[Treatment of dissociative symptoms in borderline patients with naltrexone].
Dissociative symptoms including flashbacks, i.e. vivid scenic recollections of traumatic episodes, in patients with Borderline Personality Disorder are a serious and often treatment-refractory problem. There is evidence suggesting changes in endogenous opioids in patients with Borderline Personality Disorder. Naltrexone, an opioid receptor antagonist, was administered to three female patients with Borderline Personality Disorder in a dosage of 50 mg (q.i.d.,p.o.) over several weeks. We observed a marked reduction in dissociative symptoms.
Schmahl
C
C
Abteilung für Psychiatrie und Psychotherapie, Universitätsklinik für Psychiatrie und Psychosomatik, Freiburg.
Stiglmayr
C
C
Böhme
R
R
Bohus
M
M
D000328:Adult; D001883:Borderline Personality Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use; D019954:Neurobehavioral Manifestations
D009292:Narcotic Antagonists; D009271:Naltrexone