Hammondia hammondi organelle proteins are recognized by monoclonal antibodies directed against organelles of Toxoplasma gondii.
Hammondia hammondi and Toxoplasma gondii, 2 closely related coccidia of cats, are known to share many antigenic molecules as shown by serologic cross reactivity. Monoclonal antibodies (MAbs) directed against the internal organelles of Toxoplasma gondii were tested by immunofluorescence assay and immunoelectron microscopy on the tachyzoites of H. hammondi. The MAbs anti-apex, anti-dense granules, anti-micronemes, and anti-rhoptries recognized, although weakly, the corresponding antigens on H. hammondi. This finding demonstrates that organelles of the 2 parasites are not only morphologically, but also antigenically, similar.
Riahi
H
H
Service de Parasitologie-Mycologie, CHU Dupuytren, Limoges, France.
Leboutet
M J
MJ
Bouteille
B
B
Dubremetz
J F
JF
Dardé
M L
ML
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000953:Antigens, Protozoan / Q000276:immunology; D002371:Cat Diseases / Q000469:parasitology; D002415:Cats; D003048:Coccidiosis / Q000469:parasitology / Q000662:veterinary; D021741:Eimeriida / Q000145:classification / Q000276:immunology* / Q000648:ultrastructure; D007150:Immunohistochemistry; D051379:Mice; D016253:Microscopy, Immunoelectron; D015388:Organelles / Q000276:immunology; D015800:Protozoan Proteins / Q000276:immunology*; D014122:Toxoplasma / Q000145:classification / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D015800:Protozoan Proteins