title: Plasma atrial and brain natriuretic peptide levels in dogs with congestive heart failure.
abstract: Plasma concentrations of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were measured in 6 dogs with experimental mitral regurgitation (MR) and 19 canine patients with asymptomatic and symptomatic congestive heart failure (CHF). In dogs with experimental MR, ANP and BNP concentrations were significantly correlated with pulmonary capillary wedge pressure (PCWP) (ANP; r=0.852, P=0.0004, BNP; r=0.832, P=0.0008). ANP level was shown to have a predominant effect on PCWP in comparison with BNP using multiple regression analysis. In canine patients with asymptomatic and symptomatic CHF, ANP and BNP concentrations were significantly different among the heart failure classes according to the New York Heart Association functional classification (ANP; P=0.0165, BNP; P=0.0005). In addition, ANP and BNP levels in dogs with decompensated heart failure (n=10) significantly increased in comparison with those in dogs with compensated heart failure (n=9). There was however no correlation between ANP and BNP levels in each heart failure class. In conclusion, plasma ANP and BNP levels may become predictors of PCWP and the severity of heart failure in dogs with MR, although further investigations on ANP and BNP levels in more clinical cases are required.
authors.affiliation: Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Kadosawa
authors.forename: T
authors.initials: T
authors.lastname: Fujinaga
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000097:blood / Q000503:physiopathology / Q000662:veterinary; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011669:Pulmonary Wedge Pressure; D012044:Regression Analysis
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor