Familial occurrence of chronic neutrophilic leukaemia.
A father and son who both developed chronic neutrophilic leukaemia (CNL) are reported. The father, aged 63, had been exposed to radioactive fallout after the atomic bomb attack on Hiroshima; he presented with hepatosplenomegaly and neutrophilic leucocytosis, and died of intracerebral haemorrhage 1 month after diagnosis. 4 years later his son, then aged 44, presented with neutrophilic leucocytosis. Leukaemic transformation to acute myelogenous leukaemia (AML-M1) occurred, and he died of refractory leukaemia 4 months after the diagnosis of CNL. This is the first report of this rare disease occurring in family members; genetic effect due to radioactive poisoning was suspected in the development of CNL in these two cases.
Kojima
K
K
Division of Haematology, Ehime Prefectural Central Hospital, Ehime, Japan.
Yasukawa
M
M
Hara
M
M
Nawa
Y
Y
Kimura
Y
Y
Narumi
H
H
Fujita
S
S
D000328:Adult; D002471:Cell Transformation, Neoplastic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics*; D008875:Middle Aged; D009689:Nuclear Warfare; D010375:Pedigree