[Preliminary studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in Chinese women].
The relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis were studied. The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 162 healthy postmenopausal women and 17 patients with osteoporosis. The genotype frequencies of VDR were calculated later with Hardy-Weinberg equilibrium formula. The results showed that in controls, the bb, Bb, and BB genotype accounted for 91.36%, 8.64%, and 0% respectively. Of those patients with osteoporosis, they were 82.35%, 17.65%, and 0% respectively. The results suggested that there was no association between VDR genotype and osteoporosis noticed.
D044466:Asian People; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*