title: Meniscal substitutes--animal experience.
abstract: Animal studies have shown that meniscus allografts and tendon autografts generally heal to the capsule, are revascularized and repopulated with host cells. In animals, neither meniscal allografts nor tendon or fat autografts gain the properties of a normal meniscus. Meniscus allografts and tendon autografts are promising as both seem to offer some protection to the cartilage of the tibial plateau. There is no evidence that meniscal transplantation can prevent cartilage degenerative changes, and the long-term effect of meniscal transplantation on articular cartilage remains unknown. Whether cellular repopulation of the meniscal allograft is sufficient to restore its biomechanical properties is unknown. Collagen scaffolds and tissue engineered grafts are still under investigation, showing promising results especially for the former. Viable meniscal allografts should be implanted within 1 to 2 weeks after harvesting, as the production of proteoglycans decreases after 2 weeks.
authors.affiliation: Orthopaedic Hospital, Saarland University, Homburg/Saar, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Kohn
authors.forename: R
authors.initials: R
authors.lastname: Verdonk
authors.forename: H
authors.initials: H
authors.lastname: Aagaard
authors.forename: R
authors.initials: R
authors.lastname: Seil
authors.forename: M
authors.initials: M
authors.lastname: Dienst
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000601:surgery; D002478:Cells, Cultured; D006614:Hindlimb / Q000601:surgery; D008592:Menisci, Tibial / Q000503:physiopathology / Q000601:surgery* / Q000637:transplantation; D000070600:Tibial Meniscus Injuries; D014184:Transplantation, Homologous