Mitochondrial assembly in yeast.
The yeast Saccharomyces cerevisiae is likely to be the first organism for which a complete inventory of mitochondrial proteins and their functions can be drawn up. A survey of the 340 or so proteins currently known to be localised in yeast mitochondria reveals the considerable investment required to maintain the organelle's own genetic system, which itself contributes seven key components of the electron transport chain. Translation and respiratory complex assembly are particularly expensive processes, together requiring around 150 of the proteins so far known. Recent developments in both areas are reviewed and approaches to the identification of novel mitochondrial proteins are discussed.
Grivell
L A
LA
Section for Molecular Biology, Institute of Molecular Cell Biology, University of Amsterdam, The Netherlands.
Artal-Sanz
M
M
Hakkaart
G
G
de Jong
L
L
Nijtmans
L G
LG
van Oosterum
K
K
Siep
M
M
van der Spek
H
H
D000818:Animals; D004579:Electron Transport / Q000235:genetics; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008928:Mitochondria / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*
D005656:Fungal Proteins; D008565:Membrane Proteins