Comparison of in vitro activity of liposomal nystatin against Aspergillus species with those of nystatin, amphotericin B (AB) deoxycholate, AB colloidal dispersion, liposomal AB, AB lipid complex, and itraconazole.
We compared the in vitro activity of liposomal nystatin (Nyotran) with those of other antifungal agents against 60 Aspergillus isolates. Twelve isolates were itraconazole resistant. For all isolates, geometric mean (GM) MICs (micrograms per milliliter) were 2.30 for liposomal nystatin, 0.58 for itraconazole, 0.86 for amphotericin B (AB) deoxycholate, 9.51 for nystatin, 2.07 for liposomal AB, 2.57 for AB lipid complex, and 0.86 for AB colloidal dispersion. Aspergillus terreus (GM, 8.72 micrograms/ml; range, 8 to 16 micrograms/ml) was significantly less susceptible to all of the polyene drugs than all other species (P = 0.0001).
Oakley
K L
KL
Department of Medicine, Hope Hospital, Salford, Manchester M8 6RB, United Kingdom.
Moore
C B
CB
Denning
D W
DW
D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D001230:Aspergillus / Q000187:drug effects*; D003840:Deoxycholic Acid / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D017964:Itraconazole / Q000008:administration & dosage*; D008055:Lipids; D008081:Liposomes; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000008:administration & dosage*
D000935:Antifungal Agents; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D003840:Deoxycholic Acid; D009761:Nystatin; D017964:Itraconazole; D000666:Amphotericin B