Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.
A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.
D002460:Cell Line; D006801:Humans; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000493:pharmacokinetics*