[Effect of migao xinle droplet pills on free radicals and serum nitric oxide on myocardial ischemia reperfusion injury in rats].
OBJECTIVE
To observe the protective effects of Migao Xinle Droplet Pills (MXLDP) on experimental myocardial injury induced by ischemia and reperfusion in rat on the basis of the cytoprotection theory.


METHODS
Studied the clearance capacity of MXLDP to oxygen free radicals and the contents of serum nitric oxide (NO) on the myocardial ischemia reperfusion injury model was produced by the 45 min ligation of left descending coronary artery and reperfusion in rats.


RESULTS
MXLDP pretreatment (30 and 120 mg.kg-1.d-1) prevented significantly reduction of myocardial superoxide dismutase (SOD) activity, reduced malondialdehyde (MDA) content and myocardial creatine phosphokinase (CPK) release; diminished significantly myocardial infarction size, decreased lactate dehydrogenase (LDH) activity and increased the concentration of serum NO in comparison with the control (P < 0.05-0.01).


CONCLUSIONS
It has a protective effect on myocardial ischemia/reperfusion injury. The action is considered to be related to the inhibition of the oxygen free radicals and subsequent lipid peroxidation as well as prevented reduction of NO.
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*