title: Do acute lesions of Wernicke's encephalopathy show contrast enhancement? Report of three cases and review of the literature.
abstract: Contrast medium was given intravenously to three nonalcoholic patients who underwent MRI or CT in the acute stage of Wernicke's encephalopathy. Lesions enhancement was not seen in one patient examined within 4 days of clinical onset, was mild in a another 3 days after clinical deterioration and marked in a patient examined 12 days after admission. Contrast enhancement of lesions was present in half of 12 cases of acute disease reported previously. There was a substantial overlap in the time interval between clinical onset and contrast-enhanced CT or MRI in the groups of enhancing and nonenhancing lesions. Since contrast enhancement may be absent in acute WE, proton-density and T2-weighted images are more useful for diagnosis of this reversible but potentially fatal condition.
authors.affiliation: Cattedra di Radiologia, Università di Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mascalchi
authors.forename: P
authors.initials: P
authors.lastname: Simonelli
authors.forename: C
authors.initials: C
authors.lastname: Tessa
authors.forename: F
authors.initials: F
authors.lastname: Giangaspero
authors.forename: P
authors.initials: P
authors.lastname: Petruzzi
authors.forename: L
authors.initials: L
authors.lastname: Bosincu
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: G
authors.initials: G
authors.lastname: Sechi
authors.forename: F
authors.initials: F
authors.lastname: Salvi
mesh_terms: D000208:Acute Disease; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014899:Wernicke Encephalopathy / Q000175:diagnosis* / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA