title: Effects of increasing balloon pressure on mechanism and results of balloon angioplasty for treatment of restenosis after Palmaz-Schatz stent implantation: an angiographic and intravascular ultrasound study.
abstract: Repeat balloon angioplasty is a widely used therapeutic option for in-stent restenosis, but the optimal balloon inflation pressure has not yet been determined. We used angiography and intravascular ultrasound imaging to assess the mechanism and results of lumen enlargement at various inflation pressures. Thirteen consecutive patients with restenosis post-Palmaz-Schatz stent implantation were submitted to a four-step balloon angioplasty using increasing balloon pressure of 2, 4, 8, and >12 atm. As a global result, the lumen size was only 80% of that observed at stent implantation. Significant changes in angiographic minimal lumen diameter, minimal lumen cross-sectional area, and lumen volume were observed after each step except after the highest-pressure inflation. At low inflation pressure (<8 atm), the decrease in neointimal tissue and the stent over expansion explained the lumen enlargement, whereas after further high inflation pressure (>8 atm), only additional stent over expansion was observed. These results suggest that only moderate balloon inflation pressure (up to 12 atm) is needed for angioplasty of post-Palmaz-Schatz stent restenotic lesions.
authors.affiliation: Hôpital Saint-Jacques, Besançon, France. jean-pierre.bassand@ufc-chu.univ-fcomte.fr
authors.forename: F
authors.initials: F
authors.lastname: Schiele
authors.forename: A
authors.initials: A
authors.lastname: Vuillemenot
authors.forename: N
authors.initials: N
authors.lastname: Meneveau
authors.forename: D
authors.initials: D
authors.lastname: Pales-Espinosa
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: J P
authors.initials: JP
authors.lastname: Bassand
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011312:Pressure; D012008:Recurrence; D015607:Stents; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional