Ameliorative effect of an urinary preparation on acetaminophen and D-galactosamine induced hepatotoxicity in rats.
The effect of oral administration of a preparation of human urine (PHU) on acute liver injury was examined in rats intoxicated with acetaminophen and D-galactosamine. The results indicated that PHU protected the liver from acetaminophen and D-galactosamine-induced injury as judged by morphological and biochemical observation. An increase in lipid peroxide concentrations and decrease in protein concentrations occurred in the liver by D-galactosamine injection, PHU administration significantly prevented these changes.
Lai
T Y
TY
Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Wu
Y W
YW
Lin
W C
WC
D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005688:Galactosamine / Q000506:poisoning*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014556:Urine
D000082:Acetaminophen; D005688:Galactosamine; D005978:Glutathione