title: Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs.
abstract: OBJECTIVE
  To study the pharmacokinetic behavior of 5-fluorouracil (5-FU) in pancreatic juice in dogs and its correlation with 5-FU in plasma, and to evaluate its penetration characteristics.
  
  
  METHODS
  After placing a pancreatico-drainage tube, 8 dogs were injected 5-FU 250 mg i.v. Blood and pancreatic samples were collected and the 5-FU concentrations were determined by HPLC. The pharmacokinetic parameters were obtained with statistical analysis.
  
  
  RESULTS
  The mean slopes of the terminal phase (K10) in plasma and pancreatic juice were 9.4 h-1 and 10.2 h-1, respectively (P > 0.05). The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model. Its penetration index was 3.39 +/- 2.84. The penetration of 5-FU from blood to pancreatic juice was relatively rapid, demonstrating a consistently higher concentration in pancreatic juice than in plasma.
  
  
  CONCLUSIONS
  The elimination phase of 5-FU in plasma was similar to that in pancreatic juice, indicating that they were in the same kinetic compartment.
authors.affiliation: Department of Pharmacy, Peking Union Medical College Hospital, PUMC, Chinese Academy of Medical Sciences, Beijing, China. cprzhuz@public.bta.net.cn
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
authors.forename: Q
authors.initials: Q
authors.lastname: Fu
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhao
authors.forename: Q
authors.initials: Q
authors.lastname: Liao
authors.forename: H N
authors.initials: HN
authors.lastname: Wang
authors.forename: C Q
authors.initials: CQ
authors.lastname: Xue
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Yang
authors.forename: D K
authors.initials: DK
authors.lastname: Li
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010189:Pancreatic Juice / Q000378:metabolism*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil