Cancer incidence among Finnish psoriasis patients treated with 8-methoxypsoralen bath PUVA.
BACKGROUND
Long-term oral 8-methoxypsoralen (8-MOP) and UVA (PUVA) therapy increases the risk of nonmelanoma skin cancer and possibly also of cutaneous malignant melanoma. Topical application of 8-MOP PUVA induces malignant tumors in rodent skin, but little is known about its carcinogenicity in human skin.


OBJECTIVE
Our purpose was to investigate the carcinogenicity of 8-MOP bath PUVA in humans.


METHODS
This was a cohort study of 158 patients with psoriasis, for whom 8-MOP bath PUVA had been initiated during 1979 to 1992. The average number of 8-MOP bath PUVA treatments was 36 (range, 6 to 204) and the mean cumulative UVA dose was 92 J/cm2 (range, 3 to 884 J/cm2) by the end of 1995. The patients were not treated with any other forms of PUVA. Cancer incidence subsequent to 8-MOP bath PUVA up to the end of 1995 was determined by linking the cohort with the records of the Finnish Cancer Registry. The standardized incidence ratios (SIR) were calculated for skin cancer and some common internal cancers, using the expected numbers of cases based on the regional cancer incidence rates.


RESULTS
There was one case of basal cell carcinoma, but no cases of other types of skin cancer. A total of 6 noncutaneous cancers were observed (SIR, 1.3; 95% confidence interval, 0.5 to 2.8).


CONCLUSIONS
No association between cutaneous cancer and 8-MOP bath PUVA was found, but the statistical power of this study alone is not adequate to warrant definite conclusions. The results can be used in a meta-analysis as soon as other studies on the carcinogenicity of 8-MOP bath PUVA are published.
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001494:Baths; D002280:Basal Cell Carcinoma / Q000209:etiology; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008498:Medical Record Linkage; D008545:Melanoma / Q000209:etiology; D008730:Methoxsalen / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011701:PUVA Therapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*; D011829:Radiation Dosage; D012042:Registries; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*