In vitro and in vivo experimental activities of antifungal agents against Fusarium solani.
In the treatment of disseminated Fusarium infections, amphotericin B either alone or in combination with flucytosine and rifampin is the drug therapy most frequently used. The efficacy of these antifungal drugs was evaluated in a murine disseminated-infection model, with five strains of Fusarium solani. All the treatments were clearly ineffective.
Guarro
J
J
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, 43201 Reus, Tarragona, Spain.
Pujol
I
I
Mayayo
E
E
D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000904:Antibiotics, Antitubercular / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000494:pharmacology / Q000627:therapeutic use; D005670:Fusarium / Q000187:drug effects*; D008297:Male; D051379:Mice; D009181:Mycoses / Q000188:drug therapy*; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use
D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine; D012293:Rifampin