title: [Low-dose estrogens in the treatment of the climacteric syndrome].
abstract: The present prospective study is aimed to estimate the effect of a low-dose combined oestrogen drug Cyclo-Menorette on climacteric syndrome in women with early menopause.
  
  
  METHODS
  The criteria for inclusion in the study were ac follows: 9-12 months of menopause, increased FSH levels, moderately expressed climacteric syndrome confirmed by the menopausal index of Kupperman and Hamilton-Anxiety-Scale /HAMA/. According to acceptance of hormone replacement therapy /HRT/ the women were divided into 2 groups--control T /n = 31/ and Cunder treatment T /n = 35/. The degree of climacteric syndrome expression after Kupperman and HAMA was estimated in all patients at the beginning as well as on the 3-d, 6-th 12-d months. The presence and dynamics of side effects were followed in the patients treated with HRT.
  
  
  RESULTS
  Spontaneous improvement of complaints was found out in the control group with an increase of intragroup differences during the follow-up period. Most expressed improvement in the group under treatment was established during the first 3-6 months, the beneficial effect being preserved until the end of the study.
  
  
  CONCLUSIONS
  The use of 1 mg oestradiol valerat in combination with 2 mg oestriol results in a significant decrease of climacteric syndrome manifestation with slightly expressed and transient side effects.
authors.forename: G
authors.initials: G
authors.lastname: Kolarov
authors.forename: B
authors.initials: B
authors.lastname: Nalbanski
authors.forename: Z
authors.initials: Z
authors.lastname: Kamenov
authors.forename: M
authors.initials: M
authors.lastname: Protich
authors.forename: M
authors.initials: M
authors.lastname: Obretsova
authors.forename: M
authors.initials: M
authors.lastname: Sirakov
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D045166:Estradiol Congeners / Q000008:administration & dosage* / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D013577:Syndrome; D013997:Time Factors
chemical_list: D045166:Estradiol Congeners