title: The physicochemical environment of the neonatal intestine.
abstract: Dietary intake, bacterial metabolites, and the secretion of factors (eg, proteins, electrolytes, lipid-soluble molecules, and water) by the body each contribute to the physicochemical environment of the gastrointestinal tract. Peristalsis regulates the changes along the length of the intestine. However, coordinated peristaltic responses develop as premature infants mature. In addition, the physicochemical environment of the center of the intestinal lumen differs from that of the epithelial surface. The area adjacent to the small intestinal epithelium is more acid than the bulk phase. Na+/H+ exchange antiporters in the epithelial cell apical membrane generate this acidity. Mucus maintains the acid microclimate by preventing free diffusion of hydrogen ions into the bulk phase. Development also affects these mechanisms. Changes in the lumenal environment may alter the synthesis of signaling molecules expressed by the intestinal epithelium. Thus, the epithelium, through changes in gene regulation, may act as an active interface that transmits information about the composition of the intestinal lumen to the mucosal immune system. Premature neonates are at risk of necrotizing enterocolitis, a disease almost exclusively associated with oral feeds. The pathogenesis of this condition may, in part, be due to the immaturity of the interactions between the physicochemical environment of the lumen and intestine.
authors.affiliation: Developmental Gastroenterology Laboratory, the Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Harvard Medical School, Boston, USA. I.R.Sanderson@mds.qmw.ac.uk
authors.forename: I R
authors.initials: IR
authors.lastname: Sanderson
mesh_terms: D016207:Cytokines / Q000737:chemistry / Q000502:physiology; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D004848:Epithelium / Q000737:chemistry / Q000382:microbiology / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007422:Intestines / Q000737:chemistry* / Q000382:microbiology / Q000502:physiology; D010528:Peristalsis; D015398:Signal Transduction
chemical_list: D016207:Cytokines