title: Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins.
abstract: Ginseng sapogenins were produced from ginseng saponins, isolated from Korean ginseng roots. Ginseng saponins very mildly inhibited acyl-CoA:cholesterol acyltransferase (ACAT) in vitro, however, the sapogenins showed strong inhibitory activity on microsomal ACAT. Therefore, the sapogenins will be one of key ingredients of ginseng affected a lowering of the serum total cholesterol level.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon.
authors.forename: B M
authors.initials: BM
authors.lastname: Kwon
authors.forename: M K
authors.initials: MK
authors.lastname: Kim
authors.forename: N I
authors.initials: NI
authors.lastname: Baek
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: J D
authors.initials: JD
authors.lastname: Park
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D051381:Rats; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012503:Saponins / Q000737:chemistry*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
chemical_list: D000924:Anticholesteremic Agents; D004791:Enzyme Inhibitors; D012502:Sapogenins; D012503:Saponins; D002785:Sterol O-Acyltransferase