title: Effect of high hydrostatic pressure on the porin OmpC from Escherichia coli.
abstract: Porin OmpC from Escherichia coli was reconstituted in liposomes and its gating kinetics were recorded at high hydrostatic pressure, up to 90 MPa, using a development of the patch clamp technique. The composition of the recording solution influenced the results but generally high hydrostatic pressure favoured channel opening.
authors.affiliation: Department of Biomedical Sciences, University of Aberdeen, UK. a.macdonald@abdn.ac.uk
authors.forename: A G
authors.initials: AG
authors.lastname: Macdonald
authors.forename: B
authors.initials: B
authors.lastname: Martinac
mesh_terms: D004926:Escherichia coli / Q000737:chemistry*; D006874:Hydrostatic Pressure; D015640:Ion Channel Gating; D007700:Kinetics; D008081:Liposomes; D018408:Patch-Clamp Techniques; D018272:Porins / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D008081:Liposomes; C113724:OmpC protein; D018272:Porins