Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists.
The Suzuki reaction has been used to synthesize a variety of aryl-substituted heterocyclic antagonists of the CRH1 receptor. Examples with several different heterocyclic cores are potent CRH receptor ligands.
Cocuzza
A J
AJ
DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
Chidester
D R
DR
Culp
S
S
Fitzgerald
L
L
Gilligan
P
P
D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D006571:Heterocyclic Compounds; D018019:Receptors, Corticotropin-Releasing Hormone