title: Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients.
abstract: OBJECTIVE
  To determine whether interleukin 1 alpha (IL-1alpha) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA).
  
  
  METHODS
  A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals.
  
  
  METHODS
  The IL-1alpha promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1alpha intronic microsatellite repeat.
  
  
  RESULTS
  No association was observed between IL-1alpha polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1alpha polymorphisms and chronic anterior uveitis was found.
  
  
  CONCLUSIONS
  IL-1alpha is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1alpha in Norwegian JCA patients.
authors.affiliation: ARC/ERU, Manchester, UK.
authors.forename: R P
authors.initials: RP
authors.lastname: Donn
authors.forename: A J
authors.initials: AJ
authors.lastname: Farhan
authors.forename: J H
authors.initials: JH
authors.lastname: Barrett
authors.forename: W
authors.initials: W
authors.lastname: Thomson
authors.forename: J
authors.initials: J
authors.lastname: Worthington
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000328:Adult; D001171:Arthritis, Juvenile / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007375:Interleukin-1 / Q000235:genetics*; D009154:Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D006113:United Kingdom
chemical_list: D007375:Interleukin-1