Expression of cyclin A in soft tissue sarcomas correlates with tumor aggressiveness.
Cyclins and cyclin-dependent kinases regulate the cell cycle. Cyclin A has a dual role in cell proliferation. It is essential in the S phase for DNA replication, and it is also involved in G2-M-phase transition, signifying actively dividing cells. The expression of cyclin A was determined by immunohistochemistry in paraffin sections of 126 soft tissue sarcomas. The median cyclin A score was 10.8% (range, 1-54%). Cyclin A expression correlated with the S-phase fraction, Ki-67 score, G2-M phase, and grade. It did not correlate with the size of the tumor. A high cyclin A score predicted a poor metastasis-free survival (P < 0.01) and a poor disease-specific overall survival (P = 0.01). We concluded that the expression of cyclin A is a powerful prognostic factor in soft tissue sarcoma. Moreover, the cyclin A score determines the fraction of tumor cells in the S phase and the G2 phase, which are the most sensitive cell cycle phases for current modalities of cancer treatment.
Huuhtanen
R L
RL
Helsinki University Central Hospital, Department of Oncology, Finland.
Blomqvist
C P
CP
Böhling
T O
TO
Wiklund
T A
TA
Tukiainen
E J
EJ
Virolainen
M
M
Tribukait
B
B
Andersson
L C
LC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002455:Cell Division / Q000502:physiology; D019925:Cyclin A / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D016195:G2 Phase / Q000502:physiology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D016196:S Phase / Q000502:physiology; D012509:Sarcoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D019925:Cyclin A; D019394:Ki-67 Antigen