title: Tumour necrosis factor alfa and glucose levels in sera of mice infected with coxsackie B4 and A7 viruses.
abstract: Cytokines have been suggested to play an important role in the pathogenesis of type I diabetes mellitus through their direct and indirect effects on the pancreatic islet cells. We studied the time course of tumour necrosis factor alpha (TNF-alpha) and glucose levels in the sera of mice infected with coxsackie B4 and A7 viruses. Two correlating peaks of TNF-alpha and glucose were found. These results suggest the involvement of TNF-alpha in the damage of the insulin producing cells and thus an immunity-related inflammatory process.
authors.affiliation: Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
authors.forename: S A
authors.initials: SA
authors.lastname: Bopegamage
authors.forename: A
authors.initials: A
authors.lastname: Petrovicová
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D029822:Enterovirus B, Human; D008297:Male; D051379:Mice; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha