title: Effect of environmental tobacco smoke on peak flow variability.
abstract: This study was undertaken to determine whether exposure to various indoor pollutants is associated with a higher prevalence of respiratory symptoms, a diagnosis of asthma, or more variable peak flow rates. Four hundred and twenty-six children aged 8-11 years in four junior schools at three locations recorded respiratory symptoms and diagnosis of asthma using the ISAAC questionnaire. Daily peak flow measurements were taken during two six-week periods (winter and summer). Symptoms in children with and without asthma were not related to gas fires, cookers, smokers, or pets in the home. However, the variability of lung function, expressed as the coefficient of variation, in all children was increased with a household smoker. Environmental tobacco smoke increases airways variability in children with and without asthma. Its effects were not apparent from a questionnaire completed by parents, and the coefficient of variation of serially measured peak flows was a more sensitive indicator of lung function.
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002648:Child; D005260:Female; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010366:Peak Expiratory Flow Rate; D011446:Prospective Studies; D012621:Seasons; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*