title: Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
abstract: We report two cases of HIV-infected patients who presented with diffuse interstitial micronodular lesions on chest X-ray after institution of protease inhibitor-containing highly active antiretroviral therapy (HAART). Granulomatous pulmonary disorder mimicking sarcoidosis was diagnosed on histopathological studies revealing noncaseating granuloma and bronchoalveolar lavage analysis showing an intense CD4(+) lymphocyte alveolitis. Causative agents such as infectious organisms and environmental compounds were excluded. The relationship between sarcoid-like reaction and immune reconstitution under HAART is discussed.
authors.affiliation: Services de Pneumologie et de Réanimation Respiratoire, d'Anatomie-Pathologique, et d'Histologie Biologie Tumorale, Hôpital Tenon, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Naccache
authors.forename: M
authors.initials: M
authors.lastname: Antoine
authors.forename: M
authors.initials: M
authors.lastname: Wislez
authors.forename: J
authors.initials: J
authors.lastname: Fleury-Feith
authors.forename: E
authors.initials: E
authors.lastname: Oksenhendler
authors.forename: C
authors.initials: C
authors.lastname: Mayaud
authors.forename: J
authors.initials: J
authors.lastname: Cadranel
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000139:chemically induced* / Q000473:pathology*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000473:pathology*
chemical_list: D019380:Anti-HIV Agents