Severe nonimmune hydrops fetalis and congenital corneal opacification secondary to human parvovirus B19 infection. A case report.
BACKGROUND
In parvovirus infections in animals, congenital anomalies are seen, but the teratogenic potential in humans seems fairly low.


METHODS
A fetus with hydrops, ascites and pleural effusion was seen at a prenatal ultrasound examination. Fetal cordocentesis was performed, and fetal blood was positive for parvovirus antibodies. Intravascular fetal blood transfusion was given at 21 and 23 weeks of gestation. At 39 weeks labor started spontaneously, and a 2,960-g, female infant was delivered. The newborn had bilateral opacification of the cornea.


CONCLUSIONS
In this case a combination of fetal parvovirus B19 infection and congenital corneal opacification was seen. This case also demonstrates that blood transfusions in hydropic fetuses may reverse the hydrops and prevent intrauterine death.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D001201:Ascites / Q000151:congenital* / Q000175:diagnosis / Q000821:virology*; D001803:Blood Transfusion; D003318:Corneal Opacity / Q000151:congenital* / Q000175:diagnosis / Q000821:virology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005315:Fetal Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D016732:Parvovirus B19, Human / Q000276:immunology; D010996:Pleural Effusion / Q000151:congenital* / Q000175:diagnosis / Q000821:virology*; D016216:Ultrasonography, Prenatal