Comparative role of peptide leukotrienes and histamine in the development of nasal mucosal swelling in nasal allergy.
To evaluate the importance of histamine and peptide leukotrienes (LTs) in the development of nasal mucosal swelling in nasal allergy, H1 receptor antagonist (mequitazine, 6 mg, in 2 divided doses, Rhône-Poulenc Rorer, France) and LT receptor antagonist (ONO-1078, pranlukast, 450 mg, in 2 divided doses, Ono Pharmaceutical Co, Ltd, Osaka) were administered orally for 7 days to 16 subjects with perennial nasal allergy to house dust mites, and the effects of receptor blockers of these chemical mediators on the effective cross-sectional area of the nasal cavity (ECA) at rest, at exercise load, at antigen challenge, and at exercise load following antigen challenge were studied. After the administration of H1 receptor antagonist, ECAs at all measurement points slightly increased, but no statistical significance was observed. On the other hand, LT receptor antagonist inhibited ECAs 10 minutes after exercise load, just after the end of antigen challenge, 10 minutes later, and at exercise load following antigen challenge with statistical significance. These results suggest that LTs are involved markedly, and histamine slightly, in the development of nasal mucosal swelling in nasal allergy.
Numata
T
T
Department of Otorhinolaryngology, School of Medicine, Chiba University, Chiba City, Japan.
Konno
A
A
Yamakoshi
T
T
Hanazawa
T
T
Terada
N
N
Nagata
H
H
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D002867:Chromones / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D020024:Leukotriene Antagonists / Q000494:pharmacology; D015289:Leukotrienes / Q000502:physiology*; D008297:Male; D008925:Mites; D009297:Nasal Mucosa / Q000378:metabolism / Q000503:physiopathology*; D009299:Nasal Provocation Tests; D010640:Phenothiazines / Q000494:pharmacology; D005082:Physical Exertion; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology / Q000503:physiopathology*; D012912:Sneezing
D000485:Allergens; D002867:Chromones; D006634:Histamine H1 Antagonists; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D010640:Phenothiazines; D006632:Histamine; C047681:pranlukast; C006069:mequitazine