Activation and disturbance of blood haemostasis following strenuous physical exercise.
Physical exercise activates blood coagulation and enhances fibrinolytic activity. To investigate whether these activations of blood coagulation and fibrinolysis are balanced post-exercise and during the period of recovery, 11 moderately active young men were examined immediately after a standardised cycle ergometer test and during the 24 h period of recovery. Blood samples were obtained at rest, immediately after exercise, and 2, 6 and 24 h after exercise. All post-exercise values were corrected for any change in plasma volume. Exercise induced a significant increase in factor VIII activity and this occurred with a significant shortening of activated partial thromboplastin time. A concomitant enhancement of tissue plasminogen activity resulted in significant increases in tissue plasminogen activity antigen and total fibrin/fibrinogen degradation products, and a significant decrease in tissue plasminogen activator inhibitor-1 activity. Increases in coagulation and fibrinolytic activity changed in parallel during exercise. However, during recovery, while the increase in factor VIII activity post-exercise persisted 2 and 6 h into recovery, fibrinolytic activity demonstrated a sharp fall. It is concluded that whereas the enhanced fibrinolytic activity during exercise appears to counterbalance the increase in blood coagulability, this haemostatic balance is not maintained during recovery. This perturbed blood haemostasis could constitute an enhanced risk for coronary artery thrombosis and may contribute to exercise-related cardiovascular events.
Lin
X
X
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, UK. nnxxl@nnnl.nottingham.ac.uk
El-Sayed
M S
MS
Waterhouse
J
J
Reilly
T
T
D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D015944:Factor VIIIa / Q000032:analysis / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D010953:Plasma Volume; D014914:Whole Blood Coagulation Time
D015944:Factor VIIIa