Dopaminergic modulation of pallidal preproenkephalin mRNA.
The present study examines dopaminergic regulation of neuropeptide gene expression within a relatively poorly characterized population of cells, the preproenkephalin (PPE) mRNA containing neurons of the globus pallidus (GP). Rats that received 6-hydroxydopamine (6-OHDA) lesions or repeated D1 or D2 antagonist administration were compared to control animals. One month after 6-OHDA lesions, PPE mRNA was elevated in the GP ipsilateral to the lesion, with a smaller elevation also being observed in the contralateral GP. Repeated administration of eticlopride, but not SCH 23390, also resulted in elevated PPE mRNA expression in the GP. These data reveal a novel effect of decreased dopamine transmission on the GP, and draw attention to this subpopulation of pallidal neurons.
Schuller
J J
JJ
Department of Psychobiology University of California, Irvine, CA, 92697-4550, USA.
Billings
L M
LM
Marshall
J F
JF
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004745:Enkephalins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D005917:Globus Pallidus / Q000737:chemistry* / Q000166:cytology / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D016627:Oxidopamine; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012457:Salicylamides / Q000494:pharmacology; D013378:Substantia Nigra / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D013462:Sulfur Radioisotopes; D013565:Sympatholytics
D001552:Benzazepines; D018492:Dopamine Antagonists; D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; D012457:Salicylamides; D013462:Sulfur Radioisotopes; D013565:Sympatholytics; D016627:Oxidopamine; C033660:preproenkephalin; C045989:eticlopride; D004298:Dopamine