title: 111Indium antimyosin antibody imaging of primary myocardial involvement in systemic diseases.
abstract: OBJECTIVE
  The diagnosis of primary myocardial involvement in systemic diseases is clinically relevant but difficult in the absence of specific criteria. Whatever the underlying disease, myocytes degeneration is observed during the active phase of myocardial damage. The aim of this study was to assess the diagnostic value of scintigraphic imaging with 111Indium antimyosin antibody (AM), a specific marker of the damaged myocyte, for ongoing myocardial damage related to systemic diseases.
  
  
  METHODS
  40 patients with histologically confirmed systemic diseases were studied. They were classified into two groups according to the presence (group 1, n = 30), or the absence (group 2, n = 10) of clinical, electrocardiographic (ECG) or echocardiographic signs suggestive of myocardial involvement. Planar and tomographic acquisitions were obtained 48 hours after injection of AM (90 MBq). Rest 201thallium (T1) scintigraphy was also performed to assess myocardial perfusion and scarring. Clinical, ECG, and echocardiographic +/- scintigraphic evaluations were repeated during follow up (17 +/- 19 months) in 36 of 40 patients.
  
  
  RESULTS
  In group 1, 13 of 30 patients (43%) showed diffuse significant AM uptake throughout the left ventricle (LV), and no or mild T1 abnormality. Two of these were asymptomatic, four had normal ECG, and two had no clinical or echographic LV dysfunction. All patients in group 2 had negative AMA scintigraphy and normal T1 scintigraphy. During follow up of 12 AM positive patients, cardiac status improved after immunosuppressive treatment was intensified in nine cases, worsened in two cases, and remained stable in one. During follow up of 24 AM negative patients, cardiac status remained stable in 23 cases despite treatment not being increased in 20, including two patients with sequellary myocardial involvement. The last patient developed mild LV dysfunction after 36 months.
  
  
  CONCLUSIONS
  AM scintigraphy allows detection of active myocardial damage related to systemic diseases, with increased specificity compared with conventional methods, and increased sensitivity in some cases. Further studies are needed to assess the potential value of AM scintigraphy as a therapeutic guide.
authors.affiliation: Department of Nuclear Medicine, Hôpital Avicenne, Bobigny, France.
authors.forename: L
authors.initials: L
authors.lastname: Sarda
authors.forename: P
authors.initials: P
authors.lastname: Assayag
authors.forename: E
authors.initials: E
authors.lastname: Palazzo
authors.forename: D
authors.initials: D
authors.lastname: Vilain
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: M
authors.initials: M
authors.lastname: Faraggi
authors.forename: O
authors.initials: O
authors.lastname: Meyer
authors.forename: D
authors.initials: D
authors.lastname: Le Guludec
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies; D015415:Biomarkers; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology; D003240:Connective Tissue Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009218:Myosins / Q000276:immunology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007205:Indium Radioisotopes; D009218:Myosins