Synthesis and cytotoxic activity of 1-alkoxy- and 1-amino-2-hydroxy-1,2-dihydroacronycine derivatives.
Sixteen new derivatives of the natural alkaloid acronycine, bearing 1-alkoxy or 1-amino and 2-hydroxy groups, were synthesized in order to clarify the role of the C-1 substitution. Studies on the cytotoxic activity of compounds 4-19 were carried out in vitro on L-1210 cells. Structure-activity relationships are discussed.
Magiatis
P
P
Laboratory of Pharmacognosy, University of Athens, Greece.
Mitaku
S
S
Skaltsounis
A L
AL
Tillequin
F
F
Koch
M
M
Pierré
A
A
Atassi
G
G
D000175:Acronine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D013778:Tetrazolium Salts; D013844:Thiazoles
D000970:Antineoplastic Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue; D000175:Acronine