Beneficial effect of combination antiplatelet therapy on the development of experimental Staphylococcus aureus endocarditis.
Previous studies in our laboratory have shown that antiplatelet agents, aspirin and ticlopidine, in clinically relevant concentrations influence the development and treatment of experimental endocarditis. To study the influence of combination antiplatelet treatment on the development of aortic vegetations, infected animals received either aspirin alone, ticlopidine alone, aspirin plus ticlopidine or no antiplatelet therapy. The combination antiplatelet treated group had a statistically significant (P = 0.043) reduction of the vegetative weight as compared with the untreated controls. While both the single antiplatelet agent groups showed a reduction in the size of the vegetation, neither achieved statistical significance. None of the treatment groups significantly altered the bacterial density relative to untreated controls. These findings reveal that the combination of aspirin and ticlopidine, two potent inhibitors of platelet aggregation with different mechanisms of action, act synergistically to optimally reduce the weight of aortic valve vegetations.
Nicolau
D P
DP
Department of Pharmacy Research, Hartford Hospital, CT 06102, USA. dnicola@harthosp.org
Tessier
P R
PR
Nightingale
C H
CH
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013988:Ticlopidine / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; D001241:Aspirin