title: Antibody production in guinea pigs with genetically determined high and low responsiveness to Trichostrongylus colubriformis.
abstract: Antibody levels were compared in guinea pigs with genetically determined differences in their ability to generate protective immunity against the small-intestine nematode parasite Trichostrongylus colubriformis. Animals with the most effective immune response (high responders) developed significantly higher anti-T. colubriformis IgG1 antibody titres than low-responder animals. However, there were no significant differences between their IgG1 antibody responses to a systemically administered protein antigen (ovalbumin). High-titre anti-T. colubriformis serum from high-responder animals did not transfer significant passive protective immunity to low-responder recipients. It is suggested that anti-T. colubriformis IgG1 antibodies mediate the release of mast-cell and basophil products at the site of infection and thus contribute to the more effective immunity expressed by high-responder animals.
authors.affiliation: Department of Veterinary Anatomy and Pathology, The University of Sydney, NSW, Australia.
authors.forename: M H
authors.initials: MH
authors.lastname: Manjili
authors.forename: N C
authors.initials: NC
authors.lastname: Sangster
authors.forename: T L
authors.initials: TL
authors.lastname: Rothwell
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000276:immunology; D006168:Guinea Pigs; D007113:Immunity, Innate; D007114:Immunization; D007132:Immunoglobulin Isotypes / Q000097:blood; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D014253:Trichostrongylosis / Q000276:immunology* / Q000469:parasitology; D014254:Trichostrongylus / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007132:Immunoglobulin Isotypes; D010047:Ovalbumin