title: The toxicity of antibiotic agents to the luminescent bacterium Vibrio fischeri.
abstract: Despite their common use the fate and effects of antibiotics in the environment are largely unknown. These compounds may enter the environment through different pathways, resulting in the contamination of waste water or fresh water, where bacteria are most likely the primarily affected organisms. In this paper the toxicity of several drugs, reflecting the most important groups of antibiotics and chemotherapeutics, towards Vibrio fischeri are presented. The chronic bioluminescence inhibition assay with Vibrio fischeri is shown to be sensitive against many of the high volume antibiotics used for veterinary purposes and in aquaculture. Thus the assay may be a valuable tool for an effects assessment and biomonitoring of these xenobiotics. The available data for both parts of the risk assessment procedure--exposure assessment and effects assessment--have to be regarded as insufficient for most antibiotics. When the available data about environmental concentrations of antibiotics are compared with their toxicity towards Vibrio fischeri, direct effects on natural microbial communities are to be expected.
authors.affiliation: University of Bremen, Department of Biology/Chemistry, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Backhaus
authors.forename: L H
authors.initials: LH
authors.lastname: Grimme
mesh_terms: D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D008163:Luminescent Measurements; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018675:Toxicity Tests / Q000379:methods*; D014733:Vibrio / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004785:Environmental Pollutants