Luminal epithelial antigen (LEA.135) expression in adenocarcinoma of the colon.
BACKGROUND
Luminal Epithelial Antigen (LEA.135) is a cell surface glycoprotein, whose expression has been shown to have prognostic significance in breast carcinoma and transitional cell carcinoma of the bladder, but has not been previously evaluated in adenocarcinoma of the colon.


METHODS
This study examines LEA.135 expression in 134 archival cases of colon adenocarcinoma obtained from Wellington Hospital Pathology Department between 1985 and 1990 inclusive. The findings were compared with tumor grade, stage and survival, to determine whether LEA.135 could serve as a useful indicator of the progression of colonic adenocarcinoma.


RESULTS
Analysis of results showed that LEA.135 expression was not related to depth of invasion (p = 0.097), grade (p = 0.14) or clinical outcome (p = 0.27). Both luminal and cytoplasmic labelling of LEA.135 was seen in tumor cells however there was no association between LEA.135 distribution and either tumor grade or patient survival.


CONCLUSIONS
The results suggest that the expression of LEA.135 does not provide a useful indication of clinical progression or outcome in patients with colonic adenocarcinoma.
Miles
S E
SE
Department of Surgery, Wellington School of Medicine, New Zealand.
Kenwright
D N
DN
Gaskell
D J
DJ
Christie
R M
RM
Thornton
A
A
Delahunt
B
B
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000954:Antigens, Surface / Q000032:analysis; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis* / Q000276:immunology
D000954:Antigens, Surface; C504584:LEA-135 protein, human; D008562:Membrane Glycoproteins