title: [Development of vibration-induced intrahepatic cholestasis in pilots and new ways of correcting these disorders].
abstract: Data of analysis of the role of vibration in the development of hepatobiliary pathology in helicopter pilots are reported. Vibration was found to drastically deteriorate colloid-osmotic qualities of the bile and increase the lithogenesis risk. Exposure to vibration over 10 and more years of the flying career may instigate cholelithiasis. Dynamic USI with functional testing for early diagnostics and correction with ursodeoxycholic acid (ursosan) of disorders in the colloid-osmotic properties of the bile and can be proposed as one of the methods to prevent cholelithiasis.
mesh_terms: D000328:Adult; D000337:Aerospace Medicine; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002780:Cholestasis, Intrahepatic / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D009784:Occupational Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D014463:Ultrasonography; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D014732:Vibration / Q000009:adverse effects*