Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin.
The mechanism of the positive cardioactive effects induced by verbascoside in the Lagendorff rat heart has been investigated. Isolated rat hearts treated with alpha- or beta-adrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside. A significant increase in prostacyclin levels (142%) observed following the administration of verbascoside suggests that prostacyclin stimulates formation of cAMP which induces the cardioactivity associated with verbascoside.
Pennacchio
M
M
School of Environmental Biology, Curtin University of Technology, Perth, Western Australia, Australia.
Syah
Y M
YM
Alexander
E
E
Ghisalberti
E L
EL
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology*; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D005960:Glucosides / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010636:Phenols; D051381:Rats; D017208:Rats, Wistar; D059808:Polyphenols
D002317:Cardiovascular Agents; D011464:Epoprostenol; D005960:Glucosides; D010636:Phenols; C058956:acteoside; D059808:Polyphenols