Effects of eyelid scrubbing on the lid margin.
OBJECTIVE
To compare the effects of eyelid scrubbing with an eyelid cleansing solution (ECS) to eyelid scrubbing with ECS and the addition of antibacterial or anti-inflammatory pharmaceuticals on the clinical appearance, microbial status, tissue histology, and the inflammatory cell profile of the normal eyelid margin.


METHODS
Eyelid scrubbing was performed twice daily using ECS; ECS with the antibacterial sulfacetamide (ECS+); and ECS with sulfacetamide and prednisolone acetate (ECS++) over a 21 day period on three groups of 16 rabbits with clinically normal eyelids.


RESULTS
Significant hyperemia of the margin occurred in all three groups over the 3 week period; however, the degree of hyperemia was less with ECS+ (P<0.05) and ECS++ (P<0.05). Chemosis, tearing, mucus discharge, and the microbial status were not significantly different than controls. There were no marked histologic differences in the tissues, except for increased red blood cell packing in the small vessels near the lid margins in scrubbed eyelids, consistent with hyperemia. The inflammatory cell profile showed minimal changes that were not statistically significant in any of the three groups, except that >50% of mast cells showed evidence of degranulation.


CONCLUSIONS
Use of ECS with an antibiotic, or an antibiotic and steroid solution, resulted in less inflammation than scrubbing with ECS alone.
Greiner
J V
JV
Schepens Eye Research Institute, Boston, MA 02114, USA.
Leahy
C D
CD
Glonek
T
T
Hearn
S L
SL
Auerbach
D
D
Davies
L
L
D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001762:Blepharitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D002452:Cell Count; D003261:Contact Lenses / Q000009:adverse effects; D004338:Drug Combinations; D005143:Eyelids / Q000187:drug effects / Q000473:pathology*; D005500:Follow-Up Studies; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011817:Rabbits; D013409:Sulfacetamide / Q000008:administration & dosage*; D013501:Surface-Active Agents / Q000008:administration & dosage*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D013501:Surface-Active Agents; D013409:Sulfacetamide; C009935:prednisolone acetate; D011239:Prednisolone