[Intrascrotal malignant fibrous histiocytoma].
OBJECTIVE
To describe a rare case of intrascrotal malignant fibrous histiocytoma.


METHODS
A 90-year-old man presented with a scrotal mass which he had noted during the past few months. A scrotal tumor, 8 cm in diameter, was detected on physical evaluation. Tumor resection was decided due to the patient's good general condition despite his age.


RESULTS
The histological analysis confirmed a sarcomatoid neoplasm with pleomorphism. The immunohistochemical analysis demonstrated strong overexpression of vimentin, alpha-1-antichymotrypsin, CD68 (Kpl), p53 oncoprotein and elevated Ki67. The ultrastructural study showed undifferentiated mesenchymal cells. The diagnosis of intrascrotal malignant fibrous histiocytoma was made based on the foregoing findings.


CONCLUSIONS
Malignant fibrous histicytoma should be included in the differential diagnosis of intrascrotal tumors. Histological, immunohistochemical and ultrastructural studies are very important to distinguish the different paratesticular sarcomas. The strong overexpression of the p53 oncoprotein may be involved in the pathogenesis of this tumor type.
Medina Pérez
M
M
Servicio de Anatomía Patológica, Hospital de la Merced, Osuna, Sevilla, España.
Valero Puerta
J
J
Valpuesta Fernández
I
I
Pérez Martín
D
D
D000368:Aged; D000369:Aged, 80 and over; D005834:Genital Neoplasms, Male / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008297:Male; D012611:Scrotum / Q000473:pathology
Histiocitoma fibroso maligno intraescrotal.