title: Synthesis of antihypertensive agents via coupling reaction of benzothiazepinone and 1,4-dihydropyridine derivatives.
abstract: The synthesis of 3a, 3b, 7a and 7b from Benzothiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone and 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothiazepinone and 1,4-dihydropyridine derivatives.
mesh_terms: D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013841:Thiazepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology