Allele dose analysis in recombinant inbred strains: a tool for multiple phenotype analysis with implications for quantitative trait loci mapping.
A considerable investment in genetic mapping is necessary to confirm linkages of quantitative trait loci for complex traits such as ethanol sensitivity, a significant predictor of alcoholism. Before embarking on such intensive mapping efforts in large intercrosses, we suggest an approach based on genetic marker data in recombinant strains that yield a rationale for selecting a battery of related phenotypes for confirmation studies of quantitative trait loci action. Using this approach with selected strains of mice, we retrospectively consider the relationship between ethanol sensitivity and neurotensin levels in several mammalian brain regions.
Markel
P D
PD
Department of Psychology, Minot State University, North Dakota 58703, USA.
Erwin
V G
VG
D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D015999:Multivariate Analysis; D010597:Pharmacogenetics; D051381:Rats; D018028:Receptors, Neurotensin / Q000187:drug effects / Q000235:genetics; D011995:Recombination, Genetic
D005819:Genetic Markers; D018028:Receptors, Neurotensin; D000431:Ethanol