title: Plasmodium chabaudi chabaudi: effect of low parasitemias on immunity in CB6F1 mice.
abstract: We examined the effect that low parasitemias have on the immune response of CB6F1 mice infected with Plasmodium chabaudi chabaudi AS. Ascending parasitemias were stopped by chloroquine treatment when they were between 1.6 and 9.4%. Mice that suffered low parasitemias developed good immunity to homologous reinfection but, contrary to what happened in mice that suffered full parasitemias, they did not develop immunity to heterologous reinfection with Plasmodium yoelii 17XL. Total IgG antiparasite antibody responses were similar in mice that suffered low or full parasitemia, both in primary infection and after reinfection. At the level of isotypes, IgM, IgG1, IgG2b, and IgG3 responses were similar in mice that suffered low or full parasitemias, but after reinfection, mice that suffered low parasitemias responded with higher levels of IgG2a than mice that suffered full parasitemias. Mice that suffered low parasitemias did not have splenomegaly but their immunity to homologous reinfection was diminished after splenectomy in a manner similar to that of splenectomized mice that suffered full parasitemia. CB6F1 mice can develop homologous immunity even if exposed to low parasitemias but cannot develop heterologous immunity unless exposed to high parasite loads.
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D008288:Malaria / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy / Q000276:immunology*; D016788:Plasmodium chabaudi / Q000276:immunology*; D013156:Splenectomy