title: Synthesis and protein kinase C binding activity of benzolactam-V7.
abstract: Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCalpha.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
authors.forename: D
authors.initials: D
authors.lastname: Ma
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: A P
authors.initials: AP
authors.lastname: Kozikowski
authors.forename: N E
authors.initials: NE
authors.lastname: Lewin
authors.forename: P M
authors.initials: PM
authors.lastname: Blumberg
mesh_terms: D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D007527:Isoenzymes / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D015240:Phorbol 12,13-Dibutyrate / Q000378:metabolism; D011485:Protein Binding; D011493:Protein Kinase C / Q000378:metabolism*; D051571:Protein Kinase C-alpha; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D001570:Benzodiazepinones; D007527:Isoenzymes; D011994:Recombinant Proteins; C120089:benzolactam V7; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha