title: High numbers of clonal CD19+ cells in the peripheral blood of a patient with multiple myeloma.
abstract: Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of late-stage B cells or pre-plasma cells were present in the peripheral blood (PB) of a patient with MM. During treatment the initial high level of PB clonal cells was markedly reduced and remained low (<1%) post transplant, even after disease progression. In addition, we found that the MM clone did not include a B-progenitor population defined by CD34.
authors.affiliation: Department of Haematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thomas.r@inet.uni2.dk
authors.forename: T
authors.initials: T
authors.lastname: Rasmussen
authors.forename: J
authors.initials: J
authors.lastname: Kastrup
authors.forename: L M
authors.initials: LM
authors.lastname: Knudsen
authors.forename: H E
authors.initials: HE
authors.lastname: Johnsen
mesh_terms: D018941:Antigens, CD19 / Q000378:metabolism*; D001402:B-Lymphocytes / Q000473:pathology*; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D018941:Antigens, CD19; D007143:Immunoglobulin Heavy Chains