title: Quantitative evidence for increase in galanin-immunoreactive terminals in the hippocampal formation following entorhinal cortex lesions in the adult rat.
abstract: The projection from the entorhinal cortex to the dentate gyrus and hippocampus is severely affected in Alzheimer's disease and there is a depletion of cholinergic terminals but an upregulation of the neuropeptide galanin, which inhibits the release of acetylcholine. Evidence for changes to galanin-immunoreactive terminals in the hippocampal formation was therefore examined after unilateral entorhinal cortex lesions in the adult rat. An increase in the density of galanin-immunoreactive terminals on the lesioned side was evident in the stratum lacunosum moleculare of the hippocampus and the outer molecular layer of the dentate gyrus at 17 days post-lesion, and it increased gradually until the last time point examined, at 40 days post-lesion. Thus we demonstrate that there is an increase in galanin-immunoreactive terminals in the hippocampal formation following entorhinal cortex lesions.
authors.affiliation: School of Biomedical Sciences, University of Leeds, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Harrison
authors.forename: Z
authors.initials: Z
authors.lastname: Henderson
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D019004:Galanin / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D009411:Nerve Endings / Q000502:physiology*; D009434:Neural Pathways / Q000166:cytology / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D015854:Up-Regulation / Q000235:genetics / Q000502:physiology
chemical_list: D019004:Galanin; D000110:Acetylcholinesterase