Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients.
OBJECTIVE
This study was undertaken to examine the effect of ketosis on plasma lipid peroxidation levels in diabetic patients.


METHODS
Plasma levels of lipid peroxidation products (malondialdehyde) and ketone bodies (acetoacetate and beta-hydroxybutyrate) were determined in diabetic patients (n = 70) and age-matched normal volunteers (n = 25). Diabetic patients with total ketone body levels > 1.0 mmol/l were considered hyperketonemic, and those with levels < or = 1.0 mmol/l were considered normoketonemic.


RESULTS
After normalization versus total lipids, levels of lipid peroxidation were significantly higher in the plasma of hyperketonemic diabetic patients (P < 0.05), but not in normoketonemic diabetic patients, compared with age-matched normal volunteers. In addition, low ketonemia was associated with lower lipid peroxidation levels when lipid peroxidation and ketonemia were determined in the same patient (n = 7) at two different clinic visits.


CONCLUSIONS
This study demonstrated an association between hyperketonemia and increased lipid peroxidation levels in diabetic patients, which suggests that ketosis is a risk factor in the elevated lipid peroxidation levels associated with diabetes. Further investigation is needed to determine whether antioxidant supplementation can be particularly beneficial in reducing lipid peroxidation and complications in type 1 diabetic patients who frequently encounter ketosis.
Jain
S K
SK
Department of Pediatrics, Louisiana State University Medical Center, Shreveport, USA.
McVie
R
R
Jackson
R
R
Levine
S N
SN
Lim
G
G
D020155:3-Hydroxybutyric Acid / Q000097:blood; D000090:Acetoacetates / Q000097:blood; D000328:Adult; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D016883:Diabetic Ketoacidosis / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007657:Ketone Bodies / Q000097:blood*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates; D006442:Glycated Hemoglobin; D007657:Ketone Bodies; D008055:Lipids; C016635:acetoacetic acid