title: T-cell-rich B-cell non-Hodgkin's lymphoma mimicking Hodgkin's disease.
abstract: We report on a patient with recurrent T-cell-rich B-cell lymphoma (TCRBCL), initially misdiagnosed as a lymphocyte-rich Hodgkin's disease. This case exemplifies the diagnostic problems of TCRBCL and the need for immunophenotypic analysis to differentiate TCRBCL from Hodgkin's disease, nodular paragranuloma and peripheral T-cell lymphoma. A rather unusual aspect is the long disease-free interval between the excision of the node in and the late relapse in 1996. The significance of the abundant T-cell infiltration in this B-cell neoplasm will be discussed and the concepts concerning antitumor response will be reviewed. Based on epidemiological data and the clinical behaviour TCRBCL does not seem to represent a distinctive pathological entity.
authors.affiliation: Institute of Medical Oncology, Inselspital, University of Berne, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Bättig
authors.forename: E
authors.initials: E
authors.lastname: Mueller-Garamvoelgyi
authors.forename: S B
authors.initials: SB
authors.lastname: Cogliatti
authors.forename: U
authors.initials: U
authors.lastname: Schmid
authors.forename: A
authors.initials: A
authors.lastname: Kappeler
authors.forename: T
authors.initials: T
authors.lastname: Cerny
authors.forename: J A
authors.initials: JA
authors.lastname: Laissue
authors.forename: M F
authors.initials: MF
authors.lastname: Fey
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015703:Antigens, CD; D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide