title: Midlatency auditory-evoked potentials in the rat: effects of interventions that modulate arousal.
abstract: The vertex-recorded P13 midlatency auditory-evoked potential in the rat shows the same characteristics as the P1 potential in the human, namely, sleep-state dependence, rapid habituation and blockade by the cholinergic antagonist scopolamine. The P13 potential appears to be generated, at least in part, by projections of the pedunculopontine nucleus, the cholinergic arm of the reticular activating system. On the other hand, the auditory cortex-recorded P7 potential appears to be of primary cortical origin. Simultaneous recordings from the vertex and the auditory cortex showed that (1) the P13 potential was suppressed by administration of the anesthetics ketamine, pentobarbital or halothane in a dose-dependent manner, but the P7 potential was not; (2) the P13 potential was suppressed by intragastric injections of ethanol in a dose-dependent manner, but the P7 potential was not; (3) the amplitude of the P13 potential was negatively correlated with blood ethanol levels; (4) both the P13 and P7 potentials were still present following injections of the neuromuscular blocker pancuronium bromide; and (5) both the P13 and P7 potentials were decreased by diffuse brain injury induced by a weight-drop device in a weight-dependent manner. These findings suggest that the P13 potential is more sensitive than the P7 potential to changes in arousal and that the P13 and P7 potentials are not of myogenic but of neural origin.
authors.affiliation: Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
authors.forename: H
authors.initials: H
authors.lastname: Miyazato
authors.forename: R D
authors.initials: RD
authors.lastname: Skinner
authors.forename: M
authors.initials: M
authors.lastname: Cobb
authors.forename: B
authors.initials: B
authors.lastname: Andersen
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Rill
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D006259:Craniocerebral Trauma / Q000503:physiopathology; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000777:Anesthetics; D009466:Neuromuscular Blocking Agents; D000431:Ethanol; D007649:Ketamine; D010424:Pentobarbital; D006221:Halothane