[Akathisia, parkinsonism and depression induced by cinnarizine: a case report].
BACKGROUND
Cinnarizine is a calcium-entry blocker drug used in vertiginous disorders; among its most rare adverse effects appear extrapyramidal symptoms and depression, these effects can persist during weeks, months or years after the withdrawal of the drug and have been explained by the inhibition of the passage of calcium in striatal neurons and a direct antidopaminergic features because of the similar chemical structure with neuroleptic drugs. Clinical case. A case of cinnarizine-induced akathisia, parkinsonism and depression in a 25 years-old patient after 11 days of treatment is described. Sequential evaluation were done using the following instruments: Barnes' scale for akathisia, Simpson-Angus scale for extrapyramidal symptoms, Beck's depression scale, Zung's depression scale and SCID for major depression according to DSM-IV criteria. The patient was treated with benzodiazepines, propranolol and orphenadrine.


CONCLUSIONS
Although cinnarizine-induced extrapyramidal symptoms and depression have been associated with old age and prolonged time of treatment, it must be considered its apparition among young patients and after a short time of treatment.
Stucchi-Portocarrero
S
S
Instituto Nacional de Salud Mental Honorio Delgado-Hideyo Noguchi, Lima, Perú. stucchi@amauta.rcp.net.pe
Vega-Dienstmaier
J M
JM
Saavedra
J E
JE
Sagástegui
A
A
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000175:diagnosis; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D002936:Cinnarizine / Q000009:adverse effects*; D003866:Depressive Disorder / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000175:diagnosis; D012720:Severity of Illness Index; D014717:Vertigo / Q000188:drug therapy
D002121:Calcium Channel Blockers; D002936:Cinnarizine
Acatisia, parkinsonismo y depresión inducidos por cinaricina: descripción de un caso.