title: Homophilic adhesion by cadherins.
abstract: Cadherins mediate cell-cell adhesion through homophilic interactions. High-resolution structures have greatly enhanced our understanding of this phenomenon over the past few years. Nonetheless, some of the original concepts about cadherin interactions need revision, with the new structural and additional mutagenesis data currently available. Furthermore, in vivo studies on cadherins have provided supplementary information.
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D002448:Cell Adhesion / Q000502:physiology*; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D008958:Models, Molecular; D011487:Protein Conformation; D013237:Stereoisomerism