title: Bioactive sesquiterpenes from Santolina rosmarinifolia subsp. Canescens. A conformational analysis of the germacrane ring.
abstract: The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was carried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and antitumoral activity of selected compounds has been tested.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain. afbarre@goliat.ugr.es
authors.forename: A F
authors.initials: AF
authors.lastname: Barrero
authors.forename: M M
authors.initials: MM
authors.lastname: Herrador
authors.forename: J F
authors.initials: JF
authors.lastname: Quilez
authors.forename: R
authors.initials: R
authors.lastname: Alvarez-Manzaneda
authors.forename: D
authors.initials: D
authors.lastname: Portal
authors.forename: J A
authors.initials: JA
authors.lastname: Gavin
authors.forename: D G
authors.initials: DG
authors.lastname: Gravalos
authors.forename: M S
authors.initials: MS
authors.lastname: Simmonds
authors.forename: W M
authors.initials: WM
authors.lastname: Blaney
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes