[CA 125 in the department of internal medicine--a marker of ovarian tumor, thoracic fluid or ascites?].
The authors describe three cases of falsely elevated values of the tumour marker CA 125 which in medical practice is considered above all a sign of ovarian tumours. In one case CA 125 was elevated in fibrinopurulent pleuropneumonia and refractory ascites and in one instance haemorrhagic fluidothorax was involved associated with pleuritis and in one instance an abscess of the subhepatic region. From data in the literature ensues that this increase can be associated with activation of mesothelioma cells (either in the pleura or peritoneum) in non-malignant diseases. Therefore in patients with elevated CA 125 and fluidothorax or ascites, unless ovarian carcinoma is proved, this fact should be taken into account in diagnostic considerations.
Kasalický
P
P
I. interní klinika IPVZ-FTN, Praha.
Kocián
J
J
D000368:Aged; D001201:Ascites / Q000175:diagnosis*; D014408:Biomarkers, Tumor / Q000032:analysis; D018394:CA-125 Antigen / Q000032:analysis*; D005189:False Positive Reactions; D005260:Female; D006491:Hemothorax / Q000175:diagnosis*; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D010996:Pleural Effusion / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen