Learning and anxiety in angiotensin-deficient mice.
Angiotensin II in the brain was shown to be involved in mechanisms influencing cardiovascular and electrolyte homeostasis, anxiety and learning. Here, we report behavioural studies in mice lacking angiotensinogen. We analysed learning and anxiety related behaviour using the Morris water maze task and the elevated plus maze task, respectively. In both tests no differences were found between control mice and angiotensin-deficient mice. This implicates that angiotensin does not influence learning and anxiety-related behaviour in mice under normal conditions.
Walther
T
T
Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany. thowal@mdc-berlin.de
Voigt
J P
JP
Fukamizu
A
A
Fink
H
H
Bader
M
M
D000804:Angiotensin II / Q000172:deficiency / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004924:Escape Reaction / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout
D000804:Angiotensin II