Role of interleukin-2 in pancreatic islet-cell destruction in reovirus type 2-infected DBA/1 suckling mice.
Reovirus type 2 (Reo-2)-infected DBA/1 suckling mice develop insulitis, resulting in a diabetes-like syndrome. In this study, the role of interleukin-2 (IL-2) in the death (destruction) of pancreatic islet cells was examined. The endogenous IL-2 activity of splenic cells in infected mice was greater than that in uninfected mice. Treatment of infected mice with monoclonal antibody against IL-2 prevented the development of insulitis with impaired glucose tolerance, in a dose-dependent manner. These results suggest that IL-2 may participate in pancreatic islet-cell destruction in Reo-2-induced diabetes-like syndrome.
Hayashi
T
T
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yoshida, Yamaguchi, 753-8515, Japan.
Iwata
H
H
Onodera
T
T
D000818:Animals; D000833:Animals, Suckling; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016923:Cell Death; D002478:Cells, Cultured; D003922:Diabetes Mellitus, Type 1 / Q000821:virology*; D005951:Glucose Tolerance Test; D007376:Interleukin-2 / Q000276:immunology / Q000502:physiology*; D007515:Islets of Langerhans / Q000821:virology*; D051379:Mice; D008811:Mice, Inbred DBA; D018165:Orthoreovirus / Q000502:physiology; D012088:Reoviridae Infections / Q000473:pathology / Q000821:virology*; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D007376:Interleukin-2