In utero treatment of fetal complete heart block with terbutaline. A case report.
BACKGROUND
Isolated fetal complete heart block is an uncommon finding, with a mortality rate of 20-30%. Various treatment modalities have been reported, with no consistent success.


METHODS
Fetal complete heart bock was diagnosed in a 30-year-old woman at 29 weeks' gestation. She had an elevated antinuclear antibody and anti-SSA antibody titer. Fetal cardiac decompensation was detected at 32 weeks. After a trial of intravenous isoproterenol without significant side effects, she was treated with oral terbutaline. An increase in the fetal ventricular rate and complete resolution of hydrops fetalis occurred. A male infant was delivered by cesarean section, at term, and underwent cardiac pacemaker implantation at 4 days of age.


CONCLUSIONS
The treatment of fetal complete heart block is controversial. Premature delivery with cardiac pacing is associated with high morbidity and mortality. We report prenatal treatment with oral sympathomimetic medication, which allowed delivery to be delayed until term, with a successful outcome.
D000284:Administration, Oral; D000328:Adult; D002304:Cardiac Pacing, Artificial; D002585:Cesarean Section; D016640:Diabetes, Gestational / Q000150:complications; D004562:Electrocardiography; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000188:drug therapy*; D006327:Heart Block / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology; D007231:Infant, Newborn; D007545:Isoproterenol / Q000627:therapeutic use; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D013566:Sympathomimetics / Q000627:therapeutic use*; D013726:Terbutaline / Q000627:therapeutic use*