[Expression of p53 in nephroblastoma and neuroblastoma].
We studed on the expression of p53 in 48 nephroblastomas and 32 neuroblastomas wit, immunohistochemical method of avidinbiotinperoxidase complex. 11 of the nephroblastomas were positive and all neuroblastomas were negative. Statistical analysis revealed that abnormal expression of p53 was significantly correlated with NWTS--II classification, NWTS--III clinical pathology stages and metastasis of nephroblastoma. The results indicate that abnormal expression of p53 is not only involved in the development, but also in the differentiation and metastasis of nephroblastoma. Therefore, detection of p53 expression may have significant clinical importance in the evaluation of prognosis of nephroblastoma. However, the absence of expression of p53 in neuroblastomas suggests that the inactivation of this gene does not play a significant role in the tumor's occurring and progression.
Bu
X
X
Department of Surgery, Pediatric Hospital, Shanghai Medical University.
Shen
Z
Z
Jin
B
B
D002648:Child; D016158:Genes, p53; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009154:Mutation; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D009396:Wilms Tumor / Q000235:genetics / Q000378:metabolism* / Q000556:secondary
D016159:Tumor Suppressor Protein p53