title: Bone reactions to titanium screw implants in ovariectomized animals.
abstract: OBJECTIVE
  The purpose of this study was to investigate the reactions of bone tissue after the placement of implants into the tibiae of osteopenic model rats.
  
  
  METHODS
  Commercially pure titanium screw implants were placed in the bilateral proximal tibial metaphyses 168 days after ovariectomy had been performed on 12-week-old female Wistar rats. For control purposes, implants were similarly placed in sham-ovariectomy rats. The healing process was examined histologically by means of undecalcified sections at various intervals from 7 to 168 days after implantation. Through use of an automated imaging analytic system, changes in relative bone mass and implant-bone contact were histomorphometrically evaluated.
  
  
  RESULTS
  In the cortical bone area, only a slight difference in bone contact was noted with the implant until 28 days after implantation. However, ovariectomy significantly affected bone contact at 56 days after implantation. The rate of bone contact in the cancellous bone area and the relative bone mass around the implant were significantly lower in the test group than in the control group.
  
  
  CONCLUSIONS
  It is considered that a decrease in bone mass causes a reduction in the contact area between implant and bone and may also cause a reduction in the supporting ability of the implant because of thinning of the surrounding bone tissue.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Shirota
authors.forename: Y
authors.initials: Y
authors.lastname: Tokugawa
authors.forename: M
authors.initials: M
authors.lastname: Motohashi
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Michi
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D001835:Body Weight; D015519:Bone Density; D004967:Estrogens / Q000172:deficiency; D005260:Female; D006801:Humans; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia
chemical_list: D004967:Estrogens