title: T-cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics.
abstract: We have previously presented evidence of a highly organized and compartmentalized structure of the small intestinal lamina propria of the pig. In this study, we conducted a detailed analysis of the T-cell populations found at this site, and compared these T cells with cell populations found in other tissue sites and the periphery. We showed that the CD4+ and CD8+ T-cell populations found in the pig gut are of memory phenotype, defined by CD45 isoform expression, but show few signs of recent activation. They show a high degree of phenotypic and therefore presumably functional homogeneity. Both CD4- and CD8-positive cells show strong parallels in the patterns of surface molecule expression, suggesting similar pressures on differentiation. The unique combination of surface molecules found on lamina propria T cells is found only infrequently on cells in other lymphoid sites.
authors.affiliation: Division of Molecular and Cellular Biology, University of Bristol, Langford, North Somerset, UK.
authors.forename: K
authors.initials: K
authors.lastname: Haverson
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: C R
authors.initials: CR
authors.lastname: Stokes
mesh_terms: D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D018821:CD18 Antigens; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005434:Flow Cytometry; D018960:Hyaluronan Receptors; D007156:Immunologic Memory; D019012:Integrin beta1; D007421:Intestine, Small / Q000276:immunology*; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation / Q000276:immunology*; D013552:Swine / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D018821:CD18 Antigens; D017252:CD3 Complex; D018960:Hyaluronan Receptors; D019012:Integrin beta1; D017493:Leukocyte Common Antigens