Effects of dopexamine on blood flow in multiple splanchnic sites measured by laser Doppler velocimetry in rabbits undergoing cardiopulmonary bypass.
Decreased gut perfusion has been reported during cardiopulmonary bypass (CPB). Studies of treatments to avoid splanchnic ischaemia during CPB have given conflicting results. We studied 12 rabbits during mild hypothermic non-pulsatile CPB. Tissue blood flow in three different splanchnic areas (gastric, jejunum and ileum) was measured by laser Doppler velocimetry (LDV) before CPB (T0), after steady state (T1), after administration of dopexamine 2 micrograms kg-1 min-1 (T2) and 4 micrograms kg-1 min-1 (T3), and after return to baseline (T4). Splanchnic blood flow decreased during CPB. Dopexamine increased significantly jejunum LDV (100% at T1 to mean 271 (SD 210)% at T2) and ileum LDV (100% at T1 to 187 (112)% at T2). Gastric LDV was not altered by infusion of dopexamine during CPB. This could partly explain the conflicting results on the value of gastric tonometry as an index of splanchnic injury.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002315:Cardiopulmonary Bypass; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007082:Ileum / Q000098:blood supply; D007583:Jejunum / Q000098:blood supply; D017078:Laser-Doppler Flowmetry; D008297:Male; D011817:Rabbits; D013152:Splanchnic Circulation / Q000187:drug effects*; D013270:Stomach / Q000098:blood supply; D014665:Vasodilator Agents / Q000494:pharmacology*