DNA chips: promising toys have become powerful tools.
DNA chips are glass surfaces that represent thousands of DNA fragments arrayed at discrete sites. Hybridization of RNA or DNA-derived samples to DNA chips allows us to monitor expression of mRNAs or the occurrence of polymorphisms in genomic DNA. The technology holds great promise for identifying gene polymorphisms that predispose man to disease, gene regulation events involved in disease progression, and more-effective disease treatments.
D004252:DNA Mutational Analysis / Q000379:methods; D016208:Databases, Factual; D005544:Forecasting; D015870:Gene Expression; D008040:Genetic Linkage; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010600:Pharmacology / Q000379:methods; D011110:Polymorphism, Genetic; D012680:Sensitivity and Specificity