title: A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.
abstract: A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10' '-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.
authors.affiliation: College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lim
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: N D
authors.initials: ND
authors.lastname: Kim
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D004279:DNA, Viral / Q000378:metabolism; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013539:Simian virus 40 / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013402:Sugar Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059004:Topoisomerase I Inhibitors
chemical_list: C120215:1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10''-methylhexadecyl)glycerol; D004279:DNA, Viral; D019384:Nucleic Acid Synthesis Inhibitors; D013402:Sugar Alcohols; D059004:Topoisomerase I Inhibitors; D005990:Glycerol