[Mechanism of action of 2-aryloxy-2-thio-1,3,2-oxazaphosphorinane pesticides].
The interaction of 2-aryloxy-2-thio-1,3,2-oxazaphosphorinanes exhibiting nematocide, insecticide/acaricide, and synergetic activities with monoamine oxidases and the interaction of the corresponding oxones, 2-aryloxy-2-oxo-1,3,2-oxazaphosphorinanes, with various cholinesterases, carboxyl esterases, and monoamine oxidases were studied. We showed that the thioderivatives inhibited monoamine oxidases, whereas oxones, which are, as a rule, weak cholinesterase inhibitors, strongly inhibited carboxyl esterases of the American cockroach and were transformed with monoamine oxidases into the strong cholinesterase inhibitors, acyclic phosphamidates. This allowed us to explain the low toxicity of the thioderivatives, the high toxicity of the oxoderivatives, and the great difference in toxicities of thio- and oxocompounds in the 1,3,2-oxazaphosphorinane series. The capacity of thioderivatives to inhibit monoamine oxidases and of oxoderivatives and their further activation products to inhibit carboxyl esterases, i.e., both enzymes responsible for pyrethroid detoxication in insects, explains the synergetic activity of the 1,3,2-oxazaphosphorinane series.
Shipov
A E
AE
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
Genkina
G K
GK
Makhaeva
G F
GF
Malygin
V V
VV
Volkova
R I
RI
Roslavtseva
S A
SA
Eremina
O Iu
OIu
Bakanova
E I
EI
Mastriukova
T A
TA
Kabachnik
M I
MI
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000633:toxicity*; D007306:Insecticides / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D009943:Organophosphorus Compounds; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D009943:Organophosphorus Compounds