Synthesis and antibacterial activity of 1 beta-methylcarbapenem having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety, Part II.
The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-4-one moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria are tested and the effect of substituent on the bicyclic ring was investigated. A particular compound (11 h) having aminoethyl group showed the most potent antibacterial activity.
D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship