Decrease in spontaneous motor activity and in brain lipid peroxidation in manganese and melatonin treated mice.
In the present study, we have evaluated whether melatonin (MEL) modulates Mn-induced decrease in spontaneous motor activity (SMA) and lipid peroxidation, estimated as malondialdehyde (MDA) formation, in several brain regions. In mice treated with manganese a decrease in SMA after 2 weeks of treatment was observed. In the group treated with Mn+MEL a significant greater reduction in SMA was detected at 4 weeks. MDA levels were reduced in both MEL and Mn treated mice. In the animals treated with MEL + Mn a higher reduction in MDA levels was observed. These results suggest that MEL modulates the effect of Mn on SMA and brain lipid peroxidation.
Talavera
E J
EJ
Department of Neurobiology, Instituto de Investigaciones Biomedicas, Fundacite-Zulia, Maracaibo, Venezuela.
Arcaya
J L
JL
Giraldoth
D
D
Suárez
J
J
Bonilla
E
E
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004347:Drug Interactions; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008345:Manganese / Q000008:administration & dosage / Q000494:pharmacology*; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D008345:Manganese; D008315:Malondialdehyde; D008550:Melatonin