[Clinical study on modified sijunzi decoction in treating intestinal metaplasia of gastric mucosa].
OBJECTIVE
To investigate the effects of Modified Sijunzi decoction (MSJZD) in treating gastric pre-cancerous lesion.


METHODS
Two hundreds and two patients with chronic gastritis and intestinal metaplasia (IM) of gastric mucosa diagnosed by gastroscopy and pathological examination of biopsy were divided into 2 groups, 117 cases of the treatment group were treated with MSJZD and 85 cases of the control group were treated with Weimeisu. For both groups, re-examination was taken after a 3-month treatment.


RESULTS
The cure rate and total effective rate of IM in the treatment group were 55.6% and 87.2% respectively, while in the control group were 11.8% and 55.3% respectively (P < 0.01).


CONCLUSIONS
The intestinal metaplasia process of gastric mucosa is reversible and MSJZD has good effect on it. This study provided a new way of pre-cancerous lesion treatment and gastric cancer prevention.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000188:drug therapy; D008875:Middle Aged