Differences in anti-CREG antibody formation between transplanted and nontransplanted renal patients.
BACKGROUND
The aim of this study was investigation of the HLA-I cross-reactive group (CREG)-specific antibodies (Abs) in sera from patients with a failed renal transplant and from nontransplanted patients.


METHODS
A total of 5292 sera from 570 patients awaiting kidney transplantation were screened for the presence of HLA-I CREG-specific Abs. Patients who had never received a transplant (group A), and those with a previous transplant and Abs either not related (group B) or related to donor specificities (group C) were studied. A further division was made for Abs directed against specificities either included in (intra-CREG) or not included in patients' HLA-CREG (extra-CREG).


RESULTS
Twelve of 24 (50%) Abs produced in response to mismatched donor HLA specificities after a failed graft were intra-CREG Abs, compared to 7 of 39 (18%) Abs that were not transplant-related.


CONCLUSIONS
Renal grafts showed a stronger immunogenicity than other sources of allosensitization. Our data also suggest that CREG matching may not be useful for renal allocation.
Fernández-Fresnedo
G
G
Nephrology Unit, University Hospital Marqués de Valdecilla, INSALUD, Santander, Spain.
Pastor
J M
JM
Ruiz
J C
JC
Cotorruelo
J G
JG
Setién
M A
MA
López-Hoyos
M
M
Arias
M
M
D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D012086:Reoperation; D012097:Repressor Proteins / Q000276:immunology*; D017211:Treatment Failure; D014850:Waiting Lists
D000906:Antibodies; C114068:CREG1 protein, human; D006680:HLA Antigens; D012097:Repressor Proteins