Antiviral properties of a crude extract from a green alga Caulerpa taxifolia (Vahl) C. Agardh.
A crude extract of Caulerpa taxifolia was tested for its antiviral activity. The chloroform-methanol residue showed an interesting inhibitor effect in vitro toward the feline immunodeficiency virus (FIV), a valid model for studying the acquired immunodeficiency syndrome. This extract reduced the virus-induced syncytia in the cultured cells, the viral reverse transcriptase activity and the viral capsid protein P24 expression.
Nicoletti
E
E
Dipartimento di Biomedicina, Centro Retrovirus sezione di Virologia, Università degli Studi di Pisa, Italy.
Della Pietà
F
F
Calderone
V
V
Bandecchi
P
P
Pistello
M
M
Morelli
I
I
Cinelli
F
F
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002415:Cats; D002460:Cell Line; D000460:Chlorophyta / Q000737:chemistry*; D015683:Gene Products, gag / Q000378:metabolism; D015726:Giant Cells / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D010936:Plant Extracts / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
D000998:Antiviral Agents; D015683:Gene Products, gag; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors; C074662:p24 protein, Feline immunodeficiency virus