Human myeloma cells express the CD38 ligand CD31.
Multiple myeloma (MM) plasma cells (PC) are CD38+. A ligand for CD38 is the adhesion molecule CD31. By flow cytometry and immunocytochemistry we have investigated whether malignant PC co-express CD38 and CD31. All 68 patients studied were CD38+. 14/14 monoclonal gammopathies of undetermined significance (MGUS) and 39/39 plasmacytic MM patients co-expressed CD38 and CD31 at high density. Only 1/11 plasmablastic MM and 1/4 plasma cell leukaemias (PCL) expressed CD31. These data indicated that PC malignancies co-expressed high levels of both CD38 and its ligand CD31, with the exception of plasmablastic MM and PCL.
Vallario
A
A
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Chilosi
M
M
Adami
F
F
Montagna
L
L
Deaglio
S
S
Malavasi
F
F
Caligaris-Cappio
F
F
D015720:5'-Nucleotidase / Q000378:metabolism*; D000368:Aged; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*
D019408:Platelet Endothelial Cell Adhesion Molecule-1; D015720:5'-Nucleotidase