title: P300 and disability of daily life in schizophrenia.
abstract: 1. The relationship between the P300 component of event-related potentials and disability of daily life was examined in schizophrenia. The subjects were 26 chronic schizophrenic patients. 2. Disability of daily life was assessed by using the Life Assessment Scale for Mental Illness (LASMI). 3. Auditory event-related potentials were recorded during a standard oddball task. 3. P300 amplitude correlated negatively with general psychopathology scale of PANSS (r = -0.416) and Work of LASMI (r = -0.417). P300 latency did not correlate with any of PANSS or LASMI score. 4. These results indicate that P300 amplitude can be an index for disability of daily life in schizophrenia.
authors.affiliation: Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iwanami
authors.forename: M
authors.initials: M
authors.lastname: Yamashina
authors.forename: H
authors.initials: H
authors.lastname: Kazamatsuri
authors.forename: K
authors.initials: K
authors.lastname: Kamijima
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D015415:Biomarkers; D006233:Persons with Disabilities / Q000145:classification*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000145:classification / Q000503:physiopathology*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers