title: [Three children with systemic cat scratch disease].
abstract: Three girls with systemic cat scratch disease, aged 10, 13 and 9 years, were reported. They presented a prolonged fever and back pain in the early stage of the disease, and had no regional lymphadenopathy. Two of them had hepatosplenic granulomas, one with multiple 5 mm hypoechoic lesions in the liver and spleen, and the other with a single 2.5 cm hypodense lesion in the left hepatic lobe. The latter patient underwent a partial left hepatic lobectomy. All patients had elevated titers of antibodies to Bartonella henselae. Polymerase chain reaction detected B. henselae DNA in tissue specimens of the patient who underwent a hepatic lobectomy. Cat scratch disease should be recognized as a cause of fever of unknown origin because the prevalence of B henselae infection might be higher in Japan.
authors.affiliation: Department of Pediatrics, Yamaguchi Prefecture Central Hospital.
authors.forename: I
authors.initials: I
authors.lastname: Murano
authors.forename: H
authors.initials: H
authors.lastname: Yoshii
authors.forename: H
authors.initials: H
authors.lastname: Kurashige
authors.forename: Y
authors.initials: Y
authors.lastname: Sugio
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: T
authors.initials: T
authors.lastname: Shinohara
authors.forename: H
authors.initials: H
authors.lastname: Tsuneoka
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Iino
authors.forename: R
authors.initials: R
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Fujisawa
authors.forename: M
authors.initials: M
authors.lastname: Tsukahara
mesh_terms: D000293:Adolescent; D002372:Cat-Scratch Disease / Q000175:diagnosis*; D002648:Child; D005260:Female; D005335:Fever of Unknown Origin; D006801:Humans