title: [Cerebral ischemia as initial manifestation of neoplastic low-malignancy changes. 2 case reports and review of the literatures].
abstract: Thrombembolic events as paraneoplastic complications in malignant disease account for severe morbidity and mortality in these patients. In some cases disturbance in hemostasis is the first manifestation of a neoplastic process. We report the cases of two patients with cerebral and extracerebral vessel occlusions, in whom epithelial tumors of low malignant potential (borderline-tumors) of ovary and peritoneum were diagnosed later on. In one case the removal of the tumor stopped the coagulation problems. The second patient died a few days after the first symptoms with devastating multiple vessel occlusion. In stroke of unknown aetiology a paraneoplastic process should be kept in mind. The diagnosis is more probable with recurrent thrombembolism in different body regions and when warfarin therapy was ineffective. Thoughtful coagulation studies and a tumor search program is recommended in these cases.
authors.affiliation: Neurologische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig-Maximilian-Universität München.
authors.forename: K
authors.initials: K
authors.lastname: Jahn
authors.forename: T
authors.initials: T
authors.lastname: Pfefferkorn
authors.forename: M
authors.initials: M
authors.lastname: Gropp
authors.forename: G
authors.initials: G
authors.lastname: Hamann
authors.forename: H W
authors.initials: HW
authors.lastname: Pfister
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018283:Cystadenocarcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003952:Diagnostic Imaging; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D009460:Neurologic Examination; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010053:Ovary / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery