[Study on microsatellite instability in gastric cancer].
OBJECTIVE
To evaluate the microsatellite instability (MIN) in gastric cancers (GC).


METHODS
MIN was examined in 106 cases of GC, using the radioactive polymerase chain reaction-based method.


RESULTS
The frequency of MIN was significantly higher in expanding type of GC as compared with the infiltrative type (P < 0.005, chi 2 test). No significant association with histologic type, pTNM stage, age and sex was found (P > 0.05, chi 2 test).


CONCLUSIONS
These findings reveal that MIN might be an important contributor to the development and progress of a significant number of GC, especially the expanding type which, as acknowledged traditionally, has a favorable prognosis.
Cai
J
J
Department of Oncology, Union Hospital Affiliated to Fujian Medical University, Fuzhou.
You
F
F
Zhang
X
X
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics*