Novel sorbitan monostearate organogels.
Sorbitan monostearate, a hydrophobic nonionic surfactant, gels a number of organic solvents such as hexadecane, isopropyl myristate, and a range of vegetable oils. Gelation is achieved by dissolving/dispersing the organogelator in hot solvent to produce an organic solution/dispersion, which, on cooling sets to the gel state. Cooling the solution/dispersion causes a decrease in the solvent-gelator affinities, such that at the gelation temperature, the surfactant molecules self-assemble into toroidal inverse vesicles. Further cooling results in the conversion of the toroids into rod-shaped tubules. Once formed, the tubules associate with others, and a three-dimensional network is formed which immobilizes the solvent. An organogel is thus formed. Sorbitan monostearate gels are opaque, thermoreversible semisolids, and they are stable at room temperature for weeks. The gels are affected by the presence of additives such as the hydrophilic surfactant, polysorbate 20, which improves gel stability and alters the gel microstructure from a network of individual tubules to star-shaped "clusters" of tubules in the liquid continuous phase. Another solid monoester in the sorbitan ester family, sorbitan monopalmitate, also gels organic solvents to give opaque, thermoreversible semisolids. Like sorbitan monostearate gels, the microstructure of the palmitate gels comprise an interconnected network of rodlike tubules. Unlike the stearate gels, however, the addition of small amounts of a polysorbate monoester causes a large increase in tubular length instead of the "clustering effect" seen in stearate gels. The sorbitan stearate and palmitate organogels may have potential applications as delivery vehicles for drugs and antigens.
Murdan
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Centre for Drug Delivery Research, School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
Gregoriadis
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Florence
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D002152:Calorimetry, Differential Scanning; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006601:Hexoses / Q000737:chemistry*; D008027:Light; D008051:Lipid Bilayers / Q000737:chemistry; D008853:Microscopy; D011136:Polysorbates / Q000737:chemistry; D012997:Solvents; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction
D005079:Excipients; D005782:Gels; D006601:Hexoses; D008051:Lipid Bilayers; D011136:Polysorbates; D012997:Solvents; D013501:Surface-Active Agents; C009298:sorbitan monostearate