New controlled-release ibuprofen tablets.
Tablets containing two different doses of ibuprofen are realized. The first possesses very fast release kinetics, while the second has slow and linear release kinetics. This allows drug to produce a therapeutic effect quickly and to maintain it for a long time with only one administration unit. Such tablets are obtained by compression of a mixture of two very different kinds of granulates: an ibuprofen-starch granulate and an ibuprofen-Eudragit RS microsphere granulate. Specific proportions of mixtures of them give the described result after compression at particular tablet hardnesses.
Palmieri
G F
GF
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Lovato
D
D
Martelli
S
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D007052:Ibuprofen