Nutritional status and growth after bone marrow transplantation (BMT) during childhood: EBMT Late-Effects Working Party retrospective data. European Group for Blood and Marrow Transplantation.
The European Group for Blood and Marrow Transplantation (EBMT) Late-Effects Working Party collected data on patients who survived more than 5 years after BMT. Height at transplant and at the latest follow-up examination were evaluated in 79/258 subjects who were below the age of 15 at BMT. A significant decrease in height-standard deviation score (SDS) was observed in leukemic children conditioned with total body irradiation (TBI) and in those who received both cranial irradiation and TBI. The majority of these patients, however, received single-dose TBI (28/41). A significant decrease in height-SDS was also seen in children who received thoraco-abdominal irradiation suggesting that the deleterious effect of irradiation on growth after BMT is not entirely due to injury to cranial neuroendocrine structures, but also probably due to damage to bone epiphyses, thyroid and gonads. A non-significant decrease in height was observed in children transplanted using chemotherapy alone. Nutritional status, expressed as body-mass index (BMI), was found unchanged in the adult group (n = 158). A significant increase in BMI was observed in the younger patients (n = 88), which parallels the normal increase in BMI observed during childhood. This suggests that on long-term analysis, a good nutritional status is maintained in patients undergoing BMT at any age.
Cohen
A
A
University Department of Pediatrics, Gaslini Institute, Children's Hospital, Genoa, Italy.
Duell
T
T
Socié
G
G
van Lint
M T
MT
Weiss
M
M
Tichelli
A
A
Rovelli
A
A
Apperley
J F
JF
Ljungman
P
P
Kolb
H J
HJ
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000532:radiotherapy / Q000628:therapy; D015992:Body Mass Index; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005060:Europe; D005260:Female; D006128:Growth; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000532:radiotherapy / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D012189:Retrospective Studies; D011795:Surveys and Questionnaires