title: Rhinosinusitis and atopy in patients infected with HIV.
abstract: OBJECTIVE
  Rhinosinusitis is common during HIV infection; its prevalence is uncertain and could probably be related to clinical features, immunoallergological status, and diagnostic criteria
  
  
  METHODS
  Seventy-four patients hospitalized with HIV infection were prospectively evaluated for the presence of rhinosinusitis based on clinical findings, nasal endoscopy, or paranasal sinus computed tomography (CT). Immune status, nasal smear, features of atopy (based on the prick test), and its contribution to sinusal inflammatory pathology were also evaluated.
  
  
  RESULTS
  Most patients were severely immunosuppressed: CD4+ 155+/-201 cells/mL and 12+/-11% (mean +/- SD). Thirty-five percent of the patients presented at least two criteria of rhinosinusitis (clinical findings, nasal endoscopy, and CT: 35%; clinical findings and CT: 50%; nasal endoscopy and CT: 15%). CT scan showed multiple sinus involvement, opacification over 25% of the total volume of the maxillary sinus in 50% of patients, and opacification of the sphenoidal sinus in 40% of cases. Atopy was present in 18% of patients, a figure which reflects the expected prevalence in our geographic area. Two independent predictors were associated with a higher probability of rhinosinusitis: bilateral absence of maxillary infundibular patency (odds ratio, 7.5; 95% CI = 2.03-27.9) and low total count (odds ratio, 0.99; 95% CI = 0.99-1.00) or percentage of CD4+ (odds ratio, 0.93; 95% CI = 0.88-1.00).
  
  
  CONCLUSIONS
  There is a high prevalence of rhinosinusitis in HIV-infected individuals. This finding is related to a decreased cellular immunity, but it does not appear to be related to IgE-related immediate hypersensitivity. Nasal endoscopy should be the first-step diagnostic test. However, when clinical suspicion exists and endoscopy fails to explain symptoms, CT scan is a valuable adjunct to establish this diagnosis.
authors.affiliation: Department of Otolaryngology, Ciutat Sanitària i Universitària de Bellvitge, University of Barcelona, Spain. mcorominas@csub.scs.es
authors.forename: J F
authors.initials: JF
authors.lastname: García-Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Corominas
authors.forename: P
authors.initials: P
authors.lastname: Fernández-Viladrich
authors.forename: J L
authors.initials: JL
authors.lastname: Monfort
authors.forename: M
authors.initials: M
authors.lastname: Dicenta
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology* / Q000276:immunology; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology / Q000821:virology; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology / Q000821:virology; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology / Q000821:virology; D014057:Tomography, X-Ray Computed