title: Müller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis.
abstract: Poorly recognized by anatomists and pathologists is the cone-shaped zone of Müller cells that composes the central and inner part of the fovea centralis. The importance of these cells in the structural integrity of the macula, as a repository for xanthophyll, and in the pathogenesis of macular diseases, particularly regarding idiopathic macular hole and foveomacular schisis, is hypothesized.
authors.affiliation: Department of Ophthalmology, Vanderbilt University, Nashville, Tenn 37232-8808, USA. Donald.Gass@mcmail.vanderbilt.edu
authors.forename: J D
authors.initials: JD
authors.lastname: Gass
mesh_terms: D005260:Female; D005584:Fovea Centralis / Q000648:ultrastructure*; D006801:Humans; D014975:Lutein / Q000378:metabolism; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology*; D010684:Philosophy; D012162:Retinal Degeneration / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D012167:Retinal Perforations / Q000209:etiology* / Q000378:metabolism / Q000473:pathology
chemical_list: D014975:Lutein