In vivo cytokine and neuroendocrine responses to endotoxin in human immunodeficiency virus-infected subjects.
The cytokine and neuroendocrine host responses to experimental challenge with lipopolysaccharide (LPS) were studied in human immunodeficiency virus (HIV)-infected subjects and uninfected control subjects. Elevations in circulating concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 were significantly greater in HIV-infected subjects than control subjects after LPS challenge. All subjects showed a significant increase in circulating concentrations of adrenocorticotropin, cortisol, and norepinephrine after LPS challenge, but there was not a significant difference between the responses of these hormones in the HIV-infected and -uninfected subjects. Compared with the control subjects, the HIV-infected subjects had a significantly reduced IL-10 response and a reduced IL-1 receptor antagonist response. It is concluded that the TNF-alpha, IL-6, IL-8, and IL-10 cytokine responses to LPS in vivo are disrupted in HIV subjects but that this is not related to disruption of the hypothalamo-pituitary-adrenal axis.
da Silva
B
B
Endocrine Divison, Northwestern University Medical School, Chicago, IL 60611, USA. b-dasilva@nwu.edu
Singer
W
W
Fong
I W
IW
Ottaway
C A
CA
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007378:Interleukins / Q000032:analysis; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D008954:Models, Biological; D009490:Neurosecretory Systems / Q000187:drug effects*; D009638:Norepinephrine / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D007378:Interleukins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D009638:Norepinephrine