Impact of localized radiotherapy on blood immune cells counts and function in humans.
Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT.
Belka
C
C
Department of Radiation Oncology, Eberhard Karls University Tübingen, Germany.
Ottinger
H
H
Kreuzfelder
E
E
Weinmann
M
M
Lindemann
M
M
Lepple-Wienhues
A
A
Budach
W
W
Grosse-Wilde
H
H
Bamberg
M
M
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology / Q000528:radiation effects; D018655:Lymphocyte Count / Q000528:radiation effects; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011446:Prospective Studies; D018239:Seminoma / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D013736:Testicular Neoplasms / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery