Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida.
Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.
Sittie
A A
AA
Lemmich
E
E
Olsen
C E
CE
Hviid
L
L
Kharazmi
A
A
Nkrumah
F K
FK
Christensen
S B
SB
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D018320:Leishmania major / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000880:Anthraquinones; D000962:Antimalarials; D000981:Antiprotozoal Agents