Synthesis and antitumor activity of novel thioester derivatives of leinamycin.
Kanda
Y
Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Company, Ltd., Machida, Tokyo 194-8533, Japan, and Pharmaceutical Research Institute, Kyowa Hakko Kogyo Company, Ltd., Nagaizumi, Shizuoka 411-8731, Japan.
Ashizawa
T
T
Kakita
S
S
Takahashi
Y
Y
Kono
M
M
Yoshida
M
M
Saitoh
Y
Y
Okabe
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007769:Lactams; D018942:Macrolides; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012510:Sarcoma 180; D013329:Structure-Activity Relationship; D013844:Thiazoles; D013871:Thiones; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; C118757:KF 22678; D007769:Lactams; D018942:Macrolides; D011714:Pyrans; D013844:Thiazoles; D013871:Thiones; C059000:leinamycin