Antifungal metabolites from the marine sponge Pachastrissa sp.: new bengamide and bengazole derivatives.
This paper reports the studies of components of an undescribed sponge in the genus Pachastrissa sp., collected along the Djibouti coast. The extract showed activity against Candida albicans. Six new bengazoles (1-6) and a new bengamide, named bengamide L (16), in addition to the known bengazoles (7-11), bengamides A (12), B (13), E (14), and F (15), and a lactone (17) are described in this paper. All structures were determined on the basis of spectroscopic studies.
Fernández
R
R
Laboratoire SESNAB, Pôle Science, Université de La Rochelle, 17042 La Rochelle Cedex 1, France.
Dherbomez
M
M
Letourneux
Y
Y
Nabil
M
M
Verbist
J F
JF
Biard
J F
JF
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000187:drug effects; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000302:isolation & purification / Q000494:pharmacology*; D011161:Porifera / Q000737:chemistry*
D000935:Antifungal Agents; D010080:Oxazoles