title: [New evidence of the antigenic relation between the viruses of epidemic neuropathy and the human nervous system. A study of the immune cellular response in patients with epidemic neuropathy and controls. A review of the topic].
abstract: A series of experiments was made at the Virology Department of the "Pedro Kourí" Institute of Tropical Medicine aimed at obtaining new evidences on the possible antigenic relations existing between the viruses isolated from patients with epidemic neuropathy and the structures of the human nervous system. According to the results it may be finally inferred that the persistence and/or autoimmunity may be considered as mechanisms through which the studied viruses participate in the etiopathogenesis of the epidemic neuropathy in Cuba. For future experiments it is very important to identify the possible viral epitopes involved in the molecular mimicry that are responsible for the probable autoimmune mechanisms or for the viral persistence.
authors.affiliation: Instituto de Medicina Tropical Pedro Kourí, Ciudad de La Habana, Cuba. ciipk@nfomed.sld.cu
authors.forename: B
authors.initials: B
authors.lastname: Sierra Vázquez
authors.forename: P
authors.initials: P
authors.lastname: Más Lago
authors.forename: A B
authors.initials: AB
authors.lastname: Pérez
authors.forename: L
authors.initials: L
authors.lastname: Sarmiento Pérez
authors.forename: M
authors.initials: M
authors.lastname: Bello Corredor
authors.forename: I
authors.initials: I
authors.lastname: Avalos Redón
authors.forename: S
authors.initials: S
authors.lastname: Resik Aguirre
authors.forename: T
authors.initials: T
authors.lastname: Denny
authors.lastname: Gissel García
authors.forename: M G
authors.initials: MG
authors.lastname: Guzmán Tirado
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D000941:Antigens / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000821:virology; D003462:Cuba / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000276:immunology* / Q000821:virology; D010523:Peripheral Nervous System Diseases / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000276:immunology* / Q000821:virology; D011817:Rabbits; D014780:Viruses / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000941:Antigens; D000956:Antigens, Viral