[Clinical, bactericidal and pharmacological evaluation of the effects of netromycin].
OBJECTIVE
To analyze clinical, bactericidal effectiveness and pharmacokinetics of wide-spectrum antibiotic netromycin (NM).


METHODS
The trial entered 29 patients: 21 with bronchopulmonary diseases (pneumonia and chronic bronchitis), 5 with exacerbation of chronic pyelonephritis, 2 with infectious endocarditis and 1 with peritonsillar abscess.


RESULTS
Microbiologically, most of the agents (80.36%) showed sensitivity to NM. Pharmacologically, NM persisted long in blood serum and sputum irrespective of the administration mode. Positive clinical dynamics after NM treatment was achieved in all the patients but one who had a peritonsillar abscess.


CONCLUSIONS
NM is highly active against both gram-positive and gram-negative flora. Side effects are minimal.
Sokolova
V I
VI
Orlov
V A
VA
Fomina
I P
IP
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects; D001991:Bronchitis / Q000188:drug therapy*; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D005260:Female; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009428:Netilmicin / Q000494:pharmacology / Q000627:therapeutic use*; D000039:Peritonsillar Abscess / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy*; D011704:Pyelonephritis / Q000188:drug therapy*
D005839:Gentamicins; D009428:Netilmicin