Synthesis of (2S,3R)-beta-methyltyrosine catalyzed by tyrosine phenol-lyase.
A one-step enzymatic synthesis of the conformationally restrained tyrosine analog (2S,3R)-beta-methyltyrosine is reported. This synthesis extends the preparative chemistry associated with tyrosine phenol-lyase. This beta-methyltyrosine derivative was shown to be an efficient protein tyrosine kinase substrate, suggesting that conformational restraint may ultimately be used to enhance tyrosine kinase recognition of substrates.
D002384:Catalysis; D008781:Methyltyrosines / Q000138:chemical synthesis*; D014447:Tyrosine Phenol-Lyase / Q000737:chemistry*