title: Methods for defining and determining the clinical significance of treatment effects: description, application, and alternatives.
abstract: This article summarizes and scrutinizes the growth of the development of clinically relevant and psychometrically sound approaches for determining the clinical significance of treatment effects in mental health research by tracing its evolution, by examining modifications in the method, and by discussing representative applications. Future directions for this methodology are proposed.
authors.affiliation: Department of Psychology, University of Washington, Seattle 98195, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Jacobson
authors.forename: L J
authors.initials: LJ
authors.lastname: Roberts
authors.forename: S B
authors.initials: SB
authors.lastname: Berns
authors.forename: J B
authors.initials: JB
authors.lastname: McGlinchey
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D003627:Data Interpretation, Statistical; D019317:Evidence-Based Medicine / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D016011:Normal Distribution; D017063:Outcome Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data; D011613:Psychotherapy / Q000592:standards*; D012016:Reference Values