title: Nonresponsive generalized bacterial infection associated with systemic lupus erythematosus in a Beauceron.
abstract: A case of concurrent canine systemic lupus erythematosus (SLE) and generalized bacterial infection in a six-year-old female Beauceron is reported. The dog presented with purulent nasal and ocular discharges, skin lesions (including seborrhea, hyperkeratotic areas, and papules as well as ecchymoses around the eyes, on both sides of the pinnae, and on the vulva), generalized lymph node enlargement, a mitral murmur, and lameness. Later, facial swelling, a retrobulbar abscess, and a cough also developed. Occurrence of a generalized bacterial infection was established by culture of group-C, beta-hemolytic Streptococcus from the throat, the mouth, a biopsy site (popliteal lymph node area), the retrobulbar abscess, and the lung. The diagnosis of SLE was based on the clinical signs and particularly on the occurrence of antinuclear antibody (ANA) and antidoublestranded-desoxyribonucleic acid (ds-DNA) antibody. Interestingly, the latter type of antibodies were also detected in two young female puppies whelped by this dog. Salient histological findings included an extreme cell depletion of the lymph nodes and spleen and severe pneumonitis and peribronchiolitis. The results of this case indicate that a definite diagnosis of canine SLE can, at times, be made on the basis of the presence of serum ANA and ds-DNA antibodies.
authors.affiliation: Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Clercx
authors.forename: K
authors.initials: K
authors.lastname: McEntee
authors.forename: S
authors.initials: S
authors.lastname: Gilbert
authors.forename: L
authors.initials: L
authors.lastname: Michiels
authors.forename: F
authors.initials: F
authors.lastname: Snaps
authors.forename: E
authors.initials: E
authors.lastname: Jacquinet
authors.forename: D
authors.initials: D
authors.lastname: Desmecht
authors.forename: M
authors.initials: M
authors.lastname: Henroteaux
authors.forename: W E
authors.initials: WE
authors.lastname: Bernadina
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000032:analysis / Q000276:immunology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000276:immunology* / Q000382:microbiology*; D004285:Dogs; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000382:microbiology / Q000662:veterinary*; D013290:Streptococcal Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary*
chemical_list: D000974:Antibodies, Antinuclear; D004247:DNA