title: Idiopathic blepharospasm does not lead to a parkinsonian syndrome: results of a questionnaire-based follow-up study.
abstract: It has been suggested that a lesion in the dopaminergic neurons of the substantia nigra pars compacta combined with eye irritation is involved in the pathophysiology of idiopathic blepharospasm. If so, these patients might be prone to develop Parkinson's disease or a parkinsonian syndrome. We therefore conducted a validated questionnaire-based follow-up study to estimate (a) the frequency of local eye disorders at onset and (b) frequency of development of parkinsonian symptoms in blepharospasm patients. Ninety-nine patients previously diagnosed with idiopathic blepharospasm were sent a two-part questionnaire to assess parkinsonian and other symptoms associated with their condition. The average period of follow-up was 12.7 years, ranging from 3 to 26 years, with an average age at onset of 53.5 years. Sixty-two patients reported other ocular symptoms prior to or at the onset of blepharospasm, and therefore ocular disease may act as a trigger to produce blepharospasm in those already predisposed. Only two patients had developed a score on the parkinsonism rating scale indicating possible Parkinson's disease, but clinical examination confirmed this not to be the case. If a lesion in the dopaminergic neurons is involved in blepharospasm, it would appear to be relatively minor (and non-progressive), since patients with idiopathic blepharospasm do not seem prone to develop parkinsonian symptoms.
authors.affiliation: University Department of Clinical Neurology, Institute of Neurology, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Soonawala
authors.forename: K P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: J H
authors.initials: JH
authors.lastname: Yeung
authors.forename: N P
authors.initials: NP
authors.lastname: Quinn
authors.forename: C D
authors.initials: CD
authors.lastname: Marsden
mesh_terms: D000368:Aged; D001764:Blepharospasm / Q000150:complications*; D004421:Dystonia; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000209:etiology*; D011954:Receptors, Dopamine / Q000502:physiology; D012307:Risk Factors; D013378:Substantia Nigra / Q000473:pathology*; D011795:Surveys and Questionnaires
chemical_list: D011954:Receptors, Dopamine