title: Treatment of major depression in the context of panic disorder.
abstract: BACKGROUND
  Individuals with major depression frequently have panic attacks, and often panic disorder, but rarely have researchers studied the impact of comorbidity of panic on the outcome of psychological treatment of depression.
  
  
  METHODS
  In this study, patients with comorbid panic and depression were first treated with cognitive-behavioral therapy (CBT) for panic. Depression symptoms in this treated group were compared to a group of patients with major depression who were on a minimal therapist contact waitlist. In the second phase of the study, patients in both groups (comorbid and depression-only) were treated with CBT for depression.
  
  
  RESULTS
  CBT for panic had little effect on co-existing depression, suggesting a specificity of action for CBT directed at different disorders. In addition, the presence of current or recently remitted panic attacks or agoraphobic avoidance did not interfere with the outcome of CBT for depression.
  
  
  CONCLUSIONS
  These findings stand in contrast to previous studies showing greater linkage between depression and panic in treatment outcome.
  
  
  CONCLUSIONS
  While there are implications for treatment planning, these conclusions may be limited by the exclusion criteria and the highly structured treatment approach of separating treatment for panic from treatment for depression.
authors.affiliation: Department of Psychology, Yale University, New Haven, CT 06520-8205, USA.
authors.forename: S
authors.initials: S
authors.lastname: Woody
authors.forename: P D
authors.initials: PD
authors.lastname: McLean
authors.forename: S
authors.initials: S
authors.lastname: Taylor
authors.forename: W J
authors.initials: WJ
authors.lastname: Koch
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index