IgG antibodies to Lewis type 2 antigens in serum of H. pylori-infected and noninfected blood donors of different Lewis(a,b) blood-group phenotype.
Individuals of the Le(b+)/secretor phenotype revealed a stronger natural immune response to Le(x) and Le(y) epitopes irrespective of Helicobacter pylori serologic status. In contrast, H. pylori-infected Le(b-) type individuals showed a significantly higher proportion of strong responders to Le(x) antigen compared with the H. pylori-uninfected subgroup. The data suggest that the immune response to Lewis type 2 determinants is related to both the H. pylori serologic status and the Le(a,b) phenotype of the host.
Kurtenkov
O
O
Institute of Experimental and Clinical Medicine, Tallinn, Estonia.
Klaamas
K
K
Miljukhina
L
L
Shljapnikova
L
L
Ellamaa
M
M
Bovin
N
N
Wadström
T
T
D000328:Adult; D000368:Aged; D001782:Blood Donors; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007983:Lewis Blood Group Antigens