[Effect of octreotide on the clinical course of acute pancreatitis and levels of free oxygen radicals and antioxidants].
Twenty-one patients with a medium severe form of acute pancreatitis were divided into two groups. Eleven were treated with octreotide, 200 micrograms s.c. every 8 hours, combined with standard conservative treatment, 10 patients had the same treatment but without octreotide. In the octreotide-treated group the level of free oxygen radicals and important antioxidants--vitamins A, E and C--was assessed. In the octreotide-treated group the authors found after five days normal levels of originally elevated free oxygen radicals and a significant increase of the vitamin C level. As compared with the control group, in the octreotide group the period of hospitalization was significantly shorter (9.8 +/- 3.2 vs. 13.7 +/- 4.7). The number of complications was not affected.
Lata
J
J
III. interní-gastroenterologická klinika FN, Brno-Bohunice.
Dítĕ
P
P
Julínková
K
K
Precechtĕlová
M
M
Prásek
J
J
D000208:Acute Disease; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000097:blood*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy*
D000975:Antioxidants; D005609:Free Radicals; D005765:Gastrointestinal Agents; D015282:Octreotide