[Study on HCV infection and the distribution of HCV genotypes in different populations in Shenyang area].
3,902 serum samples in different populations were tested for anti-HCV by ELISA. Among 100 samples of them, genotypes of HCV were detected by PCR with type-specific primers. The results showed: a) anti-HCV positive rates in general populations were 0.42%-1.66%; b) anti-HCV positive rates in the group of post-transfusion hepatitis and sporadic hepatitis (excluding HAV, HBV, EBV, CMV infection), hepatitis B post hepatitis cirrhosis (excluding HBV infection) and primary hepatocarcinoma were significantly higher than the group of patients without liver diseases or the group of patients without transfusion (P < 0.01); c) in HCV genotyping, HCV-II, HCV-III, II/III mixed type were 58%, 27%, 14% respectively. The rate of infection with HCV-III, was 80% in normal population but 91.7% with type II HCV in the group of patients with cirrhosis. These results suggested: (1) patients with different liver diseases were under high risk of HCV infection; (2) type HCV-II was predominant followed by HCV-III as well as II/III mixed in HCV genotype distribution of Shenyang area. Different genotypes of HCV might be related to the severity of hepatitis C.
D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006526:Hepatitis C / Q000453:epidemiology / Q000821:virology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged