title: Outcomes after extrahepatic portosystemic shunt ligation in 49 dogs.
abstract: OBJECTIVE
  To evaluate outcomes after attenuation of extrahepatic portosystemic shunts in dogs using surgical silk.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Case records were reviewed for degree of surgical attenuation, experience of the primary surgeon, perioperative mortality and problems related to persistent portosystemic shunting or shunt ligation. Presence of portosystemic shunting after surgery was evaluated by ammonia tolerance testing, measurement of postprandial serum bile acid, plasma urea and cholesterol concentrations and liver enzyme activity. The influence of age, postocclusion portal pressure, primary surgeon, degree of attenuation and postoperative biochemical findings on the occurrence of postoperative problems was assessed.
  
  
  RESULTS
  The mortality rate was 2.1%. Shunt attenuation was complete in 34% and partial in 66% of dogs. Portal hypertension necessitating ligature removal was encountered in only one dog. Five dogs experienced neurological abnormalities (seizures or ataxia), possibly as a manifestation of 'postligation seizure syndrome'. Postoperative liver function was normal in 78% of dogs, including 70% with partial shunt attenuation. Experience of the surgeon was related positively to outcome after partial attenuation (P = 0.002). Postoperative biochemical evidence of abnormal liver function was the most sensitive predictor of recurrence of clinical signs referable to persistent portosystemic shunting.
  
  
  CONCLUSIONS
  In the hands of an experienced surgeon, surgical attenuation of single extrahepatic shunts was safe and effective, even in animals with partial attenuation. Most dogs with biochemical evidence of persistent shunting suffer relapse of clinical signs within 18 months of surgery. Postligation neurological syndromes of variable intensity may be more common than previously thought.
authors.affiliation: Department of Veterinary Clinical Sciences, University of Sydney, New South Wales.
authors.forename: G B
authors.initials: GB
authors.lastname: Hunt
authors.forename: J
authors.initials: J
authors.lastname: Hughes
mesh_terms: D000641:Ammonia / Q000097:blood; D000818:Animals; D004285:Dogs / Q000002:abnormalities* / Q000601:surgery*; D008026:Ligation / Q000662:veterinary; D011168:Portal System / Q000002:abnormalities* / Q000601:surgery*; D011183:Postoperative Complications / Q000662:veterinary; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000641:Ammonia