Multidrug resistance: Versatile drug sensors of bacterial cells.
One way that bacteria resist antimicrobial agents involves 'drug sensors', proteins that bind a range of structurally unrelated antimicrobial drugs and induce expression of multidrug resistance pumps. The basis for drug recognition is now becoming clear from the recently determined crystal structure of a drug sensor.
Lewis
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Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA.
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins / Q000378:metabolism; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D002412:Cations; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple / Q000502:physiology*; D026901:Membrane Transport Proteins; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C098722:BmrR protein, bacteria; D002352:Carrier Proteins; D002412:Cations; D026901:Membrane Transport Proteins; D015534:Trans-Activators; C075041:Bmr protein, Bacillus subtilis