Gilvusmycin, a new antitumor antibiotic related to CC-1065.
A new antitumor antibiotic gilvusmycin was isolated from the culture broth of Streptomyces sp. QM16. The structure of gilvusmycin was related to CC-1065 and determined by NMR spectral analysis. Gilvusmycin exhibited antitumor activity against murine leukemia P388 in vivo.
Tokoro
Y
Y
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Isoe
T
T
Shindo
K
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D003470:Culture Media; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000145:classification / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D007211:Indoles; D009285:Naphthoquinones; C102442:lactonamycin