Characterization of a polymorphism in the coding region of the human C5a anaphylatoxin receptor.
A polymorphism was identified in the coding region of the human C5a anaphylatoxin receptor gene leading to C to T transition at nucleotide position 450 (a silent substitution in the Ala150 codon, GCC to GCT). Its distribution was studied in a population of healthy volunteers from the Québec city region (prevalence of 2.8%) and among patients with end-stage renal failure who had previously undergone renal graft (prevalence 1.4%, not significantly different from that of the control group). This new marker provides a valuable tool to assess the risk for putative C5a-associated disorders with genetic determinism.
Marceau
F
F
Centre Hospitalier Universitaire de Québec, Centre de recherche du Pavillon l'Hôtel-Dieu de Québec, 11 Côte-du-Palais, Québec (Québec) G1R 2J6, Canada.
Bachvarova
M
M
Bergeron
J
J
Bachvarov
D R
DR
D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D015936:Complement C5a; D003596:Cytosine; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics; D011110:Polymorphism, Genetic; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement / Q000235:genetics*; D013941:Thymine
D015703:Antigens, CD; D044087:Receptor, Anaphylatoxin C5a; D011951:Receptors, Complement; D015936:Complement C5a; D003596:Cytosine; D013941:Thymine