Effect of sodium taurodihydrofusidate on nasal drug delivery: differences in its concentration and penetrant molecular weight.
The effect of sodium taurodihydrofusidate (STDHF) on drug permeation across nasal mucosa was studied in vitro using Ussing type diffusion chamber. Disodium cromoglicate (DSCG, M.W. 512.3) and fluorescein isothiocyanate-dextran (FD) of different molecular weights (M.W. 4400-71200) were used as model drugs. Permeation profiles of DSCG and FDs showed a typical pseudo steady-state curve with short lag time. The permeability coefficient of FD (M.W. 9400) sigmodially increased with increasing STDHF concentration. It also enhanced the DSCG permeation. Interestingly the enhancement efficacy was independent of molecular weight of penetrants.
D000277:Adjuvants, Pharmaceutic; D000281:Administration, Intranasal; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics; D004205:Cromolyn Sodium / Q000493:pharmacokinetics; D003911:Dextrans / Q000737:chemistry / Q000493:pharmacokinetics; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D005672:Fusidic Acid / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D008297:Male; D008970:Molecular Weight; D009297:Nasal Mucosa / Q000378:metabolism*; D011817:Rabbits