title: [Sensitivity of white mice to influenza virus (A/Aichi/2/68) in aerogenic infection].
abstract: Polydispersed aerosols from allantoic fluid of chick embryos induced with influenza virus with different median weight aerodynamic diameters of corpuscles (0.5, 0.8, 1.1, 2.2, and 6.0 mu are effectively deposited in respiratory organs of mice weighing 18-19 g. The sensitivity of mice of different weight to aerogenic infection with influenza virus (strain A/Aichi/2/68) was virtually the same. The efficacies of aerogenic 50% infective and lethal doses (1.8-2.5 lg) for mice of the same weight were different. The sensitivity of mice to aerogenic infection and of developing chicken embryos to the virus (ID50 = EID50) is the same. Mice weighing 10-19 g can be infected via airways with adapted influenza virus in studies of therapeutic and prophylactic effects of drugs.
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: O G
authors.initials: OG
authors.lastname: P'iankova
authors.forename: L E
authors.initials: LE
authors.lastname: Bulychev
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
authors.forename: O V
authors.initials: OV
authors.lastname: P'iankov
authors.forename: V A
authors.initials: VA
authors.lastname: Zhukov
authors.forename: A B
authors.initials: AB
authors.lastname: Ryzhikov
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: L A
authors.initials: LA
authors.lastname: Kotliarov
authors.forename: V D
authors.initials: VD
authors.lastname: Poryvaev
mesh_terms: D000336:Aerosols; D000818:Animals; D002642:Chick Embryo; D009980:Influenza A virus / Q000472:pathogenicity*; D019570:Inhalation Exposure; D051379:Mice; D012137:Respiratory System / Q000821:virology
chemical_list: D000336:Aerosols