title: [Adrenal tumors found by chance. Surgical treatment or follow-up?].
abstract: 206 case records of the patients treated from 1985 to 1998 for various diseases of the adrenal glands were analyzed. In 39 (18.9%) patients tumors were chance finding at ultrasound examination or computer tomography of the abdominal cavity and retroabdominal space. 25 patients from this group were operated on, 14 patients were not operated and were followed up from 1 month to 7 years. All the patients underwent complex examination including analysis of the complaints, anamnesis and physical examination data, hormonal status examination (ACTH, hydrocortisone, 11-oxycorticosteroids, 17-ketosteroids, aldosterone, renin, adrenalin, noradrenalin, vanillyl-mandelic acid), device methods of examination USE, CT, MRT, superselective phlebography with separate catheterization of adrenal veins and blood intake per floor, fine needle aspiration biopsy under ultrasound control. Comparison of the results of complex clinical examination with morphological data of removed adrenal glands was carried out retrospectively. Arteriography and superselective phlebography with separate catheterization of adrenal veins and per floor taking of blood samples, performed in 36 patients, enabled not only to supplement and define more exactly the other methods of topical diagnosis, but also to asses objectively functional actively of the affected and contralateral adrenal. Despite the fact that during the study of hormonal level in peripheral blood of patients it was normal analysis of the data obtained by superselective phlebography of adrenal veins and per floor taking of blood samples showed significant increase in hormones level in blood of all operated patients. Comparison of the data of superselective phlebography with separate catheterization of adrenal veins and per floor taking of blood samples and clinical picture of the disease made it possible to suggest the presence of preclinical (subclinical) Cushing or Conn syndrome. Operative treatment was not indicated in the absence of hormonal activity of the tumor (i.e. preclinical syndromes by Icenko-Cushing, Conn, pheochromocytoma, the virilizing and feminizing tumors), tumors of small size (less than 3 cm), in absence of malignant growth features confirmed by complex instrumental examination (USE, CT, MRT, fine-needle aspiration biopsy under US control, superselective phlebography with per floor taking of blood samples). Such patients were reexamined in 6 months. During the follow up period no changes of tumor size, homogeneity, hormonal status were revealed.
authors.forename: P S
authors.initials: PS
authors.lastname: Vetshev
authors.forename: O S
authors.initials: OS
authors.lastname: Shkrob
authors.forename: S A
authors.initials: SA
authors.lastname: Kondrashin
authors.forename: A N
authors.initials: AN
authors.lastname: Lotov
authors.forename: L I
authors.initials: LI
authors.lastname: Ippolitov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Kulezneva
authors.forename: M T
authors.initials: MT
authors.lastname: Minnibaev
authors.forename: A N
authors.initials: AN
authors.lastname: Pavlova
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery*; D000315:Adrenalectomy; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D003657:Decision Making; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D014408:Biomarkers, Tumor