Mannitol and frusemide in the treatment of diuretic resistant oedema in nephrotic syndrome.
Three children (two girls aged 7 and 9 years, and one boy aged 4 years) with diuretic resistant oedema in steroid resistant nephrotic syndrome were treated with a combination of intravenous mannitol and frusemide. All three responded with loss of oedema of 10% to 30% of body weight over one week. There were no complications of hypertension or hypovolaemia. Mannitol-frusemide combination is a safe, inexpensive, and effective treatment for diuretic resistant oedema. Its use in other conditions and in developing countries (where the availability and purity of 20% albumin is limited) needs to be explored.
D002648:Child; D002675:Child, Preschool; D004232:Diuretics / Q000627:therapeutic use*; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008353:Mannitol / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000150:complications*