title: Doppler spectral waveform analysis of arteries of the hand in patients with Raynaud's phenomenon as compared with healthy subjects.
abstract: OBJECTIVE
  We sought to characterize and compare the blood flow patterns of peripheral arteries of the hand in patients with Raynaud's phenomenon and in healthy subjects.
  
  
  METHODS
  We used Doppler sonography to assess the blood flow pattern of the proper palmar digital artery and the deep radial arch in the hands of 79 healthy subjects and 24 patients with primary and secondary Raynaud's phenomenon. We determined the resistive index, pulsatility index, peak systolic velocity, and end-diastolic velocity of these peripheral arteries at rest and after cold immersion.
  
  
  RESULTS
  The proper palmar digital artery of healthy subjects showed higher end-diastolic velocities and lower resistive indexes than did the deep radial arch. Compared with healthy subjects, patients with Raynaud's phenomenon had higher resistive and pulsatility indexes but lower peak systolic and end-diastolic velocities in these arteries. Accordingly, the differences in end-diastolic velocity and resistive index seen in the two peripheral arteries of healthy subjects were not seen in patients with Raynaud's phenomenon. Analysis of receiver operating characteristic curves showed high diagnostic accuracy in detecting the disease. Cold-immersion studies revealed that for the proper palmar digital arteries throughout the time after immersion, all these Doppler parameters were significantly lower for the velocities and higher for the indexes in patients with Raynaud's phenomenon than in healthy subjects.
  
  
  CONCLUSIONS
  Taken together, these results suggest a legitimate role for Doppler sonography in the assessment of Raynaud's phenomenon.
authors.affiliation: Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Chikui
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawabe
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000000981:diagnostic imaging; D003080:Cold Temperature; D005260:Female; D006225:Hand / Q000098:blood supply* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000000981:diagnostic imaging*; D012016:Reference Values; D012039:Regional Blood Flow; D018709:Statistics, Nonparametric; D013997:Time Factors; D018608:Ultrasonography, Doppler / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data