title: Morphological, morphometric, and functional differences in the vestibular organ of different breeds of the rat (Rattus norvegicus).
abstract: In the laboratory rat, differences in shape, dimension and function of the cochlea have been reported for various breeds. In contrast, no comparable investigations to date have been undertaken for the vestibular organ in different breeds of the rat. Vestibular organs of two breeds of rat (Wistar, Sprague-Dawley) were analyzed morphologically and morphometrically by means of microdissection techniques in order to determine the mechanical sensitivity of the cupula according to Oman et al; (Acta Otolaryngol., 1987;103:1-13, 1987). Differences in shape of the lateral semicircular duct exist between the two breeds and the cupular mechanical sensitivity is significantly higher in Wistar than in Sprague-Dawley rats. With respect to the other semicircular ducts, no differences in shape were found between the two strains. The cupular mechanical sensitivity of the anterior semicircular duct, however, is higher in Wistar than in Sprague-Dawley rats. The breeds also differ in the shape of their utriculus; obviously a correlation exists between the latter and the cupular mechanical sensitivity of the semicircular ducts. There are differences in the vestibular organs between the two breeds of the laboratory rat investigated. The cupular mechanical sensitivity of the semicircular duct does not seem to be correlated to body mass. The size and morphology of the utriculus influence the mechanical sensitivity of a single duct, but differences only become significant if other parameters also differ.
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012444:Saccule and Utricle / Q000033:anatomy & histology / Q000502:physiology; D012665:Semicircular Canals / Q000033:anatomy & histology / Q000502:physiology; D013045:Species Specificity; D014722:Vestibule, Labyrinth / Q000033:anatomy & histology* / Q000502:physiology*