Characterization of learning and memory deficits in C57BL/6 mice infected with LP-BM5, a murine model of AIDS.
Mice infected with an immunosuppressive murine leukemia virus mixture, LP-BM5 show a profound immunosuppression described as murine acquired immune deficiency syndrome (AIDS). In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BM5. Spontaneous alternation behavior in a Y-maze and latent learning (spatial attention) in a water-finding test, as well as spatial reference and reversal learning in a water maze test, were significantly impaired in the mice infected with LP-BM5. These deficits appeared in the absence of any motoric and visual impairment as assessed by open-field, rotarod and visual water maze tests. These results suggest that cognitive functions are impaired in the mice infected with LP-BM5. Furthermore, LP-BM5-infected mice may be useful as a model for the AIDS dementia complex.
Iida
R
R
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
Yamada
K
K
Mamiya
T
T
Saito
K
K
Seishima
M
M
Nabeshima
T
T
D015526:AIDS Dementia Complex / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D001288:Attention / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D002455:Cell Division / Q000276:immunology; D003072:Cognition Disorders / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D004195:Disease Models, Animal; D007165:Immunosuppression Therapy; D009052:Leukemia Virus, Murine; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D008570:Memory, Short-Term / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009068:Movement / Q000502:physiology; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*