title: Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo.
abstract: The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.
authors.affiliation: Department of Physiology, University of Maryland Medical School, Baltimore 21201, USA.
authors.forename: K
authors.initials: K
authors.lastname: Schorr
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: U
authors.initials: U
authors.lastname: Bar-Peled
authors.forename: A
authors.initials: A
authors.lastname: Lewis
authors.forename: A
authors.initials: A
authors.lastname: Heredia
authors.forename: B
authors.initials: B
authors.lastname: Lewis
authors.forename: C M
authors.initials: CM
authors.lastname: Knudson
authors.forename: S J
authors.initials: SJ
authors.lastname: Korsmeyer
authors.forename: R
authors.initials: R
authors.lastname: Jäger
authors.forename: H
authors.initials: H
authors.lastname: Weiher
authors.forename: P A
authors.initials: PA
authors.lastname: Furth
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival; D004847:Epithelial Cells / Q000502:physiology; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D051028:bcl-2-Associated X Protein
chemical_list: C494827:Bax protein, mouse; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein