[Importance of estimated value of T-cell activation in insulin-dependent diabetes mellitus].
OBJECTIVE
To determine the role of estimated value HLA-DR+/CD19+ in patients with insulin-dependent diabetes mellitus (IDDM) in the course of the disease.


METHODS
The number of CD+ and HLA-DR+ lymphocytes and the ratio HLA-DR+/ CD19+ were estimated in the peripheral blood of 70 IDDM patients aged 9-47 years with the disease duration since the diagnosis 0-10. Indirect immunofluorescence with monoclonal antibodies was employed.


RESULTS
The index HLA-DR+/CD19+ was normal in newly-diagnosed IDDM patients and tended to an increase with the disease aggravation.


CONCLUSIONS
The index HLA-DR+/CD19+ can be used as an additional marker of T-lymphocyte activation, as a criterium of unfavorable IDDM course.
Zhuk
E A
EA
Galenok
V A
VA
D000293:Adolescent; D000328:Adult; D018941:Antigens, CD19 / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
D018941:Antigens, CD19; D015415:Biomarkers; D006684:HLA-DR Antigens