title: Hypothesis: sex determination and germline formation are committed at the pronucleate stage in mammalian embryos.
authors.affiliation: ESHRE Journals, Editorial Office, Moor Barns Farmhouse, Coton, Cambridge CB3 7PG, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Edwards
authors.forename: H K
authors.initials: HK
authors.lastname: Beard
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D008322:Mammals; D009865:Oocytes / Q000502:physiology; D019849:Sex Determination Processes; D014960:X Chromosome; D015053:Zygote / Q000502:physiology*