Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin.
The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.
Doit
C
C
Laboratoire de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
Loukil
C
C
Fitoussi
F
F
Geslin
P
P
Bingen
E
E
D000658:Amoxicillin / Q000494:pharmacology*; D016172:DNA Fingerprinting; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D012150:Polymorphism, Restriction Fragment Length; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics
D010406:Penicillins; D000658:Amoxicillin