title: Hypotensive, hypoglycaemic and toxicological studies on the flavonol C-glycoside shamimin from Bombax ceiba.
abstract: Shamimin, a C-flavonol glucoside from Bombax ceiba leaves showed significant potency as a hypotensive agent at the doses of 15 mg/kg, 3 mg/kg, 1 mg/kg and significant hypoglycaemic activity at 500 mg/kg in Sprague-Dawley rats. Further studies revealed that it did not cause any mortality in mice at the dose of 1 g/kg but in rats 500 mg/kg is a lethal dose. Aqueous and methanolic extracts of Bombax ceiba leaves and one of its fractions were also subjected to pharmacological and toxicological screening.
authors.affiliation: Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan.
authors.forename: R
authors.initials: R
authors.lastname: Saleem
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
authors.forename: S A
authors.initials: SA
authors.lastname: Hussain
authors.forename: A M
authors.initials: AM
authors.lastname: Qazi
authors.forename: S I
authors.initials: SI
authors.lastname: Ahmad
authors.forename: M H
authors.initials: MH
authors.lastname: Qazi
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.forename: S
authors.initials: S
authors.lastname: Faizi
authors.forename: S
authors.initials: S
authors.lastname: Akhtar
authors.forename: S N
authors.initials: SN
authors.lastname: Husnain
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D010944:Plants / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000959:Antihypertensive Agents; D005419:Flavonoids; D007004:Hypoglycemic Agents; C119820:shamimin; D005947:Glucose