Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides.
OBJECTIVE
To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).


METHODS
The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.


RESULTS
PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.


CONCLUSIONS
The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.
Gong
S
S
Laboratory of Neurobiology, Suzhou Medical College, China.
Zhang
H Q
HQ
Yin
W P
WP
Yin
Q Z
QZ
Zhang
Y
Y
Gu
Z L
ZL
Qian
Z M
ZM
Tang
P L
PL
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007033:Hypothalamus, Middle / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000276:immunology / Q000502:physiology; D008297:Male; D017288:Pain Threshold; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D011124:Polyporaceae / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D007106:Immune Sera; D007376:Interleukin-2; D010455:Peptides; D011134:Polysaccharides