title: [An autopsy case of sudden death caused by untreated sepsis after complete remission of acute promyelocytic leukemia].
abstract: The patient was 63 year-old man. He had been diagnosed as acute promyelocytic leukemia (APL) and treated until 4 month before his death with complete remission. The patient suddenly died 9 days after he complained of occipital headache. Autopsy and histopathologic findings were as follows: the left pleura was thick and calcificated with abscess, compatible with the findings of old tuberculosis complicated with bacterial infection. Furthermore, polynuclear leukocytes and gram-positive micro-organisms were accumulated in the lungs, and pyogenic meningitis, pyonephritis, splenitis were also found. Bacteologically, Streptococcus pneumoniae was detected from cadaver's blood and cerebrospinal fluid. Therefore, we concluded that the patient was died of septic shock caused by systemic infection of Streptococcus pneumoniae. The mortality of septic shock is high and in some patients, causative organisms may not be isolated. In the present case, although the original inflammation was left pleuritis due to Streptococcus pneumoniae, correct clinical diagnosis was not made before death as the patient had lacked any complaints except for occipital headache. This case revealed that the cause of sudden death was sepsis induced by Streptococcus pneumoniae instead of a relapse of APL. This case also illustrated the importance of reviewing the previous history of a patient and doing postmortem bacteologic examination in a case of suspected sepsis.
authors.affiliation: Department of Forensic Medicine, Jikei University, School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hitosugi
authors.forename: K
authors.initials: K
authors.lastname: Fukui
authors.forename: A
authors.initials: A
authors.lastname: Takatsu
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Homori
authors.forename: K
authors.initials: K
authors.lastname: Kawano
mesh_terms: D002423:Cause of Death; D003645:Death, Sudden / Q000473:pathology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000473:pathology*; D012074:Remission Induction; D012772:Shock, Septic / Q000473:pathology*