Regional specialization in the mucosal immune system: primed cells do not always home along the same track.
According to the current paradigm of lymphocyte trafficking, primed B and T cells extravasate in the intestinal lamina propria chiefly by means of the mucosal homing receptor alpha4beta7, which interacts with the vascular addressin MAdCAM-1. However, as discussed here, this mechanism cannot explain the preferential homing of B cells with a high level of J-chain expression to mucosal effector sites outside the gut.
Brandtzaeg
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P
Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, N-0027 Oslo, Norway. per.brandtzaeg@labmed.uio.no
Farstad
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IN
Haraldsen
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015815:Cell Adhesion Molecules; D002465:Cell Movement / Q000276:immunology; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D018928:Immunity, Mucosal / Q000276:immunology*; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000378:metabolism; D007144:Immunoglobulin J-Chains / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology; D009088:Mucoproteins / Q000378:metabolism; D010641:Phenotype; D016201:Receptors, Lymphocyte Homing / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D015815:Cell Adhesion Molecules; D007070:Immunoglobulin A; D007144:Immunoglobulin J-Chains; D007136:Immunoglobulins; D016023:Integrins; C504265:MADCAM1 protein, human; D009088:Mucoproteins; D016201:Receptors, Lymphocyte Homing