title: Synthesis and antiproliferative activity of some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]pyridines.
abstract: Some N-sulphonated-2-substituted benzimidazoles and imidazo[4,5-b]-pyridines were synthesized and tested in vitro for antiviral and antiproliferative activity. None of the compounds had antiviral properties. However, three of them inhibited the proliferation of leukaemia and lymphoma cell lines at micromolar concentrations. The maximum potency of antiproliferative activity is correlated with the presence of an ethylenic spacer between the two heterocycles.
authors.affiliation: Department of Pharmaceutical Science, University of Bologna, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Garuti
authors.forename: L
authors.initials: L
authors.lastname: Varoli
authors.forename: C
authors.initials: C
authors.lastname: Cermelli
authors.forename: G
authors.initials: G
authors.lastname: Baggio
authors.forename: L
authors.initials: L
authors.lastname: Lupo
authors.forename: M
authors.initials: M
authors.lastname: Malagoli
authors.forename: M
authors.initials: M
authors.lastname: Castelli
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001557:Benzenesulfonates; D001562:Benzimidazoles; D011725:Pyridines