title: Urinary pyridinoline and deoxypyridinoline as bone metabolic markers in predicting therapeutic effects of estrogen and alfacalcidol in women with osteoporosis.
abstract: The purpose of the present study was to evaluate the clinical usefulness of urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) in predicting therapeutic effects of estrogen and alfacalcidol (1alpha-D3) in patients with postmenopausal osteoporosis. We measured urinary excretion of Pyr and Dpyr, and determined bone mineral density (BMD) using a dual-energy x-ray absorptiometry in 48 women with osteoporosis (average age, 55.9+/-8.4 years). Patients were treated with estrogen (HRT, n = 13), 1alpha-D3 (n = 20), or calcium alone (n = 15). Baseline mean levels of urinary Pyr and Dpyr were significantly higher in the 48 patients compared to those in the age-matched postmenopausal women. The levels of urinary Pyr and Dpyr were inversely correlated with BMD. After treatment with estrogen or 1alpha-D3, a significant decrease of urinary Pyr and Dpyr was observed, and elevated urinary Pyr and Dpyr were reduced to the level in premenopausal women. A significant inverse correlation was found in Pyr and Dpyr at 6 months and in lumbar BMD after 24 months of treatment (r = -0.43 to -0.52; P < 0.01). We concluded that urinary Pyr and Dpyr have clinical utility for predicting response to estrogen and 1alpha-D3 therapy of osteoporosis patients.
authors.affiliation: Department of Endocrinology, Xiao Xi Tian No. 262 Hospital, Beijing, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhan
authors.forename: I
authors.initials: I
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Miura
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000596:Amino Acids / Q000652:urine*; D015415:Biomarkers / Q000652:urine; D015519:Bone Density / Q000187:drug effects; D001862:Bone Resorption; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000652:urine*; D011374:Progesterone / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D004967:Estrogens; D006887:Hydroxycholecalciferols; D011374:Progesterone; C015484:pyridinoline; C036020:deoxypyridinoline; C008088:alfacalcidol