title: ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.
abstract: ACTH is the standard treatment for infantile spasms (IS) in North America. Recent reports showed that vigabatrin is a valuable treatment for IS, but comparative studies with ACTH are limited. In this study, we compare the effectiveness of ACTH versus vigabatrin on IS. Our results support that vigabatrin is as effective as and better tolerated than ACTH. Because of their similar efficacy, we believe that vigabatrin should be the first intention drug for the treatment of IS.
authors.affiliation: Department of Pediatrics (Neurology), Université de Montréal, Hôpital Sainte-Justine, Québec, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Cossette
authors.forename: J J
authors.initials: JJ
authors.lastname: Riviello
authors.forename: L
authors.initials: L
authors.lastname: Carmant
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000009:adverse effects / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013036:Spasms, Infantile / Q000188:drug therapy*; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; D000324:Adrenocorticotropic Hormone; D020888:Vigabatrin