Relationship between antidepressant partial and nonresponse and subsequent response to antidepressant augmentation.
OBJECTIVE
To evaluate the relationship between the degree of antidepressant nonresponse and subsequent response to lithium and triiodothyronine (T3) augmentation.


METHODS
This is a retrospective analysis of data combined from two previous controlled studies of lithium and triiodothyronine augmentation of tricyclic antidepressants.


RESULTS
There was no difference in the rate of augmentation response between partial and nonresponders to tricyclic antidepressant treatment.


CONCLUSIONS
Augmentation response does not appear to be related to the degree of nonresponse to the preceding antidepressant trial.
Joffe
R T
RT
Department of Psychiatry, McMaster University, Hamilton, ON, Canada.
Levitt
A J
AJ
D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000097:blood / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D003891:Desipramine / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000627:therapeutic use*; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D012189:Retrospective Studies; D014284:Triiodothyronine / Q000187:drug effects*
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D014284:Triiodothyronine; D008094:Lithium; D007099:Imipramine; D003891:Desipramine