[Mechanisms of selective vulnerability of cholinergic neurons to neurotoxic stimuli].
Preferential loss of cholinergic neurons in course of several encephalopathies may result from the fact that they utilize acetyl-CoA not only for energy production, but also for acetylcholine synthesis. Changes in activities of acetyl-CoA metabolizing enzymes and shifts in acetyl-CoA compartmentalization, found in different animal models of brain pathologies and in human post mortem brain, are discussed in therms of their impact on cholinergic system integrity.
Szutowicz
A
A
Katedra i Zakład Biochemii Klinicznej Akademii Medycznej w Gdańsku.
Tomaszewicz
M
M
Jankowska
A
A
Madziar
B
B
Bielarczyk
H
H
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000109:Acetylcholine / Q000096:biosynthesis; D000535:Aluminum / Q000633:toxicity; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D002799:Cholinergic Fibers / Q000187:drug effects / Q000502:physiology*; D003929:Diabetic Neuropathies / Q000378:metabolism; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*
D000105:Acetyl Coenzyme A; D000535:Aluminum; D000109:Acetylcholine