Systemic replacement therapy from genetically modified epidermal keratinocytes.
Epidermal keratinocytes are a potential vehicle for gene transfer and systemic delivery. We review data showing that epidermis-secreted protein does indeed reach the circulation, and we discuss factors that bear upon the issue of how much protein epidermal keratinocytes can deliver to the circulation.
Taichman
L B
LB
Department of Dermatology and Oral Biology and Pathology, State University of New York at Stony Brook, NY 11794-8702, USA.
D000818:Animals; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity; D015870:Gene Expression; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism
D001798:Blood Proteins; D011506:Proteins