[Protection mechanism of huanshaodan decoction in the brain].
OBJECTIVE
To observe the protective effect of Huanshaodan (HSD) in mouse brain in a steady ischemia-reperfusion model.


METHODS
Step-through experiment, receptor binding test and choline acetyl-transferase (CAT) activity determination was performed.


RESULTS
After HSD treatment, mice made much less mistakes in step-through experiment than sham groups. Meanwhile the 3H-MK801 binding of cerebral cortex and hippocampus tissues was significantly decreased. CAT activity of cerebral cortex and hippocampus tissue were increased respectively.


CONCLUSIONS
HSD might antagonize ischemia injury of brain through modulating excessive activation of glutamate N-methyl-D-Aspartic acid receptors.
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism*