How can one explain aneuploidy status in fibromatous and lipomatous naevus cell naevus?
34 lightly fibromatous, 23 heavily fibromatous, 5 lipomatous and 10 naevus cell naevi were stained with Feulgen kit in order to evaluate their ploidy status with CAS 200 image analyzer. 26/34 lightly fibromatous, 18/23 heavily fibromatous, and 5/5 lipomatous naevi were either suspicious for aneuploidy (Auer III) or clearly aneuploid (Auer IV). In contrast all 10/10 naevus cell naevi were euploid. Proliferation (S-phase) was not increased in naevi fibromatously and lipomatously changed. The mechanisms leading to aneuploidy are discussed.
Korabiowska
M
M
Department of Cytopathology, Georg August University Göttingen, Germany.
Brinck
U
U
Ruschenburg
I
I
Kellner
S
S
Droese
M
M
Berger
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009506:Nevus / Q000235:genetics* / Q000473:pathology