Spin doctors: new innovations for centrifugal apheresis.
The preparation of plasma from blood has a long history dating back to the early 1900s when the concept of blood washing replaced the traditional blood letting. Over the next 57 years landmark discoveries such as centrifugal and membrane filtration systems led to different and rapid plasma, solute, and cell separation. These were not singular events but rather events influenced by the converging chemical, physiological, and engineering advances that have characterized the latter half of the 20th century. These events have led to entire new fields of biomedical research. The biotechnology for on-line plasma separation and plasma treatment has opened a new era, expanding the application of extracorporeal technology to modern therapeutic medicine. The association of biochemical or cellular abnormalities with various disease states provides the rationale for therapeutic plasma exchange (the removal of large amounts of patient's plasma, alone or with replacement with crystalloid) and therapeutic cytopheresis (removal of cellular elements). The purpose of this review is to provide a historical picture of the innovative ideas of the spin doctors and their devices, which predate the centrifugal blood and cell separators commonplace to any hospital or blood bank worldwide. The emphasis is to define the historical events and their impacts on the development of centrifugal devices and apheresis technologies.
Kambic
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Department of Biomedical Engineering, Cleveland Clinic Foundation, Ohio 44195, USA.
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D001781:Blood Component Removal / Q000266:history / Q000295:instrumentation* / Q000706:statistics & numerical data; D002498:Centrifugation / Q000266:history / Q000295:instrumentation* / Q000706:statistics & numerical data; D049673:History, 20th Century; D007391:International Cooperation; D012042:Registries / Q000706:statistics & numerical data; D012106:Research / Q000266:history