[Studies on neuro-immunologic regulation of senile rats by using the principle of replenishing qi and promoting blood circulation].
OBJECTIVE
To study the mechanism of delaying senility by using the principle of replenishing Qi and promoting blood circulation(RQPBC).


METHODS
The following determinations were carried out in the natural-senile animals which have Qi deficiency and blood stasis Syndrome(24 month old rat) after the treatment. Hemorheological indexes, brain noradrenaline (NE), adrenocorticotropine(ACTH), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells (NKC).


RESULTS
The senile rat's above indexes decreased obviously (control: young rats), and by using this principle, all indexes were improved respectively. But these indexes in the young rats cannot be changed by applying this principle.


CONCLUSIONS
The results indicated that this principle could improve senile body's regulation of neuro-immuno endocrinologic network and keep homeostasis.
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000375:Aging / Q000187:drug effects / Q000276:immunology; D000818:Animals; D001921:Brain / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D018056:Hemorheology; D006854:Hydrocortisone / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D019413:Qi; D051381:Rats; D016711:Yang Deficiency / Q000276:immunology