Intracytoplasmic sperm injection pregnancy with trisomy 20p and monosomy 22q in a newborn resulting from a balanced paternal translocation.
In infertile men who carry a balanced reciprocal translocation, intracytoplasmic sperm injection (ICSI) may induce a pregnancy with an abnormal karyotype. This report describes a previously unreported paternal reciprocal translocation leading to a chromosomally unbalanced ICSI pregnancy. The triplet pregnancy resulted in 1 normal girl, 1 physically normal boy with the same balanced paternal translocation, and a severely malformed boy with trisomy 20p and monosomy 22q who died in the neonatal period.
D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009006:Monosomy / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014178:Translocation, Genetic / Q000235:genetics*; D014310:Triplets; D014314:Trisomy / Q000235:genetics*