The use of fMRI for determining the topographic organization of cortical fields in human and nonhuman primates.
In this study, we demonstrate activation of somatosensory cortex in the anesthetized macaque monkey and awake human using fMRI, and confirm the topographic organization of somatosensory cortex previously described in both species. The macaque model provides an efficient means of addressing questions regarding the capabilities and neurophysiological relevance of fMRI, and serves as an interface between established invasive electrophysiological methods in nonhuman primates, and noninvasive imaging assays of functional activation in humans.
Disbrow
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Biomagnetic Imaging Laboratory, Box 0628, Department of Radiology, University of California, 513 Parnassus Ave., San Francisco, CA 94143, USA. elizabeth.disbrow@radiology.ucsf.edu
Roberts
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TP
Slutsky
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D
Krubitzer
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L
D000777:Anesthetics; D000818:Animals; D001931:Brain Mapping; D005240:Feasibility Studies; D006801:Humans; D008253:Macaca mulatta; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*
D000777:Anesthetics