Mysterious liaisons: the relationship between c-Myc and the cell cycle.
A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the Cdk inhibitor p27KIP1. Cyclin D/Cdk4/6 complexes have also been implicated as targets of c-Myc activity. However, in spite of considerable effort, the mechanisms by which c-Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.
Obaya
A J
AJ
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Mateyak
M K
MK
Sedivy
J M
JM
D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D016271:Proto-Oncogene Proteins c-myc