[The effect of cationic ferritin to the permeability of renal glomerular basement membrane and the mesangial area].
OBJECTIVE
To study the effect of cationic ferritin (CF) to the permeability of the glomerular basement membrane (GBM) and the mesangial area.


METHODS
Single dose of CF 50mg/kg/rat given intravenously. Samples taken from the kidney were studied under electronic microscope by polyethylenimine (PEI) staining.


RESULTS
The number of PEI granules in GBM changed obviously while those in the mesangial matrix (MM) remained unchanged.


CONCLUSIONS
The negative charge in GBM serves as a charge barrier relating with proteinuria and the MM serves as the lymphatic pathway with no connection with proteinuria.
Li
L
L
Department of Urology, 2nd Hospital, Dalian.
Shigeru
S
S
Kaoru
A
A
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D002463:Cell Membrane Permeability; D005293:Ferritins / Q000493:pharmacokinetics*; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar
C010297:polycationic ferritin; D005293:Ferritins