title: Glucolipsin A and B, two new glucokinase activators produced by Streptomyces purpurogeniscleroticus and Nocardia vaccinii.
abstract: During the screening of the natural products for their ability to increase the activity of glucokinase by relieving inhibition by long chain fatty acyl CoA esters (FAC), two novel compounds, glucolipsin A (1) and B (2) were isolated from the butanol extracts of Streptomyces purpurogeniscleroticus WC71634 and Nocardia vaccinii WC65712, respectively. The structures of these two compounds were established by spectroscopic methods and chemical degradation. Glucolipsin A (1) and B (2) relieved the inhibition of glucokinase by FAC with RC50 values of 5.4 and 4.6 microM.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
authors.forename: J
authors.initials: J
authors.lastname: Qian-Cutrone
authors.forename: T
authors.initials: T
authors.lastname: Ueki
authors.forename: S
authors.initials: S
authors.lastname: Huang
authors.forename: K A
authors.initials: KA
authors.lastname: Mookhtiar
authors.forename: R
authors.initials: R
authors.lastname: Ezekiel
authors.forename: S S
authors.initials: SS
authors.lastname: Kalinowski
authors.forename: K S
authors.initials: KS
authors.lastname: Brown
authors.forename: J
authors.initials: J
authors.lastname: Golik
authors.forename: S
authors.initials: S
authors.lastname: Lowe
authors.forename: D M
authors.initials: DM
authors.lastname: Pirnik
authors.forename: R
authors.initials: R
authors.lastname: Hugill
authors.forename: J A
authors.initials: JA
authors.lastname: Veitch
authors.forename: S E
authors.initials: SE
authors.lastname: Klohr
authors.forename: J L
authors.initials: JL
authors.lastname: Whitney
authors.forename: S P
authors.initials: SP
authors.lastname: Manly
mesh_terms: D004187:Disaccharides / Q000096:biosynthesis / Q000494:pharmacology*; D004789:Enzyme Activation; D005285:Fermentation; D005941:Glucokinase / Q000378:metabolism*; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D009615:Nocardia / Q000378:metabolism*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D004187:Disaccharides; C119400:glucolipsin B; C119399:glucolipsin-A; D005941:Glucokinase