Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. II. Structure determination.
The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring optical rotation. The stereochemistry of the aglycon was determined by X-ray crystallographic analysis.
Matsumoto
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Tsuchida
T
T
Nakamura
H
H
Sawa
R
R
Takahashi
Y
Y
Naganawa
H
H
Iinuma
H
H
Sawa
T
T
Takeuchi
T
T
Shiro
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006868:Hydrolysis; D007211:Indoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009285:Naphthoquinones / Q000737:chemistry; D009904:Optical Rotation; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D007211:Indoles; D009285:Naphthoquinones; C102442:lactonamycin