Apoptosis: Silencing the death receptors.
Spontaneous signaling from death-domain-containing receptors can result in inappropriate cell death. An inhibitory protein has recently been identified, called silencer of death domains (SODD), that binds to the death domain of tumor necrosis factor receptor 1, thereby negatively regulating downstream signaling.
Tschopp
J
J
Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH - 1066, Epalinges, Switzerland. jurg.tschopp@ib.unil.ch
Martinon
F
F
Hofmann
K
K
D000595:Amino Acid Sequence; D017209:Apoptosis; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D002352:Carrier Proteins; D018124:Receptors, Tumor Necrosis Factor