Neuropsychological, neuroradiological and clinical findings in multiple sclerosis. A 3 year follow-up study.
Cognitive impairment is a frequent feature in multiple sclerosis patients. To assess its evolution in comparison with clinical and neuroradiological evolution, we followed up 57 multiple sclerosis patients over a 3-year period. During this time EDSS deteriorated significantly but not the MRI lesional load nor the cognitive test performance; nevertheless both at the beginning and at the end of the follow-up neuropsychological results showed a significant correlation with both EDSS and lesional load. No clinical or paraclinical features could reliably predict neuropsychological evolution.Copyright Lippincott-Raven Publishers
Patti
F
Istituto di Scienze Neurologiche, Servizio di Neuroriabilitazione e Sclerosi Multipla, Policlinico dell'Universita di Catania, viale Andrea Doria 6, 95125 Catania, Catania, Italy.
Failla
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Ciancio
MR
L'Episcopo
MR
Reggio
A