title: [Daytime mechanical ventilation in chronic ventilatory insufficiency].
abstract: BACKGROUND
  Nocturnal hypoventilation is associated with chronic ventilatory insufficiency (CVI). Noninvasive mechanical ventilation (NIV) performed overnight relieves symptoms of hypoventilation and improves daytime blood gases in CVI. In order to test whether the efficacy of NIV depends on its being applied during sleep we conducted a prospective case controlled study comparing daytime mechanical ventilation (DV) in awake patients with nocturnal mechanical ventilation (NV) given in equal quantities.
  
  
  METHODS
  We enrolled 34 clinically stable patients (age: 56.1 +/- 12.1 years, 20 female) with CVI due to both restrictive lung and chest wall disorders and neuromuscular disease. Using a prospective case-control design, matched subjects were allocated alternately to DV and NV.
  
  
  CONCLUSIONS
  There were no significant differences between the groups in the improvement of the measured parameters; (e.g. PaCO2; DV: from 57.6 +/- 4.3 to 44.0 +/- 4.6 mm Hg, NV: from 55.5 +/- 3.5 to 45.0 +/- 4.1 mm Hg, p < 0.0001). We conclude that in many respects, when compared to NV, DV in awake patients is equally effective for the treatment of CVI.
authors.affiliation: Krankenhaus Kloster Grafschaft, Zentrum für Pneumologie, Beatmungs- und Schlafmedizin, Schmallenberg-Grafschaft. Bernd.Schoenhofer@t-online.de
authors.forename: B
authors.initials: B
authors.lastname: Schönhofer
authors.forename: M
authors.initials: M
authors.lastname: Geibel
authors.forename: P
authors.initials: P
authors.lastname: Haidl
authors.forename: D
authors.initials: D
authors.lastname: Köhler
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000628:therapy*; D012122:Ventilators, Mechanical
vernacular_title: Nichtinvasive Beatmung am Tag bei Patienten mit chronisch ventilatorischer Insuffizienz.