Methodology for pharmacokinetic/pharmacodynamic data analysis.
This review will highlight the role of exploratory data analysis and nonlinear regression software in pharmacokinetic-pharmacodynamic (PK/PD) data analysis. Kinetic and dynamic modelling situations typical to the pharmacokineticist in the drug industry will be addressed, and two case studies, including single-dose intravenous bolus plasma data and multiple-dose response-time data will be analysed. Approaches to assessing the suitability of model fit to the observed data will be discussed, and a summary of the key features of available commercial PK software will be given. Specific emphasis will be placed on the application of WinNonlin.
Gabrielsson
JL
Department of Drug Metabolism and Pharmacokinetics, Astra Arcus AB, S-151 85 Södertälje, Sweden.
Weiner
DL