Low IGF-I levels in hip fracture patients. A comparison of 20 coxarthrotic and 23 hip fracture patients.
We measured total body bone density and body composition with dual energy x-ray absorptiometry in 43 elderly patients, 23 with hip fracture and 20 with coxarthrosis, after surgery and after 6 months. Insulin-like growth factor-1 (IGF-I), a polypeptide known to affect bone metabolism, and two of its binding proteins (IGFBP-1, IGFBP-3) were measured preoperatively and after 6 months. Normal serum IGF-I levels are dependent on adequate nutrition and normal secretion of growth hormone (GH). We found consistently lower levels of IGF-I and IGFBP-3 and a tendency to higher levels of IGFBP-1 in the patients with hip fractures, who also had a lower total body mass, lower fat mass and bone mineral density than the coxarthrosis group, indicating a more catabolic state in the patients with hip fracture, even 6 months after the trauma.
Hedström
M
M
Karolinska Institute, Department of Orthopedics, Danderyd Hospital, Sweden.
Sääf
M
M
Dalén
N
N
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006620:Hip Fractures / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011877:Radionuclide Imaging; D012044:Regression Analysis
D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone