title: Prognostic models of thirty-day mortality and morbidity after major pulmonary resection.
abstract: BACKGROUND
  A part of the prospective, multi-institutional National Veterans Affairs Surgical Quality Improvement Program was developed to predict 30-day mortality and morbidity for patients undergoing a major pulmonary resection.
  
  
  METHODS
  Perioperative data were acquired from 194,319 noncardiac surgical operations at 123 Veterans Affairs Medical Centers between October 1, 1991, and August 31, 1995. Current Procedural Terminology code-based analysis was undertaken for major pulmonary resections (lobectomy and pneumonectomy). Preoperative, intraoperative, and outcome variables were collected. The 30-day mortality and morbidity models were developed by means of multivariable stepwise logistic regression with the preoperative and intraoperative variables used as independent predictors of outcome.
  
  
  RESULTS
  A total of 3516 patients (mean age 64 9 years) underwent either lobectomy (n = 2949) or pneumonectomy (n = 567). Thirty-day mortality was 4.0% for lobectomy (119/2949) and 11.5% for pneumonectomy (65/567). The preoperative predictors of 30-day mortality were albumin, do not resuscitate status, transfusion of more than 4 units, age, disseminated cancer, impaired sensorium, prothrombin time more than 12 seconds, type of operation, and dyspnea. When the intraoperative variables were considered, intraoperative blood loss was added to the preoperative model. In the presence of these intraoperative variables in the model, do not resuscitate status and prothrombin time more than 12 seconds were only marginally significant. Thirty-day morbidity, defined as the presence of 1 or more of the 21 predefined complications, was 23.8% for lobectomy (703/2949) and 25.7% for pneumonectomy (146/567). In multivariable models, independent preoperative predictors (P <.05) of 30-day morbidity were age, weight loss greater than 10% in the 6 months before surgery, history of chronic obstructive pulmonary disease, transfusion of more than 4 units, albumin, hemiplegia, smoking, and dyspnea. When intraoperative variables were added to the preoperative model, the duration of operation time and intraoperative transfusions were included in the model and albumin became marginally significant.
  
  
  CONCLUSIONS
  This analysis identifies independent patient risk factors that are associated with 30-day mortality and morbidity for patients undergoing a major pulmonary resection. This series provides an initial risk-adjustment model for major pulmonary resections. Future refinements will allow comparative assessment of surgical outcomes and quality of care at many institutions.
authors.affiliation: Veterans Affairs Medical Center/Harvard Medical School, Brockton/West Roxbury, MA, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: Harpole
authors.forename: M M
authors.initials: MM
authors.lastname: DeCamp
authors.forename: J
authors.initials: J
authors.lastname: Daley
authors.forename: K
authors.initials: K
authors.lastname: Hur
authors.forename: C A
authors.initials: CA
authors.lastname: Oprian
authors.forename: W G
authors.initials: WG
authors.lastname: Henderson
authors.forename: S F
authors.initials: SF
authors.lastname: Khuri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006753:Hospital Records / Q000706:statistics & numerical data; D006787:Hospitals, Veterans / Q000706:statistics & numerical data; D006801:Humans; D008171:Lung Diseases / Q000453:epidemiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D016017:Odds Ratio; D011013:Pneumonectomy / Q000401:mortality*; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D015996:Survival Rate; D014481:United States / Q000453:epidemiology; D014493:United States Department of Veterans Affairs / Q000706:statistics & numerical data