The role of SHIP in growth factor induced signalling.
The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5' phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more widely expressed counterpart, SHIP2, could play a central role in determining PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo function of SHIP further we recently generated a SHIP knock out mouse and in this review we discuss experiments carried out with bone marrow derived mast cells (BMMCs) from these animals.
Huber
M
M
Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada.
Helgason
C D
CD
Damen
J E
JE
Scheid
M
M
Duronio
V
V
Liu
L
L
Ware
M D
MD
Humphries
R K
RK
Krystal
G
G
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008407:Mast Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010716:Phosphatidylinositols / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D015398:Signal Transduction; D018909:src Homology Domains
D006133:Growth Substances; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases