Efficacy of two dose measles vaccination in a community setting.
OBJECTIVE
To compare the efficacy of two dose and single dose measles vaccination in a community setting.


METHODS
Two community ICDS blocks with populations of 8990 and 8550 children below 12 years of age were selected. Block A had 1560 children between 9 mo to 1 year of age and Block B had 1380 children between the age of 9 mo to 1 year.


METHODS
All eligible children between 9 mo to 1 year of age were given measles vaccination in October 1994. Only the children in Group A were given a second dose of measles (as MMR) in April 1995; six months after the first dose. A survey was undertaken from January 1996 to April 1996 to clinically evaluate the number of cases of measles in both these blocks.


RESULTS
In Block A 3 children developed measles, whereas in Block B, there were 16 cases of measles (p < 0.01). All other parameters in both groups, e.g., cold chain maintenance were similar.


CONCLUSIONS
This study supports the superiority of two dose measles vaccination given at an interval of 6 months over a single dose measles in a community setting.
Phadke
M A
MA
Department of Pediatrics, B.J. Medical College, Pune, India.
Bhargava
I
I
Dhaigude
P
P
Bagade
A
A
Biniwale
M A
MA
Kurlekar
S U
SU
D016022:Case-Control Studies; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D015994:Incidence; D007223:Infant; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage*; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000008:administration & dosage; D012411:Rubella Vaccine / Q000008:administration & dosage; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage
D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined