Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.
Focused libraries of delta opioid ligands were synthesised using REM resin methodology. Several high affinity compounds were identified with good selectivity over the mu opioid receptor. Automated REM resin recycling was used to synthesise larger amounts of ligand for in vivo studies.
Cottney
J
J
Organon Laboratories Ltd., Newhouse, Scotland, UK.
Rankovic
Z
Z
Morphy
J R
JR
D001549:Benzamides / Q000138:chemical synthesis*; D020128:Inhibitory Concentration 50; D010879:Piperazines / Q000138:chemical synthesis*; D017465:Receptors, Opioid, delta / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry*
D001549:Benzamides; D010879:Piperazines; D017465:Receptors, Opioid, delta; D012116:Resins, Plant; C088464:4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide