High energy exchange: proteins that make or break phosphoramidate bonds.
Several proteins that catalyze phosphoryl transfer reactions involving phosphohistidine residues have recently been structurally characterized. The architecture of two histidine kinases defines a new protein kinase fold. The diverse folds of several phosphotransfer proteins appear to be designed to foster protein-protein interactions between transfer partners.
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Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 679 Hoes Lane, Piscataway, NJ 08854-5638, USA.
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D000255:Adenosine Triphosphate / Q000378:metabolism; D001412:Bacillus subtilis / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000502:physiology; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology; D018360:Crystallography, X-Ray; D004734:Energy Metabolism; D029968:Escherichia coli Proteins; D006639:Histidine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D000071677:Histidine Kinase; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D000072236:Methyl-Accepting Chemotaxis Proteins; D008958:Models, Molecular; D009097:Multienzyme Complexes; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000737:chemistry / Q000502:physiology; D010766:Phosphorylation; D011487:Protein Conformation; D017510:Protein Folding; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D012808:Sigma Factor; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D000072236:Methyl-Accepting Chemotaxis Proteins; D009097:Multienzyme Complexes; D012808:Sigma Factor; C080951:Spo0F protein, Bacillus subtilis; D014157:Transcription Factors; C092468:spoIIR protein, Bacillus subtilis; C030069:spore-specific proteins, Bacillus; D006639:Histidine; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; C030182:phosphocarrier protein HPr; D000071677:Histidine Kinase; C057843:envZ protein, E coli; C005436:phosphohistidine