title: Radiation therapy of metastatic spinal cord compression. Multidisciplinary team diagnosis and treatment.
abstract: OBJECTIVE
  To evaluate the effectiveness of a multidisciplinary approach to spinal cord compression (SCC) in accordance with prospective protocol, providing a uniform approach to diagnosis, decision making concerning optimal treatment modality in any particular case of SCC, treatment performance and evaluation of treatment results. The SCC patients treated by radiation therapy are described.
  
  
  METHODS
  Patients with SCC were examined and treated by a multidisciplinary team consisting of a neurologist, radiologist, oncologist, orthopedic surgeon, and neurosurgeon. Seventy-nine patients for whom radiation was recommended received a 30 Gy radiation dose to a compression-causing mass and course of high dose dexamethasone. Three fractions of 5 Gy and 5 fractions 3 Gy each were delivered by Co60 or 8 MV photon beam in 12 days. Treatment outcome was essentially evaluated by ambulation capabilities which were considered to be the main problem of SCC. Changes in other neurologic motor, sensory and autonomic disturbances were also evaluated.
  
  
  RESULTS
  Seventy-two percent of the patients were already non-ambulatory at diagnosis. The first symptom was motor deficiency in only 33% of them while in all other cases it was pain. Ambulation capability was the main prognosticator of treatment outcome; 90% of patients who were ambulatory before treatment remained so while 33% of the non-ambulatory patients regained their ability to walk. The grade of motor disturbance was also an important variable: among the non-ambulatory patients, 50% of the paretic but only 14% of the plegic ones became ambulatory. Overall, 51% of the study patients were ambulatory after undergoing radiation. The ambulatory state after treatment was the main predictor for survival.
  
  
  CONCLUSIONS
  Close cooperation of a multidisciplinary team in diagnosis and treatment according to the above protocol enabled the achievement of good results of radiation treatment in SCC. Early diagnosis and early treatment should further enhance therapeutic outcome.
authors.affiliation: Department of Oncology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel. kfelix@iol.co.il
authors.forename: F
authors.initials: F
authors.lastname: Kovner
authors.forename: S
authors.initials: S
authors.lastname: Spigel
authors.forename: I
authors.initials: I
authors.lastname: Rider
authors.forename: I
authors.initials: I
authors.lastname: Otremsky
authors.forename: I
authors.initials: I
authors.lastname: Ron
authors.forename: E
authors.initials: E
authors.lastname: Shohat
authors.forename: J M
authors.initials: JM
authors.lastname: Rabey
authors.forename: J
authors.initials: J
authors.lastname: Avram
authors.forename: O
authors.initials: O
authors.lastname: Merimsky
authors.forename: N
authors.initials: N
authors.lastname: Wigler
authors.forename: S
authors.initials: S
authors.lastname: Chaitchik
authors.forename: M
authors.initials: M
authors.lastname: Inbar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010146:Pain; D010348:Patient Care Team; D011471:Prostatic Neoplasms / Q000473:pathology; D013117:Spinal Cord Compression / Q000175:diagnosis / Q000209:etiology* / Q000532:radiotherapy; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary*