title: Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate.
abstract: Plasma total homocysteine response was compared in four groups of healthy individuals given orally divided doses of vitamin supplementations for a duration of 5 weeks. The vitamin supplements; A, 0.3 mg folic acid; B, 120 mg vitamin B6; C, combination of 0.3 mg folic acid and 120 mg vitamin B6 or D, 0.6 mg folic acid reduced the concentrations of plasma total homocysteine 20, 17, 32 and 24%, respectively. However, the intergroup comparisons did not show a significant difference in the effects of vitamin supplements. Multivariate analysis with correction for differences in pre-supplement values indicated a significant effect of vitamin B6 supplementation on plasma total homocysteine and serum folate. Our data show that plasma total homocysteine concentrations are reduced with low to medium divided doses of folic acid alone or in combination with vitamin B6.
authors.affiliation: Department of Clinical Chemistry, Central Hospital in Rogaland, Stavanger, Norway.
authors.forename: M A
authors.initials: MA
authors.lastname: Mansoor
authors.forename: O
authors.initials: O
authors.lastname: Kristensen
authors.forename: T
authors.initials: T
authors.lastname: Hervig
authors.forename: C J
authors.initials: CJ
authors.lastname: Bates
authors.forename: K
authors.initials: K
authors.lastname: Pentieva
authors.forename: H
authors.initials: H
authors.lastname: Vefring
authors.forename: A
authors.initials: A
authors.lastname: Osland
authors.forename: T
authors.initials: T
authors.lastname: Berge
authors.forename: P A
authors.initials: PA
authors.lastname: Drabløs
authors.forename: O
authors.initials: O
authors.lastname: Hetland
authors.forename: S
authors.initials: S
authors.lastname: Rolfsen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002784:Cholesterol / Q000097:blood; D003545:Cysteine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000494:pharmacology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009664:Norway; D011732:Pyridoxal Phosphate / Q000097:blood; D011735:Pyridoxic Acid / Q000097:blood; D011736:Pyridoxine / Q000008:administration & dosage / Q000494:pharmacology*; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D004151:Dipeptides; D008074:Lipoproteins; D006710:Homocysteine; C028505:cysteinylglycine; D011735:Pyridoxic Acid; D011732:Pyridoxal Phosphate; C022291:cystinylglycine; D005492:Folic Acid; D002784:Cholesterol; D003545:Cysteine; D011736:Pyridoxine; D014805:Vitamin B 12