[Effect of Astragalus Angelica mixture on serum lipids and glomerulosclerosis in rats with nephrotic syndrome].
OBJECTIVE
To confirm the renal protective action of Astragalus Angelica mixture (AAM).


METHODS
Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as positive control.


RESULTS
AAM could not only reduce the serum levels of total cholesterol and triglyceride as pravachol did, but also could lower levels of low density lipoprotein and apolipoprotein B100 (P < 0.05). Light microscopic and immuno-histochemical examination revealed that in the same time of lowering serum lipids, this mixture could also cause reduction of glomerular sclerosing index (P < 0.01) and less accumulation of extracellular matrix (P < 0.01).


CONCLUSIONS
AAM has the effects of regulating lipid metabolism, attenuating renal damage and maintaining renal function in rats with nephrotic syndrome.
D000818:Animals; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005920:Glomerular Mesangium / Q000473:pathology*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D011691:Puromycin; D051381:Rats; D017207:Rats, Sprague-Dawley; D012598:Sclerosis; D014280:Triglycerides / Q000097:blood