Increased serum CA 19-9 antibodies in Sjögren's syndrome.
A 67-year-old woman with a history of thyroiditis presented with recent intermittent epigastric pain and nausea. Hyperamylasaemia, oedema of the pancreas, and high serum levels of lipase and CA 19-9 were found. Xerostomia and dry eyes developed later, accompanied by an abnormal Schirmer's test. The diagnosis of Sjögren's syndrome was confirmed by increased anti-Ro and anti-La antibodies and the histological findings of parotid gland biopsy. Two additional cases of Sjögren's syndrome with elevated serum CA 19-9 are also described. These observations of elevated serum lipase and serum CA 19-9 in Sjögren's syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder.
Safadi
R
R
Gastroenterology Unit, Hebrew University School of Medicine, Jerusalem, Israel.
Ligumsky
M
M
Goldin
E
E
Ilan
Y
Y
Haviv
Y S
YS
Nusair
S
S
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D018395:CA-19-9 Antigen / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000276:immunology*
D000906:Antibodies; D018395:CA-19-9 Antigen