[Somatostatin and electroacupuncture inhibited c-fos expression in spinal cord of arthritic rats].
OBJECTIVE
To observer the effect of intrathecal injection of somatostatin (Som) associated with electroacupuncture (EA) at "Jiaji" points on c-fos protein expression of spinal cord in pain rats.


METHODS
Rats with adjuvant arthritis were used as pain model and the c-fos-like immunoreactivity (FLI) was detected by immunohistochemistry.


RESULTS
The c-fos protein expression induced by arthritis were found in all of the I-X laminae of ipsilateral spinal cord of rats, and most of the labeled cells were located in the laminae I-II and V-VI. Som and EA suppressed the c-fos expression and the lessening of FLI cells in the spinal cord.


CONCLUSIONS
Pathological pain following arthritis activated pain sensitive neurons (PSN) and evoked c-fos expression in spinal cord, Som and EA suppressed activities of these PSN, producing the effect of analgesia.
D015667:Acupuncture Analgesia; D000698:Analgesia; D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism*; D015671:Electroacupuncture; D005260:Female; D007278:Injections, Spinal; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000494:pharmacology*; D013116:Spinal Cord / Q000378:metabolism*