title: An increase in vitamin A status by the feeding of conjugated linoleic acid.
abstract: Previous research indicated that conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. The present study showed a progressive increase in retinol (vitamin A alcohol) in the liver in proportion to CLA intake in rats that were fed different levels of CLA (in increments of 0.5%) for 1 month. The escalation reached a magnitude of about fivefold over the control at 2% dietary CLA. In contrast, the increase in liver retinyl esters peaked at about twofold between 0.5% and 1% CLA. Only retinol was detected in mammary tissue; a maximal twofold increase was attained at 0.5% CLA, and no dose-response effect was evident. The above findings are discussed in relation to two important questions: 1) How does CLA raise vitamin A status in the animal? 2) Is the increase in vitamin A associated with the anticarcinogenic effect of CLA?
authors.affiliation: Dipartimento di Biologia Sperimentale, Universitale degli Studi di Cagliari, Cittadella Universitaria, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Banni
authors.forename: E
authors.initials: E
authors.lastname: Angioni
authors.forename: V
authors.initials: V
authors.lastname: Casu
authors.forename: M P
authors.initials: MP
authors.lastname: Melis
authors.forename: S
authors.initials: S
authors.lastname: Scrugli
authors.forename: G
authors.initials: G
authors.lastname: Carta
authors.forename: F P
authors.initials: FP
authors.lastname: Corongiu
authors.forename: C
authors.initials: C
authors.lastname: Ip
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D005260:Female; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013047:Specific Pathogen-Free Organisms; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
chemical_list: D014801:Vitamin A; D019787:Linoleic Acid