Initiation of mammalian liver development from endoderm by fibroblast growth factors.
The signaling molecules that elicit embryonic induction of the liver from the mammalian gut endoderm or induction of other gut-derived organs are unknown. Close proximity of cardiac mesoderm, which expresses fibroblast growth factors (FGFs) 1, 2, and 8, causes the foregut endoderm to develop into the liver. Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the liver gene expression program, the latter being the first step of hepatogenesis. The hepatogenic response was restricted to endoderm tissue, which selectively coexpresses FGF receptors 1 and 4. Further studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm. Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.
Jung
J
J
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Box G-J363, Providence, RI 02912, USA.
Zheng
M
M
Goldfarb
M
M
Zaret
K S
KS
D000818:Animals; D046508:Culture Techniques; D004064:Digestive System / Q000196:embryology; D004627:Embryonic Induction; D004707:Endoderm / Q000378:metabolism / Q000502:physiology*; D016220:Fibroblast Growth Factor 1; D016222:Fibroblast Growth Factor 2 / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D015870:Gene Expression; D006321:Heart / Q000196:embryology; D006497:Heparan Sulfate / Q000494:pharmacology; D008099:Liver / Q000196:embryology* / Q000378:metabolism; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D009024:Morphogenesis; D009928:Organ Specificity; D011228:Prealbumin / Q000235:genetics; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D011993:Recombinant Fusion Proteins; D012709:Serum Albumin / Q000235:genetics; D015398:Signal Transduction; D000509:alpha-Fetoproteins / Q000235:genetics
D016220:Fibroblast Growth Factor 1; D016222:Fibroblast Growth Factor 2; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors; D006497:Heparan Sulfate; D011228:Prealbumin; D017468:Receptors, Fibroblast Growth Factor; D011993:Recombinant Fusion Proteins; D012709:Serum Albumin; D000509:alpha-Fetoproteins; C496457:Fgf8 protein, mouse