[Involvement of the intracellular regulatory systems in the adaptive effect of short-term anoxia in vitro].
Moderate long-term activation of intracellular regulatory system (IRS) was found to be manifested as an increase in the bound calcium content and intensity of the phosphoinositide metabolism following a 30-minute re-oxygenation in the rat olfactory cortex perfused slices. The perfusate induced a similar activation in intact slices-recipients. Long-term anoxia induced a biphasic NMDA-dependent increase in intracellular free Ca2+ and pathogenic hyperactivity of the IRS. The pathogenic events could be prevented by preconditioning of the slices by either short-term anoxia (STA) or post-STA donor perfusate.
Semenov
D G
DG
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Tiul'kova
E I
EI
Samoĭlov
M O
MO
Lazarevich
E V
EV
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015687:Cell Hypoxia; D066298:In Vitro Techniques; D007424:Intracellular Fluid / Q000378:metabolism*; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D009833:Olfactory Pathways / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D018377:Neurotransmitter Agents; D010716:Phosphatidylinositols; D002118:Calcium
Uchastie vnutrikletochnykh reguliatornykh sistem v adaptivnykh éffektakh kratkosrochnoĭ anoksii in vitro.