title: Dermatomyositis associated with invasive thymoma.
abstract: We report a case of dermatomyositis (DM) associated with invasive thymoma in a 22-year-old woman who was admitted to our hospital complaining of dyspnea which required ventilation support. The reddened elevated scaly eruptions were prominent over the extensor surfaces. Chest X-ray and computed tomography showed mediastinal masses, which were diagnosed as mixed type thymoma. Muscle and skin biopsy specimens were compatible with DM. She was treated with methylprednisolone pulse therapy followed by extended removal of the anterior mediastinal tumor and subsequent radiotherapy. She has had a good clinical course without recurrence of thymoma or DM for more than 3 years. The role of thymoma in the development of DM is discussed.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
authors.forename: T
authors.initials: T
authors.lastname: Ago
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Iwata
authors.forename: H
authors.initials: H
authors.lastname: Murai
authors.forename: K
authors.initials: K
authors.lastname: Okuma
authors.forename: T
authors.initials: T
authors.lastname: Tsuru
authors.forename: Y
authors.initials: Y
authors.lastname: Kaji
authors.forename: K
authors.initials: K
authors.lastname: Hayashida
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D003882:Dermatomyositis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D009361:Neoplasm Invasiveness; D012867:Skin / Q000473:pathology; D013945:Thymoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone