The effects of ultraviolet radiation on the human immune system.
The adverse outcome of increased ultraviolet (UV) irradiation on human health is currently of concern. While many experiments have been carried out in rodent models, fewer have been designed to test the effects of UV exposure in human subjects. This review concentrates on the modulations induced in the human immune system by UV, and outlines changes in antigen presentation by Langerhans cells and macrophages, in the activities of natural killer cells and T cells, and in cytokine regulation. Precautionary measures which might be taken to help protect people against the immunosuppressive action of UV irradiation are considered.
Duthie
M S
MS
Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.
Kimber
I
I
Norval
M
M
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D007694:Killer Cells, Natural / Q000528:radiation effects; D007801:Langerhans Cells / Q000528:radiation effects; D008264:Macrophages / Q000528:radiation effects; D051379:Mice; D051381:Rats; D012643:Selenium / Q000627:therapeutic use; D012867:Skin / Q000276:immunology* / Q000378:metabolism / Q000528:radiation effects*; D013237:Stereoisomerism; D013473:Sunscreening Agents / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014560:Urocanic Acid / Q000378:metabolism
D000975:Antioxidants; D016207:Cytokines; D013473:Sunscreening Agents; D014560:Urocanic Acid; D012643:Selenium