[The characteristics of the neuropsychotropic activity of bromantane in laboratory animals].
Bromantan [N-2-(para-(bromphenyl)-N-2-(aminoadamantan)] possesses psychostimulating activity in experiments on animals. With LD50 8100 mg/kg (mice, intraperitoneal injection) activates simple and complicated forms of behavior, induces EEG effects typical of psychostimulators, is an antagonist of substances with a deprivationg neuropsychotropic effect. Bromantan is characterized by a positive effect on mnemonic processes and on obtaining the results of complex operant activity in rats.
Morozov
I S
IS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Klimova
N V
NV
Karpova
T D
TD
Shestopalov
S S
SS
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004569:Electroencephalography / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane