Endocytosis: How dynamin sets vesicles PHree!
The dynamin GTPase is required for clathrin-dependent, receptor-mediated endocytosis. Exciting new studies have shown that dynamin's pleckstrin homology domain binds to phosphatidylinositol 4, 5-bisphosphate in vivo, thus localising dynamin directly at the plasma membrane and ultimately enabling vesiculation.
Bottomley
M J
MJ
Structural Biology Programme, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Lo Surdo
P
P
Driscoll
P C
PC
D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D003594:Cytoplasmic Granules; D019281:Dimerization; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism; D007425:Intracellular Membranes; D010750:Phosphoproteins
D001798:Blood Proteins; D010750:Phosphoproteins; C039077:platelet protein P47; D020558:GTP Phosphohydrolases; D034281:Dynamins