Synthesis and antibacterial activity of new cephalosporins with lactonyloxyimino moiety.
A series of 7-¿2-(2-aminothiazol-4-yl)-2-Z-(gamma-lacton-3-yl)oxyimin oacetamido¿ cephalosporins with various substituents at the 3-position in cephem nucleus were synthesized and evaluated microbiologically. The tested compounds showed potent activities but were somewhat less active than cefotaxime or cefixime against a wide variety of Gram-positive and Gram-negative bacteria.
D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D015169:Colony Count, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007097:Imines / Q000138:chemical synthesis* / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology