A new device for selective removal of CD4+ T cells.
To control antigen (Ag)-specific immune cells is important in the treatment of autoimmune diseases. In particular, a direct solution may be obtained by controlling the CD4+ cell function that controls the immune response of autoimmune T cells. Thus, a technique to selectively remove CD4+ cells has been developed, based on the consideration that the immune system may possibly be modified by selectively removing the CD4+ cells by means of extracorporeal circulation. The currently developed device to selectively remove CD4+ cells uses a material made of nonwoven fabric with monoclonal antibodies immobilized on the surface. With this device, removal of only CD4+ cells from human mononuclear cells suspension can be accomplished. Moreover, CD4+ cells can be specifically removed from peripheral whole blood by direct perfusion. This review outlines a series of procedures for selective cell removal and the results of our research.
Onodera
H
H
Abe
Y
Y
Yoshida
M
M
Yamawaki
N
N
Yamashita
Y
Y
Matsuo
H
H
Ichinose
K
K
Otsuru
I
I
Shibuya
N
N
D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D004195:Disease Models, Animal; D004867:Equipment Design; D006801:Humans; D051381:Rats