Physiologic effects of intense MR imaging gradient fields.
The strength duration relationship for peripheral nerve stimulation by MR imaging pulsed gradient magnetic fields was measured in 84 human subjects. The data were fitted to the hyperbolic strength-duration relationship: dB/dt=b(1 + c/d), where b is rheobase, c is chronaxie, and d is duration, and dB/dt is reported as the maximal value on the axis of the bore. For sensation threshold, average (b,c) (15 T/s, 0.37 ms) for the y-gradient and (26 T/s, 0.38 ms) for the z-gradient coil. The dB/dt intensity to induce a sensation which the subject described as uncomfortable was about 50% above the sensation threshold. Experiments with dogs showed that the cardiac stimulation by pulsed magnetic gradient fields is exceedingly unlikely.
D000009:Abdominal Muscles / Q000502:physiology; D000328:Adult; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D008280:Magnetics / Q000009:adverse effects; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation; D010146:Pain / Q000209:etiology*; D017288:Pain Threshold / Q000502:physiology; D012119:Respiration; D012677:Sensation / Q000502:physiology*; D012684:Sensory Thresholds / Q000502:physiology; D013909:Thorax / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology