title: Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients.
abstract: The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gene polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.
authors.affiliation: Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: F L
authors.initials: FL
authors.lastname: Sciacca
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: K
authors.initials: K
authors.lastname: Vandenbroeck
authors.forename: F
authors.initials: F
authors.lastname: Veglia
authors.forename: C
authors.initials: C
authors.lastname: Gobbi
authors.forename: F
authors.initials: F
authors.lastname: Martinelli
authors.forename: D
authors.initials: D
authors.lastname: Franciotta
authors.forename: M
authors.initials: M
authors.lastname: Zaffaroni
authors.forename: M
authors.initials: M
authors.lastname: Marrosu
authors.forename: G
authors.initials: G
authors.lastname: Martino
authors.forename: V
authors.initials: V
authors.lastname: Martinelli
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: N
authors.initials: N
authors.lastname: Canal
authors.forename: L M
authors.initials: LM
authors.lastname: Grimaldi
mesh_terms: D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns; D007558:Italy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*
chemical_list: D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D004247:DNA