Acute dysarthria induced by low dose methotrexate therapy in a patient with erythrodermic cutaneous T-cell lymphoma: an unusual manifestation of neurotoxicity.
Neurotoxicity has been associated on rare occasions with methotrexate therapy. We now report the case of a 71-year-old man with erythrodermic cutaneous T-cell lymphoma who developed symptoms of dysarthria and inco-ordination within 1 month of the initiation of oral methotrexate; discontinuation of the therapy then resulted in a gradual resolution of the problems.
Aplin
C G
CG
Kinghorn Dermatology Unit, Royal United Hospital, Bath.
Russell-Jones
R
R
D000208:Acute Disease; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D004401:Dysarthria / Q000139:chemically induced*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000188:drug therapy*
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate