[The oxygen-transport function of the blood and cell metabolism in patients with heart failure of different origins].
OBJECTIVE
To specify formation of systemic compensatory-adaptive processes and analysis of their characteristics in cardiac failure (CF) of various genesis.


METHODS
101 patients with CF functional class II (53 patients with IHD without blood hypertension and 48 patients with blood hypertension without IHD) were examined for lactate, 2,3-diphosphate dehydrogenase (DPG), activity of lactate dehydrogenase (LDG), G-6-PDG in red cells, succinate dehydrogenase (SDG) in leukocytes. 47 patients received treatment including inhibitors of angiotensin-converting enzyme (ACEI).


RESULTS
IHD patients demonstrated after treatment drop in the levels of lactate, 2,3-DPG, LDG, SDG activation. Hypertensive patients continued with latent hypoxia (high activity of SDG, G-6-PDG, 2,3-PDG, low lactate concentration). LDG and G-6-PDG rose more in patients given ACEI.


CONCLUSIONS
At initial stages of CF blood system compensatory reactions form differently depending on the mechanism of decompensation development. This is confirmed by changes of blood oxygen-transport function and cell metabolism.
Shlyk
S V
SV
Terent'ev
V P
VP
Mikashinovich
Z I
ZI
D000328:Adult; D001692:Biological Transport; D001773:Blood Cells / Q000378:metabolism*; D006333:Heart Failure / Q000097:blood* / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010343:Patient Admission; D010351:Patient Discharge
D010100:Oxygen