Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone.
Male A/J strain mice were fed AIN-76A diet supplemented with myo-inositol/dexamethasone (10 g and 0.5 mg/kg diet) or acetylsalicylic acid (300 mg/kg) and exposed for 5 months to a mixture of sidestream and mainstream cigarette smoke at a concentration of 132 mg total suspended particulates/m3. After tobacco smoke exposure, they were allowed to recover for another 4 months in filtered air. In the animals fed AIN-75A diet alone or acetylsalicylic acid, the average number of tumors/lung was 2.1, whereas in the animals given the myo-inositol/dexamethasone diet, the average lung tumor multiplicity was 1.0 (P < 0.05). In animals exposed to filtered air, lung tumor multiplicities were 0.6 for animals fed AIN-76A or myo-inositol/dexamethasone and 1.2 for animals fed acetylsalicylic acid. It was concluded that the combination of myo-inositol and dexamethasone constitutes an effective chemopreventive regimen against tobacco smoke-induced lung tumorigenesis.
Witschi
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Institute of Toxicology and Environmental Health and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Espiritu
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Uyeminami
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D001273:Atmosphere Exposure Chambers; D001835:Body Weight / Q000187:drug effects; D018890:Chemoprevention; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D019587:Dietary Supplements; D007294:Inositol / Q000008:administration & dosage / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010947:Plants, Toxic; D012906:Smoke / Q000009:adverse effects*; D013997:Time Factors; D014026:Nicotiana / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D012906:Smoke; D007294:Inositol; D003907:Dexamethasone; D001241:Aspirin