title: The role of SHIP in growth factor induced signalling.
abstract: The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5' phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more widely expressed counterpart, SHIP2, could play a central role in determining PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo function of SHIP further we recently generated a SHIP knock out mouse and in this review we discuss experiments carried out with bone marrow derived mast cells (BMMCs) from these animals.
authors.affiliation: Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Huber
authors.forename: C D
authors.initials: CD
authors.lastname: Helgason
authors.forename: J E
authors.initials: JE
authors.lastname: Damen
authors.forename: M
authors.initials: M
authors.lastname: Scheid
authors.forename: V
authors.initials: V
authors.lastname: Duronio
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: M D
authors.initials: MD
authors.lastname: Ware
authors.forename: R K
authors.initials: RK
authors.lastname: Humphries
authors.forename: G
authors.initials: G
authors.lastname: Krystal
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010716:Phosphatidylinositols / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015398:Signal Transduction; D018909:src Homology Domains
chemical_list: D006133:Growth Substances; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases