Urinary glycosaminoglycan excretion in urolithiasis.
Urinary glycosaminoglycan (GAG) excretion was measured in children with idiopathic urolithiasis (15 girls and 10 boys; mean (SD) age 6.2 (2.4) years) and in healthy controls (10 girls and 14 boys; mean (SD) age 6.8 (3.8) years). GAG excretion was expressed as a GAG/creatinine (mg/g) ratio and was evaluated using dimethylmethylene blue. In healthy control children, the mean (SD) GAG/creatinine ratio was 31.67 (12.76) and it was similar in girls and boys. The children with idiopathic urolithiasis had significantly lower mean (SD) GAG/creatinine ratios than controls (22.59 (7.35)). Therefore, urinary GAG excretion may be important in the disease process in children with urolithiasis, as it is in adults.
D015415:Biomarkers / Q000652:urine; D002118:Calcium / Q000652:urine; D016022:Case-Control Studies; D002648:Child; D003404:Creatinine / Q000652:urine; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000652:urine; D008297:Male; D010070:Oxalates / Q000652:urine; D010710:Phosphates / Q000652:urine; D014527:Uric Acid / Q000652:urine; D014545:Urinary Calculi / Q000652:urine*