title: Basic clinical study of an easy and effective leukocytapheresis by the use of nonwoven polyester filter.
abstract: Leukocytapheresis (LCAP) is widely used for the treatment of immunological diseases. We studied a new treatment of LCAP using a nonwoven polyester filter. In a basic study, 30-70% of the lymphocytes were adsorbed. Also, 30-68% of the lymphocyte subsets were removed. This method was applied to 2 patients with corticosteroid-resistant active ulcerative colitis. Erosion, edema, bleeding, ulcer formation, and stenosis of the colon were almost completely repaired after 6 LCAP treatments. LCAP using a nonwoven polyester filter will be a very useful treatment for immunological diseases and extracorporeal immunomodulation.
authors.affiliation: Department of Surgery, Sapporo Hokuyu Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Osanai
authors.forename: M
authors.initials: M
authors.lastname: Katori
authors.forename: M
authors.initials: M
authors.lastname: Yonekawa
authors.forename: M
authors.initials: M
authors.lastname: Saitoh
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000628:therapy; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation*; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D008297:Male; D011091:Polyesters; D016896:Treatment Outcome; D014462:Ultrafiltration / Q000295:instrumentation
chemical_list: D011091:Polyesters