title: Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature.
abstract: A 78-year-old Japanese female was admitted to our hospital with dysphagia and weight loss. An oesophageal tumour was demonstrated radiologically and endoscopically, and was diagnosed as oesophageal cancer by biopsy. Histologically, the resected tumour showed poorly differentiated squamous cell carcinoma with prominent lymphoid stroma and was diagnosed as the so-called lymphoepithelioma-like carcinoma (LELC). Epstein-Barr virus in the tumour was negative by polymerase chain reaction and in situ hybridization. Oesophageal LELC is extremely rare. The cases in the literature, as well as the one reported here, presented with gross features of a submucosal tumour-like appearance. Although the differentiation of the tumour cells is often poor, prognosis seems to be better than for other types of oesophageal cancer. Oesophageal LELC has characteristic clinicopathological features and should be classified by criteria independent of other types of tumour.
authors.affiliation: Second Department of Surgery, School of Medicine, Chiba University, Japan. sasiyama@virolo3.m.chiba-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Sashiyama
authors.forename: A
authors.initials: A
authors.lastname: Nozawa
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: E
authors.initials: E
authors.lastname: Nomura
authors.forename: J I
authors.initials: JI
authors.lastname: Tamaru
authors.forename: E
authors.initials: E
authors.lastname: Ninomiya
authors.forename: Y
authors.initials: Y
authors.lastname: Koide
authors.forename: M
authors.initials: M
authors.lastname: Iino
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000235:genetics; D011859:Radiography
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral