Estimation of pulmonary deposition of aerosol using gamma scintigraphy.
Following delivery of technetium 99m-labeled aerosols through a ventilator circuit, the amount of radioactivity in the lungs of 58 ventilated rabbits was estimated first by gamma scintigraphy via gamma camera and later by direct counting of the excised lungs (n = 116 specimens) with a gamma counter. The in situ radioactivity measured via scintigraphy was closely correlated with the gamma counter ex vivo tissue counts of the radioactivity (R2 = 0.997, P < 0.001). Overall, gamma scintigraphy gave slightly lower values of activity than the tissue counts from the gamma counter, but the limits of agreement between the two measurements were narrow enough for us to consider that the tissue and scintigraphy methods were in agreement. We conclude that gamma scintigraphy provides a convenient and noninvasive means for the accurate estimation of aerosol deposition in the lungs of small animals and possibly in small infants.
Fok
T F
TF
Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
al-Essa
M
M
Kirpalani
H
H
Monkman
S
S
Bowen
B
B
Coates
G
G
Dolovich
M
M
D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics; D000818:Animals; D001688:Biological Products; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D004338:Drug Combinations; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000493:pharmacokinetics; D015902:Gamma Cameras; D008168:Lung / Q000000981:diagnostic imaging*; D010767:Phosphorylcholine; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000493:pharmacokinetics; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012588:Scintillation Counting; D013670:Sodium Pertechnetate Tc 99m; D013668:Technetium Tc 99m Aggregated Albumin
D000336:Aerosols; D001688:Biological Products; D001993:Bronchodilator Agents; D004338:Drug Combinations; D005233:Fatty Alcohols; D011663:Pulmonary Surfactants; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D010767:Phosphorylcholine; D011092:Polyethylene Glycols; C047049:dipalmitoylphosphatidylcholine, hexadecanol, tyloxapol drug combination; D013670:Sodium Pertechnetate Tc 99m; D000420:Albuterol; C072197:beractant