[Comparison of changes in oncogene of human embryo lung cells before and after chemical modification for chrysotile].
OBJECTIVE
To seek for a suitable chamical agent for surface modification of chrysotile.


METHODS
The effects of aluminum citrate, mixed rare earth and sodium selenite on c-Ha-ras oncogene and P21ras protein in the transformation of human embryo lung cells caused by chrysotile were studied.


RESULTS
The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile were significantly higher than those in the controls. The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile treated in advance with three kinds of chemicals mentioned above were significantly lower than those in untreated.


CONCLUSIONS
Treatment of chrysotile with three kinds of above-mentioned chemicals in advance could reduce its carcinogenecity in human beings.
Fan
J
J
National Institute of Occupational Safety and Health, Beijing.
Wang
Q
Q
Liu
S
S
D017607:Aluminum Compounds; D017632:Asbestos, Serpentine / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D004347:Drug Interactions; D004622:Embryo, Mammalian; D011905:Genes, ras; D006801:Humans; D008168:Lung / Q000166:cytology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*; D018038:Sodium Selenite
D017607:Aluminum Compounds; D017632:Asbestos, Serpentine; D002273:Carcinogens; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D018038:Sodium Selenite