[Induction of apoptosis by receptors for factors from the TNF family].
Mechanisms leading to induction of apoptosis by TNF family receptors involve intracellular activation of cysteinyl-aspartate-specific proteases (caspases). Caspase activation requires engagement of adaptor proteins. It is plausible, that caspase activation is sufficient for cell death in course of receptor-dependent induction of apoptosis. However, there are some data that programmed cell death involves also generation of ceramides, arachidonic acid metabolism, or MAP kinase (SAPK/JNK) activation. On the other hand, TNF receptor family triggers some protective, anti-apoptotic mechanisms, i.e. protein kinase C (PKC) and NF-kappa B. The outcome of induction of apoptosis by TNF receptor family depends on the cell type, its physiological condition and influence of environmental factors.
Grzela
T
T
Pracownia Biologii Molekularnej Komórki Zakładu Histologii i Embriologii Instytutu, Biostruktury Akademii Medycznej w Warszawie.
Ołdak
M
M
Jóźwiak
J
J
Malejczyk
J
J
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016718:Arachidonic Acid / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D002518:Ceramides / Q000378:metabolism; D006801:Humans; D010741:Phospholipases A / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D002518:Ceramides; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D016718:Arachidonic Acid; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D010741:Phospholipases A; D020169:Caspases