title: [Cortexin effectiveness in circulatory encephalopathy].
abstract: A clinical trial of cortexin, a new peptide bioregulator of cerebral functions, in combined therapy of dyscirculatory encephalopathy (DE) stage I-II was made in 76 patients. They were divided into two groups: a control group of 31 patients on standard therapy and the study group of 45 patients on standard therapy with adjuvant cortexin delivered via nasal electrophoresis (NE). The effect was estimated by clinical symptoms, psychophysiological tests, computed EEG, quantitative parameters of rehabilitation. Cortexin NE produced a positive effect on psychoemotional state, neurological status, intellectual-mnestic and CNS functions. Adjuvant cortexin aroused efficiency of rehabilitation in DE stage I and II by 22.7%. The response of intellectual-mnestic and CNS functions was the highest. Cortexin improves attention, perception, memory, thinking, cortical neurodynamic processes. It is well tolerated and has no side effects. Cortexin is recommended as a drug of choice in combined treatment of patients with DE stage I-II.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: V G
authors.initials: VG
authors.lastname: Morozov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Rybnikov
authors.forename: N G
authors.initials: NG
authors.lastname: Zakutskiĭ
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000188:drug therapy*; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D011581:Psychological Tests; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C056590:cortexin