Familial tumoral calcinosis: association with cerebral and peripheral aneurysm formation.
Two siblings with histologically and radiologically proven tumoral calcinosis presented with cerebral and peripheral aneurysms. The brother died of a ruptured subclavian artery aneurysm after surgical repair of brachial, iliofemoral and coeliac axis aneurysms. Magnetic resonance and catheter angiography in the sister demonstrated marked carotid dysplasia and a left ophthalmic segment aneurysm, not amenable to treatment. We believe this is the first reported case of familial aneurysms in association with tumoral calcinosis.
Adams
W M
WM
Department of Neuroradiology, Central Manchester Healthcare Trust, UK.
Laitt
R D
RD
Davies
M
M
O'Donovan
D G
DG
D000783:Aneurysm / Q000150:complications* / Q000235:genetics*; D002114:Calcinosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000235:genetics*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged