title: (2E,6R)-8-hydroxy-2,6-dimethyl-2-octenoic acid, a novel anti-osteoporotic monoterpene, isolated from Cistanche salsa.
abstract: (2E,6R)-8-Hydroxy-2,6-dimethyl-2-octenoic acid [(R)-HDOA], a novel monoterpene from Cistanche salsa, a Chinese herb, was found to be an anti-osteoporotic compound. The extract of Cistanche salsa significantly suppressed the bone weight loss in ovariectomized mice, a postmenopausal osteoporosis model. The active substance was then purified by using this osteoporotic model and the chemical structure was determined. The active compound from Cistanche salsa, (R)-HDOA, suppressed the decrease of bone weight and the mechanical strength in the ovariectomized mice. Furthermore, (R)- and (S)-HDOA were synthesized and the activity of each was evaluated. (R)-HDOA suppressed the bone weight loss, although (S)-HDOA did not showed any activity.
authors.affiliation: Sagami Chemical Research Center, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: C
authors.initials: C
authors.lastname: Shinohara
authors.forename: S
authors.initials: S
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Sodeoka
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008968:Molecular Conformation; D009929:Organ Size / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy; D013056:Spectrophotometry, Ultraviolet; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C120173:8-hydroxy-2,6-dimethyl-2-octenoic acid; D004365:Drugs, Chinese Herbal; D013729:Terpenes