Acute myeloblastic leukemia (M0) with an unusual chromosomal abnormality: translocation (1;14)(p13;q32).
We describe a case of acute myeloblastic leukemia, French-American-British subclassification of M0 (AML-M0), with an unusual chromosomal abnormality. The diagnosis of AML-M0 was made morphologically, cytochemically, and immunophenotypically. At the time of diagnosis, cytogenetic studies were performed, revealing a translocation involving chromosomes 1 and 14--specifically t(1;14)(p13;q32). The patient responded to high-dose ARA-C. In our survey of the literature, we were unable to find a reported case of AML-M0 with this chromosomal translocation.
Tecimer
C
C
Department of Hematology/Medical Oncology, University of Louisville School of Medicine, Kentucky, USA.
Loy
B A
BA
Martin
A W
AW
D015703:Antigens, CD / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism; D014178:Translocation, Genetic
D015703:Antigens, CD; D006684:HLA-DR Antigens; D003561:Cytarabine; D009195:Peroxidase; D015255:Idarubicin