Synthesis and antitumor activities of water-soluble benzoylphenylureas.
Water-soluble benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. Some of the prodrugs were highly soluble in water and showed good antitumor activities against P388 leukemia cells in mice when injected intravenously.
Okada
H
H
Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Shiga, Japan.
Kato
M
M
Koyanagi
T
T
Mizuno
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007275:Injections, Intravenous; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010671:Phenylurea Compounds / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D012995:Solubility
D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D011355:Prodrugs