Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?
Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B-cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.
Chan
J K
JK
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Miller
K D
KD
Munson
P
P
Isaacson
P G
PG
D019938:Cyclin D1 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D015203:Reproducibility of Results; D013194:Staining and Labeling
D019938:Cyclin D1