Association of human papillomavirus infection and disease with magnitude of human immunodeficiency virus type 1 (HIV-1) RNA plasma level among women with HIV-1 infection.
Ninety-three women with human immunodeficiency virus type 1 (HIV-1) infection were enrolled in a cross-sectional study to evaluate the relationship between plasma HIV-1 RNA levels and coincident cervical infection and disease caused by human papillomaviruses (HPVs). HIV-1 RNA plasma levels of >10,000 copies/mL were highly associated with the presence in cervical specimens of HPV DNA of oncogenic (high risk) virus genotypes (P=.006; relative risk, 2.57). In addition, similar HIV-1 RNA plasma levels were associated with abnormal Pap smears (P=.01; relative risk, 2.11). In this study, 81% of women with high-risk HPV cervical infection had abnormal Pap smears. Measurement of HIV-1 RNA plasma levels may help to identify a subgroup of HIV-1-infected women at increased risk for cervical HPV infection and disease.
Luque
A E
AE
Strong Memorial Hospital, Rochester, NY 14642, USA. amneris_luque@urmc.rochester.edu luque@urmc.rochester.edu
Demeter
L M
LM
Reichman
R C
RC
D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D015497:HIV-1; D006801:Humans; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D010044:Outpatient Clinics, Hospital; D065006:Papanicolaou Test; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D012367:RNA, Viral / Q000097:blood*; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology*; D014626:Vaginal Smears
D012367:RNA, Viral