title: Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.
abstract: The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.
authors.affiliation: Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: E C
authors.initials: EC
authors.lastname: Torres-Santos
authors.forename: J M
authors.initials: JM
authors.lastname: Rodrigues
authors.forename: D L
authors.initials: DL
authors.lastname: Moreira
authors.forename: M A
authors.initials: MA
authors.lastname: Kaplan
authors.forename: B
authors.initials: B
authors.lastname: Rossi-Bergmann
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D047188:Chalcones; D016503:Drug Delivery Systems; D005260:Female; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D011091:Polyesters / Q000008:administration & dosage*
chemical_list: C118962:2',6'-dihydroxy-4'-methoxychalcone; D000977:Antiparasitic Agents; D047188:Chalcones; D011091:Polyesters; C033616:poly(lactide); D002599:Chalcone