Thermodynamic influences on the fidelity of iron-sulphur cluster formation in proteins.
In an organism, two thermodynamic factors are important in ensuring that homometallic [4Fe-4S] cubane clusters are formed in preference to clusters containing heterometals such as Zn or Cu. These are the electronic resonance stabilisation, which boosts the binding of Fe(II) within an Fe-S cluster relative to its normally low position in the Irving-Williams order, and attenuation of the cytoplasmic concentrations of competing metals such as Zn or Cu by specific ligands.
Armstrong
F A
FA
Inorganic Chemistry Laboratory, Oxford, UK.
Williams
R J
RJ
D005288:Ferredoxins / Q000737:chemistry; D006706:Homeostasis; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D013455:Sulfur / Q000737:chemistry*; D013816:Thermodynamics
D005288:Ferredoxins; D013455:Sulfur; D007501:Iron