title: Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery.
abstract: The purpose of this study was to determine the effect of dietary Mg deficiency (80 mg/kg versus control diet: 960 mg/kg) on blood pressure and mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously with an echo-tracking device. At 19 weeks, systolic, diastolic, and mean blood pressures were higher in Mg-deficient rats. Histological examination showed an increase in cross-sectional area, intima-media thickness, and media-to-lumen ratio in carotid artery of Mg-deficient rats. Mg deficiency did not modify the arterial distensibility-blood pressure curve. At mean blood pressure, arterial distensibility was significantly less in 19-week-old rats than in 5-week-old rats of both control and Mg-deficient groups. A significant interaction between age and Mg-deficient diet on arterial distensibility (P<0.04) indicates an accelerated age-dependent decreased arterial distensibility with Mg deficiency. At 19 weeks, the artery was stiffer in hypertensive Mg-deficient rats, as illustrated by a shift to higher levels of the incremental elastic modulus-stress curve. In conclusion, the increased blood pressure and the vascular morphological alterations observed in Mg-deficient rats may contribute to an accelerated alteration of the wall material, which in turn leads to a stiffening of the carotid artery.
authors.affiliation: Laboratoire Physiologie, Pharmacologie, et Nutrition Pr&eacute. pascal.laurant@univ-fcomte.fr
authors.forename: P
authors.initials: P
authors.lastname: Laurant
authors.forename: D
authors.initials: D
authors.lastname: Hayoz
authors.forename: H R
authors.initials: HR
authors.lastname: Brunner
authors.forename: A
authors.initials: A
authors.lastname: Berthelot
mesh_terms: D000367:Age Factors; D000818:Animals; D001696:Biomechanical Phenomena; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D004548:Elasticity; D006439:Hemodynamics; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014463:Ultrasonography
chemical_list: D002784:Cholesterol; D008274:Magnesium; D002118:Calcium