title: Effects of interstimulus interval on auditory event-related potentials in congenitally blind and normally sighted humans.
abstract: To test the hypothesis of auditory compensation after early visual deprivation, congenitally blind and sighted adults performed an auditory discrimination task. They had to detect a rare target tone among frequent standard tones. Stimuli were presented with different interstimulus intervals (ISIs) (200, 1000, 2000 ms) and the auditory-event related potentials to all tones and reaction times to targets were recorded. Increasing ISIs resulted in an increasing amplitude of the vertex response (N1-P2) in both groups, but this amplitude recovery was more pronounced in the blind. Furthermore, targets elicited larger and more posteriorly distributed N2 responses in the blind than in the sighted. Since target detection times were shorter in the blind as well, these findings imply compensatory adaptations within the auditory modality in humans blind from birth.
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D001766:Blindness / Q000151:congenital* / Q000503:physiopathology*; D004192:Discrimination, Psychological / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values