Skin toxicity of propranolol in guinea pigs.
The skin toxicities of propranolol were studied in guinea pigs. In the primary and cumulative skin irritation studies, the skin reactions and the histopathological changes were observed in all animals treated with propranolol, and those tended to increase with the increase of propranolol dosage. The skin reactions increased with the application times of propranolol up to 7 days in the cumulative skin irritation study. In the skin sensitization, the phototoxicity and the skin photosensitization studies, no skin reactions were observed in any animals used in the studies. These results indicate that propranolol caused skin irritation, but was negative for skin sensitization, phototoxicity and skin photosensitization in guinea pigs.
Kobayashi
I
I
Toxicological Research Center, Nitto Denko Corporation, Osaka, Japan.
Hosaka
K
K
Maruo
H
H
Saeki
Y
Y
Kamiyama
M
M
Konno
C
C
Gemba
M
M
D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D000959:Antihypertensive Agents / Q000633:toxicity*; D006168:Guinea Pigs; D007509:Irritants / Q000633:toxicity*; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011433:Propranolol / Q000633:toxicity*; D012867:Skin / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D007509:Irritants; D011433:Propranolol