title: Duocart biofiltration: a new method of hemodialysis.
abstract: DuoCart biofiltration (DCB) is a new hemodialysis method using a dialysate with only sodium chloride and bicarbonate obtained from two separate powder cartridges (BiCart and SelectCart, Gambro, Sweden). The ionic complement is directly reinfused in postdilution mode, using one 2 L bag of a specially designed sterile solution. The adaptation of the quantity of these infused substances to their removal through the dialysis membrane is made possible by repeated measurements of ionic dialysance (D), which are automatically performed every 30 min by the Diascan module, systematically available on the Integra dialysis monitor (Hospal, Italy), and by subsequent modification of the infusion rate (Q(R)). An appropriate kinetic model was used to determine the composition of the reinfusion solution (mM: 57 K, 47 Ca, 14.5 Mg, 180 Cl), the conductivity dialysate (set at 14.8 mS/cm) and the ratio Q(R)/D (set at 1/28). This ratio is kept constant by updating Q(R) after each measurement of D. The implementation of this technique requires an Integra dialysis monitor equipped with a two-powder-cartridge dialysate generation system. Fifteen dialysis sessions were performed (duration: 213+/-38 min; blood flow: 238+/-26 ml/min; ultrafiltration rate: 16+/-6 ml/min). The per-dialytic changes of ion plasma concentrations were monitored and found to be within the predicted range. The results substantiate the feasibility of this new hemodialysis method that presents several advantages: dialysate concentrates are in powder form, an alkaline and acetate-free dialysate is used with superior dialysate biocompatibility, no precipitation of Ca and Mg carbonate occurs in the dialysate circuit, the supply of calcium and potassium is easily adapted to individual patients' needs by change in the composition of the reinfusion solution, and a calcium-free dialysate that facilitates citrate anticoagulation is used.
authors.affiliation: Department of Nephrology, Hospital Pitié-Salpétrière, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Mercadal
authors.forename: T
authors.initials: T
authors.lastname: Petitclerc
authors.forename: B
authors.initials: B
authors.lastname: Béné
authors.forename: M C
authors.initials: MC
authors.lastname: Jaudon
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
mesh_terms: D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D015314:Dialysis Solutions; D017583:Hemodiafiltration / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007700:Kinetics; D016014:Linear Models; D008274:Magnesium / Q000097:blood; D008954:Models, Biological; D011188:Potassium / Q000097:blood / Q000493:pharmacokinetics; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D001639:Bicarbonates; D001786:Blood Glucose; D001798:Blood Proteins; D002712:Chlorides; D015314:Dialysis Solutions; D014508:Urea; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium