Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease.
Bleomycin hydrolase (BH), a cysteine protease belonging to the papain superfamily, is one of the candidate beta secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation.
Namba
Y
Y
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ynanba-tky@umin.ac.jp
Ouchi
Y
Y
Takeda
A
A
Ueki
A
A
Ikeda
K
K
D000544:Alzheimer Disease / Q000201:enzymology* / Q000473:pathology; D016022:Case-Control Studies; D003546:Cysteine Endopeptidases / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D058225:Plaque, Amyloid / Q000201:enzymology*
D003546:Cysteine Endopeptidases; C031262:bleomycin hydrolase