Integrated pathway-genome databases and their role in drug discovery.
Integrated pathway-genome databases describe the genes and genome of an organism, as well as its predicted pathways, reactions, enzymes and metabolites. In conjunction with visualization and analysis software, these databases provide a framework for improved understanding of microbial physiology and for antimicrobial drug discovery. We describe pathway-based analyses of the genomes of a number of medically relevant microorganisms and a novel software tool that visualizes gene-expression data on a diagram showing the whole metabolic network of the microorganism.
Karp
P D
PD
Pangea Systems, 4040 Campbell Ave, Menlo Park, CA 94025, USA. pkarp@PangeaSystems.com
Krummenacker
M
M
Paley
S
S
Wagg
J
J
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D003628:Database Management Systems; D015195:Drug Design; D016680:Genome, Bacterial; D016681:Genome, Fungal; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D018511:Systems Integration
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents