Growth hormone treatment in a child with Williams-Beuren syndrome: a case report.
Growth retardation is a consistent finding in Williams-Beuren syndrome. The cause of short stature in this syndrome is unknown. Endocrine studies have failed to reveal abnormalities in the growth hormone-insulin-like growth factor I axis. We report a boy with confirmed Williams-Beuren syndrome, who was found to have classical growth hormone deficiency and responded well to growth hormone therapy.


CONCLUSIONS
Although growth hormone deficiency is not likely to be a common cause of short stature in Williams-Beuren syndrome, we nevertheless recommend evaluation of the growth hormone-insulin-like growth factor I axis in all cases.
Kuijpers
G M
GM
Department of Endocrinology, Wilhelmina Children's Hospital, Utrecht University, The Netherlands. g.kuijpers@wkz.azu.nl
De Vroede
M
M
Knol
H E
HE
Jansen
M
M
D002675:Child, Preschool; D006130:Growth Disorders / Q000188:drug therapy / Q000209:etiology*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D018980:Williams Syndrome / Q000175:diagnosis / Q000503:physiopathology*
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I