EPR dose reconstruction for bone-seeking 90Sr.
The results of the EPR dose reconstruction in calcified tissues of dog injected with 90Sr are presented. It has been established that there is no essential difference in the values of doses absorbed in tooth tissues of teeth in symmetric positions in the mouth, whereas a significant difference occurs in the values of absorbed doses in teeth in non-symmetric positions. In the case of 90Sr internal exposure the dose reconstruction in crown dentine plays an important role. It has been found that its quantity is close to the dose in diaphyseal cortical bone of the femur, dose at the endosteal bone surface and in femural fatty marrow. The fact that these values exceed doses absorbed in tooth enamel points out the predominant contribution of internal exposure. The highest absorbed doses have been observed in metaphyseal trabecular femur bones, tooth alveolar bone walls, and cortical and trabecular vertebra that can be considered as suitable candidates for biomarkers of internal 90Sr exposure for post-mortal autopsy. The satisfactory correlation has been found between the doses reconstructed in calcified dog tissues and the doses measured by EPR in alanine dosimeters fixed in (or nearby) the sites of autopsy of bones/teeth. The experiments provide support for the view that EPR retrospective dosimetry with calcified tissues for internal exposure is unique in providing useful information on the doses obtained.
Ignatiev
E A
EA
Institute of Metal Physics, Russian Academy of Sciences, Ekaterinburg, Russia.
Lyubashevskii
N M
NM
Shishkina
E A
EA
Romanyukha
A A
AA
D000042:Absorption; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002138:Calibration; D004285:Dogs; D004578:Electron Spin Resonance Spectroscopy; D005269:Femur / Q000378:metabolism; D007568:Jaw / Q000378:metabolism; D011829:Radiation Dosage; D011874:Radiometry; D013326:Strontium Radioisotopes / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014070:Tooth / Q000378:metabolism*
D013326:Strontium Radioisotopes