title: Hemodynamic effects of new intra-aortic balloon counterpulsation timing methods in patients: a multicenter evaluation.
abstract: BACKGROUND
  To test whether later intra-aortic balloon pump (IABP) deflation approaching or simultaneous with left ventricular ejection would improve hemodynamics and myocardial efficiency with the use of new balloon deflation methods, 4 IABP timing techniques were evaluated in 43 patients.
  
  
  RESULTS
  Later balloon deflation produced significantly greater percentage changes in mean aortic pressure (6% vs 1%), systolic pressure time index (-27% vs -20%), diastolic pressure time index (35% vs 19%), and the systolic pressure-time index/diastolic pressure-time index ratio (97% vs 51%), respectively. However, these changes increased peak systolic pressure (-15% vs -11%). Cardiac output and stroke volume indexes were not significantly altered over the 4 settings.
  
  
  CONCLUSIONS
  These data suggest that systemic hemodynamics and myocardial efficiency may be improved by later balloon deflation approaching left ventricular ejection in comparison to conventional IABP timing.
authors.affiliation: Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kern
authors.forename: F V
authors.initials: FV
authors.lastname: Aguirre
authors.forename: E A
authors.initials: EA
authors.lastname: Caracciolo
authors.forename: R G
authors.initials: RG
authors.lastname: Bach
authors.forename: T J
authors.initials: TJ
authors.lastname: Donohue
authors.forename: D
authors.initials: D
authors.lastname: Lasorda
authors.forename: E M
authors.initials: EM
authors.lastname: Ohman
authors.forename: R N
authors.initials: RN
authors.lastname: Schnitzler
authors.forename: D L
authors.initials: DL
authors.lastname: King
authors.forename: W J
authors.initials: WJ
authors.lastname: Ohley
authors.forename: J
authors.initials: J
authors.lastname: Grayzel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004452:Echocardiography / Q000379:methods / Q000706:statistics & numerical data; D015150:Echocardiography, Doppler / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014481:United States