Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases.
Five patients with dysembryoplastic neuroepithelial tumour (DNT) showing extensive secondary haemorrhage, a finding not previously associated with these neoplasms, are described. The clinical presentations, neuroimaging findings, and histopathological features of these patients are reviewed. One patient, a previously asymptomatic 12 year old girl, presented with an acute intracerebral haemorrhage into a DNT. A further four young adults with histories of intractable partial and generalised seizures dating from childhood showed significant chronic haemorrhages within DNT, the MRI appearances in one patient giving a false impression of a cavernoma. Histopathology disclosed vascular abnormalities within these tumours which, together with other factors discussed, may have predisposed these tumours to haemorrhage.
Thom
M
M
Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London.
Gomez-Anson
B
B
Revesz
T
T
Harkness
W
W
O'Brien
C J
CJ
Kett-White
R
R
Jones
E W
EW
Stevens
J
J
Scaravilli
F
F
D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000503:physiopathology*; D018302:Neoplasms, Neuroepithelial / Q000473:pathology / Q000503:physiopathology*