[Implication of HARP in angiogenesis and possible therapeutic role].
HARP (heparin affin regulatory peptide), also called pleiotrophin (PTN), belongs to the heparin binding growth factors (HBGFs) family. Several new data suggest a role for HARP during the various stages of angiogenesis. In vivo, HARP is localised in endothelial cells of blood capillaries. In vitro, HARP displays mitogenic activity on endothelial cells, induces the formation of capillary-like structures in collagen gel, and degrades extracellular matrix via stimulation of plasminogen activator activity. HARP is also involved in neoangiogenesis during tumor progression. This review discusses the possible role of HARP in tumor angiogenesis and its therapeutic implications.
Delbe
J
J
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires (CRRET), UPRESA CNRS 7053, Université Paris Val-de-Marne, Creteil, France.
Katsoris
P
P
Milhiet
P E
PE
Barritault
D
D
Caruelle
D
D
Courty
J
J
D000595:Amino Acid Sequence; D002196:Capillaries / Q000378:metabolism; D002352:Carrier Proteins / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D008934:Mitogens / Q000502:physiology*; D008969:Molecular Sequence Data; D009389:Neovascularization, Pathologic; D017433:Protein Structure, Secondary
D002352:Carrier Proteins; D016207:Cytokines; D008934:Mitogens; C066845:pleiotrophin
Implication de l'HARP dans l'angiogenèse et rôle thérapeutique possible.