Complex vascular lesions at autopsy in a patient with phentermine-fenfluramine use and rapidly progressing pulmonary hypertension.
Anorectic agents, such as aminorex and fenfluramine derivatives, have been associated previously with the development of primary pulmonary hypertension. The combination diet drug phentermine-fenfluramine (or "phen-fen") was recently marketed in the United States. We describe a case of a 39-year-old woman with rapidly progressing, fatal pulmonary hypertension following administration of phentermine-fenfluramine. Autopsy was remarkable for complex pulmonary vascular lesions most consistent with thrombotic arteriopathy.
Strother
J
J
Department of Pathology, University of California, San Diego, La Jolla, CA 92093-0624, USA.
Fedullo
P
P
Yi
E S
ES
Masliah
E
E
D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000473:pathology; D010645:Phentermine / Q000009:adverse effects*; D011651:Pulmonary Artery / Q000187:drug effects / Q000473:pathology; D013927:Thrombosis / Q000473:pathology; D014652:Vascular Diseases / Q000139:chemically induced* / Q000473:pathology
D001067:Appetite Depressants; D005277:Fenfluramine; D010645:Phentermine