title: [The weight of the spleen in chronic chagasics].
abstract: During the course of systemic inflammatory reactions and chronic venous congestion, the documented phenomenon of increased spleen size is respectively called reactional hyperplasia and congestive splenomegaly. In Chagas' disease, the inflammatory process observed in the heart of chronically infected patients can result in heart failure and ultimately in congestive failure. In order to evaluate the spleen response to both inflammatory and cardiac processes, in this retrospective study we compare the weight of spleens from normal and chagasic patients, with or without congestive failure. Information about patient age, sex, race and spleen weight was collected from autopsy reports. Eighty-eight selected cases were divided into four groups: 1) chagasic patients with congestive failure, 2) chagasic patients without congestive failure, 3) non-chagasic patients with congestive failure, 4) non-chagasic patients without congestive failure. The average age was 44.9 +/- 15.4 years, 53.4% were Caucasians and 70.5% were males, and no significant difference in these parameters was observed between the four groups. The spleen weight for the groups presenting congestive failure was 183.7 +/- 85.9 g for chagasic and 206.3 +/- 101.0 g for non-chagasic patients; for the groups without congestive failure the average spleen weight was 173.7 +/- 118.9 g for the chagasic and 117.2 +/- 52.0 g for non-chagasic patients. The spleen weight was significantly higher for the chagasic patients without congestive failure when compared to the non-chagasic group without congestive failure. These results suggest that the inflammatory component in Chagas' disease plays an important role in the increase of spleen weight together with hemodynamic alterations arising from congestive heart failure.
authors.affiliation: Disciplina de Patologia Geral, Universidade de Uberaba, Faculdade de Medicina do Triângulo Mineiro.
authors.forename: S A
authors.initials: SA
authors.lastname: Pereira
authors.forename: B S
authors.initials: BS
authors.lastname: Corrêa
authors.forename: G P
authors.initials: GP
authors.lastname: Minicucci
authors.forename: G M
authors.initials: GM
authors.lastname: Lopes
authors.forename: E C
authors.initials: EC
authors.lastname: Castro
authors.forename: M A
authors.initials: MA
authors.lastname: dos Reis
authors.forename: V de P
authors.initials: Vde P
authors.lastname: Teixeira
mesh_terms: D000328:Adult; D001344:Autopsy / Q000706:statistics & numerical data; D002598:Chagas Cardiomyopathy / Q000473:pathology; D014355:Chagas Disease / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology*; D018709:Statistics, Nonparametric