title: Thermogenic response to adrenaline during restricted blood flow in the forearm.
abstract: To elucidate the underlying mechanism behind the thermogenic effect of adrenaline in human skeletal muscle, nine healthy subjects were studied during intravenous infusion of adrenaline. Restriction of blood flow to one forearm was obtained by external compression of the brachial artery, to separate a direct metabolic effect of adrenaline from an effect dependent on increased blood flow. The other arm served as the control arm. In the control arm, the forearm blood flow increased 4.7-fold (from 2.0 +/- 0.3 to 9.3 +/- 1.5 mL 100 g(-1) min(-1), P < 0.001) during the adrenaline infusion. Adrenaline significantly increased forearm oxygen consumption (from 4.7 +/- 2.1 to 7.0 +/- 3.6 micromol 100 g(-1) min(-1), P < 0.025). In the arm with restricted blood flow, the forearm blood flow increased 2.9-fold (from 1.6 +/- 0.3 to 4.6 +/- 0.8 mL 100 g(-1) min(-1), P < 0.002) but the forearm oxygen consumption did not increase (baseline period: 5.6 +/- 2.3 micromol 100 g(-1) min(-1), adrenaline period: 6.1 +/- 2.1 micromol 100 g(-1) min(-1), P = 0.54). The experimental design and the difficulties in interpretation of the result are discussed. The results give evidence for the hypothesis that the vascular system plays a key role in the thermogenic effect of adrenaline in skeletal muscle in vivo.
authors.affiliation: Department of Clinical Physiology/Nuclear Medicine, Bispebjerg Hospital, Copenhagen, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Simonsen
authors.forename: B
authors.initials: B
authors.lastname: Stefl
authors.forename: N J
authors.initials: NJ
authors.lastname: Christensen
authors.forename: J
authors.initials: J
authors.lastname: Bülow
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply; D000328:Adult; D001786:Blood Glucose; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D004837:Epinephrine / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D005542:Forearm / Q000098:blood supply; D005990:Glycerol / Q000097:blood; D006801:Humans; D007275:Injections, Intravenous; D019344:Lactic Acid / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage* / Q000097:blood
chemical_list: D001786:Blood Glucose; D014662:Vasoconstrictor Agents; D019344:Lactic Acid; D005990:Glycerol; D004837:Epinephrine