Study on the distribution of radioactive trace elements in vitamin D-overloaded rats using the multitracer technique.
The uptake and distribution of radioisotopes of beryllium, calcium, scandium, vanadium, chromium, manganese, iron, cobalt, nickel, zinc, gallium, arsenic, strontium and barium in vitamin D (VD)-overloaded rats were investigated and compared with those in control rats, using the multitracer technique. Each element revealed its characteristic distribution among various organs in control and VD-overloaded rats. For some elements, such as cobalt and chromium, the distribution patterns in them were significantly different. These results are discussed in terms of the metabolism of the elements in rats.
Hirunuma
R
R
Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan. rhiru@postman.riken.go.jp
Endo
K
K
Enomoto
S
S
Ambe
S
S
Ambe
F
F
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D015519:Bone Density; D002118:Calcium / Q000097:blood; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism; D008297:Male; D011849:Radioactive Tracers; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014807:Vitamin D / Q000494:pharmacology*
D011849:Radioactive Tracers; D014807:Vitamin D; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002118:Calcium