Antihyperlipidemic action of Ogi-Keishi-Gomotsu-To-Ka-Kojin against cyclophosphamide-induced hyperlipidemia in rabbits.
The effect of Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK), a Japanese traditional herbal medicine (Kampo medicine), has been studied in a cyclophosphamide (CPM)-induced hyperlipidemia model in fasted rabbits. In this model, the accumulation of chylomicrons and very low density lipoprotein (VLDL) was known to occur as a result of a reduction in lipoprotein lipase (LPL) activity in the heart and heparin-releasable heart LPL. Oral administration of OKGK for 4 weeks was found to reverse the increase in serum triglycerides and cholesterol produced by CPM treatment especially in chyromicrons and VLDL. In addition, OKGK treatment led to a recovery in postheparin plasma LPL activity and heparin-releasable heart LPL activity which were reduced markedly by CPM treatment. We previously reported that OKGK increased LPL activity in postheparin plasma in rats. In this study, we have also found that OKGK improved hyperlipidemia in the CPM-induced hyperlipidemia model in rabbits, mainly due to an increase in heparin-releasable heart LPL activity and postheparin plasma LPL activity.
Inoue
M
M
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya Japan.
Wu
C Z
CZ
Ogihara
Y
Y
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004789:Enzyme Activation; D006321:Heart / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000188:drug therapy; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000139:chemically induced / Q000188:drug therapy; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology; D008517:Phytotherapy; D011817:Rabbits
D000924:Anticholesteremic Agents; D004365:Drugs, Chinese Herbal; D007328:Insulin; C117786:ogi-keishi-gomotsu-to-ka-kojin; D003520:Cyclophosphamide; D006493:Heparin; D008071:Lipoprotein Lipase