title: Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls.
abstract: Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium tuberculosis develop a granuloma-like lesion in which NKT cells are predominant. NKT cells play a primary role in the granulomatous response, because the latter does not occur in Jalpha281(-/-) mice, which miss NKT cells. The glycolipidic fraction of the cell walls is responsible for the recruitment of NKT cells; the recruiting activity is associated with fractions containing phosphatidylinositolmannosides. These results define a powerful experimental set up for studying the in vivo induction of NKT cell responses to microbial components.
authors.affiliation: Unité de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277, 75724 Paris Cedex 15, France.
authors.forename: I
authors.initials: I
authors.lastname: Apostolou
authors.forename: Y
authors.initials: Y
authors.lastname: Takahama
authors.forename: C
authors.initials: C
authors.lastname: Belmant
authors.forename: T
authors.initials: T
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Huerre
authors.forename: G
authors.initials: G
authors.lastname: Marchal
authors.forename: J
authors.initials: J
authors.lastname: Cui
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakauchi
authors.forename: J J
authors.initials: JJ
authors.lastname: Fournié
authors.forename: P
authors.initials: P
authors.lastname: Kourilsky
authors.forename: G
authors.initials: G
authors.lastname: Gachelin
mesh_terms: D000818:Animals; D002473:Cell Wall / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006099:Granuloma / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000648:ultrastructure; D014376:Tuberculosis / Q000276:immunology* / Q000473:pathology