title: A feasibility study of continuous hyperfractionated accelerated radiotherapy (CHART) and brachytherapy in patients with early oral or oropharyngeal carcinomas.
abstract: Overall time is important in the curative treatment of head and neck cancer (Dische, S., Saunders, M.I., Barrett, A., Harvey, A., Gibson, D., Parmar, M., 1997, Radiother. Oncol., 44:123-136). Results are presented on outcome and morbidity in ten patients with head and neck cancer treated with external beam irradiation (CHART protocol) and interstitial implantation, completing treatment in 12 days. Local control and overall survival at 5 years was 67%. Acute and late morbidity was acceptable giving scope for dose escalation.
authors.affiliation: Marie Curie Research Wing, Mount Vernon Hospital, Northwood, Middlesex, UK.
authors.forename: K
authors.initials: K
authors.lastname: Goodchild
authors.forename: P
authors.initials: P
authors.lastname: Hoskin
authors.forename: S
authors.initials: S
authors.lastname: Dische
authors.forename: K
authors.initials: K
authors.lastname: Pigott
authors.forename: M
authors.initials: M
authors.lastname: Powell
authors.forename: M
authors.initials: M
authors.lastname: Saunders
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D002588:Cesium Radioisotopes / Q000627:therapeutic use; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D015993:Life Tables; D008198:Lymph Nodes / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000209:etiology; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D013280:Stomatitis / Q000209:etiology; D015996:Survival Rate; D013997:Time Factors
chemical_list: D002588:Cesium Radioisotopes; D007496:Iridium Radioisotopes; D019275:Radiopharmaceuticals