Outcome of mother to infant acquired GBV-C/HGV infection.
Twelve children born to hepatitis C virus antibody GBV-C/HGV RNA positive mothers who acquired GBV-C/HGV infection by the vertical or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases who acquired GBV-C/HGV alone had normal alanine amino transferase activities. Long lasting evidence of hepatocellular injury was detected only in children with GBV-C/HGV and hepatitis C virus and HIV coinfection.
D018067:Flaviviridae / Q000235:genetics; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000473:pathology / Q000635:transmission; D006526:Hepatitis C / Q000150:complications / Q000473:pathology / Q000635:transmission; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000473:pathology / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000473:pathology; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction