title: [Non-allergic rhinitis or intrinsic rhinitis? Unusual features of nickel allergy].
abstract: The clinical expression of nickel is known for its great diversity, from classical contact eczema to rhinitis, including work-related allergy, and by secondary hyperthermia to a metallic heart valve. Very often, hypersensitivity which may be of type I or type IV is secondary to contact of the hapten with sensitive cells, however some authors have reported the possibility of reactivation of lesions, especially dermatological (urticaria-eczema) by tests of oral ingestion. However, review of the literature does not mention the possibility of O.R.L. problems of the rhinitis type, from rhinosinusitis following ingestion of nickel and the two clinical cases that we report that involve one child of 11 years and one patient of 59 years, both of whom presented a serious rhinitis with a tendency to surperinfection, developing to perennial, where a patch-test to nickel was strongly positive, and who have seen an improvement in their clinical problems with a strict diet without this hapten. This confirms that the need is eventually physiopathological and suggests the necessity to search systematically for a possibility of hypersensitivity to haptens by the patch test technique in rhinitis that is labelled "non-allergic", by a negative reaginic history to pneumoallergens and trophallergens.
authors.affiliation: Laboratoire d'Immuno-Allergologie-CHU, Angers.
authors.forename: S
authors.initials: S
authors.lastname: Hassoun
authors.forename: A
authors.initials: A
authors.lastname: Sabbah
authors.forename: J L
authors.initials: JL
authors.lastname: Bouchereau
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D004342:Drug Hypersensitivity / Q000178:diet therapy / Q000188:drug therapy / Q000209:etiology*; D006241:Haptens / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D010328:Patch Tests; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced* / Q000175:diagnosis / Q000178:diet therapy / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D006241:Haptens; D007073:Immunoglobulin E; C029938:nickel sulfate; D009532:Nickel