title: Pituitary involvement by Wegener's granulomatosis: a report of two cases.
abstract: We describe two cases of pituitary involvement by Wegener's granulomatosis. At initial presentation, or during subsequent disease "flares," a pattern of pituitary abnormality was suggested. During periods of remission, we found the pituitary returned to a nearly normal appearance. Loss of the normal posterior pituitary T1 hyper-intensity matched a clinical persistence of diabetes insipidus, suggesting there is permanent damage to this structure by the initial disease process.
authors.affiliation: Department of Radiology, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Katzman
authors.forename: C A
authors.initials: CA
authors.lastname: Langford
authors.forename: M C
authors.initials: MC
authors.lastname: Sneller
authors.forename: M
authors.initials: M
authors.lastname: Koby
authors.forename: N J
authors.initials: NJ
authors.lastname: Patronas
mesh_terms: D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000473:pathology; D018450:Disease Progression; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D010900:Pituitary Diseases / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D010904:Pituitary Gland, Posterior / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate