Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals. Generalized spectral localization by imaging.
Quantitative magnetic resonance imaging of lactate using a zero-quantum/double-quantum filter and generalized spectral localization by imaging (GSLIM) was applied to a model of unilateral stroke in gerbil brain. GSLIM lactate images at 4T clearly reveal elevated concentrations of lactate in the ischemic compared with the normal hemisphere 100-175 minutes after unilateral carotid ligation. These results indicate that the technique is capable of studies of brain infarcts, and that application to human ischemic pathology in brain and other tissues may be possible.
Kmiecik
J A
JA
Biomedical Magnetic Resonance Laboratory, University of Illinois at Urbana-Champaign, Urbana 61801, USA.
Gregory
C D
CD
Liang
Z P
ZP
Lauterbur
P C
PC
Dawson
M J
MJ
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000175:diagnosis / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000378:metabolism; D004195:Disease Models, Animal; D005374:Filtration / Q000295:instrumentation / Q000379:methods; D005849:Gerbillinae; D019344:Lactic Acid / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male
D019344:Lactic Acid