Colony stimulating factor-inducing activity of hesperidin.
To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.
Kawaguchi
K
K
Kikuchi
S
S
Takayanagi
K
K
Yoshikawa
T
T
Kumazawa
Y
Y
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D006569:Hesperidin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL
D000276:Adjuvants, Immunologic; D003115:Colony-Stimulating Factors; D006569:Hesperidin