Radionuclide studies of articular cartilage in the early diagnosis of arthritis in the rabbit.
The compound Se-75 bis[beta-(N,N,N-trimethylamino-)ethyl]selenide diiodide (Se-75 BISTAES) has been synthesized and its biodistribution in rabbits studied. A high uptake of radioactivity is found in the knee cartilage. Good scans of the knee are obtained by nuclear scintigraphy at 15 minutes after the injection of Se-75 BISTAES. The results of an equilibrium dialysis study show that Se-75 BISTAES binds to chondroitin sulfate and the binding is directly proportional to the chondroitin concentration. It appears that Se-75 BISTAES or its derivative should have potential as an articular imaging agent.
Yu
S W
SW
Department of Nuclear Medicine, Singapore General Hospital, Singapore.
Shaw
S M
SM
Van Sickle
D C
DC
D000818:Animals; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D002809:Chondroitin Sulfates / Q000378:metabolism; D007719:Knee Joint / Q000000981:diagnostic imaging; D010003:Osteoarthritis / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics
D012644:Selenium Radioisotopes; C055707:bis(N,N,N-trimethylamino)ethylselenide-Se iodide; D002809:Chondroitin Sulfates