title: Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position.
abstract: Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1 ,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the anti-rhinoviral activity. A short and efficient means for the construction of the imidazo nucleus as well as biological evaluation of the final compounds are disclosed.
authors.affiliation: Centro de Investigación Lilly S.A., Alcobendas (Madrid)-Spain. hamdouchi_chafiq@lilly.com
authors.forename: C
authors.initials: C
authors.lastname: Hamdouchi
authors.forename: J
authors.initials: J
authors.lastname: Ezquerra
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
authors.forename: J J
authors.initials: JJ
authors.lastname: Vaquero
authors.forename: J
authors.initials: J
authors.lastname: Alvarez-Builla
authors.forename: B A
authors.initials: BA
authors.lastname: Heinz
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012229:Rhinovirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011725:Pyridines