title: Activation by locus control regions?
abstract: On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.
mesh_terms: D000818:Animals; D002875:Chromosomes; D017353:Gene Deletion; D018014:Gene Transfer Techniques; D005914:Globins / Q000235:genetics*; D006801:Humans; D019901:Locus Control Region; D013789:Thalassemia / Q000235:genetics; D019076:Transgenes