title: [Congenital toxoplasmosis and cerebral involvement inspite of prenatal treatment].
abstract: BACKGROUND
  Maternal toxoplasmosis seroconversion during the first trimester of pregnancy raises an important risk of toxoplasmic fetopathy.
  
  
  METHODS
  Primary toxoplasmosis was identified between 9 and 17 weeks of gestation. PCR analysis of the amniotic fluid confirmed fetal infection. The mother was given a sulfadoxine-piremythamine combination and monthly ultrasonographic surveillance was initiated. At birth, the female infant was found to have diffuse cortical lesions and a chorioretinitis compatible with toxoplasmic fetopathy. She was given sulfadoxine-piremythamine. At 2 years, the clinical and neuroradiological course has been favorable.
  
  
  CONCLUSIONS
  Despite antenatal and postnatal treatment and despite ultrasonographic surveillance, it is difficult to predict the course of congenital toxoplasmosis. This case illustrates the importance of informing parents of the risk and the requirement for careful follow-up after antenatal diagnosis of first-trimester toxoplasmosis.
authors.affiliation: Service de Médecine infantile, Hôpital Nord, Marseille. c.gire@aphm.fr
authors.forename: C
authors.initials: C
authors.lastname: Gire
authors.forename: C
authors.initials: C
authors.lastname: Nicaise
authors.forename: P
authors.initials: P
authors.lastname: Minodier
authors.forename: C
authors.initials: C
authors.lastname: Palix
authors.forename: L
authors.initials: L
authors.lastname: Boubli
authors.forename: J M
authors.initials: JM
authors.lastname: Garnier
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis*; D011261:Pregnancy Trimester, First; D011295:Prenatal Care; D012307:Risk Factors; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000635:transmission; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis*; D016216:Ultrasonography, Prenatal