Structural view of cadherin-mediated cell-cell adhesion.
Following the multiplication of biochemical, biophysical and structural studies describing cadherin molecules and their interactions, several ideas have emerged to explain the mechanisms of cadherin-mediated cell adhesion. Although different models were proposed for cadherin interactions, a consensus has come forth considering lateral dimerization of cadherins as being a central component of the cell-cell adhesion process. This review summarizes the recent development in structural studies of cadherin.
Alattia
J R
JR
Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada. mikura@oci.utoronto.ca
Kurokawa
H
H
Ikura
M
M
D015820:Cadherins / Q000737:chemistry* / Q000502:physiology; D002118:Calcium / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D019281:Dimerization; D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D013329:Structure-Activity Relationship; D015534:Trans-Activators; D051176:beta Catenin
C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D020033:Protein Isoforms; D015534:Trans-Activators; D051176:beta Catenin; D002118:Calcium