Review: infectious diseases and coagulation disorders.
Infection, both bacterial and nonbacterial, may be associated with coagulation disorders, resulting in disseminated intravascular coagulation and multiorgan failure. In the last few decades a series of in vivo and in vitro studies has provided more insight into the pathogenetic mechanisms and the role of cytokines in these processes. Because of the growing interest in this field, the complexity of the subject, and the fact that many physicians must deal with a variety of infections, current data are reviewed on the association between infectious diseases and the coagulation system. Novel therapeutic intervention strategies that will probably become available in the near future are mentioned, along with those of special interest for infectious disorders for which only supportive care can be given.
van Gorp
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EC
Slotervaart Hospital, Department of Internal Medicine/Infectious Diseases, 1066 EC Amsterdam, The Netherlands. Igego@slv.nl
Suharti
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ten Cate
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Dolmans
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WM
van der Meer
J W
JW
ten Cate
J W
JW
Brandjes
D P
DP
D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000150:complications*; D003141:Communicable Diseases / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D006463:Hemolytic-Uremic Syndrome / Q000150:complications; D006801:Humans; D008954:Models, Biological; D009102:Multiple Organ Failure / Q000209:etiology; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications; D013927:Thrombosis / Q000150:complications