Aerosol recovery from large-volume reservoir delivery systems is highly dependent on the static properties of the reservoir.
In this study, the role of electrostatic fields on aerosol recovery from a system with a large collapsible reservoir (30 L) was investigated. In addition, the efficacy of the reservoir method for bronchial challenge procedures was assessed in vivo. Aerosol recovery was determined by measuring the fraction of aerosol (0.05% 99mTc-tagged human albumin solution) retrieved from the reservoir. Before aerosol recovery experiments, electrostatic fields in the reservoir were measured. Aerosol recovery varied significantly with wall thickness of the reservoir and presence of an antistatic coating (range 6.0-70.3%). A close inverse relationship was found between the mean electrostatic field in the reservoir and aerosol recovery. The nebulized provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second in asthmatics was found to be approximately half that of a standard method when compared with the reservoir system (mean ratio 2.24 (95% confidence interval, 1.60-3.12)). Recovery from an aerosol delivery system with a relatively large collapsible aerosol reservoir was highly dependent on the electrostatic field in the reservoir. In these systems the use of electrostatic field dissipative material for the reservoir is therefore recommended.
van der Veen
M J
MJ
Dept of Pulmonology, Academic Medical Centre, University of Amsterdam, The Netherlands.
van der Zee
J S
JS
D000280:Administration, Inhalation; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001249:Asthma / Q000188:drug therapy; D001985:Bronchial Provocation Tests; D018592:Cross-Over Studies; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D005260:Female; D006632:Histamine / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D016014:Linear Models; D008297:Male; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D055672:Static Electricity
D000336:Aerosols; D006632:Histamine