Colonic ulceration caused by administration of loxoprofen sodium.
A 54-year-old female with chronic headache was admitted to our hospital because of hematochezia. She had routinely taken loxoprofen sodium because of severe headache. Emergent colonoscopic examination revealed ulceration of the cecum. After administration of loxoprofen sodium was discontinued and administration of sulfasalazine was initiated, her intestinal bleeding subsided. Two months after discontinuation of loxoprofen sodium, the colonoscopic examination revealed scar formation at the site of cecal ulceration. In this case, it was conceivable that the administration of loxoprofen sodium might have induced colonic ulceration.
Nakase
H
H
Division of Gastroenterology, Nishi-Kobe, Medical Center, Kobe.
Itani
T
T
Mimura
J
J
Kawasaki
T
T
Komori
H
H
Hashimoto
K
K
Chiba
T
T
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D005500:Follow-Up Studies; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010666:Phenylpropionates / Q000009:adverse effects*; D012460:Sulfasalazine / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D010666:Phenylpropionates; C040656:loxoprofen; D012460:Sulfasalazine