[The effect of an artificial magnetic field on Salmonella infection in mice].
Experimental Salmonella infection in mice, developing simultaneously with the prolonged action of an artificial constant magnetic field with induction equal to 3 x 10(-4) T, was found to induce a pronounced decrease in nonspecific resistance in the animals. The study of Salmonella population structure revealed that the cells selected the animals subjected to the action of the artificial magnetic field had mostly a lesser number of signs of antibiotic resistance. By the end of the experiment Salmonella cultures isolated from the mice subjected to the action of the artificial magnetic field were characterized by greater virulence and resistance to the bactericidal action of blood serum. The use of sodium nucleinate under the conditions of the action of the artificial magnetic field enhanced the level of anti-infectious protection in the animals, which changed the direction of cell selection in Salmonella population towards cells with a greater number of markers of antibiotic resistance.
Kalutskiĭ
P V
PV
Medical University, Kursk, Russia.
Bel'skiĭ
V V
VV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D007113:Immunity, Innate; D008280:Magnetics / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D009696:Nucleic Acids / Q000627:therapeutic use; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D012486:Salmonella typhimurium / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; C013683:sodium nucleinate