[The biological characterization of HIV-1 isolated in patients with a rapid clinical evolution].
The biological characteristics of 11 HIV-1 strains isolated from patients with a fast clinical evolution to AIDS were studied. The viral isolates were classified according to their replication kinetics and cell tropism. Taking into account these criteria, it was observed that 8 of the isolated strains (72.7%) were of rapid high growth (RH) or slow low 3 (SL3) with preferential tropism to the lymphocytic stock, as it corresponds to AIDS patients. 3 (27.3%) had characteristics of slow low 1 (SL1). The cytopathogenicity of the strains was studied in the MT4 cellular line, and it was observed that most of them (72.7%) were syncytium-inducing strains (SI), which allowed to prove the in vivo and in vitro relation of the biological properties. It was not so in 3 of the cultures (27.3%) that behaved as non-syncytium inducers.
Lobaina Barthelemy
L
L
Laboratorio de Investigaciones del SIDA, San José de las Lajas, Cuba.
Dubed Echevarría
M
M
Vilarrubia Montes de Oca
O L
OL
Navea Leyva
L
L
Díaz Torres
H M
HM
Izquierdo Márquez
M
M
Noa Romero
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D018450:Disease Progression; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D013997:Time Factors; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication