title: Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder.
abstract: Given the efficacy of medications that interact with the serotonin transporter (5-HTT) in the treatment of panic disorder, we have used a family-based design to test for genetic association and linkage between panic disorder and a functional polymorphism in the promoter of the gene for 5-HTT. In this study, 340 individuals in 45 families, as well as 74 haplotype relative risk 'trios' were genotyped at the polymorphic locus, which consists of a 44 base pair deletion/insertion. There were no significant differences in allele frequencies or occurrence of genotypes within the triads. No linkage between the 5-HTT polymorphism and panic disorder was observed in the multiplex families, using a variety of simulations for dominant and recessive models of inheritance. Recent reports suggest an association between the 5-HTT polymorphism and anxiety-related traits, as measured with personality assessment. The results reported here provide evidence that the genetic basis of panic disorder may be distinct from anxiety-related traits assessed by personality inventories in normal populations.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Hamilton
authors.forename: G A
authors.initials: GA
authors.lastname: Heiman
authors.forename: F
authors.initials: F
authors.lastname: Haghighi
authors.forename: S
authors.initials: S
authors.lastname: Mick
authors.forename: D F
authors.initials: DF
authors.lastname: Klein
authors.forename: S E
authors.initials: SE
authors.lastname: Hodge
authors.forename: M M
authors.initials: MM
authors.lastname: Weissman
authors.forename: A J
authors.initials: AJ
authors.lastname: Fyer
authors.forename: J A
authors.initials: JA
authors.lastname: Knowles
mesh_terms: D000483:Alleles; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000032:analysis; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D016584:Panic Disorder / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA