title: Effects of prolactin and growth hormone on plasma immunoglobulin M levels of hypophysectomized rainbow trout, Oncorhynchus mykiss.
abstract: Immunoglobulin M (IgM) is a major component of the humoral immune system of teleosts. This study examines the effects of hypophysectomy and subsequent replacement with prolactin (PRL) or growth hormone (GH) upon the plasma IgM levels of the rainbow trout (Oncorhynchus mykiss). Plasma IgM levels of the hypophysectomized fish were decreased to 30% of those in sham-operated fish 1 or 4 weeks after operation. Implantation of a cholesterol pellet containing salmon PRL or GH restored plasma IgM levels of the hypophysectomized fish, suggesting important roles for PRL and GH in the regulation of circulating IgM level in trout.
authors.affiliation: Nikko Branch, National Research Institute of Aquaculture, Nikko, Tochigi, 321-1661, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yada
authors.forename: M
authors.initials: M
authors.lastname: Nagae
authors.forename: S
authors.initials: S
authors.lastname: Moriyama
authors.forename: T
authors.initials: T
authors.lastname: Azuma
mesh_terms: D000818:Animals; D004343:Drug Implants; D013006:Growth Hormone / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007016:Hypophysectomy; D007075:Immunoglobulin M / Q000097:blood*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D011388:Prolactin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D004343:Drug Implants; D007075:Immunoglobulin M; D011388:Prolactin; D013006:Growth Hormone