title: Experimental analysis of gossypol and chloroquine interaction in serum and in liver of rat.
abstract: Interactive effects of gossypol and chloroquine as determined by activities of serum alanine transaminase (ALT), aspartate transaminase (AST) and liver lactate dehydrogenase (LDH), alkaline phosphatase (ALK-pase), glucose-6-phosphatase (G-6-pase) and cholesterol level were investigated in rats. Administration of gossypol for eight weeks, at a concentration of 20 mg per kg body wt. per day with or without chloroquine had no effect on the serum enzymes and glucose-6-phosphatase activities. When chloroquine at a concentration of 5 mg per kg body wt. thrice a week was administered alone, there was a marked decrease in total protein content and ALK-pose activities, while a significant increase in LDH activity was observed. Administration of either gossypol or chloroquine decreased the level of cholesterol. A greater decrease was recorded when both were given together. It is suggested that gossypol can be employed as a male contraceptive among malaria-infected populations.
authors.affiliation: Department of Bio-Chemistry, Obafemi Awolowo University, ILE-IFE, Nigeria.
authors.forename: A C
authors.initials: AC
authors.lastname: Achudume
authors.forename: A Y
authors.initials: AY
authors.lastname: Adepoju
authors.forename: K A
authors.initials: KA
authors.lastname: Abu
authors.forename: I G
authors.initials: IG
authors.lastname: Olanrewaju
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D002738:Chloroquine / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D006072:Gossypol / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D006072:Gossypol