[Analysis of intermittent blood flow in experimental tumor using a transparent chamber].
Using a transparent chamber under a microscopic recording system equipped with a CCD camera, we measured real-time fluctuations of microvessel blood flow in an experimental murine tumor. Seven microvessels of the tumor showed 3-4 fluctuations in blood flow (intermittent blood flow) during the observation period (2 hours). Within the 120 min. monitoring period, we obtained approximately a maximum 52.5% of decreased blood flow. The duration of change in blood flow ranged from 15-45 min. Similar temporal fluctuations were seen in experimental animal tumors. Our data clearly demonstrated that fluctuations in blood flow (intermittent blood flow) in tumors are a common feature.
Nasu
R
R
Dept. of Radiology, Kansai Medical University.
Kimura
H
H
Akai
M
M
Uda
M
M
Akagi
K
K
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D015687:Cell Hypoxia; D005260:Female; D008833:Microcirculation / Q000502:physiology; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow / Q000502:physiology