[The clinical study on treatment of hepatic fibrosis of hepatitis B by IFN-alpha 1 and Chinese medical preparation].
OBJECTIVE
To find the effective method of curing hepatic fibrosis of hepatitis B.


METHODS
Using interferon alpha 1 and Chinese medical preparation to treat patients with hepatic fibrosis of hepatitis B and the comprehensive indexes, including levels of laminin, precollagen type III and hyaluronic acid, liver puncture, ultrasonographic and fiber-gastroscopic examination were observed before and after treatment.


RESULTS
After 3 months of treatment, the fibrotic indexes lowered obviously, in comparing with those before treatment, the difference was significant (P < 0.001). Liver biopsy, B-type ultrasonographic and fiber-gastroscopic examination proved that the hepatofibrosis was improved. The hepato-fibrotic indexes, blood albumin and globulin level were re-examined after 6 months, results showed that the difference between the IFN-effective group and the IFN-ineffective group was significant, P < 0.001.


CONCLUSIONS
Beneficial effect might be obtained by using IFN-alpha 1 to suppress the replication of hepatitis B virus and Chinese medical preparation to treat hepatic fibrosis.
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D019694:Hepatitis B, Chronic / Q000150:complications / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins