title: [Analysis of intermittent blood flow in experimental tumor using a transparent chamber].
abstract: Using a transparent chamber under a microscopic recording system equipped with a CCD camera, we measured real-time fluctuations of microvessel blood flow in an experimental murine tumor. Seven microvessels of the tumor showed 3-4 fluctuations in blood flow (intermittent blood flow) during the observation period (2 hours). Within the 120 min. monitoring period, we obtained approximately a maximum 52.5% of decreased blood flow. The duration of change in blood flow ranged from 15-45 min. Similar temporal fluctuations were seen in experimental animal tumors. Our data clearly demonstrated that fluctuations in blood flow (intermittent blood flow) in tumors are a common feature.
authors.affiliation: Dept. of Radiology, Kansai Medical University.
authors.forename: R
authors.initials: R
authors.lastname: Nasu
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Akai
authors.forename: M
authors.initials: M
authors.lastname: Uda
authors.forename: K
authors.initials: K
authors.lastname: Akagi
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D015687:Cell Hypoxia; D005260:Female; D008833:Microcirculation / Q000502:physiology; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344; D012039:Regional Blood Flow / Q000502:physiology