Investigation of new potent KDO-8-phosphate synthetase inhibitors.
A total synthesis of (Z,E)-D-Glucophosphoenolpyruvate and its carboxylic ester derivatives is described in four or five steps from 2,3:5,6-Di-O-isopropylidene-4-O-t-butydimethylsilyl-D-glucose.
Coutrot
P
P
Laboratoire de Chimie Organique II, Institut Nancéien de Chimie Moléculaire, UHP, Nancy, Vandoeuvre-lès-Nancy, France. coutrot@incm.u-nancy.fr
Dumarçay
S
S
Finance
C
C
Tabyaoui
M
M
Tabyaoui
B
B
Grison
C
C
D000446:Aldehyde-Lyases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000201:enzymology; D008826:Microbial Sensitivity Tests
D004791:Enzyme Inhibitors; C020011:2-dehydro-3-deoxyphosphooctonate aldolase; D000446:Aldehyde-Lyases