Immunostimulation by plant polyphenols: a relationship between tumor necrosis factor-alpha production and tannin structure.
The ability of the naturally occurring tumoricidal ellagitannin coriariin A to stimulate secretion of both IL-1beta and TNF-alpha from human peripheral blood mononuclear cells has been demonstrated. Companion studies with the monomeric gallotannin beta-D-pentagalloylglucose and a synthesized dimeric gallotannin-ellagitannin hybrid suggest that TNF-alpha rather than IL-1beta is the causative agent in tannin-mediated antitumor action in vivo, in contrast to an ealier proposal.
Feldman
K S
KS
Department of Chemistry, The Pennsylvania State University, University Park 16802, USA.
Sahasrabudhe
K
K
Smith
R S
RS
Scheuchenzuber
W J
WJ
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D005419:Flavonoids; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D011108:Polymers / Q000494:pharmacology*; D059808:Polyphenols; D013634:Tannins / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000276:Adjuvants, Immunologic; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013634:Tannins; D014409:Tumor Necrosis Factor-alpha