title: Mechanotransduction in bone--role of the lacuno-canalicular network.
abstract: The capacity of bone tissue to alter its mass and structure in response to mechanical demands has long been recognized but the cellular mechanisms involved remained poorly understood. Over the last several years significant progress has been made in this field, which we will try to summarize. These studies emphasize the role of osteocytes as the professional mechanosensory cells of bone, and the lacuno-canalicular porosity as the structure that mediates mechanosensing. Strain-derived flow of interstitial fluid through this porosity seems to mechanically activate the osteocytes, as well as ensuring transport of cell signaling molecules and nutrients and waste products. This concept allows an explanation of local bone gain and loss, as well as remodeling in response to fatigue damage, as processes supervised by mechanosensitive osteocytes.
authors.affiliation: ACTA-Vrije Universiteit, Department of Oral Cell Biology, Amsterdam, The Netherlands. EH.Burger.OCB.ACTA@med.vu.nl
authors.forename: E H
authors.initials: EH
authors.lastname: Burger
authors.forename: J
authors.initials: J
authors.lastname: Klein-Nulend
mesh_terms: D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010011:Osteocytes / Q000648:ultrastructure; D015398:Signal Transduction; D014893:Weightlessness