title: Blood transfusion-acquired hemoglobin C.
abstract: Unexpected and confusing laboratory test results can occur if a blood sample is inadvertently collected following a blood transfusion. A potential for transfusion-acquired hemoglobinopathy exists because heterozygous individuals show no significant abnormalities during the blood donor screening process. Such spurious results are infrequently reported in the medical literature. We report a case of hemoglobin C passively transferred during a red blood cell transfusion. The proper interpretation in our case was assisted by calculations comparing expected hemoglobin C concentration with the measured value. A review of the literature on transfusion-related preanalytic errors is provided.
authors.affiliation: Department of Pathology, St Louis University, St Louis, MO, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Suarez
authors.forename: J M
authors.initials: JM
authors.lastname: Polski
authors.forename: B J
authors.initials: BJ
authors.lastname: Grossman
authors.forename: M F
authors.initials: MF
authors.lastname: Johnston
mesh_terms: D001797:Blood Protein Electrophoresis; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D005260:Female; D006444:Hemoglobin C / Q000032:analysis*; D006801:Humans; D008875:Middle Aged
chemical_list: D006444:Hemoglobin C