title: Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
abstract: Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. The reactive versus neoplastic pathogenesis of this tumor is unresolved. We found clonal chromosome aberrations involving 2p23 upon metaphase analysis of two IMTs. Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 demonstrated rearrangement of the probe in both of these cases and in a third case, and immunohistochemistry revealed ALK expression in all three cases. 2p22-24 involvement has been reported previously in four additional cases of IMT. We suggest that chromosomal rearrangements involving 2p23 near or within ALK are recurrent alterations in IMT and that ALK may have a novel role outside its previously recognized realm of lymphoid neoplasms.
authors.affiliation: Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. cgriffin@jhmi.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Griffin
authors.forename: A L
authors.initials: AL
authors.lastname: Hawkins
authors.forename: C
authors.initials: C
authors.lastname: Dvorak
authors.forename: C
authors.initials: C
authors.lastname: Henkle
authors.forename: T
authors.initials: T
authors.lastname: Ellingham
authors.forename: E J
authors.initials: EJ
authors.lastname: Perlman
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D002648:Child; D002889:Chromosomes, Human, Pair 2; D015342:DNA Probes; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000235:genetics* / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis; D020794:Receptor Protein-Tyrosine Kinases
chemical_list: D015342:DNA Probes; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases