title: [Two new antidepressants: mirtazapine and venlafaxine].
abstract: Mirtazapine and venlafaxine are two novel antidepressants which are pharmacologically different from other new anti-depressants. Mirtazapine blocks the presynaptic alpha 2-adrenoreceptors and has a benign safety profile. Venlafaxine particularly inhibits the reuptake of serotonin and in higher doses it inhibits the reuptake of norepinephrine as well. Its adverse events profile is similar to that of the selective serotonin reuptake inhibitors (SSRIs). Efficacy studies show that both compounds are effective in depressed outpatients. In depressed inpatients with psychotic features, suicidality or a longlasting episode mirtazapine is not effective and in such patients venlafaxine was not studied.
authors.affiliation: Stichting RBC, Den Haag.
authors.forename: T K
authors.initials: TK
authors.lastname: Birkenhäger
authors.forename: P
authors.initials: P
authors.lastname: Moleman
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D001549:Benzamides / Q000494:pharmacology; D003511:Cyclohexanols / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000078785:Mirtazapine; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011618:Psychotic Disorders / Q000188:drug therapy*; D020230:Serotonin Syndrome / Q000139:chemically induced; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000069470:Venlafaxine Hydrochloride
chemical_list: D000317:Adrenergic alpha-Antagonists; D001549:Benzamides; D003511:Cyclohexanols; D008803:Mianserin; D000078785:Mirtazapine; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride
vernacular_title: Twee nieuwe antidepressiva: mirtazapine en venlafaxine.