title: [Premature rupture of membranes: maternal and fetal outcome in the absence of antibiotic prophylaxis].
abstract: Antibiotic prophylaxis in the management of Premature Rupture of foetal Membranes (PROM) before term still remains controversial. 110 pregnant women with PROM were assigned to either group A (no treatment) or group B (treatment group). The rates of premature deliveries were similar in the two groups, 71% versus 77% (p = 0.56). Additionally, low birth weight, Apgar score, foetal distress, neonatal icterus and foetal sepsis were all observed in similar proportions in both groups. 6.5% of the subjects in group A developed endometritis as against 5.7% in group B (p = 0.69). Perinatal mortality rates were high (33.3% and 50%, in group A and B, respectively), but not statistically different in the two groups (p = 0.13). Prophylactic antibiotics do not seem to influence maternal and foetal outcome in patients who present with PROM in this environment.
authors.affiliation: WHO/HRP/Faculté de Médecine et des Sciences Biomédicales de l'Université de Yaoundé I, Cameroun.
authors.forename: R E
authors.initials: RE
authors.lastname: Mbu
authors.forename: R
authors.initials: R
authors.lastname: Tchio
authors.forename: R J
authors.initials: RJ
authors.lastname: Leke
authors.forename: N E
authors.initials: NE
authors.lastname: Tamba
authors.forename: N
authors.initials: N
authors.lastname: Njoh
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D005316:Fetal Distress / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018805:Sepsis / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents