title: [Infectious endocarditis: immune disorders, differentiated therapy].
abstract: OBJECTIVE
  Immunological assessment of variants of infectious endocarditis (IE) and design of differentiated approach to the disease therapy.
  
  
  METHODS
  Of 150 patients treated (90 males and 60 females, mean age 41.9 +/- 3.3 years) 28.7% and 71.3% had primary and secondary endocarditis, respectively. With chronization of the process, there was a trend to growing immune unbalance (IU).
  
  
  RESULTS
  The IU in IE patients manifested with leukocytosis changing for leukopenia, reduced absolute and relative number of lymphocytes, complement, T- and B-lymphocytes, growing content of CIC, IgM, rheumatoid factor and cryoproteins.
  
  
  CONCLUSIONS
  Besides antibacterial therapy, IE patients need immunocorrective and efferent therapy.
authors.forename: I P
authors.initials: IP
authors.lastname: Tatarchenko
authors.forename: V T
authors.initials: VT
authors.lastname: Komarov
authors.forename: R P
authors.initials: RP
authors.lastname: Savchenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D003450:Cryoglobulins / Q000378:metabolism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D010956:Plasmapheresis; D013601:T-Lymphocytes / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D007075:Immunoglobulin M