title: [Obstetric problems followed by stroke].
abstract: Obstetrical problems sometimes portend manifestations of atherosclerosis, as illustrated by two case reports. The first patient had the combination of hyperhomocysteinaemia due to chronic vitamin deficiencies in the diet, and smoking. The second was also a smoker and had a genetically determined mild hyperhomocysteinaemia, aggravated by chronic vitamin deficiencies resulting from poor dietary habits; she also had an increased folic acid requirement because of use of anti-epileptic drugs in combination with a familial predisposition for premature atherosclerotic manifestations. The first patient had four pregnancies, two of which ended in intrauterine foetal death due to placental infarction, and one in the birth of a dysmature boy. The second patient's four pregnancies ended twice in abortion and twice in the birth of a dysmature child; in one of the latter cases placental infarction was observed. Both women subsequently suffered cerebrovascular accidents while in addition, older cerebral infarctions were found to be present. Women with recurrent abortion, pre-eclampsia, placental infarction, placental detachment and foetal growth retardation should be examined, even if other risk factors are also present, for (mild) hyperhomocysteinaemia, and treated for it with vitamin suppletion (folic acid, vitamins B6 and B12), even although admittedly more research is necessary to make certain that such treatment has a preventive effect on the manifestations of this disorder.
authors.affiliation: Rijksuniversiteit, faculteit der Medische Wetenschappen, Groningen.
authors.forename: M F
authors.initials: MF
authors.lastname: Lubbers
authors.forename: J G
authors.initials: JG
authors.lastname: Aarnoudse
authors.forename: J J
authors.initials: JJ
authors.lastname: van Doormaal
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology; D000328:Adult; D001161:Arteriosclerosis / Q000150:complications / Q000235:genetics; D002544:Cerebral Infarction / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D005313:Fetal Death; D005492:Folic Acid / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000175:diagnosis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D009748:Nutrition Disorders / Q000150:complications / Q000175:diagnosis*; D010927:Placental Insufficiency / Q000209:etiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000209:etiology*; D011736:Pyridoxine / Q000627:therapeutic use; D012907:Smoking; D020246:Venous Thrombosis / Q000209:etiology; D026681:Vitamin B 6 Deficiency / Q000175:diagnosis
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D008715:Methionine; D011736:Pyridoxine