title: Nucleotide sequence of equine caspase-1 cDNA.
abstract: Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. We report the cloning and sequencing of equine caspase-1 cDNA. Equine caspase-1 is 405 amino acids in length and has 72% and 63% identity to human and mouse caspase-1, respectively, at the amino acid level. Sites of proteolytic cleavage and catalytic activity as identified in human caspase-1, are conserved.
authors.affiliation: Department of Veterinary Pathology, University of Glasgow Veterinary School, UK.
authors.forename: S
authors.initials: S
authors.lastname: Wardlow
authors.forename: M N
authors.initials: MN
authors.lastname: Penha-Goncalves
authors.forename: D J
authors.initials: DJ
authors.lastname: Argyle
authors.forename: D E
authors.initials: DE
authors.lastname: Onions
authors.forename: L
authors.initials: L
authors.lastname: Nicolson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D020170:Caspase 1 / Q000235:genetics*; D018076:DNA, Complementary; D018397:Equidae; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data
chemical_list: D018076:DNA, Complementary; D020170:Caspase 1