A novel HLA-DR12 allele (DRB1*1206) found in a Korean B-cell line.
At least 6 HLA-DRB1*12 alleles have been identified to date with nucleotide polymorphism occurring at codons 37, 57-58, 60, 67, 85 and 87. In this report, we describe the identification of another new HLA-DRB1*12 allele: DRB1*1206. This novel allele was found in an Epstein-Barr virus (EBV)-transformed Korean B-cell line "K-KT" having the HLA-phenotype A3, 24; B44, 61; Cw3; Bw4, 6; DR12, 13 during full-length cDNA isolation for cell line characterization and for production of HLA-DR recombinant proteins. The allele was identified initially by cycle sequencing of subcloned HLA-DRB full-length cDNA.
Maeng
C Y
CY
Peptide Engineering Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
Kim
K H
KH
Kang
J H
JH
Han
H
H
Kim
K L
KL
D000483:Alleles; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D001483:Base Sequence; D002460:Cell Line; D018076:DNA, Complementary; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
D018076:DNA, Complementary; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains