title: Anti-telomerase therapy suppressed glioma proliferation.
abstract: In order to determine if telomerase activity contributes to the growth of glioma cells, we constructed an anti-telomerase vector to suppress telomerase expression in glioma cells. The human telomerase (hTR)-antisense vector showed a significant suppression effect. However it did not appear to induce cell death as a stable population of cells survived more than two months following transfection. These results provide evidence that reagents aimed at inhibiting telomerase may represent a useful strategy for suppressing the growth of glioma cells. In addition to telomerase, another mechanism would also maintain telomere length, thus supporting continuous cell proliferation.
authors.affiliation: Department of Neurosurgery, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: R S
authors.initials: RS
authors.lastname: Morrison
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Teramoto
mesh_terms: D002455:Cell Division; D005822:Genetic Vectors; D005910:Glioma / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology*; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000235:genetics; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D016376:Oligonucleotides, Antisense; D019098:Telomerase