Regulation of leukocyte trafficking by lipoxins.
Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.
Diamond
P
P
Department of Medicine and Therapeutics, Centre for Vascular Inflammation and Vascular Research, University College Dublin, Mater Misericordiae Hospital, Ireland.
McGinty
A
A
Sugrue
D
D
Brady
H R
HR
Godson
C
C
D001095:Arachidonic Acids / Q000096:biosynthesis / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D009504:Neutrophils / Q000166:cytology*
D001095:Arachidonic Acids