[Computer modeling in the study of mechanism of catalytic activity and the structure of active site of glutamine(asparagine)ase. I. Pharmacophore models of glutamine(asparagine)ase substrates].
Glutamine(asparagine)ase catalyses desamidation of both L-glutamine and L-asparagine, and their D-isomers. In this study the two-pharmacophore models of main enzyme substrates and their hydrolysed analogues were design. The received models reflect two stage of substrate interaction with the enzyme active site. These models allow to explain the wide substrate specificity of glutamine(asparagine)ase.
Veselovskiĭ
A V
AV
Institute of Biomedical Chemistry, PAMS, Moscow.
Lebedeva
Z I
ZI
Ivanov
A S
AS
Berezov
T T
TT
D000581:Amidohydrolases / Q000378:metabolism*; D001665:Binding Sites; D002384:Catalysis; D003198:Computer Simulation; D015195:Drug Design; D013379:Substrate Specificity
D000581:Amidohydrolases; C020654:glutamin-(asparagin-)ase
Issledovanie mekhanizma kataliticheskogo deĭstviia i struktury aktivnogo tsentra glutamin(asparagin)azy metodom komp'iuternogo modelirovaniia. I. Modeli farmakoforov substratov glutamin(asparagin)azy.