Effect of neutron-gamma radiation on dopamine and serotonin metabolism in the rat brain: a regional analysis.
The concentrations of dopamine (DA) and its metabolites and the levels of 5-hydroxyindoleacetic acid (5-HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron-gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5-HIAA levels was noted.
Foulon
O
O
Department of Radiobiology, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France.
Lalouette
F
F
Lambert
F
F
Martin
S
S
Fatôme
M
M
Martin
C
C
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D003342:Corpus Striatum / Q000528:radiation effects; D004298:Dopamine / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D005625:Frontal Lobe / Q000528:radiation effects; D005720:Gamma Rays; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000528:radiation effects; D008297:Male; D009502:Neutrons; D009714:Nucleus Accumbens / Q000528:radiation effects; D009928:Organ Specificity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D013378:Substantia Nigra / Q000528:radiation effects
D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid