title: Fatal outbreaks of proliferative enteritis caused by Lawsonia intracellularis in young colony-raised rhesus macaques.
abstract: Ten juvenile rhesus monkeys (Macaca mulatta) died acutely in two separate disease outbreaks. The animals had segmental thickening of the distal ileum with associated proliferative, rugous appearing mucosae. Microscopically, necrosis, exudative inflammation, mucosal ulceration, and crypt hyperplasia were present. Intracellular organisms were seen histochemically and ultrastructurally, and were confirmed to be Lawsonia intracellularis using a specific immunohistochemical method. Proliferative enteropathic conditions caused by L. intracellularis are reported in an ever-increasing range of hosts, suggesting that the infection may exist unrecognized in an even greater array of species, possibly including man.
authors.affiliation: Division of Laboratory Animal Resources, University of Pittsburgh, PA 15261, USA. eklein+@pitt.edu
authors.forename: E C
authors.initials: EC
authors.lastname: Klein
authors.forename: C J
authors.initials: CJ
authors.lastname: Gebhart
authors.forename: G E
authors.initials: GE
authors.lastname: Duhamel
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification / Q000472:pathogenicity / Q000648:ultrastructure; D001424:Bacterial Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary*; D004751:Enteritis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008253:Macaca mulatta / Q000382:microbiology*; D008297:Male; D008854:Microscopy, Electron; D008992:Monkey Diseases / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology; D013045:Species Specificity; D013552:Swine / Q000382:microbiology