title: Comparison of iodixanol 270 with iohexol 300 in infrapopliteal arteriography. Digital densitometric analysis of angiographic opacification.
abstract: OBJECTIVE
  To compare iodixanol 270 mg I/ml with iohexol 300 mg I/ml in infrapopliteal arteriography by measuring digital densitometric vessel opacification and by visually assessing angiographic enhancement.
  
  
  METHODS
  In a double-blind, dual-balanced, 4-sequence cross-over design, 50 claudicant patients received two contrast media injections (10 min interval) in the superficial femoral artery. Digital angiography was performed at 8 frames/s and time-density curves with a circular region of interest over a distal calf artery were generated. A mixed, linear model was used to identify effects influencing the density measurements. Subjective evaluation of the image quality was made independently by two observers.
  
  
  RESULTS
  No statistically significant difference between the contrast media was revealed in the analysis of the densitometric measurements (p=0.14) nor in the subjective visual evaluation (p=0.74). However, the mean density at the time of maximum opacification was higher after the first injection than that after the second injection (p=0.02). There was a tendency towards lower intensity of warmth during injection of iodixanol 270 than during injection of iohexol 300.
  
  
  CONCLUSIONS
  In patients with severe occlusive atherosclerotic disease, iodixanol yielded the same image quality as iohexol in infrapopliteal arteriography, in spite of the 30 mg I/ml lower iodine concentration.
authors.affiliation: Department of Clinical Radiology, Kuopio University Hospital, Finland.
authors.forename: H I
authors.initials: HI
authors.lastname: Manninen
authors.forename: X M
authors.initials: XM
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Söder
authors.forename: P J
authors.initials: PJ
authors.lastname: Matsi
authors.forename: K W
authors.initials: KW
authors.lastname: Borch
authors.forename: H
authors.initials: H
authors.lastname: Eide
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D003287:Contrast Media; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000000981:diagnostic imaging; D007472:Iohexol; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D014283:Triiodobenzoic Acids
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C044834:iodixanol