Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
Reaction of C-(1-bromo-1-deoxy-beta-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D-glucopyanosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.
Osz
E
E
Department of Organic Chemistry, Lajos Kossuth University, Debrecen, Hungary.
Somsák
L
L
Szilágyi
L
L
Kovács
L
L
Docsa
T
T
Tóth
B
B
Gergely
P
P
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D011817:Rabbits
D004791:Enzyme Inhibitors; D006005:Phosphorylases