title: The "physiologically effective" correlates: peDk/L and peDk.
abstract: Introduced here are two predictive parameters, peDk/L and peDk. The prefix pe- (for physiologically effective) indicates that such values are estimates of lens transmissibility (Dk/L) and material permeability (Dk) and have been derived through a reverse application of the Residual Hypoxia model of Smith, relating corneal response (in hypoxic stress units) to lens transmissibility (Dk/L). Here, using independent databases, physiological responses to simple oxygen pathways (one layer, one material) but of unknown Dk value were entered into that model to estimate the Dk/L and (then by calculation) the Dk value of single vision rigid gas permeable (RGP) contact lenses. Also demonstrated was the application of this strategy for estimation of composite (integrated) Dk/L and Dk values of complex (multi-layer, multi-material) oxygen pathways, wherein one or more material Dk values and/or one or more local thickness are unknown.
authors.affiliation: The Ohio State University, College of Optometry, Columbus 43210-1240, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Hill
mesh_terms: D003261:Contact Lenses / Q000592:standards; D003315:Cornea / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010539:Permeability
chemical_list: D010100:Oxygen