title: Recurrent convulsions and cardiac conduction disturbances after propafenone overdose.
abstract: Propafenone is a class Ic antiarrhythmic agent which also exhibits beta-adrenergic and fast sodium channel blockade. We report a case of severe poisoning in a 24-y-old woman who suffered a seizure 1 h after the intentional ingestion of 2.7 g propafenone, and had a recurrence of convulsion on arrival at the hospital. She also developed severe arrhythmia during her hospital course. She recovered uneventfully with supportive treatment.
authors.affiliation: Clinical Toxicology Unit-Toxicovigilance/Intensive Care Unit, Centre Hospitalier Universitaire, Reims, France.
authors.forename: M O
authors.initials: MO
authors.lastname: Rambourg-Schepens
authors.forename: F
authors.initials: F
authors.lastname: Grossenbacher
authors.forename: M
authors.initials: M
authors.lastname: Buffet
authors.forename: D
authors.initials: D
authors.lastname: Lamiable
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D011405:Propafenone / Q000506:poisoning*; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone