title: [Efficacy of EMLA cream, effect of time and place of application].
abstract: OBJECTIVE
  To evaluate the anesthetic efficacy of EMLA cream for alleviating pain associated with puncture and pressure in areas where venous catheters are normally inserted.
  
  
  METHODS
  We performed a prospective, double blind study in 38 volunteers between 25 and 36 years of age, after obtaining informed consent. A 1.5 g dose of EMLA cream was applied to three sites on each patient: the back of the hand, the antecubital fossa and the side of the neck. Placebo cream with similar characteristics was applied to contralateral sites. Pain was evaluated on a visual analog scale (VAS, 0-10). Tactile sensitivity was assessed on a four-point scale (0 = no sensation; 1 = slight sensation; 2 = moderate, and 3 = strong). An analysis of variance study was performed to compare baseline scores to results over time, and placebo results to EMLA scores for each test site.
  
  
  RESULTS
  The assessment of response to puncture and pressure gradually decreased over time for the sites where EMLA cream was applied, but not for the areas where placebo was applied.
  
  
  CONCLUSIONS
  The efficacy of EMLA cream varies demonstrably depending on type of stimulus, site of application and time since application.
authors.affiliation: Servicio de Anestesiología, Hospital Virgen de las Nieves, Granada.
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Tellería
authors.forename: M E
authors.initials: ME
authors.lastname: Cano Serrano
authors.forename: J
authors.initials: J
authors.lastname: Rufino Ruiz
mesh_terms: D000328:Adult; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D004550:Elbow; D004655:Emulsions; D004890:Erythema / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006225:Hand; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009333:Neck; D009339:Needles; D009824:Ointments; D009928:Organ Specificity; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D011318:Prilocaine / Q000008:administration & dosage*; D011434:Proprioception; D011446:Prospective Studies; D011537:Pruritus / Q000209:etiology / Q000517:prevention & control; D011677:Punctures / Q000009:adverse effects / Q000295:instrumentation; D013997:Time Factors
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D004655:Emulsions; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine