title: Insulin-like growth factor 1 and growth hormone binding protein in depression: a preliminary communication.
abstract: This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, CA, USA.
authors.forename: B
authors.initials: B
authors.lastname: Franz
authors.forename: D J
authors.initials: DJ
authors.lastname: Buysse
authors.forename: C R
authors.initials: CR
authors.lastname: Cherry
authors.forename: N S
authors.initials: NS
authors.lastname: Gray
authors.forename: V J
authors.initials: VJ
authors.lastname: Grochocinski
authors.forename: E
authors.initials: E
authors.lastname: Frank
authors.forename: D J
authors.initials: DJ
authors.lastname: Kupfer
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002352:Carrier Proteins / Q000378:metabolism*; D003866:Depressive Disorder / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis; D011986:Receptors, Somatotropin / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D007334:Insulin-Like Growth Factor I