Palm vitamin E improves bone metabolism and survival rate in thyrotoxic rats.
The effects of vitamin E derived from palm oil on bone turnover in thyrotoxic rats were studied. Palm vitamin E reduced bone resorption to a greater extent than bone formation in thyrotoxic rats, suggesting a net reduction in bone loss. The action of palm vitamin E is probably due to its antioxidant properties. Survival rates were also significantly increased in thyrotoxic rats given palm vitamin E, suggesting the role of free radicals in the overall morbidity and mortality in thyrotoxicosis.
Ima-Nirwana
S
S
Department of Pharmacology, Universiti Kebang saan Malayasia, Kuala Lampur. imasoel@pksun5.media.ukm.my
Kiftiah
A
A
Sariza
T
T
Gapor
M T
MT
Khalid
B A
BA
D000704:Analysis of Variance; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013958:Thyroid Crisis / Q000097:blood* / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
D015415:Biomarkers; D014284:Triiodothyronine; D014810:Vitamin E; D013974:Thyroxine; D002118:Calcium