Low-density lipoprotein apheresis for focal glomerular sclerosis.
We report on a 22-year-old female with focal glomerular sclerosis and hyperlipidemia who did not respond to long-term steroid or immunosuppressant therapy. When low-density lipoprotein (LDL) apheresis was performed, her total daily protein excretion decreased, serum albumin increased, total cholesterol decreased from 1,052 mg/dl to 148 mg/dl after 3 months, and the serum lipoprotein(a) level also decreased from 117.8 mg/dl to 9.1 mg/dl. After this therapy, her clinical course was well maintained. By controlling hyperlipidemia, including oxidized low-density lipoprotein and lipoprotein(a), low-density lipoprotein apheresis may produce clinical improvement in focal glomerular sclerosis.
Yorioka
N
N
Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Taniguchi
Y
Y
Nishida
Y
Y
Okushin
S
S
Amimoto
D
D
Yamakido
M
M
D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000628:therapy*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D010956:Plasmapheresis
D008077:Lipoproteins, LDL; D003404:Creatinine