Impaired beta-adrenoceptor mediated venodilation in patients with diabetes mellitus.
OBJECTIVE
We investigated whether venoconstriction by alpha-adrenoceptor stimulation, and venodilation by beta-adrenoceptor stimulation and nitroglycerin are altered in patients with diabetes mellitus (DM).


METHODS
Eight male patients with non insulin-dependent DM and eight age-matched control subjects were included. The patients had neither hypertension nor hyperlipidaemia. Noradrenaline (1 to 512 ng min-1 ), isoprenaline (1 to 256 ng min-1 ) and nitroglycerin (0.5 to 128 ng min-1 ) were infused into a dorsal hand vein and its diameter was measured using a linear variable differential transformer.


RESULTS
The venoconstricting response to noradrenaline and the venodilating response to nitroglycerin in DM patients were similar to those in control subjects, while the venodilation by isoprenaline was significantly (P<0.05) smaller in DM patients than in control subjects at the dose of 32 ng min-1 or more [32 ng min-1: 11.5% vs 29.8% (DM vs control subjects), 64 ng min-1: 19.0% vs 40.1%, 128 ng min-1: 25.2% vs 49.0%, 256 ng min-1: 34.3% vs 56.7%].


CONCLUSIONS
These data suggested that venoconstriction by alpha-adrenoceptor stimulation and venodilation by nitroglycerin are not altered, whereas venodilation by beta-adrenoceptor stimulation might be impaired in patients with DM.
Harada
K
K
Department of Clinical Pharmacology, Jichi Medical School, Minamikawachi, Tochigi 329-0498, Japan.
Ohmori
M
M
Kitoh
Y
Y
Sugimoto
K
K
Fujimura
A
A
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005905:Glyburide / Q000494:pharmacology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D005996:Nitroglycerin; D007545:Isoproterenol; D005905:Glyburide; D009638:Norepinephrine