Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population.
Recently a relationship between serotonin transporter transcriptional control region (5-HTTLPR) polymorphism and anxiety related personality traits in Caucasians was reported. We performed PCR of DNAs from the blood for determining the 5-HTTLPR genotypes of 191 Japanese subjects, which were medical staff and students, and obtained Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI) in 144 subjects. The association was analyzed by one-way ANOVA. The present study demonstrated that allelic frequency of 5-HTTLPR (s allele frequency was 0.785) in our subjects was considerably different from that in Caucasians. No significant differences were found in the anxiety-related personality traits among genotypes, while cooperativeness in TCI showed a significant difference among genotypes. The property of 5-HTTLPR may not be reflected directory on the personality inventories.
Kumakiri
C
C
Department of Neuropsychiatry, Chiba University School of Medicine, Japan.
Kodama
K
K
Shimizu
E
E
Yamanouchi
N
N
Okada
S
S
Noda
S
S
Okamoto
H
H
Sato
T
T
Shirasawa
H
H
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000097:blood; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins / Q000235:genetics; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D050486:Serotonin Plasma Membrane Transport Proteins; D044465:White People / Q000235:genetics
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA