Brain noradrenergic receptors in major depression and schizophrenia.
The binding of [125I]p-iodoclonidine to alpha-2, and/or [125I]iodopindolol to beta-1 and beta-2 adrenoceptors was measured in right prefrontal cortex (Brodmann's area 10) and right hippocampus from subjects with DSM-III-R diagnoses of major depression (n = 15) or schizophrenia (n = 8) as well as from control subjects (n = 20). No significant differences between study groups were observed in binding to alpha-2 adrenoceptors in any of the six layers of prefrontal cortex or in any of the hippocampal fields. Likewise, there were no significant differences in beta-1 or beta-2 adrenoceptor binding in any of the hippocampal fields between control and major depressive subjects. In contrast, binding to beta-1 adrenoceptors, but not beta-2 adrenoceptors, was significantly lower (-13 to -27%) in most hippocampal fields of schizophrenic subjects as compared to control subjects or to major depressives. Alterations in beta-1 adrenoceptor binding in the hippocampus of schizophrenics provide further evidence for a role of central noradrenergic neurons in the neurochemical pathology of schizophrenia.
Klimek
V
V
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Rajkowska
G
G
Luker
S N
SN
Dilley
G
G
Meltzer
H Y
HY
Overholser
J C
JC
Stockmeier
C A
CA
Ordway
G A
GA
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D000328:Adult; D000345:Affinity Labels; D000368:Aged; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology*; D003000:Clonidine / Q000031:analogs & derivatives; D003866:Depressive Disorder / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism*; D010869:Pindolol / Q000031:analogs & derivatives; D017397:Prefrontal Cortex / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D013405:Suicide
D000316:Adrenergic alpha-Agonists; D000319:Adrenergic beta-Antagonists; D000345:Affinity Labels; D007457:Iodine Radioisotopes; D011941:Receptors, Adrenergic; C053113:4-iodoclonidine; C029247:3-iodopindolol; D010869:Pindolol; D003000:Clonidine; D009638:Norepinephrine