Correlation between in vitro susceptibility determined by E test and response to therapy with amphotericin B: results from a multicenter prospective study of candidemia.
Ninety-nine Candida bloodstream isolates underwent testing for susceptibility to amphotericin B by the E test, and the results were correlated with patients' responses to amphotericin B. The MICs for isolates that were associated with therapeutic failure were significantly higher than the MICs for those associated with therapeutic success. A MIC of >/=0.38 microgram/ml identified isolates likely to be associated with therapeutic failure.
Clancy
C J
CJ
Department of Medicine, Division of Infectious Diseases, University of Florida College of Medicine, VA Medical Center, Gainesville, Florida, USA.
Nguyen
M H
MH
D000666:Amphotericin B / Q000494:pharmacology* / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies
D000935:Antifungal Agents; D000666:Amphotericin B