[Radiation protective efficacy of alpha-adrenomimetics during local gamma irradiation of the skin].
In experiment with mice and rats radioprotective properties of direct alpha-adrenomimetic drugs: indraline, mesaton (phenylephrine) and naphthyzine (naphazoline) have been investigated by local early and late radiation injuries. The drugs were S. C. and C. administrated at the site of the thigh of the hind of the animal at intervals of 5-8 min locally was irradiated with gamma-60Co-rays in the doses of 26.3-53.7 Gy at a rate of the dose of 1.31-1.54 Gy/min. When S. C. injected the topical effect of the adrenomimetics was higher than the systemic one. In experiment with mice radioprotective efficiency of topical indraline (S. C. 50 and 100 mg/kg) in term of DRF was equal to 1.34 and 1.67 for radiation burn of the skin, 1.56 and 1.91 for 3rd month radiation contracture of the hind and 1.10 and 1.50 for partial amputation of the one. In the same condition the effect of topical mesaton (S. C. 1, 2.5, 5 mg/kg) in term of DRF was accordingly equal to 1.29, 1.49 and 1.62 for early radiation injury, 1.08, 1.20 and 1.46 for 3th month radiation contracture of the hind and 1.0, 1.14, 1.33 for partial amputation of the one; the effect of topical naphthyzine (5 mg/kg) in the term of DRF was 1.36 for early radiation injury. In experiment with rats radioprotective property of systemic indraline (I. M. 100 mg/kg) in the term of DRF was equal to 1.39 for radiation burn of the skin, 1.39 for 6th month radiation contracture of the hind, 1.41 for partial amputation of the one. When C. administrated the effect of topical indraline (5% solution in 50% DMSO or ethyl alcohol solution) in term of DRF was accordingly equal to 1.17 and 1.18 for radiation burn ot the skin, 1.50 and 1.35 for radiation contracture of the hind, 1.41 and 1.28 for amputation of the one. When S. C. administrated the effect of topical and systemic mesaton (2.5 mg/kg) in term of DRF was accordingly equal to 1.30 and 1.04 for radiation burn ot the skin. 1.25 and 1.0 for radiation contracture of the hind, 1.30 and 1.0 for amputation of the one.
Vasin
M V
MV
Institute of Aviation and Space Medicine, Moscow, Russia.
Ushakov
I B
IB
Semenova
L A
LA
Komarova
S N
SN
Kovtun
V Iu
VIu
D000279:Administration, Cutaneous; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D005720:Gamma Rays; D051379:Mice; D009278:Naphazoline / Q000008:administration & dosage / Q000627:therapeutic use*; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D010656:Phenylephrine / Q000008:administration & dosage / Q000627:therapeutic use*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D011855:Radiodermatitis / Q000188:drug therapy*; D051381:Rats; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D010656:Phenylephrine; D009278:Naphazoline
Protivoluchevaia éffektivnost' alpha-adrenomimetikov pri lokal'nom gamma-obluchenii kozhi.