Human platelets exclusively bind oxidized low density lipoprotein showing no specificity for acetylated low density lipoprotein.
The widely studied macrophage scavenger receptor system is known to bind both acetylated low density lipoprotein and oxidized low density lipoprotein. Although only the latter ligand has been shown to occur in vivo, acetylated low density lipoprotein is often used to evaluate the contribution of scavenger receptors to different (patho)physiologic processes, assuming that all existing subtypes of scavenger receptors recognise both lipoproteins. In the present work, we identify human platelets as the first natural cell type to bind oxidized low density lipoprotein without showing specificity for acetylated low density lipoprotein. Consequently, platelets possess exclusive receptor(s) for oxidized low density lipoprotein distinct from the 'classical' scavenger receptor AI/AII. From the data presented in this work, we conclude that the class B scavenger receptor CD36 (GPIV) is responsible for this exclusive oxidized low density lipoprotein binding.
Volf
I
I
Institute of Medical Physiology, Vienna, Austria. ivo.volf@univie.ac.at
Moeslinger
T
T
Cooper
J
J
Schmid
W
W
Koller
E
E
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D018955:CD36 Antigens / Q000378:metabolism; D002460:Cell Line; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000378:metabolism; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism
D018955:CD36 Antigens; D008077:Lipoproteins, LDL; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D011134:Polysaccharides; D017452:Receptors, IgG; C032629:acetyl-LDL; C099252:oxidized low density lipoprotein; C007789:fucoidan