[Association between Kidd blood group and congenital malformations].
BACKGROUND
Since the discovery of blood groups, an association between these genetic polymorphisms and pathological phenotypes has been searched, looking for factors involved in the pathogenesis of diseases or biological population mechanisms that maintain these polymorphisms. In previous reports, we have described some associations between erythrocytic genetic marker segregation and the presence of congenital malformations.


OBJECTIVE
To explore the association between Kidd blood group and congenital malformations.


METHODS
One hundred twenty two malformed newborns and their mothers and 136 normal newborns, seen at the Clinical Hospital of the University of Chile, were studied.


RESULTS
Kidd blood group segregation distortions were found among male malformed newborns, that were not present in normal newborns. Among mothers of both groups of newborns, a paucity of heterozygous for this system was found.


CONCLUSIONS
The association found between a blood group and congenital malformations, allows to state that malformed children have a different genetic background, when compared to normal children.
Cifuentes
L
L
Programa de Genética Humana, Facultad de Medicina, Universidad de Chile, Santiago. lcifuent@machi.med.uchile.cl
Nazer
J
J
Armanet
L
L
D000013:Congenital Abnormalities / Q000097:blood*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007231:Infant, Newborn; D007667:Kidd Blood-Group System; D008297:Male; D015997:Neonatal Screening; D010641:Phenotype
D005819:Genetic Markers; D007667:Kidd Blood-Group System