title: Successful treatment of secondary acute myeloid leukemia relapsing after allogeneic bone marrow transplantation with donor lymphocyte infusion failed to prevent recurrence of primary disease: a case report.
abstract: We report a case of therapy-related secondary acute myeloid leukemia occurring in a patient during treatment for anaplastic large cell lymphoma. In spite of response to induction chemotherapy and prompt bone marrow transplantation from his matched sister, the patient experienced an early leukemia relapse within 3 months of the transplant. Treatment with oral etoposide for 3 weeks followed by donor lymphocyte infusion achieved a 7-month remission from leukemia without any further treatment. Unfortunately, the patient suffered a recurrence of the primary anaplastic large cell lymphoma that was treated by resuming chemotherapy and local radiotherapy. The patient died 20 months after DLI, still in CR for his leukemia, due to ALCL progression.
authors.affiliation: Divisione di Onco-Ematologia Pediatrica, Complesso Università-Azienda Ospedale di Padova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cesaro
authors.forename: C
authors.initials: C
authors.lastname: Messina
authors.forename: A
authors.initials: A
authors.lastname: Rosolen
authors.forename: M C
authors.initials: MC
authors.lastname: Putti
authors.forename: L
authors.initials: L
authors.lastname: Sainati
authors.forename: R
authors.initials: R
authors.lastname: Destro
authors.forename: M V
authors.initials: MV
authors.lastname: Gazzola
authors.forename: S
authors.initials: S
authors.lastname: Varotto
authors.forename: G
authors.initials: G
authors.lastname: De Silvestro
authors.forename: G
authors.initials: G
authors.lastname: Scarzello
authors.forename: M
authors.initials: M
authors.lastname: Spinelli
authors.forename: M
authors.initials: M
authors.lastname: Pillon
authors.forename: L
authors.initials: L
authors.lastname: Zanesco
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000517:prevention & control / Q000628:therapy*; D017710:Lymphocyte Transfusion; D008297:Male