title: Ibuprofen treatment versus gradual introduction of interferon beta-1b in patients with MS.
abstract: Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.
authors.affiliation: London Health Sciences Centre, Ontario, Canada.
authors.forename: G P
authors.initials: GP
authors.lastname: Rice
authors.forename: G C
authors.initials: GC
authors.lastname: Ebers
authors.forename: F D
authors.initials: FD
authors.lastname: Lublin
authors.forename: R L
authors.initials: RL
authors.lastname: Knobler
mesh_terms: D000293:Adolescent; D000328:Adult; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000627:therapeutic use*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D000068576:Interferon beta-1b; D016899:Interferon-beta; D007052:Ibuprofen; D000068556:Interferon beta-1a