title: Acute lymphoblastic leukemia with multiple cytogenetic abnormalities secondary to treatment of Ewing's sarcoma.
abstract: We report the case of a 22-year-old man with Ewing's sarcoma who attained a complete remission (CR) after combination radiotherapy and chemotherapy. Secondary acute lymphoblastic leukemia with multiple cytogenetic abnormalities involving chromosome 5 and 7 developed 16 years later. The patient underwent induction chemotherapy and entered a CR. Peripheral blood stem cell transplantation from a matched sibling was performed successfully and he is in complete remission of both ALL and Ewing's sarcoma.
authors.affiliation: Department of Medicine, Princess Margaret Hospital and The University of Toronto, Ont., Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Al-Homaidhi
authors.forename: B
authors.initials: B
authors.lastname: Patterson
authors.forename: S
authors.initials: S
authors.lastname: Rubin
authors.forename: J H
authors.initials: JH
authors.lastname: Lipton
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology / Q000235:genetics*; D011878:Radiotherapy / Q000009:adverse effects; D012512:Sarcoma, Ewing / Q000235:genetics*
chemical_list: D018906:Antineoplastic Agents, Alkylating