title: An investigation of secondary exposure misclassification effects of lifelong occupational history in exposure estimation.
abstract: The effects of exposure misclassification on the interpretation of results of occupational epidemiological studies has been widely investigated and reported. Usually, only the direct effects of misclassification have been considered or simple estimates of misclassification rates have been assigned to various types of exposure estimation processes. Lifelong job profile data obtained from a previously published case-control study provided complete or nearly complete job histories of 511 decedents. An analysis of these work histories and the comparison of exposures related to longest-held job to estimated total lifetime exposures suggest that single job-based exposure estimates may lead to significant exposure misclassification rates. In addition, the appearance of shorter duration jobs in a study population occurring predominantly early in the work history may exacerbate problems associated with exposure misclassification. While few specific suggestions emerge from this analysis, the inclusion of extensive recording of the work history of study subjects emerges as a reasonable basis for the investigation and potential reduction of secondary misclassification of exposures in occupational epidemiological studies.
authors.affiliation: University of Oklahoma, Health Sciences Center-CHB, Oklahoma City 73190, USA.
authors.forename: N A
authors.initials: NA
authors.lastname: Esmen
authors.forename: T A
authors.initials: TA
authors.lastname: Hall
authors.forename: R A
authors.initials: RA
authors.lastname: Stone
authors.forename: G M
authors.initials: GM
authors.lastname: Marsh
authors.forename: M J
authors.initials: MJ
authors.lastname: Gula
authors.forename: C K
authors.initials: CK
authors.lastname: Gause
mesh_terms: D000368:Aged; D000395:Air Pollutants, Occupational / Q000032:analysis*; D001130:Arizona / Q000453:epidemiology; D015982:Bias; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D004784:Environmental Monitoring / Q000379:methods* / Q000592:standards; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D009026:Mortality; D016273:Occupational Exposure / Q000032:analysis* / Q000145:classification*; D009790:Occupations / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D000395:Air Pollutants, Occupational