[A comparative study of TTV co-infection in patients with chronic liver disease B, C and non-B non-C].
The TTV DNA were examined in patients with chronic liver diseases B (n = 35), C (n = 44) and non-B non-C (n = 19). The clinical background, liver function and liver histological finding were compared in patients with or without TTV infection. The prevalence of TTV in patients with chronic liver diseases B, C and non-B non-C were 37.1%, 27.3% and 52.6%, respectively. There was no significant difference in liver function test between TTV positive and negative patients with chronic liver diseases B and C. The gamma-GTP level of TTV positive patients were significantly higher than that of TTV negative patients with chronic liver diseases non-B non-C. The histological findings were similar between patients with or without TTV infection. We concluded that even though the co-infection of TTV in patients with chronic liver diseases B and C was high, TTV does not act as a liver injury agent. The relationship between TTV and non-B non-C chronic liver diseases is unclear.
Asaba
N
N
Third Department of Internal Medicine, Kyorin University School of Medicine.
Okamura
H
H
Tokuue
H
H
Takasu
M
M
Takahashi
S
S
Saito
S
S
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D004266:DNA Virus Infections / Q000150:complications* / Q000821:virology; D004267:DNA Viruses / Q000302:isolation & purification; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D004279:DNA, Viral