[Meningococcal sepsis in 3 young men].
METHODS
Three young men became ill one after the other with fever, headaches, vomiting, arthralgias and muscle pain. One day after beginning of symptoms all three patients developed a haemorrhagic rash with petechial and ecchymotic lesions most intense on distal extremities. 24 hours later patient no. 1 and 3 were in septic shock.


METHODS
Laboratory tests showed signs of systemic infection, disseminated intravascular coagulation and renal failure. On the day of admission to the hospital blood cultures showed Neisseria meningitidis in patient no. 1 and 3. In patient no. 2 blood cultures were negative.


METHODS
Intravenous antibiotic therapy was started immediately after admission. In patient no. 1 and 3 purpura fulminans with multiple organ failure demanded intensive care treatment. Patient no. 1 recovered. Necrotic toes made amputations necessary. Patient no. 2 was never critically ill. Patient no. 3, whose course was complicated by a long lasting disseminated intravascular coagulation, died from massive cerebral bleeding 6 days after admission. Patient no. 2, who was treated with ciprofloxacin after symptoms began was never critically ill.


CONCLUSIONS
Neisseria meningitidis sepsis has a high mortality rate. Rapid admission to the hospital and beginning of an antibiotic therapy with penicillin G or a third-generation cephalosporin is a priority when meningococcal disease is suspected. Chemoprophylaxis should be offered to close contacts of patients.
Diet
F
F
Klinik III für Innere Medizin, Universität Köln.
Hartmann
P
P
Lang
A
A
Fätkenheuer
G
G
Diehl
V
V
Erdmann
E
E
D000208:Acute Disease; D000293:Adolescent; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D009336:Necrosis; D009345:Neisseria meningitidis / Q000302:isolation & purification; D011693:Purpura / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy; D012772:Shock, Septic / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy; D012867:Skin / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy