[Evaluation of loretadine therapy by rhino-manometry in patients with allergic rhinitis].
The authors evaluated the nasal flow and resistance by rhinomanometry in 21 children suffering from ragweed allergy during the season. After this process the loratadine was administered for 1 month. During the therapy the nasal parameters were checked at 2 and 4 weeks, again. The loratadine significantly decreased the nasal resistance in 18 children and improved the nasal airflow in 17 cases. In the second part of the examination 15 ragweed sensitized children were undergone nasal allergen-specific challenge after 40 minutes taken loratadine. The nasal parameters were checked after 30 minutes and 6-8 hours. The statistical analyzes proved that loratadine can prevent and inhibit the early and late-phase of Type I hypersensitivity in contrast of the 12 children who were challenged without loratadine administration. They showed nasal obstruction. Based on the results, loratadine can be considered very effective antihistamine-antiallergenic drug which improves the quality of life of the allergic patients.
D000293:Adolescent; D000367:Age Factors; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D017336:Loratadine / Q000627:therapeutic use*; D008297:Male; D008365:Manometry; D009666:Nose / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D016008:Statistical Distributions