Leukemia inhibitory factor, Interleukin 6, and other cytokines using the GP130 transducing receptor: roles in inflammation and injury.
Inflammation refers to a complex set of mechanisms by which tissues respond to injury and infection. Among the many soluble mediators associated with this process, cytokines are known to be crucial in regulating a variety of cellular and molecular events. Leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and possibly other members of this cytokine family are key mediators in various inflammatory processes such as the acute-phase reaction, tissue damage, and infection. These cytokines can act in both pro-inflammatory and anti-inflammatory ways, depending on a number of variables. We emphasize here recent work utilizing knockout mice, which has highlighted the roles of LIF and IL-6, particularly in interactions between the immune and nervous systems.
Gadient
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Novartis Pharma Research, Transplantation and Gene Therapy, Basel, Switzerland.
Patterson
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D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D050822:Cytokine Receptor gp130; D006131:Growth Inhibitors / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D017370:Interleukin-11 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology*; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D014947:Wounds and Injuries / Q000378:metabolism*
D015703:Antigens, CD; D006131:Growth Inhibitors; C494199:IL6ST protein, human; C494200:Il6st protein, mouse; D017370:Interleukin-11; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D008222:Lymphokines; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130