title: Endometrial estrogen and progesterone receptor and pinopode expression in stimulated cycles of oocyte donors.
abstract: OBJECTIVE
  To study the effect of controlled ovarian hyperstimulation and the ovarian response on several features of endometrial morphology simultaneously.
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  Academic infertility center.
  
  
  METHODS
  Twenty-five oocyte donors undergoing COH and 10 ovulatory controls.
  
  
  METHODS
  Endometrial biopsies during the luteal phase and measurement of serum E2 and progesterone levels on days 12, 13, and 18-20.
  
  
  METHODS
  Endometrial morphology as judged by histologic dating, pinopode expression, and estrogen and progesterone receptor content.
  
  
  RESULTS
  Controlled ovarian hyperstimulation caused the early expression of endometrial features as judged by histologic dating criteria, estrogen and progesterone receptor expression, and the timing of pinopode expression in many of the subjects. A significant correlation within subjects with regard to their particular result on any one measure (e.g., histologic examination) and the others (e.g., estrogen and progesterone receptors, pinopodes) was observed. Those with higher levels of progesterone the day after hCG administration exhibited the most prematurity of morphologic features.
  
  
  CONCLUSIONS
  Many controlled ovarian hyperstimulation cycles are associated with synchronous early expression of the expected pattern of histologic features, estrogen and progesterone receptors, and pinopodes. The most predictive feature of this premature expression was the level of progesterone the day after hCG administration.
authors.affiliation: The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk 23507-1627, USA.
authors.forename: O H
authors.initials: OH
authors.lastname: Develioglu
authors.forename: J G
authors.initials: JG
authors.lastname: Hsiu
authors.forename: G
authors.initials: G
authors.lastname: Nikas
authors.forename: J P
authors.initials: JP
authors.lastname: Toner
authors.forename: S
authors.initials: S
authors.lastname: Oehninger
authors.forename: H W
authors.initials: HW
authors.lastname: Jones
mesh_terms: D001706:Biopsy; D002462:Cell Membrane / Q000648:ultrastructure; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004717:Endometrium / Q000378:metabolism* / Q000648:ultrastructure*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008855:Microscopy, Electron, Scanning; D018587:Oocyte Donation; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D006063:Chorionic Gonadotropin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol