title: The effects of Ehrlichia (Cytoecetes) phagocytophila on the clinical chemistry of sheep and goats.
abstract: Tick-borne fever (TBF) is a rickettsial disease of domestic and wild ruminants in temperate climates where the hard tick Ixodes ricinus is present. The disease is characterized by a high temperature and severe leukopenia. In the present study, the effects of TBF on the activity of serum alkaline phosphatase (ALP), and on the concentrations of plasma zinc, iron, total bilirubin, urea, creatinine and albumin were investigated by inoculating one group of eight sheep and one group of eight goats with the Old Sourhope (OS) strain of Ehrlichia (Cytoecetes) phagocytophila. All goats and sheep experimentally infected with E. phagocytophila reacted with fever, rickettsiaemia and leukopenia. The leukopenia was due to an acute lymphocytopenia and prolonged neutropenia. In both groups of animals. TBF was characterized by significant reductions in the activities of serum ALP and concentrations of plasma zinc, iron and albumin. However, there were significant increases in the concentrations of plasma total bilirubin, urea and creatinine in both species of animals. The reductions in ALP and iron were significantly more pronounced in sheep than in goats.
authors.affiliation: Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, UK.
authors.forename: H I
authors.initials: HI
authors.lastname: Gokce
authors.forename: Z
authors.initials: Z
authors.lastname: Woldehiwet
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D003404:Creatinine / Q000097:blood; D016873:Ehrlichiosis / Q000097:blood / Q000662:veterinary*; D015511:Goat Diseases / Q000097:blood*; D006041:Goats; D007501:Iron / Q000097:blood; D012709:Serum Albumin / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood*; D013997:Time Factors; D014508:Urea / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D012709:Serum Albumin; D014508:Urea; D003404:Creatinine; D007501:Iron; D000469:Alkaline Phosphatase; D015032:Zinc; D001663:Bilirubin