Functional analysis of the roles of FliQ and FlhB in flagellar expression in Helicobacter pylori.
Expression of the two Helicobacter pylori flagellin proteins FlaA and FlaB is required for full motility and persistent infection of the gastric mucosa. The mechanisms and regulation of the biosynthesis and export of flagella in H. pylori are still poorly understood. Scrutiny of the H. pylori 26695 genome sequence revealed homologues of FliQ and FlhB. The roles of the fliQ and flhB genes in H. pylori were investigated by the construction and characterisation of defined isogenic mutants. The results indicate that these genes are involved in the flagellar expression, adhesion to and colonisation of the gastric mucosa.
Foynes
S
S
Department of Medical Microbiology, St. Bartholomew's, West Smithfield, London, UK.
Dorrell
N
N
Ward
S J
SJ
Zhang
Z W
ZW
McColm
A A
AA
Farthing
M J
MJ
Wren
B W
BW
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D005407:Flagella / Q000235:genetics*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D008124:Locomotion / Q000235:genetics*; D008565:Membrane Proteins; D051379:Mice; D009154:Mutation
D001426:Bacterial Proteins; C085668:FlhB protein, Bacteria; D008565:Membrane Proteins; C074891:FliQ protein, Bacteria