title: [Clinicopathological features of advanced gastric cancer. Report on 400 operated cases].
abstract: In the present study the Authors report the clinical and pathological characteristics of highly advanced cases of gastric carcinoma. Of 1204 primary gastric cancer cases observed between 1977 and 1994 at the Second Department of Surgery, University of Siena, 400 cases treated by non-curative surgery were selected for this study: 174 explorative laparotomies, 76 by-pass and 150 resective operations, of which 98 relatively non-curative and 52 absolutely non-curative resections. The clinical and pathological features of these cases were compared with curative resection cases. Of several variables examined at univariate analysis, tumor site, macroscopic aspect, tumor size, depth in gastric wall and lymph nodal involvement significantly influenced the operative rate and the rate of non-curative operations (p < 0.001). With reference to non-curative cases, the diffusion pattern of neoplasm, besides the above mentioned variables, significantly affected the resectability rate: distant metastases, and particularly peritoneal spread, involved a lower resection rate if compared to cases with loco-regional diffusion (p < 0.001).
authors.affiliation: Istituto Policattedra di Scienze Chirurgiche, Università degli Studi di Siena.
authors.forename: A
authors.initials: A
authors.lastname: De Stefano
authors.forename: F
authors.initials: F
authors.lastname: Roviello
authors.forename: D
authors.initials: D
authors.lastname: Marrelli
authors.forename: G
authors.initials: G
authors.lastname: Fotia
authors.forename: E
authors.initials: E
authors.lastname: Pinto
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery