The role of insulin-like growth factor I and its receptor in cell growth, transformation, apoptosis, and chemoresistance in solid tumors.
Insulin-like growth factor I (IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activated IGF-I/IGF-IR system displays mitogeneic, transforming, and anti-apoptotic properties in various cell types by stimulating distinct intracellular signaling pathways. Recent data suggest that the anti-apoptotic effect of IGF-I may mediate decreased sensitivity to chemotherapeutic drugs in vitro and in vivo. Thus, targeting the IGF-I/IGF-IR system could serve as an approach to overcome clinical drug resistance in certain tumors.
Grothey
A
A
Abteilung für Hämatologie-Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
Voigt
W
W
Schöber
C
C
Müller
T
T
Dempke
W
W
Schmoll
H J
HJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D017526:Receptor, IGF Type 1 / Q000502:physiology*
D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1