Vesicle formation from hexasubstituted cyclophosphazenic derivatives.
Hexakis[butoxytris(ethoxy)]cyclophosphazene (3a), hexakis[dodecyloxytetrakis (ethoxy)]cyclophosphazene (3b) and hexakis[hexadecyloxyeicosanekis(ethoxy)]cyclophosphazene+ ++ (3c) were synthesised and their ability to form niosomes was studied. All synthesised compounds in the presence of cholesterol were shown to form vesicles, which aggregated strongly. To prevent aggregation, dicetylphosphate was used. The capacity of the sonicated and unsonicated niosomes to encapsulate hydrophile and lipophile molecules was also studied using carboxyfluorescein and diphenylhexatriene.
Baroli
B
B
Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, Università di Cagliari, Via Ospedale 72, 09124, Cagliari, Italy.
Delogu
G
G
Fadda
A M
AM
Podda
G
G
Sinico
C
C
D002784:Cholesterol / Q000737:chemistry*; D008567:Membranes, Artificial; D008854:Microscopy, Electron; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013010:Sonication
D008567:Membranes, Artificial; D009943:Organophosphorus Compounds; D002784:Cholesterol