title: Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing.
abstract: This study evaluated the antimicrobial activity of ACTICOAT Antimicrobial Barrier Dressing (Westaim Biomedical Corp, Fort Saskatchewan, Alberta, Canada), a silver-coated wound dressing, and compared it with silver nitrate, silver sulfadiazine, and mafenide acetate. The minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC), zone of inhibition, and killing curves were determined with 5 clinically relevant bacteria. The data indicate that ACTICOAT silver had the lowest MIC and MBC and generated similar zones of inhibition to silver nitrate and silver sulfadiazine. Viable bacteria were undetectable 30 minutes after inoculation with the dressing, whereas it took 2 to 4 hours for silver nitrate and silver sulfadazine to achieve the same result. Mafenide acetate generated the biggest zones of inhibition, but it had the highest MICs and MBCs, and a significant number of bacteria still survived after 6 hours of treatment. The results suggest that ACTICOAT Antimicrobial Barrier Dressing has better antimicrobial performance than either of the existing silver-based products. ACTICOAT dressing killed the bacteria that were tested much faster, which is a very important characteristic for a wound dressing acting as a barrier to invasive infection to have. The study also suggests that a single susceptibility test such as a MIC or zone of inhibition test does not provide a comprehensive profile of antimicrobial activity of a topical antimicrobial agent or dressing. A combination of tests is desirable.
authors.affiliation: Westaim Biomedical Corp, Fort Saskatchewan, Alberta, Canada.
authors.forename: H Q
authors.initials: HQ
authors.lastname: Yin
authors.forename: R
authors.initials: R
authors.lastname: Langford
authors.forename: R E
authors.initials: RE
authors.lastname: Burrell
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001458:Bandages; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008272:Mafenide / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011091:Polyesters / Q000494:pharmacology*; D011095:Polyethylenes / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012835:Silver Nitrate / Q000494:pharmacology; D012837:Silver Sulfadiazine / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: C117408:Acticoat; D000891:Anti-Infective Agents, Local; D011091:Polyesters; D011095:Polyethylenes; D008272:Mafenide; D012835:Silver Nitrate; D012837:Silver Sulfadiazine