title: Multi-component methodologies in solid-phase organic synthesis.
abstract: Solid-phase organic synthesis, particularly when used in conjunction with combinatorial techniques, is emerging as a revolutionary technology in chemistry. Multi-component reaction systems are particularly valued because several elements of diversity can be introduced in a single transformation thereby expanding the diversity of compound libraries. A variety of multi-component reactions have been successfully adapted for solid-phase technology as described in this review.
authors.affiliation: Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Dax
authors.forename: J J
authors.initials: JJ
authors.lastname: McNally
authors.forename: M A
authors.initials: MA
authors.lastname: Youngman
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D013678:Technology, Pharmaceutical / Q000639:trends*