title: Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
abstract: Ornithine decarboxylase (ODC) transgenic and alpha-difluoromethyl ornithine (DFMO)-treated rats were exposed to transient middle cerebral occlusion (MCAO) to examine the role of intraischaemic ODC-activity on the evolution of ischaemia-reperfusion damage. Magnetic resonance imaging (MRI) data show that the damage develops slower in ODC transgenic than in DFMO-treated rats, which is not caused by a difference in perfusion. Furthermore, infarct volumes are smaller in the former animals one day later. These data support the idea of endogenous neuroprotective action of ODC.
authors.affiliation: NMR Research Group, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
authors.forename: J A
authors.initials: JA
authors.lastname: Lukkarinen
authors.forename: O H
authors.initials: OH
authors.lastname: Gröhn
authors.forename: L I
authors.initials: LI
authors.lastname: Alhonen
authors.forename: J
authors.initials: J
authors.lastname: Jänne
authors.forename: R A
authors.initials: RA
authors.lastname: Kauppinen
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000201:enzymology; D001923:Brain Chemistry / Q000235:genetics; D002545:Brain Ischemia / Q000175:diagnosis / Q000201:enzymology*; D002421:Caudate Nucleus / Q000098:blood supply / Q000201:enzymology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000201:enzymology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000201:enzymology*; D018450:Disease Progression; D015971:Gene Expression Regulation, Enzymologic; D008279:Magnetic Resonance Imaging; D009955:Ornithine Decarboxylase / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D019076:Transgenes / Q000502:physiology
chemical_list: D009955:Ornithine Decarboxylase