title: Exposure to polycyclic aromatic hydrocarbons and genotoxic effects on nonsmoking Swedish road pavement workers.
abstract: OBJECTIVE
  The objective of this study was to investigate exposure to polycyclic aromatic hydrocarbons (PAH) from asphalt fumes among Swedish road pavement workers and determine whether any effects could be detected with genotoxic tests.
  
  
  METHODS
  The study included 28 nonsmoking road pavers and 30 nonsmoking referents. The concentration of PAH was determined in the breathing zone of the road pavers. 1-Hydroxypyrene was analyzed before and after shifts of asphalt work and during the afternoon for referents. Sister chromatid exchanges (SCE) and micronuclei (MN) were determined in peripheral lymphocytes.
  
  
  RESULTS
  Several 3- or 4-ring PAH were found, and the analysis indicated that they occurred in bitumen fumes rather than in traffic fumes. The average total concentration of PAH was 2.3 (range 0.2-23.8) microg/m3. The concentration of 1-hydroxypyrene in urine was higher for the road pavers than for the referents, but there was no significant difference between the pre- and postshift values of the road pavers. The road pavers had no significant increase in SCE or MN.
  
  
  CONCLUSIONS
  The study showed that Swedish road pavers have an increased exposure to PAH from bitumen fumes, but no genotoxic effects could be detected by SCE or MN tests.
authors.affiliation: Department of Occupational and Environmental Medicine, University Hospital, Umeå, Sweden. Bengt.Jarvholm@envmed.umu.se
authors.forename: B
authors.initials: B
authors.lastname: Järvholm
authors.forename: G
authors.initials: G
authors.lastname: Nordström
authors.forename: B
authors.initials: B
authors.lastname: Högstedt
authors.forename: J O
authors.initials: JO
authors.lastname: Levin
authors.forename: J
authors.initials: J
authors.lastname: Wahlström
authors.forename: C
authors.initials: C
authors.lastname: Ostman
authors.forename: C
authors.initials: C
authors.lastname: Bergendahl
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis* / Q000378:metabolism; D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring / Q000379:methods; D005740:Gases; D006801:Humans; D006838:Hydrocarbons / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis* / Q000378:metabolism; D016273:Occupational Exposure / Q000032:analysis*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D013548:Sweden; D014186:Transportation
chemical_list: D000395:Air Pollutants, Occupational; D002273:Carcinogens; D005740:Gases; D006838:Hydrocarbons; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; C006647:asphalt