title: Transneuronal degeneration of retinal ganglion cells in early hemispherectomized monkeys.
abstract: Transneuronal retrograde cell changes in the retina of the primate have been well documented after lesions to striate cortex, but little is known about the effects of hemispherectomy, a surgical procedure used in humans for the treatment of intractable epilepsy. In order to follow the time course of this degenerative process, we examined the retinae of six monkeys who underwent a total hemispherectomy at various postnatal ages with a survival period of 4 years. We demonstrate that transneuronal retrograde degeneration in the retina following hemispherectomy is inversely correlated with age at the time of the lesion. This degeneration is maximal when the lesion is induced within the first 4-6 months of life and less pronounced from 8 months to adulthood.
authors.affiliation: Ecole d'Optométrie, Centre de Recherche en Sciences Neurologiques and Département de Psychologie, Université de Montréal, Que., Canada.
authors.forename: M
authors.initials: M
authors.lastname: Herbin
authors.forename: D
authors.initials: D
authors.lastname: Boire
authors.forename: H
authors.initials: H
authors.lastname: Théoret
authors.forename: M
authors.initials: M
authors.lastname: Ptito
mesh_terms: D000818:Animals; D001931:Brain Mapping; D002452:Cell Count; D002522:Chlorocebus aethiops; D007839:Functional Laterality; D008297:Male; D009410:Nerve Degeneration; D019635:Neurosurgical Procedures; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013997:Time Factors; D014793:Visual Cortex / Q000502:physiology*