title: [Hepatotoxicity and formation of reactive oxygen species induced by microcystis aeruginosa toxin].
abstract: OBJECTIVE
  To study hepatotoxicity of Microsystis aeruginosa toxin (microcystin) and its prevention.
  
  
  METHODS
  Cytotoxicity and the formation of reactive oxygen species (ROS) of microcystin extracted water bloom were studied in rat liver cells of primary culture.
  
  
  RESULTS
  It was found that the release of lactic dehydrogenase (LDH) increased with a time- and dose-dependent pattern in the liver cells treated with microcystin, and a time- dependent formation of ROS also increased simultaneously. The antioxidant, desferrioxamine, could decrease the release of LDH and the formation of ROS in the liver cells treated with microcystin.
  
  
  CONCLUSIONS
  Microcystin has obvious hepatotoxicity and the formation of ROS may play a certain role in its toxic effect on the rat liver cells.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D052998:Microcystins; D046931:Microcystis / Q000378:metabolism; D010456:Peptides, Cyclic / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014873:Water Pollutants / Q000633:toxicity