Heme oxygenase inhibitors transiently increase serum ferritin concentrations without altering other acute-phase reactants in man.
Sn protoporphyrin (SnPP) and Sn mesoporphyrin (SnMP), potent inhibitors of heme oxygenase (HO), significantly suppress bilirubin production, lower serum and biliary bilirubin levels and increase biliary heme output in animals and man. In this study, 20 healthy volunteers, 7 patients with primary biliary cirrhosis and 4 patients with idiopathic hemochromatosis were treated with SnPP and 4 healthy volunteers with SnMP. In all cases, serum ferritin levels increased substantially but transiently after administration of these HO inhibitors. Values returned to baseline within a few days. Infusion of hematin in 4 healthy volunteers did not significantly affect ferritin levels. No increases occurred in 7 other acute-phase reactants. The observation that these HO inhibitors transiently increase serum ferritin levels implies a link between ferritin, iron metabolism and HO activity which may be usefully explored in disorders of iron metabolism.
Berglund
L
L
Department of Medicine, Columbia University, Rockefeller University Hospital, New York, NY 10021, USA.
Galbraith
R A
RA
Emtestam
L
L
Drummond
G S
GS
Angelin
B
B
Kappas
A
A
D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005293:Ferritins / Q000097:blood*; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors*; D006801:Humans; D008665:Metalloporphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology*
D000209:Acute-Phase Proteins; D004791:Enzyme Inhibitors; D008665:Metalloporphyrins; D011524:Protoporphyrins; C055421:tin mesoporphyrin; D005293:Ferritins; C032628:tin protoporphyrin IX; D006419:Heme Oxygenase (Decyclizing)