title: [Ventilator-associated pneumonia; controversies with respect to diagnosis, pathogenesis, therapy and prevention].
abstract: Ventilator-associated pneumonia (VAP) is the most frequent nosocomial infection among intensive care patients; it is associated with increased morbidity and mortality. VAP is always preceded by colonization of the upper respiratory tract with potentially pathogenic micro-organisms. Oropharyngeal colonization is pivotal in the pathogenesis of VAP, while gastric and intestinal colonization appear to be less important than generally believed. The diagnosis is difficult and usually relies on a combination of clinical, microbiological and radiographic criteria. This combination of criteria may have a high sensitivity for VAP, but specificity is low. As a result, many patients receive antibiotics unnecessarily. Bronchoscopic sampling of lower airways can increase specificity, but whether these relatively expensive techniques are cost-effective remains to be established. The best antibiotic therapy for VAP is unknown. General infection control measures remain the cornerstone of infection prevention in each intensive care unit (ICU). Selective digestive decontamination (SDD) was associated with a reduction in the incidence of VAP, but mortality rates remained largely unaffected, and selection of antibiotic-resistant pathogens remains a potential disadvantage. Routine SDD in ICU is discouraged. Decontamination of the oropharynx appears to be equally effective.
authors.affiliation: Afd. Interne Geneeskunde, onderafd, Infectieziekten & Aids, Academisch Ziekenhuis, Utrecht. m.bonten@wxs.nl
authors.forename: M J
authors.initials: MJ
authors.lastname: Bonten
authors.forename: D C
authors.initials: DC
authors.lastname: Bergmans
authors.forename: I M
authors.initials: IM
authors.lastname: Hoepelman
authors.forename: E E
authors.initials: EE
authors.lastname: Stobberingh
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods; D003428:Cross Infection / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007362:Intensive Care Units / Q000458:organization & administration / Q000706:statistics & numerical data; D008297:Male; D010608:Pharyngeal Diseases / Q000150:complications / Q000382:microbiology / Q000517:prevention & control; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D012122:Ventilators, Mechanical / Q000009:adverse effects*