[The role of MHC class II genes in the etiopathogenesis of rheumatoid arthritis].
Rheumatoid arthritis (RA) is associated with HLA-DR4 and DR1 antigens. HLA-DRB1 gene sequences analysis demonstrated that only a limited set of alleles is positively associated with RA. Third hypervariable region sequences (70-74, 86) Q(R)R(K)RAA, G(V) are found in up to 95% of erosive RA. The presence of disease-associated allels may predict severe outcome of the disease. Therefore, their presence may allow us to start aggressive therapy in early stage of the disease.
Lacki
J K
JK
Kliniki Reumatologii, IChW Akademia Medyczna im. Karola Marcinkowskiego w Poznaniu.
Korczowska
I
I
Mackiewicz
S H
SH
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D015798:HLA-DR1 Antigen / Q000235:genetics; D015804:HLA-DR4 Antigen / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics
D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; D007135:Immunoglobulin Variable Region