Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-diprenorphine.
Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C-diprenorphine PET provides unique information for the understanding of central poststroke pain.
D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D002543:Cerebral Hemorrhage / Q000150:complications; D002544:Cerebral Infarction / Q000150:complications* / Q000378:metabolism; D002561:Cerebrovascular Disorders / Q000150:complications / Q000378:metabolism; D004174:Diprenorphine / Q000494:pharmacology; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain / Q000209:etiology* / Q000378:metabolism; D011149:Pons / Q000098:blood supply* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D011957:Receptors, Opioid / Q000378:metabolism*; D012678:Sensation Disorders / Q000209:etiology* / Q000378:metabolism; D014055:Tomography, Emission-Computed