Distribution of two types of mast cells in the nasal mucosa after chemosurgical treatment of allergic rhinitis using trichloroacetic acid.
To evaluate the efficacy of chemosurgery using trichloroacetic acid (TCA) for allergic rhinitis, two types of tissue mast cells [tryptase-positive, chymase-negative mast cells (MCT) and tryptase-positive, chymase-positive mast cells (MCTC)] in the nasal turbinate mucosa were immunohistochemically identified and their distribution was assessed in clinical cases of patients who underwent unilateral TCA treatment. A comparison of the number of MCT and MCTC between the treated and nontreated sides indicates that both types of mast cells are significantly decreased in number in the treated side both in epithelial and lamina propria layers. The results indicate that TCA treatment was effective in suppressing MCT infiltration, regarded as a major cause of antigen-dependent allergy.
Yao
K
K
Department of Otorhinolaryngology, School of Medicine, Kitasato University, Kanagawa, Japan.
Suzuki
T
T
Iguchi
Y
Y
Nishiyama
K
K
Yamamoto
K
K
Okamoto
M
M
D000287:Administration, Topical; D000328:Adult; D002424:Caustics / Q000008:administration & dosage*; D002452:Cell Count; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome; D014238:Trichloroacetic Acid / Q000008:administration & dosage*
D002424:Caustics; D014238:Trichloroacetic Acid