Correlation of biochemical tumor markers with conventional pathological features in primary breast cancer.
In this prospective study the correlation of pathological with biological prognostic factors and serum tumor markers has been investigated in 574 patients with primary invasive breast cancer. The p53 protein and Bax level correlated positively with tumor size, lymph node status and histological grade. The serum levels of CEA, CA 15.3, TPA-M and TK correlated with tumor extent. There was a significant difference between pre- and postmenopausal breast cancer patients in serum levels of TPA-M and cytosol levels of Bax. Whether these correlations can help in predicting the prognosis of breast cancer by providing additional information with respect to the conventional factors, will have to be investigated by several years of careful clinical follow-up.
Péley
G
G
Department of Surgery, National Institute of Oncology, Budapest, Hungary.
Bezzegh
A
A
Besznyák
I
I
Doleschall
Z
Z
Csuka
O
O
Péter
I
I
Tóth
J
J
Számel
I
I
Schumann
B
B
Ottó
S
S
D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D006801:Humans; D018396:Mucin-1 / Q000097:blood; D011446:Prospective Studies; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood; D013937:Thymidine Kinase / Q000097:blood; D019396:Tissue Polypeptide Antigen / Q000097:blood; D016159:Tumor Suppressor Protein p53 / Q000097:blood
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D019253:Proto-Oncogene Proteins c-bcl-2; D019396:Tissue Polypeptide Antigen; D016159:Tumor Suppressor Protein p53; D013937:Thymidine Kinase