title: Excess abdominal adiposity remains correlated with altered lipid concentrations in healthy older women.
abstract: OBJECTIVE
  To determine associations between overall adiposity, absolute and relative abdominal adiposity, and lipid concentrations in healthy older women.
  
  
  METHODS
  Cross-sectional analysis of baseline data.
  
  
  METHODS
  Subjects were 21 healthy, untrained older women (71 +/- 1 y) entering a randomized, controlled aerobic training program.
  
  
  METHODS
  Overall adiposity was assessed by anthropometry and the body mass index (BMI=kg/m2). Absolute and relative abdominal adiposity was determined by computed tomography (CT) and circumference measures. Fasting serum lipid concentrations of total-, high density lipoprotein (HDL)-, and low density lipoprotein (LDL)-cholesterol (C) and triglycerides (TGs) were determined by standard enzymatic procedures.
  
  
  RESULTS
  Compared to the measures of overall adiposity, we observed much stronger correlations between measures more specific to absolute or relative abdominal adiposity and lipid concentrations. Visceral fat area was the strongest correlate of HDL-C (r = -0.75; P < 0.001) and the total-/HDL-C ratio (r = 0.86; P < 0.001). The abdomen-to-hip circumference ratio (AHR) was strongly correlated with TGs (r = 0.54; P < 0.01), HDL-C (r= -0.69; P < 0.001), and the total-/HDL-C ratio (r = 0.75; P < 0.001).
  
  
  CONCLUSIONS
  Excess abdominal adiposity remains an important correlate of lipid metabolism, even in healthy older women of normal weight. Thus, overall obesity is not a necessary condition for the correlation between excess abdominal fat and metabolic risk among postmenopausal women.
authors.affiliation: The John B. Pierce Laboratory, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: L
authors.initials: L
authors.lastname: DiPietro
authors.forename: L D
authors.initials: LD
authors.lastname: Katz
authors.forename: E R
authors.initials: ER
authors.lastname: Nadel
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue; D000368:Aged; D000375:Aging; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides