title: Induction of presenilins in the rat brain after middle cerebral arterial occlusion.
abstract: In the present study, we have examined the expression of both presenilins in the rat hippocampus, cortex, striatum, and cerebellum after middle cerebral artery occlusion (MCA-O), an animal model of ischemia. The cortex showed the greatest increase in PS mRNA levels (7-10-fold) at 4 and 8 days posttreatment. Presenilin-1 (PS-1) levels in the contralateral cortex were significantly increased 1 day after MCA-O. In comparison, PS mRNA content was only modestly elevated in the hippocampus and striatum at 4 and 8 days after MCA-O (30-100% changes). Other Alzheimer's disease (AD)-related genes, amyloid precursor protein and apolipoprotein E, are induced in brain injury suggesting that these AD-related genes may well be components of a brain-injury response. Thus, a breakdown in this response via cerebrovascular disease and/or genetic mutation may contribute to AD pathology.
authors.affiliation: Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa 33612, USA. kpennypa@pharm1.med.usf.edu
authors.forename: K R
authors.initials: KR
authors.lastname: Pennypacker
authors.forename: H
authors.initials: H
authors.lastname: Hernandez
authors.forename: S
authors.initials: S
authors.lastname: Benkovic
authors.forename: D G
authors.initials: DG
authors.lastname: Morgan
authors.forename: A E
authors.initials: AE
authors.lastname: Willing
authors.forename: P R
authors.initials: PR
authors.lastname: Sanberg
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002536:Cerebral Arteries; D015870:Gene Expression / Q000502:physiology; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D053764:Presenilin-1; D053766:Presenilin-2; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008565:Membrane Proteins; D053764:Presenilin-1; D053766:Presenilin-2