title: Presence and potent immunosuppressive role of interleukin-10 in malignant pleural effusion due to lung cancer.
abstract: The presence and possible role of interleukin (IL)-10 were examined in malignant pleural effusion due to lung cancer. In 37 out of 55 cases examined, IL-10 was detectable in pleural effusion and the mean level with standard error was 62.1+/-12.1 pg/ ml. Spontaneous and lipopolysaccharide-induced production of anti-tumor cytokines such as IL-1beta and tumor necrosis factor (TNF)-alpha, by pleural macrophages, obtained from five patients with malignant pleurisy, were suppressed by IL-10. These findings suggest that IL-10 is present in the tumor-growing site and acts as a suppressive factor of local anti-tumor immunity in humans.
authors.affiliation: Third Department of Internal Medicine, The University of Tokushima School of Medicine, Japan. niseko@medclin.clin.med.tokushima-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Yanagawa
authors.forename: E
authors.initials: E
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmoto
authors.forename: H
authors.initials: H
authors.lastname: Bando
authors.forename: S
authors.initials: S
authors.lastname: Sone
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D016753:Interleukin-10 / Q000032:analysis / Q000276:immunology*; D008070:Lipopolysaccharides; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10