Identifying inner retinal contributions to the human multifocal ERG.
Contributions to the multifocal electroretinogram (ERG) from the inner retina (i.e. ganglion and amacrine cells) were identified by recording from monkeys before and after intravitreal injections of n-methyl DL aspartate (NMDLA) and/or tetrodotoxin (TTX). Components similar in waveform to those removed by the drugs were identified in the human multifocal ERG if the stimulus contrast was set at 50% rather than the typically employed 100% contrast. These components were found to be missing or diminished in the records from some patients with glaucoma and diabetes, diseases which affect the inner retina.
Hood
D C
DC
Department of Psychology, Columbia University, New York, NY 10027, USA. don@psych.columbia.edu
Greenstein
V
V
Frishman
L
L
Holopigian
K
K
Viswanathan
S
S
Seiple
W
W
Ahmed
J
J
Robson
J G
JG
D000328:Adult; D000818:Animals; D003930:Diabetic Retinopathy / Q000503:physiopathology; D004596:Electroretinography / Q000187:drug effects*; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006801:Humans; D008253:Macaca mulatta; D008875:Middle Aged; D016202:N-Methylaspartate / Q000494:pharmacology; D010364:Pattern Recognition, Visual / Q000502:physiology; D012160:Retina / Q000502:physiology* / Q000503:physiopathology; D012165:Retinal Ganglion Cells / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D016202:N-Methylaspartate