title: Effect of procainamide on ultrastructure of blood platelet in rabbits.
abstract: OBJECTIVE
  To study the effect of procainamide (PA) on the ultrastructure of blood platelets.
  
  
  METHODS
  Arachidonic acid was added to PA-treated platelet-rich plasma to induce platelet aggregation. The 50-nm sections were examined with a transmission electron microscope.
  
  
  RESULTS
  PA 8.5-136 mumol.L-1 markedly inhibited changes of pseudopods, alpha-granules, dense granules, glycogens, open canalicular system, and dense tubular system.
  
  
  CONCLUSIONS
  PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.
authors.affiliation: Department of Electron Microscopy, First Military Medical University, Guangzhou, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Liu
authors.forename: C W
authors.initials: CW
authors.lastname: Shan
authors.forename: X H
authors.initials: XH
authors.lastname: Liu
authors.forename: H C
authors.initials: HC
authors.lastname: Xiao
authors.forename: S Q
authors.initials: SQ
authors.lastname: Yang
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011342:Procainamide / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D010975:Platelet Aggregation Inhibitors; D011342:Procainamide