title: Serum lipid and lipoprotein profile in children with iron deficiency anemia.
abstract: BACKGROUND
  A close association has been found between serum lipoprotein abnormalities and the risk of atherosclerosis. In adults, high stored body iron, high serum iron concentrations and low iron binding capacity were found to be risk factors for coronary heart disease. Iron-deficient diets have caused contradictory lipid changes in rats. This report investigates the relationships between iron deficiency, macronutrient intake and the serum lipid and lipoprotein profiles in children with iron deficiency anemia (IDA).
  
  
  RESULTS
  Fifty-six children with IDA, aged 3.0 +/- 1.3 years and 60 healthy age- and sex-matched controls were evaluated. The mean total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), lipoprotein (a) levels and LDL-C/high density lipoprotein cholesterol (HDL-C) and TC/HDL-C ratios of the IDA group were significantly lower than those of controls. While there were no differences in triglycerides and apolipoprotein B (apoB) values between patients and controls, apolipoprotein A-1 (apoA-1) and HDL-C levels were higher in the IDA group. Dietary energy, carbohydrates, total fat and protein intakes of the IDA group were lower than those of controls. After oral iron supplementation, the lipoprotein profile of patients with IDA became similar to controls. In the multivariate analysis, while energy was taken as a covariate, there was no difference in the lipid profile of patients and controls.
  
  
  CONCLUSIONS
  Patients with IDA are also deficient in macronutrients. The low atherogenic serum lipid profile of IDA is not a direct result of iron deficiency itself, but related to decreased energy and protein intakes.
authors.affiliation: Department of Pediatrics, Celal Bayar University, Medical Faculty, Turkey. a_ece@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Ece
authors.forename: M R
authors.initials: MR
authors.lastname: Yiğitoğlu
authors.forename: N
authors.initials: N
authors.lastname: Vurgun
authors.forename: H
authors.initials: H
authors.lastname: Güven
authors.forename: A
authors.initials: A
authors.lastname: Işcan
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood*; D002675:Child, Preschool; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D016555:Matched-Pair Analysis
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D008055:Lipids; D008074:Lipoproteins