title: [Endoscopic sphincterotomy in acute biliary pancreatitis. A multicenter study].
abstract: BACKGROUND
  Severe acute pancreatitis are still dangerous, as can be seen from the high mortality rate (around 30%). It's commonly known that in the last years diagnostic ability, precise stadiation and control over the disease development were increased. Surgical therapy is directed mainly to achieve the control over septic evolution, and in biliary pancreatitis to resolve hypertension and infection inside the biliary tree (now widely accepted as the real cause of this disease). Recently, some authors demonstrated that the prognosis of a pancreatitis can be greatly improved by stopping the evolution toward a severe phase with necrosis and multiple organ failure without any surgical operation. They believe that's possible to achieve this result performing an early endoscopic sphincterotomy in all biliary pancreatitis (recognised by means of echography and CT scan), before the development of necrosis.
  
  
  METHODS
  In our department, following this address, very good results have been obtained: that's why a multicentric trial has been carried out to appraise the results obtained by endoscopic sphincterotomy within 48 hours from the disease onset. Answers from 114 hospitals were received, with a total survey of more than 10,000 pancreatitis. Endoscopic sphincterotomy was performed in 55% of billiary pancreatitis, which were estimated at the onset, on second or third degree of Balthazar classification.
  
  
  RESULTS
  In 86% of patients, endoscopic sphincterotomy was performed within 48 hours from symptoms onset. Complications related to this treatment are reported in less than 4% of patients.
  
  
  CONCLUSIONS
  The procedure, avoiding the evolution toward necrosis and sepsis, allowed the reduction of surgical operations to 6.7%, and of the mortality amongst all cases gathered to 2.5%.
authors.affiliation: I Divisione Chirurgica, Ospedale S. Pertini, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Gargiulo
authors.forename: F
authors.initials: F
authors.lastname: Barbaro
authors.forename: G B
authors.initials: GB
authors.lastname: Valentini
authors.forename: G
authors.initials: G
authors.lastname: Caserta
authors.forename: A
authors.initials: A
authors.lastname: Gargiulo
authors.forename: F
authors.initials: F
authors.lastname: Manzi
authors.forename: A
authors.initials: A
authors.lastname: Mereu
authors.forename: G
authors.initials: G
authors.lastname: Occhigrossi
authors.forename: L
authors.initials: L
authors.lastname: Pinto
authors.forename: M
authors.initials: M
authors.lastname: Schiavone
mesh_terms: D000208:Acute Disease; D003937:Diagnosis, Differential; D006801:Humans; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D016717:Sphincterotomy, Endoscopic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome