title: Mitochondrial-matrix proteins at unexpected locations: are they exported?
abstract: Many proteins that were originally characterized on the basis of non-mitochondrial functions have unexpectedly been shown to be identical to mitochondrial-matrix proteins. Most of these proteins are encoded by single nuclear genes and are initially targeted to the mitochondrial matrix. We suggest that mitochondria, as organelles of bacterial origin, possess specific mechanisms for export of proteins to other compartments.
mesh_terms: D001219:Aspartate Aminotransferases / Q000378:metabolism; D001692:Biological Transport; D018835:Chaperonin 10 / Q000378:metabolism; D018834:Chaperonin 60 / Q000235:genetics / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D005649:Fumarate Hydratase / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D018960:Hyaluronan Receptors; D006904:Hydroxymethylglutaryl-CoA Synthase / Q000378:metabolism; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000378:metabolism