title: Serum and urine selenium concentrations as indicators of body status in patients with diabetes mellitus.
abstract: Serum and urine selenium levels were determined in patients with diabetes by hydride generation atomic absorption spectrometry. Mean serum selenium concentrations measured in patients with diabetes mellitus (64.9 +/- 22.8 micrograms/l) were significantly lower than those determined in the control group (74.9 +/- 27.3 micrograms/l) (P < 0.05). Mean serum selenium concentrations were not significantly different between the two groups of diabetic patients considered (P > 0.05). Mean urine selenium concentration in diabetic patients (18.8 +/- 10.7 micrograms/l) were not significantly different from those measured in the control group (20.2 +/- 10.1 micrograms/l) (P < 0.05). No significant differences in serum and urine selenium levels were found if related to sex of patients (P > 0.05). Application of linear regression analysis to serum and urine selenium levels and patients' age showed a non-statistically significant correlation (P > 0.05). Given the marked overlap between the two ranges of the populations, the predictive values of serum selenium in diabetic patients are low.
authors.affiliation: Department of Nutrition and Bromatology, Faculty of Pharmacy, University of Granada, Spain. nalarcon@platon.ugr.es
authors.forename: M
authors.initials: M
authors.lastname: Navarro-Alarcón
authors.forename: H
authors.initials: H
authors.lastname: López-G de la Serrana
authors.forename: V
authors.initials: V
authors.lastname: Pérez-Valero
authors.forename: C
authors.initials: C
authors.lastname: López-Martínez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood* / Q000652:urine*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000652:urine; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000097:blood* / Q000652:urine*
chemical_list: D012643:Selenium