title: Genetic variation in the 5' end and NS5B regions of classical swine fever virus genome among Japanese isolates.
abstract: Sixteen clinical strains of classical swine fever virus (CSFV) isolated in Japan were subjected to analyses of nucleotide sequence variations in the 5' end and NS5B regions of the genome. These isolates were divided into three genovars, CSFV-1, CSFV-2 and CSFV-3, based on palindromic nucleotide substitutions at the three variable loci in the 5' untranslated region (UTR). Phylogenetic trees constructed from nucleotide sequences in the 5'-UTR and NS5B gene indicated that the CSFV strains were divided into three clusters, I, II and III. CSFV strains included in clusters I, II and III were identical to those in the CSFV-1, CSFV-2 and CSFV-3 genovars, respectively.
authors.affiliation: Animal Center for Biomedical Research, Faculty of Medicine, The University of Tokyo, Japan. ryo@m.u-tokyo.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Harasawa
authors.forename: M
authors.initials: M
authors.lastname: Giangaspero
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D006692:Classical Swine Fever Virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D004279:DNA, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D007564:Japan; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012367:RNA, Viral; D012689:Sequence Homology, Nucleic Acid; D013552:Swine; D017361:Viral Nonstructural Proteins / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D004279:DNA, Viral; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins