title: A DLST genotype associated with reduced risk for Alzheimer's disease.
abstract: Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
authors.affiliation: Burke Medical Research Institute, Cornell University Medical College, White Plains, NY 10605, USA.
authors.forename: K F
authors.initials: KF
authors.lastname: Sheu
authors.forename: A M
authors.initials: AM
authors.lastname: Brown
authors.forename: B S
authors.initials: BS
authors.lastname: Kristal
authors.forename: R N
authors.initials: RN
authors.lastname: Kalaria
authors.forename: L
authors.initials: L
authors.lastname: Lilius
authors.forename: L
authors.initials: L
authors.lastname: Lannfelt
authors.forename: J P
authors.initials: JP
authors.lastname: Blass
mesh_terms: D000217:Acyltransferases / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000217:Acyltransferases; C021515:dihydrolipoamide succinyltransferase