[Levels of eosinophil cationic protein in serum of infants with wheezy bronchitis].
Wheezy bronchitis is one of the most important problems in pediatric pneumonology. Characteristic of bronchial inflammatory response during acute episode of wheezy bronchitis is not well known. The aim of our study was to examine eosinophil activation marker--eosinophil cationic protein(s-ECP) in infants with wheezy bronchitis. The study group consisted of 69 infants. Mean s-ECP level was 12.51 ug/l. Increased concentration was found in 13 children (18.8%). s-ECP level depended on age (the lowest value in the first three month of life), severity of symptoms and atopic status (higher value in case of severe course of disease and in group with higher IgE level)). There was no difference in s-ECP value between group of children presenting recurrent symptoms and children without respiratory problems in follow-up observation. However in group with frequent episodes of wheezing results of ECP level on first examination were higher than in group with only one or two episodes. Our observation suggests that in infants suffering from wheezy bronchitis eosinophils are activated and s-ECP correlate with severity of symptoms and atopic predisposition.
Breborowicz
A
A
Kliniki Pneumonologiii Dzieciecej Instytutu Pediatrii, Akademii Medycznej w Poznaniu.
Swiatły
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A
Alkiewicz
J
J
D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis*; D001991:Bronchitis / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D012135:Respiratory Sounds / Q000209:etiology; D012260:Ribonucleases
D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D007073:Immunoglobulin E; D012260:Ribonucleases