title: Comparison of hepatic lesions in veal calves with concentrations of copper, iron and zinc in liver and kidney.
abstract: Veal calf producers in Indiana have reported condemnation of carcasses due to icterus as well as condemnation of livers because of yellow discoloration, hepatomegaly and fibrosis. This study assessed the degree of hepatic injury in affected veal calves and correlated it with copper, iron and zinc concentrations in the liver and kidney. Tissues examined histopathologically were from slaughtered and necropsied veal calves. Hepatic lesions were divided into histopathologic categories of severity (minimal, moderate, marked or severe) based upon the degree of fibrosis, biliary epithelial hyperplasia, and inflammation. Hepatic copper levels decreased as the severity of lesions increased. The clinical observations and morphologic changes suggested initial hepatic damage before 9 w-of-age. The affected calves either died of acute copper toxicosis or survived to develop hepatomegaly, hepatic discoloration and/or fibrosis at the time of slaughter.
authors.affiliation: Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, Indiana, USA.
authors.forename: F R
authors.initials: FR
authors.lastname: Robinson
authors.forename: J M
authors.initials: JM
authors.lastname: Sullivan
authors.forename: D R
authors.initials: DR
authors.lastname: Brelage
authors.forename: R L
authors.initials: RL
authors.lastname: Sommers
authors.forename: R J
authors.initials: RJ
authors.lastname: Everson
mesh_terms: D000367:Age Factors; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D003300:Copper / Q000032:analysis; D007501:Iron / Q000032:analysis; D007668:Kidney / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology / Q000662:veterinary*; D014131:Trace Elements / Q000032:analysis*; D015032:Zinc / Q000032:analysis
chemical_list: D014131:Trace Elements; D003300:Copper; D007501:Iron; D015032:Zinc