The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.
The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons.
Schröder
U H
UH
Project Group Neuropharmacology, Leibniz Institute for Neurobiology, Magdeburg, Germany. schroede@ifn-magdeburg.de
Breder
J
J
Sabelhaus
C F
CF
Reymann
K G
KG
D000818:Animals; D015687:Cell Hypoxia; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007003:Hypoglycemia; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D019831:Sodium-Calcium Exchanger / Q000037:antagonists & inhibitors*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
C101670:2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate; D018696:Neuroprotective Agents; D019831:Sodium-Calcium Exchanger; D013890:Thiourea