The toxicology of interleukin-12: a review.
Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial activities and can modify allergic inflammatory reactions in animal models. Recombinant human IL-12 (rhIL-12) is currently in clinical trials for treatment of cancer, asthma, and viral hepatitis. Principally a phagocyte-derived cytokine, IL-12 targets natural killer cells and T lymphocytes, stimulating their activity and the secretion of interferon (IFN)-gamma. An understanding of the toxicology of IL-12, due in part to effects mediated by IFN-gamma, has emerged from preclinical safety and mechanistic studies and initial clinical trials. Target organs common to several animal species and humans include the lymphohematopoietic system, intestines, liver, and lung.
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Safety Assessment, DuPont Pharmaceuticals Company, Newark, Delaware 19714-0030, USA. bruce.d.car.2@dupontpharma.com
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Lipman
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Anderson
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D000818:Animals; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D018664:Interleukin-12 / Q000633:toxicity*; D011994:Recombinant Proteins / Q000633:toxicity
D011994:Recombinant Proteins; D018664:Interleukin-12