Primary infection of human herpesvirus 6 in children with vertical infection of human immunodeficiency virus type 1.
The role of human herpesvirus 6 (HHV-6) infection in 227 children born to human immunodeficiency virus (HIV)-seropositive mothers was investigated. Of 41 HIV-uninfected infants, 3 (7%) were positive for HHV-6 DNA in the first month of life, suggesting possible intrauterine infection. The cumulative infection rates of HHV-6 at 6 and 12 months of age were significantly lower in HIV-infected children (11% and 33%, respectively) than in uninfected children (28% and 78%, respectively; P<.001). There was an association between high CD4+ cell numbers (>15%) before HHV-6 infection and high HHV-6 infection rate. Twenty-two infants with HIV classed as Centers for Disease Control and Prevention stages N1 or N2 were studied for an association of HHV-6 infection with progression of HIV disease. Ten of the infants had HHV-6, and 12 did not. In 5 of the infants without HHV-6 (42%), HIV disease had not progressed by 1 year of age; however, HIV disease had progressed in all 10 children with HHV-6 infection. These results suggest an association of HHV-6 infection and progression of HIV disease in the study children with vertical HIV-1 infection (P<.05).
Kositanont
U
U
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. gruks@mahidol.ac.th
Wasi
C
C
Wanprapar
N
N
Bowonkiratikachorn
P
P
Chokephaibulkit
K
K
Chearskul
S
S
Chimabutra
K
K
Sutthent
R
R
Foongladda
S
S
Inagi
R
R
Kurata
T
T
Yamanishi
K
K
D018791:CD4 Lymphocyte Count; D004279:DNA, Viral / Q000097:blood; D006679:HIV Seropositivity / Q000150:complications / Q000453:epidemiology* / Q000635:transmission; D015497:HIV-1; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology*; D015654:Herpesvirus 6, Human; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D015995:Prevalence; D013785:Thailand / Q000453:epidemiology
D004279:DNA, Viral