Intraoperative corticosteroids in acoustic tumor surgery.
BACKGROUND
Corticosteroids are frequently used for the prevention and treatment of neural edema. Although perioperative steroid therapy has been used in patients undergoing acoustic neuroma removal, the efficacy of such therapy has not been previously documented.


METHODS
A retrospective review of 169 patients who underwent acoustic neuroma surgery with (n = 75) or without (n = 94) a single dose of intraoperative corticosteroids was performed. Tumor size ranged from 0.4 cm to 6 cm (mean, 2.1; SD, 1.0) The translabyrinthine approach was used in 85% of the patients, and the middle cranial fossa approach was used in 13%. Data were analyzed for differences in postoperative facial function and complication rates.


RESULTS
After controlling for differences in tumor size, no significant effects of steroid therapy were found for any of the outcome variables.


CONCLUSIONS
This retrospective study showed no apparent benefit from intraoperative steroid use in acoustic neuroma surgery. A prospective, randomized, placebo-controlled trial should be performed to confirm these findings.
Buchman
C A
CA
Department of Otolaryngology, University of Miami School of Medicine, Florida, USA.
Fucci
M J
MJ
Slattery
W H
WH
Brackmann
D E
DE
Berliner
K I
KI
D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003390:Cranial Nerve Neoplasms / Q000188:drug therapy*; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005154:Facial Nerve / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009464:Neuroma, Acoustic / Q000188:drug therapy*; D011183:Postoperative Complications / Q000175:diagnosis; D012189:Retrospective Studies
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone