Complete histological regression of Kaposi's sarcoma following treatment with protease inhibitors despite persistence of HHV-8 in lesions.
There is no current curative treatment for HIV-related Kaposi's sarcoma. The identification of human herpesvirus-8 as a possible aetiological agent suggests potential efficacy of anti-viral agents. We report here on the complete histological remission of Kaposi's sarcoma following treatment with protease inhibitors, even in patients with limited virological response and persistence of HHV-8.
Benfield
T L
TL
Department of Infectious Diseases, Hvidovre Hospital, Denmark.
Kirk
O
O
Elbrønd
B
B
Pedersen
C
C
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000473:pathology; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D017320:HIV Protease Inhibitors; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir