Sarcoidosis in a patient with linear IgA disease.
We report a patient with four conditions in association with linear IgA disease (LAD), only three of which have been reported previously; these latter are ulcerative colitis, autoimmune thyroid disease and carcinoma of the colon, although the carcinoma may have been caused by the ulcerative colitis in this case. Recently, our patient also presented with respiratory symptoms and was found to have sarcoidosis as well, a previously unreported association of this autoimmune bullous disorder. The aetiology of this development may be related to the patient's HLA status or possibly to his treatment with the immunosuppressive agent cyclophosphamide; it is also possible that it is coincidental.
Porter
W M
WM
Department of Dermatology, Chelsea & Westminster Hospital, 369 Fulham Road, London, UK.
Hardman
C M
CM
Leonard
J N
JN
Fry
L
L
D000230:Adenocarcinoma / Q000150:complications / Q000276:immunology; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications*; D001485:Basement Membrane / Q000276:immunology; D003093:Colitis, Ulcerative / Q000150:complications / Q000276:immunology; D003110:Colonic Neoplasms / Q000150:complications / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000276:immunology; D012867:Skin / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology
D007070:Immunoglobulin A