title: Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy.
abstract: We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Brien
authors.forename: E L
authors.initials: EL
authors.lastname: So
authors.forename: F B
authors.initials: FB
authors.lastname: Meyer
authors.forename: J E
authors.initials: JE
authors.lastname: Parisi
authors.forename: C R
authors.initials: CR
authors.lastname: Jack
mesh_terms: D000328:Adult; D001284:Atrophy; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male