Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells.
Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.
Saeki
K
K
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Shoji
Y
Y
Noro
T
T
Miyase
T
T
Nakamura
Y
Y
Funayama
M
M
Isemura
M
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006601:Hexoses / Q000494:pharmacology*; D051379:Mice; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D006601:Hexoses; D005707:Gallic Acid; C060475:1,2,3,6-tetragalloylglucose; D005947:Glucose; C093412:hamamelitannin