[An in vitro study on toxic effect of vanadium-titanium-magnetite dust on alveolar macrophage in rabbits].
OBJECTIVE
To study the toxic effect of vanadium-titanium-magnetite (VTM) dust on alveolar macrophage (AM) and its hazardous extent.


METHODS
Survival rates, morphology and function of AM were compared in rabbits exposed to dust of VTM, vanadium oxide, titanium dioxide and silica in various doses and length of time with in vitro cell culture and putamen membrane cover glass transmission electron microscopy, and changes in activities of lactic dehydrogenase (LDH) and acid phosphatase (ACP) in cell culture were measured.


RESULTS
Exposure to all the four kinds of dust could lead to decrease in survival rate of AM, increase in activities of LDH and ACP in the cell culture, and changes in their morphology and function to the extent dependent on the nature of dust.


CONCLUSIONS
Toxic effect of exposure to VTM dust was lower than that to vanadium oxide and silica, but higher than that to titanium dioxide, which had slight toxic effect.
Song
Y
Y
Institute for Industrial Hygiene and Protection, Panzhihua Iron and Steel (Group) Co., Sichuan.
Chen
Q
Q
Guan
Y
Y
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004391:Dust; D007501:Iron / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D014025:Titanium / Q000633:toxicity*; D017968:Vanadium Compounds / Q000633:toxicity*
D004391:Dust; D017968:Vanadium Compounds; C009495:titanium dioxide; C066075:vanadium pentoxide; D014025:Titanium; D007501:Iron; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase