[Pathophysiologic aspects of S-100beta protein: a new biological marker of brain pathology].
S-100 protein is an acidic calcium-binding protein with a molecular weight of 21 kDa consisting of two submits alpha and beta, which are combined to give alphaalpha (S-100a), alphabeta (S-100a) and betabeta (S-100b) dimeric forms. S-100 protein is much more abundant in the brain than in other tissus and is present as a mixture of S-100a and S-100b (named S-100beta). These two isoforms are predominantly synthesized and secreted by glial cells. Structural damage of these cells causes leakage of S-100beta protein into the extracellular compartment and into cerebrospinal fluid, further entering the bloodstream. We provide here an overview of the physicochemical properties of S-100beta protein, of its pathological aspects and of possible interest in measuring this protein in biological fluids during cerebral diseases and brain damage occurring after surgical events.
Beaudeux
J
J
Laboratoire de biochimie C, Hôpital La Pitié, 83, boulevard de l'Hôpital, 75013 Paris.
Dequen
L
L
Foglietti
M
M
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002135:Calcium-Binding Proteins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D019281:Dimerization; D006801:Humans; D046911:Macromolecular Substances; D009414:Nerve Growth Factors; D020033:Protein Isoforms / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis* / Q000737:chemistry / Q000235:genetics
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D046911:Macromolecular Substances; D009414:Nerve Growth Factors; D020033:Protein Isoforms; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
La protéine S-100beta: un nouveau marqueur biologique de pathologie cérébrale.