title: Parathyroid and thyroid function five years after treatment of laryngeal and hypopharyngeal carcinoma.
abstract: The proximity of the thyroid and parathyroid glands to the larynx and hypopharynx puts them at risk from treatment of squamous cell carcinoma (SCC) of this region. Consequently parathyroid and thyroid function was evaluated in patients surviving at least 5 years following treatment of primary SCC of the larynx or hypopharynx. Twenty-eight patients, initially treated from 1990 to 1992, were assessed and divided into four groups according to treatment received. Hypoparathyroidism (partial and hypocalcaemic) occurred in 88% and hypothyroidism (clinical and subclinical) in 50% in Group 1 (radiotherapy only) Group 2 (salvage laryngectomy for failed radiotherapy) had 66% hypoparathyroid and 33% hypothyroid. Group 3 (surgery + radiotherapy combined) had 89% hypoparathyroid and 89% hypothyroid. Group 4 (surgery only) had 63% hypoparathyroid and 63% hypothyroid. Significant endocrine hypofunction therefore occurs following the treatment of laryngopharyngeal carcinoma, more so with radiotherapy and combined therapy than with surgery alone.
authors.affiliation: Department of Otolaryngology, University of Cape Town, South Africa.
authors.forename: M A
authors.initials: MA
authors.lastname: Thorp
authors.forename: N S
authors.initials: NS
authors.lastname: Levitt
authors.forename: S
authors.initials: S
authors.lastname: Mortimore
authors.forename: S
authors.initials: S
authors.lastname: Isaacs
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007011:Hypoparathyroidism / Q000175:diagnosis; D007012:Hypopharyngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D011182:Postoperative Care; D011446:Prospective Studies; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D013963:Thyroid Hormones