Mimotopes of cytolytic T lymphocytes in cancer immunotherapy.
Rapid identification of the cytolytic T lymphocyte (CTL) epitopes that are presented by cancer cells will provide the basis for manipulation of tumor immunity but remains a major challenge in the field. By screening randomly synthesized peptide libraries, mimotopes for tumor-reactive CTLs can be readily constructed and they may be functionally equal to or potentially more potent than natural peptides in stimulating CTL responses; therefore, the peptide library approach provides great promise for design of cancer vaccines and adoptive tumor immunotherapy.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D018984:Epitopes, T-Lymphocyte; D006801:Humans; D007114:Immunization; D016219:Immunotherapy, Adoptive; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*