Diversity of inorganic arsenite biotransformation.
Biotransformation of inorganic arsenic in mammals is catalyzed by three serial enzyme activities: arsenate reductase, arsenite methyltransferase, and monomethylarsonate methyltransferase. Our laboratory has purified and characterized these enzymes in order to understand the mechanisms and elucidate the variations of the responses to arsenate/arsenite challenge. Our results indicate a marked deficiency and diversity of these enzyme activities in various animal species.
D000251:Adenosine Triphosphatases / Q000096:biosynthesis / Q000378:metabolism; D000818:Animals; D053501:Arsenite Transporting ATPases; D018053:Arsenites / Q000493:pharmacokinetics*; D001711:Biotransformation; D002384:Catalysis; D004790:Enzyme Induction; D016623:Ion Pumps; D008322:Mammals; D008745:Methylation; D008780:Methyltransferases / Q000096:biosynthesis / Q000378:metabolism; D009097:Multienzyme Complexes; D013045:Species Specificity