[Experimental study of residual virulence of viral vaccine strains].
Residual virulence of three vaccinia strains: Neurovaccine, L-IVP, and its recombinant Revacs-B expressing HBs and preS2 antigens of hepatitis B virus is compared. Insertion of HBs and preS2 antigens of hepatitis B virus in the genome of vaccinia virus strain L-IVP decreases its residual virulence and leads to a benign course of vaccinal reaction involving no deaths of rabbits, cotton rats, or guinea pigs. We may expect that recombinant vaccine Revacs B based on L-IVP strain will cause no postvaccinal complications under conditions of an appreciable decrease in population immunity to vaccinia virus.
Makhlaĭ
A A
AA
Bektimirov
T A
TA
Borisevich
S V
SV
Mikhaĭlov
V V
VV
Perekrest
V V
VV
Podkuĭko
V N
VN
Kirillov
V B
VB
Levitov
A T
AT
Ruchko
V M
VM
D000818:Animals; D006168:Guinea Pigs; D006514:Hepatitis B Surface Antigens / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics; D011817:Rabbits; D016205:Sigmodontinae; D014616:Vaccinia virus / Q000276:immunology* / Q000472:pathogenicity; D014759:Viral Envelope Proteins / Q000235:genetics; D014765:Viral Vaccines / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism; D014774:Virulence
D006514:Hepatitis B Surface Antigens; D011498:Protein Precursors; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C050807:presurface protein 2, hepatitis B surface antigen