title: Variation and evolution of the citric-acid cycle: a genomic perspective.
abstract: The presence of genes encoding enzymes involved in the citric-acid cycle has been studied in 19 completely sequenced genomes. In the majority of species, the cycle appears to be incomplete or absent. Several distinct, incomplete cycles reflect adaptations to different environments. Their distribution over the phylogenetic tree hints at precursors in the evolution of the citric-acid cycle.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. huynen@embl-heidelberg.de
authors.forename: M A
authors.initials: MA
authors.lastname: Huynen
authors.forename: T
authors.initials: T
authors.lastname: Dandekar
authors.forename: P
authors.initials: P
authors.lastname: Bork
mesh_terms: D001105:Archaea / Q000235:genetics / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D002952:Citric Acid Cycle / Q000235:genetics*; D019143:Evolution, Molecular; D014644:Genetic Variation; D015003:Yeasts / Q000235:genetics / Q000378:metabolism