title: [Clinical course of idiopathic inflammatory myopathies: complications, survival and prognostic factors].
abstract: OBJECTIVE
  To describe the clinical and epidemiological characteristics, complications, survival and prognostic factors of a series of patients with idiopathic inflammatory myopathy (IIM) diagnosed with homogeneous criteria in the same center.
  
  
  METHODS
  Patients with the diagnosis of IIM during an inclusion period of 20 years were studied. They were classified following the criteria of Bohan and Peter, and Dalakas. Epidemiological, clinical and therapeutical data were obtained in all cases. Evolution and survival were analyzed with the Kaplan-Meier and Cox multiple regression models.
  
  
  RESULTS
  One-hundred thirty-five patients with IIM were included in the study: 32 polymyositis (PM), 90 dermatomyositis (DM) and 13 inclusion body myositis (IBM). Forty-six percent presented some complications attributed to the disease or treatment, and 10 with PM, 29 with DM and 3 with IBM died during the follow-up. The probabilities of survival were 86% the first year, 80% the second year, 71% the fifth year, and 57% the tenth year. Infections and cancer were the main death causes. While survival analyses did not show independent risk factors for PM, advanced age, presence of associated neoplasm, raised erythrocyte sedimentation rate (ESR) and muscle relapse were identified as a poor prognostic indicators for DM, whereas raised ESR and long lasting symptoms prior to diagnosis of the myopathy were for IBM.
  
  
  CONCLUSIONS
  In spite of the therapeutic advances, IIM are still diseases with high mortality and morbidity.
authors.affiliation: Grup d'Investigació Muscular, Servei de Medicina Interna, Hospital Clínic i Provincial.
authors.forename: O
authors.initials: O
authors.lastname: Miró
authors.forename: M
authors.initials: M
authors.lastname: Laguno
authors.forename: J R
authors.initials: JR
authors.lastname: Alonso
authors.forename: J
authors.initials: J
authors.lastname: Casademont
authors.forename: C
authors.initials: C
authors.lastname: Herrero
authors.forename: A
authors.initials: A
authors.lastname: Selva
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Márquez
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
mesh_terms: D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis* / Q000401:mortality; D009369:Neoplasms / Q000150:complications; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
vernacular_title: Evolución de las miopatías inflamatorias idiopáticas: complicaciones, supervivencia y factores pronósticos.