In vitro susceptibilities of clinical yeast isolates to the new antifungal eberconazole compared with their susceptibilities to clotrimazole and ketoconazole.
The antifungal activity of eberconazole, a new imidazole derivative, against 124 clinical isolates of Candida comprising eight different species and to 34 isolates of Cryptococcus neoformans was compared to those of clotrimazole and ketoconazole. MICs of eberconazole, determined by the National Committee for Clinical Laboratory Standards standardized microbroth method, were equal to or lower than those of other azoles, especially for Candida krusei and Candida glabrata, which are usually resistant to triazoles.
Torres-Rodríguez
J M
JM
Experimental and Clinical Mycology Research Group (GREMEC), IMIM, Autonomous University of Barcelona, Barcelona, Spain. jmtorres@imim.es
Mendez
R
R
López-Jodra
O
O
Morera
Y
Y
Espasa
M
M
Jimenez
T
T
Lagunas
C
C
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D003022:Clotrimazole / Q000494:pharmacology*; D003454:Cryptococcus / Q000187:drug effects*; D003508:Cycloheptanes / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D003508:Cycloheptanes; D007093:Imidazoles; D003022:Clotrimazole; D007654:Ketoconazole; C118963:eberconazole