title: Electrochemical behaviour of Venlafaxine and its determination in pharmaceutical products using square wave voltammetry.
abstract: An electrochemical method for the determination of Venlafaxine in pharmaceutical formulations recently available on the European market is described. The electrochemical oxidation of Venlafaxine was studied at a HMDE electrode over a wide pH range (1.9-10.0) of buffered aqueous solutions using different potential sweep techniques. The results obtained showed that the best definition of the analytical signals was found in boric acid/potassium tetrahydroxoborate buffer at pH 8.7 using anodic stripping square wave voltammetry. Recovery trials were performed to assess the accuracy of results and these were compared to those provided by a HPLC technique according to the method described in literature and to the features of the pharmaceutical formulations. A relative deviation of < 0.2% was obtained. With the developed methodology, the limit of detection was 0.124 mg/l.
authors.affiliation: CEQUP/Departamento de Química-Física, Faculdade de Farmácia da Universidade do Porto, Portugal.
authors.forename: J L
authors.initials: JL
authors.lastname: Lima
authors.forename: D V
authors.initials: DV
authors.lastname: Loo
authors.forename: C
authors.initials: C
authors.lastname: Delerue-Matos
authors.forename: A S
authors.initials: AS
authors.lastname: da Silva
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000737:chemistry*; D003511:Cyclohexanols / Q000737:chemistry*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D012996:Solutions; D000069470:Venlafaxine Hydrochloride