title: [Man-made vitreous fibers: current state of knowledge].
abstract: Artificial vitreous fibres have been used as thermal insulation since the 1930's. Experimental studies on possible pathogenic, fibrogenic or carcinogenic effects did not produce any clear results until the 1970's, when Stanton demonstrated the carcinogenic effect of these and numerous other fibrous materials after direct inoculation in the pleural cavity. In subsequent years epidemiological and experimental studies multiplied: the epidemiological investigations did not show any evident pathogenic effects on very large cohorts of workers, and experimentally the carcinogenic effect was confirmed only by inoculation of high doses of fibres, while negative results were reported in inhalatory experiments. In view of the considerably long time that has elapsed since these materials were first used, the low biopersistence of the fibres and the now consolidated results of a large amount of reliable research, it is today possible to affirm that artificial vitreous fibres are not a hazard for the workers who produce and use them. Since current production in Europe involves mostly large diameter, non respirable fibres or fibres with extremely low biopersistence, in accordance with precise European Union recommendations, we may look to the future without undue concern.
authors.affiliation: Centro di Studio e Ricerca sugli effetti biologici delle Polveri Inalate, Università degli Studi di Milano.
authors.forename: G
authors.initials: G
authors.lastname: Chiappino
mesh_terms: D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000592:standards; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D005898:Glass; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D019016:Mineral Fibers / Q000009:adverse effects* / Q000592:standards; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D016272:Occupational Health; D011009:Pneumoconiosis / Q000175:diagnosis / Q000209:etiology; D051381:Rats; D014481:United States; D014489:United States Occupational Safety and Health Administration
chemical_list: D000395:Air Pollutants, Occupational; D019016:Mineral Fibers; C009753:fiberglass