Hepatoprotective effect of Vitex negundo against carbon tetrachloride-induced liver damage.
Alcoholic extract of the seeds of Vitex negundo Linn. was obtained by cold maceration. A dose of 250 mg/kg (1/6 of LD50) of the extract was selected to study the hepatoprotective action against carbon tetrachloride-induced liver damage. The extract was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats