The use of TL detectors in dosimetry of systemic radiation therapy.
A method for determining absorbed doses to organs in systemic radiation therapy (SRT) is evaluated. The method, based on thermoluminescent (TL) dosimeters placed on the patient's skin, was validated and justified through a phantom study showing that the difference between measured (TL dosimeters in the phantom) and derived (TL method) values is within 10%. Six radioimmunotherapy (RIT) patients with widespread intraperitoneal pseudomyxoma were also studied. In dose evaluations, special emphasis was on kidneys. In addition to the TL method, the absorbed doses to kidneys were calculated using MIRD formalism and a point dose kernel technique. We conclude that in SRT the described TL method can be used to estimate the absorbed doses to those critical organs near the body surface within 50% (1 SD).
Aschan
A C
AC
Department of Physics, University of Helsinki, Helsinki University Central Hospital, Finland.
Toivonen
M J
MJ
Lampinen
J S
JS
Tenhunen
M
M
Kairemo
K J
KJ
Korppi-Tommola
E T
ET
Jekunen
A P
AP
Sipilä
P
P
Savolainen
S E
SE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007668:Kidney / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000532:radiotherapy*; D019047:Phantoms, Imaging; D011553:Pseudomyxoma Peritonei / Q000532:radiotherapy*; D011879:Radiotherapy Dosage / Q000592:standards; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation / Q000592:standards*