title: Non-metastatic Ewing's sarcoma: twenty years of experience suggests that surgery is a prime factor for successful multimodality therapy.
abstract: Eighty-five patients (37 female, 48 male; median age 14 years) with non-metastatic Ewing's sarcoma received definitive treatment at the University of Texas M.D. Anderson Cancer Center between 1969 and 1988. Multidisciplinary therapy was administered as follows: combination chemotherapy (CC) and local radiotherapy (XRT): 65 patients; CC, XRT and surgery, 19 patients; and XRT and surgery, 1 patient. This permitted a 10-20 year follow-up for 75% of our patients. The overall survival at 5 and 10-20 years was 46.1%, and 37.2%, respectively. At 5 years, 80.5% of live patients had control of local disease. The influence of sex, age, ethnicity, primary site, size, lactic dehydrogenase (LDH) level, presence or absence of systemic symptoms, and XRT dose (<60 Gy and </=60 Gy) was analyzed and was not found to be of prognostic significance in survival. The presence of a soft tissue mass at diagnosis was found to be a significant unfavorable prognostic variable. Nine of 11 patient who underwent resection after CC and/or XRT had residual tumor in the surgical specimen. Patients who received surgery as part of the planned treatment of their primary tumor had significantly better local control and disease-free survival than those who did not undergo resection. Complications in long-term survivors are described.
authors.affiliation: Department of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Givens
authors.forename: S Y
authors.initials: SY
authors.lastname: Woo
authors.forename: L Y
authors.initials: LY
authors.lastname: Huang
authors.forename: T A
authors.initials: TA
authors.lastname: Rich
authors.forename: M H
authors.initials: MH
authors.lastname: Maor
authors.forename: A
authors.initials: A
authors.lastname: Cangir
authors.forename: J A
authors.initials: JA
authors.lastname: Murray
authors.forename: M J
authors.initials: MJ
authors.lastname: Oswald
authors.forename: L J
authors.initials: LJ
authors.lastname: Peters
authors.forename: N
authors.initials: N
authors.lastname: Jaffe
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery*