T-cell development: a role for self-peptides in positive selection.
An important issue for immunologists is the difference between the two main processes that determine the mature repertoire of T-cell receptors, termed positive and negative selection. Recent papers have addressed the role of self-peptides in the process of positive selection.
D000818:Animals; D002454:Cell Differentiation; D010455:Peptides / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*