title: A prospective study on quality of life of laryngeal cancer patients treated with radiotherapy.
abstract: BACKGROUND
  The aim of this study was to describe prospectively quality of life and mood before and after radiotherapy for laryngeal cancer.
  
  
  METHODS
  Sixty-five patients with Tis-T3 laryngeal cancer treated with radiotherapy completed the European Organization for Research and Treatment of Cancer (EORTC) Core Questionnaire, the EORTC Head and Neck Cancer module, and the Center for Epidemiologic Studies Depression Scale before treatment and 6 and 12 months later.
  
  
  RESULTS
  There was a significant but temporary deterioration of physical functioning, fatigue and most head and neck symptoms. Speech was the only symptom which improved. Patients with T2 tumors had significantly worse physical symptoms compared with patients with T1 tumors. There was a high level of depressive symptomatology at baseline, followed by an improvement after treatment.
  
  
  CONCLUSIONS
  After radiotherapy for laryngeal cancer, a temporary deterioration of physical functioning and symptoms occurs, mostly caused by side effects of treatment. Despite physical deterioration, there is an improvement of emotional functioning and mood after treatment, probably as a result of psychological adaptation and coping processes.
authors.affiliation: Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: de Graeff
authors.forename: R J
authors.initials: RJ
authors.lastname: de Leeuw
authors.forename: W J
authors.initials: WJ
authors.lastname: Ros
authors.forename: G J
authors.initials: GJ
authors.lastname: Hordijk
authors.forename: J J
authors.initials: JJ
authors.lastname: Battermann
authors.forename: G H
authors.initials: GH
authors.lastname: Blijham
authors.forename: J A
authors.initials: JA
authors.lastname: Winnubst
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome