The role of the proteasome system and the proteasome activator PA28 complex in the cellular immune response.
The generation of antigenic peptides bound and presented to the immune system by MHC class I molecules predominantly depends on the function of the proteasome system. Stimulation of cells with interferon gamma induces the incorporation of three active site bearing beta-subunits into the 20S proteasome and the formation of the PA28 proteasome modulator complex. PA28 alters the cleavage properties of the proteasome and enhances MHC class I antigen presentation. Thus, by cytokine induced change of the proteasome system cells may alter the proteolytic properties of the 20S proteasome and may render an organism more flexible in its peptide generation capacity.
Kloetzel
P M
PM
Institut für Biochemie-Charité, Humboldt-Universität zu Berlin, Germany.
Soza
A
A
Stohwasser
R
R
D003546:Cysteine Endopeptidases / Q000276:immunology*; D004789:Enzyme Activation; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000276:immunology; D009097:Multienzyme Complexes / Q000276:immunology*; D009124:Muscle Proteins; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000276:immunology*; D014611:Vaccination
D015395:Histocompatibility Antigens Class I; D009097:Multienzyme Complexes; D009124:Muscle Proteins; C085047:PSME1 protein, human; D011506:Proteins; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex