title: Interferon alpha treatment of molluscum contagiosum in immunodeficiency.
abstract: A sister (aged 6 years) and brother (aged 8 years) presented four months apart with severe molluscum contagiosum. Both children demonstrated clinical and laboratory evidence of combined immunodeficiency. The extent of skin involvement by molluscum contagiosum precluded conventional treatment as well as intralesional interferon alpha (IFN alpha). Both subjects responded well to subcutaneous IFN alpha.
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D008976:Molluscum Contagiosum / Q000628:therapy*; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000628:therapy