Acyl-CoA: cholesterol acyltransferase inhibitory activity of ginseng sapogenins, produced from the ginseng saponins.
Ginseng sapogenins were produced from ginseng saponins, isolated from Korean ginseng roots. Ginseng saponins very mildly inhibited acyl-CoA:cholesterol acyltransferase (ACAT) in vitro, however, the sapogenins showed strong inhibitory activity on microsomal ACAT. Therefore, the sapogenins will be one of key ingredients of ginseng affected a lowering of the serum total cholesterol level.
Kwon
B M
BM
Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon.
Kim
M K
MK
Baek
N I
NI
Kim
D S
DS
Park
J D
JD
Kim
Y K
YK
Lee
H K
HK
Kim
S I
SI
D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D051381:Rats; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012503:Saponins / Q000737:chemistry*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D000924:Anticholesteremic Agents; D004791:Enzyme Inhibitors; D012502:Sapogenins; D012503:Saponins; D002785:Sterol O-Acyltransferase