The biology of P-selectin glycoprotein ligand-1: its role as a selectin counterreceptor in leukocyte-endothelial and leukocyte-platelet interaction.
Cell-cell interactions mediating leukocyte trafficking, thrombogenesis and inflammation are crucial for the host defense mechanism. The selectin family of integral membrane proteins includes E-selectin, L-selectin and P-selectin. Selectins mediate tethering and rolling of leukocytes to the vessel wall at the site of inflammation. The counter-receptor for P-selectin and possibly the other selectins is P-selectin glycoprotein ligand-1 (PSGL-1). This review focuses on the properties and biology of PSGL- 1.
Yang
J
J
Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Furie
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BC
Furie
B
B
D000818:Animals; D001792:Blood Platelets / Q000166:cytology* / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D019007:P-Selectin / Q000502:physiology*
D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein