Binding of chlorpheniramine enantiomers to human plasma proteins.
The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and alpha-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38% vs. 23%), to albumin (20% vs. 15%) and to alpha-glycoprotein acid (23% vs. 5%).
Hiep
B T
BT
Pitié Salpêtrière Hospital Pharmacy, Paris, France.
Gimenez
F
F
Khanh
V U
VU
Hung
N K
NK
Thuillier
A
A
Farinotti
R
R
Fernandez
C
C
D001798:Blood Proteins / Q000378:metabolism*; D002744:Chlorpheniramine / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D009961:Orosomucoid / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D013237:Stereoisomerism
D001798:Blood Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D002744:Chlorpheniramine