title: Applying the Sheffield tables to data from general practice.
abstract: Lowering cholesterol with drugs of the statin class reduces the risk of a coronary event. Recent guidelines recommend use of the 'Sheffield tables' to detect individuals who might be offered drug treatment in whom the annual absolute risk of a first coronary event is > or = 3%. Using these tables in a general practice cohort aged 35-68 years, we found that 3% of men and 0.05% of women were above the treatment threshold. Smokers aged over 50 accounted for 85% of people recommended for statin therapy. Almost all smokers would fall below the treatment threshold if they quit smoking.
authors.affiliation: General Practice Research Group, University of Oxford.
authors.forename: J
authors.initials: J
authors.lastname: Muir
authors.forename: A
authors.initials: A
authors.lastname: Fuller
authors.forename: T
authors.initials: T
authors.lastname: Lancaster
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control*; D018579:Patient Selection; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation
chemical_list: D000960:Hypolipidemic Agents