[The emergence of multiple antimicrobial resistance in Vibrio cholerae isolated from gastroenteritis patients in Ceará, Brazil].
Of 7058 Vibrio cholerae strains recovered from patients suspected of cholera in the State of Ceará between December 1991 and September 1993, two were resistant to antimicrobials (Ampicillin, erythromycin, trimethoprim-sulfamethoxazole, tetracycline) and to vibriostatic agent O/129 (2,4-diamino-6,7-diisopropylpteridine). From the bacteriological standpoint, one strain was identified as V. cholerae serogroup O:1, biotype El Tor, serovar Inaba, and another as V. cholerae serogroup O:22, biochemically classified as Heiberg type II. It was shown that only in the serogroup O:1 strain, multiple resistance was encoded by a plasmid transferrable by conjugation to Escherichia coli K12 and a sensitive strains of V. cholerae O1 and non-O1, with at a frequency between 8 x 10(-2) and 5 x 10(-6). The plasmid, with a molecular weight of 147 Kb, encoded both multiple resistance to antimicrobials and the vibriostatic compound (O/129), compatible with descriptions reported in other parts of world.
Hofer
E
E
Laboratório de Zoonoses Bacterianas, Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brasil.
Quintaes
B R
BR
dos Reis
E M
EM
Rodrigues
D dos P
Ddos P
Seki
L M
LM
Feitosa
I S
IS
Ribeiro
L H
LH
Ferreira
M R
MR
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D001938:Brazil; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005759:Gastroenteritis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D012703:Serotyping; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents