title: [Endothelial cell precursors in the avian embryo].
abstract: Whereas the origin and migration of endothelial cells (ECs) have been studied primarily in the avian embryo, the molecular mechanisms governing these events in birds and mammals were unraveled following the identification of specific growth factors and of their receptors. In particular, analytic and experimental studies of vascular endothelial growth factor (VEGF) and its receptors have provided significant insights into the developmental biology of the vascular system. VEGFR2 is the earliest marker expressed by EC precursors in chickens and mice. Based on the localization of VEGFR2-positive cells in the avian embryo and on findings from clonal culture experiments, two types of EC precursors can be differentiated as early as the gastrulation stage, namely posterior mesoderm hemangioblasts capable of differentiating into both ECs and hematopoietic cells and anterior angioblasts capable of yielding only ECs.
authors.affiliation: Institut d'Embryologie Cellulaire et Moléculaire du CNRS et du Collège de France, Nogent-sur-Marne, France.
authors.forename: A
authors.initials: A
authors.lastname: Eichmann
authors.forename: C
authors.initials: C
authors.lastname: Corbel
mesh_terms: D000818:Animals; D001717:Birds / Q000196:embryology*; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000196:embryology*; D008222:Lymphokines / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor; D013234:Stem Cells / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor
vernacular_title: Les précurseurs des cellules endothéliales chez l'embryon d'oiseau.