[Development and evaluation of parent-related quality of life questionnaires for asthmatic children and their parents or caregivers--evaluation of treatment process with sustained-release theophylline dry syrup].
A quality of life (QOL) questionnaire for asthmatic children and their parents or caregivers was shown to exhibit reliability, factorial validity and possibility for application study in our previous report. The aim of this study was to examine longitudinal study of the questionnaires, including changes of QOL, responsibility to asthmatic symptoms, consistency with conventional asthma scores and clinical outcomes during treatment with theophylline dry syrup for about three months. Overall QOL scores increased significantly (p < 0.01) with improvement in clinical outcomes. Longitudinal changes of QOL were compared with differences (after-before) and changes of ratio [(after-before/before)] in QOL by correlation analysis between differences of asthma scores. Changes of ratio in QOL were reflected by the clinical outcomes. Results of investigation of correlation between differences in asthma scores and changes of ratio in QOL domains were considered as follows. Physical domain was correlated with asthma symptoms, given the moderate correlation (rho = 0.497). Social and family domains showed fair correlation (rho = 0.382 - 0.384 respectively), both domains were hard to correlate with differences in asthma scores. Emotional domain showed fair correlation (rho = 0.264) for reflecting family's emotion. Poor correlation (rho = 0.071) was observed in individual growth domain which was necessary to evaluate for longer term. Changes of ratio in QOL responded significantly (p < 0.01) to improved and worst-unchanged groups which were categorized by the differences in asthma scores. In conclusion, QOL questionnaires showed longitudinal validity for clinical outcomes and responsibility to asthmatic symptoms. It yields useful information for understanding how asthmatic symptoms affect parents or caregivers and investigating what treatments should be prescribed for the patients with asthma.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine.
Fukao
T
T
Hirayama
K
K
Sakamoto
T
T
Torii
S
S
D000284:Administration, Oral; D001249:Asthma / Q000188:drug therapy*; D017028:Caregivers; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013806:Theophylline / Q000008:administration & dosage*
D013806:Theophylline