title: Oxygen-enhanced magnetic resonance ventilation imaging of the human lung at 0.2 and 1.5 T.
abstract: Lung ventilation imaging using inhaled oxygen as a contrast medium was performed using both a 0.2 and a 1.5 T clinical magnetic resonance (MR) scanner in eight volunteers. Signal-to-noise-ratios (SNRs) of the ventilation images as well as T1 values of the lung acquired with inhalation of 100% oxygen and room air were calculated. The SNR was 9.7 +/- 3.0 on the 0.2 T MR system and 69.5 +/- 28.8 on the 1.5 T system (P < 0.001). The mean T1 value on the 0.2 T MR system with subjects breathing room air was 632 +/- 54 msec; with 100% oxygen, it was 586 +/- 41 msec (P < 0.01). At 1.5 T, the mean values were 904 +/- 99 msec and 790 +/- 114 msec, respectively (P < 0.0001). We conclude that MR oxygen-enhanced ventilation imaging of the lung is feasible with an open configured 0.2 T MR system.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Stock
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Morrin
authors.forename: H
authors.initials: H
authors.lastname: Hatabu
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D012119:Respiration
chemical_list: D010100:Oxygen