Technetium-99m complex of N-(2-pyridylmethyl)iminodiacetic acid as a new renal radiopharmaceutical.
A tetradentate chelating agent constituting of an iminodiacetic acid group and a nitrogen atom of pyridine, N-(2-pyridylmethyl)iminodiacetic acid (PMIDA), was coordinated with 99mTc and evaluated as a renal functional agent. The complex of PMIDA with 99mTc was prepared by using a stannous chloride solution as a reducing agent. The chelating efficiency was analyzed by thin layer chromatography and electrophoresis. Chelation with 99mTc resulted in a single radiochemical product. Biological studies were performed in mice and rats. 99mTc-PMIDA was removed from the circulation solely by the kidneys. Clearance of 99mTc-PMIDA from the blood and the kidneys was as rapid as that of 99mTc-diethylenetriaminepentaacetic acid. The rate of blood clearance was unaffected by the administration of probenecid (a test for tubular secretion by the weak-acid mechanism), so that the glomerular filtration rate could be estimated by measuring its clearance from the blood. The results in animals with myohemoglobinuric acute renal failure suggested that 99mTc-PMIDA might be a useful renal function radiopharmaceutical.
Karube
Y
Y
Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. karube@fukuoka-u.ac.jp
Iwamoto
K
K
Takata
J
J
D058186:Acute Kidney Injury / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D002614:Chelating Agents; D002855:Chromatography, Thin Layer; D004586:Electrophoresis; D005919:Glomerular Filtration Rate; D006877:Hydroxamic Acids; D007098:Imino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D017879:Isothiocyanates; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D008813:Mice, Inbred ICR; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D013667:Technetium / Q000737:chemistry
C100700:6-(4-isothiocyanatobenzyl)-diethylenetriamine pentaacetic acid; D002614:Chelating Agents; D006877:Hydroxamic Acids; D007098:Imino Acids; D017879:Isothiocyanates; C113314:N,N'-propylenebis(benzohydroxamamide); D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C120435:technetium Tc 99m N-(2-pyridylmethyl)iminodiacetic acid; D013667:Technetium; D004369:Pentetic Acid