title: Zinc alleviates thermal hyperalgesia due to partial nerve injury.
abstract: Zinc has recently been shown to alleviate inflammatory hyperalgesia. In the present study, we showed that intrathecal, intraplantar or systemic injection of zinc chloride significantly relieved thermal hyperalgesia in rats with sciatic nerve injury. Alleviation of thermal hyperalgesia was dose dependent in each case, although higher doses were required for i.p. injections (ED50 = 13.6 nmole) than for intrathecal (ED50 = 0.05 nmole) or intraplantar injections (ED50 = 0.3 nmole). Neither intrathecal nor intraplantar zinc chloride influenced thermal nociception in normal rats without nerve injury. The results provide the first evidence that zinc alleviates neuropathic hyperalgesia.
authors.affiliation: School of Anatomy, University of New South Wales, Sydney, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Liu
authors.forename: J S
authors.initials: JS
authors.lastname: Walker
authors.forename: D J
authors.initials: DJ
authors.lastname: Tracey
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005528:Foot; D006358:Hot Temperature; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007278:Injections, Spinal; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D009414:Nerve Growth Factors; D015032:Zinc