Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level.
In this article we first very briefly review current approaches to the design of drugs that have specificity for the modulation of gene expression and selectivity for target cells at the transcription level by targeting DNA. We focus this review on our approaches to gaining selectivity by drug-induced architectural alteration in DNA structure, selectivity achieved by protein-induced changes in DNA structure or dynamics, and hijacking of nuclear receptors.
Zewail-Foote
M
M
Department of Chemistry and Biochemistry, University of Texas at Austin 78712, USA.
Hurley
L H
LH
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D015195:Drug Design; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D014158:Transcription, Genetic / Q000187:drug effects* / Q000235:genetics
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm