Lipoproteins, atherogenicity, age and risk of myocardial infarction.
OBJECTIVE
To perform basic statistical analysis of laboratory lipoprotein data, i.e. the measures of very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL), to assist in their interpretation. In particular, to find any difference in male and female data that might explain the known difference in atherogenic susceptibility between the sexes.


METHODS
The study subjects were patients of doctors in city and country New South Wales. Statistical methodology to find the inter-relations of the lipoproteins was the construction of the matrix of correlation, then by matrix algebra to display the independent trends in the data.


CONCLUSIONS
The findings have been an atherogenicity function involving LDL and HDL and a risk function of myocardial infarction (MI) involving LDL, HDL and age, confirmed by reference to the age and sex incidence of MI in the Australian population. The principal conclusion is a simple mathematical model of the incidence of MI.


CONCLUSIONS
The means given for identification of at-risk individuals before symptoms appear, also the means given of lowering whole population risk of MI by health education and lifestyle change with increased longevity for all. These concepts call for a prospective trial.
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D003625:Data Collection; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008075:Lipoproteins, HDL / Q000009:adverse effects / Q000032:analysis*; D008077:Lipoproteins, LDL / Q000009:adverse effects / Q000032:analysis*; D008079:Lipoproteins, VLDL / Q000009:adverse effects / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D009517:New South Wales / Q000453:epidemiology; D018570:Risk Assessment; D017678:Sex Distribution; D015996:Survival Rate