Kaposi's sarcoma-associated herpesvirus infection in the lung in multicentric Castleman's disease.
A 32-year-old female was admitted for evaluation of multiple infiltrates on a chest radiograph. A diagnosis of multicentric Castleman's disease was made on the basis of typical clinical manifestations. Transbronchial lung biopsy (TBLB) revealed histological findings reported in lymphocytic interstitial pneumonia. Both the polymerase chain reaction and in situ hybridization with a probe specific for Kaposi's sarcoma-associated herpesvirus (KSHV) sequences demonstrated the presence of KSHV in the TBLB sample.
Hayashi
M
M
Department of Medicine, Chest Institute Tokyo Women's Medical University.
Aoshiba
K
K
Shimada
M
M
Izawa
Y
Y
Yasui
S
S
Nagai
A
A
D000328:Adult; D001706:Biopsy; D001999:Bronchoscopy; D005871:Castleman Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D017931:DNA Primers / Q000737:chemistry; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D005336:Fiber Optic Technology; D006566:Herpesviridae Infections / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D017403:In Situ Hybridization; D008168:Lung / Q000473:pathology / Q000821:virology; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic
D017931:DNA Primers; D004279:DNA, Viral