title: Suberythemogenic narrow-band UVB is markedly more effective than conventional UVB in treatment of psoriasis vulgaris.
abstract: BACKGROUND
  Narrow-band UVB (NB-UVB) is a new phototherapy option for psoriasis. Action spectrum studies previously done with different UVB wavelengths suggest that suberythemogenic doses of NB-UVB could be highly effective in treating psoriasis vulgaris. Even so, no comparative studies with suberythemogenic doses of NB versus conventional UVB have been performed previously.
  
  
  OBJECTIVE
  Our purpose was to compare conventional broad-band UVB (BB-UVB) with NB-UVB at suberythemogenic doses for the treatment of psoriasis vulgaris.
  
  
  METHODS
  Eleven patients were treated using a split-body approach for 6 weeks on a three-times-a-week basis. Outcomes were evaluated by means of Psoriasis Severity Index scores and quantitative histologic measures.
  
  
  RESULTS
  We were able to induce clinical clearing in 81.8% of patients after NB-UVB, but in only 9.1% of patients after BB-UVB (P < .01). Biopsy specimens obtained at the end of treatment revealed that keratin 16 staining was absent in 75% of patients on the NB side compared with none on the BB side, suggesting a reversal of regenerative epidermal hyperplasia by NB-UVB.
  
  
  CONCLUSIONS
  NB-UVB is superior to UVB-BB in reversing psoriasis at suberythemogenic doses when given three times per week. This schedule was well tolerated by all patients.
authors.affiliation: Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York 10021-6399, USA.
authors.forename: I B
authors.initials: IB
authors.lastname: Walters
authors.forename: L H
authors.initials: LH
authors.lastname: Burack
authors.forename: T R
authors.initials: TR
authors.lastname: Coven
authors.forename: P
authors.initials: P
authors.lastname: Gilleaudeau
authors.forename: J G
authors.initials: JG
authors.lastname: Krueger
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000473:pathology / Q000532:radiotherapy*; D014467:Ultraviolet Therapy / Q000379:methods