Axon guidance: starting and stopping with slit.
As developing axons navigate, they exhibit various behaviours: extending and branching, pausing, changing direction, retracting. Now, the Slit protein has been discovered to have striking positive and negative effects on axon growth and guidance.
Guthrie
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Department of Developmental Neurobiology, Hodgkin Building King's College, Guy's Campus, London, SE1 9RT, UK.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002455:Cell Division; D002490:Central Nervous System / Q000254:growth & development; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins; D017344:Genes, Insect; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008959:Models, Neurological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology; D000097905:Roundabout Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C066819:sli protein, Drosophila