Graft-like plantar lesion secondary to possible dorsal-to-ventral cutaneous transposition.
We describe a 3-year-old male patient with an unusual congenital lesion on the plantar surface of the left foot that had been asymptomatic until shortly before presentation. Histologic examination of the plaque revealed a thinner keratin layer, increased pigmentation, and a pilosebaceous unit with a visible vellus hair. We tentatively hypothesize from this single case that a disruption in the normal sequence of events of morphogenesis, and particularly in dorsal-to-ventral orientation, may have occurred in this patient.
D002675:Child, Preschool; D005534:Foot Diseases / Q000151:congenital* / Q000473:pathology; D006197:Hair / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D009024:Morphogenesis; D010859:Pigmentation Disorders / Q000151:congenital / Q000473:pathology; D012627:Sebaceous Glands / Q000473:pathology; D012868:Skin Abnormalities / Q000473:pathology*