title: Clinical validation of intravascular ultrasound imaging for assessment of coronary stenosis severity: comparison with stress myocardial perfusion imaging.
abstract: OBJECTIVE
  To validate intravascular ultrasound (IVUS) measurements for differentiating functionally significant from nonsignificant coronary stenosis.
  
  
  BACKGROUND
  To date, there are no validated criteria for the definition of a flow-limiting coronary artery stenosis by IVUS.
  
  
  METHODS
  Preinterventional IVUS imaging (30-MHz imaging catheter) of 70 de novo coronary lesions was performed. The lesion lumen area and three IVUS-derived stenosis indixes comparing lesion lumen area with the lesion external elastic lamina (EEL) area, the mean reference lumen area and the mean reference EEL area were compared with the results of stress myocardial perfusion imaging.
  
  
  RESULTS
  The lesion lumen area and three IVUS-derived stenosis indexes showed sensitivities and specificities ranging between 80% and 90% using stress myocardial perfusion imaging as the gold standard. The lesion lumen area < or =4 mm2 is a simple and highly accurate criterion for significant coronary narrowing.
  
  
  CONCLUSIONS
  Quantitative IVUS indices can be reliably used for identifying significant epicardial coronary artery stenoses.
authors.affiliation: Division of Cardiology, Self-Defense Forces Central Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishioka
authors.forename: A M
authors.initials: AM
authors.lastname: Amanullah
authors.forename: H
authors.initials: H
authors.lastname: Luo
authors.forename: H
authors.initials: H
authors.lastname: Berglund
authors.forename: C J
authors.initials: CJ
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Nagai
authors.forename: N
authors.initials: N
authors.lastname: Hakamata
authors.forename: S
authors.initials: S
authors.lastname: Katsushika
authors.forename: A
authors.initials: A
authors.lastname: Uehata
authors.forename: B
authors.initials: B
authors.lastname: Takase
authors.forename: K
authors.initials: K
authors.lastname: Isojima
authors.forename: D S
authors.initials: DS
authors.lastname: Berman
authors.forename: R J
authors.initials: RJ
authors.lastname: Siegel
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D010477:Perfusion; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018084:Ultrasonography, Interventional