title: Appearance of severe jaundice after radiometabolical treatment of thyrotoxicosis.
abstract: The appearance of moderate jaundice with mildly raised levels of plasma bilirubin is an uncommon complication of thyrotoxicosis and is usually accompanied by signs of right heart failure. Some described cases were actually related, at least in part, to autoimmune chronic hepatitis. In this paper we describe a case of thyrotoxicosis accompanied by deep jaundice with very high levels of bilirubin occuring in the absence of cardiac failure and with no signs of hepatitis. Jaundice disappeared shortly after the start of thyrostatic drug treatment, supporting a possible detrimental effect of hyperthyroidism on the hepatic bilirubin metabolism.
authors.affiliation: U.O. di Medicina Interna, Ospedale Civile di Cuorgnè, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Babini
authors.forename: L
authors.initials: L
authors.lastname: Gurioli
authors.forename: R
authors.initials: R
authors.lastname: Rizzi
authors.forename: P
authors.initials: P
authors.lastname: Bertello
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D013956:Antithyroid Agents / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008713:Methimazole / Q000627:therapeutic use*; D008875:Middle Aged; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications* / Q000628:therapy; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D013956:Antithyroid Agents; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D008713:Methimazole; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D013974:Thyroxine; D001663:Bilirubin