Serum level of sELAM-1 in psoriatic patients correlates with disease activity.
BACKGROUND
Endothelial leucocyte adhesion molecule-1 (ELAM-1) acts as an adhesion ligand for neutrophils and monocytes and the expression of this molecule on the vascular endothelium may reflect its ability to recruit neutrophils from circulation. The next step is the transendothelial migration of neutrophils into lesional psoriatic skin. ELAM-1 may also exist in a soluble form.


METHODS
We determined the serum levels of ELAM-1 by ELISA in 41 patients with psoriasis and 20 controls.


RESULTS
Patients with acute psoriasis displayed higher levels of ELAM-1 (85.45 +/- 47.72 ng/ml) than controls (36.02 +/- 15.60 ng/ml) and patients with chronic disease (61.24 +/- 27.91 ng/ml). In 25 patients we measured the serum level of ELAM-1 twice: at the beginning and after treatment of the disease and we did not find any significant changes. We also found a correlation between serum ELAM-1 and PASI score.


CONCLUSIONS
These data suggest that there is a high serum level of E-selectin in psoriatic subjects even after clearing of the disease. Serum E-selectin may reflect the general activation of endothelial cells in the disease and may be a new sensitive marker of disease activity.
Krasowska
D
D
Department of Dermatology, Medical University of Lublin, Poland.
Pietrzak
A
A
Lecewicz-Torun
B
B
D000208:Acute Disease; D000279:Administration, Cutaneous; D000287:Administration, Topical; D000328:Adult; D000875:Anthralin / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002465:Cell Movement; D002908:Chronic Disease; D019040:E-Selectin / Q000097:blood*; D004730:Endothelium, Vascular / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D012867:Skin / Q000276:immunology
D000893:Anti-Inflammatory Agents; D019040:E-Selectin; D000875:Anthralin