title: Increase in apoptosis and concomitant reduction of ischemic lesion volume and evidence for synaptogenesis after transient focal cerebral ischemia in rat treated with staurosporine.
abstract: We sought to determine whether induction of apoptosis alters an ischemic lesion. Rats were subjected to 2 h of middle cerebral artery occlusion (MCAo) and treated with staurosporine (n=8) or vehicle (n=4). Our data demonstrate that at 22 h after MCAo, staurosporine triggered a significant increase in apoptosis, a reduction of lesion volume and an increase of synaptophysin immunoreactivity, as compared to the control group.
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000473:pathology; D001921:Brain / Q000098:blood supply / Q000201:enzymology / Q000473:pathology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020287:In Situ Nick-End Labeling; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D019311:Staurosporine / Q000494:pharmacology*; D013569:Synapses / Q000473:pathology*