title: A poroid neoplasia arising close to a seborrheic keratosis and a trichoepithelioma.
abstract: A 69-year-old woman had a well-defined, slightly raised, brownish, keratotic plaque with an eccentric group of roughly circular, bluish, dome nodules on her right scapular area. Histological study revealed the presence of an eccrine poroma demonstrating features of eccrine poroma, hidroacanthoma simplex, and dermal duct tumor and arising in a lesion of seborrheic keratosis and a trichoepithelioma. In the eccrine poroma region, an area with malignant changes was evident. The findings in this case support the view of eccrine poroma as a spectrum of histological variants and the possibility of malignant transformation from a eccrine poroma towards porocarcinoma. The association with seborrheic keratosis is most probably coincidental, and the trichoepithelioma was probably due to induction of the tumoral stroma on adjacent follicular epithelia.
authors.affiliation: Department of Dermatology, Hospital General Universitario, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Nagore
authors.forename: F
authors.initials: F
authors.lastname: Díaz
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez-Motilla
authors.forename: A
authors.initials: A
authors.lastname: Prats
authors.forename: J
authors.initials: J
authors.lastname: García-Castell
authors.forename: A
authors.initials: A
authors.lastname: Aliaga
mesh_terms: D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017492:Keratosis, Seborrheic / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery