The dynamics of HTLV-I and the CTL response.
Dominik Wodarz and colleagues describe a mathematical model for the in vivo dynamics of human T-cell leukaemia virus type 1 (HTLV-I) infection and the virus-specific cytotoxic T lymphocyte response. They show that a high rate of viral replication is consistent with the relative sequence invariance of HTLV-I and might be necessary to maintain a persistent infection.
D000998:Antiviral Agents / Q000627:therapeutic use; D015490:HTLV-I Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014779:Virus Replication