title: [Chronic myeloid leukemia in health regions 1, 3, 4 and 5 during the period 1990-96].
abstract: The aim of the present investigation was to obtain information about treatment, clinical course and outcome for all patients with chronic myeloid leukaemia through a six-year period in a defined part of Norway. A total number of 141 patients fulfilled the diagnostic criteria. This is equivalent to 0.9 patients per 100,000 per year. The median age was 62 years. More than 70% of the patients were primarily treated with hydroxyurea, either alone or combined with interferon. 40 out of 57 patients younger than 55 years underwent allogeneic stem cell transplantation. Median survival for all patients was 36 months with an estimated five-year survival rate of 33%. Patients older than 55 years had a median survival of 30 months with 16% alive after five years. The five-year survival rate for patients younger than 55 years was 56%, for transplanted patients 72%. 60 of 84 patients older than 55 years have died after 4 1/2 years median observation time. Two thirds of those died of leukaemia; one third of other causes. 23 of 57 patients younger than 55 years have died. 11 of them had had transplantations and most of them died from transplantation-related causes, while leukaemia was the dominating cause of death in the others.
authors.affiliation: Medisinsk avdeling, Regionsykehuset i Trondheim.
authors.forename: J
authors.initials: J
authors.lastname: Lamvik
authors.forename: L
authors.initials: L
authors.lastname: Brinch
authors.forename: I M
authors.initials: IM
authors.lastname: Dahl
authors.forename: M
authors.initials: M
authors.lastname: Sjo
authors.forename: I
authors.initials: I
authors.lastname: Nesthus
authors.forename: J M
authors.initials: JM
authors.lastname: Tangen
authors.forename: S
authors.initials: S
authors.lastname: Berentsen
authors.forename: B
authors.initials: B
authors.lastname: Ly
authors.forename: F V
authors.initials: FV
authors.lastname: Shammas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002423:Cause of Death; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Kronisk myelogen leukemi i helseregion 1, 3, 4 og 5 i perioden 1990-96.