title: Working conditions and health effects of ethylene oxide exposure at hospital sterilization sites.
abstract: Ethylene oxide (EtO) is a powerful disinfectant and sterilant for heat-sensitive surgical items and instruments. Its use in hospitals constitutes an important source of occupational exposure that is sometimes underestimated, such as in cases of EtO device malfunction when the safety rules of procedure are not strictly followed or when individual or collective protective equipment is lacking. We carried out a descriptive study of the health care workers who were assigned to EtO sterilization units of the Lille University Hospital Centre in Lille, France (n = 16). Before the modification of the sterilization units in the development of a single, central sterilization site, we studied the workplaces, occupational conditions, and work procedures of the health care workers exposed to EtO. The aim was to assess the risk of EtO overexposure of the workers in order to improve workers' health and security in the future sterilization center. The study was based on a physical examination, a questionnaire covering each subject's personal and occupational history, and a complete ocular examination. For occupational conditions, the studies of each workplace were also performed by the occupational physician. Area and personal breathing air samplings were performed at each exposure site. Fourteen of the 16 operators had posterior and anterior subcapsular lens opacities, three of which seemed to be directly and primarily related to occupational exposure; the other ten seemed to be rather common and compatible with age. High levels of EtO exposure were reported in the oldest site (90 parts per million [ppm] during the changing of the gas bottle), where exposure often exceeded French threshold limits (permissible exposure limit: 1 ppm 8-hour time-weighted average (TWA) in air; short-term excursion limit: 5 ppm 15-minute TWA in air), or the current US recommended and legal exposure limits for EtO advocated by the Occupational Safety and Health Administration and the American Conference of Governmental Industrial Hygienists (permissible exposure limit: 1 ppm 8-hour TWA in air; excursion limit: 5 ppm 15-minute TWA in air), and the National Institute for Occupational Safety and Health standard (recommended exposure limits: 0.1 ppm 8-hour TWA in air; 5 ppm 10-minute TWA in air). The faults in the work processes, such as interruption of the sterilization cycle and disregard for the use of protective devices, were very common.
authors.affiliation: (Centre de Recherches en Santé-Travail-Ergonomie), Service de Médecine du Travail, C.H.R.U. (Centre Hospitalier Regional Universitaire), Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Sobaszek
authors.forename: J C
authors.initials: JC
authors.lastname: Hache
authors.forename: P
authors.initials: P
authors.lastname: Frimat
authors.forename: V
authors.initials: V
authors.lastname: Akakpo
authors.forename: G
authors.initials: G
authors.lastname: Victoire
authors.forename: D
authors.initials: D
authors.lastname: Furon
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects; D004202:Disinfectants / Q000009:adverse effects*; D005027:Ethylene Oxide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000592:standards; D016272:Occupational Health; D010564:Personnel, Hospital; D013242:Sterilization / Q000592:standards; D017132:Workplace
chemical_list: D004202:Disinfectants; D005027:Ethylene Oxide