Sensitivity of amoxicillin-resistant Helicobacter pylori to other penicillins.
The sensitivities to penicillins and to a penicillin and beta-lactamase inhibitor combination agent were determined for Helicobacter pylori strains that were sensitive, moderately resistant, or highly resistant to amoxicillin. All strains were resistant to nafcillin and oxacillin. Moderately resistant strains showed an intermediate zone of inhibition to ticarcillin, mezlocillin, piperacillin, and amoxicillin-clavulanic acid. High-level resistance was associated with the smallest zone size for all penicillins tested.
Dore
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MP
Department of Medicine, VA Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA. mariap@bcm.tmc.edu
Graham
D Y
DY
Sepulveda
A R
AR
Realdi
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G
Osato
M S
MS
D000658:Amoxicillin / Q000494:pharmacology*; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000187:drug effects; D004352:Drug Resistance, Microbial; D016480:Helicobacter pylori / Q000187:drug effects*; D006602:Hexosyltransferases; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000187:drug effects; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000494:pharmacology*; D010458:Peptidyl Transferases
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase