title: Intrahepatic cholangiocarcinoma with extensive sarcomatous change: report of a case.
abstract: A 77-year-old woman was admitted to our hospital with severe upper abdominal pain. Ultrasonography showed a well-defined hypoechoic mass with heterogeneity in the left lobe of the liver, and computed tomography demonstrated a low-density mass with enhanced peripheral areas. Magnetic resonance imaging revealed a mass with iso- to low signal intensity on T1-weighted images (WI) and heterogeneous high and low signal intensity on T2 WI. The tumor was found to be hypovascular by angiography. During 5 months of observation, the tumor increased in size, which strongly suggested malignancy. A laparotomy was performed under the provisional diagnosis of a neoplasm other than hepatocellular carcinoma, revealing that the hepatic mass had invaded the gastric wall. Therefore, a left hepatic lobectomy with dissection of the lymph nodes and hemigastrectomy was carried out. Histologically, the tumor was found to be composed of a large amount of sarcomatous elements and a small amount of adenocarcinomatous elements, both of which were partly intermingled. Immunohistochemically, the sarcomatous element demonstrated the features of malignant fibrous histiocytoma (MFH). Thus, a diagnosis of intrahepatic cholangiocarcinoma with MFH-like sarcomatous change was confirmed.
authors.affiliation: Department of Surgery, Nagasaki Prefectural Shimabara Onsen Hospital, Shimabara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsuo
authors.forename: T
authors.initials: T
authors.lastname: Shinozaki
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Takami
authors.forename: S
authors.initials: S
authors.lastname: Obata
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
authors.forename: T
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000473:pathology*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology