title: Construction of a variability map for eukaryotic large subunit ribosomal RNA.
abstract: In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.
authors.affiliation: Department of Biochemistry, University of Antwerp (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Ben Ali
authors.forename: J
authors.initials: J
authors.lastname: Wuyts
authors.forename: R
authors.initials: R
authors.lastname: De Wachter
authors.forename: A
authors.initials: A
authors.lastname: Meyer
authors.forename: Y
authors.initials: Y
authors.lastname: Van de Peer
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence / Q000235:genetics; D005057:Eukaryotic Cells; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D020407:Internet; D008970:Molecular Weight; D009690:Nucleic Acid Conformation; D010944:Plants; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics*; D012441:Saccharomyces cerevisiae; D016415:Sequence Alignment
chemical_list: D012335:RNA, Ribosomal