Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.
The effect of about 12 new compounds of Mannich bases of isatin against HIV-1 (IIIB) and HIV-2 (ROD) strains in MT 4 cells was studied. The screening method employed was MTT. In initial studies, one compound has shown maximum protection of 16% in subtoxic concentration.
Pandeya
S N
SN
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. snpande@banaras.ernet.in
Yogeeswari
P
P
Sriram
D
D
de Clercq
E
E
Pannecouque
C
C
Witvrouw
M
M
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D007510:Isatin / Q000138:chemical synthesis / Q000494:pharmacology*; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology*
D019380:Anti-HIV Agents; D008352:Mannich Bases; D007510:Isatin