title: Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors.
abstract: New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is a preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with synthetic compounds will be discussed in detail.
authors.affiliation: Department of Medicinal Chemistry, Cheil Jedang Corp., Kyonggi-Do, Korea. ckrhee@www.cheiljedang.com
authors.forename: C K
authors.initials: CK
authors.lastname: Rhee
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: B C
authors.initials: BC
authors.lastname: Suh
authors.forename: M X
authors.initials: MX
authors.lastname: Xiang
authors.forename: Y S
authors.initials: YS
authors.lastname: Youn
authors.forename: W Y
authors.initials: WY
authors.lastname: Bang
authors.forename: E
authors.initials: E
authors.lastname: Kim
authors.forename: J K
authors.initials: JK
authors.lastname: Shin
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006168:Guinea Pigs; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4