Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome.
OBJECTIVE
We report on a case of extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome.


RESULTS
The patient was a 33-year-old man. A transrectal prostate biopsy suggested combined germ cell tumor (yolk sac tumor + teratoma). Because there was no tumor except from the prostate, we considered this case to be a primary extragonadal germ cell tumor of the prostate. The prostate tumor responded to systemic chemotherapy with cisplatin, vinblastine and bleomycin and elevated lactate dehydrogenase and alpha-fetoprotein levels normalized. In addition to chemotherapy, the patient also underwent radiation therapy.


CONCLUSIONS
The patient has survived for approximately 4 years since the diagnosis.
Namiki
K
K
Department of Urology, Tokyo Medical University, Japan. k-namiki@tokyo-med.ac.jp
Tsuchiya
A
A
Noda
K
K
Oyama
H
H
Ishibashi
K
K
Kusama
H
H
Furusato
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D018237:Germinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000473:pathology*; D008297:Male; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin