[Pharmacological vigilance and pharmacological epidemiology: principles, definition, methods and current trends in neurology].
It is now well established that only clinical trials performed before drug approval are not sufficient for a full modern pharmacological evaluation of drugs and treatments. The need of both pharmacovigilance and pharmacoepidemiology is underlined in order to evaluate drugs under real conditions. After a summary of methods used in pharmacoepidemiological trials (spontaneous reports, imputability assessment, cohorts, case control studies etc.), recent pharmacoepidemiological data useful for the neurologist are summarized: side effects of tacrine and vaccines, serotoninergic syndrome and side effects of new antiepileptic drugs.
Montastruc
J L
JL
Service de Pharmacologie Clinique, Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Faculté de Médecine, Hôpitaux de Toulouse.
Bagheri
H
H
Lapeyre-Mestre
M
M
Senard
J M
JM
D000927:Anticonvulsants / Q000009:adverse effects; D002800:Cholinesterase Inhibitors / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004813:Epidemiology; D006801:Humans; D008099:Liver / Q000187:drug effects; D008389:Marketing of Health Services; D009462:Neurology / Q000639:trends*; D010600:Pharmacology; D017366:Serotonin Receptor Agonists / Q000009:adverse effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects; D013619:Tacrine / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects
D000927:Anticonvulsants; D002800:Cholinesterase Inhibitors; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors; D013619:Tacrine; D014765:Viral Vaccines
Pharmacovigilance et pharmacoépidémiologie: principes, définition, méthodes et actualités en neurologie.