Immunotolerant functions of HLA-G.
HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the fetal-maternal interface, where it plays a role in materno-fetal tolerance. In contrast to classical HLA-A, -B and -C class I molecules, HLA-G is characterized by (i) a tissue-restricted distribution, (ii) a limited polymorphism and (iii) a transcription of spliced messenger RNAs encoding for at least four membrane-bound and two soluble HLA-G isoforms. Extensive studies over the past few years have identified HLA-G as a molecule involved in immune tolerance. In this review, attempts were made to summarize the current state of knowledge of the effects of HLA-G on both natural killer and T cell functions and their implications in materno-fetal tolerance and tumor immunosurveillance.
Carosella
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ED
Service de Recherches en Hémato-Immunologie, Hôpital Saint-Louis, Institut d'Hématologie, Paris, France. carosella@dsvidf.cea.fr
Dausset
J
J
Rouas-Freiss
N
N
D003602:Cytotoxicity, Immunologic; D005260:Female; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology*; D007157:Immunologic Surveillance / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology; D009842:Oligopeptides / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology*; D000097625:HLA-E Antigens
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D009842:Oligopeptides; D000097625:HLA-E Antigens