[Changes in functional activity of blood neutrophils in pollenosis patients: effects of specific immunotherapy].
OBJECTIVE
The study of effective and regulatory functions of neutrophilic granulocytes in patients with pollenosis exacerbation, correction of the impaired neutrophil function with standard treatment and specific immunotherapy (SIT).


METHODS
The study included 103 healthy donors (controls) and 122 patients with pollenosis aggravation. 69 of the latter received symptomatic treatment. 53 patients received preseasonal SIT with water-salt extracts of the pollen allergens.


RESULTS
The untreated pollenosis patients had hyperproduction of interleukin-1 (IL-1) by nonstimulated blood neutrophils associated with elevation of NBT-reduction and lowering of phagocytic activity in decreasing count of Fc- and Ca-receptors. Effective SIT produced recovery of phagocytic activity, the number of Fc- and Ca-receptors, IL-1-activity of cell supernatants.


CONCLUSIONS
One of the SIT targets in pollenosis patients is neutrophilic granulocytes.
Ivanova
I P
IP
Tananko
E M
EM
Shirinskiĭ
V S
VS
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007375:Interleukin-1 / Q000096:biosynthesis; D007958:Leukocyte Count; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D011058:Pollen / Q000276:immunology*; D011961:Receptors, Fc / Q000378:metabolism; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000276:immunology / Q000628:therapy
D000485:Allergens; D007375:Interleukin-1; D011961:Receptors, Fc