The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes.
The mammalian genome encodes numerous autosomal minor histocompatibilty (H) antigens that act as a barrier to allogeneic tissue transplantation when donor and recipient are matched for the major histocompatibilty complex (MHC). However, most of our understanding of the genetic basis of such minor H antigens is limited to analysis of mouse strains of the H2b haplotype. To broaden our understanding, we investigated minor H antigens detected in the context of other MHC alleles. As measured by graft survival and precursor cytotoxic T lymphocytes from blood, our results suggest that chromosomal segments known to encode minor H antigens detected in the context of the H2b haplotype are antigenically complex in that they also frequently encode minor H antigens that can be detected in the context of at least the H2d and H2k haplotypes. Genetic models to account for this complexity are discussed.
Klinge
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The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Roopenian
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D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000235:genetics / Q000276:immunology; D002875:Chromosomes / Q000235:genetics; D000939:Epitopes / Q000235:genetics; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006239:Haplotypes / Q000235:genetics*; D007114:Immunization; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000942:Antigens, Bacterial; D000939:Epitopes; C022863:H antigen; D015778:Minor Histocompatibility Antigens