alpha 1-tubulin expression in proximally axotomized mouse cortical neurons.
This paper further characterizes the response to axotomy of mouse transcallosal cortical neurons, a population of neurons that seems to be particularly refractory to regeneration. Mouse transcallosal cortical neurons did not upregulate mRNA for the growth-associated protein alpha 1-tubulin following axotomy, even when the axonal distance from injury to cell body was only 100-300 microns. Previous experiments had found no upregulation of another growth-associated protein, GAP-43, by transcallosal neurons following axotomy 1-2 mm from the cell body. These latest results establish that this population of neurons fails to respond to axotomy even when it is extremely proximal and that this failure is not a peculiarity specific to one growth-associated protein but is indicative of a generally poor regenerative response.
Elliott
E J
EJ
Research Service, Veterans Administration Medical Center, Baltimore, Maryland, USA.
Parks
D A
DA
Fishman
P S
PS
D000818:Animals; D019771:Axotomy; D001930:Brain Injuries / Q000378:metabolism*; D002540:Cerebral Cortex / Q000293:injuries* / Q000378:metabolism; D003337:Corpus Callosum / Q000293:injuries* / Q000378:metabolism; D005456:Fluorescent Dyes; D017403:In Situ Hybridization; D051379:Mice; D008815:Mice, Inbred Strains; D009416:Nerve Regeneration / Q000502:physiology*; D009841:Oligonucleotides; D010761:Phosphorus Radioisotopes; D017966:Pyramidal Cells / Q000293:injuries* / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism*
D005456:Fluorescent Dyes; D009841:Oligonucleotides; D010761:Phosphorus Radioisotopes; D014404:Tubulin