Light mask 500 lux treatment for delayed sleep phase syndrome.
1. Bright light exposure has been demonstrated as an effective treatment for circadian rhythm sleep disorders. Recent studies suggest that more moderate intensities of light might affect endogenous rhythms. A light mask treatment, using light applied through eyelids during sleep, was tested for Delayed Sleep Phase Syndrome. 2. The active light group (n = 5) received 500 lux light for 3 hours prior to awakening for 12 days. The placebo light group (n = 5) received 0.1 lux light with the same timing. Circadian rhythm phase was assessed from core body temperature and urinary 6-sulfatoxymelatonin measurements. The SIGH-SAD-SR mood scale was administered to assess mood. 3. There were slight trends toward a phase advance of the body temperature rhythm and a phase delay of the melatonin rhythm, and both groups reported anti-depressant benefits. However, no statistically significant effects of 500 lux light mask treatment were demonstrated compared with the placebo-light treatment. 4. More extensive studies will be required to clarify the factors of dose-response and phase-response.
Ando
K
K
Department of Psychiatry, University of California, San Diego, USA.
Kripke
D F
DF
Cole
R J
RJ
Elliott
J A
JA
D000328:Adult; D000339:Affect / Q000502:physiology; D000704:Analysis of Variance; D015415:Biomarkers / Q000652:urine; D001831:Body Temperature / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000652:urine; D008875:Middle Aged; D010789:Phototherapy / Q000379:methods*; D012893:Sleep Wake Disorders / Q000628:therapy* / Q000652:urine; D013577:Syndrome
D015415:Biomarkers; C054513:6-sulfatoxymelatonin; D008550:Melatonin