[Inflammatory bowel disease and pregnancy: clinical study of mutual influence, clinical course and treatment].
We studied the clinical courses of 70 pregnancies in 47 women with ulcerative colitis (UC) and 18 pregnancies in 12 women with Crohn's disease (CD) retrospectively. We concluded as follows. 1. Pregnancy has less influence on the course of UC. 2. The patients with UC who kept remission for more than 1 year before conception have less risk of relapse and severity during pregnancy. 3. The patients with active UC at the time of conception tend to worsen during pregnancy. The patients whose onset of UC is during pregnancy tend to worsen. 4. UC has a little influence on the course of pregnancy except severe active disease. 5. It is not obtained that pregnancy becomes a relapsing factor of CD. 6. CD during pregnancy has little influences on the course of pregnancy, if it is remitted. 7. Salazosulfapyridine and corticosteroids therapy has less influence on the fetus and the course of pregnancy.
Oriuchi
T
T
Third Department of Internal Medicine, Tohoku University School of Medicine.
Hiwatashi
N
N
Katsurashima
Y
Y
Noguchi
M
M
Kinouchi
Y
Y
Toyota
T
T
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D003093:Colitis, Ulcerative / Q000503:physiopathology / Q000628:therapy*; D003424:Crohn Disease / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology / Q000628:therapy*; D011256:Pregnancy Outcome; D012074:Remission Induction; D012189:Retrospective Studies; D012460:Sulfasalazine / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D005765:Gastrointestinal Agents; D012460:Sulfasalazine