title: Synthesis of novel analogues of the delta opioid ligand SNC-80 using AlCl3-promoted aminolysis.
abstract: Two focused libraries of delta opioid ligands were synthesised using AlCl3 facilitated aminolysis. Several compounds were identified with DOR binding affinities higher or similar to SNC-80. A novel acyclic derivative of SNC-80 produced antinociception in the acetic acid abdominal constriction test, which is at least partially mediated via the delta-opioid receptor.
authors.affiliation: Organon Laboratories Ltd., Newhouse, Scotland, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Barn
authors.forename: A
authors.initials: A
authors.lastname: Bom
authors.forename: J
authors.initials: J
authors.lastname: Cottney
authors.forename: W L
authors.initials: WL
authors.lastname: Caulfield
authors.forename: J R
authors.initials: JR
authors.lastname: Morphy
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis*; D002712:Chlorides / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis*; D017465:Receptors, Opioid, delta / Q000737:chemistry*
chemical_list: D017607:Aluminum Compounds; D001549:Benzamides; D002712:Chlorides; D010879:Piperazines; D017465:Receptors, Opioid, delta; C088464:4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide; D000077410:Aluminum Chloride