An increase in vitamin A status by the feeding of conjugated linoleic acid.
Previous research indicated that conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. The present study showed a progressive increase in retinol (vitamin A alcohol) in the liver in proportion to CLA intake in rats that were fed different levels of CLA (in increments of 0.5%) for 1 month. The escalation reached a magnitude of about fivefold over the control at 2% dietary CLA. In contrast, the increase in liver retinyl esters peaked at about twofold between 0.5% and 1% CLA. Only retinol was detected in mammary tissue; a maximal twofold increase was attained at 0.5% CLA, and no dose-response effect was evident. The above findings are discussed in relation to two important questions: 1) How does CLA raise vitamin A status in the animal? 2) Is the increase in vitamin A associated with the anticarcinogenic effect of CLA?
Banni
S
S
Dipartimento di Biologia Sperimentale, Universitale degli Studi di Cagliari, Cittadella Universitaria, Italy.
Angioni
E
E
Casu
V
V
Melis
M P
MP
Scrugli
S
S
Carta
G
G
Corongiu
F P
FP
Ip
C
C
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D005260:Female; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013047:Specific Pathogen-Free Organisms; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
D014801:Vitamin A; D019787:Linoleic Acid