Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2.
Sandalwood oil, the essential oil of Santalum album L., was tested for in vitro antiviral activity against Herpes simplex viruses-1 and -2. It was found that the replication of these viruses was inhibited in the presence of the oil. This effect was dose-dependent and more pronounced against HSV-1. A slight diminution of the effect was observed at higher multiplicity of infections. The oil was not virucidal and showed no cytotoxicity at the concentrations tested.
Benencia
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Department of Biological Chemistry, Faculty of Sciences, University of Buenos Aires, Argentina.
Courrèges
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D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D008826:Microbial Sensitivity Tests; D010938:Plant Oils / Q000494:pharmacology*; D014709:Vero Cells; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010938:Plant Oils