Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
Ornithine decarboxylase (ODC) transgenic and alpha-difluoromethyl ornithine (DFMO)-treated rats were exposed to transient middle cerebral occlusion (MCAO) to examine the role of intraischaemic ODC-activity on the evolution of ischaemia-reperfusion damage. Magnetic resonance imaging (MRI) data show that the damage develops slower in ODC transgenic than in DFMO-treated rats, which is not caused by a difference in perfusion. Furthermore, infarct volumes are smaller in the former animals one day later. These data support the idea of endogenous neuroprotective action of ODC.
Lukkarinen
J A
JA
NMR Research Group, A.I. Virtanen Institute for Molecular Sciences, University of Kuopio, Kuopio, Finland.
Gröhn
O H
OH
Alhonen
L I
LI
Jänne
J
J
Kauppinen
R A
RA
D000818:Animals; D030801:Animals, Genetically Modified; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000201:enzymology; D001923:Brain Chemistry / Q000235:genetics; D002545:Brain Ischemia / Q000175:diagnosis / Q000201:enzymology*; D002421:Caudate Nucleus / Q000098:blood supply / Q000201:enzymology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000201:enzymology*; D002544:Cerebral Infarction / Q000175:diagnosis / Q000201:enzymology*; D018450:Disease Progression; D015971:Gene Expression Regulation, Enzymologic; D008279:Magnetic Resonance Imaging; D009955:Ornithine Decarboxylase / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D019076:Transgenes / Q000502:physiology
D009955:Ornithine Decarboxylase