title: Effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum.
abstract: The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.
authors.affiliation: Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan. resp@med.kawasaki-m.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Niki
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Tamada
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: N
authors.initials: N
authors.lastname: Miyashita
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: H
authors.initials: H
authors.lastname: Sekino
authors.forename: O
authors.initials: O
authors.lastname: Matsuoka
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013806:Theophylline; C106426:olamufloxacin