title: Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
abstract: Three C46 (1-3) and three C30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.
authors.affiliation: Research Institute of Drug Development, College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lim
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
authors.forename: C J
authors.initials: CJ
authors.lastname: Shim
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: H
authors.initials: H
authors.lastname: Lee
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011108:Polymers / Q000302:isolation & purification / Q000494:pharmacology*; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene