title: Comparison of the effects of sevoflurane and isoflurane on arterial oxygenation during one lung ventilation.
abstract: We have compared the effects of sevoflurane and isoflurane on arterial oxygenation, heart rate and mean arterial pressure during one lung anaesthesia in a prospective, crossover study. We studied 28 patients undergoing oesophagogastrectomy, allocated alternatively to one of two groups. Patients in group I/S (n = 14) received 1 MAC (1.1%) of isoflurane in oxygen from induction until the end of 30 min of open chest one lung ventilation (OLV) in the lateral position. This was followed by 1 MAC (2.1%) of sevoflurane in oxygen for the next 30 min of OLV. Patients in group S/I (n = 14) received the two anaesthetic agents in the reverse order. We found no significant difference in arterial oxygenation, heart rate or mean arterial pressure between the two potent inhalation agents. In the subgroup of patients with pulmonary artery catheters (n = 12), we found a significant increase (P < 0.05) in derived shunt during sevoflurane anaesthesia. There was no significant difference in mixed venous saturation and cardiac output. We conclude that during one lung ventilation, the choice between sevoflurane and isoflurane did not significantly influence arterial oxygenation.
authors.affiliation: Cardiothoracic Centre, Liverpool.
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: G N
authors.initials: GN
authors.lastname: Russell
authors.forename: R D
authors.initials: RD
authors.lastname: Page
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: S H
authors.initials: SH
authors.lastname: Pennefather
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001158:Arteries; D018592:Cross-Over Studies; D016629:Esophagectomy; D005260:Female; D005743:Gastrectomy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D010100:Oxygen