title: Hypofractionated radiation therapy for invasive thyroid carcinoma in dogs: a retrospective analysis of survival.
abstract: Thirteen dogs with invasive thyroid carcinoma (WHO classification T2b or T3b) seen between January 1991 and October 1997 were treated by external beam irradiation. Four once-weekly fractions of 9 gray of 4 MeV X-rays were administered. Four of the dogs died of progression of the primary disease and four from metastatic spread. Of the remaining dogs, three died of unrelated problems, although two were still alive at the time of the censor. Kaplan-Meier analysis of the survival time from first dose to death from either primary or metastatic disease gave a median survival time of 96 weeks (mean 85 weeks, range six to 247 weeks). Radiographic evidence of pulmonary metastatic disease at presentation had no prognostic value whereas crude growth rate was a highly significant factor. The present series indicates that radiation therapy should be considered an important modality for the control of invasive thyroid carcinoma in the dog.
authors.affiliation: Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk.
authors.forename: M J
authors.initials: MJ
authors.lastname: Brearley
authors.forename: A M
authors.initials: AM
authors.lastname: Hayes
authors.forename: S
authors.initials: S
authors.lastname: Murphy
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000145:classification / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D004283:Dog Diseases / Q000145:classification / Q000401:mortality / Q000532:radiotherapy*; D004285:Dogs; D019583:Dose Fractionation, Radiation; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D008297:Male; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000145:classification / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*