title: Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists.
abstract: The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.
authors.affiliation: DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cocuzza
authors.forename: D R
authors.initials: DR
authors.lastname: Chidester
authors.forename: S
authors.initials: S
authors.lastname: Culp
authors.forename: L
authors.initials: L
authors.lastname: Fitzgerald
authors.forename: P
authors.initials: P
authors.lastname: Gilligan
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D006571:Heterocyclic Compounds; D018019:Receptors, Corticotropin-Releasing Hormone