title: Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial.
abstract: Aloe vera has been used for centuries as a topical treatment for various conditions and as a cathartic. An amorphous hydrogel dressing derived from the aloe plant (Carrasyn Gel Wound Dressing, Carrington Laboratories, Inc., Irving, TX) is approved by the Food and Drug Administration for the management of Stages I through IV pressure ulcers. To evaluate effectiveness of this treatment, 30 patients were randomized to receive either daily topical application of the hydrogel study dressing (acemannan hydrogel wound dressing) or a moist saline gauze dressing. Complete healing of the study ulcer occurred in 19 of 30 subjects (63%) during the 10-week observation period. No difference was observed in complete healing between the experimental and the control groups (odds ratio 0.93, 95% CI 0.16, 5.2). This study indicates that the acemannan hydrogel dressing is as effective as, but is not superior to, a moist saline gauze wound dressing for the management of pressure ulcers.
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000627:therapeutic use*; D008297:Male; D008351:Mannans / Q000627:therapeutic use*; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D003668:Pressure Ulcer / Q000188:drug therapy*; D012965:Sodium Chloride / Q000627:therapeutic use*; D014945:Wound Healing