title: Function and dysfunction of the presenilins.
authors.affiliation: Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, Chicago, IL, USA ssisodia@drugs.bsd. uchicago.edu
authors.forename: S S
authors.initials: SS
authors.lastname: Sisodia
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: G
authors.initials: G
authors.lastname: Thinakaran
mesh_terms: D000328:Adult; D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008875:Middle Aged; D008954:Models, Biological; D053764:Presenilin-1; D053766:Presenilin-2; D051880:Receptors, Notch
chemical_list: D016564:Amyloid beta-Protein Precursor; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D051880:Receptors, Notch; C095907:SEL-12 protein, C elegans