title: [Adenocarcinoma in Barrett's esophagus. A study of 28 resected cases].
abstract: OBJECTIVE
  The aim of this retrospective study was to report a series of 28 patients with adenocarcinoma (ADK) arising in Barrett's esophagus (BE), treated by esophagectomy.
  
  
  METHODS
  From 1992 to 1998, 28 patients were operated on for ADK in BE. There were 27 men and one woman (mean age: 65 years) classified as ASA I (n = 2), ASA II (n = 15) and ASA III (n = 11). Eighteen patients had a long story of gastro-esophageal reflux disease which required surgical repair in five of them. Dysphagia was the main symptom (n = 19). Surgical procedures included 15 Ivor Lewis operations, nine esophagectomies without thoracotomy and four esophagogastrectomies by the left thoracic approach.
  
  
  RESULTS
  Pathological examination of the specimens showed an EBO with adenocarcinoma (n = 27) and a high grade dysplasia (n = 1). Among five patients with a previously known BE, three under endoscopic surveillance had high grade dysplasia (n = 1) and limited T1 tumor (n = 2), while the other two patients without surveillance developed an invasive tumor (T3N1). There were three postoperative deaths (mortality rate: 10%), all arising from pulmonary failure. Median survival was 16.6 months. All patients resumed a normal diet. The actuarial survival rates were 63%, 42% and 15.2% respectively at 1, 2 and 4 years. A multivariate analysis could identify 3 prognostic factors: ASA score previously known BE under surveillance, length of BE.
  
  
  CONCLUSIONS
  Adenocarcinoma arising in BE is very often diagnosed too late. Patients with high risk BE require an endoscopic survey. High grade dysplasia detected in two successive examinations by two different pathologists may require prophylactic esophagectomy, but local endoscopic management presently under evaluation could be efficient in the future.
authors.affiliation: Service de chirurgie abdominale et thoracique, hôpital de l'Archet II, Nice, France.
authors.forename: D
authors.initials: D
authors.lastname: Benchimol
authors.forename: A
authors.initials: A
authors.lastname: Myx
authors.forename: J
authors.initials: J
authors.lastname: Mouroux
authors.forename: P
authors.initials: P
authors.lastname: Baqué
authors.forename: J L
authors.initials: JL
authors.lastname: Bernard
authors.forename: A
authors.initials: A
authors.lastname: Bourgeon
authors.forename: H
authors.initials: H
authors.lastname: Richelme
mesh_terms: D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000473:pathology* / Q000601:surgery; D002423:Cause of Death; D003680:Deglutition Disorders / Q000209:etiology; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013908:Thoracotomy; D013997:Time Factors