A comparison of the inhibition of ovulation achieved by desogestrel 75 micrograms and levonorgestrel 30 micrograms daily.
A randomized, double blind, group comparative study was performed over a 12 month period to compare inhibition of ovulation during the use of two (progestogen-only) oral contraceptives containing doses of 75 micrograms desogestrel or 30 micrograms levonorgestrel. Seventy-one female volunteers with regular cycles and established ovulation by ultrasonography and serum progesterone concentrations were recruited from an out-patient clinic in a university hospital and asked to participate in the study. Transvaginal ultrasonography and serum oestradiol, progesterone, luteinizing hormone (LH) and follicle stimulating hormone (FSH) measurements were performed throughout the 7th and 12th 28 day treatment period. Desogestrel at a dose of 75 micrograms showed a significant inhibition of ovulation compared to 30 micrograms levonorgestrel (P < 0.001).
Rice
C F
CF
Department of Obstetrics and Gynaecology, Princess Royal Hospital, Hull, UK.
Killick
S R
SR
Dieben
T
T
Coelingh Bennink
H
H
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D017135:Desogestrel / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000009:adverse effects; D010060:Ovulation / Q000187:drug effects*; D016896:Treatment Outcome
D003280:Contraceptives, Oral, Synthetic; D016912:Levonorgestrel; D017135:Desogestrel