[The role of beta1 integrins in renal failure accompanied by multiple myeloma].
Clinical features of multiple myeloma are linked with immunological phenotype of myeloma cells. The interactions between malignant plasma cells and proteins of ECM (extracellular matrix) or different cells results from the influence of adhesion molecules. In our study the expression of CD49b, CD49d, CD49e, CD49f on the myeloma cells has been estimated. These cells were obtained from bone marrow of 33 just diagnosed patients. Immunophenotyping was performed with flow cytometry method. Malignant plasma cells were identified by monoclonal antibody anti-CD138 (B-B4) directed against Syndecan-1. We have observed that in patients with high expression of laminin receptors CD49b, CD49f and lack of fibronectin receptors CD49d, CD49e more often renal failure has been confirmed.
Jawniak
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Katedra i Klinika Hematologii Akademii Medycznej w Lublinie.
Dmoszyńska
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Goracy
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D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D019012:Integrin beta1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D017469:Receptors, Fibronectin / Q000032:analysis; D017474:Receptors, Laminin / Q000032:analysis
D019012:Integrin beta1; D017469:Receptors, Fibronectin; D017474:Receptors, Laminin