[The effect of anti-asthmatic preparations on the proliferation of human peripheral mononuclear cells].
The authors studied the effect of some antiasthmatic drugs (theophylline, budesonide, sodium cromalyne) and beta-carotene in vitro on spontaneous and PHA-induced proliferation of human peripheral blood mononuclears (PBMN). It was found that the drugs had no effect on spontaneous cell proliferation. But budesonide caused a 4-fold and beta-carotene a 6-fold decrease of the index of PHA-stimulated PBMN proliferation. It is concluded that beta-carotene may be used in clinical practice as an anti-inflammatory agent for bronchial asthma treatment.
Uteshev
D B
DB
Russian State Medical University, Moscow, Russia.
Prokof'ev
P S
PS
Kovaleva
V L
VL
Uteshev
B S
BS
Storozhanov
G I
GI
D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D018927:Anti-Asthmatic Agents; D010835:Phytohemagglutinins; D014316:Tritium; D013936:Thymidine