title: Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans.
abstract: Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycoplasma fermentans were demonstrated to trigger the transcription of intercellular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gingival tissue and to induce its cell surface expression by a mechanism distinct from that of Escherichia coli lipopolysaccharide. The lipid moiety of the lipoproteins was suggested to play a key role in the expression of the activity.
authors.affiliation: Departments of Oral Bacteriology, Hokkaido University School of Dentistry, Kita-Ku, Sapporo 060-8586, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Dong
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Sawa
authors.forename: A
authors.initials: A
authors.lastname: Hasebe
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D005881:Gingiva / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000235:genetics*; D008074:Lipoproteins / Q000378:metabolism; D009174:Mycoplasma / Q000502:physiology*; D016858:Mycoplasma fermentans / Q000502:physiology*; D012333:RNA, Messenger; D015533:Transcriptional Activation; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D012333:RNA, Messenger; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1