[New approaches to designing metabolic antihypoxants].
The paper outlines a concept of recovering the energy-synthesizing dysfunction of the respiratory chain at different stages of hypoxia: at the early stage which shows the disturbances of mitochondrial enzymatic complex I function, their correction is made by using the redox agents shunting the transport of electrons at NADH-CoQ, as well as by means of different succinate-oxidase oxidation activators. At the later stages of hypoxia demonstrating the disturbances of electron transport function at the cytochrome site, their correction is effected by applying CoQ and cytochrome C. The mechanisms of the antihypoxic action produced by antioxidative agents are described. The prospects of searching novel antihypoxants are defined.
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D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015195:Drug Design; D004579:Electron Transport / Q000187:drug effects; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects
D000975:Antioxidants