[Evaluation of radioprotective properties of a lipocarotenoid extract from mycelium of basidiomycetes during external irradiation].
Radioprotective properties of LPC extract from mycelium of Basidiomycetes fungus at doses 12.0; 3.0 and 1.0 Gy of external irradiation were investigated. The extract of LPC at 2.5 mkg/ml concentration promoted the survival of animals (to 40%) and increased the average life at the lethal dose. At 1.0 Gy dose the use of extract resulted in restoration of radiosensitive organs weights, the number of blood leucocytes and some indexes of lipid peroxidation in blood plasma. The extract has produced some effect on the amount of spermatogenic cells in the testis.
Konoplia
E F
EF
Institute of Radiobiology National Academy of Sciences of Belarus, Minsk.
Kapich
A N
AN
Vereshchako
G G
GG
Khodosovskaia
A M
AM
Rutkovskaia
Zh A
ZhA
Gvozdkova
T S
TS
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002338:Carotenoids / Q000302:isolation & purification / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013076:Sperm Count / Q000187:drug effects / Q000528:radiation effects
D011837:Radiation-Protective Agents; D002338:Carotenoids; D008315:Malondialdehyde
Otsenka radiozashchitnykh svoĭstv lipokarotinoidnogo ékstrakta iz mitseliia bazodial'nogo griba v usloviiakh vneshnego oblucheniia.