Chromosome 19 locus apolipoprotein C-II association with multiple sclerosis.
We have used a PCR based method to analyze allelic frequencies in a (TG)n(AG)m microsatellite marker located in the first intron of the apolipoprotein C-II gene in French MS patients and controls. Samples were collected from 74 MS patients and from 102 controls. The distribution of microsatellite alleles differed between patients and controls (chi 2 = 7.82), showing a significant effect (P < 0.04) with MS due to the increased frequency of the allele 6 and a decrease frequency (P < 0.03) of allele I. Our study confirms that the apolipoprotein C-II region may influence susceptibility to MS.
Zouali
H
H
Centre d'Etude du Polymorphisme Humain, Paris, France.
Faure-Delanef
L
L
Lucotte
G
G
D000483:Alleles; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D017931:DNA Primers; D004276:DNA, Satellite / Q000032:analysis; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*
D053304:Apolipoprotein C-II; D001056:Apolipoproteins C; D017931:DNA Primers; D004276:DNA, Satellite; D005819:Genetic Markers; C050929:apolipoprotein C-II (Toronto)