title: Primary biliary cirrhosis associated with painless thyroiditis.
abstract: A case of anti-mitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) associated with painless thyroiditis is reported in a 47-year-old woman who diagnosed as PBC based on her elevated serum gamma-glutamyl transpeptidase and immunoglobulin M levels, as well as histological findings of destroyed bile ducts surrounded by mononuclear infiltrates in the biopsied liver. She was negative for AMA and had a depressed level of thyroid-stimulating hormone accompanied by increased free thyrosine, thyroxine and triiodothyronine levels and low titers of anti-microsomal and anti-thyroid peroxidase antibodies. Her thyroid disorder corresponded with painless thyroiditis. An association between PBC and hyperthyroidism is rare. Furthermore, an association between AMA-negative PBC and hyperthyroidism due to painless thyroiditis has not previously been reported.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ohira
authors.forename: H
authors.initials: H
authors.lastname: Orikasa
authors.forename: J
authors.initials: J
authors.lastname: Shinzawa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Tojo
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications / Q000276:immunology; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000097:blood; D007453:Iodide Peroxidase / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology; D010146:Pain / Q000150:complications; D013963:Thyroid Hormones / Q000097:blood; D013966:Thyroiditis / Q000097:blood / Q000150:complications* / Q000276:immunology; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D013963:Thyroid Hormones; D007453:Iodide Peroxidase; D005723:gamma-Glutamyltransferase