title: Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS.
abstract: We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA.
authors.forename: B G
authors.initials: BG
authors.lastname: Weinshenker
authors.forename: D
authors.initials: D
authors.lastname: Hebrink
authors.forename: D M
authors.initials: DM
authors.lastname: Wingerchuk
authors.forename: C J
authors.initials: CJ
authors.lastname: Klein
authors.forename: E
authors.initials: E
authors.lastname: Atkinson
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: C T
authors.initials: CT
authors.lastname: McMurray
mesh_terms: D002874:Chromosome Mapping; D014644:Genetic Variation; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D009154:Mutation; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*
chemical_list: D018124:Receptors, Tumor Necrosis Factor