Glucotoxicity: potential mechanisms.
Plasma concentration of glucose is found within a relatively narrow range of values for most animal species, yet it has little correlation with maximum lifespan; however, hyperglycemia in most animals is associated with premature death. This article presents evidence for hyperglycemia-induced tissue toxicity and discusses potential mechanisms of glucotoxicity and implications for the aging organism.
Mooradian
A D
AD
Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.
Thurman
J E
JE
D000367:Age Factors; D000368:Aged; D000818:Animals; D048909:Diabetes Complications; D005260:Female; D005947:Glucose / Q000009:adverse effects / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D018384:Oxidative Stress; D018570:Risk Assessment
D005947:Glucose