Recent progress in biotechnology of Mexican medicinal plants.
Based on traditional medicinal knowledge, it was possible to identify the plant species Solanum chrysotrichum as the source of a new antimycotic agent designated SC-1. Cell suspension batch cultures from this plant were established in shake flasks, in which the production of SC-1 was optimized, reaching values fifty times higher than those registered in field grown plants. Large-scale cultivation of the active biomass from S. chrysotrichum was established in 10 l airlift bioreactors, and productivity levels of SC-1 were increased by 60% when using a draw-fill mode in the bioreactors.
Villarreal
M L
ML
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social Argentina No 1, Xochitepec, Morelos, Mexico.
Nicasio
P
P
Rojas
G
G
Alvarez
L
L
Quintero
R
R
D001709:Biotechnology; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008800:Mexico; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology
D010936:Plant Extracts; D012503:Saponins