title: Bioassays for itraconazole blood levels: an interlaboratory collaborative study.
abstract: Duplicate bioassays for itraconazole and hydroxy-itraconazole were run with 30 serum samples in five laboratories, each using a different method. Both itraconazole and hydroxy-itraconazole were used as standards. Despite quantitative variations, the results of the bioassays correlated sufficiently to indicate the relative level of antifungal activity in the test samples.
authors.affiliation: Janssen Research Foundation, Beerse, Belgium.
authors.forename: F C
authors.initials: FC
authors.lastname: Odds
authors.forename: B
authors.initials: B
authors.lastname: Dupont
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
authors.forename: D W
authors.initials: DW
authors.lastname: Warnock
authors.forename: R
authors.initials: R
authors.lastname: Woestenborghs
mesh_terms: D000935:Antifungal Agents / Q000097:blood*; D001681:Biological Assay / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D017964:Itraconazole / Q000031:analogs & derivatives / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole