Limb development: Farewell to arms.
Forelimbs and hindlimbs are, clearly, quite different, and it has long been appreciated that their differences are assigned early in development; the genetic basis of these differences has been more mysterious, however. Recent work has now shown that the homeobox gene Pitx1 imparts identity to the developing hindlimb bud.
Graham
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A
Molecular Neurobiology Group, 4th floor, Hodgkin Building, Kings College London, Guys Campus, London, SE1 9RT, UK.
McGonnell
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I
D000818:Animals; D001132:Arm / Q000196:embryology*; D005314:Embryonic and Fetal Development; D006801:Humans