title: Metallopeptide approach to the design of biologically active ligands: design of specific human neutrophil elastase inhibitors.
abstract: A series of compounds was designed to inhibit human neutrophil elastase utilizing a modified metallopeptide scheme developed in our laboratory termed metal-ion induced distinctive array of structures (MIDAS). These metallopeptides, synthesized by solution and solid-phase methods, exhibited excellent structural diversity and specificity in inhibiting human neutrophil elastase.
authors.affiliation: Palatin Technologies Inc., Edison Corporate Center, NJ 08837, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Shi
authors.forename: S
authors.initials: S
authors.lastname: Sharma
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D008667:Metalloproteins / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D008667:Metalloproteins; D010455:Peptides; D019272:Leukocyte Elastase