title: Determination of factors responsible for the declining incidence of colorectal cancer.
abstract: BACKGROUND
  After rising for 13 years in the United States, the incidence of colorectal cancer began to fall in 1986 and has continued to drop since then. This report contains an analysis of the pattern of declining colorectal cancer risk by colorectal subsite, race, and gender and a time trend investigation of suspected risk modifiers of colorectal cancer.
  
  
  METHODS
  Colorectal cancer incidence data were obtained from the Surveillance, Epidemiology, and End Results Public Use Files from 1973 to 1994. The following exposure variables were assessed, focussing principally on the period 1970 to 1980: dietary fat, fiber, ethanolic beverages, vitamin A, vitamin C, iron, calcium, estrogen, aspirin, energy intake, body mass index, serum cholesterol, body iron stores, cholecystectomy, constipation, cigarette use, physical activity, and colonoscopic polypectomy. Data sources used in these analyses were principally National Health and Nutrition Examination Surveys I, II, and III.
  
  
  RESULTS
  After 1985 colorectal cancer incidence declined predominantly in the distal colorectum almost equally in both white males and white females. Some exposures remained unchanged or trended in the wrong direction (dietary fat, calcium, ethanol, energy intake, physical activity, overweight prevalence, and cholecystectomy). Others did not apply equally to both genders (estrogen, aspirin, ethanol, calcium, and cholecystectomy). Others may become significant in the future, such as aspirin, estrogen, or calcium, because their supplementation is now prevalent, but were not in 1970 to 1975. Of all the risk factors or interventions assessed, the one most consistent with the observed pattern of change is increased use of colonoscopic polypectomy.
  
  
  CONCLUSIONS
  The best method to diminish the incidence of colorectal cancer today may be to increase the use of screening colonoscopy and polypectomy.
authors.affiliation: Department of Surgery, College of Medicine, School of Public Health, University of Illinois at Chicago, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Nelson
authors.forename: V
authors.initials: V
authors.lastname: Persky
authors.forename: M
authors.initials: M
authors.lastname: Turyk
mesh_terms: D015179:Colorectal Neoplasms / Q000453:epidemiology*; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009749:Nutrition Surveys; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology