Epidemiologic survey on organophosphate-induced delayed polyneuropathy (OPIDP) among patients recovered from Methamidophos poisoning.
As Methamidophos (MAF) is currently responsible for half of the pesticide intoxications and fatality cases in China, the need to assess the frequency and the characteristics of the OPIDP among the victims who recovered from MAF poisoning is obvious. One-hundred and four subjects suffering from MAF intoxication were selected according to their medical records in the local rural hospitals in the Mu-du suburb of Su-Zhou, and the Shi-Qiu suburb of Nanjing. Face-to-face interviews were performed during home visits to all selected subjects, with the only exception of 4 patients. In those cases, information was provided by their kin relatives. Fourteen cases of delayed polyneuropathy (OPIDP) were identified: all patients who suffered from OP poisoning and had OPIDP showed a typical clinical course. The overall incidence of OPIDP was surprisingly high: 13.5%. The risk of OPIDP was associated with the severity of the intoxication. No association was found between OPIDP incidence and sex, age or treatment with dexametholone during the acute phase of the disease (RR = 0.98, p = 0.79). All 14 cases of OPIDP recovered in one and a half year without any permanent disability.
Sun
D H
DH
Department of Occupational Health, Shanghai Medical University, China.
Zhou
H D
HD
Xue
S Z
SZ
D000208:Acute Disease; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology; D009946:Organothiophosphorus Compounds / Q000506:poisoning*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000453:epidemiology; D013406:Suicide, Attempted; D013997:Time Factors
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014655:methamidophos