title: Endocytosis: How dynamin sets vesicles PHree!
abstract: The dynamin GTPase is required for clathrin-dependent, receptor-mediated endocytosis. Exciting new studies have shown that dynamin's pleckstrin homology domain binds to phosphatidylinositol 4, 5-bisphosphate in vivo, thus localising dynamin directly at the plasma membrane and ultimately enabling vesiculation.
authors.affiliation: Structural Biology Programme, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Bottomley
authors.forename: P
authors.initials: P
authors.lastname: Lo Surdo
authors.forename: P C
authors.initials: PC
authors.lastname: Driscoll
mesh_terms: D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D003594:Cytoplasmic Granules; D019281:Dimerization; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism; D007425:Intracellular Membranes; D010750:Phosphoproteins
chemical_list: D001798:Blood Proteins; D010750:Phosphoproteins; C039077:platelet protein P47; D020558:GTP Phosphohydrolases; D034281:Dynamins