title: Age, body mass index and 2-hour plasma glucose are the major determinants of blood pressure in Chinese women newly diagnosed to have glucose intolerance.
abstract: Hypertension and diabetes frequently coexist and greatly increase cardiovascular risk. There are relatively few data on the relationship between blood pressure and plasma glucose in newly diagnosed diabetic subjects especially in Chinese. We examined the glycaemic status, blood pressure profiles and other clinical and biochemical characteristics in 1298 Hong Kong Chinese women. These women were referred to the Diabetes and Endocrine Center of the Prince of Wales Hospital for screening of diabetes. The reasons for referral included a positive family history of diabetes or a history of gestational diabetes. Of the 1298 subjects, 836 (64.4%) had normal oral glucose tolerance test, 284 (21.9%) had impaired glucose tolerance and 178 (13.7%) had diabetes. Compared to non-diabetic subjects, the odds ratio (95% confidence interval) of having hypertension in subjects with impaired glucose tolerance or diabetes were 2.83 (1.90, 4.23) (P<0.001) and 5.94 (3.94, 8.96) (P<0.001), respectively. When analyzed as a continuous variable by age-adjusted partial correlation coefficients, systolic blood pressure was correlated with body mass index, fasting and 2-h plasma glucose, while diastolic blood pressure was correlated with body mass index. Using age, body mass index, fasting and 2-h plasma glucose, glycated hemoglobin, cholesterol, triglyceride and smoking as independent variables in multivariate analysis, hypertension was independently related to age, body mass index and 2-h plasma glucose. In conclusion, increased blood pressure was common in Hong Kong Chinese women who were newly diagnosed to have glucose intolerance. Apart from age and body mass index, plasma glucose was an independent determinant for blood pressure in these subjects.
authors.affiliation: Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Tai Po, Hong Kong.
authors.forename: G T
authors.initials: GT
authors.lastname: Ko
authors.forename: J C
authors.initials: JC
authors.lastname: Chan
authors.forename: C S
authors.initials: CS
authors.lastname: Cockram
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000208:ethnology*; D005951:Glucose Tolerance Test; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000208:ethnology*; D008875:Middle Aged; D015995:Prevalence; D012907:Smoking / Q000009:adverse effects; D013223:Statistics as Topic
chemical_list: D001786:Blood Glucose