title: MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease.
abstract: We have studied MHC class II antigen expression and lymphocytic infiltration during dopaminergic neurone degeneration produced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP). Microglial activation was observed in the striatum and in the substantia nigra (SN) in this model. We noticed a marked increase of MHC class II antigen expression on microglia and T-cell recruitment in these regions after MPTP treatment. B-lymphocytes were not observed. T-cell infiltration predominantly consisted of CD8+ cells at every time point but CD4+ cells were present too. More than a half of the observed lymphocytes showed strong staining of CD44 antigen. Our findings suggest a possible immune system involvement in the pathological process following MPTP intoxication.
authors.affiliation: Department of Pharmacology, Medical Academy of Warsaw, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Kurkowska-Jastrzebska
authors.forename: A
authors.initials: A
authors.lastname: Wrońska
authors.forename: M
authors.initials: M
authors.lastname: Kohutnicka
authors.forename: A
authors.initials: A
authors.lastname: Członkowski
authors.forename: A
authors.initials: A
authors.lastname: Członkowska
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D015259:Dopamine Agents; D005805:Genes, MHC Class I / Q000235:genetics*; D006651:Histocytochemistry; D008214:Lymphocytes / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000473:pathology*; D017072:Neostriatum / Q000473:pathology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*
chemical_list: D015259:Dopamine Agents; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine