The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth of angiosarcoma in mice.
BACKGROUND
Endothelial malignancies, such as angiosarcoma and hemangioendothelioma, are often resistant to chemotherapy and surgery, and may result in death. Improved means of therapy are needed for these disorders.


OBJECTIVE
We wanted to determine whether angiosarcoma can be treated with angiogenesis inhibitors in mice.


METHODS
Mice were inoculated with a cell line that gives rise to angiosarcoma and were treated with the angiogenesis inhibitors 2-methoxyestradiol and TNP-470. Response to therapy was monitored by measurement of tumors.


RESULTS
TNP-470 caused an 84% reduction in tumor size, and 2-methoxyestradiol caused a 68% reduction in tumor size.


CONCLUSIONS
Angiogenesis inhibitors are highly effective in treatment of angiosarcoma in mice. Clinical trials of these agents in humans with angiosarcoma and hemangioendothelioma are warranted.
Arbiser
J L
JL
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. jarbise@emory.edu
Panigrathy
D
D
Klauber
N
N
Rupnick
M
M
Flynn
E
E
Udagawa
T
T
D'Amato
R J
RJ
D000077584:2-Methoxyestradiol; D000818:Animals; D003510:Cyclohexanes; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006390:Hemangioendothelioma / Q000098:blood supply / Q000188:drug therapy; D006394:Hemangiosarcoma / Q000098:blood supply* / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009389:Neovascularization, Pathologic / Q000473:pathology / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D012717:Sesquiterpenes / Q000627:therapeutic use*
D003510:Cyclohexanes; D012717:Sesquiterpenes; D004958:Estradiol; D000077584:2-Methoxyestradiol; D000077609:O-(Chloroacetylcarbamoyl)fumagillol