[Captopril combined with hydrochlorothiazide in mild and moderate hypertension. A Brazilian multicenter study].
OBJECTIVE
To evaluate the effectiveness and tolerance of the association of captopril 50 mg and hydrochlorithiazide 25 mg in hypertensive patients with diastolic pressure between 95 and 115 mmHg.


METHODS
An open, multicenter and non-comparative study was performed. After 2 weeks of placebo, the patients received 1/2 tablet of drug association. Patients were evaluated after 4, 8 and 12 weeks, and those who had diastolic pressure > 90 mmHg after 8 weeks of therapy received 1 tablet/day.


RESULTS
The results of 433 patients were analyzed: 47 +/- 10 years old, 30% female, 76% white. Initial systolic and diastolic pressures were 156 +/- 16 and 103 +/- 11 mmHg and after 14 days of placebo were 156 +/- 15 and 103 +/- 9 mmHg (p > 0.05). Systolic/diastolic pressure after 4, 8 and 12 weeks of treatment reduced progressively (p < 0.05) to 143 +/- 14/95 +/- 11, 140 +/- 13/91 +/- 9 and 134 +/- 11/86 +/- 8 mmHg. Blood pressure control was observed in 45, 67 and 88% (p < 0.05) of patients after 4, 8 and 12 weeks. Cough was the most important symptom, registered in 7% of patients under placebo and 12% in patients under treatment. The tolerance was considered good for 98% of patients.


CONCLUSIONS
The association of captopril with hydrochlorothiazide is effective with good tolerance, being indicated as a once a day monotherapy for mild and moderate hypertension.
Santello
J L
JL
Hospital das Clínicas da Faculdade de Medicina da USP.
Mion Júnior
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D002216:Captopril / Q000627:therapeutic use*; D004232:Diuretics; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004232:Diuretics; D004338:Drug Combinations; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D002216:Captopril