title: Prediction of response to revascularization in patients with renal artery stenosis by Tc-99m-ethylenedicysteine captopril scintigraphy.
abstract: The aim of the present study was to assess the predictive value of captopril scintigraphy with the new renal agent 99mTc-ethylenedicysteine (99mTc-EC) for post-interventional improvement in blood pressure. Twelve patients who had persistently high blood pressure with previous demonstration of various degrees of renal artery lesion on angiography were included into the study. Baseline and captopril scintigraphies were performed on the same day at 4 hour intervals after the injection of 74 and 296 MBq of 99mTc-EC, respectively. All patients had percutaneous transluminal angioplasty (PTA), and improvement in blood pressure was evaluated 3-6 months after the intervention. 99mTc-EC captopril scintigraphy successfully predicted a positive or negative outcome in 11 of 12 patients. In one patient with captopril induced renal function deterioration, scintigraphy failed to predict post-interventional response. Our preliminary findings showed that 99mTc-EC captopril scintigraphy can be used to determine patients who will benefit from revascularization.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University Medical School, Ankara, Turkey. ougur@tr-net.net.tr
authors.forename: O
authors.initials: O
authors.lastname: Uğur
authors.forename: M
authors.initials: M
authors.lastname: Serdengeçti
authors.forename: O
authors.initials: O
authors.lastname: Karacalioğlu
authors.forename: E L
authors.initials: EL
authors.lastname: Ergün
authors.forename: I
authors.initials: I
authors.lastname: Peksoy
authors.forename: S
authors.initials: S
authors.lastname: Cekirge
mesh_terms: D000328:Adult; D000800:Angioplasty, Balloon; D002216:Captopril; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C073806:technetium Tc 99m-ethylenedicysteine; D002216:Captopril; D003545:Cysteine