title: Antiinflammatory activity of Muktashukti bhasma.
abstract: Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, India.
authors.forename: O
authors.initials: O
authors.lastname: Chauhan
authors.forename: J L
authors.initials: JL
authors.lastname: Godhwani
authors.forename: N K
authors.initials: NK
authors.lastname: Khanna
authors.forename: V K
authors.initials: VK
authors.lastname: Pendse
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use; D000504:Aloe / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008515:Medicine, Ayurvedic; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D019342:Acetic Acid