title: Oral cyclosporine decreases severity of neurotoxicity in liver transplant recipients.
abstract: Neoral is a new formulation of cyclosporine that permits reliable absorption in patients with external biliary drainage. The authors reviewed 227 liver transplant patients receiving primary treatment with Neoral. Headache occurred in 24 patients (11%), mild tremors in 12 patients, paresthesia in 5 patients, acute confusional state in 4 patients, and seizures in 2 patients. It is apparent that Neoral has profoundly reduced the severity of neurotoxicity in liver transplant recipients.
authors.affiliation: Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Wijdicks
authors.forename: L J
authors.initials: LJ
authors.lastname: Dahlke
authors.forename: R H
authors.initials: RH
authors.lastname: Wiesner
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000503:physiopathology*
chemical_list: D016572:Cyclosporine