High serum levels of M-CSF and G-CSF in Kawasaki disease.
To examine any role of macrophage colony-stimulating factor (M-CSF), in the immune responses in Kawasaki disease (KD), we serially assayed M-CSF and several related cytokines using ELISA. In 10 paediatric patients with KD the level of M-CSF was significantly higher in the acute phase than in the convalescent phase (1476.1 +/- 443.6 v 805.0 +/- 184.7 U/ml). Higher levels of serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 were also found in the acute phase. These results suggest that M-CSF, G-CSF and interleukin-6, derived from monocytes as monokines or derived from vascular endothelial cells, might play an important role in the acute phase of KD.
Igarashi
H
H
Department of Paediatrics, Jichi Medical School, Zama, Japan. iga-hiro@jichi.ac.jp
Hatake
K
K
Tomizuka
H
H
Yamada
M
M
Gunji
Y
Y
Momoi
M Y
MY
D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000097:blood; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*; D013926:Thrombopoietin / Q000097:blood
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor; D013926:Thrombopoietin