title: [Examination of the stability of chloral hydrate and its preparation by capillary electrophoresis].
abstract: Stabilities of chloral hydrate in an aqueous solution and its medicated syrup were examined by high performance capillary electrophoresis. Analysis of the concentration of chloral hydrate indicated that there was no obvious change in the concentration of chloral hydrate both in the aqueous solution and in the syrup preparation after keeping them for 3 months at room temperature or at 60 degrees C. The lowering of pH was more obvious in the syrup solution than in the aqueous solution, and this tendency was estimated to be due to the formation of hydrochloric acid. We propose that the stabilities of the preparation of chloral hydrate should be monitored by observing pH changes.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kakehi
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: S
authors.initials: S
authors.lastname: Nishiura
authors.forename: S
authors.initials: S
authors.lastname: Tachibana
authors.forename: S
authors.initials: S
authors.lastname: Ishida
authors.forename: M
authors.initials: M
authors.lastname: Taneda
mesh_terms: D002697:Chloral Hydrate / Q000032:analysis; D004304:Dosage Forms; D004355:Drug Stability; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration
chemical_list: D004304:Dosage Forms; D002697:Chloral Hydrate