Suppressive effect of anticardiolipin antibody on the proliferation of human umbilical vein endothelial cells.
OBJECTIVE
To determine whether sera that show a positive anticardiolipin test result have a suppressive effect on the proliferation of endothelial cells collected from human umbilical veins.


METHODS
Retrospective in vitro study.


METHODS
University hospital outpatient clinic for the treatment of infertility.


METHODS
Thirteen patients with recurrent fetal miscarriages who were positive for anticardiolipin antibody and 14 patients with recurrent miscarriages who were negative for anticardiolipin antibody.


METHODS
Serum was obtained from each patient.


METHODS
Suppressive effect of the sera on the culture of human umbilical vein endothelial cells.


RESULTS
The proliferation of human umbilical vein endothelial cells decreased significantly in cultures that contained sera showing positive anticardiolipin antibody activity that had been collected from patients with recurrent fetal miscarriages.


CONCLUSIONS
The results strongly suggest that anticardiolipin antibody has a suppressive effect on the proliferation of human umbilical vein endothelial cells.
Arakawa
M
M
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
Takakuwa
K
K
Honda
K
K
Tamura
M
M
Kurabayashi
T
T
Tanaka
K
K
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000494:pharmacology*; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000166:cytology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies; D014471:Umbilical Veins / Q000166:cytology*
D017153:Antibodies, Anticardiolipin; D004247:DNA