Cell cycle genes in chondrocyte proliferation and differentiation.
Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell cycle proteins play an important role in the coordination of chondrocyte proliferation and differentiation. Our current knowledge of the function and regulation of cell cycle proteins in endochondral ossification is summarized.
Beier
F
F
Department of Biochemistry and Molecular Biology, University of Calgary, AB, Canada.
Leask
T A
TA
Haque
S
S
Chow
C
C
Taylor
A C
AC
Lee
R J
RJ
Pestell
R G
RG
Ballock
R T
RT
LuValle
P
P
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology*; D006801:Humans; D008322:Mammals
D018797:Cell Cycle Proteins