Relationships between age, dehydro-epiandrosterone sulphate and plasma glucose in healthy men.
BACKGROUND
dehydro-epiandrosterone sulphate (DHEAS) has been reported to ameliorate diabetes mellitus in rats.


OBJECTIVE
we investigated the relationships between plasma glucose, age, serum DHEAS and weight in healthy men.


METHODS
we measured the serum DHEAS, fasting plasma glucose, plasma cortisol and body mass index in 169 subjects (mean age 46.5 years).


RESULTS
there was a significant decline in serum DHEAS with age (P < 0.0001). Multiple linear regression showed significant relationships with plasma glucose for all measured variables. Age was not a significant determinant of plasma glucose after adjusting for log serum DHEAS, body mass index and log serum cortisol.


CONCLUSIONS
a lowered serum DHEAS is paralleled by an elevated plasma glucose within the normal reference interval, and this may contribute to the rise in fasting plasma glucose which occurs with ageing.
Thomas
N
N
Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, SA, Australia.
Morris
H A
HA
Scopacasa
F
F
Wishart
J M
JM
Need
A G
AG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D019314:Dehydroepiandrosterone Sulfate