Studies of antibacterial activity of binuclear rhodium (II) complexes with heterocyclic nitrogen ligands.
Binuclear rhodium (II) complexes, [Rh2(OOCPh)2(phen)2(H2O)2] (OOCPh)2 (1), [Rh2(OOCPh)2(bpy)2(H2O)2] (OOCPh)2 (2), [Rh2(OOCBu(n))2 (bpy)2(H2O)2] (OOCBu(n)2 (3), and [Rh2(OOCPr(n)2 (phen)2(H2O)2] (OOCPr(n)2 (4) (Phen = 1,10-phenanthroline and bpy = 2,2'-bipyridine), have been synthesized and characterized using NMR, IR and electronic spectra. Activity of these compounds against Gram-positive bacteria decreases in the order: 1?2?3 > 4. Complex 1 is active against many Staphylococcus strains resistant to commonly used antibiotics. The complexes 1-4 are much less active agents against Gram-negative bacteria.
Bień
M
M
Institute of Microbiology, University of Wrocław, Poland.
Pruchnik
F P
FP
Seniuk
A
A
Lachowicz
T M
TM
Jakimowicz
P
P
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008027:Light; D008826:Microbial Sensitivity Tests; D009584:Nitrogen / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D012238:Rhodium; D009584:Nitrogen