A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon.
The aim of this study was to assess the efficacy of iron depletion obtained by phlebotomy to enhance interferon response in 11 patients who had failed to respond to a standard 3-month interferon treatment. Despite a significant effect on serum aminotransferase levels, there was no effect on viremia, and iron depletion was unable to trigger interferon response.
Guyader
D
D
Clinique des Maladies du Foie et Inserm U49, Laboratoire de Virologie de l'Université de Rennes, France.
Boucher
E
E
André
P
P
Even
C
C
Cottereau
J
J
Bianchi
A
A
Gasser
P
P
Mendler
M H
MH
Deugnier
Y
Y
Brissot
P
P
D000328:Adult; D004351:Drug Resistance; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007501:Iron / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D010865:Pilot Projects; D012367:RNA, Viral / Q000097:blood
D012367:RNA, Viral; D007372:Interferons; D007501:Iron