title: Changes in lung function between age 8 and 14 years in children with birth weight of less than 1,501 g.
abstract: We set out to determine whether lung function of children with a birth weight of <1,501 g changed relative to expectations between the ages of 8 and 14 years. We hypothesized that changes in lung function may differ between those of birth weight above and below 1,000 g. The subjects of this study were born in the Royal Women's Hospital, Melbourne. There were 86 consecutive survivors with birth weights <1,000 g born between January 1, 1977 and March 31, 1982, and 124 consecutive survivors with birth weights 1,000-1,500 g born between October 1, 1980 and March 31, 1982. Lung function was measured at both age 8 and 14 years, corrected for prematurity in 78% (67/86) of those with birth weight <1,000 g, and in 69% (86/124) of those with birth weight 1,000-1,500 g. Overall, lung function was similar to predicted values at both 8 and 14 years of age [e.g., (forced expired volume in 1 s, FEV1% predicted) at age 8 years mean 88.5% (SD 14.7) and at age 14 years, mean 94.9% (SD 13.8)]. There were significant changes, mostly improvements, in lung function between age 8-14 years relative to predicted values: FEV1 (% predicted) increased between 8-14 years of age by a mean of 6.4 (95% confidence interval, 4.4-8.3). The improvements in some lung function variables were significantly greater in those of birth weight <1,000 g compared with those of birth weight 1,000-1,500 g: improvement in FEV1 (% predicted) between age 8-14 years in infants with birth weight <1,000 g had a mean of 10.3 (SD 13.1), and in those with birthweight 1,000-1,500 g a mean of 3.3 (SD 10.1). We conclude that lung function improved significantly relative to predicted values in children of birth weight <1,501 g between age 8-14 years. The improvements were greatest in those of birth weight <1,000 g.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Melbourne, Australia.
authors.forename: L W
authors.initials: LW
authors.lastname: Doyle
authors.forename: R
authors.initials: R
authors.lastname: Chavasse
authors.forename: G W
authors.initials: GW
authors.lastname: Ford
authors.forename: A
authors.initials: A
authors.lastname: Olinsky
authors.forename: N M
authors.initials: NM
authors.lastname: Davis
authors.forename: C
authors.initials: C
authors.lastname: Callanan
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D001315:Australia; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000254:growth & development*; D008137:Longitudinal Studies; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012129:Respiratory Function Tests