[The distant effects of acetylcholine--links in the pathogenesis of poisoning by cholinesterase inhibitors].
Scanning electron microscopy showed that the capillary endothelial cells of rats poisoned by O,O-dimethyl-O(2,2-dichlorvinyl) phosphate swell and become wrinkled, while some of the cells acquire fenestrae. In 24 h. these changes become weaker. Mass deformity of erythrocytes was seen at the same time and lasted less than 24 h. Since the capillary endothelium and the erythrocytes are devoid of cholinergic innervation but possess cholinoreceptors, the occurring effects may be explained by the distant action of acetylcholine accumulating in the blood in poisoning by cholinestarase inhibitors.
Skopichev
V G
VG
Institute of Physiology, Saint Petersburg University, Russia.
Prozorovskiĭ
V B
VB
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001065:Appendix / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004006:Dichlorvos / Q000506:poisoning*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000648:ultrastructure; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D007306:Insecticides / Q000506:poisoning*; D008855:Microscopy, Electron, Scanning; D011041:Poisoning / Q000097:blood / Q000209:etiology / Q000473:pathology; D051381:Rats; D013499:Surface Properties; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004006:Dichlorvos; D000109:Acetylcholine