title: Differential immune system changes with acute and persistent stress for optimists vs pessimists.
abstract: This study investigated whether acute and persistent stressors and life change events were followed by changes in immune status, and whether dispositional optimism moderated these relationships. Thirty-nine healthy women ages 18-45 were followed prospectively for 3 months, with weekly assessment of acute and persistent stressors and monthly assessment of life events and immune parameters (NK cell cytotoxicity, and CD4 and CD8 T cell subsets). The study used an autoregressive linear model to examine how weekly appraised acute and persistent stress levels were associated with immune parameters in the subsequent week. Analyses revealed that the immune outcomes were differentially affected by acute and persistent stressors. Further, the association between acute stress and subsequent immune parameters was buffered by an optimistic perspective. However, when stress persisted at high levels, optimists showed more subsequent immune decrements than pessimists.
authors.affiliation: Department of Psychiatry, University of California, San Francisco, USA.
authors.forename: F
authors.initials: F
authors.lastname: Cohen
authors.forename: K A
authors.initials: KA
authors.lastname: Kearney
authors.forename: L S
authors.initials: LS
authors.lastname: Zegans
authors.forename: M E
authors.initials: ME
authors.lastname: Kemeny
authors.forename: J M
authors.initials: JM
authors.lastname: Neuhaus
authors.forename: D P
authors.initials: DP
authors.lastname: Stites
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D008016:Life Change Events; D016014:Linear Models; D018655:Lymphocyte Count; D008875:Middle Aged; D010551:Personality / Q000502:physiology*; D010556:Personality Tests; D011446:Prospective Studies; D013315:Stress, Psychological / Q000276:immunology* / Q000523:psychology*