The interaction of immunomodulatory muramyl dipeptide with peripheral 5-HT receptors: overview of the current state.
Immunomodulator muramyl dipeptide (MDP) exerts also pronounced neuropharmacological activities which are probably mediated by an interaction with 5-HT receptors. Some of these effects are considered as undesirable by its clinical use. More precise information concerning MDP effects on 5-HT receptors with respect to their many subtypes could result from studies using isolated organs in vitro. Earlier conducted studies of this type provided data that are concisely overviewed and reinterpreted here from the view of current 5-HT receptor classification. Since new 5-HT receptor types have emerged recently, new studies are under way. The results might contribute to the development of novel immunomodulatory drugs devoid of adverse effects.
Sevcík
J
J
Institute of Pharmacology, Academy of Sciences of the Czech Republic, Prague. sevcik@biomed.cas.cz
Masek
K
K
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D011985:Receptors, Serotonin / Q000145:classification* / Q000187:drug effects* / Q000502:physiology
D000276:Adjuvants, Immunologic; D011985:Receptors, Serotonin; D000119:Acetylmuramyl-Alanyl-Isoglutamine