title: [The joint use of prednisolone and phospholipid-containing hepatoprotectors in experimental chronic hepatitis].
abstract: In chronic CCl4-hepatitis in rats phospholipid-containing hepatoprotectors, essentiale and eplir differ in their influence on the therapeutic effect of prednisolone; essentiale does not change the antiproliferative effect of the glucocorticoid and weakens its membrane-stabilizing effect, eplir increases these therapeutic effects of prednisolone. Besides, eplir, in distinction from essentiale, reduces lipid accumulation in the liver and hypoproteinemia which are induced by prednisolone.
authors.affiliation: Department of Pharmacology, Siberian Medical University, Tomsk, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovskiĭ
authors.forename: E L
authors.initials: EL
authors.lastname: Golovina
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Kovalenko
authors.forename: V S
authors.initials: VS
authors.lastname: Chuchalin
authors.forename: E V
authors.initials: EV
authors.lastname: Saprykina
authors.forename: N V
authors.initials: NV
authors.lastname: Sosnina
authors.forename: V N
authors.initials: VN
authors.lastname: Burkova
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D002338:Carotenoids / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use*; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010743:Phospholipids / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D051381:Rats
chemical_list: D004338:Drug Combinations; D005938:Glucocorticoids; D010713:Phosphatidylcholines; D010743:Phospholipids; C064845:eplir; C011246:essential 303 forte; D002338:Carotenoids; D011239:Prednisolone