Convergent peptide libraries, or mixotopes, to elicit or to identify specific immune responses.
Many recent studies have demonstrated the flexibility of epitope recognition by the immune system. This can be explored using a particular type of combinatorial peptide library, termed as 'convergent', consisting essentially of closely related molecular species; from this a fuzzy set can be constructed, which comprises several variants of a peptide that would act in synchrony to represent a model antigen and its recognition by the immune system.
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000276:immunology*; D000939:Epitopes; D006801:Humans; D008969:Molecular Sequence Data; D019151:Peptide Library; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*