Paraproteins and monoclonal expansion of CD3+CD8+ CD56-CD57+ T lymphocytes in a patient with HIV infection.
An expansion of CD8+ lymphocytes associated with a monoclonal rearrangement of the T-cell receptor gamma locus was found in a woman with HIV-1 infection. A subpopulation of HIV-positive patients display an unusual response to HIV infection characterized by a persistent marked CD8+ lymphocytosis, the presence of which appears to be associated with an improved long-term prognosis. This condition is thought to represent a florid immune response to an ongoing viral infection which may be HIV itself, and suggests that monoclonal proliferation of CD8+ lymphocytes does not imply the presence of an underlying malignant process.
Smith
P
P
Department of Genitourinary Medicine, Royal Hositals NHS Trust, Whitechapel, London.
Helbert
M
M
Raftery
M
M
Forster
G
G
Cavenagh
J
J
D015703:Antigens, CD / Q000276:immunology*; D018956:CD5 Antigens / Q000276:immunology; D019002:CD56 Antigen / Q000276:immunology; D018959:CD57 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000172:deficiency / Q000276:immunology; D008218:Lymphocytosis / Q000276:immunology* / Q000821:virology; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology
D015703:Antigens, CD; D018956:CD5 Antigens; D019002:CD56 Antigen; D018959:CD57 Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016692:Receptors, Antigen, T-Cell, gamma-delta