Biophysical shunt theory for neuropsychopathology: pentaphasic lipid-induced model for schizophrenia.
We propose a five-phase model for schizophrenia: (A) Imperfect diet-induced fatty acid combinations are mobilized from reservoirs during stress exposure into the bloodstream; (B) Increased brain-blood barrier permeability, with a further penetration of fat into the brain matter; (C) Rearrangement in the regional neuronal membrane fatty acids with a further physical compression of the adjacent membrane protein structures causing conformational alterations; (D) Cytokines generate further physical changes, impairing single- or multi-dispersed ion channels placed on the same neuron; (E) Ion channels are blocked, with a subsequent biophysical ion shunt-to-ion flow propagation, which results in neuronal misfiring and the appearance of schizophrenic signs and symptoms.
Naisberg
Y
Y
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.
Weizman
A
A
D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D008954:Models, Biological; D008960:Models, Psychological; D009446:Neurobiology; D009484:Neuropsychology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology