Subcorneal pustular dermatosis treated with PUVA therapy. A case report and review of the literature.
BACKGROUND
Subcorneal pustular dermatosis (SPD) is a chronic recurrent pustular dermatosis of unknown etiology. Many treatments have been proposed, none of which has been uniformly successful.


OBJECTIVE
Our purpose is to report a patient with SPD successfully treated by PUVA and to review the literature concerning phototherapy treatment of SPD.


METHODS
A patient suffering from SPD resistant to diaminodiphenylsulphone (dapsone) responded well to a combination therapy consisting of dapsone and PUVA. He received 50 mg/day and 3 PUVA sessions a week. Photographs were taken at baseline and after 15 sessions.


RESULTS
The lesions were virtually cleared after 15 sessions. The patient remained free of lesions with a maintenance therapy of dapsone (50 mg/ day) and 1 PUVA session a week.


CONCLUSIONS
The therapeutic value of phototherapy for the treatment of SPD still has to be confirmed and could be a valuable alternative for treatment-resistant patients.
D003622:Dapsone / Q000008:administration & dosage; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology