Oligodendrocytes: from development to demyelinated lesion repair.
Spontaneous but incomplete remyelination is observed after a demyelinating lesion. We know since ten years now that oligodendrocyte progenitors, (OP) and totipotent neural stem cells remain present in the central nervous system of adult mammals. Moreover, these OP are more likely the cellular source of remyelinating cells. Here, we intend to demonstrate that the understanding of the myelination process that occurs during development might lead to new treatments aimed at inducing remyelination: stimulation of resident OP or grafting of purified perinatal OP.
Rogister
B
B
Department of Human Physiology, University of Liège, Belgium.
Belachew
S
S
Moonen
G
G
D002454:Cell Differentiation / Q000502:physiology; D003711:Demyelinating Diseases / Q000473:pathology / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D009416:Nerve Regeneration; D009836:Oligodendroglia / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D014284:Triiodothyronine / Q000502:physiology
D010982:Platelet-Derived Growth Factor; D014284:Triiodothyronine