title: Age and renal prostaglandin inhibition during exercise and heat stress.
abstract: Aging is associated with a number of physiological changes that may cause the kidney to rely to a greater extent on vasodilatory PGs for normal functioning. Acute exercise has been shown to cause renal vasoconstriction that may be partially buffered by vasodilatory PGs. To determine the relative importance of renal PGs during exercise in older adults, we compared the renal effects of the PG inhibitor ibuprofen (1.2 g/day for 3 days) vs. a placebo control in a cohort of eight younger (24 +/- 2 yr) and eight older (64 +/- 2 yr) women during treadmill exercise ( approximately 57% maximal oxygen consumption) in the heat (36 degrees C). This over-the-counter dose of ibuprofen reduced renal PG (i.e., PGE2) excretion by 47% (P < 0. 05). Acute exercise in the heat caused dramatic decreases in glomerular filtration rate, renal blood flow, and sodium excretion in both age groups. PG inhibition was associated with greater decreases in urine production and free water clearance (P < 0.05). There were no drug-related declines in glomerular filtration rate or renal blood flow. We conclude that PG inhibition has only modest effects on renal function during exercise. Also, the lack of hemodynamic changes with PG inhibition indicates that healthy well-hydrated older women are not in a renal PG-dependent state.
authors.affiliation: Noll Physiological Research Center, Pennsylvania State University, University Park, Pennsylvania 16802-6900, USA. farquhar@mail.hrca.harvard.edu
authors.forename: W B
authors.initials: WB
authors.lastname: Farquhar
authors.forename: W L
authors.initials: WL
authors.lastname: Kenney
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D015232:Dinoprostone / Q000652:urine; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D018882:Heat Stress Disorders / Q000503:physiopathology*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008875:Middle Aged; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000652:urine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists; D012964:Sodium; D015232:Dinoprostone; D007052:Ibuprofen