title: Multicomponent evaluations of the oxidising actions and status of a peroxoborate-containing tooth-whitening system in whole human saliva using high resolution proton NMR spectroscopy.
abstract: High resolution 1H nuclear magnetic resonance (NMR) spectroscopy was employed to conduct a multicomponent investigation of the oxidation of salivary biomolecules by peroxoborate present in a tooth-whitening dentifrice formulation. The results acquired demonstrated that peroxoborate gave rise to the oxidative decarboxylation of the hydrogen peroxide scavenger pyruvate, a reaction generating acetate and CO2 as products. Experiments performed on chemical model systems confirmed the oxidative consumption of pyruvate by dentifrice-derived peroxoborate, and also revealed that the salivary electron donors cysteine and methionine (precursors to volatile sulphur compounds), were oxidised to cystine and methionine sulphoxide respectively. The biochemical and periodontal significance of these results is discussed.
authors.affiliation: Department of Conservative Dentistry, St Bartholomew's Hospital School of Medicine and Dentistry, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Lynch
authors.forename: A
authors.initials: A
authors.lastname: Sheerin
authors.forename: C J
authors.initials: CJ
authors.lastname: Silwood
authors.forename: M
authors.initials: M
authors.lastname: Grootveld
mesh_terms: D001881:Borates / Q000032:analysis* / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008956:Models, Chemical; D010084:Oxidation-Reduction; D011522:Protons; D012463:Saliva / Q000737:chemistry*; D014073:Tooth Bleaching
chemical_list: D001881:Borates; D011522:Protons; C014189:sodium peroxyborate