[ZAP genes: characterizing the protein structure of a new family of proliferation associated genes in the exocrine pancreas].
While interested in proliferation-dependent gene regulation in a pancreatic carcinoma cell line, we cloned a set of proteins (ZAP) characterized by a conserved region consisting of consecutive zinc finger, ankyrin repeat and PH domains. Functional aspects of these domains were obtained by comparison with proteins involved in several signal transduction pathways and cell cycle regulation. The members of the ZAP protein family are individually characterized by different types of supplementary protein domains, their chromosomal localization and their tissue specific gene transcription. All results indicate a wide spectrum of protein-protein interactions. Up to now specific binding partners have not been identified. In summary, the multiplicity of conserved regions and transcriptional data indicate a scaffold function for ZAP proteins in the complex network of proliferation associated intracellular signal transduction pathways.
Günther
R
R
I. Medizinische Klinik, Christian-Albrechts-Universität zu Kiel. rguenther@1med.uni-kiel.de
Zill
H
H
Schmidt
W E
WE
Fölsch
U R
UR
D000595:Amino Acid Sequence; D018797:Cell Cycle Proteins / Q000235:genetics*; D002455:Cell Division; D018816:Genes, cdc; D006801:Humans; D008969:Molecular Sequence Data; D010179:Pancreas / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D016335:Zinc Fingers / Q000235:genetics*
D018797:Cell Cycle Proteins
ZAP-Gene: Charakterisierung der Proteinstruktur einer neuen Familie proliferationsassoziierter Gene im exokrinen Pankreas.