[Transthoracic defibrillation of cardiac ventricles: effects of novocainamide on effectiveness of an electric impulse of bipolar sinusoidal shape].
Experiments on nembutal-narcotized dogs were made to study dose effects of novocainamide (10-65 mg/kg) on threshold values of transthoracic defibrillation current of bipolar sinusoidal shape. Reversible dose-dependent increase of the threshold of ventricular defibrillation by 21%, on the average, was achieved only after novocainamide lowering of arterial pressure by 15-35 mm Hg. Coefficient of correlation between the drug dose and intensity of the efficient current made up 0.72.
Vostrikov
V A
VA
Bogushevich
M S
MS
Mikhaĭlov
I V
IV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004285:Dogs; D004554:Electric Countershock; D011342:Procainamide / Q000627:therapeutic use*; D013909:Thorax; D014693:Ventricular Fibrillation / Q000628:therapy*
D000889:Anti-Arrhythmia Agents; D011342:Procainamide
Transtorakal'naia defibrilliatsiia zheludochkov serdtsa: vliianie novokainamida na éffectivnost' élektricheskogo impul'sa bipoliarnoĭ sinusoidal'noĭ formy.