The influence of exogenous antioxidants and physical exercise on some parameters associated with production and removal of free radicals.
Metabolic processes generate chemically active forms of oxygen, among which a prominent role is played by the superoxide ion. Cells are equipped with defence systems against the effects of superoxide radicals, superoxide dismutase is the most important one. The organism depends on the delivery of exogenous antioxidants, like selenium, vitamins E and C. Physical exercise triggers the production of superoxide radicals, which can at least partly be responsible for muscular damage. This work has studied the effect of Protection Zellaktiv (Smith Kline Beecham, Fink Naturarznei GmbH), a preparation containing selenium, vitamins C, E, B2, niacin and beta-carotene on the activities of superoxide dismutase and catalase, levels of glutathione malondialdehyde selenium, iron, zinc, triglicerides, total cholesterol, HDL- and LDL-cholesterol, before and after physical exercise. Muscle status was monitored by the activities of lactic dehydrogenase and creatine kinase. Protecton Zellaktiv was administered orally for one month, the measurements were repeated and the results before and after treatment were compared. It was found that treatment diminished the levels of malondialdehyde and zinc in serum, as well as cholesterol and triglicerides. Physical exercise before treatment decreased the levels of reduced glutatione, zinc and triglycerides. As expected, the levels of selenium were increased by the preparation. Protecton Zellaktiv suppressed the production of malondialdehyde during physical exercise. The preparation had a beneficial effect on lipid levels and it is inferred that lipid peroxidation was suppressed.
Kaczmarski
M
M
Institute of Pharmacology, Pomeranian Medical University, Szczecin, Poland.
Wójcicki
J
J
Samochowiec
L
L
Dutkiewicz
T
T
Sych
Z
Z
D000328:Adult; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D004338:Drug Combinations; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D014815:Vitamins / Q000378:metabolism / Q000494:pharmacology*
D000975:Antioxidants; D004338:Drug Combinations; D005609:Free Radicals; C119607:Protecton Zellaktiv; D014815:Vitamins; D012643:Selenium