Description of a possible clonal expansion of Plasmodium vivax in Manaus-Amazonas-Brazil.
Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting chloroquine and primaquine resistance. A unique isolate, found at all stages of infection, suggests the presence of a clonal expansion.
Alecrim
M dos G
Mdos G
Fundação de Medicina Tropical do Amazonas da Universidade do Amazonas, Brasília.
Alecrim
W D
WD
Macêdo
V
V
Korves
C T
CT
Roberts
D R
DR
Li
J
J
Sullivan
M
M
McCutchan
T F
TF
D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002738:Chloroquine / Q000627:therapeutic use; D002999:Clone Cells; D004351:Drug Resistance; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D010966:Plasmodium vivax / Q000235:genetics*; D011319:Primaquine / Q000627:therapeutic use
D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine