[The role of endothelium in normal pregnancy and pregnancy complicated by preeclampsia].
Endothelial cell dysfunction is thought to play a role in preeclampsia and the reduced production by vascular endothelial cells of the antiaggregatory and vasodilatory factors is well documented. The present study was designed to evaluate endothelial cells function in preeclamptic and healthy pregnant subjects. The nitric oxide plasma concentration in women with preeclampsia was significantly lower as compared with normotensive pregnant women. A significant increase in ET concentration was found in preeclamptic women as compared with normal pregnant patients and normal non-pregnant. The plasma concentrations of von Willebrand factor were significantly increased in healthy pregnancy as compared with preeclamptic patients. The results of our study demonstrate a significant endothelial cells damage in preeclamptic patients. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.
Bielecki
M
M
Kliniki Połoznictwa Instytutu Połoznictwa i Chorób Kobiecych AM w Białymstoku.
Jarocki
S
S
Bodzenta-Lukaszyk
A
A
Zdrodowska
J
J
Bielecki
D A
DA
Tomasiak
M
M
D000328:Adult; D004727:Endothelium; D004730:Endothelium, Vascular / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000097:blood; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000032:analysis
D014841:von Willebrand Factor; D009569:Nitric Oxide
Rola śródbłonka naczyniowego w ciazy prawidłowej i powikłanej EPH gestoza.