The protective effect of lipoxygenase inhibitor FLM 5011 on mitochondria ultrastructure of ischemic and reperfused cardiomyocytes.
Lipoxygenase inhibitor FLM 5011 was used in experimental ischemia and reperfusion with dogs to investigate its ultrastructure-preserving effects on the mitochondria of myocardium. Ischemic and non-ischemic areas of the heart were ultrastructural-morphometric analysed, which revealed that FLM 5011 was able to diminish ischemic damage especially of mitochondria. The protective effects on mitochondria consisted mainly in reduction of defective intramitochondrial areas and in excellent protection of the structural integrity of cristae and matrix. The injury of mitochondria by ischemia/reperfusion in unprotected condition was partly more pronounced in the non-ischemic than in the ischemic area of the hearts probably caused by compensatory overload of the residual myocardium.
Fitzl
G
G
Institute of Anatomy, University of Leipzig, Germany.
Winkler
D
D
Wassilev
G
G
Welt
K
K
D000818:Animals; D003627:Data Interpretation, Statistical; D004285:Dogs; D005260:Female; D007850:Lauric Acids; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000166:cytology / Q000473:pathology / Q000648:ultrastructure; D010091:Oximes; D013908:Thoracotomy
D007850:Lauric Acids; D016859:Lipoxygenase Inhibitors; D010091:Oximes; C059535:FLM 5011