Applications of knowledge discovery to molecular biology: identifying structural regularities in proteins.
In recent years, there has been an explosive amount of molecular biology information obtained and deposited in various databases. Identifying and interpreting interesting patterns from this massive amount of information has become an essential component in directing further molecular biology research. The goal of this research is to discover structural regularities in protein sequences by applying the Subdue discovery system to databases found in the Brookhaven Protein Data Bank. In this paper we report the results of applying Subdue to several classes of protein structures and discuss the potential significance of these results to the study of proteins.
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University of Texas at Arlington, USA. sandy_su@sabre.com
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D000595:Amino Acid Sequence; D016208:Databases, Factual; D019143:Evolution, Molecular; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D008967:Molecular Biology / Q000379:methods*; D008969:Molecular Sequence Data; D009211:Myoglobin / Q000737:chemistry; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012259:Ribonuclease, Pancreatic / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012984:Software
D006454:Hemoglobins; D009211:Myoglobin; D011506:Proteins; D012259:Ribonuclease, Pancreatic