Partial regression of advanced cyclosporin-induced gingival hyperplasia after treatment with azithromycin. A case report.
Gingival hyperplasia is a well recognised complication of cyclosporin A therapy. Although its pathogenesis is still debated in several recent reports a second generation macrolide antibiotic-azithromycin induced partial or even complete regression of hyperplasia. We present a patient after kidney transplantation treated with cyclosporin who developed very advanced gigival overgrowth (stage 3+). The patient received a 3-day treatment with azithromycin which was repeated after 3 months. The first course of the drug caused a partial regression of gingival hyperplasia during following months but the repeated treatment did not provide a further regression of the changes.
Nowicki
M
M
Department of Nephrology, Endocrinology and Metabolic Diseases of the Silesian Academy of Medicine, Katowice, Poland. nefro@infomed.slam.katowice.pl
Kokot
F
F
Wiecek
A
A
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005885:Gingival Hyperplasia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000276:immunology*; D011183:Postoperative Complications
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D017963:Azithromycin; D016572:Cyclosporine