Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection.
Gammadelta T-cell lymphoma is a rare T-cell lymphoproliferative disorder that has been reported in both immunocompetent and immunocompromised persons. This report describes a forty eight year old patient who developed gammadelta T-cell lymphoma four years after undergoing living-related kidney transplantation. The lymphoma expressed CD2, CD3, CD7, CD8 and CD56, and the gammadelta T-cell receptor and did not express CD5, CD4 and the alphabeta T-cell receptor. In addition, HHV-6 was cultured from the patient's bone marrow, marking the first time that this virus has been associated with gammadelta T-cell lymphoma. Since all patients with gammadelta T-cell lymphoma described to date have responded poorly to standard combination chemotherapies, the patient was treated with the purine analogue 2-chlorodeoxyadenosine. While he responded transiently to treatment, long term remission was not achieved indicating that additional therapeutic approches still need to be developed, for the management of this disorder.
Lin
W C
WC
Division of Oncology and Transplantation, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. lin00011@mc.duke.edu
Moore
J O
JO
Mann
K P
KP
Traweek
S T
ST
Smith
C
C
D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology / Q000821:virology; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D017338:Cladribine / Q000627:therapeutic use; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000601:surgery; D006566:Herpesviridae Infections / Q000150:complications*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000096:biosynthesis* / Q000235:genetics
D015703:Antigens, CD; D000970:Antineoplastic Agents; D016827:CD8 Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; D017338:Cladribine