title: N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.
abstract: Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.
authors.affiliation: The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Connolly
authors.forename: S K
authors.initials: SK
authors.lastname: Wetter
authors.forename: K N
authors.initials: KN
authors.lastname: Beers
authors.forename: S C
authors.initials: SC
authors.lastname: Hamel
authors.forename: R H
authors.initials: RH
authors.lastname: Chen
authors.forename: M P
authors.initials: MP
authors.lastname: Wachter
authors.forename: J
authors.initials: J
authors.lastname: Ansell
authors.forename: M M
authors.initials: MM
authors.lastname: Singer
authors.forename: M
authors.initials: M
authors.lastname: Steber
authors.forename: D M
authors.initials: DM
authors.lastname: Ritchie
authors.forename: D C
authors.initials: DC
authors.lastname: Argentieri
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004285:Dogs; D006877:Hydroxamic Acids / Q000737:chemistry / Q000494:pharmacology*; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D006877:Hydroxamic Acids; D016859:Lipoxygenase Inhibitors; C096921:atreleuton; D006918:Hydroxyurea