Structure and validation of a pharmacokinetic model for benzene.
A pharmacokinetic model for benzene has been developed and validated for the inhalation aspects of its operation. The validation shows reasonable agreement between the model outputs and human biological data for phenol in urine, benzene in alveolar air, and benzene in mixed exhaled air.
Sinclair
G C
GC
Occupational Hygiene Unit, Deakin University, Victoria, Australia. Georgia.Sinclair@bigpond.com
Gray
C N
CN
Sherwood
R J
RJ
D000395:Air Pollutants, Occupational / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics; D001554:Benzene / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics; D006801:Humans; D008657:Metabolic Clearance Rate; D008956:Models, Chemical; D016273:Occupational Exposure / Q000032:analysis*; D015203:Reproducibility of Results; D012869:Skin Absorption; D013997:Time Factors
D000395:Air Pollutants, Occupational; D001554:Benzene