[Stimulus-dependent effects of the sodium channel blockers in the C-fiber sensory units].
The data obtained suggest a use-dependent inhibition in the skin terminals of the C-fibre sensory units. The terminals are discussed in respect to search of efficient local anaesthetising agents as well as cardiac anti-arrhythmic agents with obvious neurotropic effects.
Revenko
S V
SV
Cardiological Research Centre, Moscow, Russia.
Borovikova
L V
LV
Ermishkin
V V
VV
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D006358:Hot Temperature; D008012:Lidocaine / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D010812:Physical Stimulation; D011219:Prajmaline / Q000494:pharmacology; D012867:Skin / Q000294:innervation*; D015222:Sodium Channels / Q000187:drug effects*; D014110:Touch
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D015222:Sodium Channels; D011219:Prajmaline; D008012:Lidocaine
Stimulozavisimye éffekty pri deĭstvii blokatorov natrievykh kanalov na sensornye C-edinitsy.