title: Creatine supplementation differentially affects maximal isometric strength and time to fatigue in large and small muscle groups.
abstract: Ten physically active, untrained, college-aged males (26.4 +/- 5. 8 years old) received creatine (CR, 5 g creatine monohydrate + 3 g dextrose) and placebo (PLA, 7 g dextrose) supplementation four times per day for 5 days in a double-blind, randomized, balanced, crossover design. Performance was assessed during maximal and three repeated submaximal bouts of isometric knee extension and handgrip exercise. CR supplementation significantly increased (p <.05) maximal isometric strength during knee extension but not during handgrip exercise. CR supplementation increased time to fatigue during each of the three bouts of submaximal knee extension and handgrip exercise when compared to the PLA trials. These findings suggest that CR supplementation can increase maximal strength and time to fatigue during isometric exercise. However, the improvements in maximal isometric strength following CR supplementation appear to be restricted to movements performed with a large muscle mass.
authors.affiliation: Exercise Biochemistry Laboratory, Department of Kinesiology, California State University - Northridge, 18111 Nordhoff Street, Northridge, CA 91330-8287, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Urbanski
authors.forename: W J
authors.initials: WJ
authors.lastname: Vincent
authors.forename: B B
authors.initials: BB
authors.lastname: Yaspelkis
mesh_terms: D000328:Adult; D003401:Creatine / Q000008:administration & dosage*; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004311:Double-Blind Method; D018737:Hand Strength; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects*; D008297:Male; D018763:Muscle Fatigue / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology*; D010919:Placebos; D013997:Time Factors
chemical_list: D010919:Placebos; D003401:Creatine