Application of a rheolytic thrombectomy device in the treatment of dural sinus thrombosis: a new technique.
We present a novel application of a transvascular rheolytic thrombectomy system in the treatment of symptomatic dural sinus thrombosis in a 54-year-old woman with somnolence and left-sided weakness. The diagnosis of bilateral transverse and superior sagittal sinus thrombosis was made and the patient was treated with anticoagulant therapy. After an initial period of improvement, she became comatose and hemiplegic 8 days after presentation. After excluding intracerebral hemorrhage by MR imaging, we performed angiography and transfemoral venous thrombolysis with a hydrodynamic thrombectomy catheter, followed by intrasinus urokinase thrombolytic therapy over the course of 2 days. This technique resulted in dramatic sinus thrombolysis and near total neurologic recovery. Six months after treatment, the patient showed mild cognitive impairment and no focal neurologic deficit. Our preliminary experience suggests that this technique may play a significant role in the endovascular treatment of this potentially devastating disease.
D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D002406:Catheterization, Peripheral / Q000295:instrumentation / Q000379:methods; D002533:Cerebral Angiography; D003072:Cognition Disorders / Q000209:etiology; D003128:Coma / Q000209:etiology; D004388:Dura Mater; D004867:Equipment Design; D005260:Female; D005263:Femoral Artery; D005500:Follow-Up Studies; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use; D012212:Rheology / Q000295:instrumentation; D012851:Sinus Thrombosis, Intracranial / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D012894:Sleep Stages / Q000502:physiology; D017131:Thrombectomy / Q000295:instrumentation* / Q000379:methods; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use