[The injury of human lung cultured vascular endothelial cells in vitro added to burned skin extracts].
Human lung cultured vascular endothelial cells model was established in vitro. Two kinds of skin extracts (human burned skin extracts, HBSE, and human natural skin extracts, HNSE) were added to cultured endothelial cells. The results showed that HBSE exerted toxic effect on endothelial cells in vitro. There were significantly higher contents of ET-1, NO, TNF-alpha, and abnormal structural changes in EC in the HBSE group.
Kong
Q
Q
Burn Unit, 304th Hospital, People's Liberation Army, Beijing.
Zhu
Z
Z
Jia
X
X
D002056:Burns / Q000473:pathology; D002478:Cells, Cultured; D019332:Endothelin-1 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000098:blood supply; D009569:Nitric Oxide / Q000378:metabolism*; D012867:Skin / Q000737:chemistry; D014020:Tissue Extracts / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D019332:Endothelin-1; D014020:Tissue Extracts; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide