Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
Only few cases of Behçet's and hematological malignancies have been reported until now. We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years. This case is reported and the occurrence of hematological malignancies and Behçet's disease is reviewed.
Bangerter
M
M
Department of Medicine III, University of Ulm, Germany.
Griesshammer
M
M
v Tirpitz
C
C
Krauter
J
J
Heil
G
G
Hafner
M
M
Kern
W
W
Heiss
M
M
Kern
P
P
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001854:Bone Marrow Cells; D002699:Chlorambucil / Q000008:administration & dosage; D002897:Chromosomes, Human, Pair 7; D016572:Cyclosporine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D009006:Monosomy / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D016572:Cyclosporine