[Disturbance of signalling pathways for apoptosis in thymic lymphomas from TCR transgenic mice].
The abrogation of apoptosis during development of thymocytes could contribute to the lymphomagenesis of immature thymocytes which otherwise would be deleted. In agreement with this possibility it was found that cells of thymic lymphomas from TCR anty H-Y transgenic mice were resistant to TCR mediated apoptosis. Molecular mechanism responsible for resistance to TCR/Nur77-mediated apoptosis in these lymphomas is discussed.
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Laboratorium Immunologii Komórkowej, Instytutu Immunologii i Terapii Doświadczalnej PAN, Wrocławiu.
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D008223:Lymphoma / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology*; D013953:Thymus Neoplasms / Q000503:physiopathology*
D011948:Receptors, Antigen, T-Cell