Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent.
Cycloprodigiosin hydrochloride (cPrG*HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG*HCl was also observed in vivo. These results indicate that cPrG*HCl is a potent antimalarial drug.
Kim
H S
HS
Department of Pharmaceutical Information Science, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Hayashi
M
M
Shibata
Y
Y
Wataya
Y
Y
Mitamura
T
T
Horii
T
T
Kawauchi
K
K
Hirata
H
H
Tsuboi
S
S
Moriyama
Y
Y
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006088:Gram-Negative Aerobic Bacteria / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000302:isolation & purification / Q000494:pharmacology*; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010963:Plasmodium falciparum / Q000187:drug effects*; D011758:Pyrroles / Q000302:isolation & purification / Q000494:pharmacology*
D000962:Antimalarials; D007211:Indoles; D011758:Pyrroles; C108328:cycloprodigiosin