Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists.
We studied the structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this study.
Lee
I S
IS
Biotechnology Research Division, Korea Research Institute of Bioscience and Biotechnology, Taejon.
Jung
K Y
KY
Oh
S R
SR
Park
S H
SH
Ahn
K S
KS
Lee
H K
HK
D001713:Biphenyl Compounds / Q000737:chemistry; D034242:Cyclooctanes; D004951:Esterification; D006900:Hydroxylation; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001713:Biphenyl Compounds; D034242:Cyclooctanes; D017705:Lignans; D010972:Platelet Activating Factor; D011083:Polycyclic Compounds; C015499:schizandrin B; C011105:schizandrin