Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives.
Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.
Li
C
C
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA.
Lewis
M R
MR
Gilbert
A B
AB
Noel
M D
MD
Scoville
D H
DH
Allman
G W
GW
Savage
P B
PB
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D020355:Cholates / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011112:Polymyxin B / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D020355:Cholates; D011112:Polymyxin B