title: Factor V Leiden, prothrombin 20210G-->A and the MTHFR C677T mutations in childhood stroke.
abstract: Ischaemic stroke is a rare occurrence in children and in a proportion of cases the aetiology remains unknown. We have investigated the role of thrombophilia in the aetiology of this condition. Of 50 cases identified at two centres, 37 were available for detailed haematological analysis. No cases were identified with deficiencies of antithrombin, protein C or protein S. One case had elevated IgG anticardiolipin antibodies at low titre. The prevalence of the prothrombin 20210 G-->A mutation, factor V Leiden (FVL) mutation and the C677T mutation in the MTHFR gene was compared in cases to that observed in random unselected cord blood controls. The odds ratio for stroke was not significantly increased in carriers of the prothrombin mutation (OR 1.2; 95% CI 0.1-10.7), FVL (OR 2.5; 95% CI 0.5-13.5), or the C677T mutation (OR 1.7; 95% CI 0.6-4.5). Our findings suggest that thrombophilia may not play a significant role in the aetiology of stroke in children, although a large prospective study is required to investigate this area further.
authors.affiliation: Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK. mmccoll@grihaem.demon.co.uk
authors.forename: M D
authors.initials: MD
authors.lastname: McColl
authors.forename: E A
authors.initials: EA
authors.lastname: Chalmers
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Sproul
authors.forename: C
authors.initials: C
authors.lastname: Healey
authors.forename: I
authors.initials: I
authors.lastname: Rafferty
authors.forename: R
authors.initials: R
authors.lastname: McWilliam
authors.forename: P
authors.initials: P
authors.lastname: Eunson
mesh_terms: D000367:Age Factors; D002561:Cerebrovascular Disorders / Q000235:genetics* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D006801:Humans; D007223:Infant; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin