Topical aminoglycosides in the management of active mucosal chronic suppurative otitis media.
Debate has currently re-emerged following a renewed warning issued from the Committee on the Safety of Medicines (CSM) regarding the relative risk of ototoxicity from the use of aminoglycoside-containing drops in patients with tympanic membrane perforations. We present the findings of a survey of ENT consultants, questioning their views and current practice, and we add to the debate by means of a review and discussion of the literature.
Lancaster
J L
JL
Department of Otolaryngology, Royal Liverpool University Hospital, UK.
Makura
Z G
ZG
Porter
G
G
McCormick
M
M
D000287:Administration, Topical; D000328:Adult; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002908:Chronic Disease; D019538:Health Care Surveys; D006801:Humans; D010035:Otitis Media, Suppurative / Q000150:complications / Q000188:drug therapy*; D010818:Practice Patterns, Physicians'; D018058:Tympanic Membrane Perforation / Q000150:complications
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents