Immunoadsorption for the treatment of bullous pemphigoid.
We treated 2 intractable patients with pemphigoid by absorbent plasmapheresis using dextran sulfate conjugated cellulose columns with an automated regenerating unit. During a 2 week period, this plasmapheresis was performed 4 to 6 times for Cases 1 and 2, respectively. Clinical findings including skin eruptions were remarkably improved, and the titers of antibasement membrane zone antibodies were decreased after the treatment of 1.8 to 4.2 L of plasma. These results suggest that the absorbent column is effective for intractable pemphigoid.
Ino
N
N
Department of Dermatology, Chiba University School of Medicine, Japan.
Kamata
N
N
Matsuura
C
C
Shinkai
H
H
Odaka
M
M
D000368:Aged; D001485:Basement Membrane / Q000276:immunology; D016264:Dextran Sulfate; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000628:therapy*; D010956:Plasmapheresis; D016896:Treatment Outcome
D016264:Dextran Sulfate