title: Giant cell angiofibroma of the orbit and eyelid.
abstract: OBJECTIVE
  To report the clinicopathologic features of a newly recognized tumor, giant cell angiofibroma.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Clinical and histopathologic features of giant cell angiofibroma.
  
  
  METHODS
  Light and electron microscopy and immunohistochemistry of five cases of giant cell angiofibroma.
  
  
  RESULTS
  A total of five patients (4 women and 1 man) are described: two presented with a painless mass in the eyelid, two with a mass in the orbit, and one presented with a conjunctival lesion. All lesions were well demarcated with no capsule and were composed of blood vessels, a patternless spindle-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin.
  
  
  CONCLUSIONS
  Giant cell angiofibroma resembles solitary fibrous tumor and giant cell fibroblastoma and should be considered in the differential diagnosis of spindle-cell tumors in the eyelid, orbit, and conjunctiva.
authors.affiliation: Wilmer Ophthalmological Institute, and Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: G
authors.initials: G
authors.lastname: Borodic
authors.forename: J W
authors.initials: JW
authors.lastname: Karesh
authors.forename: M J
authors.initials: MJ
authors.lastname: Tolentino
authors.forename: H D
authors.initials: HD
authors.lastname: Remulla
authors.forename: R A
authors.initials: RA
authors.lastname: Van Wesep
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: F A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: W R
authors.initials: WR
authors.lastname: Green
mesh_terms: D000368:Aged; D018322:Angiofibroma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D018952:Antigens, CD34 / Q000032:analysis; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005870:Giant Cell Tumors / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014746:Vimentin