[Ethanol modifies the ion selectivity of sodium channels in the rat sensory neurons].
Ethanol was shown to decrease the reversal potential of tetrodotoxin-resistant (TTXr) and TTX-sensitive channels in short-term culture of the dorsal root ganglion cells. The ethanol led to alterations in ionic selectivity of the TTXr channels (its shifting from the X-th Eisenmann selectivity sequence to the XI-th one). The data obtained suggest that the findings were due to selectivity filter modification because of disturbed hydrogen bounds in the channel macromolecule.
Krylov
B V
BV
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia.
Vilin
Iu Iu
IuIu
Katina
I E
IE
Podzorova
S A
SA
D000818:Animals; D002412:Cations / Q000378:metabolism*; D002478:Cells, Cultured; D000431:Ethanol / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000166:cytology; D015640:Ion Channel Gating; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D015222:Sodium Channels / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology
D002412:Cations; D015222:Sodium Channels; D000431:Ethanol; D013779:Tetrodotoxin
Etanol modifitsiruet ionnuiu izbiratel'nost' natrievykh kanalov sensornykh neĭronov krysy.