title: [Study of transforming growth factor-alpha expression in duodenal ulcer].
abstract: Various growth factors were also reported to promote healing of peptic ulcer. We have used a monoclonal antibody in conjunction with a standard immunohistochemical technique to characterize the expression of transforming growth factor-alpha (TGF-alpha) in duodenal ulcer. TGF-alpha immunoreactivity is found in Brunner's gland, also in immature gland and in duodenal epitheliums, but not in gastric metaplasia of the duodenum. TGF-alpha expression of healing and scar stage was higher than that of active stage. The presence or absence of Helicobacter pylori infection did not affect the expression of TGF-alpha in duodenal ulcer.
authors.affiliation: Department of 4th Internal Medicine, Tokyo Medical University.
authors.forename: S
authors.initials: S
authors.lastname: Niki
authors.forename: H
authors.initials: H
authors.lastname: Matsubayashi
authors.forename: T
authors.initials: T
authors.lastname: Mizoue
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuguchi
authors.forename: J
authors.initials: J
authors.lastname: Sanada
authors.forename: K
authors.initials: K
authors.lastname: Takei
authors.forename: K
authors.initials: K
authors.lastname: Miwa
authors.forename: T
authors.initials: T
authors.lastname: Horibe
authors.forename: T
authors.initials: T
authors.lastname: Niido
authors.forename: T
authors.initials: T
authors.lastname: Seki
authors.forename: M
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Saitou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D016211:Transforming Growth Factor alpha / Q000032:analysis*
chemical_list: D016211:Transforming Growth Factor alpha