The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall.
We report the induction by topical minoxidil of increased fenestration in the perifollicular capillary wall. Male 30-day-old Wistar rats were divided into two groups, i.e. an experimental group which received 4% minoxidil solution topically on the dorsal skin, and a control group which received only vehicle solution topically. Using transmission electron microscopy, follicular and subepidermal capillaries and dermal fibres were compared between both groups. There were no obvious differences in subepidermal capillaries or dermal fibres between the two groups. However, topically applied minoxidil increased fenestration in follicular capillary walls around anagen hair bulbs.
Sakita
S
S
Department of Dermatology, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0152, Japan.
Kagoura
M
M
Toyoda
M
M
Morohashi
M
M
D000287:Administration, Topical; D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D018859:Hair Follicle / Q000098:blood supply* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008914:Minoxidil / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D008914:Minoxidil