title: HLA-DQA1, -DQB1 polymorphism distribution in Chinese women with pregnancy induced hypertension in Shanghai area.
abstract: OBJECTIVE
  To explore the association of human leukocyte antigen (HLA) with pregnancy induced hypertension (PIH).
  
  
  METHODS
  We oligotyped HLA-DQA1, -DQB1 locus of 30 Chinese PIH families and 14 control families in Shanghai area by polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) hybridization method (probes labeled by nonradioactive technique).
  
  
  RESULTS
  Compared with the control group, the allelic frequency of HLA-DQB1 * 0502 was significantly higher in PIH couples, and the sharing of HLA-DQA1 increased in PIH couples as well. No difference was found in HLA-DQA1 allelic frequencies or HLA-DQB1 sharing between the two groups. Analysis of neither HLA-DQA1 nor HLA-DQB1 allelic frequencies in PIH patients and PIH mother-and-fetuses showed positive result.
  
  
  CONCLUSIONS
  HLA-DQB1 * 0502 may be a marker of susceptibility to PIH. DQB1 * 0502 itself or some gene(s) located in HLA class II region and in linkage disequilibrium with 0502 affect maternal T cell immunity during pregnancy. The increase of compatibility in HLA-D region causes the production of blocking antibody to decrease.
authors.affiliation: Obstetrics and Gynecology Hospital of Shanghai Medical University, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Mao
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Fan
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
authors.forename: L
authors.initials: L
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: F
authors.initials: F
authors.lastname: Yao
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen