[The effect of blood-pancreatic juice barrier on antitumor drugs excretion].
Chemotherapy is one of important adjuvant therapies for patients with pancreatic adenocarcinoma, but the mechamism 5-FU and MMC distributed over the pancreas is not known at home and abroad. Based on determining the ratio of the concentration of several kinds of antibioticsin plasma and pancreatic juice, we used fourteen dogs to study the distribution and the relationship of agents in plasma and pancreatic juice after giving 5-FU and MMC intravenously. At the same time, we observed some patients who received Whipple's operation. The results showed that 5-FU and MMC in plasma can penetrate the pancreatic tissue and cross the blood-pancreatic juice barrier (BPJB). Both agents suitable for the adjuvant chemotherapy of pancreatic adenocarcinoma.
Zhao
Y
Y
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.
Liao
Q
Q
Xue
C
C
D014670:Ampulla of Vater; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics; D000964:Antimetabolites, Antineoplastic / Q000493:pharmacokinetics*; D004285:Dogs; D005472:Fluorouracil / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D016685:Mitomycin / Q000493:pharmacokinetics; D010189:Pancreatic Juice / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil