Quantitative analysis of interleukin 6 (IL-6) in patients with IgA nephropathy after tonsillectomy.
The biological response to tonsillectomy was studied in 21 patients suffering from chronic tonsillitis with or without IgA nephropathy (IgAN). Serum and urinary interleukin-6 (IL-6) levels were measured before and after tonsillectomy. Serum IL-6 levels in case of IgAN peaked 3 h after tonsillectomy and more rapidly than control cases. No significant differences were observed between two cases through the time. Urinary IL-6 levels were significantly higher before and at 6 and 48 h after tonsillectomy in IgAN cases. Stimulation of tonsils caused serum IL-6 elevation and changes in urinary IL-6 levels in IgAN cases. Elevation of urinary IL-6 levels after tonsillectomy in patients with IgAN may reflect an increase in the production of IL-6 in the kidneys. Measurement of urinary IL-6 levels after tonsillectomy is useful to elucidate the efficacy of tonsillectomy in IgAN patients.
Baba
Y
Y
Department of Otolaryngology, Okayama University Medical School, Japan.
Akagi
H
H
Fukushima
K
K
Kosaka
M
M
Hattori
K
K
Nishizaki
K
K
Ogawa
T
T
Masuda
Y
Y
Shikata
K
K
D000293:Adolescent; D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007677:Kidney Function Tests; D008297:Male; D014066:Palatine Tonsil / Q000276:immunology; D011183:Postoperative Complications / Q000175:diagnosis* / Q000276:immunology; D014068:Tonsillectomy; D014069:Tonsillitis / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome
D015850:Interleukin-6