title: Inducibility of sustained ventricular tachycardia in a closed-chest ovine model of myocardial infarction.
abstract: The two goals of this study were (1) to develop a closed-chest animal model of monomorphic ventricular tachycardia; and (2) to investigate the effect of dual site pacing on inducibility of ventricular tachycardia. In the first part of the study, 10 of 14 sheep underwent successful induction of myocardial infarction by temporary balloon occlusion of the left anterior descending coronary artery. After a follow-up period of 21-43 days, sustained monomorphic ventricular tachycardia could be induced during programmed electrical stimulation using a "clinical" stimulation protocol in 8 of the 10 sheep. The number of ventricular tachycardia episodes per animal varied between 5 and 70. Ventricular fibrillation was never induced during programmed electrical stimulation. Ventricular tachycardia episodes lasted from 30 seconds up to 15 minutes and were terminated by antitachycardia pacing or DC cardioversion. In the second part of the study, the effect of dual site stimulation on ventricular tachycardia inducibility was investigated. High current stimuli from an area within the infarcted zone were given with the S1 programmed stimulation protocol. This dual site stimulation showed no effect on ventricular tachycardia induction during programmed electrical stimulation. This animal model shows a high induction rate of sustained monomorphic ventricular tachycardia in the chronic phase of myocardial infarction. The high incidence of ventricular tachycardia inducibility provides a reliable tool to study new techniques for the prevention of ventricular tachyarrhythmias.
authors.affiliation: Department of Medicine, University of Alabama at Birmingham, USA.
authors.forename: S
authors.initials: S
authors.lastname: Reek
authors.forename: J L
authors.initials: JL
authors.lastname: Bicknell
authors.forename: G P
authors.initials: GP
authors.lastname: Walcott
authors.forename: S P
authors.initials: SP
authors.lastname: Bishop
authors.forename: W M
authors.initials: WM
authors.lastname: Smith
authors.forename: G N
authors.initials: GN
authors.lastname: Kay
authors.forename: R E
authors.initials: RE
authors.lastname: Ideker
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D002404:Catheterization; D016009:Chi-Square Distribution; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D004554:Electric Countershock; D004558:Electric Stimulation; D004562:Electrocardiography; D005500:Follow-Up Studies; D006352:Heart Ventricles; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D011651:Pulmonary Artery; D015203:Reproducibility of Results; D012756:Sheep; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D013997:Time Factors