Somatic gene therapy in animal models of Parkinson's disease.
Gene therapy in Parkinson's disease (PD) emerged about 10 years ago but until now, no clinical trials are under way, because most approaches have failed to show long-term therapeutic effects in PD animal models and because safety concerns precluded the use in humans so far. This review tries to give an overview on the development of different strategies in gene therapy in PD animal models and point out new and possibly more successful directions, including the transplantation of neural precursor cells and pig tissue.
Bauer
M
M
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.
Ueffing
M
M
Meitinger
T
T
Gasser
T
T
D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D004298:Dopamine / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods*; D018696:Neuroprotective Agents / Q000627:therapeutic use; D010302:Parkinson Disease, Secondary / Q000628:therapy*; D051381:Rats; D013234:Stem Cells / Q000166:cytology; D014183:Transplantation, Heterologous
D018696:Neuroprotective Agents; D004298:Dopamine