title: The adenocarcinoma of the larynx: in aim of a clinic case. Histologic, immuno-histochemistry and electron microscope studies.
abstract: Adenocarcinoma "not otherwise specified" of the larynx appears to be extremely rare. We report a case of adenocarcinoma "NOS" arising in the larynx of a 72 year-old white man. The neoplasia was ALCIAN and PAS negative. Immuno-histochemical studies revealed negative immunoreactivity from NSE, chromogranins and S100; cytokeratin was positive. Electron microscopy revealed electrodense granules of varying sizes, but with no obvious central core surrounded by a limiting membrane. The patient underwent a total laryngectomy and functional neck dissection, with mandibular extension. And he is free of tumor after 4 years postoperatively.
authors.affiliation: Istituto di Clinica Otorinolaringoiatrica, Policlinico P. Giaccone, Universita di Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Incandela
authors.forename: F
authors.initials: F
authors.lastname: Aragona
authors.forename: G
authors.initials: G
authors.lastname: Di Marco
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008854:Microscopy, Electron