[Relationship between p16 and Rb protein expression in astrocytomas].
OBJECTIVE
p16 and Rb protein were examined in primary astrocytomas in order to study the correlation between p16 and Rb proteins.


METHODS
p16 and Rb pretoin were immunostained by SP immunohistochemical method in the sections of formalin fixed paraffin embedded tumor tissue from 102 patients with astrocytoma brain tumors.


RESULTS
p16 and Rb protein were expressed in all low grade (WHO Grade I and II) astrocytomas but only in 48.1% and 57.4% astrocytomas of Grade III and Grade IV respectively, in which, 24/31 of Rb protein positive tumors showed null or low expression of p16 protein, while 19/23 of Rb negative tumors were associated with positive or high level expression of p16 protein.


CONCLUSIONS
(a) p16 and Rb proteins were both involved in astrocytoma progression. (b) Negatively correlated pressionof p16 and Rb protein might be one of characteristics of malignant astrocytoma.
Lin
Y
Y
Department of Neurosurgery of Teaching Hospitol, Nantong Medical College.
Huang
C
C
Liu
D
D
D001254:Astrocytoma / Q000235:genetics / Q000378:metabolism*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D015870:Gene Expression; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016160:Retinoblastoma Protein / Q000096:biosynthesis*
D019941:Cyclin-Dependent Kinase Inhibitor p16; D016160:Retinoblastoma Protein