title: Primary progressive aphasia: a case report.
abstract: We report a 69-year-old male patient whose motor aphasia started at the age of 61. The language disability remained isolated and progressed over a period of eight years without any additional cognitive deficits. Computed tomography (CT) and magnetic resonance imaging (MRI) showed moderate cortical atrophy with frontal dominance. Single photon emission tomography (SPECT) showed hypoperfusion in the frontotemporoparietal region, positron emission tomography (PET) demonstrated a global cortical reduction of glucose utilization with a lesser decrement in the occipital lobes. The clinical symptoms and the neuropsychological findings fit the diagnosis of primary progressive aphasia.
authors.affiliation: Department of Neurology, Semmelweis Medical University, Budapest, Hungary.
authors.forename: T G
authors.initials: TG
authors.lastname: Nagy
authors.forename: I
authors.initials: I
authors.lastname: Jelencsik
authors.forename: I
authors.initials: I
authors.lastname: Szirmai
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D013060:Speech; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed