title: Peripheral vascular resistance limits exercise functional capacity of mild hypertensives.
abstract: To evaluate the physiological basis for suboptimal peak exercise oxygen consumption (VO2p) observed in the early stage of hypertension, 25 WHO Stage I hypertensive men with normal left ventricular mass and 10 healthy control subjects of equivalent age underwent the maximal cardiopulmonary exercise test with contemporary measurement of cardiac output with Tc99m angiocardiography. At peak exercise hypertensive patients had lower VO2p (p < 0.045) and cardiac output (p < 0.014) and higher vascular resistance (p < 0.010) than controls. At multiple regression analysis VO2 was positively related to cardiac output in controls (r = 0.80, p < 0.02), whereas in hypertensives the best (negative) correlation was observed with peripheral vascular resistance (r = -0.72, p < 0.04). Thus reduced cardiopulmonary function during physical exercise in hypertensives seems to be mainly related to impaired peripheral vascular autoregulation.
authors.affiliation: Clinica Medica I, University of Florence, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Modesti
authors.forename: G
authors.initials: G
authors.lastname: Olivo
authors.forename: F
authors.initials: F
authors.lastname: Pestelli
authors.forename: F
authors.initials: F
authors.lastname: Rocchi
authors.forename: S
authors.initials: S
authors.lastname: Vanni
authors.forename: R C
authors.initials: RC
authors.lastname: Tedeschini
authors.forename: I
authors.initials: I
authors.lastname: Cecioni
authors.forename: G F
authors.initials: GF
authors.lastname: Gensini
mesh_terms: D000328:Adult; D000368:Aged; D015308:Anaerobic Threshold / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D002302:Cardiac Output / Q000502:physiology; D004452:Echocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010101:Oxygen Consumption / Q000502:physiology; D015635:Radionuclide Ventriculography; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D013667:Technetium; D014655:Vascular Resistance / Q000502:physiology*
chemical_list: D019275:Radiopharmaceuticals; D002245:Carbon Dioxide; D013667:Technetium