[Pancreatic ischemia: a continuous injury factor in acute necrotic pancreatitis].
ANP model in rats was used to determine the concentration of TXB2, PGF1 alpha in plasma and the ACE activity in serum in five groups. The concentration of TXB2, PGF1 alpha in all experimental groups was significantly different from that of control group (P < 0.05). The comparison of ACE activity was just the same as the above except that of 6 h. The factors leading to pancreatic ischemia functioned continously. We conclude that pancreatic ischemia is a continuous injury factor in ANP, and there is no reperfusion-injury in the course of the disease.
Mao
E
E
Department of General Surgery, Ruijin Hospital, Shanghai.
Zhang
S
S
Han
T
T
D000818:Animals; D005260:Female; D007511:Ischemia / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000098:blood supply*; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000139:chemically induced; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011460:Prostaglandins F / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013656:Taurocholic Acid; D013929:Thromboxane B2 / Q000097:blood*
D011460:Prostaglandins F; D013929:Thromboxane B2; D013656:Taurocholic Acid; D007703:Peptidyl-Dipeptidase A; C100006:prostaglandin F1