title: A zebrafish homolog of the serum response factor gene is highly expressed in differentiating embryonic myocytes.
abstract: Serum response factor (SRF) was identified as an activity binding upon serum stimulation of HeLa cells to a motif known as the serum response element in the c-fos promoter. This element is also found in the regulatory regions of many muscle-specific genes. We have characterized srf expression during early zebrafish embryogenesis. In addition to low-level expression in many or even all cells, elevated levels of srf RNA and protein are transiently expressed in skeletal muscle lineages during their differentiation.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics*; D015723:Gene Library; D008969:Molecular Sequence Data; D018482:Muscle, Skeletal / Q000196:embryology* / Q000378:metabolism; D009687:Nuclear Proteins / Q000032:analysis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D026362:Serum Response Factor; D015027:Zebrafish / Q000235:genetics*