title: Suppressive effect of anticardiolipin antibody on the proliferation of human umbilical vein endothelial cells.
abstract: OBJECTIVE
  To determine whether sera that show a positive anticardiolipin test result have a suppressive effect on the proliferation of endothelial cells collected from human umbilical veins.
  
  
  METHODS
  Retrospective in vitro study.
  
  
  METHODS
  University hospital outpatient clinic for the treatment of infertility.
  
  
  METHODS
  Thirteen patients with recurrent fetal miscarriages who were positive for anticardiolipin antibody and 14 patients with recurrent miscarriages who were negative for anticardiolipin antibody.
  
  
  METHODS
  Serum was obtained from each patient.
  
  
  METHODS
  Suppressive effect of the sera on the culture of human umbilical vein endothelial cells.
  
  
  RESULTS
  The proliferation of human umbilical vein endothelial cells decreased significantly in cultures that contained sera showing positive anticardiolipin antibody activity that had been collected from patients with recurrent fetal miscarriages.
  
  
  CONCLUSIONS
  The results strongly suggest that anticardiolipin antibody has a suppressive effect on the proliferation of human umbilical vein endothelial cells.
authors.affiliation: Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Arakawa
authors.forename: K
authors.initials: K
authors.lastname: Takakuwa
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Kurabayashi
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000494:pharmacology*; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D014471:Umbilical Veins / Q000166:cytology*
chemical_list: D017153:Antibodies, Anticardiolipin; D004247:DNA