title: Tuberculosis control in the Caucasus: successes and constraints in DOTS implementation.
abstract: METHODS
  The pilot projects for tuberculosis (TB) control, supported by the World Health Organization (WHO) and based on the WHO recommended control strategy, directly-observed treatment, short-course (DOTS) in the Caucasian countries (Armenia, Azerbaijan, Georgia).
  
  
  OBJECTIVE
  To evaluate the results 2 years after the implementation of the pilot projects.
  
  
  METHODS
  Analysis of data on case detection, sputum conversion and treatment outcome reported quarterly to the WHO from the Ministries of Health in each country.
  
  
  RESULTS
  Since the establishment of the project, 1330, 764 and 4866 new cases and relapses, respectively, of TB have been detected in the pilot areas of Armenia, Azerbaijan and Georgia. In Armenia and Azerbaijan, respectively 46% and 57% of all cases were smear positive, whilst in Georgia, the corresponding figure was only 12%. After 3 months' treatment, 93% of new smear-positive patients had become smear-negative. The sputum conversion rate for relapses and other retreatment cases (failure, treatment interrupted) was 85%. In Armenia, 78.1% of new smear-positive patients were treated successfully (cured or completed treatment). The corresponding percentages for Azerbaijan and Georgia were 87.9% and 59.6%. Treatment success rates among retreatment cases was generally low, at respectively 46%, 64%, and 35%, in Armenia, Azerbaijan, and Georgia.
  
  
  CONCLUSIONS
  The results of the implementation of the WHO TB control pilot projects in Armenia, Azerbaijan and Georgia suggest that the DOTS strategy is feasible in emergency situations in general, and in the Caucasus in particular.
authors.affiliation: World Health Organization, Global Tuberculosis Programme, Geneva, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Zalesky
authors.forename: F
authors.initials: F
authors.lastname: Abdullajev
authors.forename: G
authors.initials: G
authors.lastname: Khechinashvili
authors.forename: M
authors.initials: M
authors.lastname: Safarian
authors.forename: T
authors.initials: T
authors.lastname: Madaras
authors.forename: M
authors.initials: M
authors.lastname: Grzemska
authors.forename: E
authors.initials: E
authors.lastname: Englund
authors.forename: S
authors.initials: S
authors.lastname: Dittmann
authors.forename: M
authors.initials: M
authors.lastname: Raviglione
mesh_terms: D018563:Disease Notification; D006801:Humans; D015995:Prevalence; D016730:Program Development; D015397:Program Evaluation; D014154:Transcaucasia / Q000453:epidemiology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D014944:World Health Organization