title: New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity.
abstract: The synthesis and the antimicrobial properties of a new series of cephalosporinic beta-lactam antibiotics is described. The data reported in the present paper show the potential of this type of substituted cephalosporins as new anti Gram-positive antibiotic drugs. In fact, all compounds tested showed a good in vitro antibacterial activity against the most relevant Gram-positive pathogens including resistant species that currently represent unmet medical need. On the contrary, the new synthesized compounds were found to be completely devoid of any activity on Gram-negative bacteria up to a concentration of the single agent of 128 microg/ml.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Balsamo
authors.forename: S
authors.initials: S
authors.lastname: Barontini
authors.forename: F
authors.initials: F
authors.lastname: Calvani
authors.forename: D
authors.initials: D
authors.lastname: Gentili
authors.forename: M
authors.initials: M
authors.lastname: Macchia
authors.forename: A
authors.initials: A
authors.lastname: Rossello
authors.forename: E
authors.initials: E
authors.lastname: Di Modugno
authors.forename: A
authors.initials: A
authors.lastname: Felici
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C030735:7-aminocephalosporanic acid