title: CNS drug discovery in the 21st century. From genomics to combinatorial chemistry and back.
abstract: The discovery of new drugs for psychiatric and neurological disorders has been greatly facilitated by advances in molecular biology, genetics and chemistry. Several examples are given of how these revolutionary advances have been applied to the discovery of new drugs that selectively modify serotonergic neurotransmission, including compounds which may prove to be more effective antidepressants.
authors.affiliation: Eli Lilly and Company, Indianapolis, IN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Paul
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001923:Brain Chemistry; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005544:Forecasting; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D011985:Receptors, Serotonin / Q000502:physiology; D013678:Technology, Pharmaceutical / Q000639:trends*
chemical_list: D000928:Antidepressive Agents; D011985:Receptors, Serotonin