[Circulatory function and oxygenation during hemihepatectomy. Dopamine versus dopexamine].
OBJECTIVE
The aim of this study was to compare low dose dopamine and dopexamine with respect to of liver-venous oxygen saturation, oxygen delivery and--demand, liver function tests and cardiocirculatory effects in the reperfusion period during a hemihepatectomy operation with occlusion of the liver hilus.


METHODS
Twenty patients were studied in a randomised, doubleblind setting. They either received 2 micrograms/kg per min dopamine or 0.5 microgram/kg per min dopexamine perioperatively. For monitoring purposes a pulmonary artery and a liver venous catheter were placed. At four different time points hemodynamic parameter were assessed and blood samples were drawn.


RESULTS
Significant changes between groups were found 5 min after opening the liver hilus for the cardiac index and the systemic oxygen delivery, as well as at the end of the operation for pulmonary shunt volume, which had increased more in the dopexamine group. No significant difference between liver venous oxygen saturation and liver function tests was found.


CONCLUSIONS
Until more detailed studies concerning the influence of dopamine on the hepatic-splanchnic region during liver surgery are performed, dopexamine can not be considered superior to dopamine during these operations.
Höltje
M
M
Abteilung I, Zentrum Anästhesiologie, Medizinische Hochschule Hannover.
Mahr
K H
KH
Bornscheuer
A
A
Marx
G
G
Stamme
C
C
Rueckoldt
H
H
Piepenbrock
S
S
D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006498:Hepatectomy; D006801:Humans; D007432:Intraoperative Period; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects*; D011446:Prospective Studies
D018491:Dopamine Agonists; C046318:dopexamine; D004298:Dopamine