CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice.
Leishmania major induces the rapid production of interleukin-4 (IL-4) in both susceptible BALB/c and resistant B10.D2 mice. In both strains, IL-4 is produced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen. The rapid production of IL-4 in B10.D2 mice does not confer susceptibility but results in increased parasite burdens.
Julia
V
V
Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France.
Glaichenhaus
N
N
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007113:Immunity, Innate; D015847:Interleukin-4 / Q000276:immunology* / Q000378:metabolism; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D015800:Protozoan Proteins / Q000276:immunology*
D000953:Antigens, Protozoan; D015800:Protozoan Proteins; C093139:LACK antigen, Leishmania; D015847:Interleukin-4