title: Inefficiency of the anticoagulant therapy in the regression of the radiation-induced optic neuropathy in Cushing's disease.
abstract: Radiation-induced optic neuropathy is a rare complication (prevalence less than 1%) following radiotherapy of the sellar region. However, the vasculopathy in Cushing's disease predisposes to radiation-induced injury. We report the case of a 24-year-old man with Cushing's disease since he was 16. The hormonal study including bilateral inferior petrosal sinus catheterization diagnosed a pituitary right lesion, but imagiology was always negative. He underwent a transsphenoidal microadenomectomy and the pathological study showed the presence of corticotrophic hyperplasia but no adenoma. Secondary hypothyroidism and hypogonadism as well as permanent diabetes insipidus were diagnosed and because the patient was not cured he underwent a second transsphenoidal total hypophysectomy. After that and because he was still hypercortisolemic, pituitary external irradiation was given in a total dose of 6000 rad. Six months later he developed progressive bilateral visual loss. Cerebral MR revealed focal enhancement of the enlarged optic nerves and chiasm, associated with demyelination areas of the posterior visual pathways. Treatment was tried first with high doses of corticosteroids and later with anticoagulants-heparin EV. 1000 U/h during 7 days followed by warfarin, but unsuccessfully, probably because the patient was already amaurotic at the beginning of the last treatment.
authors.affiliation: Endocrinology Department, São João Hospital and Oporto Medical School, Alameda Hernani Monteiro, Porto, Portugal.
authors.forename: A P
authors.initials: AP
authors.lastname: Barbosa
authors.forename: D
authors.initials: D
authors.lastname: Carvalho
authors.forename: L
authors.initials: L
authors.lastname: Marques
authors.forename: M
authors.initials: M
authors.lastname: Monteiro
authors.forename: A
authors.initials: A
authors.lastname: Castro Neves
authors.forename: A
authors.initials: A
authors.lastname: Machado Carvalho
authors.forename: J
authors.initials: J
authors.lastname: Cruz
authors.forename: J L
authors.initials: JL
authors.lastname: Medina
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery; D005938:Glucocorticoids / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D007016:Hypophysectomy; D007037:Hypothyroidism / Q000150:complications; D008297:Male; D009901:Optic Nerve Diseases / Q000188:drug therapy* / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D017211:Treatment Failure; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D014859:Warfarin; D006493:Heparin