title: Effects of Fructus schizandrae on cycloheximide-induced amnesia in rats.
abstract: The effects of Fructus Schisandrae (Schizandra Chinensis, (FS) on cycloheximide (CXM)-induced amnesia by using a passive avoidance task were studied in rats. FS at 0.25 and 0.75 g/kg administered for 1 week significantly prolonged the CXM-shortened step-through latency (STL). Of the fractions (n-hexane, chloroform and water), only the water fraction at 25 mg/kg administered for 1 week prolonged the CXM-shortened STL. These results suggest that the water fraction is the main active fraction of FS.
authors.affiliation: Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, R.O.C.
authors.forename: M T
authors.initials: MT
authors.lastname: Hsieh
authors.forename: M L
authors.initials: ML
authors.lastname: Tsai
authors.forename: W H
authors.initials: WH
authors.lastname: Peng
authors.forename: C R
authors.initials: CR
authors.lastname: Wu
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning; D003513:Cycloheximide / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts; D003513:Cycloheximide