title: Related changes in sympathetic activity, cerebral blood flow and intracranial pressure, and effect of an alpha-blocker in experimental subarachnoid haemorrhage.
abstract: We investigated the changes in sympathetic nerve activity (SNA) and cerebral blood flow (CBF) with or without increase in intracranial pressure (ICP) in the acute stage of experimental subarachnoid haemorrhage (SAH). ICP was increased or controlled by rapid or slow injection of blood and saline, and the effect of an alpha-blocker, phentolamine, was also investigated in each condition. Following marked increase in ICP induced by rapid injection of blood or saline, increase in intracranial and general SNA and decrease in CBF were observed. Both changes were significantly decreased in magnitude by prior administration of phentolamine. When increase in ICP was not induced, by slow injection of blood, both SNA and CBF decreased, and these changes were alleviated by phentolamine. However, when increase in ICP was not induced by saline, neither SNA nor CBF significantly changed. These findings suggest that marked increase in ICP is the primary cause of the pathological changes occurring immediately after SAH, and that the decrease in CBF in mild SAH without increase in ICP is caused by blood itself. Administration of an alpha-blocker may be effective in improving the abnormal sympathetic nervous system induced by marked increase in ICP.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Furuichi
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: A
authors.initials: A
authors.lastname: Haji
authors.forename: R
authors.initials: R
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Nisijima
authors.forename: A
authors.initials: A
authors.lastname: Takaku
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001803:Blood Transfusion; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D007427:Intracranial Pressure / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D017783:Superior Cervical Ganglion / Q000187:drug effects / Q000503:physiopathology; D017779:Sympathetic Fibers, Postganglionic / Q000187:drug effects / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D010646:Phentolamine