A study on continuous low-flow perfusion with low-potassium dextran for donor isolated lung preservation.
OBJECTIVE
To test the validity of continuous low-flow perfusion with low-potassium dextran (LPD) to preserve rabbit lung.


METHODS
Isolated rabbit lungs were preserved for eight hours either in Ringer's solution by simple storage (Group I) or in continuous low-flow perfusion with LPD (Group II). After preservation, lung functions were assessed to compare these two methods.


RESULTS
The water gain in Group I was higher than that in Group II. During reperfusion, the functional test values for the immersed lungs were lower than those for the perfused lungs. The lipid peroxidation product (MDA) was significantly decreased in perfused lungs during reperfusion.


CONCLUSIONS
Low-flow perfusion with LPD is better than immersion for the lung preservation.
D000818:Animals; D003911:Dextrans; D066298:In Vitro Techniques; D008168:Lung; D008297:Male; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D010477:Perfusion; D011188:Potassium; D011817:Rabbits