[Toxicity and radiation protective properties of 2(3)-guanidinoalkanethiols: structure-activity].
In experiments with mice radioprotective properties and toxicity of 2(3)-guanidinoalkanethiols were investigated by exposure to gamma-irradiation in the dose of 6.4 Gy. The obtained results allow to find an association between radioprotective activity of 2(3)-guanidinoalkanethiol compounds and their structure and toxicity.
Mandrugin
A A
AA
Moscow State University, Department of Chemistry. mandrug@radio.chem.msu.ru
Fedoseev
V M
VM
Dubovaia
O V
OV
Rodiunin
A A
AA
Konstantinova
M M
MM
Dontsova
G V
GV
D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D007928:Lethal Dose 50; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship
D006146:Guanidines; D011837:Radiation-Protective Agents
Toksichnost' i protivoluchevye svoĭstva 2(3)-guanidinoalkantiolov: struktura-aktivnost'.