title: Effective periodontal treatment in a patient with type IIA von Willebrand's disease: report of a case.
abstract: von Willebrand's disease (vWD) is one of the most common hereditary hemorrhagic disorders. A mild to moderate deficiency of factor VIII and von Willebrand factor (vWf) often is associated with gingival bleeding. In this case report, the periodontal treatment of a patient with vWD is described. A 45-year-old woman with type IIA vWD was referred for periodontal therapy because of an episode of gingival hemorrhage and percussion pain of teeth #18 and #47. The periodontal findings included probing depths ranging from 2 to 6 mm, horizontal bone loss, and Class II furcation involvement of tooth #46. After consultation with a hematologist, apically positioned flap surgery and hemisection were performed on tooth #46 following completion of oral hygiene instruction, scaling and root planing, and endodontic therapy. The patient was given 500 units of factor VIII including vWf multimer 30 minutes before surgery. After healing of the periodontal tissue, prosthodontic treatment was undertaken on the posterior mandibular sextants. At follow-up, the probing depths ranged from 2 to 3 mm, and gingival bleeding on probing was minimal. The patient's children all had vWD. They had mild to moderate periodontitis with probing depths ranging from 2 to 5 mm and gingival bleeding on probing. With the combined efforts of the periodontist and hematologist, effective periodontal treatment can be provided to patients with von Willebrand's disease.
authors.affiliation: Department of Periodontology, Kagoshima University Dental School, Japan. izumiyu@dentb.hal.kagoshima-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: T
authors.initials: T
authors.lastname: Sueda
mesh_terms: D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery / Q000628:therapy; D017266:Dental Prosthesis; D012534:Dental Scaling; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000601:surgery / Q000628:therapy; D005884:Gingival Hemorrhage / Q000601:surgery / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D010353:Patient Education as Topic; D010375:Pedigree; D010510:Periodontal Diseases / Q000601:surgery / Q000628:therapy*; D010514:Periodontal Pocket / Q000601:surgery / Q000628:therapy; D012390:Root Canal Therapy; D016745:Root Planing; D013524:Surgical Flaps; D014842:von Willebrand Diseases / Q000150:complications* / Q000235:genetics; D014841:von Willebrand Factor / Q000627:therapeutic use
chemical_list: D014841:von Willebrand Factor; D005169:Factor VIII