title: Inhibition of human telomerase by PNA-cationic peptide conjugates.
abstract: The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
authors.affiliation: Department of Chemistry, University of Cambridge, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Harrison
authors.forename: C
authors.initials: C
authors.lastname: Frier
authors.forename: R
authors.initials: R
authors.lastname: Laurant
authors.forename: R
authors.initials: R
authors.lastname: Dennis
authors.forename: K D
authors.initials: KD
authors.lastname: Raney
authors.forename: S
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D002412:Cations / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D008957:Models, Genetic; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000037:antagonists & inhibitors*; D013696:Temperature
chemical_list: D002412:Cations; D020135:Peptide Nucleic Acids; D019098:Telomerase