Haemophilus influenzae has a GM1 ganglioside-like structure and elicits Guillain-Barré syndrome.
The authors report a patient with an axonal Guillain-Barré syndrome (acute motor axonal neuropathy) associated with anti-GM1 antibody after Haemophilus influenzae infection. The result of ELISA inhibition studies and cytochemical staining with cholera toxin suggest the presence of a GM1-like structure on the surface of H. influenzae isolated from the patient. A particular strain of H. influenzae may have a GM1-like structure and may elicit an axonal Guillain-Barré syndrome.
Mori
M
M
Department of Neurology, Chiba University School of Medicine, Japan. morim@olive.ocn.ne.jp
Kuwabara
S
S
Miyake
M
M
Dezawa
M
M
Adachi-Usami
E
E
Kuroki
H
H
Noda
M
M
Hattori
T
T
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005677:G(M1) Ganglioside / Q000276:immunology*; D006192:Haemophilus Infections / Q000150:complications*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D011129:Polyradiculoneuropathy / Q000150:complications / Q000276:immunology* / Q000503:physiopathology
D005677:G(M1) Ganglioside