The development of vaccines against gastrointestinal nematode parasites, particularly Haemonchus contortus.
Many parasitic nematodes are developing resistance to chemical treatment, and the search is on to produce commercially viable molecular vaccines. Much progress has been made with highly protective 'hidden antigens', especially for Haemonchus contortus, and recent work with new 'natural antigens' has yielded promising results. Here, Sue Newton and Ed Munn review the most recent advances in these two main approaches to this problem.
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004064:Digestive System / Q000469:parasitology*; D006188:Haemonchiasis / Q000517:prevention & control*; D006189:Haemonchus / Q000276:immunology*; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000517:prevention & control*; D009348:Nematoda / Q000276:immunology; D009349:Nematode Infections / Q000469:parasitology / Q000517:prevention & control; D014612:Vaccines / Q000276:immunology*