Stability of pilocarpine ophthalmic solutions.
The stability of pilocarpine and pilocarpine-timolol eyedrop preparations available on the Argentine market was studied. A high-performance liquid chromatographic method that allows the estimation of pilocarpine in the presence of degradation products was used for the study according to the preestablished design. It was found that pilocarpine solutions are stable, while pilocarpine in association with timolol shows significant degradation.
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Instituto Nacional de Medicamentos, Administración Nacional de Medicamentos, Alimentos y Tecnología Médica, Buenos Aires, Argentina.
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D001118:Argentina; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D004355:Drug Stability; D009883:Ophthalmic Solutions / Q000737:chemistry*; D010277:Parasympathomimetics / Q000737:chemistry*; D010862:Pilocarpine / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013565:Sympatholytics / Q000737:chemistry; D013999:Timolol / Q000737:chemistry*
D009883:Ophthalmic Solutions; D010277:Parasympathomimetics; D012996:Solutions; D013565:Sympatholytics; D010862:Pilocarpine; D013999:Timolol