A DLST genotype associated with reduced risk for Alzheimer's disease.
Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
Sheu
K F
KF
Burke Medical Research Institute, Cornell University Medical College, White Plains, NY 10605, USA.
Brown
A M
AM
Kristal
B S
BS
Kalaria
R N
RN
Lilius
L
L
Lannfelt
L
L
Blass
J P
JP
D000217:Acyltransferases / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000217:Acyltransferases; C021515:dihydrolipoamide succinyltransferase