title: Fat emulsion administration in the early postoperative period in patients undergoing esophagectomy for carcinoma depresses arachidonic acid metabolism in neutrophils.
abstract: The aim of this study was to evaluate the effect of fat emulsion administration on neutrophil arachidonic acid and leukotriene B4 (LTB4) generation in surgically stressed patients. Total parenteral nutrition was administered to 17 patients for 2 wk after esophagectomy for carcinoma. Eight patients received fat with glucose (fat group, 30% of total calories) and 9 patients received glucose (glucose group) as a non-protein calorie source from the day of the operation to the seventh postoperative day (POD), and they gradually were converted to enteral nutrition during the second postoperative week. The arachidonic acid in the fat group decreased in the serum from POD 4 to 14. and in neutrophils from 12 h after the beginning of surgery to POD 14, compared to preoperative levels. LTB4 production by A23187-stimulated neutrophils was highest 6 h after the beginning of surgery, when neutrophil arachidonic acid concentration was decreasing, and then fell below the preoperative value from POD 4 to 14 in both groups. LTB4 production on POD 14 was lower in the fat group than in the glucose group. Biosynthesis of arachidonic acid from linoleic acid is inhibited in surgically stressed patients receiving fat emulsion, resulting in the diminished synthesis of LTB4 by neutrophils. The decrease in LTB4 may diminish chemotactic and chemokinetic signals to other leukocytes.
authors.affiliation: First Department of Surgery, Kagoshima University School of Medicine, Kagoshima City, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sane
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: C
authors.initials: C
authors.lastname: Kusano
authors.forename: K
authors.initials: K
authors.lastname: Shirao
authors.forename: T
authors.initials: T
authors.lastname: Kamada
authors.forename: T
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000368:Aged; D016718:Arachidonic Acid / Q000097:blood*; D000001:Calcimycin / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage*; D004655:Emulsions; D004750:Enteral Nutrition; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007975:Leukotriene B4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011184:Postoperative Period
chemical_list: D004041:Dietary Fats; D004655:Emulsions; D005227:Fatty Acids; D007975:Leukotriene B4; D016718:Arachidonic Acid; D000001:Calcimycin; D005947:Glucose