title: Plasma homocysteine concentration in a Belgian school-age population.
abstract: BACKGROUND
  Total plasma homocysteine (tHcy) is an independent risk factor for cardiovascular disease in adults. Data for children and adolescents are lacking.
  
  
  OBJECTIVE
  The aim of this study was to provide a reference range for tHcy and to explore the relation between tHcy and nutritional indexes in a Belgian pediatric population.
  
  
  METHODS
  tHcy, folate, and vitamin B-12 were measured in 647 healthy children (353 girls and 294 boys) aged 5-19 y.
  
  
  RESULTS
  The tHcy distribution was, as in adults, skewed to the right [geometric mean (-1 SD, +1 SD): 7.41 micromol/L (5.51, 9.96)]. Concentrations were lowest in younger children and increased with age. After the tHcy distribution was examined according to age, 3 age ranges were distinguished: 5-9 y [6.21 micromol/L (5.14, 7.50)], 10-14 y [7.09 micromol/L (5.69, 8.84)], and 15-19 y [8.84 micromol/L (6.36, 12.29)]. We observed no significant differences in tHcy values between girls and boys in children aged < 15 y; in postpubertal children, however, concentrations were higher in boys than in girls. In the 3 age groups, folate was inversely correlated with tHcy; the negative relation between tHcy and vitamin B-12 was less strong. Familial cardiovascular disease was more frequent in children who had hyperhomocysteinemia.
  
  
  CONCLUSIONS
  These observations suggest that in children, as in adults, genetic, nutritional, and endocrine factors are determinants of the metabolism of homocysteine. The significance of tHcy values in childhood and young adulthood in terms of predicting cardiovascular risk in adulthood should be investigated.
authors.affiliation: Laboratory of Pediatrics, University Children's Hospital Queen Fabiola, Brussels, Belgium. pbourdou@resulb.ulb.ac.be
authors.forename: C
authors.initials: C
authors.lastname: De Laet
authors.forename: J C
authors.initials: JC
authors.lastname: Wautrecht
authors.forename: D
authors.initials: D
authors.lastname: Brasseur
authors.forename: M
authors.initials: M
authors.lastname: Dramaix
authors.forename: J M
authors.initials: JM
authors.lastname: Boeynaems
authors.forename: J
authors.initials: J
authors.lastname: Decuyper
authors.forename: A
authors.initials: A
authors.lastname: Kahn
mesh_terms: D000293:Adolescent; D001530:Belgium; D002648:Child; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D011627:Puberty; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12