Liquid phase parallel synthesis of guanidines.
Combinatorial synthesis of N,N'-di(Boc)-Protected guanidines containing piperazine and pyrrolidine scaffolds has been developed. We initiate a preliminary study on the reactivity of several guanylating reagents with soluble polymer-bound diamines in liquid phase. Guanidines are liberated from the polymer support under mild conditions in high yields and high purity by simple precipitation and washings. This combinatorial liquid-phase methodology proves to be a useful tool for constructing guanidine libraries containing diamine scaffolds.
Ho
K C
KC
Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien, Taiwan.
Sun
C M
CM
D002851:Chromatography, High Pressure Liquid; D006146:Guanidines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D019151:Peptide Library
D006146:Guanidines; D019151:Peptide Library