Apoptosis of T lymphocytes in acute disseminated encephalomyelitis.
Apoptosis has been shown to be an efficient mechanism involved in clearance of T lymphocytes from the brains of animals with acute experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple sclerosis. In this report we describe a case of acute disseminated encephalomyelitis following general measles infection. In this disease, which closely mimics the pathology of acute EAE we found a high percentage (30%) of apoptotic T cells. This indicates that in both rodent and human brain clearance of T cell-mediated inflammation follows similar mechanisms.
Bauer
J
J
Institute of Neurology, University of Vienna, Austria.
Stadelmann
C
C
Bancher
C
C
Jellinger
K
K
Lassmann
H
H
D000293:Adolescent; D017209:Apoptosis; D053938:DNA Fragmentation; D004673:Encephalomyelitis, Acute Disseminated / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D013601:T-Lymphocytes / Q000473:pathology*