title: [1H-MR spectroscopy in anorexia nervosa: the characteristic differences between patients and healthy subjects].
abstract: OBJECTIVE
  The neurophysiological and neuromorphological changes in patients with anorexia nervosa (AN) are well-known but the reason of both is still unknown. We have evaluated the usefulness of hydrogen (H1) magnetic resonance spectroscopy in anorexia nervosa.
  
  
  METHODS
  We investigated 15 patients with clinically diagnosed AN (ICD F50.0) and 17 controls without eating disorders. The body mass index (BMI) was 15.8 and 21, respectively. The spectroscopy was recorded on two voxels in the parieto-occipital white matter or in the thalamus with a water-suppressed STEAM-sequence. The metabolites were recorded with respect to phosphocreatine (PCr).
  
  
  RESULTS
  The ratio of NAA/PCr in both voxels were not significantly different when comparing patients vs. controls. Patients showed significantly higher ratios of choline-containing components (Cho) or, respectively Cho/PCr and NAA/PCr in the white matter. Distinct, but not significant differences were detected both for m-Ino and m-Ino/PCr in the parieto-occipital region and for the Cho- and m-Ino contained ratios in the thalamus.
  
  
  CONCLUSIONS
  AN is not associated with neuronal damage. The ratio of Cho/PCr and NAA/Cho may reflect the disturbance of membrane-turnover. It is possible that the increase of membrane catabolism leads to a hyperosmolar state. The change of m-Ino/PCr ratio may reflect the regulation of osmolarity.
authors.affiliation: Abteilung für Neuroradiologie ZI Mannheim, Fakultät für klinische Medizin Mannheim, Universität Heidelberg. Hentsche@as200.zi-mannheim.de
authors.forename: J
authors.initials: J
authors.lastname: Hentschel
authors.forename: R
authors.initials: R
authors.lastname: Möckel
authors.forename: H P
authors.initials: HP
authors.lastname: Schlemmer
authors.forename: A
authors.initials: A
authors.lastname: Markus
authors.forename: C
authors.initials: C
authors.lastname: Göpel
authors.forename: F
authors.initials: F
authors.lastname: Gückel
authors.forename: J
authors.initials: J
authors.lastname: Köpke
authors.forename: M
authors.initials: M
authors.lastname: Georgi
authors.forename: M H
authors.initials: MH
authors.lastname: Schmidt
mesh_terms: D000856:Anorexia Nervosa / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D015992:Body Mass Index; D002794:Choline / Q000378:metabolism; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D009778:Occipital Lobe / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism*
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D002794:Choline