Effects of Fructus schizandrae on cycloheximide-induced amnesia in rats.
The effects of Fructus Schisandrae (Schizandra Chinensis, (FS) on cycloheximide (CXM)-induced amnesia by using a passive avoidance task were studied in rats. FS at 0.25 and 0.75 g/kg administered for 1 week significantly prolonged the CXM-shortened step-through latency (STL). Of the fractions (n-hexane, chloroform and water), only the water fraction at 25 mg/kg administered for 1 week prolonged the CXM-shortened STL. These results suggest that the water fraction is the main active fraction of FS.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, R.O.C.
Tsai
M L
ML
Peng
W H
WH
Wu
C R
CR
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning; D003513:Cycloheximide / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D003513:Cycloheximide