title: Loss of HLA haplotype in lung cancer cell lines: implications for immunosurveillance of altered HLA class I/II phenotypes in lung cancer.
abstract: Loss of expression of HLA class I antigens has been demonstrated in a wide variety of tumors and is considered to be one of the mechanisms whereby tumors escape T-cell surveillance. Genomic DNA of MHC class I/II molecules in seven lung cancer cell lines was investigated and compared with that in peripheral blood mononuclear cells. In three cell lines, OU-LC-A1, OU-LC-A2, and OU-LC-AS1, a loss of HLA haplotype was observed. Aberrations of HLA class I/II in tumor cell lines should be considered when MHC-restricted phenomena in vitro models are assessed and clinical use of tumor vaccination in vivo is considered.
authors.affiliation: Second Department of Medicine, Okayama University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hiraki
authors.forename: T
authors.initials: T
authors.lastname: Kaneshige
authors.forename: K
authors.initials: K
authors.lastname: Kiura
authors.forename: H
authors.initials: H
authors.lastname: Ueoka
authors.forename: H
authors.initials: H
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Harada
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000276:immunology*; D004247:DNA / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007157:Immunologic Surveillance; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology*; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012703:Serotyping; D014407:Tumor Cells, Cultured
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D004247:DNA