[The role of MAP kinases and inducible transcription factors in the regulation of cell death and survival].
Cell growth and survival are constantly promoted and modulated by a variety of extracellular stimuli. Modules of sequentially activating protein kinases serve as important routes for the intracellular transmission of signals from diverse stimuli to nucleus. The Raf signaling involving Mitogen-Activated Protein (MAP) kinases is a key element of mitogenic stimulation. The c-Jun N-terminal kinases (JNKs) are activated in cells in response to cytokines, stress or proapoptotic stimuli, indicating that this signaling pathway may contribute to inflammatory and cell death phenomena. Cross-talk between different MAP kinase signaling pathways determines cellular responses in stress, apoptosis and normal physiological processes.
Kamińska
B
B
Pracownia Regulacji Transkrypcji Zakładu Biochemii Komórki, Instytutu Biologii Doświadczalnej PAN, Warszawie.
Pyrzyńska
B
B
D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D015870:Gene Expression; D006133:Growth Substances / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
D006133:Growth Substances; D014157:Transcription Factors; D017871:Calcium-Calmodulin-Dependent Protein Kinases