[Predictive molecular diagnosis and preventive surgical treatment of hereditary colorectal carcinoma: a new field of interest for surgical research].
Colorectal cancer is one of the most frequent cancers in the Western hemisphere. It seems to be well established that colorectal tumors develop as a result of an accumulation of inherited and/or acquired somatic mutational events in tumor suppressor genes and oncogenes. An increasing understanding of the molecular basis of the most prevalent colorectal cancer syndromes, such as hereditary nonpolyposis colorectal cancer (HNPCC) and familial adenomatous polyposis (FAP), is reflected by modifications in diagnosis and therapy. Therefore, strategies have been developed for predictive molecular diagnosis and preventive surgical treatment of colorectal cancer syndromes. In the future surgical research will participate in research and development in the field of molecular diagnosis of colorectal cancer and will then evaluate the clinical management concepts as a result.
Hahn
M
M
Abteilung Chirurgische Forschung, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Kruppa
C
C
Pistorius
S
S
Schackert
H K
HK
D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000601:surgery; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000503:physiopathology / Q000601:surgery*; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D009857:Oncogenes / Q000502:physiology