Bioavailability of albendazole sulphoxide after netobimin administration in sheep: effects of fenbendazole coadministration.
After oral co-administration of two dosages of netobimin (7.5 and 20 mg kg-1 with fenbendazole (1.1 mg kg-1) to Merino sheep, the AUC0-infinity of albendazole sulphoxide at the lower dosage of netobimin, was significantly increased (75.5 per cent) from control value (34.43 +/- 7.91 versus 60.33 +/- 11.93 microg h ml-1). The pharmacokinetic parameters MRT and T1/2 were also increased: 18.96 +/- 2.54 vs 26.44 +/- 4.69 h and 10.31 +/- 1.72 vs 22.28 +/- 6.75 h respectively. No data corresponding to the higher dosage of netobimin (20 mg kg-1) were statistically different from control values. It is concluded that fenbendazole increases the bioavailability of albendazole sulphoxide in sheep at the 7.5 mg kg-1 dosage, and this may produce a potentiated anthelmintic action.
Merino
G
G
Laboratory of Animal Physiology. Faculty of Veterinary., University of León, León, E24071, Spain.
Alvarez
A I
AI
Redondo
P A
PA
Garcia
J L
JL
Larrodé
O M
OM
Prieto
J G
JG
D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000494:pharmacology*; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep
D000871:Anthelmintics; D006146:Guanidines; D005273:Fenbendazole; D015766:Albendazole; C027186:albendazole sulfoxide; C049626:netobimin