Melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine genes incorporated into an African green monkey simian cytomegalovirus-derived stealth virus.
DNA isolated from the culture of an African green monkey simian cytomegalovirus (SCMV)-derived stealth virus has been cloned. A region of the virus that contains genes coding proteins homologous to the UL141, UL144, and UL145 proteins of human cytomegalovirus has recombined with cellular sequences encoding several distinct copies of the melanoma growth stimulatory activity (MGSA/GRO-alpha) chemokine gene. This finding illustrates the capacity of stealth viruses to capture, amplify, and mutate genes with potential oncogenic activity. The lack of introns in the assimilated cellular genes indicates a role for reverse transcription in the assembly of stealth viruses.
Martin
W J
WJ
Center for Complex Infectious Diseases, Rosemead, California 91770, USA.
D000595:Amino Acid Sequence; D000818:Animals; D054360:Chemokine CXCL1; D019743:Chemokines, CXC / Q000235:genetics*; D002630:Chemotactic Factors / Q000235:genetics*; D002522:Chlorocebus aethiops; D003587:Cytomegalovirus / Q000235:genetics*; D005822:Genetic Vectors; D006133:Growth Substances / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014763:Viral Matrix Proteins / Q000235:genetics*
C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D014763:Viral Matrix Proteins