[Antimutagenic mechanism of kiwifruit juice].
OBJECTIVE
To observe the effects of kiwifruit juice on the mutagenicity induced by cyclophosphamide (CP) and the effects of biotransformation enzymes in rats.


METHODS
We measured the frequency of cells with micronuclei in binucleated lymphocytes and the activities of liver glutathione-S-transferase (GST), uridine diphosphate glucuronyltransfer (UDPGT), gamma-glutamyl transpeptidase (gamma-GT).


RESULTS
Kiwifruit juice inhibited the frequency of cytokinesis-blocked cells with micronuclei (MN) induced by CP in rat peripheral blood lymphocytes, and increased significantly the activity of liver GST and UDPGT. The rate of MN cells was significantly correlated negatively with the activity of liver GST and UDPGT.


CONCLUSIONS
The effects of kiwifruit juice on anti-micronucleus formation may be related to the increased activities of detoxidation enzymes.
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide; D005638:Fruit; D005982:Glutathione Transferase / Q000378:metabolism; D008214:Lymphocytes; D008297:Male; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D005723:gamma-Glutamyltransferase / Q000378:metabolism