title: Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus.
abstract: Two new triterpene caffeates have been isolated from the root bark of Hibiscus syriacus. Their structures were established through various spectral studies as 3beta,23,28-trihydroxy-12-oleanene 23-caffeate (1) and 3beta,23,28-trihydroxy-12-oleanene 3beta-caffeate (2). Compounds 1 and 2 showed lipid peroxidation inhibitory activity and significant cytotoxicity against a panel of human cancer cell lines.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Yun
authors.forename: I J
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: I K
authors.initials: IK
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Park
authors.forename: D H
authors.initials: DH
authors.lastname: Choung
authors.forename: K H
authors.initials: KH
authors.lastname: Han
authors.forename: I D
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019660:Malvaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: C120212:3,23,28-trihydroxy-12-oleanene 23-caffeate; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D014315:Triterpenes