[Immunological rejection in rat embryonic brain tissue transplantation: experimental study].
The embryonic cerebral neocortex from rat or mouse donors which were 16 to 18-day-old embryos was grafted into the neocortex of adult recipient rats. One group was treated with cyclosporin A. At different time after transplantation, the brain graft tissues were stained immunocytochemically to exmine the expression of MHC-class II antigens and both subsets of T-cells, helper-inducer and cytotoxic-suppressor T-cells. The results indicated that the survival rate of treated group was higher than that of non treated with immunosuppressant. Immunocytochemical evaluation showed that a large number of helper T-cells and cytotoxic T-cells appeared, with a significant increase of the number of class II major histocompatibility complex (MHC) expressing cells within and around the allografts was observed. These MHC-class II antigen-positive cells may be lymphocytes, microglia and astrocytes. We conclude that the CNS is not a "immunologically privileged site" and there is graft rejection in brain transplantation. It is necessary for brain transplantation to be treated with immunosuppressant.
Liu
J
J
Department of Neurosurgery, Xinqiao Hospital, 3rd Military Medical College, Chongqing.
Zhang
K
K
D000818:Animals; D016380:Brain Tissue Transplantation; D002540:Cerebral Cortex / Q000196:embryology / Q000637:transplantation*; D016572:Cyclosporine / Q000494:pharmacology; D005260:Female; D016332:Fetal Tissue Transplantation; D006084:Graft Rejection; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
D007166:Immunosuppressive Agents; D016572:Cyclosporine