title: Changes of activity of liver glycogen synthase in experimental diabetes mellitus rats.
abstract: OBJECTIVE
  To study the activity of liver glycogen synthase in analogous model of NIDDM rats.
  
  
  METHODS
  Male Wistar rats were injected with low dose of streptozotocin (STZ) (30 mg/kg body weight) via tail vena and those animals with glucose tolerance impaired and level of insulin equal to or higher than that of the controls at 18th week were taken as the analogous rat model of NIDDM. The activity of liver glycogen synthase (GS) was assayed at the end of experiment.
  
  
  RESULTS
  Type I-enzyme: 0.18 +/- 0.06 mumol/min.g versus 0.24 +/- 0.09 mumol/min.g, P < 0.05, and total-enzyme: 1.52 +/- 0.43 mumol/min. g versus 1.84 +/- 0.42 mumol/min.g, P < 0.05.
  
  
  CONCLUSIONS
  The GS activity of diabetic rats was significantly lower than that of control.
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology* / Q000209:etiology; D005947:Glucose / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar