title: Families of arsenic transporters.
abstract: Bacterial arsenic resistance (ars) operons encode an arsenite-efflux system that can be a secondary carrier protein (ArsB) or an anion-translocating ATPase (ArsAB). Yeasts extrude arsenite using Acr3p, a plasma membrane carrier protein, or sequester it in vacuoles as the glutathione conjugate using Ycf1p, an ABC transporter.
authors.affiliation: Dept of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI 48201, USA. brosen@med.wayne.edu
authors.forename: B P
authors.initials: BP
authors.lastname: Rosen
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D053502:Arsenate Reductases; D001152:Arsenicals / Q000378:metabolism* / Q000494:pharmacology; D053501:Arsenite Transporting ATPases; D001419:Bacteria / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism; D005798:Genes, Bacterial; D016623:Ion Pumps; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009097:Multienzyme Complexes; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014617:Vacuoles / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D000251:Adenosine Triphosphatases; D053502:Arsenate Reductases; D001152:Arsenicals; D053501:Arsenite Transporting ATPases; D002352:Carrier Proteins; D005656:Fungal Proteins; D016623:Ion Pumps; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009097:Multienzyme Complexes; D029701:Saccharomyces cerevisiae Proteins; C109281:ACR3 protein, S cerevisiae; C089179:YCF1 protein, S cerevisiae; C506971:ARR2 protein, S cerevisiae