Effect of itraconazole on the pharmacokinetics of digoxin in guinea pigs.
The effect of itraconazole (ITZ) on the pharmacokinetics of digoxin (DGX) was investigated in guinea pigs. The plasma concentrations of DGX in guinea pigs following treatment with ITZ (20 mg/kg intraperitoneally (i.p.)) after intravenous (i.v.) administration of DGX (0.125 mg/kg) were significantly higher than in the controls. The percentage cumulative excretion (6.9%) of DGX in bile of the ITZ-treated group up to 6 h after administration of DGX was significantly reduced (p < 0.05) compared with 10.5% in the control. The percentage cumulative excretion (3.1%) of DGX in urine of the ITZ-treated group up to 6 h after administration was also one third that in the controls. The total, biliary, renal and metabolic clearances for DGX in the ITZ-treated group were significantly reduced, while the V(dss) was unaffected. The plasma unbound fraction of DGX (ranged 47-58%) in the ITZ-treated group was generally similar to that in the controls (50-57%). The blood-to-plasma concentration ratio of DGX (range 1.28-1.42) in the absence of ITZ did not change in the presence of ITZ. Based on these results, the pharmacokinetic interaction between DGX and ITZ may be due not only to a reduction in the renal clearance but also to a reduction in the metabolic clearance of DGX by ITZ.
Nishihara
K
K
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Japan.
Hibino
J
J
Kotaki
H
H
Sawada
Y
Y
Iga
T
T
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001659:Biliary Tract / Q000187:drug effects / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002316:Cardiotonic Agents / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D065607:Cytochrome P-450 Enzyme Inhibitors; D004077:Digoxin / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine; D004347:Drug Interactions; D006168:Guinea Pigs; D017964:Itraconazole / Q000494:pharmacology*; D008297:Male
D000935:Antifungal Agents; D001798:Blood Proteins; D002316:Cardiotonic Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D017964:Itraconazole; D004077:Digoxin