Permeability of tympanotomy tubes to ototopical preparations.
Myringotomy with tube placement is the most frequently performed otolaryngologic procedure in the United States, and purulent otorrhea after this procedure is not uncommon. Believing that ototopical preparations have proved useful in treating this malady, our group was compelled to examine whether and in what quantities these preparations are able to penetrate tympanotomy tubes. To this end, models were constructed and in vitro testing carried out with several popular formulations.
Arnold
D J
DJ
Department of Otolaryngology Head and Neck Surgery, University of Miami School of Medicine, Florida 33136, USA.
Bressler
K L
KL
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D005069:Evaluation Studies as Topic; D006801:Humans; D008876:Middle Ear Ventilation; D008953:Models, Anatomic; D010035:Otitis Media, Suppurative / Q000188:drug therapy*; D010539:Permeability; D011183:Postoperative Complications / Q000188:drug therapy*
D000900:Anti-Bacterial Agents