title: [Diovan efficacy and tolerance in mild and moderate hypertension].
abstract: OBJECTIVE
  To study clinical effectiveness and tolerance of diovan, a new angiotensin-II antagonist, in patients with mild and moderate blood hypertension (BH).
  
  
  METHODS
  The trial included 20 patients (13 males and 7 females) aged 35-60 years with mild and moderate BH. All the patients received diovan (valsartan) for 8 weeks in a dose 80 mg/day. If the hypotensive effect was inadequate, the dose was increased to 160 mg/day.
  
  
  RESULTS
  2-week treatment with diovan brought a significant fall of both systolic and diastolic blood pressure. In 8 weeks the hypotensive effect enhanced. Lowering of diastolic BP to 90 mm Hg or at least by 10% was achieved in 90% of the patients. Tolerance was good, unfavorable metabolic shifts were absent.
  
  
  CONCLUSIONS
  Diovan proved to be effective and safe in therapy of patients with mild and moderate BH.
authors.forename: A N
authors.initials: AN
authors.lastname: Zakirova
authors.forename: N E
authors.initials: NE
authors.lastname: Zakirova
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000037:antagonists & inhibitors; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004342:Drug Hypersensitivity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012449:Safety; D012720:Severity of Illness Index; D013777:Tetrazoles / Q000627:therapeutic use*; D016896:Treatment Outcome; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000068756:Valsartan
chemical_list: D000959:Antihypertensive Agents; D013777:Tetrazoles; D000804:Angiotensin II; D000068756:Valsartan; D014633:Valine