Parvovirus B19 infection associated with myocarditis following adult cardiac transplantation.
A 56-year-old woman underwent an uneventful cardiac transplantation due to dilated cardiomyopathy. One week later the patient developed clinical and histological signs of myocarditis. We report for the first time a case of myocarditis in an adult heart transplant recipient, possibly induced by parvovirus B19, as evidenced by the finding of specific IgM in serum and specific DNA in the myocardial cells. Furthermore, this is the first time parvovirus B19 DNA has been observed in the myocardium of an adult. In conclusion, parvovirus B19 should be recognized as a potential pathogen causing myocarditis in heart transplant recipients. In order to establish a definite and rapid diagnosis, a search for specific IgM should be supplemented with PCR investigations of serum and myocardial biopsies when available.
Heegaard
E D
ED
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Eiskjaer
H
H
Baandrup
U
U
Hornsleth
A
A
D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology*; D010322:Parvoviridae Infections / Q000209:etiology*; D016732:Parvovirus B19, Human
D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M