title: Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolism.
abstract: BACKGROUND
  Hypertension is an important clinical problem and is often accompanied by left ventricular (LV) hypertrophy and dysfunction. Whether the myocardial high-energy phosphate (HEP) metabolism is altered in human hypertensive heart disease and whether this is associated with LV dysfunction is not known.
  
  
  RESULTS
  Eleven patients with hypertension and 13 age-matched healthy subjects were studied with magnetic resonance imaging at rest and with phosphorus-31 magnetic resonance spectroscopy at rest and during high-dose atropine-dobutamine stress. Hypertensive patients showed higher LV mass (98+/-28 g/m2) than healthy control subjects (73+/-13 g/m2, P<0.01). LV filling was impaired in patients, reflected by a decreased peak rate of wall thinning (PRWThn), E/A ratio, early peak filling rate, and early deceleration peak (all P<0. 05), whereas systolic function was still normal. The myocardial phosphocreatine (PCr)/ATP ratio determined in patients at rest (1. 20+/-0.18) and during stress (0.95+/-0.25) was lower than corresponding values obtained from healthy control subjects at rest (1.39+/-0.17, P<0.05) and during stress (1.16+/-0.18, P<0.05). The PCr/ATP ratio correlated significantly with PRWThn (r=-0.55, P<0.01), early deceleration peak (r=-0.56, P<0.01), and with the rate-pressure product (r=-0.53, P<0.001).
  
  
  CONCLUSIONS
  Myocardial HEP metabolism is altered in patients with hypertensive heart disease. In addition, there is an association between impaired LV diastolic function and altered myocardial HEP metabolism in humans. The level of myocardial PCr/ATP is most likely determined by the level of cardiac work load.
authors.affiliation: Department of Radiology and Cardiology, University Medical Center, Leiden The Netherlands. Lamb@RULLF2.Medfac.Leidenuniv.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: H P
authors.initials: HP
authors.lastname: Beyerbacht
authors.forename: A
authors.initials: A
authors.lastname: van der Laarse
authors.forename: B C
authors.initials: BC
authors.lastname: Stoel
authors.forename: J
authors.initials: J
authors.lastname: Doornbos
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D003971:Diastole; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D018487:Ventricular Dysfunction, Left / Q000378:metabolism*
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate