title: Enhanced neural regeneration from transected vagus nerve terminal in diabetic mice in vitro.
abstract: This study examined the effect of diabetes on neural regeneration in vitro. Nodose ganglia (NG) with vagal nerve fibers, dissected from streptozotocin-induced diabetic and normal C57BL/6J mice were embedded in collagen gel. After 3 and 7 days in culture, the numbers of regenerating neurites from transected nerve terminals of NG in diabetic mice were significantly greater than those in controls. Although many studies have revealed diabetes-associated impairment in neural regeneration, the results in the present study suggest that experimental diabetes could induce the potential to enhance regenerative capability of vagal sensory nerves after axotomy.
mesh_terms: D000818:Animals; D003714:Denervation; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009411:Nerve Endings / Q000503:physiopathology*; D009416:Nerve Regeneration / Q000502:physiology*; D016501:Neurites / Q000502:physiology; D012016:Reference Values; D014630:Vagus Nerve / Q000503:physiopathology*