Recurrent convulsions and cardiac conduction disturbances after propafenone overdose.
Propafenone is a class Ic antiarrhythmic agent which also exhibits beta-adrenergic and fast sodium channel blockade. We report a case of severe poisoning in a 24-y-old woman who suffered a seizure 1 h after the intentional ingestion of 2.7 g propafenone, and had a recurrence of convulsion on arrival at the hospital. She also developed severe arrhythmia during her hospital course. She recovered uneventfully with supportive treatment.
Rambourg-Schepens
M O
MO
Clinical Toxicology Unit-Toxicovigilance/Intensive Care Unit, Centre Hospitalier Universitaire, Reims, France.
Grossenbacher
F
F
Buffet
M
M
Lamiable
D
D
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000506:poisoning*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D011405:Propafenone / Q000506:poisoning*; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced* / Q000628:therapy
D000889:Anti-Arrhythmia Agents; D011405:Propafenone