[Study on the dose-effect relationship of hypolipidemic effect of deepsea fish oil].
The dose-effect relationship of hypolipidemic effect of fish oil was studied. The rats were divided into four groups: 2.5, 5, 10 g/kg and high dietary fat control group. The experimental rat model of high serum lipids was developed. The results showed that there was a linear correlation between the levels of TG, HDL-c and the dosage of fish oil. Fish oil reduced TC level and elevated HDL-c level steadily. But no linear correlation was observed between TC, LDL-c and the dosage of fish oil. The level of TC and LDL-c decreased markedly at the dosage of 2.5 g/kg of fish oil.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D009792:Oceans and Seas; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood