Ultrasound biomicroscopical study of the irido-corneal angle in dominant juvenile open-angle glaucoma, in POAG, and in normal eyes.
OBJECTIVE
To compare various parameters of the chamber angle in a pedigree with dominant goniodysgenesis and juvenile open-angle glaucoma linked to chromosome 1q, GLC1A, with those in patients with adult-onset primary open-angle glaucoma, and in normal eyes.


METHODS
Ultrasound biomicroscopy was performed on 10 eyes with dominant goniodysgenesis and juvenile open-angle glaucoma, on 12 eyes with adult-onset primary open-angle glaucoma, and 24 normal eyes. Eight parameters were measured.


RESULTS
The anterior chamber angle, angle opening distance 500 microm from the scleral spur, trabecular meshwork--iris distance, and trabecular meshwork--iris pigment epithelium distance were statistically significantly higher in the group with juvenile glaucoma.


CONCLUSIONS
The wider chamber angle in dominant juvenile open-angle glaucoma could suggest a more complex anomaly with involvement of cornea and iris in addition to goniodysgenesis. The presence of goniodysgenesis in the dominant juvenile open-angle glaucoma patients could not be detected by ultrasound biomicroscopy, however.
D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000000981:diagnostic imaging*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003315:Cornea / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging* / Q000235:genetics*; D006801:Humans; D007498:Iris / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014129:Trabecular Meshwork / Q000000981:diagnostic imaging; D014463:Ultrasonography