title: [Creutzfeldt-Jakob disease: diagnostic value of protein 14-3-3 and neuronal specific enolase assay in cerebrospinal fluid].
abstract: We studied the diagnostic value of detecting protein 14-3-3 and of assaying neuronal specific enolase (NSE) in the cerebrospinal fluid of 150 patients with suspected sporadic Creutzfeldt-Jakob disease registered in an epidemiology research program between 1991 and 1996. Sensitivity and specificity of these two tests were high. This study confirms results reported earlier and authorizes a new definition of Creutzfeldt-Jakob disease which gives protein 14-3-3 the same diagnostic value as EEG recordings for classifying sporadic cases.
authors.affiliation: INSERM Unité 360, Hôpital de la Salpêtrière, Paris.
authors.forename: J P
authors.initials: JP
authors.lastname: Brandel
authors.forename: P
authors.initials: P
authors.lastname: Beaudry
authors.forename: N
authors.initials: N
authors.lastname: Delasnerie-Lauprêtre
authors.forename: J L
authors.initials: JL
authors.lastname: Laplanche
mesh_terms: D048948:14-3-3 Proteins; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology*; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000175:diagnosis; D006801:Humans; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D011237:Predictive Value of Tests; D011506:Proteins / Q000032:analysis*; D012189:Retrospective Studies; D014446:Tyrosine 3-Monooxygenase
chemical_list: D048948:14-3-3 Proteins; D002556:Cerebrospinal Fluid Proteins; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase; D010751:Phosphopyruvate Hydratase