Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position.
Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1 ,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the anti-rhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed.
Hamdouchi
C
C
Centro de Investigación Lilly S.A., Alcobendas (Madrid)-Spain. hamdouchi_chafiq@lilly.com
Ezquerra
J
J
Vega
J A
JA
Vaquero
J J
JJ
Alvarez-Builla
J
J
Heinz
B A
BA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012229:Rhinovirus / Q000187:drug effects*
D000998:Antiviral Agents; D011725:Pyridines