title: Neurodevelopmental evaluation of 9-month-old infants exposed to low levels of lead in utero: involvement of monoamine neurotransmitters.
abstract: The objective of this work is to investigate the neurotoxicty of low-level lead exposure in utero on infants and the possible involvement of dopaminergic and serotonergic neurotransmitters. The correlation analysis for cord blood lead level, the concentrations of dopamine metabolite homovanillic acid (HVA) and serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cord plasma and the neurodevelopmental scales of infants were conducted on 244 9-month-old children. Both score of sociability subscale and 5-HIAA concentration were correlated with cord blood lead level. The sociability score was negatively correlated with the concentration of HVA, whereas both the coordination score and the global score were negatively correlated with the concentration of 5-HIAA. With partial correlation analysis, after taking HVA into account, the significant negative correlation between the sociability score and the cord blood lead level that existed in the linear correlation analysis disappeared, and the score of global scale correlated negatively with lead level in cord blood. When taking 5-HIAA into account, the scores of all the neurodevelopmental subscales except the language subscale were significantly negatively correlated with lead level in cord blood. The results indicated that low-level lead exposure in utero could produce a neurotoxic effect on the developing serotonergic system in infants. The neurotoxicity of low-level lead exposure in utero may affect the sociability of infants. Serotonergic activity was shown to have a potential effect on neurodevelopmental assessment. It may interfere with the association between low-level lead exposure in utero and other neurodevelopmental performances of 9-month-old children.
authors.affiliation: French National Institute of Medical Research and Health, Unit of Epidemiological Research, Villejuif. htang@chemdept.chem.ou.edu
authors.forename: H W
authors.initials: HW
authors.lastname: Tang
authors.forename: G
authors.initials: G
authors.lastname: Huel
authors.forename: D
authors.initials: D
authors.lastname: Campagna
authors.forename: G
authors.initials: G
authors.lastname: Hellier
authors.forename: C
authors.initials: C
authors.lastname: Boissinot
authors.forename: P
authors.initials: P
authors.lastname: Blot
mesh_terms: D015306:Biogenic Monoamines / Q000097:blood; D015331:Cohort Studies; D005260:Female; D005312:Fetal Blood / Q000187:drug effects / Q000378:metabolism; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D007223:Infant; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000097:blood*; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development; D009483:Neuropsychological Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013223:Statistics as Topic
chemical_list: D015306:Biogenic Monoamines; D007854:Lead; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid