Late-type allergy to the X-ray contrast medium Solutrast (iopamidol).
In the past few years, there have been an increasing number of publications on delayed intolerance reactions, including rashes, following the use of X-ray contrast media. We report a patient in whom infiltrated erythema of the face and generalized maculopapular rashes occurred on 2 occasions, within 1 day, following the use of the X-ray contrast medium Solutrast (iopamidol) for coronary angiography. The allergological investigations for clarification included prick tests and patch tests using a series of contrast media, as well as individual intravenous provocation tests. We found the cause to be a late-type allergy to the active substance iopamidol contained in the contrast medium Solutrast. We found a concomitant cross-reactivity to the contrast media iopromid and iomeprol. All 3 contrast media represent the monomeric, non-ionic type.
Gall
H
H
Department of Dermatology, University of Ulm, Germany.
Pillekamp
H
H
Peter
R U
RU
D000485:Allergens / Q000009:adverse effects; D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry; D005148:Facial Dermatoses / Q000139:chemically induced*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D007479:Iopamidol / Q000009:adverse effects* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
D000485:Allergens; D003287:Contrast Media; D007479:Iopamidol