[Local application of G-CSF, GM-CSF and EGF in treatment of wounds].
G-CSF, GM-CSF and EGF play an important role in wound healing as components of the cytokine network which regulates cooperation of cells in the repair processes. The first two cytokines have been registered as hematopoietic drugs under the names Neupogen (Roche) and Leucomax (Sandoz). Both G-CSF and GM-CSF stimulate phagocytosis in maturated leucocytes and enhance proliferation of endothelial cells. G-CSF, GM-CSF and EGF which is known as mitogenic agent were applied as topical drugs for wound care; the application resulted in acceleration of wound healing. Preliminary suggestions as to the topical dosage of the cytokines in the treatment of wounds are put forward.
Grzybowski
J
J
Zakład Mikrobiologii i Epidemiologii, Wojskowego Instytutu Higieny i Epidemiologii w Warszawie.
Ołdak
E
E
Janiak
M K
MK
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D004815:Epidermal Growth Factor / Q000008:administration & dosage* / Q000502:physiology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000502:physiology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage* / Q000502:physiology; D006801:Humans; D011994:Recombinant Proteins; D012867:Skin / Q000293:injuries; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000503:physiopathology
D016207:Cytokines; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D004815:Epidermal Growth Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000069585:Filgrastim