[Antral biopsy is sufficient to confirm Helicobacter pylori eradication with the "new" one-week long triple treatments].
BACKGROUND
To evaluate whether antral biopsies are enough for confirming Helicobacter pylori eradication with the "new" one week triple therapies with omeprazole.


METHODS
229 duodenal ulcer patients were treated with omeprazole for 7 days plus two antibiotics. Eradication was confirmed with histology (two biopsies from both gastric antrum and body) and 13C-urea breath test one month after the end of therapy.


RESULTS
H. pylori eradication was achieved in 76.9% of the patients (95% CI: 71-82%). Histology at antrum was highly reliable to detect eradication failure: in all but in one case in which H. pylori was observed at gastric body, was the microogranism also observed at antrum. Infection prevalences at both locations were not homogeneous (McNemar: 6.4; p < 0.05). Concordance between antral biopsies and breath test for H. pylori diagnosis after therapy was excellent (kappa: 0.91; SE: 0.07), and both prevalences were homogeneous (McNemar: 1.3; p > 0.05).


CONCLUSIONS
Taking antral biopsies is enough for confirming H. pylori eradication with the "new" one week triple therapies.
Gisbert
J P
JP
Hospital Ramón y Cajal, Departamento de Medicina, Universidad de Alcalá de Henares, Madrid. gisbert@meditex.es
Boixeda
D
D
Martín de Argila
C
C
García Plaza
A
A
D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001706:Biopsy; D017291:Clarithromycin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D009853:Omeprazole / Q000627:therapeutic use*; D010406:Penicillins / Q000008:administration & dosage; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000382:microbiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000382:microbiology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole