title: Sleep-disordered breathing and periodic limb movements in sleep in older patients with schizophrenia.
abstract: BACKGROUND
  Since the prevalence of both sleep-disordered breathing (SDB) and periodic limb movements in sleep (PLMS) increase with age, we explored whether older schizophrenia patients would have a high incidence of SDB and PLMS. Correlations between sleep and clinical variables were also examined.
  
  
  METHODS
  Fifty-two patients (mean age = 59.6 years, SD = 8.9) had their sleep/wake, respiration, and leg movements recorded using a modified Medilog/Respitrace portable recording system plus oximetry. A battery of clinical, psychosocial, and motor disturbance variables were collected by research center staff.
  
  
  RESULTS
  Forty-eight percent of these patients had at least 10 respiratory events per hour of sleep. These patients reported more symptoms of daytime sleepiness than patients with fewer than 10 events per hour. The relatively high prevalence of SDB in this group may contribute to overall sleep disturbances, and does not appear to be a result of high body mass index. Only 14% of the patients had at least five limb movements per hour of sleep, suggesting the prevalence of PLMS is much lower than expected in this age group. The number of leg jerks was inversely related to symptoms of tardive dyskinesia.
  
  
  CONCLUSIONS
  The disturbance of sleep in these patients may be due, in part, to SDB, but is unlikely due to PLMS.
authors.affiliation: Department of Psychiatry, University of California, San Diego, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: D W
authors.initials: DW
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Caligiuri
authors.forename: T
authors.initials: T
authors.lastname: Patterson
authors.forename: M J
authors.initials: MJ
authors.lastname: Harris
authors.forename: D V
authors.initials: DV
authors.lastname: Jeste
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology; D014150:Antipsychotic Agents / Q000009:adverse effects; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000150:complications* / Q000503:physiopathology; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000150:complications*; D012893:Sleep Wake Disorders / Q000139:chemically induced / Q000150:complications*; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents