[Regularities of corneal tissue correlation and their biological significance for regeneration and pre-tumor growth].
Experimental denervation of the central portions of the cornea in rabbits permitted us to hypothesize "autonomism" of corneal tissues, manifesting as soon as corneal tissues loose connection to the nervous system inhibiting cell growth and division. It involved edema, decreased differentiation, loss of correlation between the epithelium and stroma, submerged growth, and eventually even transformation into a sort of tissue culture in the organism. Experiments demonstrated that increased tissue differentiation is paralleled by in-growth of nerve endings. The degree of differentiation and functional intactness of tissues is maintained by the nervous system. If there are no conditions for reinnervation or the injury (irritation) is repeated, the process transforms into pathological: cords of immature tissue penetrate into the depth of the eye from open edges of corneal and scleral wounds, granulation of chronic wounds is abnormal, and pretumor states of tissues develop. Further status of such tissue apparently depends on new vessels, repeating the transformation of epithelial stroma and connective tissue. Increased growth of the epithelium and stromal elements leads to thickening of vascular wall, dilatation of vascular lumen, and to complete obliteration. Repeated irritation resumes the process of tissue transformation with formation of new vessels. Angiogenesis is apparently related to denervation, and each new irritation induces repeated vascular growth. Treatment and prevention are to be aimed at removal of the irritants and improvement of the nervous system function maintaining the maturity of tissues in an organism.
Beliaev
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D000818:Animals; D002455:Cell Division; D003315:Cornea / Q000294:innervation / Q000473:pathology*; D003316:Corneal Diseases / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D016510:Corneal Neovascularization / Q000150:complications / Q000473:pathology / Q000628:therapy; D003714:Denervation; D005134:Eye Neoplasms / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D006801:Humans; D009416:Nerve Regeneration; D009882:Ophthalmic Nerve / Q000502:physiology* / Q000601:surgery; D011230:Precancerous Conditions / Q000209:etiology / Q000473:pathology* / Q000517:prevention & control; D011817:Rabbits
Zakonomernosti tkanevoĭ korreliatsii rogovitsy, ikh biologicheskoe znachenie v voprosakh regeneratsii i predopukholevogo rosta.