title: Technique for construction of an in vivo model of simulated pulmonary metastases.
abstract: OBJECTIVE
  Existing methods used to simulate pulmonary metastases are unsatisfactory. The aim of this study was to create a simple in vivo model of pulmonary metastases by endobronchial deployment of small high-density beads in anesthetized dogs.
  
  
  METHODS
  Commercially available decorative beads measuring 2 and 4 mm in diameter and of high density (600 to 1200 Hounsfield units) were deployed in the peripheral airways of anesthetized dogs using catheter and guide wire manipulations through an endotracheal tube.
  
  
  RESULTS
  A total of 65 beads were placed in five dogs. Computed tomography demonstrated that 41 (63%) were satisfactorily located in the lung periphery, 9 (14%) were unsatisfactorily located in large airways, and 15 (23%) were not visible.
  
  
  CONCLUSIONS
  The endobronchial deployment of small high-density beads in the peripheral airways of anesthetized dogs is a novel and effective technique for creation of an in vivo model of pulmonary metastases.
authors.affiliation: Department of Radiology, Indiana University School of Medicine, Indianapolis, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Johnson
authors.forename: F V
authors.initials: FV
authors.lastname: Coakley
authors.forename: T J
authors.initials: TJ
authors.lastname: Carmody
authors.forename: R G
authors.initials: RG
authors.lastname: Dreesen
authors.forename: M D
authors.initials: MD
authors.lastname: Cohen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000556:secondary; D010865:Pilot Projects; D014057:Tomography, X-Ray Computed