title: Effects of cimetidine on broiler fattening and on stress-induced gizzard erosion in chicken.
abstract: The work describes the effects of cimetidine on stress-induced gizzard erosions (Experiment A) and the influence of the long-term application (42 days) of the same drug on weight gain and feed consumption during broiler fattening (Experiment B). For Experiment A, 60 male, three-day-old chicks were divided into two groups: C (n = 30)--control chicks treated with 0.5 ml saline; CIM (n = 30)--chicks treated with cimetidine in a dose of 5 mg/kg body weight (b. w.) intragastrically. All chicks were stressed using a modified water-immersion stress method according to which the chicks, after 24 h of feed deprivation, were immersed in tap water (17 degrees C) for a few seconds. Under chloroform anaesthesia ten chicks from each group were killed 1, 2 and 3 h after the stressing. The morphometric analysis of gizzard erosion (GE) and histopathological examinations of gizzards were performed for each chick. In Experiment B, 32 one-day-old broilers of both sexes were used. The control group was untreated (n = 16) while the CIM group (n = 16) was fed the same diet supplemented with 10 mg of cimetidine per kilogram of feed throughout the fattening period (42 days). The results of Experiment A showed decreased mean length of the GE in the cimetidine-treated birds as compared with the GE lesions of the controls. In Experiment B, the treated chicks had reduced liveweight (1835.1 g), carcass weight (1474.6 g) and increased feed consumption (2115 g of feed per kilogram of weight gain) compared to the controls in which the same parameters were 1898.5 g, 1574.2 g and 1797 g, respectively. The results show that while stress-induced GE of chicks can be medicated pharmacologically, long-term application of the same substance impairs the results of fattening.
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Republic of Croatia. zgrabar@vef.hr
authors.forename: Z
authors.initials: Z
authors.lastname: Grabarević
authors.forename: P
authors.initials: P
authors.lastname: Dzaja
authors.forename: J
authors.initials: J
authors.lastname: Perić
authors.forename: V
authors.initials: V
authors.lastname: Serman
authors.forename: Z
authors.initials: Z
authors.lastname: Bidin
authors.forename: H
authors.initials: H
authors.lastname: Mazija
authors.forename: N
authors.initials: N
authors.lastname: Mas
authors.forename: Z
authors.initials: Z
authors.lastname: Mikulec
authors.forename: K
authors.initials: K
authors.lastname: Culjak
authors.forename: Z
authors.initials: Z
authors.lastname: Simec
authors.forename: B
authors.initials: B
authors.lastname: Njari
mesh_terms: D000818:Animals; D001835:Body Weight; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens / Q000254:growth & development*; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D005895:Gizzard, Avian / Q000187:drug effects / Q000473:pathology*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D011201:Poultry Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D013154:Spleen / Q000473:pathology; D013272:Stomach Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D013312:Stress, Physiological / Q000150:complications / Q000378:metabolism / Q000662:veterinary*; D015430:Weight Gain
chemical_list: D006635:Histamine H2 Antagonists; D002927:Cimetidine