title: Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
abstract: Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: S U
authors.initials: SU
authors.lastname: Kang
authors.forename: M K
authors.initials: MK
authors.lastname: Kang
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jo
authors.forename: J H
authors.initials: JH
authors.lastname: Kwak
authors.forename: S
authors.initials: S
authors.lastname: Kim
mesh_terms: D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D008715:Methionine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008718:Methionine-tRNA Ligase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; C011501:methioninyl adenylate; D000249:Adenosine Monophosphate; D008715:Methionine; D008718:Methionine-tRNA Ligase