title: Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice.
abstract: We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10,cis-12 isomer.
authors.affiliation: Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison 53706, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Park
authors.forename: J M
authors.initials: JM
authors.lastname: Storkson
authors.forename: K J
authors.initials: KJ
authors.lastname: Albright
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: M W
authors.initials: MW
authors.lastname: Pariza
mesh_terms: D016475:3T3 Cells / Q000187:drug effects / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007536:Isomerism; D008041:Linoleic Acids / Q000737:chemistry / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008041:Linoleic Acids; D014280:Triglycerides; D008071:Lipoprotein Lipase