N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer.
N-Aroyl-, N-Arylsulfonyl-, and N-Aryl-S,S-dimethyliminosulfuranes have been synthesized and evaluated as potential dermal penetration enhancers. The title compound and Azone exhibit similar activities for permeation of hydrocortisone through hairless mouse skin.
Strekowski
L
L
Department of Chemistry, Georgia State University, Atlanta 30303, USA.
Henary
M
M
Kim
N
N
Michniak
B B
BB
D000818:Animals; D051379:Mice; D008812:Mice, Hairless; D008954:Models, Biological; D012869:Skin Absorption / Q000187:drug effects*; D013457:Sulfur Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
C119492:N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane; D013457:Sulfur Compounds