title: Time course of burn to repeated applications of capsaicin.
abstract: Human subjects rated the burn of 100 ppm capsaicin applied to the tongue via filter paper and replaced every minute. Capsaicin was presented at a constant concentration for 10 min, followed by 10 min of blank stimuli; this sequence was then repeated once. Both sensitization and desensitization were seen. A dynamic model composed of a level detector and change detector predicted the results and also previous data. Thus, the model provides a parsimonious description of responses to constant and intermittent capsaicin stimulation.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh, PA 15213, USA. cbalaban@vms.cis.pitt.edu
authors.forename: C D
authors.initials: CD
authors.lastname: Balaban
authors.forename: D H
authors.initials: DH
authors.lastname: McBurney
authors.forename: M
authors.initials: M
authors.lastname: Stoulis
mesh_terms: D000328:Adult; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D016018:Least-Squares Analysis; D008954:Models, Biological; D011601:Psychophysics; D013649:Taste / Q000187:drug effects*; D013997:Time Factors; D014059:Tongue / Q000294:innervation / Q000502:physiology
chemical_list: D002211:Capsaicin