Four cases of follicular lymphoma with t(14;18)(q32;q21) and t(3;4)(q27;p13) with LAZ3 (BCL6) rearrangement.
We report four cases of follicular lymphoma with both t(14;18)(q32;q21) and the newly characterized t(3;4)(q27;p13). Molecular investigation confirmed LAZ3 (BCL6) rearrangement for all patients. The 3q27 aberrations have been rarely described in low-grade lymphomas and may represent secondary events whose implication remains to be elucidated.
Daudignon
A
A
Département d'Hématologie-Immunologie-Cytogénétique, Centre Hospitalier de Valenciennes, France.
Bisiau
H
H
Le Baron
F
F
Laï
J L
JL
Wetterwald
M
M
Galiègue-Zouitina
S
S
Morel
P
P
Duthilleul
P
P
D000328:Adult; D000368:Aged; D015139:Blotting, Southern; D002877:Chromosomes, Human; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007621:Karyotyping; D008224:Lymphoma, Follicular / Q000188:drug therapy / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D014157:Transcription Factors