[Mitochondrial energy metabolism, uncoupling proteins and adipose tissue accumulation].
New possibilities are explored for supporting classical treatment of obesity. There are three main ways for the pharmacotherapy of obesity: (1) inhibition of absorption of nutrients in the intestine; (2) modulation of the activity of hypothalamic centra controlling satiety and food consumption; and (3) induction of energy dissipation in tissues (thermogenesis). The last possibility received more attention due to recent discoveries. The goal would be to affect mitochondrial energy conversion in a way leading to elevated thermogenesis and not to ATP production.
Kopecký
J
J
kopecky@biomed.cas.cz
D000255:Adenosine Triphosphate / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001833:Body Temperature Regulation; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism*; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; D000255:Adenosine Triphosphate