title: Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by Chlorella.
abstract: Chlorella pyrenoidosa Chick reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 53/47. The enantiomer excesses of anti-(2S, 3S)- and syn-(2S, 3R)-hydroxy esters were 89 and > 99ee% respectively. C. vulgaris and C. regularis afforded predominantly the syn-isomer, contrary to C. pyrenoidosa. The differences in the activity of reducing ethyl 2-methyl 3-oxobutanoate were observed among three strains of Chlorella. Addition of 2% metal salts slightly increased the chemical yield of the hydroxy ester.
authors.affiliation: Research Institute for Advanced Science and Technology, Osaka Prefecture University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuramoto
authors.forename: K
authors.initials: K
authors.lastname: Iwamoto
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.forename: M
authors.initials: M
authors.lastname: Kirihata
authors.forename: F
authors.initials: F
authors.lastname: Yoshizako
mesh_terms: D002087:Butyrates / Q000737:chemistry*; D002708:Chlorella / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D002087:Butyrates; C119270:ethyl 2-methyl-3-oxobutanoate