title: Sleep of children with enuresis: a polysomnographic study.
abstract: OBJECTIVE
  To evaluate relationships between bladder voiding and sleep in children with enuresis.
  
  
  METHODS
  Polysomnographic recordings were obtained from 25 children, aged 7 to 17 years, with monosymptomatic nocturnal enuresis. During 52 recorded nights, 37 enuretic events were detected. Responders (n = 7) and nonresponders (n = 16) to desmopressin treatment were compared.
  
  
  RESULTS
  The mean latency between sleep onset and the first bladder voiding was 3 hours 20 minutes (SD = 2 hours 5 minutes). The number of voidings were 19, 7, 10, and 1 occurring during stages 2, 3, and 4, and rapid-eye movement sleep, respectively. Desmopressin responders were found to void during the early or late part of the night, whereas the voidings of the nonresponders were dispersed evenly throughout the night (chi2 = 8.09).
  
  
  CONCLUSIONS
  The enuretic event is a predominantly non-rapid eye movement sleep phenomenon. Responders and nonresponders to desmopressin treatment void during different parts of the night.
authors.affiliation: Department of Pediatrics, Uppsala, Sweden. tryggve.neveus@pediatrik.uu.se
authors.forename: T
authors.initials: T
authors.lastname: Nevéus
authors.forename: A
authors.initials: A
authors.lastname: Stenberg
authors.forename: G
authors.initials: G
authors.lastname: Läckgren
authors.forename: T
authors.initials: T
authors.lastname: Tuvemo
authors.forename: J
authors.initials: J
authors.lastname: Hetta
mesh_terms: D000293:Adolescent; D002648:Child; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004775:Enuresis / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography / Q000379:methods*; D012076:Renal Agents / Q000627:therapeutic use; D012895:Sleep, REM / Q000502:physiology*; D016896:Treatment Outcome; D014563:Urodynamics / Q000502:physiology
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin