Effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum.
The effect of HSR-903, a new fluoroquinolone, on the concentration of theophylline in serum in healthy male volunteers was investigated. The concentration of theophylline in serum and the urinary excretion rates of theophylline on day 5 of concomitant dosing with HSR-903 tended to increase compared to those on day 4, when theophylline was given alone; however, the urinary excretion rates of 1-methyluric acid and 3-methylxanthine on day 5 of concomitant dosing with HSR-903 tended to decrease in comparison to those on day 4, when theophylline was given alone.
Niki
Y
Y
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan. resp@med.kawasaki-m.ac.jp
Watanabe
S
S
Tamada
S
S
Yoshida
K
K
Miyashita
N
N
Nakajima
M
M
Matsushima
T
T
Sekino
H
H
Matsuoka
O
O
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D013806:Theophylline; C106426:olamufloxacin