Neurotrophin actions during the development of the peripheral nervous system.
Neurotrophins are important regulators of the development and maintenance of the vertebrate nervous system. Besides their well-established role in promoting neuronal survival during development, in vitro data suggest that they can regulate proliferation, survival, and differentiation of precursor cells. Analysis of the developing peripheral nervous system in mouse strains carrying mutations in genes encoding the neurotrophins and their receptors indicate, however, that lack of neurotrophin signalling results in specific neuronal deficits that are primarily due to neuronal death. Many of these deficits occur before final target encounter.
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Departamento de Biología Celular, Universidad de Valenica, Burjasot, Spain. isabel.farinas@uv.es
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D002470:Cell Survival; D019204:GTP-Binding Proteins / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D019950:Mitogen-Activated Protein Kinase 1; D048053:Mitogen-Activated Protein Kinase 6; D020928:Mitogen-Activated Protein Kinases; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology*; D009475:Neurons, Afferent / Q000378:metabolism; D017933:Peripheral Nervous System / Q000254:growth & development* / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D020801:Receptor, Ciliary Neurotrophic Factor; D020917:Receptor, trkA; D020812:Receptor, trkC; D017475:Receptors, Nerve Growth Factor / Q000235:genetics; D013564:Sympathetic Nervous System / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D011518:Proto-Oncogene Proteins; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor; C091581:pan-neurotrophin 1; C078418:developmentally regulated GTP-binding protein; D020794:Receptor Protein-Tyrosine Kinases; D020917:Receptor, trkA; D020812:Receptor, trkC; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1; D048053:Mitogen-Activated Protein Kinase 6; D020928:Mitogen-Activated Protein Kinases; D019204:GTP-Binding Proteins; C073922:neurotrophin 4