title: A pilot study of iron depletion as adjuvant therapy in chronic hepatitis C patients not responding to interferon.
abstract: The aim of this study was to assess the efficacy of iron depletion obtained by phlebotomy to enhance interferon response in 11 patients who had failed to respond to a standard 3-month interferon treatment. Despite a significant effect on serum aminotransferase levels, there was no effect on viremia, and iron depletion was unable to trigger interferon response.
authors.affiliation: Clinique des Maladies du Foie et Inserm U49, Laboratoire de Virologie de l'Université de Rennes, France.
authors.forename: D
authors.initials: D
authors.lastname: Guyader
authors.forename: E
authors.initials: E
authors.lastname: Boucher
authors.forename: P
authors.initials: P
authors.lastname: André
authors.forename: C
authors.initials: C
authors.lastname: Even
authors.forename: J
authors.initials: J
authors.lastname: Cottereau
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: P
authors.initials: P
authors.lastname: Gasser
authors.forename: M H
authors.initials: MH
authors.lastname: Mendler
authors.forename: Y
authors.initials: Y
authors.lastname: Deugnier
authors.forename: P
authors.initials: P
authors.lastname: Brissot
mesh_terms: D000328:Adult; D004351:Drug Resistance; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007501:Iron / Q000037:antagonists & inhibitors* / Q000097:blood; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D010865:Pilot Projects; D012367:RNA, Viral / Q000097:blood
chemical_list: D012367:RNA, Viral; D007372:Interferons; D007501:Iron