Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland.
A dedifferentiated acinic cell carcinoma (AciCC) of the right parotid gland with lymph node metastases occurred in a 36-year-old woman. The tumour was associated with a bilateral well-differentiated AciCC. The two components of this tumour had different (high and low) proliferative activity measured by Mib-1 and different (aneuploid and diploid) DNA content. Despite the presence of a high-grade component, TP53 mutations, microsatellite instability (MSI) and/or loss of heterozygosity (LOH) at the p53 locus were not detected. Although the follow-up of the patient is very short, the aggressiveness of the tumour is shown by a recurrence in the right parotid within 4 months and by the rapid development of regional metastases.
Di Palma
S
S
Division of Pathology and Cytopathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy. dipalma@istitutotumori.mi.it
Corletto
V
V
Lavarino
C
C
Birindelli
S
S
Pilotti
S
S
D000328:Adult; D000782:Aneuploidy; D034961:Antigens, Nuclear; D018267:Carcinoma, Acinar Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002454:Cell Differentiation; D002455:Cell Division; D004273:DNA, Neoplasm / Q000032:analysis; D004171:Diploidy; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D019656:Loss of Heterozygosity; D008207:Lymphatic Metastasis; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins / Q000032:analysis; D010307:Parotid Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction
D034961:Antigens, Nuclear; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D009687:Nuclear Proteins