title: Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
abstract: Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.
authors.affiliation: Department of Organic Chemistry, Lajos Kossuth University, Debrecen, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Osz
authors.forename: L
authors.initials: L
authors.lastname: Somsák
authors.forename: L
authors.initials: L
authors.lastname: Szilágyi
authors.forename: L
authors.initials: L
authors.lastname: Kovács
authors.forename: T
authors.initials: T
authors.lastname: Docsa
authors.forename: B
authors.initials: B
authors.lastname: Tóth
authors.forename: P
authors.initials: P
authors.lastname: Gergely
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D011817:Rabbits
chemical_list: D004791:Enzyme Inhibitors; D006005:Phosphorylases