Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives.
Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H37Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.
Ferrarini
P L
PL
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Pisa, Italy.
Manera
C
C
Mori
C
C
Badawneh
M
M
Saccomanni
G
G
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D009287:Naphthyridines