Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Lactonamycin (1) was isolated from a culture broth of Streptomyces rishiriensis MJ773-88K4. Antibiotic 1 exhibited antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Matsumoto
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Tsuchida
T
T
Maruyama
M
M
Kinoshita
N
N
Homma
Y
Y
Iinuma
H
H
Sawa
T
T
Hamada
M
M
Takeuchi
T
T
Heida
N
N
Yoshioka
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D000970:Antineoplastic Agents / Q000494:pharmacology; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D016106:Methicillin Resistance; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D013302:Streptomyces / Q000145:classification / Q000254:growth & development / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D007211:Indoles; D009285:Naphthoquinones; C102442:lactonamycin; D014640:Vancomycin