title: Assessment of bronchial reactivity by forced oscillation admittance avoids the upper airway artefact.
abstract: The forced oscillation technique (FOT) allows easy assessment of bronchial reactivity. The use of a standard FOT generator (SG) results in changes in respiratory system resistance (delta Rrs,SG) which are affected by an artefact caused by the extrathoracic upper airway (EUA). The aim was to improve the FOT assessment of bronchial reactivity with the SG by computing the change in FOT admittance (delta Ars,SG), which is theoretically unaffected by this artefact. Delta Rrs,SG and delta Ars,SG after bronchial challenge in 17 children were compared with the values measured with a head generator (HG) FOT setup (delta Rrs,HG and delta Ars,HG, respectively), which were taken as a reference, since HG provides data virtually freed from the EUA artefact. At 10 Hz, the SG significantly underestimated the resistance change: delta Rrs,SG=1.77+/-0.62 versus delta Rrs,HG=6.09+/-1.23 hPa x L(-1) x s. Delta Rrs,SG and delta Rrs,HG did not show a significant correlation. By contrast, the amplitude of the change in admittance measured by SG was close to the one obtained with the reference HG: /delta Ars,SG/=29.5+/-4.6 versus /delta Ars,HG/=32.7+/-3.9 mL x hPa(-1) x s(-1). /Delta Ars,SG/ and /delta Ars,HG/ showed a significant correlation (r=0.65, p>0.01). Similar results were found up to 20 Hz. The extrathoracic upper airway artefact was minimized when computing the change in admittance with the standard generator. This forced oscillation technique index may improve the sensitivity in assessing bronchial reactivity with the standard generator setup, which is the most common and easiest to use method for routine lung function testing.
authors.affiliation: Laboratori de Biofisica i Bioenginyeria, Facultat de Medicina, Institut d'Investigacions Biomediques Agusti Pi Sunyer, Universitat de Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Farré
authors.forename: M
authors.initials: M
authors.lastname: Rotger
authors.forename: F
authors.initials: F
authors.lastname: Marchal
authors.forename: R
authors.initials: R
authors.lastname: Peslin
authors.forename: D
authors.initials: D
authors.lastname: Navajas
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D016477:Artifacts; D016535:Bronchial Hyperreactivity / Q000175:diagnosis*; D006801:Humans; D009991:Oscillometry / Q000379:methods; D012129:Respiratory Function Tests / Q000379:methods; D015656:Respiratory Mechanics / Q000502:physiology; D012680:Sensitivity and Specificity