title: Rare occurrence of colorectal cancer metastasis in livers infected with hepatitis B or C virus.
abstract: BACKGROUND
  The rarity of the occurrence of metastatic malignancy in injured liver has been noted by many observers. However, since the clinicopathological features of primary carcinoma and the etiology of liver disease of these patients vary greatly, this phenomenon may not be universal.
  
  
  METHODS
  We evaluated the relationship between either hepatitis B virus (HBV) or hepatitis C virus (HCV) infection and the incidence of colorectal liver metastasis in 438 patients undergoing surgical treatment for advanced colorectal carcinoma.
  
  
  RESULTS
  The liver function of the patients in the infection group (n = 37) was significantly worse than that of those in the noninfection group (n = 401). The incidences of tumor recurrence in the lung or peritoneum were comparable between the two groups. However, the percentage of patients with liver metastases in the infection group (3 of 37, 8.1%) was significantly lower (P <0.05) than that of those in the noninfection group (85 of 401, 21.2%). The patients in the infection group tended to survive longer than the patients in the noninfection group.
  
  
  CONCLUSIONS
  We herein report an initial finding that colorectal carcinoma rarely metastasizes to livers infected with HBV or HCV.
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000401:mortality / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity; D006509:Hepatitis B / Q000453:epidemiology*; D006515:Hepatitis B virus / Q000472:pathogenicity; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate