Allogeneic bone marrow transplantation for advanced Waldenstrom's macroglobulinemia.
Waldenstrom's disease is a lymphoproliferative disorder that is typically treated with plasmapheresis and/or alkylating agents. In young patients, other lymphoproliferative disorders have been treated with allogeneic transplantation. Two patients with aggressive Waldenstrom's disease, who progressed in spite of multi-agent chemotherapy and autologous stem cell transplantation, in one case, underwent allogeneic transplantation from their HLA-identical donors. Both remain alive with event-free survivals of more than 3, and more than 9 years, respectively. Allogeneic transplantation should be considered for young patients with Waldenstrom's disease.
Martino
R
R
Clinical Hematology Division, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Shah
A
A
Romero
P
P
Brunet
S
S
Sierra
J
J
Domingo-Albós
A
A
Fruchtman
S
S
Isola
L
L
D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D008297:Male; D014184:Transplantation, Homologous; D008258:Waldenstrom Macroglobulinemia / Q000628:therapy*