Multi-component methodologies in solid-phase organic synthesis.
Solid-phase organic synthesis, particularly when used in conjunction with combinatorial techniques, is emerging as a revolutionary technology in chemistry. Multi-component reaction systems are particularly valued because several elements of diversity can be introduced in a single transformation thereby expanding the diversity of compound libraries. A variety of multi-component reactions have been successfully adapted for solid-phase technology as described in this review.
Dax
S L
SL
Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.
McNally
J J
JJ
Youngman
M A
MA
D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D013678:Technology, Pharmaceutical / Q000639:trends*