title: Comparison of two concentrations of amphotericin B bladder irrigation in the treatment of funguria in patients with indwelling urinary catheters.
abstract: The efficacy of amphotericin B bladder irrigation at two concentrations was studied. Patients with funguria (> or =15,000 colony-forming units of yeast per milliliter of urine), an indwelling urinary catheter, and a physician order for amphotericin B continuous bladder irrigation were randomly assigned to receive 10 or 50 mg of amphotericin B per liter of sterile water as a continuous irrigation for 72 hours at the rate of 42 mL/hr. Before the bladder irrigation began, the indwelling catheter was changed to a three-way catheter. Repeat urine cultures were performed 24 hours after the irrigation was discontinued. A total of 28 patients were enrolled from November 1993 to May 1995. The rate of eradication of the infection was 100% in the 50-mg/L group and 67% in the 10-mg/ L group. Subject enrollment was stopped prematurely because all the treatment failures occurred in the 10-mg/L group. Dose was the only variable significantly associated with outcome. Bladder irrigation with amphotericin B was more effective when the drug concentration was 50 mg/L rather than 10 mg/L.
authors.affiliation: Cancer Pain Program, Cancer Center, Akron General Medical Center, OH 44307, USA. snesbit@agmc.org
authors.forename: S A
authors.initials: SA
authors.lastname: Nesbit
authors.forename: L E
authors.initials: LE
authors.lastname: Katz
authors.forename: B W
authors.initials: BW
authors.lastname: McClain
authors.forename: D P
authors.initials: DP
authors.lastname: Murphy
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D007507:Therapeutic Irrigation; D001745:Urinary Bladder Diseases / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B