[Pathological features of hepatocellular carcinoma carrying hepatitis C virus antigen].
OBJECTIVE
To analyze the pathological features of hepatocellular carcinomas (HCCs) carrying different hepatitis virus antigens histopathologically and systematically.


METHODS
PAP and ABC kits were used in the immunohistochemical study, and CAS-200 System was applied in the image cytometry.


RESULTS
As compared with HCCs carrying HBV marker(s), the HCCs carrying HCV marker showed more cases of clear cell type (7/9 vs 4/33), better differentiation of cancers, less necrosis of hepatocytes, milder lymphocyte infiltration in the hepatic sinuses or periportal areas (P < 0.01), higher incidence of bile ductule damages, and bore a close relation to the formation of lymphoid follicle in the surrounding tissues (P < 0.05). These patients were elder, with lower grade of symptoms and better prognosis after operation.


CONCLUSIONS
HCCs carrying only HCAg have different pathological features and clinical characteristics from which carrying HBV marker(s). The results of image cytometry are in accordance with the biological behaviour of HCC.
Liu
B
B
Department of Pathology, Shanghai Medical University, Shanghai.
Zhu
S
S
Zhang
X
X
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000821:virology; D005260:Female; D006511:Hepatitis B Antigens / Q000032:analysis; D018936:Hepatitis C Antigens / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged
D006511:Hepatitis B Antigens; D018936:Hepatitis C Antigens