[Chronic diarrhea due to lymphocytic colitis treated with piroxicam beta cyclodextrin].
BACKGROUND
Lymphocytic colitis is a chronic diarrhea syndrome with no endoscopically detectable anomaly and histological colonic lesions.


METHODS
A 52-year-old woman was hospitalized for chronic diarrhea. She experienced 10 to 30 liquid bowel movements per day. Symptoms had begun 8 days after taking piroxicam fl-cyclodextrin. Intraepithelial cell counts on rectum and colon endoscopic biopsies showed more than 20% lymphocytes, giving the diagnosis of lymphocytic colitis. The patient was given 5ASA 3 g/24 h. Symptoms regressed in less than one week.


CONCLUSIONS
Lymphocytic colitis is uncommon. The cause remains unknown but a secondary autoimmune mechanism triggered by drugs has been suggested. This case would implicate nonsteroidal antiinflammatory drugs. Certain authors have demonstrated that they can be involved in the development of collagen colitis.
Mennecier
D
D
Service de Pathologie Digestive, Hôpital d'Instruction des Armées Bégin, St-Mandé. omega@club-internet.fr
Gros
P
P
Bronstein
J A
JA
Thiolet
C
C
Farret
O
O
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D003092:Colitis / Q000188:drug therapy*; D003505:Cyclodextrins / Q000009:adverse effects / Q000627:therapeutic use*; D003967:Diarrhea / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008218:Lymphocytosis / Q000188:drug therapy; D008875:Middle Aged; D010894:Piroxicam / Q000009:adverse effects / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D010894:Piroxicam