title: Phylogenetic perspectives in innate immunity.
abstract: The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.
authors.affiliation: Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France. jhoff@ibmc.u-strasbg.fr
authors.forename: J A
authors.initials: JA
authors.lastname: Hoffmann
authors.forename: F C
authors.initials: FC
authors.lastname: Kafatos
authors.forename: C A
authors.initials: CA
authors.lastname: Janeway
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
mesh_terms: D000818:Animals; D009033:Culicidae / Q000276:immunology / Q000382:microbiology; D004330:Drosophila / Q000276:immunology / Q000382:microbiology; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D007303:Insect Vectors / Q000276:immunology / Q000382:microbiology; D008322:Mammals / Q000276:immunology; D018448:Models, Immunological; D010587:Phagocytosis; D010802:Phylogeny; D011506:Proteins / Q000378:metabolism
chemical_list: D011506:Proteins