title: Magnetic resonance spectroscopy of ischemic heart disease.
abstract: An overview of the basic knowledge necessary to understand the procedure of Magnetic Resonance Spectroscopy of the myocardium and its most significant applications in the study of ischemic heart disease, is presented, with reference to the personal experience. The chemical shift phenomenon, the main techniques of spectroscopic localization and the general aspects of myocardial 31P and 1H Magnetic Resonance Spectroscopy, including proton decoupling and magnetization transfer, are illustrated. Postprocessing techniques before and after Fourier transform are mentioned. 31P Magnetic Resonance Spectroscopy allows the noninvasive assessment of the metabolism of high energy phosphates, PCr/ATP ratio in particular, in the in vivo myocardial tissue with significant applications in the diagnostic approach to ischemic patients with the support of provocative tests (dobutamine). 1H Magnetic Resonance Spectroscopy allows similar evaluations based on the peak of total creatinine.
authors.affiliation: Istituto di Radiologia, Università di Genova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Sardanelli
authors.forename: F
authors.initials: F
authors.lastname: Zandrino
authors.forename: G
authors.initials: G
authors.lastname: Molinari
authors.forename: S
authors.initials: S
authors.lastname: Cordone
authors.forename: L
authors.initials: L
authors.lastname: Delfino
authors.forename: F
authors.initials: F
authors.lastname: Levrero
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000318:Adrenergic beta-Agonists; D003404:Creatinine / Q000378:metabolism; D004280:Dobutamine; D005583:Fourier Analysis; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010759:Phosphorus Isotopes
chemical_list: D000318:Adrenergic beta-Agonists; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D004280:Dobutamine; D000244:Adenosine Diphosphate; D006859:Hydrogen; D000255:Adenosine Triphosphate; D003404:Creatinine