title: Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.
abstract: 1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Rotzinger
authors.forename: M
authors.initials: M
authors.lastname: Bourin
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: R T
authors.initials: RT
authors.lastname: Coutts
authors.forename: G B
authors.initials: GB
authors.lastname: Baker
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D018687:Antidepressive Agents, Second-Generation / Q000378:metabolism* / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D004347:Drug Interactions / Q000502:physiology; D006801:Humans
chemical_list: D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation