title: Patient outcome after endovascular treatment of intracranial aneurysms with reference to microsurgical clipping.
abstract: OBJECTIVE
  Endovascular treatment of intracranial aneurysms with Guglielmi detachable coils (GDC) has found growing acceptance worldwide, and partially replaced conventional microsurgery. In this study clinical and angiographical results of embolization are reviewed. In addition, long-term neuropsychological patient outcome with reference to surgery is assessed. Indications for screening and follow-up of the patients as limitations and recent achievements of aneurysm embolization are discussed.
  
  
  METHODS
  Angiographical and clinical follow-up of the first 44 patients with 48 GDC-coiled aneurysms are reviewed. Postprocedural clinical, emotional and social (CES) outcome on disability scale as scored from postal questionnaire data is presented and compared to 106 currently operated patients.
  
  
  RESULTS
  In 75% of the embolized aneurysms successful occlusion was achieved, procedural mortality was 2.3% and morbidity 18.2%. Clinical status of all 15 patients with unruptured aneurysms preserved. Of the surviving 29 patients with ruptured aneurysms 12 improved and the rest preserved their clinical status. In 91% of the embolized patients and in 85% of the operated patients CES outcome was categorized as good or excellent. The difference was statistically nonsignificant.
  
  
  CONCLUSIONS
  Embolization with GDC is a feasible, effective and safe mini-invasive method in small aneurysms with a small neck. However, intentional parent artery occlusion, novel endovascular techniques and embolic agents or supplementary surgery may be necessary in selected cases. Neuropsychological long-term outcome of the patients treated for an intracranial aneurysm does not differ much between GDC embolization and microsurgical clipping.
authors.affiliation: Department of Radiology, Tampere University Hospital, Finland.
authors.forename: V J
authors.initials: VJ
authors.lastname: Kähärä
authors.forename: S K
authors.initials: SK
authors.lastname: Seppänen
authors.forename: T
authors.initials: T
authors.lastname: Kuurne
authors.forename: E M
authors.initials: EM
authors.lastname: Laasonen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials