Anonymous oocyte donation performed exclusively with embryos cryopreserved at the pronuclear stage.
OBJECTIVE
To evaluate the clinical outcomes of patients who participated in an anonymous oocyte donation program that used embryos cryopreserved at the pronuclear stage.


METHODS
Observational study.


METHODS
A tertiary care reproductive medicine unit.


METHODS
Anonymous oocyte donors and their respective recipients.


METHODS
Oocyte donors underwent a standard controlled ovarian hyperstimulation protocol and transvaginal ultrasound-guided oocyte retrieval. Oocyte recipients underwent at least one programmed hormone replacement cycle with transcervical ET.


METHODS
Thaw survival, implantation, clinical and ongoing pregnancy rates.


RESULTS
Thirty-six oocyte retrievals resulted in one ET to date. The mean numbers of oocytes that were retrieved and normally fertilized were 18.2 and 11.6, respectively. Fifty-one embryo thaw-transfer cycles were performed, with an embryo thaw survival rate of 93.5%. The clinical and ongoing pregnancy rates per ET were 52.9% and 51%, respectively. The overall implantation rate was 28.7%. The percentage of oocyte retrievals that resulted in at least one ongoing pregnancy to date was 69.4%.


CONCLUSIONS
Anonymous oocyte donation can be conducted efficiently with the exclusive use of embryos cryopreserved at the pronuclear stage. This approach facilitates synchronization of the donor-recipient pair, eliminates the risk that recipients will begin hormonal therapy without embryo availability, and produces an acceptable ongoing pregnancy rate per oocyte donation.
Damario
M A
MA
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Hammitt
D G
DG
Galanits
T M
TM
Stevens
S A
SA
Session
D R
DR
Dumesic
D A
DA
D000328:Adult; D002970:Cleavage Stage, Ovum; D015925:Cryopreservation; D005314:Embryonic and Fetal Development; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D018587:Oocyte Donation / Q000379:methods*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D014463:Ultrasonography / Q000379:methods
D012739:Gonadal Steroid Hormones