Novel genes for familial combined hyperlipidemia.
Familial combined hyperlipidemia (FCHL) is a complex genetic disorder of unknown etiology. Recently, 'modifier' genes of the FCHL phenotype, such as the apolipoprotein AI-CIII-AIV gene cluster and LPL, have been identified in several populations. A 'major' gene for FCHL has been identified in a Finnish isolate which maps to a region syntenic to murine chromosome 3 where a locus for combined hyperlipidemia has been identified. We review these and other recent studies which indicate that FCHL is genetically heterogeneous.
D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D005387:Finland; D008040:Genetic Linkage; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D010641:Phenotype