Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine.
Serotonin (5-HT) appears to play a modulatory role in the behavioral effects of cocaine, although the impact of 5-HT2C receptors in this control has not been fully established. The aim of the present study was to establish whether acute pretreatment with the selective 5-HT2C/2B antagonist SB 206553 (1, 2, and 4 mg/kg i.p.) altered hyperactivity induced by cocaine (15 mg/kg, i.p.) using an open field activity system which recorded central, peripheral, and rearing activity. Pretreatment with 1 and 2 mg/kg of SB 206553 attenuated cocaine-induced central and peripheral activity, respectively; rearing was also attenuated by the latter dose. However, the 4-mg/kg dose of SB 206553 significantly enhanced the effects of cocaine on peripheral activity. Based upon the present observations and an interpretation of previous research to implicate 5-HT2C receptor control of the dopamine (DA) mesoaccumbens pathways in behavior, a thorough and systematic analysis of the role of 5-HT2C (and 5-HT2B) receptors in psychostimulant-induced behaviors is warranted.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D006948:Hyperkinesis / Q000139:chemically induced / Q000517:prevention & control*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*