[Quantitative change of glucagon and insulin immunoreactivities in the pancreas of fasting rats].
In this study, the glucagon and insulin immunoreactivities in the fasting rat pancreas were quantitated by image analysis. The results showed that the glucagon immunoreactivity significantly decreased in fasting rats and that of insulin increased, as compared with that in normal rats. The glucagon immunoreactivity significantly increased after intravenous injection of glucose but no marked difference was found in insulin. These results suggest that the A cells of pancreas may be directly stimulated by nutrients, and the B cells in a different way.
D000818:Animals; D005215:Fasting / Q000378:metabolism / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley