title: [A case of chronic myelogenous leukemia presenting multiple extramedullary tumors localized in cranial dura].
abstract: A 64-year-old woman had been given a diagnosis of Ph-positive chronic myelogenous leukemia (Ph+ CML) in October 1992 and accordingly treated with interferon-alpha busulfan, and hydroxyurea. She was admitted to our hospital with a one-day history of consciousness disturbance on May 30, 1993. Two weeks before admission, she had received chemotherapy consisting of vincristine and predonisolone because of progressive thrombocytopenia, basophilia, and leukocytosis accompanied by a heightened degree of cell immaturity in peripheral blood and bone marrow. Cranial computerized tomography on admission disclosed tumoral masses in the left frontal lobe and the right temporal lobe. Moreover, lumbar puncture ezinkns disclosed blastoid cells in cerebrospinal fluid. Based on these laboratory findings, the diagnosis was blastic crisis CML, 46XX t(9; 22; 17) (q34; q11; q23), cytogenetic aberration and extramedulary brain disease Although the patient underwent the same combined chemotherapy again, her unconsciousness did not resolve. She died of cerebellar herniation on the 7th hospital day. Post mortem examination revealed three extramedullary tumors localized in cranial dura. This was a rare case of CML presenting multiple extramedullary tumors localized in cranial dura.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: I
authors.initials: I
authors.lastname: Tsuboi
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: S
authors.initials: S
authors.lastname: Aikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneita
authors.forename: T
authors.initials: T
authors.lastname: Ohsima
authors.forename: U
authors.initials: U
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Horie
mesh_terms: D001752:Blast Crisis / Q000473:pathology*; D002526:Cerebellar Diseases / Q000209:etiology; D002540:Cerebral Cortex / Q000473:pathology*; D002869:Chromosome Aberrations; D004388:Dura Mater / Q000473:pathology; D004677:Encephalocele / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged