title: Thymoma associated with myasthenia gravis and minimal lesion nephrotic syndrome.
abstract: A nephrotic syndrome has been observed rarely in association with thymoma. In most of the reported cases, it occurs when the thymoma is in remission; histological examination generally shows minimal change disease. We report a case of a 43-year-old man presenting with minimal lesion nephrotic syndrome at the time of the diagnosis of thymoma and myasthenia gravis, which persists despite remission of the thymoma. The role of a disorder of T-cell function and of circulating cytokines is discussed.
authors.affiliation: Service de Néphrologie et d'Hémodialyse, Hôpital Saint-André, Bordeaux Cedex, France. christian.combe@nephro.u-bordeaux2.fr
authors.forename: C
authors.initials: C
authors.lastname: Lasseur
authors.forename: C
authors.initials: C
authors.lastname: Combe
authors.forename: C
authors.initials: C
authors.lastname: Deminière
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
authors.forename: M
authors.initials: M
authors.lastname: Aparicio
mesh_terms: D000328:Adult; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000150:complications*; D009402:Nephrosis, Lipoid / Q000209:etiology* / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology; D013945:Thymoma / Q000150:complications* / Q000628:therapy; D013953:Thymus Neoplasms / Q000150:complications* / Q000628:therapy
chemical_list: D016207:Cytokines