[Transporter and neurological disease].
There are two types of neurotransmitter transporters whose structure is known. One is a glutamate transporter family. The glutamate transporter takes up glutamate to terminate neurotransmission and to prevent neuronal cell death. The transporter may play important roles of cause and development in the neurological diseases. Another type is a catecholamine transporter family with 12 transmembrane domains. Dopamine transporter of the family takes up 1-methyl-4-phenylpyridinium (MPP+) and causes dopaminergic cell death.
Kawakami
H
H
Third Department of Internal Medicine, Hiroshima University School of Medicine.
D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D027322:Amino Acid Transport System X-AG; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D016923:Cell Death; D050483:Dopamine Plasma Membrane Transport Proteins; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019636:Neurodegenerative Diseases / Q000209:etiology*; D009474:Neurons / Q000502:physiology
D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins