title: The impact of significant weight loss on resting energy expenditure in obese youth.
abstract: BACKGROUND
  The prevalence of obesity in American youth is increasing and treating the condition is difficult.
  
  
  METHODS
  We have developed a multidisciplinary weight-reduction program that includes a very low calorie diet followed by a hypocaloric diet, exercise, and behavior modification. Based on data collected at baseline and at the end of the acute intervention phase (10 weeks), we assessed the impact of the weight loss that resulted from participation in this weight reduction program on the resting energy expenditure and body composition of obese children and adolescents.
  
  
  RESULTS
  There was a significant decrease in body weight and body fat as assessed by weight determinations and skin-fold measurements after 10 weeks. The body mass index decreased significantly from 33.8 on entry to 29.6 (P < 0.0001). Despite the significant weight loss, resting energy expenditure and lean body mass remained constant from entry until the completion of the acute phase.
  
  
  CONCLUSIONS
  We conclude that a multidisciplinary weight-reduction program that combines a very low calorie diet followed by a balanced hypocaloric diet, with a moderate-intensity progressive exercise program and behavior modification is an effective means for weight-reduction in obese children and adolescents. Furthermore, fat mass is significantly reduced while lean body mass and resting energy expenditure are unaltered.
authors.affiliation: Department of Pediatrics, Louisiana State University School of Medicine, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Sothern
authors.forename: M
authors.initials: M
authors.lastname: Loftin
authors.forename: R M
authors.initials: RM
authors.lastname: Suskind
authors.forename: J N
authors.initials: JN
authors.lastname: Udall
authors.forename: U
authors.initials: U
authors.lastname: Blecker
mesh_terms: D000293:Adolescent; D001481:Basal Metabolism; D001521:Behavior Therapy; D001823:Body Composition; D002648:Child; D004038:Diet, Reducing; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D015431:Weight Loss / Q000502:physiology*