Modulation of integrin function inhibits HIV transmission to epithelial cells and fertilization.
Integrin-mediated adhesive interactions are viewed in the context of HIV transmission to susceptible cells and fertilization. The ability of a low-molecular-weight non-peptide integrin modulator to inhibit HIV infection (virus-to-cell and cell-to-cell) and sperm-egg fusion is demonstrated. It is concluded that integrin-modulating substances offer significant promise as female-controlled means for preventing sexual transmission of HIV (whatever entity acts as HIV vector in semen and other penile secretions) and as female-controlled contraceptives.
Davidson
J B
JB
Billings Pharmaceutical Company, Chicago, IL 60614, USA. billings@ibm.net
Douglas
G C
GC
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D005306:Fertilization; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009092:Mucous Membrane; D012661:Semen; D013084:Sperm-Ovum Interactions / Q000502:physiology*
D015815:Cell Adhesion Molecules; D016023:Integrins