title: 4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists.
abstract: A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
authors.affiliation: DuPont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cocuzza
authors.forename: F W
authors.initials: FW
authors.lastname: Hobbs
authors.forename: C R
authors.initials: CR
authors.lastname: Arnold
authors.forename: D R
authors.initials: DR
authors.lastname: Chidester
authors.forename: J A
authors.initials: JA
authors.lastname: Yarem
authors.forename: S
authors.initials: S
authors.lastname: Culp
authors.forename: L
authors.initials: L
authors.lastname: Fitzgerald
authors.forename: P J
authors.initials: PJ
authors.lastname: Gilligan
mesh_terms: D002460:Cell Line; D006801:Humans; D011485:Protein Binding; D011743:Pyrimidines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011743:Pyrimidines; D018019:Receptors, Corticotropin-Releasing Hormone; D011994:Recombinant Proteins