IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.
The development of gene-knockout mice and the identification of gene-deficient humans have improved our understanding of the role of IL-12 and IFN-gamma in host defense. Comparison of experimental and natural infections has shown that animals and humans genetically deficient in immunity mediated by IL-12 or IFN-gamma are highly susceptible to mycobacteria and salmonella. Impaired secretion of, or response to, IFN-gamma is the common pathogenic mechanism that accounts for impaired granuloma formation and uncontrolled growth of bacteria within macrophages. The axis formed between IL-12 and IFN-gamma is essential for protective immunity against mycobacteria and salmonella in mice and men.
Jouanguy
E
E
Institut National de la Santé et de la Recherche Médicale Unité 429,Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France, EU.
Döffinger
R
R
Dupuis
S
S
Pallier
A
A
Altare
F
F
Casanova
J L
JL
D000818:Animals; D006801:Humans; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D018664:Interleukin-12 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D009161:Mycobacterium / Q000276:immunology*; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology; D012480:Salmonella Infections / Q000235:genetics / Q000276:immunology; D012481:Salmonella Infections, Animal / Q000235:genetics / Q000276:immunology
D018664:Interleukin-12; D007371:Interferon-gamma