Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide.
BACKGROUND
Chronic hypercalciuria can contribute to osteoporosis, particularly in men.


OBJECTIVE
To ascertain the effects of resolution of hypercalciuria on bone mineral density.


METHODS
Case series.


METHODS
Referral service for metabolic bone disease in a tertiary-care teaching hospital.


METHODS
Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis.


METHODS
Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months.


METHODS
Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration.


RESULTS
Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively.


CONCLUSIONS
Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.
Adams
J S
JS
Burns and Allen Research Institute and Cedars-Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA. adamsj@cshs.org
Song
C F
CF
Kantorovich
V
V
D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000652:urine*; D002908:Chronic Disease; D003404:Creatinine / Q000652:urine; D004232:Diuretics; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D003404:Creatinine; D002118:Calcium