title: Cell cycle: driving the centrosome cycle.
abstract: Cyclin-dependent kinases (Cdks) control major transitions as cells pass through the cell cycle. It has recently been shown that centrosome duplication in vertebrates requires Cdk2 activity and can be driven solely by Cdk2-cyclin E complexes.
authors.affiliation: MCD Biology, University of Colorado-Boulder, Boulder, Colorado 80309-0347, USA.
authors.forename: M
authors.initials: M
authors.lastname: Winey
mesh_terms: D000818:Animals; D042846:CDC2-CDC28 Kinases; D002453:Cell Cycle / Q000502:physiology*; D018385:Centrosome / Q000502:physiology*; D019927:Cyclin E / Q000502:physiology; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology
chemical_list: D019927:Cyclin E; D017346:Protein Serine-Threonine Kinases; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases