title: Intrabronchial Aspergillus nidulans infection in an immunocompetent man.
abstract: We describe the first report of intrabronchial Aspergillus nidulans infection in an immunocompetent patient, which fit the description of bronchocentric granulomatosis. The patient had a history of accidental aspiration of light grade oil. Fiberoptic bronchoscopy revealed that the right B4aii alpha was obstructed. Endobronchial biopsy specimens contained fungal hyphae. The fungus was confirmed to be Aspergillus nidulans by culture. We suspected that aspiration of light grade oil had injured the bronchial mucosa, after which airborne Aspergillus nidulans had entered the lesion and multiplied. Intrabronchial fungal infection can occur in a healthy person without immunologic abnormalities, if a bronchial lesion provides an entry portal.
authors.affiliation: Department of Pulmonary Medicine, National Sanatorium Matsue Hospital, Shimane.
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Shishido
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D001233:Aspergillus nidulans / Q000302:isolation & purification*; D001982:Bronchial Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D017964:Itraconazole