title: Polymeric gadolinium chelate magnetic resonance imaging contrast agents: design, synthesis, and properties.
abstract: We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.
authors.affiliation: Torsten Almén Research Center, Nycomed Amersham Imaging, 466 Devon Park Drive, Wayne, Pennsylvania 19087, USA. david.ladd@US.Nycomed-Amersham.com
authors.forename: D L
authors.initials: DL
authors.lastname: Ladd
authors.forename: R
authors.initials: R
authors.lastname: Hollister
authors.forename: X
authors.initials: X
authors.lastname: Peng
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: G
authors.initials: G
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Delecki
authors.forename: R A
authors.initials: RA
authors.lastname: Snow
authors.forename: J L
authors.initials: JL
authors.lastname: Toner
authors.forename: K
authors.initials: K
authors.lastname: Kellar
authors.forename: J
authors.initials: J
authors.lastname: Eck
authors.forename: V C
authors.initials: VC
authors.lastname: Desai
authors.forename: G
authors.initials: G
authors.lastname: Raymond
authors.forename: L B
authors.initials: LB
authors.lastname: Kinter
authors.forename: T S
authors.initials: TS
authors.lastname: Desser
authors.forename: D L
authors.initials: DL
authors.lastname: Rubin
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D015195:Drug Design; D005240:Feasibility Studies; D005682:Gadolinium / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D051381:Rats
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011108:Polymers; D005682:Gadolinium