Induction of neutralizing autoantibodies to interferon-gamma in patients with polyneuropathy.
We previously demonstrated the induction of IFN-gamma in polyneuropathy patients associated with monoclonal gammopathy, but not in patients with presumably non-immunological types of neuropathy. We herein examined mechanism involving release of neutralizing autoantibodies (Aabs) to IFN-gamma in sera from those patients. In contrast to polyneuropathy patients with monoclonal gammopathy, patients with polyneuropathy of presumably non-immunological types showed increased production of neutralizing Aabs specific for IFN-gamma. These results demonstrate a role for autoimmunity in cytokine regulation. However, their association to the clinical manifestations of the disease requires further investigations, which are necessary for future consideration in therapeutic strategies.
Elkarim
R A
RA
Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Mustafa
M
M
Link
H
H
Bakhiet
M
M
Ekerfelt
C
C
Vrethem
M
M
Ernerudh
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000276:immunology*; D009500:Neutralization Tests; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000276:immunology*
D001323:Autoantibodies; D007371:Interferon-gamma