Emergence of fluoroquinolone resistance among multiply resistant strains of Streptococcus pneumoniae in Hong Kong.
The MICs of 17 antimicrobial agents for 181 Streptococcus pneumoniae strains were determined by the E-test. Overall, 69.1% were penicillin resistant (MIC > 0.06 microgram/ml). Resistance to ciprofloxacin (MIC > 2 microgram/ml), levofloxacin (MIC > 2 microgram/ml), or trovafloxacin (MIC > 1 microgram/ml) was found in 12.1, 5.5, or 2.2% of the strains, respectively. These high rates of resistance raise concerns for the future.
Ho
P L
PL
Department of Microbiology, Division of Infectious Diseases, University of Hong Kong, Hong Kong. plho@hkucc.hku.hk
Que
T L
TL
Tsang
D N
DN
Ng
T K
TK
Chow
K H
KH
Seto
W H
WH
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D018432:Drug Resistance, Multiple; D024841:Fluoroquinolones; D006723:Hong Kong; D006801:Humans; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones