IFN alpha kinoid vaccine in conjunction with tritherapy, a weapon to combat immunopathogenesis in AIDS.
Antiviral therapy, including antiprotease treatment, suppresses viral replication, but it does not restore the HIV-1 induced immunopathogenesis which includes IFN alpha overproduction and cellular immunosuppression. To combat HIV-1 induced immunopathogenesis, anti-IFN alpha kinoid immunization in combination with tritherapy may be beneficial to HIV-1 infected immunodeficient patients.
Bizzini
B
B
Laboratoire de Physiologie Cellulaire, Université Pierre et Marie Curie, Paris, France.
Volpato
I
I
Lachgar
A
A
Cohen
P
P
Gringeri
A
A
D016915:AIDS Vaccines / Q000627:therapeutic use; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D004359:Drug Therapy, Combination; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology*; D014612:Vaccines / Q000627:therapeutic use*
D016915:AIDS Vaccines; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D001323:Autoantibodies; D016898:Interferon-alpha; D014612:Vaccines