Absence of effect of stimulants on the phamacokinetics of desipramine in children.
We conducted a retrospective chart review to examine the pharmacokinetic interaction between desipramine and the stimulants methylphenidate and dexedrine using routinely monitored desipramine serum concentrations in children receiving desipramine either alone or with a stimulant. Subjects were 142 children and adolescents (age 6-17 yrs; 113 taking desipramine, 29 taking desipramine-stimulants) in whom 401 dose- and weight-normalized serum concentrations were evaluated (333 desipramine, 68 desipramine-stimulants). Desipramine pharmacokinetic parameters were similar for both groups, including mean weight-corrected dose (3.66+/-1.36 mg/kg, desipramine; 3.66+/-1.09 mg/kg, desipramine-stimulants; p=0.97), weight- and dose-normalized serum concentrations (47.26+/-39.26 [microg/L]/[mg/kg], desipramine, 39.02+/-19.92 [microg/L]/[mg/kg], desipramine-stimulants; p=0.09), and clearance (0.690+/-0.913 [L/kg]/hr, desipramine; 0.613+/-0.514 [L/kg]/hr, desipramine-stimulants; p=0.499). When stratified by age, gender, and type of stimulant, no difference was detected (p>0.05) between groups. Our findings indicate the absence of a clinically significant interaction between desipramine and stimulants.
Cohen
L G
LG
Department of Psychiatry Pharmacy, Massachusetts General Hospital, Harvard Medical School, Boston 02114-3139, USA.
Prince
J
J
Biederman
J
J
Wilens
T
T
Faraone
S V
SV
Whitt
S
S
Mick
E
E
Spencer
T
T
Meyer
M C
MC
Polisner
D
D
Flood
J G
JG
D000293:Adolescent; D000929:Antidepressive Agents, Tricyclic / Q000493:pharmacokinetics*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002648:Child; D003891:Desipramine / Q000493:pharmacokinetics*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008774:Methylphenidate / Q000494:pharmacology*; D012189:Retrospective Studies
D000929:Antidepressive Agents, Tricyclic; D000697:Central Nervous System Stimulants; D008774:Methylphenidate; D003891:Desipramine; D003913:Dextroamphetamine