title: [The influence of nitrates on platelet oxygen metabolism: in vitro studies].
abstract: Our investigations were carried out on human blood platelets obtained from persons aged 20-23, free from any systemic diseases. Drugs were incubated with blood platelets. Changes of antioxidant enzymes were detected. Glyceryl trinitrate increased the activity of Zn Cu-SOD (4.62%) and GPx (275.91%), concentration of ATP (13.01%) and the blood platelets aggregations (17.88%). Izosorbide dinitrate increased the activity of ZnCu-SOD (19.46%), GPx (150.36%) and Cat (15.62%), increased concentration of ATP (23.73%) and blood platelets aggregation (3.64%). Both preparats decreased concentration of MDA (Sustonit--30.79%, Iso-Mack--35.04%). Gliceryl trinitrate decreased the activity of catalase otherwise izosorbide dinitrate increased the activity of this enzyme.
authors.affiliation: Zakładu Medycyny Zapobiegawczej Instytutu OOZW WAM w Lodzi.
authors.forename: A
authors.initials: A
authors.lastname: Buczyński
authors.forename: M
authors.initials: M
authors.lastname: Dziedziczak-Buczyńska
authors.forename: W
authors.initials: W
authors.lastname: Gnitecki
authors.forename: J
authors.initials: J
authors.lastname: Kocur
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D009566:Nitrates / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D009566:Nitrates; D010100:Oxygen