title: [Chronobiology of immune system].
abstract: The biological rhythmological programme of the immune system is a constituent of the body's common biological rhythmological programme. Its pattern seems to be genetically determined and reflects the functional status of the system. The chronobiological mechanisms responsible for the regulation of immune functions lie in the presence of certain phasic interrelations between the biological rhythms of the synthesis and production of regulatory agents on the one hand, and those of the receptor system and metabolic potential of immunocompetent cells on the other. The facts given in the paper may be a basis for a chronobiological approach to better understanding the mechanisms of the physiology and pathology of the immune system. The medical significance of study of the structural and temporal pattern of the immune system consists in the development of new techniques for diagnosis, prognosis, therapy, and assessment of risk factors in immunopathological conditions.
authors.forename: V A
authors.initials: VA
authors.lastname: Trufakin
authors.forename: A V
authors.initials: AV
authors.lastname: Shurlygina
authors.forename: T I
authors.initials: TI
authors.lastname: Dergacheva
authors.forename: G I
authors.initials: GI
authors.lastname: Litvinenko
authors.forename: L V
authors.initials: LV
authors.lastname: Verbitskaia
mesh_terms: D000818:Animals; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D006801:Humans; D007107:Immune System / Q000502:physiology*
vernacular_title: Khronobiologiia immunoĭ sistemy.