title: Patterns of relative cerebral blood flow in minor cognitive motor disorder in human immunodeficiency virus infection.
abstract: Individuals infected with HIV are at risk to develop cognitive impairment during the course of their disease. Although many patients develop an HIV-associated dementia, others may develop the less severe minor cognitive motor disorder (MCMD). In this study, relative cerebral blood flow was measured with PET imaging in HIV+ MCMD patients, HIV+ control subjects, and HIV- control subjects; analyses were performed by using statistical parametric mapping. Comparing a short-term memory task versus a rest state yielded activation in superior temporal cortex, postcentral gyrus, and cerebellum in all three subject groups. Comparing long- and short-term memory tasks yielded activation throughout the frontal cortex, including BA46. Activation in this area was reduced in the HIV+ control subjects and further reduced in the MCMD+ patients. Thus, brain activation associated with lower-level, automatic processing appears normal in HIV+ MCMD+ subjects, but activation associated with effortful retrieval and organizational processes is abnormal.
authors.affiliation: Neuropsychology Research Program, University of Pittsburgh Medical Center, Pennsylvania, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Wiseman
authors.forename: J A
authors.initials: JA
authors.lastname: Sanchez
authors.forename: C
authors.initials: C
authors.lastname: Buechel
authors.forename: M A
authors.initials: MA
authors.lastname: Mintun
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: D
authors.initials: D
authors.lastname: Milko
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015658:HIV Infections / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D013647:Task Performance and Analysis; D014055:Tomography, Emission-Computed