title: In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.
abstract: We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
authors.affiliation: Department of Neurology, Kyungpook National University School of Medicine, Taegu 700-412, South Korea.
authors.forename: S P
authors.initials: SP
authors.lastname: Park
authors.forename: F
authors.initials: F
authors.lastname: Lopez-Rodriguez
authors.forename: C L
authors.initials: CL
authors.lastname: Wilson
authors.forename: N
authors.initials: N
authors.lastname: Maidment
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: J
authors.initials: J
authors.lastname: Engel
mesh_terms: D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
chemical_list: D012701:Serotonin