Inhibitory effect of some triterpenes from cacti on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoylphorbol-13-acetate.
Seventeen triterpenes isolated from cacti and the 10 derivatives were examined for the inhibition of tumor promoter-induced effects in vitro, such as stimulation of 32Pi-incorporation into phospholipids of cultured cells. Betulinic acid (1), cochalic acid (15), erythrodiol (16), oleanolic acid (21) and queretaroic acid (24) inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated 32Pi-incorporation into phospholipids of the cultured cells.
Kinoshita
K
K
Department of Pharmacognocy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Yang
Y
Y
Koyama
K
K
Takahashi
K
K
Nishino
H
H
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002642:Chick Embryo; D006367:HeLa Cells; D006801:Humans; D010743:Phospholipids / Q000378:metabolism*; D010761:Phosphorus Radioisotopes / Q000378:metabolism*; D010944:Plants / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
D002273:Carcinogens; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D014315:Triterpenes; D013755:Tetradecanoylphorbol Acetate