title: Isolation and characterization of new limonoid glycosides from Citrus unshiu peels.
abstract: Three limonoid glycosides were isolated from Citrus unshiu peels, and their structures were determined based on MS and NMR spectroscopic data as nomilinic acid 17-O-beta-D-glucopyranoside (1), methyl nomilinate 17-O-beta-D-glucopyranoside (2), and obacunone 17-O-beta-D-glucopyranoside (3). In particular, the location of the sugar moiety was clearly determined by the B/E constant linked scan FABMS method. No limonoid glycosides obtained here were found to have antitumor activity in NCI-H292 and EL-4 cell lines.
authors.affiliation: Institute for Comprehensive Agricultural Sciences, Kinki University, Nara, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sawabe
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Kiso
authors.forename: H
authors.initials: H
authors.lastname: Kishine
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsubo
authors.forename: T
authors.initials: T
authors.lastname: Minematsu
authors.forename: Y
authors.initials: Y
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002957:Citrus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008969:Molecular Sequence Data; D014407:Tumor Cells, Cultured
chemical_list: D006027:Glycosides