Towards a molecular understanding of arthritis.
Several different agents including free radicals, oxidizing compounds and proteases are believed to play a role in the onset of arthritis. The evidence and underlying chemistry presently available for each destructive agent are presented.
Flugge
L A
LA
Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, IL 61801, USA.
Miller-Deist
L A
LA
Petillo
P A
PA
D053674:Aggrecans; D001168:Arthritis / Q000209:etiology* / Q000378:metabolism; D002240:Carbohydrate Sequence; D002356:Cartilage / Q000378:metabolism; D016326:Extracellular Matrix Proteins; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000378:metabolism; D037181:Lectins, C-Type; D008666:Metalloendopeptidases / Q000378:metabolism; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000378:metabolism; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism
D053674:Aggrecans; D016326:Extracellular Matrix Proteins; D005609:Free Radicals; D037181:Lectins, C-Type; D011509:Proteoglycans; D009569:Nitric Oxide; D006820:Hyaluronic Acid; D008666:Metalloendopeptidases