Carbamazepine-induced hepatorenal failure in a child.
Carbamazepine is used to manage generalized tonic-clonic, partial, and mixed partial and generalized seizure disorders in children. It is frequently associated with neurologic adverse events, Stevens-Johnson syndrome, and hematologic side effects. Hepatic and renal adverse effects are less common but can cause death. A 6-year-old boy receiving carbamazepine for partial seizure disorder developed hepatorenal failure. With discontinuation of the drug, his liver and kidney function returned to normal within 2 weeks.
Haase
M R
MR
Department of Pediatric Pharmacy Practice, Medical University of South Carolina, Charleston, USA.
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced*
D000927:Anticonvulsants; D002220:Carbamazepine