title: Multislice perfusion and perfusion territory imaging in humans with separate label and image coils.
abstract: An arterial spin labeling technique using separate RF labeling and imaging coils was used to obtain multislice perfusion images of the human brain at 3 T. Continuous RF irradiation at a peak power of 0.3 W was applied to the carotid arteries to adiabatically invert spins. Labeling was achieved without producing magnetization transfer effects since the B1 field of the labeling coil did not extend into the imaging region or couple significant power into the imaging coil. Eliminating magnetization transfer allowed the acquisition of multislice perfusion images of arbitrary orientation. Combining surface coil labeling with a reduced RF duty cycle permitted significantly lower SAR than single coil approaches. The technique was also found to allow selective labeling of blood in either carotid, providing an assessment of the artery's perfusion territory. In normal subjects, these territories were well-defined and localized to the ipsilateral hemisphere.
authors.affiliation: Division of Health Sciences and Technology, MIT/Harvard Medical School, Cambridge, Massachusetts 02139, USA.
authors.forename: G
authors.initials: G
authors.lastname: Zaharchuk
authors.forename: P J
authors.initials: PJ
authors.lastname: Ledden
authors.forename: K K
authors.initials: KK
authors.lastname: Kwong
authors.forename: T G
authors.initials: TG
authors.lastname: Reese
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
authors.forename: L L
authors.initials: LL
authors.lastname: Wald
mesh_terms: D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology*; D002339:Carotid Arteries / Q000033:anatomy & histology*; D017352:Echo-Planar Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*