title: Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21.
abstract: Five genes on human chromosome 7 (HSA 7) were assigned to bovine chromosome 21 (BTA 21) and 4 (BTA 4) using a bovine-rodent somatic hybrid cell panel. These five genes were alpha-I subunit of adenylate cyclase-inhibiting G-protein (GNAI1), alpha/beta preprotachykinin (TAC1), reelin (RELN), c-AMP dependant protein kinase type II beta regulatory chain (PRKAR2B) and apolipoprotein A1 regulatory protein 1 (TFCOUP2). Four genes mapped to BTA 4 (GNAI1, TAC1, RELN, PRKAR2B) while one gene mapped to BTA 21 (TFCOUP2). This study confirms the synteny conservation between HSA 7 and BTA 4, finely maps the breakpoints of conserved synteny on HSA 7 and defines a new synteny conservation between HSA 7 and BTA 21.
authors.affiliation: Fort Keogh Livestock and Range Research Laboratory, Miles City, MT 53901, USA. eric@larrl.ars.usda.gov
authors.forename: E
authors.initials: E
authors.lastname: Antoniou
authors.forename: J E
authors.initials: JE
authors.lastname: Womack
authors.forename: M D
authors.initials: MD
authors.lastname: Grosz
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D001483:Base Sequence; D051836:COUP Transcription Factors; D002417:Cattle / Q000235:genetics*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D054757:Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D009419:Nerve Tissue Proteins; D016133:Polymerase Chain Reaction; D011498:Protein Precursors / Q000235:genetics; D011987:Receptors, Steroid; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D013045:Species Specificity; D015320:Tachykinins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D051836:COUP Transcription Factors; D015816:Cell Adhesion Molecules, Neuronal; D054757:Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit; D017931:DNA Primers; D004268:DNA-Binding Proteins; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; C517837:PRKAR2B protein, human; D011498:Protein Precursors; D011987:Receptors, Steroid; D000091042:Reelin Protein; D015320:Tachykinins; D014157:Transcription Factors; C044206:preprotachykinin; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases; C000717127:RELN protein, human; D012697:Serine Endopeptidases; D019204:GTP-Binding Proteins