title: [Synthesis and antiproliferative activity of a novel N-acyl derivative of doxorubicin].
abstract: Doxorubicin was acylated with estrone 3-hemisuccinate. The modified derivative exhibited high antiproliferative activity in vitro toward cell cultures of the MCF-7 human mammary adenocarcinoma and HepG2 human hepatoma.
authors.affiliation: Institute of Biological Medicine, Moscow, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Shcherbakov
authors.forename: V M
authors.initials: VM
authors.lastname: Devichenskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Vorontsov
authors.forename: S L
authors.initials: SL
authors.lastname: Kuznetsov
authors.forename: L N
authors.initials: LN
authors.lastname: Kriukov
mesh_terms: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C120001:estrone-3-hemisuccinate-doxorubicin; D004317:Doxorubicin
vernacular_title: Sintez i antiproliferativnaia aktivnost' novogo N-atsil'nogo proizvodnogo doksorubitsina.