title: Structure and evolution of the extended B7 family.
abstract: Here, Joëlle Henry and colleagues explore structural and evolutionary relationships between the B7 costimulator molecules and a growing number of molecules encoded within the major histocompatibility complex. They propose that B7 and MHC genes are derived from a common ancestor, with several members of this large gene family possibly having pivotal influences on T-cell activation.
authors.affiliation: CNRS ER1794, Faculté de Médecine 87025 Limoges, France.
authors.forename: J
authors.initials: J
authors.lastname: Henry
authors.forename: M M
authors.initials: MM
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Pontarotti
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018122:B7-1 Antigen / Q000145:classification* / Q000235:genetics* / Q000502:physiology; D005075:Biological Evolution; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000145:classification; D008285:Major Histocompatibility Complex / Q000235:genetics; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment
chemical_list: D018122:B7-1 Antigen; D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region