title: New growth hormone secretagogues: C-terminal modified sulfonamide-analogues of NN703.
abstract: The C-terminal the orally active growth hormone secretagogue NN703 was changed to prepare analogues with inverse sulfonamides and inverse amides. The compounds showed high activity in a in vitro rat pituitary model.
authors.affiliation: Health Care Chemistry, Novo Nordisk A/S, Novo Nordisk Park, Måløv, Denmark. bpes@novo.dk
authors.forename: B
authors.initials: B
authors.lastname: Peschke
authors.forename: B S
authors.initials: BS
authors.lastname: Hansen
mesh_terms: D000818:Animals; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis*; D007700:Kinetics; D051381:Rats; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004151:Dipeptides; D007211:Indoles; D013141:Spiro Compounds; D013449:Sulfonamides; C120631:tabimorelin; C094817:ibutamoren mesylate