[An assessment of neuronal regeneration in neural anastomoses by synthetic guide and biological systems and insulin administration: an experimental study in the rat].
The synthetic and biological nerve guide regeneration gives interesting perspective of use in making artificial conduits for peripheral nerve reconstruction. In sixty Wistar rats, under general anesthesia and with microsurgical technique, the ischiatic nerve was isolated. On the right side a segment of the nerve was removed in order to create a 10 mm gap. The defect then repaired using the conduit. Control were performed at 20, 90, 180 days and consisted in histological microscopy and electromyography investigation. The regeneration of the nerve fibers in the lumen of the conduit was not significantly different on the contralateral nerve limb.
Vellucci
R
R
Istituto di III Clinica Chirurgica, Università degli Studi La Sapienza, Roma.
Toppi
L
L
Capuano
L G
LG
Picozzi
P
P
Bove
A
A
Pasciuto
A
A
Lucci
S
S
Corbellini
L
L
D000287:Administration, Topical; D000714:Anastomosis, Surgical / Q000295:instrumentation / Q000379:methods; D000818:Animals; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology* / Q000601:surgery*; D013997:Time Factors
D007004:Hypoglycemic Agents; D007328:Insulin; D011994:Recombinant Proteins
Valutazione della rigenerazione neuronale nelle anastomosi nervose mediante sistemi tutoriali sintetici, biologici e somministrazione di insulina: studio sperimentale sul ratto.