title: Treatment results and prognostic factors in inoperable carcinoma of the cervix treated with external plus high dose brachytherapy.
abstract: Patients with inoperable carcinoma of the cervix treated with external plus high dose rate brachytherapy (HDRB), between 1988 and 1995 were evaluated retrospectively. According to stage, 5 year survival rates were 67.3% in stage IIb and 52.6% in stage III (P = 0001) and disease free survival (DFS) rates were 54.0% in stage IIb and 43.9% in stage III (P = 0.01). The following parameters were studied: age; stage; external beam dose; brachytherapy dose; total dose to point A; tumor mass; tumor response rate; bilateral or unilateral invasion of parametria in stage IIb; and bilateral or unilateral invasion of pelvic wall in stage IIIb; and the existence of hydronephrosis. The only significant parameter of 5 year survival and local control was tumor mass (P = 0.003).
authors.affiliation: Ankara University Medical School, Department of Radiation Oncology, Dikimevi, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Garipagaoglu
authors.forename: S
authors.initials: S
authors.lastname: Yalvac
authors.forename: M F
authors.initials: MF
authors.lastname: Kose
authors.forename: G
authors.initials: G
authors.lastname: Tulunay
authors.forename: F
authors.initials: F
authors.lastname: Kayikcioglu
authors.forename: A
authors.initials: A
authors.lastname: Cakmak
authors.forename: A
authors.initials: A
authors.lastname: Haberal
authors.forename: N
authors.initials: N
authors.lastname: Boran
authors.forename: M
authors.initials: M
authors.lastname: Adli
authors.forename: M
authors.initials: M
authors.lastname: Hayran
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy*