HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.
HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1-->p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3-D1 and human 2p13.1-->p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX11L1 (Tlx2).
Puliti
A
A
Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genova-Quarto, Italy.
Cinti
R
R
Betsos
N
N
Romeo
G
G
Ceccherini
I
I
D000818:Animals; D001483:Base Sequence; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005801:Genes, Homeobox; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007422:Intestines / Q000294:innervation / Q000473:pathology; D051379:Mice / Q000235:genetics*; D018345:Mice, Knockout; D010641:Phenotype; D013045:Species Specificity
D017931:DNA Primers