title: 10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis.
abstract: Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro.
authors.affiliation: Laboratory of Pharmacognosy, Institute of Pharmacy, University of Liège, CHU, Tour 4, Avenue de l'Hôpital 1, B-4000 Liège, Belgium. M.Frederich@ulg.ac.be
authors.forename: M
authors.initials: M
authors.lastname: Frédérich
authors.forename: M
authors.initials: M
authors.lastname: Tits
authors.forename: M P
authors.initials: MP
authors.lastname: Hayette
authors.forename: V
authors.initials: V
authors.lastname: Brandt
authors.forename: J
authors.initials: J
authors.lastname: Penelle
authors.forename: P
authors.initials: P
authors.lastname: DeMol
authors.forename: G
authors.initials: G
authors.lastname: Llabrès
authors.forename: L
authors.initials: L
authors.lastname: Angenot
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012432:Rwanda; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013636:Tanzania
chemical_list: C119461:10'-hydroxyusambarensine; D000470:Alkaloids; D000962:Antimalarials; D007211:Indoles