Role of glutamate receptor subtypes in the lamprey respiratory network.
The respiratory role of glutamate receptors was investigated in the isolated lamprey brain preparation by analyzing the changes in respiratory activity induced by bath application of specific antagonists of ionotropic and metabotropic glutamate receptors. The results show that these antagonists differentially affect the pattern of breathing and provide the first evidence that both ionotropic and metabotropic glutamate receptors are involved in neurotransmission within the lamprey respiratory network.
Bongianni
F
F
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, 17177, Stockholm, Sweden. bongian@server1.pharm.unifi.it
Deliagina
T G
TG
Grillner
S
S
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D007608:Kainic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007736:Kynurenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007798:Lampreys; D009474:Neurons / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D012119:Respiration
D015763:2-Amino-5-phosphonovalerate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D005998:Glycine; D007608:Kainic Acid; D007736:Kynurenic Acid; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D018094:Receptors, Metabotropic Glutamate; C084485:7-chlorothiokynurenic acid; C079694:alpha-methyl-4-carboxyphenylglycine; C020889:dihydrokainic acid