Primary antiphospholipid syndrome: a cause of catastrophic shunt thrombosis in the newborn.
This is a unique report of systemic-to-pulmonary artery shunt thromboses secondary to primary antiphospholipid syndrome and antithrombin III deficiency in a neonate with cyanotic congenital heart disease. This infant with tricuspid atresia experienced thromboses of two modified Blalock-Taussig shunts en route to a bidirectional cavo-pulmonary shunt and potential future Fontan operation. Chronic warfarin anticoagulation has prevented additional thrombo-embolic events.
Deally
C
C
Children's Heart Center, Winnipeg, Manitoba, USA.
Hancock
B J
BJ
Giddins
N
N
Hawkins
L
L
Odim
J
J
D016736:Antiphospholipid Syndrome / Q000150:complications*; D020152:Antithrombin III Deficiency / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D011651:Pulmonary Artery / Q000601:surgery; D013927:Thrombosis / Q000209:etiology*; D018785:Tricuspid Atresia / Q000150:complications / Q000601:surgery