title: [The efficacy and outlook for the study of live vaccines for the prevention of melioidosis].
abstract: The effect of immunization with Burkholderia pseudomallei, (Pur- and Ts), heterologous vaccines and the recombinant culture of Francisella tularensis RM2, carrying a plasmid with fragments of B. pseudomallei chromosome, was studied on four species of experimental animals, essentially differing by their sensitivity to melioidosis. B. pseudomallei mutants formed the statistically significant level of protection in subcutaneously challenged animals, moderately sensitive to melioidosis, but were not effective when tested, under the same conditions, in animals, highly sensitive to melioidosis. The effect produced by the experimental vaccines under study in animals of all species, subjected to aerogenic challenge, was leveled. The study showed good prospects for the use of tularemia vaccine with a view to create heterologous immunity to melioidosis and the possibility of its use as the basis of bivalent gene engineering vaccine.
authors.affiliation: Research Institute for Plague Control, Volgograd, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Iliukhin
authors.forename: N N
authors.initials: NN
authors.lastname: Kislichkin
authors.forename: L K
authors.initials: LK
authors.lastname: Merinova
authors.forename: L A
authors.initials: LA
authors.lastname: Riapis
authors.forename: I I
authors.initials: II
authors.lastname: Denisov
authors.forename: S M
authors.initials: SM
authors.lastname: Farber
authors.forename: O I
authors.initials: OI
authors.lastname: Kislichkina
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000633:toxicity; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D002876:Chromosomes, Bacterial / Q000235:genetics; D004353:Drug Evaluation, Preclinical; D005604:Francisella tularensis / Q000235:genetics / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D008554:Melioidosis / Q000517:prevention & control*; D051379:Mice; D009154:Mutation; D010957:Plasmids / Q000235:genetics; D051381:Rats; D014613:Vaccines, Attenuated / Q000276:immunology / Q000633:toxicity; D017778:Vaccines, Combined / Q000276:immunology / Q000633:toxicity; D014614:Vaccines, Synthetic / Q000276:immunology* / Q000633:toxicity; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014614:Vaccines, Synthetic