title: Immunoprotective effect of IM-133.
abstract: We studied the immunoprotective effect of IM-133, a poly-herbal formulation, against E. coli-induced intra-abdominal sepsis. Treatment with IM-133 afforded protection against the septic shock induced mortality. The in vivo treatment has enhanced nitric oxide production and phagocytic ability against C. albicans by peritoneal macrophages in Balb/c mice. The protective effect of IM-133 appears to be by virtue of its immunomodulatory activity and finds application in the clearance of intra-cellular pathogens.
authors.affiliation: R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: T
authors.initials: T
authors.lastname: Suryanarayana
authors.forename: D N
authors.initials: DN
authors.lastname: Sarma
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000096:biosynthesis; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy
chemical_list: D000276:Adjuvants, Immunologic; D009569:Nitric Oxide