycle were investigated in a simplified model of the VAD. The numerical solutions were compared with experimental results from an identical physical model. The model consists of the hemispherical cylinder and two attached tubes for the inflow and outflow. Instead of a diaphragm in the clinical device, which deforms non-uniformly during pumping, a piston with a matching hemispherical crown was used. A finite volume method was employed to solve the governing equations for the three-dimensional, unsteady, laminar flow of an incompressible, Newtonian fluid. The general flow features were predicted very well by the simulation, with some differences in the details of the flow structures. This allows the conclusion that CFD can be used to facilitate improvement of the design of the clinical device. The comparison of one-component velocity time histories at selected points showed that the predicted velocities were approximately 20-50% lower than those measured by LDA. Such underprediction would lead to erroneous results for particle residence times and may result in an underestimation of wall shear stresses.
authors.affiliation: Department of Manufacturing and Engineering Systems, Brunel University, Uxbridge, Middlesex, UK.
authors.forename: C S
authors.initials: CS
authors.lastname: König
authors.forename: C
authors.initials: C
authors.lastname: Clark
authors.forename: M R
authors.initials: MR
authors.lastname: Mokhtarzadeh-Dehghan
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006353:Heart-Assist Devices; D006439:Hemodynamics; D017078:Laser-Doppler Flowmetry; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D013314:Stress, Mechanical