Hypothesis: is renal allograft rejection initiated by the response to injury sustained during the transplant process?
Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.
Lu
C Y
CY
Division of Nephrology, Department of Internal Medicine, Dallas, Texas, USA. christopher.lu@email.swmed.edu
Penfield
J G
JG
Kielar
M L
ML
Vazquez
M A
MA
Jeyarajah
D R
DR
D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D007511:Ischemia / Q000209:etiology / Q000276:immunology; D007519:Isoantigens; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000293:injuries; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D019520:Living Donors; D008213:Lymphocyte Activation; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology
D007519:Isoantigens