The interaction of sarin and soman with plasma proteins: the identification of a novel phosphonylation site.
Incubation of both sarin and soman with human plasma has shown that binding occurs to a tyrosine residue. Similar binding occurs when sarin and soman are incubated with human serum albumin. This binding may provide an important biological marker, which retains full structural information concerning the identity of the agent, in cases of allegations of chemical warfare use.
Black
R M
RM
DERA, CBD Porton Down, Salisbury, Wilts, UK.
Harrison
J M
JM
Read
R W
RW
D015415:Biomarkers; D002619:Chemical Warfare Agents / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D012524:Sarin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D012999:Soman / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D015415:Biomarkers; D002619:Chemical Warfare Agents; D012709:Serum Albumin; D014443:Tyrosine; D012999:Soman; D012524:Sarin