title: Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2'-deoxyadenosine.
abstract: A few cases of secondary neoplasms occurring after treatment with 2-chloro-2'-deoxyadenosine (2CdA) have been reported, mostly in patients previously exposed to other anti-cancer drugs including alkylating agents (AA). Here we report on the occurrence of a myelodysplastic syndrome (MDS) with monosomy 5 and/or 7 in two patients after 2CdA treatment, without or prior to other toxic exposure. In light of a literature review and given the involvement of chromosomes frequently abnormal in secondary leukaemias, we suggest that 2CdA may induce therapy-related MDS (t-MDS).
authors.affiliation: Department of Haematology, Cliniques Universitaires Saint-Luc, Catholic University of Louvain, Brussels, Belgium. vandenneste@sang.ucl.ac.be
authors.forename: E
authors.initials: E
authors.lastname: Van Den Neste
authors.forename: I
authors.initials: I
authors.lastname: Louviaux
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: A
authors.initials: A
authors.lastname: Delannoy
authors.forename: L
authors.initials: L
authors.lastname: Michaux
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: J M
authors.initials: JM
authors.lastname: Scheiff
authors.forename: A
authors.initials: A
authors.lastname: Bosly
authors.forename: N
authors.initials: N
authors.lastname: Straetmans
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D017338:Cladribine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics*; D009190:Myelodysplastic Syndromes / Q000188:drug therapy / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine