Insulin secretion: feed-forward control of insulin biosynthesis?
It has long been accepted wisdom that insulin secreted from islet beta cells has either no effect, or an inhibitory feedback effect, on insulin synthesis and secretion. Recent work suggests, instead, that secreted insulin acts directly on beta cells, via its own receptor, to enhance insulin production in an autocrine feed-forward loop.
Rutter
G A
GA
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. g.a.rutter@bris.ac.uk
D000818:Animals; D005246:Feedback; D015870:Gene Expression / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D011384:Proinsulin / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism
D007328:Insulin; D011498:Protein Precursors; C013737:preproinsulin; D011384:Proinsulin; D011972:Receptor, Insulin; D005947:Glucose