Human immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.
T cells are central players in the immune response to infectious disease, with the specificity of their responses controlled by the T-cell receptor (TCR)/CD3 complex on the cell surface. Impairment of TCR/CD3-directed CD4(+) T-cell immune responses is frequently observed in individuals infected with human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). Virus replication is also regulated by T-cell activation factors, with HIV-1 and HIV-2 responding to different TCR/CD3-directed cellular pathways. We previously demonstrated that HIV-1 infection of the human interleukin-2-dependent CD4(+) T-cell line WE17/10 abrogates TCR/CD3 function and surface expression by a specific loss of CD3-gamma gene transcripts. In this study, we show that HIV-2 provokes the same molecular defect in CD3-gamma gene transcripts, resulting in a similar but delayed progressive loss of TCR/CD3 surface expression after infection.
Segura
I
I
International Institute of Cellular and Molecular Pathology, B1200 Brussels, Belgium.
Delmelle-Wibaut
C
C
Janssens
M
M
Cleuter
Y
Y
van den Broeke
A
A
Kettmann
R
R
Willard-Gallo
K E
KE
D015704:CD4 Antigens / Q000032:analysis; D002460:Cell Line; D015497:HIV-1 / Q000502:physiology*; D015498:HIV-2 / Q000502:physiology*; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis*; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000032:analysis / Q000235:genetics*
D015704:CD4 Antigens; D012333:RNA, Messenger; D017260:Receptor-CD3 Complex, Antigen, T-Cell