title: Pathoadaptive mutations: gene loss and variation in bacterial pathogens.
abstract: Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.
authors.affiliation: Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu
authors.forename: E V
authors.initials: EV
authors.lastname: Sokurenko
authors.forename: D L
authors.initials: DL
authors.lastname: Hasty
authors.forename: D E
authors.initials: DE
authors.lastname: Dykhuizen
mesh_terms: D000222:Adaptation, Physiological; D018407:Bacterial Physiological Phenomena; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D014644:Genetic Variation; D006801:Humans; D009154:Mutation