Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura.
Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.
Zent
C S
CS
Section of Hematology/Oncology, Department of Internal Medicine, University of Chicago, Illinois, USA.
Ratajczak
J
J
Ratajczak
M Z
MZ
Anastasi
J
J
Hoffman
P C
PC
Gewirtz
A M
AM
D000328:Adult; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000473:pathology*; D013926:Thrombopoietin / Q000097:blood*
D013926:Thrombopoietin