Procainamide inhibition of human hepatic degradation of cocaine and cocaethylene in vitro.
Procainamide (PA), a cardioactive drug, inhibited the degradation of both cocaine (COC) and cocaethylene (CE) when either was incubated in human liver homogenates for 3 h at 37 degrees C. PA appeared to enhance the formation of CE when COC and ethanol (ETOH) were incubated together in liver homogenate. These observations are clinically significant because cardiotoxicity is common after COC abuse and because PA may be administered to individuals who use COC alone and with ETOH.
Bailey
D N
DN
Department of Pathology, University of California Medical Center, San Diego 92103-8320, USA.
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D003042:Cocaine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism* / Q000493:pharmacokinetics; D018765:Dopamine Uptake Inhibitors / Q000378:metabolism* / Q000493:pharmacokinetics; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000378:metabolism* / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000494:pharmacology*; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D018765:Dopamine Uptake Inhibitors; D013287:Illicit Drugs; D000431:Ethanol; C066444:cocaethylene; D003042:Cocaine; D011342:Procainamide