[The effect of different doses of gonadotropins on the quantitative, morphological and cytogenetic characteristics of oocytes from CBA mice].
The effect of gonadotropins (PMSG/HCG) dose on number, quality and cytogenetic characteristics of CBA mouse oocytes was investigated. The oocytes from natural cycle were used as a control. Using of 5 IU dose led to increasing of oocytes number with no differences in their parameters from control ones. Percentage of oocytes of bed quality, with nuclear material degeneration, and parthenogenetically activated oocytes were found to increase under 10 IU and 15 IU dosage.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D009865:Oocytes / Q000166:cytology / Q000187:drug effects*; D010312:Parthenogenesis / Q000187:drug effects; D013480:Superovulation / Q000187:drug effects