Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea.
We report the case of a 63-yr-old man who had severe secretory diarrhea associated with colonic adenocarcinoma, with a prominent signet ring cell component and numerous endocrine cells as demonstrated by positive chromogranin-A staining. Improvement in the secretory diarrhea by the somatostatin analog Sandostatin suggested that the diarrhea was related to a functional neuroendocrine tumor within the colonic tumor, the first case to be reported in the literature.
Lew
E A
EA
CURE, Department of Medicine, UCLA Medical Center, Los Angeles, California, USA.
Lewin
K J
KJ
Zarchy
T
T
Pisegna
J R
JR
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology* / Q000556:secondary; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D003110:Colonic Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D003967:Diarrhea / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology*; D013194:Staining and Labeling
D053379:Chromogranin A; D002864:Chromogranins