[Relationship between structural characteristics of eukaryotic DNA and its sensitivity to the effect of low intensity ionizing radiation].
Analysis of literature and own experimental data as well as the up-to-date conception of heterogeneous damage of cell genome allows the author to conclude that there are some sensitive regions in DNA, which are the sites of DNA attachment to nuclear matrix. The role of conformational changes in chromatin is considered in formation of long-term consequences of low-dose irradiation of mammalian and human.
Zhizhina
G P
GP
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow. chembio@glas.apc.org
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure; D002843:Chromatin / Q000528:radiation effects / Q000648:ultrastructure; D004247:DNA / Q000528:radiation effects* / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000528:radiation effects / Q000648:ultrastructure; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008099:Liver / Q000528:radiation effects / Q000648:ultrastructure; D051379:Mice; D009690:Nucleic Acid Conformation; D013154:Spleen / Q000528:radiation effects / Q000648:ultrastructure
D002843:Chromatin; D004273:DNA, Neoplasm; D004247:DNA