title: The voltammetric behavior of bone marrow of leukaemia and its clinical application.
abstract: The electrochemical voltammetric behavior of bone marrow of leukaemia has been investigated by a self-devised cytosensing system. The two anodic peaks of erythrocytes (red blood cells, RBC) in bone marrow of leukaemia appeared at 0.73 +/- 0.03 and 0.83 +/- 0.02V vs. SCE, respectively, on the first scan. The anodic peak of leukocytes (white blood cells, WBC) appeared at 0.32 +/- 0.03V vs. SCE. The anodic peak of RBC at 0.83V disappeared when the patients were cured. The experimental results show that the voltammetric behavior of erythrocytes is in constant contact with the initial stage of leukaemia. The cyclic voltammetric behavior of 40 cases of leukaemia including acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML) and 10 cases of healthy volunteer peripheral blood was studied. The cyclic voltammetric behavior of erythrocytes may provide a simple and specific marker for diagnosis of leukaemia.
authors.affiliation: Department of Chemistry, Peking University, Beijing, China.
authors.forename: H N
authors.initials: HN
authors.lastname: Li
authors.forename: Y X
authors.initials: YX
authors.lastname: Ci
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.forename: K
authors.initials: K
authors.lastname: Cheng
authors.forename: S
authors.initials: S
authors.lastname: Fu
authors.forename: D B
authors.initials: DB
authors.lastname: Wang
mesh_terms: D001853:Bone Marrow / Q000737:chemistry / Q000503:physiopathology*; D002021:Buffers; D004563:Electrochemistry; D004594:Electrophysiology; D004912:Erythrocytes / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000473:pathology* / Q000628:therapy; D007948:Leukemia, Monocytic, Acute / Q000097:blood / Q000473:pathology / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000473:pathology / Q000628:therapy; D007962:Leukocytes / Q000502:physiology
chemical_list: D002021:Buffers