title: Electroconvulsive treatment of a bipolar adolescent postcraniotomy for brain stem astrocytoma.
abstract: This is the first reported use of electroconvulsive treatment (ECT) in an adolescent with bipolar mania who had been treated with craniectomy for an intracranial neoplasm. The reported case is of a 16-year-old girl with a history of brain stem glioma (pontomesencephalic astrocytoma) diagnosed at 13 years of age. She presented in a psychiatric emergency room with suicidal ideation, depressed mood, irritability, olfactory hallucinations, early insomnia, grandiosity, and guilt. Her symptoms failed to respond to a trial of an antidepressant, mood stabilizer alone, and mood stabilizer in conjunction with a neuroleptic. The decision to use ECT was based on suicidal ideation, extreme disinhibition, and danger to self and others. Significant improvement in mood and remission in psychosis were noted after the eighth treatment. Comparison of 2-week pre-ECT and 3-month post-ECT cognitive testing revealed no change in IQ. This report highlights rapid response and the ability to tolerate ECT in an adolescent diagnosed with bipolar disorder, who had also been treated with radiation and craniotomy.
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor 48109, USA.
authors.forename: N
authors.initials: N
authors.lastname: Ghaziuddin
authors.forename: J R
authors.initials: JR
authors.lastname: DeQuardo
authors.forename: M
authors.initials: M
authors.lastname: Ghaziuddin
authors.forename: C A
authors.initials: CA
authors.lastname: King
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000473:pathology / Q000601:surgery*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D001933:Brain Stem; D003071:Cognition; D003399:Craniotomy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011183:Postoperative Complications / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D016896:Treatment Outcome