The effects of mouth rinses and dentifrice-containing magnesium monoperoxyphthalate (mmpp) on oral microflora, plaque reduction, and mucosa.
The effects of a magnesium monoperoxyphthalate (MMPP) mouth-rinse, with or without sodium lauryl sulphate (SLS), and an MMPP dentifrice, on salivary counts of bacterial flora and yeasts, and on supragingival plaque scores were investigated in 131 healthy oral candida carriers over a 9 week double blind study. There were no changes in the salivary counts of bacteria studied (anaerobes, streptococci, fusobacteria, Actinomyces, Viellonella) in the test or placebo groups. A significant increase in salivary candida counts was seen in subjects using an MMPP rinse and dentifrice compared with placebo subjects and this phenomenon was not influenced by the presence of SLS. A significant reduction in plaque was seen in subjects using an MMPP rinse and dentifrice compared with placebo subjects. Frank candidosis was observed in only 2 subjects (1 in the placebo rinse group and 1 in the MMPP dentifrice group) but erythematous lesions, with subjective reports of soreness, dryness or burning sensation, were recorded and observed more frequently in the experimental groups than in the placebos, especially in those also using SLS. The substantial plaque reduction achieved with MMPP in the absence of tooth staining but with the increase in salivary Candida counts suggests that further studies of MMPP are warranted.
Scully
C
C
Department of Oral Medicine, Eastman Dental Institute for Oral Healthcare Sciences and International Centres for Excellence in Dentistry, University of London, UK. Cscully@eastman.ucl.ac.uk
El-Kabir
M
M
Greenman
J
J
Porter
S R
SR
Mutlu
S
S
Barton
I
I
Adair
R
R
D000190:Actinomyces / Q000187:drug effects; D000328:Adult; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005673:Fusobacterium / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D009059:Mouth Diseases / Q000139:chemically induced; D009061:Mouth Mucosa / Q000187:drug effects*; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D010795:Phthalic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D012463:Saliva / Q000382:microbiology; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013291:Streptococcus / Q000187:drug effects; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014678:Veillonella / Q000187:drug effects; D014987:Xerostomia / Q000139:chemically induced
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003802:Dentifrices; D009067:Mouthwashes; D010795:Phthalic Acids; D010919:Placebos; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; C044731:magnesium monoperoxyphthalate