title: Effects of soy protein diet on digestive lumenal polyamines and colonic cell proliferation in pigs.
abstract: This study was performed to determine whether erythrocyte and digestive lumenal polyamine concentrations are affected by a soy protein diet when compared to a casein diet. We also determined the effects of these diets on colonic cell proliferation. Sixteen pigs received either a 16% soy protein or casein diet for 25 days. The erythrocyte putrescine was higher in pigs fed the soy protein diet. Significant levels of polyamines were observed in the digestive lumen on both diets. Lumenal putrescine and cadaverine were higher in the proximal colon in the casein group. Lumenal spermidine was higher in the caecum and colon in the soy protein group. No significant differences in the ornithine decarboxylase activity nor in the proliferative cell nuclear antigen labelling index were observed in the colonic mucosa regardless of the regimen. These results indicate that the dietary source of protein induces significant changes in lumenal polyamines in the colon. The physiological effects of these changes need to be further investigated.
mesh_terms: D000818:Animals; D002455:Cell Division; D003106:Colon / Q000737:chemistry / Q000166:cytology* / Q000201:enzymology; D004044:Dietary Proteins / Q000494:pharmacology*; D004064:Digestive System / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D007413:Intestinal Mucosa / Q000737:chemistry / Q000201:enzymology; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011073:Polyamines / Q000097:blood / Q000378:metabolism*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011700:Putrescine / Q000097:blood / Q000378:metabolism; D030262:Soybean Proteins / Q000494:pharmacology*; D013095:Spermidine / Q000097:blood / Q000378:metabolism; D013096:Spermine / Q000097:blood / Q000378:metabolism; D013552:Swine