title: [A case of synchronous multifocal urothelial tumors in a patient with phenacetin abuse].
abstract: A 79-year-old male with phenacetin abuse was admitted to our University Hospital for treatment of asymptomatic gross hematuria. Intravenous urograpdy and computed tomography revealed synchronous right renal pelvic carcinoma and bladder carcinoma. Right nephroureterectomy and transurethral resection of bladder tumor (TUR-Bt) were performed. Histologically, right renal pelvic tumor and bladder tumor were both transitional cell carcinomas of grade 2, pT1, and grade 1 = 2, Ta, respectively. Additionally, pathological examination revealed two distal ureteral tumors, which were transitional cell carcinomas of grade 2, pTa. He also had a history of heavy tobacco-smoking (20 cigarettes per day for 50 years). We discuss the relationship between transitional cell carcinoma and phenacetin abuse as well as the influence of tobacco-smoking, and review the literature.
authors.affiliation: Department of Urology, Institute of Clinical Medicine, University of Tsukuba.
authors.forename: M
authors.initials: M
authors.lastname: Onozawa
authors.forename: A
authors.initials: A
authors.lastname: Johraku
authors.forename: T
authors.initials: T
authors.lastname: Kojima
authors.forename: N
authors.initials: N
authors.lastname: Sekido
authors.forename: N
authors.initials: N
authors.lastname: Miyanaga
authors.forename: T
authors.initials: T
authors.lastname: Shimazui
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Takeshima
authors.forename: H
authors.initials: H
authors.lastname: Akaza
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000209:etiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology*; D007682:Kidney Pelvis; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D010615:Phenacetin; D012907:Smoking; D019966:Substance-Related Disorders / Q000150:complications*; D001749:Urinary Bladder Neoplasms / Q000209:etiology*
chemical_list: D010615:Phenacetin