title: Effects of graded suppression of the EEG with propofol on the neurological outcome following incomplete cerebral ischaemia in rats.
abstract: We evaluated the relation between dose and response for the neuroprotective effect of propofol in a rat model with incomplete cerebral ischaemia. For clarification of the mechanism of neuroprotection, plasma catecholamines and tumour necrosis factor-alpha levels were measured. Three doses (low, moderate and high-dose) of propofol were tested. These produced, respectively, a low amplitude, slowing and a burst-suppression pattern of electroencephalographic activity. Incomplete cerebral ischaemia was produced by right carotid artery occlusion combined with haemorrhagic hypotension (35 mmHg) for 30 min. Neurological outcome at 72 h post-ischaemia in the high-dose group was significantly better than that in both low-dose and moderate-dose groups. Propofol exhibited a trend in the dose-related attenuation of the increases in plasma adrenaline and noradrenaline during ischaemia. Tumour necrosis factor-alpha increased during and after ischaemia in all groups with no intergroup differences. The results indicate that a burst-suppression dose of propofol provides neuroprotection. The protective effect can not be completely explained by the attenuating effect on circulating catecholamines.
authors.affiliation: Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Nakakimura
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: L
authors.initials: L
authors.lastname: Xiong
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Sakabe
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000818:Animals; D002545:Brain Ischemia / Q000097:blood / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D008297:Male; D009043:Motor Activity; D009638:Norepinephrine / Q000097:blood; D010147:Pain Measurement; D015742:Propofol / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D018686:Anesthetics, Intravenous; D014409:Tumor Necrosis Factor-alpha; D009638:Norepinephrine; D015742:Propofol; D004837:Epinephrine