A qualitative estimate of the influence of halcinonide concentration and urea on the reservoir formation in the stratum corneum.
The existence of a stratum corneum reservoir for topically applied substances is well known. Data concerning the stratum corneum retention time are important for the elaboration of optimal topical treatment. We used the re-occlusion technique followed by skin colour measurements (Chromametry) for the evaluation of the stratum corneum retention time of halcinonide. We found a significant reservoir for halcinonide up to 5 days after the initial application. The retention was found to be corticosteroid concentration and formulation dependent.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003124:Colorimetry / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004817:Epidermis / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids; D006206:Halcinonide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013997:Time Factors; D014508:Urea / Q000494:pharmacology*