Effects of prosthetic reconstruction of the abdominal wall on respiratory mechanics in rats.
Respiratory mechanics and thoracoabdominal morphometry were determined in four sets of animal experiments before and after surgery. In group RRA the rectus abdominus muscles were removed; in RRAH rats the muscle resection was followed by lung hyperinflation; in PPM animals the defect was repaired by suturing a polypropylene mesh (Marlex); and in PPMH lung hyperinflation was performed after abdominal wall reconstruction. Lung and chest wall elastances, and chest wall viscoelastic/inhomogeneous pressures increased in RRA, RRAH and PPM groups. Static lung elastance was progressively smaller in the following order: RRA, PPM, and PPMH. In conclusion, removal of the rectus abdominus muscles and abdominal wall reconstruction could account for higher energy losses against viscoelastic and elastic forces acting on the chest wall, and these are related to a cephalad deviation of the diaphragm. Furthermore, hyperinflation reverses lung elastic modification after abdominal wall reconstruction with PPM, without beneficial effects in the presence of abdominal wall defect.
Rocco
P R
PR
Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Centro de Ciências da Saúde, RJ, Brazil.
Fonseca
S M
SM
Pinto
A P
AP
Medeiros
A S
AS
Contador
R S
RS
Zin
W A
WA
D000009:Abdominal Muscles / Q000601:surgery*; D000818:Animals; D004548:Elasticity; D008168:Lung / Q000502:physiology; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D011312:Pressure; D019919:Prosthesis Implantation; D012123:Pulmonary Ventilation / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D015656:Respiratory Mechanics / Q000502:physiology*; D013909:Thorax / Q000502:physiology