title: The role of photodynamic therapy in dermatology.
abstract: Photodynamic therapy (PDT) involves selective photosensitization of a target tissue by means of a topically or systemically administered agent which is then activated by light to effect an oxygen dependent cytotoxic reaction. The production of reactive oxygen intermediates, including singlet oxygen, is localized to where the photosensitizer accumulates and induces apoptosis and vascular endothelial damage. First-generation photosensitizers are haematoporphyrin derivatives and are effective in treating certain nonmelanoma skin cancers. However, they induce cutaneous photosensitization for at least 4-6 weeks and have a limited role in dermatology. Many second-generation photosensitizers, such as 5-aminolaevulinic acid, are associated with less prolonged photosensitization. Although PDT remains largely experimental, it has potential applications in both benign and malignant skin disease.
authors.affiliation: Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
authors.forename: H A
authors.initials: HA
authors.lastname: Kurwa
authors.forename: R J
authors.initials: RJ
authors.lastname: Barlow
mesh_terms: D002280:Basal Cell Carcinoma / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005260:Female; D006628:Hirsutism / Q000188:drug therapy; D006801:Humans; D007642:Keratosis / Q000188:drug therapy; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents