title: Acromegaly: report of two patients with an unusual presentation.
abstract: The presenting features of functionally active pituitary tumours depend on the specific hormone which is overproduced. Growth hormone (GH) producing tumours usually present with the clinical manifestations of acromegaly due to excessive GH secretion or symptoms resulting from mass effects of the enlarging tumour. The changes in physical features and the increase in tumour size are usually insidiously slow and therefore, recognition of the disease is delayed. In this report two patients with acromegaly are described with an atypical presentation due to acute onset of symptoms. The first patient presented with central diabetes insipidus. The diagnosis acromegaly was made on physical examination. The second patient presented with a generalized seizure during sleep. On CT-scanning a large tumour protruding into the left temporal lobe connected to the pituitary gland was seen. Immunohistochemistry of the tumour after partial transcranial resection confirmed the clinical diagnosis of acromegaly. At a later stage transsphenoidal resection of the pituitary tumour was performed with full recovery and without loss of pituitary function.
authors.affiliation: University Hospital, Department of Endocrinology, Utrecht, The Netherlands. mcc.vigo@wxs.nl
authors.forename: M
authors.initials: M
authors.lastname: Castro Cabezas
authors.forename: P M
authors.initials: PM
authors.lastname: Zelissen
authors.forename: G H
authors.initials: GH
authors.lastname: Jansen
authors.forename: A P
authors.initials: AP
authors.lastname: Van Gils
authors.forename: H P
authors.initials: HP
authors.lastname: Koppeschaar
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis; D003919:Diabetes Insipidus / Q000209:etiology*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis; D012640:Seizures / Q000209:etiology*
chemical_list: D007334:Insulin-Like Growth Factor I