title: Primary epithelioid leiomyosarcoma of bone. Case report and literature review.
abstract: We describe an epithelioid leiomyosarcoma of bone located in the right knee of a 51-year-old woman. Plain radiograph and CT scan revealed a poorly defined lytic and destructive mass in the upper metaepiphyseal right tibia which involved surrounding soft tissues. The lesion was composed of proliferating monotonous round cells with a high mitotic activity with scanty intersecting spindle cell fascicles. Immunohistochemistry of both areas demonstrated a strong positivity for actin (HHF-35 and alpha-SMA) and vimentin, and negative reactions for desmin, keratin (AE1 AE3), epithelial membrane antigen, S-100 protein, factor VIII-related antigen, CD 31 and CD 34. Ultrastructural study confirmed a diagnosis of leiomyosarcoma. This is the first detailed description of the microscopic and radiological features of primary epithelioid leiomyosarcoma of bone.
authors.affiliation: Department of Pathology, University Hospital La Paz, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lopez-Barea
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez-Peralto
authors.forename: S
authors.initials: S
authors.lastname: Sanchez-Herrera
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez-Lopez
authors.forename: E
authors.initials: E
authors.lastname: Burgos-Lizaldez
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D002455:Cell Division; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D011877:Radionuclide Imaging; D016698:Technetium Tc 99m Pyrophosphate; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D016698:Technetium Tc 99m Pyrophosphate