title: Solution-phase chemical library synthesis using polymer-assisted purification techniques.
abstract: During the past few years, polymer-assisted solution-phase synthesis has become a prevalent method for the parallel synthesis of chemical libraries. This methodology allows for intermediate and final product purification by various resin-based sequestration techniques, which allow for the removal of excess reactants, by-products or side products from solution-phase reactions. The methodology has continued to expand, providing the practitioner with a broad range of ingenious purification methods, allowing single-step transformations as well as multistep syntheses to be performed in solution. The polymer-assisted solution-phase technology is currently being utilized for both the synthesis of lead generation and lead optimization libraries in the pharmaceutical arena and has also expanded into other disciplines.
authors.affiliation: Department of Combinatorial and Parallel Medicinal Chemistry, Searle Discovery Research, Monsanto Co., 800 North Lindbergh Boulevard, Saint Louis, MO 63167, USA. john.j.parlow@monsanto.com
authors.forename: J J
authors.initials: JJ
authors.lastname: Parlow
authors.forename: R V
authors.initials: RV
authors.lastname: Devraj
authors.forename: M S
authors.initials: MS
authors.lastname: South
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D009930:Organic Chemicals / Q000737:chemistry / Q000302:isolation & purification*; D011108:Polymers; D012996:Solutions
chemical_list: D009930:Organic Chemicals; D011108:Polymers; D012996:Solutions