Bowen's disease showing spontaneous complete regression associated with apoptosis.
Spontaneous regression is sometimes seen in malignant skin tumours. We report a 68-year-old woman whose Bowen's disease showed spontaneous complete regression. Prominent infiltration of T cells and increased vascularity were found in the upper dermis of the regressed lesion. Strong expression of Fas (APO-1/CD95) antigen, an apoptosis-related tumour necrosis factor receptor family protein, in the primary lesion and faint expression following regression suggest the involvement of Fas-mediated apoptosis in the spontaneous complete regression of our patient's Bowen's disease.
Chisiki
M
M
Department of Dermatology, National Defense Medical College, Namiki 3-2, Tokorozawa, Saitama 359-0042, Japan.
Kawada
A
A
Akiyama
M
M
Itoh
Y
Y
Tajima
S
S
Ishibashi
A
A
Yudate
F
F
D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis; D001913:Bowen's Disease / Q000473:pathology*; D002462:Cell Membrane / Q000276:immunology; D004817:Epidermis / Q000276:immunology; D005260:Female; D006801:Humans; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology*; D019014:fas Receptor / Q000032:analysis
D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen; D019014:fas Receptor