IPD-1151T (suplatast tosilate) inhibits interleukin (IL)-13 release but not IL-4 release from basophils.
The effect of suplatast tosilate (IPD-1151T), which is known to suppress interleukin (IL)-4 release from T cells, on the release of IL-4 and IL-13 from human peripheral basophils was investigated. Basophils were obtained from 16 mite-sensitive atopic asthmatic patients. IPD-1151T clearly inhibited the antigen-induced release of IL-13 but not IL-4. These results suggest that IPD-1151T possesses different activity for the regulation of cytokine release in basophils and T cells.
Shichijo
M
M
Department of Pharmacology, Gifu Pharmaceutical University, Japan.
Shimizu
Y
Y
Hiramatsu
K
K
Togawa
M
M
Inagaki
N
N
Takagi
K
K
Nagai
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001190:Arylsulfonates / Q000494:pharmacology*; D001249:Asthma / Q000097:blood / Q000276:immunology; D001491:Basophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D018793:Interleukin-13 / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D013452:Sulfonium Compounds / Q000494:pharmacology*
D018926:Anti-Allergic Agents; D001190:Arylsulfonates; D018793:Interleukin-13; D013452:Sulfonium Compounds; D015847:Interleukin-4; C073028:suplatast tosilate