[Clinical and experimental studies of supplemented sini san in treating chronic brucellosis].
OBJECTIVE
To observe the effect of supplemented Sini San (SSNS) in treating chronic Brucellosis (CB).


METHODS
One hundred and twenty-seven patients were randomly divided into two groups, 76 cases in the treatment group were treated with SSNS and 51 cases in the control group treated with Dioscorea Nipponica Power. The effect of SSNS on mice model of CB was also observed simultaneously.


RESULTS
The short-term effects were that the total effective rate and markedly effective rate of the treatment were 98.7% and 92.1%, which were better than those of the control group (82.4% and 41.2%) respectively, P < 0.01. The long-term follow-up result of the treatment group also showed its superiority to the control group, the total effective rates of the two groups were 98.7% and 51.0%, and the markedly effective rates were 90.8% and 21.6% respectively (P < 0.01). Animal experiments indicated SSNS has obvious effect of antibiotics and immunomodulation.


CONCLUSIONS
SSNS was effective in treating CB, including the long-term follow-up result.
D000328:Adult; D000368:Aged; D000818:Animals; D000917:Antibody Formation; D002006:Brucellosis / Q000188:drug therapy* / Q000276:immunology; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged