I-type lectins in the nervous system.
The number of animal lectins, basically defined upon their interaction with specific carbohydrate structures, is growing considerably during the last few years. Among these proteins the recently identified subfamily of I-type lectins consists of mainly transmembranous glycoproteins belonging to the immunoglobulin superfamily. Most of the I-type lectins participate in cell adhesion events, as are the different sialoadhesins recognizing sialylated glycan structures, which represent the best characterized subgroup. I-type lectins are abundant in the nervous system and have been implicated in a number of morphogenetic processes as fundamental as axon growth, myelin formation and growth factor signaling. In the present review, we summarize the structural and functional properties of I-type lectins expressed in neural tissues with a main focus on the sialoadhesin myelin-associated glycoprotein, the neural cell adhesion molecule and the fibroblast growth factor receptors.
Probstmeier
R
R
Department of Biochemistry, Institute for Animal Anatomy and Physiology, University of Bonn, Germany.
Pesheva
P
P
D000818:Animals; D002448:Cell Adhesion; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D018993:Myelin P0 Protein / Q000737:chemistry / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000737:chemistry / Q000378:metabolism; D009420:Nervous System / Q000166:cytology* / Q000378:metabolism; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry / Q000378:metabolism; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry / Q000378:metabolism; D011971:Receptors, Immunologic / Q000737:chemistry / Q000378:metabolism; D063267:Sialic Acid Binding Ig-like Lectin 1; D015398:Signal Transduction
D037102:Lectins; D008562:Membrane Glycoproteins; D018993:Myelin P0 Protein; D018992:Myelin-Associated Glycoprotein; D019006:Neural Cell Adhesion Molecules; D011509:Proteoglycans; D017468:Receptors, Fibroblast Growth Factor; D011971:Receptors, Immunologic; D063267:Sialic Acid Binding Ig-like Lectin 1