title: Dopamine D2 receptor promoter polymorphism: no association with schizophrenia.
abstract: A functional polymorphism in the promoter region of the dopamine D2 receptor gene, the -141C Del allele, which may be associated with schizophrenia susceptibility, has previously been described in a Japanese sample. The present study was done in order to examine whether such an association would also be found in a North American schizophrenia patient population. However, analysis of the -141C Del allele frequency in the present group of schizophrenia patients (n = 50) and control subjects (n = 51) did not identify any significant differences. These data support the recent reports on German and British subjects that this genetic variation in the 5'-flanking region of the dopamine D2 receptor gene does not play a major role in the genetic predisposition to schizophrenia.
authors.affiliation: Department of Psychiatry, University of Toronto, Ontario, Canada. t.tallerico@utoronto.ca
authors.forename: T
authors.initials: T
authors.lastname: Tallerico
authors.forename: C
authors.initials: C
authors.lastname: Ulpian
authors.forename: I S
authors.initials: IS
authors.lastname: Liu
mesh_terms: D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2