Antitumor drug delivery by tissue electroporation.
Tissue electroporation has been explored to enhance the local delivery of chemotherapueutic agents to solid tumors. The technique, known as electrochemotherapy (ECT), uses high-voltage pulses to deliver drugs across cancerous tissues. ECT has been demonstrated to be an effective treatment for cutaneous malignancies. Recent studies also indicate that the applications of ECT can be extended from the treatment of cutaneous cancers to the treatment of tumors of vital organs such as brain, liver, lungs and others. This review also discusses electrogene antitumor therapy.
Singh
B N
BN
Department of Industrial Pharmacy, College of Allied Health Professions, Saint Johns University, Jamaica, NY 11429, USA.
Dwivedi
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002462:Cell Membrane; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D018274:Electroporation / Q000379:methods*; D005544:Forecasting; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents