Regulation and characterization of the Na+/H+ exchanger.
The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.
Fliegel
L
L
Department of Biochemistry, University of Alberta, Edmonton, Canada. lfliegel@gpu.srv.ualberta.ca
Murtazina
R
R
Dibrov
P
P
Harris
C
C
Moor
A
A
Fernandez-Rachubinski
F A
FA
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D011817:Rabbits; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000737:chemistry* / Q000502:physiology*
D017923:Sodium-Hydrogen Exchangers