Design and synthesis of glutathione analogues.
This review reports recent structural modifications (since 1989) performed on the glutathione molecular both in the oxidized and reduced form. Relevant chemical aspects, biochemical consequences and therapeutical implications are illustrated. Natural thiols related to glutathione are also considered.
Lucente
G
G
Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, Italy.
Luisi
G
G
Pinnen
F
F
D000818:Animals; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D010084:Oxidation-Reduction
D005978:Glutathione