title: Wilms' tumor: a 25-year review of the role of preoperative chemotherapy.
abstract: OBJECTIVE
  This 25-year population based, single institution review was conducted to investigate the impact of preoperative chemotherapy on surgical and histological staging in patients with Wilms' tumors.
  
  
  RESULTS
  Forty-nine patients under the age of 15 years were identified from case notes to have had histologically verified Wilms' tumors over the 25-year period from January 1972 to December 1996. Twenty-six patients were treated initially with preoperative chemotherapy, 23 with immediate surgery. Eleven had treatment randomized within the UKCCSG WT9101 trial (UKWT3), and the remainder received initial treatment according to unit policy. Surgical stages in the two groups (preoperative chemotherapy and immediate surgery) were respectively, stage 1:14(28.5%) and 11 (22.5%), stage II: one (2%) and eight (16.3%), stage III: 11 (22.5%) and four (8.2%). Seven patients had clinical stage IV disease at presentation. Histology results were favorable in 45 patients and unfavorable in four. All patients received chemotherapy during treatment, whereas 25 (51%) also received radiotherapy. No significant difference was evident in the two groups with respect to treatment-related morbidity. Five patients relapsed, three of whom died within the period of review, but a fourth has since died.
  
  
  CONCLUSIONS
  This study suggests that the use of preoperative chemotherapy does not put the patient at increased risk of postoperative morbidity or reduced survival. The distribution of surgical stages suggests that limited tumor downstaging may have occurred as a result of preoperative chemotherapy.
authors.affiliation: Department of Child Health, Queen's Medical Centre, University of Nottingham, England.
authors.forename: M L
authors.initials: ML
authors.lastname: Capra
authors.forename: D A
authors.initials: DA
authors.lastname: Walker
authors.forename: W M
authors.initials: WM
authors.lastname: Mohammed
authors.forename: L
authors.initials: L
authors.lastname: Kapila
authors.forename: P R
authors.initials: PR
authors.lastname: Barbor
authors.forename: M
authors.initials: M
authors.lastname: Sokal
authors.forename: K
authors.initials: K
authors.lastname: Robson
authors.forename: M
authors.initials: M
authors.lastname: Hewitt
authors.forename: R
authors.initials: R
authors.lastname: Stewart
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D009396:Wilms Tumor / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery*