title: [Comparison of changes in oncogene of human embryo lung cells before and after chemical modification for chrysotile].
abstract: OBJECTIVE
  To seek for a suitable chamical agent for surface modification of chrysotile.
  
  
  METHODS
  The effects of aluminum citrate, mixed rare earth and sodium selenite on c-Ha-ras oncogene and P21ras protein in the transformation of human embryo lung cells caused by chrysotile were studied.
  
  
  RESULTS
  The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile were significantly higher than those in the controls. The transcription level of c-Ha-ras oncogene and the content of P21ras in those exposed to chrysotile treated in advance with three kinds of chemicals mentioned above were significantly lower than those in untreated.
  
  
  CONCLUSIONS
  Treatment of chrysotile with three kinds of above-mentioned chemicals in advance could reduce its carcinogenecity in human beings.
authors.affiliation: National Institute of Occupational Safety and Health, Beijing.
authors.forename: J
authors.initials: J
authors.lastname: Fan
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Liu
mesh_terms: D017607:Aluminum Compounds; D017632:Asbestos, Serpentine / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002478:Cells, Cultured; D004347:Drug Interactions; D004622:Embryo, Mammalian; D011905:Genes, ras; D006801:Humans; D008168:Lung / Q000166:cytology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism*; D018038:Sodium Selenite
chemical_list: D017607:Aluminum Compounds; D017632:Asbestos, Serpentine; D002273:Carcinogens; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D018038:Sodium Selenite