title: I-type lectins in the nervous system.
abstract: The number of animal lectins, basically defined upon their interaction with specific carbohydrate structures, is growing considerably during the last few years. Among these proteins the recently identified subfamily of I-type lectins consists of mainly transmembranous glycoproteins belonging to the immunoglobulin superfamily. Most of the I-type lectins participate in cell adhesion events, as are the different sialoadhesins recognizing sialylated glycan structures, which represent the best characterized subgroup. I-type lectins are abundant in the nervous system and have been implicated in a number of morphogenetic processes as fundamental as axon growth, myelin formation and growth factor signaling. In the present review, we summarize the structural and functional properties of I-type lectins expressed in neural tissues with a main focus on the sialoadhesin myelin-associated glycoprotein, the neural cell adhesion molecule and the fibroblast growth factor receptors.
authors.affiliation: Department of Biochemistry, Institute for Animal Anatomy and Physiology, University of Bonn, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Probstmeier
authors.forename: P
authors.initials: P
authors.lastname: Pesheva
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D018993:Myelin P0 Protein / Q000737:chemistry / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry / Q000378:metabolism; D009420:Nervous System / Q000166:cytology* / Q000378:metabolism; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry / Q000378:metabolism; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism; D063267:Sialic Acid Binding Ig-like Lectin 1; D015398:Signal Transduction
chemical_list: D037102:Lectins; D008562:Membrane Glycoproteins; D018993:Myelin P0 Protein; D018992:Myelin-Associated Glycoprotein; D019006:Neural Cell Adhesion Molecules; D011509:Proteoglycans; D017468:Receptors, Fibroblast Growth Factor; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1