Identification of human herpesvirus 8-specific cytotoxic T-cell responses.
Human herpesvirus 8 (HHV-8) (or Kaposi's sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi's sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.
Osman
M
M
Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, University College London, London, United Kingdom.
Kubo
T
T
Gill
J
J
Neipel
F
F
Becker
M
M
Smith
G
G
Weiss
R
R
Gazzard
B
B
Boshoff
C
C
Gotch
F
F
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000821:virology; D000818:Animals; D002460:Cell Line; D002461:Cell Line, Transformed; D006224:Cricetinae; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; C111600:K1 protein, Human herpesvirus 8; C113454:K8.1 protein, Human herpesvirus 8; D009856:Oncogene Proteins, Viral; C100440:T0.7 protein, Human herpesvirus 8; D014764:Viral Proteins