title: [The relationship between interleukin-8 and airway hyperresponsiveness].
abstract: OBJECTIVE
  To explore the relationship between interleukin-8 (IL-8) and airway hyperresponsiveness (AHR) of asthma.
  
  
  METHODS
  IL-8 at a dose of 0.5 microgram/kg or 5 micrograms/kg was administered intranasally to guinea-pigs twice a week for 3 weeks. 24 hours after the last administration, airway responsiveness was measured as an overall index of airway response to increasing concentrations of inhaled histamine (25, 50, 100 and 200 micrograms/ml) and the numbers of different inflammatory cells in bronchoalveolar lavage fluid (BALF) was counted.
  
  
  RESULTS
  The IL-8 treatment significantly enhanced airway responsiveness to histamine in a dose-dependent manner (P < 0.05 or 0.01) and induced a significant influx of neutrophils in BALF (P < 0.01), and there are many neutrophils within airway wall but not control animals treated with phosphate buffered saline (PBS).
  
  
  CONCLUSIONS
  The IL-8 given into the airways can produce neutrophil inflammation of the airways and induce AHR, it may play an important role in asthma, especially in the development of AHR.
authors.affiliation: Xijing Hospital Fourth Military Medical University, Xi'an.
authors.forename: K
authors.initials: K
authors.lastname: Lü
authors.forename: H
authors.initials: H
authors.lastname: Qi
authors.forename: W
authors.initials: W
authors.lastname: Wang
mesh_terms: D000818:Animals; D001249:Asthma / Q000139:chemically induced* / Q000473:pathology; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D006168:Guinea Pigs; D016209:Interleukin-8; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils / Q000187:drug effects*
chemical_list: D016209:Interleukin-8