Activity of gatifloxacin compared to those of five other quinolones versus aerobic and anaerobic isolates from skin and soft tissue samples of human and animal bite wound infections.
The activity of gatifloxacin against 308 aerobes and 112 anaerobes isolated from bite wound infections was studied. Gatifloxacin was active at </=0.016 microg/ml against all 148 Pasteurella isolates (eight species and three subspecies) tested and all other aerobes tested, including Actinobacillus-Haemophilus spp., Eikenella corrodens, Neisseria weaveri, Weeksella zoohelcum, staphylococci, and streptococci. Fusobacteria were sometimes resistant. Gatifloxacin MICs at which 90% of the isolates were inhibited were 0. 125 microg/ml against Bacteroides tectum and Prevotella spp., 0.25 microg/ml against Porphyromonas spp., and 0.5 microg/ml against peptostreptococci.
Goldstein
E J
EJ
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA. EJCGMD@aolc.om
Citron
D M
DM
Merriam
C V
CV
Tyrrell
K
K
Warren
Y
Y
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001733:Bites and Stings / Q000150:complications*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D008826:Microbial Sensitivity Tests; D012874:Skin Diseases, Infectious / Q000382:microbiology*; D018461:Soft Tissue Infections / Q000382:microbiology*; D014946:Wound Infection / Q000382:microbiology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin