Antioxidant activity of michellamine alkaloids.
The alkaloids michellamines A, B, and C are natural products isolated from a Central African tropical plant Ancistrocladus korupensis. We have investigated the radical scavenging ability of these compounds. The alkaloids inhibited the azo-induced oxidation of beta-phycoerythrin with IC50 values in the 0.5- to 0.8-microM range. Michellamine B also protected rat liver mitochondria against lipid peroxidation induced by adenosine diphosphate and Fe2+. The alkaloids were more potent antioxidants in these assays than several compounds being considered clinically as chemoprevention agents.
White
E L
EL
Biochemistry Department, Southern Research Institute, Birmingham, AL 35205, USA. white@sri.org
Ross
L J
LJ
Hobbs
P D
PD
Upender
V
V
Dawson
M I
MI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D000975:Antioxidants; D007546:Isoquinolines; D009281:Naphthalenes; C072235:michellamine A