title: Portal vein thrombosis in paroxysmal nocturnal haemoglobinuria.
abstract: A 28-year-old man was hospitalized with nausea, vomiting, abdominal pain and low-grade fever. He had a 6-month history of paroxysmal nocturnal haemoglobinuria (PNH), and laboratory data showed anaemia and liver dysfunction. An abdominal ultrasonography showed ascites and portal vein thrombosis. After receiving antithrombotic treatment, the portal vein thrombosis did not extend. Portal vein thrombosis is very rare but should be considered when we encounter liver dysfunction associated with PNH as well as hepatic vein thrombosis. Ultrasonography is very useful in detecting portal vein thrombosis and facilitating early diagnosis. Warfarin is very effective in preventing exacerbation of portal vein thrombosis in PNH.
authors.affiliation: Division of Haematology, Department of Internal Medicine, Institute of Haematology, Jichi Medical School, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tomizuka
authors.forename: K
authors.initials: K
authors.lastname: Hatake
authors.forename: S
authors.initials: S
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D006457:Hemoglobinuria, Paroxysmal / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D011169:Portal Vein / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D000925:Anticoagulants; D014859:Warfarin