Iatrogenic hyperadrenocorticism in 28 dogs.
Twenty-eight dogs with iatrogenic hyperadrenocorticism were studied. The most common clinical signs were cutaneous lesions (27/28), polydipsia (21/28), polyuria (19/28), and lethargy (16/28). The most predominant findings on biochemical profile were elevated alkaline phosphatase (ALP, 15/28) and alanine transferase (ALT, 14/28); hypercholesterolemia (14/28); elevated aspartate transferase (AST, 12/28); and elevated triglycerides (12/18). Baseline cortisol levels of all 28 dogs were at the lower end of the reference range and exhibited suppressed or no response to adrenocorticotropic hormone (ACTH) stimulation. The mean time for each dog to show initial improvement of clinical signs after corticosteroid withdrawal was six weeks, with another mean time of 12 weeks to demonstrate complete remission.
Huang
H P
HP
Department of Veterinary Medicine, National Taiwan University, Taipei.
Yang
H L
HL
Liang
S L
SL
Lien
Y H
YH
Chen
K Y
KY
D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000308:Adrenocortical Hyperfunction / Q000139:chemically induced / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000139:chemically induced* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D007049:Iatrogenic Disease / Q000662:veterinary*; D008297:Male
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone