Preformulation stability screening of ivermectin with non-ionic emulsion excipients.
As an important and complementary step during a preformulation study differential scanning calorimetry (DSC) and high-pressure liquid chromatography (HPLC) were used to determine the compatibility between ivermectin and commonly used excipients for preparing non-ionic emulsions. Ivermectin was found to exhibit interactions with 21 excipients, while it was compatible with 25 excipients. HPLC showed a significant decrease in drug amount +20%, when substances interacted with invermectin.
Shaw
N O
NO
Research Institute for Industrial Pharmacy, Potchefstroom University for CHE, South Africa.
de Villiers
M M
MM
Lötter
A P
AP
D000871:Anthelmintics / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004655:Emulsions; D005079:Excipients; D007559:Ivermectin / Q000008:administration & dosage / Q000737:chemistry*
D000871:Anthelmintics; D004655:Emulsions; D005079:Excipients; D007559:Ivermectin