title: Squamous cell carcinoma-related antigen (SCCr-Ag), sICAM-1 and beta 2-microglobulin are useful markers of disease activity in psoriasis.
abstract: Several published studies suggest the involvement of immune and inflammatory factors in psoriasis. We recently demonstrated that the number of circulating ICAM-1 + lymphocytes and the levels beta 2-microglobulin are useful parameters in monitoring the activity of the disease. In this study we investigated serum levels of SCCr-Ag in 24 patients with psoriasis in order to determine whether this antigen is a marker of disease activity. Our results demonstrated high serum levels of SCCr-Ag, IL-2, sIL-2R, sCD4, sCD8, sICAM-1 and beta 2-microglobulin in the acute phase of psoriasis. Furthermore, we found a positive correlation of SCC with TBSA, PASI score, sICAM-1 and beta 2-microglobulin. These data demonstrate that serum levels of SCCr-Ag depend on the severity of the disease and correlate with both immunological and inflammatory markers of disease activity. We suggest that expression of SCCr-Ag may be induced by cytokines in the microenvironment of psoriatic lesions, suggesting that SCC-Ag may play a role in the inflammatory process.
authors.affiliation: Department of Immunodermatology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
authors.forename: O
authors.initials: O
authors.lastname: De Pità
authors.forename: A
authors.initials: A
authors.lastname: Frezzolini
authors.forename: A
authors.initials: A
authors.lastname: Cianetti
authors.forename: G
authors.initials: G
authors.lastname: De Sanctis
authors.forename: L
authors.initials: L
authors.lastname: Fontana
authors.forename: V
authors.initials: V
authors.lastname: Bottari
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001830:Body Surface Area; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007633:Keratins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000276:immunology*; D015843:Serpins; D012720:Severity of Illness Index; D001613:beta 2-Microglobulin / Q000378:metabolism*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D016207:Cytokines; D015843:Serpins; D001613:beta 2-Microglobulin; C051072:squamous cell carcinoma-related antigen; D018799:Intercellular Adhesion Molecule-1; D007633:Keratins