How to extinguish lymphocyte activation, immunotyrosine-based inhibition motif (ITIM)-bearing molecules a solution?
ITIM-bearing molecules represent a novel family of inhibitory receptors expressed widely through the hematopoietic compartment. These molecules share certain features such as the presence in their intracytoplasmic domain of the so-called motif ITIM (ImmunoTyrosine-based Inhibition Motif). These molecules are able to recruit phosphatases on their phosphorylated ITIM and thus mediate a localized inhibition of the transduction pathways. The molecular basis of this inhibitory pathway is discussed below.
Blery
M
M
Centre d'Immunologie de Marseille-Luminy, Marseille, France. blery@ciml.univ.mrs.fr
Vivier
E
E
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry / Q000378:metabolism*; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D008213:Lymphocyte Activation; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D007136:Immunoglobulins; D037102:Lectins; D011971:Receptors, Immunologic; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases