Persistence of Cajal-Retzius cells in the adult human cerebral cortex. An immunohistochemical study.
The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme activity. The three basic morphological profiles-horizontal, pyriform and multipolar-were observed. The morphologies of labelled cells resembled those of neurons observed in Golgi studies of the human cerebral cortex. The presence of calcium binding proteins and NADPH-diaphorase in these cells suggests a possible inhibitory role as GABAergic neurons. The persistence of Cajal-Retzius cells in the adult cerebral cortex supports the idea that they undergo developmental dilution rather than postnatal degeneration.
Martín
R
R
Department of Cell Biology, Faculty of Sciences, University of Málaga, Spain.
Gutiérrez
A
A
Peñafiel
A
A
Marín-Padilla
M
M
de la Calle
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002540:Cerebral Cortex / Q000166:cytology* / Q000201:enzymology; D006801:Humans; D009252:NADPH Dehydrogenase / Q000032:analysis
D009252:NADPH Dehydrogenase