title: Plexiform fibrohistiocytic tumor of the foot.
abstract: The first case of plexiform fibrohistiocytic tumor in the foot is presented in this article. The tumor developed on the dorsum of the left foot in a 14-year-old female. This tumor was originally described in 1988 by Enzinger and Zhang. Their study indicated that this tumor has a female predominance, median age of 14.5 years, 63% located in the upper extremities, 37.5% recurrence rate, and 3% metastasis rate. These tumors are very unique with a nodular pattern and a cellular component of histiocytes, fibroblasts, and multinucleated giant cells. Typically they are located within the deep dermis and subcutaneous tissue. Immunohistochemical preparations show that the tumor does not stain for S-100 protein, desmin, cytokeratin, factor VIII-related protein, or lysozyme. However, it does stain for alpha-1-antitrypsin, alpha-1-antichymotrypsin, alpha-smooth muscle-specific actin, vimentin, and CD68 antibody.
authors.affiliation: Riverside Mercy Hospital, Toledo, OH 43604, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Wilkin
authors.forename: J W
authors.initials: JW
authors.lastname: Lane
mesh_terms: D000293:Adolescent; D005260:Female; D005534:Foot Diseases / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans