title: Three different autoimmune bullous diseases in one family: is there a common genetic base?
abstract: We report an unusual familial occurrence of autoimmune bullous diseases. Three members of a family suffered from three different autoimmune bullous diseases: pemphigus vulgaris (PV), linear IgA disease (LAD) and cicatricial pemphigoid (CP). The HLA type was determined in five family members: all were positive for HLA-DQ5/DR6, which is reported to be associated with susceptibility to PV. The CP patient was DQ7(3) positive, which is in concordance with enhanced susceptibility to ocular CP and CP. The LAD patient was B8 and DR3 negative but positive for HLA-A1. Our study supports the hypothesis that there is a genetically transmitted susceptibility to autoimmune bullous diseases but that additional factors seem necessary actually to develop a particular disease.
authors.affiliation: Department of Dermatology, University Hospital, Deutschhausstrasse 9, 35037 Marburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Kirtschig
authors.forename: H
authors.initials: H
authors.lastname: Mittag
authors.forename: M
authors.initials: M
authors.lastname: Wolf
authors.forename: A
authors.initials: A
authors.lastname: Gorski
authors.forename: R
authors.initials: R
authors.lastname: Happle
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000235:genetics*; D005192:Family Health; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D010375:Pedigree; D010390:Pemphigoid, Benign Mucous Membrane / Q000235:genetics / Q000276:immunology; D010392:Pemphigus / Q000235:genetics / Q000276:immunology; D012872:Skin Diseases, Vesiculobullous / Q000235:genetics* / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A