[Interferon incorporated into liposomes. A method for the design of homologous and heterologous liposomes and the control of their in-vivo permeability].
The specific features of the fatty acid composition of phospholipid carriers obtained from raw materials of vegetable and animal origin were studied. Differences in the enrichment of phospholipids of different origin with polyene fatty acids were shown. The method for obtaining fluoroliposomes incorporating such components as phospholipids of mouse organs, egg yolk, etc. were proposed. The study proved that the homology of the lipid base of liposomes facilitated their binding by tropic organs and more rapid liberation of the blood stream from them. The selection of lipid carriers and their sources was determined by their uniformity, morpho-functional importance, phospholipid and fatty acid composition, as well as their homology as regards their composition features.
Kalenik
T K
TK
Far Eastern Academy of Economy and Management, State University, Vladivostok, Russia.
Motavkina
N S
NS
Vorob'ev
A A
AA
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D004337:Drug Carriers; D015195:Drug Design; D004530:Egg Yolk; D005227:Fatty Acids / Q000032:analysis; D007372:Interferons / Q000008:administration & dosage*; D008081:Liposomes; D051379:Mice; D010539:Permeability; D010743:Phospholipids / Q000032:analysis; D046048:Seals, Earless; D013050:Spectrometry, Fluorescence / Q000379:methods
D004337:Drug Carriers; D005227:Fatty Acids; D008081:Liposomes; D010743:Phospholipids; D007372:Interferons