Immunomodulation in transplant patients by cryofiltration.
Cryofiltration was applied to major ABO incompatible bone marrow transplant (BMT), renal transplant, and chronic renal rejection cases. The anti-ABO titers IgM and IgG pretreatment by cryofiltration were x64 and x8 in a major ABO incompatible BMT patient. After treatments, they were decreased to x16 and x2, respectively. BMT was performed successfully. In a case of ABO major incompatible renal transplant, anti-A-IgM before cryofiltration treatment was x128, and CH50 was 26.5. Three treatments were performed. As a result, the anti-A-IgM and CH50 levels were decreased to x4 and under 10. After renal transplantation, antibodies appeared again, but because the creatinine level was normal, cryofiltration was not performed again. Five cases of chronic rejection of renal transplants were treated by cryofiltration. They remained hemodialysis (HD) free for an average of 17.4 months, and the longest duration was 32 months. Cryofiltration is a good treatment for extracorporeal immunomodulation in transplantation.
Kawamura
A
A
Osanai
M
M
Yonekawa
M
M
D000017:ABO Blood-Group System; D000327:Adsorption; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D000925:Anticoagulants / Q000627:therapeutic use; D001787:Blood Group Incompatibility / Q000628:therapy; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D017679:Cryotherapy; D005782:Gels; D006084:Graft Rejection / Q000628:therapy; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods*; D006435:Renal Dialysis
D000017:ABO Blood-Group System; D000925:Anticoagulants; D005782:Gels; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D006493:Heparin