Pregnancies in women with Turner's syndrome.
Ovarian failure is a typical feature in Turner's syndrome. Therefore, hormone replacement therapy (HRT) is necessary to achieve the development of normal female sexual characteristics and to prevent cardiovascular complications and osteoporosis. Spontaneous puberty occurs in 5-10% of women with Turner's syndrome, and 2-5% of them become pregnant spontaneously. Sexually active young women with Turner's syndrome need contraception. It can be administered as contraceptive pills, which also serve as HRT. Oocyte donation is now a treatment option for infertility of these women. Excellent results have been obtained with 46% of embryo transfers resulting in pregnancy. The pregnancies carry high risks and have to be followed up carefully. The children born following oocyte donation have no additional risks. Risks can be reduced by transferring only one embryo at a time to the uterus, thus avoiding twin pregnancies. Ovarian tissue from young girls with Turner's syndrome could be cryopreserved for infertility treatment in the future, but the optimal age of ovarian biopsy has to be studied, and methods of replantation and maturation of oocytes in vitro have still to be developed. Fertility counselling has become important in the treatment of girls with Turner's syndrome.
Hovatta
O
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Department of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Sweden. outi.hovatta@obgyn.hs.sll.se
D003278:Contraceptives, Oral, Hormonal; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D018587:Oocyte Donation; D006080:Ovarian Follicle / Q000637:transplantation; D011247:Pregnancy; D011248:Pregnancy Complications; D014424:Turner Syndrome / Q000150:complications*
D003278:Contraceptives, Oral, Hormonal