title: Attempting to control mite allergens with mechanical ventilation and dehumidification in British houses.
abstract: BACKGROUND
  Allergen avoidance is of considerable interest in the treatment and even prevention of asthma. Attempts to control house dust mites have included environmental manipulation in homes in an attempt to reduce humidity below a level that favors mite survival. This appears to have some benefit in Scandinavia, but a previous attempt with mechanical ventilation heat pump recovery (MVHR) units in the UK failed to achieve the desired results.
  
  
  OBJECTIVE
  We report a study using an additional central dehumidification modification of the MVHR (MVHRcd) in an attempt to reduce allergen levels in houses of asthmatic subjects.
  
  
  METHODS
  Ten houses of asthmatic patients allergic to dust mites and 10 architectural control houses were studied. The active houses were fitted with an MVHRcd unit in November/December 1994 and activated in January 1995. The active and control houses were monitored continuously for internal temperature and humidity by using digital sensors in the asthmatic and control bedrooms. Dust samples were collected to determine allergen levels at baseline (January 1994) and 3, 6, 9, and 15 months after switching on the units.
  
  
  RESULTS
  The winter seasonal average humidity fell from 50% relative humidity (RH) in control bedrooms to 37% RH in asthmatic bedrooms compared with 72% RH in the ambient air as measured on the intake of the MVHRcd systems. There was no corresponding change in seasonal mean temperature within the houses. Although the temperature and humidity weekly and seasonal means remained below the study target of 45% RH or 7 g/kg absolute humidity at 21 degrees C, there were transient rises in humidity detected by the sensors in the houses with MVHRcd systems. Allergen levels fell both in active and control houses during the study period, but there was no significant advantage gained from the installation of MVHRcd systems.
  
  
  CONCLUSIONS
  The MVHRcd system failed to confer a benefit in terms of mite allergen reduction despite apparently adequate control of temperature and humidity.
mesh_terms: D016902:Air Pollution, Indoor / Q000517:prevention & control*; D000485:Allergens / Q000032:analysis / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000517:prevention & control*; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000517:prevention & control; D006801:Humans; D006813:Humidity / Q000517:prevention & control*; D008925:Mites / Q000276:immunology; D012121:Respiration, Artificial; D011795:Surveys and Questionnaires; D013696:Temperature; D006113:United Kingdom / Q000453:epidemiology