[Effect of corticotropin on formalin-evoked c-fos expression of spinal cord and receptors analysis in rat].
OBJECTIVE
To study the effect of corticotropin (Cor) on c-fos expression induced by formalin in spinal cord of rat and the role of receptors.


METHODS
Using immunohistochemistry and adrenalectomy.


RESULTS
Cor inhibited the formalin-evoked c-fos expression in rat spinal cord in a dose-dependent manner. No obvious effect was seen by i.p. Cor 10 U.kg-1, but 25 U.kg-1 reduced the evoked c-fos expression, that was blocked by phentolamine, naloxone, or verapamil, but not much changed by adrenalectomy.


CONCLUSIONS
The formalin-evoked c-fos expression of rat spinal cord was suppressed by Cor through the alpha-adrenergic receptors, opiate receptors and calcium, but no relation to adrenal glands.
Li
H D
HD
Department of Physiology, Third Military Medical College, Chongqing, China.
Li
X C
XC
Ruan
H Z
HZ
D000315:Adrenalectomy; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D005557:Formaldehyde / Q000037:antagonists & inhibitors; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D014700:Verapamil / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D002121:Calcium Channel Blockers; D009292:Narcotic Antagonists; D016760:Proto-Oncogene Proteins c-fos; D011942:Receptors, Adrenergic, alpha; D011957:Receptors, Opioid; D005557:Formaldehyde; D009270:Naloxone; D000324:Adrenocorticotropic Hormone; D014700:Verapamil; D010646:Phentolamine