Liquid phase synthesis of arylamines and its application to the benzimidazolone via nucleophilic aryl substitution.
A method for soluble, inexpensive polymer-supported synthesis of aryl amines and benzimidazolone on the basis of nucleophilic aryl substitution (S(N)Ar) is described. This method involves a direct coupling reaction between resin bound aryl fluoride and amines at ambient temperature. The products are isolated in quantitative yields and excellent purity by simple precipitation and washing. This liquid phase method proves to be a useful tool for constructing combinatorial arylamine and benzimidazolone libraries.
Pan
P C
PC
Department of Chemistry, National Dong Hwa University, Hualien, Taiwan.
Sun
C M
CM
D000588:Amines / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry*; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D019151:Peptide Library
D000588:Amines; D001562:Benzimidazoles; D019151:Peptide Library; C014353:benzimidazolone