Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy.
We report on a 28-year-old man with long-standing intractable complex partial and secondary generalized seizures, whose magnetic resonance imaging scans 4 years apart documented progressive decrease in the left hippocampal volume. Left anterior temporal lobectomy with amygdalohippocampectomy rendered the patient seizure free at 12 months' follow-up. The findings demonstrate that patients with uncontrolled temporal lobe seizures may develop progressive atrophy of the hippocampus, in the absence of status epilepticus.
O'Brien
T J
TJ
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
So
E L
EL
Meyer
F B
FB
Parisi
J E
JE
Jack
C R
CR
D000328:Adult; D001284:Atrophy; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male