title: Nasal nocardiosis in a calf.
abstract: Nasal nocardiosis was found in a female Japanese Black calf, 11 months of age. Macroscopically, the posterior half of the left nasal passage was completely obstructed by yellowish brown caseous substance and the mucosa was irregularly thickened. In the brain, a few soft brown foci were present in the olfactory bulb and frontal lobe. Microscopically, there were closely packed granulomas in the nasal cavity and brain. The lesions were characterized by a center of cellular debris surrounded by epithelioid macrophages, neutrophils, lymphocytes and multinucleated giant cells of the Langhans type. Special stains revealed the presence of a large number of filamentous branching gram-positive, partially acid-fast organisms in these epithelioid cells and giant cells, and in cellular debris.
authors.affiliation: Department of Veterinary Pathology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Toda
authors.forename: N
authors.initials: N
authors.lastname: Kakiichi
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Sako
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: N
authors.initials: N
authors.lastname: Takemura
authors.forename: S
authors.initials: S
authors.lastname: Kamata
authors.forename: M
authors.initials: M
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006099:Granuloma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D009297:Nasal Mucosa / Q000473:pathology; D009617:Nocardia Infections / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012220:Rhinitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*