title: Bisphosphonates as cancer drugs.
abstract: Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.
authors.affiliation: Division of Endocrinology and Metabolism, University of Texas Health Science Center at San Antonio, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Mundy
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004002:Clodronic Acid / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010014:Osteolysis / Q000188:drug therapy*; D000077268:Pamidronate; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology; D000068296:Risedronic Acid; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D016212:Transforming Growth Factor beta; D004002:Clodronic Acid; D000068296:Risedronic Acid; D012968:Etidronic Acid; D000077268:Pamidronate