Non-Hodgkin's lymphoma of the maxillary sinus in a patient with acquired immunodeficiency syndrome.
Non-Hodgkin's lymphoma (NHL) is one of the most common malignancies in patients infected with human immunodeficiency virus (HIV): it occurs 25-60 times more frequently in HIV-infected patients than in the general population. This neoplasm in acquired immunodeficiency syndrome (AIDS) patients is a highly aggressive tumour with a poor prognosis and tends to develop in extranodal sites, such as the central nervous system, digestive tract and bone marrow. NHL involving the paranasal sinuses is rare in HIV-infected patients, and is likely to be confused clinically and radiographically with sinusitis; moreover, its optimal treatment is currently uncertain. We present a case of NHL involving the left maxillary sinus in a patient with AIDS. The patient was treated with systemic chemotherapy (low dose-CHOP), but the malignancy did not respond. Subsequently, he was treated with local maxillary sinus irradiation which resulted in partial regression of the neoplasm and in decrease of local symptoms.
Del Forno
A
A
Department of Infectious Diseases, Catholic University, Rome, Italy.
Del Borgo
C
C
Turriziani
A
A
Ottaviani
F
F
Antinori
A
A
Fantoni
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000000981:diagnostic imaging / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000628:therapy; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone