Aza-analogue of mevinolin: synthesis of substituted octahydroisoquinoline, the bottom half of aza-analogue of mevinolin.
trans-Ethyl 1,2,3,4a,5,6,8a-octahydro-2-benzyl-4-hydroxy-6-methyl-5- isoquinoline-carboxylate was prepared by intramolecular Diels-Alder reaction as a precursor of newly designed aza-analogue of mevinolin.
D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008968:Molecular Conformation