title: Correlation between human hepatocyte growth factor and interleukin-6 concentrations after surgery.
abstract: OBJECTIVE
  The aim of this study was to determine whether the production of human hepatocyte growth factor (hHGF) occurs in injured tissue following surgery in conjunction with interleukin-6 (IL-6) synthesis, and independently of liver resection.
  
  
  METHODS
  The post-operative concentrations of hHGF and IL-6 in the serum and local exudative fluid were measured in 33 patients following abdominal (n = 20) or thoracic surgery (n = 13) (non-HTX), and in 7 undergoing a partial hepatectomy (HTX).
  
  
  RESULTS
  Concentrations of two cytokines in the fluid were much higher than those in the serum (p < 0.001) in all patients. The maximum serum levels of hHGF were significantly correlated with those of IL-6 (p < 0.05), intra-operative blood loss (p < 0.005), and operating time (p < 0.005) in patients undergoing non-HTX. In these patients, the fluid levels of hHGF were also significantly correlated with those of IL-6 (p < 0.001). In serum and fluid, the hHGF/IL-6 ratios were markedly higher after HTX than after non-HTX (p < 0.05).
  
  
  CONCLUSIONS
  These results suggests that hHGF may be produced in conjunction with IL-6 in injured tissue following surgery, but the production of hHGF may predominate over that of IL-6 in the liver following partial hepatectomy.
authors.affiliation: Department of Surgery, Omiya Red Cross Hospital, Yono, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Suwa
authors.forename: C
authors.initials: C
authors.lastname: Kadoyama
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Ambiru
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000601:surgery*; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood*; D012016:Reference Values
chemical_list: D015850:Interleukin-6; D017228:Hepatocyte Growth Factor