Disorders of proprioceptive responses in monkeys after cerebellar lesions: an analysis using the Denny-Brown Collection.
We used the Denny-Brown Research Collection to study in detail the reflex responses of monkeys after ablation of the anterior lobe, posterior lobe or the entire cerebellum. The Collection includes written, film and histological records, and photographs of the brain at autopsy. Large cerebellar ablations severely suppress proprioceptive responses, thereby significantly impairing the capacity to stand, walk, and hop. Cutaneous reflexes are also impaired, although more selectively, permitting expression of normally suppressed responses such as magnet reactions and tactile avoiding responses. Enhancement (release) of responses to truncal cutaneous stimulation, along with suppression of opposing proprioceptive responses, leads to postures of persistent flexion. Large cerebellar lesions also interfere with reflex responses mediated by visual and vestibular systems. More limited cerebellar ablations have similar, but less severe effects.
Vilensky
J A
JA
Department of Anatomy, Indiana University School of Medicine, Fort Wayne 46805, USA. vilensk@ipfw.edu
Barnhart
S W
SW
Gilman
S
S
Cook
J A
JA
Morecraft
R J
RJ
D000818:Animals; D001362:Avoidance Learning; D001931:Brain Mapping / Q000379:methods; D002531:Cerebellum / Q000033:anatomy & histology / Q000502:physiology*; D018737:Hand Strength; D000882:Haplorhini; D008124:Locomotion; D009043:Motor Activity; D011434:Proprioception / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012026:Reflex, Stretch; D012867:Skin / Q000294:innervation; D014110:Touch