title: What have we learned from gene targeting studies for the renin angiotensin system of the kidney?
abstract: Over the last decade, gene targeting technologies have provided investigators with powerful new tools to study the physiology and pathophysiology of the kidney. In that, the renin-angiotensin system (RAS) has been a subject of intense investigation. Detailed analyses of mutant mice have not only confirmed notions already suggested by other studies, but also shed a new light on previously unrecognized functions of RAS. In this review, we will focus on what we have learned from these gene targeted animals in particular relevance to nephrology.
authors.affiliation: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232-2584, USA.
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: I
authors.initials: I
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D018390:Gene Targeting / Q000379:methods*; D007668:Kidney / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology; D051379:Mice; D008817:Mice, Mutant Strains; D012084:Renin-Angiotensin System / Q000502:physiology*