title: Radiofrequency multielectrode catheter ablation in the atrium.
abstract: We developed a temperature-controlled radiofrequency (RF) system which can ablate by delivering energy to up to six 12.5 mm long coil electrodes simultaneously. Temperature feedback was obtained from temperature sensors placed at each end of coil electrodes, in diametrically opposite positions. The coil electrodes were connected in parallel, via a set of electronic switches, to a 150 W 500 kHz temperature-controlled RF generator. Temperatures measured at all user-selected coil electrodes were processed by a microcontroller which sent the maximum value to the temperature input of the generator. The generator adjusted the delivered power to regulate the temperature at its input within a 5 degrees C interval about a user-defined set point. The microcontroller also activated the corresponding electronic switches so that temperatures at all selected electrodes were controlled within a 5 degrees C interval with respect to each other. Physical aspects of tissue heating were first analysed using finite element models and current density measurements. Results from these analyses also constituted design input. The performance of this system was studied in vitro and in vivo. In vitro, at set temperatures of 70 degrees C, 85% of the lesions were contiguous. All lesions created at set temperatures of 80 and 90 degrees C were contiguous. The lesion length increased almost linearly with the number of electrodes. Power requirements to reach a set temperature were larger as more electrodes were driven by the generator. The system impedance decreased as more electrodes were connected in the ablation circuit and reached a low of 45.5 ohms with five coil electrodes in the circuit. In vivo, right atrial lesions were created in eight mongrel canines. The power needed to reach 70 degrees C set temperature varied between 15 and 114 W. The system impedance was 105+/-16 ohms, with one coil electrode in the circuit, and dropped to 75+/-12 ohms when two coil electrodes were simultaneously powered. The length and the width of the lesion set varied between 17.6+/-6.1 and 59.2+/-11.7 mm and 5.9+/-0.7 and 7.1+/-1.2 mm respectively. No sudden impedance rises occurred and 75% of the lesions were contiguous. From the set of contiguous lesions, 90% were potentially therapeutic as they were transmural and extended over the entire target region. The average total procedure and fluoroscopy times were 83.4 and 5.9 min respectively. We concluded that the system can safely perform long and contiguous lesions in canine right atria.
authors.affiliation: Boston Scientific, San Jose, CA 95134, USA.
authors.forename: D
authors.initials: D
authors.lastname: Panescu
authors.forename: S D
authors.initials: SD
authors.lastname: Fleischman
authors.forename: J G
authors.initials: JG
authors.lastname: Whayne
authors.forename: D K
authors.initials: DK
authors.lastname: Swanson
authors.forename: M S
authors.initials: MS
authors.lastname: Mirotznik
authors.forename: I
authors.initials: I
authors.lastname: McRury
authors.forename: D E
authors.initials: DE
authors.lastname: Haines
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation / Q000379:methods; D004285:Dogs; D004566:Electrodes; D006321:Heart / Q000000981:diagnostic imaging*; D009683:Nuclear Medicine / Q000295:instrumentation* / Q000379:methods*; D011859:Radiography; D013696:Temperature; D013997:Time Factors