[Carotid atherosclerosis and thrombotic stroke. Diagnostic and therapeutic perspectives].
Carotid atherosclerotic lesions can be studied with color-Doppler ultrasonography vascular systems. Ultrasonography of the carotid plaques at major risk for the development of cerebrovascular ischemic events showed the following characteristics: irregular surface, degree of stenosis > 70%, intimal hemorrhage and ulceration. The plaques with these ultrasonography patterns have to be considered for surgical approach (TEA). The other patients with carotid atherosclerotic lesions will be initially treated with diet and changes of life style to obtain the correction of cardiovascular risk factors (i.e. hypertension, hypercholesterolemia, diabetes). Furthermore, medical therapy with antithrombotic agents will be instituted which, used with good results also in acute cerebral stroke, proved to be effective in the reduction of vascular events in patients with extracranial atherosclerotic plaques. However, it has not been clarified if the positive effect of antiaggregation therapy in carotid atherosclerosis is due to the inhibition of the progression and plaque growth or if other hemorheological factors are involved.
Oliviero
U
U
Cattedra di Medicina Interna, Università degli Studi Federico II, Napoli.
Iasiuolo
L
L
La Pastina
G
G
Conturso
V
V
Bonè
F
F
Riccio
G
G
Fazio
S
S
D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000601:surgery; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D002561:Cerebrovascular Disorders / Q000209:etiology*; D006801:Humans; D013927:Thrombosis / Q000150:complications; D018615:Ultrasonography, Doppler, Color