[Studies of mechanism of erythrocyte deformability injury during hypobaric hypoxia in rats].
Rats were randomized into sea level group and hyoxic group. Erythrocyte filtration index (IF), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), erythrocyte [pH]i, [Mg2-]i, [Ca2+]i and [K+]i/[Na+]i were investigated in our studies. The results were as follows: 1. IF was increared in hypoxic group (0.234 +/- 0.060) 2. [Ca2+]i of hypoxic group (7.02 +/- 1.66) was evidently increased and correlated with its IF (r = 0.7386, P < 0.01), but [Mg2+]i had no obvious changes, [K+]i/ [Na+]i ratio of hypoxic group was reduced and negatively correlated with IF (r = -0.3957, P < 0.05), meanwhile, [pH] of hypoxic group increased evidently. 3. There was no statistic difference between MCHC of hypoxic and sea level group, but MCV of hypoxic group increased. These findings suggest that the changes of [Ca2+]i, [K+]i/[Na+]i ratio, [pH]i and MCV may play important role in erythrocyte deformability injury during hypoxia.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004907:Erythrocyte Deformability / Q000502:physiology*; D004909:Erythrocyte Indices; D005260:Female; D000860:Hypoxia / Q000097:blood* / Q000209:etiology; D008297:Male; D011188:Potassium / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism