Comparative study on the effect of cyclic nucleotides related to the function of Biomphalaria glabrata hemocytes and human granulocytes.
The biochemical processes linked up to cyclic nucleotides related to the phenomenon of phagocytosis in Biomphalaria glabrata hemocytes were studied. In hemocytes the results suggest the presence of a phagocytic capacity similar to that observed in human cells related to regulation by cyclic adenylate monophosphate (cAMP), but not by cyclic guanylate monophosphate (cGMP). This similarity and differences in the metabolic process of phagocytary capacity between human phagocytary cells and hemocytes could represent an interesting model aimed at studying the phylogenetic evolution of enzymatic complexes.
Bezerra
F S
FS
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, Brazil.
Coelho
P M
PM
Chaves
M M
MM
Martins
R L
RL
Nogueira-Machado
J A
JA
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001700:Biomphalaria / Q000276:immunology* / Q000469:parasitology; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D006152:Cyclic GMP / Q000378:metabolism* / Q000494:pharmacology; D006098:Granulocytes / Q000276:immunology* / Q000378:metabolism; D006434:Hemocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010587:Phagocytosis; D012550:Schistosoma mansoni / Q000276:immunology; D015054:Zymosan / Q000494:pharmacology
D000628:Aminophylline; D015054:Zymosan; D000242:Cyclic AMP; D006152:Cyclic GMP