Presenilins in their infancy.
Familial forms of Alzheimer's disease are caused by mutations in the genes encoding the presenilins, which are integral membrane proteins. Presenilins have been shown to interact with beta-amyloid precursor proteins and Notch receptors. Several recent studies have examined the role of presenilins in Notch processing.
Schweisguth
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Ecole Normale Supérieure, CNRS ATIPE UMR8544, 46, rue d'Ulm, 75230, Paris, Cedex 05, France. schweisg@wotan.ens.fr
D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D053764:Presenilin-1; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch
D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D011956:Receptors, Cell Surface; D051880:Receptors, Notch