title: Proximal-type epithelioid sarcoma in the pelvic soft tissues.
abstract: A case of proximal-type epithelioid sarcoma arising in the pelvic soft tissues of a 46-year-old man is presented. The tumor showed a predominantly epithelioid component with rhabdoid features, cord-like arrangement, small nests, abundant eosinophilic cytoplasm containing intracytoplasmic, paranuclear, hyaline-like globules, large vesicular nuclei, and prominent nucleoli. There were foci with alveolar arrangement and a spindle-cell proliferation. The tumor cells were positive for cytokeratin CAM5.2, vimentin, epithelial membrane antigen, and CD34. Flow cytometry showed a diploid DNA content with high S-phase fraction. The patient had pelvic lymph-node metastases. He died of the disease 5 months after diagnosis. It is important to include proximal-type epithelioid sarcoma in the differential diagnosis of pelvic tumors.
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: S
authors.initials: S
authors.lastname: Ushigome
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D010386:Pelvic Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016196:S Phase; D012509:Sarcoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D004273:DNA, Neoplasm; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins