title: A prospective study of pancreatic disease in patients with alcoholic cirrhosis: comparative diagnostic value of ERCP and EUS and long-term significance of isolated parenchymal abnormalities.
abstract: BACKGROUND
  The prevalence of pancreatic disease in patients with alcohol-related liver cirrhosis is uncertain. We assessed the prevalence of pancreatic abnormalities in patients with alcoholic cirrhosis, and we compared endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) for the detection of chronic pancreatitis and other pancreatic lesions. In addition, we assessed the long-term significance of isolated pancreatic parenchymal abnormalities detected at EUS.
  
  
  METHODS
  EUS and ERCP were performed in each patient. Subjects with minimal parenchymal changes at initial EUS underwent clinical follow-up and subsequent EUS and/or ERCP to document the occurrence, absence, or progression of these changes.
  
  
  RESULTS
  Seventy-two patients with alcoholic cirrhosis were recruited. Chronic pancreatitis was diagnosed in 14 patients (19%) by both methods independently. Isolated parenchymal lesions were observed in 18 patients by EUS alone. After a mean follow-up of 22 months the EUS appearance was unchanged. Ten of the 18 patients underwent follow-up ERCP and this was normal in all cases.
  
  
  CONCLUSIONS
  This study demonstrated that (1) 19% of patients with alcoholic cirrhosis have chronic pancreatitis, (2) an additional 25% have isolated pancreatic parenchymal changes at EUS, and (3) these parenchymal abnormalities do not progress during follow-up.
authors.affiliation: Department of Hepato-Gastroenterology, Hôpital de l'Archet II, Nice, France.
authors.forename: P
authors.initials: P
authors.lastname: Hastier
authors.forename: M J
authors.initials: MJ
authors.lastname: Buckley
authors.forename: E
authors.initials: E
authors.lastname: Francois
authors.forename: E P
authors.initials: EP
authors.lastname: Peten
authors.forename: R
authors.initials: R
authors.lastname: Dumas
authors.forename: F X
authors.initials: FX
authors.lastname: Caroli-Bosc
authors.forename: J P
authors.initials: JP
authors.lastname: Delmont
mesh_terms: D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000379:methods*; D002908:Chronic Disease; D019160:Endosonography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D019512:Pancreatitis, Alcoholic / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity