Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression.
We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.
Stan
A C
AC
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
Walter
G F
GF
Welte
K
K
Schneider
B
B
Bona
C A
CA
Pietsch
T
T
D000293:Adolescent; D000328:Adult; D001253:Astrocytes / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation / Q000276:immunology; D003720:Densitometry; D018450:Disease Progression; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis; D005909:Glioblastoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009836:Oligodendroglia / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D009837:Oligodendroglioma / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D012008:Recurrence
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D016179:Granulocyte Colony-Stimulating Factor