The effect of anthocyanosides on night vision.
OBJECTIVE
In view of research demonstrating the ability of anthocyanosides in a single oral dose to improve night vision in normal individuals, it was decided to evaluate their effect on three night vision tests: full-field scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS).


METHODS
In a double-masked, placebo-controlled, cross-over study, 16 young normal volunteers were randomly assigned to one of four different regimens of single oral administrations of 12, 24 and 36 mg of anthocyanosides, and a placebo, with a 2 week washout period between doses. SRT, DAR and MCS were measured immediately before, and 4, 8 and 24 h after treatment.


RESULTS
No significant effect was found on any of the three night vision tests during the 24 h following a single oral administration of 12, 24 or 36 mg anthocyanosides. The study had a power of 0.95 to detect a 0.1 log unit improvement in SRT and 0.5 log unit improvement in MCS.


CONCLUSIONS
Single oral administration of 12-36 mg of anthocyanosides appears to lack significant effect on militarily relevant night vision tests.
D000328:Adult; D000872:Anthocyanins / Q000494:pharmacology*; D015350:Contrast Sensitivity / Q000187:drug effects; D018592:Cross-Over Studies; D003623:Dark Adaptation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005638:Fruit; D006801:Humans; D008297:Male; D012684:Sensory Thresholds / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects*