Diurnal variation of antidiuretic hormone and urinary output in spinal cord injury.
BACKGROUND
Healthy individuals have a nocturnal decrease in urine output due to increased plasma antidiuretic hormone levels at night. This does not occur in spinal cord injury and most patients experience nocturnal polyuria, which triggers dysreflexic crises secondary to urinary bladder overdistension, and interferes with patients' sleep due to the need for extra catheterization.


OBJECTIVE
To evaluate the diurnal variation in ADH level, urinary output, and plasma and urine osmolality in SCI patients with regard to their level of injury and in comparison with age- and sex-matched healthy individuals.


METHODS
Sixteen ASIA-A spinal cord-injured patients, eight with paraplegia, eight with tetraplegia, and eight healthy individuals, were evaluated for urinary output, urine and serum osmolality, and antidiuretic hormone levels during day and night hours.


RESULTS
Absence of diurnal variation in urinary output and antidiuretic hormone secretion was detected in both paraplegic and tetraplegic patients, while antidiuretic hormone levels rose significantly at night in the control group.


CONCLUSIONS
Antidiuretic hormone levels should be monitored both day and night in spinal cord injury patients, with severe nocturnal polyuria. Treatment with desaminocystein-D-arginine vasopressin can be attempted when conservative measures fail to control nocturnal polyuria, especially in patients who are on an intermittent catheterization program.
Kilinç
S
S
Baskent University School of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey.
Akman
M N
MN
Levendoglu
F
F
Ozker
R
R
D000328:Adult; D000704:Analysis of Variance; D001798:Blood Proteins / Q000032:analysis; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000652:urine*; D011863:Radioimmunoassay; D013119:Spinal Cord Injuries / Q000097:blood* / Q000503:physiopathology / Q000652:urine*; D018709:Statistics, Nonparametric; D014667:Vasopressins / Q000097:blood*
D001798:Blood Proteins; D014667:Vasopressins