Nutritional antioxidants as therapeutic and preventive modalities in exercise-induced muscle damage.
Several mechanisms have been forwarded to explain the etiology of exercise-induced muscle damage. Free-radical mediated processes appear to be an important component of the inflammatory mediated response. Free radicals have also been demonstrated to be a contributing factor in the loss of calcium homeostasis within the cell. Therefore, one of the proposed treatments for preventing or reducing the extent of this damage is the intervention of free-radical mediated processes. Antioxidants are agents that typically work to prevent free-radical mediated alterations within cells by quenching free radicals. The traditional dietary antioxidants most commonly investigated to inhibit free-radical damage are vitamin E, vitamin C, and beta carotene. Other nutritional agents have also been noted to contain antioxidant properties. Isofavonoids and some phytochemicals have been proposed to contain antioxidant properties. This paper briefly reviews some aspects of these agents and the! ! ir role, either proven or proposed, in the prevention of oxidative stress and muscle damage.
Goldfarb
A H
AH
Department of Exercise and Sport Science, University of North Carolina-Greensboro, 27402-6169, USA.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D005609:Free Radicals / Q000037:antagonists & inhibitors / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D010146:Pain / Q000378:metabolism / Q000473:pathology; D014810:Vitamin E / Q000627:therapeutic use; D019207:beta Carotene / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D007529:Isoflavones; D019207:beta Carotene; D014810:Vitamin E; D001205:Ascorbic Acid; D002118:Calcium