Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors.
Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroman are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta6-3-(dipropylamino)chroman]Cr(CO)3. Several of the compounds have high affinity for 5-HT1A receptors whereas the affinity for D2A receptors is lower, the 8-arylated derivatives being slightly more potent than the 8-aroylated analogues.
Caldirola
P
P
Organic Pharmaceutical Chemistry, Uppsala Biomedical Centre, Uppsala University, Sweden.
Chowdhury
R
R
Unelius
L
L
Mohell
N
N
Hacksell
U
U
Johansson
A M
AM
D000818:Animals; D001921:Brain / Q000378:metabolism; D002839:Chromans / Q000138:chemical synthesis*; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D017366:Serotonin Receptor Agonists / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002839:Chromans; D017448:Receptors, Dopamine D2; D017366:Serotonin Receptor Agonists