title: Quantitative abdominal aortic flow measurements at controlled levels of ergometer exercise.
abstract: Measuring the exercise-induced flow changes in the arteries of the body is a major challenge. The use of quantitative MR flow measurements for this purpose is hampered by movement artifacts and ECG triggering problems. To quantify exercise-induced flow changes in the abdominal aorta, we applied a fast hybrid phase contrast sequence with K-space segmentation and echo planar imaging readouts during a 12 heart beat, single breathhold post exercise scanning window after ergometer exercise in nine volunteers. Central k-space was acquired first. The changes in heart rate throughout the scanning window were quantified. The mean decrease in heart rate after six heart beats post exercise was less than 4% and less than 14% after 11 heart beats indicating that the exercise state was very well represented during the acquisition of central k-space. Abdominal aortic flow increased from 1.4+/-0.3 l/min at rest to 7.9+/-1.1 l/min at 131 watt. Retrograde flow reached a maximum value of 1.2 l/min at rest, and lasted 140 ms on average. Only for one out of the nine volunteers was there any retrograde flow present during exercise (at 33 watt and 65 watt exercise). It was concluded that retrograde flow patterns in the abdominal aorta associated with oscillating wall shear stresses and development of atherosclerosis disappeared with increasing levels of exercise. The feasibility of using fast quantitative phase contrast measurements during a post exercise scanning window to represent controlled exercise levels was demonstrated.
authors.affiliation: Dept. Cardiothoracic and Vascular Surgery T, MR-Center, Institute of Experimental Clinical Research, Aarhus University Hospital, Skejby Sygehus, Denmark. skejemp@aau.dk
authors.forename: E M
authors.initials: EM
authors.lastname: Pedersen
authors.forename: S
authors.initials: S
authors.lastname: Kozerke
authors.forename: S
authors.initials: S
authors.lastname: Ringgaard
authors.forename: M B
authors.initials: MB
authors.lastname: Scheidegger
authors.forename: P
authors.initials: P
authors.lastname: Boesiger
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal / Q000033:anatomy & histology / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D017352:Echo-Planar Imaging / Q000379:methods*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male