Carbamazepine hypersensitivity and the use of lymphocyte proliferation responses.
This report describes a case of multisystem failure in a 5-year-old boy who was being treated with carbamazepine for a seizure disorder. Carbamazepine hypersensitivity was diagnosed from the combination of the clinical constellation and the results of the patient's peripheral blood monocyte proliferation responses to both carbamazepine and a panel of other medications.
Brown
K L
KL
Department of Paediatrics, St Mary's Hospital Medical School, London, UK.
Henderson
D C
DC
Nadel
S
S
Tanveer
A
A
Booy
R
R
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male
D000927:Anticonvulsants; D002220:Carbamazepine