title: Fas (APO-1/CD95) in inflammatory CNS diseases: intrathecal release in bacterial meningitis.
abstract: Release of Fas (APO-1, CD95), a type L-membrane protein which plays a crucial role in cytokine-mediated apoptosis was investigated in bacterial meningitis, viral meningoencephalitis and multiple sclerosis in vivo. After correction for bloodbrain-CSF-disruption, significantly increased intrathecal release of Fas was demonstrated exclusively in bacterial meningitis arguing for an apoptotic cell death of granulocytes in the subarachnoidal space aimed to self-limit inflammatory host response.
authors.affiliation: Department of Neurology, Klinikum Mannheim, University of Heidelberg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Fassbender
authors.forename: C
authors.initials: C
authors.lastname: Eschenfelder
authors.forename: M
authors.initials: M
authors.lastname: Hennerici
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001324:Autoantigens / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier / Q000276:immunology; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D006098:Granulocytes / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*; D008875:Middle Aged; D012995:Solubility; D019014:fas Receptor / Q000097:blood / Q000134:cerebrospinal fluid* / Q000276:immunology*
chemical_list: D001324:Autoantigens; D019014:fas Receptor