Pathogenicity of Mycobacterium fortuitum and Mycobacterium smegmatis to goldfish, Carassius auratus.
Despite the ubiquitous presence of atypical mycobacteria in the environment and the potential risk of infection in humans and animals, the pathogenesis of diseases caused by infection with atypical mycobacteria has been poorly characterized. In this study, goldfish, Carassius auratus were infected either with the rapidly growing fish pathogen, Mycobacterium fortuitum or with another rapidly growing mycobacteria, Mycobacterium smegmatis. Bacterial persistence and pathological host response to mycobacterial infection in the goldfish are described. Mycobacteria were recovered from a high percentage of inoculated fish that developed a characteristic chronic granulomatous response similar to that associated with natural mycobacterial infection. Both M. fortuitum and M. smegmatis were pathogenic to fish. Fish infected with M. smegmatis ATCC 19420 showed the highest level of giant cell recruitment compared to fish inoculated with M. smegmatis mc(2)155 and M. fortuitum. Of the three strains of mycobacteria examined, M. smegmatis ATCC 19420 was the most virulent strain to goldfish followed by M. fortuitum and M. smegmatis mc(2)155, respectively.
Talaat
A M
AM
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA.
Trucksis
M
M
Kane
A S
AS
Reimschuessel
R
R
D000818:Animals; D005393:Fish Diseases / Q000382:microbiology* / Q000473:pathology / Q000503:physiopathology; D006054:Goldfish; D006099:Granuloma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D009165:Mycobacterium Infections, Nontuberculous / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D019907:Mycobacterium fortuitum / Q000302:isolation & purification / Q000472:pathogenicity; D020102:Mycobacterium smegmatis / Q000302:isolation & purification / Q000472:pathogenicity; D010537:Peritoneum; D016019:Survival Analysis; D014774:Virulence