A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp.
A new cytotoxic substance was isolated following acid treatment of fermented broth of a Streptomyces strain numbered MJ915-WF12. The structure was elucidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.
Nosaka
C
C
Institute of Microbial Chemistry, Tokyo, Japan.
Kunimoto
S
S
Masuda
T
T
Ohsono
M
M
Iinuma
H
H
Tsuchida
T
T
Hamada
M
M
Takeuchi
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D051379:Mice; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
C120458:5,5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran; D000970:Antineoplastic Agents; D003470:Culture Media; D011714:Pyrans