[Long-term survival of fetal substantia nigra grafts in striatum of PD rats: an observation of tyrosine hydroxylase immunohistochemistry and western blot].
By using immunohistochemistry and Western blot, we observed the varied patterns of survival, development and growth of dopaminergic neurons after intrastriatal transplantation of fetal substantia nigra. There was a phenomenon of "developmental delay" of grafts in the host. As the time of transplantation went on, the grafted dopaminergic neurons could reinnervate the host neurons. The observation reveals that the reinnervation between graft and host is more beneficial to the functioning of the grafts.
Yang
H
H
Department of Neurosurgery, Xinqiao Hospital, 3rd Military Medical College, Chongqing.
Cai
W
W
Zhang
K
K
D000818:Animals; D016380:Brain Tissue Transplantation; D003342:Corpus Striatum / Q000601:surgery*; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D010300:Parkinson Disease / Q000601:surgery*; D051381:Rats; D013378:Substantia Nigra / Q000196:embryology / Q000637:transplantation*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase