title: Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
abstract: Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or "phen-fen") was recently marketed in the United States. We describe a case of a 39-year-old woman with rapidly progressing, fatal pulmonary hypertension following administration of phentermine-fenfluramine. Autopsy was remarkable for complex pulmonary vascular lesions most consistent with thrombotic arteriopathy.
authors.affiliation: Department of Pathology, University of California, San Diego, La Jolla, CA 92093-0624, USA.
authors.forename: J
authors.initials: J
authors.lastname: Strother
authors.forename: P
authors.initials: P
authors.lastname: Fedullo
authors.forename: E S
authors.initials: ES
authors.lastname: Yi
authors.forename: E
authors.initials: E
authors.lastname: Masliah
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000473:pathology; D010645:Phentermine / Q000009:adverse effects*; D011651:Pulmonary Artery / Q000187:drug effects / Q000473:pathology; D013927:Thrombosis / Q000473:pathology; D014652:Vascular Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D001067:Appetite Depressants; D005277:Fenfluramine; D010645:Phentermine