Transfer RNA modification: influence on translational frameshifting and metabolism.
Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.
Björk
G R
GR
Department of Microbiology, Umeå University, Sweden. glenn.bjork@micro.umu.se
Durand
J M
JM
Hagervall
T G
TG
Leipuviene
R
R
Lundgren
H K
HK
Nilsson
K
K
Chen
P
P
Qian
Q
Q
Urbonavicius
J
J
D018965:Frameshifting, Ribosomal / Q000235:genetics / Q000502:physiology*; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism*
D012329:RNA, Bacterial; D012343:RNA, Transfer