title: [A study of hypertriglyceridemia occurring in patients with chronic hepatitis C during administration of interferon beta].
abstract: The prevalence and risk factors of hypertriglyceridemia during the administration of interferon (IFN) were examined in 78 patients with chronic hepatitis C who were treated with 6 MU of IFN-beta once or 3 MU of IFN-beta twice a day for 6 weeks. Hypertriglyceridemia (serum triglyceride (TG) above 150 mg/dl) was found before the start of IFN treatment in 9% of the patients. During the administration of IFN, elevation of serum TG above 150 mg/dl was found in 82% of patients. In addition, serum TG level exceeded 500 mg/dl at least once during the administration of IFN in 13% of patients. On stepwise multiple regression analysis, three risk factors, high serum TG value before the administration of IFN, high ALT value before the administration of IFN, and divided administration of IFN-beta twice daily were found to be associated with hypertriglyceridemia during IFN administration.
authors.affiliation: Department of Gastroenterology, Osaka City General Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Kioka
authors.forename: Y
authors.initials: Y
authors.lastname: Moriyoshi
authors.forename: T
authors.initials: T
authors.lastname: Nakai
authors.forename: K
authors.initials: K
authors.lastname: Sano
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: O
authors.initials: O
authors.lastname: Kurai
authors.forename: H
authors.initials: H
authors.lastname: Nebiki
authors.forename: K
authors.initials: K
authors.lastname: Okawa
authors.forename: H
authors.initials: H
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Harihara
authors.forename: K
authors.initials: K
authors.lastname: So
authors.forename: T
authors.initials: T
authors.lastname: Kuroki
mesh_terms: D000328:Adult; D005260:Female; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D016899:Interferon-beta