Selection of the T cell repertoire.
Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level. Positive selection refers to the active process of rescuing MHC-restricted thymocytes from programmed cell death. Negative selection refers to the deletion or inactivation of potentially autoreactive thymocytes. This review focuses on interactions during thymocyte maturation that define the T cell repertoire, with an emphasis placed on current literature within this field.
Sebzda
E
E
Ontario Cancer Institute, Toronto, Canada.
Mariathasan
S
S
Ohteki
T
T
Jones
R
R
Bachmann
M F
MF
Ohashi
P S
PS
D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000276:immunology; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002454:Cell Differentiation; D002470:Cell Survival; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D010455:Peptides / Q000276:immunology; D051966:Phospholipase C gamma; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism
D007527:Isoenzymes; D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D018124:Receptors, Tumor Necrosis Factor; D014157:Transcription Factors; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D010738:Type C Phospholipases; D051966:Phospholipase C gamma