Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans.
Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycoplasma fermentans were demonstrated to trigger the transcription of intercellular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gingival tissue and to induce its cell surface expression by a mechanism distinct from that of Escherichia coli lipopolysaccharide. The lipid moiety of the lipoproteins was suggested to play a key role in the expression of the activity.
Dong
L
L
Departments of Oral Bacteriology, Hokkaido University School of Dentistry, Kita-Ku, Sapporo 060-8586, Japan.
Shibata
K
K
Sawa
Y
Y
Hasebe
A
A
Yamaoka
Y
Y
Yoshida
S
S
Watanabe
T
T
D001426:Bacterial Proteins / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D005881:Gingiva / Q000166:cytology / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000235:genetics*; D008074:Lipoproteins / Q000378:metabolism; D009174:Mycoplasma / Q000502:physiology*; D016858:Mycoplasma fermentans / Q000502:physiology*; D012333:RNA, Messenger; D015533:Transcriptional Activation; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics
D001426:Bacterial Proteins; D008074:Lipoproteins; D012333:RNA, Messenger; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1