[Anti-HIV-1 genes; genetic restriction of AIDS pathogenesis by gene variants].
Three genes which have variants acting as anti-HIV-1 were described so far. Among three, two are genes encoding receptors for chemokines, namely CCR5 and CCR2, which act as entry coreceptors for HIV-1 virus. The other gene is SDF1 gene. SDF-1, a cytokine belonging to the chemokine family has an inhibitory activity against the HIV-1 infection, because SDF-1 Is the physiological ligand for CXCR4, the entry coreceptor for T tropic HIV-1 virus. Recently, an SDF1 gene polymorphism was figured out to be one of the human genetic factors which regulate the period between the HIV-1 infection and the AIDS onset. By this finding, it was strongly suggested that SDF-1 regulates the onset of AIDS in the actual human population.
Tashiro
K
K
Center for Molecular Biology and Genetics, Kyoto University.
Ikegawa
M
M
Yabe
D
D
Honjo
T
T
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics; D015497:HIV-1; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D011110:Polymorphism, Genetic; D019707:Receptors, Chemokine / Q000235:genetics
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019707:Receptors, Chemokine