title: Apolipoprotein E polymorphism and the relationships of physical fitness to plasma lipoprotein-lipid levels in men and women.
abstract: OBJECTIVE
  A high level of cardiovascular fitness is generally associated with a plasma lipoprotein-lipid profile predictive of a low cardiovascular disease risk. We have investigated whether apolipoprotein (apo) E polymorphism could alter the relationships of physical fitness to plasma lipoprotein-lipid levels in a sample of healthy untrained subjects (64 premenopausal women and 65 men).
  
  
  METHODS
  Subjects were grouped according to gender and apo E phenotype determined by isoelectric focusing electrophoresis.
  
  
  RESULTS
  In both genders, VO2max expressed in mL x kg(-1) x min(-1) was negatively correlated with plasma triglyceride levels in apo E2 carriers and apo E3 homozygotes (-0.55< or =r< or =0.31; P<0.05), whereas these associations were not found in apo E4 groups. Plasma low-density lipoprotein (LDL)-C levels were negatively associated with VO2max (r = -0.39; P<0.05) only in women homozygotes for apo E3 whereas VO2max was positively correlated with plasma high-density lipoprotein (HDL)2-C levels only in men (r = 0.51; P<0.001) and women (r = 0.65; P<0.001) who were apo E3 homozygotes. A control for concomitant association with body fat mass and glucose intolerance performed by partial correlation analyses revealed that, with the exception of the plasma HDL2-C levels in the apo E3 homozygotes, most of the significant associations between VO2max (mL x kg(-1) x min(-1)) and plasma lipoprotein-lipid levels were mediated by concomitant variation in body fatness and glucose tolerance.
  
  
  CONCLUSIONS
  These results suggest that the magnitude of the relationships between VO2max and plasma lipoprotein-lipid levels is influenced by the apo E polymorphism. Thus, apo E2 carriers may be particularly responsive to improved fitness, thereby preventing the development of hypertriglyceridemia and type III dyslipoproteinemia.
authors.affiliation: Lipid Research Center, Physical Activity Sciences Laboratory, and Diabetes Research Unit, Laval University, Ste-Foy, Québec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: St-Amand
authors.forename: D
authors.initials: D
authors.lastname: Prud'homme
authors.forename: S
authors.initials: S
authors.lastname: Moorjani
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: A
authors.initials: A
authors.lastname: Tremblay
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: P J
authors.initials: PJ
authors.lastname: Lupien
authors.forename: J P
authors.initials: JP
authors.lastname: Després
mesh_terms: D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D001823:Body Composition; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D010809:Physical Fitness; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D008055:Lipids; D008074:Lipoproteins