Cross-sensitivity and the anticonvulsant hypersensitivity syndrome.
The anticonvulsant hypersensitivity syndrome is a rare complication that occurs with the use of antiepileptic medications. Although phenytoin is the most common culprit, carbamazepine and phenobarbital are known to cause a similar reaction. A familial occurrence has been reported. We present a case of the anticonvulsant hypersensitivity syndrome to emphasize the importance of recognizing the multiple clinical components of the syndrome and to raise awareness of the cross-sensitivity among anticonvulsants metabolized via arene oxide metabolites.
Moss
D M
DM
Department of Emergency Medicine, University of Southern California School of Medicine, Los Angeles, USA.
Rudis
M
M
Henderson
S O
SO
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D004342:Drug Hypersensitivity; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects*; D013577:Syndrome
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital