title: In vitro activities of pazufloxacin, a novel injectable quinolone, against bacteria causing infections in obstetric and gynecological patients.
abstract: T-3762 is an injectable new quinolone with a broad spectrum of antibacterial activity. Pazufloxacin (T-3761) is an active form of T-3762. The minimal inhibitory concentrations (MICs) of pazufloxacin for 50% of the clinical isolates tested were 3.13 microg/ml for Streptococcus agalactiae, 6.25 microg/ml for Gardnerella vaginalis, 0.025 microg/ml for Escherichia coli, 0.78 microg/ml for Pseudomonas aeruginosa, 6.25 microg/ml for Peptostreptococcus magnus, 6.25 microg/ml for Bacteroides fragilis and 12.5 microg/ml for Prevotella bivia. The MICs of T-3762 for 90% of the clinical isolates tested were 3.13 microg/ml for S. agalactiae, 6.25 microg/ml for G. vaginalis, 0.10 microg/ml for E. coli, 12.5 microg/ml for P. aeruginosa, 25 microg/ml for P. magnus, 12.5 microg/ml for B. fragilis and 25 microg/ml for P. bivia. The results of this study suggest that, subject to confirmation by clinical trials, T-3762, in combination with an agent with reliable activity against anaerobic bacteria, is suitable as an empirical therapy of patients with obstetric and gynecological infections.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Gifu City, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mikamo
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Hayasaki
authors.forename: K
authors.initials: K
authors.lastname: Kawazoe
authors.forename: T
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D024841:Fluoroquinolones; D006194:Gardnerella vaginalis / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010078:Oxazines / Q000494:pharmacology*; D010462:Peptostreptococcus / Q000187:drug effects; D018720:Prevotella / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013292:Streptococcus agalactiae / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D010078:Oxazines; C078052:pazufloxacin