title: Recent experiences with hexadimethrine for neutralizing heparin after cardiopulmonary bypass.
abstract: Hexadimethrine bromide was used for the neutralization of heparin during cardiac surgery in the late 1950s. For some years, this institution has used it for patients who may be allergic to protamine. In view of the recent renewal of interest in hexadimethrine, we present four cases outlining its use during cardiac procedures in such patients. Other drugs for reversing the action of heparin such as heparinase or platelet factor IV are not yet widely available.
authors.affiliation: Department of Anaesthesia, Royal Perth Hospital, Western Australia.
authors.forename: A
authors.initials: A
authors.lastname: Cooney
authors.forename: T J
authors.initials: TJ
authors.lastname: Mann
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006494:Heparin Antagonists / Q000627:therapeutic use*; D006583:Hexadimethrine Bromide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000009:adverse effects
chemical_list: D006494:Heparin Antagonists; D011479:Protamines; D006583:Hexadimethrine Bromide