title: Carboxylic acid microbial metabolites of the natural benzoquinone, maesanin
abstract: Maesanin (1) is a naturally occurring bioactive benzoquinone isolated from the fruits of Maesa lanceolata (Myrsinaceae). Three carboxylic acid metabolites of maesanin were isolated in the course of a prospective microbial transformation study. The first metabolite, 2, was produced by Lipomyces lipofer ATCC 10742 and was characterized as (Z)-15-(2'-hydroxy-5'-methoxy-3', 6'-dioxocyclohexa-1',4'-dienyl)pentadec-5-enoic acid. Metabolites 3 and 4 were produced by Rhodotorula rubra ATCC 20129 and were characterized as 6-(2'-hydroxy-5'-methoxy-3',6'-dioxocyclohexa-1', 4'-dienyl)hexanoic acid and 4-(2'-hydroxy-5'-methoxy-3', 6'-dioxocyclohexa-1',4'-dienyl)butanoic acid, respectively.
authors.affiliation: Department of Pharmacognosy and National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, and Department of Pharmacog.
authors.initials: EA
authors.lastname: Abourashed
authors.initials: FS
authors.lastname: El-Feraly
authors.initials: CD
authors.lastname: Hufford