title: HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations.
abstract: The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR=3.0, P<0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR=2.4, P<0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR=20, P<0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency(RR=0.4, P<0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplotype was observed (RR=2.0, P<0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).
authors.affiliation: Institute of Immunology, National Hospital, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Spurkland
authors.forename: S
authors.initials: S
authors.lastname: Saarinen
authors.forename: K M
authors.initials: KM
authors.lastname: Boberg
authors.forename: S
authors.initials: S
authors.lastname: Mitchell
authors.forename: U
authors.initials: U
authors.lastname: Broome
authors.forename: L
authors.initials: L
authors.lastname: Caballeria
authors.forename: E
authors.initials: E
authors.lastname: Ciusani
authors.forename: R
authors.initials: R
authors.lastname: Chapman
authors.forename: G
authors.initials: G
authors.lastname: Ercilla
authors.forename: O
authors.initials: O
authors.lastname: Fausa
authors.forename: I
authors.initials: I
authors.lastname: Knutsen
authors.forename: A
authors.initials: A
authors.lastname: Pares
authors.forename: F
authors.initials: F
authors.lastname: Rosina
authors.forename: O
authors.initials: O
authors.lastname: Olerup
authors.forename: E
authors.initials: E
authors.lastname: Thorsby
authors.forename: E
authors.initials: E
authors.lastname: Schrumpf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015209:Cholangitis, Sclerosing / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D005060:Europe; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000145:classification / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D059826:HLA-DRB3 Chains