Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.
The inhibition of intracellular Leishmania amazonensis growth by 2', 6'-dihydroxy-4'-methoxychalcone (DMC) isolated from Piper aduncum was further enhanced after encapsulation of DMC in polymeric nanoparticles. Encapsulated DMC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the lesions.
Torres-Santos
E C
EC
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Rodrigues
J M
JM
Moreira
D L
DL
Kaplan
M A
MA
Rossi-Bergmann
B
B
D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D047188:Chalcones; D016503:Drug Delivery Systems; D005260:Female; D007891:Leishmania / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D011091:Polyesters / Q000008:administration & dosage*
C118962:2',6'-dihydroxy-4'-methoxychalcone; D000977:Antiparasitic Agents; D047188:Chalcones; D011091:Polyesters; C033616:poly(lactide); D002599:Chalcone