Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.
The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function.
Carlyle
J R
JR
Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada.
Martin
A
A
Mehra
A
A
Attisano
L
L
Tsui
F W
FW
Zúñiga-Pflücker
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000235:genetics / Q000378:metabolism*; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000235:genetics / Q000378:metabolism*; D001773:Blood Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005312:Fetal Blood / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology*; D037181:Lectins, C-Type; D051379:Mice; D008810:Mice, Inbred C57BL; D018448:Models, Immunological; D008969:Molecular Sequence Data; D005810:Multigene Family; D055651:NK Cell Lectin-Like Receptor Subfamily B; D010766:Phosphorylation; D011485:Protein Binding; D054645:Protein Phosphatase 1; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D018909:src Homology Domains
D000941:Antigens; D000950:Antigens, Ly; D000954:Antigens, Surface; D047908:Intracellular Signaling Peptides and Proteins; C527211:Klrb1c protein, mouse; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011506:Proteins; D011971:Receptors, Immunologic; D054645:Protein Phosphatase 1; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases; C516725:Ptpn11 protein, mouse; C509248:Ptpn6 protein, mouse; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases