Giant cell angiofibroma of the orbit and eyelid.
OBJECTIVE
To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma.


METHODS
Observational case series.


METHODS
Clinical and histopathologic features of giant cell angiofibroma.


METHODS
Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma.


RESULTS
A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin.


CONCLUSIONS
Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.
Hayashi
N
N
Wilmer Ophthalmological Institute, and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Borodic
G
G
Karesh
J W
JW
Tolentino
M J
MJ
Remulla
H D
HD
Van Wesep
R A
RA
Grossniklaus
H E
HE
Jakobiec
F A
FA
Green
W R
WR
D000368:Aged; D018322:Angiofibroma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D018952:Antigens, CD34 / Q000032:analysis; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005870:Giant Cell Tumors / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
D018952:Antigens, CD34; D014746:Vimentin