[Long terminal repeat of the human endogenous retrovirus HERV-K in the intron of the ZNF91 gene].
The relative positions of the ZNF91 gene (exon-intron organization) and the HERV-K human endogenous virus long terminal repeat (LTR), which was earlier found to be located in the ZNF91 gene locus, on the EcoRI restriction metric map of the human chromosome 19 were determined with a high resolution. The direction of the ZNF91 gene transcription relative to the chromosome 19 telomeres was determined. The HERV-K LTR was localized to the ZNF91 gene intron 19. The role of retroviral sequences in the evolution of the ZNF91 gene family is discussed.
Khil
P P
PP
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Lebedev
Iu B
IuB
Sverdlov
E D
ED
D001483:Base Sequence; D002888:Chromosomes, Human, Pair 19; D017931:DNA Primers; D018076:DNA, Complementary; D004279:DNA, Viral; D004268:DNA-Binding Proteins / Q000235:genetics*; D020077:Endogenous Retroviruses / Q000235:genetics*; D005091:Exons; D006801:Humans; D007438:Introns; D051741:Kruppel-Like Transcription Factors; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D016615:Telomere; D016335:Zinc Fingers
D017931:DNA Primers; D018076:DNA, Complementary; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; C096797:ZNF91 protein, human