Renal hemodynamic effects of nabumetone, sulindac, and placebo in patients with osteoarthritis.
We assessed the effects of nabumetone, sulindac, and placebo on renal function and renal excretion of vasodilatory prostaglandins in older female patients (age >50 years) with osteoarthritis and normal renal function. Using a prospective, crossover design, we compared the effects of nabumetone 2000 mg/d and sulindac 400 mg/d with placebo on glomerular filtration rate (GFR), renal plasma flow (RPF), and urinary excretion of prostaglandin E2 and 6-keto-prostaglandin F1alpha in 12 patients. Urinary excretion of vasodilatory prostaglandins was not decreased after 14 days of treatment with either nabumetone or sulindac. Likewise, treatment with nabumetone or sulindac did not significantly alter renal function compared with placebo. There were no differences in mean changes in GFR or RPF from baseline after treatment with nabumetone or sulindac compared with placebo. The mean (+/- SD) changes in GFR from baseline were 0%+/-8% in patients receiving nabumetone, -8%+/-15% in patients receiving sulindac, and -7%+/-15% in patients receiving placebo. The results of this study demonstrate that treatment with nabumetone or sulindac caused no deterioration in renal function in older female patients with osteoarthritis and normal renal function.
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D002074:Butanones / Q000494:pharmacology* / Q000627:therapeutic use; D018592:Cross-Over Studies; D015232:Dinoprostone / Q000652:urine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D000077430:Nabumetone; D010003:Osteoarthritis / Q000188:drug therapy* / Q000503:physiopathology* / Q000652:urine; D010919:Placebos; D011188:Potassium / Q000652:urine; D011446:Prospective Studies; D012079:Renal Circulation / Q000187:drug effects*; D012964:Sodium / Q000652:urine; D013467:Sulindac / Q000494:pharmacology* / Q000627:therapeutic use