Eosinophil development and bone marrow and tissue eosinophils in atopic asthma.
BACKGROUND
Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma.


METHODS
We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmatic and control subjects for expression of the eotaxin receptor, CCR3.


RESULTS
Acquisition of receptors for IL-5 and CCR3 was an early event in eosinophil development. There were increased CD34+ cells, and mature and immature CCR3+ eosinophils in BM from asthmatics.


CONCLUSIONS
These data suggest that IL-5 may act early in eosinophil development, and that eotaxin has the capacity to mobilise a BM eosinophil pool in asthma.
Robinson
D S
DS
Allergy and Clinical Immunology, Imperial College School of Medicine, National Heart and Lung Institute, London, UK. d.s.robinson@ic.ac.uk
North
J
J
Zeibecoglou
K
K
Ying
S
S
Meng
Q
Q
Rankin
S
S
Hamid
Q
Q
Tavernier
J
J
Kay
A B
AB
D018952:Antigens, CD34; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D001854:Bone Marrow Cells / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D002478:Cells, Cultured; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines / Q000276:immunology; D004804:Eosinophils / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015848:Interleukin-5 / Q000276:immunology; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000276:immunology; D018123:Receptors, Interleukin / Q000276:immunology; D053649:Receptors, Interleukin-5
D018952:Antigens, CD34; C515456:CCL11 protein, human; C515350:CCR3 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines; D015848:Interleukin-5; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D018123:Receptors, Interleukin; D053649:Receptors, Interleukin-5