Short-term effects of a new intravascular nitinol stent in canine arteries.
OBJECTIVE
To evaluate the short-term effects of a new nitinol stent on canine arteries.


METHODS
Eighteen nitinol mesh stents were placed in abdominal aortas, common iliac arteries, and renal arteries of six dogs. Angiography was performed to evaluate the patency rates and structural changes of arteries at 1 day, 3 weeks, 4 weeks, and 10 weeks after stent insertion. Gross and light microscopic examinations were performed after angiography.


RESULTS
On angiography, the patency rate was 100%, and no thrombosis was observed. All side branches from stented segments were patent. The mean neointimal thickness over and between stent wires was 94 and 167 microns. No difference was found between the aorta and the small vessels. Histologically, the neointima was covered with endothelium and was composed of subintimal fibrosis with mild inflammation.


CONCLUSIONS
The new type of nitinol mesh stent showed a high patency rate, with no thrombosis and relatively thin neointimal proliferation.
Lee
K W
KW
Department of Radiology, Seoul National University College of Medicine, Korea.
Park
J H
JH
Chung
J W
JW
Kim
W S
WS
Lee
W
W
Yeon
K M
KM
D000497:Alloys; D000792:Angiography; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery* / Q000648:ultrastructure; D001672:Biocompatible Materials; D004285:Dogs; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005355:Fibrosis / Q000000981:diagnostic imaging / Q000473:pathology; D005500:Follow-Up Studies; D015607:Stents; D017539:Tunica Intima / Q000648:ultrastructure
D000497:Alloys; D001672:Biocompatible Materials; C013616:nitinol