title: Clinical and laboratory manifestations of elderly onset psoriatic arthritis: a comparison with younger onset disease.
abstract: OBJECTIVE
  Although the influence of age on clinical and laboratory features has been widely demonstrated in many arthropathies, studies on elderly onset (> 60 years) psoriatic arthritis (EOPsA) are rare. This study compares manifestations at onset and two year outcome of EOPsA with those of younger onset PsA (YOPsA).
  
  
  METHODS
  Sixty-six consecutive PsA patients with disease duration < 1 year, 16 EOPsA (> 60 years) and 50 YOPsA (< or = 60 years) were admitted to a prospective study. Clinical, laboratory, and radiographic assessment were carried out at admission and after two years. HLA class I and bone scintigraphy were also recorded. In 10 patients with EOPsA and 24 with YOPsA it was possible to obtain synovial fluid, which was subsequently analysed for local inflammatory indices, including interleukin (IL) 1 beta, IL6, and IL8.
  
  
  RESULTS
  Presenting manifestations of EOPsA differed from YOPsA in number of active joints (mean (SD)) (12.2 (6.3) v 6.7 (4.6), p < 0.001), foot bone erosions (2.7 (1.2) v 1.1 (1.1), p < 0.001), erythrocyte sedimentation rate (64.2 (35.3) v 30.5 (30.0) mm 1st h, p < 0.001), C reactive protein (3.9 (2.0) v 1.3 (1.3) mg/dl, p < 0.001) and synovial fluid IL1 beta (8.0 (4.7) v 3.0 (3.0) pg/ml, p < 0.001) and IL6 (828.2 (492.6) v 469.3 (201.4) pg/ml, p < 0.005). No differences were found in the number of subjects with dactylitis, pitting oedema, HLA-B27, or signs of sacroiliac and sternoclavicular joint involvement at bone scintigraphy. After two years, progression was more evident in EOPsA than in YOPsA, as the number of new erosions in the hands and also the C reactive protein were higher in EOPsA patients.
  
  
  CONCLUSIONS
  PsA has a more severe onset and a more destructive outcome in elderly people (onset > 60 years) than in younger subjects. This behaviour may be influenced by immune changes associated with aging, as suggested by the higher concentrations of IL1 beta and IL6 found in the synovial fluid of EOPsA than in YOPsA.
authors.affiliation: Division of Rheumatology, University of Padova, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Punzi
authors.forename: M
authors.initials: M
authors.lastname: Pianon
authors.forename: P
authors.initials: P
authors.lastname: Rossini
authors.forename: F
authors.initials: F
authors.lastname: Schiavon
authors.forename: P F
authors.initials: PF
authors.lastname: Gambari
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000276:immunology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D016209:Interleukin-8 / Q000032:analysis; D007596:Joints / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013582:Synovial Fluid / Q000276:immunology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D002097:C-Reactive Protein