title: Migratory potential of transplantable neural tumor cell lines.
abstract: Experimentally induced primitive neuroectodermal tumor (PNET) cell lines were transplanted into neonatal and adult rat brain and examined neuropathologically for their tumorigenic potential. Both cell lines showed a striking migratory behavior in both neonatal and adult brain. Migration of tumor cells was found in host brain parenchyma, along white matter tracts and associated with CSF pathways. These neural tumor cell lines provide a valuable tool for the development of strategies against strongly migrating neural tumors.
authors.affiliation: Department of Psychiatry, University of Bonn Medical Center, Germany. bayer@uni-bonn.de
authors.forename: T A
authors.initials: TA
authors.lastname: Bayer
authors.forename: M
authors.initials: M
authors.lastname: Thier
authors.forename: E
authors.initials: E
authors.lastname: Roeb
authors.forename: B
authors.initials: B
authors.lastname: Breuer
authors.forename: S
authors.initials: S
authors.lastname: Weggen
authors.forename: O D
authors.initials: OD
authors.lastname: Wiestler
authors.forename: J
authors.initials: J
authors.lastname: Weis
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology*; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D051381:Rats; D019737:Transplants; D014407:Tumor Cells, Cultured
chemical_list: D020778:Matrix Metalloproteinase 2