title: Three Hong Kong Chinese cases of pretibial epidermolysis bullosa: a genodermatosis that can masquerade as an acquired inflammatory disease.
abstract: Three patients in two families presented with many years' history of fragile skin, blisters, erosions and scars affecting almost exclusively the shin areas, accompanied by a variable degree of itching. Two of the patients also had toenail dystrophy. Skin biopsy revealed dermal-epidermal blister formation and milia but no immunohistochemical evidence of immunoglobulin or complement deposition. Electron microscopic study of the lesional and perilesional skin showed very sparse or absent anchoring fibrils. Immunolabelling for type VII collagen using LH 7.2 monoclonal antibody revealed a bright, linear staining pattern at the dermal-epidermal junction. The clinicopathological features were thus compatible with pretibial epidermolysis bullosa, a subtype of dystrophic epidermolysis bullosa. Of note, the inflammatory nature of the skin lesions, and their resemblance to nodular prurigo and hypertrophic lichen planus, had caused diagnostic difficulties in all cases in the past. A high degree of awareness of this rare subtype of epidermolysis bullosa is important to establish the correct diagnosis, to allow for genetic counselling and to plan clinical management.
authors.affiliation: Social Hygiene Service, Department of Health, the Government of the Hong Kong Special Administrative Region, Hong Kong.
authors.forename: W Y
authors.initials: WY
authors.lastname: Tang
authors.forename: K C
authors.initials: KC
authors.lastname: Lee
authors.forename: T C
authors.initials: TC
authors.lastname: Chow
authors.forename: K K
authors.initials: KK
authors.lastname: Lo
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001706:Biopsy; D002648:Child; D003094:Collagen / Q000276:immunology; D003872:Dermatitis / Q000175:diagnosis* / Q000235:genetics; D003937:Diagnosis, Differential; D004820:Epidermolysis Bullosa / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009154:Mutation; D009260:Nail Diseases / Q000175:diagnosis / Q000235:genetics
chemical_list: D000911:Antibodies, Monoclonal; D003094:Collagen