title: Persistent osteopenia in adolescent idiopathic scoliosis. A longitudinal follow up study.
abstract: METHODS
  A follow-up study assessing the bone mineral dynamics in adolescent patients with idiopathic scoliosis and associated osteopenia.
  
  
  OBJECTIVE
  To investigate whether osteopenia in patients with adolescent idiopathic scoliosis is a transient phenomenon or a persistent problem.
  
  
  BACKGROUND
  Investigators have suggested a significant correlation of osteopenia with adolescent idiopathic scoliosis. Because one half of the skeletal mass is acquired during the adolescent years, it is of importance to know whether the osteopenia is transient or persistent.
  
  
  METHODS
  Using dual-energy x-ray absorptiometry, bone mineral density of bilateral proximal femurs was studied longitudinally in 70 healthy control subjects and 14 patients with adolescent idiopathic scoliosis with significant osteopenia more than 2 standard deviations below the mean normal value.
  
  
  RESULTS
  The 14 girls with osteopenic adolescent idiopathic scoliosis who were followed up longitudinally for up to 3 years showed persistent and significantly lower bone mineral density when compared with normal age-, sex- and maturity-matched control subjects.
  
  
  CONCLUSIONS
  Patients with adolescent idiopathic scoliosis are at increased risk of osteoporosis than are healthy adolescents. The lower rate of increase of bone mineral density in patients with adolescent idiopathic scoliosis who have low bone mineral density could predict a significantly lower peak bone mass in adulthood, with all the associated problems of osteoporosis. Further investigation is needed to define whether osteopenia-associated scoliosis has the same cause, pathogenetic mechanism, and risk of progression when compared with adolescent scoliosis without osteopenia.
authors.affiliation: Department of Orthopedics and Traumatology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. jackcheng@cuhk.edu.hk
authors.forename: J C
authors.initials: JC
authors.lastname: Cheng
authors.forename: X
authors.initials: X
authors.lastname: Guo
authors.forename: A H
authors.initials: AH
authors.lastname: Sher
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D001837:Body Weights and Measures; D015519:Bone Density / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D005260:Female; D005269:Femur / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D012600:Scoliosis / Q000150:complications* / Q000503:physiopathology