title: Molecular characterization and phylogenetic analysis of SpBMP5-7, a new member of the TGF-beta superfamily expressed in sea urchin embryos.
abstract: TGF-beta ligands are probably pan-bilaterian in phylogenetic distribution. The family appears to have diversified greatly with the evolution of the vertebrates, but only a few invertebrate deuterostome TGF-beta molecules have so far been isolated. A search for members of this family expressed in sea urchin embryos, using canonical PCR primers, revealed a single-copy gene encoding a new TGF-beta protein. The sequence which it encodes is closely related to those of vertebrate bone morphogenetic proteins (BMPs) 5-7. No additional TGF-beta family members were uncovered other than univin, which had previously been reported.
authors.affiliation: División de Genética, Universidad Miguel Hernández, Alicante, Spain.
authors.forename: M R
authors.initials: MR
authors.lastname: Ponce
authors.forename: J L
authors.initials: JL
authors.lastname: Micol
authors.forename: K J
authors.initials: KJ
authors.lastname: Peterson
authors.forename: E H
authors.initials: EH
authors.lastname: Davidson
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D055417:Bone Morphogenetic Protein 5; D055418:Bone Morphogenetic Protein 6; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004625:Embryo, Nonmammalian / Q000378:metabolism; D018628:Gene Dosage; D008969:Molecular Sequence Data; D010802:Phylogeny; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000378:metabolism
chemical_list: D055417:Bone Morphogenetic Protein 5; D055418:Bone Morphogenetic Protein 6; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta