title: [Concentration of heavy elements and their compounds in the cells from BALF and pulmonary tumors in radiation-exposed subjects].
abstract: OBJECTIVE
  Measurement of heavy elements in alveolar macrophages (AM) of bronchoalveolar lavage (BAL) and pulmonary tumor tissue (PTT); investigation of spacial distribution of the heavy particles in the tissues.
  
  
  METHODS
  Laser mass-spectrometry estimated quantitative and qualitative characteristics of heavy elements (Mn, Fe, Co, Cu, Zr, etc.) in diagnostic and therapeutic BAL of 6 patients exposed to radiation after the Chernobyl accident and in pulmonary tumor tissue of patients operated for central small-cell and peripheral bronchoalveolar cancer who also had been exposed to radiation after the Chernobyl.
  
  
  RESULTS
  Heavy elements concentration in the secondary BAL was less than in the primary one. This shows effectiveness of the procedures aimed at removal of heavy particles from the respiratory organs. Heavy elements content was quite different in two histologically different tumors.
  
  
  CONCLUSIONS
  Laser mass-spectrometry proved its usefulness in simultaneous study of the quantity and quality of heavy elements in AM of BAL and tumors in radiation-exposed subjects, in investigation of the elements distribution in the pulmonary tissues and changes of elements composition in the tissues in the course of tumors development.
authors.forename: A G
authors.initials: AG
authors.lastname: Chuchalin
authors.forename: O A
authors.initials: OA
authors.lastname: Liaskina
authors.forename: P G
authors.initials: PG
authors.lastname: Pleshanov
authors.forename: E P
authors.initials: EP
authors.lastname: Pleshanova
authors.forename: D
authors.initials: D
authors.lastname: Sayers
authors.forename: W
authors.initials: W
authors.lastname: Zhou
authors.forename: K
authors.initials: K
authors.lastname: McHugo
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Bykovskiĭ
authors.forename: V D
authors.initials: VD
authors.lastname: Peklenkov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Koniukhov
authors.forename: D V
authors.initials: DV
authors.lastname: Ponomarenko
authors.forename: S P
authors.initials: SP
authors.lastname: Ammosova
authors.forename: A L
authors.initials: AL
authors.lastname: Cherniaev
authors.forename: O M
authors.initials: OM
authors.lastname: Grobova
authors.forename: A E
authors.initials: AE
authors.lastname: Ali-Riza
authors.forename: B M
authors.initials: BM
authors.lastname: Giller
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000737:chemistry* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D018288:Carcinoma, Small Cell / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D016676:Macrophages, Alveolar / Q000737:chemistry; D019216:Metals, Heavy / Q000032:analysis*; D009381:Neoplasms, Radiation-Induced / Q000737:chemistry* / Q000473:pathology; D009688:Nuclear Reactors; D011210:Power Plants; D018788:Radioactive Hazard Release; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014455:Ukraine
chemical_list: D019216:Metals, Heavy