Therapeutic values of different routes of administration of vitamin A with ferrous sulfate in treating deferoxamin-induced iron-deficiency anemia.
About half the pregnant women in developing countries suffer from iron-deficiency anemia. The treatment of choice for these patients includes iron compounds such as ferrous sulfate. It was recently shown that a concomitant administration of vitamin A with ferrous sulfate increases iron-induced hematopoietic effect. In the current study, the efficacy of various routes of administration of vitamin A with ferrous sulfate in deferoxamin-treated anemic rats were compared. The work reveals no difference among various routes of administration, including several alternates of oral and intramuscular injection of vitamin A and ferrous sulfate for 28 d. It was therefore concluded that the therapeutic effect of vitamin A in iron-deficiency anemia is probably not via its influence on iron absorption from the gastrointestinal tract.
Sajedianfard
J
J
Department of Pharmacology, School of Veterinary Medicine, Shiraz University, Iran. sajedian@hafez.shirazu.ac.ir
Boroujeni
H M
HM
Habibzadeh
F
F
D000284:Administration, Oral; D018798:Anemia, Iron-Deficiency / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D003676:Deferoxamine; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000008:administration & dosage*
D005296:Ferrous Compounds; D014801:Vitamin A; C020748:ferrous sulfate; D003676:Deferoxamine