A feasibility evaluation of an automated blood component collection system platelets and red cells.
BACKGROUND
The purpose of these studies was to evaluate the functional properties of blood components collected with an automated collection system.


METHODS
Single-donor platelets (n = 44) and packed red cell (RBC) units (n = 10) were collected. In vitro and in vivo assays were used to assess the function of single-donor platelet components stored for 5 days and of packed RBC units after storage for 42 days at 4 degrees C.


RESULTS
Adverse events observed in the 44 study subjects were minor. The mean 24-hour recovery value for the packed RBC units stored for 42 days was 83.6 +/- 5.4 percent, with a mean percentage of hemolysis on Day 42 at 0.46 +/- 0.19 percent. The 25 patients receiving platelet components achieved a mean corrected count increment of 15.1 +/- 10.4 x 10(3). All platelet concentrates had less than 1 x 10(6) total white cells.


CONCLUSIONS
Both in vitro and in vivo testing for the packed RBCs collected and stored for 42 days met the standards for both hemolysis and percentage of 51Cr 24-hour RBC recovery. The in vitro results and transfusion data on white cell-reduced platelet components transfused to thrombocytopenic patients were comparable to those on available platelet components.
Rugg
N
N
Hoxworth Blood Center, Cincinnati, Ohio, USA.
Pitman
C
C
Menitove
J E
JE
Greenwalt
T J
TJ
McAteer
M J
MJ
D001331:Automation; D001800:Blood Specimen Collection / Q000379:methods*; D004912:Erythrocytes; D005069:Evaluation Studies as Topic; D005240:Feasibility Studies; D006801:Humans; D010983:Plateletpheresis; D013921:Thrombocytopenia / Q000628:therapy; D014182:Transplantation, Autologous