title: Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Company, Ltd., Machida, Tokyo 194-8533, Japan, and Pharmaceutical Research Institute, Kyowa Hakko Kogyo Company, Ltd., Nagaizumi, Shizuoka 411-8731, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanda
authors.forename: T
authors.initials: T
authors.lastname: Ashizawa
authors.forename: S
authors.initials: S
authors.lastname: Kakita
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kono
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: M
authors.initials: M
authors.lastname: Okabe
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007769:Lactams; D018942:Macrolides; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012510:Sarcoma 180; D013329:Structure-Activity Relationship; D013844:Thiazoles; D013871:Thiones; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; C118757:KF 22678; D007769:Lactams; D018942:Macrolides; D011714:Pyrans; D013844:Thiazoles; D013871:Thiones; C059000:leinamycin