title: Surgical treatment of left ventricular post-infarction aneurysm with endoventriculoplasty: late clinical and functional results.
abstract: OBJECTIVE
  The temporal response to endoventriculoplasty (EVP) has not been well defined. We have evaluated the long-term clinical and functional results of this technique.
  
  
  METHODS
  From 1988 to 1997, 121 patients underwent aneurysmectomy by EVP associated with myocardial revascularization for anteroapical left ventricular postinfarction aneurysm. Among these, 39 patients (43%) underwent early post-operative cardiac catheterization (within 3 months maximum), and were available to be revaluated after a mean follow-up time of 56+/-28 months, by means of a new hemodynamic study. Left ventricular silhouettes were analyzed by means of a special software.
  
  
  RESULTS
  The mean New York Heart Association functional class decreased from 2.5+/-0.9 to 1.6+/-0.8 (P<0.001) late postoperatively. The global ejection fraction improved early postoperatively from 43+/-13 to 61+/-13% (P<0.001), and late postoperatively slightly decreased to 42+/-13% (ns) versus preoperative values. Left ventricular end diastolic pressure early postoperatively fell from 16.8+/-7 to 15.7+/-6.7 (ns), and late postoperatively increased to 21.6+/-8.8 (ns) versus preoperative values. Pulmonary artery pressure rose early postoperatively from 31.5+/-6.4 to 32.1+/-6.7 (ns), and late postoperatively to 34.9+/-8.9 (ns). The global contractility score decreased early postoperatively from 42.3+/-9.6 to 28.4+/-13.6 (P<0.001); the global late postoperative contractily was 35+/-14 (ns) versus preoperative values. Patients who benefit most from the operation were those with a normal postoperative contraction pattern, where ejection fraction improved respectively early postoperatively from 43+/-13 to 63+/-11% (P<0.001), and late postoperatively to 49+/-10% (P<0.001) versus preoperative values. Occlusion or critical stenosis of bypass grafts occurred in 10 patients (25.6%). There were no significant differences in hemodynamic data and hypokinesis score changes between patients with patent or occluded bypass graft, and between patients with mono or multivessel disease. The operative mortality was 6.3%, and 8.8% needed intraaortic balloon counterpulsation. The actuarial survival rates at 5 and 7 years were 73+/-6 and 61+/-6%. The mean follow-up period was 68 months (with 112 months maximum).
  
  
  CONCLUSIONS
  We conclude that, in our patients group, EVP of left ventricular aneurysm associated with coronary grafting improves clinical status after operation. We registered a trend for a mild hemodynamic worsening, irrespective of coronary artery disease except in those patients who had shown a normal postoperative contraction pattern.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Luigi Sacco Hospital, Milan, Italy.
authors.forename: D G
authors.initials: DG
authors.lastname: Di Mattia
authors.forename: P
authors.initials: P
authors.lastname: Di Biasi
authors.forename: M
authors.initials: M
authors.lastname: Salati
authors.forename: A
authors.initials: A
authors.lastname: Mangini
authors.forename: P
authors.initials: P
authors.lastname: Fundarò
authors.forename: C
authors.initials: C
authors.lastname: Santoli
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D017023:Coronary Angiography; D005260:Female; D006322:Heart Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006352:Heart Ventricles / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D009204:Myocardial Revascularization; D016896:Treatment Outcome; D014463:Ultrasonography