title: Management of cancer in pregnancy: a case of Ewing's sarcoma of the pelvis in the third trimester.
abstract: Ewing's sarcoma of the pelvic bones was diagnosed in a 21-year childbearing woman, raising major medical and ethical problems. The diagnostic and therapeutic approaches during the sixth month of gestation were tailored in order to cure the patient and avoid unnecessary toxicity to the fetus. Ancillary tests included ultrasound and MRI studies of the pelvis. Ifosfamide and adriamycin, premedicated by granisetron, were administered during gestation, and were found to be safe. Cesarean section was the preferred way of delivery since the tumor involved the pelvic bones. The outcome was a disease-free patient and a small healthy baby who is now two years of age.
authors.affiliation: Unit of Bone and Soft Tissue Sarcoma, Institut Gustave Roussy, Villejuif, France.
authors.forename: O
authors.initials: O
authors.lastname: Merimsky
authors.forename: T
authors.initials: T
authors.lastname: Le Chevalier
authors.forename: G
authors.initials: G
authors.lastname: Missenard
authors.forename: C
authors.initials: C
authors.lastname: Lepechoux
authors.forename: I
authors.initials: I
authors.lastname: Cojean-Zelek
authors.forename: B
authors.initials: B
authors.lastname: Mesurolle
authors.forename: A
authors.initials: A
authors.lastname: Le Cesne
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D002585:Cesarean Section; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007231:Infant, Newborn; D015918:Infusion Pumps, Implantable; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D015080:Mesna / Q000008:administration & dosage; D010384:Pelvic Bones; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis / Q000379:methods*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000188:drug therapy*; D016216:Ultrasonography, Prenatal
chemical_list: D004317:Doxorubicin; D015080:Mesna; D007069:Ifosfamide