Repair and mutagenesis survey of 8-hydroxyguanine in bacteria and human cells.
8-Hydroxyguanine is one of the major products formed by the reactive oxygen species which are generated in living cells as a consequence of either the normal metabolic pathways or an exogeneous chemical or physical stress. The production of the oxidative damage is described and the different repair pathways of the oxidative lesions are analyzed from bacteria to human cells. Analysis of repair in human cells harboring different deficiencies in the nucleotide excision repair mechanism such as xeroderma pigmentosum cells from different complementation groups and cells from Cockayne's syndrome patients allows us to emphasize the possibility of the intervention of this repair mechanism on the elimination of oxidative damages. Finally, a repair model of oxidative lesions is proposed.
Le Page
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F
Laboratory of Molecular Genetics, IRC-CNRS-IFR, Y 1221-UPR 42, Villejuif, France.
Gentil
A
A
Sarasin
A
A
D004249:DNA Damage; D004260:DNA Repair; D004926:Escherichia coli / Q000235:genetics*; D006147:Guanine / Q000031:analogs & derivatives* / Q000633:toxicity; D006801:Humans; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity*; D018384:Oxidative Stress
D009153:Mutagens; C024829:8-hydroxyguanine; D006147:Guanine