[Expression and distribution of bFGF in rat lung tissue of chronic hypoxic pulmonary hypertension].
OBJECTIVE
To evaluate the role of bFGF in the development of hypoxic pulmonary hypertension.


METHODS
Rat models with chronic hypoxia induced pulmonary hypertension were established, the pulmonary hemodynamics were measured and the pulmonary arterioles change were studied with morphometric analysis under light microscopes, immunohistochemical staining with monoclonal antibody against human recombinant bFGF was performed in the paraffin section of rat lung.


RESULTS
(1) The mean pulmonary artery pressure (mPAP), and the ratio of the thickness of pulmonary arteriolar wall to external diameter of pulmonary arterioles (MT%) were 3.96 +/- 0.47 kPa and 33.8% +/- 3.5% in rats exposed to hypoxia for 3 weeks respectively, both were significant higher than those in normal control group, P < 0.01. (2) The positive staining for bFGF in the wall of pulmonary arterioles in hypoxic rats was stronger than that of control group (P < 0.01), there was a statistical relationship between increase of staining for bFGF and MT% in rats exposed to hypoxia.


CONCLUSIONS
(1) Hypoxia can induce formation of pulmonary hypertension and structual remodeling of pulmonary arterioles. (2) bFGF may modulate the structure remodeling of pulmonary arterioles in chronic hypoxic pulmonary hypertension.
Yan
H
H
Department of Internal Medicine, First University Hospital, West China University of Medical Sciences, Chengdu.
Chen
W
W
Cheng
D
D
D000818:Animals; D001160:Arterioles / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000378:metabolism*; D000860:Hypoxia / Q000150:complications*; D008168:Lung / Q000098:blood supply; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D016222:Fibroblast Growth Factor 2