Association studies on beta2-adrenoceptor polymorphisms and enhanced IgE responsiveness in an atopic population.
The beta2 adrenergic receptor 2 represents a cell surface receptor responsible for the binding of endogenous catecholamines and their exogenously administered agonists and antagonists, mediating their effects to the interior of the cell. On the basis of these functions, the observed association of two of its polymorphisms, Gly16 and Gln27, with nocturnal- and steroid-dependent asthma has been discussed. It has recently been suggested that Gln27 contributes to IgE variability in families with asthma. The aim of this study was to investigate possible influences of the polymorphisms Arg16Gly and Glu27Gln on IgE levels in families recruited through an atopic index case without regard to the presence of clinical symptoms. We employed linkage analysis in affected sibpairs characterized by elevated total IgE concentrations or sensitization to common inhalant allergens. Furthermore, we tested 258 children for association of any of the polymorphisms with enhanced IgE responsiveness. We could find neither linkage at the locus 5q31 nor significant association of the polymorphisms with elevated total IgE concentrations or specific sensitization. We conclude from our data that the polymorphisms Gln27Glu and Arg16Gly of the beta2-adrenergic receptor do not play a significant role in the pathogenesis of enhanced IgE responsiveness in an atopic population in general.
Deichmann
K A
KA
University Children's Hospital, University of Freiburg, Freiburg, Germany.
Schmidt
A
A
Heinzmann
A
A
Kruse
S
S
Forster
J
J
Kuehr
J
J
D000483:Alleles; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000378:metabolism*; D007073:Immunoglobulin E / Q000378:metabolism*; D018895:Microsatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000235:genetics*
D011943:Receptors, Adrenergic, beta; D007073:Immunoglobulin E