title: Mechanism of induction of follicular atresia after equine chorionic gonadotrophin (eCG) antisera treatment in hypophysectomized eCG-injected hamster model: possible involvement of c-myc and cdc25.
abstract: An intracellular mechanism of induction of apoptosis of granulosa cells implicated in the initiation of experimentally induced atresia of ovarian follicle in hypophysectomized eCG-injected hamster followed by eCG-antisera treatment is proposed. Induction of atresia after withdrawal of injected eCG by eCG-antisera treatment is possibly caused by inadequate level of the gonadotropin-induced growth factor that results in apoptosis of granulosa cells associated with the activation of c-myc requiring cdc25A.
authors.affiliation: Department of Physiology, A. M. College, Calcutta, India.
authors.forename: A R
authors.initials: AR
authors.lastname: Kole
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000276:immunology / Q000494:pharmacology*; D006224:Cricetinae; D005260:Female; D005496:Follicular Atresia / Q000187:drug effects / Q000502:physiology*; D006064:Gonadotropins, Equine / Q000276:immunology / Q000494:pharmacology*; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D007016:Hypophysectomy; D007106:Immune Sera / Q000494:pharmacology; D008954:Models, Biological; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology*; D020687:cdc25 Phosphatases
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D007106:Immune Sera; D016271:Proto-Oncogene Proteins c-myc; D017027:Protein Tyrosine Phosphatases; D020687:cdc25 Phosphatases