title: Evaluation of fetal lung maturity in diamniotic twins.
abstract: OBJECTIVE
  This study was undertaken to evaluate the correspondence in fetal lung development between diamniotic twins.
  
  
  METHODS
  Lecithin/sphingomyelin ratios were determined for amniotic fluid specimens collected from each sac in 58 diamniotic twin pregnancies.
  
  
  RESULTS
  Overall, the lecithin/sphingomyelin ratios of twin A and twin B and those of the larger and smaller twins of each pair were closely correlated (r >/= 0.83, P <.001). When stratified by gestational age, however, the percentage disparity in lecithin/sphingomyelin ratios between members of twin pairs was significantly greater at </=32 weeks' gestation (25%) than at >32 weeks' gestation (15%, P =.027). An analysis of the lecithin/sphingomyelin ratios of twins with a large lecithin/sphingomyelin ratio disparity (>/=20%) suggested that this disparity was a result of 1 twin having a lecithin/sphingomyelin ratio that was advanced for gestational age with respect to that of the co-twin. Disparities in lecithin/sphingomyelin ratio were not significantly affected by fetal sex or by discordance in size between the twins.
  
  
  CONCLUSIONS
  At relatively early stages of diamniotic twin gestation (</=32 weeks' gestation), lecithin/sphingomyelin ratios should be obtained for both amniotic sacs to ensure accurate assessment of fetal lung maturity in both twins.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.
authors.forename: N S
authors.initials: NS
authors.lastname: Whitworth
authors.forename: E F
authors.initials: EF
authors.lastname: Magann
authors.forename: J C
authors.initials: JC
authors.lastname: Morrison
mesh_terms: D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry*; D005260:Female; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000196:embryology*; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D013109:Sphingomyelins / Q000032:analysis*; D014427:Twins
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins