Gonadal and Extragonadal Functions of Ad4BP/SF-1: Developmental Aspects.
Gene disruption studies have clearly indicated that 4-binding protein/steroidogenic factor 1 (Ad4BP/SF-1), originally identified as a steroidogenic tissue-specific transcription factor, plays crucial roles in the process of non-steroidogenic as well as steroidogenic tissue differentiation. Although the precise mechanisms underlying differentiation of these tissues are still under investigation, spatial and temporal expression profiles of the gene encoding Ad4BP/SF-1 support its contribution to tissue development from the earliest stages of ontogeny.
Morohashi
Ki
Division of Cell Differentiation, Department of Developmental Biology, National Institute for Basic Biology; the Department of Molecular Biomechanics, School of Life Science, The Graduate University for Advanced Studies; and CREST, Japan Science and Technology, Myodaiji-cho, Okazaki 444-8585, Japan.