title: Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.
abstract: Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.
authors.affiliation: Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: M R
authors.initials: MR
authors.lastname: Lewis
authors.forename: A B
authors.initials: AB
authors.lastname: Gilbert
authors.forename: M D
authors.initials: MD
authors.lastname: Noel
authors.forename: D H
authors.initials: DH
authors.lastname: Scoville
authors.forename: G W
authors.initials: GW
authors.lastname: Allman
authors.forename: P B
authors.initials: PB
authors.lastname: Savage
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D020355:Cholates / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D020355:Cholates; D011112:Polymyxin B