A new anti-tubulin agent containing the benzo[b]thiophene ring system.
A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6-methoxybe nzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D006868:Hydrolysis / Q000187:drug effects; D013876:Thiophenes / Q000737:chemistry*; D013997:Time Factors; D014404:Tubulin / Q000138:chemical synthesis* / Q000494:pharmacology; D050257:Tubulin Modulators; D014407:Tumor Cells, Cultured