Correlation of lining thickness and expression of alpha 2 and alpha 3 integrins within the epithelial lining of odontogenic cysts.
Using monoclonal antibodies, we performed immunohistochemical investigations of the expression of alpha 2, alpha 3 and beta 4 integrin subunits within the squamous epithelial linings of odontogenic cysts. Tissue samples consisted of both follicular cysts and odontogenic keratocysts from 15 patients. It was found that beta 4 integrin was expressed on the basement membrane regardless of the histological type of the cyst. The degree of immunostaining for alpha 2 and alpha 3 integrin expression corresponded to the thickness of the epithelial cyst wall. We found that the thickness of the epithelial lining of odontogenic cysts had a direct correlation with the expression of integrin molecules.
Nishimura
A
A
Graduate School of Dentistry (Oral and Maxillofacial Surgery), Osaka Dental University, Japan.
Ueno
S
S
Niwa
S
S
Osugi
Y
Y
Shinoda
Y
Y
Mushimoto
K
K
Shirasu
R
R
D015703:Antigens, CD / Q000096:biosynthesis*; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D039421:Integrin alpha2; D039422:Integrin alpha3; D039663:Integrin beta4; D016023:Integrins / Q000096:biosynthesis*; D009807:Odontogenic Cysts / Q000378:metabolism* / Q000473:pathology*
D015703:Antigens, CD; D039421:Integrin alpha2; D039422:Integrin alpha3; D039663:Integrin beta4; D016023:Integrins