Double blind randomized comparative evaluation of nimesulide and paracetamol as antipyretics.
OBJECTIVE
To compare the efficacy and safety of nimesulide and paracetamol as antipyretic agents.


METHODS
Double blind, randomized clinical trial.


METHODS
Hospitalized patients having fever due to a variety of infections were given either drug in a randomized manner. (Nimesulide group = 49, Paracetamol group = 50). Serial axillary temperature was recorded after drug administration and side effects monitored.


RESULTS
The mean temperature after one hour of drug administration was significantly lower in nimesulide group (p < 0.05). Significantly fewer doses of nimesulide were required to bring down the temperature on the first day (p < 0.001). The mean maximum temperature recorded on second and third day was significantly lower in the nimesulide group (p < 0.05). Adverse reactions were seen in the form of epigastric pain and vomiting in one patient in Nimesulide group and three in paracetamol group.


CONCLUSIONS
Nimesulide is more effective than paracetamol as an antipyretic agent and is safe for use in infants and children.
Goyal
P K
PK
Department of Pediatrics, Kalawati Saran Children's Hospital, New Delhi.
Chandra
J
J
Unnikrishnan
G
G
Kumari
S
S
Passah
S M
SM
D015746:Abdominal Pain / Q000139:chemically induced; D000082:Acetaminophen / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001365:Axilla; D001831:Body Temperature / Q000187:drug effects; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013449:Sulfonamides / Q000627:therapeutic use*; D014839:Vomiting / Q000139:chemically induced
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D000082:Acetaminophen; C012655:nimesulide