[The pathogenesis of liver functional disorders after cholecystectomy in cholelithiasis].
OBJECTIVE
To study hepatic function after cholecystectomy and the role of absorptive-excretory function of the liver and hormonal factors in development of postcholecystectomy syndrome.


METHODS
106 patients long after cholecystectomy for cholelithiasis were examined for absorptive-excretory function of the liver and blood hormones (hydrocortisone, insulin, gastrin, thyroxine, triiodothyronine, thyrotropine). I-131-bengal-rose hepatography, dynamic hepatobiliscintigraphy with brommeside-Tc-99m, radioimmunoassay were employed.


RESULTS
Impairment, often subclinical, of hepatic absorption and excretion after cholecystectomy was found in 94% of the patients. External function of the liver after cholecystectomy was disturbed depending on the condition of its absorptive-excretory function. Hepatic dysfunctions and changes in blood hormones correlated.


CONCLUSIONS
Absorptive-excretory function and hormonal factors are essential in pathogenesis of postcholecystectomy syndrome.
Aksenova
E M
EM
Vakhrushev
Ia M
IaM
D002769:Cholelithiasis / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006728:Hormones / Q000097:blood; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood; D017562:Postcholecystectomy Syndrome / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
D006728:Hormones; D018377:Neurotransmitter Agents