A novel fungal metabolite NG-061 enhances and mimics neurotrophic effect of nerve growth factor (NGF) on neurite outgrowth in PC12 cells.
During the course of our screening program for low molecular natural products with their ability to potentiate and/or mimic neurotrophic effect of NGF, a novel fungal metabolite, phenylacetic acid hydrazide derivative NG-061 was isolated from the fermentation broth of Penicillium minioluteum F-4627. NG-061 enhanced and mimicked neurotrophic effect of NGF on neurite outgrowth in a rat pheochromocytoma cell line PC12.
Ito
M
M
Research Laboratories, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Sakai
N
N
Ito
K
K
Mizobe
F
F
Hanada
K
K
Mizoue
K
K
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004357:Drug Synergism; D005285:Fermentation; D006834:Hydrazines / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D016716:PC12 Cells; D010407:Penicillium / Q000145:classification / Q000378:metabolism; D010648:Phenylacetates / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D006834:Hydrazines; C119398:NG 061; D009414:Nerve Growth Factors; D010648:Phenylacetates