title: Combined use of Orgaran and Reopro during coronary angioplasty in patients unable to receive heparin.
abstract: Orgaran, a heparinoid, has been used successfully in patients with heparin-induced thrombocytopenia. We report three cases in which Orgaran was combined with the glycoprotein IIbIIa receptor antagonist Reopro during coronary angioplasty. Orgaran was given as a single intravenous bolus of 1500 anti-factor Xa units. No ischemic or hemorrhagic complications occurred during or following the procedure.
authors.affiliation: Department of Internal Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
authors.forename: W J
authors.initials: WJ
authors.lastname: Cantor
authors.forename: K
authors.initials: K
authors.lastname: Leblanc
authors.forename: B
authors.initials: B
authors.lastname: Garvey
authors.forename: K R
authors.initials: KR
authors.lastname: Watson
authors.forename: A
authors.initials: A
authors.lastname: Rasymas
authors.forename: B H
authors.initials: BH
authors.lastname: Strauss
mesh_terms: D000077284:Abciximab; D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000925:Anticoagulants / Q000627:therapeutic use*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D003327:Coronary Disease / Q000628:therapy*; D003871:Dermatan Sulfate / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006496:Heparinoids / Q000627:therapeutic use*; D006497:Heparan Sulfate / Q000627:therapeutic use*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
chemical_list: D000077284:Abciximab; D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; C035838:danaparoid