A thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene.
Quash
G
G
Laboratoire d'Immunochimie, INSERM U 329, Faculté de Médecine Lyon-Sud, Oullins, France.
Fournet
G
G
Raffin
C
C
Chantepie
J
J
Michal
Y
Y
Gore
J
J
Reichert
U
U
D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D000447:Aldehydes / Q000138:chemical synthesis / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D053938:DNA Fragmentation; D004791:Enzyme Inhibitors / Q000378:metabolism*; D015870:Gene Expression; D006131:Growth Inhibitors / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D051379:Mice; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D012441:Saccharomyces cerevisiae; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D000447:Aldehydes; D004791:Enzyme Inhibitors; D006131:Growth Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D013438:Sulfhydryl Compounds; C008390:methional; C059170:4-amino-4-methyl-2-pentyne-1-al; D000444:Aldehyde Dehydrogenase