[Microwave heating and neoadjuvant chemotherapy for malignant bone tumor].
Limb salvage is widely used but has different disadvantages. Attempting to establish a new limb conservative procedure, we treate patients with malignant bone tumor by intraoperative microwave heating on tumor bearing bone in place and neoadjvant chemotherapy. The tumors were localized at distal femur in 16, proximal tibia in 5, femur shaft in 2, and illia in 2. Pathological diagnosis showed osteosarcoma in 16 patents, parosteoal osteosarcoma in 4, chondrosarcoma in 3, and leiomyosarcoma in 2. The stage of tumor was II b in 18 patients, II a in 6, and III b in 3. Operative technique was wide resection for tumor in soft tissue, protecting the surrounding tissue from heat injury by copper net, and cheating tumor bone at 50 C for 15 minutes. Follow-up varied from 4 to 180 months (mean 57 months). The 5-, 10-years surviral rates were 70.19% and 54.83% respectively. Functional results of 21 patients were > 15 points by Enneking system. The advantages of the method and keeping the shape and continuity of the tumor bearing bone without osteotomy and internal fixation, controlling the time and temperature of heating treatment easily, benefiting for bone remodeling of heated bone. The indications, complications, and surgical procedure of this method were discussed in detail.
Lu
S
S
General Hospital of Chinese People's Liberation Army, Beijing.
Wang
J
J
Hu
Y
Y
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002813:Chondrosarcoma / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005266:Femoral Neoplasms / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced; D007432:Intraoperative Period; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D012516:Osteosarcoma / Q000628:therapy*; D018217:Osteosarcoma, Juxtacortical / Q000628:therapy; D015996:Survival Rate; D013977:Tibia / Q000601:surgery*