title: Reducing catheter-associated infections with silver-impregnated catheters in long-term therapy of children.
abstract: Central venous long-term catheters offer reliable, large-lumen vascular access with high flow rates for delivery of nutrition or for cell-containing infusions and perfusions. Catheter-associated infections (CAI) pose the greatest threat to such vascular access, despite existing preventive measures. In this article one prospective and one retrospective study of CAI in pediatric therapy are presented. Study I: A retrospective investigation from 1990 through 1995 of 60 conventional long-term catheters in 50 patients. The total number of days in which the catheters were in place was 11,818. The calculated CAI incidence was 1 per 1,000 days of catheter insertion. Bacteriologically demonstrated CAI (identical isolate on the catheter tip and in a blood culture) occurred in three instances (5%). Five cases (8.3%) were diagnosed with a therapy-resistant, septic clinical picture. Study II: A prospective, randomized comparison of long-term silver-impregnated (Erlanger silver catheters) and control catheters (Quinton Instrument Co.) was made with 41 patients (20 with a silver catheter, 21 with a Quinton catheter). To date, the silver catheters have been distinguished by sterile bacteriological findings, whereas three cases of CAI have been demonstrated with the comparative catheters. One patient recently underwent intensive care after becoming unstable with signs of septic shock and demonstrable Pseudomonas aeruginosa, and two other patients manifested coagulase-negative staphylococci on the catheter tips. In three of nine control catheters an incidence of 1.18 per 1,000 days of indwelling catheters was found, whereas no CAI has occurred with the eight microbiologically tested silver catheters.
authors.affiliation: Abt. für Kinderchirurgie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
authors.forename: R T
authors.initials: RT
authors.lastname: Carbon
authors.forename: S
authors.initials: S
authors.lastname: Lugauer
authors.forename: U
authors.initials: U
authors.lastname: Geitner
authors.forename: A
authors.initials: A
authors.lastname: Regenfus
authors.forename: M
authors.initials: M
authors.lastname: Böswald
authors.forename: J
authors.initials: J
authors.lastname: Greil
authors.forename: T
authors.initials: T
authors.lastname: Bechert
authors.forename: S I
authors.initials: SI
authors.lastname: Simon
authors.forename: H P
authors.initials: HP
authors.lastname: Hümmer
authors.forename: J P
authors.initials: JP
authors.lastname: Guggenbichler
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011446:Prospective Studies; D012189:Retrospective Studies; D012834:Silver / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D012834:Silver