title: Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives.
abstract: Bovine lactoferrin (LF) and lactoferricin B (LFcin B), an antimicrobial peptide derived from bovine LF, inhibited thiobarbituric acid-reactive substance (TBARS) formation in a iron/ascorbate-induced liposomal phospholipid peroxidation system. The inhibition of TBARS formation occurred with N-acylated 9-mer peptides with a core sequence of LFcin B and, compared to LFcin B, their antioxidant effect was clearly observed at a concentration almost 100 times lower.
authors.affiliation: Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan. Hiroyuki_Wa@msn.com
authors.forename: H
authors.initials: H
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Teraguchi
authors.forename: M
authors.initials: M
authors.lastname: Takase
authors.forename: H
authors.initials: H
authors.lastname: Hayasawa
mesh_terms: D000215:Acylation; D000595:Amino Acid Sequence; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002417:Cattle; D007501:Iron / Q000494:pharmacology*; D007781:Lactoferrin / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D017392:Thiobarbituric Acid Reactive Substances; D007501:Iron; D007781:Lactoferrin; D001205:Ascorbic Acid