title: Posturographic findings in patients with idiopathic cervical dystonia before and after local injections with botulinum toxin.
abstract: In this posturographic study, whole-body postural control was impaired in more than 75% of patients with idiopathic cervical dystonia (ICD) before local injections with botulinum toxin type A (BTX-A) and the impairment was independent of the direction of the torticollis. Six weeks after therapy with BTX-A, the number of pathological posturographic parameters had decreased by almost 30%, and the improvement reached statistical significance for sway path, sway area and anteroposterior sway during stance on foam with eyes closed. From a pathophysiological point of view, this improvement may be explained - at least in part - by a reduction of abnormal proprioceptive input from the neck. Accordingly, it seems possible that neck proprioceptive input plays a role in whole-body postural control in ICD patients, even though previous studies suggested that the neck input is relatively ignored in these patients.
authors.affiliation: Department of Clinical Neurology, University Clinic of Neurology, Vienna, Austria. Christian.Woeber@univie.ac.at
authors.forename: C
authors.initials: C
authors.lastname: Wöber
authors.forename: P
authors.initials: P
authors.lastname: Schnider
authors.forename: N
authors.initials: N
authors.lastname: Steinhoff
authors.forename: S
authors.initials: S
authors.lastname: Trattnig
authors.forename: K
authors.initials: K
authors.lastname: Zebenholzer
authors.forename: E
authors.initials: E
authors.lastname: Auff
mesh_terms: D000328:Adult; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000002:abnormalities; D004333:Drug Administration Routes; D004421:Dystonia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006257:Head / Q000502:physiology; D006801:Humans; D007267:Injections; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D011187:Posture; D011434:Proprioception / Q000502:physiology; D012720:Severity of Illness Index; D013997:Time Factors; D014103:Torticollis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D018726:Anti-Dyskinesia Agents; D019274:Botulinum Toxins, Type A