[The hypotensive effect and tolerance of valsartan (Diovan) in hypertension in a general clinical practice].
OBJECTIVE
An assessment of a hypotensive effect and tolerance of valsartan.


METHODS
In 20 patients with mild and moderate blood hypertension (BH) the latter was registered sphygmomanometrically by N. S. Korotkov and by 24-h monitoring. The initial valsartan dose 80 mg/day was raised to a single daily dose 160 mg in 4 weeks in the absence of adequate correction in tolerance.


RESULTS
The hypotensive effect of Diovan in a dose 80 mg/day was satisfactory or good in 80% of patients. 15% of patients needed elevation of the dose to 160 mg/day. A complete resistance occurred in 1 patient. There were neither unwanted effects nor biochemical evidence of clinically significant renal or hepatic dysfunction due to valsartan. In stable BH correction, the rate of residual hypotensive effect reached 77.4% and 74.5% for systolic and diastolic BP, respectively.


CONCLUSIONS
High effectiveness, good tolerance and safety of valsartan in single doses 80-160 mg/day allow to recommend it in monotherapy of mild and moderate hypertension.
Ivleva
A Ia
AIa
Sokolova
M A
MA
Moiseev
V S
VS
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D013777:Tetrazoles / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D014633:Valine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000068756:Valsartan
D000959:Antihypertensive Agents; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine