Hemodynamic effects of new intra-aortic balloon counterpulsation timing methods in patients: a multicenter evaluation.
BACKGROUND
To test whether later intra-aortic balloon pump (IABP) deflation approaching or simultaneous with left ventricular ejection would improve hemodynamics and myocardial efficiency with the use of new balloon deflation methods, 4 IABP timing techniques were evaluated in 43 patients.


RESULTS
Later balloon deflation produced significantly greater percentage changes in mean aortic pressure (6% vs 1%), systolic pressure time index (-27% vs -20%), diastolic pressure time index (35% vs 19%), and the systolic pressure-time index/diastolic pressure-time index ratio (97% vs 51%), respectively. However, these changes increased peak systolic pressure (-15% vs -11%). Cardiac output and stroke volume indexes were not significantly altered over the 4 settings.


CONCLUSIONS
These data suggest that systemic hemodynamics and myocardial efficiency may be improved by later balloon deflation approaching left ventricular ejection in comparison to conventional IABP timing.
Kern
M J
MJ
Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA.
Aguirre
F V
FV
Caracciolo
E A
EA
Bach
R G
RG
Donohue
T J
TJ
Lasorda
D
D
Ohman
E M
EM
Schnitzler
R N
RN
King
D L
DL
Ohley
W J
WJ
Grayzel
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D004452:Echocardiography / Q000379:methods / Q000706:statistics & numerical data; D015150:Echocardiography, Doppler / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014481:United States