Increased insulin-like growth factor-1 protein in human left ventricular hypertrophy.
Animal models of cardiac hypertrophy demonstrated increased expression of insulin-like-growth factor-1 (IGF-1) in the heart. To study protein expression of insulin-like-growth factor 1 in left ventricular hypertrophy (LVH) in humans 11 hearts of autopsy cases with LVH were compared to 11 controls using immunohistochemical staining with anti-human IGF-1. LVH was defined as thickening of the left ventricular wall which ranged from 1.6 to 2.5 cm with hearts weights from 400 to 900 g. Immunohistochemical staining for IGF-1 was increased in the presence of LVH. In cases of LVH 37.9 +/- 3.5% of the cross-sectional myocardial area stained positively for IGF-1 compared to 6.8 +/- 2.9% in controls (P < 0.001). The findings support the hypothesis that IGF-1 has a role in the pathogenesis of LVH in humans. The increase of IGF-1 protein with LVH suggests reactivation of the cardiac IGF-1 genes in the hypertrophied adult cardiomyocyte.
Pauliks
L B
LB
Division of Pediatric Cardiology, Cornell University-New York Presbyterian Hospital, 436 East 69th Street, New York, New York 10021, USA.
Cole
K E
KE
Mergner
W J
WJ
D000328:Adult; D000818:Animals; D001344:Autopsy; D003327:Coronary Disease / Q000150:complications / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009929:Organ Size
D007334:Insulin-Like Growth Factor I