[Study of transforming growth factor-alpha expression in duodenal ulcer].
Various growth factors were also reported to promote healing of peptic ulcer. We have used a monoclonal antibody in conjunction with a standard immunohistochemical technique to characterize the expression of transforming growth factor-alpha (TGF-alpha) in duodenal ulcer. TGF-alpha immunoreactivity is found in Brunner's gland, also in immature gland and in duodenal epitheliums, but not in gastric metaplasia of the duodenum. TGF-alpha expression of healing and scar stage was higher than that of active stage. The presence or absence of Helicobacter pylori infection did not affect the expression of TGF-alpha in duodenal ulcer.
Niki
S
S
Department of 4th Internal Medicine, Tokyo Medical University.
Matsubayashi
H
H
Mizoue
T
T
Mizuguchi
Y
Y
Sanada
J
J
Takei
K
K
Miwa
K
K
Horibe
T
T
Niido
T
T
Seki
T
T
Kawaguchi
M
M
Saitou
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016211:Transforming Growth Factor alpha / Q000032:analysis*
D016211:Transforming Growth Factor alpha