S1319: a novel beta2-andrenoceptor agonist from a marine sponge Dysidea sp.
In the course of screening of potential leads for beta2-receptor agonists, we found a novel beta2-adrenoceptor selective agonist, S1319, from a marine sponge Dysidea sp. The active compound was isolated and structurally characterized as 4-hydroxy-7-[1-(1-hydroxy-2-methylamino)ethyl]-1,3-benzothiazole-2(3H)-o ne, a new member of the beta2-adrenoceptor agonist. This is the first example of a sponge-derived beta2-adrenoceptor agonist.
Suzuki
H
H
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, Gunma, Japan.
Shindo
K
K
Ueno
A
A
Miura
T
T
Takei
M
M
Sakakibara
M
M
Fukamachi
H
H
Tanaka
J
J
Higa
T
T
D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D000818:Animals; D052160:Benzothiazoles; D001667:Binding, Competitive; D004983:Ethanolamines / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009126:Muscle Relaxation / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D011412:Propanolamines / Q000378:metabolism; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D014132:Trachea / Q000187:drug effects / Q000502:physiology
C120088:4-hydroxy-7-(1-(1-hydroxy-2-methylamino)ethyl)-1,3-benzothiazole-2(3H)-one; D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D052160:Benzothiazoles; D004983:Ethanolamines; D011412:Propanolamines; D018343:Receptors, Adrenergic, beta-2; D013844:Thiazoles; C033394:CGP 12177