[Value of human colonic cancer models by surgical cecal implantation in nude mice].
A better understanding of the nature and treatment of colon cancer, and of by metastatic dissemination should be achieved by the use and study of appropriate animal models. Such models can be created by grafting human cancer cells or tumour fragments orthotopically into the colon or caecum of nude mice. This review examines the rationale behind these models and the principal results of orthotopic transplantation. Despite the fact that they require surgical expertise and are time-consuming, they provide valuable information on the mechanism of metastasis and the efficacy of novel treatments.
Pocard
M
M
ICRF-Colorectal Cancer Unit, Saint Mark's Hospital, Harrow, Middlesex, United Kingdom.
Middleton
S
S
Northover
J
J
Poupon
M F
MF
D000818:Animals; D002432:Cecum; D003110:Colonic Neoplasms / Q000473:pathology; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology