title: Cytoskeletal rearrangement during migration and activation of T lymphocytes.
abstract: T lymphocytes have an inherent ability to migrate along a chemotactic gradient, which enables them to exit the bloodstream and reach different tissues. Motile T cells display a polarized morphology with two distinct cell compartments: the leading edge and the uropod. During cell polarization, chemoattractant receptors, cell-adhesion molecules and cytoskeletal proteins are redistributed within these cellular compartments. The polarity of T lymphocytes changes during the establishment of antigen-specific cell-cell interactions, and this involves rearrangement of cytoskeletal proteins. This article discusses the regulation of these cytoskeletal rearrangements, and their role in the activation, migration and effector function of T cells.
authors.affiliation: Servico de Immunolog a, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Serrador
authors.forename: M
authors.initials: M
authors.lastname: Nieto
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Madrid
mesh_terms: D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism
chemical_list: D011948:Receptors, Antigen, T-Cell