Biological sensors: More than one way to sense oxygen.
Recently determined structures of the oxygen-sensing heme domain of the bacterial protein FixL have revealed a new binding environment and signal transduction mechanism for heme; they have also provided new insights into the diverse 'PAS' domain superfamily.
Pellequer
J L
JL
Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Brudler
R
R
Getzoff
E D
ED
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D006420:Hemeproteins / Q000737:chemistry / Q000378:metabolism*; D000071677:Histidine Kinase; D010100:Oxygen / Q000378:metabolism*; D012231:Rhizobium / Q000378:metabolism*; D015398:Signal Transduction
D001426:Bacterial Proteins; D006420:Hemeproteins; C067929:FixL protein, Bacteria; D000071677:Histidine Kinase; D010100:Oxygen