title: Basophil releasability in young highly trained and older athletes.
abstract: OBJECTIVE
  Exercise-induced hypoxemia in highly trained athletes is associated with an increase in histamine release during exercise. The cells most implicated in blood histamine release are basophils. The aim of this study was to determine whether high-level endurance training induces modifications in histamine releasability from human basophils.
  
  
  METHODS
  Seven young highly trained athletes (YA) [aged 26.1+/-1.3 yr (mean +/- SEM)] and seven master athletes (MA) (64.4+/-4.1 yr), all known to develop exercise-induced hypoxemia, were respectively compared with seven young untrained men (YC) (23.0+/-1.5 yr) and seven older untrained men (OC) (61.6+/-1.3 yr). During an incremental exhaustive exercise, blood samples for measurement of anti-IgE-induced histamine release from leukocytes were drawn at rest, VO2max, and recovery.
  
  
  RESULTS
  Basophils from "leukocyte-rich" supernatant in YA and MA showed significantly higher histamine release induced by anti-IgE (1 microg x mL(-1) than, respectively, YC (P<0.01) and OC (P<0.05) at rest, VO2ax (P<0.01), and recovery (P<0.01). Basophils in YA and MA also showed a histamine release induced by anti-IgE that was higher at VO2max than at rest (respectively. P<0.01 and P<0.05), but this change was not found in the control groups.
  
  
  CONCLUSIONS
  In conclusion, the basophils in highly trained endurance athletes, both young and older, showed higher anti-IgE-induced histamine release than those of untrained men. This effect of high-level training seemed to be potentiated by exercise.
authors.affiliation: Laboratoire de Physiologie des Interactions, Hôpital A. de Villeneuve, Montpellier, France. physiomontp@hol.fr
authors.forename: P
authors.initials: P
authors.lastname: Mucci
authors.forename: F
authors.initials: F
authors.lastname: Anselme-Poujol
authors.forename: C
authors.initials: C
authors.lastname: Caillaud
authors.forename: I
authors.initials: I
authors.lastname: Couret
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Préfaut
mesh_terms: D000328:Adult; D000368:Aged; D001491:Basophils / Q000378:metabolism*; D005080:Exercise Test; D006632:Histamine / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D011446:Prospective Studies; D013177:Sports / Q000502:physiology*
chemical_list: D006632:Histamine