[New pharmacologic strategies for the treatment of Parkinson disease].
The dopamine precursor, levodopa, and the synthetic dopamine agonists are drugs widely used to alleviate the motor symptoms of idiopathic Parkinson's disease. Recently, several molecules which act on different pharmacological receptors implied in Parkinson's disease pathophysiology, have been developed to be applied as a treatment for its motor and cognitive symptoms. This paper discusses these novel therapeutical strategies, their mechanism of action, and their potential applications. To facilitate its lecture, the article has been structured in several sections. In the first section, drugs acting on dopamine metabolism are described, in the next part recent studies on new dopamine agonists and drugs acting on non-dopamine neuronal receptors are analysed, and finally the role of trophic factors for the treatment of Parkinson's disease is discussed.
Tolosa
E
E
Servicio de Neurología, Hospital Clínic i Universitari, Universitat de Barcelona.
Molinuevo
J L
JL
Valldeoriola
F
F
Pastor
P
P
D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*
D000978:Antiparkinson Agents
Nuevas estrategias farmacológicas para el tratamiento de la enfermedad de Parkinson.