A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
Some extracts from Inula viscosa were examined for acute antiinflammatory activity in vivo. Three flavonoids: rhamnocitrin (1), 7-O-methylaromadendrin (3), and 3-O-acetylpadmatin (4); a sesquiterpene lactone, inuviscolide (2); a sesquiterpene acid, ilicic acid (5); and a digalactosyl-diacylglycerol, inugalactolipid A (6), were isolated from the CH2Cl2 extract, identified by spectroscopic methods, and characterized as the topical antiinflammatory principles of this species. All these compounds proved to be effective against 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice, although lacking activity against arachidonic acid-induced edema. In addition, compounds 5 and, markedly, 6 showed notable effects on a multiple-dose murine chronic dermatitis model. This is the first attempt to establish a rationale concerning the documented use of the plant on various skin diseases.
Máñez
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Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. V. Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
Recio
M C
MC
Gil
I
I
Gómez
C
C
Giner
R M
RM
Waterman
P G
PG
Ríos
J L
JL
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D016718:Arachidonic Acid; D002351:Carrageenan; D002908:Chronic Disease; D003872:Dermatitis / Q000188:drug therapy; D004075:Diglycerides / Q000302:isolation & purification* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D038143:Inula; D009682:Magnetic Resonance Spectroscopy; D019083:Mediterranean Region; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004075:Diglycerides; D005419:Flavonoids; D012717:Sesquiterpenes; D016718:Arachidonic Acid; D002351:Carrageenan; D013755:Tetradecanoylphorbol Acetate