title: [Hepatonephritis and massive ingestion of buprenorphine].
abstract: We present a case of a severe hepatitis associated with acute renal failure and anuria consequently to the ingestion of 112 mg of buprenorphine, 48 hours before. The normalisation of hepatic and renal functions is associated with discontinuation of buprenorphine administration and hemodialysis treatment. Buprenorphine seems to be directly responsible for this hepatonephritis as indicated by the high plasmatic levels of buprenorphine (224 ng/ml) and norbuprenorphine (30 ng/ml) never described until now. Buprenorphine toxicity could be due to the inappropriate ingestion mode (oral instead of sublingual) and could be increased by previous acetaminophen intake.
authors.affiliation: U.F. de Toxicologie, Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Calmette-CHRU de Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Houdret
authors.forename: V
authors.initials: V
authors.lastname: Asnar
authors.forename: N
authors.initials: N
authors.lastname: Szostak-Talbodec
authors.forename: E
authors.initials: E
authors.lastname: Leteurtre
authors.forename: L
authors.initials: L
authors.lastname: Humbert
authors.forename: M
authors.initials: M
authors.lastname: Lecomte-Houcke
authors.forename: M
authors.initials: M
authors.lastname: Lhermitte
authors.forename: J C
authors.initials: JC
authors.lastname: Paris
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D000701:Analgesics, Opioid / Q000097:blood* / Q000506:poisoning*; D001706:Biopsy; D002047:Buprenorphine / Q000031:analogs & derivatives / Q000097:blood* / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008297:Male; D009393:Nephritis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006435:Renal Dialysis; D015813:Substance Abuse Detection / Q000379:methods*; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; C043585:norbuprenorphine