title: Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds.
abstract: Isoxazoline containing RGD mimetics were rapidly synthesized on a solid phase to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alphavbeta3 antagonists.
authors.affiliation: Du Pont Pharmaceuticals Company, Chemical and Physical Sciences Department, Experimental Station, Wilmington, DE 19880-0500, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Rockwell
authors.forename: M
authors.initials: M
authors.lastname: Rafalski
authors.forename: W J
authors.initials: WJ
authors.lastname: Pitts
authors.forename: D G
authors.initials: DG
authors.lastname: Batt
authors.forename: J J
authors.initials: JJ
authors.lastname: Petraitis
authors.forename: W F
authors.initials: WF
authors.lastname: DeGrado
authors.forename: S
authors.initials: S
authors.lastname: Mousa
authors.forename: P K
authors.initials: PK
authors.lastname: Jadhav
mesh_terms: D007555:Isoxazoles / Q000737:chemistry*; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*
chemical_list: D007555:Isoxazoles; D009842:Oligopeptides; D019030:Receptors, Vitronectin; C047981:arginyl-glycyl-aspartic acid