title: Congenital erythroleukemia in a neonate with severe hypoxic ischemic encephalopathy.
abstract: We report a case of a neonate who presented with hypoxic ischemic encephalopathy, persistent hypoglycemia and hypotension, intractable metabolic acidosis, renal failure and a coagulopathy but who, at autopsy, was found to have massive infiltration of nonhematopoietic tissues with blasts. The diagnosis of congenital erythroleukemia was confirmed by the detection of glycophorin A, a major erythrocyte membrane protein, on the surface of the blasts. The clinical presentation and course of the case described here have not previously been reported for this extremely rare condition.
authors.affiliation: Department of Pediatrics, Queen's University, Kingston, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Hadjiyannakis
authors.forename: W A
authors.initials: WA
authors.lastname: Fletcher
authors.forename: D P
authors.initials: DP
authors.lastname: Lebrun
authors.forename: R C
authors.initials: RC
authors.lastname: van Wylick
authors.forename: K E
authors.initials: KE
authors.lastname: Dow
mesh_terms: D001344:Autopsy; D002545:Brain Ischemia / Q000150:complications / Q000151:congenital* / Q000473:pathology / Q000628:therapy; D017809:Fatal Outcome; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications / Q000151:congenital* / Q000473:pathology / Q000628:therapy; D007231:Infant, Newborn; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications / Q000151:congenital* / Q000473:pathology / Q000628:therapy; D008297:Male; D009102:Multiple Organ Failure