Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat.
Interactive effects of gossypol and chloroquine as determined by activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and liver lactate dehydrogenase (LDH), alkaline phosphatase (ALK-pase), glucose-6-phosphatase (G-6-pase) and cholesterol level were investigated in rats. Administration of gossypol for eight weeks, at a concentration of 20 mg per kg body wt. per day with or without chloroquine had no effect on the serum enzymes and glucose-6-phosphatase activities. When chloroquine at a concentration of 5 mg per kg body wt. thrice a week was administered alone, there was a marked decrease in total protein content and ALK-pose activities, while a significant increase in LDH activity was observed. Administration of either gossypol or chloroquine decreased the level of cholesterol. A greater decrease was recorded when both were given together. It is suggested that gossypol can be employed as a male contraceptive among malaria-infected populations.
Achudume
A C
AC
Department of Bio-Chemistry, Obafemi Awolowo University, ILE-IFE, Nigeria.
Adepoju
A Y
AY
Abu
K A
KA
Olanrewaju
I G
IG
D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D002738:Chloroquine / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D006072:Gossypol / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000962:Antimalarials; D002738:Chloroquine; D006072:Gossypol