title: Basal ganglia germinoma with progressive cerebral hemiatrophy.
abstract: The authors describe a 7-year-old Chinese-American female with a germinoma of the basal ganglia who presented with progressive hemiparesis and cerebral hemiatrophy. The additional finding of markedly elevated antiphospholipid antibodies suggests the possibility of an autoimmune pathogenesis for the progressive cerebral atrophy, as well as the later development of cognitive decline, tics, and obsessive-compulsive behaviors.
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000032:analysis; D001284:Atrophy / Q000209:etiology; D001480:Basal Ganglia Diseases / Q000175:diagnosis / Q000209:etiology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000532:radiotherapy; D002648:Child; D005260:Female; D018237:Germinoma / Q000150:complications / Q000175:diagnosis* / Q000532:radiotherapy; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D011878:Radiotherapy / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome