title: Expression of the hyaluronan receptor, CD44S, in epithelial ovarian cancer is an independent predictor of survival.
abstract: Most ovarian carcinomas present at advanced stage, principally as the result of dissemination to peritoneal sites. Standard CD44 (CD44S) is the principal receptor for hyaluronic acid, and in vitro and animal studies have suggested that the attachment of ovarian carcinoma cells to the peritoneal mesothelium involves the interaction between CD44S on ovarian carcinoma cells and hyaluronic acid on mesothelial surfaces. We, therefore, analyzed a series of ovarian carcinomas for the expression of CD44S by immunohistochemistry to see whether expression of this receptor by tumor cells correlated with clinicopathological factors and measures of patient outcome. Fifty-six fixed, paraffin-embedded primary epithelial ovarian tumors were immunostained with antibody to CD44S. Membrane staining was considered positive, and results were correlated with stage, grade, age, histology, and survival. Twenty-two (39%) tumors were positive for CD44S. There was no correlation between CD44 expression and histological type, grade, age, or stage. However, CD44 expression was significantly associated with survival in both univariate (P = 0.003) and multivariate (P = 0.006) analyses. These results support a role for CD44S expression in the spread of ovarian epithelial cancer and suggest that expression of this molecule is a significant independent predictor of survival in women with this disease.
authors.affiliation: Division of Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kayastha
authors.forename: A N
authors.initials: AN
authors.lastname: Freedman
authors.forename: M S
authors.initials: MS
authors.lastname: Piver
authors.forename: J
authors.initials: J
authors.lastname: Mukkamalla
authors.forename: M
authors.initials: M
authors.lastname: Romero-Guittierez
authors.forename: B A
authors.initials: BA
authors.lastname: Werness
mesh_terms: D000367:Age Factors; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D002448:Cell Adhesion; D002454:Cell Differentiation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D006820:Hyaluronic Acid / Q000502:physiology; D015993:Life Tables; D009363:Neoplasm Proteins / Q000032:analysis*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D018960:Hyaluronan Receptors; D009363:Neoplasm Proteins; D006820:Hyaluronic Acid