title: The pathogenesis of vascular thrombosis and its impact in microvascular surgery.
abstract: As the use of free tissue transfer becomes more wide-spread, it is important for both the ablative surgeon and the reconstructive surgeon to understand the factors that contribute to successful revascularized tissue transfer. The purpose of this two part review is to provide a basic science overview of the problem of failed free tissue transfers. The first part will focus on the pathogenesis of thrombosis at the anastomotic site, and part two will discuss the pathogenesis of the no-reflow phenomenon. The pathophysiology and therapeutic interventions to prevent and treat anastomotic thrombosis and the no-reflow phenomenon will be discussed.
authors.affiliation: Department of Otolaryngology and Communicative Disorders, The Cleveland Clinic Foundation, OH 44195, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Esclamado
authors.forename: W R
authors.initials: WR
authors.lastname: Carroll
mesh_terms: D000714:Anastomosis, Surgical; D001777:Blood Coagulation / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008866:Microsurgery; D018579:Patient Selection; D010974:Platelet Aggregation / Q000502:physiology; D011183:Postoperative Complications / Q000503:physiopathology* / Q000517:prevention & control; D012039:Regional Blood Flow / Q000502:physiology; D013300:Streptokinase / Q000627:therapeutic use; D013524:Surgical Flaps / Q000098:blood supply*; D014656:Vascular Surgical Procedures; D020246:Venous Thrombosis / Q000503:physiopathology* / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase