title: Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome.
abstract: Non-Hodgkin's lymphoma (NHL) is one of the most common malignancies in patients infected with human immunodeficiency virus (HIV): it occurs 25-60 times more frequently in HIV-infected patients than in the general population. This neoplasm in acquired immunodeficiency syndrome (AIDS) patients is a highly aggressive tumour with a poor prognosis and tends to develop in extranodal sites, such as the central nervous system, digestive tract and bone marrow. NHL involving the paranasal sinuses is rare in HIV-infected patients, and is likely to be confused clinically and radiographically with sinusitis; moreover, its optimal treatment is currently uncertain. We present a case of NHL involving the left maxillary sinus in a patient with AIDS. The patient was treated with systemic chemotherapy (low dose-CHOP), but the malignancy did not respond. Subsequently, he was treated with local maxillary sinus irradiation which resulted in partial regression of the neoplasm and in decrease of local symptoms.
authors.affiliation: Department of Infectious Diseases, Catholic University, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Del Forno
authors.forename: C
authors.initials: C
authors.lastname: Del Borgo
authors.forename: A
authors.initials: A
authors.lastname: Turriziani
authors.forename: F
authors.initials: F
authors.lastname: Ottaviani
authors.forename: A
authors.initials: A
authors.lastname: Antinori
authors.forename: M
authors.initials: M
authors.lastname: Fantoni
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000000981:diagnostic imaging / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone