title: Localized scleroderma associated with progressing ischemic stroke.
abstract: We present a 73 year-old Japanese woman with localized scleroderma involving the right side of the scalp accompanied by continuous tingling pain, who developed insidiously progressive left hemiparesis. In magnetic resonance imaging of the brain, an infarct first appeared in the watershed region of the right middle cerebral artery territory and subsequently extended to deep white matter accompanied by scattered hemorrhages. Focal stenosis in the M2 portion of the right middle cerebral artery was revealed on magnetic resonance angiography, and the distal vessels were only shown faintly. A biopsy specimen from the sclerotic scalp lesion showed obvious thickening of vessel walls and mild mononuclear cell infiltration. We believe that the progressing ischemic stroke was caused by hemodynamic disturbances from localized sclerotic obstruction of the middle cerebral artery, with an autoimmune pathogenesis.
authors.affiliation: Department of Neurology, National Okinawa Hospital, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kanzato
authors.forename: T
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Y
authors.initials: Y
authors.lastname: Komine
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Yoshio
authors.forename: M
authors.initials: M
authors.lastname: Suehara
mesh_terms: D000368:Aged; D001160:Arterioles / Q000473:pathology; D001921:Brain / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002544:Cerebral Infarction / Q000150:complications* / Q000175:diagnosis; D003094:Collagen / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D012535:Scalp / Q000473:pathology; D012594:Scleroderma, Localized / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
chemical_list: D003094:Collagen