title: Paroxysmal cold haemoglobinuria caused by non-Hodgkin's lymphoma.
abstract: Paroxysmal cold haemoglobinuria is an autoimmune haemolytic anaemia characterized by a biphasic polyclonal IgG autoantibody, the Donath-Landsteiner (D-L) antibody. Although classically described in association with chronic syphilis, it is most commonly seen after acute viral infections in children. We describe a case of high-grade B-cell non-Hodgkin's lymphoma which presented with paroxysmal cold haemoglobinuria. The lymphoma responded promptly to combination chemotherapy whilst, at the same time, the haemolytic process rapidly resolved. Subsequent investigations showed that the D-L antibody originated from the lymphoma cells.
authors.affiliation: Department of Haematology, Leicester Royal Infirmary, UK.
authors.forename: M
authors.initials: M
authors.lastname: Sivakumaran
authors.forename: P T
authors.initials: PT
authors.lastname: Murphy
authors.forename: D J
authors.initials: DJ
authors.lastname: Booker
authors.forename: J K
authors.initials: JK
authors.lastname: Wood
authors.forename: R
authors.initials: R
authors.lastname: Stamps
authors.forename: R J
authors.initials: RJ
authors.lastname: Sokol
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D003080:Cold Temperature; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy; D008297:Male
chemical_list: D001323:Autoantibodies