Radiotherapy for the treatment of metastatic granulosa cell tumor in the mediastinum: a case report.
OBJECTIVE
We report a case of metastatic ovarian granulosa cell tumor in the mediastinum with a 2-year disease-free interval after treatment with radiotherapy and review the literature regarding the use of radiotherapy in recurrent and metastatic granulosa cell tumor.


METHODS
The patient's medical records, histological slides, and radiological films were reviewed. The pertinent references were obtained using a Medline search and cross-references.


RESULTS
A patient with Stage 1A granulosa cell tumor developed a recurrence in the retroperitoneum 10 years after initial surgery. She was treated with chemotherapy followed by surgical resection. She subsequently developed metastatic tumor in the mediastinum which responded completely to radiotherapy. She has remained disease free for 2 years since the completion of radiotherapy.


CONCLUSIONS
Radiotherapy is a treatment option that should be considered in localized recurrent or metastatic granulosa cell tumor that is not amenable to surgery as it can potentially control the disease for several years.
Lee
I W
IW
Department of Gynecologic Oncology & Urogynecology, KK Women's & Children's Hospital, Singapore.
Levin
W
W
Chapman
W
W
Goldberg
R E
RE
Murphy
K J
KJ
Milosevic
M
M
D000328:Adult; D005260:Female; D006106:Granulosa Cell Tumor / Q000532:radiotherapy*; D006801:Humans; D008479:Mediastinal Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D010051:Ovarian Neoplasms / Q000532:radiotherapy*