Migratory potential of transplantable neural tumor cell lines.
Experimentally induced primitive neuroectodermal tumor (PNET) cell lines were transplanted into neonatal and adult rat brain and examined neuropathologically for their tumorigenic potential. Both cell lines showed a striking migratory behavior in both neonatal and adult brain. Migration of tumor cells was found in host brain parenchyma, along white matter tracts and associated with CSF pathways. These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors.
Bayer
T A
TA
Department of Psychiatry, University of Bonn Medical Center, Germany. bayer@uni-bonn.de
Thier
M
M
Roeb
E
E
Breuer
B
B
Weggen
S
S
Wiestler
O D
OD
Weis
J
J
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology*; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D051381:Rats; D019737:Transplants; D014407:Tumor Cells, Cultured
D020778:Matrix Metalloproteinase 2