title: Concomitant use of intraaortic balloon counterpulsation and streptokinase in acute anterior myocardial infarction.
abstract: Using a prospective, nonrandomized design, the authors sought to determine whether concomitant use of intraaortic balloon counterpulsation (IABP) and streptokinase in acute anterior myocardial infarction (MI) would improve the in-hospital mortality rate and angiographic findings. The study included 45 patients with an acute anterior MI. All patients received intravenous streptokinase. Among these, 25 patients had concomitant IABP while the remaining 20 patients had streptokinase alone. All patients underwent cardiac catheterization. Patients treated with concomitant IABP had a significantly higher frequency of thrombolysis in myocardial infarction (TIMI) grade 3 flow (n: 11; 44% vs n: 1; 5%, p<0.05), and there was a trend toward a lower in-hospital mortality rate in the IABP group (n: 0; 0% vs n: 3; 15%, p=0.08). The angiographic presence of thrombus image and grade > or =2 coronary collateral circulation to the infarct-related coronary artery for the IABP and non-IABP groups did not differ significantly. The preliminary results of this study suggest that concomitant use of IABP and streptokinase in acute anterior MI increases the incidence of TIMI grade 3 flow and may have decreased the in-hospital mortality rate without unacceptable rates of vascular or hemorrhagic complications.
authors.affiliation: Department of Cardiology, Ankara University Medical School, Turkey.
authors.forename: S D
authors.initials: SD
authors.lastname: Kumbasar
authors.forename: E
authors.initials: E
authors.lastname: Semiz
authors.forename: O
authors.initials: O
authors.lastname: Sancaktar
authors.forename: S
authors.initials: S
authors.lastname: Yalçinkaya
authors.forename: C
authors.initials: C
authors.lastname: Ermiş
authors.forename: N
authors.initials: N
authors.lastname: Değer
mesh_terms: D006328:Cardiac Catheterization; D003097:Collateral Circulation / Q000187:drug effects / Q000502:physiology; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006406:Hematoma / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D015994:Incidence; D007262:Infusions, Intravenous; D007423:Intra-Aortic Balloon Pumping / Q000009:adverse effects / Q000379:methods; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*; D015996:Survival Rate; D015912:Thrombolytic Therapy
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase