Steroids treatment of granulomatous hepatitis complicating Coxiella burnetii acute infection.
Granulomatous hepatitis associated with Coxiella burnetii acute infection has an adverse clinical course in some patients. Surprisingly, it does not respond to antibiotic but to steroids treatment. A hypersensitivity mechanism has been implicated. A case of granulomatous hepatitis complicating C. burnetii acute infection is reported, which was refractory to antibiotics but, as in four other cases previously reported, showed a complete response to steroids. This case was found to support findings that moderate doses of steroids can be useful in patients with granulomatous hepatitis complicating C. burnetii infection and showing no response to antibiotic treatment.
Crespo
M
M
Hospital Xeral-Cíes, Servicio de la Medicina Interna, Vigo, Spain.
Sopeña
B
B
Bordón
J
J
de la Fuente
J
J
Rubianes
M
M
Martinez-Vázquez
C
C
D000208:Acute Disease; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000150:complications / Q000188:drug therapy*; D006505:Hepatitis / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D011778:Q Fever / Q000150:complications / Q000188:drug therapy*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D002939:Ciprofloxacin; D004318:Doxycycline; D011241:Prednisone