[ATPase activity in neurons and neuroglia during convulsions induced by picrotoxin].
Na+,K(+)-ATPase activity was studied in neurones and neuroglia under conditions of convulsions caused by picrotoxin administration. Picrotoxin is a stimulant which causes convulsions by suppression of presynaptic inhibition. Na+,K(+)-ATPase activity in neuroglia was increased in convulsion, bat was not altered in neurones. It is possible, that glial Na+, K(+)-ATPase activity plays the role of neuronal ion's flows regulator and neuronal protector from convulsions. In recovery period ATPase activities in neuronal and neuroglial cells run up to control.
Tolstukhina
T I
TI
SPb-State University, I.P. Pavlov Physiological Institute, St.-Petersburg.
Flerov
M A
MA
D000818:Animals; D003292:Convulsants / Q000633:toxicity; D008297:Male; D009457:Neuroglia / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology*; D010852:Picrotoxin / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D003292:Convulsants; D010852:Picrotoxin; D000254:Sodium-Potassium-Exchanging ATPase
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