title: Pancreatic endocrine carcinoma with multiple hormone production in a raccoon (Procyon lotor).
abstract: A pancreatic endocrine carcinoma with lung metastases was found in a 15-year-old male raccoon. This tumour was characterized by great variation in cell size and production of multiple polypeptide hormones. Endocrine markers expressed by the neoplastic cells were, in descending order of frequency, chromogranin A, pancreatic polypeptide (PP), glucagon, somatostatin and insulin. Co-expression of PP and glucagon, somatostatin or insulin was demonstrated immunohistochemically with consecutive sections, and cells with both glucagon and insulin were also observed. The pattern of co-expression was similar to that in the earliest stages of murine pancreatic development. Amyloid deposits in the islets of Langerhans, which reacted with antibody to islet amyloid polypeptide, were thought to be associated with age.
authors.affiliation: Iida Livestock Hygiene Service Centre, 2-678 Ootemachi, Iida, Nagano, 395-0034, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Matsuura
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000662:veterinary*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D017809:Fatal Outcome; D005934:Glucagon / Q000032:analysis; D007328:Insulin / Q000032:analysis; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000662:veterinary*; D010191:Pancreatic Polypeptide / Q000032:analysis; D011821:Raccoons; D013004:Somatostatin / Q000032:analysis
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D007328:Insulin; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D005934:Glucagon