Effect of prostacyclin on gastric mucosal RNA-content in the rat.
We investigated changes in gastric (antral and fundic) mucosal RNA contents in single-dose and in long-term (10 weeks) treatment of rats with receiving oral graded doses of prostacyclin. Long-term application of prostacyclin evoked no significant changes, while in the single-dose experiments there was a dose-dependent elevation in RNA-content in both parts of the gastric mucosa. The results are interpreted as convincing signs of the gastro-protective effect of prostacyclin.
Balint
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Department of Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D011706:Pyloric Antrum / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000959:Antihypertensive Agents; D012313:RNA; D011464:Epoprostenol