[Molecular marker as an indicator in presaging prognosis of human lung adenocarcinoma].
The paper discusses 93 cases of human lung adenocarcinoma in terms of molecular-epidemiology. The relationship between p21 protein and p53 protein and proliferating cell nuclear antigen (PCNA) was analysed by immunohischemical methods. Prognosis by Cox model was used for prosnosis prediction of adenocarcinoma in human lung. Results showed that the prognosis of adenocarcinoma was poor when of p21 protein expression was positive and the relative ratio was 2.08. However, p53 protein expression was not related to the prognosis of adenocarcinoma. The higher the positive rate of PCNA was, the poorer the prognosis of adenocarcinoma oppeared, with a ratio of 3.27.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000401:mortality*; D008297:Male; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis