[Chloroquine- and chlorphentermin-induced lipidosis in rat retina].
BACKGROUND
The amphiphilic drugs chloroquine and chlorphentermine are known to cause lipidosis in the human and rat retina.


METHODS
We treated femal albino Wistar rats orally with chloroquine for 12 weeks, followed by a period of 4 months with normal feed and another group with chlorphentermine for 4-16 weeks. The animals were submitted to electroretinography, and the retinae were prepared for histological investigations.


RESULTS
Chloroquine caused severe lipidosis in the neuroretina and slight photoreceptor cell degeneration after 12 weeks of treatment. The b-wave was reduced to 30% of initial values. After withdrawal the lipidosis remitted, but the degeneration of the photoreceptor cell layer continued to progress. The a-wave and b-wave amplitudes were reduced to 25% and 16% of initial values, respectively. Chlorphentermine caused pronounced lipidosis in the pigment epithelium and less numerous in the neuroretina after 16 weeks; no photoreceptor cell degeneration was found. The b-wave was reduced to 80% of initial values, the a-wave appeared unaffected.


CONCLUSIONS
Whether lipidosis is the primary cause of changes in the electroretinogram and of receptor cell degeneration is doubtful. Excessive lipid storage may be the cause of secondary changes. It is unlikely that lipidosis in pigment epithelium played a role.
Bredehorn
T
T
Klinik und Poliklinik für Augenheilkunde der Martin-Luther-Universität Halle-Wittenberg.
Duncker
G I
GI
D000284:Administration, Oral; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D002745:Chlorphentermine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D005260:Female; D008064:Lipidoses / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D017949:Retinal Cone Photoreceptor Cells / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D002738:Chloroquine; D002745:Chlorphentermine