[The correlation between t(14;18) chromosomal translocation and hepatocarcinoma].
OBJECTIVE
To study the correlation between t(14;18) chromosomal translocation and the occurrence of hepatocarcinoma.


METHODS
bcl-2/JH fusion gene in 54 cases of hepatocarcinoma including 40 cases of hepatocellular carcinoma(HCC) and 14 cases of cholangicellular carcinoma (CCC) were investigated using seminested in situ PCR.


RESULTS
Bcl-2/JH fusion gene was present in 25% (10/40) HCC and negative in CCC.


CONCLUSIONS
These findings indicated that t(14;18) chromosomal translocation might play a role in the pathogenesis of HCC but seemed to bear no relation with CCC. mbr and mcr are the two important breakpoints of bcl-2 gene in HCC.
Guo
L
L
Department of Pathology, Zhujiang Hospital, First Military University, Guangzhou, 510282 P.R. China. gllg@gzsums.edu.cn
Xiao
S
S
Guo
Y
Y
D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic