Acute lymphoblastic leukemia with multiple cytogenetic abnormalities secondary to treatment of Ewing's sarcoma.
We report the case of a 22-year-old man with Ewing's sarcoma who attained a complete remission (CR) after combination radiotherapy and chemotherapy. Secondary acute lymphoblastic leukemia with multiple cytogenetic abnormalities involving chromosome 5 and 7 developed 16 years later. The patient underwent induction chemotherapy and entered a CR. Peripheral blood stem cell transplantation from a matched sibling was performed successfully and he is in complete remission of both ALL and Ewing's sarcoma.
Al-Homaidhi
A M
AM
Department of Medicine, Princess Margaret Hospital and The University of Toronto, Ont., Canada.
Patterson
B
B
Rubin
S
S
Lipton
J H
JH
D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects; D012512:Sarcoma, Ewing / Q000235:genetics*
D018906:Antineoplastic Agents, Alkylating