title: Psychological influences on the perception of immune function.
abstract: BACKGROUND
  Perception of deficiencies in immunity are common in a number of patient complaints. However, little is known about the way in which individuals form perceptions about the competence of their immune system. In two studies we examined the relationship between subjects' perceptions of their immune functioning, physical symptoms, mood and measures of immunity.
  
  
  METHODS
  In Study 1, 20 healthy volunteers completed global ratings of their immune system functioning, as well as mood and symptom reports, twice a week for 5 weeks. At the same time, blood samples were taken to assess serum IgA, IgG, and IgM antibodies. In Study 2, another sample of 58 subjects completed the same measures weekly for 5 weeks and their blood was tested for concentrations of CD3, CD4, CD8, and CD16 lymphocytes.
  
  
  RESULTS
  We found perceptions of immune functioning to be unrelated to the concentrations of serum antibodies or blood lymphocytes. Immune perceptions were strongly related to mood and in particular, feelings of fatigue and vigour. The experience of recent physical symptoms, while not as strong as mood variables, was also important in perceptions of immune functioning.
  
  
  CONCLUSIONS
  Mood seems to be an important determinant in the perception of immune function, and complaints about immune dysfunction in clinical situation should be investigated with this possibility in mind.
authors.affiliation: Department of Psychiatry and Behavioural Science, University of Auckland Faculty of Medicine and Health Science, New Zealand.
authors.forename: K J
authors.initials: KJ
authors.lastname: Petrie
authors.forename: R J
authors.initials: RJ
authors.lastname: Booth
authors.forename: H
authors.initials: H
authors.lastname: Elder
authors.forename: L D
authors.initials: LD
authors.lastname: Cameron
mesh_terms: D000328:Adult; D000339:Affect; D015703:Antigens, CD / Q000097:blood / Q000276:immunology; D001294:Attitude to Health; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D015703:Antigens, CD; D007136:Immunoglobulins