Low-molecular-weight anti-HIV-1 peptides from the amino-terminal sequence of RANTES: possible lead compounds for coreceptor-directed anti-HIV-1 agents.
A series of small peptides corresponding to the amino-terminal sequence of RANTES were synthesized, and their anti-HIV-1 activity was evaluated. Pentapeptides, H-(10Ala-RANTES 6-10)-OH and Ac-(10Ala-RANTES 6-10)-NH2, were the smallest anti-HIV-1 peptides so far developed, and would be potentially important lead compounds for coreceptor-directed anti-HIV-1 drugs.
Nishiyama
Y
Y
Department of Industrial Chemistry, Faculty of Engineering, Seikei University, Tokyo, Japan. nishi@ch.seikei.ac.jp
Murakami
T
T
Kurita
K
K
Yamamoto
N
N
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D018946:Chemokine CCL5 / Q000737:chemistry*; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*
D019380:Anti-HIV Agents; D018946:Chemokine CCL5; D010446:Peptide Fragments