title: [Is the J-curve important in the treatment of the patient with arterial hypertension?].
abstract: Stroke morbidity and mortality is related to arterial hypertension. The benefit of arterial hypertension therapy is evident, but the same is not true for coronary artery disease prevention. In recent years, some authors have suggested that as excessive drop in diastolic arterial pressure with therapy could be deleterious. The lack of objective evidence of such an effect required a special study design. It was achieved with the Hot study. After this study, we can probably conclude that the j-curve effect may not be relevant in arterial hypertension therapy.
authors.affiliation: Hospital Egas Moniz, Lisboa.
authors.forename: J
authors.initials: J
authors.lastname: Nazaré
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000401:mortality / Q000517:prevention & control; D003327:Coronary Disease / Q000401:mortality; D003971:Diastole / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality; D012083:Renin / Q000097:blood
chemical_list: D015415:Biomarkers; D012083:Renin
vernacular_title: A curva J é importante no tratamento do doente com hipertensão arterial?