title: Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase.
abstract: A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy suppressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disruption of XPT1 affects xanthine utilization in vivo and results in a severe reduction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.
authors.affiliation: Institut de Biochimie et Génétique Cellulaires, CNRS UPR9026, F-33077 Bordeaux Cedex, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Guetsova
authors.forename: T R
authors.initials: TR
authors.lastname: Crother
authors.forename: M W
authors.initials: MW
authors.lastname: Taylor
authors.forename: B
authors.initials: B
authors.lastname: Daignan-Fornier
mesh_terms: D005800:Genes, Fungal; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D010430:Pentosyltransferases / Q000235:genetics*; D011687:Purines / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D013489:Suppression, Genetic; D019820:Xanthine / Q000378:metabolism*
chemical_list: D011687:Purines; D019820:Xanthine; D010430:Pentosyltransferases; C024827:xanthine phosphoribosyltransferase; D007041:Hypoxanthine Phosphoribosyltransferase