title: The non-surgical treatments of hepatocellular carcinomas in a patient with severe hemophilia A.
abstract: We recently treated a patient with multiple hepatocellular carcinomas (HCC) who had severe hemophilia A and thrombocytopenia secondary to cirrhosis. He was not a candidate for surgery because of his liver failure. Transcatheter arterial chemoembolization and percutaneous ethanol injection therapy were successfully performed without complications by maintaining factor VIII levels above 40%. We believe that the non-surgical treatment of HCC can be performed safely in patients with coagulation disorders, by the appropriate administration of coagulation factors, despite thrombocytopenia and/or elongation of the prothrombin time from cirrhosis.
authors.affiliation: Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Toyoda
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
authors.forename: I
authors.initials: I
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Katano
authors.forename: M
authors.initials: M
authors.lastname: Ebata
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Nagano
authors.forename: S
authors.initials: S
authors.lastname: Yokozaki
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: J
authors.initials: J
authors.lastname: Takamatsu
mesh_terms: D000328:Adult; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000150:complications / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D015251:Epirubicin / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D005169:Factor VIII / Q000008:administration & dosage / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000098:blood supply / Q000150:complications / Q000628:therapy*; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D000431:Ethanol; D015251:Epirubicin; D005169:Factor VIII