Allogeneic bone marrow transplantation of chronic myeloid leukemia from an HLA-matched unrelated donor with the beta-thalassemic trait.
We report a chronic myeloid leukemia patient who underwent allogeneic bone marrow transplantation from an HLA-matched unrelated donor with the beta-thalassemic trait. The donor was a heterozygote for the -28 A-->G mutation. We examined the recipient's bone marrow and peripheral blood using the polymerase chain reaction (PCR) method to detect the -28 G-->A mutation of the donor type and monitored the sustained engraftment. This case suggests that a donor with the thalassemic trait can be a candidate for matched unrelated bone marrow transplantation for hematological malignancies and that PCR based genetic examination of the thalassemic mutation is a useful tool to detect early engraftment.
Sue
Y C
YC
Department of Internal Medicine, Kaohsiung Medical College Hospital, Taiwan.
Liu
T C
TC
Chang
C S
CS
Huang
S M
SM
Chen
T P
TP
Lin
S F
SF
D000328:Adult; D016026:Bone Marrow Transplantation; D004608:Eligibility Determination; D006085:Graft Survival; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D014019:Tissue Donors / Q000145:classification; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000235:genetics*