Sarcoma botryoides of the cervix. Report of a case with cytopathologic findings.
BACKGROUND
Cytologic findings of sarcoma botryoides were still equivocal because sarcoma botryoides of the uterine cervix is an extremely rare neoplasm, and few cases have been reported to date.


METHODS
A 17-year-old female was diagnosed with sarcoma botryoides of the uterine cervix. The entire vaginal canal was occupied with polypoid masses, which arose from the anterior lip of the uterine cervix, and the tumor was classified as group I (Intergroup Rhabdomyosarcoma Study). After wedge resection and six courses of combination chemotherapy, the tumor recurred in the same location of the cervix as the primary lesion. Touch smear of the polypoid mass formed loose clusters and also showed short spindle cells in a necrotic background. The nucleus of the tumor cells had a thin nuclear membrane, fine chromatin pattern and partly clear nucleolus, showing mild nuclear atypia. Immunohistochemically, some of the tumor cells showed positive staining for myoglobin and desmin.


CONCLUSIONS
The cytologic findings of sarcoma botryoides of the female genital tract are typical features of nonepithelial malignant tumor. Immunohistochemical study is useful for the diagnosis of rhabdomyosarcoma.
Matsuura
Y
Y
Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kashimura
M
M
Hatanaka
K
K
Toki
N
N
Sugihara
K
K
D000293:Adolescent; D015415:Biomarkers; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D018233:Rhabdomyosarcoma, Embryonal / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure
D015415:Biomarkers