Enhancing the inhibitory effect of nicotinamide upon collagen II induced arthritis in mice using N-acetylcysteine.
We could show that both nicotinamide and N-acetylcysteine inhibit collagen induced arthritis in mice. In the present paper, using lower doses of each, we applied combinations of these two substances. We were able to confirm potentiating effects of these combinations. These results may allow new perspectives for the therapy of arthritis to emerge.
Kröger
H
H
Deutsches Rheumaforschungszentrum Berlin (DRIZ).
Hauschild
A
A
Ohde
M
M
Bache
K
K
Voigt
W P
WP
Ehrlich
W
W
D000111:Acetylcysteine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001168:Arthritis / Q000139:chemically induced* / Q000188:drug therapy; D002678:Chimera; D003094:Collagen / Q000037:antagonists & inhibitors*; D003433:Crosses, Genetic; D051379:Mice; D008811:Mice, Inbred DBA; D009536:Niacinamide / Q000819:agonists* / Q000494:pharmacology / Q000627:therapeutic use
D009536:Niacinamide; D003094:Collagen; D000111:Acetylcysteine