Chemokine receptors in lymphoid organ homeostasis.
Leukocytes respond to complex patterns of chemoattractant cytokine (chemokine) gradients that guide them to their destinations in secondary lymphoid organs. This directed movement of multiple cell types requires the choreographed expression of specific G-protein-coupled chemokine receptors and both positive and negative regulation of the signal transduction pathways emanating from them.
Jung
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Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. jung@saturn.med.nyu.edu
Littman
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D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D008954:Models, Biological; D019707:Receptors, Chemokine / Q000378:metabolism*; D015398:Signal Transduction
D008024:Ligands; D019707:Receptors, Chemokine; D019204:GTP-Binding Proteins