title: Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?
abstract: Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B-cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
authors.forename: J K
authors.initials: JK
authors.lastname: Chan
authors.forename: K D
authors.initials: KD
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Munson
authors.forename: P G
authors.initials: PG
authors.lastname: Isaacson
mesh_terms: D019938:Cyclin D1 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis*; D015203:Reproducibility of Results; D013194:Staining and Labeling
chemical_list: D019938:Cyclin D1