title: Factors associated with outcome after cord blood transplantation in children with acute leukemia. Eurocord-Cord Blood Transplant Group.
abstract: We have analyzed factors influencing the outcome of 102 children with acute leukemia given a cord blood transplantation (CBT) and reported to the Eurocord Registry. Seventy patients with acute lymphoblastic and 32 with acute myeloid leukemia were given either a related (n = 42) or an unrelated (n = 60) CBT. Children given CBT during first or second complete remission were considered as belonging to the good-risk group (n = 66), whereas those who received a transplant in a more advanced stage of disease were assigned to the poor-risk group (n = 36). In the related group (RCBT), 12 of 42 patients received transplantation from an HLA-disparate donor, whereas in the unrelated group (UCBT) 54 of 60 received an HLA mismatched CBT. Kaplan-Meier estimates for neutrophil recovery at day 60 were 84% +/- 7% in RCBT and 79 +/- 6% in UCBT (P =.16). In multivariate analysis, the most important factor influencing neutrophil engraftment in UCBT was a nucleated cell dose infused greater than 3.7 x 10(7)/kg (P =.05, relative risk [RR] of 1.85, 95% confidence interval [CI]: 0.98-3.4). The incidence of grade II through IV acute graft-versus-host disease was 41% +/- 8% in the RCBT group and 37% +/- 6% in the UCBT group (P =.59). Kaplan-Meier estimates of 2-year event-free survival (EFS) after RCBT or UCBT were 39% +/- 8% and 30% +/- 7%, respectively (P =.19). In multivariate analysis, the most important factor influencing EFS was disease status at time of transplantation: good-risk patients had a 2-year EFS of 49% +/- 7% as compared to 8% +/- 5% in patients with more advanced disease (P =.0003, RR: 0.40, 95% CI: 0.24 to 0. 65). This was a consequence of both an increased 1-year transplant related mortality and a higher 2-year relapse rate in the poor-risk group (65% +/- 9% and 77% +/- 14%, respectively), as compared with good risk patients (34% +/- 6% and 31% +/- 9%, respectively). These data confirm that allogeneic CBT from either a related or an unrelated donor is a feasible procedure able to cure a significant proportion of children with acute leukemia, especially if transplanted in a favorable phase of disease.
authors.affiliation: Clinica Pediatrica, IRCCS Policlinico San Matteo, University of Pavia, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: V
authors.initials: V
authors.lastname: Rocha
authors.forename: C
authors.initials: C
authors.lastname: Chastang
authors.forename: W
authors.initials: W
authors.lastname: Arcese
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: M
authors.initials: M
authors.lastname: Abecasis
authors.forename: C
authors.initials: C
authors.lastname: Messina
authors.forename: J
authors.initials: J
authors.lastname: Ortega
authors.forename: I
authors.initials: I
authors.lastname: Badell-Serra
authors.forename: E
authors.initials: E
authors.lastname: Plouvier
authors.forename: G
authors.initials: G
authors.lastname: Souillet
authors.forename: J P
authors.initials: JP
authors.lastname: Jouet
authors.forename: R
authors.initials: R
authors.lastname: Pasquini
authors.forename: E
authors.initials: E
authors.lastname: Ferreira
authors.forename: F
authors.initials: F
authors.lastname: Garnier
authors.forename: E
authors.initials: E
authors.lastname: Gluckman
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000473:pathology / Q000628:therapy*; D008297:Male; D015999:Multivariate Analysis; D012008:Recurrence; D014184:Transplantation, Homologous; D016896:Treatment Outcome