An improved method for the measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry.
An improved method for the quantitative measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives.
Leis
H J
HJ
University Childrens Hospital, Dept. of Biochemical Analysis and Mass Spectrometry, University of Graz, Austria.
Fauler
G
G
Raspotnig
G
G
Windischhofer
W
W
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D017706:Lisinopril / Q000097:blood* / Q000493:pharmacokinetics
D000806:Angiotensin-Converting Enzyme Inhibitors; D007202:Indicators and Reagents; D017706:Lisinopril