[Adamantane derivatives enhancing body's resistance to emergencies].
A total of 329 novel adamantane derivatives have been synthesized and pharmacologically studied. Among them, the compounds containing halogen-containing aromatic radicals in the second position show the most pronounced effect on animal resistance to the emergencies induced by its habitat and performance. N-(2-adamantyl)-N-(para-bromphenyl)amine (bromantane) possesses a low toxicity, a high ability to enhance the physical and operant working maintenance of animals, to accelerate its recovery in developed fatigue, in hyperthermia and hypoxia in particular. 2-(para-chlorobenzoylamine)adamantane (chlodantane) has the processes of a rapid-action adaptogenic agent by enhancing the resistance of animals to various physical and toxically chemical noxious agents. The two compounds have immunostimulating effects in secondary stress-induced immunodeficiencies whose mechanism of action is a membranous protective activity.
Morozov
I S
IS
Klimova
N V
NV
Sergeeva
S A
SA
Ivanova
I A
IA
Barchukov
V G
VG
Kovalev
G I
GI
Piatin
B M
BM
Avdiunina
N I
NI
D000218:Adamantane / Q000031:analogs & derivatives*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005790:General Adaptation Syndrome / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy
D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane; D000218:Adamantane