Synthetic oligosaccharides having various functional domains: potent and potentially safe heparin mimetics.
A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets.
D000990:Antithrombin III / Q000037:antagonists & inhibitors; D002240:Carbohydrate Sequence; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000031:analogs & derivatives*; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D013917:Thrombin / Q000037:antagonists & inhibitors