Adenosine receptor ligands with oxygenated N6-substituents.
A number of novel adenosine analogs bearing oxygenated substituents in the N6-position have been prepared and evaluated as A1 adenosine agonists. Improved conditions for the synthesis of N6-substituted adenosines and a new one pot procedure for the synthesis of 2-amino-7-oxabicyclo[2.2.1]hept-5-ene are also reported.
Hutchinson
S A
SA
School of Biological & Chemical Sciences, Deakin University, Geelong, Vic, Australia.
Baker
S P
SP
Scammells
P J
PJ
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D010100:Oxygen / Q000737:chemistry; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1 / Q000378:metabolism
C119485:2-amino-7-oxabicyclo(2.2.1)hept-5-ene; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008024:Ligands; D058906:Purinergic P1 Receptor Agonists; D018047:Receptors, Purinergic P1; D010100:Oxygen