[Radioprotective effect of lymphokinine].
It is shown that lymphokinine, cytokine complex, i. a. applied in mice (50,000 U/kg) 24 hours before the following acute of prolonged irradiation in dose LD50-85/30 increases animal survival by 30-40%. Lymphokinine shifts down the expression of postradiational leucopenia, significantly accelerates leucocytes and myelokaryocyte recovery and stimulates colony-forming ability of bone marrow cells in irradiated animals. Lymphokinine induced increase of endogenous radioresistance rate is suggested to be associated with its ability to accelerate early haemopoietic cells proliferative and migration activity and modify cells cycle of marrow haemopoietic cells.
Legeza
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Research Institute of Military Medicine, Russian Defence Ministry, St.-Petersburg.
Bel'skiĭ
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D000818:Animals; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D007958:Leukocyte Count; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D008533:Megakaryocytes / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D008222:Lymphokines; D011837:Radiation-Protective Agents
Radiozashchitnoe deĭstvie limfokinina.