[Interaction between angiotensin II and other local vasoactive substances].
Recent advances in the molecular characterization for angiotensin II (A II) related to nitric oxide, endothelin-1, prostaglandin, and adrenomedullin are reviewed. A II, the main biological active peptide of the renin-angiotensin system, plays an important role in cardiovascular homeostasis such as regulation of blood pressure and tissue remodeling. A II produces vasoconstriction by a direct action on smooth muscle cells via AT1 receptor. This action can be due to circulating A II but also to A II produced within the tissues. Nitric oxide and adrenomedullin are potent vasorelaxant substances. These substances may play a role as local antimigration factors, and antagonize the effect of A II. Whereas endothelin-1 and thromboxane A2 are vasoconstrictor substances, and may have a role as growth factors. A II and these vasoactive substances mutually exert several biological actions in cardiovascular diseases.
Kobayashi
N
N
Department of Medicine, Dokkyo University School of Medicine.
Matsuoka
H
H
D053607:Adrenomedullin; D000804:Angiotensin II / Q000502:physiology*; D016232:Endothelins / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D010455:Peptides / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
D016232:Endothelins; D010455:Peptides; D011453:Prostaglandins; D014665:Vasodilator Agents; D000804:Angiotensin II; D053607:Adrenomedullin; D009569:Nitric Oxide