[Clinico-immunobiochemical monitoring of factors of focal inflammation in the acute period of hemispheric ischemic stroke].
The changes of cytokinis status and C-reactive protein were evaluated in cerebrospinal fluid of 50 patients in the acute period of ischemic hemispheric stroke with consideration of influence of the remote consequences of the ischemia, established experimentally, on the mechanisms of cerebral infarction development as well as on the progression of both atherogenesis and vascular encephalopathy in the period after the stroke. Significance both of a surplus releasing of the proinflammatory cytokines and deficiency of the protective antiinflammatory and trophotropic factors in the development of an inflammatory response was established. Immunobiochemical criteria were proposed for grading of process for stroke course prediction and for recovery of the altered neurologic functions. More favourable prognosis was anticipated in the patients in which a the treatment started within of the "therapeutic window".
Skvortsova
V I
VI
Nasonov
E L
EL
Zhuravleva
E Iu
EIu
Grivennikov
I A
IA
Arsen'eva
E L
EL
Sukhanov
I I
II
Miasoedov
N F
NF
Gusev
E I
EI
D000208:Acute Disease; D000210:Acute-Phase Reaction; D000368:Aged; D001921:Brain / Q000098:blood supply* / Q000276:immunology*; D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology*; D002545:Brain Ischemia / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000276:immunology*; D016207:Cytokines / Q000134:cerebrospinal fluid / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D013997:Time Factors
D016207:Cytokines