A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.
The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.
Dubljevic
V
V
Department of Pathology and Immunology, Monash Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia.
Sali
A
A
Goding
J W
JW
D000469:Alkaline Phosphatase / Q000235:genetics; D000595:Amino Acid Sequence; D017124:Conserved Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides; D011485:Protein Binding; D011990:Receptors, Transferrin / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014168:Transferrin / Q000378:metabolism*
D009842:Oligopeptides; D011990:Receptors, Transferrin; D011993:Recombinant Fusion Proteins; D014168:Transferrin; C047981:arginyl-glycyl-aspartic acid; D000469:Alkaline Phosphatase