title: A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation.
abstract: We report the case of a 32-year-old patient with ALL who developed autoimmune thrombocytopenia 2 months following allogeneic bone marrow transplantation. An IgM autoantibody against the platelet glycoprotein Ib/IX complex was observed. Treatment with high-dose steroids and intravenous immunoglobulin G failed to produce any benefit and the thrombocytopenia led to fatal gastrointestinal haemorrhage. The possible factors contributing to post-allograft thrombocytopenia and potential management strategies are discussed.
authors.affiliation: Department of Haematology, University College London Hospitals, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Kottaridis
authors.forename: H
authors.initials: H
authors.lastname: Rees
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: S F
authors.initials: SF
authors.lastname: Garner
authors.forename: A R
authors.initials: AR
authors.lastname: Perry
authors.forename: A J
authors.initials: AJ
authors.lastname: Peniket
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
authors.forename: S
authors.initials: S
authors.lastname: Mackinnon
authors.forename: W H
authors.initials: WH
authors.lastname: Ouwehand
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology*; D014019:Tissue Donors
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D019038:Platelet Glycoprotein GPIb-IX Complex