Leukocyte adhesion: High-speed cells with ABS.
In order to decide where to exit blood vessels and enter tissues, leukocytes roll along endothelial surfaces. Recent studies suggest that an 'automatic braking system' (ABS), involving selectin cell-adhesion molecules, enables leukocytes to roll at a fairly constant velocity despite large variations in blood flow rate.
van der Merwe
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PA
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. anton.vandermerwe@path.ox.ac.uk
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D007962:Leukocytes / Q000502:physiology*; D008024:Ligands; D019087:Selectins / Q000378:metabolism
D008024:Ligands; D019087:Selectins