[Parvovirus B19 infection-induced anemia and leukocytopenia after myomectomy].
A 38-year woman was hospitalized because of myoma uteri. She underwent myomectomy on September 30, 1997 with 2,000 ml blood loss. No blood transfusion was required, but she received a plasma protein product. On the 14th postoperative day, a complete blood count revealed anemia (Hb 9.3 g/dl) and leukocytopenia (1,600/ul). But it did not reveal anemia before the operation. Bone marrow smears showed erythroblastopenia with giant proerythroblasts. Anti-parvovirus B19 IgM antibody were positive in the serum and parvovirus B19 DNA was detected in the bone marrow cells by polymerase chain reaction. From the results, the patient was diagnosed as the anemia and leukocytopenia secondary to parvovirus B19 infection. Parvovirus B19 was not detected in the samples of the plasma protein product received on the myomectomy. The reticulocyte gradually decreased to 1/1000 on the 20th postoperative day. The anemia and leukocytopenia gradually improved. This case shows that parvovirus B19 infection could cause hematological disorders in the normal person under acute blood loss. This report warns that a careful observation is necessary for the patients who have received operations with acute blood loss.
Nishiya
K
K
Dept. Clinical Hematology, Osaka City University.
Hino
M
M
Ota
K
K
Yamane
T
T
Takubo
T
T
Tatsumi
N
N
D000328:Adult; D000740:Anemia / Q000209:etiology*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D007970:Leukopenia / Q000209:etiology*; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D011183:Postoperative Complications; D014594:Uterine Neoplasms / Q000601:surgery*