Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats.
Adjuvant arthritis is widely used as an experimental model for rheumatoid arthritis and inflammation. It is useful in the evaluation of anti-inflammatory drugs. Lupeol is a naturally occuring triterpene isolated from Crataeva nurvala stem bark, and its ester lupeol linoleate was synthesized. The effects of lupeol and lupeol linoleate on the development of complement in adjuvant arthritis in rats were studied and compared with those of indomethacin. The effect of lupeol linoleate in reducing the foot-pad thickness and complement activity in arthritic rats was even greater than that of unesterified lupeol and indomethacin. Because complement is highly involved in inflammation, the results suggest that the anti-inflammatory activity of triterpenes may be due to their anticomplementary activity.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D003167:Complement Activation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use; D019787:Linoleic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D053978:Pentacyclic Triterpenes; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000627:therapeutic use*; D000094042:Lupanes