title: AKAPs: from structure to function.
abstract: Compartmentalization of signalling molecules through association with anchoring proteins ensures specificity in signal transduction by placing enzymes close to their appropriate effectors and substrates. For example, 'A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit of cAMP-dependent protein kinase (PKA) to direct the kinase to discrete intracellular locations. Recently, functional studies aimed at disrupting AKAP-PKA complexes have demonstrated a role for anchored PKA in various cellular processes, including gene transcription, hormone-mediated insulin secretion and ion-channel modulation. By binding to additional signalling molecules, AKAPs might function to coordinate multiple components of signal-transduction pathways.
authors.affiliation: Howard Hughes Medical Institute, L-474, Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
authors.forename: M
authors.initials: M
authors.lastname: Colledge
authors.forename: J D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism* / Q000502:physiology*; D002451:Cell Compartmentation / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology*; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases