Diabetic gustatory sweating successfully treated with topical glycopyrrolate: report of a case and review of the literature.
BACKGROUND
Gustatory sweating is a more common manifestation of diabetes mellitus than is appreciated. It is a distressing problem that has been difficult to treat safely.


METHODS
Daily topical application of glycopyrrolate roll-on lotion was offered as an alternative to oral anticholinergic agents to an 87-year-old woman with long-standing type 2 diabetes mellitus who complained of profuse sweating after eating.


RESULTS
Gustatory sweating was relieved by application of glycopyrrolate and reappeared when the glycopyrrolate was briefly withdrawn to confirm its therapeutic effect.


CONCLUSIONS
For moderate to severe symptoms of diabetic gustatory sweating, topical application of glycopyrrolate is safe, effective, well tolerated, and convenient.
Urman
J D
JD
Department of Medicine, Kaiser Permanente Medical Center, Mountain View, California, USA. jeffrey.urman@ncal.kaiperm.org
Bobrove
A M
AM
D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000008:administration & dosage / Q000627:therapeutic use*; D013547:Sweating, Gustatory / Q000188:drug therapy* / Q000209:etiology
D018727:Muscarinic Antagonists; D010276:Parasympatholytics; D006024:Glycopyrrolate