Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development.
The TNF-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL or ODF) has been identified as the osteoclast differentiation factor and a regulator of T cell-dendritic cell interactions in the immune system. Surprisingly, the same molecule was identified as a crucial factor in early lymphocyte development and lymph node organogenesis. We will discuss the role of OPGL in bone remodelling and the immune system.
Kong
Y Y
YY
Amgen Institute, Ontario Cancer Institute, Toronto, Canada.
Boyle
W J
WJ
Penninger
J M
JM
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007107:Immune System / Q000276:immunology; D008198:Lymph Nodes / Q000254:growth & development* / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism*; D010010:Osteoclasts / Q000166:cytology* / Q000378:metabolism; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology / Q000378:metabolism*
D002352:Carrier Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human