title: Current source-density analysis of light-evoked field potentials in rabbit retina.
abstract: The technique of current source-density analysis was applied to several components of the light-evoked field potentials (electroretinogram) from the retina of the superfused eyecup of rabbit. The depth distributions of the major current sources and sinks were: b-wave--sink at outer plexiform layer, source at inner plexiform layer; M-wave--sink at inner plexiform layer, source at retinal surface; and slow PIII--source near outer plexiform layer, sink at retinal surface. These distributions, along with the sensitivities of these responses to certain pharmacological agents, support earlier studies that Müller cells generate the M-wave and slow PIII, but that depolarizing bipolar cells directly generate the b-wave.
authors.affiliation: Department of Psychology, University of Georgia, Athens 30602, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Karwoski
authors.forename: X
authors.initials: X
authors.lastname: Xu
mesh_terms: D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D017609:Barium Compounds / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D004596:Electroretinography; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007736:Kynurenic Acid / Q000494:pharmacology; D008027:Light; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D010775:Photic Stimulation; D010852:Picrotoxin / Q000494:pharmacology; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology*
chemical_list: D000613:Aminobutyrates; D017609:Barium Compounds; D002712:Chlorides; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D007736:Kynurenic Acid; D010852:Picrotoxin; C024986:barium chloride; C012729:2-amino-4-phosphonobutyric acid