title: Immune activation in non-treated suicidal major depression.
abstract: In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.
authors.affiliation: Shalvata Mental Health Center, Hod-Hasharon, Israel. mendlov@netvision.net.il
authors.forename: S
authors.initials: S
authors.lastname: Mendlovic
authors.forename: E
authors.initials: E
authors.lastname: Mozes
authors.forename: E
authors.initials: E
authors.lastname: Eilat
authors.forename: A
authors.initials: A
authors.lastname: Doron
authors.forename: J
authors.initials: J
authors.lastname: Lereya
authors.forename: V
authors.initials: V
authors.lastname: Zakuth
authors.forename: Z
authors.initials: Z
authors.lastname: Spirer
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D003863:Depression / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013405:Suicide; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines