title: [Leukotriene antagonists].
abstract: Today, medicinal treatment of asthma over the long term is well codified and involves inhaled corticosteroid therapy, in association or not with beta 2-mimetic substances. Numerous studies have demonstrated the importance of leukotrienes in bronchoconstriction and in the delayed inflammatory reaction of asthma. At the same time, antileukotriene molecules are being introduced. Several are sold in different countries. At present, only one product is available in France: Montelukast. It is officially indicated as a complementary treatment of mild to moderate persistent asthma, not sufficiently balanced by inhaled corticosteroid therapy and as a treatment of exercise-induced asthma. In the future, studies should further define the position of these substances in the long term treatment of asthma.
authors.affiliation: Service de Pneumologie, Centre Hospitalier Général de Saint-Nazaire.
authors.forename: J P
authors.initials: JP
authors.lastname: Mallet
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D003521:Cyclopropanes; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D011804:Quinolines / Q000627:therapeutic use; D013440:Sulfides
chemical_list: D000085:Acetates; D000305:Adrenal Cortex Hormones; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast
vernacular_title: Les antileucotriènes.