[Effect of hypothermia on lactate acidosis in experimental ischemia of rat brain].
The aim of the work was to evaluate the effect of hypothermia on lactate level in the rat cerebral ischaemia. Adult male Wistar rats were subjected to injection of 0.05 ml of air into the ligation of left common carotid artery. Lactate level increased in cerebral hemispheres after 4 hours following air emboli. Mild hypothermia (28 degrees-31 degrees C) continued for 4 hours of cerebral ischaemia, and its beneficial effect was observed. A statistically significant decrease of lactate concentration was noted. The above phenomenon was confirmed by the increase of cerebral acidosis after 24 hours when mild hypothermia was interrupted from the 4th hour of the experiment on. It seems to be of a great importance to adjust proper time of initiation and a duration of hypothermia in cerebral ischaemia treatment.
Ostrowski
R P
RP
Zakład Neuropatologii, Instytutu Centrum Medycyny Doświadczalnej i Klinicznej PAN w Warszawie.
Piotrowski
P
P
Wierzbicka
K
K
Smiałek
M
M
D000140:Acidosis, Lactic / Q000628:therapy*; D000818:Animals; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000628:therapy*; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors