Thalamic metabolic rate predicts EEG alpha power in healthy control subjects but not in depressed patients.
BACKGROUND
EEG alpha power has been demonstrated to be inversely related to mental activity and has subsequently been used as an indirect measure of brain activation. The hypothesis that the thalamus serves as a neuronal oscillator of alpha rhythms has been supported by studies in animals, but only minimally by studies in humans.


METHODS
In the current study, PET-derived measures of regional glucose metabolism, EEG, and structural MRI were obtained from each participant to assess the relation between thalamic metabolic activity and alpha power in depressed patients and healthy controls. The thalamus was identified and drawn on each subject's MRI. The MRI was then co-registered to the corresponding PET scan and metabolic activity from the thalamus extracted. Thalamic activity was then correlated with a 30-min aggregated average of alpha EEG power.


RESULTS
Robust inverse correlations were observed in the control data, indicating that greater thalamic metabolism is correlated with decreased alpha power. No relation was found in the depressed patient data.


CONCLUSIONS
The results are discussed in the context of a possible abnormality in thalamocortical circuitry associated with depression.
Lindgren
K A
KA
Department of Psychology, University of Wisconsin, Madison 53706, USA.
Larson
C L
CL
Schaefer
S M
SM
Abercrombie
H C
HC
Ward
R T
RT
Oakes
T R
TR
Holden
J E
JE
Perlman
S B
SB
Benca
R M
RM
Davidson
R J
RJ
D000328:Adult; D000513:Alpha Rhythm; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000378:metabolism* / Q000523:psychology; D004585:Electrooculography; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D006304:Health Status; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology; D019275:Radiopharmaceuticals; D012720:Severity of Illness Index; D013788:Thalamus / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose