title: Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia.
abstract: Bone marrow necrosis (BMN) is a rare pathologic entity associated with a wide variety of diseases. We describe a patient with chronic myeloid leukemia on interferon treatment, who developed BMN with symptoms and signs masquerading as interferon toxicity. This is followed by a literature review of BMN in CML.
authors.affiliation: University Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong. jcschim@hkucc.hku.hk
authors.forename: C S
authors.initials: CS
authors.lastname: Chim
authors.forename: S K
authors.initials: SK
authors.lastname: Ma
authors.forename: C K
authors.initials: CK
authors.lastname: Lam
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology* / Q000628:therapy*; D008297:Male; D009336:Necrosis; D011994:Recombinant Proteins
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D006918:Hydroxyurea