Delayed manifestation of ultra violet radiation induced erythema in guinea pigs by sodium pyruvate--a free radical scavenger.
Sodium pyruvate, a free radical scavenger was evaluated for anti-inflammatory activity using UV radiation induced dermal erythema on guinea pig and compared with that of standard naproxen. Oral as well as topical pyruvate exhibited significant activity against UV induced dermal erythema model and the activity was comparable to that of naproxen. In the other pharmacodynamic studies, such as the studies on rat blood pressure, isolated guinea pig ileum and rat uterus, it showed no effect on any of these. In conclusion, sodium pyruvate showed a significant protection in the UV induced dermal erythema in guinea pigs. It also showed good absorption in UV-B range and this property can be utilised to develop the sodium pyruvate as a sunscreening agent.
Gupta
S K
SK
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Awor
L
L
Rastogi
S
S
Prakash
J
J
Gupta
Y K
YK
Varma
S D
SD
Velpandian
T
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004890:Erythema / Q000209:etiology* / Q000517:prevention & control*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006168:Guinea Pigs; D009288:Naproxen / Q000627:therapeutic use; D019289:Pyruvic Acid / Q000627:therapeutic use*; D013473:Sunscreening Agents / Q000627:therapeutic use; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016166:Free Radical Scavengers; D013473:Sunscreening Agents; D009288:Naproxen; D019289:Pyruvic Acid