Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli.
Intracellular hydrogen peroxide is regulated in Escherichia coli by OxyR in response to the metabolic production of H2O2. Here, we show that the untranslated oxyS RNA controlled by OxyR has a role in this regulation. The oxyS transcript appears to affect the metabolic output of H2O2 rather than the removal of H2O2 by catalases-hydroperoxidases.
González-Flecha
B
B
Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA. bgonzale@hsph.harvard.edu
Demple
B
B
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005838:Genotype; D006861:Hydrogen Peroxide / Q000378:metabolism*; D018384:Oxidative Stress; D012329:RNA, Bacterial / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012329:RNA, Bacterial; D012097:Repressor Proteins; D014157:Transcription Factors; C499299:oxyR protein, E coli; D006861:Hydrogen Peroxide