title: Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic.
authors.affiliation: Division of Cardiovascular and Pulmonary Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania, 19406, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Torphy
authors.forename: M S
authors.initials: MS
authors.lastname: Barnette
authors.forename: D C
authors.initials: DC
authors.lastname: Underwood
authors.forename: D E
authors.initials: DE
authors.lastname: Griswold
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
authors.forename: R D
authors.initials: RD
authors.lastname: Murdoch
authors.forename: R B
authors.initials: RB
authors.lastname: Nieman
authors.forename: C H
authors.initials: CH
authors.lastname: Compton
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D009570:Nitriles; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D009570:Nitriles; D010726:Phosphodiesterase Inhibitors; C433247:Cilomilast