[Recurrent osteitis and Coxiella burnetii: the relation to chronic recurrent multifocal osteomyelitis].
Chronic recurrent multifocal osteomyelitis (CRMO) is a disorder of suspected--but unproved-infectious etiology.


METHODS
A girl presented with a typical CRMO involving successively the left fibula, radius, humerus and the right carpus. A Coxiella burnetii infection was indicated during the first attack. Two recurrences occurred in spite of suitable antibiotic treatment and with negative infectious investigation. Two months after stopping antibiotic treatment, a new recurrence associated with antibodies increase and positive bone culture occurred.


CONCLUSIONS
Coxiella burnetii can initiate a CRMO. The mechanism involved is probably a delayed hypersensitivity. CRMO would therefore be the first type of reactive osteitis.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002348:Carpal Bones / Q000382:microbiology; D002675:Child, Preschool; D002908:Chronic Disease; D016997:Coxiella burnetii / Q000145:classification; D005260:Female; D005360:Fibula / Q000382:microbiology; D006801:Humans; D006811:Humerus / Q000382:microbiology; D010000:Osteitis / Q000382:microbiology*; D010019:Osteomyelitis / Q000382:microbiology*; D011778:Q Fever; D011884:Radius / Q000382:microbiology; D012008:Recurrence