[Clinical study of eliminating dampness and removing blood stasis in treating coronary heart disease--the summary about serial study of blood stasis due to dampness].
OBJECTIVE
To elucidate the relationship between Dampness and blood stasis in patients with coronary heart disease (CHD).


METHODS
One hundred and twenty-eight CHD patients with Phlegm-Dampness Syndrome (PDS) and 69 with blood stasis syndrome (BSS) were chosen and treated by eliminating Dampness and removing blood stasis.


RESULTS
(1) CHD-PDS and -BSS possessed the similar changes on hemorheology, oxygen free radical, blood lipids and vascular active substance. (2) Both of these two methods could alleviate angina (effective rate was 88.3%, 89.9%), improve ischemic S-T segment changes in ECG obviously and reduce consumption of nitroglycerin significantly (P < 0.01), improve abnormal hemorheology obviously (P < 0.001), raise PGI2, SOD obviously (P < 0.01) and lowered TXA2, MDA, ANP, ET and blood lipids significantly (P < 0.001). (3) The two methods could regulate imbalanced state of PGI2/TXA2,SOD/MDA.


CONCLUSIONS
CHD-PDS and -BSS had similar pathologic basis or pathologic changes, could eliminate the Dampness also had possessed similar pharmacologic or pharmacodynamic action of removing blood stasis. According to this, the viewpoint of "blood stasis due to Dampness" might be proved from clinical aspect.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000097:blood / Q000145:classification / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D011464:Epoprostenol / Q000097:blood; D005260:Female; D018056:Hemorheology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood; D013928:Thromboxane A2 / Q000097:blood