[Infectious endocarditis: immune disorders, differentiated therapy].
OBJECTIVE
Immunological assessment of variants of infectious endocarditis (IE) and design of differentiated approach to the disease therapy.


METHODS
Of 150 patients treated (90 males and 60 females, mean age 41.9 +/- 3.3 years) 28.7% and 71.3% had primary and secondary endocarditis, respectively. With chronization of the process, there was a trend to growing immune unbalance (IU).


RESULTS
The IU in IE patients manifested with leukocytosis changing for leukopenia, reduced absolute and relative number of lymphocytes, complement, T- and B-lymphocytes, growing content of CIC, IgM, rheumatoid factor and cryoproteins.


CONCLUSIONS
Besides antibacterial therapy, IE patients need immunocorrective and efferent therapy.
Tatarchenko
I P
IP
Komarov
V T
VT
Savchenko
R P
RP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D003450:Cryoglobulins / Q000378:metabolism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D010956:Plasmapheresis; D013601:T-Lymphocytes / Q000276:immunology*; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D007075:Immunoglobulin M