Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS.
Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.
Rice
G P
GP
London Health Sciences Centre, Ontario, Canada.
Ebers
G C
GC
Lublin
F D
FD
Knobler
R L
RL
D000293:Adolescent; D000328:Adult; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000627:therapeutic use*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*
D000068576:Interferon beta-1b; D016899:Interferon-beta; D007052:Ibuprofen; D000068556:Interferon beta-1a