title: Alpha, beta-unsaturated aldehydes mediate inducible expression of glutathione S-transferase in hepatoma cells through activation of the antioxidant response element (ARE).
authors.affiliation: Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Tjalkens
authors.forename: S W
authors.initials: SW
authors.lastname: Luckey
authors.forename: D J
authors.initials: DJ
authors.lastname: Kroll
authors.forename: D R
authors.initials: DR
authors.lastname: Petersen
mesh_terms: D000171:Acrolein / Q000378:metabolism / Q000494:pharmacology; D000447:Aldehydes / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D005982:Glutathione Transferase / Q000096:biosynthesis / Q000235:genetics*; D007527:Isoenzymes; D008969:Molecular Sequence Data; D051381:Rats; D020218:Response Elements; D014407:Tumor Cells, Cultured
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D007527:Isoenzymes; C051750:2-hexenal; D000171:Acrolein; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha; C041116:leukotriene-C4 synthase; C027576:4-hydroxy-2-nonenal