T-cell clonality in immune responses.
Recent methodological advances allow the analysis of clonal composition within T-cell subsets. Here, Mala Maini and colleagues review the available data on clonality in acute immune responses and steady-state situations. They highlight and explore reasons for the striking differences in clonality between the CD4+ and CD8+ T-cell subsets.
Maini
M K
MK
Dept of Sexually Transmitted Diseases, Royal Free and University College Medical School, Mortimer Market off Capper St, London, UK WC1E 6AU. m.maini@ucl.ac.uk
Casorati
G
G
Dellabona
P
P
Wack
A
A
Beverley
P C
PC
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013997:Time Factors; D014777:Virus Diseases / Q000276:immunology