A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst.
Post-coating of biodegradable polylactides (PLA)/polyethylene glycol (PEG) microspheres with a gelatin film produced by dipping the microspheres into a gelatin solution to reduce the initial drug release burst was investigated. Biodegradable block PLA/PEG microspheres, prepared by w/o emulsion/solvent evaporation, showed that the hydrophilic segment PEG protruded to the sphere surface. However, these microspheres also showed a large burst release in the initial period. Post-coating of the PLA/PEG microspheres with a gelatin film by dipping the microspheres into a dilute gelatin solution effectively inhibited the initial burst release rate in the drug release tests. Post-coating of gelatin reduced 98% of the burst release. With thicker coatings, there were slower releasing rates, and the release rate can be simply related to the coating thickness.
Huang
Y Y
YY
Institute of Biomedical Engineering, College of Engineering, National Taiwan University, Taipei, Taiwan, ROC. yyhuang@ha.mc.ntu.edu.tw
Chung
T W
TW
Tzeng
T W
TW
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001673:Biodegradation, Environmental; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005780:Gelatin / Q000737:chemistry; D007773:Lactates / Q000138:chemical synthesis / Q000737:chemistry*; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry; D008863:Microspheres; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011433:Propranolol / Q000008:administration & dosage / Q000737:chemistry
D000889:Anti-Arrhythmia Agents; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007773:Lactates; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D005780:Gelatin; D008012:Lidocaine; D011433:Propranolol