Successful treatment of refractory acquired pure red cell aplasia (PRCA) by allogeneic bone marrow transplantation.
This case describes a 16-year-old woman treated successfully by a bone marrow transplant from her HLA-identical brother for refractory acquired pure red cell aplasia. Conditioning was as for severe aplastic anaemia with cyclophosphamide 4 x 50 mg/kg and antithymocyte globulin. Complete donor type engraftment at 3 months reversed to full autologous reconstitution at 2 years with normal haemopoiesis. The potential implications on pathogenesis of the disease as well as on treatment of autoimmune disorders by stem cell transplantation are discussed.
Müller
B U
BU
Department of Medicine, Kantonsspital, University of Basel, Switzerland.
Tichelli
A
A
Passweg
J R
JR
Nissen
C
C
Wodnar-Filipowicz
A
A
Gratwohl
A
A
D000293:Adolescent; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000628:therapy*; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents