title: Secondary stroke prevention in atrial fibrillation: indications, risks, and benefits.
abstract: Patients with nonrheumatic atrial fibrillation (NRAF) and a recent transient ischemic attack (TIA) or nondisabling ischemic stroke have a high risk of stroke recurrence of about 12% per year. Two randomized clinical trials have shown that oral anticoagulant therapy reduces the risk by two thirds, very similar to the benefit in primary prevention. The optimal intensity is INR 2.0-3.0. In case of a containdication to AC, aspirin and ibuprofen are safe, but less effective, alternatives. During the first 2 weeks following AF-related major stroke, the benefit of subcutaneous heparin is offset by a higher risk of secondary cerebral bleeding, and therefore cannot be recommended, at present, during that period. The risk of stroke recurrence can be predicted by means of easily available clinical information.
authors.affiliation: Department of Neurology, University Hospital Rotterdam, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Koudstaal
authors.forename: A
authors.initials: A
authors.lastname: Koudstaal
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D001241:Aspirin; D007052:Ibuprofen