Gabapentin for self-injurious behavior in Lesch-Nyhan syndrome.
Self-injurious behavior is a common clinical problem in children with Lesch-Nyhan syndrome, an X-linked disorder of purine metabolism. This behavior is not observed in other conditions associated with increased serum concentrations of uric acid, hypoxanthine, and xanthine. Various neurotransmitters appear to play a pivotal role in self-injurious behavior. The authors present a patient with Lesch-Nyhan syndrome, whose self-injurious behavior was effectively treated with gabapentin, and discuss possible mechanisms of action.
McManaman
J
J
Department of Pediatrics and Clinical Investigations, Naval Medical Center San Diego, California 92134-1005, USA.
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D000085:Acetates / Q000627:therapeutic use*; D000588:Amines; D002675:Child, Preschool; D003509:Cyclohexanecarboxylic Acids; D018755:GABA Agonists / Q000627:therapeutic use*; D000077206:Gabapentin; D006801:Humans; D007926:Lesch-Nyhan Syndrome / Q000188:drug therapy*; D008297:Male; D016728:Self-Injurious Behavior / Q000188:drug therapy*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018755:GABA Agonists; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin