Possible theophylline toxicity during anesthesia.
Asthmatic patients who undergo outpatient anesthesia are typically prescribed one or more drugs for treatment. Some of these agents have narrow therapeutic ranges and are associated with potentially serious adverse reactions, toxic effects, or drug interactions. Various clinical signs of toxicity may be first uncovered during routine monitoring of an office anesthetic. The case reported here demonstrates the need for proper understanding of the asthmatic patient's medical history and an appreciation for the medications used to control the disease. A sudden cardiovascular event possibly related to drug toxicity is witnessed and treated in an asthmatic patient during intravenous sedation. A possible drug interaction with a non-asthmatic medication taken concomitantly by the patient is implicated and discussed. In addition to the case report, the broad classification of drugs employed for bronchial asthma and their effects is reviewed.
D000328:Adult; D000766:Anesthesia, Dental / Q000009:adverse effects*; D000772:Anesthesia, Local / Q000009:adverse effects*; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D001249:Asthma / Q000150:complications; D001993:Bronchodilator Agents / Q000009:adverse effects*; D017742:Dental Care for Chronically Ill; D003758:Dental Implantation, Endosseous; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008487:Medical History Taking; D013806:Theophylline / Q000009:adverse effects*; D018879:Ventricular Premature Complexes / Q000209:etiology*