UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.
Keppler
O T
OT
Applied Tumor Virology Program, Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Hinderlich
S
S
Langner
J
J
Schwartz-Albiez
R
R
Reutter
W
W
Pawlita
M
M
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D002238:Carbohydrate Epimerases / Q000235:genetics / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003470:Culture Media; D029968:Escherichia coli Proteins; D006001:Glycoconjugates / Q000378:metabolism*; D018922:HL-60 Cells; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D006801:Humans; D037102:Lectins / Q000378:metabolism; D016256:Lewis X Antigen / Q000096:biosynthesis; D018950:Lipopolysaccharide Receptors / Q000096:biosynthesis; D009844:Oligosaccharides / Q000096:biosynthesis; D051381:Rats; D051918:Sialic Acid Binding Ig-like Lectin 2; D012794:Sialic Acids / Q000096:biosynthesis*; D000080506:Sialyl Lewis X Antigen; D014158:Transcription, Genetic; D014162:Transfection; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D003470:Culture Media; D029968:Escherichia coli Proteins; D006001:Glycoconjugates; D015395:Histocompatibility Antigens Class I; D037102:Lectins; D016256:Lewis X Antigen; D018950:Lipopolysaccharide Receptors; D009844:Oligosaccharides; D051918:Sialic Acid Binding Ig-like Lectin 2; D012794:Sialic Acids; D000080506:Sialyl Lewis X Antigen; D002238:Carbohydrate Epimerases; C100033:UDP acetylglucosamine-2-epimerase; C083982:wecB protein, E coli