Preparation, stability studies and pharmacological behavior of [186Re]Re-HEDP.
99mTc-HEDP is widely used as a bone imaging agent and its Re analog [186Re]Re-HEDP is now well established as a therapeutic radiopharmaceutical for palliation of pain due to bone metastases. In the present paper, we report the work carried out for the preparation of stable 186Re-HEDP which retains RC purity up to 5 days when stored at 4 degrees C. 186Re was prepared by irradiation of natural Re metal at a flux of 3 x 10(13) neutrons/cm2/s for seven days and processed after a cooling period of four days. The specific activity of 186Re formed was approximately 35 mCi/mg. A complex with RC purity > 98% could be prepared by varying the reaction conditions. By carefully optimizing the reaction and storage conditions, a complex which was stable for over 4 days could be synthesized. Bio-distribution studies carried out in rats revealed approximately 30% bone uptake of 186Re-HEDP at 3 h postinjection which remained almost constant for 48 h, at which time there was negligible activity in other organs.
Kothari
K
K
Isotope Division, Bhabha Atomic Research Centre, Mumbai, India.
Pillai
M R
MR
Unni
P R
PR
Shimpi
H H
HH
Noronha
O P
OP
Samuel
A M
AM
D000818:Animals; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D012968:Etidronic Acid / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D009942:Organometallic Compounds; D011868:Radioisotopes / Q000737:chemistry* / Q000494:pharmacology; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000737:chemistry* / Q000494:pharmacology*; D014018:Tissue Distribution
D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C101598:rhenium-186 HEDP; D012211:Rhenium; D012968:Etidronic Acid