title: In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum.
abstract: The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.
authors.affiliation: Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Laboratoire Associé Francophone 302, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon. oceac@camnet.cm
authors.forename: P
authors.initials: P
authors.lastname: Ringwald
authors.forename: E C
authors.initials: EC
authors.lastname: Eboumbou
authors.forename: J
authors.initials: J
authors.lastname: Bickii
authors.forename: L K
authors.initials: LK
authors.lastname: Basco
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004338:Drug Combinations; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D009287:Naphthyridines; C027871:pyronaridine