title: Efficacy of gatifloxacin in experimental Escherichia coli meningitis.
abstract: The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a beta-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime but similar to meropenem therapy (bacterial killing rates at 5 h, 0.83 +/- 0.26, 0. 46 +/- 0.3, and 0.73 +/- 0.17 CFU/ml/h, respectively; P = 0.03 for gatifloxacin versus cefotaxime). At 10 h, seven of eight animals treated with gatifloxacin had <10 CFU/ml in their cerebrospinal fluid, compared with one of seven treated with cefotaxime therapy (P = 0.01). Gatifloxacin was at least as effective as currently available antibiotics in this model of E. coli meningitis.
authors.affiliation: The University of Texas Southwestern Medical Center, Dallas, Texas 75235-9063, USA. ilutsa@mednet.swmed.edu
authors.forename: I
authors.initials: I
authors.lastname: Lutsar
authors.forename: I R
authors.initials: IR
authors.lastname: Friedland
authors.forename: H S
authors.initials: HS
authors.lastname: Jafri
authors.forename: L
authors.initials: L
authors.lastname: Wubbel
authors.forename: W
authors.initials: W
authors.lastname: Ng
authors.forename: F
authors.initials: F
authors.lastname: Ghaffar
authors.forename: G H
authors.initials: GH
authors.lastname: McCracken
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy*; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin