Childhood immunobullous disease following a second organ transplant.
Immunobullous diseases are quite unusual in children. We report two children who developed immunobullous disease shortly after a second solid organ transplantation. One child had IgA pemphigus vegetans, the other bullous pemphigoid. We hypothesize that the repeat organ transplantation served as a "booster" immunization for autoantibody production. Both children developed their immunobullous condition while being treated with immunosuppressive drugs that are used to treat immunobullous disorders.
Morelli
J G
JG
Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado 80262, USA. joseph.morelli@UCHSC.edu
Weston
W L
WL
D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D016377:Organ Transplantation; D010391:Pemphigoid, Bullous / Q000209:etiology; D010392:Pemphigus / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology; D012872:Skin Diseases, Vesiculobullous / Q000209:etiology*
D007166:Immunosuppressive Agents