A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation.
We report the case of a 32-year-old patient with ALL who developed autoimmune thrombocytopenia 2 months following allogeneic bone marrow transplantation. An IgM autoantibody against the platelet glycoprotein Ib/IX complex was observed. Treatment with high-dose steroids and intravenous immunoglobulin G failed to produce any benefit and the thrombocytopenia led to fatal gastrointestinal haemorrhage. The possible factors contributing to post-allograft thrombocytopenia and potential management strategies are discussed.
Kottaridis
P D
PD
Department of Haematology, University College London Hospitals, UK.
Rees
H
H
Smith
G
G
Garner
S F
SF
Perry
A R
AR
Peniket
A J
AJ
Goldstone
A H
AH
Mackinnon
S
S
Ouwehand
W H
WH
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology*; D014019:Tissue Donors
D001323:Autoantibodies; D007075:Immunoglobulin M; D019038:Platelet Glycoprotein GPIb-IX Complex