GM1 produces attenuation of short-term memory deficits in Hebb-Williams maze performance after unilateral entorhinal cortex lesions.
The Hebb-Williams maze was used to examine spatial abilities of adult male Sprague-Dawley rats with unilateral electrolytic entorhinal cortex lesions. The injured rats were treated for 14 days with either saline or ganglioside GM1. Testing was begun 7 weeks following injury, and involved 12 maze problems with independent configurations, with immediate starting replacement used for the six trials per problem. Compared to sham-operated counterparts, the rats with lesion plus saline treatment were impaired in total number of errors, initial entry errors, and repeat errors over 12 consecutive problems. GM1-treated rats showed improved performance, making significantly fewer total and repeat errors, indicating that this substance may be potentially useful as therapy after entorhinal cortex injury.
Glasier
M M
MM
Institute of Animal Behavior, Department of Psychology, Rutgers, the State University of New Jersey, Newark, USA. mglasier@bgsm.edu
Janis
L S
LS
Goncalves
M I
MI
Stein
D G
DG
D000704:Analysis of Variance; D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D003463:Cues; D004195:Disease Models, Animal; D018728:Entorhinal Cortex / Q000187:drug effects / Q000293:injuries*; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D008570:Memory, Short-Term / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009949:Orientation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D018696:Neuroprotective Agents; D005677:G(M1) Ganglioside