title: Long pulse biphasic electrical stimulation of denervated muscle.
abstract: In recent years a number of studies have employed long pulse biphasic stimulation as a treatment for denervated muscle to improve tissue quality and in some cases to improve contractile capability sufficient to restore function. However, in the U.K., this treatment is yet to be widely adopted clinically. A 5 subject, case based pilot study of long pulse biphasic direct stimulation of peripheral limb denervated muscle is being conducted and its effect on the tissue evaluated by measurement of muscle bulk, limb blood flow, and skin temperature. In cases of partial denervation. trapezoidal shaped pulses are used to minimize sensory and motor nerve fiber recruitment.
authors.affiliation: University of Surrey, Biomedical Engineering Group, Guildford, UK.
authors.forename: A H
authors.initials: AH
authors.lastname: Woodcock
authors.forename: P N
authors.initials: PN
authors.lastname: Taylor
authors.forename: D J
authors.initials: DJ
authors.lastname: Ewins
mesh_terms: D001132:Arm / Q000294:innervation / Q000502:physiology; D001917:Brachial Plexus / Q000293:injuries; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000294:innervation / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000098:blood supply / Q000294:innervation* / Q000502:physiology; D009133:Muscular Atrophy / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D009412:Nerve Fibers / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000628:therapy*; D010865:Pilot Projects; D010992:Plethysmography, Impedance; D011999:Recruitment, Neurophysiological / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D012881:Skin Temperature / Q000502:physiology; D013119:Spinal Cord Injuries / Q000534:rehabilitation; D013817:Thermography