title: Transfer RNA modification: influence on translational frameshifting and metabolism.
abstract: Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.
authors.affiliation: Department of Microbiology, Umeå University, Sweden. glenn.bjork@micro.umu.se
authors.forename: G R
authors.initials: GR
authors.lastname: Björk
authors.forename: J M
authors.initials: JM
authors.lastname: Durand
authors.forename: T G
authors.initials: TG
authors.lastname: Hagervall
authors.forename: R
authors.initials: R
authors.lastname: Leipuviene
authors.forename: H K
authors.initials: HK
authors.lastname: Lundgren
authors.forename: K
authors.initials: K
authors.lastname: Nilsson
authors.forename: P
authors.initials: P
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Qian
authors.forename: J
authors.initials: J
authors.lastname: Urbonavicius
mesh_terms: D018965:Frameshifting, Ribosomal / Q000235:genetics / Q000502:physiology*; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism*
chemical_list: D012329:RNA, Bacterial; D012343:RNA, Transfer