HIV combination therapy: immune restitution causing cryptococcal lymphadenitis dramatically improved by anti-inflammatory therapy.
Two patients with AIDS developed microscopically verified focal cryptococcal lymphadenitis while treated with highly active anti-retroviral therapy for 8 and 15 months. Both were treated with fluconazole as a secondary prophylaxis for prior cryptococcal meningitis. Cryptococcus neoformans did not grow. Amphotericin was ineffective. Anti-inflammatory drugs had a dramatic effect.
Blanche
P
P
Service de Médecine Interne 2, Hôpital Cochin, Université René Descartes, Paris, France.
Gombert
B
B
Ginsburg
C
C
Passeron
A
A
Stubei
I
I
Rigolet
A
A
Salmon
D
D
Sicard
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000188:drug therapy / Q000209:etiology*; D015725:Fluconazole / Q000627:therapeutic use; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008199:Lymphadenitis / Q000188:drug therapy / Q000209:etiology*; D008297:Male
D000893:Anti-Inflammatory Agents; D017320:HIV Protease Inhibitors; D015725:Fluconazole