Pleiotropic changes controlled by the pre-T-cell receptor.
The construction of various gene-deficient mice has facilitated the understanding of the role of various receptors and signaling pathways that control the generation of alphabeta lineage cells. A predominant role is occupied by the pre-TCR, which not only generates large numbers of alphabeta lineage cells but also controls TCRbeta allelic exclusion as well as commitment to the gammadelta lineage versus the alphabeta lineage.
D000483:Alleles; D000818:Animals; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D051379:Mice; D011498:Protein Precursors / Q000502:physiology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000502:physiology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000502:physiology*