Spinal cord compression in beta-thalassemia: follow-up after radiotherapy.
BACKGROUND
Spinal cord compression due to extramedullary hematopoiesis is a well-described but rare syndrome encountered in several clinical hematologic disorders, including beta-thalassemia.


METHODS
We report the case of a patient with intermediate beta-thalassemia and crural paraparesis due to spinal cord compression by a paravertebral extramedullary mass. She was successfully treated with low-dose radiotherapy and transfusions. After splenectomy, she was regularly followed up for over four years without transfusion or recurrence of spinal cord compression.


CONCLUSIONS
Extramedullary hematopoiesis should be investigated in patients with hematologic disorders and spinal cord symptoms. The rapid recognition and treatment with radiotherapy can dramatically alleviate symptoms.
da Fonseca
S F
SF
Figueiredo
M S
MS
Cançado
R D
RD
Nakandakare
F
F
Segreto
R
R
Kerbauy
J
J
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006411:Hematopoiesis, Extramedullary / Q000528:radiation effects*; D006801:Humans; D013117:Spinal Cord Compression / Q000209:etiology* / Q000532:radiotherapy*; D017086:beta-Thalassemia / Q000150:complications*