Inhibition of lipopolysaccharide (LPS)-induced endothelial cytotoxicity by diosmin.
The cytotoxic effect of lipopolysaccharide (LPS) on cultivated bovine aortic endothelial cells was determined. This LPS-induced cytotoxicity was attenuated by diosmin. That means, the IC50 value of LPS in the combination with 8 mumol/l diosmin was shifted from 31 to 70 ng/ml in a concentration dependent manner. As a hypothesis it was suggested, that the inhibition of LPS-induced cytotoxicity in bovine aortic endothelial cell cultures by diosmin could be probably mediated via inhibition of tyrosine kinases.
Melzig
M F
MF
Institute of Pharmacy, Humboldt-University Berlin, Germany. matthias=melzig@pharma.hu-herlin.de
Loose
R
R
D000818:Animals; D002417:Cattle; D002460:Cell Line; D004145:Diosmin / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000633:toxicity
D008070:Lipopolysaccharides; D004145:Diosmin