Total synthesis of an antioxidant isolated from yeast via palladium-catalyzed coupling and its application for related compounds.
A total synthesis of an antioxidant (1) having a benzofuran skeleton was achieved in four steps via the palladium(0)-catalyzed cross-coupling reaction. We also prepared several related compounds bearing a variety of aromatic or heterocyclic rings. Some of these compounds demonstrate more potent than 1 for antioxidative activity using guinea pig liver microsomes.
Jinno
S
S
Central Research Laboratory, Nippon Suisan Kaisha, Ltd., Hachioji, Tokyo, Japan.
Okita
T
T
Inouye
K
K
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D002384:Catalysis; D004149:Dioxoles / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010165:Palladium / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000737:chemistry*
D000975:Antioxidants; D004149:Dioxoles; D010165:Palladium