title: Immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection in a dog.
abstract: A three-year-old weimaraner was presented with lethargy, anorexia, neck pain and a soft fluctuant swelling in the thoracic inlet. A cough had been noted previously. Clinical examination revealed tachycardia, tachypnoea, pallor and a large subcutaneous swelling, with bruising, suggestive of a haematoma in the thoracic inlet. Thoracic radiographs revealed a cranial mediastinal mass which had the ultrasonographic appearance of fluid, and there was also a marked generalised interstitial lung pattern. Routine haematology revealed severe anaemia and thrombocytopenia, although coagulation tests were within normal limits. A diagnosis of immune-mediated thrombocytopenia was however made on the basis of a positive antiplatelet antibody test and a rapid response to prednisolone therapy. Furthermore, a tentative diagnosis of Angiostrongylus vasorum infection was suggested on the basis of clinical and radiographic findings, although no lungworm larvae were identified on faecal analysis. Despite initiating treatment with fenbendazole, the dog died suddenly. Postmortem examination revealed myocarditis, thrombosing arteritis, pneumonia and chronic membranoproliferative glomerulonephritis associated with A vasorum infection.
authors.affiliation: Department of Clinical Veterinary Medicine, Queen's Veterinary School Hospital, Cambridge.
authors.forename: S M
authors.initials: SM
authors.lastname: Gould
authors.forename: E L
authors.initials: EL
authors.lastname: McInnes
mesh_terms: D000801:Angiostrongylus; D000818:Animals; D001167:Arteritis / Q000150:complications / Q000662:veterinary; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D004285:Dogs; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000662:veterinary; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000662:veterinary; D011014:Pneumonia / Q000150:complications / Q000662:veterinary; D017206:Strongylida Infections / Q000150:complications / Q000000981:diagnostic imaging / Q000662:veterinary*; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D014463:Ultrasonography