Skin necrosis in the presence of paclitaxel and fluorometholone.
Paclitaxel (Taxol) can induce full-thickness skin necrosis at sites distant from those of injection. This side effect may be potentiated in the presence of fluorometholone (FML).
Aboolian
A
A
Department of Surgery and Division of Plastic and Reconstructive Surgery, Cabrini Medical Center/The Mount Sinai School of Medicine, New York, NY 10003, USA.
Tornambe
R
R
Ricci
M
M
LaRaja
R D
RD
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D009336:Necrosis; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel; D005469:Fluorometholone