Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract.
Neuropharmacological studies were conducted in experimental animals (rats and mice) with the methanolic fraction of Bryophyllum pinnatum leaf extract. The fraction produced alteration of behaviour pattern, caused dose-dependent potentiation of pentobarbitone sleeping time and had significant analgesic activity. Significant reduction of exploratory behaviour and loss of residual curiosity were among the effects observed with the fraction. The observations suggest that the methanolic fraction of Bryophyllum pinnatum possesses a potent CNS depressant action.
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Sen
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Chaudhuri
A K
AK
D000698:Analgesia; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000927:Anticonvulsants; D010936:Plant Extracts; D005680:gamma-Aminobutyric Acid; D010424:Pentobarbital; D000432:Methanol