Immunologic parameters as predictive factors of cytomegalovirus disease in renal allograft recipients.
Cytomegalovirus (CMV) disease is a major problem in renal transplant recipients, but few predictive markers of the disease are known. Several immunologic parameters of potential relevance for the defense against CMV were measured after renal transplantation in 25 patients before any manifestations of CMV infection occurred. In 10 patients who later developed CMV disease, plasma levels of interleukin-8 were significantly higher, whereas the levels of macrophage inflammatory protein-1alpha (MIP-1alpha) were significantly lower than in 15 patients who did not develop CMV disease. Also, lower numbers of CD4+ and CD8+ lymphocytes were observed in patients who later had CMV disease. These findings were independent of previous rejection therapy and were particularly pronounced in patients with primary CMV infection. Interleukin-8 and MIP-1alpha may be predictive markers of CMV disease and could be of potential use in selecting patients for prophylactic treatment.
Nordøy
I
I
Section of Clinical Immunology and Infectious Diseases, Research Institute for Internal Medicine, Medical Dept. A, Rikshospitalet, N-0027 Oslo, Norway. ingvild.nordoy@klinmed.uio.no
Müller
F
F
Nordal
K P
KP
Rollag
H
H
Lien
E
E
Aukrust
P
P
Frøland
S S
SS
D000328:Adult; D000368:Aged; D015984:Causality; D015815:Cell Adhesion Molecules / Q000097:blood; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis; D016176:T-Lymphocyte Subsets; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015815:Cell Adhesion Molecules; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10