title: Effect of ovarian suppression on glucose metabolism of young lean women with and without ovarian hyperandrogenism.
abstract: Gonadal steroids are believed to influence glucose metabolism, oestrogens inducing an improvement and androgens or progestins a deterioration. At baseline and after 3 months of ovarian suppression with a gonadotrophin-releasing hormone analogue (GnRHa: goserelin depot 3.75 mg/28 days), glucose metabolism was evaluated in eight lean women affected by ovarian hyperandrogenism (PCOS) and six age-weight-matched non-hyperandrogenic women (controls) by using both an oral glucose tolerance test (75 g; OGTT) and the minimal model method. The latter method allows calculation of peripheral insulin sensitivity (Si) and glucose dependent glucose utilization (Sg). In PCOS, higher fasting concentrations (P < 0.05) of insulin and C-peptide, and lower Sg (P < 0.05) and Si (P < 0.01) were found. GnRHa did not significantly modify glucose metabolism of controls, while in women with PCOS it decreased fasting glucose (P < 0.05) and significantly increased Si (P < 0.03) up to control values. The present data indicate that strong suppression of ovarian activity improves Si in lean women with PCOS, while it is without relevant effects on glucose metabolism of non-hyperandrogenic women.
authors.affiliation: Institute of Obstetrics and Gynaecology of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cagnacci
authors.forename: A M
authors.initials: AM
authors.lastname: Paoletti
authors.forename: S
authors.initials: S
authors.lastname: Arangino
authors.forename: G B
authors.initials: GB
authors.lastname: Melis
authors.forename: A
authors.initials: A
authors.lastname: Volpe
mesh_terms: D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D017588:Hyperandrogenism / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism / Q000503:physiopathology; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*
chemical_list: D005947:Glucose