Vascular permeability factor expression in cerebellar hemangioblastomas: correlation with tumor-associated cysts.
The presence of vascular endothelial growth/permeability factor (VEG/PF) has been studied in histological specimens from a series of 16 cerebellar hemangioblastomas. In this series, the tumors were classified as presenting a macroscopic solid pattern (4 cases), a mainly solid pattern with macroscopic cysts (4 cases) or a mainly cystic pattern (8 cases). Solid tumors showed a low degree (75% of cases) or moderate degree (25% of cases) of VEG/PF positivity. The mainly solid tumors containing macroscopic cysts showed a moderate degree (50% of cases) or high degree (50% of cases) of VEG/PF positivity. Nevertheless, mainly cystic hemangioblastomas showed a high degree (87.5% of cases) or moderate degree (12.5% of cases) of VEG/PF positivity. These findings suggest that the predominance of a cystic or solid macroscopic appearance of cerebellar hemangioblastomas may be influenced by the degree of VEG/PF expression within the tumor tissue.
Vaquero
J
J
Laboratory of Experimental Neuro-Oncology, Mapfre-Medicine Foundation, Madrid, Spain.
Zurita
M
M
Oya
S
S
Coca
S
S
Salas
C
C
D002528:Cerebellar Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003560:Cysts / Q000209:etiology / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000096:biosynthesis*; D018325:Hemangioblastoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000096:biosynthesis*; D008279:Magnetic Resonance Imaging; D016612:Paraffin Embedding; D014057:Tomography, X-Ray Computed; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors