title: Fatal anaphylactic shock during a fluorescein angiography.
abstract: The Authors describe an extremely rare fatal case (sixth case in the literature) of anaphylactic shock following a fluorescein angiography. This is the first report in which the diagnosis of anaphylactic reaction to the dye was made through laboratory analyses. The diagnosis of fatal shock due to sodium fluorescein was made based on clinical, laboratory and immunohistochemical data. Mast-cell tryptase was dosed in serum and a pulmonary immunohistochemical evaluation was performed. Tryptase, a neutral protease of human mast-cells is a potentially important indicator of mast-cell involvement in anaphylactic events.
authors.affiliation: Department of Forensic Sciences, University of Siena, Italy. vfinesc@tin.it
authors.forename: V
authors.initials: V
authors.lastname: Fineschi
authors.forename: G
authors.initials: G
authors.lastname: Monasterolo
authors.forename: R
authors.initials: R
authors.lastname: Rosi
authors.forename: E
authors.initials: E
authors.lastname: Turillazzi
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis* / Q000378:metabolism; D001344:Autopsy / Q000379:methods*; D002423:Cause of Death; D053818:Chymases; D003287:Contrast Media / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D019793:Fluorescein / Q000009:adverse effects*; D005451:Fluorescein Angiography / Q000009:adverse effects*; D006801:Humans; D007150:Immunohistochemistry; D008407:Mast Cells / Q000201:enzymology; D012697:Serine Endopeptidases / Q000032:analysis / Q000097:blood; D053802:Tryptases
chemical_list: D003287:Contrast Media; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; D019793:Fluorescein