title: Cross-linked hyaluronan (Hylan B gel): a new injectable remedy for treatment of vocal fold insufficiency--an animal study.
abstract: After injection of hylan B gel (Hylaform), the vocal folds of rabbits were studied by light microscopy at various time-points up to 12 months. Hylan B gel is a viscoelastic cross-linked and insoluble hyaluronan derivative which behaves as a soft gel. It is non-immunogenic, non-toxic and non-inflammatory and has already been used in plastic surgery for intradermal implantations. Macroscopic examination of the injected vocal folds revealed a bulging in six of the animals, but on microscopical examination the hylan B gel was encountered in all of them. Already after 1 month, and increasingly so up to 12 months, there was an ingrowth of new connective tissue, with collagen, fibroblasts and hyaluronan within the gel. No inflammatory reaction or any sign of a foreign body reaction was observed throughout the study. Hylaform may well become useful as an injection material for augmentation of vocal folds in the treatment of vocal fold insufficiency.
authors.affiliation: Department of Otorhinolaryngology, Central Hospital of Falun, Sweden. lars.d.hallen@ltdalarna.se
authors.forename: L
authors.initials: L
authors.lastname: Hallén
authors.forename: C
authors.initials: C
authors.lastname: Johansson
authors.forename: C
authors.initials: C
authors.lastname: Laurent
mesh_terms: D000818:Animals; D005782:Gels; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D007267:Injections; D019736:Prostheses and Implants; D011817:Rabbits; D014827:Vocal Cords
chemical_list: D005782:Gels; D006820:Hyaluronic Acid