title: Prepartum mixed type cavernous-capillary hemangioma arising in nevus flammeus.
abstract: OBJECTIVE
  Capillary hemangioma may appear de novo and involute during the first decade of life, but rarely during pregnancy. This study describes the clinical and histologic findings of an eyelid mixed type cavernous-capillary hemangioma arising in a nevus flammeus and discusses the differential diagnosis of this lesion.
  
  
  METHODS
  Clinicopathologic case report.
  
  
  METHODS
  A reddish, protruding eyelid mass arising from a nevus flammeus at the eyelid margin in a 26-year-old woman was monitored during her pregnancy. Postpartum, the mass was excised and examined histologically.
  
  
  RESULTS
  The lobulated tumor recurred during the second pregnancy and partially regressed following delivery. It was composed of mixed elements of cavernous and capillary hemangioma that superficially resembled Kaposi sarcoma, set against the background of a nevus flammeus.
  
  
  CONCLUSIONS
  The differential diagnosis of discrete prepartum vascular tumor arising in nevus flammeus includes mixed capillary-cavernous hemangioma, pseudo-Kaposi sarcoma, granuloma gravidarum, and angiodermatitis. A common stimulus during pregnancy may be the inciting factor for the development of these tumors.
authors.affiliation: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston 02114, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rumelt
authors.forename: T T
authors.initials: TT
authors.lastname: You
authors.forename: H D
authors.initials: HD
authors.lastname: Remulla
authors.forename: P A
authors.initials: PA
authors.lastname: Rubin
authors.forename: F A
authors.initials: FA
authors.lastname: Jakobiec
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000473:pathology*; D005260:Female; D018324:Hemangioma, Capillary / Q000473:pathology*; D006392:Hemangioma, Cavernous / Q000473:pathology*; D006801:Humans; D018198:Mixed Tumor, Malignant / Q000473:pathology*; D019339:Port-Wine Stain / Q000473:pathology*; D011247:Pregnancy; D012008:Recurrence