title: The impact of first-line antihypertensive drugs on erectile dysfunction.
abstract: Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihypertensive agents are less frequently associated with sexual dysfunction than diuretics or beta-blockers. However, nearly every first-line antihypertensive drug has been reported to cause some degree of erectile dysfunction. Management options include lifestyle modification, dosage reduction, discontinuation of the offending agent, switching to an alternative drug, and pharmacologic therapy.
authors.affiliation: Department of Pharmacy Practice, University of Arkansas for Medical Sciences College of Pharmacy, Little Rock 72211, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Barksdale
authors.forename: S F
authors.initials: SF
authors.lastname: Gardner
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D015897:Comorbidity; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology / Q000209:etiology; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D008297:Male; D008954:Models, Biological; D010947:Plants, Toxic; D014026:Nicotiana / Q000009:adverse effects
chemical_list: D000959:Antihypertensive Agents; D000431:Ethanol