[Fibrinolytic substances formation by cancer. Pathogenetic sequelae].
A survey of literature has been presented relating to fibrinolytic substances secreted by malignant tumors, and the role of those substances in the progression of cancer. Particular attention has been given to the effects of plasmin proteolysis which is generated in the extracellular matrix by urokinase plasminogen activator (uPA) complexed with its receptor (uPAR). The paper also discusses the usefulness of the markings of the substances under discussion for diagnostic-prognostic purposes, and a perspective of using the new research in therapy, for example, by using antibodies anti-uPA and anti-uPAR.
Uszyński
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Katedry i Zakładu Propedeutyki Medycyny Akademii Medycznej w Bydgoszczy.
D014408:Biomarkers, Tumor / Q000378:metabolism*; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D014408:Biomarkers, Tumor; D010447:Peptide Hydrolases; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator