title: Surgical model to assess the effects and optimal timing of craniofacial fixation.
abstract: An in utero swine model of craniofacial deformity was developed as a potential alternative to neonatal models currently used for evaluating the optimal timing and long-term effects of rigid fixation techniques on a growing cranium. At 75% gestation, seven fetal piglets were randomly selected to undergo periosteal stripping of frontal and parietal bone segments with and without extensive coronal suture fusion procedures with cyanoacrylate adhesive. Fetal swine were killed postpartum at 4 and 11 weeks after fusion to assess craniofacial deformity. Piglets undergoing coronal fusion had slight deviation of the nose-snout toward the side of fusion and taller cranial vaults. The vertical cranial index of the experimental fusion group was 0.34 in comparison to a vertical index of 0.27 for the controls, suggesting abnormal vertical height expansion. There was no difference in the horizontal cranial index of either control or experimental fusion groups. Neither sows nor piglets were lost to anesthetic complications, uterine sepsis, or preterm labor during the initial laparotomy or subsequent cesarean delivery.
authors.affiliation: Division of Plastic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Sims
authors.forename: P E
authors.initials: PE
authors.lastname: Butler
authors.forename: R
authors.initials: R
authors.lastname: Casanova
authors.forename: M A
authors.initials: MA
authors.lastname: Randolph
authors.forename: D K
authors.initials: DK
authors.lastname: Ahn
authors.forename: M J
authors.initials: MJ
authors.lastname: Yaremchuk
mesh_terms: D000818:Animals; D003398:Craniosynostoses / Q000601:surgery*; D004195:Disease Models, Animal; D005146:Facial Asymmetry / Q000196:embryology / Q000601:surgery; D005260:Female; D005333:Fetus / Q000601:surgery*; D011247:Pregnancy; D012886:Skull / Q000254:growth & development*; D013552:Swine; D014014:Tissue Adhesives
chemical_list: D014014:Tissue Adhesives