Reciprocal effect of optical isomerism of EW-dipeptides on immune response.
Dipeptides of the EW-sequence, consisting of D-amino acids, were shown to inhibit spleen colony formation both after in vitro treatment of bone marrow and after the peptide injection to the donor 2-48 h prior to bone marrow taking. The inhibiting effect of D-(EW) peptides can be eliminated by injection of thymic cells to the recipient. L-(EW) peptides have no influence on colony forming activity of intact bone marrow cells but stimulate regeneration of colony formation by irradiated (1 Gy) bone marrow. Unlike L-(EW), the D-(EW) peptides suppress the development of hemopoietic stem cells into the S-phase. Supposedly, D-(EW) represent a new generation of immunoactive peptides possessing of inhibiting activity.
Deigin
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Peptide Engineering Centre PEPTOS, Miklukho-Maklaya, Moscow, Russian Federation. immunotech@ica.net
Poverenny
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AM
Semina
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OV
Semenets
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TN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D004151:Dipeptides; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D013237:Stereoisomerism
D000276:Adjuvants, Immunologic; D000889:Anti-Arrhythmia Agents; D004151:Dipeptides; D010455:Peptides; C060736:thymogen