title: Inverse toroidal vesicles: precursors of tubules in sorbitan monostearate organogels.
abstract: Sorbitan monostearate organogels are opaque, thermoreversible semi-solids whose microstructure consists of surfactant tubules dispersed in the organic continuous phase. Inverse toroidal vesicles are the precursors of the surfactant tubules. The gelation process was observed as an isotropic sol phase of sorbitan monostearate in isopropyl myristate was cooled using hot-stage light microscopy. At the gelation temperature, inverse toroidal vesicular structures were seen to grow in the organic phase. These toroids are thought to be analogous to other well-known vesicles, liposomes and niosomes, except for their toroidal (rather than spherical) shape and their inverse nature. They are rather short-lived structures: on further cooling of the sol phase, tubules form in the organic medium: it is speculated that the toroids elongate into tubular shapes or split into rod-shaped segments.
authors.affiliation: Centre for Drug Delivery Research, School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
authors.forename: S
authors.initials: S
authors.lastname: Murdan
authors.forename: G
authors.initials: G
authors.lastname: Gregoriadis
authors.forename: A T
authors.initials: AT
authors.lastname: Florence
mesh_terms: D005782:Gels; D006601:Hexoses / Q000008:administration & dosage*; D019904:Polymethyl Methacrylate; D013501:Surface-Active Agents / Q000008:administration & dosage*
chemical_list: D005782:Gels; D006601:Hexoses; D013501:Surface-Active Agents; D019904:Polymethyl Methacrylate; C009298:sorbitan monostearate