[Study on antimutagenic effect of lanthanum carbonate in CA test, UDS test and MN test].
Antimutagenic effect of Lanthanum carbonate [La2 (CO3)3] has been evaluated by means of unscheduled DNA synthesis (UDS) test, chromosomal aberration (CA) test in vitro human embryofibroblast (HEF) and micronucleus (MN) test in mouse bonemarrow polychromatic erythrocyte (PCE) induced by four different mutagens, i.e., short wave ultraviolet (UV), hydrochloric acid nitrogen mustard (NH2HCl), arsenic sodium oxide (NaAsO2) and cyclophosphamide (CP). The results of this study indicated that the antimutagenic effect of La2(CO3)3 was obvious in multiple antimutagenic systems in which mutation was induced by UV, NH2HCl and CP, but the effect of La2(CO3)3 on the decrease of CA frequencies induced by NaAsO2 had no statistical significance.
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide; D004622:Embryo, Mammalian; D005347:Fibroblasts; D006801:Humans; D007811:Lanthanum / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009588:Nitrogen Mustard Compounds; D014466:Ultraviolet Rays