Costimulatory molecules B7-1 and B7-2 on CSF cells in multiple sclerosis and optic neuritis.
The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) monocytes and B-lymphocytes from patients with MS, optic neuritis (ON) and other inflammatory central nervous system (CNS) diseases. In patients with ON but not MS, increased expression of B7-2 was detected as compared to non-inflammatory controls. The expression of B7-1 in MS and ON patients correlates with disease duration but not with relapses in patients with MS indicating a role in early disease but not as a reliable marker of disease activity at later stages of MS.
Windhagen
A
A
Department of Neurology, Medical School Hannover, Germany. windhagen.anja@mh-hannover.de
Maniak
S
S
Gebert
A
A
Ferger
I
I
Heidenreich
F
F
D015703:Antigens, CD / Q000032:analysis* / Q000276:immunology; D001402:B-Lymphocytes / Q000737:chemistry / Q000276:immunology; D018122:B7-1 Antigen / Q000032:analysis* / Q000276:immunology; D051940:B7-2 Antigen; D002555:Cerebrospinal Fluid / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000276:immunology; D018613:Microscopy, Confocal; D009000:Monocytes / Q000737:chemistry / Q000276:immunology; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000276:immunology*
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D008562:Membrane Glycoproteins