Specific IgG to gelatin in children with systemic immediate- and nonimmediate-type reactions to measles, mumps and rubella vaccines.
We examined anti-gelatin IgG in sera of children who suffered from systemic adverse reactions upon immunization with gelatin-containing live virus vaccines. In the group of 30 children who had immediate-type reactions and anti-gelatin IgE, 30 (100%) had anti-gelatin IgG and 29 (96%) had anti-gelatin IgG4. In another group of 75 children who had nonimmediate-type reactions and no anti-gelatin IgE, 22 (29%) had anti-gelatin IgG and six (8%) had IgG4. The IgG positivity well correlated with the lymphocyte proliferation assay positivity. In contrast, as a negative control, all 24 children who had no allergic reaction to live virus vaccines had no anti-gelatin IgG and IgG4. The results suggest that immune-response to gelatin may play a role in the pathogenesis of systemic nonimmediate-type reactions to the live virus vaccines.
Miyazawa
H
H
Department of Medical Technology, Kyorin University, Hachiohji, Tokyo, Japan. hiro_mzw@dl.dion.ne.jp
Saitoh
S
S
Kumagai
T
T
Yamanaka
T
T
Yasuda
S
S
Tsunetsugu-Yokota
Y
Y
Inouye
S
S
Sakaguchi
M
M
D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D002675:Child, Preschool; D005260:Female; D005780:Gelatin / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000209:etiology / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008458:Measles Vaccine / Q000009:adverse effects; D009108:Mumps Vaccine / Q000009:adverse effects; D012411:Rubella Vaccine / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects* / Q000276:immunology
D007074:Immunoglobulin G; D008458:Measles Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D014765:Viral Vaccines; D007073:Immunoglobulin E; D005780:Gelatin