[Studies on effects of yttrium chloride and praseodymium chloride on frequency of micronucleus in human blood lymphocytes].
OBJECTIVE
To explore genotoxicity of rare-earth elements, yttrium and praseodymium.


METHODS
Effects of yttrium chloride and praseodymium chloride on human lymphocytes cultured in vitro were studied by micronucleus test.


RESULTS
Frequency of micronucleus in human blood lymphocytes increased significantly by treatment with yttrium chloride and praseodymium chloride, and it increased with the concentration of the both agents, to a certain range.


CONCLUSIONS
It suggests that rare-earth elements yttrium and praseodymium have certain genotoxicity.
D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D015162:Micronucleus Tests; D011221:Praseodymium / Q000633:toxicity*; D015019:Yttrium / Q000633:toxicity*