Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs.
OBJECTIVE
To study the pharmacokinetic behavior of 5-fluorouracil (5-FU) in pancreatic juice in dogs and its correlation with 5-FU in plasma, and to evaluate its penetration characteristics.


METHODS
After placing a pancreatico-drainage tube, 8 dogs were injected 5-FU 250 mg i.v. Blood and pancreatic samples were collected and the 5-FU concentrations were determined by HPLC. The pharmacokinetic parameters were obtained with statistical analysis.


RESULTS
The mean slopes of the terminal phase (K10) in plasma and pancreatic juice were 9.4 h-1 and 10.2 h-1, respectively (P > 0.05). The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model. Its penetration index was 3.39 +/- 2.84. The penetration of 5-FU from blood to pancreatic juice was relatively rapid, demonstrating a consistently higher concentration in pancreatic juice than in plasma.


CONCLUSIONS
The elimination phase of 5-FU in plasma was similar to that in pancreatic juice, indicating that they were in the same kinetic compartment.
Zhu
Z
Z
Department of Pharmacy, Peking Union Medical College Hospital, PUMC, Chinese Academy of Medical Sciences, Beijing, China. cprzhuz@public.bta.net.cn
Fu
Q
Q
Nightingale
C H
CH
Zhao
Y P
YP
Liao
Q
Q
Wang
H N
HN
Xue
C Q
CQ
Yang
Z Y
ZY
Li
D K
DK
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010189:Pancreatic Juice / Q000378:metabolism*
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil