title: Comparison of recovery of propofol and methohexital sedation using an infusion pump.
abstract: Two sedative anesthetic agents administered by an infusion pump were compared during third molar surgery. Forty American Society of Anesthesiologists (ASA) class I or II volunteers were randomly allocated to two groups. All subjects received supplemental oxygen via a nasal hood, fentanyl (0.0007 mg/kg intravenous [i.v.] bolus), and midazolam (1 mg/2 min) titrated to effect. Patients then received either 0.3 mg/kg of methohexital or 0.5 mg/kg of propofol via an infusion pump. Upon completion of the bolus, a continuous infusion of 0.05 mg/kg/min methohexital or 0.066 mg/kg/min propofol was administered throughout the procedure. Hemo-dynamic and respiratory parameters and psychomotor performance were compared for the two groups and no significant differences were found. The continuous infusion method maintained a steady level of sedation. Patients receiving propofol had a smoother sedation as judged by the surgeon and anesthetist.
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000295:instrumentation; D019162:Anesthetics, Combined / Q000008:administration & dosage; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007260:Infusion Pumps; D008723:Methohexital / Q000008:administration & dosage*; D008874:Midazolam / Q000008:administration & dosage; D008964:Molar, Third / Q000601:surgery; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D014081:Tooth Extraction