Bioassays for itraconazole blood levels: an interlaboratory collaborative study.
Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy-itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently to indicate the relative level of antifungal activity in the test samples.
Odds
F C
FC
Janssen Research Foundation, Beerse, Belgium.
Dupont
B
B
Rinaldi
M G
MG
Stevens
D A
DA
Warnock
D W
DW
Woestenborghs
R
R
D000935:Antifungal Agents / Q000097:blood*; D001681:Biological Assay / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D017964:Itraconazole / Q000031:analogs & derivatives / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole