Prominent effect of immunoadsorption plasmapheresis therapy in a patient with chronic inflammatory demyelinating polyneuropathy associated with hepatitis B infection.
We encountered a patient with chronic inflammatory demyelinating polyneuropathy associated with hepatitis B infection. Immunohistochemical study revealed the deposition of immune complex composed of hepatitis B surface antigen (HBsAg) both around the endoneural capillary and in the endoneurium. Neurological signs were significantly improved by immunoadsorption plasmapheresis (IAPP) treatment without incorporating corticosteroid hormone therapy; weekly long-term IAPP has successfully maintained the patient's condition.
Inoue
A
A
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Oguchi
K
K
Iwahashi
T
T
Arakura
H
H
Koh
C S
CS
D000936:Antigen-Antibody Complex / Q000032:analysis; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000628:therapy*; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D007163:Immunosorbent Techniques; D008875:Middle Aged; D010525:Peripheral Nerves / Q000276:immunology; D010956:Plasmapheresis; D011115:Polyneuropathies / Q000628:therapy*
D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens