Synthesis and antiviral activity of 1-[1,5-dialkyl-1H-1,2,4-triazol-3-yl)methyl]thymines.
Cycloaddition of the intermediates 2 with 1-(cyanomethyl)-thymine 3 furnished the 1,2,4-triazolium salts 4, which rearranged spontaneously to the protonated salts 5. Hydrolysis of 5, in situ, afforded the title compounds 6. Compounds 6a-c were screened against HIV-1 (IIIB), HIV-2 (ROD), and human cytomegalovirus (HMCV) and showed poor or no activity, respectively.
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D013941:Thymine / Q000138:chemical synthesis* / Q000494:pharmacology