[Measurement of urinary content of lactulose and mannitol by gas chromatography as an index of permeability of the gut].
We established lactulose-mannitol(L-M) measurement method by gas chromatography and 9202 computer data processing system to test intestinal permeability. The urine output of L-M was in linear correlation to its sample concentration within working range. In an animal model of acute pancreatitis, lactulosesecretion increased in urine, together with increased L/M ratio. The measurement of lactulose-mannitol intestinal permeability by our method might serve as a predictor for early diagnosis of endogenous infection and sepsis.
Zhu
X
X
304th Hospital of People's Liberation Army, Beijing.
Xiong
D
D
Sheng
Z
Z
D000818:Animals; D002056:Burns / Q000652:urine; D002199:Capillary Permeability; D002849:Chromatography, Gas; D004285:Dogs; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000493:pharmacokinetics* / Q000652:urine; D008353:Mannitol / Q000493:pharmacokinetics* / Q000652:urine; D010195:Pancreatitis / Q000652:urine; D013552:Swine
D008353:Mannitol; D007792:Lactulose