title: Pharmacokinetics of antipyrine, warfarin and paracetamol in the brushtail possum.
abstract: The plasma pharmacokinetics of antipyrine, warfarin and paracetamol have been studied in the Australian brushtail possum (Trichosurus vulpecula). The plasma elimination half-lives (t1/2) were 1.2 h for antipyrine, 11.9 h for warfarin and 5.2-12.9 h for paracetamol. Our data indicate that the clearance of these three xenobiotics in the possum is similar to that reported in eutherian mammals. There was no dose-dependent increase in paracetamol plasma t1/2 over the dose range 100-1000 mg kg(-1), indicating a lack of capacity saturation. This observation may in part explain the unusual resistance of the possum to the hepatotoxic effect of high doses of paracetamol.
authors.affiliation: Landcare Research, Lincoln, New Zealand.
authors.forename: C T
authors.initials: CT
authors.lastname: Eason
authors.forename: G R
authors.initials: GR
authors.lastname: Wright
authors.forename: R
authors.initials: R
authors.lastname: Gooneratne
mesh_terms: D000082:Acetaminophen / Q000097:blood / Q000493:pharmacokinetics; D018712:Analgesics, Non-Narcotic / Q000493:pharmacokinetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics; D000925:Anticoagulants / Q000493:pharmacokinetics; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D008297:Male; D008657:Metabolic Clearance Rate; D009893:Opossums / Q000378:metabolism*; D012737:Sex Factors; D014859:Warfarin / Q000097:blood / Q000493:pharmacokinetics; D015262:Xenobiotics / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D015262:Xenobiotics; D000082:Acetaminophen; D014859:Warfarin; D000983:Antipyrine