Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. II. Inhibitory effect of the activated carbon fiber adsorbent 'Aqualen' on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.
Two-month-old female LIO rats were given N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) with tap water in a concentration of 100 mg/l for 12 months (groups 1 and 2) or were kept without the carcinogen treatment (groups 3 and 4). From the first day of exposure to MNNG rats from groups 2 and 3 were given activated carbon fiber adsorbent Aqualen in their diet five times per week together with lab chow in a daily dose of 100 mg/kg of body weight. The experiment was finalized 16 months after first exposure to the carcinogen. The total stomach adenocarcinoma incidence was 43% in group 1 and 39% in group 2, whereas invasive stomach adenocarcinomas occurred in 36% and 8% of rats from groups 1 and 2, respectively (P < 0.05). Tumors other then stomach sites (duodenum and liver) only developed in rats from group 1 (29%). No lesions were observed in rats exposed to Aqualen without MNNG. Thus, our results demonstrate the inhibitory effect of the activated carbon fiber adsorbent Aqualen on stomach carcinogenesis in rats.
Anisimov
V N
VN
Laboratory of Experimental Tumors, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia. anisimov@anisimov.spb.ru
Zabezhinski
M A
MA
Popovich
I G
IG
Lieberman
A I
AI
Shmidt
J L
JL
D000327:Adsorption; D000818:Animals; D002244:Carbon / Q000627:therapeutic use*; D002273:Carcinogens / Q000633:toxicity*; D004043:Dietary Fiber / Q000627:therapeutic use*; D005260:Female; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D002273:Carcinogens; D004043:Dietary Fiber; D008769:Methylnitronitrosoguanidine; D002244:Carbon