Examination of tissue distribution of Helicobacter pylori within columnar-lined esophagus.
H. pylori may colonize columnar-lined esophagus, although an etiologic role in esophageal adenocarcinoma is unproven. H. pylori can adhere to intestinal metaplasia in the stomach. This study was designed to examine if H. pylori adheres to specialized intestinal metaplasia in columnar-lined esophagus. Esophageal biopsies from patients with columnar-lined esophagus were reviewed. Patients with only gastric metaplasia were excluded. Sections with specialized intestinal metaplasia in at least one third of at least one gland were recut, stained using the Giemsa stain, and reexamined by two independent pathologists using strict criteria for adherence by H. pylori. The 209 esophageal biopsies with adequate specialized intestinal metaplasia from 58 patients were examined: H. pylori was only seen on gastric metaplasia in three patients-and never on specialized intestinal metaplasia. Within the esophagus, H. pylori adheres only to gastric metaplasia, which is not considered premalignant for esophageal adenocarcinoma.
Sharma
V K
VK
Department of Pathology, University of South Carolina, Columbia, USA.
Demian
S E
SE
Taillon
D
D
Vasudeva
R
R
Howden
C W
CW
D000230:Adenocarcinoma / Q000382:microbiology / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D004938:Esophageal Neoplasms / Q000382:microbiology / Q000473:pathology; D004947:Esophagus / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007422:Intestines / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D011230:Precancerous Conditions / Q000382:microbiology / Q000473:pathology; D013270:Stomach / Q000473:pathology