title: FK506-induced leukoencephalopathy in children with organ transplants.
abstract: FK506-induced leukoencephalopathy is a well-known entity in adult organ transplant patients. The neurotoxicity of FK506 immunosuppression is frequently reversible, with either reduction or cessation of the drug. This neurologic syndrome is not well documented in children. We report the clinical and radiologic features in four pediatric cases of FK506 leukoencephalopathy. In two of the four patients this syndrome was reversible.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, FL, USA.
authors.forename: H V
authors.initials: HV
authors.lastname: Torocsik
authors.forename: R G
authors.initials: RG
authors.lastname: Curless
authors.forename: J
authors.initials: J
authors.lastname: Post
authors.forename: A G
authors.initials: AG
authors.lastname: Tzakis
authors.forename: L
authors.initials: L
authors.lastname: Pearse
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016377:Organ Transplantation; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D016559:Tacrolimus