Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
D000818:Animals; D051546:Cyclooxygenase 2; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000187:drug effects*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects*; D051381:Rats; D013450:Sulfones / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis*