Correlation between human hepatocyte growth factor and interleukin-6 concentrations after surgery.
OBJECTIVE
The aim of this study was to determine whether the production of human hepatocyte growth factor (hHGF) occurs in injured tissue following surgery in conjunction with interleukin-6 (IL-6) synthesis, and independently of liver resection.


METHODS
The post-operative concentrations of hHGF and IL-6 in the serum and local exudative fluid were measured in 33 patients following abdominal (n = 20) or thoracic surgery (n = 13) (non-HTX), and in 7 undergoing a partial hepatectomy (HTX).


RESULTS
Concentrations of two cytokines in the fluid were much higher than those in the serum (p < 0.001) in all patients. The maximum serum levels of hHGF were significantly correlated with those of IL-6 (p < 0.05), intra-operative blood loss (p < 0.005), and operating time (p < 0.005) in patients undergoing non-HTX. In these patients, the fluid levels of hHGF were also significantly correlated with those of IL-6 (p < 0.001). In serum and fluid, the hHGF/IL-6 ratios were markedly higher after HTX than after non-HTX (p < 0.05).


CONCLUSIONS
These results suggests that hHGF may be produced in conjunction with IL-6 in injured tissue following surgery, but the production of hHGF may predominate over that of IL-6 in the liver following partial hepatectomy.
Kimura
F
F
Department of Surgery, Omiya Red Cross Hospital, Yono, Japan.
Miyazaki
M
M
Suwa
T
T
Kadoyama
C
C
Itoh
H
H
Ambiru
S
S
Shimizu
H
H
Nakagawa
K
K
D000368:Aged; D016063:Blood Loss, Surgical / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000601:surgery*; D006498:Hepatectomy; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008111:Liver Function Tests; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood*; D012016:Reference Values
D015850:Interleukin-6; D017228:Hepatocyte Growth Factor