title: Functional outcome in amputation versus limb sparing of patients with lower extremity sarcoma: a matched case-control study.
abstract: OBJECTIVE
  To quantify the differences in physical disability and handicap experienced by patients with lower extremity sarcoma who required amputation for their primary tumor as compared with those treated by limb-sparing surgery.
  
  
  METHODS
  Matched case-control study. Twelve patients with amputation were matched with 24 patients treated by limb-sparing surgery on the following variables: age, gender, length of follow-up, bone versus soft-tissue tumor, anatomic site, and treatment with adjuvant chemotherapy.
  
  
  METHODS
  Patients who underwent above-knee amputation (AKA) or below-knee amputation (BKA) for primary soft-tissue or bone sarcoma, who had not developed local or systemic recurrence, and who had been followed up for at least 1 year since surgery.
  
  
  METHODS
  The Toronto Extremity Salvage Score (TESS), a measure of physical disability; the Shortform-36 (SF-36), a generic health status measure; and the Reintegration to Normal Living (RNL), a measure of handicap.
  
  
  RESULTS
  Mean TESS score for the patients with amputations was 74.5 versus 85.1 for the limb-sparing patients. (p = .15). Only the physical function subscale of the SF-36 showed statistically significant differences, with means of 45 and 71.1 for the amputation versus limb-sparing groups, respectively (p = .03). The RNL for the amputation group was 84.4 versus 97 for the limb-sparing group (p = .05). Seven of the 12 patients with amputations experienced ongoing difficulty with the soft tissues overlying their stumps.
  
  
  CONCLUSIONS
  There was a trend toward increased disability for those in the amputation group versus those in the limb-sparing group, with the amputation group showing significantly higher levels of handicap. These data suggest that the differences in disability between amputation and limb-sparing patients are smaller than anticipated. The differences may be more notable in measuring handicap.
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital and University of Toronto, Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Devlin
authors.forename: A M
authors.initials: AM
authors.lastname: Griffin
authors.forename: J S
authors.initials: JS
authors.lastname: Wunder
authors.forename: R S
authors.initials: RS
authors.lastname: Bell
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000534:rehabilitation / Q000601:surgery*; D016022:Case-Control Studies; D006233:Persons with Disabilities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000601:surgery*; D008297:Male; D008722:Methods; D012516:Osteosarcoma / Q000601:surgery; D012509:Sarcoma / Q000534:rehabilitation / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000534:rehabilitation / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome