title: Extraosseous metastases of hepatocellular carcinoma detection and therapeutic assessment with Tc-99m PMT SPECT.
abstract: Owing to recent advances in imaging technology and radiologic intervention, survival rates in patients with hepatocellular carcinoma have improved markedly. However, such prolonged survival has resulted in an increase in extrahepatic metastases. Tc-99m (Sn)-N-pyridoxyl-5-methyltryptophan (Tc-99m PMT), developed for hepatobiliary scintigraphy, has been used to visualize extrahepatic metastases, with most related reports limited to osseous metastases. The authors report two cases of hepatocellular cancer presenting as a hypopharyngeal metastasis and intraperitoneal dissemination along the tract of a fine-needle biopsy. Lesions undetectable on planar imaging could be visualized by Tc-99m PMT SPECT.
authors.affiliation: Department of Radiology, Kochi Medical School, Japan. hayasen@kochi-ms.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Hayase
authors.forename: M
authors.initials: M
authors.lastname: Fukumoto
authors.forename: D
authors.initials: D
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Kariya
authors.forename: N
authors.initials: N
authors.lastname: Akagi
authors.forename: A
authors.initials: A
authors.lastname: Kurohara
authors.forename: N
authors.initials: N
authors.lastname: Hisa
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000556:secondary*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009366:Neoplasm Seeding; D015609:Organotechnetium Compounds; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D011730:Pyridoxal / Q000031:analogs & derivatives*; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014364:Tryptophan / Q000031:analogs & derivatives*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C038081:technetium Tc 99m pyridoxyl-5-methyltryptophan; D011730:Pyridoxal; D014364:Tryptophan