Microtubule motors in spindle and chromosome motility.
Many of the kinesin microtubule motor proteins discovered during the past 8-9 years have roles in spindle assembly and function or chromosome movement during meiosis or mitosis. The discovery of kinesin motor proteins with a clear involvement in spindle and chromosome motility, together with recent evidence that cytoplasmic dynein plays a role in chromosome distribution, has attracted great interest. The identification of microtubule motors that function in chromosome distribution represents a major advance in understanding the forces that underlie chromosome and spindle movements during cell division.
Endow
S A
SA
Department of Microbiology, Duke University Medical Center, Durham, NC USA. endow@galactose.mc.duke.edu
D000818:Animals; D002875:Chromosomes; D006801:Humans; D016547:Kinesins / Q000502:physiology*; D008941:Spindle Apparatus
D016547:Kinesins