title: Advances in structural genomics.
abstract: New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome sequences.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK. sat@mrc-lmb.cam.ac.uk
authors.forename: S A
authors.initials: SA
authors.lastname: Teichmann
authors.forename: C
authors.initials: C
authors.lastname: Chothia
authors.forename: M
authors.initials: M
authors.lastname: Gerstein
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends*; D016678:Genome; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*
chemical_list: D011506:Proteins