title: [Scleroderma--systemic sclerosis. Serology, lung function and survival].
abstract: Patients with systemic sclerosis (SSc) were studied with regard to the presence of antinuclear antibodies (ANA) and their clinical correlates (n = 230), pulmonary function (n = 176), and mortality and causes of death (n = 344). ANA were found in 85%. Anti-centromere antibodies were found in 34%, anti-Scl-70 antibodies in 13% and anti-U1-RNP antibodies in 6.5%. These serological groups were associated with limited SSc, diffuse SSc, and myositis/arthritis, respectively. The most prevalent finding at first lung function test was isolated reduction of diffusion capacity (47%). Further deterioration of diffusion capacity was related to the presence of anti-centromere antibodies and increased sedimentation rate. The standardized mortality rate (SMR) was 2.9, higher in young patients (SMR = 13) and patients with diffuse SSc (SMR = 4.5).
authors.affiliation: Dermatologisk afdeling, H:S Bispebjerg Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Ullman
authors.forename: P
authors.initials: P
authors.lastname: Halberg
authors.forename: A
authors.initials: A
authors.lastname: Wiik
authors.forename: S
authors.initials: S
authors.lastname: Jacobsen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001799:Blood Sedimentation; D002423:Cause of Death; D002503:Centromere / Q000276:immunology; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012595:Scleroderma, Systemic / Q000276:immunology / Q000401:mortality / Q000503:physiopathology; D015996:Survival Rate
chemical_list: D000974:Antibodies, Antinuclear
vernacular_title: Sklerodermi--systemisk sklerose. Serologi, lungefunktion og overlevelse.