Bilirubin adsorbent column for plasma perfusion.
To eliminate protein-bound toxic substances, plasma exchange was introduced. In the case of fulminant hepatitis or other hepatic failure, the supply of coagulation factors is usually necessary; therefore, plasma exchange is a suitable method for the elimination of protein-bound toxins, for example, bilirubin. However, plasma exchange needs fresh frozen plasma or another protein fraction from humans, and virus contamination or other infectious factors are a serious problem. In the case of bilirubin, anion exchange resin was used to try to eliminate this toxic substance from the patient's blood or plasma. In Japan a bilirubin adsorption column for plasma perfusion has been put to practical use. This review outlines the characteristics of this bilirubin adsorbent.
Takenaka
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Technical Department, Asahi Medical Co., Ltd., Tokyo, Japan.
D000327:Adsorption; D000837:Anion Exchange Resins; D006464:Hemoperfusion; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy*; D017093:Liver Failure / Q000628:therapy*; D010951:Plasma Exchange; D016060:Sorption Detoxification
D000837:Anion Exchange Resins