title: HIV combination therapy: immune restitution causing cryptococcal lymphadenitis dramatically improved by anti-inflammatory therapy.
abstract: Two patients with AIDS developed microscopically verified focal cryptococcal lymphadenitis while treated with highly active anti-retroviral therapy for 8 and 15 months. Both were treated with fluconazole as a secondary prophylaxis for prior cryptococcal meningitis. Cryptococcus neoformans did not grow. Amphotericin was ineffective. Anti-inflammatory drugs had a dramatic effect.
authors.affiliation: Service de Médecine Interne 2, Hôpital Cochin, Université René Descartes, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Blanche
authors.forename: B
authors.initials: B
authors.lastname: Gombert
authors.forename: C
authors.initials: C
authors.lastname: Ginsburg
authors.forename: A
authors.initials: A
authors.lastname: Passeron
authors.forename: I
authors.initials: I
authors.lastname: Stubei
authors.forename: A
authors.initials: A
authors.lastname: Rigolet
authors.forename: D
authors.initials: D
authors.lastname: Salmon
authors.forename: D
authors.initials: D
authors.lastname: Sicard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy / Q000209:etiology*; D015725:Fluconazole / Q000627:therapeutic use; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008199:Lymphadenitis / Q000188:drug therapy / Q000209:etiology*; D008297:Male
chemical_list: D000893:Anti-Inflammatory Agents; D017320:HIV Protease Inhibitors; D015725:Fluconazole