Correlation and prognostic value of serum soluble ICAM-1, beta-2 microglobulin, and IL-2alphaR levels in non-Hodgkin's lymphoma.
Serum levels of sICAM-1, sIL-2alphaR, and beta-2 microglobulin were measured in 63 patients with non-Hodgkin's lymphoma (NHL). The correlation between these serum markers as well as their relationship with NHL features and disease outcome were analyzed. Although in high-grade NHL sICAM-1 levels correlated with tumor mass, no correlation was found between sICAM-1 levels and tumor burden in low-grade NHL. When compared with sICAM-1 and beta-2 microglobulin, sIL-2alphaR showed the strongest correlation with the tumor burden. However, in multivariate analysis, including serum markers employed as continuous variables, the only parameteres which entered the regression model were beta-2 microglobulin (p=0.012) and sICAM-1 (p=0.019). In a dichotomized model, beta-2 microglobulin, aggressive histology, sICAM-1, age and number of nodal involved sites were found to be prognostically significant. Finally, by combining sICAM-1 and beta-2 microglobulin serum levels, a simple prognostic model useful for NHL was obtained.
Pérez-Encinas
M
M
Division of Hematology, Hospital General de Galicia, University of Santiago de Compostela, Spain.
Quintas
A
A
Bendaña
A
A
Rabuñal
M J
MJ
Bello
J L
JL
D014408:Biomarkers, Tumor; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000503:physiopathology; D015999:Multivariate Analysis; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2; D001613:beta 2-Microglobulin; D018799:Intercellular Adhesion Molecule-1