title: An improved method for the measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma by stable isotope dilution gas chromatography/negative ion chemical ionization mass spectrometry.
abstract: An improved method for the quantitative measurement of the angiotensin-converting enzyme inhibitor lisinopril in human plasma is presented. The assay is based on gas chromatography/negative ion chemical ionization mass spectrometry. The method involves solid phase extraction on C18 sorbent and derivatization to the pentafluorobenzyl diester trifluoroacetamide derivatives.
authors.affiliation: University Childrens Hospital, Dept. of Biochemical Analysis and Mass Spectrometry, University of Graz, Austria.
authors.forename: H J
authors.initials: HJ
authors.lastname: Leis
authors.forename: G
authors.initials: G
authors.lastname: Fauler
authors.forename: G
authors.initials: G
authors.lastname: Raspotnig
authors.forename: W
authors.initials: W
authors.lastname: Windischhofer
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000097:blood* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D017706:Lisinopril / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D007202:Indicators and Reagents; D017706:Lisinopril