Diffuse alveolar damage in BCGosis: a rare complication of intravesical bacillus Calmette-Guérin therapy for transitional cell carcinoma.
Intravesical administration of bacillus Calmette-Guérin is a relatively simple procedure used in the treatment of superficial transitional cell carcinoma of the urinary bladder. It is usually well tolerated with few major side effects. In rare instances, systemic complications can result in death. The usual autopsy finding is that of caseating and non-caseating granulomata in the affected organ. We report the second case of BCGosis in which granulomata together with acute and organising phase diffuse alveolar damage were found in the lungs.
Tan
L
L
Department of Tissue Pathology, Westmead Hospital, New South Wales, Australia.
Testa
G
G
Yung
T
T
D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects*; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D017809:Fatal Outcome; D015769:Granuloma, Respiratory Tract / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008297:Male; D011650:Pulmonary Alveoli / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000628:therapy
D001500:BCG Vaccine