title: In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs.
abstract: Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Hacettepe University School of Medicine, 06100 Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Akova
authors.forename: D
authors.initials: D
authors.lastname: Gür
authors.forename: D M
authors.initials: DM
authors.lastname: Livermore
authors.forename: T
authors.initials: T
authors.lastname: Kocagöz
authors.forename: H E
authors.initials: HE
authors.lastname: Akalin
mesh_terms: D017963:Azithromycin / Q000494:pharmacology*; D017347:Brucella melitensis / Q000187:drug effects* / Q000378:metabolism; D004318:Doxycycline / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D015363:Quinolones / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*
chemical_list: D015363:Quinolones; D017963:Azithromycin; D004318:Doxycycline; D012293:Rifampin; D013307:Streptomycin