title: Clinical and laboratory study of kala-azar in children in Nepal.
abstract: Reports are scanty regarding kala-azar in children in Nepal. In this communication we document 20 children diagnosed to have kala-azar who were admitted and treated at B. P. Koirala Institute of Health Sciences, Dharan, Nepal. The children were between 2 and 14 years old. The duration of illness varied between 12 days and 24 months with a majority (65 per cent) of children being ill for less than 6 months. Hepatomegaly and splenomegaly were seen in 95 and 90 per cent of cases respectively. Splenomegaly was not found in two (10 per cent) children. Anaemia, leucopenia, and thrombocytopenia were seen in 95, 60, and 75 per cent of children respectively. Amastigotes of Leishmania donovani (LD bodies) were demonstrated in Giemsa-stained smears of bone marrow aspirates in 16 (80 per cent) children. All the children responded to treatment with sodium stibogluconate. No mortality was observed. This study emphasizes the importance of kala-azar in children in endemic areas of eastern Nepal.
authors.affiliation: Department of Paediatrics, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. bpkihs@npl.healthnet.org
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: S C
authors.initials: SC
authors.lastname: Parija
authors.forename: M M
authors.initials: MM
authors.lastname: Faridi
authors.forename: N
authors.initials: N
authors.lastname: Bhatta
mesh_terms: D000293:Adolescent; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D009390:Nepal / Q000453:epidemiology; D013163:Splenomegaly / Q000209:etiology
chemical_list: D000981:Antiprotozoal Agents; D000967:Antimony Sodium Gluconate