New synthetic heparin mimetics able to inhibit thrombin and factor Xa.
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT III) binding pentasaccharide prolonged at the non-reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin.
D002240:Carbohydrate Sequence; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D013917:Thrombin / Q000037:antagonists & inhibitors*