Salmonella typhimurium IroN and FepA proteins mediate uptake of enterobactin but differ in their specificity for other siderophores.
Salmonella typhimurium possesses two outer membrane receptor proteins, IroN and FepA, which have been implicated in the uptake of enterobactin. To determine whether both receptors have identical substrate specificities, fepA and iroN mutants and a double mutant were characterized. While both receptors transported enterobactin, the uptake of corynebactin and myxochelin C was selectively mediated by IroN and FepA, respectively.
Rabsch
W
W
National Reference Center for Salmonellae and Other Enterics, Robert Koch-Institute, D-38855 Wernigerode, Germany.
Voigt
W
W
Reissbrodt
R
R
Tsolis
R M
RM
Bäumler
A J
AJ
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004758:Enterobactin / Q000031:analogs & derivatives; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005816:Genetic Complementation Test; D007306:Insecticides / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D009154:Mutation; D009930:Organic Chemicals; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D017262:Siderophores / Q000378:metabolism*; D013379:Substrate Specificity; D014161:Transduction, Genetic
D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D007306:Insecticides; D009930:Organic Chemicals; D011956:Receptors, Cell Surface; D017262:Siderophores; C009877:enterobacterin; C029489:enterobactin receptor; D004758:Enterobactin; C044318:corynebactin; D007501:Iron