A new antibiotic nortriterpene quinone methide from Maytenus catingarum.
15alpha-Hydroxy-21-keto-pristimerine (1), a new nortriterpene quinone methide was isolated from the root bark of Maytenus catingarum along with other well-known related compounds, including pristimerine (2), tingenone, and 20alpha-hydroxy-tingenone. The structure of 1 was determined by means of 1H and 13C NMR spectroscopy, including homonuclear and heteronuclear correlations. Compound 1 showed antibiotic activity against Gram-positive bacteria.
Alvarenga
N L
NL
Departamento de Fitoquímica, Dirección de Investigación, Facultad de Ciencias Químicas de la Universidad Nacional de Asunción, P.O. Box 1.055 Asunción, Paraguay. na-fcq@sce.cnc.una.py
Velázquez
C A
CA
Gómez
R
R
Canela
N J
NJ
Bazzocchi
I L
IL
Ferro
E A
EA
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009654:Norsteroids / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C120211:15-hydroxy-21-ketopristimerine; D000900:Anti-Bacterial Agents; D009654:Norsteroids