title: [Methotrexate pneumonitis].
abstract: A 72 year old female with rheumatoid arthritis was treated with methotrexate for nine months. Four days before admission she complained of dyspnea NYHA III. Chest-X-ray revealed diffuse interstitial pneumopathy. Pulmonary infection was excluded by several microbiological samples. A pulmonary manifestation of rheumatoid arthritis is usually more chronic. Methotrexate-induced pneumonitis remained the most probable diagnosis. We halted methotrexate and initiated therapy with glucocorticoids. This treatment led to rapid clinical improvement and complete resolution of radiological changes.
authors.affiliation: Medizinische Klinik, Kantonsspital Aarau.
authors.forename: K
authors.initials: K
authors.lastname: Zingg
authors.forename: M
authors.initials: M
authors.lastname: Grossenbacher
authors.forename: D
authors.initials: D
authors.lastname: Conen
authors.forename: K
authors.initials: K
authors.lastname: Truninger
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D011859:Radiography
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate