Resolution of recalcitrant hand warts in an HIV-infected patient treated with potent antiretroviral therapy.
Human papilloma virus (HPV)-related cutaneous manifestations occur with increased frequency and severity among HIV-infected persons. In this report, we describe an HIV-infected man with persistent, severe cutaneous hand warts that did not respond to multiple therapies, including liquid nitrogen cryotherapy, topical dinitrochlorobenzene, topical podophyllin, and intralesional interferon-alfa injections. Approximately 1 year after starting a potent protease inhibitor-containing antiretroviral regimen, the patient's recalcitrant cutaneous warts markedly diminished in size, even though the patient did not receive any specific therapy for the warts after starting aggressive antiretroviral therapy. The patient continued on a potent protease inhibitor-containing antiretroviral regimen and, approximately 2 years later, the warts completely resolved. Our patient's dramatic clinical improvement of cutaneous HPV infection that followed protease inhibitor-containing antiretroviral therapy provides a clear-cut example that protease inhibitor-containing combination antiretroviral therapy can produce significant clinical benefit.
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use; D003452:Cryosurgery; D004137:Dinitrochlorobenzene / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006229:Hand Dermatoses / Q000188:drug therapy / Q000601:surgery / Q000628:therapy* / Q000821:virology; D006801:Humans; D019469:Indinavir / Q000627:therapeutic use*; D016898:Interferon-alpha / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000601:surgery / Q000628:therapy; D011033:Podophyllin / Q000627:therapeutic use; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000601:surgery / Q000628:therapy; D014860:Warts / Q000188:drug therapy / Q000601:surgery / Q000628:therapy* / Q000821:virology