title: Atrioventricular nodal conduction during atrial fibrillation: role of atrial input modification.
abstract: BACKGROUND
  Posteroseptal ablation of the atrioventricular node (AVN) has been proposed as a means to slow the ventricular rate during atrial fibrillation (AF). The suggested mechanism is elimination of the AVN "slow pathway." On the basis of the unpredictable success of the procedure, we hypothesize that, in fact, the slow pathway is preserved. Therefore, the slowing of the ventricular rate results from reduced bombardment of the AVN.
  
  
  RESULTS
  In 8 rabbit heart atrial-AVN preparations, cooling of the posterior and/or the anterior AVN approaches revealed nonspecific effects on the slow and fast pathway portions of the AVN conduction curve. In 13 other preparations, simulated AF during posterior cooling (n=6) prolonged the His-His (H-H) intervals but did not reveal specific slow pathway injury. In the remaining 7 preparations, AF was applied before and after posteroseptal surgical cuts. During AF with posterior origin, the cuts resulted in longer mean H-H along with slowing of the AVN bombardment rate. However, there was no change in the minimum observed H-H, suggesting an intact slow pathway. During AF with anterior origin, the mean and the shortest H-H remained unchanged before and after the cuts in all preparations. This was associated with the maintenance of high-rate AVN bombardment.
  
  
  CONCLUSIONS
  Posteroseptal ablation does not eliminate the slow pathway. Ventricular rate slowing can be obtained if the ablation procedure results in a posteroanterior intra-atrial block leading to a reduction of the rate of AV nodal bombardment.
authors.affiliation: Department of Cardiology, the Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: S
authors.initials: S
authors.lastname: Garrigue
authors.forename: K A
authors.initials: KA
authors.lastname: Mowrey
authors.forename: G
authors.initials: G
authors.lastname: Fahy
authors.forename: P J
authors.initials: PJ
authors.lastname: Tchou
authors.forename: T N
authors.initials: TN
authors.lastname: Mazgalev
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000503:physiopathology*; D001283:Atrioventricular Node / Q000503:physiopathology*; D005260:Female; D008297:Male; D011817:Rabbits; D015203:Reproducibility of Results