Synthesis and properties of (6,7-dimethoxy-4-coumaryl)alanine: a fluorescent peptide label.
The synthesis of racemic and l-(6,7-dimethoxy-4-coumaryl)alanine (Dmca) is described and some spectral and physicochemical properties are reported. The utility of Dmca as a highly sensitive and specific label for the quantitative detection of synthetic peptides in HPLC and in minimal essential media (MEM) is also described.
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D008956:Models, Chemical; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet