title: Dialysis modality and the risk of allograft thrombosis in adult renal transplant recipients.
abstract: BACKGROUND
  Renal vascular thrombosis (RVT) is a rare but catastrophic complication of renal transplantation. Although a plethora of risk factors has been identified, a large proportion of cases of RVT is unexplained. Uremic coagulopathy and dialysis modality may predispose to RVT. We investigated the impact of the pretransplant dialysis modality on the risk of RVT in adult renal transplant recipients.
  
  
  METHODS
  Renal transplant recipients (age 18 years or more) who were enrolled in the national registry between 1990 and 1996 (N = 84,513) were evaluated for RVT occurring within 30 days of transplantation. Each case was matched with two controls from the same transplant center and with the year of transplantation. The association between RVT and 18 factors was studied with multivariate conditional logistic regression.
  
  
  RESULTS
  Forty-nine percent of all cases of RVT (365 out of 743) occurred in repeat transplant recipients with an adjusted odds ratio (OR) of 5.72 compared with first transplants (P < 0.001). There were a significantly higher odds of RVT in peritoneal dialysis (PD)-compared with hemodialysis (HD)-treated patients (OR = 1.87, P = 0.001). Change in dialysis modality was an independent predictor of RVT: switching from HD to PD (OR = 3.59, P < 0.001) and from PD to HD (OR = 1.62, P = 0.047). Compared with primary transplant recipients on HD (OR = 1.00), the highest odds of RVT were in repeat transplant recipients treated with PD (OR = 12.95, P < 0.001) and HD (OR = 4.50, P < 0.001). Other independent predictors of RVT were preemptive transplantation, relatively young and old donor age, diabetes mellitus and systemic lupus erythematosus as causes of end-stage renal disease, recipient gender, and lower panel reactive antibody levels (PRAs).
  
  
  CONCLUSIONS
  The strongest risk factors for RVT were retransplantation and prior PD treatment. Prevention of RVT with perioperative anticoagulation should be studied in patients who have a constellation of the identified risk factors.
authors.affiliation: Department of Medicine, University of Michigan, Veteran Administration Hospital, Ann Arbor, USA. aojo@umich.edu
authors.forename: A O
authors.initials: AO
authors.lastname: Ojo
authors.forename: J A
authors.initials: JA
authors.lastname: Hanson
authors.forename: R A
authors.initials: RA
authors.lastname: Wolfe
authors.forename: L Y
authors.initials: LY
authors.lastname: Agodoa
authors.forename: S F
authors.initials: SF
authors.lastname: Leavey
authors.forename: A
authors.initials: A
authors.lastname: Leichtman
authors.forename: E W
authors.initials: EW
authors.lastname: Young
authors.forename: F K
authors.initials: FK
authors.lastname: Port
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D010530:Peritoneal Dialysis / Q000706:statistics & numerical data*; D011183:Postoperative Complications / Q000453:epidemiology*; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D012307:Risk Factors; D014184:Transplantation, Homologous; D020246:Venous Thrombosis / Q000453:epidemiology*