title: The effects of pyruvate supplementation on body composition in overweight individuals.
abstract: A 6-wk, double-blinded, placebo-controlled study was done to ascertain the effects of pyruvate supplementation (6 g/d) on body weight, body composition, and vigor and fatigue levels in healthy overweight Caucasian men and women. Twenty-six individuals were randomly assigned to a placebo group (seven men, seven women) and a pyruvate-supplemented group (three men, nine women). In addition, all subjects participated in a 3 d/wk exercise program, which consisted of a 45-60 min aerobic/anaerobic routine. After 6 wk of treatment, there was a statistically significant decrease in body weight (-1.2 kg, P<0.001), body fat (-2.5 kg, P<0.001), and percent body fat (23.0% pre versus 20.3% 6 wk post) in the pyruvate group. Furthermore, Profile of Mood States fatigue and vigor scores improved significantly for the pyruvate group (P<0.05) at 6 wk (vigor) and 4 and 6 wk (fatigue). There was no significant change in total lean body mass in the pyruvate group. The placebo group demonstrated a significant increase (P<0.05) for POMS vigor at 2 and 4 wk with no changes occurring in any of the remaining parameters measured. Thus, the ingestion of 6 g of pyruvate for 6 wk, in conjunction with mild physical activity, resulted in a significant decrease in body weight and fat mass.
authors.affiliation: Peak Wellness, Greenwich, Connecticut 06830, USA.
authors.forename: D
authors.initials: D
authors.lastname: Kalman
authors.forename: C M
authors.initials: CM
authors.lastname: Colker
authors.forename: I
authors.initials: I
authors.lastname: Wilets
authors.forename: J B
authors.initials: JB
authors.lastname: Roufs
authors.forename: J
authors.initials: J
authors.lastname: Antonio
mesh_terms: D000328:Adult; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D019289:Pyruvic Acid / Q000008:administration & dosage*
chemical_list: D010919:Placebos; D019289:Pyruvic Acid