Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, Aquacoat, or an organic ethylcellulose solution.
The objective was to investigate several factors (composition of the coating formulation, the type and pH of the release medium and curing conditions), which influence the drug release from beads coated with either the aqueous ethylcellulose dispersion, Aquacoat or an organic ethylcellulose solution. The chlorpheniramine maleate release from Aquacoat-coated beads was faster in pH 7.4 buffer than in 0.1 N HCl. Increasing the curing time and curing temperature decreased the drug release in pH 7.4 buffer but did not affect the release in 0.1 N HCl. In contrast, the drug release from beads coated with the ethanolic ethylcellulose solution was not affected by the curing step, the release medium or the addition of sodium lauryl sulfate. Scanning electron microscopy and contact angle measurements explained the release data. The differences in the drug release behavior of aqueous--and organic solvent--ethylcellulose--coated beads could be attributed to the differences in the film formation process.
Wesseling
M
M
College of Pharmacy, Freie Universität Berlin, Germany.
Bodmeier
R
R
D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D003102:Colloids; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011108:Polymers; D012996:Solutions; D014867:Water / Q000737:chemistry
D003102:Colloids; D011108:Polymers; D012996:Solutions; D014867:Water; C013517:ethyl cellulose; D002482:Cellulose