title: [Impaired signal transduction in T-lymphocytes of the aged].
abstract: An age-related dysfunction of the immune system, and especially of the T lymphocytes, is the most common feature observed during aging. It is well recognized by now that changes in the molecular mechanisms connecting the antigen receptor of the T cell with its nuclear machinery, commonly called 'signal transduction pathways' are the basis for this dysfunction. This paper is an up-to-date review of current literature of the problem, describing age-related changes in the functioning of three major, complementary pathways of signal transduction in murine and human T cell: IP3/Ca2+/calcineurin, DAG/protein kinase C (PKC) and Ras/MAP kinases, discovered so far.
authors.affiliation: Katedra i Zakład Fizjopatologii, Akademii Medycznej w Gdańsku.
authors.forename: J M
authors.initials: JM
authors.lastname: Witkowski
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D051379:Mice; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D011494:Protein Kinases; D002118:Calcium