Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud. wood oil.
The volatile oil extracted by steam distillation of the wood of Cedrus deodara was examined for its oral anti-inflammatory and analgesic activity at the doses of 50 and 100 mg/kg body weight. It produced significant inhibition of carrageenan-induced rat paw edema and of both exudative-proliferative and chronic phases of inflammation in adjuvant arthritic rats at doses of 50 and 100 mg/kg body weight. The oil at both tested doses was found to possess analgesic activity against acetic acid-induced writhing and hot plate reaction in mice.
Shinde
U A
UA
Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, India.
Phadke
A S
AS
Nair
A M
AM
Mungantiwar
A A
AA
Dikshit
V J
VJ
Saraf
M N
MN
D019342:Acetic Acid / Q000009:adverse effects; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D002351:Carrageenan / Q000009:adverse effects; D004487:Edema / Q000188:drug therapy*; D007249:Inflammation / Q000139:chemically induced; D051379:Mice; D009821:Oils / Q000627:therapeutic use; D010147:Pain Measurement / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009821:Oils; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid