[Quantitative analysis of pulmonary functional damage due to heavy ion particle irradiation therapy for lung cancer].
Seventeen patients with clinical stage I lung cancer were given irradiation therapy with heavy ion radioactive rays at 73.1 +/- 11.2 GyE. Lung injury due to irradiation was evaluated by measuring routing parameters of pulmonary function. No statistically significant changes in these parameters were observed after irradiation, even in patients followed up for a period of 1 year. Chest X-ray examinations, including CT scan images, disclosed the development of nonsegmental consolidations in the irradiated areas, changing into minor fibrosis 1 year later. We concluded that heavy ion particle irradiation has minimal impact on pulmonary function, and is of therapeutic valve to elderly patients and patients with complications.
Homma
T
T
Division of Respiratory Disease, University of Tsukuba, Ibaraki, Japan.
Ohtsu
I
I
Tomioka
S
S
Inoue
M
M
Hasegawa
S
S
Miyamoto
T
T
D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D020450:Heavy Ions; D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D011832:Radiation Injuries / Q000175:diagnosis* / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage