title: C-erbB-2 immunostaining in laryngeal cancer.
abstract: Tumour progression is strongly associated with a series of specific genetic changes in protooncogenes and tumour suppressor genes. One of the potential factors involved in tumorogenesis of squamous cell carcinomas is protooncogene c-erbB-2 (also known as neu or HER2). The authors analysed the expression of c-erbB-2 oncoprotein in 154 cases of laryngeal squamous cell carcinomas and its relationship to the clinical outcome of the patients. The difference in c-erbB-2 oncoprotein expression between the control group and cancer patients was on the statistical borderline (p = 0.0470). There was no significant correlation between c-erbB-2 expression and sex and age of the patients. T stage, lymph node status, site and histopathological grading of the tumour and clinical outcome of the patients. Univariate analysis revealed no correlation between c-erbB-2 expression and survival rates. We conclude that immunohistological examination of c-erbB-2 on paraffin section is not a valuable prognostic factor in laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology--Head and Neck Surgery, Medical University, Wrocław, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Krecicki
authors.forename: M
authors.initials: M
authors.lastname: Jeleń
authors.forename: M
authors.initials: M
authors.lastname: Zalesska-Krecicka
mesh_terms: D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D018734:Genes, erbB-2 / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017354:Point Mutation / Q000235:genetics; D012189:Retrospective Studies