title: Histidine kinases and two-component signal transduction systems.
abstract: The phosphorylation of histidine is the first step in many signal transduction cascades in bacteria, yeast and higher plants. The transfer of a very reactive phosphoryl group from phosphorylated histidine kinase to an acceptor is an essential step in many cellular signaling responses.
authors.affiliation: Department of Chemistry, Levine Science Research Center, Box 90317, Duke University, Durham, NC 27708-0317, USA. pirrung@chem.duke.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Pirrung
mesh_terms: D001419:Bacteria / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial; D006639:Histidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D000071677:Histidine Kinase; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D047428:Protein Kinase Inhibitors; D006639:Histidine; D011494:Protein Kinases; D000071677:Histidine Kinase; C005436:phosphohistidine