title: [The effect of protheo on pulmonary function and the change of its plasma concentration in patients with chronic asthmatic bronchitis].
abstract: OBJECTIVE
  In order to study the effect of protheo on pulmonary function and the change of its plasma concentration in patients with chronic asthmatic bronchitis.
  
  
  METHODS
  31 patients with chronic asthmatic bronchitis were treated by taking protheo 400 mg once a day orally for 6 weeks. The pulmonary functions, including FEV1, FVC, FEV1/FVC and PEFR, and the plasma concentrations of theophylline were measured respectively before and after the administration.
  
  
  RESULTS
  The results showed that the pulmonary functions after the therapy were greatly improved compared with that before the therapy, even after the administration for two weeks. In the second, fourth, sixth week of the therapy, the plasma levels of theophylline after taking protheo for 4 hours and 12 hours were both within the effective concentration.
  
  
  CONCLUSIONS
  Protheo is a kind of medicine with good effect, steady plasma concentration and less side effect for the patients with chronic asthmatic bronchitis.
authors.affiliation: Dept of Internal Medicine, Second Clinical College of China Medical University.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Tan
mesh_terms: D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001991:Bronchitis / Q000188:drug therapy / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000097:blood; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D013806:Theophylline