title: Neurogenesis during caudal spinal cord regeneration in adult newts.
abstract: After tail amputation in urodele amphibians, dramatic changes appear in the spinal cord rostral to the amputation level. Transection induces a proliferation response in cells lining the ependymal canal, giving rise to an ependymal tube in which neurogenesis occurs. Using the thymidine analog bromodeoxyuridine (BrdU) in short- and long-term labeling of cells undergoing DNA synthesis (S phase of the cell cycle), specific cell markers, and cell cultures, we show that neurons derive from the proliferative ependymal layer of the ependymal tube.
authors.affiliation: Institut de Biologie du Développement de Marseille, CNRS-INSERM-Université de la Méditerranée, UMR C9943, Faculté de Luminy, F-13288 Marseille Cedex 9, France.
authors.forename: A
authors.initials: A
authors.lastname: Benraiss
authors.forename: J P
authors.initials: JP
authors.lastname: Arsanto
authors.forename: J
authors.initials: J
authors.lastname: Coulon
authors.forename: Y
authors.initials: Y
authors.lastname: Thouveny
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D002490:Central Nervous System / Q000254:growth & development*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D007150:Immunohistochemistry; D009457:Neuroglia / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010999:Pleurodeles / Q000254:growth & development / Q000502:physiology*; D012038:Regeneration; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D013623:Tail
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010751:Phosphopyruvate Hydratase