title: A semi-automated method to quantify left ventricular diastolic inflow propagation by magnetic resonance phase velocity mapping.
abstract: A new method of analysis was used for clinical magnetic resonance phase velocity mapping (PVM) to quantify propagation speed (PS) of early diastolic left ventricular (LV) inflow. A group of older volunteers (OV; n = 21, age 58+/-11 years) and a group of aortic stenosis patients (AS; n = 21, age 69+/-8 years) were studied. PVM was used to measure diastolic inflow in the LV outflow tract plane. PS was quantified by a semi-automated method (Auto) and by an operator (Manual). The mean+/-SD PS was 0.71+/-0.21 (Auto) and 0.67+/-0.23 (Manual) m/sec in the OV group, versus 0.49+/-0.28 (Auto) and 0.43+/-0.18 m/sec (Manual) in the AS group. There were no differences in peak transmitral E-wave (P = 0.70) between OV and AS. However, there were differences in PS-Auto (P = 0.0079) and PS-Manual (P = 0.0007) between the two groups. PS is a promising index for identifying diastolic LV dysfunction in AS patients. The semi-automated technique is a practical approach for quantifying LV filling.
authors.affiliation: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta 30332-0363, USA.
authors.forename: S F
authors.initials: SF
authors.lastname: Milet
authors.forename: J L
authors.initials: JL
authors.lastname: Mayberry
authors.forename: H R
authors.initials: HR
authors.lastname: Ivarsen
authors.forename: O
authors.initials: O
authors.lastname: Eschen
authors.forename: K
authors.initials: K
authors.lastname: Houlind
authors.forename: E M
authors.initials: EM
authors.lastname: Pedersen
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D000328:Adult; D000368:Aged; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000503:physiopathology; D001783:Blood Flow Velocity; D003971:Diastole; D005260:Female; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D016277:Ventricular Function, Left