title: Modular evolution of the integrase domain in the Ty3/Gypsy class of LTR retrotransposons.
abstract: A phylogenetic analysis of the Ty3/Gypsy group of retrotransposons identified a conserved domain (GPY/F) present in the integrases of several members of this group as well as of certain vertebrate retroviruses. The analysis suggested an evolutionary scheme for the acquisition and loss of the GPY/F domain as well as the acquisition of a chromodomain module in the integrase encoded by this group of elements that may direct targeting specificity in the host genome.
authors.affiliation: Department of Biology, University of Rochester, Rochester, New York 14627-0211, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Malik
authors.forename: T H
authors.initials: TH
authors.lastname: Eickbush
mesh_terms: D000595:Amino Acid Sequence; D019426:Integrases / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D018626:Retroelements; D020079:Terminal Repeat Sequences
chemical_list: D018626:Retroelements; D019426:Integrases