Statistical mechanics of protein-like heteropolymers.
A strategy is outlined for obtaining the free energy of a typical designed heteropolymer. The design procedure considers the probability that the target conformation is occupied in comparison with all the other conformations that could house the given sequence. Numerical calculations on lattice heteropolymer models are presented to illustrate the key physical principles.
Dima
R I
RI
Department of Physics and Center for Materials Physics, 104 Davey Laboratory, Pennsylvania State University, University Park, PA 16802, USA. dima@phys.psu.edu
Banavar
J R
JR
Cieplak
M
M
Maritan
A
A
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D015233:Models, Statistical; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D011108:Polymers; D011506:Proteins