Urinary gonadotropin peptide as acute phase reactant: transient elevation after operation for digestive diseases.
OBJECTIVE
In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation.


METHODS
Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study.


METHODS
UGP levels were measured using an enzyme immunoassay before and after surgery.


RESULTS
Fifty-four (80.6%) of the 67 cases studied showed transient elevations of UGP. Both urinary interleukin (IL)-6 and LH levels were also increased transiently in 49 cases (73.1%). All of these three factors were increased in 38 cases (56.7%), and in 32 (84.2%) of these 38 cases, the order of peak appearance was as follows: IL-6, LH, and UGP. The UGP levels in the group of total gastrectomy were significantly higher than those in the group of partial gastrectomy.


CONCLUSIONS
These results suggest that UGP shows a transient peak after surgery, correlating with levels of cytokines such as IL-6. UGP may be an acute phase reactant, and its levels are correlated with the grade of surgical stress.
Motoo
Y
Y
Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.
Watanabe
H
H
Okai
T
T
Sawabu
N
N
D000210:Acute-Phase Reaction / Q000652:urine*; D000328:Adult; D000368:Aged; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000652:urine*; D005260:Female; D005743:Gastrectomy; D005767:Gastrointestinal Diseases / Q000601:surgery* / Q000652:urine; D005770:Gastrointestinal Neoplasms / Q000601:surgery; D006801:Humans; D015850:Interleukin-6 / Q000652:urine; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000652:urine*; D011182:Postoperative Care; D011300:Preoperative Care
D018997:Chorionic Gonadotropin, beta Subunit, Human; D015850:Interleukin-6; D010446:Peptide Fragments; C063554:urinary gonadotropin fragment; D007986:Luteinizing Hormone