title: Equine nasal and paranasal sinus tumours: part 2: a contribution of 28 case reports.
abstract: The clinical and pathological findings of 28 cases (27 horses, 1 donkey) of equid sinonasal tumours examined at the Edinburgh Veterinary School are presented and include: seven cases of squamous cell carcinoma (SCC); five adenocarcinomas; three undifferentiated carcinomas; two adenomas; five fibro-osseous and bone tumours; and single cases of ameloblastoma, fibroma, fibrosarcoma, undifferentiated sarcoma, melanoma and lymphosarcoma. The median ages of animals affected with epithelial, and fibro-osseous/bone tumours were 14 and 4 years, respectively. Unilateral purulent or mucopurulent nasal discharge (81% of cases) and gross facial swellings (82% of cases) were the most common presenting signs with sinonasal tumours, with epistaxis recorded in just 23% of cases. Radiology and endoscopy were the most useful ancillary diagnostic techniques. The maxillary area was the most common site of tumour origin, and only three cases were definitively identified as originating in the nasal cavity. Four of the maxillary SCC lesions originated within the nasal cavities or maxillary sinuses, while two originated in the oral cavity. Fourteen of 15 carcinomas, but only two of the 13 remaining tumours, spread to other sites in the head. Only three cases of sinonasal tumour had lymph node metastases, and none had distant metastases. In the long term, surgical treatment with seven malignant tumours was unsuccessful (6 months median survival post-operatively), but was successful with four out of five benign tumours (no regrowth at a median of 4 years post-operatively).
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary; D000236:Adenoma / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary; D000818:Animals; D001859:Bone Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary; D005260:Female; D005500:Follow-Up Studies; D006734:Horse Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006736:Horses; D008297:Male; D009669:Nose Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy / Q000662:veterinary*; D012189:Retrospective Studies