Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies.
BACKGROUND
Following the success of the NINCDS-ADRDA criteria for Alzheimer's disease, groups interested in vascular dementia and dementia with Lewy bodies have now adopted similar criteria.


OBJECTIVE
To assess whether the validity of these criteria are influenced by the prevalence of mixed pathologies or by the prevalence rate.


METHODS
A community based post-mortem study.


RESULTS
Mixed pathologies were common (33.8%). The high specificities obtained for the CDLB and NINDS-AIREN criteria (1.00 and 0.95, respectively) were associated with low sensitivities (0.22 and 0.43, respectively). Low prevalence and the presence of mixed pathologies had a deleterious effect on positive predictive values.


CONCLUSIONS
Current clinical diagnostic criteria are good at detecting pathology per se but not at detecting pure pathology. A large proportion of subjects from the general population fulfilling probable CDLB, probable NINCDS-ADRDA or probable NINDS-AIREN will have mixed pathologies.
Holmes
C
C
University of Southnampton, Thornhill Research Unit, Moorgreen Hospital, London.
Cairns
N
N
Lantos
P
P
Mann
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001344:Autopsy; D015140:Dementia, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity