Recent advances in the fight against leishmaniasis with natural products.
The active compounds obtained from some medicinal plants used traditionally worldwide for the treatment of leishmaniasis are reviewed. Among these active molecules, described in recent literature are quinoline alkaloids such as alkyl-2 quinoline and aryl-2 quinoline from Galipea longiflora, isoquinoline alkaloids such as isoguattouregidine from Guatteria foliosa, indole alkaloids such as conodurine and gabunine from Pescheiera van heurkii, terpenes such as jatrogrossidione from Jatropha grossidentata, acetogenins such as senegalene from Annona senegalensis and lignans such as (+)nyasol from Asparagus africanus. Other natural compounds with antileishmanial activity are coumarins, chalcones, lactones, tetralones and saponins. Some of them are known antiprotozoal natural products. These compounds could be used as templates to discover new and effective drugs against leishmaniasis.
Akendengue
B
B
Département de Chimie-Biochimie, Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon.
Ngou-Milama
E
E
Laurens
A
A
Hocquemiller
R
R
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy*; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000981:Antiprotozoal Agents; D047188:Chalcones; D003374:Coumarins; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; D011809:Quinones; D013729:Terpenes; C112079:isomurisolenin; C059660:squamocin; D002599:Chalcone; C070840:licochalcone A