title: [Constrictive bronchiolitis obliterans. Apropos of a case].
abstract: BACKGROUND
  Constrictive bronchiolitis obliterans is defined histologically as obliteration of the lumina of bronchioles by inflammatory tissue elements and progressive destruction of bronchioles, eventually replaced by fibrotic tissue. Most of the cases, which are not associated with either solid organ or bone marrow transplantation, occur in the development of rheumatoid arthritis.
  
  
  METHODS
  We present the case of a 73-year-old woman who developed severe constrictive bronchiolitis obliterans without readily identifiable cause, rapidly fatal despite corticosteroid therapy. The patient had antinuclear antibodies (titer 1/1024) and antiphospholipid antibodies, but there was no anti-DNA, anti-ENA or anti-beta 2GPI antibodies. Tests for rheumatoid factor were negative. Cryoglobulinemia was present (monoclonal IgM Kappa).
  
  
  CONCLUSIONS
  In this case, constrictive bronchiolitis obliterans was associated with serologic abnormalities and cryoglobulinemia. However, were was no clinical evidence of connective tissue disease.
authors.affiliation: Service de médecine interne, centre hospitalier Lyon-Sud, Pierre-Bénite, France.
authors.forename: T
authors.initials: T
authors.lastname: Zenone
authors.forename: S
authors.initials: S
authors.lastname: Isaac
authors.forename: P J
authors.initials: PJ
authors.lastname: Souquet
authors.forename: C
authors.initials: C
authors.lastname: Grange
authors.forename: P
authors.initials: P
authors.lastname: Loubeyre
authors.forename: I
authors.initials: I
authors.lastname: Durieu
authors.forename: D
authors.initials: D
authors.lastname: Vital Durand
mesh_terms: D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D001989:Bronchiolitis Obliterans / Q000175:diagnosis / Q000276:immunology; D003449:Cryoglobulinemia / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid