title: Helium and sulfur hexafluoride bolus washin in short-term microgravity.
abstract: We performed single-breath washout (SBW) tests in which He and sulfur hexafluoride (SF6) were inspired throughout the vital capacity inspirations or were inhaled as discrete boluses at different points in the inspiration. Tests were performed in normal gravity (1 G) and in up to 27 s of microgravity (microG) during parabolic flight. The phase III slope of the SBW could be accurately reconstructed from individual bolus tests when allowance for airways closure was made. Bolus tests showed that most of the SBW phase III slope results from events during inspiration at lung volumes below closing capacity and near total lung capacity, as does the SF6-He phase III slope difference. Similarly, the difference between 1 G and microG in phase III slopes for both gases was entirely accounted for by gravity-dependent events at high and low lung volumes. Phase IV height was always larger for SF6 than for He, suggesting at least some airway closure in close proximity to airways that remain open at residual volume. These results help explain previous studies in microG, which show large changes in gas mixing in vital capacity maneuvers but only small effects in tidal volume breaths.
authors.affiliation: Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070 Brussels, Belgium. bdutrieu@ulb.ac.be
authors.forename: B
authors.initials: B
authors.lastname: Dutrieue
authors.forename: A M
authors.initials: AM
authors.lastname: Lauzon
authors.forename: S
authors.initials: S
authors.lastname: Verbanck
authors.forename: A R
authors.initials: AR
authors.lastname: Elliott
authors.forename: J B
authors.initials: JB
authors.lastname: West
authors.forename: M
authors.initials: M
authors.lastname: Paiva
authors.forename: G K
authors.initials: GK
authors.lastname: Prisk
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D006371:Helium / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology; D013459:Sulfur Hexafluoride / Q000008:administration & dosage / Q000494:pharmacology*; D014109:Total Lung Capacity / Q000502:physiology; D014893:Weightlessness
chemical_list: D006371:Helium; D013459:Sulfur Hexafluoride