title: [Mechanisms of selective vulnerability of cholinergic neurons to neurotoxic stimuli].
abstract: Preferential loss of cholinergic neurons in course of several encephalopathies may result from the fact that they utilize acetyl-CoA not only for energy production, but also for acetylcholine synthesis. Changes in activities of acetyl-CoA metabolizing enzymes and shifts in acetyl-CoA compartmentalization, found in different animal models of brain pathologies and in human post mortem brain, are discussed in therms of their impact on cholinergic system integrity.
authors.affiliation: Katedra i Zakład Biochemii Klinicznej Akademii Medycznej w Gdańsku.
authors.forename: A
authors.initials: A
authors.lastname: Szutowicz
authors.forename: M
authors.initials: M
authors.lastname: Tomaszewicz
authors.forename: A
authors.initials: A
authors.lastname: Jankowska
authors.forename: B
authors.initials: B
authors.lastname: Madziar
authors.forename: H
authors.initials: H
authors.lastname: Bielarczyk
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000109:Acetylcholine / Q000096:biosynthesis; D000535:Aluminum / Q000633:toxicity; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D003929:Diabetic Neuropathies / Q000378:metabolism; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000105:Acetyl Coenzyme A; D000535:Aluminum; D000109:Acetylcholine