[Experimental study on effect of zhuyu tongfu mixture on anti-enterogenous infection caused by endotoxin].
OBJECTIVE
To evaluate the effect of Zhuyu Tongfu mixture (ZYTFM) in curing enterogenus infection.


METHODS
Experimental model of enterogenous infection in mice caused by endotoxin was used. The positive translocation trate (PTR) and mumber of viable bacteria in viscera and serum level of superoxide dismutase (SOD) were measured before and after ZYTFM treatment.


RESULTS
The PTR and number of viable bacteria in liver, spleen and mesocolon in the ZYTFM group were much lower than those in the model group and the placebo group (P < 0.01). Whereas the SOD level of the ZYTFM group was significantly higher than that in the latter two groups (P < 0.05-0.01). Pathological examination displayed that ZYTFM could markedly alleviate the mucosal damage of small intestine.


CONCLUSIONS
ZYTFM has an obvious curative effect on enterogenous infections induced by endotoxin.
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D019446:Endotoxemia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D004731:Endotoxins; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008297:Male; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism*