Effect of a new immunosuppressant, FTY720, on joint allografts.
The immunosuppressive effects of a new agent, FTY720, on joint allografts were studied histologically in a rat model. Favorable results without side effects were obtained at a dose of 3.0 mg/kg/day. The authors believe that this agent is one of the most useful immunosuppressants in the reported experimental model.
Watanabe
H
H
Department of Orthopaedic Surgery, Yamanashi Medical College, Nakakomagun, Yamanashi-Ken, Japan.
Hamada
Y
Y
Toshima
T
T
Nagasawa
K
K
Sakano
Y
Y
D000714:Anastomosis, Surgical; D000818:Animals; D004195:Disease Models, Animal; D000068876:Fingolimod Hydrochloride; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007719:Knee Joint / Q000187:drug effects* / Q000601:surgery*; D008297:Male; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D013110:Sphingosine / Q000031:analogs & derivatives; D018709:Statistics, Nonparametric; D014184:Transplantation, Homologous / Q000276:immunology; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine