Danazol-induced biochemical changes in the rat ovary.
Effect of varying doses of danazol, a synthetic steroid derivative of 17 alpha-ethinyl testosterone has been observed on the biochemistry of the rat ovary. Biochemically total proteins decreased and total lipids increased with the danazol treatment. Triglycerides, the stored form of lipids formed the major components of lipids in the treated ovaries. The amount of phospholipids, glycolipids, cholesterol and free fatty acids decreased in the ovaries with increased danazol treatment. The functional significance of these changes have been discussed with ovarian physiology especially in relation to follicular growth and atresia.
Sangha
G K
GK
Department of Zoology, College of Basic Sciences & Humanities, Punjab Agricultural University, Ludhiana.
Chopra
N
N
D000818:Animals; D003613:Danazol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006017:Glycolipids / Q000378:metabolism; D007279:Injections, Subcutaneous; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D004965:Estrogen Antagonists; D005230:Fatty Acids, Nonesterified; D006017:Glycolipids; D010743:Phospholipids; D003613:Danazol