[Fronto-temporal degenerative dementia. A modern neuropathologic approach].
The classification of degenerative dementias with fronto-temporal atrophy has been debated since the description of Pick's disease. The study of a clinico-pathological series of 10 cases using immunohistochemistry lead to the following conclusions: reserving the name of Pick's disease to those cases with argyrophilic inclusions, the most recognisable and characteristic marker at neuropathological examination, allows an easy and reliable diagnosis; keeping on with the splitting of these disorders into various clinico-pathologic entities seems today more useful than grouping them into a single syndrome until new data, based for example on genetic analysis, show that different phenotypes correspond to the same disease.
Hauw
J J
JJ
Laboratoire de Neuropathologie R. Escourolle, Université Pierre et Marie Curie (Paris VI), INSERM U 360, Association Claude Bernard, Hôpital de la Salpêtrière, Paris.
Duyckaerts
C
C
Seilhean
D
D
Hogenhuis
J
J
Suarez
S
S
Sazdovitch
V
V
Rancurel
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology*; D012189:Retrospective Studies; D013702:Temporal Lobe / Q000473:pathology*
Les démences dégénératives fronto-temporales. Une approche neuropathologique moderne.