title: In vivo micro-imaging using alternating navigator echoes with applications to cancellous bone structural analysis.
abstract: In micro-magnetic resonance imaging of cancellous bone architecture, involuntary subject motion even on a sub-millimeter scale is detrimental and generally precludes accurate quantification of architectural parameters. In this work a navigator-assisted three-dimensional spin-echo technique is described and evaluated for imaging at 137 microm resolution in humans. The method is based on gradient navigator echoes following the spin-echo readout for sensing translational displacements alternately in x- and y-directions with a spatial resolution of 273 microm and a temporal resolution of 0.2 sec. The technique is shown to improve micro-images of the distal forearm significantly and to enhance accuracy and reproducibility of bone volume fraction, transverse contiguity, and tubularity, parameters introduced in prior work to characterize the trabecular network. It is further shown that a fourfold reduction in navigator sampling time, along with zero-filling, improves the accuracy of the navigator correction while reducing the minimum pulse repetition time or gradient heating. The data indicate that navigator-assisted micro-imaging is capable of effectively correcting sub-millimeter displacements in micro-imaging.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Song
authors.forename: F W
authors.initials: FW
authors.lastname: Wehrli
mesh_terms: D000328:Adult; D000465:Algorithms; D001842:Bone and Bones / Q000033:anatomy & histology*; D003198:Computer Simulation; D004578:Electron Spin Resonance Spectroscopy; D005240:Feasibility Studies; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009068:Movement; D019047:Phantoms, Imaging; D011884:Radius / Q000033:anatomy & histology; D015203:Reproducibility of Results; D013997:Time Factors