title: Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish.
abstract: Bone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nikaido
authors.forename: M
authors.initials: M
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Ueno
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D052005:Bone Morphogenetic Protein Receptors, Type I; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000201:enzymology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017978:Receptors, Growth Factor / Q000235:genetics*; D019170:Somites / Q000201:enzymology; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*
chemical_list: D017978:Receptors, Growth Factor; D017346:Protein Serine-Threonine Kinases; C498214:BMPR1B protein, human; D052005:Bone Morphogenetic Protein Receptors, Type I