[Comparison of hypervariable region gene of hepatitis C virus between an individual infected persistently and an individual recovered from infection].
OBJECTIVE
To explore the law of recovery from HCV infection.


METHODS
Amplifiying, sequenceing and analyzing the gene of hypervariable region from an individual infected persistently and an individual recovered from infection.


RESULTS
One base insertion (two clones, 10%) in the person recovered other than that infected persistently, but there is no difference between them in percentage of mumation, diversity of quasispecies and genetic distance among clones.


CONCLUSIONS
The range of genetic variation at one time point did not seem to have obvious relationship with the HCV persistent infection or recovery from HCV infection. This study gave basic information for searching the relation of genetic variation and clinical status, and designing HCV vaccine.
Pan
W
W
Institute of Microbiology and Epidemiology, Beijing.
Wang
H
H
Wang
T
T
D001483:Base Sequence; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D012367:RNA, Viral / Q000032:analysis
D012367:RNA, Viral