Cytoskeletal rearrangement during migration and activation of T lymphocytes.
T lymphocytes have an inherent ability to migrate along a chemotactic gradient, which enables them to exit the bloodstream and reach different tissues. Motile T cells display a polarized morphology with two distinct cell compartments: the leading edge and the uropod. During cell polarization, chemoattractant receptors, cell-adhesion molecules and cytoskeletal proteins are redistributed within these cellular compartments. The polarity of T lymphocytes changes during the establishment of antigen-specific cell-cell interactions, and this involves rearrangement of cytoskeletal proteins. This article discusses the regulation of these cytoskeletal rearrangements, and their role in the activation, migration and effector function of T cells.
Serrador
J M
JM
Servico de Immunolog a, Hospital de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Nieto
M
M
Sánchez-Madrid
F
F
D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism* / Q000502:physiology*; D008213:Lymphocyte Activation / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell