[Experimental studying of the possible pharmacological defense of muscular flap tissues from ischemic and reperfusion injury during its free transplantation].
In experiment on muscle flaps of 20 rabbits the peculiarities of their tissues damage in the ischemia period, and also due to the oxygen-dependent processes activation (peroxidal and free radical oxidation of a membrane phospholipids) in period of its reperfusion were studied. Preliminary introduction of a lipin, unitiol and ascorbic acid mixture in the flap arterial channel had promoted the reduction of damage severity in the translocated flap cells biomembranes due to ischemia and reperfusion, causing inhibition of the lipids peroxidal oxidation processes, rising of the flap tissues antioxidant defense, the cell and subcell membranes stabilization which preserves the vessels endothelium integrity. This showed a promising future for application of these preparations in a free transplantation of compound tissue complexes.
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D018482:Muscle, Skeletal / Q000637:transplantation* / Q000648:ultrastructure; D009930:Organic Chemicals; D011817:Rabbits; D015427:Reperfusion Injury / Q000188:drug therapy*; D013524:Surgical Flaps / Q000098:blood supply; D014494:Unithiol / Q000627:therapeutic use