title: Histopathology of a well-functioning hydroxyapatite-coated femoral prosthesis after 52 months.
abstract: A fully hydroxyapatite-coated femoral implant was retrieved during autopsy. This component, provided with a bipolar femoral head, had been inserted for a displaced fracture of the femoral neck 52 months before. Osseointegration of the implant was evident, without any formation of fibrous tissue :39.9% of the perimeter of the prosthesis at the level of its proximal third was interfaced with bone (62.8% at the mid-third and 65.2% at the distal third). Remodeling of bone had ensued. Deposition of bone was most prominent in the calcar zone, along the medial and lateral aspects and around the tip. Proximally, cortical porosity was found to be increased by 73%, whereas medullary bone porosity was increased by a factor of 2. Cell-mediated resorption of the coating was systematically present in these bone remodeling areas. The average thickness of the coating was respectively 10.8, 50.2 and 151.2 microns in the proximal, mid- and distal thirds of the implant. Formation of new bone was often coupled with resorption. No debris from the coating was found in the joint tissues or in the articulating surface of the polyethylene insert. These overall histopathological features support mechanical stability of the implant and active remodelling of bone along with focal removal of HA coating associated with osteoclastic activity. No side effects from coating degradation could be demonstrated.
authors.affiliation: Department of Orthopedics and Traumatology, CHU Saint-Pierre, Brussels, Belgium.
authors.forename: D C
authors.initials: DC
authors.lastname: Hardy
authors.forename: P
authors.initials: P
authors.lastname: Frayssinet
authors.forename: P
authors.initials: P
authors.lastname: Krallis
authors.forename: P Y
authors.initials: PY
authors.lastname: Descamps
authors.forename: L
authors.initials: L
authors.lastname: Fabeck
authors.forename: J L
authors.initials: JL
authors.lastname: Delplancke
authors.forename: P E
authors.initials: PE
authors.lastname: Delince
mesh_terms: D000368:Aged; D001344:Autopsy; D016723:Bone Remodeling; D017886:Durapatite; D004867:Equipment Design; D005264:Femoral Fractures / Q000601:surgery*; D005269:Femur / Q000473:pathology*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male
chemical_list: D017886:Durapatite