title: Urinary nuclear matrix protein 22 as a new marker for the screening of urothelial cancer in patients with microscopic hematuria.
abstract: OBJECTIVE
  The aim of the present study was to determine the clinical usefulness of nuclear matrix protein 22 (NMP22) as a new urinary marker for the screening of urothelial cancer in patients with microscopic hematuria, especially in comparison with that of voided urine cytology.
  
  
  METHODS
  Patients with microscopic hematuria detected at a health examination, who were advised by a consulted urologist to have a cystoscopical examination, were asked to enter this study. Urine samples were collected before cystoscopy and divided into two portions for NMP22 test and voided urine cytology.
  
  
  RESULTS
  Of the 309 patients with microscopic hematuria, 22 cases (7.1%) of urothelial cancer and one case of prostate cancer were detected. For the other cases, 128 (41.4%) were of benign diseases and 158 (51.1%) were designated as having no evidence of disease (NED). The median NMP22 values for urothelial cancer, other diseases and NED were 35.5, 6.7 and 6.0 U/mL, respectively, with 95% confidence intervals of 19.9-228.2, 5.1-9.3 and 5.4-7.2, respectively. The sensitivity of the NMP22 test for urothelial cancer was 90.9% (20/22), whereas the sensitivity of voided urine cytology was only 54.5% (12/22).
  
  
  CONCLUSIONS
  The present study indicates that urinary NMP22 is a useful tool for the screening of urothelial cancer in patients with microscopic hematuria.
authors.affiliation: University of Tsukuba, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Miyanaga
authors.forename: H
authors.initials: H
authors.lastname: Akaza
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: S
authors.initials: S
authors.lastname: Ishikawa
authors.forename: R
authors.initials: R
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Ohtani
authors.forename: K
authors.initials: K
authors.lastname: Kawabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Obata
authors.forename: Y
authors.initials: Y
authors.lastname: Hirao
authors.forename: T
authors.initials: T
authors.lastname: Kotake
authors.forename: H
authors.initials: H
authors.lastname: Ohmori
authors.forename: J
authors.initials: J
authors.lastname: Kumazawa
authors.forename: K
authors.initials: K
authors.lastname: Koiso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000652:urine*; D003556:Cystitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006417:Hematuria / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000652:urine*; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000652:urine; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000652:urine; D016482:Urinalysis; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine; D014545:Urinary Calculi / Q000175:diagnosis / Q000652:urine; D019459:Urothelium / Q000737:chemistry
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; C100379:nuclear matrix protein 22