title: Hepatic lesions in young rabbits experimentally infected with rabbit haemorrhagic disease virus.
abstract: Twenty young rabbits (eleven 2-week-old and nine 4-week-old) were experimentally infected with rabbit haemorrhagic disease virus (RHDV) to clarify susceptibility. They were killed chronologically up to 96 hours post-inoculation (PI) and examined for lesions. All inoculated rabbits were clinically normal, but grossly minute white or grey spots were detected throughout the liver. Histologically, the lesions consisted of aggregates of lymphocytes, macrophages and heterophils, with or without acidophilic bodies and necrotic hepatocytes. Immunohistochemically, RHDV antigens were found in the degenerated hepatocytes and in macrophages. The cellular aggregates were considered to be a reaction to necrotic hepatocytes infected with RHDV. It was concluded that some hepatocytes are susceptible to RHDV in young rabbits.
authors.affiliation: Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, 001-0818, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Mikami
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Ochiai
authors.forename: C
authors.initials: C
authors.lastname: Itakura
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D017250:Caliciviridae Infections / Q000473:pathology / Q000662:veterinary*; D005260:Female; D017929:Hemorrhagic Disease Virus, Rabbit; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology* / Q000821:virology; D008297:Male; D011817:Rabbits
chemical_list: D000956:Antigens, Viral