Sinonasal cancer, occupation, and tobacco smoking in European women and men.
BACKGROUND
In this analysis of European case-control studies on sinonasal cancer, we examined the risk for occupation and smoking, by gender and histological type.


METHODS
The pooled data included 104 female and 451 male cases, and 241 female and 1,464 male controls. Lifetime smoking and occupational history were recoded following uniform criteria, and job-exposure matrices were applied for wood and leather dust.


RESULTS
Wood dust exposure was associated with an excess risk in men (OR = 2.36, 95% CI 1.75-3.2) but not in women (OR = 1.17, 95% CI 0.31-4.47). Exposure to leather dust was associated with an excess risk in both genders. Both wood and leather dust were associated with adenocarcinomas rather than squamous cell carcinomas. Excess risks for smoking were higher for squamous cell carcinomas and higher in men than in women.


CONCLUSIONS
In these European populations, occupation was associated with about 11% of all sinonasal cancers in women and 39% in men. This difference can, in part, be attributed to variation in exposure patterns between genders.
't Mannetje
A
A
Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain.
Kogevinas
M
M
Luce
D
D
Demers
P A
PA
Bégin
D
D
Bolm-Audorff
U
U
Comba
P
P
Gérin
M
M
Hardell
L
L
Hayes
R B
RB
Leclerc
A
A
Magnani
C
C
Merler
E
E
Tobías
A
A
Boffetta
P
P
D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D004198:Disease Susceptibility / Q000453:epidemiology; D004391:Dust / Q000009:adverse effects; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D009669:Nose Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D009790:Occupations / Q000145:classification / Q000706:statistics & numerical data; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects* / Q000453:epidemiology; D013223:Statistics as Topic
D004391:Dust