Synthesis and protein kinase C binding activity of benzolactam-V7.
Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCalpha.
Ma
D
D
State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Wang
G
G
Wang
S
S
Kozikowski
A P
AP
Lewin
N E
NE
Blumberg
P M
PM
D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001667:Binding, Competitive; D007527:Isoenzymes / Q000378:metabolism*; D008958:Models, Molecular; D015394:Molecular Structure; D015240:Phorbol 12,13-Dibutyrate / Q000378:metabolism; D011485:Protein Binding; D011493:Protein Kinase C / Q000378:metabolism*; D051571:Protein Kinase C-alpha; D011994:Recombinant Proteins / Q000378:metabolism
D001570:Benzodiazepinones; D007527:Isoenzymes; D011994:Recombinant Proteins; C120089:benzolactam V7; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha