title: Regulation of leukocyte trafficking by lipoxins.
abstract: Lipoxins are lipoxygenase interaction products formed by transcellular metabolism during host defence and inflammation. In model systems, lipoxins modulate polymorphonuclear leukocytes (PMN) chemotaxis, adhesion molecule expression, inhibit PMN-endothelial cell adhesion, and attenuate cytokine release from epithelial cells. These observations raise the possibility that lipoxins are 'stop signals' for PMN-mediated tissue injury and promote the resolution of acute inflammation.
authors.affiliation: Department of Medicine and Therapeutics, Centre for Vascular Inflammation and Vascular Research, University College Dublin, Mater Misericordiae Hospital, Ireland.
authors.forename: P
authors.initials: P
authors.lastname: Diamond
authors.forename: A
authors.initials: A
authors.lastname: McGinty
authors.forename: D
authors.initials: D
authors.lastname: Sugrue
authors.forename: H R
authors.initials: HR
authors.lastname: Brady
authors.forename: C
authors.initials: C
authors.lastname: Godson
mesh_terms: D001095:Arachidonic Acids / Q000096:biosynthesis / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D009504:Neutrophils / Q000166:cytology*
chemical_list: D001095:Arachidonic Acids