title: Red cell exchange in sickle cell disease.
abstract: Red cell exchange transfusion is frequently of use in the management of patients with sickle cell disease either electively or therapeutically. Modern cell separators allow this procedure to be performed rapidly, effectively and safely. These machines have a number of advantages over manual exchange procedures. The patient remains isovolaemic, there is little loss of plasma or platelets, the procedure is relatively short and in elective circumstances can be performed on an outpatient basis. In this series 66 exchanges were performed on 21 patients with an overall increase in HbA of 70%. The COBE Spectra gave a mean increase in HbA of 77%, with the majority of patients achieving an HbA of > 90% post exchange. Automated redcell exchange was well tolerated by most patients, and adverse effects were limited to symptoms of hypocalcaemia which were easily treated, and to transfusion reactions. Cell separators can therefore be recommended for exchange transfusion in patients with sickle cell disease, who require an increase in HbA levels either prophylactically or therapeutically. They are safe, effective, easy and quick to use.
authors.affiliation: Department of Haematology, Birmingham Children's Hospital NHS Trust, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Lawson
authors.forename: S
authors.initials: S
authors.lastname: Oakley
authors.forename: N A
authors.initials: NA
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Bareford
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000628:therapy*; D017707:Erythrocyte Transfusion / Q000009:adverse effects / Q000295:instrumentation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male
chemical_list: D006454:Hemoglobins