Effect of renal transplantation (surgical stress) on serum levels of oxidants and reducing system.
BACKGROUND
This study attempts to understand the correlation (if any) between surgical stress of renal transplantation and serum levels of pro-oxidant/antioxidants.


METHODS
Twenty-four ESRD patients having undergone transplant surgery followed from day-1 to day-10 postsurgery were investigated for serum levels of MDA, SOD, Vit. C and E. The drug regimen received was immunosuppressant, H2 blockers and antihypertensives as per the situation.


RESULTS
The typical observations indicated elevated serum levels of MDA from preoperative stage reaching peak value 24 hrs after surgery followed by a steady fall and achieving minima on the 10th day. As regards antioxidants enzyme SOD, Vit. C, Vit. E were low from pretransplant day reaching minima 24 hours postoperatively and returning to normal from 7th day.


CONCLUSIONS
The present investigation has amply shown a typical imbalance between pro-oxidant/antioxidants from pretransplant day up to 24 hrs and there after returning to normal level from 7th day suggestive to desired recovery and surgical stress not a limiting factor in way of health progress renal transplant. Dietary intake of Vit. C and E in mega doses can be a good therapeutic measure.
Rajbala
A
A
Department of Laboratory Medicine (Biochemistry), Institute of Kidney Diseases and Research Centre, Ahmedabad, India.
Sane
A S
AS
Shah
P R
PR
Mishra
V V
VV
Patel
S M
SM
Shah
S A
SA
Shah
V R
VR
Trivedi
H L
HL
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D016030:Kidney Transplantation; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D013312:Stress, Physiological / Q000097:blood*
D000975:Antioxidants; D016877:Oxidants