Ternary complexes of palladium (II) with levamisole and L-amino acids.
The complexes of general formula [(LMS)2Pd(amino acid)]Cl with LMS = levamisole, and amino acid = L-alanine, L-phenylglycine, L-phenylalanine, L-valine, L-methionine, and L-proline, were synthesized by the interaction of [(LMS)2PdCl2] with the sodium salts of L-amino acids. The newly synthesized complexes are characterized by elemental analysis, conductivity, magnetic susceptibility, optical rotation measurements, and UV-Vis, IR and 13C NMR spectral data. Levamisole is coordinated to palladium via the N-7 nitrogen and the amino acids through the amino nitrogen and carboxylate oxygen, except for L-methionine which binds the metal via nitrogen and sulfur atoms. Optically active [(LMS)2Pd(amino acid)]Cl complexes are obtained when L-amino acids or D,L-amino acids are used for the synthesis of these complexes. L-Methionine and L-proline complexes induce new cell forms in Baker's yeast (Saccharomyces cerevisiae) cells.
Nijasure
A M
AM
Department of Chemistry, Institute of Science, Bombay, India.
Joshi
V N
VN
Sawant
A D
AD
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology; D000596:Amino Acids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D007978:Levamisole / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D000970:Antineoplastic Agents; D007978:Levamisole; D010165:Palladium