title: Splenic and hepatic hemozoin in mice after malaria parasite clearance.
abstract: Hemozoin (malaria pigment) is found in many tissues during malaria infections. In mice that have self-cured from Plasmodium yoelii and Plasmodium chabaudi infections, liver hemozoin concentration and total content decreased for 6-9 mo after parasite clearance. However, both spleen hemozoin concentration and total hemozoin content increased dramatically during this time period. Thus, hemozoin or hemozoin-laden macrophages continue to accumulate in murine spleens for at least several months after malaria parasitemia becomes undetectable.
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Levesque
authors.forename: A D
authors.initials: AD
authors.lastname: Sullivan
authors.forename: S R
authors.initials: SR
authors.lastname: Meshnick
mesh_terms: D000818:Animals; D006420:Hemeproteins / Q000032:analysis*; D008099:Liver / Q000737:chemistry* / Q000473:pathology; D008288:Malaria / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size; D010860:Pigments, Biological / Q000032:analysis; D016788:Plasmodium chabaudi / Q000502:physiology*; D010967:Plasmodium yoelii / Q000502:physiology*; D013154:Spleen / Q000737:chemistry* / Q000473:pathology
chemical_list: D006420:Hemeproteins; D010860:Pigments, Biological; C020753:hemozoin