title: [Intracerebral hemorrhage associated with long-lasting deficiency of factor XIII].
abstract: A 5-year-old boy had an intracerebral hematoma evacuated from the left parieto-occipital region at a local hospital. There was a difficulty in hemostasis during the operation. Postoperatively his neurological state gradually deteriorated. CT scans showed a gradual increase in intracerebral hemorrhage at the operated site. He was transferred to our clinic for further treatment. The preoperative blood coagulation profile showed that the activity of factor XIII was only 4%. The hematoma was removed without any trouble under administration of factor XIII. Postoperative course was also uneventful although the plasma level of factor XIII did not go up higher than 26% in spite of its daily administration. Although factor XIII administration was terminated one month after cranioplasty, the patient showed good recovery and the level of factor XIII spontaneously normalized in 6 months. The cause of the extremely low level of factor XIII in this case is not known, but it could be ascribed to massive hemorrhage.
authors.affiliation: Department of Neurosurgery, Shiga University of Medical Science, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: J
authors.initials: J
authors.lastname: Handa
authors.forename: M
authors.initials: M
authors.lastname: Hayami
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Ohta
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications* / Q000601:surgery; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005176:Factor XIII / Q000378:metabolism; D005177:Factor XIII Deficiency / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male
chemical_list: D005176:Factor XIII