title: A glycosyl analogue of diacylglycerol and other antiinflammatory constituents from Inula viscosa.
abstract: Some extracts from Inula viscosa were examined for acute antiinflammatory activity in vivo. Three flavonoids: rhamnocitrin (1), 7-O-methylaromadendrin (3), and 3-O-acetylpadmatin (4); a sesquiterpene lactone, inuviscolide (2); a sesquiterpene acid, ilicic acid (5); and a digalactosyl-diacylglycerol, inugalactolipid A (6), were isolated from the CH2Cl2 extract, identified by spectroscopic methods, and characterized as the topical antiinflammatory principles of this species. All these compounds proved to be effective against 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice, although lacking activity against arachidonic acid-induced edema. In addition, compounds 5 and, markedly, 6 showed notable effects on a multiple-dose murine chronic dermatitis model. This is the first attempt to establish a rationale concerning the documented use of the plant on various skin diseases.
authors.affiliation: Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. V. Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Máñez
authors.forename: M C
authors.initials: MC
authors.lastname: Recio
authors.forename: I
authors.initials: I
authors.lastname: Gil
authors.forename: C
authors.initials: C
authors.lastname: Gómez
authors.forename: R M
authors.initials: RM
authors.lastname: Giner
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
authors.forename: J L
authors.initials: JL
authors.lastname: Ríos
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D016718:Arachidonic Acid; D002351:Carrageenan; D002908:Chronic Disease; D003872:Dermatitis / Q000188:drug therapy; D004075:Diglycerides / Q000302:isolation & purification* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D038143:Inula; D009682:Magnetic Resonance Spectroscopy; D019083:Mediterranean Region; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004075:Diglycerides; D005419:Flavonoids; D012717:Sesquiterpenes; D016718:Arachidonic Acid; D002351:Carrageenan; D013755:Tetradecanoylphorbol Acetate