title: Expression of the optx2 homeobox gene during mouse development.
abstract: Optx2, a member of the sine oculis-Six family of homeobox genes, is first expressed in the anterior neural plate of the mouse embryo, and subsequently in the optic vesicle and ventral forebrain. During later development, expression is further restricted to precursors of the neural retina, optic chiasm, adenohypophysis and neurohypophysis. In the adult mouse retina, Optx2 mRNA is found in cells within the ganglion cell layer and inner nuclear layer.
authors.affiliation: Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: J
authors.initials: J
authors.lastname: Toy
authors.forename: O H
authors.initials: OH
authors.lastname: Sundin
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000032:analysis / Q000378:metabolism*; D051379:Mice; D012160:Retina / Q000196:embryology; D015534:Trans-Activators / Q000032:analysis / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; C114419:Six6 protein, mouse; D015534:Trans-Activators