title: Progression of defects in the central 10-degree visual field of patients with retinitis pigmentosa and choroideremia.
abstract: OBJECTIVE
  To determine the progression of defects in the central 10-degree visual field in patients with retinitis pigmentosa and choroideremia by means of univariate linear regression with respect to the mean deviation.
  
  
  METHODS
  In a retrospective study, results of automated static perimetry in the central 10-degree visual field were reviewed for patients with retinitis pigmentosa and choroideremia. Univariate linear regression of mean deviation was undertaken for each eye that had field data from at least five tests in addition to the prior static perimetric experience during a period of 3.5 years or more. Data from 30 eyes of 16 patients fulfilled eligibility requirements; the mean number of fields was 5.8 (range, five to 10) and the mean follow-up period was 64 months (range, 42 to 97 months). Eyes were classified as progressive if the regression coefficient was negative and significantly different from zero, with a P value of less than .05.
  
  
  RESULTS
  Among 14 patients in whom both eyes were eligible for univariate linear regression analysis, a statistically significant progression was demonstrated in both eyes in four patients, only in one eye in five patients, and in neither eye in five patients. One of two patients, in whom only one eye was eligible for the study, showed significant progression in the eye. Overall, 14 (47%) of 30 eyes showed statistically significant progression with respect to the mean deviation. No eye showed significant improvement.
  
  
  CONCLUSIONS
  Automated static perimetry of the central 10-degree visual field measured approximately once or twice a year demonstrated the progressive nature of the disease with the use of univariate linear regression of mean deviation in 47% of eyes with retinitis pigmentosa and choroideremia during the follow-up period of 3.5 years or more. These results may be useful in understanding the clinical course of the diseases and counseling patients.
authors.affiliation: Department of Ophthalmology, Yamanashi Medical University, Tamaho, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hirakawa
authors.forename: H
authors.initials: H
authors.lastname: Iijima
authors.forename: T
authors.initials: T
authors.lastname: Gohdo
authors.forename: M
authors.initials: M
authors.lastname: Imai
authors.forename: S
authors.initials: S
authors.lastname: Tsukahara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015794:Choroideremia / Q000175:diagnosis* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D014786:Vision Disorders / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields