title: Intravitreal gas injection diminishes hyaluronic acid.
abstract: OBJECTIVE
  To determine if compression of the vitreous by an intraocular gas bubble diminishes the concentration of hyaluronic acid (NaHA).
  
  
  METHODS
  Eighteen albino rabbits had air, xenon or perfluoroethane (C2F6) injected into the vitreous to displace 12.5% to 90% of the vitreous volume. After the gas was absorbed, the vitreous was analyzed for NaHA by the Carbazole method (1, 13).
  
  
  RESULTS
  A 90% displacement diminished the NaHA concentration by 18.6%. Lesser displacements caused a lesser loss, but the differences are not significant.
  
  
  CONCLUSIONS
  Intraocular gas injections, both large and small, reduce the concentration of NaHA and destabilize the vitreous structure.
authors.affiliation: Department of Ophthalmology, New York Hospital-Cornell Medical Center, New York, USA.
authors.forename: H
authors.initials: H
authors.lastname: Lincoff
authors.forename: I
authors.initials: I
authors.lastname: Kreissig
authors.forename: J
authors.initials: J
authors.lastname: Horowitz
authors.forename: R
authors.initials: R
authors.lastname: Silverman
mesh_terms: D000388:Air; D000417:Albinism; D000818:Animals; D005466:Fluorocarbons / Q000494:pharmacology; D005740:Gases / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000378:metabolism*; D007267:Injections; D011817:Rabbits; D014822:Vitreous Body / Q000187:drug effects; D014978:Xenon / Q000494:pharmacology
chemical_list: D005466:Fluorocarbons; D005740:Gases; D014978:Xenon; C048381:perfluoroethane; D006820:Hyaluronic Acid