title: Reactions causing reactions: allergic contact dermatitis to an isocyanate metabolite but not to the parent compound.
abstract: Industrial use of isocyanate resins rarely causes allergic contact dermatitis. We report a patient who developed allergic contact dermatitis to a transitory chemical breakdown product of the isocyanate 4,4'-diphenylmethane diisocyanate (MDI), diaminodiphenylmethane (DDM), although he was not sensitized to the suspected parent compound MDI.
authors.affiliation: Department of Dermatology, Fremantle Hospital, Australia.
authors.forename: C P
authors.initials: CP
authors.lastname: Tait
authors.forename: T A
authors.initials: TA
authors.lastname: Delaney
mesh_terms: D000328:Adult; D000485:Allergens; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D012882:Skin Tests; D001559:Benzhydryl Compounds
chemical_list: D000485:Allergens; D017953:Isocyanates; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds