Cogan's syndrome with refractory abdominal aortitis and mesenteric vasculitis.
Cogan's syndrome is a rare multisystem disease characterized by ocular inflammation, vestibuloauditory dysfunction, and vasculitis. We report a 26-year-old Caucasian woman who died from Cogan's syndrome. Her case illustrates that patients with Cogan's syndrome can have abdominal aortitis and mesenteric vasculitis, and that the vasculitis can be refractory to methotrexate, cyclophosphamide, cyclosporine, and chlorambucil.
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Department of Medicine, The Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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Hellmann
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D000328:Adult; D001025:Aortitis / Q000150:complications* / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications; D003639:Hearing Loss, Sudden / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007634:Keratitis / Q000150:complications / Q000188:drug therapy; D008643:Mesentery / Q000098:blood supply*; D013577:Syndrome; D014657:Vasculitis / Q000150:complications* / Q000188:drug therapy; D014717:Vertigo / Q000150:complications
D007166:Immunosuppressive Agents