[Genetic variations of noradrenaline synthesis and reception in the mouse brain and the animal behavior in the new environment].
C57BL mice were found to have the highest locomotion and the lowest emotionality under novel environment out of three strains of mice. Their brain stem TH activity was increased whereas the density of alpha2-ARs and beta-ARs were decreased in their cortex and hypothalamus. The BALB mice were twice as virulent as the CBA mice whereas the emotionality was the same in both strains. In general, low emotionality and high locomotion in novel environment were found in mice with increased activity of norepinephrine synthesis and decreased amount of adrenergic receptors in the brain.
Dygalo
N N
NN
Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Novosibirsk, Russia.
Shishkina
G T
GT
D000223:Adaptation, Psychological; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D005106:Exploratory Behavior / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000502:physiology; D009638:Norepinephrine / Q000096:biosynthesis* / Q000235:genetics; D011941:Receptors, Adrenergic / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011941:Receptors, Adrenergic; D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine
Geneticheskie razlichiia sinteza i retseptsii noradrenalina v golovnom mozgu mysheĭ i povedenie zhivotnykh v neznakomoĭ obstanovke.