Combined surgical and immunotherapeutic treatment of patients with fourth stage colon cancer.
Sixty-five patients with the fourth stage colon cancer were subjected to the combined surgical and immunotherapy. The following conclusions are made: (1) surgical elimination of the bulk of tumor mass is a necessary prerequisite for effective immunotherapy; (2) vaccination with autological tumor cells accompanied with bacille bilié de Calmette-Guérin (BCG) as the adjuvant and with interleukin-2 as the immunostimulator effectively prevents metastasizing after successful surgery; (3) the vaccine must necessary contain living tumor cells adequately presenting tumor antigens; and (4) in some cases, immunotherapy causes undesirable autoimmune complications. They can be registered by corresponding inflammation control methods.
Tarasov
V A
VA
Department of Thorax Surgery, Medical Academy of Postgraduated Education, St. Petersburg, Russia.
Filatov
M V
MV
Kisliakova
T V
TV
Noskov
F S
FS
Koloskov
A V
AV
Stavrovietski
V V
VV
Onikienko
S B
SB
Kletchikov
V Z
VZ
Lvov
I V
IV
Yu Varfolomeeva
E
E
Blizniukov
O P
OP
Levina
V V
VV
Kiselevski
M V
MV
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery* / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000276:immunology / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009367:Neoplasm Staging; D009368:Neoplasm Transplantation; D051381:Rats; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D019496:Cancer Vaccines; D007376:Interleukin-2