[Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke].
Semax is the first domestic nootropic drug of an unexhausted type from the group of neuropeptides. In experimental studies it showed angioprotective, antihypoxic and neurotrophic activity in the doses 100-150 micrograms/kg. A combined clinical-electrophysiologic study revealed its high efficiency in acute ischemic stroke. A clinical trial was performed of immunobiochemical mechanisms of neuroprotective properties of Semax in acute period of ischemic stroke. A retrospective comparative clinicoimmunobiochemical analysis provided objective data on the molecular level on activating influence of Semax on antiinflammatory postischemic reactions in the brain. Shifting neuromediatory balance toward a prevalence of the antiinflammatory agents (interleukin-10, tumor necrosis factor-alpha) over the factors maintaining the inflammation (interleukin-8, C-reactive protein).
Miasoedova
N F
NF
Skvortsova
V I
VI
Nasonov
E L
EL
Zhuravleva
E Iu
EIu
Grivennikov
I A
IA
Arsen'eva
E L
EL
Sukhanov
I I
II
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000276:immunology*; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000276:immunology*; D002097:C-Reactive Protein / Q000134:cerebrospinal fluid / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid / Q000276:immunology; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D012189:Retrospective Studies; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000276:immunology
D018696:Neuroprotective Agents; D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D002097:C-Reactive Protein