[Effect of jishentang on renal lesions in diabetic rats].
OBJECTIVE
To observe the ameliorative effect of Jishentang (JST) on renal lesions in experimental diabetic rats.


METHODS
The diabetic rats were randomly divided into three groups: group with out treatment, group with enalapril treatment (the dose of enalapril was 1 mg/kg.d) and group with JST treatment (the dose of JST was 22.4 g/kg.d). The treatment lasted for 8 weeks.


RESULTS
(1) JST treatment attenuated the renal hypertrophy and ratio of kidney and body weight (P < 0.01). (2) JST treatment reduced the levels of SCr and BUN and the levels of Alb, beta 2-m and the activity of NAG in urine in diabetic rats significantly (P < 0.01). The levels of TG and TCh decreased and the levels of HDL-C increased in the serum of the JST treated diabetic rats (P < 0.01). (3) The glomerular basement membrane thickening and volume density of PAS positive staining in mesangial area were significantly decreased in JST treated diabetic rats.


CONCLUSIONS
JST exerted obvious ameliorative effect on renal function and structure in diabetic rats.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D001613:beta 2-Microglobulin / Q000378:metabolism