title: [The need for a review of the procedure for the preventive vaccination of researchers working with Rickettsia prowazekii].
abstract: The analysis of the results of prolonged observations on the prophylactic immunization of employees working with R. prowazekii is presented. The necessity of the differentiated approach to the determination of the immunization schedule and the choice of vaccine is shown. The presence of specific antibodies (Ab) and the level of their titers have been found to be related to the degree of anti-infectious protection. The following characteristics indicate the presence of profound immunological transformation in vaccinees: complement-fixing Ab in titers 1:10 and more and/or immunofluorescent Ab in titers not below 1:180, Ab to protein in the hemagglutination test in titers not below 1:1000. These specific Ab and the level of their titers can be registered after the second injection of live combined typhus vaccine E and the third injection of chemical typhus vaccine. Cases of laboratory infection and their relationship to the character of immunization and the intensity of contacts with R. prowazekii virulent strains are discussed. Attention is drawn to the strict observance of professional safety rules.
authors.affiliation: Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Ignatovich
authors.forename: N K
authors.initials: NK
authors.lastname: Kekcheeva
authors.forename: V A
authors.initials: VA
authors.lastname: Genig
authors.forename: N M
authors.initials: NM
authors.lastname: Balaeva
authors.forename: M E
authors.initials: ME
authors.lastname: Eremeeva
authors.forename: L S
authors.initials: LS
authors.lastname: Belousova
authors.forename: G A
authors.initials: GA
authors.lastname: Penkina
authors.forename: M S
authors.initials: MS
authors.lastname: Umnova
authors.forename: A V
authors.initials: AV
authors.lastname: Tupitsyn
authors.forename: I V
authors.initials: IV
authors.lastname: Tarasevich
mesh_terms: D000047:Academies and Institutes; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D009031:Moscow; D016273:Occupational Exposure / Q000517:prevention & control*; D012108:Research Personnel; D012283:Rickettsia prowazekii / Q000276:immunology* / Q000472:pathogenicity; D012290:Rickettsial Vaccines / Q000276:immunology*; D013997:Time Factors; D014438:Typhus, Epidemic Louse-Borne / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000276:immunology; D017778:Vaccines, Combined / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D012290:Rickettsial Vaccines; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014614:Vaccines, Synthetic