title: Mortality among male licensed pesticide users and their wives.
abstract: BACKGROUND
  We evaluated the mortality pattern of male licensed pesticide users and their wives in central Italy.
  
  
  METHODS
  The cohort consisted of 2978 male farmers licensed for buying and handling toxic pesticides during the period 1971-1973 and 2586 farmers' wives. The Standardized Mortality Ratio (SMRs) and their 95% Confidence Intervals (95% CI) were computed on the basis of regional death rates.
  
  
  RESULTS
  We found a lower than expected overall and cancer mortality. Non-Hodgkin's lymphoma was increased among women (SMR = 2.29, 0.62-5.86) but not in male farmers (SMR = 0.90, 0.24-2.30), while both sexes were characterized by an increased risk of leukemia (men: SMR = 1.44, 0.69-2.64; women: SMR = 2.41, 1.04-4.76), mainly due to myeloid leukemia (men: SMR = 2.43, 0.98-5.00; women: SMR = 3.14, 1.02-7.33).
  
  
  CONCLUSIONS
  Men and women tend to share the same mortality profile. The statistically significant increase of leukemia with a threefold increased risk of the myeloid subtype only among women suggests that different pattern of exposure or biological differences between genders should be considered in evaluating health risks in agricultural settings.
authors.affiliation: Department of Epidemiology, Lazio Regional Health Authority, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Sperati
authors.forename: E
authors.initials: E
authors.lastname: Rapiti
authors.forename: L
authors.initials: L
authors.lastname: Settimi
authors.forename: A
authors.initials: A
authors.lastname: Quercia
authors.forename: B
authors.initials: B
authors.lastname: Terenzoni
authors.forename: F
authors.initials: F
authors.lastname: Forastiere
mesh_terms: D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced / Q000401:mortality*; D002423:Cause of Death; D015331:Cohort Studies; D016001:Confidence Intervals; D005192:Family Health; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D016017:Odds Ratio; D010575:Pesticides / Q000009:adverse effects*; D018454:Spouses / Q000706:statistics & numerical data*
chemical_list: D010575:Pesticides