An antisense oligonucleotide to brain-derived neurotrophic factor delays postural compensation following unilateral labyrinthectomy in guinea pig.
An antisense oligonucleotide to brain-derived neurotrophic factor (BDNF) was delivered by osmotic mini-pump at a 1 mM concentration via a cannula into the ipsilateral vestibular nucleus complex from 15 to 56h following unilateral labyrinthectomy in guinea pigs. Compared with the control groups, vestibular compensation of roll head tilt was significantly delayed (p < 0.05), while compensation of spontaneous nystagmus and yaw head tilt was unaffected. These results suggest that neurotrophins such as BDNF may be involved in specific aspects of the vestibular compensation process.
Bolger
C
C
Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand.
Sansom
A J
AJ
Smith
P F
PF
Darlington
C L
CL
D000222:Adaptation, Physiological; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D007758:Ear, Inner / Q000601:surgery*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D011187:Posture / Q000502:physiology*; D014726:Vestibular Nuclei
D019208:Brain-Derived Neurotrophic Factor; D016376:Oligonucleotides, Antisense