[Association between levels of plasma lipid profile with apolipoprotein B gene polymorphism in 93 children].
OBJECTIVE
To study the relationship between levels of plasma lipid profile and variation of apolipoprotein (Apo) B gene.


METHODS
The relationship between frequency of polymorphism genotype of Apo B gene Xba I locus and levels of plasma lipid profile was studied in 93 children aged eight to eleven years.


RESULTS
The frequency of dominant X- allele (common allele) in Xba I locus was 0.967 in the children and that of uncommon X+ allele 0.033. Average levels of plasma total cholesterol (TC) and low density lipoprotein cholesterol (LDL-ch) in children with X- X+ genotype (4.59 and 2.98 mmol/L, respectively) were significantly higher than those with X-X- genotype (3.84 and 2.32 mmol/L, respectively). Levels of TC and/or LDL-ch in 4 of 6, cases of X-X+ genotype exceeded their the 90th percentile, indicating association between X+ allele and high plasma cholesterol level.


CONCLUSIONS
To certain extent, there is association between polymorphism of Xba I locus of Apo B gene and levels of plasma lipid profile in children, which may be a genetic marker for abnormal level of plasma lipid profile during childhood.
D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length