[Distinct genotypes of TTV infection in non A-non C hepatitis].
TTV DNA was tested by polymerase chain reaction with two set primers(NG061/NG063, T801/T935) in patients with nonA-nonC acute and chronic hepatitis. TTV DNA was detected in 75.9-100% by T801/T935, 47.1-48.3% by NG061/NG063 of 46 patients. The nucleotide sequences including 185 bp in the N22 region of 22 TTV DNA isolates from patients with acute and chronic nonA-nonC hepatitis, were classified into various TTV genotypes such as 1a, 1b and non-1. Our results demonstrate that genotype 1b may induce hepatic injury.
Hoshino
H
H
Hino
K
K
Iwasa
Y
Y
Takahashi
K
K
Sandai
T
T
Yoshisawa
K
K
Iino
S
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D015415:Biomarkers / Q000032:analysis; D004266:DNA Virus Infections / Q000453:epidemiology / Q000821:virology*; D004267:DNA Viruses / Q000235:genetics*; D004279:DNA, Viral / Q000032:analysis*; D005838:Genotype; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D015415:Biomarkers; D004279:DNA, Viral