title: Family linkage study of the T-cell receptor genes in coeliac disease.
abstract: BACKGROUND
  The susceptibility to coeliac disease is genetically determined by possession of certain HLA DQ alleles, together with a one or more non-HLA genes. The central role of the T-cell receptor in disease pathogenesis makes the T-cell receptor genes strong candidates as disease susceptibility genes, and previous studies had provided equivocal ambiguous results.
  
  
  METHODS
  A pedigree based genetic linkage study was used to determine if any of the T-cell receptor genes have a role in the genetic aetiology of coeliac disease. Intragenic microsatellite markers were used to study T-cell receptor alpha, beta, and delta, while gamma was studied using two flanking microsatellites D7S484 and D7S629.
  
  
  RESULTS
  Conventional linkage analysis was performed using the MLINK computer package. Model-free linkage analysis was performed using MFLINK. No evidence of linkage between coeliac disease and the T-cell receptor genes was found in these pedigrees.
  
  
  CONCLUSIONS
  Mutations in the T-cell receptor genes are not implicated in the genetic aetiology of coeliac disease.
authors.affiliation: Department of Gastroenterology, Rayne Institute, St. Thomas Hospital, London.
authors.forename: J Y
authors.initials: JY
authors.lastname: Yiannakou
authors.forename: P M
authors.initials: PM
authors.lastname: Brett
authors.forename: M A
authors.initials: MA
authors.lastname: Morris
authors.forename: D
authors.initials: D
authors.lastname: Curtis
authors.forename: C
authors.initials: C
authors.lastname: Mathew
authors.forename: R
authors.initials: R
authors.lastname: Vaughan
authors.forename: S
authors.initials: S
authors.lastname: Rosen-Bronson
authors.forename: P J
authors.initials: PJ
authors.lastname: Ciclitira
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D002446:Celiac Disease / Q000235:genetics*; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019672:Genes, T-Cell Receptor; D008040:Genetic Linkage; D005819:Genetic Markers; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011159:Population Surveillance; D012680:Sensitivity and Specificity
chemical_list: D005819:Genetic Markers