title: Liver disease as primary manifestation of multiple myeloma in a young man.
abstract: We report a 27-year-old man who presented with fatigue, moderate weight loss and progressive abdominal distension as primary manifestations of a light-chain multiple myeloma (MM). Liver scan showed an enlarged liver with multiple low attenuation areas. Liver biopsy revealed sinusoidal infiltration by small size cells identified as Kappa light chain-producing primitive plasma cells by immunohistochemistry. The patient responded to three courses of EDAP. Subsequently he received intensive therapy with busulfan/melfalan and a peripheral blood stem cell transplantation enriched for CD34+ cells from his HLA-identical brother. No acute graft-versus-host disease was detected. Now, 12 months after transplant, the patient is asymptomatic.
authors.affiliation: Servicio de Hematología, Hospital Universitario La Fe, Valencia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Solves
authors.forename: J
authors.initials: J
authors.lastname: de la Rubia
authors.forename: I
authors.initials: I
authors.lastname: Jarque
authors.forename: J
authors.initials: J
authors.lastname: Cervera
authors.forename: G F
authors.initials: GF
authors.lastname: Sanz
authors.forename: F J
authors.initials: FJ
authors.lastname: Vera-Sempere
authors.forename: M A
authors.initials: MA
authors.lastname: Sanz
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology*