title: Analysis of deformations in 26,810 consecutive infants with congenital defects.
abstract: Here we present the analysis of deformations observed in a series of 26,810 consecutive infants with congenital defects. We observed that 3.88% of these infants had deformations, for a prevalence figure of 0.07% live-born infants. From the present study we can conclude that there are three different types of deformation sequences: one with polyhydramnios, thin skin without dermal ridges, hypotonia, and multiple deformations (hypokinesia sequence), which is most often due to intrinsic problems; another with oligohydramnios, redundant thick skin, and multiple deformations, which can be produced by intrinsic or extrinsic factors; and the third, with normal amniotic fluid volume, which is due to compression of different causes. Deformations of extrinsic cause are more frequently isolated defects and have a better prognosis, while deformations of intrinsic origin are more frequently associated with other congenital anomalies and, generally, have a poor prognosis.
authors.affiliation: ECEMC and Department of Pharmacology, Universidad Complutense, Madrid, Spain. luisama@eucmos.sim.ucm.es
authors.forename: M L
authors.initials: ML
authors.lastname: Martínez-Frías
authors.forename: E
authors.initials: E
authors.lastname: Bermejo
authors.forename: J L
authors.initials: JL
authors.lastname: Frías
mesh_terms: D000013:Congenital Abnormalities / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D015995:Prevalence; D013030:Spain / Q000453:epidemiology