title: MR perfusion imaging in human brain using the UNFAIR technique. Un-inverted flow-sensitive alternating inversion recovery.
abstract: Pulsed arterial spin labeling magnetic resonance techniques have been developed recently to estimate cerebral blood flow (CBF). Flow-sensitive alternating inversion recovery (FAIR) is one such technique that has been implemented successfully in humans. Un-inverted FAIR (UNFAIR) is an alternative technique in which the flow-sensitive image is acquired following inversion of all spins outside the slice of interest, and the control image is acquired without any spin labeling. This approach is potentially more efficient than FAIR since the UNFAIR control image is entirely flow independent and need only be acquired once. Here, we describe implementation of the sequence on a clinical 1.5 T magnetic resonance system. Both FAIR and UNFAIR perfusion-weighted images were obtained from six normal volunteers. Wash-in/wash-out curves measured in cortical gray and white matter were practically identical for the two techniques, as predicted by our model.
authors.affiliation: Center for Advanced Brain Imaging, The Nathan S. Kline Institute, Orangeburg, New York 10962, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Yongbi
authors.forename: C
authors.initials: C
authors.lastname: Branch
authors.forename: J
authors.initials: J
authors.lastname: Hrabe
authors.forename: G
authors.initials: G
authors.lastname: Johnson
authors.forename: J A
authors.initials: JA
authors.lastname: Helpern
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male