Synthesis of cancer peptide antigen-lipid A analog conjugates for synthetic vaccines.
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine-beta-alanine-containing D-glucosamine derivative structurally related to lipid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers. The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.
D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry*; D019496:Cancer Vaccines / Q000138:chemical synthesis* / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D018796:Immunoconjugates / Q000737:chemistry* / Q000494:pharmacology*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000737:chemistry; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data