[Effects of tongxinluo capsule on hemodynamics and myocardial oxygen consumption in dogs].
OBJECTIVE
To observe the effects of Tongxinluo (TXL) capsule on hemodynamics and myocardial oxygen consumption in dogs.


METHODS
The coronary arterial arterial blood flow, cardiac output, left ventricular pressure, blood pressure, myocardial oxygen consumption of dogs were recorded by the polygraph system before and after intraduodenal administration of TXL.


RESULTS
TXL 0.72 g/kg increased obviously the coronary arterial blood flow by 21.56% after administration, and the left ventricular work was increased simultaneously, the difference was significant (P < 0.01) as compared with the control group.


CONCLUSIONS
TXL capsule could increase obviously the coronary arterial blood flow, dilate the coronary vessels, improve myocardial blood supply, increase left ventricular work, and result in the enhancement and readjustment of the "pump" function of heart and improvement of the intravascular stasis condition of blood circulation.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D008419:Materia Medica / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects*; D016277:Ventricular Function, Left / Q000187:drug effects