title: [The relation between mitochondrial DNA mutation and aminogly- coside antibiotics-induced deafness].
abstract: OBJECTIVE
  To nvestigate the relation between mitochondrial DNA mutation and aminoglycoside antibiotics-induced deafness.
  
  
  METHODS
  Mitochondrial DNA (mtDNA) of peripheral blood from 48 sporadic cases was analysed using PCR-BsmAI digestion and PCR-direct DNA silver sequencing.
  
  
  RESULTS
  Six of 48 sporadic patients had A to G mutation in 12S rRNA gene of mtDNA at nucleotide 1555.
  
  
  CONCLUSIONS
  The results suggest that mtDNA 1555(G) mutation is related to the occurring of aminoglycoside antibiotics-induced deafness which can cause genetic susceptibility to aminoglycoside antibotics ototoxicity.
authors.affiliation: Department of Biology, Nanjing Railway Medical College, Nanjing, 210009 P. R. China. LishanZh@jlonline.com
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: D
authors.initials: D
authors.lastname: Qiu
authors.forename: W
authors.initials: W
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000139:chemically induced*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004272:DNA, Mitochondrial