What is the relevance of apoptosis to the myocardium?
Direct and indirect evidence from a number of studies demonstrates that apoptosis is an important process in heart failure in humans. It is thought that a proapoptotic shift in conditions occurs during heart failure, involving the entire population of cardiac myocytes. A complex mechanism of programmed cell death has been postulated, involving such factors as Fas, Bax and Bcl-2; tumour necrosis may also play a role. Given the myriad apoptotic pathways, a number of opportunities for treatment have been identified.
Liu
P
P
The Toronto Hospital and University of Toronto, Toronto, Canada. peter.liu@utoronto.ca
Sole
M J
MJ
D017209:Apoptosis; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha
D014409:Tumor Necrosis Factor-alpha