CD5 expression in human B-cell populations.
The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells. Here, Pierre Youinou, Christophe Jamin and Peter Lydyard review current knowledge of B-1 and B-2 cells, and propose that CD5 has different functions when expressed by different B-cell subpopulations.
Youinou
P
P
Laboratory of Immunology, Institut de Synergie des Sciences et de la Santé, Brest University Medical School Hospital, BP 824, F-29609 Brest Cedex, France. youinou@univ-brest.fr
Jamin
C
C
Lydyard
P M
PM
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D017209:Apoptosis; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D018956:CD5 Antigens / Q000378:metabolism*; D002455:Cell Division; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D018956:CD5 Antigens; C064228:CD72 protein, human; D008024:Ligands