Transcription factor IIH: a key player in the cellular response to DNA damage.
TFIIH (transcription factor IIH) is a multiprotein complex consisting of nine subunits initially characterized as a basal transcription factor required for initiation of protein-coding RNA synthesis. TFIIH was the first transcription factor shown to harbor several enzymatic activities, likely indicative of functional complexity. This intricacy was further emphasized with the cloning of the genes encoding the different subunits which disclosed direct connections between transcription, DNA repair and cell cycle regulation. In this review, we emphasize those functions of TFIIH involved in DNA repair, as well as their relationship to TFIIH's roles in transcription, cell cycle control and apoptosis. These connections may prove to be essential for the cellular response to DNA damage.
Frit
P
P
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Université Louis-Pasteur, Strasbourg, Illkirch, France.
Bergmann
E
E
Egly
J M
JM
D002453:Cell Cycle; D004249:DNA Damage; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII
D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH