Undesirable blood pressure changes under naturalistic treatment with moclobemide, a reversible MAO-A inhibitor--results of the drug utilization observation studies.
Blood pressure decrease, associated with postural hypotension, as well as spontaneous hypertension are considered to be typical side-effects of conventional, irreversible and nonselective MAO (A+B) inhibitors. The new generation of reversible MAO-A inhibitors is, however, expected to have negligible cardiovascular effects and low propensity to induce either blood pressure increases or decreases. But, the true incidence of such changes is largely unknown since observation studies, specifically assessing the frequency of blood pressure changes, in unselected population of patients treated in the practice, are lacking.
Delini-Stula
A
A
CNS Medical Research Counselling, Basle, Switzerland.
Baier
D
D
Kohnen
R
R
Laux
G
G
Philipp
M
M
Scholz
H J
HJ
D000328:Adult; D000368:Aged; D001549:Benzamides / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007022:Hypotension / Q000139:chemically induced*; D007024:Hypotension, Orthostatic / Q000139:chemically induced; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D011446:Prospective Studies
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide