title: The PIK-related kinases intercept conventional signaling pathways.
abstract: Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. More recent data suggest that members of the family of PIK-related kinases act as intracellular sensors that govern radial and horizontal pathways. These pathways can impinge upon classical membrane to nuclear pathways, as well as components of the cell-cycle machinery.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D006801:Humans; D020104:Immunophilins / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor); D015398:Signal Transduction; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases