title: Immunostimulation by plant polyphenols: a relationship between tumor necrosis factor-alpha production and tannin structure.
abstract: The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1beta and TNF-alpha from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin beta-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-alpha rather than IL-1beta is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an ealier proposal.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Feldman
authors.forename: K
authors.initials: K
authors.lastname: Sahasrabudhe
authors.forename: R S
authors.initials: RS
authors.lastname: Smith
authors.forename: W J
authors.initials: WJ
authors.lastname: Scheuchenzuber
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D005419:Flavonoids; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D013634:Tannins / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D000276:Adjuvants, Immunologic; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013634:Tannins; D014409:Tumor Necrosis Factor-alpha