[Effect of immune function xuanfa moyuan principle on immune arthritis (bizhen) in mice].
OBJECTIVE
To explore the effect of Xuanfa Moyuan principle ([symbol: see text], XFMYP) on arthritic mice.


METHODS
The type II collagen induced arthritis in DBA mice was taken as Bizheng ([symbol: see text]) animal model. The Dayuanyin ([symbol: see text], DYY) was taken as the representative prescription for XFMYP. The arthritis incidence and arthritis index were tested by scoring system. The anti-C II antibody IgG and its subsets, IgM rheumatoid factor, interferon gamma and interleukin 10 produced by lymph node cells were tested by ELISA method.


RESULTS
XFMYP could delay the onset day of arthritis, decrease the arthritic incidence and index, decrease anti-II IgG2a, IgG2b, IgG1 level and the IgG2a + IgG2b/IgG1 ratio in serum, decrease the production of interferon gamma by lymphocytes and increase the production of interleukin 10.


CONCLUSIONS
XFMYP could inhibit the anti-C II immune response, and balance the anti-C II Th1 and Th2 type immune responses.
D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000276:immunology*; D003094:Collagen / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012217:Rheumatoid Factor / Q000097:blood