title: Pronounced palatal and mandibular tori observed in a patient with chronic phenytoin therapy: a case report.
abstract: Phenytoin, an anticonvulsant drug for epileptic patients, has many adverse effects, including calvarial thickening and coarsening of the facial features. Previous studies have demonstrated that phenytoin has an anabolic action on bone cells. This report describes pronounced palatal and mandibular tori found in a 45-year-old Japanese man undergoing chronic phenytoin therapy. The tori were extremely large, lobular, and symmetrical. A palatal torus appeared along the middle of the hard palate and mandibular tori consisted of 2 pairs of nodular masses extensively filling the lingual floor of the oral cavity. Pronounced osseous outgrowth occurred for the duration of a dose-increase of phenytoin from 1985 to 1997. His parents did not have any palatal or mandibular tori. These facts suggest that these unusual tori may have been the result of chronic phenytoin therapy, rather than association with the familial background.
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D005096:Exostoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged; D010159:Palate / Q000187:drug effects* / Q000473:pathology; D010672:Phenytoin / Q000009:adverse effects*