Hepatic sickling crisis mimicking recurrent cholangitis.
A 22-year-old man with homozygous sickle cell disease presented with recurrent fever, right upper quadrant pain and jaundice. Liver biopsy confirmed the diagnosis of hepatic sickling crisis; the symptoms responded to hydroxyurea therapy. Hepatic vasocclusive crisis can diagnosed on liver biopsy, and need not be a diagnosis of exclusion.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000473:pathology*; D002761:Cholangitis / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male