[The effect of orthofen (diclofenac) on the embryogenesis of laboratory mice].
The effect of ortophen on the embryogenesis of laboratory mice of two inbred lines BALB/c and C57B1/6 and of outbred stock NMR was studied. The drug was injected intraperitoneally on days 1-6, 6-16, and 16-18 of pregnancy in a therapeutic dose (1 mg/g) and 10-fold doses. General development of the fetuses was delayed and the condition of the pregnant females of both lines and the stock deteriorated on injection of the drug in a 10-fold dose on days 16-18 of pregnancy. BALB/c mice proved to be most sensitive to the unfavorable effects of sodium diclophenac.
Bogdanenko
E V
EV
Laboratory of Thermodynamics and Energetics of Biological Systems, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Sviridov
Iu V
IuV
Sadovnikov
V B
VB
Zhdanov
R I
RI
D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000209:etiology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D047108:Embryonic Development / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011247:Pregnancy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac