title: Signal transduction pathway in human middle ear cholesteatoma.
abstract: Phospholipase C-gamma1 plays a central role in signal transduction, and it is important in cellular growth, differentiation, and proliferation. Human cholesteatoma in the middle ear is characterized by the presence of a keratinizing epithelium that is believed to have hyperproliferative properties. The purpose of this study is to elucidate the distribution of phospholipase C-gamma1 in cholesteatoma matrix and deep meatal skin with Western blot analysis and immunohistochemistry. In conclusion, overexpression of phospholipase C-gamma1 in cholesteatoma matrix suggests a possible derangement of enhanced growth signal transduction in keratinocytes.
authors.affiliation: Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea.
authors.forename: E N
authors.initials: EN
authors.lastname: Myers
authors.forename: K
authors.initials: K
authors.lastname: Park
authors.forename: Y m
authors.initials: Ym
authors.lastname: Chun
authors.forename: D h
authors.initials: Dh
authors.lastname: Lee
authors.forename: S c
authors.initials: Sc
authors.lastname: Hwang
mesh_terms: D000911:Antibodies, Monoclonal; D015153:Blotting, Western; D002455:Cell Division; D018424:Cholesteatoma, Middle Ear / Q000503:physiopathology*; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000502:physiology; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D010738:Type C Phospholipases