Functional MRI of the human brain with GRASE-based BOLD contrast.
The application of T2*-weighted gradient and spin-echo (GRASE) imaging was investigated as a method for blood oxygenation level-dependent (BOLD)-based functional magnetic resonance imaging (fMRI). The displaced-echo method was implemented to produce single-shot T2*-weighted GRASE images. This technique removes the requirement that the Carr-Purcell Meiboom-Gill (CPMG) condition be fulfilled. T2*-weighted GRASE images that are free from interference artifacts can thus be obtained, hence allowing the possibility of using single-shot GRASE for BOLD-based functional imaging. The method was demonstrated at 3 T and gave robust and reproducible activation-induced signal changes.
Jovicich
J
J
Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany.
Norris
D G
DG
D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003287:Contrast Media; D017352:Echo-Planar Imaging; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D015203:Reproducibility of Results; D014793:Visual Cortex / Q000502:physiology
D003287:Contrast Media; D010100:Oxygen