The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication.
The protein kinase catalytic core in essence comprises an extended network of interactions that link distal parts of the molecule to the active site where they facilitate phosphoryl transfer from ATP to protein substrate. This review defines key sequence and structural elements, describes what is currently known about the molecular interactions, and how they are involved in catalysis.
Smith
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CM
San Diego Supercomputer Center, University of California, La Jolla 92093-0505, USA. csmith@sdsc.edu
Radzio-Andzelm
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E
Madhusudan
Akamine
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P
Taylor
S S
SS
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D020134:Catalytic Domain; D016384:Consensus Sequence; D017868:Cyclic AMP-Dependent Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D046911:Macromolecular Substances; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary
D046911:Macromolecular Substances; D017868:Cyclic AMP-Dependent Protein Kinases