Biodegradable polylactic acid nanocapsules containing ciprofloxacin: preparation and characterization.
Nanocapsules have been studied as carriers to deliver different types of drugs into macrophages. Many studies have shown that the nanocapsules can enhance the biological response of the drugs. In this study, we prepared ciprofloxacin nanocapsules with polylactic acid. The ciprofloxacin is an antibacterial agent. The ciprofloxacin nanocapsules prepared have a means diameter of 168 nm. In phosphate buffer at pH 7.4, high encapsulation rate was obtained. The nanocapsules with high encapsulation rate can also be made from ciprofloxacin base.
Yu
W P
WP
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Wong
J P
JP
Chang
T M
TM
D001673:Biodegradation, Environmental; D002021:Buffers; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D002939:Ciprofloxacin / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004355:Drug Stability; D019344:Lactic Acid / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013997:Time Factors
D002021:Buffers; D002214:Capsules; D003692:Delayed-Action Preparations; D010713:Phosphatidylcholines; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002939:Ciprofloxacin