New developments in structure determination of pseudoknots.
Recently, several high-resolution structures of-RNA pseudoknots have become available. Here we review the progress in this area. The majority of the structures obtained belong to the classical or H-type pseudoknot family. The most complicated pseudoknot structure elucidated so far is the Hepatitis Delta Virus ribozyme, which forms a nested double pseudoknot. In particular, the structure-function relationships of the H-type pseudoknots involved in translational frameshifting have received much attention. All molecules considered show interesting new structural motifs.
Hilbers
C W
CW
NSR Center for Molecular Structure, Design and Synthesis, University of Nijmegen, The Netherlands. ceesh@sci.kun.nl
Michiels
P J
PJ
Heus
H A
HA
D001483:Base Sequence; D003698:Hepatitis Delta Virus / Q000235:genetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D016337:RNA, Catalytic / Q000737:chemistry; D013329:Structure-Activity Relationship
D016337:RNA, Catalytic; D012313:RNA