title: Comparison of bioactive glass to demineralized freeze-dried bone allograft in the treatment of intrabony defects around implants in the canine mandible.
abstract: BACKGROUND
  The purpose of this study was to evaluate and compare the healing of different bone grafting materials adjacent to titanium plasma-sprayed (TPS) endosseous dental implants.
  
  
  METHODS
  Implant osteotomy sites were prepared and standardized 3-walled intrabony defects (3 mm x 5 mm x 5 mm) were created at the mesial of each implant site. Thirty-two TPS implants were placed in edentulous mandibular ridges of the 4 dogs. Periodontal dressings were placed in the defect sites so as to create a defect simulating bone loss around an implant. After 3 months, the periodontal dressing was removed, the defect sites debrided and evaluated for size, and intramarrow penetration performed. The graft materials tested were 1) canine demineralized freeze-dried bone allograft (cDFDBA); 2) bioactive glass granules of a broad size range 90 to 710 microns (BRG); and 3) bioactive glass granules of narrow size range 300 to 355 microns (NRG). One site on each side of the mandible was not filled and served as a control. Dogs were sacrificed 4 months after graft placement.
  
  
  RESULTS
  Histologically, differences in percent bone-to-implant contact in the defect area were observed between the treatment groups. cDFDBA>control=BRG=NRG with statistical significance found between cDFDBA and control (P = 0.0379), but no statistically significant difference between control or either bioactive glass material. When comparing percent bone height fill of the defect in the grafted area, cDFDBA (65.7%) was significantly better than the control (48.9%; P < or = 0.05) with no statistically significant difference between control, broad range bioactive glass (57.3%) and narrow range bioactive glass (56.6%). When total bone area was measured, the percentage of new bone in the grafted area was cDFDBA (42.1%), broad range glass (33.1%) and narrow range glass (22.6%) with significance found between cDFDBA and NRG (P = 0.0102). The content of residual graft particles in soft tissue was significant (P = 0.0304) between cDFDBA (1.4%) and NRG (11.4%) with no significant difference between graft material for residual particle content in bone tissue.
  
  
  CONCLUSIONS
  The results of this study indicate that percent bone-to-implant contact and percent bone height fill in an intrabony defect around titanium plasma-sprayed implants are statistically significantly higher with the use of DFDBA when compared to bioactive glass material.
authors.affiliation: Department of Periodontics, University of Texas Health Science Center, San Antonio 78440, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Hall
authors.forename: R M
authors.initials: RM
authors.lastname: Meffert
authors.forename: J S
authors.initials: JS
authors.lastname: Hermann
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
authors.forename: D L
authors.initials: DL
authors.lastname: Cochran
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002516:Ceramics; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D007575:Jaw, Edentulous / Q000601:surgery; D008297:Male; D008334:Mandible / Q000601:surgery*; D010316:Particle Size; D011897:Random Allocation; D013499:Surface Properties; D014025:Titanium; D014184:Transplantation, Homologous; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D014025:Titanium