Simulations of neuromuscular control in lamprey swimming.
The neuronal generation of vertebrate locomotion has been extensively studied in the lamprey. Models at different levels of abstraction are being used to describe this system, from abstract nonlinear oscillators to interconnected model neurons comprising multiple compartments and a Hodgkin-Huxley representation of the most relevant ion channels. To study the role of sensory feedback by simulation, it eventually also becomes necessary to incorporate the mechanical movements in the models. By using simplifying models of muscle activation, body mechanics, counteracting water forces, and sensory feedback through stretch receptors and vestibular organs, we have been able to close the feedback loop to enable studies of the interaction between the neuronal and the mechanical systems. The neuromechanical simulations reveal that the currently known network is sufficient for generating a whole repertoire of swimming patterns. Swimming at different speeds and with different wavelengths, together with the performance of lateral turns can all be achieved by simply varying the brainstem input. The neuronal mechanisms behind pitch and roll manoeuvres are less clear. We have put forward a 'crossed-oscillators' hypothesis where partly separate dorsal and ventral circuits are postulated. Neuromechanical simulations of this system show that it is also capable of generating realistic pitch turns and rolls, and that vestibular signals can stabilize the posture during swimming.
Ekeberg
O
O
Department of Numerical Analysis and Computing Science, Royal Institute of Technology, Stockholm, Sweden.
Grillner
S
S
D000818:Animals; D001696:Biomechanical Phenomena; D007798:Lampreys / Q000502:physiology*; D008954:Models, Biological; D008959:Models, Neurological; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011597:Psychomotor Performance; D013116:Spinal Cord / Q000502:physiology*; D013550:Swimming / Q000502:physiology*