title: A randomized trial of the effect of midazolam on intraocular pressure.
abstract: OBJECTIVE
  The effect of midazolam on intraocular pressure (IOP) in adults was studied as an initial step in determining whether it can be used as a preoperative anxiolytic or sedative agent in children with glaucoma who are undergoing examination for IOP measurements.
  
  
  METHODS
  This study followed a prospective, placebo controlled, randomized, double masked design. Fifty-five participants were enrolled after informed consent was obtained. Each enrolled patient underwent a brief history and eye examination. Measurements of IOP were taken at baseline and 5, 10, and 15 minutes after intravenous administration of 1 mg midazolam or placebo. IOP was the primary outcome measured.
  
  
  RESULTS
  There was no difference in IOP fluctuation from baseline between patients who received midazolam and those who received placebo.
  
  
  CONCLUSIONS
  Early results indicate that because midazolam does not lower IOP, it may be a useful adjunct to ketamine anesthesia in children with glaucoma undergoing ophthalmologic examination under anesthesia. However, studies of midazolam must be conducted in children and patients with glaucoma before its use in these populations can be recommended.
authors.affiliation: Department of Ophthalmology, University of Florida, Gainesville, USA.
authors.forename: K
authors.initials: K
authors.lastname: Carter
authors.forename: L K
authors.initials: LK
authors.lastname: Faberowski
authors.forename: M B
authors.initials: MB
authors.lastname: Sherwood
authors.forename: L S
authors.initials: LS
authors.lastname: Berman
authors.forename: S
authors.initials: S
authors.lastname: McGorray
mesh_terms: D000771:Anesthesia, Intravenous / Q000379:methods; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D011446:Prospective Studies; D014065:Tonometry, Ocular
chemical_list: D018686:Anesthetics, Intravenous; D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D008874:Midazolam