title: [Severe lactic acidosis disease disclosing milk-protein intolerance to cows' milk].
abstract: The age of discovery and initial symptoms of cow milk allergy can vary. Lactic acidosis is exceptionally associated to this allergy.
  
  
  METHODS
  A 32-day-old girl was admitted for a severe malaise with metabolic acidosis and hyperlactacidemia. There were no neonatal or family problems; breastfeeding was stopped on the 25th day. Fever was noted on the 29th day and her mother reported behavior anomalies followed by a severe malaise with unconsciousness between the 29th and 32nd day. At admission, the infant showed a severe neurological distress, hypotonia and lethargy. Infection and neurological imaging were normal. A compensated metabolic acidosis with hyperlactacidemia (5.96 mmol/L) was noted. There was no argument for esophageal reflux nor vagal hypertony; mitochondrial cytopathy was also excluded. After a 24 hours fast, the clinical state gradually improved and normalized at h48. The infant was discharged with a milk protein hydrolysate formula. Her mother attempted to reintroduce cow milk on the 59th and 64th day, but this was immediately followed by allergic manifestations which supported the diagnosis of cow milk allergy.
  
  
  CONCLUSIONS
  Neurological distress and hyperlactacidemia exceptionally reveal this type of intolerance. The mechanism of hyperlactacidemia remains unclear; it is possibly the consequence of severe changes of the intestinal mucosa, an exclusive glycolytic tissue.
authors.affiliation: Service de pédiatrie, hôpital Louis-Mourier, Colombes, France.
authors.forename: C
authors.initials: C
authors.lastname: Rizk
authors.forename: L
authors.initials: L
authors.lastname: Valdes
authors.forename: H
authors.initials: H
authors.lastname: Ogier de Baulny
authors.forename: J M
authors.initials: JM
authors.lastname: Saudubray
authors.forename: C
authors.initials: C
authors.lastname: Olivier
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000209:etiology*; D000818:Animals; D005215:Fasting; D005260:Female; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000097:blood; D008892:Milk / Q000009:adverse effects; D016269:Milk Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D008894:Milk Proteins / Q000009:adverse effects*; D009123:Muscle Hypotonia / Q000209:etiology; D012894:Sleep Stages / Q000502:physiology
chemical_list: D008894:Milk Proteins; D019344:Lactic Acid