Effects of propranolol on the pharmacokinetics of cyclosporine after intravenous and oral administration to control rats and rats with uranyl nitrate-induced acute renal failure.
Effects of propranolol on the pharmacokinetics of cyclosporine were investigated after intravenous and oral administration of the drugs to control rats and rats with uranyl nitrate-induced acute renal failure (U-ARF). Effects of intravenous propranolol, 3 mg/kg, on the pharmacokinetics of intravenous cyclosporine, 3 and 30 mg/kg, to control rats, and 30 mg/kg, to rats with U-ARF seemed to be negligible. However, the effects of orally administered propranolol, 10 mg/kg, on the area under the blood concentration-time curve (AUC) of oral cyclosporine were significant after oral administration of cyclosporine, 10 and 100 mg/kg, to control rats. For example, the AUC of cyclosporine increased significantly (33.1 versus 24.7 microg h/ml) at cyclosporine oral dose of 10 mg/kg, however, the value decreased significantly (167 versus 235 microg h/ml) at cyclosporine oral dose of 100 mg/kg. Effects of orally administered propranolol, 10 mg/kg, on the pharmacokinetics of orally administered cyclosporine, 100 mg/kg, seemed to be negligible in rats with U-ARF.
Lee
Y H
YH
College of Pharmacy, Ewha Womans University, Seoul, South Korea.
Ku
Y S
YS
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001659:Biliary Tract / Q000378:metabolism; D001806:Blood Urea Nitrogen; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014502:Uranyl Nitrate / Q000633:toxicity
D000319:Adrenergic beta-Antagonists; D007166:Immunosuppressive Agents; D014502:Uranyl Nitrate; D016572:Cyclosporine; D011433:Propranolol