Intralesional injection of triamcinolone in the treatment of lichen sclerosus.
OBJECTIVE
To assess intralesional vulvar injections of triamcinolone as an alternative to using topical treatment.


METHODS
This was an open trial, in eight patients, of intralesional injection of triamcinolone in patients with symptomatic lichen sclerosus who could not use primary topical treatments. The patients' pretreatment and posttreatment clinical symptoms and gross physical findings were reviewed. In some patients pretreatment and posttreatment biopsies were performed.


RESULTS
There was a decrease in severity scores in the categories of symptoms and physical findings. In four patients who consented to posttreatment biopsy, there was a decrease in severity scores on histopathologic findings.


CONCLUSIONS
Intralesional injection of triamcinolone hexacetonide into sites of vulvar lichen sclerosus seems to be an effective alternative to using topical agents.
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001706:Biopsy; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D018459:Lichen Sclerosus et Atrophicus / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*; D007724:Vulvar Lichen Sclerosus / Q000145:classification / Q000188:drug therapy* / Q000473:pathology