[Involvement of neurotrophic factors in central mechanisms of behavior in adult animals].
The effect of antibodies against some neurotrophic factors (S-100b protein, CSL, etc.) on elaboration, storage, and retrieval of acoustic startle habituation and concomitant freezing behaviour, was found to be dose-dependent in adult rats. Thus, the 5-mcg dose impaired the consolidation and/or storage process, whereas 2 mcg only impaired the storage of long-term acoustic startle habituation, and 0.5 mcg exerted no effect at all. The habits retrieval displayed no dependence on the antibodies effect.
Sherstnev
V V
VV
P. K. Anokhin Institute of Normal Physiology, Moscow, Russia.
Storozheva
Z I
ZI
Gruden'
M A
MA
Proshin
A T
AT
D000161:Acoustic Stimulation; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D003674:Defense Mechanisms; D037102:Lectins / Q000276:immunology / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000502:physiology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology / Q000502:physiology*
D000906:Antibodies; D037102:Lectins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
Uchastie neĭrotroficheskikh faktorov v tsentral'nykh mekhanizmakh povedeniia u vzroslykh zhivotnykh.