title: Paternal monoallelic expression of the paired immunoglobulin-like receptors PIR-A and PIR-B.
abstract: A diverse pattern of polymorphism is defined for the paired Ig-like receptors (PIRs) that serve as activating (PIR-A) and inhibitory (PIR-B) receptors on B lymphocytes, dendritic cells, and myeloid-lineage cells in mice. The monoclonal anti-PIR antibody 10.4 is shown to recognize an allelic PIR-A/PIR-B determinant on cells from BALB/c but not C57BL/6 mice. Other strains of inbred mice also can be typed on the basis of their expression of this PIR allelic determinant. Analysis of (BALB/c x C57BL/6) F1 hybrid offspring indicates that PIR molecules bearing the paternal PIR allotype are expressed whereas PIR-A and PIR-B molecules bearing the maternal allotype are not. The monoallelic expression of the polymorphic PIR-A and PIR-B molecules, and possibly of their human Ig-like transcript/leukocyte Ig-like receptor/monocyte/macrophage Ig-like receptor and killer cell inhibitory receptor relatives, may influence innate and specific immune responses in outbred populations.
authors.affiliation: Division of Developmental and Clinical Immunology, Departments of Medicine, Pediatrics, Microbiology, and Pathology, University of Alabama, Birmingham, AL 35294-3300, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: V
authors.initials: V
authors.lastname: Hurez
authors.forename: J S
authors.initials: JS
authors.lastname: Brockenbrough
authors.forename: H
authors.initials: H
authors.lastname: Kubagawa
authors.forename: M D
authors.initials: MD
authors.lastname: Cooper
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D011971:Receptors, Immunologic / Q000235:genetics* / Q000276:immunology
chemical_list: D008562:Membrane Glycoproteins; C105948:Pira1 protein, mouse; C105949:Pirb protein, mouse; D011971:Receptors, Immunologic