Role of lysosomes on human ulcerogenic gastropathies. Effect of zinc ion on the lysosomal stability.
Numerous conditions are involved in the equilibrium between protective and aggressive factors for gastric mucosa injuring. Among them the lysosomal membrane stability plays a very important role in the inflammatory process. Zinc ion is a well-known lysosomal membrane stabilizer. When given orally to animals or even to humans it protects gastric mucosa against erosive lesions induced by a variety of experimental conditions. Compared with the control group (8.45 +/- 1.49 mU/mg) the lysosomes isolated from samples of gastric mucosa obtained from patients suffering of erosive gastropathies, showed a great liability on their membranes (18.37 +/- 4.52 mU/mg). When these patients were treated orally with zinc sulfate (100 mg of zinc element, twice a day, for two weeks) the lysosomes isolated from their gastric mucosa showed a strong reduction on enzymatic activity (5.49 +/- 1.02 mU/mg), probably due to increasing on the membrane stability. Based on these experimental findings we propose the use of zinc ion as an important adjuvant in treatment of erosive gastropathies.
Rodrigues
L E
LE
Biochemistry Department, Instituto de Ciências da Saúde, Federal University of Bahia, Salvador, Brazil.
Paes
I B
IB
Jacobina
H
H
D000135:Acid Phosphatase / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D005773:Gastroscopy; D006801:Humans; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*; D015032:Zinc / Q000494:pharmacology* / Q000627:therapeutic use
D000135:Acid Phosphatase; D015032:Zinc