Inhibition of human telomerase by PNA-cationic peptide conjugates.
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
Harrison
J G
JG
Department of Chemistry, University of Cambridge, UK.
Frier
C
C
Laurant
R
R
Dennis
R
R
Raney
K D
KD
Balasubramanian
S
S
D002412:Cations / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D020128:Inhibitory Concentration 50; D008957:Models, Genetic; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000037:antagonists & inhibitors*; D013696:Temperature
D002412:Cations; D020135:Peptide Nucleic Acids; D019098:Telomerase