[Genotype, serotype and sensitivity to fluconazole of Candida albicans strains isolated from HIV-positive patients].
Genotype, serotype and susceptibility in vitro to fluconazole of 104 C. albicans strains isolated from HIV+ patients were studied. The possible correlations between genotype analysed by multilocus enzyme electrophoresis (MLEE) and phenotype of medical relevance (serotype and susceptibility to fluconazole) of Candida albicans isolated from these patients treated with fluconazole were evaluated by factorial correspondence analysis. No correlation was observed between genotype and in vitro or clinical response to fluconazole. In counterpart, serotype B C. albicans was associated with some multilocus genotypic patterns.
Bastide
J M
JM
Laboratoire d'Immunologie et Parasitologie, Faculté de Pharmacie, Montpellier.
Pujol
C
C
Mallié
M
M
Reynes
J
J
D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D015725:Fluconazole / Q000627:therapeutic use*; D005838:Genotype; D006679:HIV Seropositivity / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012703:Serotyping; D013045:Species Specificity
D000935:Antifungal Agents; D015725:Fluconazole
Génotype, sérotype et sensibilité au fluconazole de souches de Candida albicans isolées chez des patients VIH positif.