A possible dopaminergic mechanism in the serotonergic antidepressant-induced sexual dysfunctions.
The administration of antidepressant serotoninergic medication is associated with the presentation of sexual dysfunctions. This seems to be mediated by the activation of the 5-HT2 receptors. Segraves (1995) has proposed that the inhibition of noradrenergic transmission by serotonin may be the mechanism which causes the antidepressant-induced sexual dysfunctions. The inhibition which the 5-HT2 receptors carry out on dopaminergic transmission leads us to propose this mechanism as also participating in the antidepressant-induced sexual dysfunctions.
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009948:Orgasm / Q000187:drug effects; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced* / Q000378:metabolism*