[Diazepam-induced chromosome aberrations in human lymphocytes in vitro].
This paper reports results of the research of genotoxic effects of anxiolitic benzodiazepine diazepam in the culture of lymphocytes of human periphery blood. It has been found out that diazepam reduces lymphocytes mitotic activity, causes numeric chromosomal aberrations (mostly hypodiploidy), and shows cytotoxic reactions. Frequency and expressiveness of perceived effects are in correlation with the intensity of concentrations tested.
Ibrulj
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Katedra za medicinsku biologiju sa humanom genetikom, Institut za humanu genetiku, Medicinski fakultet Sarajevo.
Nefić
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H
D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003975:Diazepam / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009152:Mutagenicity Tests
D014151:Anti-Anxiety Agents; D003975:Diazepam