CD5+ persistent polyclonal B-cell lymphocytosis in a male.
Persistent polyclonal B-cell lymphocytosis with binucleate lymphocytes is a rare lymphoproliferative syndrome of uncertain cause that is strongly associated with HLA-DR7 positivity, cigarette smoking, and female sex. As yet, there is no explanation for the strong sex predilection. We report the third case of persistent polyclonal B-cell lymphocytosis in a male. Other notable findings in this case are lack of HLA-DR7 and strong positive CD5 markers in the polyclonal B-cell population. To our knowledge, CD5 expression has not been mentioned or reported in association with this syndrome.
Reeder
C B
CB
Department of Laboratory Medicine and Pathology, Mayo Clinic Scottsdale, Arizona 85259, USA.
Conley
C R
CR
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D018956:CD5 Antigens; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008218:Lymphocytosis; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000473:pathology; D008297:Male
D018956:CD5 Antigens