title: Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease.
abstract: The authors report high intrathecal release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-alpha and IL-1beta was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.
authors.affiliation: Department of Neurology, Guy's Hospital, London, England. m.sharief@umds.ac.uk
authors.forename: M K
authors.initials: MK
authors.lastname: Sharief
authors.forename: A
authors.initials: A
authors.lastname: Green
authors.forename: J P
authors.initials: JP
authors.lastname: Dick
authors.forename: J
authors.initials: J
authors.lastname: Gawler
authors.forename: E J
authors.initials: EJ
authors.lastname: Thompson
mesh_terms: D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000134:cerebrospinal fluid* / Q000276:immunology; D007375:Interleukin-1 / Q000134:cerebrospinal fluid; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha