title: [Non-immunoallergic hepatotoxicity due to mesalazine].
abstract: Mesalazine is an aminosalicillic derivative considered as a safe alternative to the relative frequency (5-55%) of adverse effects observed with sulfasalazine. The well known hepatoxicity associated with sulfasalazine and attributed to its sulfamidic fraction is limited to few cases described in the treatment with mesalazine. We herein present a new case of hepatoxicity by mesalazine in a patient with lymphocytic colitis. The possible pathogenic mechanism is also commented upon.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla.
authors.forename: N
authors.initials: N
authors.lastname: Barroso
authors.forename: E
authors.initials: E
authors.lastname: Leo
authors.forename: A
authors.initials: A
authors.lastname: Guil
authors.forename: J
authors.initials: J
authors.lastname: Larrauri
authors.forename: C
authors.initials: C
authors.lastname: Tirado
authors.forename: C
authors.initials: C
authors.lastname: Zafra
authors.forename: F
authors.initials: F
authors.lastname: Gavilán
authors.forename: F R
authors.initials: FR
authors.lastname: Reina
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D003092:Colitis / Q000150:complications / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes; D019804:Mesalamine / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine