title: Sexual behaviors in autism: problems of definition and management.
abstract: Surveys of sexual behavior in autism suggest a variety of behavioral expression. However, the course of sexual development in autism is unplotted, leaving questions about the normalcy of specific behaviors. Even less is known about deviations of sexual development and the incidence of paraphilias in this population. We explore the problems of definition of sexual behaviors and describe a case report that highlights the difficulties of management. An application of a testosterone-suppressing medication and its effect on sexual behavior are reported. After failure of behavioral and educational programs, leuprolide, an injectable antiandrogen, resulted in suppression of behaviors and retention of the participants' community placement. Follow-up for almost 3 years shows no abnormal physical effects. Dosage has been tapered over that period to a low but effective dose. Directions for research are discussed.
authors.affiliation: Division of Child and Adolescent Psychiatry, University of Minnesota, Minneapolis 55455, USA. Realm001@maroon.tc.umn.edu
authors.forename: G M
authors.initials: GM
authors.lastname: Realmuto
authors.forename: L A
authors.initials: LA
authors.lastname: Ruble
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D008297:Male; D008418:Masturbation / Q000517:prevention & control; D010262:Paraphilic Disorders / Q000150:complications* / Q000517:prevention & control*; D012725:Sexual Behavior / Q000187:drug effects*; D012920:Social Behavior Disorders / Q000209:etiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D016729:Leuprolide