[Effects of L-carnitine on erythropoiesis and blood platelet aggregation in patients with chronic renal failure treated with hemodialysis].
The aim of the work has to assess the effects of L-carnitine therapy on erythropoiesis and whole blood platelet aggregation. The studies were performed in 28 patients divided into 3 groups: I-group was given erythropoietin, II-group was given erythropoietin and L-carnitine, III-group was given L-carnitine. After 22 month of the therapy a statistically significant rise in hematocrit was observed in group III, improvement in muscle strength, a rise in free and total carnitine concentration was found in group II and III. There were no significant changes in urea concentration, platelet count and iron metabolism. Whole blood platelet aggregation induced by ADP, collagen and ristocetin was impaired relative to healthy volunteers. After 2 month of L-carnitine treatment of significant rise in collagen induced platelet aggregation was observed in group II.
Kalinowski
M
M
Kliniki Nefrologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku.
Popławski
A
A
Mazerska
M
M
Daniluk
A
A
D000328:Adult; D002331:Carnitine / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D006435:Renal Dialysis / Q000379:methods; D051437:Renal Insufficiency / Q000628:therapy*
D004921:Erythropoietin; D002331:Carnitine