[Increase in radiation resistance of an organism after administration of metabolic drug MR-33].
Original MP-33 metabolic drug has inductive action on intracellular levels of glutathione (GSH) and GSH-related enzymes (glutathione peroxidase-GPx, glutathione S-transferase-GST) of animals and human (liver, heart, erythrocytes). Treatment of Wistar male rats with MP-33 per os (6 mg/kg) 30 min before gamma-irradiation with a dose of 7 Gy results in 35% survival and increasing of mean life. In "mother-foetus" system the induction of intracellular level of GSH, GST and GPx by MP-33 leads to enhancement of foetus radioresistance. In contrast to MP-33 us of GSH (6 and 100 mg/kg) is not effective. Perspective of MP-33 us in relation to radioecological crisis is discussed.
Kalinina
E V
EV
Medical Research and Production Complex Biotics, Moscow.
Novichkova
M D
MD
Chirkova
E M
EM
Koppel'
M A
MA
Komissarova
I A
IA
D000016:Abnormalities, Radiation-Induced / Q000517:prevention & control; D000328:Adult; D000818:Animals; D004790:Enzyme Induction; D005260:Female; D005978:Glutathione / Q000096:biosynthesis; D005979:Glutathione Peroxidase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D006801:Humans; D008297:Male; D011247:Pregnancy; D011506:Proteins; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
C119710:MP-33; D011506:Proteins; D011837:Radiation-Protective Agents; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione
Povyshenie radiorezistentnosti organizma pri deĭstvii metabolitnogo preparata MR-33.