[A study of hypertriglyceridemia occurring in patients with chronic hepatitis C during administration of interferon beta].
The prevalence and risk factors of hypertriglyceridemia during the administration of interferon (IFN) were examined in 78 patients with chronic hepatitis C who were treated with 6 MU of IFN-beta once or 3 MU of IFN-beta twice a day for 6 weeks. Hypertriglyceridemia (serum triglyceride (TG) above 150 mg/dl) was found before the start of IFN treatment in 9% of the patients. During the administration of IFN, elevation of serum TG above 150 mg/dl was found in 82% of patients. In addition, serum TG level exceeded 500 mg/dl at least once during the administration of IFN in 13% of patients. On stepwise multiple regression analysis, three risk factors, high serum TG value before the administration of IFN, high ALT value before the administration of IFN, and divided administration of IFN-beta twice daily were found to be associated with hypertriglyceridemia during IFN administration.
Kioka
K
K
Department of Gastroenterology, Osaka City General Hospital.
Moriyoshi
Y
Y
Nakai
T
T
Sano
K
K
Aoki
T
T
Kurai
O
O
Nebiki
H
H
Okawa
K
K
Oka
H
H
Harihara
S
S
So
K
K
Kuroki
T
T
D000328:Adult; D005260:Female; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology*; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D016899:Interferon-beta