[Spontaneous menstruation in patients with Turner syndrome in our observations].
OBJECTIVE
Patients with Turner syndrome (TS) may present a wide spectrum of gonadal function including spontaneous menstruation and fertility.


METHODS
The aim of our study was to present the patients with Turner syndrome (TS) with spontaneous menstruations considering specific karyotype and X-inactivation processes.


METHODS
5 women from group of 55 patients in age from 15 to 38 years with diagnosis of TS and gonadal function were found. Clinical analysis included the evaluation of spontaneous pubertal development and hormones levels. Cytogenetic analysis was performed on peripheral blood samples using GTG banding technique. X inactivation studies were done by dynamic RBG technique.


RESULTS
In two patients with mosaic karyotype and predominant 46,XX line two pregnancies were observed. They had regular menses and normal sexual development. In one patient (karyotype: 45,X[2]/46,XX[98]) spontaneous abortions and premature birth were present. Second patient was (46,XX[245]/46,X,r(X)(p22q26)[5]) in pregnancy in this time. Another three patients menstruated irregularly. The menarche appeared later. The karyotypes were: 46,X,del(X)(p11.3) in two patients and 45,X[64]46,X,r(X) (p22q26)[18]/46,XX[4] in one.


CONCLUSIONS
We conclude that spontaneous menstruations and possibility of pregnancy depend on specific karyotype in patients with TS.
Leśniewicz
R
R
Zakładu Genetyki Klinicznej Instytutu Połoznictwa i Chorób Kobiecych Akademii Medycznej w Białymstoku.
Panasiuk
B
B
Midro
A T
AT
D000293:Adolescent; D000328:Adult; D004303:Dosage Compensation, Genetic; D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D008598:Menstruation / Q000502:physiology*; D014424:Turner Syndrome / Q000175:diagnosis* / Q000235:genetics*