Transcription factors: the right combination for the DNA lock.
Recently determined structures of complexes between homeodomain proteins, their cofactors and DNA have provided new insights into the way pairs of transcription factors can collaborate to select the appropriate target DNA-binding sites during development.
Khorasanizadeh
S
S
Department of Chemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA.
Rastinejad
F
F
D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000737:chemistry / Q000378:metabolism; D046911:Macromolecular Substances; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism
D018398:Homeodomain Proteins; D046911:Macromolecular Substances; D014157:Transcription Factors; D004247:DNA