[Transit stage of the long-term facilitation in command neurons of the defensive behavior in sensitized snails].
Sensitising stimuli caused a synaptic facilitation of the Helix lucorum of responses to testing sensory stimulation which lasted over 24 hrs. Following a single stimulus, the facilitation was transient. The same facilitation occurred after 5-HT or cAMP application. Calmodulin and glutamate NMDA-receptor antagonists, as well as the protein synthesis inhibitors suppressed the facilitation in command neurones. The transient synaptic facilitation seems to involve processes of translation/transcription and subsequent synthesis of synapse-specific protein molecules with short life-time.
Nikitin
V P
VP
P. K. Anokhin Institute of Normal Physiology, Moscow, Russia.
D000818:Animals; D002147:Calmodulin / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology; D004924:Escape Reaction / Q000502:physiology*; D006372:Helix, Snails; D009474:Neurons / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D010812:Physical Stimulation; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D011803:Quinine / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D002147:Calmodulin; D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D012701:Serotonin; D011803:Quinine; D000242:Cyclic AMP
Tranzitnaia stadiia dolgovremennogo sinapticheskogo oblegcheniia u kommandnykh neĭronov oboronitel'nogo povedeniia sensitizirovannykh ulitok.