Iron transport across biologic membranes.
Iron is essential for life, but is toxic in excess. Nearly all organisms have therefore developed regulated mechanisms for efficient transport of iron into cells. This paper reviews the current understanding of iron transport, focusing on valuable lessons from studies of yeast iron transport and the discovery of the first mammalian transmembrane iron transporter.
Andrews
N C
NC
Howard Hughes Medical Institute, Children's Hospital, Boston, MA 02115, USA.
Fleming
M D
MD
Gunshin
H
H
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics*; D027682:Cation Transport Proteins; D038181:FMN Reductase; D015870:Gene Expression; D006801:Humans; D007501:Iron / Q000378:metabolism / Q000493:pharmacokinetics* / Q000502:physiology* / Q000633:toxicity; D033862:Iron-Binding Proteins; D008564:Membrane Potentials; D009154:Mutation; D009247:NADH, NADPH Oxidoreductases / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D000099236:Solute Carrier Family 11, Member 2
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D038181:FMN Reductase; D007501:Iron; D033862:Iron-Binding Proteins; D009247:NADH, NADPH Oxidoreductases; D000099236:Solute Carrier Family 11, Member 2; C023903:ferric citrate iron reductase