Inhibitory effects of Ougi-keishi-gomotsu-to, a traditional herbal medicine, on lipid peroxidation and protein oxidative modification of mouse brain homogenate induced by copper.
Ougi-Keishi-gomotsu-to a traditional herbal medicine, is used clinically for patients with abnormal sensations and pain in the legs in neuropathy. It was shown to have inhibitory effects on lipid peroxidation and protein oxidative modification of brain homogenate induced by copper. Its effect was stronger than those of mannitol and alpha-tocopherol as free radical scavenger and antioxidant. These results demonstrated that Ougi-kelshi-gomotsu-to has antioxidative effects on neuron injury derived from oxidative stress induced by metal.
Toda
S
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Osaka, Japan.
Yase
Y
Y
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003300:Copper / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005609:Free Radicals; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010084:Oxidation-Reduction
D004365:Drugs, Chinese Herbal; D005609:Free Radicals; D009419:Nerve Tissue Proteins; C120251:ougi-keishi-gomotsu-to; D003300:Copper