[Radiation protective agents effective in a wide range of radiation dosages].
Perspective chemical classes of prophylactic radioprotecting compounds were found from analysis of proper experimental data. Preparations effective in a wide range of radiation doses of various intensity were synthesized. Their activity are due to combination of antiradiation and many other pharmacological properties. During acute radiation these preparations protect stem cells pul of critical tissues but under prolonged radiation they normalize the hematological, immune and lipid peroxide oxidation systems. There is no strong correlation between radioprotection and increasing of functional reserve of organism.
Rasina
L N
LN
Institute of Organic Synthesis, Ural Branch Russian Academy of Sciences, Ekaterinburg.
Chupakhin
O N
ON
D000818:Animals; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents
Protivoluchevye preparaty, éffektivnye v bol'shom diapazone doz oblucheniia.