Urodynamic features of the gastric pouch after radical cystectomy and the relationship to oral intake.
OBJECTIVE
We studied the motility of orthotopic bladder substitution with stomach (gastric pouch) in adults with bladder cancer and the effect of oral intake as measured on urodynamics. We also investigated the probable relationship between continence and sensitivity of the proximal urethra. Anticholinergic medication effects on pouch motility were tested.


METHODS
Six patients with a gastric pouch were questioned about quality of life 6 to 43 months after surgery, and examined urodynamically before and after oral intake. During the examination the proximal urethra (directly under the anastomosis between the pouch and urethra) was electrically stimulated to determine sensitivity. We tried to inhibit the peristaltic contractions with 20 mg. butylscopolamine intravenously.


RESULTS
The main difference before and after oral intake was the onset time of peristaltic contractions. After eating the contractions began at a lower filling volume, which was statistically significant. There were no or insignificant differences in capacity and urodynamic parameters. We were successful in inhibiting the peristaltic contractions with anticholinergic medication.


CONCLUSIONS
The gastric pouch is a valuable bladder substitute with sufficient volume, antireflux characteristics, satisfactory continence rate and adequate voiding behavior. Oral intake causes motor activity of the gastric pouch at a lower fill volume than fasting during urodynamic investigation. Anticholinergic medication may be useful for inhibiting peristalsis in the gastric pouch.
Acar
O
O
Urological Clinic, Zurich, Switzerland.
John
H
H
Hauri
D
D
D000284:Administration, Oral; D000368:Aged; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage*; D015653:Cystectomy; D004558:Electric Stimulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D013270:Stomach / Q000637:transplantation; D016476:Urinary Reservoirs, Continent / Q000502:physiology*; D014563:Urodynamics / Q000187:drug effects* / Q000502:physiology*
D018727:Muscarinic Antagonists; D002086:Butylscopolammonium Bromide