[Pathophysiological bases, clinical results and indications for surgical treatment in Parkinson disease].
We review the present status of surgery for Parkinson's disease. Surgical options for Parkinson's disease are rapidly spanding. The main objectives of surgical techniques are to restore the dopaminergic deficit in the striatum (transplantation) and to normalize the neuronal activity of the subthalamic-pallidal circuit (pallidotomy and deep brain stimulation). Whereas cell transplantation is still considered an experimental procedure, ablative procedures and deep brain stimulation are widely used. Both types of surgical procedures are supported by strong scientific data. However, much work remains to be done in order to understand several aspects not clearly elucidated at present. The results and current indications for pallidotomy and deep brain stimulation are analyzed.
Obeso
J A
JA
Centro de Neurología y Neurocirugía funcional, Clínica Quirón, San Sebastián. neurotax@jet.es
Linazasoro
G
G
Gorospe
A
A
Rodríguez
M C
MC
Guridi
J
J
Ramos
E
E
D001921:Brain / Q000502:physiology; D003342:Corpus Striatum / Q000601:surgery*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D016332:Fetal Tissue Transplantation; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000637:transplantation; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery*; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000196:embryology / Q000637:transplantation; D013788:Thalamus / Q000601:surgery*; D016896:Treatment Outcome
Bases fisiopatológicas, resultados clínicos e indicaciones del tratamiento quirúrgico de la enfermedad de Parkinson.