title: Relationship between fatigue and quality of life in patients with glioblastoma multiformae.
abstract: OBJECTIVE
  To evaluate changes in fatigue at the time of diagnosis (Time 1) and two weeks after the completion of radiation therapy (Time 2) and to determine the relationship between fatigue and quality of life (QOL) at each time interval in patients with glioblastoma multiformae (GBM).
  
  
  METHODS
  Descriptive study to evaluate fatigue and QOL.
  
  
  METHODS
  Neuro-oncology clinic for accrual. Clinic, home, or office for patients interviews.
  
  
  METHODS
  60 adult patients diagnosed with GBM who received radiation therapy.
  
  
  METHODS
  Participants completed a demographic data sheet, the Profile of Mood States, and the Multidimensional Quality of Life Scale-Cancer Version 2 at both time points.
  
  
  METHODS
  Fatigue and QOL.
  
  
  RESULTS
  Fatigue significantly increased from Time 1 to Time 2 (t = -2.69, p = 0.009). Increases in fatigue were associated with significant decreases in QOL at Time 1 (r = -0.57) and Time 2 (r = -0.60).
  
  
  CONCLUSIONS
  Patients with GBM experience increases in fatigue after radiation therapy. Increases in fatigue are associated with decreases in almost all aspects of patients' QOL.
  
  
  CONCLUSIONS
  Nurses must provide patients with information about the occurrence of fatigue during radiation therapy and recommend interventions to deal with this devastating symptom.
authors.affiliation: Center for Symptom Management, University of California at San Francisco, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Lovely
authors.forename: C
authors.initials: C
authors.lastname: Miaskowski
authors.forename: M
authors.initials: M
authors.lastname: Dodd
mesh_terms: D001932:Brain Neoplasms / Q000451:nursing* / Q000523:psychology* / Q000532:radiotherapy; D005221:Fatigue; D005260:Female; D005909:Glioblastoma / Q000451:nursing* / Q000523:psychology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009859:Oncology Nursing; D010353:Patient Education as Topic; D011581:Psychological Tests; D011788:Quality of Life