title: B-cell (CD79a+) lymphoma affecting the tarsal joint synovia in a sheep.
abstract: A lymphoma affecting the synovia was identified in both tarsal joints of an aged sheep. With a panel of cross-reactive antibodies specific for lambda and kappa immunoglobulin light chain, MHC class II, CD3, CD79a and the Ki-67 antigen, the neoplasm was classified as a B-cell lymphoma with uniform expression of surface membrane CD79a. This would seem to be the first report of a lymphoma affecting the synovia in a domestic animal, and the first use of the CD79a reagent on ovine tissue.
authors.affiliation: Department of Pathology and Microbiology, University of Bristol Veterinary School, Langford, BS40 7DU, UK.
authors.forename: G R
authors.initials: GR
authors.lastname: Pearson
authors.forename: M J
authors.initials: MJ
authors.lastname: Day
authors.forename: D
authors.initials: D
authors.lastname: Main
authors.forename: J
authors.initials: J
authors.lastname: Pawade
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis*; D017252:CD3 Complex / Q000276:immunology; D051925:CD79 Antigens; D003429:Cross Reactions; D017809:Fatal Outcome; D007147:Immunoglobulin Light Chains / Q000276:immunology; D019394:Ki-67 Antigen / Q000276:immunology; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000662:veterinary*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology*; D013640:Tarsal Joints / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; D007147:Immunoglobulin Light Chains; D019394:Ki-67 Antigen; D011947:Receptors, Antigen, B-Cell