Prospective study of the clinical and laboratory parameters of patients in whom ovarian hyperstimulation syndrome developed during controlled ovarian hyperstimulation for in vitro fertilization.
OBJECTIVE
To compare patient characteristics and clinical and laboratory parameters in patients in whom ovarian hyperstimulation syndrome (OHSS) develops with those in whom it does not develop.


METHODS
Prospective cohort study.


METHODS
Reproductive medicine unit at a university medical center.


METHODS
All patients undergoing IVF (n = 428) who received controlled ovarian hyperstimulation during a 6-month period.


METHODS
Prospective data collection.


METHODS
Patient characteristics (age, body mass index, medical history, smoking habits) and clinical and laboratory data obtained during controlled ovarian hyperstimulation were evaluated in patients who had severe OHSS, any degree of OHSS, or a significant risk of OHSS and compared with the remaining populations.


RESULTS
Severe OHSS developed in 18 patients (4.2%) and mild or moderate OHSS developed in 7.3%. As a group, all the patients with OHSS were significantly younger, received lower doses of gonadotropins, had ovaries containing a higher number of total and large follicles, had a higher number of retrieved oocytes, and had a higher pregnancy rate than the patients without OHSS. The patients with severe OHSS also had an increased prevalence of allergy (56% versus 21%) and were more likely to ultimately give birth.


CONCLUSIONS
The observed differences may be useful in elucidating the pathophysiology of OHSS and identifying patients who are at increased risk for OHSS.
Enskog
A
A
Department of Anesthesia and Intensive Care, Göteborg University, Sweden.
Henriksson
M
M
Unander
M
M
Nilsson
L
L
Brännström
M
M
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000209:etiology*; D010062:Ovulation Induction / Q000009:adverse effects*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies
D012739:Gonadal Steroid Hormones