DNA structure and transcription.
Regulation of transcription occurs through complex interactions of RNA polymerase and accessory proteins with specific DNA sequences and with each other. The DNA template topology influences the interaction of RNA polymerase with the promoter and its response to repressors, activators and the intracellular milieu through the formation of altered DNA structures or of nucleoprotein complexes. Recent developments on the role of DNA structures in transcription regulation are discussed.
D004247:DNA / Q000737:chemistry*; D005786:Gene Expression Regulation; D009690:Nucleic Acid Conformation; D014158:Transcription, Genetic