title: When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis.
abstract: Regulatory pathways involving two-component histidine kinase/response regulator proteins of Bacillus subtilis are highly interconnected and form a signal transduction network controlling stationary-phase adaptive responses. These include chemotaxis and motility, degradative enzyme synthesis, antibiotic production, natural competence for DNA uptake, and sporulation. Many of these responses are mutually exclusive, with different control levels involving protein-environment, protein-protein and protein-DNA interactions, allowing the bacteria to adapt rapidly to environmental changes.
authors.affiliation: Unité de Biochimie Microbienne, URA 1300 du Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France. tmsadek@pasteur.fr
authors.forename: T
authors.initials: T
authors.lastname: Msadek
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001412:Bacillus subtilis / Q000166:cytology / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D002633:Chemotaxis / Q000502:physiology; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D000071677:Histidine Kinase; D010447:Peptide Hydrolases / Q000378:metabolism; D010455:Peptides / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D014169:Transformation, Bacterial
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D010455:Peptides; D010710:Phosphates; D011494:Protein Kinases; D000071677:Histidine Kinase; D010447:Peptide Hydrolases