title: Helicobacter pylori and apoptosis.
abstract: In an attempt to understand the diverse effects of infection with Helicobacter pylori on epithelial mucosal mass and consequent clinical outcome, the relationship between H. pylori infection and gastric epithelial cellular turnover has been investigated. Our results indicate that H. pylori increases epithelial cell proliferation and apoptosis in vivo, but that infection with bacteria of the cagA genotype leads to relatively more proliferation than apoptosis. This review explores the causes of the induction of apoptosis in gastric epithelial cells by H. pylori and the consequences of alterations in apoptosis to the maintenance of gastric mucosal homeostasis.
authors.affiliation: Department of Medicine, St. Luke's-Roosevelt Hospital Center/Columbia University, New York, New York 10025, USA. smoss1@pol.net
authors.forename: S F
authors.initials: SF
authors.lastname: Moss
mesh_terms: D000942:Antigens, Bacterial; D017209:Apoptosis; D001426:Bacterial Proteins / Q000378:metabolism; D002455:Cell Division; D004064:Digestive System / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D004848:Epithelium / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D016480:Helicobacter pylori / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori