title: Plasma baclofen levels in children receiving continuous intrathecal baclofen infusion.
abstract: To determine the plasma baclofen concentrations of children undergoing continuous intrathecal baclofen infusion for treatment of cerebral spasticity, we assayed plasma samples from six children, 8 to 18 years of age, who were receiving intrathecal baclofen at constant rates of 77 to 400 micrograms/day. Plasma levels were at or below the limit of quantification (10 ng/mL) in all patients.
authors.affiliation: Department of Neurosurgery, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA. Leland_Albright@poplar.chp.edu
authors.forename: A L
authors.initials: AL
authors.lastname: Albright
authors.forename: B L
authors.initials: BL
authors.lastname: Shultz
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001418:Baclofen / Q000008:administration & dosage* / Q000097:blood*; D002547:Cerebral Palsy / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D010949:Plasma / Q000737:chemistry
chemical_list: D001418:Baclofen