[Survival of patients with AIDS treated with protease inhibitors].
OBJECTIVE
Make a volarization of the effect on survival of the protease inhibitors used on patients with established-AIDS.


METHODS
Retrospective study on patients diagnosed of AIDS between January 1989 and March 1998. The main objective is the time between diagnosis and dead. It is compared the survival curve of the patients on treatment with protease inhibitors (PI) with the ones without them. We use the methods of Kaplan-Meier and log-rank.


RESULTS
We analyzed 99 patients diagnosed of AIDS. Fifteen were treated with PI in combination and eighty-four with regimens without them. The number of CD4 and the age at the beginning of the study, the type of transmission and the gender were similar at the two groups. The median survival of the treated with PI was 47 (4 months (CI 95%: 39-55), and the one of the no treated as 26(3 months (CI 95%: 20-32) (p = 0.0027)


CONCLUSIONS
The treatment with Protease inhibitors plus other antiviral medications is associated with a survival prolongation in patients with AIDS.
Martínez Avilés
P
P
Servicio de Medicina Interna, Hospital General Marina Alta, Denia, Alicante.
Berbegal Serra
J
J
López Benito
I
I
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000401:mortality; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors
Supervivencia de pacientes con SIDA tratados con inhibidores de la proteasa.