Vitamin E suppresses oxidative stress and glomerulosclerosis in rat remnant kidney.
Previous studies have shown that reduction of renal mass in the rat remnant kidney model induces overproduction of transforming growth factor beta1 (TGFbeta1). We investigated whether an antioxidant, vitamin E, administered before the renal mass reduction, could prevent oxidative stress, reduce the overproduction of TGFbeta1, and mitigate against the subsequent glomerulosclerosis. Our results revealed that the oxidative stress, as measured by the change in plasma malondialdehyde, is significantly reduced by prior vitamin E dietary supplementation. Finally, our data show that dietary vitamin E supplementation ameliorates the rise in TGFbeta1 secondary to renal mass reduction and inhibits the glomerular sclerosis of the remnant kidney over the time course of this experiment.
Hahn
S
S
Department of Pediatrics, Catholic University Medical College, Seoul, Korea.
Krieg
R J
RJ
Hisano
S
S
Chan
W
W
Kuemmerle
N B
NB
Saborio
P
P
Chan
J C
JC
D000818:Animals; D003404:Creatinine / Q000097:blood; D005527:Food, Fortified; D005921:Glomerulonephritis / Q000473:pathology / Q000517:prevention & control*; D007672:Kidney Cortex / Q000378:metabolism; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D009392:Nephrectomy; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D014810:Vitamin E; D008315:Malondialdehyde; D003404:Creatinine