Evidence for de novo biosynthesis of the polyketide fragment of diaulusterol A by the northeastern pacific dorid nudibranch diaulula sandiegensis
Stable isotope incorporation experiments using sodium [1, 2-13C2]acetate have demonstrated that the 3-hydroxybutyrate substituent of diaulusterol A (1) is biosynthesized de novo by the dorid nudibranch Diaulula sandiegensis. There was no evidence for acetate incorporation into the steroid portion of 1, nor were radiolabeled mevalonate or cholesterol incorporated.
Kubanek
J
Departments of Chemistry and Oceanography-Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Andersen
RJ