title: The thalamus and the schizophrenia phenotype: failure to replicate reduced volume.
abstract: BACKGROUND
  Thalamic abnormalities resulting in impaired attention and information processing may form a foundation for cognitive and perceptual disturbances in schizophrenia. Measurements of the thalamus in patients with schizophrenia have shown reductions relative to normal comparison subjects.
  
  
  METHODS
  In the current project, magnetic resonance images of the brain were obtained in 10 male and 11 female subjects with paranoid-type schizophrenia, and 15 male and 12 female normal comparison subjects. Total brain and bilateral thalamic volumes were calculated.
  
  
  RESULTS
  There were no significant diagnosis, hemisphere, or gender differences in thalamic volumes.
  
  
  CONCLUSIONS
  Structural thalamic abnormalities are not likely to universally and parsimoniously explain the schizophrenia phenotype. Abnormal thalamic size in patients with schizophrenia should be understood as reflecting one of several possible structural abnormalities contributing to production of the schizophrenia phenotype, but must be regarded with caution unless paired with functional studies.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: D
authors.initials: D
authors.lastname: Arciniegas
authors.forename: D C
authors.initials: DC
authors.lastname: Rojas
authors.forename: P
authors.initials: P
authors.lastname: Teale
authors.forename: J
authors.initials: J
authors.lastname: Sheeder
authors.forename: E
authors.initials: E
authors.lastname: Sandberg
authors.forename: M
authors.initials: M
authors.lastname: Reite
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000706:statistics & numerical data; D008297:Male; D010641:Phenotype; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D013788:Thalamus / Q000033:anatomy & histology*