Hepatitis in falciparum malaria.
BACKGROUND
Hepatocellular jaundice occurring in patients with falciparum malaria has been called as malarial hepatitis.


METHODS
We studied 95 consecutive patients admitted with falciparum malaria. Of these 20 had evidence of malarial hepatitis. Their clinical presentation, complications and response to treatment was compared with that of patients without evidence of malarial hepatitis.


RESULTS
The clinical presentation of these patients was not different from those without hepatitis. However, the incidence of complications such as renal failure (60% vs 25%; X2 = 8.47, p < 0.01), Adult Respiratory Distress Syndrome (35% vs 3%; X2 = 18.13, p < 0.001) and septicemia (20% vs 6%; X2 = 4.01, p < 0.05) was significantly higher. The mortality also was higher in the group of patients with malarial hepatitis (40% vs 17%; X2 = 4.85, p < 0.05).


CONCLUSIONS
We conclude that the presence of hepatitis in patients with falciparum malaria indicates a more severe illness with a higher incidence of complications and a poor prognosis.
Murthy
G L
GL
Department of Medicine, Nizam's Institute of Medical Sciences, Panjagutta, Hyderabad, India.
Sahay
R K
RK
Sreenivas
D V
DV
Sundaram
C
C
Shantaram
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D006505:Hepatitis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007565:Jaundice / Q000453:epidemiology / Q000209:etiology*; D008111:Liver Function Tests; D016778:Malaria, Falciparum / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis