title: Regulation and characterization of the Na+/H+ exchanger.
abstract: The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity.
authors.affiliation: Department of Biochemistry, University of Alberta, Edmonton, Canada. lfliegel@gpu.srv.ualberta.ca
authors.forename: L
authors.initials: L
authors.lastname: Fliegel
authors.forename: R
authors.initials: R
authors.lastname: Murtazina
authors.forename: P
authors.initials: P
authors.lastname: Dibrov
authors.forename: C
authors.initials: C
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Moor
authors.forename: F A
authors.initials: FA
authors.lastname: Fernandez-Rachubinski
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D011817:Rabbits; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000737:chemistry* / Q000502:physiology*
chemical_list: D017923:Sodium-Hydrogen Exchangers