Pentachlorophenol exposure in women with gynecological and endocrine dysfunction.
Exposure to wood preservatives containing pentachlorophenol (PCP) was detected in 65 women who consulted the Endocrinological Department of the University Hospital of Obstetrics and Gynecology, Heidelberg, Germany, because of gynecological problems. Blood PCP levels ranged from 20.7 to 133 microg per liter of serum. One hundred and six women with similar clinical conditions, corresponding age and body weight, no PCP exposure in history, and PCP levels below 20 microg per liter of serum served as control group. Significant associations were found between serum PCP concentrations, age, and different parameters of the endocrine system. PCP may act centrally on a hypothalamic or suprahypothalamic level which may result in mild ovarian and adrenal insufficiency. PCP may, therefore, play a role in the increasing infertility problem.
D000305:Adrenal Cortex Hormones / Q000097:blood; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000367:Age Factors; D004700:Endocrine System Diseases / Q000097:blood* / Q000139:chemically induced; D004781:Environmental Exposure; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood* / Q000139:chemically induced; D005858:Germany; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000139:chemically induced; D016555:Matched-Pair Analysis; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010416:Pentachlorophenol / Q000009:adverse effects* / Q000097:blood; D011247:Pregnancy; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism; D013963:Thyroid Hormones / Q000097:blood