[Hyperplasia of sebaceous glands (Fordyce's disease) in an oral mucocutaneous graft: 45-year follow-up].
BACKGROUND
Diffuse sebaceous gland hyperplasia in transplanted buccal mucosa is a very rare condition. We report on a further patient with this entity.


METHODS
In 1953, a now 68-year-old man suffered a severe alkali burn. Transplantation of oral mucosa was performed that same day in order to prevent perforation of the eye. Over the following 45 years, the patient developed multiple yellowish nodules within the grafts. Histologically, these nodules proved to be normally differentiated sebaceous glands.


CONCLUSIONS
Diffuse sebaceous gland hyperplasia originating from within oral mucosa and developing over an extended period of time is a clinical entity known as Fordyce's disease. It is this a late complication of mucocutaneous transplantation, and although it constitutes mainly a problem of cosmesis, functionally it can lead to aberrant secretion of sebum.
Landenberger
H
H
Abteilung I (Allgemeine Augenheilkunde mit Poliklinik), Universitäts-Augenklinik.
Siepmann
K
K
Rohrbach
J M
JM
D000368:Aged; D002057:Burns, Chemical / Q000628:therapy; D002454:Cell Differentiation; D005500:Follow-Up Studies; D005588:Fox-Fordyce Disease / Q000473:pathology*; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000637:transplantation*; D012627:Sebaceous Glands / Q000473:pathology*