title: [Evaluation of radioprotective properties of a lipocarotenoid extract from mycelium of basidiomycetes during external irradiation].
abstract: Radioprotective properties of LPC extract from mycelium of Basidiomycetes fungus at doses 12.0; 3.0 and 1.0 Gy of external irradiation were investigated. The extract of LPC at 2.5 mkg/ml concentration promoted the survival of animals (to 40%) and increased the average life at the lethal dose. At 1.0 Gy dose the use of extract resulted in restoration of radiosensitive organs weights, the number of blood leucocytes and some indexes of lipid peroxidation in blood plasma. The extract has produced some effect on the amount of spermatogenic cells in the testis.
authors.affiliation: Institute of Radiobiology National Academy of Sciences of Belarus, Minsk.
authors.forename: E F
authors.initials: EF
authors.lastname: Konoplia
authors.forename: A N
authors.initials: AN
authors.lastname: Kapich
authors.forename: G G
authors.initials: GG
authors.lastname: Vereshchako
authors.forename: A M
authors.initials: AM
authors.lastname: Khodosovskaia
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Rutkovskaia
authors.forename: T S
authors.initials: TS
authors.lastname: Gvozdkova
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002338:Carotenoids / Q000302:isolation & purification / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013076:Sperm Count / Q000187:drug effects / Q000528:radiation effects
chemical_list: D011837:Radiation-Protective Agents; D002338:Carotenoids; D008315:Malondialdehyde
vernacular_title: Otsenka radiozashchitnykh svoĭstv lipokarotinoidnogo ékstrakta iz mitseliia bazodial'nogo griba v usloviiakh vneshnego oblucheniia.