Analysis of B-cell epitopes of the Ro/SS-A autoantigen.
Autoantibodies to the Ro and La ribonucleoprotein antigens are found in several rheumatoid diseases. The important epitopes have been studied using synthetic peptides and recombinant antigens to understand how they arise and their implication in disease. Here, we analyse the results of epitope mapping studies of Ro60 and Ro52 autoantigens and focus on the major findings to date.
D000818:Animals; D001323:Autoantibodies; D001324:Autoantigens; D001402:B-Lymphocytes / Q000276:immunology*; D018604:Epitope Mapping; D006801:Humans; D020733:RNA, Small Cytoplasmic; D012216:Rheumatic Diseases / Q000276:immunology; D012261:Ribonucleoproteins; D000099207:SS-A Antigen