title: Head and neck cancers associated with Madelung's disease.
abstract: BACKGROUND
  Madelung's disease is a rare lipodystrophy that presents with multiple fatty masses in the neck, trunk, and upper extremities. The fatty accumulation is considered a benign disease, but compression of the aerodigestive tract may occur in long-standing disease.
  
  
  METHODS
  Eight Chinese patients with Madelung's disease were reviewed. All were male, aged 48 to 67 years, with a history of disease ranging from 4 to 20 years. Two of the eight patients developed aerodigestive symptoms and were subsequently found to have head and neck cancers. These two patients are described.
  
  
  RESULTS
  The possible mechanism that may account for an increase in malignant tumors of the airway in this group of patients is the synergistic effect of smoking and alcohol abuse as risk factors for both Madelung's disease and malignant tumors of the airway. Currently it is recommended that these patients should have their fatty lesions removed surgically. The removal of fat facilitates examination of the neck for signs of cervical lymphadenopathy in malignant disease.
  
  
  CONCLUSIONS
  Patients with Madelung's disease should be followed regularly. The development of aerodigestive symptoms should be fully investigated with endoscopy and imaging. The cause of symptoms should not be attributed to fatty compression until a carcinoma of the upper airway has been excluded.
authors.affiliation: Department of Surgery, The Chinese University of Hong Kong, Shatin.
authors.forename: E S
authors.initials: ES
authors.lastname: Chan
authors.forename: A T
authors.initials: AT
authors.lastname: Ahuja
authors.forename: A D
authors.initials: AD
authors.lastname: King
authors.forename: W Y
authors.initials: WY
authors.lastname: Lau
mesh_terms: D000437:Alcoholism / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000150:complications; D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D007013:Hypopharynx; D008069:Lipomatosis, Multiple Symmetrical / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000150:complications; D012907:Smoking / Q000009:adverse effects