Semisynthesis of 3-beta-hydroxyartemisinin
3-beta-Hydroxyartemisinin (5) was synthesized from 3-beta-hydroxydihydroartemisinic acid (7c) via singlet oxygen oxidation followed by air (triplet oxygen) oxidation. Compound 7c was synthesized in two steps from dihydroartemisinic acid, 7a.
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Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA.