Noroudemansin A, a new antifungal antibiotic from Pterula species 82168 and three semisynthetic derivatives.
A new antifungal (E)-beta-methoxyacrylate noroudemansin A (1), was isolated from cultures of Pterula sp. 82168. Its biological activities were investigated and compared with oudemansin A. The structure was elucidated by spectroscopic methods. Three semisynthetic noroudemansin A derivatives were synthesized from the natural product.
Engler-Lohr
M
M
Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
Anke
T
T
Hellwig
V
V
Steglich
W
W
D000179:Acrylates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001487:Basidiomycota; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D005658:Fungi / Q000187:drug effects*; D018922:HL-60 Cells / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010407:Penicillium / Q000187:drug effects; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000179:Acrylates; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; C119933:noroudemansin A