[Evaluation of two methods to avoid the nephropathy associated with radiologic contrast].
Our objective was to establish the efficacy of two methods to avoid contrast associated nephropathy (C.A.N). We studied in prospective and randomized form a sample of 75 patients of whom 25 were assigned to the


METHODS
without interventions; 25 to the Saline group: 0.45% saline solution I.V., 1.5 cc/kg/min, 6 hours before and after the angiographic study and 25 to the Dopa group: equal procedure plus the aggregate of dopamine 2 micrograms/kg/min, 30 minutes before the study until the termination. The evaluation effected at patient's entry was considered T0, T1, 24 hs after the T2, 48 hs after. In T0 was registered: age, sex, pathological antecedents, drugs and plasmatic creatinine, and in T2 creatinine. An increase of 25% of the plasmatic creatinine in T2 was considered as C.A.N. The latter was present in 13/25 (OR: 1) CONTROL GROUP patients, 7/25 (OR 0.36), Salina group patients and in 5/25 (OR 0.23) Dopa group patients (p = 0.01). No significant difference was registered in the urinary output nor in the plasmatic creatinine levels. It is concluded that hydration during six hours before and after the study with 0.45% saline solution and the same plan with the aggregate of dopamine are effective to prevent a C.A.N.
Diez
T
T
Servicio de Clínica Médica, Sanatorio Delta, Rosario, Argentina.
Bagilet
D
D
Ramos
M
M
Jolly
H
H
Diab
M
M
Marcucci
R
R
Rojo
L
L
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000032:analysis; D004298:Dopamine / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D018709:Statistics, Nonparametric
D003287:Contrast Media; D012462:Saline Solution, Hypertonic; D003404:Creatinine; D004298:Dopamine