Respiratory distress due to minocycline-induced pulmonary lupus.
Minoeycline, a semisynthetic tetracycline, is often used to treat acne and rheumatoid arthritis. It has been considered an unlikely drug to be associated with systemic lupus erythematosus; however, many cases of drug-induced lupus related to minocycline have been reported. Some of those reports included pulmonary lupus, but none of the patients described developed respiratory distress. We describe a patient treated with minocycline for 2 years who presented with progressive dyspnea, severe hypoxia, and pulmonary infiltrates necessitating hospitalization and oxygen supplementation.
Christodoulou
C S
CS
Department of Pediatrics, University of South Florida/All Children's Hospital, St. Petersburg 33701, USA.
Emmanuel
P
P
Ray
R A
RA
Good
R A
RA
Schnapf
B M
BM
Cawkwell
G D
GD
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008911:Minocycline / Q000009:adverse effects*; D011859:Radiography; D012131:Respiratory Insufficiency / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D008911:Minocycline