title: Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome.
abstract: OBJECTIVE
  To report a case of Cogan-Reese syndrome.
  
  
  METHODS
  Case report. A 37-year-old man presented with Cogan-Reese syndrome.
  
  
  RESULTS
  Visual acuity was 0.5 in the right eye and 1.0 in the left eye. There were corneal edema and pigmented nodules on the anterior surface of the iris, iris atrophy and ectropion uvea in the right eye. The intraocular pressure was 42 mmHg in the right eye and there was glaucomatous optic atrophy of the optic disk. Trabeculectomy with mitomycin C has been performed as the intraocular pressure did not decrease with the maximum medical treatment. Electron microscopic examination of the trabeculum and the iris tissue revealed a lot of melanocytic cells in the stroma.
  
  
  CONCLUSIONS
  Trabeculectomy with mitomycin C might be effective in Cogan-Reese cases with glaucoma resistant to medical treatment.
mesh_terms: D000328:Adult; D015715:Corneal Edema / Q000150:complications / Q000473:pathology*; D005901:Glaucoma / Q000209:etiology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D015811:Iris Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use; D009508:Nevus, Pigmented / Q000150:complications / Q000473:pathology*; D013577:Syndrome; D014130:Trabeculectomy; D014792:Visual Acuity