Intraoperative electromyography for predicting facial function in vestibular schwannoma surgery.
OBJECTIVE
To assess the validity of intraoperative minimal stimulation threshold (MST) for predicting long-term facial function after vestibular schwannoma surgery.


METHODS
Prospective blinded study.


METHODS
MST after tumor dissection and postoperative clinical facial function, assessed using the House Brackmann grading system (HB), were used to predict long-term clinical facial function, recorded at least 6 months after surgery.


RESULTS
Two hundred and nine consecutive patients fulfilled selection criteria and 184 had successful intraoperative electrophysiologic monitoring and were eligible for further study. MST of 0.05 mA had moderate accuracy for predicting good long-term facial function, with 94% sensitivity, 91% positive predictive value (PPV), 60% specificity, and 70% negative predictive value (NPV). A more relevant group of 77 patients with poor postoperative facial function (HB III-VI) were assessed for predicting good long-term function. Applying this criteria, test accuracy fell, with 83% sensitivity, 64% PPV, 60% specificity, and 75% NPV. Postoperative clinical facial function had a greater accuracy for predicting good long-term function, with 83% sensitivity, 79% PPV, 75% specificity, and 79% NPV. A model of predicted probabilities of good outcome (HB I and II) was derived from a logistic regression with two additive predictors (postoperative HB and MST). This demonstrated that for patients with postoperative HB grade V, MST aided prediction.


CONCLUSIONS
Intraoperative stimulation thresholds, when assessed against a relevant group of patients with poor postoperative facial function, had poor predictive accuracy. The severity of immediate postoperative clinical facial function was the most accurate predictor of long-term outcome. MST aided long-term prediction in a small but relevant group of patients with postoperative HB grade V facial function.
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University Department of Otolaryngology, Manchester Royal Infirmary, United Kingdom.
Ramsden
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RT
D002528:Cerebellar Neoplasms / Q000503:physiopathology* / Q000601:surgery*; D002530:Cerebellopontine Angle; D004576:Electromyography; D005154:Facial Nerve / Q000503:physiopathology*; D020220:Facial Nerve Injuries; D006801:Humans; D016015:Logistic Models; D016343:Monitoring, Intraoperative; D009442:Neurilemmoma / Q000503:physiopathology* / Q000601:surgery*; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016037:Single-Blind Method; D015837:Vestibular Diseases / Q000503:physiopathology* / Q000601:surgery*