Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein.
We have previously reported that Aleuria aurantia lectin (AAL)-reactive serum cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepatocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal controls (NC), and measurement of AAL-reactive ChE activity is useful in discriminating LC from CH. In the present study, we have demonstrated that the measurement of the ratio of AAL-reactive ChE to immuno-reactive ChE protein (AAL/ChE) is superior to the measurement of only AAL-reactive ChE for differentiating LC from CH. At a cut-off value of 4.0 arbitrary units of AAL/ChE, the diagnostic accuracy was 87.7%. This diagnostic accuracy is similar to that of serum hyaluronan, 88.8%. We also examined whether the AAL/ChE measurement is useful for differentiating Child's stage A LC from chronic active hepatitis (CAH) 2B. When mean + 2SD of AAL/ChE in patients with CAH2B was used as a cut-off value for the specific diagnosis of LC, the diagnostic accuracy was 70.2%. These results demonstrate that measurement of AAL/ChE is useful for discriminating LC from CH.
Hada
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Kondo
M
M
Yasukawa
K
K
Amuro
Y
Y
Higashino
K
K
D002802:Cholinesterases / Q000097:blood* / Q000378:metabolism; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006521:Hepatitis, Chronic / Q000175:diagnosis*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008103:Liver Cirrhosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D037102:Lectins; C064549:lectin, Aleuria aurantia; D002802:Cholinesterases