Efficacy of shitei-to, a traditional Chinese medicine formulation, against convulsions in mice.
The anticonvulsant effects of Shitei-To and its components on maximal electroshock seizures and chemical convulsions were examined. Shitei-To significantly prolonged the latency to bicuculline (2.0 mg/kg, s.c.)-induced clonic convulsions. Repeated treatment with Shitei-To also significantly prolonged the latency to strychnine (1.5 mg/kg, i.p.)- and pentylenetetrazol (90 mg/kg, i.p.)-induced clonic convulsions. On the other hand, Shitei-To had no effect on maximal electroshock seizures. Of the components of Shitei-To, Shitei had almost the same effect as Shitei-To against the clonic convulsions induced by the three chemical agents tested. These findings suggest that Shitei-To has anticonvulsant effects.
Minami
E
E
Central Research Laboratory, Kotaro Pharmaceutical Co. Ltd., Osaka, Japan.
Shibata
H
H
Nunoura
Y
Y
Nomoto
M
M
Fukuda
T
T
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001640:Bicuculline; D003292:Convulsants; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004597:Electroshock; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013331:Strychnine
D000927:Anticonvulsants; D003292:Convulsants; D004365:Drugs, Chinese Herbal; C120103:shitei-to; D013331:Strychnine; D010433:Pentylenetetrazole; D001640:Bicuculline