[The role of nitric oxide and blood platelets in pathogenesis of preeclampsia].
The aim of this study was to evaluate the concentration of nitric oxide and the platelet function in preeclamptic and normal pregnant women. The patients with preeclampsia had new hypertension (diastolic blood pressure consistently > or = 90 mmHg with previously lower readings), new proteinuria and generalized oedema that subsequently regressed after delivery. Blood was collected by routine forearm venipuncture before delivery. The following parameters were evaluated: nitric oxide, beta-TG and PF4. The nitric oxide plasma concentration in women with preeclampsia was significantly lower compared with normotensive pregnant women. beta-TG and PF4 concentrations were significantly increased in patients with preeclampsia. Whether these observations contribute to the vascular pathophysiologic features of preeclampsia remains to be proved.
Bielecki
M
M
Kliniki Połoznictwa Instytutu Połoznictwa i Chorób Kobiecych AM w Białymstoku.
Zdrodowska
J
J
Bodzenta-Lukaszyk
A
A
Tomasiak
M
M
Jarocki
S
S
Bielecki
D A
DA
D000328:Adult; D001792:Blood Platelets / Q000737:chemistry*; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D009569:Nitric Oxide
Rola tlenku azotu (NO) i płytek krwi w patogenezie EPH gestozy.