title: GATA transcription factors and cardiac development.
abstract: Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.
authors.affiliation: Institut de recherches cliniques de Montréal, Laboratoire de développement et différenciation cardiaques, Québec, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Charron
authors.forename: M
authors.initials: M
authors.lastname: Nemer
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology; D006332:Cardiomegaly / Q000235:genetics; D002645:Chickens; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D050991:GATA4 Transcription Factor; D050992:GATA5 Transcription Factor; D050993:GATA6 Transcription Factor; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology* / Q000254:growth & development; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014981:Xenopus; D029867:Xenopus Proteins
chemical_list: D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; C494752:GATA-5a protein, Xenopus; C494753:GATA-5b protein, Xenopus; D050991:GATA4 Transcription Factor; C494751:GATA4 protein, Xenopus; D050992:GATA5 Transcription Factor; C494755:GATA5 protein, human; D050993:GATA6 Transcription Factor; C494758:GATA6 protein, Xenopus; C494759:GATA6 protein, human; C494756:Gata5 protein, mouse; C494757:Gata5 protein, rat; C494760:Gata6 protein, mouse; D000072576:Homeobox Protein Nkx-2.5; D018398:Homeodomain Proteins; C092720:NKX2-5 protein, Xenopus; C095552:NKX2-5 protein, human; C484469:Nkx2-5 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins