title: [The role of MHC class II genes in the etiopathogenesis of rheumatoid arthritis].
abstract: Rheumatoid arthritis (RA) is associated with HLA-DR4 and DR1 antigens. HLA-DRB1 gene sequences analysis demonstrated that only a limited set of alleles is positively associated with RA. Third hypervariable region sequences (70-74, 86) Q(R)R(K)RAA, G(V) are found in up to 95% of erosive RA. The presence of disease-associated allels may predict severe outcome of the disease. Therefore, their presence may allow us to start aggressive therapy in early stage of the disease.
authors.affiliation: Kliniki Reumatologii, IChW Akademia Medyczna im. Karola Marcinkowskiego w Poznaniu.
authors.forename: J K
authors.initials: JK
authors.lastname: Lacki
authors.forename: I
authors.initials: I
authors.lastname: Korczowska
authors.forename: S H
authors.initials: SH
authors.lastname: Mackiewicz
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D015798:HLA-DR1 Antigen / Q000235:genetics; D015804:HLA-DR4 Antigen / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics
chemical_list: D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains; D007135:Immunoglobulin Variable Region