Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides.
This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The pharmacodynamic relationships between biodistribution and the ultimate biological effects of antisense agents are considered. The problems and advantages inherent in the use of delivery systems are discussed in the light of further enhancing in vivo pharmacological actions of oligonucleotides.
Juliano
R L
RL
Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA. arjay@med.unc.edu
Alahari
S
S
Yoo
H
H
Kole
R
R
Cho
M
M
D000818:Animals; D001692:Biological Transport; D002478:Cells, Cultured; D016503:Drug Delivery Systems; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D014018:Tissue Distribution
D016376:Oligonucleotides, Antisense