Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers.
Genetically determined differences in interleukin-10 (IL-10) and gamma interferon (IFN-gamma) responses in mice correlate with clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IFN-gamma and additional cytokine genes in patients who had recent-onset Chlamydia-associated arthritis (Chl-AA). IL-10 and IFN-gamma mRNA were relatively abundant in recent-onset Chl-AA.
Kotake
S
S
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Schumacher
H R
HR
Arayssi
T K
TK
Gérard
H C
HC
Branigan
P J
PJ
Hudson
A P
AP
Yarboro
C H
CH
Klippel
J H
JH
Wilder
R L
RL
D000328:Adult; D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000276:immunology; D001170:Arthritis, Infectious / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D016022:Case-Control Studies; D002689:Chlamydia / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D002690:Chlamydia Infections / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D016207:Cytokines / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D015870:Gene Expression; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D051379:Mice; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013583:Synovial Membrane / Q000276:immunology
D016207:Cytokines; D004269:DNA, Bacterial; D012333:RNA, Messenger; D016753:Interleukin-10; D007371:Interferon-gamma