title: Lentigo maligna and malignant melanoma in situ, lentigo maligna type.
abstract: Some authors have considered lentigo maligna to be an atypical melanocytic proliferation, whereas others have considered it to be melanoma in situ. We reviewed 50 cases of lentigo maligna. We have identified two subsets of lesions. The first has atypical melanocytic hyperplasia, which we postulate to be correctly designated lentigo maligna. The second subset has the following features in addition to the melanocytic hyperplasia: individual and nests of cells at varying layers of the epidermis, confluence of the melanocytes replacing the basilar region, uniformity of the cytological atypia, and nesting of uniformly atypical melanocytes. These lesions we designate as malignant melanoma in situ, lentigo maligna type. We are proposing that the lesions that have been termed lentigo maligna represent a spectrum of atypia and that the application of some of the traditional features for the diagnosis melanoma may permit the segregation of more and less aggressive lesions.
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Flotte
authors.forename: M C
authors.initials: MC
authors.lastname: Mihm
mesh_terms: D000368:Aged; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000145:classification* / Q000473:pathology*; D006965:Hyperplasia; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000145:classification* / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*