title: Synthesis of Mannich bases of antineoplaston A10 and their antitumor activity.
abstract: Some Mannich bases of Antineoplaston A10 which is antitumor agent under clinical investigation were synthesized and tested for cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D044482:Benzeneacetamides; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008352:Mannich Bases / Q000138:chemical synthesis*; D010881:Piperidones / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured