Electron microscopic and immunohistochemical verification of diagnosis in two archival cases recognized as encephalitis necroticans acuta (ENA) on routine examinations.
Two archival cases diagnosed 20 years ago on routine neuropathological methods as Encephalitis Necroticans Acuta (ENA) were investigated in EM and by immunohistochemical methods. The previous diagnosis was confirmed only in one case because Herpes simplex virus was found. In the second case the intracellular inclusions visible in ME corresponded to Measles Virus thus previous diagnosis was changed to SSPE.
Schmidt-Sidor
B
B
Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa.
Lewandowska
E
E
Wierzba-Bobrowicz
T
T
Gwiazda
E
E
Eibl
M
M
D000293:Adolescent; D002540:Cerebral Cortex / Q000473:pathology* / Q000648:ultrastructure* / Q000821:virology; D003955:Diagnostic Tests, Routine; D017809:Fatal Outcome; D005260:Female; D006561:Herpes Simplex / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000473:pathology* / Q000821:virology; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000648:ultrastructure; D010808:Physical Examination; D018139:Simplexvirus / Q000302:isolation & purification