Alcohol and genetics: new animal models.
In recent years, it has become increasingly evident that there is a genetic component to alcoholism. Attempts to isolate alcoholism genes have met with modest success, in part because alcoholism is a multigenic trait. Recently, experimental animal models and novel genetic manipulations have provided several clues as to the specific genes involved in alcoholism, and extensive research has identified many genes that might influence responses to alcohol. Although not all of these might be proven to influence drug sensitivity, research has provided evidence for the involvement of a few genes. Ultimately, findings from animal models that investigate the function of specific genes could aid the development of pharmacotherapies to treat alcohol dependence.
Browman
K E
KE
Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, VA Medical Center (R&D12), Portland, OR 97201, USA. browmank@ohsu.edu
Crabbe
J C
JC
D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D051379:Mice; D009154:Mutation; D019655:Quantitative Trait, Heritable; D051381:Rats