The "sins" of the fathers: self-healing squamous epithelioma in Scotland.
BACKGROUND
A review is presented of the recent progress made in mapping of the hereditary skin disease "Ferguson-Smith multiple self-healing squamous epithelioma."


METHODS
The use of founder effects in an autosomal dominant disease is reviewed as applied to gene mapping efforts.


RESULTS
A common haplotype among Scottish families segregating Ferguson-Smith disease allowed the narrowing of the candidate gene interval and the identification of several possible disease-associated genes.


CONCLUSIONS
The gene for Ferguson-Smith multiple self-healing squamous epithelioma lies in a narrow region on chromosome 9q, along with several other important hereditary skin disease loci.
Bale
S J
SJ
Genetic Studies Section/ LSB/ National Institute of Arthritis & Musculoskeletal & Skin Disease/ National Institutes of Health, Bethesda, Maryland 20892-2757, USA.
D001478:Basal Cell Nevus Syndrome / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D018703:Founder Effect; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D012606:Scotland; D012878:Skin Neoplasms / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics