title: The prognostic importance of severity and type of post-transplant proteinuria.
abstract: Proteinuria, developing after renal transplantation may influence allograft and patient outcomes. This study aimed to investigate the effect of proteinuria on patient and allograft survival. Among 514 patients, 56 (11%) patients with good allograft function and proteinuria were evaluated retrospectively. Patients with proteinuria were classified as group P (20 patients with permanent proteinuria, Male/Female: 16/4) and group T (36 patients with temporary proteinuria, M/F: 29/7) according to the type of proteinuria. Also, considering the amount of proteinuria, patients were classified as group M (32 patients with massive proteinuria, M/F: 29/3) and group NM (24 patients with non-massive proteinuria, M/F: 16/8). The mean time interval between transplantation and appearance of proteinuria was 23.7 months (range 0-121 months) and no difference was found between groups. Two- and 5-yr allograft survival rates were found to be 85 and 80% in group M, and 95 and 82% in group NM. respectively (p = 0.24). In terms of type of proteinuria, 2- and 5-yr allograft survival rates were found to be 70 and 58% in group P and 92 and 87% in group T, respectively. The difference between groups P and T was found to be statistically significant (p = 0.02). Most (85%) of the patients with permanent proteinuria also had massive proteinuria. In conclusion, we found a significant relation between type and severity of proteinuria. The type of post-transplant proteinuria had a stronger effect on allograft outcome than the severity of proteinuria.
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yildiz
authors.forename: R
authors.initials: R
authors.lastname: Erkoç
authors.forename: M S
authors.initials: MS
authors.lastname: Sever
authors.forename: A
authors.initials: A
authors.lastname: Türkmen
authors.forename: S T
authors.initials: ST
authors.lastname: Ecder
authors.forename: S
authors.initials: S
authors.lastname: Türk
authors.forename: I
authors.initials: I
authors.lastname: Kiliçarslan
authors.forename: E
authors.initials: E
authors.lastname: Ark
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D011507:Proteinuria / Q000209:etiology*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents