title: Mutagenic activity of 3,6-diamino-10-methyl-9,10-dihydroacridine in Salmonella typhimurium cells.
abstract: Mutagenic evaluation of 3,6-diamino-10-methyl-9,10-dihydroacridine (AcrH), a new synthesized acridine derivative was undertaken using short-term in vitro test. The mutagenic potential of AcrH was evident from the reverse mutation induced in the presence and absence of S9-mix of Salmonella typhimurium TA97a, TA98, TA100 and TA102 cells. The levels of the mutagenic activity of AcrH in TA97a are comparable with that of acriflavine.
authors.affiliation: Department of Biology and Medical Genetics, Military Medical Academy, Lódź, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Ferenc
authors.forename: E
authors.initials: E
authors.lastname: Janik-Spiechowicz
authors.forename: W
authors.initials: W
authors.lastname: Bratkowska
authors.forename: A
authors.initials: A
authors.lastname: Denys
mesh_terms: D000166:Acridines; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
chemical_list: D000166:Acridines; D009153:Mutagens