[The assessment of the effect of glucocorticosteroid and nonsteroidal anti-inflammatory preparations on the development of an erosive-ulcerative lesion of the gastrointestinal tract in patients with rheumatic diseases].
OBJECTIVE
A comparative evaluation of the frequency and severity of upper gastrointestinal mucosal lesions in patients taking nonsteroid anti-inflammatory drugs (NSAID) and glucocorticosteroids (GCS).


METHODS
The trial entered 1086 rheumatic patients examined endoscopically. To compare the effects of their medicines, the patients were divided into 3 groups: 726 patients on NSAID alone (group 1); 238 patients on NSAID and GCS (group 2); 122 patients on GCS only (group 3).


RESULTS
Gastropathies were diagnosed in 38.2, 32.4, 12.5% of group 1, 2 and 3 patients, respectively (the difference is significant). More serious diseases prevailed in group 1: multiple erosions and gastroduodenal ulcers. Group 2 and 3 patients had erosions only.


CONCLUSIONS
GCS are safer for gastrointestinal mucosa than NSAID. Combination of NSAID with GCS does not increase the risk of gastropathy onset compared to NSAID alone.
Karateev
A E
AE
Nasonova
V A
VA
Murav'ev
Iu V
IuV
D000328:Adult; D017677:Age Distribution; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D016145:Endoscopy, Digestive System; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000150:complications* / Q000188:drug therapy; D012307:Risk Factors; D017678:Sex Distribution; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids