Confocal reflectance imaging of folliculitis in vivo: correlation with routine histology.
Near-infrared confocal reflectance microscopy (CM) is a high-resolution: non-invasive imaging technique with promising future in dermatology. A pustular lesion from a 35-year-old male with a known history of folliculitis was non-invasively viewed with CM and later biopsied. Optical sections were correlated with routine histology. This optical technique allows us to view non-invasively transverse skin sections to a controlled depth in real time. In the CM images, tissue can be visualize with cellular and subcellular detail as shown by imaging infiltrating neutrophils (PMNs) within the subcorneal pustule of a superficial folliculitis in vivo.
González
S
S
Dermatology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. gonzalsa@helix.mgh.harvard.edu
Rajadhyaksha
M
M
González-Serva
A
A
White
W M
WM
Anderson
R R
RR
D000328:Adult; D005499:Folliculitis / Q000473:pathology*; D018859:Hair Follicle / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D018613:Microscopy, Confocal; D012867:Skin / Q000473:pathology