title: 1999 Gary J. Becker Young Investigator Award. MR-guided transjugular portosystemic shunt placement in a swine model.
abstract: OBJECTIVE
  To evaluate the performance of portal venous puncture with use of magnetic resonance (MR) guidance, and to place a transjugular intrahepatic portosystemic shunt (TIPS) in a swine model.
  
  
  METHODS
  A study of 12 swine was performed to evaluate the ability of interventional MR imaging to guide portal vein puncture and TIPS placement. Six swine had catheters placed in the right hepatic vein under C-arm fluoroscopy. A nitinol guide wire was left in the vein and the animals were then moved into an open configuration MR imaging unit. A TIPS needle set was used to puncture the portal vein using MR fluoroscopy. The animals were transferred to the C-arm, and venography confirmed portal vein puncture. A follow-up study was performed in six additional swine to place a TIPS using only MR imaging guidance. MR tracking was used to advance a catheter from the right atrium into the inferior vena cava. Puncture of the portal vein was performed and a nitinol stent was placed, bridging the hepatic parenchyma. MR venogram confirmed placement.
  
  
  RESULTS
  Successful portal vein puncture was achieved in all animals. The number of punctures required decreased from 12 in the first animal to a single puncture in the last eight swine. A stent was successfully placed across the hepatic tract in all six swine.
  
  
  CONCLUSIONS
  Real-time MR imaging proved to be a feasible method to guide portal vein puncture and TIPS placement in pigs.
authors.affiliation: Department of Radiology, Stanford University School of Medicine, California, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Kee
authors.forename: J S
authors.initials: JS
authors.lastname: Rhee
authors.forename: K
authors.initials: K
authors.lastname: Butts
authors.forename: B
authors.initials: B
authors.lastname: Daniel
authors.forename: J
authors.initials: J
authors.lastname: Pauly
authors.forename: A
authors.initials: A
authors.lastname: Kerr
authors.forename: G J
authors.initials: GJ
authors.lastname: O'Sullivan
authors.forename: D Y
authors.initials: DY
authors.lastname: Sze
authors.forename: M K
authors.initials: MK
authors.lastname: Razavi
authors.forename: C P
authors.initials: CP
authors.lastname: Semba
authors.forename: R J
authors.initials: RJ
authors.lastname: Herfkens
authors.forename: M D
authors.initials: MD
authors.lastname: Dake
mesh_terms: D000818:Animals; D001363:Awards and Prizes; D008279:Magnetic Resonance Imaging; D018962:Phlebotomy / Q000379:methods; D011169:Portal Vein; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D015642:Radiology, Interventional; D012955:Societies, Medical; D013552:Swine; D014481:United States