Etiology of ovarian cancer: a proposed mechanism.
The majority of ovarian cancers are derived from ovarian surface epithelial cells that are sequestered in inclusion cysts within the ovarian stroma. We propose that the Fas/Fas ligand system is responsible for the normal elimination of these inclusion cysts through apoptosis, thereby removing potential sites of ovarian tumors. Furthermore, we hypothesize that the failure of the Fas/Fas ligand's apoptotic signaling mechanism leads to the persistence of these inclusion cysts in the stroma, and the onset of ovarian tumorigenesis.
Ghahremani
M
M
Banting & Best Department of Medical Research, University of Toronto, Ontario, Canada. manda.ghahremani@utoronto.ca
Foghi
A
A
Dorrington
J H
JH
D017209:Apoptosis; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D008954:Models, Biological; D010048:Ovarian Cysts / Q000150:complications / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010060:Ovulation; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor