Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients.
The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gene polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.
Sciacca
F L
FL
Neuroimmunology Unit, San Raffaele Scientific Institute, Milan, Italy.
Ferri
C
C
Vandenbroeck
K
K
Veglia
F
F
Gobbi
C
C
Martinelli
F
F
Franciotta
D
D
Zaffaroni
M
M
Marrosu
M
M
Martino
G
G
Martinelli
V
V
Comi
G
G
Canal
N
N
Grimaldi
L M
LM
D000328:Adult; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007438:Introns; D007558:Italy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000032:analysis; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*
D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D004247:DNA