[Metabolism of 123I-IBF in humans].
The metabolism of 123I-IBF in humans has been studied in vivo and in vitro to evaluate the quantitative analysis of dopamine D2 receptor. 123I-IBF was rapidly metabolized in humans following i.v. administration. 123I-nor-ox-IBF, 123I-ox-IBF, 123I-nor-IBF and various unidentified metabolites were found in the plasma and urine. Slight deiodination of 123I-IBF occurred following i.v. administration. The major metabolites were detected using in vitro human P450 gene expression systems. These results indicate that 123I-IBF is enzymatically metabolized in the liver and rapidly excreted in the urine. In addition, the chemical structures of the identified plasma metabolites suggest that these metabolites do not cross the blood-brain barrier.
Matsumoto
H
H
Research Center, Nihon Medi-Physics Co., Ltd., Chiba.
Tanaka
A
A
Suzuki
N
N
Kondo
S
S
KatoAzuma
M
M
Yonekura
Y
Y
D000328:Adult; D001572:Benzofurans / Q000378:metabolism* / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011759:Pyrrolidines / Q000378:metabolism* / Q000493:pharmacokinetics*
D001572:Benzofurans; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; C062439:5-iodo-N-((1-ethyl-2-pyrrolidinyl)methyl)-2,3-dihydrobenzofurancarboxamide; D003577:Cytochrome P-450 Enzyme System