title: Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds.
abstract: Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the exons of E-cadherin by PCR-single-strand conformational polymorphism analysis in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases.
authors.affiliation: Second Department of Surgery, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iida
authors.forename: Y
authors.initials: Y
authors.lastname: Akiyama
authors.forename: W
authors.initials: W
authors.lastname: Ichikawa
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Nomizu
authors.forename: Z
authors.initials: Z
authors.lastname: Nihei
authors.forename: K
authors.initials: K
authors.lastname: Sugihara
authors.forename: Y
authors.initials: Y
authors.lastname: Yuasa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: D015820:Cadherins