[Reactivation of Trypanosoma cruzi infection in patients with acquired immunodeficiency syndrome].
A patient with AIDS and asymptomatic Chagas's disease and positive xenodiagnosis was taking ketoconazole in order to suppress parasitemia and prevent reactivation of Chagas's disease. Ketoconazole was unplanned suspended after 6 months, and the patient was admitted with fever, headache, vomiting, tachycardia, postural hypotension, hepatosplenomegaly, and positive xenodiagnosis one month later. Treatment with benzonidazole was begun leading to suppression of parasitemia. The patient had probability a neurotoxoplasmosis associated and progressed to coma and death with sepsis. No parasite was found in autopsy.
Galhardo
M C
MC
Laboratório de Pesquisa Clínica e de Anatomia Patológica do Centro de Pesquisa do Hospital Evandro Chagas, Rio de Janeiro, Brasil.
Martins
I A
IA
Hasslocher-Moreno
A
A
Xavier
S S
SS
Coelho
J M
JM
Junqueira
A C
AC
dos Santos
R R
RR
Vasconcelos
A C
AC
Ribeiro
R dos S
Rdos S
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D014355:Chagas Disease / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use; D012008:Recurrence; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014349:Trypanosoma cruzi
D000935:Antifungal Agents; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D007654:Ketoconazole; C009999:benzonidazole
Reativação da infecção por Trypanosoma cruzi em paciente com síndrome de imunodeficiência adquirida.