title: Living donor liver transplantation in critically ill children.
abstract: From December 1993, St Christopher's Hospital for Children, Philadelphia, PA, USA has provided living donors the opportunity to donate a portion of their liver to children who are critically ill. This report evaluates the results of living donor liver transplants (LDLT) in critically ill children. We retrospectively reviewed the first 22 LDLT at our institution and compared the patient and graft survival of the nine critically ill children with the 13 stable children. Twenty-two LDLT have been performed at our institution between December 1993 and October 1997. Nine of 22 transplants [United Network for Organ Sharing (UNOS) Status I] were performed in children who were critically ill. Thirteen of the LDLT (UNOS Status II and III) were performed on stable children either in the hospital or admitted electively from home. The median weight and age at the time of transplant were 7 kg (range 4.6-54.5 kg) and 16 months (range 3 months-12 yr), respectively, and there was no statistical difference between the two groups. In critically ill children the 1-yr allograft and patient survival was 66% and 89%, respectively, exceeding the published results from UNOS for patients on life support (59.5% graft and 69.7% patient survival at 1 yr). One-yr allograft and patient survival in the stable children was 92.3% and 100%, respectively. All living donors are alive and well with normal liver function. In conclusion, our results show that LDLT is a viable approach for transplantation in critically ill children with liver failure and should be offered to potential donors.
authors.affiliation: St Christopher's Hospital for Children, Department of Surgery, Philadelphia, PA 19134-1095, USA.
authors.forename: A
authors.initials: A
authors.lastname: Casas
authors.forename: K
authors.initials: K
authors.lastname: Falkenstein
authors.forename: M
authors.initials: M
authors.lastname: Gallagher
authors.forename: S P
authors.initials: SP
authors.lastname: Dunn
mesh_terms: D001656:Biliary Atresia / Q000601:surgery*; D002648:Child; D016638:Critical Illness; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D017114:Liver Failure, Acute / Q000503:physiopathology / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D019520:Living Donors; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous