title: Delivery rates after in-vitro fertilization following bilateral salpingectomy due to hydrosalpinges: a case control study.
abstract: This retrospective case-control study assessed the impact of bilateral salpingectomy due to uni- or bilateral hydrosalpinges on the outcome of in-vitro fertilization (IVF) in a large consecutive series of patients. The effect of bilateral salpingectomy due to hydrosalpinges on pregnancy outcome was compared in 139 patients (263 cycles) and 139 age-matched controls with tubal infertility without hydrosalpinges (296 cycles). The delivery rates per initiated cycle as well as the implantation rates were equal in the two groups (21.7 versus 21.6% and 19 versus 21%). The number of embryos, the cleavage stage, and the embryo morphology score were equal in the two groups. Among 92 patients treated with 182 IVF cycles who underwent salpingectomy between 1.5 and 5 years prior to their first IVF cycle, the delivery and the implantation rates were 22.5 and 20.5% respectively. Of the patients with salpingectomy after an average of 1.7 failed IVF cycles and who re-entered the IVF programme 3 and 6 months subsequent to surgery, 47 were treated with 83 IVF cycles. The live birth and the implantation rates after surgery in this group were 20.5 and 20% respectively. It is concluded that bilateral salpingectomy due to hydrosalpinges restores a normal delivery as well as implantation rate after IVF treatment compared to controls. A favourable outcome is also found in patients operated on after repeated IVF failures. Furthermore, a normal live birth rate as well as a high implantation rate is maintained for at least three IVF cycles subsequent to surgical treatment.
authors.affiliation: Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Denmark.
authors.forename: H E
authors.initials: HE
authors.lastname: Bredkjaer
authors.forename: S
authors.initials: S
authors.lastname: Ziebe
authors.forename: B
authors.initials: B
authors.lastname: Hamid
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: A
authors.initials: A
authors.lastname: Loft
authors.forename: A
authors.initials: A
authors.lastname: Lindhard
authors.forename: A N
authors.initials: AN
authors.lastname: Andersen
mesh_terms: D000328:Adult; D001723:Birth Rate; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D010064:Embryo Implantation / Q000502:physiology; D005184:Fallopian Tube Diseases / Q000601:surgery*; D005187:Fallopian Tubes / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011184:Postoperative Period; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies