title: [Clinical and instrumental diagnosis of cardiac affection in patients with toxic diphtheria].
abstract: OBJECTIVE
  To specify myocardial affection in adult patients with toxic diphtheria (TD).
  
  
  METHODS
  Along with routine clinical examination 150 patients with toxic diphtheria underwent ECG, echo-CG and biochemical tests. 22, 81, 26, 14 and 7 patients had subtoxic TD, toxic form of the first degree, second degree, third degree and hemorrhagic TD, respectively.
  
  
  RESULTS
  Myocardial impairment in TD develops very early, but is diagnosed in different time depending on the diagnostic technique. Early signs of myocardial involvement are activation of cardiospecific enzymes and echo-CG changes. Poor myocardial prognosis in TD is predetermined by progressive cardiac failure (primarily right ventricular), marked conduction disorders, diminished contractility, hyper- or hypoactivity of cardiospecific enzymes.
  
  
  CONCLUSIONS
  The knowledge of myocardial affection variants in TD enables the clinician not only to predict the disease course but to conduct more adequate therapy resultant in less numerous lethal outcomes of toxic TD.
authors.forename: N D
authors.initials: ND
authors.lastname: Iushchuk
authors.forename: P G
authors.initials: PG
authors.lastname: Filippov
authors.forename: M G
authors.initials: MG
authors.lastname: Filippov
authors.forename: I M
authors.initials: IM
authors.lastname: Roslyĭ
authors.forename: S V
authors.initials: SV
authors.lastname: Maev
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D003935:Diagnostic Techniques, Cardiovascular / Q000295:instrumentation*; D004165:Diphtheria / Q000150:complications*; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D012189:Retrospective Studies
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase