Alpha, beta-unsaturated aldehydes mediate inducible expression of glutathione S-transferase in hepatoma cells through activation of the antioxidant response element (ARE).
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Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, USA.
Luckey
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Kroll
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Petersen
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DR
D000171:Acrolein / Q000378:metabolism / Q000494:pharmacology; D000447:Aldehydes / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D005982:Glutathione Transferase / Q000096:biosynthesis / Q000235:genetics*; D007527:Isoenzymes; D008969:Molecular Sequence Data; D051381:Rats; D020218:Response Elements; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D000975:Antioxidants; D007527:Isoenzymes; C051750:2-hexenal; D000171:Acrolein; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha; C041116:leukotriene-C4 synthase; C027576:4-hydroxy-2-nonenal