title: Effect of different microstructures of e-PTFE membranes on bone regeneration and soft tissue response: a histologic study in canine mandible.
abstract: The purpose of the present study was to compare the effect of 3 types of titanium reinforced e-PTFE membranes (GTRM #1, #2, and #3) on bone regeneration and tissue integration. GTRM #1 was a standard titanium reinforced membrane, GTRM #2 was a prototype characterized by a more open total surface microstructure and GTRM #3 was a prototype characterized by two extremely porous external layers separated by a totally occlusive internal layer. The membranes were used to cover saddle type ridge defects surgically created in the mandible of 6 dogs. After a healing period of 6 months, all the membrane protected sites demonstrated almost complete osseous healing of the defects. GTRM #3 specimens showed the most favourable biologic response, in fact they were characterized by a larger surface of contact between the membrane and the regenerated bone, but from a clinical point of view GTRM #3 material was too difficult to remove. The results of this study suggest that an extremely open porous microstructure, in combination with a totally occlusive barrier, may provide significant improvements in regenerative outcomes. However, these design characteristics may be applied only to resorbable devices, which do not require removal.
authors.affiliation: School of Dentistry, University of Milan, Department of Dentistry, San Raffaele Hospital, Italy. simion@askesis.it
authors.forename: M
authors.initials: M
authors.lastname: Simion
authors.forename: C
authors.initials: C
authors.lastname: Dahlin
authors.forename: K
authors.initials: K
authors.lastname: Blair
authors.forename: R K
authors.initials: RK
authors.lastname: Schenk
mesh_terms: D000539:Alveolar Process / Q000502:physiology; D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal; D008567:Membranes, Artificial; D010519:Periodontium / Q000502:physiology; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D016062:Porosity; D014025:Titanium; D014945:Wound Healing
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D014025:Titanium