Possible relationship between conditions associated with chronic hypoxia and brain mitochondrial DNA deletions; reduction of genomic 8-hydroxyguanine levels in human brain tissues containing elevated levels of the human mitochondrial DNA4977 deletion.
Zullo
S J
SJ
Laboratory of Biochemical Genetics, National Institute of Mental Health, National Institutes of Health, Building 10, Room 2D54, Bethesda, Maryland, 20892, USA. zullo@helix.nih.gov
Cerritos
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Merril
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D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002908:Chronic Disease; D018736:DNA Adducts / Q000032:analysis / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D003848:Deoxyguanine Nucleotides / Q000032:analysis; D015894:Genome, Human; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D017384:Sequence Deletion; D013223:Statistics as Topic
D018736:DNA Adducts; D004272:DNA, Mitochondrial; D003848:Deoxyguanine Nucleotides; D017382:Reactive Oxygen Species; C024829:8-hydroxyguanine; D006147:Guanine