Nonlinear models for in vitro kill kinetics of antibiotics.
In this study, we developed nonlinear regression models to analyze the data generated from an in vitro continuous culture system to assess the kinetics of metronidazole and trovafloxacin in inhibiting the growth of Bacteroides fragilis. The model includes parameters describing the initial shock effect of an antibiotic pulse, the overall antibiotic wash-out rate from the system, and the long-term toxicity of the antibiotic in the environment after one pulse and before the next pulse.
Lee
M L
ML
Channing Laboratory, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
DuBois
A
A
Ross
R A
RA
Onderdonk
A B
AB
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D001441:Bacteroides fragilis / Q000187:drug effects*; D024841:Fluoroquinolones; D008795:Metronidazole / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D008954:Models, Biological; D009287:Naphthyridines / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D017711:Nonlinear Dynamics; D012044:Regression Analysis
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D008795:Metronidazole; C080163:trovafloxacin