Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man.
Epidemiological evidence indicates that moderate alcohol consumption is associated with a significant decrease in the incidence of certain cardiovascular disorders, which can lead to impaired quality of life and to death. However, there are no objective data suggesting a cause-effect relationship and detailed research based on definitive working hypotheses is needed. We tested two flavonoids in man and found that these substances can belong, at least in part, to a wine-dependent mechanism, which leads to increased adenosine plasma levels. If these results could be confirmed by analyzing all the possible influences leading to blood nucleoside increase, a hypothesis of diet-dependent cellular preconditioning could be discussed.
Blardi
P
P
Department of Internal Medicine, University of Siena, Italy. Blardi@unisi.it
De Lalla
A
A
Volpi
L
L
Di Perri
T
T
D000241:Adenosine / Q000097:blood*; D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D011794:Quercetin; D000241:Adenosine; D000077185:Resveratrol