title: Combined use of steroid, antibiotics and early bougienage against stricture formation following caustic esophageal burns.
abstract: BACKGROUND
  If an esophageal burn is diagnosed, the aim is to prevent stricture formation. The combined use of steroid, antibiotics and early bougienage (SAEB) is one of the currently used treatment protocols. The effect of SAEB treatment against stricture formation following caustic esophageal burn has been evaluated retrospectively.
  
  
  METHODS
  Forty-nine children of 282 admitted with a history of caustic substance ingestion were found to have esophageal burns. Forty-nine children underwent treatment against stricture formation. SAEB was begun within 48 hours of ingestion.
  
  
  RESULTS
  Eight children of 12 who ingested sodium hydroxide and five children of 20 who ingested acids developed strictures in spite of the therapy. Additionally two esophageal perforations were encountered in patients who ingested sodium hydroxide.
  
  
  CONCLUSIONS
  This protocol has been found to carry a risk of perforation without preventing stricture formation after strong alkali ingestion. Therefore other treatment modalities for preventing strictures should be evaluated especially in children who have ingested products containing strong alkalis.
authors.affiliation: Department of Pediatric Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Karnak
authors.forename: F C
authors.initials: FC
authors.lastname: Tanyel
authors.forename: N
authors.initials: N
authors.lastname: Büyükpamukçu
authors.forename: A
authors.initials: A
authors.lastname: Hiçsönmez
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000628:therapy*; D002424:Caustics / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004939:Esophageal Perforation / Q000209:etiology; D004940:Esophageal Stenosis / Q000139:chemically induced* / Q000517:prevention & control*; D004947:Esophagus; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007440:Intubation; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use*; D012189:Retrospective Studies; D012972:Sodium Hydroxide / Q000009:adverse effects; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D002424:Caustics; D005938:Glucocorticoids; D012972:Sodium Hydroxide; D011239:Prednisolone