[Effect of antibiotics and antibody on phagocytic bactericidal activity of polymorphonuclear neutrophils of Bordetella pertussis].
The phagocytic bactericidal activity of the polymononucler neutrophils (PMNs) that were collected from healthy volunteer with and without antibody against Bordetella pertussis was investigated. Furthermore, these activity against B. pertussis under observing penicillins or macrolides antibiotics was investigated. Although no efficacy to B. pertussis strain by the PMNs in serum without antibody, but the viable cells of B. pertussis decreased to 1/1,000 1 hr after incubation and was not detected after 4 hrs. In particular, the viable cells of B. pertussis by the PMNs in serum with antibody was markedly reduced when azithromycin was present. These results suggests that the synergistic action of macrolide antibiotics and antibody-mediated phagocytic bactericidal activity on B. pertussis may have clinical relevance.
Muraoka
H
H
Chemotherapy Division, Mitsubishi-Kagaku Bio-Clinical Laboratories.
Aoyama
T
T
Saika
T
T
Sato
Y
Y
Kobayashi
I
I
Akita
H
H
Iwata
S
S
Sato
Y
Y
Sunakawa
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000907:Antibodies, Bacterial / Q000187:drug effects* / Q000276:immunology*; D001886:Bordetella pertussis / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D018942:Macrolides; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010406:Penicillins / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology*
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D018942:Macrolides; D010406:Penicillins