A complete remote-control system for reliable preparation of [18F]altanserin.
A complete remote control system was constructed for production of the PET 5-HT2A ligand [18F]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality.
Tan
P Z
PZ
VA PET Center, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA. pingzhong.tan@yale.edu
Baldwin
R M
RM
Soufer
R
R
Garg
P K
PK
Charney
D S
DS
Innis
R B
RB
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D007650:Ketanserin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000302:isolation & purification; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C071983:altanserin; D007650:Ketanserin