title: Risperidone and clozapine combination for the treatment of refractory schizophrenia.
abstract: Clozapine is the most widely used antipsychotic drug for the treatment of refractory schizophrenia. Here we report the case of two residual schizophrenic patients refractory to conventional antipsychotics who showed a poor response to atypical antipsychotics. The combination of risperidone and clozapine produced a noticeable improvement in the patients' clinical status and a shortening of the treatment response latency.
authors.affiliation: Department of Internal Medicine and Psychiatry, Faculty of Medicine, University of La Laguna, Tenerife, Spain.
authors.forename: A L
authors.initials: AL
authors.lastname: Morera
authors.forename: P
authors.initials: P
authors.lastname: Barreiro
authors.forename: J L
authors.initials: JL
authors.lastname: Cano-Muñoz
mesh_terms: D000328:Adult; D003024:Clozapine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D003024:Clozapine; D018967:Risperidone