title: Contribution of color and power Doppler sonography to the differential diagnosis of acute and chronic rejection, and tacrolimus nephrotoxicity in renal allografts.
abstract: The aim of the present study was to differentiate acute rejection, chronic rejection, and tacrolimus nephrotoxicity with color and power Doppler imaging of renal transplants. One hundred examinations were obtained from 45 patients. Pulsatility and resistive indices were calculated from color Doppler images. The grade of renal vascularization was quantified using computer-assisted pixel analysis in a rectangular region-of-interest. The percentage of vessel-covered renal parenchyma (POV) was calculated using a histogram that discriminated renal vessels from renal parenchyma via power Doppler images. Furthermore, the distance from the most peripherally located vessels to the renal capsule (PVD) was measured. A reduced POV < or = 55% proved to be the best discriminator when chronic rejection was suspected (sensitivity 79%, specificity 87%). Tacrolimus nephrotoxicity showed not only a moderate elevation of the Doppler signal but also an increased PVD > or = 3.9 mm and a normal POV. We conclude that the evaluation of renal vessels by power Doppler images improves diagnostic accuracy for patients with renal allografts.
authors.affiliation: Department of Radiology, Klinik für Strahlenheilkunde, Charité Campus Virchow-Klinikum, Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Venz
authors.forename: A
authors.initials: A
authors.lastname: Kahl
authors.forename: J
authors.initials: J
authors.lastname: Hierholzer
authors.forename: M
authors.initials: M
authors.lastname: Gutberlet
authors.forename: B
authors.initials: B
authors.lastname: Windrich
authors.forename: W O
authors.initials: WO
authors.lastname: Bechstein
authors.forename: N
authors.initials: N
authors.lastname: Hosten
authors.forename: U
authors.initials: U
authors.lastname: Frei
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007668:Kidney / Q000000981:diagnostic imaging; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000009:adverse effects*; D014184:Transplantation, Homologous; D018608:Ultrasonography, Doppler; D018615:Ultrasonography, Doppler, Color
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus