title: [Value of sonography in prolonged neonatal jaundice. Findings in 13 cases].
abstract: BACKGROUND
  Different conditions are associated with a prolonged cholestatic jaundice in the neonatal period: viral hepatitis, biliary atresia and choledocal cyst are the most frequent causes. Laboratory findings are necessary, although they do not permit an etiologic diagnosis in all cases. Serial ultrasonographic study could be proposed for the evaluation of biliary excretion before and after feeding, in order to differentiate between these three conditions.
  
  
  METHODS
  Between February 1993 and January 1997, 13 newborns (seven girls and six boys) aged from 30 to 186 days, presented with jaundice and conjugated hyperbilirubinemia. They were evaluated by laboratory tests; serial ultrasonographic examinations were performed after 4 hours fasting then 1 and 2 hours after meal.
  
  
  RESULTS
  The gallbladder (GB) was visualized in nine patients. In five of these patients, it contracted after feeding suggesting the diagnosis of neonatal hepatitis, that was confirmed by the clinical evolution. In three patients, the GB did not change in size and the diagnosis of biliary atresia was surgically proven. In one patient, a choledocal cyst was visualized and confirmed by surgery. The GB was not identified after 4 hours of fasting in four patients; biliary atresia was suspected and confirmed by surgery.
  
  
  CONCLUSIONS
  Serial ultrasound of the GB is an easy and non-invasive method. It was useful in identifying those conditions requiring surgery in eight patients. We recommend its use as the initial method in the evaluation of neonatal jaundice before the other invasive methods.
authors.affiliation: Service de radiologie, Hôtel-Dieu de France, Beyrouth, Liban.
authors.forename: S
authors.initials: S
authors.lastname: Haddad-Zebouni
authors.forename: R
authors.initials: R
authors.lastname: Hindy
authors.forename: S
authors.initials: S
authors.lastname: Rahi
authors.forename: S
authors.initials: S
authors.lastname: Slaba
authors.forename: N
authors.initials: N
authors.lastname: Aoun
authors.forename: S
authors.initials: S
authors.lastname: Abi Ghanem
authors.forename: C
authors.initials: C
authors.lastname: Akatcherian
authors.forename: N
authors.initials: N
authors.lastname: Atallah
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging*; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D014463:Ultrasonography; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D001663:Bilirubin