title: CSF 5-HIAA correlates with neuroticism in depressed patients.
abstract: BACKGROUND
  To examine for relationships between neurotransmitters and personality.
  
  
  METHODS
  27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ).
  
  
  RESULTS
  CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores.
  
  
  CONCLUSIONS
  Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression.
  
  
  CONCLUSIONS
  The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.
authors.affiliation: Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07019, USA.
authors.forename: A
authors.initials: A
authors.lastname: Roy
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D009497:Neurotic Disorders / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000175:diagnosis; D010555:Personality Inventory; D012720:Severity of Illness Index
chemical_list: D006897:Hydroxyindoleacetic Acid