title: Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2.
abstract: AIDS-related primary central nervous system lymphoma (AIDS PCNSL) is a rapidly fatal disease. Conventional therapeutic modalities offer little and new approaches are needed. Previous work has shown that zidovudine (AZT) in combination with other agents is active in retroviral lymphomas. Epstein-Barr virus (EBV) is detected in tumor tissue and cerebrospinal fluid of AIDS PCNSL patients. In a preliminary in vitro study we found that an Epstein-Barr virus-positive B cell line underwent apoptosis on coculture with AZT. This effect was accentuated by the addition of ganciclovir (GCV). We treated five patients with AIDS PCNSL with a regimen consisting of parenteral zidovudine (1.6 g twice daily), ganciclovir (5 mg/kg twice daily), and interleukin 2 (2 million units twice daily). Four of five had an excellent response. Two patients are alive and free of disease 22 and 13 months later; another responded on two separate occasions, 5 months apart, and the last patient responded with a 70-80% regression of tumor but could not be maintained on therapy owing to myelosuppression. We conclude that parenteral zidovudine, ganciclovir, and interleukin 2 is an active combination for AIDS-related central nervous system lymphoma.
authors.affiliation: Division of Hematology/Oncology, University of Miami School of Medicine/Jackson Memorial Hospital, Florida 33136, USA.
authors.forename: L
authors.initials: L
authors.lastname: Raez
authors.forename: L
authors.initials: L
authors.lastname: Cabral
authors.forename: J P
authors.initials: JP
authors.lastname: Cai
authors.forename: H
authors.initials: H
authors.lastname: Landy
authors.forename: G
authors.initials: G
authors.lastname: Sfakianakis
authors.forename: G E
authors.initials: GE
authors.lastname: Byrne
authors.forename: J
authors.initials: J
authors.lastname: Hurley
authors.forename: E
authors.initials: E
authors.lastname: Scerpella
authors.forename: D
authors.initials: D
authors.lastname: Jayaweera
authors.forename: W J
authors.initials: WJ
authors.lastname: Harrington
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007376:Interleukin-2 / Q000627:therapeutic use*; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy*; D008297:Male; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D007376:Interleukin-2; D015215:Zidovudine; D015774:Ganciclovir