title: Dilated cardiomyopathy of Doberman pinschers: retrospective histomorphologic evaluation of heart from 32 cases.
abstract: Dilated cardiomyopathy of Doberman Pinschers (DCDP) is a progressive disease often presenting with a history of episodic weakness and syncope, or with clinical signs of predominantly left-sided congestive heart failure. A systematic dissection and histomorphologic evaluation of the heart from 32 Doberman Pinschers with a clinical diagnosis of dilated cardiomyopathy revealed a highly specific location for the characteristic myocardial lesions. The lesions of DCDP were found only in the left ventricular free wall, and in 30 cases, the lesions were characterized by myofiber degeneration and atrophy, and replacement of myocardium by dense bundles of collagen and clusters of adipocytes. In the two remaining hearts, myofiber atrophy and degeneration were accompanied by collagen deposition, but not adipocytes. In stained longitudinal (base to apex) tissue sections of the left ventricle, the lesions of DCDP were usually apparent to the unaided eye; appearing as a central linear pale zone, aligned in the long axis of the ventricular free wall. The lesions did not contain inflammatory cell infiltrates and often involved > 50% of ventricular wall.
authors.affiliation: Toxicology Department, Sanofi Pharmaceuticals Inc., Malvern, PA, USA. rayeve@aol.com
authors.forename: R M
authors.initials: RM
authors.lastname: Everett
authors.forename: J
authors.initials: J
authors.lastname: McGann
authors.forename: H C
authors.initials: HC
authors.lastname: Wimberly
authors.forename: J
authors.initials: J
authors.lastname: Althoff
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D008297:Male; D009206:Myocardium / Q000473:pathology*; D012189:Retrospective Studies