title: A genome-wide search for linkage to asthma. German Asthma Genetics Group.
abstract: Asthma is among the most frequent chronic diseases in childhood. Although numerous environmental risk factors have already been identified, the basis for familial occurrence of asthma remains unclear. Previous genome screens for atopy in British/Australian families and for asthma in different American populations showed inconsistent results. We report a sib pair study of a sample of 97 families, including 415 persons and 156 sib pairs. Following an extensive clinical evaluation, all participants were genotyped for 351 polymorphic dinucleotide markers. Linkage analysis for asthma identified four chromosomal regions that could to be linked to asthma: chromosome 2 (at marker D2S2298, P = 0.007), chromosome 6 (around D6S291, lowest P = 0.008), chromosome 9 (proximal to D9S1784, P = 0.007), and chromosome 12 (D12S351, P = 0.010). These linkage regions could be reproduced for all loci by analysis of total or specific immunoglobulin E (minimum P values at these regions were 0. 003, 0.001, 0.010, and 0.015, respectively).
authors.affiliation: GSF-Forschungszentrum fuer Umwelt und Gesundheit, Institut fuer Epidemiologie, Neuherberg, Germany. m@wjst.de
authors.forename: M
authors.initials: M
authors.lastname: Wjst
authors.forename: G
authors.initials: G
authors.lastname: Fischer
authors.forename: T
authors.initials: T
authors.lastname: Immervoll
authors.forename: M
authors.initials: M
authors.lastname: Jung
authors.forename: K
authors.initials: K
authors.lastname: Saar
authors.forename: F
authors.initials: F
authors.lastname: Rueschendorf
authors.forename: A
authors.initials: A
authors.lastname: Reis
authors.forename: M
authors.initials: M
authors.lastname: Ulbrecht
authors.forename: M
authors.initials: M
authors.lastname: Gomolka
authors.forename: E H
authors.initials: EH
authors.lastname: Weiss
authors.forename: L
authors.initials: L
authors.lastname: Jaeger
authors.forename: R
authors.initials: R
authors.lastname: Nickel
authors.forename: K
authors.initials: K
authors.lastname: Richter
authors.forename: N I
authors.initials: NI
authors.lastname: Kjellman
authors.forename: M
authors.initials: M
authors.lastname: Griese
authors.forename: A
authors.initials: A
authors.lastname: von Berg
authors.forename: M
authors.initials: M
authors.lastname: Gappa
authors.forename: F
authors.initials: F
authors.lastname: Riedel
authors.forename: M
authors.initials: M
authors.lastname: Boehle
authors.forename: S
authors.initials: S
authors.lastname: van Koningsbruggen
authors.forename: P
authors.initials: P
authors.lastname: Schoberth
authors.forename: R
authors.initials: R
authors.lastname: Szczepanski
authors.forename: W
authors.initials: W
authors.lastname: Dorsch
authors.forename: M
authors.initials: M
authors.lastname: Silbermann
authors.forename: H E
authors.initials: HE
authors.lastname: Wichmann
mesh_terms: D001249:Asthma / Q000097:blood / Q000235:genetics*; D002648:Child; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D015894:Genome, Human; D005858:Germany; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D010641:Phenotype; D011852:Radioallergosorbent Test
chemical_list: D005819:Genetic Markers; D007073:Immunoglobulin E