title: Age-related decrease in the overall extent of perikaryal projections in rabbit spinal ganglion neurons.
abstract: The overall extent of the perikaryal projections of sensory neurons from spinal ganglia of young adult and aged rabbits was estimated by a stereological method using the electron microscope. The extent of perikaryal projections was significantly smaller in the aged animals. This age-related decrease did not seem to depend on factors intrinsic to the neuron, but on the absence of a satellite cell covering over extensive portions of the nerve cell body surface. This decrease may influence the organization of the subplasmalemmal cytoskeleton, metabolic exchange between the nerve cell body and its environment and perhaps also neuronal metabolism.
authors.affiliation: Institute of Histology, Embryology and Neurocytology, University of Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pannese
authors.forename: P
authors.initials: P
authors.lastname: Sartori
authors.forename: C
authors.initials: C
authors.lastname: Martinelli
authors.forename: M
authors.initials: M
authors.lastname: Ledda
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005727:Ganglia, Spinal / Q000254:growth & development / Q000502:physiology*; D008297:Male; D008854:Microscopy, Electron; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D011817:Rabbits