title: Lack of antilipolytic effect of lactate in subcutaneous abdominal adipose tissue during exercise.
abstract: The purpose of our study was to evaluate the potential inhibition of adipose tissue mobilization by lactate. Eight male subjects (age, 26. 25 +/- 1.75 yr) in good physical condition (maximal oxygen uptake, 59.87 +/- 2.77 ml. kg-1. min-1; %body fat, 10.15 +/- 0.89%) participated in this study. For each subject, two microdialysis probes were inserted into abdominal subcutaneous tissue. Lactate (16 mM) was perfused via one of the probes while physiological saline only was perfused via the other, both at a flow rate of 2.5 microl/min. In both probes, ethanol was also perfused for adipose tissue blood flow estimation. Dialysates were collected every 10 min during rest (30 min), exercise at 50% maximal oxygen consumption (120 min), and recovery (30 min) for the measurement of glycerol concentration. During exercise, glycerol increased significantly in both probes. However, no differences in glycerol level and ethanol extraction were observed between the lactate and control probes. These findings suggest that lactate does not impair subcutaneous abdominal adipose tissue mobilization during exercise.
authors.affiliation: Département des Sciences de l'Activité Physique, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada G9A 5H7. Francois_Trudeau@uqtr.uquebec.ca
authors.forename: F
authors.initials: F
authors.lastname: Trudeau
authors.forename: S
authors.initials: S
authors.lastname: Bernier
authors.forename: I
authors.initials: I
authors.lastname: de Glisezinski
authors.forename: F
authors.initials: F
authors.lastname: Crampes
authors.forename: F
authors.initials: F
authors.lastname: Dulac
authors.forename: D
authors.initials: D
authors.lastname: Rivière
mesh_terms: D000005:Abdomen / Q000502:physiology; D000273:Adipose Tissue / Q000098:blood supply / Q000378:metabolism*; D000328:Adult; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006728:Hormones / Q000097:blood; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008066:Lipolysis / Q000502:physiology*; D008297:Male; D017551:Microdialysis; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D005230:Fatty Acids, Nonesterified; D006728:Hormones; D007773:Lactates; D005990:Glycerol