title: A prospective, randomized study of cardiopulmonary bypass temperature and blood transfusion.
abstract: BACKGROUND
  We hypothesized that normothermic cardiopulmonary bypass (CPB) would be associated with decreased blood loss and allogeneic transfusion requirements relative to hypothermic CPB.
  
  
  METHODS
  After obtaining institutional review board approval and informed patient consent, we conducted a prospective, randomized study of 79 patients undergoing CPB for a primary cardiac operation at normothermic (37 degrees C) (n = 44) or hypothermic temperature (25 degrees C) (n = 35). Blood loss and transfusion requirements in the operating room and for the first 24 hours in the intensive care unit were determined. A paired t test and rank sum tests were used. A p value of less than 0.05 was considered significant.
  
  
  RESULTS
  The normothermic and hypothermic CPB groups did not differ in demographic variables, CPB or cross-clamp duration, heparin sodium or protamine sulfate dose, prothrombin time, or thromboelastogram results. There were no differences between the two CPB groups in blood loss or transfusion requirements.
  
  
  CONCLUSIONS
  We found that when there was no difference in duration of CPB, normothermic and hypothermic CPB groups demonstrated similar blood loss and transfusion requirements even though other studies have shown hypothermia induces platelet dysfunction and alters the activity of the coagulation cascade.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota 55905, USA. stensrud.paul@mayo.edu
authors.forename: P E
authors.initials: PE
authors.lastname: Stensrud
authors.forename: G A
authors.initials: GA
authors.lastname: Nuttall
authors.forename: M A
authors.initials: MA
authors.lastname: de Castro
authors.forename: M D
authors.initials: MD
authors.lastname: Abel
authors.forename: M H
authors.initials: MH
authors.lastname: Ereth
authors.forename: W C
authors.initials: WC
authors.lastname: Oliver
authors.forename: S C
authors.initials: SC
authors.lastname: Bryant
authors.forename: H V
authors.initials: HV
authors.lastname: Schaff
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D016063:Blood Loss, Surgical; D001803:Blood Transfusion; D001831:Body Temperature; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013696:Temperature