title: Clinical experience with 111 thoratec ventricular assist devices.
abstract: BACKGROUND
  Ventricular assist devices (VADs) have gained wider acceptance due to refinements in patient selection and management and device availability.
  
  
  METHODS
  To evaluate early and late results, we reviewed our first 111 patients with the Thoratec VAD.
  
  
  RESULTS
  Forty-four patients were supported for myocardial recovery. The mean age in the recovery group was 51.9 years. There were 18 left VADs (LVADs), 17 biventricular VADs (BVADs), and nine right VADs (RVADs). Complications included bleeding in 20 patients (45%) and device-related infection in 1 patient (2%). Nineteen were weaned from the VAD, with 12 survivors. Sixty-seven patients were supported as a bridge to cardiac transplantation. The mean age was 41.5 years. There were 39 LVADs and 28 BVADs. Complications included bleeding in 21 patients (31%) and device-related infection in 12 (18%). Three patients were weaned and 39 patients were transplanted from the assist device, for a total of 42 bridge survivors. Device-related thromboembolism occurred in 9 patients (8.1%), 7 of whom were bridge to transplantation. The duration of VAD support ranged from 0.1 to 27 days (mean 4.5 days) in the recovery group and 0.2 to 184 days (mean 40.7 days) in the bridge to transplantation group. The 10-year actuarial survival was 16% for the recovery group, 22%, for the bridge group, and 33% for transplanted patients.
  
  
  CONCLUSIONS
  Despite advances, VAD support remains associated with significant morbidity and operative mortality.
authors.affiliation: Department of Surgery, Saint Louis University, Missouri 63110-0250, USA. mcbridlr@wpogate.slu.edu
authors.forename: L R
authors.initials: LR
authors.lastname: McBride
authors.forename: K S
authors.initials: KS
authors.lastname: Naunheim
authors.forename: A C
authors.initials: AC
authors.lastname: Fiore
authors.forename: D A
authors.initials: DA
authors.lastname: Moroney
authors.forename: M T
authors.initials: MT
authors.lastname: Swartz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy; D011183:Postoperative Complications; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome