Effect of cimetidine on development of gastric cancer in rats after gastrojejunostomy.
OBJECTIVE
To find out if cimetidine has an immunomodulating effect on gastric carcinogenesis in rats.


METHODS
Experimental prospective study.


METHODS
Teaching hospital, Norway.


METHODS
132 male PGV/Mol rats given gastrojejunostomies.


METHODS
Half the rats were given cimetidine in their drinking water postoperatively for a minimum of 38 weeks. They were killed after 52 weeks observation and the stomach was investigated macroscopically and microscopically.


METHODS
In the cimetidine fed group 19/48 animals developed cancer (49%), versus 12/43 (28%) in the control group (p = 0.24).


CONCLUSIONS
Cimetidine had no immunomodulatory effect on the development of gastric cancer in rats.
Hortemo
G S
GS
Department of Surgery, University of Bergen, Haukeland Sykehus, Norway.
Maartmann-Moe
H
H
Rökke
O
O
Viste
A
A
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D016009:Chi-Square Distribution; D002927:Cimetidine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D004383:Duodenogastric Reflux / Q000150:complications / Q000209:etiology; D005774:Gastrostomy; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D007582:Jejunostomy; D008297:Male; D011446:Prospective Studies; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D006635:Histamine H2 Antagonists; D002927:Cimetidine