title: Blood glucose responses in humans mirror lactate responses for individual anaerobic threshold and for lactate minimum in track tests.
abstract: The equilibrium point between blood lactate production and removal (La-(min)) and the individual anaerobic threshold (IAT) protocols have been used to evaluate exercise. During progressive exercise, blood lactate [La-]b, catecholamine and cortisol concentrations, show exponential increases at upper anaerobic threshold intensities. Since these hormones enhance blood glucose concentrations [Glc]b, this study investigated the [Glc] and [La-]b responses during incremental tests and the possibility of considering the individual glucose threshold (IGT) and glucose minimum (Glc(min)) in addition to IAT and La-(min) in evaluating exercise. A group of 15 male endurance runners ran in four tests on the track 3000 m run (v3km); IAT and IGT - 8 x 800 m runs at velocities between 84% and 102% of v3km; La-(min) and Glc(min) - after lactic acidosis induced by a 500-m sprint, the subjects ran 6 x 800 m at intensities between 87% and 97% of v3km; endurance test (ET) - 30 min at the velocity of IAT. Capillary blood (25 microl) was collected for [La-]b and [Glc]b measurements. The IAT and IGT were determined by [La-]b and [Glc]b kinetics during the second test. The La-(min) and Glc(min) were determined considering the lowest [La-] and [Glc]b during the third test. No differences were observed (P < 0.05) and high correlations were obtained between the velocities at IAT [283 (SD 19) and IGT 281 (SD 21) m. x min(-1); r = 0.096; P < 0.001] and between La-(min) [285 (SD 21)] and Glc(min) [287 (SD 20) m. x min(-1) r = 0.77; P < 0.05]. During ET, the [La-]b reached 5.0 (SD 1.1) and 5.3 (SD 1.0) mmol x l(-1) at 20 and 30 min, respectively (P > 0.05). We concluded that for these subjects it was possible to evaluate the aerobic capacity by IGT and Glc(min) as well as by IAT and La-(min).
authors.affiliation: Department of Physiological Sciences at São Carlos Federal University-UFSCar, São Paulo, Brazil.
authors.forename: H G
authors.initials: HG
authors.lastname: Simões
authors.forename: C S
authors.initials: CS
authors.lastname: Grubert Campbell
authors.forename: E
authors.initials: E
authors.lastname: Kokubun
authors.forename: B S
authors.initials: BS
authors.lastname: Denadai
authors.forename: V
authors.initials: V
authors.lastname: Baldissera
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010807:Physical Endurance / Q000502:physiology; D012420:Running / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D019344:Lactic Acid