title: Scintigraphic diagnosis of insulinoma in a dog.
abstract: Diagnosis of insulin-secreting tumors of the pancreas can usually be made on the basis of endocrine testing and exclusion of other causes of hyperinsulinism. In dogs, these tumors have a poor long-term prognosis due to a high rate of metastases and recurrence; staging (and therefore prognosticating) is difficult and usually done at the time of surgery. The purpose of this article is to describe a canine patient with an insulinoma, discuss the diagnostic imaging options for tumor evaluation and mention future directions for therapy. Insulinoma was suspected in an 8-year-old intact male Irish Setter. Somatostatin receptor scintigraphy using indium In-111 pentetreotide was performed and an area of increased radiopharmaceutical accumulation was found craniomedial to the right kidney. At surgery a small mass lesion in the pancreas and a larger, closely associated mass involving a mesenteric lymph node were removed. Histopathology confirmed the diagnosis of insulinoma with regional lymph node metastasis. The dog recovered from surgery and remained normal fourteen months later.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: N V
authors.initials: NV
authors.lastname: Lester
authors.forename: S M
authors.initials: SM
authors.lastname: Newell
authors.forename: R C
authors.initials: RC
authors.lastname: Hill
authors.forename: O I
authors.initials: OI
authors.lastname: Lanz
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D007340:Insulinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D011877:Radionuclide Imaging