[Functional status of the interferon system in inapparent and clinical infection with hepatitis B and C viruses].
In vitro production of alpha- and gamma-interferon (IF) by peripheral blood cells and the concentrations of serum IF were studied in 47 intravenous drug users infected with hepatitides viruses B and C (HBV and HCV) and in 50 inpatients with verified diagnosis of hepatitides B or C, 16 of these narcomaniacs. In acute disease, the capacity of cells to produce alpha- and gamma-IF was suppressed, while the concentration of IF circulating in the blood was increased. Suppression of alpha-IF production was more expressed in patients with hepatitides C and B+C than in those with hepatitis B. HBV and/or HCV infection without clinical signs of disease did not affect the production of IF. In narcomaniacs using opiates and ephedrine drugs for up to 5 years IF system did not depend on drug addiction.
Priĭmiagi
L S
LS
Kremerman
I B
IB
Tefanov
V T
VT
Tallo
T G
TG
Osadchaia
G S
GS
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006526:Hepatitis C / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis* / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015819:Substance Abuse, Intravenous / Q000097:blood* / Q000150:complications
D015415:Biomarkers; D016898:Interferon-alpha; D007371:Interferon-gamma