title: Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases.
abstract: A new class of protein kinase bisubstrate-analog inhibitors was designed on the basis of adenosine-5'-carboxylic acid derivatives, where a short peptide was attached to the 5'-carbon atom of the adenosine sugar moiety via a linker chain. The potency and selectivity of these inhibitors were adjusted by relevant combination of these structural fragments, resembling the structure of the bisubstrate complex of the peptide phosphorylation reaction.
authors.affiliation: Institute of Chemical Physics, Tartu University, Estonia.
authors.forename: M
authors.initials: M
authors.lastname: Loog
authors.forename: A
authors.initials: A
authors.lastname: Uri
authors.forename: G
authors.initials: G
authors.lastname: Raidaru
authors.forename: J
authors.initials: J
authors.lastname: Järv
authors.forename: P
authors.initials: P
authors.lastname: Ek
mesh_terms: D000241:Adenosine / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047428:Protein Kinase Inhibitors
chemical_list: D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D010455:Peptides; D047428:Protein Kinase Inhibitors; D000241:Adenosine