title: Nuclear receptor co-repressor gene localizes to 17p11.2, a frequently deleted band in malignant disorders.
abstract: The t(8;21) between the AML1 and ETO genes is a commonly seen genetic alteration in acute myeloid leukemia. Recently, we reported that the fusion partner ETO binds to the human nuclear receptor co-repressor (NCOR), a member of the NCOR/SIN3/histone deacetylase complex. This complex mediates transcriptional repression as a result of chromatin remodeling. Here, we used a combination of fluorescence in situ hybridization and hybrid panels to localize the human NCOR gene (NCOR) to chromosome band 17p11.2. The position of human NCOR on 17p11 raises the possibility of deranged transcriptional regulation in malignant disorders associated with deletions of 17p.
authors.affiliation: Center for Pediatric Research, Division of Medical Genetics, Children's Hospital of the King's Daughters and Eastern Virginia Medical School, Norfolk, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Stacey
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: R L
authors.initials: RL
authors.lastname: Byrd
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.forename: W G
authors.initials: WG
authors.lastname: Kearns
mesh_terms: D002872:Chromosome Deletion; D002874:Chromosome Mapping / Q000379:methods*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D056971:Nuclear Receptor Co-Repressor 1; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: C539127:NCOR1 protein, human; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D012097:Repressor Proteins