The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity.
The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.
Cardona
P J
PJ
Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Catalonia, Spain.
Cooper
A
A
Luquín
M
M
Ariza
A
A
Filipo
F
F
Orme
I M
IM
Ausina
V
V
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000209:etiology / Q000276:immunology / Q000473:pathology; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D012333:RNA, Messenger / Q000096:biosynthesis; D014397:Tuberculosis, Pulmonary / Q000209:etiology* / Q000276:immunology* / Q000473:pathology
D000336:Aerosols; D016207:Cytokines; D012333:RNA, Messenger