Colon-specific delivery of budesonide with azopolymer-coated pellets: therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
The objective of this study was to achieve colon-specific delivery of budesonide using azopolymer-coated pellets and to accelerate healing of 2,4,6-trinitrobenzenesulphonic acid sodium salt (TNBS)-induced colitis in rats. After oral administration of azopolymer-coated pellets containing budesonide, a significant increase was observed in the therapeutic effects of the drug accompanied by a decrease in its systemic adverse effects when compared with oral administration in saline or rectal administration by enema. In addition, with the use of the colon-specific oral dosage form the dose of budesonide could be reduced. These results suggested that azopolymer-coated pellets may be a useful dosage form for the colon-specific delivery of budesonide as an anti-inflammatory steroid drug to bring about the healing of TNBS-induced colitis in rats.
Tozaki
H
H
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.
Fujita
T
T
Komoike
J
J
Kim
S I
SI
Terashima
H
H
Muranishi
S
S
Okabe
S
S
Yamamoto
A
A
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019819:Budesonide / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D003106:Colon / Q000502:physiology*; D004343:Drug Implants; D004733:Enema; D008297:Male; D011108:Polymers / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014302:Trinitrobenzenesulfonic Acid
D000893:Anti-Inflammatory Agents; D004343:Drug Implants; D011108:Polymers; D019819:Budesonide; D014302:Trinitrobenzenesulfonic Acid