title: Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
abstract: Lactonamycin (1) was isolated from a culture broth of Streptomyces rishiriensis MJ773-88K4. Antibiotic 1 exhibited antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: N
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Homma
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Sawa
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: N
authors.initials: N
authors.lastname: Heida
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D000970:Antineoplastic Agents / Q000494:pharmacology; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D016106:Methicillin Resistance; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D007211:Indoles; D009285:Naphthoquinones; C102442:lactonamycin; D014640:Vancomycin