Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system.
We identified a novel member of the Ikaros gene family, which has critical roles in the development of lymphoid lineages. This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system. Eos protein could interact with itself and Ikaros protein through its C-terminal portion in the yeast two hybrid assay. These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue.
Honma
Y
Y
Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima City, Japan.
Kiyosawa
H
H
Mori
T
T
Oguri
A
A
Nikaido
T
T
Kanazawa
K
K
Tojo
M
M
Takeda
J
J
Tanno
Y
Y
Yokoya
S
S
Kawabata
I
I
Ikeda
H
H
Wanaka
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001253:Astrocytes / Q000166:cytology; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification; D002490:Central Nervous System / Q000737:chemistry; D004268:DNA-Binding Proteins; D051740:Ikaros Transcription Factor; D017403:In Situ Hybridization; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000302:isolation & purification; D017933:Peripheral Nervous System / Q000737:chemistry; D011485:Protein Binding; D012333:RNA, Messenger / Q000302:isolation & purification; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D016335:Zinc Fingers / Q000235:genetics*
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C497238:Zfpn1a1 protein, mouse; C118760:Zfpn1a4 protein, mouse; D051740:Ikaros Transcription Factor