[Interferon gamma as a regulator of immune cell function].
The article reviews the literature with regard to identification of lymphocyte subsets that respond to specific inducers and produce IFN-gamma, the structure of IFN-gamma gene, the IFN signal transduction pathway that initiates biochemical changes at cellular level and influences the function of immunocompetent cells: mononuclear phagocytes, T and B lymphocytes. The interaction of IFN-gamma with other cytokines in regulation of immune response is also discussed.
Szuster-Ciesielska
A
A
Zakład Wirusologii i Immunologii, Instytutu Mikrobiologii i Biotechnologii, Uniwersytetu Marii Curie-Skłodowskiej w Lublinie.
Kandefer-Szerszeń
M
M
D000276:Adjuvants, Immunologic / Q000502:physiology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D010587:Phagocytosis / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007371:Interferon-gamma