Primary biliary cirrhosis associated with painless thyroiditis.
A case of anti-mitochondrial antibody (AMA)-negative primary biliary cirrhosis (PBC) associated with painless thyroiditis is reported in a 47-year-old woman who diagnosed as PBC based on her elevated serum gamma-glutamyl transpeptidase and immunoglobulin M levels, as well as histological findings of destroyed bile ducts surrounded by mononuclear infiltrates in the biopsied liver. She was negative for AMA and had a depressed level of thyroid-stimulating hormone accompanied by increased free thyrosine, thyroxine and triiodothyronine levels and low titers of anti-microsomal and anti-thyroid peroxidase antibodies. Her thyroid disorder corresponded with painless thyroiditis. An association between PBC and hyperthyroidism is rare. Furthermore, an association between AMA-negative PBC and hyperthyroidism due to painless thyroiditis has not previously been reported.
Sato
N
N
Department of Internal Medicine II, Fukushima Medical University School of Medicine.
Ohira
H
H
Orikasa
H
H
Shinzawa
J
J
Suzuki
T
T
Tojo
J
J
Miyata
M
M
Nishimaki
T
T
Kasukawa
R
R
D001323:Autoantibodies / Q000276:immunology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications / Q000276:immunology; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000097:blood; D007453:Iodide Peroxidase / Q000276:immunology; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications* / Q000276:immunology; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology; D010146:Pain / Q000150:complications; D013963:Thyroid Hormones / Q000097:blood; D013966:Thyroiditis / Q000097:blood / Q000150:complications* / Q000276:immunology; D005723:gamma-Glutamyltransferase / Q000097:blood
D001323:Autoantibodies; D007075:Immunoglobulin M; D013963:Thyroid Hormones; D007453:Iodide Peroxidase; D005723:gamma-Glutamyltransferase