[Usefulness of a pharmacokinetic approach for clinical antineoplastic chemotherapy evaluation].
Pharmacokinetics, which is the study of the drug becoming in the body, is an important approach of new drug evaluation. Anticancer drugs have mostly a very narrow therapeutic index which leads to a delicate clinical use. Pharmacokinetics permits the prediction of the occurrence of iatrogenic toxicities taking into account the interpatient variability of the pharmacokinetic parameters.
Lokiec
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Service de pharmacologie clinique, Centre René-Huguenin, 35, rue Dailly, 92210 Saint-Cloud.
D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000506:poisoning; D019540:Area Under Curve; D002166:Camptothecin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D000077146:Irinotecan; D008657:Metabolic Clearance Rate
D000970:Antineoplastic Agents; D000077146:Irinotecan; D002166:Camptothecin