The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis.
In 13 subjects with ALS, we studied the safety and pharmacokinetic properties of Procysteine, a cysteine prodrug that increases levels of intracellular glutathione. We found that oral administration of Procysteine was safe. Procysteine enters CSF after both IV and oral dosing and accumulates to significant levels in CSF. We also observed that CSF levels of glutathione fall dramatically with aging.
Cudkowicz
M E
ME
Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown 02114, USA. Cudkowicz@helix.mgh.harvard.edu
Sexton
P M
PM
Ellis
T
T
Hayden
D L
DL
Gwilt
P R
PR
Whalen
J
J
Brown
R H
RH
D000284:Administration, Oral; D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D005978:Glutathione / Q000134:cerebrospinal fluid; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D011761:Pyrrolidonecarboxylic Acid; D013844:Thiazoles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D053778:Thiazolidines
D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid