Alpha subunit of glycoprotein hormones in the sera of acromegalic patients and its mRNA in the tumors.
Within a population of 16 pituitary adenomas we found high levels of glycoprotein alpha subunits in the sera of patients with somatotrophic tumors. This finding was correlated with the presence of mRNA alpha subunit in these tumors indicating the adenomas themselves as the origin of the circulating alpha-subunit. Synthesis of these two hormones, which are chemically very different, by the same tumor cells indicates a high degree of differentiation of these cells. We are unable at this time to conclusively correlate differentiation of these tumors aggressively.
D000172:Acromegaly / Q000097:blood* / Q000209:etiology; D000236:Adenoma / Q000097:blood* / Q000150:complications / Q000378:metabolism; D015152:Blotting, Northern; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000235:genetics; D015292:Glycoprotein Hormones, alpha Subunit / Q000097:blood* / Q000235:genetics*; D019382:Human Growth Hormone / Q000097:blood / Q000235:genetics; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000235:genetics; D010911:Pituitary Neoplasms / Q000097:blood* / Q000150:complications / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D013972:Thyrotropin / Q000097:blood / Q000235:genetics