The trithorax-group and polycomb-group chromatin modifiers: implications for disease.
The chromatin structure associated transcriptional memory function by Polycomb-group and trithorax-group protein complexes integrate normal development with control of cellular proliferation. This is illustrated by recent mechanistic insights that link Polycomb repression with histone deacetylases and the identification of new target genes that provide a connection to cell cycle control and tumorigenesis.
van Lohuizen
M
M
The Netherlands Cancer Institute Department of Molecular Carcinogenesis Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. Lohuizen@NKI.NL
D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D007938:Leukemia / Q000235:genetics*; D063150:Polycomb Repressive Complex 1; D014157:Transcription Factors
D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C066770:Pc protein, Drosophila; D014157:Transcription Factors; C063460:Trl protein, Drosophila; D063150:Polycomb Repressive Complex 1