A cyclitol derivative as a replication inhibitor from the marine sponge Petrosia sp.
A bioactive cyclitol derivative (1) was isolated from the marine sponge Petrosia sp. The chemical structure of 1 was determined as (2S)-1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10' '-methylhexadecyl)glycerol. Compound 1 inhibited DNA replication in vitro at the level of initiation.
Kim
D K
DK
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Lim
Y J
YJ
Kim
J S
JS
Park
J H
JH
Kim
N D
ND
Im
K S
KS
Hong
J
J
Jung
J H
JH
D000818:Animals; D004261:DNA Replication / Q000187:drug effects*; D004279:DNA, Viral / Q000378:metabolism; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019384:Nucleic Acid Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013539:Simian virus 40 / Q000378:metabolism; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013402:Sugar Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059004:Topoisomerase I Inhibitors
C120215:1-O-(2',3',4',5'-tetrahydroxycyclopentyl)-3-O-(10''-methylhexadecyl)glycerol; D004279:DNA, Viral; D019384:Nucleic Acid Synthesis Inhibitors; D013402:Sugar Alcohols; D059004:Topoisomerase I Inhibitors; D005990:Glycerol