Virus interception of cytokine-regulated pathways.
Cytokines regulate host antiviral, immune and antitumor responses. Viruses combat the host-imposed inhibitory pathways to survive and spread the infection. Some viruses have evolved molecules that override apoptotic programs to promote cell survival until virus assembly is complete, persistence is established or cellular transformation occurs.
Kalvakolanu
D V
DV
Greenebaum Cancer Center, Dept of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. dkalvako@umaryland.edu
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D014764:Viral Proteins / Q000378:metabolism; D014774:Virulence; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*
D016207:Cytokines; D014764:Viral Proteins