title: [Clinical, parasitological and histopathologic follow-up studies of acute Chagas patients treated with benznidazole].
abstract: With the purpose of studying their clinical and histopathologic evolution, 10 acute chagasic patients with myocarditis diagnosed by endomyocardial biopsy and positive sero-parasitologic methods were evaluated at 11 months (8-21 months) after treatment with oral benznidazole. Four of them were reevaluated 5 years post-treatment (58-68 months). Study protocol consisted of clinical, hemodynamic, echocardiographic, seroparasitologic and histopathologic evaluations. Results showed evidence of persisting myocarditis in 90% and 75% of patients evaluated at 11 months and 5 years respectively, along with asymptomatic, subclinical left ventricular systolic dysfunction being recognized in 75% of patients evaluated 5 years after treatment. All parasitologic studies became negative during follow-up, but serology remained positive for Trypanosoma cruzi antibodies in 80% and 75% of patients studied at 11 months and 5 years. In conclusion, myocardial damage was constantly found in our acute chagasic patients. Treatment with benznidazole eliminated symptoms and parasitemia, but it does not seem to alter favorably the histopathological evolution of the chagasic cardiac disease.
authors.affiliation: Centro de Investigaciones Cardiovasculares, Universidad de los Andes, Mérida, Venezuela.
authors.forename: I
authors.initials: I
authors.lastname: Inglessis
authors.forename: H A
authors.initials: HA
authors.lastname: Carrasco
authors.forename: N
authors.initials: N
authors.lastname: Añez
authors.forename: C
authors.initials: C
authors.lastname: Fuenmayor
authors.forename: H
authors.initials: H
authors.lastname: Parada
authors.forename: J A
authors.initials: JA
authors.lastname: Pacheco
authors.forename: H R
authors.initials: HR
authors.lastname: Carrasco
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002598:Chagas Cardiomyopathy / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D002648:Child; D004562:Electrocardiography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011817:Rabbits; D014352:Trypanosomiasis / Q000150:complications / Q000523:psychology
chemical_list: D009593:Nitroimidazoles; C009999:benzonidazole
vernacular_title: Seguimiento clínico, parasitológico e histopatológico de pacientes chagásicos agudos tratados con benznidazol.