Aplastic anemia responsive to cyclosporine complicating the evolution of polycythemia vera.
We report here a very unusual patient with Polycythemia vera treated with Pipobroman who developed severe aplastic anemia following administration of the drug. Six months later, because of lack of response, cyclosporine therapy was given there was rapid and complete hematological recovery, highly suggestive of an immune-mediated mechanism, in this case.
Bouscary
D
D
Service d'Hématologie, Hôpital Cochin, Paris, France.
Jondeau
K
K
Viguié
F
F
Zompi
S
S
Fontenay-Roupie
M
M
Quarre
M C
MC
Vassilief
D
D
Dreyfus
F
F
Casadevall
N
N
D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000188:drug therapy*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010885:Pipobroman / Q000009:adverse effects* / Q000627:therapeutic use; D011087:Polycythemia Vera / Q000188:drug therapy*
D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D010885:Pipobroman; D016572:Cyclosporine