title: Tissue response to porous tantalum acetabular cups: a canine model.
abstract: This study evaluated the osseous tissue response to a noncemented metal-backed acetabular component made of a new porous tantalum biomaterial. Eleven dogs with bilateral total hip arthroplasties (22 acetabular implants) were studied for a period of 6 months. Thin section histology, high-resolution radiography, and backscattered scanning electron microscopy revealed that all 22 implants had stable bone-implant interfaces. Regions of bone ingrowth were present in all histologic sections. The depth of bone ingrowth varied from 0.2 mm to the maximal limit of 2 mm. Analyzing contiguous regions of interest across the full bone-implant interface, the mean bone ingrowth for all sections was 16.8% +/- 5.7%. In the peripheral regions of the cup where bone-implant contact was most consistent, bone ingrowth averaged 25.1% +/- 10.1%. The data indicate that the porous tantalum material is effective for biologic fixation in the dog and may provide a suitable alternative to other porous materials used in acetabular cup design.
authors.affiliation: Division of Orthopaedics, Montreal General Hospital, McGill University, Quebec, Canada.
authors.forename: J D
authors.initials: JD
authors.lastname: Bobyn
authors.forename: K K
authors.initials: KK
authors.lastname: Toh
authors.forename: S A
authors.initials: SA
authors.lastname: Hacking
authors.forename: M
authors.initials: M
authors.lastname: Tanzer
authors.forename: J J
authors.initials: JJ
authors.lastname: Krygier
mesh_terms: D000077:Acetabulum / Q000648:ultrastructure; D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D001672:Biocompatible Materials; D004285:Dogs; D006622:Hip Prosthesis; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D016062:Porosity; D011474:Prosthesis Design; D013635:Tantalum
chemical_list: D001672:Biocompatible Materials; D013635:Tantalum