title: Isoniazid induced pellagra despite pyridoxine supplementation.
abstract: Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed--sometimes with life-threatening consequences. We report a case of isoniazid-induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. The possible mechanisms of isoniazid induced pellagra are discussed.
authors.affiliation: Department of Dermatology, Ealing Hospital, Southall, UK.
authors.forename: A
authors.initials: A
authors.lastname: Darvay
authors.forename: T
authors.initials: T
authors.lastname: Basarab
authors.forename: J M
authors.initials: JM
authors.lastname: McGregor
authors.forename: R
authors.initials: R
authors.lastname: Russell-Jones
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002990:Clobetasol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use; D010383:Pellagra / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011736:Pyridoxine / Q000008:administration & dosage*; D013473:Sunscreening Agents / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D013473:Sunscreening Agents; D009536:Niacinamide; D002990:Clobetasol; D011736:Pyridoxine; D007538:Isoniazid