Cytogenetic analysis of a mature teratoma and a yolk sac tumor component of a late relapse of a disseminated testicular nonseminoma.
We report on the cytogenetics of a primary testicular nonseminoma, a residual mature teratoma after remission-induction chemotherapy, and a late relapse after 9 years of follow-up, in one patient. The late relapse was composed of a mature teratoma and a yolk sac tumor component. Cytogenetic comparison of the different tumors shows that progression of primary testicular nonseminoma to residual mature teratoma and to a late-relapse lesion is accompanied by net loss of chromosomes. In addition, our findings may suggest that transformation to viable cancer in a late-relapse lesion is accompanied by further chromosomal losses.
D000328:Adult; D018240:Endodermal Sinus Tumor / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008677:Metaphase / Q000235:genetics; D012008:Recurrence; D013724:Teratoma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology