A re-appraisal of the post-testicular action and toxicity of chlorinated antifertility compounds.
Some 30 years ago, alpha-chlorohydrin and some analogues were considered as close to the ideal contraceptive which acted rapidly and reversibly on the post-testicular maturation of spermatozoa. Despite their early promise, research funding was withdrawn only 5 years later because of what were considered to be unacceptable side-effects in primates. The literature on the toxic effects of these contraceptive agents was reviewed and was found to be wanting in respect to the rigour of scientific methods applied (impure compounds were used, inappropriate target populations were studied, excessive doses were employed, abstracts were cited from which no full publications subsequently arose). These compounds remain the closest approach yet to non-hormonal contraceptives for males and have led to the synthesis of related compounds which have a similar antifertility action but with much diminished toxicity. If toxicity remains a problem, a range of other compounds now known to have a similar antifertility action, should be investigated.
Jones
A R
AR
Department of Biochemistry, University of Sydney, NSW, Australia.
Cooper
T G
TG
D000818:Animals; D003272:Contraceptive Agents, Male / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D000517:alpha-Chlorohydrin / Q000737:chemistry / Q000633:toxicity*
D003272:Contraceptive Agents, Male; D000517:alpha-Chlorohydrin