Diversity assessment.
Several themes have been highlighted recently in both conferences and publications: the availability of product-focused and pharmacophore-based methods for the analysis and design of combinatorial libraries; the power of cell-based methods for molecular similarity, diversity and library design applications; methods for 'rational' diverse subset selection (with applicability to library design); the need for specialized optimization programs for the design of combinatorial libraries that maximize the use of common reagents; and the concept of 'drug-likeness' and its importance in the design of combinatorial libraries.
Mason
J S
JS
Bristol-Myers Squibb, PO Box 4000, Princeton, NJ 08543, USA. masonj@bms.com
Hermsmeier
M A
MA
D000465:Algorithms; D002625:Chemistry, Organic / Q000379:methods*; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000737:chemistry*
D009930:Organic Chemicals