title: Primary retroperitoneal soft tissue sarcomas: results of aggressive surgical treatment.
abstract: A retrospective study was undertaken to evaluate the results of surgical treatment in a series of patients with primary retroperitoneal sarcomas consecutively treated by the same surgical team. The hospital records of 42 patients with primary retroperitoneal sarcomas who underwent surgical exploration at our unit from 1984 to 1995 were reviewed. A univariate analysis was used to identify the main clinical, pathologic, and treatment-related factors affecting long-term survival. Twenty-five patients (59.6%) underwent radical surgery. The 5-year survival and 5-year disease-free survival after radical resection were 48.1% and 38.8%, respectively. According to the univariate analysis of survival tumor classification (T), stage and gross surgical margins significantly affected prognosis. The study indicates that even though there are predetermined and unmodifiable tumor-related factors, such as tumor classification (T) and stage, that influence survival in patients with retroperitoneal sarcomas, wide surgical excision offers a concrete chance for long-term survival.
authors.affiliation: Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Malerba
authors.forename: G B
authors.initials: GB
authors.lastname: Doglietto
authors.forename: F
authors.initials: F
authors.lastname: Pacelli
authors.forename: C
authors.initials: C
authors.lastname: Carriero
authors.forename: P
authors.initials: P
authors.lastname: Caprino
authors.forename: E
authors.initials: E
authors.lastname: Piccioni
authors.forename: P
authors.initials: P
authors.lastname: Crucitti
authors.forename: F
authors.initials: F
authors.lastname: Crucitti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery; D008080:Liposarcoma / Q000473:pathology / Q000601:surgery; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012186:Retroperitoneal Neoplasms / Q000145:classification / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000145:classification / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome