GPi firing rate modification during beginning-of-dose motor deterioration following acute administration of apomorphine.
We present a patient with clinically evident beginning-of-dose motor deterioration who had undergone posteroventral pallidotomy. This patient underwent an intrasurgical apomorphine test followed by single cell recording of the internal globus pallidus (GPi) to determine changes in GPi firing rate during the occurrence of such phenomenon. A significant increase in GPi firing rate coincident with worsening of patient disabilities prior to improvement was found. This finding suggests that beginning-of-dose motor deterioration may be mediated by enhanced thalamic inhibition.
Merello
M
M
Movement Disorders Section, Raul Carrea Institute for Neurological Research (FLENI), Buenos Aires, Argentina.
Lees
A J
AJ
Balej
J
J
Cammarota
A
A
Leiguarda
R
R
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D001058:Apomorphine / Q000494:pharmacology* / Q000627:therapeutic use; D001479:Basal Ganglia / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005917:Globus Pallidus / Q000187:drug effects* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009474:Neurons / Q000187:drug effects*; D010300:Parkinson Disease / Q000188:drug therapy; D011597:Psychomotor Performance / Q000187:drug effects*; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000187:drug effects; D013997:Time Factors
D018491:Dopamine Agonists; D001058:Apomorphine