The influence of highly active antiretroviral therapy on AIDS-associated Kaposi's sarcoma.
To assess the clinical and biological benefit of highly active antiretroviral therapy on AIDS-associated Kaposi's sarcoma (KS), 13 patients with AIDS-associated Kaposi's sarcoma (five pulmonary KS and eight cutaneous KS) were prospectively followed for a mean duration of 12 months. Six patients were treated with specific anti-KS chemotherapy before or simultaneously with the introduction of antiretroviral therapy. Clinical response was assessed according to the AIDS Clinical Trial Group (ACTG) criteria. CD4 cell counts, plasma HIV-1 RNA and human herpesvirus 8 (HHV-8) viraemia were measured at baseline and at different points. Among patients with pulmonary KS, we observed three complete responses (CR), one partial response (PR) and one progression. The median survival time after the diagnosis of pulmonary KS was 15 months with a median duration of the response after the discontinuation of specific chemotherapy for KS of 8 months. Among patients with cutaneous KS, we observed four CR, three PR and one stable response. A complete response was significantly associated with a reversal in HHV-8 viraemia (five of six vs. one of six; P = 0.02, Mann-Whitney test).
Dupin
N
N
Service de Dermato-Vénéréologie, Hôpital Tarnier-Cochin, Paris, France; Laboratoire de Virologie, Groupe Hospitalier Pitié-Salpétrière, Paris, France. nicolas@icr.ac.uk
Rubin De Cervens
V
V
Gorin
I
I
Calvez
V
V
Pessis
E
E
Grandadam
M
M
Rabian
C
C
Viard
J P
JP
Huraux
J M
JM
Escande
J P
JP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D000328:Adult; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000235:genetics; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D012514:Sarcoma, Kaposi / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome; D014766:Viremia / Q000150:complications / Q000188:drug therapy
D017320:HIV Protease Inhibitors; D012367:RNA, Viral