title: A new cytotoxic acyclic diterpene from Carpesium divaricatum.
abstract: A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxygeranylgeraniol (2) were isolated from the aerial parts of Carpesium divaricatum. The structure of 1 was determined to be (2E,10E)-1,12-dihydroxy-18-acetoxy-3,7,15-trimethylhexadeca- 2,10,14-triene (1) on the basis of spectroscopic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 values ranging from 4.3-10.2 micrograms/ml and 4.1-8.3 micrograms/ml, respectively.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, Sung Kyun Kwan University, Suwon, Korea.
authors.forename: O P
authors.initials: OP
authors.lastname: Zee
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: S U
authors.initials: SU
authors.lastname: Choi
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: K R
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic