Discovery of a novel series of selective MMP inhibitors: identification of the gamma-sulfone-thiols.
We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol.
Freskos
J N
JN
Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA.
Mischke
B V
BV
DeCrescenzo
G A
GA
Heintz
R
R
Getman
D P
DP
Howard
S C
SC
Kishore
N N
NN
McDonald
J J
JJ
Munie
G E
GE
Rangwala
S
S
Swearingen
C A
CA
Voliva
C
C
Welsch
D J
DJ
D005109:Extracellular Matrix / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D011480:Protease Inhibitors; D013438:Sulfhydryl Compounds; D008666:Metalloendopeptidases