title: Quantitative systolic and diastolic transmyocardial velocity gradients assessed by M-mode colour Doppler tissue imaging as reliable indicators of regional left ventricular function after acute myocardial infarction.
abstract: OBJECTIVE
  The aim of this study was to determine whether myocardial velocity gradients assessed by M-mode colour Doppler tissue imaging could be of clinical relevance and represent reliable indicators of regional left ventricular function after acute myocardial infarction.
  
  
  RESULTS
  Among 64 consecutive patients with a first acute myocardial infarction, in 50 who had a marked asynergy in the parasternal short-axis view at the mid-papillary muscle level, myocardial velocities and velocity gradients were assessed in the anteroseptum and posterior wall by M-mode Doppler tissue imaging. Similar measurements were obtained in 11 matched healthy volunteers who served as a control group. In patients with anterior myocardial infarction, the peak myocardial velocity gradient in the anteroseptum was significantly lower when compared with controls (mean +/- [SD] 0.0 +/- 0.5 vs 1.1 +/- 0.7 s-1 during systole, P < 0.01; and 0.3 +/- 0.6 vs 2.0 +/- 0.5 s-1 during diastole, P < 0.01). Conversely, the peak systolic myocardial velocity gradient in the posterior wall was significantly higher than in controls (2.6 +/- 1.2 vs 1.8 +/- 1.2 s-1, P < 0.05). In patients with inferior myocardial infarction, the peak velocity gradient in the posterior wall was significantly lower when compared with healthy subjects (0.9 +/- 0.6 vs 1.8 +/- 1.2 s-1 during systole and 1.4 +/- 1.4 vs 4.9 +/- 1.2 s-1 during diastole, both P < 0.01). The peak systolic tissue velocity gradient in the anteroseptum was significantly higher than in controls (2.1 +/- 1.0 vs 1.1 +/- 0.7 s-1, P < 0.01).
  
  
  CONCLUSIONS
  The present study indicates that myocardial velocity gradients assessed by M-mode Doppler tissue imaging are of clinical relevance for the characterization of ischaemic myocardial dysfunction after infarction and may provide quantitative assessment of segmental left ventricular function in this clinical setting.
authors.affiliation: Department of Cardiology, Henri Mondor University Hospital, Créteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Garot
authors.forename: G A
authors.initials: GA
authors.lastname: Derumeaux
authors.forename: J L
authors.initials: JL
authors.lastname: Monin
authors.forename: A M
authors.initials: AM
authors.lastname: Duval-Moulin
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: D
authors.initials: D
authors.lastname: Pascal
authors.forename: A
authors.initials: A
authors.lastname: Castaigne
authors.forename: J L
authors.initials: JL
authors.lastname: Dubois-Randé
authors.forename: B
authors.initials: B
authors.lastname: Diebold
authors.forename: P
authors.initials: P
authors.lastname: Guéret
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology