title: Actions of calcitonin gene-related peptide on a population of submandibular ganglion cells.
abstract: In this study, we analyzed the effect of alpha-calcitonin gene-related peptide (CGRP) on the neurons of hamster submandibular ganglion (SMG). CGRP induced a small slow-depolarization accompanied with an increase in input resistance in about 60% of tested cells. CGRP enhanced durations of their Ca2+ spikes. The Ca2+ spikes were subdivided into two subgroups according to duration short duration within 1 sec and long duration of more than 1 sec. Forskolin, an activator of adenylate cyclase, mimicked the effects of CGRP. These data indicated that the effects of CGRP on SMG cells were mediated via the intracellular cyclic AMP signalling system. The effect of CGRP on the voltage-activated Ca2+ currents was characterized by enhancement of both transient and sustained components. The enhancement was greater in the transient component than in the sustained component. The subgroups of the Ca2+ spike may indicate differences in mechanism accelerating transmitter release and may reflect distinct functional roles of two different populations of SMG cells.
authors.affiliation: Department of Physiology, Tokyo Dental College, Chiba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Endoh
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects; D020013:Calcium Signaling / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology; D006224:Cricetinae; D000242:Cyclic AMP / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009333:Neck / Q000294:innervation; D018408:Patch-Clamp Techniques; D013363:Submandibular Gland / Q000187:drug effects / Q000294:innervation*
chemical_list: D015220:Calcium Channels; D005576:Colforsin; D000242:Cyclic AMP; D015740:Calcitonin Gene-Related Peptide