The utility of clinical and radiographic features in the diagnosis of cytomegalovirus central nervous system disease in AIDS patients.
BACKGROUND
Polymerase chain reaction (PCR) assays of cerebrospinal fluid (CSF) for cytomegalovirus (CMV) DNA have facilitated the diagnosis of CMV-associated central nervous system disease in AIDS patients. We attempt to correlate clinical and radiographic features that are associated with CMV PCR- positivity in CSF from AIDS patients with neurologic disease.


RESULTS
A retrospective case controlled comparison was made of CMV PCR-positive and PCR-negative patients.


RESULTS
CMV PCR-positive patients were significantly more likely to have nystagmus, prior CMV retinitis, and CSF protein levels.90 mg/dL. Of patients with 0, 1, and $2 of these features, 5.6%, 55.2%, and 88.9%, respectively, were PCR-positive. Ependymal enhancement was present by magnetic resonance imaging in 9 of 12 PCR-positive, and in 8 of 30 PCR-negative patients.


CONCLUSIONS
These clinical and radiographic features may serve as useful adjuncts toward the establishment of the diagnosis of CMV-associated neurologic disease in AIDS patients.
Burke
D G
DG
Departments of Medicine, Pathology and Radiology, University Hospitals of Cleveland, MetroHealth Medical Center, Cleveland, OH 44109-1998, USA.
Leonard
D G
DG
Imperiale
T F
TF
Valdez
H
H
Karaman
B
B
Shick
E
E
Kalayjian
R C
RC
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D000328:Adult; D016022:Case-Control Studies; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D017726:Cytomegalovirus Retinitis / Q000150:complications / Q000175:diagnosis; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D004805:Ependyma / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009187:Myelitis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000821:virology; D009759:Nystagmus, Pathologic / Q000175:diagnosis / Q000209:etiology; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D011843:Radiculopathy / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000821:virology; D011859:Radiography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method
D004279:DNA, Viral