[Significance of p16 and C-myc expression in the laryngeal squamous cell carcinoma].
OBJECTIVE
To study the clinical significance of p16 and C-myc expression in the laryngeal squamous cell carcinoma (LSCC).


METHODS
Immunohisto-chemical detection of p16 proteins and C-myc proteins, in 47 cases of LSCC and 6 cases of normal tissues from the larynx, were conducted in paraffin-embeded sections.


RESULTS
No staining was found in 6 cases of normal tissue; The positive expression of p16 and C-myc proteins expression rates did not correlate with sex, age and position of the tumors (P > 0.05); but related to the staging and grade of LSCC (P < 0.05). The expression of C-myc proteins were higher in the case with lymph nodal metastasis than that without lymph nodal metastasis (P < 0.05).


CONCLUSIONS
The expression of p16 and C-myc protein may play an important role in the development of LSCC, and may be a new indicator to assess the prognosis of LSCC.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*