title: Androstenedione effects on the vasopressin innervation of the rat brain.
abstract: The steroid hormone androstenedione profoundly influences the development and expression of sexual and aggressive behavior. The neural basis of these effects are, however, poorly understood. In this study we evaluated androstenedione's ability to maintain vasopressin peptide levels in the gonadal steroid-responsive vasopressin cells of the bed nucleus of the stria terminalis and the centromedial amygdala, and their projections. Adult male rats were castrated and given testosterone, androstenedione or no hormonal treatment for five weeks. Their brains were then processed for vasopressin immunoreactivity. Androstenedione and testosterone treatment were equally effective in preventing the reduction of vasopressin immunoreactivity associated with castration. Androstenedione may therefore be able to mimic the effects of testosterone on testosterone-responsive neural systems.
authors.affiliation: Center for Neuroendocrine Studies, Neuroscience and Behavior Program & Department of Psychology, University of Massachusetts, Amherst 01003-7720, USA.
authors.forename: C
authors.initials: C
authors.lastname: Villalba
authors.forename: C J
authors.initials: CJ
authors.lastname: Auger
authors.forename: G J
authors.initials: GJ
authors.lastname: De Vries
mesh_terms: D000679:Amygdala / Q000378:metabolism; D000735:Androstenedione / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D009919:Orchiectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000494:pharmacology; D013788:Thalamus / Q000378:metabolism
chemical_list: D001127:Arginine Vasopressin; D013739:Testosterone; D000735:Androstenedione