[Effect of yifei kangliu yin on lung cancer metastasis and immune function].
OBJECTIVE
To explore the effect of Yifei Kangliu Yin (YFKLY) on metastasis of lung cancer and immune function.


METHODS
(1) Observing remote metastasis of three groups (n = 94) lung cancer patients, measuring the activity of NK cell, and the levels of OKT3, OKT4 of the patients by radioimmunoassay, and doing compared analysis. (2) Observing the effect of YFKLY on C57 mice B16 melanoma, and examining T4, T8 around the foci of cancer metastasis by immunohistochemical method.


RESULTS
YFKLY significantly reduced the incidence of remote metastasis in patients and reduced the metastasis foci numbers on C57 mice of B16 melanoma. It was found that NK cell activities, OKT3 and OKT4 in peripheral blood of patients significantly increased, the infiltration of T4 lymphocytes around the foci of cancer metastasis also increased.


CONCLUSIONS
YFKLY had inhibitory effect on the metastasis of cancer cells. It had strengthened the immune functions, aroused the anti-tumor capability.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000276:immunology / Q000556:secondary; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000818:Animals; D016516:CD4-CD8 Ratio; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000276:immunology / Q000556:secondary*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged