Peripheral T cell survival.
T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficiently characterized, but MHC-restricted interactions are not necessary.
D000818:Animals; D002470:Cell Survival; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors / Q000502:physiology; D007156:Immunologic Memory; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*