title: Thalidomide responsiveness in an infant with Behçet's syndrome.
abstract: BACKGROUND
  Behçet's syndrome is a chronic relapsing vasculitis characterized by aphthous stomatitis, genital ulcerations, and uveitis. The disease is a multisystem illness, which may involve the skin, joints, gastrointestinal tract, blood vessels, central nervous system, and other organs.
  
  
  METHODS
  We report a case of an infant with features of Behçet's syndrome who did not respond to conventional immunosuppression with high-dose corticosteroids and cytotoxic agents. Thalidomide, a potent immune response-modifying drug, was used with marked improvement and resolution of symptoms.
  
  
  CONCLUSIONS
  This finding supports a trial of thalidomide treatment in patients with Behçet's syndrome who are unresponsive to other forms of immunosuppressive therapy or develop undesirable side effects.
authors.affiliation: Department of Pediatrics, National University of Singapore, Singapore 119074. paeleebw@nus.edu.sg
authors.forename: L P
authors.initials: LP
authors.lastname: Shek
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: B W
authors.initials: BW
authors.lastname: Lee
authors.forename: T J
authors.initials: TJ
authors.lastname: Lehman
mesh_terms: D001528:Behcet Syndrome / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D013792:Thalidomide / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide