title: Uncarinic acids: phospholipase Cgamma1 inhibitors from hooks of Uncaria rhynchophylla.
abstract: Bioactivity-guided fractionation of the CHCl3 extract from hooks of Uncaria rhynchophylla led to the isolation of two triterpene esters, namely uncarinic acids A (1) and B (2). Their structures were established by spectroscopic and chemical methods. These compounds inhibited phospholipase Cgamma1 with IC50 values of 35.66 and 44.55 microM, respectively.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: M Y
authors.initials: MY
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Yeo
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D002455:Cell Division / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051966:Phospholipase C gamma; D019666:Rubiaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; C120092:uncarinic acid A; D009828:Oleanolic Acid; D010738:Type C Phospholipases; D051966:Phospholipase C gamma