Rhabdomyolysis in association with Duchenne's muscular dystrophy.
OBJECTIVE
To present a case of rhabdomyolysis which developed in a child with a known history of Duchenne's muscular dystrophy, following an anesthetic which included sevoflurane.


METHODS
An 11 yr old boy with a known history of Duchenne's muscular dystrophy underwent anesthesia for strabismus repair. The anesthetic consisted of sevoflurane and nitrous oxide without the use of a muscle relaxant. His postoperative course was complicated by a complaint of heel pain and the development of myoglobinuria. He was treated with dantrolene sodium and discharged home after two days, without further complication.


CONCLUSIONS
Sevoflurane anesthesia has not been shown previously to be associated with the development of acute rhabdomyolysis in a child with a history of Duchenne's muscular dystrophy. As with halothane and isoflurane, the continued use of sevoflurane in the presence of Duchenne's muscular dystrophy should be questioned.
Obata
R
R
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
Yasumi
Y
Y
Suzuki
A
A
Nakajima
Y
Y
Sato
S
S
D000208:Acute Disease; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D003620:Dantrolene / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000009:adverse effects*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D009136:Muscular Dystrophies / Q000150:complications* / Q000503:physiopathology; D009212:Myoglobinuria / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology; D009609:Nitrous Oxide / Q000008:administration & dosage; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D000077149:Sevoflurane; D013285:Strabismus / Q000601:surgery
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D009125:Muscle Relaxants, Central; D000077149:Sevoflurane; D003620:Dantrolene; D009609:Nitrous Oxide