title: Amitriptyline-associated seizures in a toddler with Munchausen-by-proxy.
abstract: We describe an unusual case of a toddler diagnosed with an idiopathic seizure disorder that later was proved to be caused by deliberate administration of amitriptyline by his custodian. In spite of seizures associated with widened electrocardiographic wave (QRS) and right axis deviation on the electrocardiogram (EKG), the correct diagnosis eluded clinicians through a series of hospital admissions. Unfortunately, clinicians are quite accustomed to the fact that patients previously diagnosed with epilepsy have seizures and may not investigate other causes of seizure. This allowed classic signs of cyclic antidepressant poisoning to go unrecognized.
authors.affiliation: Oregon Poison Center and Department of Emergency Medicine, Oregon Health Sciences University, Portland 97201-3098, USA. mullinmi@ohsu.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Mullins
authors.forename: C B
authors.initials: CB
authors.lastname: Cristofani
authors.forename: C R
authors.initials: CR
authors.lastname: Warden
authors.forename: J F
authors.initials: JF
authors.lastname: Cleary
mesh_terms: D000639:Amitriptyline / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D017028:Caregivers; D002675:Child, Preschool; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016735:Munchausen Syndrome by Proxy; D012008:Recurrence; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline