Relationship between CD4+/CD8+ T cell ratio and T cell activation in systemic lupus erythematosus.
We investigated the relationship between the ratio of CD4+ to CD8+ T cells (CD4/CD8 ratio) and T cell activation, indicated by human leukocyte antigen (HLA)-DR expression, in patients with systemic lupus erythematosus (SLE). We found that the ratio was decreased in SLE patients and that this was significantly related to expression of HLA-DR by CD8+ (but not CD4+) T cells. These findings may assist in understanding the pathogenesis of SLE. In some SLE patients, the CD4/CD8 ratio and HLA-DR expression may be good indicators of therapeutic efficacy.
Maeda
N
N
Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan.
Sekigawa
I
I
Iida
N
N
Matsumoto
M
M
Hashimoto
H
H
Hirose
S
S
D000328:Adult; D016516:CD4-CD8 Ratio; D003108:Colonic Diseases / Q000188:drug therapy; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D007399:Interphase / Q000502:physiology; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000276:immunology*; D014456:Ulcer / Q000188:drug therapy
D006684:HLA-DR Antigens; D016572:Cyclosporine; D011239:Prednisolone