Cryptic Mucor infection leading to massive cerebral infarction at initiation of antileukemic chemotherapy.
A 74-year-old man with newly diagnosed acute myelogenous leukemia unexpectedly suffered a massive cerebral infarct on day 2 of induction chemotherapy. Clinically, the hemorrhagic infarct was thought to be due to leukostasis and thrombocytopenia. Necropsy, however, revealed that Zygomycetes-type hyphae had infiltrated cerebral vessels in and near the infarct. The fungal infection was clinically silent otherwise, although fungal elements were also identified in the lung at autopsy. This case illustrates how closely fungal infection may resemble a leukemia-associated cerebrovascular accident.
Mathur
S C
SC
SUNY Health Science Center, Syracuse NY, USA.
Friedman
H D
HD
Kende
A I
AI
Davis
R L
RL
Graziano
S L
SL
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D002490:Central Nervous System / Q000382:microbiology; D002544:Cerebral Infarction / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008168:Lung / Q000382:microbiology; D008297:Male; D009091:Mucormycosis / Q000150:complications*
D000970:Antineoplastic Agents