title: Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin.
abstract: The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.
authors.affiliation: Laboratoire de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Doit
authors.forename: C
authors.initials: C
authors.lastname: Loukil
authors.forename: F
authors.initials: F
authors.lastname: Fitoussi
authors.forename: P
authors.initials: P
authors.lastname: Geslin
authors.forename: E
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D016172:DNA Fingerprinting; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D012150:Polymorphism, Restriction Fragment Length; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics
chemical_list: D010406:Penicillins; D000658:Amoxicillin