High prevalence of factor V Leiden in healthy Jordanian Arabs.
The prevalence of APC resistance in healthy Jordanian Arabs was studied. Between October 1996 through September 1997 a total of 400 healthy subjects were studied. There were 212 males and 188 females. APC resistance was studied by functional and DNA methods. There were a total of 52 subjects (13%) who were APC resistant by the functional test. There were 49 subjects (12.25%) who had FV Q506 by DNA test. Of these there were 42 heterozygous and 7 homozygous (allele frequency 0.07). None of the subjects had clinical thrombosis. It is concluded that the prevalence of APC resistance due to FV Q506 is high in Jordanian Arabs.
Awidi
A
A
Department of Medicine, Faculty of Medicine, Jordan University, Amman.
Shannak
M
M
Bseiso
A
A
Kailani
M A
MA
Kailani
M A
MA
Omar
N
N
Anshasi
B
B
Sakarneh
N
N
D020016:Activated Protein C Resistance / Q000453:epidemiology* / Q000208:ethnology*; D018912:Arabs / Q000235:genetics / Q000706:statistics & numerical data; D004247:DNA / Q000302:isolation & purification; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008297:Male; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D015995:Prevalence; D017422:Sequence Analysis, DNA
C095381:factor V Leiden; D005165:Factor V; D004247:DNA