Effect of azithromycin plus rifampin versus that of azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis.
Azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against Chlamydia pneumoniae AR-39. The combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of C. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis.
Wolf
K
K
Department of Clinical Research, Inselspital, University of Bern, Bern, Switzerland.
Malinverni
R
R
D000818:Animals; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004269:DNA, Bacterial / Q000032:analysis; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology*; D008297:Male; D051379:Mice; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use*
D004269:DNA, Bacterial; D017963:Azithromycin; D012293:Rifampin