Cytokine/chemokine cascades in immunity to tuberculosis.
The relationship between acquired specific resistance and delayed-type hypersensitivity (DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and Andrea Cooper propose that the events are separate mechanisms; protection is cytokine driven and initially controls the infection, whereas DTH is primarily chemokine driven and functions to wall off the infection and prevent further dissemination.
Orme
I M
IM
Mycobacteria Research Laboratories, Dept of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
Cooper
A M
AM
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D008168:Lung / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D018925:Chemokines; D016207:Cytokines