Bioactive sesquiterpenes from a Taiwanese marine sponge Parahigginsia sp.
Five new sesquiterpenes, parahigginols A-D (1-4) and parahigginic acid (5), have been isolated from a Taiwanese marine sponge Parahigginsia sp. The structural assignments of the new compounds were based on their spectral data, including 1D and 2D NMR. Biological studies revealed that compounds 2-5 exhibited cytotoxicity against murine P-388 and human KB16, A549, and HT-29 tumor cells.
Chen
C Y
CY
Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Shen
Y C
YC
Chen
Y J
YJ
Sheu
J H
JH
Duh
C Y
CY
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes