title: Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.
abstract: We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol.
authors.affiliation: Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Freskos
authors.forename: B V
authors.initials: BV
authors.lastname: Mischke
authors.forename: G A
authors.initials: GA
authors.lastname: DeCrescenzo
authors.forename: R
authors.initials: R
authors.lastname: Heintz
authors.forename: D P
authors.initials: DP
authors.lastname: Getman
authors.forename: S C
authors.initials: SC
authors.lastname: Howard
authors.forename: N N
authors.initials: NN
authors.lastname: Kishore
authors.forename: J J
authors.initials: JJ
authors.lastname: McDonald
authors.forename: G E
authors.initials: GE
authors.lastname: Munie
authors.forename: S
authors.initials: S
authors.lastname: Rangwala
authors.forename: C A
authors.initials: CA
authors.lastname: Swearingen
authors.forename: C
authors.initials: C
authors.lastname: Voliva
authors.forename: D J
authors.initials: DJ
authors.lastname: Welsch
mesh_terms: D005109:Extracellular Matrix / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011480:Protease Inhibitors; D013438:Sulfhydryl Compounds; D008666:Metalloendopeptidases