title: Clear cell variant of calcifying epithelial odontogenic tumor (CEOT) in the maxilla: report of a case with immunohistochemical and ultrastructural investigations.
abstract: A rare case of clear cell variant of calcifying epithelial odontogenic tumor is presented with immunohistochemical and ultrastructural investigations. A 14-year-old Japanese girl was admitted with a complaint of swelling in the right posterior maxilla. Radiological examination showed a well-circumscribed radiolucent lesion located close to the impacted third molar. After only a partial tumor excision, the tumor recurred 13 years later. It appeared radiologically as an irregular radiodensity, and a subtotal maxillectomy was performed. Histological examination showed sheets and/or strands composed almost entirely of clear vacuolated epithelial cells in a stroma containing intercellular amyloid-like material and calcification. Histochemical and ultrastructural analysis detected cytoplasmic glycogen granules in the clear cells, and positive immunoreactivities for cytokeratins 8, 13 and 19; filaggrin and anti-ameloblastoma antibodies suggested an odontogenic epithelial origin.
authors.affiliation: Department of Oral Pathology, Tohoku University School of Dentistry, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kumamoto
authors.forename: I
authors.initials: I
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Tateno
authors.forename: J
authors.initials: J
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Ooya
mesh_terms: D000293:Adolescent; D000682:Amyloid / Q000032:analysis; D000912:Antibodies, Neoplasm / Q000032:analysis; D002114:Calcinosis / Q000473:pathology; D004847:Epithelial Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D000091344:Filaggrin Proteins; D006003:Glycogen / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007382:Intermediate Filaments / Q000473:pathology; D007633:Keratins / Q000032:analysis; D008441:Maxillary Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009808:Odontogenic Tumors / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D000682:Amyloid; D000912:Antibodies, Neoplasm; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007633:Keratins; D006003:Glycogen