title: Inhibition of human mitochondrial aldehyde dehydrogenase by metabolites of disulfiram and structural characterization of the enzyme adduct by HPLC-tandem mass spectrometry.
authors.affiliation: Department of Pharmacology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Mays
authors.forename: A J
authors.initials: AJ
authors.lastname: Tomlinson
authors.forename: K L
authors.initials: KL
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Lam
authors.forename: J J
authors.initials: JJ
authors.lastname: Lipsky
authors.forename: S
authors.initials: S
authors.lastname: Naylor
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004221:Disulfiram / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans; D013058:Mass Spectrometry; D008928:Mitochondria / Q000201:enzymology*; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D011993:Recombinant Fusion Proteins; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D004221:Disulfiram