title: Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida.
abstract: Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.
authors.forename: A A
authors.initials: AA
authors.lastname: Sittie
authors.forename: E
authors.initials: E
authors.lastname: Lemmich
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: L
authors.initials: L
authors.lastname: Hviid
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
authors.forename: F K
authors.initials: FK
authors.lastname: Nkrumah
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D018320:Leishmania major / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000880:Anthraquinones; D000962:Antimalarials; D000981:Antiprotozoal Agents