Comparison of the half-lives and regeneration rates of blood clotting factors II, VII, and X in anticoagulant-resistant and susceptible Norway rats (Rattus norvegicus Berk.).
The half-lives and regeneration rates of clotting factors II, VII, and X in the plasma of anticoagulant-resistant and susceptible rats were determined. There is little or no difference in the half-lives of factors II and X in anticoagulant-resistant rats compared to susceptible rats, but the half-life of factor VII is longer in anticoagulant-resistant rats. In anticoagulant-resistant rats critical clotting factors appear to be carboxylated in preference to factor II, whereas the opposite occurs in susceptible rats; this may contribute to an animal's resistance status.
Kerins
G M
GM
Central Science Laboratory, Ministry of Agriculture, Fisheries and Food, Sand Hutton, York, UK. g.kerins@csl.gov.uk
MacNicoll
A D
AD
D000818:Animals; D000925:Anticoagulants; D005167:Factor VII / Q000096:biosynthesis / Q000378:metabolism*; D005170:Factor X / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008297:Male; D011516:Prothrombin / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012378:Rodenticides
D000925:Anticoagulants; D012378:Rodenticides; D005167:Factor VII; D011516:Prothrombin; D005170:Factor X