The effect of low and moderate fat intakes on the postprandial lipaemic and hormonal responses in healthy volunteers.
Present literature indicates that whereas an acute fat intake of 5 g does not elicit a postprandial triacylglycerolaemic response, 20 g of fat does. Since 67% of fat intake occasions involve fat doses of less than 20 g, the present study examined the effect of a relatively low-fat (LF) meal (0.2 g/kg body weight; mean 14 g) on postprandial triacylglycerol (TAG) metabolism, compared with a high-fat (HF) meal (0.6 g/kg body weight; mean 43 g), a fat dose which is more typical of laboratory studies. Plasma- and chylomicron-TAG concentrations increased significantly (P < or = 0.001) following both meals, and the increase was significantly (P < or = 0.02) greater after the HF meal. The postprandial areas under the curves and maximal postprandial TAG concentrations for plasma- and chylomicron-TAG were significantly higher following the HF meal (P < or = 0.05). Postprandial plasma insulin and gastric inhibitory polypeptide concentrations increased significantly (P < or = 0.001) after each meal, but there was no difference between the two meals. These data show that modest amounts of fat in a meal will elicit a measurable postprandial TAG response. Since postprandial lipaemia affects the composition and concentration of the TAG- and cholesterol-rich lipoproteins, controlling dietary TAG supply may influence the metabolic fate of these lipoproteins.
Shishehbor
F
F
Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Republic of Ireland.
Roche
H M
HM
Gibney
M J
MJ
D000328:Adult; D000704:Analysis of Variance; D019540:Area Under Curve; D002914:Chylomicrons / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D019518:Postprandial Period; D012044:Regression Analysis; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D002914:Chylomicrons; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides; D005749:Gastric Inhibitory Polypeptide