title: New controlled-release ibuprofen tablets.
abstract: Tablets containing two different doses of ibuprofen are realized. The first possesses very fast release kinetics, while the second has slow and linear release kinetics. This allows drug to produce a therapeutic effect quickly and to maintain it for a long time with only one administration unit. Such tablets are obtained by compression of a mixture of two very different kinds of granulates: an ibuprofen-starch granulate and an ibuprofen-Eudragit RS microsphere granulate. Specific proportions of mixtures of them give the described result after compression at particular tablet hardnesses.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
authors.forename: G F
authors.initials: GF
authors.lastname: Palmieri
authors.forename: D
authors.initials: D
authors.lastname: Lovato
authors.forename: S
authors.initials: S
authors.lastname: Martelli
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D007052:Ibuprofen / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013607:Tablets
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D007052:Ibuprofen