[Clinical-biological differences between invasive ductal carcinomas and breast lobular carcinomas. Preliminary results].
In order to know the biological differences between both histological types, we have analyzed some clinical and biological parameters in tissues of women having infiltrating carcinomas (247 ductal (IDCs) 17 and lobular (ILCs) of the breast. Our preliminary results led us to suggest the following. 1) In negative axillary lymph node involvement (N-) patients, ILCs were more frequently associated with diploidy and the existence of multiple foci; likewise, they had higher pS2 cytosolic levels than IDC; 2) in N+ patients, ILC were associated with multicentricity and had higher concentrations of progesterone receptors and 3) these findings could help to explain us the clinical and biological peculiarities, as well as, the clinical outcome of both histological types.
Ruibal
A
A
Fundación Tejerina, Centro de Patología de la Mama, Madrid, 28003, España.
Núñez
M I
MI
del Río
M f
Mf
Arias
J
J
Martínez
M I
MI
Rabadán
J
J
Tejerina
A
A
D000328:Adult; D000782:Aneuploidy; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000175:diagnosis / Q000235:genetics; D018275:Carcinoma, Lobular / Q000737:chemistry* / Q000175:diagnosis / Q000235:genetics; D002402:Cathepsin D / Q000032:analysis; D004171:Diploidy; D066246:ErbB Receptors / Q000032:analysis; D004967:Estrogens / Q000032:analysis; D005260:Female; D006131:Growth Inhibitors / Q000032:analysis; D006133:Growth Substances / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D015592:Immunoradiometric Assay; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015513:Oncogene Proteins / Q000032:analysis; D011123:Polyploidy; D011506:Proteins / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000032:analysis; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
D004967:Estrogens; D006131:Growth Inhibitors; D006133:Growth Substances; D015513:Oncogene Proteins; D011506:Proteins; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D066246:ErbB Receptors; D010959:Tissue Plasminogen Activator; D002402:Cathepsin D