Levels of proinflammatory cytokines in plasma after pneumoccoccal immunization in human immunodeficiency virus type 1-infected patients.
To ascertain if immunization with pneumococcal polysaccharide vaccine is associated with rises in the levels of proinflammatory cytokines in the plasma of human immunodeficiency virus type 1 (HIV-1)-infected patients, the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were measured serially after immunization. IL-6 levels rose an average of 2.2- and 2.1-fold 6 and 8 h after immunization, respectively, but TNF-alpha levels remained unchanged. The levels of these cytokines were stable in unimmunized controls. Immunization with pneumococcal polysaccharide vaccine induces increases in the levels of IL-6 in the plasma of persons with HIV-1 infection.
Valdez
H
H
Case Western Reserve University Center for AIDS Research and University Hospitals of Cleveland, Cleveland, Ohio 44106-5083, USA. valdez.hernan@clevlandactu.org
Purvis
S
S
Asaad
R
R
Valerio
I
I
Sha
B E
BE
Landay
A L
AL
Lederman
M M
MM
D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D007114:Immunization; D015850:Interleukin-6 / Q000097:blood; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D001428:Bacterial Vaccines; D016207:Cytokines; D015850:Interleukin-6; D022242:Pneumococcal Vaccines; D014409:Tumor Necrosis Factor-alpha