title: Reply to comment
authors.affiliation: CRISCEB, Research Center of Computational and Biotechnological Sciences and Department of Biochemistry and Biophysics, Second University of Naples, via Costantinopoli 16, 80138 Naples, Italy.
authors.initials: AM
authors.lastname: Facchiano
authors.initials: G
authors.lastname: Colonna
authors.initials: R
authors.lastname: Ragone