title: [Primary HIV-infection: infectious mononucleosis-like presentation with treatment options].
abstract: Two patients, men aged 39 and 52 years, are described with a mononucleosis-like syndrome, due to a primary HIV infection. Both patient developed dermatological manifestations. One patient presented with an encephalitis with an inversed CD4/CD8 cell ratio in the cerebrospinal fluid. Primary HIV infection is often missed as a clinical diagnosis. The possible preservation of a strong cellular immune response against HIV itself in case of early start of treatment argues for an immediate intervention with a combination of antiretroviral drugs in this syndrome.
authors.affiliation: Academisch Ziekenhuis, afd. Algemene Interne Geneeskunde, Nijmegen.
authors.forename: K
authors.initials: K
authors.lastname: Brinkman
authors.forename: J M
authors.initials: JM
authors.lastname: Prins
authors.forename: S
authors.initials: S
authors.lastname: Jurriaans
authors.forename: J M
authors.initials: JM
authors.lastname: Lange
mesh_terms: D000208:Acute Disease; D000328:Adult; D016516:CD4-CD8 Ratio; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004485:Eczema / Q000175:diagnosis; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000302:isolation & purification*; D018451:Homosexuality, Male; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014777:Virus Diseases / Q000175:diagnosis
chemical_list: D017320:HIV Protease Inhibitors
vernacular_title: Primaire HIV-infectie: mononucleosis-infectiosa-achtig ziektebeeld met therapeutische mogelijkheden.