title: Long-term outcome of surgical revascularization in ischemic nephropathy: normalization of average decline in renal function.
abstract: OBJECTIVE
  Renovascular disease may lead to ischemia of the nephrons and to fibrosis, which is generally considered to be irreversible and progressive. We investigated the potential of revascularization to recover and stabilize renal function in patients with ischemic nephropathy.
  
  
  METHODS
  In a retrospective analysis of all our 61 patients with ischemic nephropathy who underwent treatment with surgical revascularization, we determined the long-term course of renal function decline with an estimated glomerular filtration rate (EGFR; Cockcroft and Gault formula). With the assumption of normal renal function at age 25 years, the preoperative slope of EGFR and the postoperative slope of EGFR were determined from the EGFR before surgery, at the short-term follow-up examination (on average, 8 months after surgery), and at the long-term follow-up examination (on average, at 47 months after surgery). These declines in renal function were compared with EGFR values in age-matched and sex-matched samples from a large cross-sectional population study.
  
  
  RESULTS
  The overall surgical mortality rate amounted to 13.1%. Five patients became dialysis dependent-two with preexisting end-stage renal disease and three at later follow-up examination-and two patients, who before surgery were dialysis dependent, could be withdrawn from dialysis treatment. Shortly after the operation, the mean EGFR level had increased from 28.3 to 43.1 mL/min/1.73 m2 ( P <. 01). The rate of decline in renal function had decreased from an estimated -2.57 mL/min/1.73 m2/year before surgery (weighted mean: interquartile range, -2.71 to -1.98) to -0.66 mL/min/1.73 m2/year (weighted mean: interquartile range, -2.00 to -0.18) in the short-term interval to the long-term interval, which was even slightly better than the slope of -0.84 mL/min/1.73 m 2/year in the age-matched and sex-matched control population.
  
  
  CONCLUSIONS
  Surgical revascularization in selected patients with renovascular disease and ischemic nephropathy restores renal function and makes the average long-term rate of decline in renal function equal to that of the general population. This indicates that in most patients a "point-of-no-return" has not yet been passed even though their renal function is already markedly impaired before surgery. Therefore, in well-selected patients with ischemic nephropathy, considerable improvement of renal function can be realized.
authors.affiliation: Department of Surgery, University Hospital Leiden, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: van Rooden
authors.forename: J H
authors.initials: JH
authors.lastname: van Bockel
authors.forename: G G
authors.initials: GG
authors.lastname: De Backer
authors.forename: J
authors.initials: J
authors.lastname: Hermans
authors.forename: P C
authors.initials: PC
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D007511:Ischemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D051437:Renal Insufficiency / Q000097:blood / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D003404:Creatinine