title: Level, sources and toxicity of polychlorinated biphenyls in the Italian diet.
abstract: We used the duplicate portion method to measure the daily dietary intake of total and congener-specific polychlorinated biphenyls (PCB) and to assess their potential toxicity in a group of 20 subjects consuming a typical Italian diet. The mean +/- SD intake of total PCB, measured by GC-MS, was 3.72 +/- 1.51 micrograms/person/day, comparable to values reported in similar studies world-wide, with individual intakes varying within one order of magnitude, from 0.97 to 10.59 micrograms/person/day. The di-ortho congeners 153, 18 and 138 were the PCB found in the highest concentrations (respectively 13.8%, 11.4% and 10.9% of the total) while the non-ortho coplanar congeners (77, 126 and 169) amounted to 0.5% of the total. The corresponding levels of toxicity (TCDD-like TEQ values ascribable to PCB) ranged from 4.6 up to 119 pg/person/day of TCDD-equivalents in 18 subjects, i.e. presumed no-risk levels, but with peaks of 2109 and 4553 pg/person/day in two subjects with significant intakes of the congener 126. Principal components analysis and redundancy analysis showed dairy products, meat and fish were the principal sources of PCB, and vegetables those with the highest toxicity index in the Italian diet.
authors.affiliation: Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Zuccato
authors.forename: S
authors.initials: S
authors.lastname: Calvarese
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: S
authors.initials: S
authors.lastname: Mangiapan
authors.forename: P
authors.initials: P
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Guzzi
authors.forename: R
authors.initials: R
authors.lastname: Fanelli
mesh_terms: D000328:Adult; D004032:Diet; D004785:Environmental Pollutants / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D005506:Food Contamination; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis* / Q000378:metabolism / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls