Splenic and hepatic hemozoin in mice after malaria parasite clearance.
Hemozoin (malaria pigment) is found in many tissues during malaria infections. In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. However, both spleen hemozoin concentration and total hemozoin content increased dramatically during this time period. Thus, hemozoin or hemozoin-laden macrophages continue to accumulate in murine spleens for at least several months after malaria parasitemia becomes undetectable.
Levesque
M A
MA
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA.
Sullivan
A D
AD
Meshnick
S R
SR
D000818:Animals; D006420:Hemeproteins / Q000032:analysis*; D008099:Liver / Q000737:chemistry* / Q000473:pathology; D008288:Malaria / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size; D010860:Pigments, Biological / Q000032:analysis; D016788:Plasmodium chabaudi / Q000502:physiology*; D010967:Plasmodium yoelii / Q000502:physiology*; D013154:Spleen / Q000737:chemistry* / Q000473:pathology
D006420:Hemeproteins; D010860:Pigments, Biological; C020753:hemozoin