Pharmacokinetics and inflammatory-fluid penetration of moxifloxacin following oral or intravenous administration.
A single 400-mg oral or intravenous (i.v.) dose of moxifloxacin was given to each of eight healthy male volunteers, and 6 weeks later the dose was administered by the other route. The concentrations of the drug in plasma, cantharidin-induced inflammatory fluid, and urine were measured over the subsequent 24 h. The mean maximum concentrations observed in plasma were 4.98 microg/ml after oral dosing and 5.09 microg/ml after i.v. dosing. The mean maximum concentrations attained in the inflammatory fluid were 2.62 and 3.23 microg/ml, respectively. The mean elimination half-lives from plasma were 8.32 and 8.17 h, respectively. The overall penetration into the inflammatory fluid was 103.4 and 104.2%. Over 24 h 15% of the drug was recovered in the urine when administered by either route.
Wise
R
R
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, United Kingdom. R.Wise@bham.ac.uk
Andrews
J M
JM
Marshall
G
G
Hartman
G
G
D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001372:Aza Compounds; D024841:Fluoroquinolones; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male; D000077266:Moxifloxacin; D011804:Quinolines
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin