title: Small bowel bacterial overgrowth in subjects living in residential care homes.
abstract: OBJECTIVE
  in elderly people, bacterial overgrowth of the small bowel may be occult. The significance of positive breath tests are uncertain: many fit elderly subjects with positive tests show no evidence of malabsorption. We assessed the prevalence and significance of bacterial overgrowth in the small bowel in a relatively unselected elderly population.
  
  
  METHODS
  residents of seven elderly people's homes had a glucose hydrogen breath test. A medical history and anthropomorphic measurements were recorded. Volunteers with positive breath tests were given doxycycline. After 4 months all volunteers were reassessed.
  
  
  RESULTS
  of 140 residents, 62 were tested. Nine (14.5%) had a positive breath test. There was no difference in anthropomorphic and bowel habit data between those with positive and those with negative breath tests. After 4 months of antibiotic treatment, volunteers with a positive breath test had increased weight and body mass index, while those with a negative test had decreased weight and body mass index.
  
  
  CONCLUSIONS
  the percentage of volunteers with a positive breath test was much lower than in previous studies. This may be due to the relatively unselected nature of the volunteers. Treatment of bacterial overgrowth resulted in a small but significant improvement in anthropometric indices. The lack of association of positive breath tests with baseline anthropomorphic measurements or bowel habit highlights the occult nature of the bacterial overgrowth and questions its clinical importance.
authors.affiliation: Department of Medicine, University of Wales, Heath Park, Cardiff, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: L F
authors.initials: LF
authors.lastname: Potts
authors.forename: R
authors.initials: R
authors.lastname: Malhotra
authors.forename: R
authors.initials: R
authors.lastname: Mountford
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D001944:Breath Tests; D005260:Female; D005947:Glucose / Q000378:metabolism; D006707:Homes for the Aged; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007410:Intestinal Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism / Q000503:physiopathology; D007421:Intestine, Small / Q000378:metabolism / Q000382:microbiology*; D008297:Male; D009735:Nursing Homes
chemical_list: D006859:Hydrogen; D005947:Glucose