[The effect of clofelin on the transudation of plasma proteins into the dura mater induced by stimulation of the trigeminal ganglion].
Intravenous administration of clofelin blocks transudation of 131I-albumin into the dura mater of rats in electrical stimulation of the trigeminal ganglion. Preliminary injection of the alpha-adrenoblocker yohimbine and the antagonist of serotonin receptors 5-NT1 mianserin completely removes the blocking effect of clofelin. Naloxon and the alpha 1-adrenoblocker prazosin had no effect on the degree of expression of albumin transudation and the clophelin effect. The role of the adrenergic system, the presynaptic alpha 2-adrenoceptors in particular, in functioning of the trigeminovascular system and the development of neurogenic inflammation in the dura mater is discussed.
Amelin
A V
AV
Valdman Institute of Pharmacology, St. Petersburg State Medical University, Russia.
Ivanov
V E
VE
Usachev
N I
NI
Pushkarev
A A
AA
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004388:Dura Mater / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D005122:Exudates and Transudates / Q000187:drug effects* / Q000502:physiology; D007457:Iodine Radioisotopes; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000187:drug effects*; D012668:Trigeminal Ganglion / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D007457:Iodine Radioisotopes; D012709:Serum Albumin; D003000:Clonidine