title: Acquired factor VIII inhibitor in a non-hemophilic patient with chronic hepatitis C viral infection.
abstract: Production of coagulation factor VIII inhibitor is rarely encountered in non-hemophilic patients. A 63-year-old Japanese male suffered from severe bleeding tendency caused by this inhibitor. Although he did not have malignancy or collagen disease, he had chronic hepatitis C virus (HCV) infection. Although HCV is known to induce production of various autoimmune antibodies, this may be the first report of a case with both acquired factor VIII inhibitor and HCV infection.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Sugishita
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Shiratori
authors.forename: M
authors.initials: M
authors.lastname: Omata
mesh_terms: D001779:Blood Coagulation Factors / Q000032:analysis; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000276:immunology; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006467:Hemophilia A / Q000097:blood; D016174:Hepacivirus / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis
chemical_list: D001779:Blood Coagulation Factors; D005938:Glucocorticoids; D018937:Hepatitis C Antibodies; D005169:Factor VIII