title: Comparison of an amitraz-impregnated collar with topical administration of fipronil for prevention of experimental and natural infestations by the brown dog tick (Rhipicephalus sanguineus).
abstract: OBJECTIVE
  To compare the efficacies of amitraz and fipronil for prevention of experimental and natural infestations of Rhipicephalus sanguineus.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  30 dogs.
  
  
  METHODS
  In 3 trials, dogs were allocated to 3 groups of 10 each. In trial 1, dogs were experimentally infested on day--1, and on day 0 were fitted with an amitraz-impregnated collar, treated topically with fipronil, or not treated. Ticks were counted daily until day 7, when viability of ticks and their progeny was determined. In trial 2, dogs were treated on day 0 and experimentally infested on days 7, 8, 10, and 13. Ticks were counted on days 8, 10, 13, and 18, and viability of ticks and their progeny was determined on day 18. In trial 3, dogs were exposed weekly to a tick-infested environment from day--3 to day 70. Dogs were treated on day 0, and ticks were counted and removed weekly from day 3 to day 77.
  
  
  RESULTS
  Fipronil and amitraz were acaricidal and inhibited attachment and feeding. Amitraz had a significantly greater effect than fipronil on numbers of live, feeding ticks, egg hatchability, and larval viability, indicating partial ability to interrupt the tick life cycle. In field conditions, amitraz remained effective over the entire observation period.
  
  
  CONCLUSIONS
  Amitraz had stronger and more sustained effects against tick infestation than fipronil.
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, University of Zaragoza, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Estrada-Peña
authors.forename: F
authors.initials: F
authors.lastname: Ascher
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D016503:Drug Delivery Systems / Q000662:veterinary; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012098:Reproduction / Q000187:drug effects; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013987:Ticks / Q000502:physiology; D014052:Toluidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D007306:Insecticides; D011720:Pyrazoles; D014052:Toluidines; C014983:amitraz; C082360:fipronil