title: Susceptibility to oxidation of copper-induced plasma lipoproteins from Japanese eel: protective effect of vitellogenin on the oxidation of very low density lipoprotein.
abstract: The susceptibility to oxidation of copper-induced plasma lipoproteins from Japanese eel Anguilla japonica was examined with the guidance of thiobarbituric acid-reactive substances (TBARS). The TBARS values of copper-induced plasma lipoproteins increased with increasing the lipid-to-apolipoprotein ratios and very low density lipoprotein (VLDL) exhibited the highest TBARS value. On the other hand, vitellogenin, estrogen-induced precursor of egg yolk proteins, was resistant to copper-induced oxidation and seemed to chelate low concentrations of copper ion. Vitellogenin also protected the copper-induced oxidation of VLDL because of its antioxidant function. Vitellogenin seemed to serve as transition metals-binding lipoprotein by which free-radical reactions in the oocytes were extensively depressed.
authors.affiliation: Department of Fisheries Science, Kagoshima University, Japan. ando@chem.fish.kagoshima-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Yanagida
mesh_terms: D000811:Anguilla / Q000097:blood*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000187:drug effects; D010084:Oxidation-Reduction; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014819:Vitellogenins / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008079:Lipoproteins, VLDL; D017392:Thiobarbituric Acid Reactive Substances; D014819:Vitellogenins; D004958:Estradiol; D003300:Copper