title: Synthetic routes to lipidic diamines and amino alcohols: a class of potential antiinflammatory agents.
abstract: Simple and efficient methods for the synthesis of lipidic amino alcohols and diamines are described in this paper. Lipidic 2-amino alcohols and 1,3-diamines can be synthesized starting from synthetic lipidic alpha-amino acids. Alternatively, commercially available lipidic 1,2-diols may be used as starting material for the synthesis of 2-amino alcohols. Initial experiments on the in vivo antiinflammatory activity of the compounds synthesized gave promising results.
authors.affiliation: Department of Chemistry, University of Athens, Panepistimiopolis, Greece. gkokotos@atlas.uoa.gr
authors.forename: G
authors.initials: G
authors.lastname: Kokotos
authors.forename: V
authors.initials: V
authors.lastname: Constantinou-Kokotou
authors.forename: C
authors.initials: C
authors.lastname: Noula
authors.forename: D
authors.initials: D
authors.lastname: Hadjipavlou-Litina
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000605:Amino Alcohols / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003959:Diamines / Q000138:chemical synthesis*; D004487:Edema / Q000188:drug therapy; D008055:Lipids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D051381:Rats
chemical_list: C119632:1,2-hexadecanediamine; C119631:1,3-heptadecanediamine; D000473:Alkanes; D000588:Amines; D000605:Amino Alcohols; D000893:Anti-Inflammatory Agents; D003959:Diamines; D008055:Lipids