title: Isolation and synthesis of a novel immunosuppressive 17alpha-substituted dammarane from the flour of the Palmyrah palm (Borassus flabellifer).
abstract: The novel triterpene 1 with a dammarane skeleton and a hitherto unknown 17alpha-substitution pattern has been isolated from the Palmyrah palm in low yield and prepared by synthesis in larger quantities. 1 was shown to be an extremely potent immunosuppressant in vitro (MLR; IC50 = 10 ng/ml) and in vivo (DTH; ED50 = 0.01 mg/kg p.o.). A glucocorticoid like activity is excluded.
authors.affiliation: Novartis Pharma AG, Arthritis and Bone Research, Switzerland. laszlo.revesz@pharma.novartis.com
authors.forename: L
authors.initials: L
authors.lastname: Révész
authors.forename: P
authors.initials: P
authors.lastname: Hiestand
authors.forename: L
authors.initials: L
authors.lastname: La Vecchia
authors.forename: R
authors.initials: R
authors.lastname: Naef
authors.forename: H U
authors.initials: HU
authors.lastname: Naegeli
authors.forename: L
authors.initials: L
authors.lastname: Oberer
authors.forename: H J
authors.initials: HJ
authors.lastname: Roth
mesh_terms: D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D008214:Lymphocytes / Q000187:drug effects; D008956:Models, Chemical; D010940:Plant Proteins / Q000138:chemical synthesis* / Q000302:isolation & purification*; D014315:Triterpenes / Q000138:chemical synthesis* / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured
chemical_list: D007166:Immunosuppressive Agents; D010940:Plant Proteins; D014315:Triterpenes