Phenolic compounds from Duchesnea chrysantha and their cytotoxic activities in human cancer cell.
Five phenolic compounds were isolated from 80% aq. acetone extract of Duchesnea chrysantha. Their cytotoxicities were screened by the colorimetric tetrazolium assay (MTT assay). Gallic acid, methyl caffeate, protocatechuic acid and pedunculagin mildly inhibited the survival of PC14 and MKN45 human cancer cell. Brevifolin carboxylic acid showed a strong cytotoxic activity.
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D047348:Hydrolyzable Tannins / Q000302:isolation & purification / Q000494:pharmacology; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured