Diuretic effect of phosphodiesterase inhibitors depends on baseline renal function in patients with congestive heart failure.
We examined the diuretic effects of phosphodiesterase inhibitors in heart failure patients with and without renal failure. We found that, despite the improvement in central hemodynamics, phosphodiesterase inhibitors do not necessarily facilitate diuresis in heart failure in patients with concomitant renal failure.
Kanda
M
M
Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
Yasuda
S
S
Goto
Y
Y
Sumida
H
H
Baba
T
T
Noguchi
T
T
Nonogi
H
H
D000368:Aged; D000369:Aged, 80 and over; D000676:Amrinone / Q000008:administration & dosage / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000008:administration & dosage / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011728:Pyridones / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome
D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; C059498:olprinone; D003404:Creatinine; D020105:Milrinone; D000676:Amrinone