title: Late results of percutaneous mitral commissurotomy in a series of 1024 patients. Analysis of late clinical deterioration: frequency, anatomic findings, and predictive factors.
abstract: BACKGROUND
  The optimal use of percutaneous mitral commissurotomy (PMC) in a wide range of patients requires accurate evaluation of late results and identification of their predictors.
  
  
  RESULTS
  Late results of PMC were assessed in 1024 patients whose mean age was 49+/-14 years. Echocardiography showed that 141 patients (14%) had pliable valves and mild subvalvular disease, 569 (55%) had extensive subvalvular disease, and 314 (31%) had calcified valves. A single balloon was used in 26 patients, a double balloon in 390, and the Inoue Balloon in 608. Good immediate results were defined as valve area >/=1.5 cm2 without regurgitation >2/4 (Sellers' grade) and were obtained in 912 patients. Median duration of follow-up was 49 months. The 10-year actuarial rate of good functional results (survival with no cardiovascular death and no need for surgery or repeat dilatation and in New York Heart Association [NYHA] class I or II) was 56+/-4% in the entire population. Follow-up echocardiography was available in 90% of the patients who experienced poor functional results after good immediate results and showed restenosis in 97% of these. In multivariate analysis, the predictors of poor functional results were old age (P=0.0008), unfavorable valve anatomy (P=0.003), high NYHA class (P<0.0001), atrial fibrillation (P<0.0001), low valve area after PMC (P=0.001), high gradient after PMC (P<0.0001), and grade 2 mitral regurgitation after PMC (P=0.04).
  
  
  CONCLUSIONS
  PMC can be performed with good late results in a variety of patient subsets. Prediction of late events is multifactorial. Knowledge of these predictors can improve patient selection and follow-up.
authors.affiliation: Cardiology Department, Tenon Hospital, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Iung
authors.forename: E
authors.initials: E
authors.lastname: Garbarz
authors.forename: P
authors.initials: P
authors.lastname: Michaud
authors.forename: S
authors.initials: S
authors.lastname: Helou
authors.forename: B
authors.initials: B
authors.lastname: Farah
authors.forename: P
authors.initials: P
authors.lastname: Berdah
authors.forename: P L
authors.initials: PL
authors.lastname: Michel
authors.forename: B
authors.initials: B
authors.lastname: Cormier
authors.forename: A
authors.initials: A
authors.lastname: Vahanian
mesh_terms: D000328:Adult; D002404:Catheterization; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000503:physiopathology* / Q000628:therapy*; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012008:Recurrence; D012306:Risk; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome