title: Incidence and possible reasons for discordant results between positive FDP and negative D-dimer latex assays in clinical specimens.
abstract: In general, FDP and D-dimer values have a correlation in clinical conditions associated with disseminated intravascular coagulation(DIC) or coagulation activation. However, there are some patients with discordant results who demonstrate elevated FDP and negative D-dimer results by latex agglutination assays. The incidence and possible reasons for the discordance between FDP and D-dimer results were investigated through simultaneous measurements (n = 763) from clinical patients with suspected DIC or coagulation activation. 24.8% (189/763) of samples with elevated FDP were negative for D-dimer assays by the latex agglutination method. Further detailed analysis on randomly-selected discordant samples (n = 41) revealed that the most common reason for the discordance was the lower sensitivity of the semiquantitative latex agglutination method for D-dimer, compared with quantitative enzyme or other latex immunoassay. The other contributing factors to the discordance were accelerated fibrinogenolysis without secondary fibrinolysis, elevated soluble fibrin monomer and rheumatoid factor.
authors.affiliation: Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea. kssong@yumc.yonsei.ac.kr
authors.forename: K S
authors.initials: KS
authors.lastname: Song
authors.forename: Y A
authors.initials: YA
authors.lastname: Kim
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: Q
authors.initials: Q
authors.lastname: Park
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood*; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D007841:Latex Fixation Tests
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D