Isoniazid induced pellagra despite pyridoxine supplementation.
Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed--sometimes with life-threatening consequences. We report a case of isoniazid-induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. The possible mechanisms of isoniazid induced pellagra are discussed.
Darvay
A
A
Department of Dermatology, Ealing Hospital, Southall, UK.
Basarab
T
T
McGregor
J M
JM
Russell-Jones
R
R
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002990:Clobetasol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use; D010383:Pellagra / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011736:Pyridoxine / Q000008:administration & dosage*; D013473:Sunscreening Agents / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000995:Antitubercular Agents; D013473:Sunscreening Agents; D009536:Niacinamide; D002990:Clobetasol; D011736:Pyridoxine; D007538:Isoniazid