Bisphosphonates as cancer drugs.
Bone appears to act like fertilizer for many tumors, including myeloma and metastatic breast cancer. The explanation must lie in interactions between tumor cells and the bone-tissue microenvironment. At this level, too, must lie the explanation of how bisphosphonates address not only cancer osteolysis but also the tumor burden. By inhibiting osteoclasts, the drugs may block a cancer-related vicious cycle.
Mundy
G R
GR
Division of Endocrinology and Metabolism, University of Texas Health Science Center at San Antonio, USA.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004002:Clodronic Acid / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D012968:Etidronic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010014:Osteolysis / Q000188:drug therapy*; D000077268:Pamidronate; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology; D000068296:Risedronic Acid; D016212:Transforming Growth Factor beta / Q000502:physiology
D000970:Antineoplastic Agents; D004164:Diphosphonates; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D016212:Transforming Growth Factor beta; D004002:Clodronic Acid; D000068296:Risedronic Acid; D012968:Etidronic Acid; D000077268:Pamidronate