title: High serum levels of M-CSF and G-CSF in Kawasaki disease.
abstract: To examine any role of macrophage colony-stimulating factor (M-CSF), in the immune responses in Kawasaki disease (KD), we serially assayed M-CSF and several related cytokines using ELISA. In 10 paediatric patients with KD the level of M-CSF was significantly higher in the acute phase than in the convalescent phase (1476.1 +/- 443.6 v 805.0 +/- 184.7 U/ml). Higher levels of serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 were also found in the acute phase. These results suggest that M-CSF, G-CSF and interleukin-6, derived from monocytes as monokines or derived from vascular endothelial cells, might play an important role in the acute phase of KD.
authors.affiliation: Department of Paediatrics, Jichi Medical School, Zama, Japan. iga-hiro@jichi.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Igarashi
authors.forename: K
authors.initials: K
authors.lastname: Hatake
authors.forename: H
authors.initials: H
authors.lastname: Tomizuka
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Gunji
authors.forename: M Y
authors.initials: MY
authors.lastname: Momoi
mesh_terms: D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*; D013926:Thrombopoietin / Q000097:blood
chemical_list: D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor; D013926:Thrombopoietin