title: [Effects of plendil on serum oxygen free radicals and insulin resistance in patients with essential hypertension].
abstract: To evaluate the effects of plendia on oxygen free radicals and insulin resistance in patients with essential hypertension, thirty non-obesive moderate hypertensive patients were treated with plendil for 30 days. Antihypertensive effect and effects on serum lipid peroxide (LPO), superoxide dismutase (SOD), insulin sensitivity index (ISI) were studied. Results showed: 1. SOD activity and ISI decreased but contents of LPO and insulin increased in the treatment group. After a course of plendil therapy the above mentioned parameters fell to normal ranges. 2. Plendil had obvious antihypertensive effect but with no significant changes in heart rate. 3. Plendil had no significant effect on fasting blood glucose and lipids. Plendia was an effective and safe drug for treatment of essential hypertension. It also had the effects of antioxidation which improved the sensitivity to insulin.
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D015736:Felodipine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007333:Insulin Resistance; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood