[The anxiolytic activity of calcium-channel blockers in tests of anxious behavior in mice and rats].
The evidence obtained from the studies of the anxiolytic activity of calcium channel blockers in the tests for anxiety: dark-light chamber, elevated plus-maze, social interaction, incomplete sensory deprivation, and change in the excitability of the CNS is analyzed. Methodological aspects of studying the anxiolytic activity of drugs in these tests are discussed. The problems are considered related with simulation of the normal situational anxiety and pathological anxiety as well as the prospects of using the calcium channels blockers as anxiolytics. In view of these aspects, the problem of search for an "ideal" anxiolytic and possible results of revealing its activity in the tests for the normal and pathological anxiety are discussed.
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy* / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D051379:Mice; D051381:Rats; D012919:Social Behavior