Antibodies to cardiolipin and beta2-glycoprotein-1 in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Anticardiolipin and anti-beta2GP1 antibodies were measured in 50 patients with HTLV-1-associated Myelopathy-Tropical Spastic Paraparesis (HAM-TSP) and the results were compared with those obtained for 34 HTLV-1-positive and 35 HTLV-1-negative controls, as well as 128 SLE patients. aCL but not anti-beta2GP1 was associated with HTLV-I infection. aCL was more prevalent than anti-beta2GP1 (32% vs. 8%) and was not associated with anti-beta2GP1 in HAM-TSP. IgA was the dominant isotype of aCL and anti-beta2GP1. The data suggest that tin HAM-TSP, IgA aCL are frequent and are associated with HTLV-1 infection.
Faghiri
Z
Z
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112-2822, USA.
Wilson
W A
WA
Taheri
F
F
Barton
E N
EN
Morgan
O S
OS
Gharavi
A E
AE
D017153:Antibodies, Anticardiolipin / Q000097:blood*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016022:Case-Control Studies; D006023:Glycoproteins / Q000276:immunology*; D015490:HTLV-I Infections / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007132:Immunoglobulin Isotypes / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D007070:Immunoglobulin A; D007132:Immunoglobulin Isotypes; D053482:beta 2-Glycoprotein I