[Electron microscopic observation on cysticercus cellulosae treated with mienangling in vitro].
OBJECTIVE
To observe the effect of Mienangling (MNL) in treating cysticercus cellulosae in vitro.


METHODS
The changes of cysticercus cellulosae treated in vitro with the MNL extracts, praziquantel (PQT) and albendazole (ALB) were studied under the transmission and scanning electron microscopes.


RESULTS
Under the scanning electron microscope, the authors can see that all of the cysticercus's scoleces did not grow in the MNL and PQT groups, cyst walls shrivelled, tegument's ectoplasts were damaged, microtriches's ultrastructures were not clear or exfoliated, some corpuscular matter densely was distributed in the surface; 46.7% of cysticercus cellulosaes in the ALB group had been excystated, the rostellar hooks of rostella developed normally, four sucker's surface wrer hollow, the necks were eroded, and grooves of sonite disappeared. Under the transmission electron microscope, we can see that the tegument, basement membrane, muscular layer and parenchyma in the groups of MNL and PQT were all clearly damaged, but the harmful effect of MNL to parenchyma's nerve cords is more serious than the PQT. The damage of all layers of the cysticercus cellulosae in the ALB group is smaller in degree than the MNL and the PQT.


CONCLUSIONS
The MNL has marked damaging effect to cysticercus cellulosae.
D015766:Albendazole / Q000494:pharmacology; D000818:Animals; D000923:Anticestodal Agents / Q000494:pharmacology*; D003552:Cysticercus / Q000187:drug effects / Q000648:ultrastructure*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011223:Praziquantel / Q000494:pharmacology