[Interferon inducers: new generation of immunomodulators].
Interferon (IFN) inducers are the agents having a wide range of antiviral activity. They have not only etiotropic, but marked immunomodulating effects. INF inducers different in its nature cause IFN synthesis in different immunocytic populations. The kinetics of the production of IFN and their antigenic composition depend on the chemical structure of an inducer and on their stimulated target cell populations. Their capacity of stimulating the synthesis of IFN in these or those organs determines the spectrum of application of an inducer and the time course of serum IFN accumulation--the strategy of its use. IFN inducers have a number of advantages over exogenous IFN. They stimulate the synthesis of the body's own IFN, which has no antigenicity unlike the most widely used recombinant IFN. IFN inducers cause IFN circulation at the therapeutical levels, at the same time to achieve such an effect requires multiple administration of large-dose exogenous agents. Some IFN inducers includes IFN synthesis in particular cell populations and organs, which has certain advantages over the polyclonal stimulation of IFN immunocytes. IFN inducers are well combined with IFN and other antiviral agents. The combination of these properties leads to the conclusion that IFN inducers are a highly promising group of agents having both etiotropic and immunomodulating effects.
Ershov
F I
FI
Tazulakhova
E B
EB
D000276:Adjuvants, Immunologic; D000818:Animals; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis / Q000187:drug effects; D014777:Virus Diseases / Q000276:immunology / Q000378:metabolism / Q000628:therapy
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D007372:Interferons
Induktory interferona - novoe pokolenie immunomoduliatorov.