title: [Methodical approaches for establishing the values of spatial non-uniformity radiation coefficients for generalized dose calculation to evaluate immediate radiobiological effects].
abstract: The paper substantiates the key role of hemopoiesis damage in the character and severity of radiation reaction and survivability of the body shortly after exposure. The proposed model of equally effective dose takes into consideration modification of the radiobiological effect by spatial non-uniformity of radiation and allows reduction of the effects of non-uniform radiation to the standard uniform radiation. Described is the algorithm for calculating values of the equally effective dose and coefficients of spatial non-uniformity of space radiation required to determine the generalized dose and radiation risk for cosmonauts on extended missions.
mesh_terms: D000337:Aerospace Medicine; D000465:Algorithms; D000818:Animals; D018480:Astronauts; D004285:Dogs; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D051379:Mice; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000175:diagnosis / Q000517:prevention & control; D011833:Radiation Injuries, Experimental / Q000175:diagnosis / Q000517:prevention & control; D011874:Radiometry / Q000379:methods*