The effect of carbachol on the phase of free-running locomotor activity rhythm under constant darkness (DD) and constant light (LL) in mice.
Carbachol chronically and peripherally administered, depending on the circadian time, caused a phase shift in the free-running locomotor activity rhythm, resynchronized the rhythm, or had a masking effect of this rhythm in mice. In the discussion it is stressed that the drug affects the rhythmicity of this activity, probably by acting on the mechanism of suprachiasmatic nuclei.
Gaweda
M
M
Department of Animal Physiology, Institute of Zoology, Jagiellonian University, Kraków, Poland. mgaweda@friko7.onet.pl
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D018678:Cholinergic Agents / Q000494:pharmacology*; D002940:Circadian Rhythm; D005260:Female; D008027:Light; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
D018678:Cholinergic Agents; D002217:Carbachol