[The proliferation inhibition and differentiation inducing effects of all-trans retinoic acid on human pancreatic adenocarcinoma cell line JF-305].
We detected the antiproliferative effect with MTT test and investigated the changes in biological properties, cytomorphology and ultrastructure through cytopathology and electronic microscopy. Cell growth of JF-305 was inhibited by all-trans retinoic acid (ATRA). The maximal inhibitory rate was 34.7%. The number of proliferative cells reduced (P < 0.01). Cell metabolism slowed down, secretory functions recovered, and malignant degree decreased. ATRA can inhibit the proliferation and induce the differentiation of human pancreatic adenocarcinoma JF-305 cells.
Liu
D
D
Second Clinical Hospital of China Medical University, Shenyang.
Wang
Y
Y
Wang
B
B
D000230:Adenocarcinoma / Q000473:pathology* / Q000648:ultrastructure; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D014212:Tretinoin