Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system.
The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.
Coburn
J
J
Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. jcoburn_bor@opal.tufts.edu
Frank
D W
DW
D016475:3T3 Cells; D036002:ADP Ribose Transferases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008805:Mice, Inbred A; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000472:pathogenicity*; D014407:Tumor Cells, Cultured
D036002:ADP Ribose Transferases