[The correlation between abusing alcohol and antioxidants, antioxidases].
OBJECTIVE
To study the correlation between abusing alcohol and antioxidants, antioxidases and oxygen free radical reaction.


METHODS
We measured spectrophotometrically the plasma vitamin C(P-VC), plasma vitamin E(P-VE), plasma beta-carotene (P-beta-CAR) contents and erythrocyte superoxide dismutase (E-SOD), erythrocyte catalase (E-CAT), erythrocyte glutathione peroxidase (E-GSH-Px) activities in 194 male (40 years old) alcohol abusers and 50 male (40 years old) nondrinkers.


RESULTS
The average P-VC, P-VE, P-beta-CAR contents and E-SOD, E-CAT, E-GSH-Px activities of the alcohol abuser group were lower than those of the nondrinker group. The P-VC, P-VE, P-beta-CAR contents and E-SOD, E-CAT, E-GSH-Px activities of the alcohol abusers decreased as the time and quantity of abusing alcohol increased.


CONCLUSIONS
The oxygen free radical reaction in the alcohol abusers was pathologically exacerbated, and the balance between oxidation and antioxidation was serious imbalanced.
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000201:enzymology*; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D002374:Catalase / Q000097:blood; D016166:Free Radical Scavengers / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood*; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood