title: Adenocarcinoma of the colon with neuroendocrine features and secretory diarrhea.
abstract: We report the case of a 63-yr-old man who had severe secretory diarrhea associated with colonic adenocarcinoma, with a prominent signet ring cell component and numerous endocrine cells as demonstrated by positive chromogranin-A staining. Improvement in the secretory diarrhea by the somatostatin analog Sandostatin suggested that the diarrhea was related to a functional neuroendocrine tumor within the colonic tumor, the first case to be reported in the literature.
authors.affiliation: CURE, Department of Medicine, UCLA Medical Center, Los Angeles, California, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Lew
authors.forename: K J
authors.initials: KJ
authors.lastname: Lewin
authors.forename: T
authors.initials: T
authors.lastname: Zarchy
authors.forename: J R
authors.initials: JR
authors.lastname: Pisegna
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology* / Q000556:secondary; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D003110:Colonic Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D003967:Diarrhea / Q000209:etiology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D053379:Chromogranin A; D002864:Chromogranins