Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.
A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D002784:Cholesterol / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology*; D005227:Fatty Acids / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D008099:Liver / Q000033:anatomy & histology / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism* / Q000502:physiology*; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors