title: beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children.
abstract: Oral Fusobacterium nucleatum populations from 20 young, healthy children were examined for beta-lactamase production. Ten children (50%) harbored, altogether, 25 beta-lactamase-positive F. nucleatum isolates that were identified as F. nucleatum subsp. polymorphum, F. nucleatum subsp. nucleatum, and F. nucleatum subsp. vincentii (J. L. Dzink, M. T. Sheenan, and S. S. Socransky, Int. J. Syst. Bacteriol. 40:74-78, 1990). In vitro susceptibility of these beta-lactamase-producing and 26 non-beta-lactamase-producing F. nucleatum isolates was tested with penicillin G, amoxicillin-clavulanic acid, tetracycline hydrochloride, metronidazole, trovafloxacin, and azithromycin. Except for penicillin G, the antimicrobials exhibited good activity against all F. nucleatum isolates.
authors.affiliation: Anaerobe Reference Laboratory, National Public Health Institute, Helsinki, Finland. Eija.Kononen@ktl.fi
authors.forename: E
authors.initials: E
authors.lastname: Könönen
authors.forename: A
authors.initials: A
authors.lastname: Kanervo
authors.forename: K
authors.initials: K
authors.lastname: Salminen
authors.forename: H
authors.initials: H
authors.lastname: Jousimies-Somer
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D002675:Child, Preschool; D005260:Female; D024841:Fluoroquinolones; D016967:Fusobacterium nucleatum / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D008795:Metronidazole; D019980:Amoxicillin-Potassium Clavulanate Combination; D017963:Azithromycin; C080163:trovafloxacin; D001618:beta-Lactamases; D013752:Tetracycline; D010400:Penicillin G