title: Pregnancy following cardiac valve replacement surgery.
abstract: OBJECTIVE
  To study the outcome of pregnancy in women with artificial heart valves and to compare the maternal and perinatal outcome in mechanical and bioprosthetic valves.
  
  
  METHODS
  Retrospective analysis of 34 pregnancies in 29 women who conceived after cardiac valve replacement was carried out.
  
  
  RESULTS
  The majority of women (76.4%) delivered within 5 years of valve replacement. Anticoagulants were administered in 79.4% of pregnancies. Maternal mortality was 2.9% and maternal morbidity in the form of heart failure, atrial fibrillation, valve thrombosis, thromboembolism, bleeding complications and non-functioning prostheses were 2.9%, 5.8%, 2.9%, 2.9%, 11.7% and 2.9%, respectively. The incidence of prematurity was 5.8% and small for gestational age babies was 11.7%. There was no case of abortion. Two babies (5.8%) were still born, one of which had malformations. Maternal complications were significantly higher in women with bioprostheses, though the complications were more grave in the mechanical prostheses group. The perinatal outcome was almost similar in both the groups.
  
  
  CONCLUSIONS
  The perinatal outcome was not different in women with bioprosthetic valves from the ones with mechanical prostheses, but the maternal morbidity was more in women with bioprosthetic valves. Coumarin derivatives were safe and effective and did not lead to embryopathy.
authors.affiliation: Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: V
authors.initials: V
authors.lastname: Suri
authors.forename: H
authors.initials: H
authors.lastname: Sawhney
authors.forename: K
authors.initials: K
authors.lastname: Vasishta
authors.forename: T
authors.initials: T
authors.lastname: Renuka
authors.forename: A
authors.initials: A
authors.lastname: Grover
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants