FGF7 protein expression in human breast carcinomas.
FGFs, especially FGF7, are thought to play an important role in the stroma-epithelium interactions that take place in several tissues, including the prostate and mammary glands. Using an immunohistochemistry approach, FGF7 protein expression was measured in a series of 80 human breast carcinomas. FGF7 was found to be expressed in two-thirds of cases studied, either in the stroma or in the tumour cells. Although it did not reach significance level, a tendency was noted for FGF7 expression to be associated with the most differentiated and least aggressive tumours.
Jacquemier
J
J
Département de Pathologie, Institut Paoli-Calmettes, Marseille, France.
Sun
Z Z
ZZ
Penault-Llorca
F
F
Geneix
J
J
Devilard
E
E
Adélaïde
J
J
Birnbaum
D
D
D000911:Antibodies, Monoclonal; D015153:Blotting, Western; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000401:mortality; D016009:Chi-Square Distribution; D005260:Female; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D015996:Survival Rate
D000911:Antibodies, Monoclonal; C496453:FGF7 protein, human; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors