Experimental model of renovascular hypertension.
OBJECTIVE
To establish a model of renovascular hypertension.


METHODS
A 4/0 resorbable chromic catgut ligature was used to ligate subtotally the renal arteries of 18 dogs, forming experimental renovascular hypertension steadily. Blood pressure, plasma renin activity, the ultrastructural changes of juxtaglomerular apparatus and renal artery wall were studied after the constriction.


RESULTS
It was reasonable that renal blood flow measured with an electromagnetic flowmeter was reduced by 30% after the constriction. The pathological changes of the induced renal artery stenosis were similar to those of fibromuscular dysphasia.


CONCLUSIONS
The findings provide valuable evidence for the treatment of renovascular hypertension.
Cao
X
X
Department of Radiology, Tianjin Medical University Hospital, China.
He
N
N
Wu
E
E
Bai
J
J
Yang
H
H
Chang
J
J
D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D004285:Dogs; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007606:Juxtaglomerular Apparatus / Q000648:ultrastructure; D012083:Renin / Q000097:blood
D012083:Renin