title: Preoperative plasma levels of prothrombin fragment 1 + 2 correlate with the risk of venous thrombosis after elective hip replacement.
abstract: Better preoperative identification of those patients at high risk of developing a deep vein thrombosis (DVT) after hip surgery could reduce the incidence of this postoperative complication, which still occurs despite prophylaxis. One hundred fifty-nine patients undergoing elective total hip replacement and given anticoagulant prophylaxis, were investigated, looking for the presence of a hypercoagulable state, that represents one element of Virchow's triad predisposing to DVT. Plasma levels of three markers of coagulation activation, namely prothrombin fragment 1 + 2 (F1 + 2), thrombin-antithrombin III complexes (TAT) and D-dimer were measured using ELISA procedures and were correlated with the results of the postoperative phlebography. A high correlation (p < 0.001) between the preoperative plasma levels of F1 + 2 and the risk of postoperative venous thromboembolism was detected. The performance of TAT and D-dimer levels in predicting DVT was lower. These findings support the hypothesis that preoperative measurement of coagulation activation markers might be useful in predicting DVT following a total hip replacement.
authors.affiliation: 1st Orthopaedic Department, University of Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Corradi
authors.forename: F
authors.initials: F
authors.lastname: Lazzaro
authors.forename: E
authors.initials: E
authors.lastname: Cofrancesco
authors.forename: M
authors.initials: M
authors.lastname: Cortellaro
authors.forename: F
authors.initials: F
authors.lastname: Ravasi
authors.forename: F
authors.initials: F
authors.lastname: Bertocchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D017558:Elective Surgical Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011183:Postoperative Complications; D011516:Prothrombin / Q000032:analysis*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D011516:Prothrombin