title: Respiratory impedance during positive expiratory airway pressure in patients with chronic obstructive pulmonary disease.
abstract: The effect of positive airway pressure (5.0 hPa) on airway impedance (Za) and tissue impedance (Zt) during the expiratory phase in chronic obstructive pulmonary disease (COPD) patients was evaluated using random noise oscillation and a body box method. The results were then compared with those obtained from normal subjects. In normal subjects, there was no significant difference between non-expiratory positive pressure (NPEP) and positive expiratory pressure (PEP) for the Zar (real part) and Zai (imaginary part) at 10 Hz (Zar NPEP: 2.14 +/- 0.76, PEP: 1.96 +/- 0.79; Zai NPEP: 1.42 +/- 0.66, PEP: 1.40 +/- 0.70 hPa l-1 s). However, in COPD patients, Zar decreased significantly and the Zai increased significantly during PEP as compared to the values during NPEP (Zar NPEP: 7.10 +/- 1.88, PEP: 5.97 +/- 1.67, P < 0.05; Zai NPEP: -4.10 +/- 2.27, PEP: -2.99 +/- 2.62 hPa l-1 s, P < 0.05). These results suggested that both central and peripheral airway resistance decreased during PEP in COPD patients. Tissue compliance (Ct) calculated from the Zt increased significantly during PEP as compared to during NPEP, in both normal subjects and in COPD patients (normal NPEP: 0.024 +/- 0.004, PEP: 0.021 +/- 0.003, P < 0.05; COPD NPEP: 0.024 +/- 0.004, PEP: 0.014 +/- 0.004 l hPa-1, P < 0.001). This may have been indicative of the stiffened chest wall during PEP.
authors.affiliation: Department of Physical Therapeutics, Kyoto University Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mishima
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: Y
authors.initials: Y
authors.lastname: Takubo
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Muro
authors.forename: Y
authors.initials: Y
authors.lastname: Oku
authors.forename: K
authors.initials: K
authors.lastname: Chin
authors.forename: M
authors.initials: M
authors.lastname: Ohi
mesh_terms: D000328:Adult; D000403:Airway Resistance; D004548:Elasticity; D006801:Humans; D008168:Lung / Q000502:physiology; D008173:Lung Diseases, Obstructive / Q000503:physiopathology* / Q000628:therapy*; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012016:Reference Values; D012129:Respiratory Function Tests; D012815:Signal Processing, Computer-Assisted