The discovery of T cell help for B cell antibody formation: a perspective from the 30th anniversary of this discovery.
Thirty years ago, Miller and Mitchell described the bone-marrow origin of antibody-forming cells and the thymic origin of the help needed to activate the bone-marrow-derived antibody formation. Since then, there has been a continuous stream of discovery in Australia, from Zinkernagel and Doherty's description of MHC-restricted antigen recognition to Goodnow's dissection of the maturation and tolerization of antigen-specific B cells. All of these discoveries, and many more described in the text, contribute to the modern synthesis in immunology.
Janeway
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Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. charles.janeway@yale.edu
D000486:Allergy and Immunology / Q000266:history*; D000917:Antibody Formation; D001315:Australia; D001402:B-Lymphocytes / Q000276:immunology*; D004739:England; D049673:History, 20th Century; D013601:T-Lymphocytes / Q000276:immunology*