Serum G-CSF levels are not increased in patients with antibody-induced neutropenia unless they are suffering from infectious diseases.
By the use of a G-CSF-specific ELISA we determined the serum granulocyte-colony stimulating factor (G-CSF) levels in 63 patients with antibody-induced neutropenia including neonatal immune neutropenia, autoimmune neutropenia, and drug-induced immune neutropenia. In the sera of 20 patients, elevated G-CSF levels of 60-1006 pg/ml (normal <39 pg/ml) were observed. These patients suffered from infectious diseases at the time of blood collection. G-CSF levels normalized after successful antibiotic treatment, indicating that increased G-CSF production in patients with immune neutropenia may be primarily the result of infection and not of neutropenia.
Bux
J
J
Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig University Giessen, Germany. juergen.bux@immunologie.med.uni-giessen.de
Hofmann
C
C
Welte
K
K
D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000097:blood* / Q000209:etiology / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007239:Infections / Q000097:blood*; D007518:Isoantibodies / Q000276:immunology; D009503:Neutropenia / Q000097:blood* / Q000139:chemically induced / Q000276:immunology
D001323:Autoantibodies; D007518:Isoantibodies; D016179:Granulocyte Colony-Stimulating Factor