title: Chemical shift artifact-free microscopy: spectroscopic microimaging of the human skin.
abstract: A spectroscopic imaging technique with high spatial resolution was used for the study of human skin in vivo. The measurements were performed using a whole-body magnetic resonance system (1.5 T) with standard gradients and a standard 8-cm diameter circular surface coil. A decisive gain in signal-to-noise ratio was achieved by reducing the receiver bandwidth of the imaging system to values less than +/-5 kHz. The chemical shift misregistration was eliminated by post-detection data processing. The method was tested on different kinds of skin, on the foot sole and head. Water, fat, and chemical shift artifact-free images were obtained with resolution 0.107 x 0.143 mm in plane and slice thickness 1 mm. A major advantage of the spectroscopic imaging procedure is that the pulse sequence can be optimized for the maximum signal-to-noise ratio. There is no need for special modification of the sequence to circumvent the chemical shift artifacts (water, fat suppression, etc.).
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden. jan.weis@radiol.uu.se
authors.forename: J
authors.initials: J
authors.lastname: Weis
authors.forename: A
authors.initials: A
authors.lastname: Ericsson
authors.forename: A
authors.initials: A
authors.lastname: Hemmingsson
mesh_terms: D000273:Adipose Tissue; D000465:Algorithms; D016477:Artifacts; D001834:Body Water; D020405:Dermis / Q000033:anatomy & histology; D004817:Epidermis / Q000033:anatomy & histology; D006257:Head / Q000033:anatomy & histology; D006365:Heel / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008853:Microscopy / Q000379:methods*; D012815:Signal Processing, Computer-Assisted; D012867:Skin / Q000033:anatomy & histology*