title: New developments in structure determination of pseudoknots.
abstract: Recently, several high-resolution structures of-RNA pseudoknots have become available. Here we review the progress in this area. The majority of the structures obtained belong to the classical or H-type pseudoknot family. The most complicated pseudoknot structure elucidated so far is the Hepatitis Delta Virus ribozyme, which forms a nested double pseudoknot. In particular, the structure-function relationships of the H-type pseudoknots involved in translational frameshifting have received much attention. All molecules considered show interesting new structural motifs.
authors.affiliation: NSR Center for Molecular Structure, Design and Synthesis, University of Nijmegen, The Netherlands. ceesh@sci.kun.nl
authors.forename: C W
authors.initials: CW
authors.lastname: Hilbers
authors.forename: P J
authors.initials: PJ
authors.lastname: Michiels
authors.forename: H A
authors.initials: HA
authors.lastname: Heus
mesh_terms: D001483:Base Sequence; D003698:Hepatitis Delta Virus / Q000235:genetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D016337:RNA, Catalytic / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D016337:RNA, Catalytic; D012313:RNA