Rapid gas chromatographic analysis of drugs of forensic interest.
High-speed gas chromatographic (GC) screening for drugs of forensic relevance is performed using a commercial Flash GC instrument in which the chromatographic column is resistively heated at rates of up to 30 degrees C/s. Temperature programming conditions are varied in an experiment designed to evaluate trade-offs between resolution and analysis time for a mixture of 19 drugs of abuse. All 19 components can be separated with excellent resolution in 90 s. Specific analytes can be analyzed even faster; for example, amphetamine analysis is completed in less than 20 s. Case studies of confiscated street drugs containing amphetamine, cocaine, and heroin are analyzed to evaluate the retention time repeatability. Ten replicate injections over a 2-day period for 3 different drug samples achieved retention time relative standard deviations in the range of 0.48 to 0.81%.
Williams
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Department of Chemistry & Biochemistry, University of South Carolina, Columbia 29208, USA.
Riddle
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Morgan
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Brewer
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D000661:Amphetamine / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods*; D003042:Cocaine / Q000032:analysis; D003415:Crime; D003932:Heroin / Q000032:analysis; D013287:Illicit Drugs / Q000032:analysis* / Q000331:legislation & jurisprudence; D007603:Jurisprudence; D013997:Time Factors
D013287:Illicit Drugs; D003932:Heroin; D000661:Amphetamine; D003042:Cocaine