title: Local radiation dose, fixation, and non-union of mandibulotomies.
abstract: BACKGROUND. Non-union of mandibulotomies is a serious complication but risk factors are unclear. No data are available on the effect of the specific dose of irradiation at the osteotomy site.
  
  
  METHODS
  Forty-eight patients (36 men, 12 women, median age 58 years) undergoing a mandibulotomy and postoperative radiotherapy were enrolled in the study. Twenty-five had wire and 23 had plate osteosyntheses. Five patients had a non-union and three had minor complications. The distribution of the radiation dose and the specific dose at the mandibulotomy site were calculated. Parametric tests and logistic regression were used for analysis.
  
  
  RESULTS
  Non-union was not related to a specific dose of irradiation at the osteotomy site. Also, no effect could be attributed to type of fixation.
  
  
  CONCLUSIONS
  There is no evidence for a single factor, radiation, or fixation type, that contributes to a non-union. We recommend a careful surgical technique.
authors.affiliation: Department of Oral and Maxillofacial Surgery/Oral Pathology, Academic Hospital Vrije Universiteit/ACTA, Amsterdam, The Netherlands. le.smeels@azvu.nl
authors.forename: L E
authors.initials: LE
authors.lastname: Smeele
authors.forename: B J
authors.initials: BJ
authors.lastname: Slotman
authors.forename: J W
authors.initials: JW
authors.lastname: Mens
authors.forename: R
authors.initials: R
authors.lastname: Tiwari
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery*; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D010027:Osteotomy / Q000009:adverse effects*; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D014945:Wound Healing