title: Identification of human herpesvirus 8-specific cytotoxic T-cell responses.
abstract: Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.
authors.affiliation: Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, University College London, London, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Osman
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: J
authors.initials: J
authors.lastname: Gill
authors.forename: F
authors.initials: F
authors.lastname: Neipel
authors.forename: M
authors.initials: M
authors.lastname: Becker
authors.forename: G
authors.initials: G
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: B
authors.initials: B
authors.lastname: Gazzard
authors.forename: C
authors.initials: C
authors.lastname: Boshoff
authors.forename: F
authors.initials: F
authors.lastname: Gotch
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000821:virology; D000818:Animals; D002460:Cell Line; D002461:Cell Line, Transformed; D006224:Cricetinae; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; C111600:K1 protein, Human herpesvirus 8; C113454:K8.1 protein, Human herpesvirus 8; D009856:Oncogene Proteins, Viral; C100440:T0.7 protein, Human herpesvirus 8; D014764:Viral Proteins