title: Effects of indomethacin on joint damage in rat and rabbit.
abstract: OBJECTIVE
  To study the effects of indometacin (Ind) on joint damages.
  
  
  METHODS
  The volume of noninjected hind paw and interleukin-1 (IL-1) production from peritoneal macrophages and articular synoviocytes induced by lipopolysaccharides were assayed in adjuvant arthritis (AA) rats. Measurements of synovial fibroblast proliferative response and proteoglycan synthesis of cartilage from rabbits were used.
  
  
  RESULTS
  The secondary inflammatory reactions in AA rats on d 18, 21, and 24 were suppressed by i.g. Ind 2 mg.kg-1.d-1 for 9 d. Ind promoted IL-1 production from both macrophages and synoviocytes in AA rats. Ind 10 mumol.L-1 enhanced the proliferation of rabbit synovial fibroblasts and suppressed the proteoglycan synthesis of articular cartilage in response to IL-1 in vitro.
  
  
  CONCLUSIONS
  Ind is unfavorable to the repair of joint destruction.
authors.affiliation: Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Y Y
authors.initials: YY
authors.lastname: Yao
authors.forename: M Z
authors.initials: MZ
authors.lastname: Chen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D007213:Indomethacin / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D017737:Macrophages, Peritoneal / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011509:Proteoglycans / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D011509:Proteoglycans; D007213:Indomethacin