[Effect of superoxide dismutase on membrane fluidity and functions of lymphocytes in traumatized mice].
Effect of superoxide dismutase (SOD) on membrane fluidity and functions of lymphocytes in traumatized mice was studied. The results showed that in vivo administration of SOD (10,000 U/kg.d, from 0 to 3 days posttrauma) could significantly decrease malondialdehyde (MDA) contents in serum, lymphatic tissues from spleen, thymus, mesenteric lymph nodes and T cells plasmalemma, mitochondria, microsome, restore decreased T lymphocytes and T cells in traumatized mice, elevate membrane fluidity of lymphocytes transformation (TLT), reduce interleukin 2 (IL-2) production, supprssed IL-2 receptor (IL-2R) expression and depress IL-2 mediated lymphocyte proliferation response (IL 2MLPR) after trauma in various degress. It is suggested that SOD may protect lymphocytes post trauma from damage of oxygen free radical, and elevate lymphocytes functions.
D000818:Animals; D002462:Cell Membrane; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006614:Hindlimb / Q000293:injuries*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*; D014949:Wounds, Nonpenetrating / Q000276:immunology