[Cross-talk between signal transduction pathways in the cell-- the role of G proteins in these processes].
Family of heterotrimeric G proteins plays an essential role in transducing signals across the plasma membrane in animal cells. Members of G protein family have been grouped into four subtypes: Gs, Gi, Gq and G12. A cross-talk between Gi- and Gq-; Gs- and Gi-; and Gs- and Gi-coupled receptors are presented. Interactions between G protein coupled receptors and receptor tyrosine kinases and between G12 protein and the small molecular weight guanosine trisphosphate protein Rho are also described.
Barańska
J
J
Zakład Neurobiologii Molekularnej i Komórkowej Instytutu Biologii Doświadczalnej PAN im. M. Nenckiego w Warszawie.
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology*; D012234:Rho Factor / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D012234:Rho Factor; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins