title: Examination of the polymorphism of piroxicam in connection with the preparation of a new "soft-patch" type pharmaceutical dosage form.
abstract: The influence of different solvents (propylene glycol, glycerol, ethanol), as well as different technological procedures (melting, rapid and slow cooling), on the formation of polymorphous piroxicam modifications was examined in the course of the elaboration of a "soft-patch" type of semisolid pharmaceutical dosage form. The thermodynamical behavior, some physicochemical properties (such as melting point, dissolution rate), and infrared (IR) spectrum of the formed (needle and cubic) crystal modifications were studied, and the possibilities of their formation and their avoidance were examined.
authors.affiliation: Semmelweis University of Medical Sciences, Pharmaceutical Institute, Budapest, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Csóka
authors.forename: E
authors.initials: E
authors.lastname: Balogh
authors.forename: S
authors.initials: S
authors.lastname: Marton
authors.forename: E
authors.initials: E
authors.lastname: Farkas
authors.forename: I
authors.initials: I
authors.lastname: Rácz
mesh_terms: D000279:Administration, Cutaneous; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004355:Drug Stability; D005782:Gels / Q000737:chemistry; D006358:Hot Temperature; D008855:Microscopy, Electron, Scanning; D010894:Piroxicam / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D012997:Solvents; D010894:Piroxicam