Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery.
OBJECTIVE
To discover a more reliable method of performing delayed suture adjustment as a basis to investigate whether delayed adjustment actually provides more stable results. In order to prevent the formation of postoperative adhesions and delay the time of adjustment, an animal study was performed to determine the combined effect of physical barriers, Viscoat and Interceed, and a pharmacological agent, 5-fluorouracil (5-FU).


METHODS
38 rabbit eyes were divided into three groups. After recession of the superior rectus muscle (SRM), 5-FU was applied beneath and over the SRM in group 5-FU. Group I-f had Interceed and 5-FU and group I-fv, Interceed, 5-FU, and Viscoat. Delayed adjustment was performed once on each SRM at 1, 2, and 3 weeks postoperatively. The possible length and the necessary force to adjust as well as the degree of adhesions were recorded.


RESULTS
5-FU delayed the adjustment for up to 1 week after surgery in three out of four eyes. Combined use of Interceed and 5-FU could delay the adjustment for up to 1 week after surgery in three out of five eyes. Addition of Viscoat could delay the adjustment for up to 1 week after surgery in four out of five eyes. Adjustment was possible on only one of four eyes thereafter.


CONCLUSIONS
Combined use of Interceed, 5-FU, and Viscoat could delay the adjustment in rabbits until 1 week postoperatively.
Hwang
J M
JM
Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Chang
B L
BL
D000222:Adaptation, Physiological; D000818:Animals; D000963:Antimetabolites / Q000627:therapeutic use*; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D002807:Chondroitin / Q000627:therapeutic use; D002809:Chondroitin Sulfates; D003229:Conjunctival Diseases / Q000209:etiology; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use*; D006820:Hyaluronic Acid / Q000627:therapeutic use; D011184:Postoperative Period; D011817:Rabbits; D013285:Strabismus / Q000188:drug therapy* / Q000601:surgery; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D000963:Antimetabolites; D002483:Cellulose, Oxidized; D004338:Drug Combinations; C060002:INTERCEED; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates; D005472:Fluorouracil