Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician.
At one time, the diagnosis of a deficiency of vitamin B12 or folate was considered to be relatively straightforward. As knowledge has accumulated, the limitations of such tests as serum vitamin level measurements and the Schilling test have become apparent. With the development of newer tests, atypical and subclinical deficiency states have been recognized. In this review, available tests used in the diagnosis of vitamin B12 and folate deficiency are discussed, and a rational approach to the diagnosis of these deficiency states is presented.
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Division of Primary Care, Santa Clara Valley Medical Center, San Jose, Calif., USA.
D000906:Antibodies / Q000097:blood; D019411:Clinical Laboratory Techniques; D002986:Clinical Trials as Topic; D003663:Decision Trees; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000378:metabolism; D005494:Folic Acid Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006402:Hematologic Diseases / Q000150:complications; D006710:Homocysteine / Q000097:blood / Q000652:urine; D006801:Humans; D007437:Intrinsic Factor / Q000276:immunology; D008764:Methylmalonic Acid / Q000097:blood / Q000652:urine; D009422:Nervous System Diseases / Q000209:etiology; D010295:Parietal Cells, Gastric / Q000276:immunology; D011320:Primary Health Care; D012546:Schilling Test; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
D000906:Antibodies; D006710:Homocysteine; D008764:Methylmalonic Acid; D007437:Intrinsic Factor; D014805:Vitamin B 12