title: [Rectal resection for cancer in Lower-Normandy. Loco-regional recurrences and survival. Results of a regional survey (1988-1993)].
abstract: OBJECTIVE
  A retrospective regional study was set up to identify the determinants of loco-regional recurrences and those of survival after rectal resection for cancer. The studied population was constituted of 505 patients with resection for carcinoma of the rectum in Lower-Normandy from 1988 to 1993.
  
  
  RESULTS
  The actuarial rate of loco-regional recurrence was 17.3 +/- 4% at 3 years. The only significant predictive factor of survival free of loco-regional recurrence was the Dukes' stage. Actuarial survival rate was 52.0 +/- 4% at 5 years, the corresponding relative survival rate being 64.6 +/- 6%. The only two independent prognostic factors were the sphincter-saving procedure and adjuvant radiotherapy.
  
  
  CONCLUSIONS
  The loco-regional recurrence rate after resection for rectal cancer is still high. Sphincter-saving procedure and adjuvant radiotherapy increase over the time. Since the study was retrospective, no definitive conclusions could be drawn. Nevertheless, they incite us to set up larger prospective regional studies including quality control of surgical procedures, radiotherapy protocols and histopathological reports.
authors.affiliation: Registre des Tumeurs Digestives du Calvados, CJF INSERM, Faculté de Médecine, Caen.
authors.forename: N
authors.initials: N
authors.lastname: Desoubeaux
authors.forename: J
authors.initials: J
authors.lastname: Maurel
authors.forename: T
authors.initials: T
authors.lastname: Petit
authors.forename: G
authors.initials: G
authors.lastname: Launoy
authors.forename: M
authors.initials: M
authors.lastname: Gignoux
mesh_terms: D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors