title: Acute renal failure requiring haemodialysis after high doses percutaneous acetic acid injection for hepatocellular carcinoma.
abstract: Recently, ultrasound-guided percutaneous acetic acid injection has been proposed in the treatment of hepatocellular carcinoma as an alternative to percutaneous ethanol injection. We report the case of severe renal failure requiring haemodialysis which occurred in a patient with 4 cm hepatocellular carcinoma treated adequately by high dose percutaneous acetic acid injection. The risk of such a serious side effect, likely related to a direct toxic effect of acetic acid, should be of concern when considering percutaneous treatment of hepatocellular carcinoma. Acute renal failure has been reported as a complication of acetic acid poisoning, but to our knowledge, we report here the first case of acute renal failure following high dose percutaneous acetic acid injection.
authors.affiliation: Department of Gastroenterology, Saint Luc University Hospital, Bruxelles, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Van Hoof
authors.forename: J P
authors.initials: JP
authors.lastname: Joris
authors.forename: Y
authors.initials: Y
authors.lastname: Horsmans
authors.forename: A
authors.initials: A
authors.lastname: Geubel
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D006435:Renal Dialysis
chemical_list: D019342:Acetic Acid