[Renal crisis in systemic sclerosis].
Systemic sclerosis is a rare connective tissue disorder, potentially affecting several internal organs. Renal disease is seen in 10-40% of the cases, while autopsy studies have shown interstitial renal changes in as many as 80%. Renal involvement is clinically divided into two separate forms; chronic and acute nephritis. Acute nephritis in a patient suffering from systemic sclerosis is termed renal chrisis, and is associated with high morbidity and mortality. Renal crisis in systemic sclerosis is discussed based on a case report and a review of the literature. Treatment with ACE-inhibitors has dramatically improved the prognosis of this complication. Careful surveillance of patients at risk, especially patients with the diffuse type of systemic sclerosis and showing antibodies against RNA-polymerase, as well as early treatment is considered important for the outcome.
D058186:Acute Kidney Injury / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology / Q000473:pathology