title: [Hyperglobulinemia E syndrome with recurrent infections (Job's syndrome)].
abstract: BACKGROUND
  To provide definition and nosology of hyperimmunoglobulinemia E previously termed Job's syndrome or Buckleys' syndrome in the literature. Generalization of IgE dosages makes it more commonly diagnosed, though sometimes diagnosis may not be accurate.
  
  
  BACKGROUND
  The clinical picture is dominated by recurring cutaneous and visceral bacterial infections, particularly infections due to staphylococci, and severe generalized eczema, which may be associated with osteoporosis. Biochemistry includes a high level of total and specific IgE and immunological abnormalities dominated by frequent absence of immune antibodies to staphylococci and disorders of neutrophil chemotaxis. Current pathogenic studies show dysregulation of TH1 and TH2 lymphocytes in favor of TH2 activation with depressed TH1 activation, leading to an imbalance in cytokine synthesis.
  
  
  CONCLUSIONS
  New therapeutical possibilities with alpha and gamma interferon.
authors.affiliation: Service de médecine interne, immunologie clinique et allergologie, hôpital Central, Nancy, France.
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
authors.forename: G
authors.initials: G
authors.lastname: Kanny
authors.forename: G
authors.initials: G
authors.lastname: Thinus
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D016898:Interferon-alpha / Q000627:therapeutic use; D007371:Interferon-gamma / Q000627:therapeutic use; D007589:Job Syndrome / Q000175:diagnosis / Q000628:therapy
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D007371:Interferon-gamma