[Effect of 2,4-D ecotoxicants on spermatogenesis and fertility of albino rats].
Characteristics of spermatogenesis, morphometric changes in the Leydig's and Sertoli's cells, and fertility of albino rats exposed to various doses of 2.4-D were investigated. Chronic injection of the herbicide led to transitional sterility against pronounced disorders of spermatogenesis, hyperplasia of sertolicytes and predominance of low-active forms of the Leydig's cells. An assumption concerning possible role of altered gonadostat in genesis of the reproductive disorders is offered.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D005298:Fertility / Q000187:drug effects*; D005500:Follow-Up Studies; D006540:Herbicides / Q000633:toxicity*; D006965:Hyperplasia / Q000473:pathology; D007985:Leydig Cells / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D012708:Sertoli Cells / Q000187:drug effects / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects*