The human poly(ADP-ribose) glycohydrolase maps to chromosome 10q11.23-21.1 by fluorescence in situ hybridization.
Poly(ADP-ribose) glycohydrolase (PARG) digests poly(ADP-ribose), which is synthesized by poly(ADP-ribose) polymerase (PARP) after DNA damage. We mapped the human poly(ADP-ribose) glycohydrolase gene to chromosome 10q11.23-21.1 by fluorescence in situ hybridization analysis. Since chromosomal rearrangements in thyroid papillary carcinoma and loss of heterozygosity in glioblastoma are frequently observed in this region, genetic alteration of PARG could be implicated in these diseases.
Shimokawa
T
T
Biochemistry Division, University of Tokyo.
Masutani
M
M
Nozaki
T
T
Nakagama
H
H
Araki
S
S
Aoki
Y
Y
Sugimura
T
T
D001483:Base Sequence; D002291:Carcinoma, Papillary / Q000235:genetics; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D004249:DNA Damage; D005909:Glioblastoma / Q000235:genetics; D006026:Glycoside Hydrolases / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D019656:Loss of Heterozygosity; D008969:Molecular Sequence Data; D013964:Thyroid Neoplasms / Q000235:genetics; D014178:Translocation, Genetic
D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase