title: A new bistetrahydrofuran acetogenin from the roots of Annona salzmanii.
abstract: A new bistetrahydrofuran acetogenin, salzmanin (1), was isolated from the MeOH extract of Annona salzmanii, in addition to the known compounds, squamocin, almunequin, bullatalicin, and annonacin. The structure of 1 was elucidated by spectroscopic methods, including LSIMS-MS technique, and confirmed by a chemical transformation. The cytotoxic activity of 1 and squamocin was investigated.
authors.affiliation: Laboratoire de Pharmacognosie, U.R.A. 1843 CNRS (BIOCIS), Faculté de Pharmacie, 92296 Châtenay-Malabry, France.
authors.forename: E F
authors.initials: EF
authors.lastname: Queiroz
authors.forename: F
authors.initials: F
authors.lastname: Roblot
authors.forename: A
authors.initials: A
authors.lastname: Cavé
authors.forename: R
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: L
authors.initials: L
authors.lastname: Serani
authors.forename: O
authors.initials: O
authors.lastname: Laprévote
authors.forename: M Q
authors.initials: MQ
authors.lastname: Paulo
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C120207:salzmanin; C059660:squamocin; D015107:4-Butyrolactone