title: Effect of 5-hydroxytryptamine infusion on microcirculation in the rabbit masseter muscle measured by laser-Doppler flowmetry.
abstract: The aim was to test the hypothesis that 5-hydroxytryptamine (5-HT) influences the microcirculation of the masseter muscle. Rabbit masseters were infused with increasing concentrations of 5-HT (10(-9)-10(-5) M) on the experimental side and with saline on the control side. The effect on microcirculatory blood flow was measured by laser-Doppler flowmetry. The intramuscular temperature was recorded to monitor the influence of tissue temperature. 5-HT infusion resulted in a statistically significant decrease in blood flow at the lowest concentration (10(-9) M) (median; -11.2%: Wilcoxon signed-rank test; p<0.05). At concentrations greater than 10(-9) M, there was no significant change in blood flow. This study shows a decrease of microcirculatory blood flow in the rabbit masseter following 5-HT infusion (10(-9) M).
authors.affiliation: Department of Clinical Oral Physiology, Faculty of Dentistry, Karolinska Institutet, Huddinge, Sweden. hkurita@hsp.md.shinshu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kurita
authors.forename: M
authors.initials: M
authors.lastname: Ernberg
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: P
authors.initials: P
authors.lastname: Alstergren
authors.forename: S
authors.initials: S
authors.lastname: Kopp
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space; D007260:Infusion Pumps; D007273:Injections, Intramuscular / Q000295:instrumentation; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation; D008297:Male; D008406:Masseter Muscle / Q000098:blood supply* / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D012965:Sodium Chloride
chemical_list: D012701:Serotonin; D012965:Sodium Chloride