[Effect of chaihu guizhi decoction on the immunoglobulin and IgG subgroup in children with recurrent respiratory tract infection].
OBJECTIVE
To observe the effect of Chaihu Guizhi Decoction (CGD) on Immunoglobulin (Ig) and IgG subgroup in children with recurrent respiratory tract infection (RRTI).


METHODS
Levels of Ig and IgG subgroup were measured in 23 cases of children with RRTI before and after treating with CGD, and compared with those in the control group.


RESULTS
In RRTI group, the levels of IgG, IgA, IgM and IgG1 were lower than those of the control groups respectively (P < 0.01). The rate of IgG subgroup deficiency (ISD) was 60.9%. The effective rate of the CGD group was 95.6%. The IgG and IgG1 levels were increased after treatment as compared with before treatment (P < 0.05), and the ISD correcting rate being 71.4%.


CONCLUSIONS
The hypoimmunofunction and IgG subgroup deficiency were important factors in RRTI pathogenesis. The CGD could improve the immunofunction and correct the IgG subgroup deficiency, and this effect might be one of the mechanism of CGD in treating RRTI.
D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000188:drug therapy; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification; D007223:Infant; D008297:Male; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000276:immunology*