title: The use of a modified Dakin's solution (sodium hypochlorite) in the treatment of Vibrio vulnificus infection.
abstract: We report the first clinical use of a modified Dakin's solution (0.025% sodium hypochlorite [NaOCl]) to halt the progress of severe cutaneous Vibrio vulnificus infection in a critically ill patient. The regimen used arose from an initial in vitro study designed to examine the sensitivity of Vibrio species to topical antimicrobial agents. Twenty-eight wound isolates were tested against the following eight topical preparations: silver sulfadiazine (Silvadene), nitrofurazone, mupirocin ointment (Bactroban), polymyxin B/bacitracin, mafenide acetate (Sulfamylon), nystatin/Silvadene, nystatin/polymyxin B/bacitracin, and 0.025% NaOCl solution. The results showed that V vulnificus, along with the other 18 Vibrio species tested, was most sensitive to the modified NaOCl solution.
authors.affiliation: Institute for Plastic and Reconstructive Surgery, Southern Illinois University of School of Medicine, Springfield, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Milner
authors.forename: J P
authors.initials: JP
authors.lastname: Heggers
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002481:Cellulitis / Q000188:drug therapy; D016638:Critical Illness; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D012973:Sodium Hypochlorite / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014733:Vibrio / Q000187:drug effects* / Q000302:isolation & purification; D014735:Vibrio Infections / Q000188:drug therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D012973:Sodium Hypochlorite