CIIV, MIIC and other compartments for MHC class II loading.
Virtually every endocytic compartment has been claimed to be an MIIC, a site where class II molecules accumulate. Here, it is argued that the definition of MIIC is not accurate and often pointless. MIIC can better be used as a working title for a collection of late endocytic compartments that contain the goodies necessary for efficient peptide loading of class II molecules.
Neefjes
J
J
Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam. jneefjes@nki.nl
D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans
D000949:Histocompatibility Antigens Class II