title: Hyposthenuria: Sándor Korányi's concept of renal insufficiency.
abstract: Around the turn of the 19th century, the Hungarian physiologist and clinician, Sándor Korányi, started to use physicochemical methods to estimate renal function. In parallel with the deterioration of renal function, he found characteristic changes in the freezing point depression of urine, which he termed hyposthenuria. On the basis of these findings, he was the first to introduce the functional concept of renal insufficiency.
authors.affiliation: First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: S
authors.initials: S
authors.lastname: Sonkodi
mesh_terms: D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D006814:Hungary; D051437:Renal Insufficiency / Q000266:history*