[An alternative method to determine the radiochemical purity of the 99mTC-tetrofosmine preparations].
This paper describes a new quality control method to determine the radiochemical purity (RCP) value of Technetium-99m-Tetrofosmin preparations. The results of this procedure were compared with the results obtained with the method suggested by the manufacturer of the kit (classic method), consisting in thin-layer chromatography involving the use of a single strip of ITLC/SG as the stationary phase, and a acetone:dichlorometane 35:65 (Ac:DCM) solvent mixture as the mobile phase. The method that is proposed in this paper (alternative method) uses the same stationary phase but it is developed in a single solvent, methylethylketone (MEK). This method has the following advantages: a better capacity to separate the 99mTc-Tetrofosmin complex from 99mTcO4- and 99mTcO2 impurities, a faster chromatographic developing time and the use of a single solvent in the quality control.
Gómez
J L
JL
Sección de Medicina Nuclear, Hospital Son Dureta, Palma de Mallorca, 07014, España.
Vega
F
F
Peñafiel
A
A
Daumal
J
J
Peña
C
C
Montsech
L
L
Mata
F
F
D000096:Acetone; D002074:Butanones; D002855:Chromatography, Thin Layer / Q000379:methods; D008752:Methylene Chloride; D009943:Organophosphorus Compounds / Q000032:analysis* / Q000592:standards; D015609:Organotechnetium Compounds / Q000032:analysis* / Q000592:standards; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000592:standards; D012997:Solvents
D002074:Butanones; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012997:Solvents; D000096:Acetone; D008752:Methylene Chloride; C005222:methylethyl ketone