[Effect of allitridi on expression of proliferating cell nuclear antigen of cultured rabbit aortic smooth muscle cell].
OBJECTIVE
To observe the effect of allitridi on the expression of proliferating cell nuclear antigen (PCNA) of cultured rabbit aortic smooth muscle cell (SMC).


METHODS
The expression of PCNA was examined with immunohistochemical technique (LSAB method) and the contents of superoxide dismutase (SOD), lipid peroxide (LPO), prostacyclin (PGI2) and cyclic adenosine monophosphate (cAMP) in medium were simultaneously determined.


RESULTS
Allitridi has the effects of increasing SOD activity, decreasing LPO, elevating PGI2 and cAMP, reducing the expression of PCNA (all P < 0.05-0.01).


CONCLUSIONS
Allitridi could inhibit SMC proliferation.
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000378:metabolism; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism