Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of human colon cancer.
A surgical orthotopic implantation (S.O.I.) model of the human colon cancer cell line Co-3 in nude mice was treated with two doses of the new platinum analogs {Pt(cis-dach) (DPPE).2NO3} and {Pt(trans-dach)(DPPE).2NO3}. The analogs were evaluated for antimetastatic efficacy in comparison to two doses of cisplatinum. Unlike the untreated control group, there were no mesenteric lymph node metastases in the groups treated with the high or low doses of both forms of new DPPE platinum analogs as well as cisplatinum-treated group. However, much more body-weight loss occurred in the cisplatinum-treated group than the DPPE-treated groups. The results obtained with SOI animal model of colon cancer demonstrated both cis- and trans-forms of DPPE had as strong an inhibitory effect on metastasis as that of cisplatinum, but with much less toxicity. Thus the new platinum analogs appears to have promising clinical potential.
Rho
Y S
YS
Department of Chemistry, School of Medicine, Kyung Hee University, Seoul, Korea.
Lee
K T
KT
Jung
J C
JC
Yoon
C
C
An
Z
Z
Hoffman
R M
RM
Chang
S G
SG
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C104654:(1,2-bis(diphenylphosphino)ethane)(cis-1,2-diaminocyclohexane)platinum(II); D002945:Cisplatin