title: The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.
abstract: The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons.
authors.affiliation: Project Group Neuropharmacology, Leibniz Institute for Neurobiology, Magdeburg, Germany. schroede@ifn-magdeburg.de
authors.forename: U H
authors.initials: UH
authors.lastname: Schröder
authors.forename: J
authors.initials: J
authors.lastname: Breder
authors.forename: C F
authors.initials: CF
authors.lastname: Sabelhaus
authors.forename: K G
authors.initials: KG
authors.lastname: Reymann
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007003:Hypoglycemia; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D019831:Sodium-Calcium Exchanger / Q000037:antagonists & inhibitors*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C101670:2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate; D018696:Neuroprotective Agents; D019831:Sodium-Calcium Exchanger; D013890:Thiourea