Signal transduction in keratinocytes.
Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which cells (keratinocytes) respond to extracellular signals, is changing in protein phosphorylation. The protein phosphorylation is a consequence of the ligand/receptor binding which leads to activation of several transduction systems. In this review we emphasize on different signal transduction pathways in keratinocytes (tyrosine kinases, PKA, PKC, MAPK, casein kinase 2 etc.).
Mitev
V
V
Department of Biochemistry, Faculty of Medicine, Medical University of Sofia, Bulgaria. mitev@ns.medfac.acad.bg
Miteva
L
L
D000818:Animals; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D008954:Models, Biological; D010740:Phospholipases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D018121:Receptors, Cytokine / Q000502:physiology; D015398:Signal Transduction
D018121:Receptors, Cytokine; D011494:Protein Kinases; D010740:Phospholipases