title: A case of anaplastic thyroid carcinoma surviving disease free for over 2 years.
abstract: A 52-year female presented with an enlarged thyroid mass and lump sensation in the throat. The cytologic examination showed class five and she was admitted to the hospital to undergo operation. Total thyroidectomy was done and the tumoral invasion of the trachea was removed. We performed tracheoplasty using a sternocleidomastoid muscle-clavicle myoosseous flap in a single stage operation. Histologic diagnosis revealed anaplastic thyroid carcinoma After upper mediastinal dissection had been performed, systemic chemotherapy using pirarubicin, cisplatin and etoposide was administered. In addition, she was treated with radiochemotherapy using pirarubicin, cisplatin and a total of 58 Gy was administered. No recurrence of the tumor has been noted since the above operation 2 years ago. Immunohistochemical studies of primary and metastatic tissues in this case revealed a positive expression of p53 protein in both.
authors.affiliation: Department of Otolaryngology, Sapporo Medical University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanaseki
authors.forename: Y
authors.initials: Y
authors.lastname: Harabuchi
authors.forename: J
authors.initials: J
authors.lastname: Wakashima
authors.forename: K
authors.initials: K
authors.lastname: Asakura
authors.forename: A
authors.initials: A
authors.lastname: Kataura
authors.forename: M
authors.initials: M
authors.lastname: Satoh
mesh_terms: D001707:Biopsy, Needle; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D013524:Surgical Flaps; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy