title: Thrombotic thrombocytopenic purpura: brain CT and MRI findings in 12 patients.
abstract: Clinical-neuroimaging analysis of 12 thrombotic thrombocytopenic purpura (TTP) patients revealed a variety of brain lesions. These included reversible cerebral edema lesions with MRI features of reversible posterior leukoencephalopathy syndrome (RPLS). Most of the RPLS patients had hypertension and renal dysfunction, suggesting RPLS due to hypertensive encephalopathy. Prompt treatment usually led to neurologic recovery and disappearance of edematous lesions. Those with infarcts or hematomas had a poorer outcome. TTP should be added to the expanding spectrum of RPLS and hypertensive encephalopathy.
authors.affiliation: Department of Neurology, University at Buffalo (SUNY) School of Medicine and Biomedical Sciences, Dent Neurologic Institute and Millard Fillmore Hospital, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bakshi
authors.forename: Z A
authors.initials: ZA
authors.lastname: Shaikh
authors.forename: V E
authors.initials: VE
authors.lastname: Bates
authors.forename: P R
authors.initials: PR
authors.lastname: Kinkel
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011697:Purpura, Thrombotic Thrombocytopenic / Q000000981:diagnostic imaging* / Q000473:pathology*; D014057:Tomography, X-Ray Computed