Suppression of D-galactosamine-induced rat liver injury by glycosidic flavonoids-rich fraction from green tea.
Tea constituents that had a preventive effect on D-galactosamine-induced liver injury in rats were partially purified by column chromatography from a n-butanol-soluble fraction of green tea. The fraction containing glycosidic flavonoids was found to suppress the D-galactosamine-induced increase of plasma alanine aminotransferase and aspartate aminotransferase activities. These results indicate that glycosidic flavonoids contribute, at least in part, to the liver injury-preventive effect of green tea.
Wada
S
S
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
He
P
P
Watanabe
N
N
Sakata
K
K
Sugiyama
K
K
D000410:Alanine Transaminase / Q000096:biosynthesis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000096:biosynthesis; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000517:prevention & control*; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D005688:Galactosamine; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry*
D005419:Flavonoids; D013662:Tea; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase