title: [Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker].
abstract: 59 patients with mild and moderate essential hypertension have received a course treatment with beta-adrenoblocker proxodolol. The latter was studied for a hypotensive action and cardiohemodynamic effects as regards baseline type of circulation and pacing regimen. Proxodolol hypotensive action in hyperkinetic circulation is attributed primarily to a fall in the ejection (beta-adrenoblock), in hypo- and eukinetic circulation type--to reduction in cardiac postload (alpha-adrenoblock). In isolated ventricular stimulation proxodolol cardiodepressive effect was more pronounced than in atrial stimulation. An overall hypotensive effect of proxodolol in mild arterial hypertension made up 77.2%, in moderate--66.5%.
authors.forename: B G
authors.initials: BG
authors.lastname: Iskenderov
authors.forename: I P
authors.initials: IP
authors.lastname: Tatarchenko
authors.forename: V A
authors.initials: VA
authors.lastname: Shevyrev
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010069:Oxadiazoles / Q000627:therapeutic use*; D010138:Pacemaker, Artificial; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D010069:Oxadiazoles; C088649:proxodolol