title: H+/K+-adenosine triphosphatase mRNA in gastric fundic gland mucosa in patients infected with Helicobacter pylori.
abstract: BACKGROUND
  How Helicobacter pylori infection affects gastric acid secretion has not been made clear. This study aimed to elucidate the effects of H. pylori infection on H+/K+-adenosine triphosphatase (ATPase) mRNA in gastric fundic gland mucosa.
  
  
  METHODS
  Twenty patients with chronic gastritis and H. pylori infection were treated with lansoprazole and antibiotics. Before and 1 month after treatment gastroduodenoscopy was performed, and changes in the amount of H+/K+-ATPase mRNA in the fundic gland mucosa, gastric juice pH, and serum gastrin levels were determined.
  
  
  RESULTS
  The amount of H+/ K+-ATPase mRNA in the fundic gland mucosa was increased in patients with eradication of H. pylori, in whom significant decreases in gastric juice pH and serum gastrin levels were observed. No significant changes were observed in patients without eradication of H. pylori.
  
  
  CONCLUSIONS
  These results suggest that one of the mechanisms by which H. pylori infection suppresses acid secretion is by the inhibition of proton pump synthesis in parietal cells.
authors.affiliation: First Dept. of Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Furuta
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Takashima
authors.forename: N
authors.initials: N
authors.lastname: Shirai
authors.forename: F
authors.initials: F
authors.lastname: Xiao
authors.forename: H
authors.initials: H
authors.lastname: Futami
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Hanai
authors.forename: E
authors.initials: E
authors.lastname: Kaneko
mesh_terms: D017931:DNA Primers; D004359:Drug Therapy, Combination; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology* / Q000382:microbiology; D005756:Gastritis / Q000201:enzymology / Q000382:microbiology*; D017506:H(+)-K(+)-Exchanging ATPase / Q000096:biosynthesis*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000201:enzymology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D017506:H(+)-K(+)-Exchanging ATPase