title: Angioscotoma detection with fundus-oriented perimetry. A study with dark and bright stimuli of different sizes.
abstract: Fundus-oriented perimetry (FOP) was used to evaluate the effectiveness of different-sized bright and dark stimuli in detecting and quantitatively measuring angioscotoma. The foveolas and optic disks of digitized fundus images were aligned with their psychophysical counterparts to construct individual grids of perimetric stimuli. Each grid included a linear set of test point locations crossing a retinal vessel. Angioscotomas immediately became visible in nine of 13 healthy normal volunteers tested with FOP. Additional mathematical processing of local loss of differential light sensitivity (dls) disclosed an angioscotoma for at least one stimulus condition in all persons tested. The angioscomas were usually deeper for small (12) targets than for large (32') ones. On the other hand, the overall noise at dls thresholds was generally higher for small than for large stimuli regardless of whether the stimuli were bright or dark. No noteworthy differences were found in detection rates or signal-to-noise ratios under different stimulus conditions (dark/bright/small/large). FOP permits the individual arrangement of stimuli for specific morphological conditions and is thus capable of detecting even minute visual field defects such as angioscotomas.
authors.affiliation: University Eye Hospital, Dept. II, Tübingen, Germany. ulrich.schiefer@uni-tuebingen.de
authors.forename: U
authors.initials: U
authors.lastname: Schiefer
authors.forename: N
authors.initials: N
authors.lastname: Benda
authors.forename: T J
authors.initials: TJ
authors.lastname: Dietrich
authors.forename: B
authors.initials: B
authors.lastname: Selig
authors.forename: C
authors.initials: C
authors.lastname: Hofmann
authors.forename: J
authors.initials: J
authors.lastname: Schiller
mesh_terms: D000328:Adult; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D008027:Light; D008297:Male; D008433:Mathematics; D011601:Psychophysics; D012171:Retinal Vessels; D012607:Scotoma / Q000175:diagnosis*; D012684:Sensory Thresholds / Q000502:physiology; D058609:Visual Field Tests