title: Outcome of surgical closure of doubly committed subarterial ventricular septal defect.
abstract: BACKGROUND
  From 1986 to March 1997, 128 patients diagnosed to have doubly committed subarterial ventricular septal defects (VSD) were reviewed. Patients with aortic regurgitation (AR), and aortic valve (AV) deformity or a large left-to-right shunt across the VSD were offered operation. Forty-five patients (27 men, 18 women) agreed to surgical closure of their VSDs.
  
  
  METHODS
  Thirty-eight patients had VSD closure alone, and 7 had an additional AV repair. Other associated defects corrected at operation were closure of atrial septal defects, closure of other ventricular septal defects, ligation of patent ductus arteriosus, and repair of ruptured sinus Valsalva aneurysm.
  
  
  RESULTS
  There was no mortality nor major morbidity associated with operation. In the 26 patients with AR and AV deformity preoperatively, valve repair was performed in 6 patients. The condition of AR improved in 4, and remained unchanged in 22 patients. In the 10 patients with a deformity of the AV and no AR preoperatively, the condition remained unchanged in 5 patients, from whom 1 had valve operation, but progressed in 5 patients postoperatively at a mean follow-up of 6.4 years. In 9 patients with no deformity of the AV and no AR preoperatively, there was no postoperative AR and no progress of valve deformity.
  
  
  CONCLUSIONS
  Excellent results were obtained with VSD closure and AV repair. Surgical closure of VSD, if performed before the onset of AV deformity, may prevent progressive AR. If AV repair is performed after the onset of AV deformity, progressive AR may not always be prevented.
authors.affiliation: Cardiac Department, National University Hospital, and Gleneagles Medical Centre, Singapore.
authors.forename: E K
authors.initials: EK
authors.lastname: Sim
authors.forename: R T
authors.initials: RT
authors.lastname: Grignani
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: S C
authors.initials: SC
authors.lastname: Quek
authors.forename: J C
authors.initials: JC
authors.lastname: Wong
authors.forename: W C
authors.initials: WC
authors.lastname: Yip
authors.forename: C N
authors.initials: CN
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome