title: A new cytotoxic 2H-pyran compound produced by acid treatment of the fermentation broth of Streptomyces sp.
abstract: A new cytotoxic substance was isolated following acid treatment of fermented broth of a Streptomyces strain numbered MJ915-WF12. The structure was elucidated by spectroscopic analyses to be 5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran. It was thought to be generated by dehydration and ring reformation of the precursor material in cultured broth by acid.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Nosaka
authors.forename: S
authors.initials: S
authors.lastname: Kunimoto
authors.forename: T
authors.initials: T
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Ohsono
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D051379:Mice; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: C120458:5,5-dihydro-4-formyl-6-hydroxy-2-hydroxymethyl-6-methyl-2H-pyran; D000970:Antineoplastic Agents; D003470:Culture Media; D011714:Pyrans