Antiviral efficacy of disinfectant solution MRI-1.
Disinfectant MRI-1 was prepared by dissolution of non-ionic and ionic detergent in ethanol. The disinfectant inactivated extracellular and intracellular enveloped and non-enveloped viruses including herpes viruses, influenza A and human immunodeficiency disease virus in suspension or on surfaces by pre-exposure or post-exposure to the disinfectant; in addition, cells were disabled as potential hosts for viral infection using concentrations of MRI-1 which were 50-fold less than the operative concentration for disinfection. There was no evidence of in vitro mutagenicity using Salmonella typhimurium or sensitization or other adverse effect in a guinea pig model or in human subjects.
D000818:Animals; D002417:Cattle; D003902:Detergents / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D006168:Guinea Pigs; D006678:HIV / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013499:Surface Properties; D013501:Surface-Active Agents / Q000494:pharmacology; D014777:Virus Diseases / Q000821:virology; D014780:Viruses / Q000187:drug effects* / Q000254:growth & development