title: Effect of azithromycin plus rifampin versus that of azithromycin alone on the eradication of Chlamydia pneumoniae from lung tissue in experimental pneumonitis.
abstract: Azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against Chlamydia pneumoniae AR-39. The combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of C. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis.
authors.affiliation: Department of Clinical Research, Inselspital, University of Bern, Bern, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Wolf
authors.forename: R
authors.initials: R
authors.lastname: Malinverni
mesh_terms: D000818:Animals; D017963:Azithromycin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004269:DNA, Bacterial / Q000032:analysis; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology*; D008297:Male; D051379:Mice; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D004269:DNA, Bacterial; D017963:Azithromycin; D012293:Rifampin