title: Kidney transplantation in a child with posterior urethral valve from a hepatitis B virus-carrier mother. Report of a case with special reference to urinary tract reconstruction for dysfunctionalized uropathies and seroimmunological preparation against viral transmission.
abstract: The case of a 7-year-old boy with posterior urethral valve (PUV) who underwent successful kidney transplantation for progressive renal failure is reported. He required complex reconstructive surgery for PUV-related disorders, and also specific serological preparation for hepatitis B (HB) as his living donor mother was a proven carrier. By carefully executing the principles of reconstructive surgery and with well-planned seroimmunological preparation, we have demonstrated that successful kidney transplantation can be done from an HB Ag-positive mother to an HB Ag- and HB Ab-negative son, even when his urinary tract is severely dysfunctional due to PUV.
authors.affiliation: Department of Urology, Hokkaido University School of Medicine, Sapporo, and Asahikawa Municipal Hospital, Asahikawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Seki
authors.forename: T
authors.initials: T
authors.lastname: Koyanagi
authors.forename: K
authors.initials: K
authors.lastname: Nonomura
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Chikaraishi
authors.forename: K
authors.initials: K
authors.lastname: Kanagawa
mesh_terms: D002353:Carrier State; D002648:Child; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000517:prevention & control / Q000635:transmission*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D011300:Preoperative Care; D051437:Renal Insufficiency / Q000209:etiology / Q000601:surgery*; D014019:Tissue Donors; D016896:Treatment Outcome; D014521:Urethra / Q000002:abnormalities* / Q000601:surgery; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000601:surgery
chemical_list: D017325:Hepatitis B Vaccines