Plasmapheresis for removal of myeloperoxidase antineutrophil cytoplasmic antibodies: a case report.
We report on a patient with myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated glomerulonephritis who had an elevated MPO-ANCA level and necrotizing crescentic glomerulonephritis on renal biopsy. She was treated by double filtration plasmapheresis and immunoadsorption plasmapheresis combined with steroid therapy and immunosuppressive agents. After plasmapheresis, the MPO-ANCA level decreased, and the cellular crescents were reduced. We conclude that plasmapheresis combined with steroid and immunosuppressive therapy may be useful to decrease the activity of MPO-ANCA associated crescentic glomerulonephritis.
Yorioka
N
N
Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima City, Japan.
Taniguchi
Y
Y
Amimoto
D
D
Katsutani
M
M
Kumagai
J
J
Yamakido
M
M
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology / Q000628:therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D010956:Plasmapheresis; D011239:Prednisolone / Q000627:therapeutic use
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D011239:Prednisolone