The transduction of very small hydrostatic pressures.
This paper reviews experiments in which cells, subjected to hydrostatic pressures of 20 kPa or less, (micro-pressures), demonstrate a perturbation in growth and or metabolism. Similarly, the behavioural responses of aquatic animals (lacking an obvious compressible gas phase) to comparable pressures are reviewed. It may be shown that in both cases the effect of such very low hydrostatic pressures cannot be mediated through the thermodynamic mechanisms which are invoked for the effects of high hydrostatic pressure. The general conclusion is that cells probably respond to micro-pressures through a mechanical process. Differential compression of cellular structures is likely to cause shear and strain, leading to changes in enzyme and/or ion channel activity. If this conclusion is true then it raises a novel question about the involvement of 'micro-mechanical' effects in cells subjected to high hydrostatic pressure. The responses of aquatic animals to micro-pressures may be accounted for, using the model case of the crab, by the mechanical, bulk, compression of hair cells in the statocysts, the organ of balance. If this is true, it raises the interesting question of why the putative cellular mechanisms of micro-pressure transduction appear to have been superseded by the statocyst.
Macdonald
A G
AG
Department of Biomedical Sciences, University of Aberdeen, Scotland, UK. a.macdonald@abdn.ac.uk
Fraser
P J
PJ
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D003386:Brachyura / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology*; D006874:Hydrostatic Pressure; D008465:Mechanoreceptors / Q000502:physiology*