Novel surgical treatment and gastric pathology in diabetic gastroparesis.
OBJECTIVE
Observations are made on four Type 1 diabetic patients with the rare syndrome of intractable vomiting from confirmed gastroparesis, to determine whether radical surgery would alleviate their symptoms and subsequently to examine in detail the gastric histopathology.


METHODS
The surgical approach consisted of an approximate 70% resection of the stomach, including the antrum and pylorus, with closure of the duodenum and restoration of gastrointestinal continuity with a 60-cm Roux-en-Y jejunal loop. Four longstanding Type 1 diabetic patients were examined and treated as described. They were all women in the age range 2741 years with grossly abnormal autonomic function tests in whom other causes for gastric paresis had been excluded.


RESULTS
Vomiting episodes leading to multiple hospital admissions (6-8) in the year preceding surgery were eliminated in three of the four patients, while in the fourth initial success was followed by the need for dialysis for renal failure. Gastric histopathology showed evidence of smooth muscle degeneration and fibrosis, with eosinophilic inclusion bodies (M-bodies) which appear to be unique to this condition. The findings suggest the presence of a gastromyopathy.


CONCLUSIONS
Satisfactory relief of intractable vomiting from diabetic gastroparesis was achieved by a novel radical surgical procedure. Histopathological findings suggest that gastromyopathy may contribute to the production of this syndrome.
Ejskjaer
N T
NT
King's Diabetes Centre, King's College Hospital, London, UK.
Bradley
J L
JL
Buxton-Thomas
M S
MS
Edmonds
M E
ME
Howard
E R
ER
Purewal
T
T
Thomas
P K
PK
Watkins
P J
PJ
D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005355:Fibrosis; D005746:Gastric Emptying; D018589:Gastroparesis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008854:Microscopy, Electron; D009130:Muscle, Smooth / Q000473:pathology; D009431:Neural Conduction; D013270:Stomach / Q000294:innervation / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome; D014630:Vagus Nerve / Q000473:pathology; D014839:Vomiting / Q000628:therapy