Elastin: molecular description and function.
Elastin, the protein responsible for the elastic properties of vertebrate tissues, has been thought to be solely restricted to that role. As a consequence, elastin was conventionally described as an amorphous polymer. Recent results in the biomedical, biochemical and biophysical fields have lead to the conclusion that the presence of elastin in the extracellular space has very complex implications involving many other molecules. The present review describes the current state of knowledge concerning elastin as an elastic macromolecule. First, the genetic, biological, biochemical and biophysical processes leading to a functional polymer are described. Second, the elastic function of elastin is discussed. The controversy on elastin structure and elasticity is discussed and a novel dynamic mechanism of elasticity proposed. Finally, pathologies where the elastin molecule is involved are considered. This updated description of functional elastin provides the required background for the understanding of its pathologies and defines clearly the properties a substance should possess to be qualified as a good elastic biomaterial.
Debelle
L
L
Department of Chemistry, University of Basilicata, Potenza, Italy.
Tamburro
A M
AM
D000818:Animals; D001024:Aortic Valve Stenosis / Q000503:physiopathology; D003483:Cutis Laxa / Q000503:physiopathology; D004547:Elastic Tissue / Q000473:pathology; D004549:Elastin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012871:Skin Diseases / Q000503:physiopathology; D013329:Structure-Activity Relationship; D018980:Williams Syndrome / Q000503:physiopathology
D004549:Elastin