New Bis(Indole) alkaloids of the topsentin class from the sponge spongosorites genitrix
Four bis(indole) alkaloids of the topsentin class, including two new brominated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel compounds were determined by spectroscopic methods. These compounds exhibited moderate cytotoxicity against a human leukemia cell-line (K-562).
Shin
J
Marine Natural Products Laboratory, Korea Ocean Research & Development Institute, Ansan P.O. Box 29, Seoul 425-600, and Department of Biology, Han Nam University, Taejeon 300-791, Korea.
Seo
Y
Cho
KW
Rho
JR
Sim
CJ