Microporous membrane drug delivery system for indomethacin.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of rheumatoid arthritis for more than a decade. The high incidence and severity of side effects, which are dose-related and associated with long-term administration, have limited its use. This has led to the search for new delivery systems which can overcome the side effects by controlling the drug release. In this study, Indomethacin Extended Release Formulation was developed by pelletization using the method of extrusion/spheronization. The drug containing pellets were further coated to achieve the required release profile as per USP. Coating systems developed on the principle of microporous membrane drug delivery using soluble salt gave the best results.
Elchidana
P A
PA
C.U. Shah College of Pharmacy, Sir Vithaldas Vidyavihar, Juhu Campus, Santacruz (W), Mumbai 400 049, India.
Deshpande
S G
SG
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004343:Drug Implants; D004355:Drug Stability; D007213:Indomethacin / Q000008:administration & dosage*; D008567:Membranes, Artificial; D016062:Porosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004343:Drug Implants; D008567:Membranes, Artificial; D007213:Indomethacin