title: Regulation of inner ear fluid in the guinea pig cochlea after the application of saturated NaCl solution to the round window membrane.
abstract: The regulation of K+ and Na+ in the inner ear fluid of the guinea pig was studied after the application of saturated NaCl solution to the round window membrane. K+ and Na+ activities in the scala tympani increased rapidly and then decreased. K+ activity in the scala media increased immediately, but Na+ activity continued to increase during the period of observation. K+ activity in the scala vestibuli continued to increase in the observation period. Na+ activity in the scala vestibuli increased and then decreased. The endocochlear potential decreased immediately to approximately 20% of its initial level. Total activities of K+ and Na+ increased immediately and then decreased in both the scala tympani and scala media. The total activity of K+ and Na+ increased slowly and showed no regulatory decrease in the scala vestibuli. Thus, changing patterns in the total activity of K+ and Na+ were similar for the scala tympani and scala media, but not for the scala media and the scala vestibuli. Different patterns of K+ and Na+ activities among the three scalae indicate that their mechanisms for regulating inner ear fluid differ.
authors.affiliation: Department of Otorhinolaryngology, Yamaguchi Red Cross Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hisashi
authors.forename: S
authors.initials: S
authors.lastname: Komune
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Kimitsuki
authors.forename: S
authors.initials: S
authors.lastname: Komiyama
mesh_terms: D000818:Animals; D001489:Basilar Membrane / Q000378:metabolism*; D004710:Endolymph / Q000378:metabolism*; D006168:Guinea Pigs; D009994:Osmolar Concentration; D010498:Perilymph / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D012405:Round Window, Ear / Q000378:metabolism*; D012965:Sodium Chloride / Q000493:pharmacokinetics*; D013997:Time Factors; D014432:Tympanic Membrane / Q000378:metabolism*
chemical_list: D015221:Potassium Channels; D012965:Sodium Chloride