Congenital osteoclast deficiency in osteopetrotic (op/op) mice is improved by ovariectomy and orchiectomy.
We examined the changes in the appearance of osteoclasts in the femora of ovariectomized (OVX) or orchiectomized (ORX) op/op mice. Osteoclasts on the trabecular bone surface of the OVX or ORX op/op mice significantly increased in number seven or eight times in comparison with sham-operated op/op mice. Furthermore, TRAP-positive cells increased about four times in 100-week-old females and males, compared with sham-operated groups. These results have indicated that a sex hormone reduction due to OVX or ORX induces prominent recruitment of osteoclasts in op/op mice.
Kawata
T
T
Department of Orthodontics, Hiroshima University School of Dentistry, Japan.
Fujita
T
T
Kumegawa
M
M
Tanne
K
K
D000818:Animals; D001862:Bone Resorption / Q000151:congenital* / Q000503:physiopathology; D005260:Female; D008297:Male; D051379:Mice; D009919:Orchiectomy / Q000662:veterinary*; D010010:Osteoclasts / Q000502:physiology; D010022:Osteopetrosis / Q000151:congenital* / Q000503:physiopathology; D010052:Ovariectomy / Q000662:veterinary*