Increased plasma apolipoprotein B-containing lipoproteins associated with increased urinary albumin within the microalbuminuria range in type 2 diabetes.
BACKGROUND
While increased plasma concentrations of apolipoprotein B-containing lipoproteins are a feature of diabetic nephropathy associated with nephrotic range proteinuria, the relationship of plasma lipoproteins to increasing urine albumin concentration within the microalbuminuria range is less well-studied.


METHODS
We, therefore, examined the relationship between urine albumin excretion in the 0 to 100 mg/L range and plasma lipoproteins in 56 Oji-Cree with type 2 diabetes.


RESULTS
We found a significant direct relationship between the urinary albumin concentration within this low range and the plasma concentrations of total and low density lipoprotein cholesterol and apolipoprotein B (p = 0.015, 0.0032, and 0.0019, respectively).


CONCLUSIONS
These results suggest that the well-known relationship between gross proteinuria and hyperlipidemia may extend into the microalbuminuric range in subjects with type 2 diabetes.
Hegele
R A
RA
Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, London, Ontario, Canada. robert.hegele@rri.on.ca
Harris
S B
SB
Zinman
B
B
Hanley
A J
AJ
Connelly
P W
PW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000097:blood* / Q000150:complications; D001055:Apolipoproteins B / Q000097:blood*; D044466:Asian People; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007198:Indians, North American; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009864:Ontario; D012016:Reference Values; D012044:Regression Analysis
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D008074:Lipoproteins