Regulation of an 8-kDa peptide involved in testosterone production by luteinizing hormone in rat Leydig cells.
Results of Western blot analysis carried out with an interstitial cell extract from male guinea pig and ovarian extract from immature female rats administered equine chorionic gonadotropin (eCG) provide supportive evidence to our earlier suggestion that an 8-kDa peptide is involved in acquisition of steroidogenic capacity by the rat Leydig cells. It was found that though the signal was observed in other tissues such as liver, kidney and lung which do not produce gonadal hormones, the peptide was modulated only by lutenizing hormone (LH) in the rat Leydig cells.
Ramaraj
P
P
Department of Diabetes, Endocrinology & Metabolism, University of Hope National Medical Centre, Duarte, CA 91007, USA.
Rao
A J
AJ
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D006801:Humans; D007985:Leydig Cells / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010455:Peptides / Q000378:metabolism*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000096:biosynthesis*; D014018:Tissue Distribution
D010455:Peptides; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone