title: Antireflux surgery in children under 3 months of age.
abstract: OBJECTIVE
  The aim of this study was to analyze the indications and results of fundoplication in 110 infants under 3 months of age.
  
  
  METHODS
  A retrospective review was conducted on the charts of all infants operated on for gastroesophageal reflux disease (GERD) at the UCLA Medical Center from January 1980 to December 1997. There were 59 boys and 51 girls. Recurrent emesis was the indication for operation in 62 of 110 infants, and respiratory symptoms in 85 of 110, with 54 of 110 having both. Neurological impairment was present in 32%. Prematurity was present in 21%; 35% had associated anomalies. Overall, 81 of 110 infants (73.6%) had one or more associated major malformations or disorders. Reflux was confirmed by upper gastrointestinal series findings in 63 of 78, esophageal pH monitoring in 60 of 62, and endoscopy in five of seven.
  
  
  RESULTS
  Mean age at operation was 1.8+/-0.1 months and mean weight was 3,686+/-90.2 g. A Nissen fundoplication was performed on 104 children, and six underwent a Thal procedure. Thirty-one had a gastric emptying procedure for delayed gastric emptying. Complications occurred in 7 infants. Emesis was controlled in 57 of 62 patients, aspiration in 38 of 48, and apneic spells in 54 of 57. Follow-up greater than 6 months was available for 73 patients. There were nine late deaths, all related to severe associated malformations. Seven patients required a redo fundoplication for recurrent reflux.
  
  
  CONCLUSIONS
  Nissen fundoplication can be performed safely in symptomatic infants under 3 months of age with low mortality and morbidity rates and with resolution of the presenting symptoms in 79% of infants.
authors.affiliation: Division of Pediatric Surgery, UCLA School of Medicine, Los Angeles, CA 90095-1749, USA.
authors.forename: E W
authors.initials: EW
authors.lastname: Fonkalsrud
authors.forename: J
authors.initials: J
authors.lastname: Bustorff-Silva
authors.forename: C A
authors.initials: CA
authors.lastname: Perez
authors.forename: R
authors.initials: R
authors.lastname: Quintero
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: J B
authors.initials: JB
authors.lastname: Atkinson
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation; D012189:Retrospective Studies