title: [Myocardial distribution of iodine-123-iodophenyl-9-methyl-pentadecanoic acid (9MPA) in patients with acute myocardial infarction: comparison with regional wall motion obtained from technetium-99m-sestamibi gated SPECT].
abstract: 123I-iodophenyl-9-methyl-pentadecanoic acid (9MPA) is a modified long-chain (15 carbons) fatty acid with a methyl branch on its 9 carbon location. Myocardial SPECT images (two sets, 10 min each) were obtained starting 10 min (early phase) and 50 min (delay phase) after the injection of 160 MBq 123I-9MPA at rest in 10 patients with acute myocardial infarction. The segmental myocardial uptake (% uptake) and clearance (% washout) from early to delay image were calculated by the SPECT data. ECG-gated myocardial SPECT with 99mTc-sestamibi was also performed and segmental left ventricular (LV) wall motion was evaluated using QGS (quantitative gated SPECT) program. The % uptake of LV segments with hypokinetic or akinetic wall motion were significantly lower than those with normokinesis (p < 0.01) for both early and delay phases. The % washout of hypokinetic segments were significantly lower than those of normokinetic regions (p < 0.01), while the % washout of akinetic segments were significantly higher than those of severely hypokinetic segments (p < 0.05). Thus, 123I-9MPA myocardial distribution and clearance thought to be associated with left ventricular regional wall motion.
authors.affiliation: Department of Radiology, Nippon Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Kumita
authors.forename: T
authors.initials: T
authors.lastname: Kijima
authors.forename: H
authors.initials: H
authors.lastname: Nakajo
authors.forename: K
authors.initials: K
authors.lastname: Cho
authors.forename: S
authors.initials: S
authors.lastname: Mizumura
authors.forename: T
authors.initials: T
authors.lastname: Kumazaki
authors.forename: J
authors.initials: J
authors.lastname: Sano
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: Y
authors.initials: Y
authors.lastname: Kusama
authors.forename: K
authors.initials: K
authors.lastname: Munakata
authors.forename: H
authors.initials: H
authors.lastname: Kishida
mesh_terms: D005227:Fatty Acids; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid; D017256:Technetium Tc 99m Sestamibi