Serum apolipoprotein H and its relationship to lipids and other apolipoproteins in normal human men and women.
Apolipoprotein H (apo H), also known as beta-2-glycoprotein I, has recently become of considerable interest in the field of haemostasis. Because of the possible involvement of apo H in lipid pathways, we wished to test the hypothesis that the serum concentration of apo H was related to serum lipids and other apolipoproteins in normal individuals. One hundred and twenty-three healthy young subjects (67 women and 56 men) aged 22.7 +/- 0.70 years (mean +/- SD) were recruited. Serum level of apo H was higher in male subjects that in age-matched female subjects (167.6 +/- 47.5 mg/l versus 148.8 +/- 30.5 mg/l; P < 0.04). Serum levels of apo H were significantly correlated with serum concentration of cholesterol, but only in female subjects (r = 0.28, P < 0.02). No significant correlations were found between serum levels of apo H and triglycerides, high-density lipoprotein cholesterol, apo A1, apo B or lipoprotein (a) in either of the sexes.
Crook
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MA
Department of Chemical Pathology, Guy's and St Thomas' Hospital, London, UK.
Ch'ng
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Lumb
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D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D014280:Triglycerides / Q000097:blood; D053482:beta 2-Glycoprotein I
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006023:Glycoproteins; D008055:Lipids; D008562:Membrane Glycoproteins; D014280:Triglycerides; D053482:beta 2-Glycoprotein I; D002784:Cholesterol