Complex interactions between skeletal muscle ryanodine receptor and dihydropyridine receptor proteins.
Evidence for functional interactions between the Ca2+ release channel in the skeletal muscle sarcoplasmic reticulum (the ryanodine receptor) and the L-type Ca2+ channel in the sarcolemma (the dihydropyridine receptor), leading to excitation-contraction coupling, is reviewed and experimental systems used to identify candidate sites of interaction are outlined.
Leong
P
P
Banting and Best Department of Medical Research, Charles H. Best Institute, University of Toronto, ON, Canada.
MacLennan
D H
DH
D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000502:physiology*; D020746:Calcium Channels, L-Type; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism*; D011485:Protein Binding; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000502:physiology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D019837:Ryanodine Receptor Calcium Release Channel