Cyclosporin-A inhibits lipid peroxidation after spinal cord injury in rats.
Besides its immunosuppressive/anti-inflammatory activity, cyclosporin-A (CsA) may protect damaged tissues from lipid peroxidation (LP) by free radicals. To determine the effect of CsA on LP spinal cord (SC) injury, Wistar rats were treated with either vehicle or CsA (2.5 mg/kg per 12 h i.p.) 1, 2, 6 or 12 h after SC trauma by T8-T9 spinal cord contusion, analyzing LP 24 h after injury at the lesion site by the lipid fluorescent products formation method. CsA significantly diminished LP to levels below control values after contusion (P < 0.05). The greater inhibition was observed when CsA was given during the first 6 h after injury, furthermore, animals showed a significant clinical improvement. Results show that CsA may be beneficial to injured tissue by inhibiting the levels of LP.
Diaz-Ruiz
A
A
Unidad de Investigación Médica en Enfermedades Neurológicas, H.E., C.M.N. Siglo XXI, IMSS, Mexico, Mexico.
Rios
C
C
Duarte
I
I
Correa
D
D
Guizar-Sahagun
G
G
Grijalva
I
I
Ibarra
A
A
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000378:metabolism*
D007166:Immunosuppressive Agents; D016572:Cyclosporine