title: A role for KATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla.
abstract: Reticulospinal sympathoexcitatory neurons of rostral ventrolateral medulla (RVL) are selectively excited by hypoxia to elevate arterial pressure (AP) and cerebral blood flow (rCBF), that are elements of the oxygen-conserving (diving) reflex. We investigated whether KATP+-channels participate in this. Tolbutamide and glibenclamide, KATP+-channel blockers, microinjected into RVL in anesthetized rats, dose-dependently and site-specifically elevated AP and rCBF and potentiated responses to hypoxemia. KATP+-channels may mediate hypoxic excitation of oxygen-sensing RVL neurons.
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005905:Glyburide / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology*; D008297:Male; D008526:Medulla Oblongata / Q000098:blood supply / Q000737:chemistry / Q000166:cytology*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012125:Respiratory Center / Q000098:blood supply / Q000737:chemistry / Q000166:cytology; D014044:Tolbutamide / Q000494:pharmacology