title: Renal insufficiency and altered postoperative risk in carotid endarterectomy.
abstract: OBJECTIVE
  Higher complication rates have been reported in patients with renal insufficiency (RI) undergoing peripheral vascular surgery. Little attention has been paid specifically to carotid endarterectomy (CEA) in patients with RI where the risk/benefit considerations are very sensitive to small increases in postoperative complications.
  
  
  METHODS
  One thousand one consecutive CEAs performed since 1990 were reviewed from our vascular registry, and 73 CEAs on patients with RI were identified. For comparison, two groups were established: group I (n = 928), normal renal function (creatinine level, <1.5 mg/dL); and group II (n = 73), RI (creatinine level, >/=1.5 mg/dL).
  
  
  RESULTS
  Differences in the nonfatal stroke rates and combined stroke and death rates were statistically significant (P <.02) between the groups: group I (1. 08% and 1.18%) and group II (5.56% and 6.94%) respectively. Both groups were similar in regard to operative indications. In addition with the comparison of group I to group II, there was a statistically significant increase in hematoma rate, 1.61% versus 12. 5% ( P <.001), total cardiac morbidity, 1.72% versus 6.94% (P =.003), and total complications, 6.24% versus 36.1% (P =.001). Multivariate analysis demonstrated pre-existing RI to be the only significant predictor for perioperative stroke and hematoma.
  
  
  CONCLUSIONS
  Patients with preoperative RI are at a higher, but not prohibitive, risk for stroke and death after CEA than patients with normal renal function. They are also at risk for hematoma formation, cardiac morbidity, and overall complications. Care in selection of these patients for CEA must be emphasized.
authors.affiliation: Department of Vascular Surgery, Beth Israel Deaconess Medical Center, West Campus, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Hamdan
authors.forename: F B
authors.initials: FB
authors.lastname: Pomposelli
authors.forename: G W
authors.initials: GW
authors.lastname: Gibbons
authors.forename: D R
authors.initials: DR
authors.lastname: Campbell
authors.forename: F W
authors.initials: FW
authors.lastname: LoGerfo
mesh_terms: D000368:Aged; D016893:Carotid Stenosis / Q000097:blood / Q000150:complications / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D016894:Endarterectomy, Carotid / Q000009:adverse effects*; D005260:Female; D006331:Heart Diseases / Q000209:etiology; D006406:Hematoma / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D008297:Male; D012306:Risk; D020521:Stroke / Q000209:etiology
chemical_list: D003404:Creatinine