Efficacy and effects of short- and medium-term contraception in the common marmoset (Callithrix jacchus) using melengestrol acetate implants.
This study examines the effect of melengestrol acetate (MGA) implants on reproductive function and various biochemical parameters, ovarian activity, and uterine morphology in ten female common marmosets implanted for either 6-8 or 19-21 months. Measures of body weight, concentrations of urinary glucose and blood liver enzymes were taken. Ovarian activity was assessed by analysis of urinary progestin levels and ultrasound examinations of the ovaries. Ultrasonography was also used to evaluate uterine morphology. MGA was highly effective in preventing pregnancies in the study animals. No changes in biochemical parameters were found; however, seven females developed a substantial weight gain during the study. Follicular development was not suppressed, as indicated by the presence of antral follicles, luteinized structures, and elevated urinary progestin levels. The uteri of the MGA-treated subjects were moderately enlarged with a thickened endometrium that showed a marked change in structural appearance indicative of hypertrophy and decidualization. After implant removal these changes quickly disappeared and all females ovulated within 3 weeks and conceived within 4 months post-treatment. MGA appears to be an acceptable contraceptive in the marmoset, although non-steroidal methods should be evaluated as possible potential alternatives.
Möhle
U
U
Department of Reproductive Biology, German Primate Centre, Göttingen. moehle@www.dpz.gwdg.de
Heistermann
M
M
Einspanier
A
A
Hodges
J K
JK
D000818:Animals; D002144:Callithrix / Q000033:anatomy & histology / Q000502:physiology; D003267:Contraception / Q000379:methods / Q000662:veterinary*; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D003656:Decidua / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D005298:Fertility / Q000187:drug effects; D008552:Melengestrol Acetate / Q000008:administration & dosage*; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects; D011247:Pregnancy; D011276:Pregnanediol / Q000031:analogs & derivatives / Q000652:urine; D013997:Time Factors; D014463:Ultrasonography; D014599:Uterus / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000187:drug effects
D003271:Contraceptive Agents, Female; D004343:Drug Implants; C022270:pregnanediol-3 alpha-glucuronide; D008552:Melengestrol Acetate; D011276:Pregnanediol