title: [Non-glucose carbohydrates in the parenteral nutrition of patients with systemic inflammatory response syndrome].
abstract: OBJECTIVE
  To compare tolerance of two sources of isocaloric intake (fructose-glucose-xylitol mixture [FGX] versus glucose) in parenteral nutrition for patients with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  Open, prospective, cohort and randomized study.
  
  
  METHODS
  Intensive Care Unit.
  
  
  METHODS
  Two groups of patients admitted in ICU: acute pneumonia with sepsis, and necro-hemorrhagic pancreatitis. Criteria of exclusion were: diabetes, previous hypertriglyceridemia, renal failure with serum creatinine > 3 mg/dL on admission in ICU, or hyperbilirrubinemia > 2.5 mg/dL. Parenteral nutrition (TPN), consisting of 1.4 g AA + Lipids 1.3 g + carbohydrates 4 g/kg/d, (either glucose or FGX at random) was administered. Basal levels and days 1st, 4th and 10th plasma glucose, triglycerides, cholesterol, uric acid were determined, and blood venous gases as well. Capillary glycemia was measured every 6 hours and insulin given if glucose levels rose above 180 mg/dL.
  
  
  METHODS
  Fisher's exact test; Student t-test; Mann-Whitney test. Data as mean and SD.
  
  
  CONCLUSIONS
  During 48 months, 119 patients admitted in the ICU (72 with pneumonia and 47 with pancreatitis) were included. In pneumonia, tolerance was similar with both intakes; glycemia was kept at the same level in both, but the amount of insulin given was significantly more in those patients fed on glucose (p < 0.05). Nevertheless, resting blood glucose and triglyceride levels were higher in pancreatitic patients, and more insulin was required. Those on FGX had lower triglyceride plasma levels (p < 0.05) and less insulin was given throughout the study. Glycemia was kept lower though no statistical significance was reached (p < 0.1). No hyperuricemia nor lactic acidosis was found.
authors.affiliation: Cuidados Intensivos, Hospital Severo Ochoa Leganés, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: López Martínez
authors.forename: M
authors.initials: M
authors.lastname: Sánchez Castilla
authors.forename: P
authors.initials: P
authors.lastname: de Juana Velasco
authors.forename: R
authors.initials: R
authors.lastname: Díaz Abad
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez Roldán
authors.forename: A
authors.initials: A
authors.lastname: García de Lorenzo y Mateos
authors.forename: F
authors.initials: F
authors.lastname: Del Nogal Sáez
mesh_terms: D002241:Carbohydrates / Q000008:administration & dosage*; D015331:Cohort Studies; D006801:Humans; D019283:Pancreatitis, Acute Necrotizing / Q000628:therapy*; D010288:Parenteral Nutrition / Q000379:methods*; D018410:Pneumonia, Bacterial / Q000628:therapy*; D011446:Prospective Studies; D018805:Sepsis; D018746:Systemic Inflammatory Response Syndrome / Q000628:therapy*
chemical_list: D002241:Carbohydrates
vernacular_title: Hidratos de carbono no-glucosa en la nutrición parenteral de pacientes con síndrome de respuesta inflamatoria sistémica.