title: Born to clot: the European burden.
abstract: Venous thrombosis is a common problem, predominantly afflicting people of European origin. This European predisposition has been explained to some extent by the recent characterization of factor V Leiden, and the G20210A prothrombin variant. Although it is clear that factor V Leiden is largely confined to Europeans, the world distribution of the prothrombin variant is not known. We have analysed samples from 22 different non-European countries and shown that this prothrombin variant is very rare outside Europe: one case occurring in India. The reason for the confined distribution of these two mutations is unclear.
authors.affiliation: MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, The John Radcliffe, Oxford.
authors.forename: D C
authors.initials: DC
authors.lastname: Rees
authors.forename: N H
authors.initials: NH
authors.lastname: Chapman
authors.forename: M T
authors.initials: MT
authors.lastname: Webster
authors.forename: J F
authors.initials: JF
authors.lastname: Guerreiro
authors.forename: J
authors.initials: J
authors.lastname: Rochette
authors.forename: J B
authors.initials: JB
authors.lastname: Clegg
mesh_terms: D000349:Africa / Q000208:ethnology; D000569:Americas / Q000208:ethnology; D001208:Asia / Q000208:ethnology; D001315:Australia / Q000208:ethnology; D005165:Factor V / Q000235:genetics*; D005828:Genetics, Population; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D011516:Prothrombin / Q000235:genetics; D020246:Venous Thrombosis / Q000208:ethnology / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin