title: Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells.
abstract: Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhibit adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metalloproteinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whereas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.
authors.affiliation: School of Food and Nutritional Sciences, University of Shizuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saeki
authors.forename: Y
authors.initials: Y
authors.lastname: Shoji
authors.forename: T
authors.initials: T
authors.lastname: Noro
authors.forename: T
authors.initials: T
authors.lastname: Miyase
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Funayama
authors.forename: M
authors.initials: M
authors.lastname: Isemura
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006601:Hexoses / Q000494:pharmacology*; D051379:Mice; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006601:Hexoses; D005707:Gallic Acid; C060475:1,2,3,6-tetragalloylglucose; D005947:Glucose; C093412:hamamelitannin