title: Lack of influence of menstrual cycle and premenstrual syndrome diagnosis on pregnanolone pharmacokinetics.
abstract: OBJECTIVE
  Pregnanolone is a 3alpha-hydroxylated-5beta-reduced metabolite of the female sex steroid hormone progesterone. The compound is currently being evaluated for anaesthetic purposes. Previous studies have indicated a differential physiological response across the menstrual cycle and a different response in patients with premenstrual syndrome (PMS). This study was undertaken to determine whether hormonal changes during the menstrual cycle influence pregnanolone pharmacokinetics and to compare PMS diagnosis-related differences in pregnanolone pharmacokinetics.
  
  
  METHODS
  Seven patients with premenstrual syndrome and seven female controls were given three increasing doses of pregnanolone in the follicular and luteal phase of the menstrual cycle.
  
  
  RESULTS
  Mean pregnanolone elimination half-life varied between 28.4 min and 31.8 min and clearance between 59.6 ml x min(-1) x kg(-1) and 64.0 ml x min(-1) x kg(-1), depending on diagnostic group and cycle phase. No significant differences in pregnanolone pharmacokinetic properties were found between PMS patients and controls in either phase of the menstrual cycle. Furthermore, no differences in pharmacokinetic variables were detected between cycle phases.
  
  
  CONCLUSIONS
  Pregnanolone pharmacokinetics do not differ between follicular and luteal phase of the menstrual cycle, nor between PMS patients and control subjects.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital of Umeå, Sweden. inger.sundstrom@obstgyn.umu.se
authors.forename: I
authors.initials: I
authors.lastname: Sundström
authors.forename: O
authors.initials: O
authors.lastname: Spigset
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: P
authors.initials: P
authors.lastname: Appelblad
authors.forename: T
authors.initials: T
authors.lastname: Bäckström
mesh_terms: D000328:Adult; D019540:Area Under Curve; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase / Q000378:metabolism; D008597:Menstrual Cycle / Q000378:metabolism*; D011280:Pregnanolone / Q000097:blood / Q000493:pharmacokinetics*; D011293:Premenstrual Syndrome / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D011280:Pregnanolone