Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds.
Isoxazoline containing RGD mimetics were rapidly synthesized on a solid phase to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alphavbeta3 antagonists.
Rockwell
A L
AL
Du Pont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
Rafalski
M
M
Pitts
W J
WJ
Batt
D G
DG
Petraitis
J J
JJ
DeGrado
W F
WF
Mousa
S
S
Jadhav
P K
PK
D007555:Isoxazoles / Q000737:chemistry*; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*
D007555:Isoxazoles; D009842:Oligopeptides; D019030:Receptors, Vitronectin; C047981:arginyl-glycyl-aspartic acid