Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds.
Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the exons of E-cadherin by PCR-single-strand conformational polymorphism analysis in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases.
Iida
S
S
Second Department of Surgery, Tokyo Medical and Dental University School of Medicine, Japan.
Akiyama
Y
Y
Ichikawa
W
W
Yamashita
T
T
Nomizu
T
T
Nihei
Z
Z
Sugihara
K
K
Yuasa
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D013274:Stomach Neoplasms / Q000235:genetics*
D015820:Cadherins