Role of different lymphocyte subpopulations in the formation of non-specific immunoglobulins induced by antigen injection.
The formation of antibody and non-specific immunoglobulin under the influence of T-dependent (TD) and type 2 T-independent (TI-2) antigens in mice of two congenic strains CBA (Lyb5-, Lyb5+) and CBA/N (Lyb5-) was studied. TD antigens induced in mice of both strains not only the appearance of antibody-forming cells (AFC), but also a great increase in the number of cells producing non-specific immunoglobulins (nIFC). TI-2 antigens induced the AFC and antigen-dependent nIFC formation in CBA mice only. It is concluded that during immune response to TI-2 antigens not only the AFC appearance but the increase in nIFC formation (polyclonal activation) is due mainly to the mature Lyb5+ B cells.
Chernyshova
I N
IN
Institute for Viral Preparations of Russian Academy of Medical Sciences, Moscow.
Borisova
T K
TK
Emelyanzeva
J A
JA
Sidorova
E V
EV
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D000950:Antigens, Ly / Q000235:genetics / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D007267:Injections; D016131:Lymphocyte Subsets / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D011205:Povidone; D012756:Sheep
D000941:Antigens; D000950:Antigens, Ly; D000956:Antigens, Viral; C031007:DNP-Ficoll; D007136:Immunoglobulins; D005362:Ficoll; D011205:Povidone