title: [Hemostatic effect of a novel sheeted fibrin adhesive agent, TO-193, on experimental incision models].
abstract: TO-193 (TachoComb) is a new fibrin adhesive agent that consists of a collagen sheet coated with fibrin glue. We compared the hemostatic effect of TO-193 in several experimental models with Beriplast P as a fibrin adhesive agent, Avitene and Novacol as a microfibrillar collagen hemostat, and a sponge-like collagen sheet as the constitutional parts of TO-193. In the in vitro bleeding model in which blood leaks out through cotton cloth, the pressure of TO-193 when blood leakage was observed was higher than those of Beriplast P, Avitene, Novacol and the collagen sheet, indicating that TO-193 possessed a strong adhesive effect on the bleeding surface. On the kidney resection surface, TO-193 showed a more potent adhesive effect than those of Beriplast P and the collagen sheet, suggesting that TO-193 has a potent hemostatic effect. In the liver resection, TO-193 significantly reduced the bleeding volume compared with that of Novacol in normal rats. Furthermore, the bleeding volume of TO-193 was about half that of Beriplast P and equivalent to that of Novacol even in anticoagulant-treated rats. From these data, it is expected that TO-193 would be a valuable hemostatic agent for clinical use since TO-193 possesses a potent adhesive ability on the bleeding resection surface and would certainly stop bleeding in both patients with normal coagulation and those with a low blood coagulation condition.
authors.affiliation: Research Laboratories, Torii Pharmaceutical Co., Ltd., Chiba, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Maekawa
authors.forename: H
authors.initials: H
authors.lastname: Ohtani
authors.forename: H
authors.initials: H
authors.lastname: Uchiyama
authors.forename: S
authors.initials: S
authors.lastname: Kashiwabara
authors.forename: Y
authors.initials: Y
authors.lastname: Koshiyama
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Kurumi
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D007611:Aprotinin / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use*; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000627:therapeutic use*; D006493:Heparin / Q000494:pharmacology; D006498:Hepatectomy; D066298:In Vitro Techniques; D008297:Male; D009392:Nephrectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use; D014859:Warfarin / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D014014:Tissue Adhesives; C093991:tachocomb; D014859:Warfarin; D005340:Fibrinogen; D006493:Heparin; D003094:Collagen; D007611:Aprotinin; D013917:Thrombin