title: Human herpes virus-6 seroprevalence and leukaemias: a case-control study. GIMEMA (Gruppo Italiano Malattie Ematologiche dell' Adulto).
abstract: The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multicentre case-control study. An association between increased HHV-6 seropositivity and geometric mean titre ratio with AML was shown: P for trend = 0.022, adjusted odds ratio 1.20, 95% confidence interval 1.07-1.33 respectively. No association was found between HHV-6 and ALL, CML or RAEB.
authors.affiliation: Dipartimento di Biotecnologie Cellulari e Ematologia, Università La Sapienza, Roma, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Gentile
authors.forename: A
authors.initials: A
authors.lastname: Mele
authors.forename: G
authors.initials: G
authors.lastname: Ragona
authors.forename: A
authors.initials: A
authors.lastname: Faggioni
authors.forename: C
authors.initials: C
authors.lastname: Zompetta
authors.forename: M E
authors.initials: ME
authors.lastname: Tosti
authors.forename: G
authors.initials: G
authors.lastname: Visani
authors.forename: G
authors.initials: G
authors.lastname: Castelli
authors.forename: A
authors.initials: A
authors.lastname: Pulsoni
authors.forename: B
authors.initials: B
authors.lastname: Monarca
authors.forename: P
authors.initials: P
authors.lastname: Martino
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000453:epidemiology* / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology* / Q000821:virology; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000821:virology; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral