[Prevalence of TT virus infection and viral integration in human hepatocellular carcinoma].
In 1997, Nishizawa et al cloned a novel DNA virus designated as TT virus (TTV) from a patient with post-transfusion hepatitis and this virus is being thought to be a new hepatitis virus. Approximately 5 to 10% of hepatocellular carcinomas (HCCs) in Japan occurs in hepatitis B virus-negative and hepatitis C virus-negative (NBNC) patients. In order to study the possible role of TTV in hepatocarcinogenesis, we studied the prevalence of the TTV DNA in liver tissue of HCC patients. As a result, TTV was shown not to be specific for NBNC HCC and TTV integration into host DNA was not detected in any HCC patient by Southern blotting.
Yamamoto
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Kajino
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Hino
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D015415:Biomarkers / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D004266:DNA Virus Infections / Q000453:epidemiology / Q000821:virology*; D004267:DNA Viruses / Q000235:genetics*; D004279:DNA, Viral / Q000032:analysis; D016679:Genome, Viral; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D015995:Prevalence; D016662:Virus Integration
D015415:Biomarkers; D004279:DNA, Viral