CSF 5-HIAA correlates with neuroticism in depressed patients.
BACKGROUND
To examine for relationships between neurotransmitters and personality.


METHODS
27 depressed patients had cerebrospinal fluid (CSF) monoamine metabolites measured and completed the Eysenck Personality Questionnaire (EPQ).


RESULTS
CSF concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) correlated significantly with EPQ neuroticism scores.


CONCLUSIONS
Central serotonin may play a role in neuroticism, a personality dimension predisposing to depression.


CONCLUSIONS
The positive correlation may partly reflect collinear relationships between both variables and anxiety/depression.
Roy
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Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07019, USA.
D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D009497:Neurotic Disorders / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000175:diagnosis; D010555:Personality Inventory; D012720:Severity of Illness Index
D006897:Hydroxyindoleacetic Acid