title: Local intramural heparin delivery during primary angioplasty for acute myocardial infarction: results of the Local PAMI Pilot Study.
abstract: The feasibility and safety of local heparin delivery during acute infarct angioplasty was evaluated in a prospective, multicenter, 120-patient series. Angioplasty was performed using standard techniques, after which heparin (4,000 U) was delivered locally; 25% of patients received stents. Procedural success was reported in 98% of patients; 6.7% of patients suffered death, reinfarction, recurrent ischemia, or stroke during the index hospitalization. The 6-month target vessel revascularization rate was 12.5%. Local heparin therapy with provisional stenting in acute myocardial infarction patients is safe, feasible, associated with a low rate of infarct artery revascularization at 6 months, and may potentially eliminate the need for systemic heparin following the procedure.
authors.affiliation: Department of Cardiology, St. Joseph's Hospital, Syracuse, New York, USA.
authors.forename: P
authors.initials: P
authors.lastname: Esente
authors.forename: A V
authors.initials: AV
authors.lastname: Kaplan
authors.forename: J K
authors.initials: JK
authors.lastname: Ford
authors.forename: J L
authors.initials: JL
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Ayres
authors.forename: E J
authors.initials: EJ
authors.lastname: Kosinski
authors.forename: D M
authors.initials: DM
authors.lastname: Lasorda
authors.forename: M
authors.initials: M
authors.lastname: Graham
authors.forename: P
authors.initials: P
authors.lastname: Gallant
authors.forename: L L
authors.initials: LL
authors.lastname: Grines
authors.forename: C L
authors.initials: CL
authors.lastname: Grines
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D005240:Feasibility Studies; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D010865:Pilot Projects; D011446:Prospective Studies; D015607:Stents; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin