T-cell-rich B-cell non-Hodgkin's lymphoma mimicking Hodgkin's disease.
We report on a patient with recurrent T-cell-rich B-cell lymphoma (TCRBCL), initially misdiagnosed as a lymphocyte-rich Hodgkin's disease. This case exemplifies the diagnostic problems of TCRBCL and the need for immunophenotypic analysis to differentiate TCRBCL from Hodgkin's disease, nodular paragranuloma and peripheral T-cell lymphoma. A rather unusual aspect is the long disease-free interval between the excision of the node in and the late relapse in 1996. The significance of the abundant T-cell infiltration in this B-cell neoplasm will be discussed and the concepts concerning antitumor response will be reviewed. Based on epidemiological data and the clinical behaviour TCRBCL does not seem to represent a distinctive pathological entity.
Bättig
B
B
Institute of Medical Oncology, Inselspital, University of Berne, Switzerland.
Mueller-Garamvoelgyi
E
E
Cogliatti
S B
SB
Schmid
U
U
Kappeler
A
A
Cerny
T
T
Laissue
J A
JA
Fey
M F
MF
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
D015703:Antigens, CD; D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide