title: Factors influencing the development of hemolytic uremic syndrome caused by enterohemorrhagic Escherichia coli infection: from a questionnaire survey to in vitro experiment.
abstract: Enterohemorrhagic Escherichia coli (EHEC) is known as an etiological agent of not only hemorrhagic colitis, but also hemolytic uremic syndrome (HUS) and other serious complications. In this paper, a summary of the results, especially in relation to possible factors involving HUS complication, of a questionnaire survey conducted on the occasion of the massive EHEC outbreak in Sakai city in 1996, is presented. A brief review of the virulence factors and pathogenic mechanism involved in the development of HUS in EHEC infection is also described.
authors.affiliation: Department of Bacterial Infections, Osaka University, Japan. honda@biken.osaka-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Honda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001427:Bacterial Toxins / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000453:epidemiology*; D019453:Escherichia coli O157 / Q000472:pathogenicity*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000453:epidemiology*; D006306:Health Surveys; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D014774:Virulence
chemical_list: D001427:Bacterial Toxins