title: Assessment of cognition in advanced AD: the test for severe impairment.
abstract: The Test for Severe Impairment (TSI) was compared with the Mini-Mental State Examination (MMSE) and a modified MMSE (mMMSE) in a multisite, longitudinal study of AD. The TSI correlated highly with the MMSE (r = 0.83) and the mMMSE (r = 0.82), but was not redundant. There was a wide range of scores on the TSI among those scoring in the severely impaired range on the MMSE and mMMSE. The slope of cognitive change over time detected by the TSI was greater than that revealed by the MMSE or the mMMSE. Performance on the TSI was a significant predictor of survival. The TSI is a valid measure that is sensitive to cognitive change over time in severely demented patients with AD.
authors.affiliation: Department of Neurology, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. dj32@columbia.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Jacobs
authors.forename: S M
authors.initials: SM
authors.lastname: Albert
authors.forename: M
authors.initials: M
authors.lastname: Sano
authors.forename: C
authors.initials: C
authors.lastname: del Castillo-Castañeda
authors.forename: M C
authors.initials: MC
authors.lastname: Paik
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: K
authors.initials: K
authors.lastname: Bell
authors.forename: J
authors.initials: J
authors.lastname: Brandt
authors.forename: M S
authors.initials: MS
authors.lastname: Albert
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D003072:Cognition Disorders / Q000523:psychology*; D006801:Humans; D009483:Neuropsychological Tests