title: [Linkage of a porcine esterase D locus with a lethal factor].
abstract: This work is devoted to a linkage study of the gene controlling esterase D and a lethal factor in domestic pig. Segregation for two alleles EsDB, which originated from populations of miniature swine and pigs of a large white breed, and the effect of these variants on the number of offspring in a litter were compared. The results showed a linkage of locus EsD with a lethal factor. This lethal factor causes the mortality of homozygotes and half of the heterozygotes in a litter, which depends on the litter size. The lethal factor was found to be absent in miniature pigs, and in the large white breed it is predominantly linked with allele EsDB. The effect of the lethal factor on population structure and fecundity is discussed.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: G V
authors.initials: GV
authors.lastname: Orlova
authors.forename: S V
authors.initials: SV
authors.lastname: Nikitin
authors.forename: V A
authors.initials: VA
authors.lastname: Bekenev
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Lobkov
mesh_terms: D000483:Alleles; D000818:Animals; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D005804:Genes, Lethal; D008040:Genetic Linkage; D006579:Heterozygote; D006720:Homozygote; D013552:Swine / Q000235:genetics*
chemical_list: D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; C020118:ESD protein, human
vernacular_title: Stseplenie lokusa ésterase D svin'i s letal'nym faktorom.