Effects of some N-nitropyrazole derivatives on ocular blood flow and retinal function recovery after ischemic insult.
Ocular blood flow and retinal function were determined in this study with colored microspheres and b-wave amplitude of electroretinography, respectively. It was found that N-nitropyrazole analogs can facilitate the retinal function recovery efficiently after ischemic insult primarily through increase of choroidal blood flow specifically. Since age-related macular degeneration (AMD) is caused mainly by the choroidal vascular abnormality and/or insufficiency, these N-nitropyrazole analogs are of potential use in the treatment of AMD.
Xuan
B
B
Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, Texas A&M University College of Medicine, College Station 77843-1114, USA.
Zhou
Y H
YH
Varma
R
R
Chiou
G C
GC
D000818:Animals; D005123:Eye / Q000098:blood supply*; D005260:Female; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D008268:Macular Degeneration / Q000188:drug therapy*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D020318:Rats, Long-Evans; D012039:Regional Blood Flow / Q000187:drug effects; D012160:Retina / Q000187:drug effects* / Q000502:physiology
D020030:Nitric Oxide Donors; D011720:Pyrazoles