New MRI findings in Creutzfeldt-Jakob disease: high signal in the globus pallidus on T1-weighted images.
We report a 49-year-old woman with Creutzfeldt-Jakob disease (CJD). In addition to typical high-signal lesions on proton-density and T2-weighted images there was high signal in the globus pallidus bilaterally on T1-weighted images. The latter feature has not been described previously and probably due to deposition of prion protein, as found at autopsy.
de Priester
J A
JA
Department of Radiology, University Hospital Maastricht, The Netherlands.
Jansen
G H
GH
de Kruijk
J R
JR
Wilmink
J T
JT
D002421:Caudate Nucleus / Q000473:pathology; D003287:Contrast Media; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D019786:Gadolinium DTPA; D005917:Globus Pallidus / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011328:Prions / Q000032:analysis; D011699:Putamen / Q000473:pathology
D003287:Contrast Media; D011328:Prions; D019786:Gadolinium DTPA