HIV-1 attachment: another look.
HIV-1 attachment to host cells is generally considered to take place via high-affinity binding between CD4 and gp120. However, the binding of virion-associated gp120 to cellular CD4 is often weak, and most cell types that are permissive for HIV-1 infection express little CD4. Thus, other interactions between the virion and the cell surface could dominate the attachment process.
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Centre d'Immunologie de Marseille-Luminy, 163 Avenue de Luminy, Case 906, 13288 Marseille Cedex 9, France.
Mondor
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Sattentau
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D015704:CD4 Antigens / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000378:metabolism* / Q000472:pathogenicity*; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D019713:Receptors, CCR5 / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*
D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D015699:HIV Envelope Protein gp120; D019812:Heparan Sulfate Proteoglycans; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D011956:Receptors, Cell Surface