title: Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism.
abstract: Brain tissue of 50 patients with morphological confirmed Parkinson's disease (PD), blood samples from 149 patients with clinical parkinsonism and from 96 healthy control subjects were collected. Apolipoprotein-E (apo E) and cytochrome P450 2D6 (CYP2D6) genotyping were performed by PCR followed by restriction fragment analysis. A significantly higher allele frequency of CYP2D6*4 was found in patients with PD (35%) but not with parkinsonism (14.1%) compared to control subjects (19.8%). The combined alleles frequency of CYP2D6*3 + apoE4 was significantly higher not only in the PD group (33.3%) but also in patients with parkinsonism (22.3%) compared to control subjects (1.6%). These results suggest that there is a substantial overlap not only in the clinical manifestation but also in the genetic risk factors between Parkinson's and Alzheimer's diseases.
authors.affiliation: Department of Clinical Chemistry, Medical Spectrum Twente, Hospital Group, Enschede, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Bon
authors.forename: E N
authors.initials: EN
authors.lastname: Jansen Steur
authors.forename: R A
authors.initials: RA
authors.lastname: de Vos
authors.forename: I
authors.initials: I
authors.lastname: Vermes
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D018450:Disease Progression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D003577:Cytochrome P-450 Enzyme System; D019389:Cytochrome P-450 CYP2D6