Molecular evidence of mother-to-infant transmission of hepatitis G virus among women without known risk factors for parenteral infections.
Hepatitis G virus (HGV) RNA was detected in 18 of 133 pregnant women from Tanzania without known risk factors for HGV infection and in 7 of 18 children born to HGV RNA-positive mothers. Molecular evidence of mother-to-infant transmission was obtained only for three of seven children. HGV RNA was also detected in 4 of 42 children born to non-HGV-infected women. Thus, mechanisms other than materno-filial may play an important role in HGV transmission during early childhood.
Menéndez
C
C
Liver Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain.
Sánchez-Tapias
J M
JM
Alonso
P L
PL
Giménez-Barcons
M
M
Kahigwa
E
E
Aponte
J J
JJ
Mshinda
H
H
Navia
M M
MM
Jiménez de Anta
M T
MT
Rodés
J
J
Saiz
J C
JC
D005260:Female; D018067:Flaviviridae / Q000235:genetics / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008969:Molecular Sequence Data; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D020365:RNA Helicases; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012307:Risk Factors; D012697:Serine Endopeptidases; D013636:Tanzania; D017361:Viral Nonstructural Proteins / Q000235:genetics; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D020365:RNA Helicases; D012367:RNA, Viral; D012697:Serine Endopeptidases; D017361:Viral Nonstructural Proteins; C060028:NS3 protein, flavivirus; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases