Cellular and molecular mechanisms of memory: the LTP connection.
Studies of the cellular and molecular mechanisms of memory formation have focused on the role of long-lasting forms of synaptic plasticity such as long-term potentiation (LTP). A combination of genetic, electrophysiological and behavioral techniques have been used to examine the possibility that LTP is a cellular mechanism of memory storage in the mammalian brain. Although a definitive answer remains elusive, it is clear that in many cases manipulations that alter LTP alter memory, and training regimens that produce memory can produce LTP-like potentiation of synaptic transmission.
Miller
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Department of Neurosciences University of California San Diego School of Medicine 9500 Gilman Drive, La Jolla, California 92093-0691, USA.
Mayford
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D000818:Animals; D006801:Humans; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics
D016194:Receptors, N-Methyl-D-Aspartate