title: Wada difference a day makes: interpretive cautions regarding same-day injections.
abstract: OBJECTIVE
  To determine whether memory scores after second intracarotid amobarbital procedure (IAP) injections are affected by the time between the first and second injections.
  
  
  METHODS
  Sixty-two patients received their second IAP injection on the day after the first injection. Forty-three other patients received the second injection on the same day as the first injection. Both groups underwent similar IAP protocols and memory assessments, except for the timing of the second injection.
  
  
  RESULTS
  The second IAP memory scores in the two-day group were significantly higher (p < 0.05) than those in the one-day group. Timing of second injection was a significant correlate of second memory scores, but amobarbital dosage, first IAP memory score, and pre-IAP measures of memory and intelligence were not significant correlates.
  
  
  CONCLUSIONS
  One-day and two-day IAP protocols do not result in similar memory scores after the second injection. Nineteen percent of a subset of patients in the one-day protocol were misclassified, in terms of IAP memory ratings, because of the deleterious effect of having both injections on the same day. It is recommended that correction scores be considered, for some patients who receive two IAP injections on one day, to approximate what the second IAP memory score would have been had the second injection occurred on a second day.
authors.affiliation: Department of Psychology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Grote
authors.forename: C
authors.initials: C
authors.lastname: Wierenga
authors.forename: M C
authors.initials: MC
authors.lastname: Smith
authors.forename: A M
authors.initials: AM
authors.lastname: Kanner
authors.forename: D C
authors.initials: DC
authors.lastname: Bergen
authors.forename: G
authors.initials: G
authors.lastname: Geremia
authors.forename: W
authors.initials: W
authors.lastname: Greenlee
mesh_terms: D000293:Adolescent; D000328:Adult; D000654:Amobarbital; D018686:Anesthetics, Intravenous; D004827:Epilepsy / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009483:Neuropsychological Tests; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D000654:Amobarbital