title: N-acetyltransferase 1 genetic polymorphism influences the risk of prostate cancer development.
abstract: The potential involvement of N-acetyltransferase 1 (NAT1) genetic polymorphisms in prostate cancer (PCa) patients was analyzed in 101 patients with PCa and 97 controls with no incidental malignancy. Identification of NAT1*10, the variant allele associated with the rapid acetylator phenotype was by allele-specific polymerase chain reaction (PCR). When the NAT1*10 heterozygote and other genotypes without NAT1*10 allele were considered as low risk genotypes, NAT1*10/NAT1*10 had a significantly higher risk of PCa (OR = 2.4, 95% CI; 1.0-5.6). If our preliminary results can be confirmed in a larger population, it may be a useful marker for PCa risk.
authors.affiliation: Department of Pathology, Mie University School of Medicine, Tsu, Japan. tome@doc.medic.mie-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Fukutome
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Uemura
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: J
authors.initials: J
authors.lastname: Kawamura
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: R
authors.initials: R
authors.lastname: Yatani
mesh_terms: D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000235:genetics*; D012306:Risk; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D007527:Isoenzymes; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1