A novel Campylobacter jejuni two-component regulatory system important for temperature-dependent growth and colonization.
Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS (reduced ability to colonize) system, that is involved in a temperature-dependent signalling pathway. A mutation of the response regulator gene racR reduced the organism's ability to colonize the chicken intestinal tract and resulted in temperature-dependent changes in its protein profile and growth characteristics.
D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D016123:Campylobacter jejuni / Q000166:cytology / Q000201:enzymology / Q000235:genetics / Q000254:growth & development*; D002455:Cell Division; D002645:Chickens / Q000382:microbiology; D003001:Cloning, Molecular; D015169:Colony Count, Microbial; D004064:Digestive System / Q000382:microbiology; D015180:Electrophoresis, Gel, Two-Dimensional; D015964:Gene Expression Regulation, Bacterial; D000071677:Histidine Kinase; D007526:Isoelectric Point; D008969:Molecular Sequence Data; D008970:Molecular Weight; D016254:Mutagenesis, Insertional; D016366:Open Reading Frames / Q000235:genetics; D009876:Operon / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D018085:Regulon / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D013696:Temperature; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology