The effect of tulobuterol tape on histamine-induced bronchoconstriction in conscious guinea pigs: long duration of action.
The objective of the present study was to determine the action duration of tulobuterol tape within a 24-hr period in conscious guinea pigs. The bronchoconstriction induced by histamine-inhalation was significantly inhibited by tulobuterol tape in comparison with its placebo tape 8 and 12 hr after binding, and the inhibitory rate was 50+/-11% and 35+/-13%, respectively. Twenty-four hours after binding, the inhibitory effect of tulobuterol tape gradually diminished, but the inhibitory rate was maintained at 30+/-14%. These results suggest that tulobuterol tape has a long lasting bronchodilatory action.
Musoh
K
K
Research and Development Division, Hokuriku Seiyaku Co., Ltd., Katsuyama, Fukui, Japan.
Kawamura
K
K
Miyake
I
I
Shimada
S
S
Ohashi
T
T
Iwanaga
Y
Y
Morikawa
K
K
Kato
H
H
D000279:Administration, Cutaneous; D000403:Airway Resistance / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D003243:Consciousness; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008176:Lung Volume Measurements; D008297:Male; D013726:Terbutaline / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D001993:Bronchodilator Agents; C010809:tulobuterol; D006632:Histamine; D013726:Terbutaline