title: Induction of neutralizing autoantibodies to interferon-gamma in patients with polyneuropathy.
abstract: We previously demonstrated the induction of IFN-gamma in polyneuropathy patients associated with monoclonal gammopathy, but not in patients with presumably non-immunological types of neuropathy. We herein examined mechanism involving release of neutralizing autoantibodies (Aabs) to IFN-gamma in sera from those patients. In contrast to polyneuropathy patients with monoclonal gammopathy, patients with polyneuropathy of presumably non-immunological types showed increased production of neutralizing Aabs specific for IFN-gamma. These results demonstrate a role for autoimmunity in cytokine regulation. However, their association to the clinical manifestations of the disease requires further investigations, which are necessary for future consideration in therapeutic strategies.
authors.affiliation: Division of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: R A
authors.initials: RA
authors.lastname: Elkarim
authors.forename: M
authors.initials: M
authors.lastname: Mustafa
authors.forename: H
authors.initials: H
authors.lastname: Link
authors.forename: M
authors.initials: M
authors.lastname: Bakhiet
authors.forename: C
authors.initials: C
authors.lastname: Ekerfelt
authors.forename: M
authors.initials: M
authors.lastname: Vrethem
authors.forename: J
authors.initials: J
authors.lastname: Ernerudh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000276:immunology*; D009500:Neutralization Tests; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007371:Interferon-gamma