title: Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura.
abstract: Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.
authors.affiliation: Section of Hematology/Oncology, Department of Internal Medicine, University of Chicago, Illinois, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Zent
authors.forename: J
authors.initials: J
authors.lastname: Ratajczak
authors.forename: M Z
authors.initials: MZ
authors.lastname: Ratajczak
authors.forename: J
authors.initials: J
authors.lastname: Anastasi
authors.forename: P C
authors.initials: PC
authors.lastname: Hoffman
authors.forename: A M
authors.initials: AM
authors.lastname: Gewirtz
mesh_terms: D000328:Adult; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000473:pathology*; D013926:Thrombopoietin / Q000097:blood*
chemical_list: D013926:Thrombopoietin