[The effect of Cardil (diltiazem) in chronic hypoxia on the cationic balance in the cardiovascular system and on blood viscosity in rats].
Experiments on albino rats showed that injection of cardil (diltiazem) (10.5 mg/kg) daily for 7 days in chronic pressure-chamber hypoxia promoted the correction of hypoxia-induced changes in blood viscosity and cation balance in the erythrocytes, blood plasma, tissues of the abdominal aorta and heart (except for the myocardial Ca2+ content) in decrease of the passive and active Na+ and K+ transport through the erythrocyte membrane, increase of free energy (dFi > 0) of the erythrocyte--plasma--vascular wall system which was reduced in rats kept for 14 days under conditions of hypoxia in a pressure chamber. Chronic hypoxia reduced the anticalcium effect of of cardil (diltiazem) in the myocardial cells and its influence on the increase of the transparietal potential difference in the abdominal aorta.
Pustovalov
A P
AP
Department of Normal Physiology with Course of Medbiophysics, Ryazan State Medical University, Russia.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001273:Atmosphere Exposure Chambers; D001809:Blood Viscosity / Q000187:drug effects*; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D004110:Diltiazem / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004573:Electrolytes / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D000860:Hypoxia / Q000097:blood / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D010949:Plasma / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D004573:Electrolytes; D004110:Diltiazem