Dextromethorphan metabolic phenotyping in a Chinese population.
OBJECTIVE
To establish a phenotyping of dextromethorphan (DM) oxidation polymorphism in a native Chinese population.


METHODS
The urine concentrations of DM and its metabolite dextrophan (DX) were assayed by HPLC and metabolic ratios (MR) were calculated in 120 unrelated native Chinese subjects after ingestion of DM 20 mg.


RESULTS
The incidence of poor metabolizers was 0.8% (one in 120 subjects). There were distinct dimodal distributions which divided extensive metabolizers into 43 intermediate metabolizers and 76 very extensive metabolizers. The 0-8 h urinary recoveries of DM and DX were 0.4% +/- s 0.5% and 26% +/- s 13%, respectively. There was no difference in 0-8 h urinary recoveries between male and female subjects.


CONCLUSIONS
DM metabolic phenotyping provides a new information for debrisoquine 4-hydroxylation (CYP2D6) polymorphism in native Chinese.
D000293:Adolescent; D000328:Adult; D044466:Asian People; D002681:China; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003915:Dextromethorphan / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic