Recurrent cardiocirculatory arrest after kidney transplantation related to intravenous methylprednisolone bolus therapy.
BACKGROUND
Intravenous bolus therapy with steroids is often used in standard immunosuppression initially after organ transplantation and to treat acute graft rejection. Although this regimen in generally is safe, severe adverse effects can occur.


METHODS
This letter gives a picture of the eventful clinical course of a patient with preexisting heard problems after renal transplantation.


RESULTS
This case report proves lethal cardiopulmonary complications closely related to the recurrent intravenous administration of methylprednisolone in a risk patient.


CONCLUSIONS
Severe side effects after the application of high-dose steroids are possible. If risk patients are identified, steroid bolus therapy should be avoided or, if not possible, should only be done under close monitoring.
Schult
M
M
Löhmann
D
D
Knitsch
W
W
Kuse
E R
ER
Nashan
B
B
D006084:Graft Rejection / Q000517:prevention & control; D006323:Heart Arrest / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007275:Injections, Intravenous; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use*; D008875:Middle Aged
D007166:Immunosuppressive Agents; D008775:Methylprednisolone