Stimulation of the 5-HT1A receptor selectively suppresses NMDA receptor-mediated synaptic excitation in the rat visual cortex.
We have previously found that stimulation of serotonin 5-HT1A receptors inhibits the induction of long-term potentiation (LTP) in the rat visual cortex. In the present study, the selective 5-HT1A receptor agonist 8-hydroxy-2-(N,N-dipropylamino)tetralin (8-OH-DPAT) significantly reduced N-methyl-d-aspartate (NMDA) receptor-mediated synaptic responses recorded in Mg2+-free medium in rat visual cortical slices. In addition, there was good correlation between the inhibitory effects of 8-OH-DPAT on NMDA responses and LTP. These results suggest that 5-HT1A receptor stimulation inhibits the induction of LTP by suppressing NMDA receptor-mediated synaptic excitation in the rat visual cortex.
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013569:Synapses / Q000737:chemistry* / Q000187:drug effects; D014793:Visual Cortex / Q000737:chemistry* / Q000502:physiology