A functioning eccrine hamartoma associated with Down's syndrome (46, xx,-21,+t(21q21q).
Pure eccrine hamartomas are very rare, and commonly present as localized areas of hyperhidrosis in normal looking skin. We describe a case of bilateral functioning eccrine hamartomas with macroscopically abnormal features in association with Down's syndrome.
Nightingale
K J
KJ
Derriford Hospital, Derriford Road, Plymouth, Devon PL6 8DH, UK.
Newman
P
P
Davies
M G
MG
D001706:Biopsy; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004314:Down Syndrome / Q000150:complications / Q000235:genetics*; D004439:Eccrine Glands; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000235:genetics*; D006801:Humans; D006945:Hyperhidrosis / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D013543:Sweat Gland Diseases / Q000150:complications / Q000235:genetics*; D013546:Sweating; D014178:Translocation, Genetic