Pathoadaptive mutations: gene loss and variation in bacterial pathogens.
Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.
Sokurenko
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Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu
Hasty
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Dykhuizen
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D000222:Adaptation, Physiological; D018407:Bacterial Physiological Phenomena; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D014644:Genetic Variation; D006801:Humans; D009154:Mutation