Schistosoma bovis: vaccine effects of a recombinant homologous glutathione S-transferase in sheep.
The economic importance of the trematode Schistosoma bovis in African livestock has justified the development of a specific vaccine. Administered preventively to sheep, rSb28GST--the only molecule cloned from S. bovis which has demonstrated vaccine potentialities in goats and cattle--reduced the mean worm burden in vaccinated animals and improved their health status compared with that of non-vaccinated controls. As in goats, but not in bovines, the fecundity of the settled worm pairs was not modified. Therefore, rSb28GST can be proposed as a universal tool for the prevention of clinical disorders engendered by the main schistosome species affecting domestic ruminants in the African continent.
Boulanger
D
D
Centre de Recherche sur les Méningites et Schistosomoses (CERMES/OCCGE/ORSTOM), WHO Collaborating Centre for the Control of Schistosomosis, Niamey, Niger. boulange@niamey.orstom.ne
Schneider
D
D
Chippaux
J P
JP
Sellin
B
B
Capron
A
A
D000818:Animals; D005982:Glutathione Transferase / Q000235:genetics / Q000276:immunology*; D010270:Parasite Egg Count; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012547:Schistosoma / Q000201:enzymology* / Q000276:immunology*; D012552:Schistosomiasis / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
D011993:Recombinant Fusion Proteins; D014614:Vaccines, Synthetic; D005982:Glutathione Transferase