Accelerated post-glucose glycaemia and altered alliesthesia-test in Seasonal Affective Disorder.
BACKGROUND
Little is known about the link between mood, food and metabolic function in Seasonal Affective Disorder (SAD).


METHODS
We investigated this link in a combined glucose tolerance-alliesthesia test in eight SAD patients in winter before and after one week light therapy, and in summer.


RESULTS
SAD patients exhibited faster post-glucose glycaemic and insulin responses (p <0.05), and increased hedonic ratings of high concentrated sucrose solutions (p <0.035) when depressed in winter than when euthymic (one week after light treatment or in summer).


CONCLUSIONS
The rapid glycaemic and insulin responses to an oral glucose load may be a result of accelerated gastric emptying.


CONCLUSIONS
The number of studied patients was rather small and no control group was studied in parallel.


CONCLUSIONS
the more rapid post-glucose glycaemia may impair glucose homeostasis in depressed SAD patients.
Kräuchi
K
K
Chronobiology and Sleep Laboratory, Psychiatric University Clinic, Basel, Switzerland. kraeuchik@ubaclu.unibas.ch
Keller
U
U
Leonhardt
G
G
Brunner
D P
DP
van der Velde
P
P
Haug
H J
HJ
Wirz-Justice
A
A
D000293:Adolescent; D000328:Adult; D000339:Affect; D001066:Appetite; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002153:Calorimetry, Indirect / Q000379:methods; D004040:Dietary Carbohydrates / Q000378:metabolism; D005260:Female; D005746:Gastric Emptying; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008297:Male; D010789:Phototherapy / Q000379:methods; D011446:Prospective Studies; D016574:Seasonal Affective Disorder / Q000097:blood* / Q000628:therapy; D013997:Time Factors
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin