title: [A survival case of fulminant pneumococcal meningitis as overwhelming postsplenectomy infection (OPSI) syndrome].
abstract: A 39-year-old female, who had splenectomy for idiopathic thrombocytopenic purpura (ITP) in 1988, was admitted to our hospital with high fever, headache, and loss of consciousness on November 29,1997. Neck stiffness and Kernig's sign were present. Examination of cerebrospinal fluid showed pleocytosis up to 506 cells/mm3 with 89% of polymorphonuclear cells and elevated protein to 1,135 mg/dl, and absence of glucose, Streptococcus pneumoniae phagocytosis was detected in the fluid. We diagnosed her as having pneumococcal meningitis as overwhelming postsplenectomy infection (OPSI) syndrome. After administration of dexamethasone (8 mg/day), cefotaxime (4 g/day), and ampicillin (6 g/day), she survived without any complications. Splenectomized patients have been recognized as immunocompromized hosts, and carry high morbidity and mortality risk from fulminant bacterial infections. Therefore, emergency treatment is important to reduce high mortality in such infections. We present an adult case of OPSI syndrome which occurred as pneumococcal meningitis, and we would like to emphasize the importance of prompt use of corticosteroids and high dose of sensitive antibiotics before DIC may occur during the course of illness.
authors.affiliation: Department of Neurology, National Saishunso Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Imamura
authors.forename: H
authors.initials: H
authors.lastname: Teramoto
authors.forename: M
authors.initials: M
authors.lastname: Uchino
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002439:Cefotaxime / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D010406:Penicillins / Q000008:administration & dosage; D011183:Postoperative Complications / Q000188:drug therapy*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery; D013156:Splenectomy; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D002511:Cephalosporins; D010406:Penicillins; D000667:Ampicillin; D003907:Dexamethasone; D002439:Cefotaxime