CD44s, E-cadherin and PCNA as markers for progression in renal cell carcinoma.
CD44s, E-cadherin and PCNA play an important role in the tumorigenesis of renal cell carcinoma (RCC), although their significance in the clinical progression of RCC is still not clear. In n = 137 cases of operatively resected RCC the expression of CD44s, E-cadherin and PCNA was semiquantitatively analyzed by the APAAP immunohistochemical method. The mean observation period of the n = 74 (54%) of patients with no evidence of disease was 52.6 months and for the n = 63 (46%) patients with progressive disease was 18.7 months. The mean progression free period occurring with absent or low levels of CD44s and PCNA expression was 79 and 118+ months, and with strong expression was 12 and 18 months (p < 0.001), respectively. With strong E-cadherin expression the progression free period was 110+ months, and with low expression 61 months (p = 0.01). A high CD44s/E-cadherin ratio and an above average PCNA expression were identified as independent prognostic parameters for the progression tendency of RCC.
Fischer
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C
Department of Urology, Justus-Liebig University, Giessen, Germany.
Georg
C
C
Kraus
S
S
Terpe
H J
HJ
Luedecke
G
G
Weidner
W
W
D015703:Antigens, CD / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009392:Nephrectomy; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D016019:Survival Analysis
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D015820:Cadherins; D018960:Hyaluronan Receptors; D018809:Proliferating Cell Nuclear Antigen