[Effects of immunotherapy on cytokine production from peripheral blood mononuclear cells in patient with house dust mite allergic rhinitis].
We studied effects of immunotherapy on mite antigen-induced cytokine production from peripheral blood mononuclear cells in patient with house dust mite allergic rhinitis. In good response group, IL-4 production were lower than that of poor response group. In contrast, IFN-gamma production and the ratio of IFN-gamma to IL-4 synthesis were significant higher than that of poor response group. The production of IFN-gamma significantly correlated with the periods of immunotherapy. These results suggest that the changes of cytokine synthesis have a close relationship to clinical effects of immunotherapy.
Ishii
K
K
Department of Otolaryngology, Sapporo Medical University.
Asakura
K
K
Kataura
A
A
D000328:Adult; D000818:Animals; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008925:Mites / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000209:etiology / Q000276:immunology* / Q000628:therapy*
D015847:Interleukin-4; D007371:Interferon-gamma