Pain related behaviour during vincristine-induced neuropathy in rats.
The development of suitable animal models of neuropathic pain is essential to understand the pathophysiological mechanisms responsible for this condition. This study presents the alterations in nociception observed in rats suffering from a peripheral neuropathy induced by 10 daily repeated intravenous injections of vincristine at doses of 50 or 75 microg/kg (total dose 500 or 750 microg/ kg). The rats present both mechanical hyperalgesia, allodynia and a loss of sensitivity (thermal hypoalgesia). Conservation of good health, the fast appearance of symptoms which correspond well with human responses and the easy induction of nociceptive symptoms are favourable criteria for using this model at 50 microg/kg vincristine dose in the future.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000209:etiology* / Q000503:physiopathology; D006987:Hypesthesia / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000523:psychology; D017288:Pain Threshold / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014750:Vincristine / Q000008:administration & dosage / Q000633:toxicity