title: Bone marrow as a potential source of hepatic oval cells.
abstract: Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells, or oval cells during liver regeneration. Cross-sex or cross-strain bone marrow and whole liver transplantation were used to trace the origin of the repopulating liver cells. Transplanted rats were treated with 2-acetylaminofluorene, to block hepatocyte proliferation, and then hepatic injury, to induce oval cell proliferation. Markers for Y chromosome, dipeptidyl peptidase IV enzyme, and L21-6 antigen were used to identify liver cells of bone marrow origin. From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability.
mesh_terms: D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002454:Cell Differentiation; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000235:genetics; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology; D017403:In Situ Hybridization; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D009687:Nuclear Proteins; D016133:Polymerase Chain Reaction; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D051876:Sex-Determining Region Y Protein; D013234:Stem Cells / Q000166:cytology*; D014157:Transcription Factors; D014998:Y Chromosome