title: Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes.
abstract: BACKGROUND
  While increased plasma concentrations of apolipoprotein B-containing lipoproteins are a feature of diabetic nephropathy associated with nephrotic range proteinuria, the relationship of plasma lipoproteins to increasing urine albumin concentration within the microalbuminuria range is less well-studied.
  
  
  METHODS
  We, therefore, examined the relationship between urine albumin excretion in the 0 to 100 mg/L range and plasma lipoproteins in 56 Oji-Cree with type 2 diabetes.
  
  
  RESULTS
  We found a significant direct relationship between the urinary albumin concentration within this low range and the plasma concentrations of total and low density lipoprotein cholesterol and apolipoprotein B (p = 0.015, 0.0032, and 0.0019, respectively).
  
  
  CONCLUSIONS
  These results suggest that the well-known relationship between gross proteinuria and hyperlipidemia may extend into the microalbuminuric range in subjects with type 2 diabetes.
authors.affiliation: Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, London, Ontario, Canada. robert.hegele@rri.on.ca
authors.forename: R A
authors.initials: RA
authors.lastname: Hegele
authors.forename: S B
authors.initials: SB
authors.lastname: Harris
authors.forename: B
authors.initials: B
authors.lastname: Zinman
authors.forename: A J
authors.initials: AJ
authors.lastname: Hanley
authors.forename: P W
authors.initials: PW
authors.lastname: Connelly
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000097:blood* / Q000150:complications; D001055:Apolipoproteins B / Q000097:blood*; D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007198:Indians, North American; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009864:Ontario; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D008074:Lipoproteins