Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla.
Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.
Lee
J S
JS
College of Pharmacy, Seoul National University, Korea.
Yang
M Y
MY
Yeo
H
H
Kim
J
J
Lee
H S
HS
Ahn
J S
JS
D002455:Cell Division / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051966:Phospholipase C gamma; D019666:Rubiaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D007527:Isoenzymes; C120092:uncarinic acid A; D009828:Oleanolic Acid; D010738:Type C Phospholipases; D051966:Phospholipase C gamma