title: Synthesis and cytotoxicity of aminosterols: activity studies on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6).
abstract: Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.
authors.affiliation: Laboratoire de Synthèse et Etude de Substances Naturelles à Activité's Biologiques, Université de La Rochelle, France.
authors.forename: L
authors.initials: L
authors.lastname: el Kihel
authors.forename: S
authors.initials: S
authors.lastname: Bosch
authors.forename: M
authors.initials: M
authors.lastname: Dherbomez
authors.forename: C
authors.initials: C
authors.lastname: Roussakis
authors.forename: Y
authors.initials: Y
authors.lastname: Letourneux
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001984:Bronchial Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013261:Sterols / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013261:Sterols