title: Improvements in human health through production of human milk proteins in transgenic food plants.
abstract: Plants are particularly suitable bioreactors for the production of proteins, as their eukaryotic nature frequently directs the appropriate post-translational modifications of recombinant proteins to retain native biological activity. The autotrophic growth of plants makes this in vivo biosynthesis system economically competitive for supplementation or replacement of conventional production systems in the future. For the production of biologically active proteins, food plants provide the advantage of direct delivery via consumption of transformed plant tissues. Here we describe the production of recombinant human milk proteins in food plants for improvements in human nutrition and health, with emphasis on enhanced nutrition for non-breast fed infants as well as children and adults. Nutritional improvements in edible plants generated through advancements in recombinant DNA technology are rapidly repositioning the world for enjoyment of a more healthful diet for humans in all age groups.
authors.affiliation: Center for Molecular Biology and Gene Therapy, Loma Linda University, California 92350, USA.
authors.forename: T
authors.initials: T
authors.lastname: Arakawa
authors.forename: D K
authors.initials: DK
authors.lastname: Chong
authors.forename: C W
authors.initials: CW
authors.lastname: Slattery
authors.forename: W H
authors.initials: WH
authors.lastname: Langridge
mesh_terms: D000328:Adult; D000818:Animals; D019149:Bioreactors; D002364:Caseins / Q000096:biosynthesis; D002417:Cattle; D006801:Humans; D007768:Lactalbumin / Q000096:biosynthesis; D007781:Lactoferrin / Q000096:biosynthesis; D008894:Milk Proteins / Q000096:biosynthesis / Q000235:genetics*; D008895:Milk, Human / Q000737:chemistry*; D030821:Plants, Genetically Modified / Q000378:metabolism*; D011994:Recombinant Proteins / Q000096:biosynthesis; D011198:Solanum tuberosum
chemical_list: D002364:Caseins; D008894:Milk Proteins; D011994:Recombinant Proteins; D007768:Lactalbumin; D007781:Lactoferrin