Enteropathogenic E. coli interactions with host cells.
Enteropathogenic E. coli (EPEC) interacts with intestinal epithelial cells, causing diarrhea and associated diseases. This pathogen binds to epithelial cells using sophisticated mechanisms that exploit existing epithelial signal transduction pathways and host cytoskeletal components, ultimately resulting in the bacterium resting upon a pedestal on host cell surfaces. Recent data indicates that similar mechanisms occur in vivo. EPEC interactions with host cells illustrate several principles of pathogenesis that are used by bacteria that interact with mammalian host cells.
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Biotechnology Laboratory, University of British Columbia, Vancouver, Canada.
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D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D003967:Diarrhea / Q000209:etiology; D004847:Epithelial Cells / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity* / Q000502:physiology; D004927:Escherichia coli Infections / Q000209:etiology; D029968:Escherichia coli Proteins; D006801:Humans; D007422:Intestines / Q000382:microbiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli