title: Three AML patients with existing or pre-existing intracerebral granulocytic sarcomas who were successfully treated with allogeneic bone marrow transplantations.
abstract: We report three acute myelogenous leukemia (AML) patients who developed intracerebral granulocytic sarcomas (GS) and were successfully treated with allogeneic BMT (allo-BMT). The diagnosis of one patient was AML M2 with myelofibrosis, and the other two patients were AML M4 with eosinophilia (AML M4 Eo), according to the FAB classification. Two patients first experienced a relapse in the brain that resulted in the formation of GS, followed by a relapse in the bone marrow. The remaining patient developed an optic nerve GS after suffering a bone marrow relapse. All three patients received irradiation for the GS and systemic chemotherapy before the allo-BMT. TBI was used for conditioning, and GVHD prophylaxis was with cyclosporine (CsA) and short-term MTX in all three cases. These patients are currently 9 to 37 months post-BMT without relapse. Thus, our experience suggests that allo-BMT is an effective treatment for AML patients with existing or pre-existing intracerebral GS.
authors.affiliation: Department of Internal Medicine, Saiseikai Maebashi Hospital, Gunma Prefecture, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takada
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Sakura
authors.forename: N
authors.initials: N
authors.lastname: Hatsumi
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Shiozaki
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: S
authors.initials: S
authors.lastname: Miyawaki
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous