title: Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
abstract: Only few cases of Behçet's and hematological malignancies have been reported until now. We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years. This case is reported and the occurrence of hematological malignancies and Behçet's disease is reviewed.
authors.affiliation: Department of Medicine III, University of Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bangerter
authors.forename: M
authors.initials: M
authors.lastname: Griesshammer
authors.forename: C
authors.initials: C
authors.lastname: v Tirpitz
authors.forename: J
authors.initials: J
authors.lastname: Krauter
authors.forename: G
authors.initials: G
authors.lastname: Heil
authors.forename: M
authors.initials: M
authors.lastname: Hafner
authors.forename: W
authors.initials: W
authors.lastname: Kern
authors.forename: M
authors.initials: M
authors.lastname: Heiss
authors.forename: P
authors.initials: P
authors.lastname: Kern
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D001528:Behcet Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D001854:Bone Marrow Cells; D002699:Chlorambucil / Q000008:administration & dosage; D002897:Chromosomes, Human, Pair 7; D016572:Cyclosporine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D009006:Monosomy / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D016572:Cyclosporine