Induction of food intake by a noradrenergic system using clonidine and fusaric acid in the neonatal chick.
To clarify noradrenergic systems on food intake of the neonatal chicks, we examined the effects of i.c.v injection of clonidine (CLON), an alpha2-receptor agonist, and fusaric (5-butylpicolinic) acid (FA), a dopamine (DA)-beta-hydroxylase (DBH) inhibitor. Although a high dose (250 ng) of CLON induced a narcoleptic response and reduced food intake, food intake at 30 min post-injection was enhanced by lower doses (25 and 50 ng) of CLON. Central administration of FA (25, 50 and 100 microg) increased food intake in a dose-dependent fashion. It is suggested that feeding behavior is stimulated by low levels of CLON and decreased by further production of norepinephrine (NE), and FA may play the disturbance of sleeping and then enhance food intake.
Bungo
T
T
Laboratory of Animal Feed Science, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Shimojo
M
M
Masuda
Y
Y
Choi
Y H
YH
Denbow
D M
DM
Furuse
M
M
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002645:Chickens; D003000:Clonidine / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology*; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005669:Fusaric Acid / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D015259:Dopamine Agents; D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid; D003000:Clonidine; D009638:Norepinephrine