Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry.
Lewy bodies and coarse Lewy neurites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions are present in the axonal processes of neurons.
D001369:Axons / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000737:chemistry / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D016501:Neurites / Q000648:ultrastructure*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology*; D051843:Synucleins; D051844:alpha-Synuclein