Common slow modulation of respiration, arterial blood pressure and cortical activity during sleep onset while napping.
Using healthy subjects, concomitant 30- to 60-s modulations of respiration, arterial blood pressure and EEG activity were found in 21 experiments about napping. Although mean arterial pressure (MAP) modulations above and below 1/30 Hz increased, in respiratory amplitude (RA) only the lower frequency components augmented significantly. This slow modulation of RA was found to be asymmetrical in time, the duration of RA decreasing parts in the modulation waves being 42% longer than the duration of RA increasing parts. The concomitance of the slow modulations in the different organ systems is accounted for by the influence of the common brainstem system (CBS), which regulates and integrates respiratory, cardiovascular and somatomotor systems and the adjustment of central nervous activity (vigilance). The described common, slow modulations outline the importance of dampening influences during sleep onset. They may provide an important tool for the investigation of the regulatory systems during sleep onset, as well as for investigations about sleep apnoea syndrome and Cheyne-Stokes breathing.
Rittweger
J
J
Institut für Physiologie, Freie Universität Berlin, Germany.
D000328:Adult; D001143:Arousal / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D012119:Respiration; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology