Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography.
We describe a protocol to manufacture 82Sr/82Rb generators and 82RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82Sr. The generators produced sterile and non-pyrogenic 82RbCl for i.v. injection. No significant 82Sr/85Sr breakthroughs were observed after elution with 20 1 of saline. The automated system delivered human doses of 82RbCl accurately.
Alvarez-Diez
T M
TM
Nuclear Medicine Division, Ottawa Civic Hospital, Ont., Canada. teresa.ad@sympatico.ca
deKemp
R
R
Beanlands
R
R
Vincent
J
J
D002712:Chlorides / Q000592:standards* / Q000627:therapeutic use; D003327:Coronary Disease / Q000000981:diagnostic imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D011786:Quality Control; D011835:Radiation Protection; D011876:Radionuclide Generators; D012413:Rubidium / Q000592:standards* / Q000627:therapeutic use; D012414:Rubidium Radioisotopes; D013326:Strontium Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods
D002712:Chlorides; D012414:Rubidium Radioisotopes; D013326:Strontium Radioisotopes; D012413:Rubidium; C032710:rubidium chloride