[Effect of boayuan qiangshen II tablet on plasma and urine superoxide dismutase and malondialdehyde in patients with chronic renal failure].
OBJECTIVE
To observe the effect of Chinese herbs of replenishing Kidney in treating chronic renal failure (CRF).


METHODS
Forty patients with CRF wrer randomly divided into two groups, Baoyuan Qiangshen (BQ) II tablet group and essential amino acid added capoten group. The changes of plasma and urine superoxide dismutase (SOD) and malondialdehyde (MDA) and the kidney function indices were investigated before and after treatment.


RESULTS
Before treatment, SOD reduced and MDA of both groups increased (P < 0.01), while urine SOD and MDA increased (P < 0.01). After treatment, plasma SOD increased but MDA was reduced and urine SOD, MDA were also reduced (P < 0.01). Although the BUN and serum creatinine reduced significantly, creatinine clearance rate elevated significantly (P < 0.01).


CONCLUSIONS
The BQ II tablet could strengthen antioxidation and inhibit lipid peroxidation, so it was effective to improve kidney function.
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*; D013607:Tablets