title: Angiopoietin-3, a novel member of the angiopoietin family.
abstract: A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.
authors.affiliation: The Program of the Chiba University School of Medicine, Chiba University Graduate School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Miki
authors.forename: R
authors.initials: R
authors.lastname: Yashima
authors.forename: N
authors.initials: N
authors.lastname: Yokoi
authors.forename: H
authors.initials: H
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Seino
mesh_terms: D000595:Amino Acid Sequence; D000091304:Angiopoietin-Like Protein 1; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002890:Chromosomes, Human, Pair 20; D003001:Cloning, Molecular; D016208:Databases, Factual; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D005810:Multigene Family; D020161:Physical Chromosome Mapping; D011506:Proteins / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D016324:Sequence Tagged Sites; D014018:Tissue Distribution
chemical_list: C117578:ANGPTL1 protein, human; D000091304:Angiopoietin-Like Protein 1; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins