Primary advanced gastric small cell carcinoma: a case report and review of the literature.
We report a 73-yr-old man with primary advanced gastric small cell carcinoma, pure type. A large, Borrman type I tumor was located from the cardia to the entire gastric fundus and upper body. Atypical cells showed a round nucleus, small nucleolus, dense to granular chromatin, and scant cytoplasm. The histological findings indicates an advanced stage and exposure to the gastric serosa. Mitotic figures were observed. There was a proliferation of a sheet-like, solid pattern, but no rosette-like, sqamoid, or glandular patterns. The neoplastic cells were positive for Leu-7 (CD57) and 123C3 (CD56, neural cell adhesion molecule, NCAM) on the surface membrane. We diagnosed this case as primary advanced gastric small cell carcinoma, pure type, and report that Leu-7 and 123C3 monoclonal antibodies are useful markers for gastric small cell carcinoma. The 32 previously reported cases of gastric small cell carcinoma are also reviewed.
Takaku
H
H
Department of Surgery, Mito Saiseikai General Hospital, Ibaraki, Japan.
Oka
K
K
Naoi
Y
Y
Santoh
N
N
Setsu
Y
Y
Mori
N
N
D000368:Aged; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*