title: Identifying inner retinal contributions to the human multifocal ERG.
abstract: Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.
authors.affiliation: Department of Psychology, Columbia University, New York, NY 10027, USA. don@psych.columbia.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Hood
authors.forename: V
authors.initials: V
authors.lastname: Greenstein
authors.forename: L
authors.initials: L
authors.lastname: Frishman
authors.forename: K
authors.initials: K
authors.lastname: Holopigian
authors.forename: S
authors.initials: S
authors.lastname: Viswanathan
authors.forename: W
authors.initials: W
authors.lastname: Seiple
authors.forename: J
authors.initials: J
authors.lastname: Ahmed
authors.forename: J G
authors.initials: JG
authors.lastname: Robson
mesh_terms: D000328:Adult; D000818:Animals; D003930:Diabetic Retinopathy / Q000503:physiopathology; D004596:Electroretinography / Q000187:drug effects*; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006801:Humans; D008253:Macaca mulatta; D008875:Middle Aged; D016202:N-Methylaspartate / Q000494:pharmacology; D010364:Pattern Recognition, Visual / Q000502:physiology; D012160:Retina / Q000502:physiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin; D016202:N-Methylaspartate