title: [Usefulness of a pharmacokinetic approach for clinical antineoplastic chemotherapy evaluation].
abstract: Pharmacokinetics, which is the study of the drug becoming in the body, is an important approach of new drug evaluation. Anticancer drugs have mostly a very narrow therapeutic index which leads to a delicate clinical use. Pharmacokinetics permits the prediction of the occurrence of iatrogenic toxicities taking into account the interpatient variability of the pharmacokinetic parameters.
authors.affiliation: Service de pharmacologie clinique, Centre René-Huguenin, 35, rue Dailly, 92210 Saint-Cloud.
authors.forename: F
authors.initials: F
authors.lastname: Lokiec
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000506:poisoning; D019540:Area Under Curve; D002166:Camptothecin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D000077146:Irinotecan; D008657:Metabolic Clearance Rate
chemical_list: D000970:Antineoplastic Agents; D000077146:Irinotecan; D002166:Camptothecin