title: Role of red blood cells in pharmacokinetics of chemotherapeutic agents.
abstract: After oral or parenteral administration of chemotherapeutic agents, these drugs are transported to the tissues by the blood in different fractions: plasma water, plasma proteins or cells. In this review, the role of the red blood cell in storage, transport and metabolism of different anti-cancer drugs is described.
authors.affiliation: Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium. Dirk.Schrijvers@uza.uia.ac.be
authors.forename: D
authors.initials: D
authors.lastname: Schrijvers
authors.forename: M
authors.initials: M
authors.lastname: Highley
authors.forename: E
authors.initials: E
authors.lastname: De Bruyn
authors.forename: A T
authors.initials: AT
authors.lastname: Van Oosterom
authors.forename: J B
authors.initials: JB
authors.lastname: Vermorken
mesh_terms: D000284:Administration, Oral; D018943:Anthracyclines / Q000097:blood; D000903:Antibiotics, Antineoplastic / Q000097:blood; D000970:Antineoplastic Agents / Q000097:blood* / Q000493:pharmacokinetics; D001215:Asparaginase / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity; D004317:Doxorubicin / Q000097:blood; D015251:Epirubicin / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005472:Fluorouracil / Q000097:blood; D006801:Humans; D007069:Ifosfamide / Q000097:blood; D007263:Infusions, Parenteral; D015122:Mercaptopurine / Q000097:blood; D008727:Methotrexate / Q000097:blood; D017239:Paclitaxel / Q000097:blood; D017671:Platinum Compounds / Q000493:pharmacokinetics
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D017671:Platinum Compounds; D015251:Epirubicin; D004317:Doxorubicin; D015122:Mercaptopurine; D001215:Asparaginase; D017239:Paclitaxel; D005472:Fluorouracil; D007069:Ifosfamide; D008727:Methotrexate