[Interleukin-1 and nitric oxide involved in the pathogenesis of diabetes)].
Insulin-dependent diabetes mellitus (IDDM) is not only a common metabolic disorder in industrialised countries, but its incidence is still increasing, especially in Scandinavia. The article consists in a review of evidence implicating nitric oxide (NO) and the cytokine, interleukin-1 (IL-1), in the pathogenesis of IDDM. Cytotoxic effects of IL-1 and NO, generated through autoimmune reactions associated with insulitis and impairing the function of insulin-producing pancreatic beta-cells in IDDM, are discussed, as are possible pharmacological strategies for blocking this toxicity. Compounds capable of blocking IL-1 cell surface receptors and NO synthesis may prove beneficial in protecting beta-cells from autoimmune assault in IDDM. If IL-1 causes beta-cell dysfunction and destruction through NO synthesis in IDDM, several pathways in the IL-1-NO system are attractive potential targets for drugs protecting beta-cells against these effects, thus providing a means of intervening in the pathogenesis of IDDM.
Sjöholm
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Rolf Lufts centrum för diabetesforskning, Karolinska sjukhuset, Stockholm. ake@enk.ks.se
D017209:Apoptosis; D015551:Autoimmunity; D016923:Cell Death; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D009569:Nitric Oxide / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D009569:Nitric Oxide
Interleukin-1 och kvävemonoxid inblandade i uppkomst av diabetes.