title: Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma.
abstract: OBJECTIVE
  To determine whether analysis of sequential optic disc images obtained with the Heidelberg retina tomograph (HRT) is able to demonstrate optic disc change before the development of reproducible field defects in a group of ocular hypertensive (OHT) patients converting to early glaucoma.
  
  
  METHODS
  Two groups were analysed: (1) 13 eyes of 13 OHT patients who subsequently developed reproducible field defects (converters); and (2) 13 eyes of 11 normal control subjects. Two sequential optic disc images were obtained using the HRT (median separation between images was 12 months for the converters and 13 months for the normals). The second image in the converter group was obtained before confirmed visual field loss. The optic disc variables were analysed both globally and segmentally using HRT software version 1.11. The Wilcoxon signed rank test was used to determine if there were any significant differences between the variables of the two image sets.
  
  
  RESULTS
  Significant optic disc change was demonstrated in the group of converters: (1) global variables: the cup area increased by 9.7%, the C/D area ratio increased by 10.5%, and the rim area decreased by 6.9%; (2) segmental variables: the superonasal cup area increased by 11.0%, the superonasal C/D area ratio increased 11.7%, and the inferonasal cup volume increased by 28.4%. The temporal rim volume decreased by 15.6%, the inferotemporal rim volume decreased by 23.6%, and the rim area in the superonasal and superotemporal segments decreased by 6.6% and 6.9% respectively.
  
  
  CONCLUSIONS
  Analysis of sequential optic disc images on the HRT allowed the detection of glaucomatous change before confirmed visual field change in a group of OHT patients converting to early glaucoma.
authors.affiliation: Glaucoma Unit, Moorfields Eye Hospital London.
authors.forename: D S
authors.initials: DS
authors.lastname: Kamal
authors.forename: A C
authors.initials: AC
authors.lastname: Viswanathan
authors.forename: D F
authors.initials: DF
authors.lastname: Garway-Heath
authors.forename: R A
authors.initials: RA
authors.lastname: Hitchings
authors.forename: D
authors.initials: D
authors.lastname: Poinoosawmy
authors.forename: C
authors.initials: C
authors.lastname: Bunce
mesh_terms: D000368:Aged; D018450:Disease Progression; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009798:Ocular Hypertension / Q000473:pathology* / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology*; D014054:Tomography; D014794:Visual Fields