The Gly460Trp variant of alpha-adducin is not associated with hypertension in white Anglo-Australians.
A Gly460Trp variant of the cytoskeletal protein alpha-adducin has recently been implicated in the etiology of essential hypertension (HT) in a study involving southern European whites. We attempted to replicate this finding in a well-characterized, extensively studied group of 112 white Australians with essential HT, with strong family history (two HT parents), early-onset, moderate to severe disease, and of British extraction. Controls were 196 normotensive (NT) white subjects whose parents were both NT older than age 50 years. A mismatch polymerase chain reaction method involving BanII was developed for genotyping. Frequency of the Trp460 allele was 0.23 in the HT and 0.24 in the NT groups (chi2 = 0.2, P = .7). No association was observed with blood pressure, body mass index, age, plasma renin, angiotensinogen, angiotensin converting enzyme, cholesterol, triglycerides, or HDL or LDL cholesterol. Our results therefore provide no support for a role for the alpha-adducin variant in hypertension, at least in our severely affected Anglo-white group with strong family history of HT.
Wang
W Y
WY
Department of Physiology and Institute for Biomedical Research, The University of Sydney, New South Wales, Australia.
Adams
D J
DJ
Glenn
C L
CL
Morris
B J
BJ
D000483:Alleles; D000808:Angiotensinogen / Q000097:blood; D001315:Australia; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011110:Polymorphism, Genetic; D012083:Renin / Q000097:blood; D044465:White People; D000099291:Adducins
D000808:Angiotensinogen; D002148:Calmodulin-Binding Proteins; D003598:Cytoskeletal Proteins; D008055:Lipids; D007703:Peptidyl-Dipeptidase A; D012083:Renin; D000099291:Adducins