Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease.
Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.
Wood
W G
WG
Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center and the Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis 55417, USA.
Schroeder
F
F
Avdulov
N A
NA
Chochina
S V
SV
Igbavboa
U
U
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism
D002352:Carrier Proteins; D002784:Cholesterol