Resection guided by antibodies (REGAJ) a reappraisal after 10 years.
Between 1986 and 1990 50 patients with ovarian cancer were submitted to a procedure which we called REGAJ-resection guided by antibodies. Using the radiolabelled murine monoclonal antibody OC 125, microscopic ovarian tumors producing CA 125 were detected during second-look surgery by a hand-held probe. Retrospective analysis after 10 years revealed that this procedure resulted in the cure of 4 of 11 patients, who would otherwise have been considered tumor free during second-look surgery and not further treated. Previous problems associated with the method can now be solved so that the clinical value of the procedure should be reconsidered.
Jäger
W
W
Department of Obstetrics and Gynecology, University of Erlangen-Nuremberg-Germany.
Ackermann
S
S
D000818:Animals; D000911:Antibodies, Monoclonal; D018394:CA-125 Antigen / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D016343:Monitoring, Intraoperative / Q000379:methods; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D016719:Radioimmunodetection / Q000379:methods*; D016019:Survival Analysis; D013997:Time Factors
D000911:Antibodies, Monoclonal; D018394:CA-125 Antigen; D007457:Iodine Radioisotopes