Immune activation in non-treated suicidal major depression.
In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is associated with most of autoimmune diseases. It is thus speculated that Th1 activation in suicidal depression may reflect a unique form of autoimmune suicide.
Mendlovic
S
S
Shalvata Mental Health Center, Hod-Hasharon, Israel. mendlov@netvision.net.il
Mozes
E
E
Eilat
E
E
Doron
A
A
Lereya
J
J
Zakuth
V
V
Spirer
Z
Z
D016207:Cytokines / Q000378:metabolism*; D003863:Depression / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013405:Suicide; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines