Local inflammation may influence oral tumor cell differentiation.
The mRNA levels of keratin K13, involucrin, protein kinase C alpha and epsilon, and interferon-gamma and its receptors were examined in biopsies from human oral squamous cell carcinomas. Expression of all the genes was elevated in the histologically more differentiated tumors, but it was at or below normal (perilesional control) levels in the poorly differentiated ones. For the same set of biopsies, we had previously shown that the well differentiated tumors expressed higher levels of T cell markers. As interferon-gamma stimulates differentiation, its secretion by inflammatory cells at the tumor site may influence the differentiation status of the tumor.
Arany
I
I
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555, USA.
Adler-Storthz
K
K
Chen
Z
Z
Tyring
S K
SK
Brysk
H
H
Lei
G
G
Brysk
M M
MM
D002454:Cell Differentiation; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D007633:Keratins / Q000032:analysis / Q000235:genetics; D009062:Mouth Neoplasms / Q000473:pathology*; D011493:Protein Kinase C / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D007633:Keratins; D007371:Interferon-gamma; D011493:Protein Kinase C