[The pathogenesis of biliary stone formation and its prevention in biliary tract diseases].
OBJECTIVE
Elucidation of some pathogenetic mechanisms of cholelithiasis in biliary diseases.


METHODS
The examination of 45 patients suffering from gall bladder and biliary tracts lesions complicated with cholelithiasis included: measurements of bilirubin, bile acids and cholesterol in bile portions B and C; estimation of the cholatocholesterol coefficient; duodenomanometry; radioimmunoassay of thyroxine, thyrotropine, insulin, hydrocortisone and gastrin in peripheral blood.


RESULTS
A correlation was found between cholelithiasis and changes in intraduodenal pressure as well as secretion of hormones (gastrin, insulin, hydrocortisone, thyroxine, thyrotropine). Combined therapy including xenofalk and polyphepan in biliary diseases produced a good therapeutic response. Besides relief of clinical symptoms and improvement of intraduodenal pressure, positive changes were seen in bile lithogenicity.


CONCLUSIONS
The data obtained contribute to better understanding of cholelithiasis and planning of relevant preventive measures.
Vakhrushev
Ia M
IaM
Khokhlacheva
N A
NA
D000293:Adolescent; D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002769:Cholelithiasis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D004386:Duodenum / Q000503:physiopathology; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D008031:Lignin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011312:Pressure
D002756:Cholagogues and Choleretics; D006728:Hormones; D002635:Chenodeoxycholic Acid; C056995:polyfepan; D008031:Lignin