Histologic evaluation of clinically successful osseointegrated implants retrieved from irradiated bone: a report of 2 patients.
The present study described the histologic findings of 2 implants and surrounding tissues retrieved from human irradiated bone. For the treatment of a malignant tumor, 50 Gy of irradiation after implant placement and 60 Gy of irradiation before implant placement were provided for patients 1 and 2, respectively. In patient 1, the implant and surrounding tissues were removed from the frontal bone 24 months after implant placement because of the patient's death from a tumor recurrence. In patient 2, the implant and surrounding tissue were removed from a maxillectomy site 26 months after implant placement because of tumor recurrence. In each patient, new bone formation surrounding the implants was observed. The ratio of direct bone-implant contact along the threaded implant surface was 61.3% in patient 1 and 69.0% in patient 2. The ratio of the area occupied by mineralized bone in each thread was 75.8% in patient 1 and 81.2% in patient 2. These results indicate the potential of irradiated bone to achieve osseointegration of titanium implants.
Nakai
H
H
Department of Oral Surgery, Nagoya University School of Medicine, Japan.
Niimi
A
A
Ueda
M
M
D000230:Adenocarcinoma / Q000532:radiotherapy / Q000601:surgery; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D002610:Cheek; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008447:Maxillofacial Prosthesis; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000601:surgery; D020273:Orbital Implants; D016348:Osseointegration / Q000528:radiation effects*; D016896:Treatment Outcome