B cell memory and the long-lived plasma cell.
The germinal center reaction is pivotal to the induction of B cell memory. The signals that regulate this complex microenvironment, with their cellular and molecular consequences, underpin long-term protective immunity. Recent studies have identified many key regulators of the germinal center cycle and have revealed an array of cellular outcomes that further define the memory B cell compartment.
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D018858:Germinal Center / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification; D007156:Immunologic Memory; D010950:Plasma Cells / Q000502:physiology*