title: Recurrent multifocal demyelinating neuropathy with febrile illness and IgG subset deficiency.
abstract: We describe a unique syndrome of recurrent multifocal demyelinating motor greater than sensory deficits in cranial and peripheral nerve distributions with rapid, spontaneous improvement. Three patients presented with episodes over a period of 7 to 24 years, largely accompanied by febrile illness. Variably decreased IgG1 and IgG3 subclass levels were found. We postulate an immune-mediated process based upon the clinical presentation and presence of decreased IgG subclass levels.
authors.affiliation: Department of Neurology, University of Washington, Seattle 98195, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Likosky
authors.forename: E E
authors.initials: EE
authors.lastname: Kraus
authors.forename: E C
authors.initials: EC
authors.lastname: Yuen
mesh_terms: D000368:Aged; D003711:Demyelinating Diseases / Q000276:immunology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013577:Syndrome
chemical_list: D007074:Immunoglobulin G