Tubulointerstitial nephritis associated with minimal self reexposure to rifampin.
We report the case of a 27-year-old Asian man who self-medicated with two capsules of rifampin 1 year after completing a continuous course of chemotherapy for tuberculosis that included that drug. He developed flank pain and edema and presented with uremia requiring dialysis; despite this, he had a serum potassium of only 3.5 mEq/L. Renal biopsy showed interstitial infiltrate with inflammation of the tubules. Renal function began to improve after a 3-week course of prednisone. This case is remarkable for the severity of the renal failure despite such a minimal self-exposure.
Feinfeld
D A
DA
Departments of Medicine and Pathology, Nassau County Medical Center, East Meadow, NY 11554, USA. feinfeld@ncmc.edu
Ansari
N
N
Nuovo
M
M
Hussain
A
A
Mir
R
R
D000208:Acute Disease; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000473:pathology; D011188:Potassium / Q000097:blood; D011241:Prednisone / Q000627:therapeutic use; D012293:Rifampin / Q000009:adverse effects*; D012651:Self Medication; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000904:Antibiotics, Antitubercular; D011188:Potassium; D011241:Prednisone; D012293:Rifampin