title: Manic-depression neural conduction speeds and action potential event dyscorrelation.
abstract: In manic-depressive disorder, the monotonic, humor/receptor, excess/deficit, i.e. gain, theories have prevailed for many years, even though there is increasing evidence of a timing abnormality that may or may not be related to gain. In addition, the manic-depressive course is clearly multimodal and unpredictable except in revealing but rare cases, yet the system is real, and thus presumably deterministic, clearly suggesting a dynamic instability. A wide range of disciplines was reviewed by the author. Those data that were significantly different by standard tests were considered. However, averaged values were always questioned. During this review, higher water compartmentalization differentials were found in manic-depressive patients. Also indicated, event-related potential components differed in latency correlations, suggesting action potential firing event dyscorrelation. In conclusion, the manic-depressive action potential firing events may be dyscorrelated in a space-time reference frame.
authors.affiliation: joernewton@worldnet.att.net
authors.forename: J R
authors.initials: JR
authors.lastname: Newton
mesh_terms: D000200:Action Potentials; D001714:Bipolar Disorder / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net; D009431:Neural Conduction / Q000502:physiology*; D013997:Time Factors