Ambulant photodynamic therapy of superficial malignomas with 5-ALA in combination with folic acid and use of noncoherent light.
This study reports our first results of ambulant photodynamic treatment with 5-aminolevulinic acid (5-ALA) in combination with folic acid and subsequent illumination with a noncoherent light source. The compound was topically applied to avoid total body skin sensitivity which occurs in the case of systemic administration. If no therapeutic response could be proved, we added folic acid to 5-ALA for a further treatment attempt. Illumination was performed by broad band red thermic light to also excitate reaction products with absorption bands located near to that of the sensitizer. As a result, we observed a response in all cases, however, in some cases only after the addition of folic acid.
Jindra
R H
RH
Ludwig Boltzmann Institute for Clinical Oncology and Photodynamic Therapy, Vienna, Austria.
Kubin
A
A
Kolbabek
H
H
Alth
G
G
Dobrowsky
W
W
D000287:Administration, Topical; D000553:Ambulatory Care; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; D005492:Folic Acid