title: Effect of four enteral foods on the small bowel of undernourished rats after midgut resection.
abstract: OBJECTIVE
  To describe the effects of new enteral foods on the adaptation of the gut mucosa after massive intestinal resection in rats.
  
  
  METHODS
  Laboratory experiment.
  
  
  METHODS
  Teaching hospital, Spain.
  
  
  METHODS
  91 male Wistar rats, 69 of which were studied (5 were excluded and 17 died).
  
  
  METHODS
  Previously undernourished rats were subjected to either massive bowel resection (n = 30) or laparotomy (n = 26) and fed four enteral hypocaloric diets for 7 days: Alitraq (n = 7 in each group), Impact (n = 8 and 7), Enrich (n = 8 and 6), and Elemental (n = 7 and 6). The remainder were not operated on and fed chow (n = 7) or a diet containing no protein (n = 6). Two diets were high in protein (Alitraq and Impact) and two contained normal amounts (Enrich and Elemental).
  
  
  METHODS
  Bowel mucosal thickness and proliferation; disaccharidase activity; intestinal weight and length; body weight; and plasma somatostatin, IGF-1, and peptide YY concentrations.
  
  
  RESULTS
  Enriched diets provided a higher body and intestinal weight, and increased length of jejunal and ileal villous size. Peptide concentrations were modified by resection but not by the diet given. Concentrations of somatostatin and insulin-like growth factor were reduced in all groups with the exception of somatostatin in the two diets high in protein in the sham-operated rats.
  
  
  CONCLUSIONS
  Enriched diets all improve the intestinal adaptive response to massive bowel resection in rats, offering advantages over diets with normal amounts of protein.
authors.affiliation: Department of Experimental Surgery, Hospital La Paz, Madrid, Spain.
authors.forename: I A
authors.initials: IA
authors.lastname: Gómez de Segura
authors.forename: P
authors.initials: P
authors.lastname: Vázquez
authors.forename: P
authors.initials: P
authors.lastname: García
authors.forename: C G
authors.initials: CG
authors.lastname: Candela
authors.forename: A
authors.initials: A
authors.lastname: Cos
authors.forename: P G
authors.initials: PG
authors.lastname: Gancedo
authors.forename: J M
authors.initials: JM
authors.lastname: López
authors.forename: E
authors.initials: E
authors.lastname: De Miguel
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004186:Disaccharidases / Q000378:metabolism; D004195:Disease Models, Animal; D004750:Enteral Nutrition; D007413:Intestinal Mucosa / Q000503:physiopathology; D007421:Intestine, Small / Q000503:physiopathology* / Q000601:surgery; D007583:Jejunum / Q000503:physiopathology; D008297:Male; D009748:Nutrition Disorders / Q000503:physiopathology*; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000097:blood
chemical_list: D013004:Somatostatin; D004186:Disaccharidases