title: HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.
abstract: HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1-->p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3-D1 and human 2p13.1-->p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX11L1 (Tlx2).
authors.affiliation: Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova-Quarto, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Puliti
authors.forename: R
authors.initials: R
authors.lastname: Cinti
authors.forename: N
authors.initials: N
authors.lastname: Betsos
authors.forename: G
authors.initials: G
authors.lastname: Romeo
authors.forename: I
authors.initials: I
authors.lastname: Ceccherini
mesh_terms: D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005801:Genes, Homeobox; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007422:Intestines / Q000294:innervation / Q000473:pathology; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D010641:Phenotype; D013045:Species Specificity
chemical_list: D017931:DNA Primers