title: Synthesis of enantiomerically pure (-)-(S)-brevicolline
abstract: (-)-(S)-Brevicolline (1) and related beta-carbolines were synthesized using an enantiomerically pure Michael-acceptor synthon (3). Subsequent Pictet-Spengler reaction afforded the tetrahydro-beta-carboline skeleton, which, in turn, was transformed to the beta-carboline by catalytic dehydrogenation.
authors.affiliation: Institute of Pharmacy, University of Regensburg, D-93040 Regensburg, Germany.
authors.initials: S
authors.lastname: Mahboobi
authors.initials: W
authors.lastname: Wiegrebe
authors.initials: A
authors.lastname: Popp