Herpesvirus saimiri as a model for gammaherpesvirus oncogenesis.
Herpesvirus saimiri (HVS) causes T-lymphoproliferative dis-$borders in several New World and Old World primate species and in certain rabbits.In vitro infection leads to permanent growth of primary T cells of primate and human origins. The transformation-relevant proteins of HVS interact with cellular proto-oncoproteins which results in cell growth transformation. In addition, virus-encoded cellular homologues may contribute to transformation or persistence of HVS by altering cellular signal transduction and deregulating cell growth control. Because of the presence of a permissive cell culture system and in vitro Land in vivo transformation assays, HVS provides a unique opportunity to investigate the mechanisms of cancer induction by oncogenic herpesviruses.
Jung
J U
JU
Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772-9102, USA.
Choi
J K
JK
Ensser
A
A
Biesinger
B
B
D000818:Animals; D002471:Cell Transformation, Neoplastic; D004195:Disease Models, Animal; D006567:Herpesvirus 2, Saimiriine / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000209:etiology*; D009857:Oncogenes; D010750:Phosphoproteins / Q000502:physiology; D011323:Primates; D011817:Rabbits; D014764:Viral Proteins / Q000502:physiology
D010750:Phosphoproteins; D014764:Viral Proteins; C092384:tyrosine kinase interacting protein, Saimiriine herpesvirus 2