Cytotoxic T lymphocyte activation by cross-priming.
Cross-priming represents the induction of cytotoxic T lymphocyte responses to exogenous, usually cell associated, antigens that are captured and re-presented on bone-marrow-derived antigen-presenting cells. For effective cross-priming, cytotoxic T lymphocytes require help from CD4(+) T cells, which mediate this help indirectly via modification of the antigen-presenting cell. Recent advances made in research into the cellular and molecular interactions required for cross-priming have greatly improved our understanding of the antigenic requirements for effective priming and have revealed a role for CD40 and its ligand in the provision of T cell help.
Heath
W R
WR
The Immunology Division, The Walter and Eliza Hall Institute of MedicalResearch, Parkville, Victoria, 3050, Australia. Heath@wehi.edu.au
Carbone
F R
FR
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D019013:CD40 Antigens