Synthesis and antibacterial activity of 2-aryl-2,5-dihydro-3(3H)-oxo-pyridazino[4,3-b]indole-4-carboxylic acids.
The in vitro antibacterial and antifungal activities of a series of pyridazinoindolonic acids II against some selected representative of Gram-positive, Gram-negative bacteria and fungi have been investigated. Some interesting observations among the structural features necessary for high antibacterial activity are presented and discussed.
Palluotto
F
F
Dipartimento Farmacochimico, Università di Bari, Italy.
Carotti
A
A
Casini
G
G
Ferappi
M
M
Rosato
A
A
Vitali
C
C
Campagna
F
F
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007211:Indoles; D011724:Pyridazines