Is transposition of the great arteries a consequence of maternal hormone imbalance? Evidence from the sex ratios of relatives of probands.
Transposition of the great arteries occurs more often to males than females: moreover there is reportedly an excess of males among the unaffected relatives of probands. This is construed as evidence that maternal intrauterine hormone levels play a role in the aetiology of this malformation.
James
W H
WH
The Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, U.K.
D004967:Estrogens / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D008297:Male; D010375:Pedigree; D011247:Pregnancy / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D012744:Sex Ratio; D013739:Testosterone / Q000378:metabolism; D014188:Transposition of Great Vessels / Q000196:embryology* / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D006062:Gonadotropins; D013739:Testosterone; D011374:Progesterone