Homologation of alpha-amino acids to beta-amino acids using Fmoc-amino acid pentafluorophenyl esters.
The homologation of alpha-amino acids to beta-amino acids by the two-step Arndt-Eister method is achieved by using Fmoc-alpha-amino acid pentafluorophenyl esters for the acylation of diazomethane, synthesizing the key intermediates Fmoc-aminoacyldiazomethanes as crystalline solids in good yields and purity.
Babu
V V
VV
Department of Studies in Chemistry, Central College Campus, Bangalore University, India.
Gopi
H N
HN
Ananda
K
K
D000596:Amino Acids / Q000138:chemical synthesis*; D003978:Diazomethane / Q000737:chemistry; D004952:Esters / Q000737:chemistry*; D008956:Models, Chemical
D000596:Amino Acids; D004952:Esters; D003978:Diazomethane