A comparative study of the calcium system in memory T cells and naive T cells.
The comparative analysis of responses of memory and naive T lymphocytes to Ca2+-mobilizing agents, namely Con A, thimerosal, thapsigargin and ionomycin, was carried out. The effect of these agents on both types of T cells differed qualitatively and quantitatively. The lack of intracellular Ca2+ stores in memory T cells was shown. Ca2+-mobilizing agents did not induce influx of Ca2+ in memory T cells from outside and this was the reason for their stability to Ca2+ ionophores. It was also shown that memory T cells were resistant to the 'Ca2+ paradox'.
Sigova
A
A
Institute of Cell Biophysics, Russian Academy of Sciences, Laboratory of Intracellular Signaling, Pushchino, Moscow region.
Dedkova
E
E
Zinchenko
V
V
Litvinov
I
I
D000818:Animals; D001692:Biological Transport; D020013:Calcium Signaling; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006706:Homeostasis; D007156:Immunologic Memory; D015759:Ionomycin / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D003208:Concanavalin A; D015759:Ionomycin