[The effects of IFN-gamma on the antitumor abilities of immunocytes and chemotherapeutic agents].
We studied the effects of IFN-gamma in immunotherapy and chemoimmunotherapy. The effects of IFN-gamma on TIL and LAK cytotoxicities on K562 tumor cell line and MKN45 gastric cancer tumor were observed. The antitumor effects of 5 chemotherapeutic agents with or without IFN-gamma on SGC7901 gastric cancer cell line were evaluated. The results showed that: (1) IFN-gamma obviously enhanced the cytotoxicities of TIL and LAK on 2 cell line: (2) IFN-gamma also increased the antitumor abilities of 5 agents on SGC7901 cell line. The study suggested that IFN-gamma is useful in immunotherapy and chemoimmunotherapy as an important immunomodulating agent.
Gu
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Department of Surgery, Shanghai Ruijin Hospital.
Zhu
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Z
Yin
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H
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D016219:Immunotherapy, Adoptive; D007371:Interferon-gamma / Q000494:pharmacology*; D020014:K562 Cells / Q000187:drug effects; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D011994:Recombinant Proteins; D013274:Stomach Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D011994:Recombinant Proteins; D007371:Interferon-gamma