title: Histological changes in the hearts of non-survivors of the UK collaborative trial of neonatal ECMO (extra corporeal membrane oxygen).
abstract: OBJECTIVE
  To study the cardiac pathology of infants enrolled in the UK collaborative trial of neonatal ECMO (extra corporeal membrane oxygen) who died following random allocation to a trial arm.
  
  
  METHODS
  During the trial, 81 infants died. The hearts of 26 babies were received and examined without knowledge of treatment regimen. The control group consisted of 14 infants who received conventional treatment. Twelve were allocated to ECMO; seven received this treatment.
  
  
  RESULTS
  In the control group, four showed minor histological changes. The other hearts were histologically normal. In the group treated with ECMO, four had multiple foci of micro-infarction throughout both ventricles and papillary muscles. There was variable thrombotic vascular occlusion. Three were normal. There was no correlation between cardiac pathology and clinical features. There was a significant difference in the length of survival between the two groups.
  
  
  CONCLUSIONS
  ECMO treatment seems to be associated with clinically significant cardiac pathology. The changes observed may reflect the longevity of survival in the ECMO group rather than an association with the treatment itself. Nevertheless, the findings have significant implications for those monitoring the development of infants surviving ECMO treatment and suggest that the monitoring of myocardial function will be crucial.
authors.affiliation: Department of Paediatric Pathology Royal Hospital for Sick Children Edinburgh EH9 1LF, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Evans
authors.forename: J W
authors.initials: JW
authors.lastname: Keeling
mesh_terms: D002102:Cadaver; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects* / Q000379:methods; D005865:Gestational Age; D006331:Heart Diseases / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D017202:Myocardial Ischemia / Q000209:etiology