title: Early use of coronary angiography and intervention.
abstract: In this article we have outlined the current rationale and role of invasive management in ACS. For the majority of patients with ACS, who are either at high risk or unstable, invasive management is a critical element in breaking the sequence of recurrent ischemia leading to early cardiac events (Fig. 11). Secular trends in the care of cardiovascular patients predict even more sophisticated, invasive methods of treating coronary occlusion in the future. A futurist's view on this subject may envision the following type of scenario. A patient with prior CAD experiences persistent chest pain and notifies the emergency medical system. The paramedics arrive, and perform a rapid fingerstick cardiac biomarker panel and ECG. The results are interpreted by an emergency physician via a telecommunication system, and the patient is determined to be at high risk. He or she is triaged to a center capable of angioplasty and bypass surgery. On the way to the hospital, the patient is treated with aspirin, IV heparin, and an IV glycoprotein IIb/IIIa inhibitor. The patient undergoes triage angiography within 1 hour of hospital arrival, culprit lesion(s) are identified, and a revascularization plan is made--setting a critical pathway that is definitive. This vision is not far off on the horizon. We anticipate additional clinical trial results will help form the decision points in this optimal treatment scenario, which for a large proportion of patients will involve invasive management.
authors.affiliation: Cardiovascular Division, Henry Ford Hospital, Henry Ford Health System, Detroit, Michigan, USA. pmc@mich.com
authors.forename: P A
authors.initials: PA
authors.lastname: McCullough
authors.forename: W W
authors.initials: WW
authors.lastname: O'Neill
mesh_terms: D000789:Angina, Unstable / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary; D016001:Confidence Intervals; D017023:Coronary Angiography / Q000706:statistics & numerical data; D001026:Coronary Artery Bypass; D006801:Humans; D010818:Practice Patterns, Physicians'; D016032:Randomized Controlled Trials as Topic; D015912:Thrombolytic Therapy; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood; D014481:United States
chemical_list: D019210:Troponin I