[Genetical aspects in cerebrovascular disease].
BACKGROUND
Stroke is a pathophysiological heterogeneous syndrome with numerous genetic influences.


METHODS
Previous populational studies had demonstrated the familial correlation. The parental history of stroke has been associated with stroke in the descendant with a significant relative risk of 2. A study of mono- and dizygotic twins found a fivefold risk of stroke among monozygotic compared with dizygotic. Other modifiable and non-modifiable risk factors are involve in cerebrovascular disease. Recently, the gene that codifies the angiotensin converting enzyme has been determine. An insertion/deletion polymorphism of was associated with increased levels of angiotensin converting enzyme. ApoE4 and high levels of homocysteine has been reported as a risk factors for cerebral infarction. Apoptotic mechanisms have recently been discovered in rats models of ischemia. Caspases inhibitors have shown a reduction of 40% in the cerebral infarction area.


CONCLUSIONS
The purpose of this work is to analyze the genetic factors that constitute an influence in stroke.
Saposnik
G
G
Departamento de Neurología, Hospital J.M. Ramos Mejía, Argentina. gsaposnik@yahoo.com
Terzaghi
M A
MA
D000140:Acidosis, Lactic / Q000235:genetics; D001057:Apolipoproteins E / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology; D006710:Homocysteine / Q000097:blood; D006801:Humans; D017241:MELAS Syndrome / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D012307:Risk Factors; D020521:Stroke / Q000201:enzymology / Q000235:genetics*
D001057:Apolipoproteins E; D006710:Homocysteine; D007703:Peptidyl-Dipeptidase A
Aspectos genéticos en la enfermedad cerebrovascular.