Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro.
The effects of eight kinds of Chinese medicinal herbs (CMH) on human lymphocytes was studied in vitro. The extract of Cinnamomum cassia presl markedly stimulated human lymphocytes to proliferate. Codonopsis pilosula, Oldenlandia diffusa and Rhizoma typhonii weakly stimulated. These extracts enhanced cytotoxic T-lymphocyte (CTL) activity, but failed to enhance natural killer (NK)-cell activity. The extracts of these CMHs have stimulatory effect on immunoglobulin (Ig) production by B-cells and interleukin(IL)-1 production by monocytes. These activities of Cinnamomun cassia presl extract are associated with glycoproteins, whose molecular weight was about 100 KDa. These results suggest that CMH extracts have a stimulating activity on human lymphocytes and these abilities could be used clinically for the treatment of diseases such as cancer.
Shan
B E
BE
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Yoshida
Y
Y
Sugiura
T
T
Yamashita
U
U
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000097:blood; D007375:Interleukin-1 / Q000096:biosynthesis / Q000097:blood; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D006023:Glycoproteins; D007136:Immunoglobulins; D007375:Interleukin-1; D008934:Mitogens