title: Distribution and antimicrobial activity of ciprofloxacin in human soft tissues.
abstract: Interstitial ciprofloxacin concentrations in soft tissues were measured by microdialysis following intravenous administration of 200 mg to each of eight healthy volunteers. Interstitial ciprofloxacin concentrations were significantly lower than corresponding total serum drug concentrations; the interstitium-to-serum concentration ratios ranged from 0.55 to 0.73. An in vitro simulation based on interstitial pharmacokinetics showed a substantially lower antimicrobial activity than did the simulation based on serum pharmacokinetics. Thus, ciprofloxacin concentrations at the site of effect may be subinhibitory although effective concentrations are attained in serum.
authors.affiliation: Department of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Brunner
authors.forename: U
authors.initials: U
authors.lastname: Hollenstein
authors.forename: S
authors.initials: S
authors.lastname: Delacher
authors.forename: D
authors.initials: D
authors.lastname: Jäger
authors.forename: R
authors.initials: R
authors.lastname: Schmid
authors.forename: E
authors.initials: E
authors.lastname: Lackner
authors.forename: A
authors.initials: A
authors.lastname: Georgopoulos
authors.forename: H G
authors.initials: HG
authors.lastname: Eichler
authors.forename: M
authors.initials: M
authors.lastname: Müller
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003238:Connective Tissue / Q000378:metabolism; D006801:Humans; D008297:Male; D017551:Microdialysis
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin