Cutting edge: anti-CD1 monoclonal antibody treatment reverses the production patterns of TGF-beta 2 and Th1 cytokines and ameliorates listeriosis in mice.
Protection against intracellular bacteria by T cells is regulated by Ag-presenting molecules, which comprise classical MHC class I molecules, MHC class II molecules, and nonclassical MHC class Ib molecules. The role of CD1 molecules, which are structurally similar to classical MHC class I gene products, but less polymorphic, is not understood so far. We show that CD1 surface expression increased on APC in Listeria-infected mice. The in vivo treatment with anti-CD1 mAb reduced TGF-beta 2 levels and concomitantly increased secretion of the proinflammatory cytokine TNF, the Th1 cell promoting cytokine IL-12, and the Th1 cell cytokine IFN-gamma at the onset of listerial infection. These findings point to a regulatory role of CD1-reactive cells in the immune response against listeriosis.
Szalay
G
G
Max Planck Institute for Infection Biology, Berlin, Germany.
Ladel
C H
CH
Blum
C
C
Brossay
L
L
Kronenberg
M
M
Kaufmann
S H
SH
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018949:Antigens, CD1 / Q000096:biosynthesis / Q000276:immunology*; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000378:metabolism; D005260:Female; D008088:Listeriosis / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018417:Th1 Cells / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D000911:Antibodies, Monoclonal; D018949:Antigens, CD1; D016207:Cytokines; D016212:Transforming Growth Factor beta