title: ebi regulates epidermal growth factor receptor signaling pathways in Drosophila.
abstract: ebi regulates the epidermal growth factor receptor (EGFR) signaling pathway at multiple steps in Drosophila development. Mutations in ebi and Egfr lead to similar phenotypes and show genetic interactions. However, ebi does not show genetic interactions with other RTKs (e.g., torso) or with components of the canonical Ras/MAP kinase pathway. ebi encodes an evolutionarily conserved protein with a unique amino terminus, distantly related to F-box sequences, and six tandemly arranged carboxy-terminal WD40 repeats. The existence of closely related proteins in yeast, plants, and humans suggests that ebi functions in a highly conserved biochemical pathway. Proteins with related structures regulate protein degradation. Similarly, in the developing eye, ebi promotes EGFR-dependent down-regulation of Tramtrack88, an antagonist of neuronal development.
authors.affiliation: Department of Biological Chemistry, Molecular Biology Institute, The School of Medicine, University of California, Los Angeles, California 90095 USA.
authors.forename: X
authors.initials: X
authors.lastname: Dong
authors.forename: L
authors.initials: L
authors.lastname: Tsuda
authors.forename: K H
authors.initials: KH
authors.lastname: Zavitz
authors.forename: M
authors.initials: M
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: R W
authors.initials: RW
authors.lastname: Carthew
authors.forename: S L
authors.initials: SL
authors.lastname: Zipursky
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018797:Cell Cycle Proteins; D017124:Conserved Sequence; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D066246:ErbB Receptors / Q000378:metabolism*; D019143:Evolution, Molecular; D005123:Eye; D019204:GTP-Binding Proteins; D017344:Genes, Insect; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins; D010641:Phenotype; D015398:Signal Transduction
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; C119014:ebi protein, Drosophila; D066246:ErbB Receptors; D019204:GTP-Binding Proteins