Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients.
OBJECTIVE
To determine whether interleukin 1 alpha (IL-1alpha) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA).


METHODS
A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals.


METHODS
The IL-1alpha promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1alpha intronic microsatellite repeat.


RESULTS
No association was observed between IL-1alpha polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1alpha polymorphisms and chronic anterior uveitis was found.


CONCLUSIONS
IL-1alpha is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1alpha in Norwegian JCA patients.
Donn
R P
RP
ARC/ERU, Manchester, UK.
Farhan
A J
AJ
Barrett
J H
JH
Thomson
W
W
Worthington
J
J
Ollier
W E
WE
D000328:Adult; D001171:Arthritis, Juvenile / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D006113:United Kingdom
D007375:Interleukin-1