[Effect of taozhi zhipo granule on intestinal adhesion in rats and exploration of its therapeutic mechanism].
OBJECTIVE
To explore the therapeutical mechanism of Taozhi Zhipo Granule (TZZPG) on intestinal adhesion.


METHODS
Fed SD male rats of intestinal adhesion model with TZZPG 10, 20 g/kg.d continuously for 12 days.


RESULTS
TZZPG could alleviate the degree and the average length of intestinal adhesion in rats. It also could prolong bleeding time in mice and plasma recuperation time of guinea-pigs, improve the auricular microcirculation in mice, accelerate the removing speed of charcoal powder in mice's intestine and slightly strengthen the contraction of rat intestine in vitro. TZZPG relieved the croton oil topical edema of ear and reduced the capillary permeability of abdominal cavity in mice. TZZPG could enhance the phagocytosis of peritoneal macrophages.


CONCLUSIONS
TZZPG has preventive effect on intestinal adhesion. The action might be due to improve the ischemia in local tissue, strengthen the contraction of intestine and inhibit the inflammation.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D007410:Intestinal Diseases / Q000188:drug therapy*; D017737:Macrophages, Peritoneal / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions