Blockade of GABAA receptors in the medial ventral pallidum elicits feeding in satiated rats.
gamma-aminobutyric acid (GABA)-containing fibers from the nucleus accumbens shell (AcbSh) terminate in the medial ventral pallidum (VPm) and neurons in the VPm project to the lateral hypothalamus (LH). Therefore, the VPm is anatomically interposed between the AcbSh and LH, two functionally related brain regions that mediate food intake. The present study demonstrates that blockade of GABAA receptors in the VPm by local administration of bicuculline greatly increases food intake in satiated rats. The data suggest that an AcbSh-VPm-LH circuit may be involved in the control of feeding behavior.
Stratford
T R
TR
Department of Pharmacology, MCP Hahnemann University, 3200 Henry Ave, Philadelphia, PA 19129, USA. stratford@nrifargo.com
Kelley
A E
AE
Simansky
K J
KJ
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking; D004435:Eating; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology*; D005917:Globus Pallidus / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D008297:Male; D009434:Neural Pathways; D009714:Nucleus Accumbens / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000502:physiology*; D012527:Satiation / Q000187:drug effects* / Q000502:physiology
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D001640:Bicuculline