title: Two absorption furosemide prodrugs.
abstract: The structures of two absorption furosemide prodrugs, hexanoyloxymethyl 4-chloro-N-furfuryl-5-sulfamoyl-anthranilate (C19H23CIN2O7S), (I), and benzoyloxymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate (C20H17CIN2O7S), (II), are described in this paper and compared with furosemide and four other prodrugs. The molecular conformations of both compounds are similar to those of the other prodrugs; the packing and the crystal system are the primary differences. Compound (I) crystallizes in the trigonal space group R3 and compound (II) in the monoclinic space group P2(1)/n. The packing of both structures is stabilized by a three-dimensional hydrogen-bond network.
authors.affiliation: Laboratorio de Cristalografía y Química del Estado Sólido, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
authors.forename: A W
authors.initials: AW
authors.lastname: Mombrú
authors.forename: R A
authors.initials: RA
authors.lastname: Mariezcurrena
authors.forename: L
authors.initials: L
authors.lastname: Suescun
authors.forename: H
authors.initials: H
authors.lastname: Pardo
authors.forename: E
authors.initials: E
authors.lastname: Manta
authors.forename: C
authors.initials: C
authors.lastname: Prandi
mesh_terms: D018360:Crystallography, X-Ray; D005665:Furosemide / Q000493:pharmacokinetics*; D006860:Hydrogen Bonding; D007408:Intestinal Absorption; D008958:Models, Molecular; D011355:Prodrugs / Q000493:pharmacokinetics*
chemical_list: D011355:Prodrugs; D005665:Furosemide