Lung function in infants with chronic pulmonary disease after severe adenoviral illness.
OBJECTIVE
To evaluate pulmonary function and bronchodilator responses in young children with chronic pulmonary disease (CPD) after a severe adenoviral lower respiratory tract infection.


METHODS
Pulmonary function tests were performed in 13 patients (mean age, 1.32 +/- 0.8 years) with CPD and were compared with a control group of 13 healthy infants (mean age, 1.16 +/- 0.4 years).


RESULTS
Respiratory rate, peak tidal expiratory flow (PTEF), PTEF/tidal volume, absolute time up to PTEF, time percentage to PTEF, volume percentage for PTEF, and compliance and resistance of the respiratory system were significantly affected in the CPD group. Similarly, maximal flow at functional residual capacity (V'maxFRC) was 56.0 +/- 42 mL/s and 373 +/- 107 mL/s in the CPD and control groups, respectively (P =.001). No within-group differences with baseline values or between-group differences were noted in response to treatment with ipratropium bromide or albuterol.


CONCLUSIONS
Young children with CPD caused by adenovirus have pulmonary function changes characterized by severe obstruction and diminished lung distensibility not responsive to the administration of inhaled ipratropium bromide or albuterol.
Teper
A M
AM
Respiratory Center, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
Kofman
C D
CD
Maffey
A F
AF
Vidaurreta
S M
SM
D000257:Adenoviridae Infections / Q000150:complications*; D000420:Albuterol / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007223:Infant; D009241:Ipratropium / Q000627:therapeutic use*; D008171:Lung Diseases / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000150:complications*
D001993:Bronchodilator Agents; D009241:Ipratropium; D000420:Albuterol