title: Assessment of command-following in minimally conscious brain injured patients.
abstract: OBJECTIVE
  To develop a method for establishing the presence of command-following in individuals with traumatic brain injury, based on the principles of single-subject experimental design.
  
  
  METHODS
  A series of single-subject experiments, individualized to the particular command-following question about a particular patient.
  
  
  METHODS
  An inpatient rehabilitation hospital with a specialized program for vegetative and minimally conscious brain injured patients.
  
  
  METHODS
  Eight individuals with serious brain injury of traumatic or nontraumatic origin, presenting in vegetative or minimally conscious states.
  
  
  METHODS
  The frequency of performance of the behavior in question was assessed in response to commands and in relation to appropriate control conditions. Data were analyzed with chi2 or Fisher's exact test, as well as measures derived from signal detection theory.
  
  
  METHODS
  The frequency of performance of a specific behavior in the presence of a command and in relevant contrasting conditions.
  
  
  RESULTS
  This method identified whether a specific behavior was being performed in response to command and whether the reliability of this behavior was changing over time either spontaneously or in response to treatment.
  
  
  CONCLUSIONS
  Quantitative assessment of command-following based on principles of single-subject experimental design can determine whether patients are capable of following commands and whether this ability changes over time or in response to treatment.
authors.affiliation: Moss Rehabilitation Research Institute, Philadelphia, PA 19141, USA.
authors.forename: J
authors.initials: J
authors.lastname: Whyte
authors.forename: M C
authors.initials: MC
authors.lastname: DiPasquale
authors.forename: M
authors.initials: M
authors.lastname: Vaccaro
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000523:psychology*; D003243:Consciousness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018458:Persistent Vegetative State; D012720:Severity of Illness Index