[Accumulative arsenic level in viscera in offsprings of exposed parent rats].
OBJECTIVE
To explore the metabolism and accumulation of arsenic in the offsprings of exposed rats.


METHODS
Arsenic contents in viscera of the rat offsprings, whose parents exposed to different dose of arsenic, were determined with a two-generation reproductive test.


RESULTS
Arsenic contents in the heart, liver, brain, kidney and spleen of the offsprings correlated with the dose their exposed parents, the highest in the spleen. There was significant difference in arsenic contents of the viscera between two generations of rats. Arsenic contents in the viscera of the offsprings declined significantly one month after stopping exposure to arsenic, but still higher than that in controls.


CONCLUSIONS
It suggests that arsenic can deposit in the bodies of the rat offsprings, and excreted from the bodies slowly.
D000818:Animals; D020261:Arsenic Poisoning; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000493:pharmacokinetics; D005260:Female; D008297:Male; D010087:Oxides / Q000493:pharmacokinetics / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism*; D014018:Tissue Distribution; D014781:Viscera / Q000378:metabolism