Intrapericardial streptokinase in purulent pericarditis.
Six consecutive children with proven purulent pericarditis were treated with pericardial irrigation with streptokinase. Mean (SD) 861 (678) ml (range 240-2000) of thick purulent fluid was drained, and five children had complete clearance of the pus within 3-8 days. One child developed intrapericardial haemorrhage with a submitral pseudoaneurysm and underwent patch closure of the neck of the aneurysm as well as anterior pericardiectomy. Follow up of 13 to 30 months revealed no pericardial constriction.
D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005069:Evaluation Studies as Topic; D006801:Humans; D007223:Infant; D007322:Instillation, Drug; D010493:Pericarditis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D010496:Pericardium / Q000000981:diagnostic imaging; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus; D013300:Streptokinase / Q000008:administration & dosage* / Q000627:therapeutic use; D015912:Thrombolytic Therapy