title: Severe anaphylactic reaction after primary exposure to aprotinin.
abstract: Aprotinin is widely used to prevent bleeding and reduce blood transfusions after open heart surgical procedures. Because it is a foreign protein, aprotinin has allergenic potential. We report a case of near-fatal anaphylactic reaction to primary aprotinin exposure in a child successfully treated using cardiopulmonary bypass support. The possibility of an allergic reaction must be considered whenever this drug is used.
authors.affiliation: Department of Anesthesiology, Ohio State University College of Medicine and Children's Hospital, Columbus 43205, USA. cohend@chi.osu.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Cohen
authors.forename: J
authors.initials: J
authors.lastname: Norberto
authors.forename: R
authors.initials: R
authors.lastname: Cartabuke
authors.forename: G
authors.initials: G
authors.lastname: Ryu
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced* / Q000628:therapy; D007611:Aprotinin / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D005260:Female; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans
chemical_list: D006490:Hemostatics; D007611:Aprotinin