Nicorandil-induced peripheral vasodilatation during cardiopulmonary bypass.
Nicorandil is an antianginal agent with actions at epicardial coronary arteries and arterioles, systemic arterioles, and veins. We report our experience with 7 patients taking oral Nicorandil who had severe vasodilation and hypotension requiring significant vasoconstrictor support after cardiopulmonary bypass. Although the mechanism for this phenomenon remains unknown Nicorandil might be interacting with other factors present during cardiopulmonary bypass, as it has relatively mild hemodynamic effects outside this situation.
D000284:Administration, Oral; D002315:Cardiopulmonary Bypass; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D020108:Nicorandil / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*