title: Efficacy and local tolerability of povidone iodine and octenidine hydrochloride solution for the antiseptic preparation of the orificium urethrae.
abstract: In a randomized clinical study, 61 hospitalized men were examined to test the local tolerability and antimicrobial efficacy of antiseptic treatment of the genitals with povidone iodine versus octenidine hydrochloride solution. Antibacterial efficacy was established by comparing the total aerobic bacterial colony count from standardized swabs from the orificium urethrae externum before, immediately after, and 30 and 60 min after antisepsis. Tolerability was assessed by dermatoscopy, applying a scale to rate the criteria of reddening, erosions and microbleeding. pH-value was taken and the nitracin yellow test carried out at several intervals. Patients assessed sensations (itching, burning, warmth, cold tension) in visual analogue scales. The test for equivalence in efficacy of both antiseptic agents produced no significant result (P = 0.3). The sum score of tolerability produced a better result for povidone iodine. In addition, the drop in the pH value after observed antisepsis with povidone iodine provides an additional protective mechanism against bacterial colonization.
authors.affiliation: Ernst-Moritz-Arndt-Universität Greifswald, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Rudolph
authors.forename: F
authors.initials: F
authors.lastname: Fritze
authors.forename: K
authors.initials: K
authors.lastname: Reimer
authors.forename: K J
authors.initials: KJ
authors.lastname: Klebingat
authors.forename: A
authors.initials: A
authors.lastname: Kramer
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001420:Bacteria, Aerobic / Q000187:drug effects; D015169:Colony Count, Microbial; D003428:Cross Infection / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007097:Imines; D008297:Male; D010413:Penis / Q000737:chemistry / Q000187:drug effects; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011292:Premedication; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012867:Skin / Q000737:chemistry / Q000187:drug effects; D011795:Surveys and Questionnaires; D014521:Urethra / Q000187:drug effects / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D011206:Povidone-Iodine; C034213:octenidine