Avascular necrosis in patients treated with BEP chemotherapy for testicular tumours.
Avascular necrosis (AVN) is known to occur after combination chemotherapy for lymphomas and leukaemias that includes high dose corticosteroids, but it has been reported rarely in patients with solid tumours. We describe five recent cases in young men with testicular tumours (three of which were of good prognosis), who had been treated with chemotherapy using dexamethasone as an antiemetic. Dexamethasone is a low cost and effective antiemetic, but it may be responsible for inducing AVN in patients receiving chemotherapy for solid tumours. A prospective survey of the frequency of AVN is justified to quantify the extent of the problem.
Cook
A M
AM
Royal Marsden Hospital, Sutton, UK.
Patterson
H
H
Nicholls
J
J
Huddart
R A
RA
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003907:Dexamethasone / Q000009:adverse effects*; D005047:Etoposide / Q000008:administration & dosage; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D011859:Radiography; D013724:Teratoma / Q000188:drug therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy*
D000893:Anti-Inflammatory Agents; D001761:Bleomycin; D005047:Etoposide; D003907:Dexamethasone; D002945:Cisplatin