Vestibulo-ocular dysfunction induced by cortical damage in man: a case report.
We studied the rare case of a patient presenting with vestibulo-ocular dysfunction and clinical vestibular symptoms after right temporo-parietal cortex infarction. The vestibulo-ocular reflex (VOR) was elicited in the dark, by sinusoidal (0.02; 0.05 and 0.1 Hz) and by step velocity rotation (100 degrees/s2) in clockwise and counterclockwise directions. Horizontal and vertical eye movements were recorded by DC electro-oculography (EOG). When compared to a control group of 8 healthy subjects, this patient presented VOR asymmetry with (1) a significant VOR velocity bias toward the lesioned side revealed as a vestibulo-ocular offset that occurred only under dynamic conditions (2) a significant reduction of the VOR time constant when rotation was directed to the lesioned side. VOR gain was normal. We suggest that the parieto-temporal cortex is implicated in the regulation of vestibulo-ocular symmetry in man. This cortical processing of vestibular integration might involve a multidimensional velocity storage integrator that subserves the maintenance of spatial coordinates along the spatial vertical axis.
Ventre-Dominey
J
J
INSERM Unité 94, Laboratoire Vision et Motricité, Bron, France. ventre-dominey@lyon151.inserm.fr
Vighetto
A
A
Denise
P
P
D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000503:physiopathology; D005133:Eye Movements / Q000502:physiology; D018466:Gravity Sensing / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology*; D009434:Neural Pathways / Q000503:physiopathology; D009949:Orientation / Q000502:physiology*; D010296:Parietal Lobe / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D010468:Perceptual Disorders / Q000473:pathology / Q000503:physiopathology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D012399:Rotation; D012678:Sensation Disorders / Q000473:pathology / Q000503:physiopathology; D013028:Space Perception / Q000502:physiology; D013702:Temporal Lobe / Q000293:injuries / Q000473:pathology / Q000502:physiology; D013998:Time Perception / Q000502:physiology