The emergence of physiological genomics.
'Physiological genomics' represents a research paradigm shift emerging to define the functions of tens of thousands of newly discovered genes which are expected to emerge from the sequencing of the human genome and other model organisms. Genomic tools, which will allow a higher efficiency of identification of gene function, are being developed at remarkable speed. This article discusses some of the genomic and bioinformatic tools currently available or under development to provide the infrastructure for mapping and identification of gene function in simple organisms (bacteria, zebrafish, fly, worm) and complex mammalian organisms (mouse and rat). The problems facing the scientific community in the implementation of this functional approach are discussed as it is now evident that new technological and organizational infrastructures are emerging to link genes to overall function of whole organisms.
Cowley
A W
AW
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisc., USA. cowley@mcw.edu
D000818:Animals; D005796:Genes / Q000502:physiology*; D005821:Genetic Techniques; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D011315:Preventive Medicine / Q000379:methods; D013812:Therapeutics / Q000379:methods