[Immunocytochemical and molecular proof of disseminated tumor cells in bone marrow, peritoneal lavage, blood and regional lymph nodes. A review of the literature and own results].
Immunocytochemical or molecular detection of disseminated tumor cells in different compartments (bone marrow, abdomen, venous blood, lymph nodes) is becoming more and more important in determining the complete extent of the tumor at the time of primary therapy. However, their prognostic relevance is not clear up to now. Whereas their appearance in bone marrow revealed a poor prognosis in some studies, contradictory results have been obtained from examinations of lymph nodes. Moreover peritoneal lavage and venous blood have seldom been examined with these methods. Because standardization of the immunocytochemical or molecular techniques does not exist, therapeutical conclusions can not be drawn from their detection at this time.
Broll
R
R
Chirurgisches Forschungslabor, Medizinischen Universität zu Lübeck.
Windhövel
U
U
Schiedeck
T
T
Duchrow
M
M
Bruch
H P
HP
D001202:Ascitic Fluid / Q000473:pathology; D001769:Blood / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D010533:Peritoneal Lavage; D016133:Polymerase Chain Reaction; D014680:Veins