title: Acute fatigue in chronic fatigue syndrome patients.
abstract: BACKGROUND
  Chronic fatigue syndrome (CFS) patients often complain that they are more susceptible to acute mental fatigue. It is important to determine whether this is observed using objective tests of sustained attention and responding.
  
  
  METHODS
  Sixty-seven patients who fulfilled the criteria for CFS proposed by Sharpe et al. (1991) were compared with 126 matched healthy controls. Acute fatigue was assessed by comparing performance at the start and end of a lengthy test session and by examining changes over the course of individual tasks.
  
  
  RESULTS
  CFS patients showed impaired performance compared to the controls and these differences increased as the volunteers developed acute fatigue. In addition, differences between the two groups were larger at the end of the test session.
  
  
  CONCLUSIONS
  The present results show that CFS patients are more susceptible to acute fatigue than healthy controls. This could reflect motor fatigue or an inability to compensate for fatigue with increased effort. This profile is consistent with previous research on fatigue and suggests that interpretation of certain aspects of CFS may be helped by considering it as the end point of a continuum of fatigue rather than a distinct disease.
authors.affiliation: Department of Experimental Psychology, University of Bristol.
authors.forename: A P
authors.initials: AP
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Borysiewicz
authors.forename: J
authors.initials: J
authors.lastname: Pollock
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: K
authors.initials: K
authors.lastname: Perry
authors.forename: M
authors.initials: M
authors.lastname: Llewelyn
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002908:Chronic Disease; D003071:Cognition / Q000502:physiology; D005221:Fatigue / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012720:Severity of Illness Index; D012890:Sleep / Q000502:physiology; D011795:Surveys and Questionnaires; D013997:Time Factors