title: Recent progress in biotechnology of Mexican medicinal plants.
abstract: Based on traditional medicinal knowledge, it was possible to identify the plant species Solanum chrysotrichum as the source of a new antimycotic agent designated SC-1. Cell suspension batch cultures from this plant were established in shake flasks, in which the production of SC-1 was optimized, reaching values fifty times higher than those registered in field grown plants. Large-scale cultivation of the active biomass from S. chrysotrichum was established in 10 l airlift bioreactors, and productivity levels of SC-1 were increased by 60% when using a draw-fill mode in the bioreactors.
authors.affiliation: Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social Argentina No 1, Xochitepec, Morelos, Mexico.
authors.forename: M L
authors.initials: ML
authors.lastname: Villarreal
authors.forename: P
authors.initials: P
authors.lastname: Nicasio
authors.forename: G
authors.initials: G
authors.lastname: Rojas
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: R
authors.initials: R
authors.lastname: Quintero
mesh_terms: D001709:Biotechnology; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008800:Mexico; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D012503:Saponins