Effect of Choto-san, a kampo medicine, on impairment of passive avoidance performance in mice.
In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin1A receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented disturbance in acquiring a passive avoidance response after scopolamine administration, but did not influence the decreased serotonin concentration. These results suggested that Choto-san showed the anti-amnestic effect based on the stimulation of serotonin1A receptors.
Yuzurihara
M
M
Tsumura & Co., Kampo and Pharmacognosy Laboratories, Ibaraki, Japan.
Goto
K
K
Sugimoto
A
A
Ishige
A
A
Komatsu
Y
Y
Shimada
Y
Y
Terasawa
K
K
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010879:Piperazines / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D010879:Piperazines; D012702:Serotonin Antagonists; C120250:choto-san; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D012701:Serotonin