Molecular epidemiological survey of penicillin-resistant Streptococcus pneumoniae from Asia, Europe, and North America.
One hundred penicillin-resistant Streptococcus pneumoniae (PRSP) strains from Asia, Europe, and North America were analyzed using pulsed-field gel electrophoresis; fingerprinting of penicillin binding protein (pbp) genes; and BOX PCR. Results show that six PFGE patterns (three patterns comprising > or = 2 serotypes) were found widespread and accounted for 64 of the 100 PRSP strains.
Davies
T
T
Department of Pathology, Hershey Medical Center, PA 17033, USA.
Goering
R V
RV
Lovgren
M
M
Talbot
J A
JA
Jacobs
M R
MR
Appelbaum
P C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001208:Asia / Q000453:epidemiology; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics; D016172:DNA Fingerprinting; D016521:Electrophoresis, Gel, Pulsed-Field; D005060:Europe / Q000453:epidemiology; D005798:Genes, Bacterial; D006602:Hexosyltransferases; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D002267:Muramoylpentapeptide Carboxypeptidase / Q000235:genetics; D009656:North America / Q000453:epidemiology; D010403:Penicillin Resistance; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase