T-cell prolymphocytic leukemia with a novel translocation (6;11)(q21;q23).
T-cell prolymphocytic leukemia (T-PLL) is an uncommon chronic lymphoproliferative disorder characterized by lymphadenopathy, splenomegaly, and lymphocytosis. The leukemic cells have the appearance of prolymphocytes and usually an immunophenotype of T-helper cells (CD3+ CD4+ CD8-). Inv(14q), del(11q), i(8q), and rearranged Xq28 are the commonest nonrandom chromosomal abnormalities in T-PLL. Recently, it has been shown that the ataxia-telangiectasia mutated (ATM) gene located at 11q23 is often deleted in T-PLL, suggesting a tumor suppressor role of the ATM gene on tumorigenesis of T-PLL. We report a case of T-PLL with t(6;11)(q21;q23) as the sole chromosomal abnormality and suggest that the cytogenetically identified translocation also implicates the ATM gene.
Wong
K F
KF
Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China.
Chan
J K
JK
Sin
V C
VC
D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D001706:Biopsy; D002880:Chromosomes, Human, Pair 11; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D015463:Leukemia, Prolymphocytic / Q000097:blood / Q000235:genetics; D015461:Leukemia, Prolymphocytic, T-Cell / Q000097:blood / Q000235:genetics*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D009333:Neck; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic
D015703:Antigens, CD