title: Co-amoxiclav affects cytokine production by human polymorphonuclear cells.
abstract: Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1beta, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.
authors.affiliation: Biomedical Science and Human Oncology, University of Turin, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Reato
authors.forename: A M
authors.initials: AM
authors.lastname: Cuffini
authors.forename: V
authors.initials: V
authors.lastname: Tullio
authors.forename: A I
authors.initials: AI
authors.lastname: Palarchio
authors.forename: A
authors.initials: A
authors.lastname: Bonino
authors.forename: R
authors.initials: R
authors.lastname: Foa
authors.forename: N A
authors.initials: NA
authors.lastname: Carlone
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D016209:Interleukin-8 / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism* / Q000382:microbiology; D014409:Tumor Necrosis Factor-alpha / Q000187:drug effects / Q000235:genetics
chemical_list: D016207:Cytokines; D004791:Enzyme Inhibitors; D007375:Interleukin-1; D016209:Interleukin-8; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D019980:Amoxicillin-Potassium Clavulanate Combination