title: Moose, a new family of LTR-retrotransposons in the mosquito Anopheles gambiae.
abstract: A novel LTR retrotransposable element called moose has been cloned and characterized from the malaria transmitting mosquito, Anopheles gambiae. This element has all the characteristic features of LTR retroelements and is related to retroelements from other insects and nematodes, belonging to a subgroup of retroelements distinct from the copia/Ty1 and gypsy/Ty3 groups. The moose element appears to be active in A. gambiae, and strong RNA expression is detected in the male and female gonads. The use of this retroelement as a potential vector for germ line transformation is discussed.
authors.affiliation: Developmental Biology Center, University of California, Irvine 92697, USA. hbiessma@uci.edu
authors.forename: H
authors.initials: H
authors.lastname: Biessmann
authors.forename: M F
authors.initials: MF
authors.lastname: Walter
authors.forename: D
authors.initials: D
authors.lastname: Le
authors.forename: S
authors.initials: S
authors.lastname: Chuan
authors.forename: J G
authors.initials: JG
authors.lastname: Yao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D001483:Base Sequence; D018076:DNA, Complementary; D005260:Female; D015870:Gene Expression; D017344:Genes, Insect; D005854:Germ Cells; D019476:Insect Proteins / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D018626:Retroelements; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D020079:Terminal Repeat Sequences
chemical_list: D018076:DNA, Complementary; D019476:Insect Proteins; D018626:Retroelements; C120725:moose protein, Anopheles gambiae