Is recruitment more difficult with a placebo arm in randomised controlled trials? A quasirandomised, interview based study.
OBJECTIVE
To investigate whether including a placebo arm in a clinical trial of hormone replacement therapy influenced women's stated willingness to participate.


METHODS
Quasirandomised, interview based study.


METHODS
10 group practices in the Medical Research Council's General Practice Research Framework.


METHODS
436 postmenopausal women aged 45-64 who had not had a hysterectomy.


METHODS
Stated willingness to enter a trial and reasons for the decisions made.


RESULTS
Of 218 women told about the trial without a placebo arm, 85 (39%) indicated their willingness to enter compared with 65 (30%) of the 218 women told about the trial with the placebo arm (P=0.06). Part of this difference was due to explicit reluctance to take a placebo. Altruism and personal benefit were the reasons most frequently given for wanting to take part in a trial. The reasons most frequently cited for not wanting to take part were reluctance to restart periods, not wanting to take unknown or unnecessary tablets, or not wanting to interfere with present good health.


CONCLUSIONS
For preventive trials the inclusion of a placebo arm may reduce patients' willingness to participate.
Welton
A J
AJ
Medical Research Council Epidemiology and Medical Care Unit, Wolfson Institute of Preventive Medicine, St Bartholomew's and Royal London Hospital School of Medicine and Dentistry, London ECIM 6BQ. a.j.welton@mds.qmw.ac.uk
Vickers
M R
MR
Cooper
J A
JA
Meade
T W
TW
Marteau
T M
TM
D000465:Algorithms; D003657:Decision Making; D030881:Disclosure; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D018579:Patient Selection; D010919:Placebos; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D035842:Research Subjects; D018570:Risk Assessment
D010919:Placebos