title: A rapid and sensitive automated light scattering immunoassay for serum C-reactive protein and the definition of a reference range in healthy blood donors.
abstract: The increasing interest in the measurement of serum C-reactive protein in relation to the risk stratification of patients with chest pain has demonstrated the need for more sensitive routine methods of measurement and an accurate definition of the reference range. We report the determination of a reference range in serum samples from 491 blood donors using a particle enhanced turbidimetric immunoassay that has been modified to offer better imprecision within the reference range. The median values were found to be 2.40 and 2.20 mg/l for males and females, respectively with 95th percentile range of 1.20-5.20 and 0.40-5.40 mg/l, respectively.
authors.affiliation: Department of Clinical Biochemistry, St Bartholomew's, London, UK. c.p.price@mds.qmw.ac.uk
authors.forename: C P
authors.initials: CP
authors.lastname: Price
authors.forename: J
authors.initials: J
authors.lastname: Calvin
authors.forename: S A
authors.initials: SA
authors.lastname: Walker
authors.forename: A
authors.initials: A
authors.lastname: Trull
authors.forename: D J
authors.initials: DJ
authors.lastname: Newman
authors.forename: E G
authors.initials: EG
authors.lastname: Gorman
mesh_terms: D000328:Adult; D001782:Blood Donors; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity
chemical_list: D002097:C-Reactive Protein