[The influence of nitrates on platelet oxygen metabolism: in vitro studies].
Our investigations were carried out on human blood platelets obtained from persons aged 20-23, free from any systemic diseases. Drugs were incubated with blood platelets. Changes of antioxidant enzymes were detected. Glyceryl trinitrate increased the activity of Zn Cu-SOD (4.62%) and GPx (275.91%), concentration of ATP (13.01%) and the blood platelets aggregations (17.88%). Izosorbide dinitrate increased the activity of ZnCu-SOD (19.46%), GPx (150.36%) and Cat (15.62%), increased concentration of ATP (23.73%) and blood platelets aggregation (3.64%). Both preparats decreased concentration of MDA (Sustonit--30.79%, Iso-Mack--35.04%). Gliceryl trinitrate decreased the activity of catalase otherwise izosorbide dinitrate increased the activity of this enzyme.
Buczyński
A
A
Zakładu Medycyny Zapobiegawczej Instytutu OOZW WAM w Lodzi.
Dziedziczak-Buczyńska
M
M
Gnitecki
W
W
Kocur
J
J
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D009566:Nitrates / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects
D009566:Nitrates; D010100:Oxygen