title: Obesity affects expression of progesterone receptors and node metastasis of mammary carcinomas in postmenopausal women without a family history.
abstract: Possible relationships between risk factors, such as obesity and a family history of breast cancer, and prognostic factors of mammary carcinomas were investigated by examining the body mass index of patients and the expression of estrogen (ER) and progesterone receptors (PgR), c-erbB-2 and p53, grade of histology, size of tumors and nodal status of mammary carcinomas. There was no significant difference in the body mass index of premenopausal patients either with or without a family history. For postmenopausal patients, the body mass index was significantly low in patients with a family history compared with patients without a family history. In premenopausal patients with or without a family history and in postmenopausal patients with a family history, there was no significant difference in the body mass index regardless of the mammary carcinoma prognostic factor, such as expression of ER, PgR, c-erbB-2 and p53, grade of histology, size of tumors and nodal status. However, in postmenopausal patients without a family history, body mass index was significantly high for patients with mammary carcinomas that had PgR expression and node metastasis. These results suggest that obesity may affect the PgR status and nodal status of mammary carcinomas in postmenopausal patients without a family history.
authors.affiliation: Department of Pathology, Faculty of Medicine, Kagoshima University, Japan. yoshida@med4.kufm.kagoshima-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Honda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohi
authors.forename: Y
authors.initials: Y
authors.lastname: Umekita
authors.forename: T
authors.initials: T
authors.lastname: Takasaki
authors.forename: K
authors.initials: K
authors.lastname: Kuriwaki
authors.forename: I
authors.initials: I
authors.lastname: Ohyabu
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Ninomiya
authors.forename: S
authors.initials: S
authors.lastname: Akiba
authors.forename: S
authors.initials: S
authors.lastname: Nomura
authors.forename: Y
authors.initials: Y
authors.lastname: Sagara
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
mesh_terms: D015992:Body Mass Index; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D017698:Postmenopause; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D018570:Risk Assessment; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53