title: [Morphine decreases the voltage sensitivity of the slow sodium channels].
abstract: Morphine was shown to decrease in a dose-dependent manner the effective charge transfer in tetrodotoxin-resistant (TTXr) sodium channel activation system in short-term cultured dorsal root ganglion cells. Morphine seems to interact with opioid receptors because of total block of the binding by naloxone and naltrexone. Neither activating, nor inhibiting G-protein agents exerted any effect on this process. The morphine signal was blocked by extracellular application of 2 x 10(-4) M ouabain. The findings suggest existence of sodium signalling pathway involving receptors, Na+, K(+)-ATPase and the TTXr sodium channels.
authors.affiliation: Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: B V
authors.initials: BV
authors.lastname: Krylov
authors.forename: A V
authors.initials: AV
authors.lastname: Derbenev
authors.forename: S A
authors.initials: SA
authors.lastname: Podzorova
authors.forename: M I
authors.initials: MI
authors.lastname: Liudyno
authors.forename: A V
authors.initials: AV
authors.lastname: Kuz'min
authors.forename: N L
authors.initials: NL
authors.lastname: Izvarina
mesh_terms: D000818:Animals; D002462:Cell Membrane; D002478:Cells, Cultured; D005727:Ganglia, Spinal / Q000166:cytology; D009020:Morphine / Q000378:metabolism / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists / Q000378:metabolism; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D011957:Receptors, Opioid; D015222:Sodium Channels; D013779:Tetrodotoxin; D009020:Morphine; D000254:Sodium-Potassium-Exchanging ATPase
vernacular_title: Morfine umen'shaet chuvstvitel'nost' k potentsialu medlennykh natrievykh kanalov.