[Influence of food on the bioavailability of isoniazid in health volunteers].
From the theoretical point of view, food intake exerts a complex influence on the bioavailability of drugs. It may interfere with tablet disintegration, drug dissolution and drug transit through the gastrointestinal tract, may also affect the metabolic transformation of drugs in the gastrointestinal wall and the liver. The knowledge about the influence of food is very important in treatment of tuberculosis, where the drugs are taken once daily or even less frequently. We studied the isoniazid concentrations in blood serum of 20 volunteers (12 slow and 8 fast acetylators of INH) both sexes, after the drug intake 2 hours before breakfast and immediately after breakfast. Concentrations of INH were tested by biological method with Mycobacterium aurum REB as a standard strain. The results have shown, that Cmax (3.55 +/- 0.29 versus 2.56 +/- 0.49 in fast acetylators and 4.34 +/- 0.2 versus 3.67 +/- 0.37 in slow acetylators), tmax (0.75 +/- 0.26 versus 1.31 +/- 0.37 in fast acetylators and 0.87 +/- 0.31 versus 1.79 +/- 0.62 in slow acetylators and AUC0-t (6.6 +/- 1.34 versus 5.47 +/- 1.5 in fast acetylators and 21.82 +/- 2.57 versus 18.61 +/- 2.57 in slow acetylators) are significantly decreased after ingestion of INH with breakfast.
Zwolska
Z
Z
Zakładu Mikrobiologii, Instytutu Gruźlicy i Chorób Płuc w Warszawie.
Niemirowska-Mikulska
H
H
Augustynowicz-Kopeć
E
E
D000107:Acetylation; D000328:Adult; D000995:Antitubercular Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D004435:Eating; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000493:pharmacokinetics*; D008297:Male; D009161:Mycobacterium / Q000187:drug effects; D012016:Reference Values
D000995:Antitubercular Agents; D007538:Isoniazid