title: MRI findings of isolated beta-2 microglobulin amyloidosis presenting as a cervical spine mass. Case report and review of literature.
abstract: A patient without prior history of renal failure or hemodialysis presented with weakness of the extremities. On magnetic resonance imaging (MRI), a peri-odontoid soft-tissue mass hypointense to muscle on both T1- and T2-weighted images was noted without obvious bony destruction. Pathological examination revealed degenerated fibrocartilage which stained for amyloid. Further, peroxidase staining for beta-2 microglobulin was positive. We describe the first case of a beta-2 microglobulin peri-odontoid amyloidoma without preceding history of hemodialysis and a review of literature is performed.
authors.affiliation: Department of Radiology, Medical College of Ohio, Toledo 43614-2598, USA.
authors.forename: G
authors.initials: G
authors.lastname: Moonis
authors.forename: E R
authors.initials: ER
authors.lastname: Savolaine
authors.forename: S A
authors.initials: SA
authors.lastname: Anvar
authors.forename: A
authors.initials: A
authors.lastname: Khan
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000175:diagnosis*; D002356:Cartilage / Q000737:chemistry / Q000473:pathology; D002574:Cervical Vertebrae / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D013122:Spinal Diseases / Q000175:diagnosis*; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D001613:beta 2-Microglobulin