title: [Hypereosinophilic syndrome complicated by myelofibrosis].
abstract: Hypereosinophilic syndrome (HES) with myelofibrosis was diagnosed in a 36-year-old man on the basis of bone marrow biopsy findings and clinical features. Although the patient was treated with steroid (1 mg/kg), hydroxyurea, and immunosuppressive therapy, eosinophilia persisted. Patients with HES and myelofibrosis are usually unresponsive to antineoplastic agents and/or immunosuppressants. However, cyclosporin may be an effective alternative for such patients.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical University.
authors.forename: S
authors.initials: S
authors.lastname: Okabe
authors.forename: N
authors.initials: N
authors.lastname: Yahata
authors.forename: T
authors.initials: T
authors.lastname: Tauchi
authors.forename: M
authors.initials: M
authors.lastname: Otawa
authors.forename: O
authors.initials: O
authors.lastname: Iwase
authors.forename: K
authors.initials: K
authors.lastname: Toyama
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: H
authors.initials: H
authors.lastname: Serizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
mesh_terms: D000328:Adult; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications*