[Action of neuropeptides on the status of neuronal populations in the post-resuscitation period: structural-functional correlation].
Effects of some neuropeptides and hormones (oxytocin, melanostatin, oxytocin in combination with estradiol, somatostatin) on neurons of the V cortical layer, Purkinje cells of medial and lateral regions of rat cerebellum were studied in rats after 15 minutes of cardiac arrest. A single administration of the peptides after successful cardiopulmonary resuscitation improved the condition of neuronal populations (prevented dystrophy and cell death), accelerated neurological recovery. One of the mechanisms of action of oxytocin, melanostatin and oxytocin in combination with estradiol is elevated number of satellite glial elements of the nervous tissue. Responses of varying neuronal populations to neuropeptide action are different. These data are essential for design of pathogenetic methods of prevention and treatment of posthypoxic encephalopathies.
Avrushchenko
M Sh
MSh
Volkov
A V
AV
D000818:Animals; D004353:Drug Evaluation, Preclinical; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D012151:Resuscitation; D013329:Structure-Activity Relationship
D009479:Neuropeptides
Deĭstvie neĭropeptidov na sostoianie neĭronal'nykh populiatsiĭ v postreanimatsionnom periode: strukturno-funktsional'nye korreliatsii.