[Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid].
We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996. Sensitivity and specificity of these two tests were high. This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.
Brandel
J P
JP
INSERM Unité 360, Hôpital de la Salpêtrière, Paris.
Beaudry
P
P
Delasnerie-Lauprêtre
N
N
Laplanche
J L
JL
D048948:14-3-3 Proteins; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology*; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000175:diagnosis; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011237:Predictive Value of Tests; D011506:Proteins / Q000032:analysis*; D012189:Retrospective Studies; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D002556:Cerebrospinal Fluid Proteins; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase; D010751:Phosphopyruvate Hydratase