Lavender oil inhibits immediate-type allergic reaction in mice and rats.
We studied the effects of lavender oil on mast cell-mediated immediate-type allergic reactions in mice and rats. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently mast cell-dependent ear swelling response induced by compound 48/80 in mice by both topical and intradermal application. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) inhibited concentration-dependently passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) IgE in rats by both topical and intradermal application. Lavender oil (1:500, 1:100, 1:10, 1:1, 1:0) also inhibited concentration-dependently the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, lavender oil (1:1000, 1:100, 1:10, 1:0) had a significant inhibitory effect on anti-DNP IgE-induced tumour necrosis factor-alpha secretion from peritoneal mast cells. These results indicate that lavender oil inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in-vivo and in-vitro.
Kim
H M
HM
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Cho
S H
SH
D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D004136:Dinitrobenzenes / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000009:adverse effects; D027523:Lavandula; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009822:Oils, Volatile / Q000494:pharmacology / Q000627:therapeutic use*; D010537:Peritoneum / Q000166:cytology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010938:Plant Oils; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012871:Skin Diseases / Q000209:etiology / Q000517:prevention & control; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000009:adverse effects
D004136:Dinitrobenzenes; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; C045718:lavender oil