[Polymyositis induced by tiopronine].
BACKGROUND
D-penicillamine-induced muscle disorders are well-known, tiopronine-induced disorders are less often reported.


METHODS
A 62-year-old patient, given tiopronine for rheumatoid arthritis, developed severe polymyositis with characteristic clinical and pathology features. The course was favorable after tiopronine withdrawal and substitution with methotrexate.


CONCLUSIONS
Clinicians should be aware of the side-effects of tiopronine, particularly muscle disorders, and implement careful surveillance to achieve early diagnosis and appropriate therapy.
Cacoub
P
P
Service de Médecine interne, CHU Pitié-Salpêtrière, Paris. patrice.cacoub@psl.ap-hop-paris.fr
Sbaï
A
A
Azizi
P
P
Gatfosse
M
M
Godeau
P
P
Piette
J C
JC
D000596:Amino Acids / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D017285:Polymyositis / Q000139:chemically induced* / Q000188:drug therapy; D008625:Tiopronin / Q000009:adverse effects / Q000627:therapeutic use*
D000596:Amino Acids; D008625:Tiopronin; D008727:Methotrexate