title: Deterioration in parkinsonism with low-dose pergolide.
abstract: The administration of dopamine agonists can have a role early in the course of Parkinson's disease, in an attempt to reduce the frequency of long-term motor complications associated with the use of levodopa. After treatment with dopamine agonists has begun, gradual dose escalation is recommended to reduce the incidence of side effects; at low doses, parkinsonian symptoms significantly decline in some patients, only to improve as the dose increases. We report a number of such patients and discuss the possible pathogenesis of this motor deterioration.
authors.affiliation: Walton Centre for Neurology and Neurosurgery, Fazakerley, Liverpool, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Kellett
authors.forename: M J
authors.initials: MJ
authors.lastname: Steiger
mesh_terms: D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy* / Q000473:pathology; D010479:Pergolide / Q000008:administration & dosage*; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D000978:Antiparkinson Agents; D011954:Receptors, Dopamine; D010479:Pergolide