Role of red blood cells in pharmacokinetics of chemotherapeutic agents.
After oral or parenteral administration of chemotherapeutic agents, these drugs are transported to the tissues by the blood in different fractions: plasma water, plasma proteins or cells. In this review, the role of the red blood cell in storage, transport and metabolism of different anti-cancer drugs is described.
Schrijvers
D
D
Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium. Dirk.Schrijvers@uza.uia.ac.be
Highley
M
M
De Bruyn
E
E
Van Oosterom
A T
AT
Vermorken
J B
JB
D000284:Administration, Oral; D018943:Anthracyclines / Q000097:blood; D000903:Antibiotics, Antineoplastic / Q000097:blood; D000970:Antineoplastic Agents / Q000097:blood* / Q000493:pharmacokinetics; D001215:Asparaginase / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D004317:Doxorubicin / Q000097:blood; D015251:Epirubicin / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005472:Fluorouracil / Q000097:blood; D006801:Humans; D007069:Ifosfamide / Q000097:blood; D007263:Infusions, Parenteral; D015122:Mercaptopurine / Q000097:blood; D008727:Methotrexate / Q000097:blood; D017239:Paclitaxel / Q000097:blood; D017671:Platinum Compounds / Q000493:pharmacokinetics
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D017671:Platinum Compounds; D015251:Epirubicin; D004317:Doxorubicin; D015122:Mercaptopurine; D001215:Asparaginase; D017239:Paclitaxel; D005472:Fluorouracil; D007069:Ifosfamide; D008727:Methotrexate