title: The spectrum of ischaemic colitis.
abstract: OBJECTIVE
  Ischaemic colitis is generally considered a disease of the elderly with considerable cardiovascular morbidity. We aimed to determine the effect of age, co-morbidity and clinical presentation on type, severity and anatomy of involvement of ischaemic colitis. Thrombophilic tendencies have been poorly studied and coagulation status was performed in available patients.
  
  
  METHODS
  Retrospective case identification with prospective follow-up.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Twenty-four patients (16 female, mean age 64 years) with ischaemic colitis.
  
  
  METHODS
  Blood analysis for clotting tendencies.
  
  
  METHODS
  Operation rates, death rates and frequency of clotting abnormalities.
  
  
  RESULTS
  Five patients (21%) were below the age of 45, and seven of the 24 had died by the time of follow-up. Four had died of ischaemic colitis during the acute episode. The four patients that died of ischaemic colitis had a more extensive and more severe type of disease and presented with worse clinical features. The main predisposing factors were ischaemic heart disease in 12 (50%) and malignancy in five (21%). Six of the 24 cases (25%) had right-sided lesions and this conferred a good prognosis. Shock, peritonism, extensive disease and uncontrolled atrial fibrillation were all poor prognostic factors. Clotting factor abnormalities could be detected in three of nine patients despite a time lapse between assay and episode of ischaemic colitis.
  
  
  CONCLUSIONS
  Ischaemic colitis appears to have two patterns of severity. Anatomical distribution is more variable than a developmental explanation of the vascular supply. Clotting abnormalities may be detected in a minority even on retrospective testing.
authors.affiliation: Department of Medicine, University of Edinburgh, Western General Hospital, UK.
authors.forename: I D
authors.initials: ID
authors.lastname: Arnott
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: A
authors.initials: A
authors.lastname: Ferguson
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications; D001778:Blood Coagulation Disorders / Q000150:complications; D001779:Blood Coagulation Factors / Q000032:analysis; D002423:Cause of Death; D017091:Colitis, Ischemic / Q000145:classification / Q000150:complications / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D009369:Neoplasms / Q000150:complications; D010538:Peritonitis / Q000150:complications; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D012769:Shock / Q000150:complications; D015996:Survival Rate; D013927:Thrombosis / Q000150:complications
chemical_list: D001779:Blood Coagulation Factors