Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy.
OBJECTIVE
To investigate the correlation between androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels.


METHODS
39 human prostate cancers and 14 benign prostatic hypertrophy specimens were examined immunohistochemically for androgen receptor expression and by in situ hybridisation and reverse transcription polymerase chain reaction for FGF8 expression.


RESULTS
In 39 tumours there was a statistically significant negative correlation between tumour grade and FGF8 expression and a positive correlation between FGF8 and androgen receptor expression. All 14 benign hypertrophy specimens expressed moderate to high levels of FGF8 and androgen receptor.


CONCLUSIONS
Loss of FGF8 may be a factor involved in the development of prostatic cancer.
Wang
Q
Q
Department of Histopathology, Imperial College School of Medicine, London, UK.
Stamp
G W
GW
Powell
S
S
Abel
P
P
Laniado
M
M
Mahony
C
C
Lalani
E N
EN
Waxman
J
J
D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics; D011944:Receptors, Androgen / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
C496456:FGF8 protein, human; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D011944:Receptors, Androgen; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors