title: Uptake of pyocin S3 occurs through the outer membrane ferripyoverdine type II receptor of Pseudomonas aeruginosa.
abstract: Pyocin S3 was found to kill exclusively Pseudomonas aeruginosa isolates producing type II pyoverdine (exemplified by strain ATCC 27853). Killing was specifically inhibited by addition of type II ferripyoverdine. All Tn5 mutants resistant to pyocin S3 were defective for pyoverdine-mediated iron uptake and failed to produce an 85-kDa iron-repressed outer membrane protein. We conclude that this protein is probably the type II ferripyoverdine receptor that is used by pyocin S3 to gain entry into the cell.
authors.affiliation: Laboratoire de Bactériologie, Faculté de Médecine, Université de Franche-Comté, 25030 Besançon, France.
authors.forename: C
authors.initials: C
authors.lastname: Baysse
authors.forename: J M
authors.initials: JM
authors.lastname: Meyer
authors.forename: P
authors.initials: P
authors.lastname: Plesiat
authors.forename: V
authors.initials: V
authors.lastname: Geoffroy
authors.forename: Y
authors.initials: Y
authors.lastname: Michel-Briand
authors.forename: P
authors.initials: P
authors.lastname: Cornelis
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism* / Q000494:pharmacology; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003550:Cystic Fibrosis / Q000382:microbiology; D006801:Humans; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology; D016254:Mutagenesis, Insertional; D009842:Oligopeptides; D010860:Pigments, Biological / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000302:isolation & purification / Q000502:physiology*; D011709:Pyocins / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C082326:FpvA protein, Pseudomonas aeruginosa; D007502:Iron Chelating Agents; D009842:Oligopeptides; D010860:Pigments, Biological; D011709:Pyocins; C093129:pyocin S3 protein, Pseudomonas aeruginosa; C042453:pyoverdin; D007501:Iron