Cooperation of Myb and Myc proteins in T cell lymphomagenesis.
The v-Myb oncogene causes late onset T cell lymphomas when expressed in the T cell lineage of transgenic mice. In order to define the cellular mutations cooperating with s-Myb to cause lymphomas, we have infected v-Myb transgenic mice with Moloney murine leukemia virus (M-MuLV). Tumor formation is significantly accelerated from a mean age of onset of 60 weeks in uninfected vMyb transgenics to 13 weeks in infected vMyb transgenics. We studied the loci into which the M-MuLV had inserted, and found that in 73% of animals, either the c-myc or the N-myc genes had been disrupted and deregulated. Therefore, v-myb and c-myb can cooperate to induce T cell lymphomas.
Davies
J
J
CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, London, UK.
Badiani
P
P
Weston
K
K
D017668:Age of Onset; D000818:Animals; D005434:Flow Cytometry; D015870:Gene Expression; D016259:Genes, myc / Q000235:genetics*; D009052:Leukemia Virus, Murine / Q000502:physiology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology / Q000821:virology; D051379:Mice; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D016254:Mutagenesis, Insertional; D020626:Oncogene Proteins v-myb; D009857:Oncogenes / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D013945:Thymoma / Q000235:genetics* / Q000473:pathology / Q000821:virology; D013953:Thymus Neoplasms / Q000235:genetics / Q000473:pathology / Q000821:virology
D020626:Oncogene Proteins v-myb; D012333:RNA, Messenger; D015682:Retroviridae Proteins, Oncogenic