title: Role of lysosomes on human ulcerogenic gastropathies. Effect of zinc ion on the lysosomal stability.
abstract: Numerous conditions are involved in the equilibrium between protective and aggressive factors for gastric mucosa injuring. Among them the lysosomal membrane stability plays a very important role in the inflammatory process. Zinc ion is a well-known lysosomal membrane stabilizer. When given orally to animals or even to humans it protects gastric mucosa against erosive lesions induced by a variety of experimental conditions. Compared with the control group (8.45 +/- 1.49 mU/mg) the lysosomes isolated from samples of gastric mucosa obtained from patients suffering of erosive gastropathies, showed a great liability on their membranes (18.37 +/- 4.52 mU/mg). When these patients were treated orally with zinc sulfate (100 mg of zinc element, twice a day, for two weeks) the lysosomes isolated from their gastric mucosa showed a strong reduction on enzymatic activity (5.49 +/- 1.02 mU/mg), probably due to increasing on the membrane stability. Based on these experimental findings we propose the use of zinc ion as an important adjuvant in treatment of erosive gastropathies.
authors.affiliation: Biochemistry Department, Instituto de Ciências da Saúde, Federal University of Bahia, Salvador, Brazil.
authors.forename: L E
authors.initials: LE
authors.lastname: Rodrigues
authors.forename: I B
authors.initials: IB
authors.lastname: Paes
authors.forename: H
authors.initials: H
authors.lastname: Jacobina
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D015032:Zinc / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000135:Acid Phosphatase; D015032:Zinc