title: Staphylococcus aureus adhesion to bone matrix and bone-associated biomaterials.
abstract: Staphylococcus aureus is a frequent cause of orthopedic infections in humans. The bacterium expresses several adhesins that facilitate bacterial binding to the bone matrix and to bone implant biomaterials coated with host plasma constituents. The relevant S. aureus adhesins are termed microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) and specific MSCRAMMs are involved in bone and joint infections.
authors.affiliation: Department of Biology, University of North Carolina at Charlotte 28223, USA. mchudson@email.uncc.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Hudson
authors.forename: W K
authors.initials: WK
authors.lastname: Ramp
authors.forename: K P
authors.initials: KP
authors.lastname: Frankenburg
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001422:Bacterial Adhesion; D001672:Biocompatible Materials; D001850:Bone Diseases, Infectious / Q000382:microbiology*; D001857:Bone Matrix / Q000382:microbiology*; D018786:Bone Substitutes; D006801:Humans; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics / Q000502:physiology*
chemical_list: D018829:Adhesins, Bacterial; D001672:Biocompatible Materials; D018786:Bone Substitutes