In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum.
The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.
Ringwald
P
P
Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Laboratoire Associé Francophone 302, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon. oceac@camnet.cm
Eboumbou
E C
EC
Bickii
J
J
Basco
L K
LK
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D004338:Drug Combinations; D009287:Naphthyridines; C027871:pyronaridine