title: Progression of coronary artery calcification: a pilot study.
abstract: OBJECTIVE
  To describe individual changes in the quantity of coronary artery calcification (CAC) measured by electron beam computed tomography (CT) and determine the rate of change in the quantity of CAC during a 3.5-year period.
  
  
  METHODS
  Eighty-eight consecutive participants (51 men at least 30 years of age and 37 women at least 40 years of age) from a community-based CAC study were invited for a follow-up examination. Established coronary artery disease risk factors were studied at baseline. CAC score was measured by electron beam CT at baseline and follow-up.
  
  
  RESULTS
  Of the 88 invited participants, 82 (93%) returned for a follow-up examination. Considerable variation existed among the participants in the extent of CAC score change. On average, CAC score increased over time by an estimated 24% each year (P<0.05). The relative increase in CAC score over time was significantly lower for older than for younger participants but did not vary significantly by sex.
  
  
  CONCLUSIONS
  The ability to recruit follow-up participants in this pilot study and to detect significant change in CAC score over time provides evidence that electron beam CT is useful for studying progression of CAC in a sample and may be a valuable procedure for assessing the effectiveness of clinical interventions designed to retard progression of coronary atherosclerosis.
authors.affiliation: Department of Epidemiology, University of Michigan, Ann Arbor, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Maher
authors.forename: L F
authors.initials: LF
authors.lastname: Bielak
authors.forename: J A
authors.initials: JA
authors.lastname: Raz
authors.forename: P F
authors.initials: PF
authors.lastname: Sheedy
authors.forename: R S
authors.initials: RS
authors.lastname: Schwartz
authors.forename: P A
authors.initials: PA
authors.lastname: Peyser
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000000981:diagnostic imaging; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000473:pathology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects; D012307:Risk Factors; D014057:Tomography, X-Ray Computed