Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils.
The influence of transient forebrain ischemia on behavioral performance, and the effect of intracerebroventricular (i.c.v.) injection of acidic fibroblast growth factor (aFGF) on such ischemia-induced deficits were examined in Mongolian gerbils by assessing learning and memory in two tasks: passive avoidance and Morris water maze. A 5-min period of forebrain ischemia led to learning and memory deficits in both tasks, and also to neuronal death in the hippocampal CA1 region. Continuous i.c.v. infusion of aFGF bilaterally into the lateral ventricules by osmotic minipumps over 2 days before, and 5 days after the ischemia (a total of 3.6 microg/gerbil) largely prevented both the ischemia-induced behavioral deficits and the neuronal death in the hippocampus. These observations suggest that the hippocampus is a critical site for the performance of the two tasks, and that aFGF has a protective effect against such ischemia-induced learning and memory deficits in gerbils.
Li
A J
AJ
Department of Physiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. liai-jun@nibh.go.jp
Oomura
Y
Y
Sasaki
K
K
Suzuki
K
K
Hori
T
T
D000647:Amnesia / Q000503:physiopathology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology*; D001931:Brain Mapping; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D011939:Mental Recall / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects / Q000503:physiopathology
D018696:Neuroprotective Agents; D016220:Fibroblast Growth Factor 1