[The role of selected serologic markers in the diagnosis of autoimmune hepatitis].
Autoimmune hepatitis (AIH) is a progressive inflammatory liver disease characterized by specific duration of symptoms (above 6 months), 3- to 10-fold elevation in serum aminotransferase activities, 2-fold elevation in gamma-globulin, high titers (above 1:40) of circulating autoantibodies. Antinuclear antibodies (ANA), smooth muscle antibodies (SMA), and antibodies to liver/kidney microsome type 1 (anti-LKM1) are the commonly available markers of AIH. SMA and ANA lack disease specificity and they are present commonly in different liver diseases. Anti-LKM1 usually connote a type 2 form of AIH which involves children and responds to corticosteroid therapy. Other autoantibodies, such as those against actin (SMA-AA), the liver-cytosolic antigen (anti-LC1), the liver-specific membrane lipoprotein (anti-LPS), asialoglycoprotein receptor (anti-ASGPR), have greater disease specificity but less availability.
Marcinkiewicz
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Oddziału Chorób Wewnetrznych i Gastroenterologii Wojewódzkiego Szpitala Zespolonego im.Jedrzeja Sniadeckiego w Białymstoku.
Gryc
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Kreczko
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D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D019693:Hepatitis, Autoimmune / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D000637:Transaminases / Q000097:blood; D005719:gamma-Globulins / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D015415:Biomarkers; D005719:gamma-Globulins; D000637:Transaminases