Mutagenic activity of 3,6-diamino-10-methyl-9,10-dihydroacridine in Salmonella typhimurium cells.
Mutagenic evaluation of 3,6-diamino-10-methyl-9,10-dihydroacridine (AcrH), a new synthesized acridine derivative was undertaken using short-term in vitro test. The mutagenic potential of AcrH was evident from the reverse mutation induced in the presence and absence of S9-mix of Salmonella typhimurium TA97a, TA98, TA100 and TA102 cells. The levels of the mutagenic activity of AcrH in TA97a are comparable with that of acriflavine.
Ferenc
T
T
Department of Biology and Medical Genetics, Military Medical Academy, Lódź, Poland.
Janik-Spiechowicz
E
E
Bratkowska
W
W
Denys
A
A
D000166:Acridines; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D000166:Acridines; D009153:Mutagens