title: Effects of anxiogenic drugs in rat forced swimming test.
abstract: The effect of antidepressants and anxiogenics in the forced swimming (Porsolt') test was investigated in rats. On the second day of an experiment, desipramine (10 mg/kg), pentylenetetrazole (20 mg/kg), picrotoxin (2.5 mg/kg), and clonidine (1.0 mg/kg) shortened while buspirone (1.0 mg/kg), yohimbine (2.5 mg/kg), DMCM (1.0 mg/kg), and Ro-15-4513 (1.0 mg/kg) prolonged the time of immobility or behavioral despair; fluoxetine (10 and 20 mg/kg), citalopram (10 mg/kg), and flumazenil (10 mg/kg) were ineffective. While clonidine, given in a subeffective dose (0.1 mg/kg), augmented the effect of desipramine (10 mg/kg), buspirone (1.0 mg/kg) had an opposite effect. The picrotoxin (2.5 mg/kg) challenge prominently shortened the time of immobility after desipramine (10 mg/kg) or citalopram (10 mg/kg) treatment. In conclusion, our results indicate that pharmacologically enhanced anxiety interacts with the effects of acute drug treatment in the forced swimming test.
authors.affiliation: Department of Pharmacology, University of Tartu, Estonia.
authors.forename: T
authors.initials: T
authors.lastname: Skrebuhhova
authors.forename: L
authors.initials: L
authors.lastname: Allikmets
authors.forename: V
authors.initials: V
authors.lastname: Matto
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D004357:Drug Synergism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013550:Swimming / Q000502:physiology*; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents