Involvement of 5-HT3 receptors in the prolactin release induced by immobilization stress in rats.
1. Central serotoninergic participation in prolactin (PRL) secretion regulation is a well-established event. Furthermore, 5-HT may participate in the mediation of stress-induced PRL release. 2. The authors investigated the effect of the blockade of 5-HT3 receptors on the PRL release induced by immobilization stress in male rats. 3. Pretreatment with the 5-HT3 receptor antagonist, ondansetron (0.10-1.0 mg/kg i.p.), inhibited about 50% of the PRL response to immobilization stress. A lower dose of ondansetron (0.05 mg/kg i.p.) had no effect on the PRL response. No dose-response inhibition was observed. 4. It is concluded that serotoninergic activation related to the mediation of the stress-induced PRL response involves the 5-HT3 receptors.
Nonaka
K O
KO
Department of Physiological Sciences, Federal University of São Carlos, SP, Brazil.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007103:Immobilization; D008297:Male; D017294:Ondansetron / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013315:Stress, Psychological
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017294:Ondansetron; D011388:Prolactin