title: Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer.
abstract: Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, developed quadriplegia. Electroneurophysiological examination, as well as a muscle biopsy, showed a typical picture of acute quadriplegic myopathy with loss of thick filament proteins. This is, to the best of our knowledge, the first reported case of this complication following APSCT.
authors.affiliation: Department of Hematology, Huddinge University Hospital, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Samuelsson
authors.forename: H
authors.initials: H
authors.lastname: Zackrisson
authors.forename: L
authors.initials: L
authors.lastname: Tokics
authors.forename: P
authors.initials: P
authors.lastname: Ljungman
authors.forename: E
authors.initials: E
authors.lastname: Lidbrink
authors.forename: P
authors.initials: P
authors.lastname: Pircher
authors.forename: L
authors.initials: L
authors.lastname: Larsson
mesh_terms: D000208:Acute Disease; D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D011782:Quadriplegia / Q000209:etiology*; D014182:Transplantation, Autologous