title: Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus.
abstract: We report a case of diffuse necrobiosis lipoidica (NL) which first appeared on the legs and scrotum, before gradually spreading across the back and arms; the patient also suffered from diabetes mellitus, and the NL lesion began to disappear as the diabetes mellitus was controlled. The possible contribution of various glycation and glycoxidation products of collagen to the pathogenesis of NL is discussed.
authors.affiliation: Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Imakado
authors.forename: H
authors.initials: H
authors.lastname: Satomi
authors.forename: M
authors.initials: M
authors.lastname: Iskikawa
authors.forename: M
authors.initials: M
authors.lastname: Iwata
authors.forename: Y
authors.initials: Y
authors.lastname: Tsubouchi
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D003094:Collagen / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017127:Glycation End Products, Advanced; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000209:etiology*; D012611:Scrotum
chemical_list: D017127:Glycation End Products, Advanced; D003094:Collagen