Rifampin and rifabutin resistance mechanism in Helicobacter pylori.
Eighty-one clinical isolates of Helicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 microg/ml; MIC at which 50% of isolates are inhibited [MIC50], 0.25 microg/ml). The MIC50 of rifabutin was 0.008 microg/ml (n = 16). All resistant laboratory mutants of H. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of the rpoB gene, corresponding to the gene sequences from Mycobacterium tuberculosis and Escherichia coli.
Heep
M
M
Institut für Medizinische Mikrobiologie, Universitätsklinikum Regensburg, D-93053, Regensburg, Germany. Markus.Heep@klinik.uni-regensburg.de
Beck
D
D
Bayerdörffer
E
E
Lehn
N
N
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003062:Codon; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D017828:Rifabutin / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003062:Codon; D017828:Rifabutin; D012293:Rifampin