[Dependence of myocardial damage on the anion composition and osmotic pressure in the extracellular fluid during "calcium paradox" in rats].
The data obtained reveal that elevation of extracellular osmolarity with sucrose during reintroduction of Ca-containing medium after 10 minutes of Ca2+ removal prevents loss of haemoglobin in a concentration-dependent mode. Reducing the extracellular osmolarity of the reperfusion medium by means of decreasing the concentration of sodium chloride and calcium chloride exacerbates the loss of haemoglobin from the cardiomyocytes. There is a close correlation between the water contents in tissues and the loss of haemoglobin during the "calcium paradox". The findings suggest dependence of the heart damage during the "calcium paradox" on anionic composition of extracellular space and activity of anionic transporters.
Alabovskiĭ
V V
VV
Voronezh State Medical Academy, Russia.
Cragoe
E
E
Dmitrashchuk
A I
AI
Vinokurov
A A
AA
D000818:Animals; D027321:Anion Transport Proteins; D017920:Antiporters / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D048429:Cell Size; D018118:Chloride Channels / Q000378:metabolism; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides / Q000378:metabolism / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009211:Myoglobin / Q000378:metabolism; D009997:Osmotic Pressure; D010477:Perfusion; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology
D027321:Anion Transport Proteins; D017920:Antiporters; D001639:Bicarbonates; D002352:Carrier Proteins; D018118:Chloride Channels; D027963:Chloride-Bicarbonate Antiporters; D002712:Chlorides; D009211:Myoglobin; D013395:Sucrose; D012964:Sodium; D002118:Calcium
Zavisimost' povrezhdeniĭ serdtsa krys pri "kal'tsievom paradokse" ot anionnogo sostava i osmoticheskogo davleniia vnekletochnoĭ sredy.