title: Autologous stem cell transplantation for multiple myeloma: a single centre experience.
abstract: Thirty-two patients with multiple myeloma (MM) were autografted in our Centre over a 3-year period. Twenty-three patients had a newly diagnosed MM submitted to one induction regimen and 9 had a refractory or relapsing disease treated with at least two different chemotherapy lines: 15 out of 32 patients were sensitive to conventional treatment. In 2 patients BM was harvested while in the majority PBSC were collected after administration of 7 g/m2 Cyclophosphamide plus G-CSF (in 25 patients) or G-CSF alone at the dose of 16 microg/Kg/daily for 5-7 days (in 5 patients). Conditioning regimen was busulfan 16 mg/Kg plus melphalan 120 mg/m2. One patient died of cerebral hemorrhage after reinfusion of PBSC. Out of 31 evaluable patients, 24 (77%) had a response which was complete in 6 patients (19%) and partial in 18 patients (58%), 5 cases (17%) had no response, and 2 (6%) showed myeloma progression. There was a statistical difference in the outcome between newly diagnosed and pretreated patients (p = 0.003). At a median follow-up of 9 months (range 5-37), two patients had died for progression and 3 out of the 29 alive, relapsed after 17, 18 and 36 months respectively. Although median overall survival was not reached, there was a significant survival benefit for autografted patients in comparison with a matched control group conventionally treated in our Centre before 1994 (p = 0.02).
authors.affiliation: Division of Hematology, University of Udine, Udine, 33100, Italy.
authors.initials: F
authors.lastname: Patriarca
authors.initials: R
authors.lastname: Fanin
authors.initials: F
authors.lastname: Silvestri
authors.initials: D
authors.lastname: Damiani
authors.initials: S
authors.lastname: Grimaz
authors.initials: L
authors.lastname: Infanti
authors.initials: A
authors.lastname: Sperotto
authors.initials: R
authors.lastname: Stocchi
authors.initials: M
authors.lastname: Cerno
authors.initials: A
authors.lastname: Geromin
authors.initials: C
authors.lastname: Savignano
authors.initials: C
authors.lastname: Rinaldi
authors.initials: F
authors.lastname: Biffoni
authors.initials: M
authors.lastname: Baccarani