title: Lung adenocarcinoma in lymphocytic interstitial pneumonitis associated with primary Sjögren's syndrome.
abstract: We experienced a rare case of lung adenocarcinoma associated with lymphocytic interstitial pneumonitis caused by primary Sjögren's syndrome. A 78-year-old woman was referred to our hospital because of progressive sicca syndrome and nodular opacities in the right lower lobe on chest radiograph. This patient was diagnosed as primary Sjögren's syndrome by a labial gland biopsy and classical clinical features including xerophthalmia, xerostomia and immunoserological findings. Pathological findings including immunohistochemical studies in a surgically resected lung revealed adenocarcinoma in lymphocytic interstitial pneumonitis associated with primary Sjögren's syndrome. There was no evidence of malignant lymphoma in the lymph nodes or resected lung tissue. Pulmonary involvement of Sjögren's syndrome is now regarded both clinically and histopathologically as a wide spectrum of lymphoproliferative disorders ranging from benign to malignant. However, lung cancer associated with primary Sjögren's syndrome, as in our case, has apparently not been reported previously.
authors.affiliation: Department of Pulmonary Medicine, Tohoku Central Hospital, Yamagata, Japan. takabatake@mtb.biglobe.ne.jp
authors.forename: N
authors.initials: N
authors.lastname: Takabatake
authors.forename: T
authors.initials: T
authors.lastname: Sayama
authors.forename: K
authors.initials: K
authors.lastname: Shida
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Tomoike
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D011013:Pneumonectomy; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed