[Clinical and experimental study on treatment of fatty liver of phlegm-dampness stagnation type by zhiganle capsule].
OBJECTIVE
To explore the mechanism of Zhiganle capsule (ZGLC) in treating fatty liver of Phlegm-Dampness Stagnation type.


METHODS
One hundred and forty-six patients were treated with ZGLC, the effects were observed and compared with those treated with Dongbao Gantai (DBGT,) tablets as control. The effect of ZGLC on ethionine induced hyperlipemia model rats was also observed.


RESULTS
The effect of ZGLC was obviously better than those of DBGT in relieving or removing symptoms, normalizing the ultrasonic abnormal findings, lowering the serum levels of lipid and enzyme and improving hemorrheologic properties. Experimental study showed that ZGLC could reduce the blood lipids, inhibit the lipid deposition in liver. As compared with the model group, level of triglyceride in the ZGLC treatment group were much lowered (P < 0.01) and the effect was better than those in the control group.


CONCLUSIONS
ZGLC has the effect of reducing blood triglyceride level, inhibiting lipid deposition in liver and improving hemorrheologic properties.
D000328:Adult; D000368:Aged; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005234:Fatty Liver / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood