title: [Success rate of anesthesia induction using target-controlled infusion of propofol with fentanyl].
abstract: Twenty-one patients were studied to compare the success rate of anesthesia induction using target-controlled infusion of propofol with and without fentanyl. All patients were premedicated with atropine 0.5 mg and hydroxyzine 25-50 mg. Five minutes after intravenous administration of fentanyl 2 micrograms.kg-1, patients were given infusions of propofol designed to achieve target blood concentrations of 3 micrograms.kg-1. Loss of verbal contact was regarded as successful induction. The success rate of anesthesia induction within three minutes of achieving the target concentration was 90%. Pain on injection and reduction in blood pressure were infrequent. Selecting a target concentration of 3 micrograms.kg-1 with fentanyl 2 micrograms.kg-1 can be expected to successfully induce anesthesia in the majority of patients without major hemodynamic side effects and pain on injection.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, University of Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Masago
authors.forename: O
authors.initials: O
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Ogura
authors.forename: C
authors.initials: C
authors.lastname: Yajima
authors.forename: H
authors.initials: H
authors.lastname: Arita
authors.forename: K
authors.initials: K
authors.lastname: Hanaoka
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D019162:Anesthetics, Combined / Q000008:administration & dosage* / Q000097:blood; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D005283:Fentanyl; D015742:Propofol