Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise.
Exercise induces a selective redistribution of CD62L(-) T lymphocytes. This study examined the effects of beta adrenergic receptor blockade on this phenomenon. Twelve healthy men were exercised to exhaustion on a treadmill prior to and following 1 week of treatment with the nonselective beta antagonist propranolol or the beta1 selective antagonist metoprolol. Dynamic exercise resulted in a significant lymphocytosis (p < 0.001). CD8(+)CD62L(-) T cells showed a greater than 3-fold increase in response to exercise (p < 0.001) as compared to CD8(+)CD62L(+) T cells, which showed a more modest increase. Treatment with the nonselective beta antagonist propranolol significantly attenuated the preferential increase of circulating CD8(+)CD62L(-) lymphocytes (p = 0.01) but had no effect on CD8(+)CD62L(+) T cells. Treatment with the beta1 selective antagonist metoprolol did not affect the response of either subset. Our findings replicate a prior study indicating that CD62L expression influences T lymphocyte trafficking in response to exercise and extends those findings by showing that this phenomenon is mediated, in part, via the beta2-adrenergic receptor.
Mills
P J
PJ
Department of Psychiatry, University of California, San Diego, USA. pmills@ucsd.edu
Rehman
J
J
Ziegler
M G
MG
Carter
S M
SM
Dimsdale
J E
JE
Maisel
A S
AS
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019041:L-Selectin / Q000032:analysis*; D018655:Lymphocyte Count / Q000187:drug effects; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D019041:L-Selectin; D011433:Propranolol; D008790:Metoprolol