Sialyl Lewis X expression in vascular permeating lesions as a factor for predicting colorectal cancer metastasis.
OBJECTIVE
To evaluate the potential of sialyl Lewis X (SLX) expression for predicting residual liver recurrence, we examined the vascular permeating lesions surrounding the metastatic liver tumors for SLX as a marker of residual liver recurrence.


METHODS
Twenty-eight cases of metastatic liver tumors of colorectal cancers were examined using SLX monoclonal antibody for SLX expression in surrounding vascular permeating lesions.


RESULTS
The cumulative residual liver recurrence rate in cases positive for SLX (SLX(+)) expression in the vascular permeating lesions surrounding the metastatic liver tumor was significantly higher than in the negative cases (p < 0.05). Furthermore, logistic regression analysis revealed that SLX positivity in the lesions surrounding the metastatic liver tumor was an important discriminant for residual liver recurrence (p = 0.0197).


CONCLUSIONS
These results indicated that SLX expression in vascular permeating lesions surrounding the metastatic liver tumor is a predictive factor for residual liver recurrence.
Tanaka
K
K
Second Department of Surgery, Yokohama City University School of Medicine, Japan.
Togo
S
S
Nanko
M
M
Ishikawa
T
T
Ichikawa
Y
Y
Yamaoka
H
H
Shimada
H
H
D014408:Biomarkers, Tumor / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D018365:Neoplasm, Residual / Q000235:genetics* / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D009844:Oligosaccharides / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D000080506:Sialyl Lewis X Antigen
D014408:Biomarkers, Tumor; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen