[Cerebral miliary granulomatosis with Histoplasma capsulatum in an HIV seronegative patient].
A 51 year old patient who worked in Africa for eight years, presented twelve years later a progressive ataxia associated with headaches. Neuroimaging studies done after a partial complex seizure demonstrated multiple supra and sub-tentorial cortical ring enhancing lesions. Histoplasma capsulatum histoplasmosis was found on histological examination of brain biopsy and confirmed by isolation of the fungus. Medical treatment with intravenous amphotericin B followed by oral itraconazole (400 mg per day) improved both clinical and radiological status. This observation of cerebral histoplasmosis is rather unusual for a seronegative HIV patient in a non endemic area.
Hadi
M
M
Service de Neurologie, Centre Hospitalier Universitaire Dupuytren, Limoges.
Boncoeur-Martel
M P
MP
Bouteille
B
B
Preux
P M
PM
Bernet-Bernady
P
P
Dumas
M
M
Vallat
J M
JM
Couratier
P
P
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D001921:Brain / Q000382:microbiology* / Q000473:pathology; D018450:Disease Progression; D018023:HIV Seronegativity; D006660:Histoplasmosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D000666:Amphotericin B