title: Clinical and experimental demonstration of complete healing of porous Dacron patch grafts used for closure of the arteriotomy after carotid endarterectomy.
abstract: A clinical porous Dacron patch graft used for closure after carotid endarterectomy was explanted 24 hr postmortem during autopsy. There had been no TIAs or stroke postoperatively, and the cause of death was congestive heart failure. The graft had been implanted for 25 months. The specimen had a very clean surface, was completely incorporated by full-wall tissue ingrowth, and the flow surface was covered with well-organized neointima containing endothelial cells and smooth muscle cells, as confirmed by immunological studies. For comparison, animal experiments were performed. In both the clinical and experimental specimens the carotid patches were patent without neointimal compromise of the lumen, and their healing patterns were similar, with endothelium on the flow surface.
authors.affiliation: Hope Heart Institute, Providence Seattle Medical Center, WA 98122, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: M H
authors.initials: MH
authors.lastname: Wu
authors.forename: L R
authors.initials: LR
authors.lastname: Sauvage
mesh_terms: D000368:Aged; D000818:Animals; D001807:Blood Vessel Prosthesis; D002343:Carotid Artery, Internal / Q000601:surgery; D004285:Dogs; D016894:Endarterectomy, Carotid; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006801:Humans; D011093:Polyethylene Terephthalates; D016062:Porosity; D014945:Wound Healing / Q000502:physiology
chemical_list: D011093:Polyethylene Terephthalates