title: Gas chromatographic analysis of fosfomycin in plasma for pharmacokinetic analysis.
abstract: An efficient method for gas chromatographic analysis of fosfomycin in plasma was developed for preliminary investigations of the bioavailability in poultry of 3 commercial complexes of fosfomycin: a levorotatory Ca(-) salt, a racemic Ca(+/-) salt, and a tromethamine (THAM) salt. The method was used to determine whether the less expensive racemic mixture would provide equivalent levels of fosfomycin in blood as the pure Ca(-) form and the THAM salt. The THAM salt, a more expensive product to market, was thought to have the greatest bioavailability. The assay is selective, sensitive, and applicable to pharmacokinetic analysis.
authors.affiliation: Chemsultants, Ltd., Ozona, FL 34660, USA.
authors.forename: G K
authors.initials: GK
authors.lastname: Webster
authors.forename: R G
authors.initials: RG
authors.lastname: Bell
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000493:pharmacokinetics*; D001682:Biological Availability; D002118:Calcium; D002645:Chickens / Q000097:blood; D002849:Chromatography, Gas / Q000379:methods*; D005578:Fosfomycin / Q000097:blood* / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D013810:Therapeutic Equivalency; D014325:Tromethamine
chemical_list: D000900:Anti-Bacterial Agents; D014325:Tromethamine; D005578:Fosfomycin; D002118:Calcium