title: Expression of granulocyte colony-stimulating factor in recurrent glial tumors is inversely correlated with tumor progression.
abstract: We have previously reported that in vivo-expression of granulocyte colony-stimulating factor (G-CSF) is a characteristic feature of reactive and neoplastic astrocytes. The aim of the present study was to analyze the expression of G-CSF protein in primary and recurrent astroglial, oligodendroglial and mixed glial-differentiated tumors. G-CSF expression was present in all GFAP-positive tumors excepting glioblastomas. G-CSF expression was significantly reduced in recurrent tumors more dedifferentiated than their primary counterparts. G-CSF expression was absent in all GFAP-negative tumors such as oligodendrogliomas. Our results demonstrate that G-CSF is a highly sensitive differentiation marker of neoplastic astrocytes, which is lost during tumor progression.
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029-6574, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Stan
authors.forename: G F
authors.initials: GF
authors.lastname: Walter
authors.forename: K
authors.initials: K
authors.lastname: Welte
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: C A
authors.initials: CA
authors.lastname: Bona
authors.forename: T
authors.initials: T
authors.lastname: Pietsch
mesh_terms: D000293:Adolescent; D000328:Adult; D001253:Astrocytes / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation / Q000276:immunology; D003720:Densitometry; D018450:Disease Progression; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis; D005909:Glioblastoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009836:Oligodendroglia / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D009837:Oligodendroglioma / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D012008:Recurrence
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D016179:Granulocyte Colony-Stimulating Factor