Syntheses of (+/-)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation.
The first total syntheses of (+/-)-shinflavanone and its structural analogues were achieved. (+/-)-Shinflavanone, appears to be a strong inhibitor of bone resorption pits formation by osteoclast-like cell induced by 1alpha, 25-dihydroxy vitamine D3 (IC50 = 0.70 microg/mL).
Suh
H
H
Department of Chemistry, Pusan National University, Korea.
Lee
S
S
Kim
N
N
Han
J
J
Kim
J
J
D001862:Bone Resorption / Q000517:prevention & control*; D002117:Calcitriol / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010010:Osteoclasts / Q000187:drug effects
D044950:Flavanones; D005419:Flavonoids; C120093:shinflavanone; D002117:Calcitriol