title: The antiproliferative effect of acridone alkaloids on several cancer cell lines.
abstract: Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure-activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-1 and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones.
authors.affiliation: National Institute of Fruit Tree Science, Okitsu, Shimizu, Shizuoka, 424-0204, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kawaii
authors.forename: Y
authors.initials: Y
authors.lastname: Tomono
authors.forename: E
authors.initials: E
authors.lastname: Katase
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Takemura
authors.forename: M
authors.initials: M
authors.lastname: Ju-ichi
authors.forename: C
authors.initials: C
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000166:Acridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D054831:Acridones; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000166:Acridines; D054831:Acridones; D000470:Alkaloids; D000970:Antineoplastic Agents; C041300:acridone