title: A transient increase in endogeneous erythropoietin levels after paediatric liver transplantation.
abstract: We investigated whether liver transplantation affects endogeneous erythropoietin (EPO) synthesis. Serum EPO levels were measured before transplantation and during the peri-transplant period in ten consecutive paediatric patients who had received a liver allograft without recombinant EPO therapy. All patients were anaemic on post-operative day 1 (POD 1); however, the haemoglobin levels of three patients gradually increased and required phlebotomy on POD 5-9. The serum levels of EPO in all patients were within the normal range before surgery, but six of the ten patients had a transient increased level of EPO at 1248 h after transplantation. A transient increase of endogeneous EPO following paediatric liver transplantation may be associated with extramedullary erythropoiesis in human liver grafts.
authors.affiliation: Department of Surgery, University of Queensland, Brisbane. clcltf@ms17.hinet.net
authors.forename: S
authors.initials: S
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Noguch
authors.forename: Y
authors.initials: Y
authors.lastname: Morotomi
authors.forename: R
authors.initials: R
authors.lastname: Lord
authors.forename: J
authors.initials: J
authors.lastname: Board
authors.forename: C L
authors.initials: CL
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Jawan
authors.forename: T L
authors.initials: TL
authors.lastname: Pan
authors.forename: Y S
authors.initials: YS
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Tatsuma
authors.forename: S
authors.initials: S
authors.lastname: Kitano
authors.forename: S V
authors.initials: SV
authors.lastname: Lynch
mesh_terms: D002648:Child; D002675:Child, Preschool; D004921:Erythropoietin / Q000097:blood*; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D014184:Transplantation, Homologous
chemical_list: D004921:Erythropoietin