Pituitary involvement by Wegener's granulomatosis: a report of two cases.
We describe two cases of pituitary involvement by Wegener's granulomatosis. At initial presentation, or during subsequent disease "flares," a pattern of pituitary abnormality was suggested. During periods of remission, we found the pituitary returned to a nearly normal appearance. Loss of the normal posterior pituitary T1 hyper-intensity matched a clinical persistence of diabetes insipidus, suggesting there is permanent damage to this structure by the initial disease process.
Katzman
G L
GL
Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Langford
C A
CA
Sneller
M C
MC
Koby
M
M
Patronas
N J
NJ
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000473:pathology; D018450:Disease Progression; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D010900:Pituitary Diseases / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D010904:Pituitary Gland, Posterior / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate