Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
We report two cases of HIV-infected patients who presented with diffuse interstitial micronodular lesions on chest X-ray after institution of protease inhibitor-containing highly active antiretroviral therapy (HAART). Granulomatous pulmonary disorder mimicking sarcoidosis was diagnosed on histopathological studies revealing noncaseating granuloma and bronchoalveolar lavage analysis showing an intense CD4(+) lymphocyte alveolitis. Causative agents such as infectious organisms and environmental compounds were excluded. The relationship between sarcoid-like reaction and immune reconstitution under HAART is discussed.
Naccache
J M
JM
Services de Pneumologie et de Réanimation Respiratoire, d'Anatomie-Pathologique, et d'Histologie Biologie Tumorale, Hôpital Tenon, Paris, France.
Antoine
M
M
Wislez
M
M
Fleury-Feith
J
J
Oksenhendler
E
E
Mayaud
C
C
Cadranel
J
J
D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000139:chemically induced* / Q000473:pathology*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000473:pathology*
D019380:Anti-HIV Agents