[Numerical change of 7, 17 and Y chromosomes in human lung carcinoma detected by fluorescence in situ hybridization].
OBJECTIVE
To study the copy number of chromsomes 7,17 and Y in lung carcinomas.


METHODS
Fluorescence in situ hybridization (FISH) was used to detect the number of above mentioned chromosomes on the touch smears of 17 cases of lung carcinoma (adenocarcinoma and squamous cell carcinoma).


RESULTS
Triploid chromosome 7 FISH signals were found in 31.73% of the tumor nuclei, dipoid chromosome 17 FISH signals in 43.00% and monoploid chromosome Y FISH signals in 58.04% of these nuclei.


CONCLUSIONS
The number of chromosome 7 was obviously increased in both lung adenocarcinoma and squamous cell carcinoma, and the rate of trisomy 7 was the highest. In addition, there is a significant difference in the distribution of chromosome 7 ploidy between lung adenocarcinoma and squamous cell carcinoma.
Zhang
J
J
Department of Pathology, General Hospital of PLA, Beijing.
Chen
L
L
Lü
Y
Y
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014998:Y Chromosome