Linezolid activity compared to those of selected macrolides and other agents against aerobic and anaerobic pathogens isolated from soft tissue bite infections in humans.
Linezolid was tested against 420 aerobes and anaerobes, including 148 Pasteurella isolates, by an agar dilution method. Linezolid was active against all Pasteurella multocida subsp. multocida and P. multocida subsp. septica isolates and most Pasteurella canis, Pasteurella dagmatis, and Pasteurella stomatis isolates. The MIC was </=2 microg/ml for staphylococci, streptococci, EF-4b, Weeksella zoohelcum, Fusobacterium nucleatum, other fusobacteria, Porphyromonas spp., Prevotella spp., peptostreptococci, and almost all Bacteroides tectum isolates.
Goldstein
E J
EJ
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA. EJCGMD@aol.com
Citron
D M
DM
Merriam
C V
CV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001733:Bites and Stings / Q000150:complications*; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D018461:Soft Tissue Infections / Q000382:microbiology*; D014946:Wound Infection / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D018942:Macrolides