Effects of Ro 31-8220 on smooth muscle cell proliferation induced by fibrinogen degradation products.
OBJECTIVE
To study the mitogenic activity of fibrin fibrinogen degradation products (FFDP) and the effect of a new selectively potent protein kinase C (PKC) inhibitor Ro 31-8220 (Ro).


METHODS
Rat aortic smooth muscle cells (SMC) proliferation in culture was measured by crystal violet staining assay.


RESULTS
FFDP stimulated the proliferation of SMC during the experimental period of 72 h, Ro 0.01-1 mumol.L-1 inhibited FFDP-induced cell proliferation in a concentration-dependent manner.


CONCLUSIONS
Ro exerted inhibitory effect on cell proliferation induced by FFDP.
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005338:Fibrin Fibrinogen Degradation Products / Q000037:antagonists & inhibitors*; D007211:Indoles / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar