Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer.
This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified.
Silva
J M
JM
Department of Medical Oncology, Clinica Puerta de Hierro, Madrid, Spain.
Garcia
J M
JM
Gonzalez
R
R
Dominguez
G
G
Jareño
E
E
Palacios
J
J
Navarro
F
F
Provencia
M
M
España
P
P
Bonilla
F
F
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005838:Genotype; D006801:Humans; D019656:Loss of Heterozygosity