title: Resolved splenic accumulation of Tc-99m HMDP after recovery of disseminated intravascular coagulation in a patient with rhabdomyosarcoma.
abstract: Unusual, intense splenic radioactivity was seen on bone scintigraphy with Tc-99m HMDP in a 14-year-old boy with alveolar rhabdomyosarcoma complicated by disseminated intravascular coagulation. Abnormal splenic radioactivity was resolved after recovery from the disseminated intravascular coagulation. During treatment of disseminated intravascular coagulation and tumors, the patient received repeated blood transfusions, resulting in iron overload, but this did not prevent the abnormal splenic uptake from resolving. This case indicates that disseminated intravascular coagulation may be a cause of splenic accumulation of bone-seeking agents, and that abnormal splenic uptake can be resolved.
authors.affiliation: Department of Radiology, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suga
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: N
authors.initials: N
authors.lastname: Kume
mesh_terms: D000293:Adolescent; D004211:Disseminated Intravascular Coagulation / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000378:metabolism*; D018232:Rhabdomyosarcoma, Alveolar / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy; D013154:Spleen / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate