Absence of interaction between tiagabine, a new antiepileptic drug, and the benzodiazepine triazolam.
In a randomised, double blind, placebo-controlled, four-period cross-over study in 12 healthy volunteers, the potential pharmacodynamic and pharmacokinetic interactions between the new antiepileptic drug, tiagabine, and the benzodiazepine, triazolam, were investigated. A single dose of tiagabine HCl 10 mg did not enhance the sedative or cognitive effects of a single dose of the benzodiazepine triazolam 0.125 mg, although the time-course of the effects was prolonged. Furthermore, tiagabine did not produce any statistically significant effects on the pharmacokinetics of triazolam. Similarly, the pharmacokinetics of tiagabine were not modified by triazolam. Tiagabine was well tolerated when administered alone or with triazolam.
Richens
A
A
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, UK.
Marshall
R W
RW
Dirach
J
J
Jansen
J A
JA
Snel
S
S
Pedersen
P C
PC
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D003071:Cognition / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D018757:GABA Modulators / Q000493:pharmacokinetics; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000493:pharmacokinetics*; D009557:Nipecotic Acids / Q000493:pharmacokinetics*; D012438:Saccades / Q000187:drug effects; D000078308:Tiagabine; D014229:Triazolam / Q000494:pharmacology*
D000927:Anticonvulsants; D018757:GABA Modulators; D006993:Hypnotics and Sedatives; D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D014229:Triazolam; D000078308:Tiagabine