Translation initiation factor 4E.
Translation initiation factor 4E (eIF4E) binds the 7-methylguanosine cap structure of mRNA and mediates recruitment of mRNA to ribosomes, with the potential of regulating the overall rate of translation and discriminating between different RNAs. Increased translation is required for progress through the cell cycle, and it is therefore not surprising that eIF4E has oncogenic properties when overexpressed. The function of this review is to summarise what is known about eIF4E gene and protein structure, biological function and medical relevance.
McKendrick
L
L
Biochemistry Laboratory, School of Biological Sciences, University of Sussex, Falmer, Brighton, UK. bdfa4@sussex.ac.uk
Pain
V M
VM
Morley
S J
SJ
D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D039561:Eukaryotic Initiation Factor-4E; D006801:Humans; D008969:Molecular Sequence Data; D010448:Peptide Initiation Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D039561:Eukaryotic Initiation Factor-4E; D010448:Peptide Initiation Factors; D012335:RNA, Ribosomal