In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.
We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
Park
S P
SP
Department of Neurology, Kyungpook National University School of Medicine, Taegu 700-412, South Korea.
Lopez-Rodriguez
F
F
Wilson
C L
CL
Maidment
N
N
Matsumoto
Y
Y
Engel
J
J
D000818:Animals; D005110:Extracellular Space / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012895:Sleep, REM / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D012701:Serotonin