title: [Radiation activation of angiotensin-converting enzyme during low-dose irradiation].
abstract: Radiation activation of angiotensin-converting enzyme (respect to Cbz-Phe-His-Leu as substrate) was obtained at the gamma (137Cs, t(irr) = 10s-2h, D approximately 3 Gy)- and X (plasma foces source, t(irr) = 10(-9)s, Cu-filter, D approximately 2 x 10(-5) Gy)-irradiation. The inactivation of the horseradish peroxidase at the same X-irradiation dose (2 x 10(-5) Gy) took place. Based on the experimental data and on the mathematical model proposed by us we made a conclusion that the special points exist on the dose response curves. Besides, the deduction that an activation is a common process at radiation changes of the different enzymes follows from our model. The activation of tobacco peroxidase (in presence of Ca(2+)-cations and without them) and of recombinant horseradish peroxidase (in presence of H2O2) by gamma-irradiation was really observed (respect to guaiacol as substrate).
authors.affiliation: Moscow State University, Chemistry Department.
authors.forename: M A
authors.initials: MA
authors.lastname: Orlova
authors.forename: O A
authors.initials: OA
authors.lastname: Kost
authors.forename: V A
authors.initials: VA
authors.lastname: Gribkov
authors.forename: I I
authors.initials: II
authors.lastname: Nikol'skaia
authors.forename: I V
authors.initials: IV
authors.lastname: Volobuev
authors.forename: N N
authors.initials: NN
authors.lastname: Troshina
authors.forename: V M
authors.initials: VM
authors.lastname: Fedoseev
mesh_terms: D000818:Animals; D002417:Cattle; D004789:Enzyme Activation; D005720:Gamma Rays; D006735:Horseradish Peroxidase / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism* / Q000528:radiation effects; D011829:Radiation Dosage; D013379:Substrate Specificity
chemical_list: D006735:Horseradish Peroxidase; D007703:Peptidyl-Dipeptidase A
vernacular_title: Radiatsionnaia aktivatsiia angiotenzin-prevrashchaiushchego fermenta pri malykh dozakh oblucheniia.