Nitric oxide and thiol groups.
S-Nitroso(sy)lation reactions have recently been appreciated to regulate protein function and mediate 'nitrosative' stress. S-Nitrosothiols (SNOs) have been identified in a variety of tissues, and represent a novel class of signaling molecules which may act independently of homolytic cleavage to NO - and, indeed, in a stereoselective fashion - or be metabolized to other bioactive nitrogen oxides. It is now appreciated that sulfur-NO interactions have critical physiological relevance to mammalian neurotransmission, ion channel function, intracellular signaling and antimicrobial defense. These reactions are promising targets for the development of new medical therapies.
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry; D008623:Mercaptoethanol; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism; D009603:Nitroso Compounds / Q000737:chemistry / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism; D026403:S-Nitrosothiols; D015398:Signal Transduction; D013053:Spectrophotometry; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism; D013455:Sulfur / Q000737:chemistry* / Q000378:metabolism