title: Nuclear transport and transcriptional regulation.
abstract: Studies over the past 10 years have provided major insights into the molecular mechanisms responsible for active transport of macromolecules in and out of the nucleus. Nucleocytoplasmic transport pathways correspond to active and signal-mediated processes that involve substrates, adaptors and receptors. Regulation of both nuclear import and nuclear export is mainly exerted at the level of transport complex formation and has emerged as one of the most efficient mechanisms to adapt gene expression to the cell environment by restricting the access of transcriptional regulators to their target genes.
authors.affiliation: Laboratoire de Transport nucléocytoplasmique, Institut Curie-CNRS UMR144, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Turpin
authors.forename: B
authors.initials: B
authors.lastname: Ossareh-Nazari
authors.forename: C
authors.initials: C
authors.lastname: Dargemont
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D009685:Nuclear Envelope / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology*