title: Medicinal flowers. I. Aldose reductase inhibitors and three new eudesmane-type sesquiterpenes, kikkanols A, B, and C, from the flowers of Chrysanthemum indicum L.
abstract: The methanolic extract from the flowers of Chrysanthemum indicum L., Chrysanthemi Indici Flos, was found to show inhibitory activity against rat lens aldose reductase. By bioassay-guided separation, the active components, such as flavone and flavone glycosides, were isolated from the extract together with three new eudesmane-type sesquiterpenes, kikkanols A, B, and C. The structures of kikkanols A, B, and C were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Morikawa
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: I
authors.initials: I
authors.lastname: Toguchida
authors.forename: S
authors.initials: S
authors.lastname: Harima
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D011723:Chrysanthemum cinerariifolium / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; C119778:kikkanol A; C119779:kikkanol B; C119780:kikkanol C; D000449:Aldehyde Reductase