title: Intrarectal artemisinin derivatives.
abstract: The artemisinin derivatives are the most potent antimalarials. They are rapidly absorbed orally, parenterally and intra-rectally. The latter mode of administration is particularly interesting in rural tropics. Preliminary studies have shown that artemisinin and its derivatives artesunate and artemether are effective when given intrarectally. More studies are needed to establish the optimum regimen.
authors.affiliation: Faculty of Tropical Medicine, Madihol University, Bangkok, Thailand. nosten@cm.ksc.co.th
authors.forename: F
authors.initials: F
authors.lastname: Nosten
authors.forename: M
authors.initials: M
authors.lastname: van Vugt
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000042:Absorption; D000285:Administration, Rectal; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D000077549:Artemether; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology; D008657:Metabolic Clearance Rate; D012717:Sesquiterpenes / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013488:Suppositories
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D013488:Suppositories; D000077332:Artesunate; C031327:artemisinin; D000077549:Artemether