[The cardioprotective effect of perindopril in rats with experimental cardiosclerosis].
Rats with experimental cardiosclerosis detected 21 days after embolization of the coronary arteries were subjected to early chronic perindopril administration (per os, 2 mg/kg once a day on days 2-20 after immobilization. As a result, the number of scars reduced, focal cardiosclerosis, dystrophy and hypertrophy of the cardiomyocytes were less pronounced, and the content of cellular glycogen increased. The cardioprotective effect was attended with a normalizing influence on the renin-angiotensin system parameters which were significantly changed after experimental damage to the myocardium: perindopril restored angiotensin I clearance and the level of angiotensin II production in the lungs.
Kalenikova
E I
EI
Laboratory of Experimental Pharmacology, Cardiological-Production Complex, Russian Federation Ministry of Public Health, Moscow, Russia.
Gorodetskaia
E A
EA
Zakharova
N V
NV
Kuznetsova
T V
TV
Medvedev
O S
OS
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003328:Coronary Thrombosis / Q000097:blood / Q000150:complications / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000473:pathology*; D020913:Perindopril; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012084:Renin-Angiotensin System / Q000187:drug effects; D012598:Sclerosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D002317:Cardiovascular Agents; D007211:Indoles; D020913:Perindopril