Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency.
To determine if circadian clock function is affected by thiamine deficiency, the rhythm of locomotor (wheel-running) activity was measured in a murine model of dietary thiamine deficiency. About 1 month before the expected onset of overt neurological illness, locomotor rhythmicity in deficient animals exhibited a shortened free-running period without a change in amplitude. This effect was fully reversible by thiamine administration. Disordered circadian timekeeping may contribute to altered physiological responses in Wernicke's encephalopathy.
Bennett
M R
MR
Department of Neurology, University of Massachusetts Medical School, Worcester 01655, USA.
Schwartz
W J
WJ
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003624:Darkness; D004032:Diet; D008027:Light; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D017440:Photoperiod; D013831:Thiamine / Q000494:pharmacology; D013832:Thiamine Deficiency / Q000503:physiopathology*
D013831:Thiamine