IAPP as a regulator of glucose homeostasis and pancreatic hormone secretion (review).
IAPP is a 37-amino acid peptide that is predominantly expressed in pancreatic beta cells. Despite co-secretion from islets the relative amounts of IAPP and insulin may vary. Since IAPP was first described as the major peptide constituent of amyloid in the islets of Langerhans of subjects with type 2 diabetes and insulinoma, many studies have been devoted to investigating the role of IAPP in formation of amyloid deposits and in diabetes pathogenesis. However, there is growing evidence for IAPP as an active islet hormone in addition to insulin and glucagon in glucose metabolic control. An inhibitory effect is seen by IAPP on gastric emptying, glycogen synthesis in skeletal muscle, islet insulin and glucagon secretion, whereas a stimulatory effect is seen on hepatic gluconeogenesis.
Karlsson
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Department of Medical Cell Biology, Uppsala University, Biomedicum, SE-751 23 Uppsala, Sweden.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D058228:Islet Amyloid Polypeptide; D008969:Molecular Sequence Data; D009765:Obesity / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000378:metabolism*; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000378:metabolism; D014018:Tissue Distribution
D000682:Amyloid; D058228:Islet Amyloid Polypeptide; D010187:Pancreatic Hormones; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide; D005947:Glucose