[Analysis of HLA-DRB1 allele in patients with chronic bronchitis].
OBJECTIVE
To study the difference in HLA-DRB1 allele frequencies between patients with simple chronic bronchitis and with coal worker's pneumoconiosis (CWP) complicated with chronic bronchitis.


METHODS
HLA-DRB1 allele frequencies were measured in 37 patients with simple chronic bronchitis and 33 with CWP complicated with chronic bronchitis of Han ethnicity in Shanxi Province using polymerase chain reaction with sequence specific primer, in comparison with those in normal population of the same province.


RESULTS
Allele frequency of HLA-DRB1 * 120X was 24.32% in those with simple chronic bronchitis, and that of HLA-DRB1 * 040X was 22.73% in those with CWP complicated with chronic bronchitis, significantly increased than that in normal people with both P < 0.01. There was no significant difference in other alleles between the three groups.


CONCLUSIONS
It suggests that in Han ethnicity of Shanxi Province HLA-DRB1 * 120X allele frequency is associated with simple chronic bronchitis and that of HLA-DRB1 * 040X is associated with CWP complicated with chronic bronchitis.
Peng
Z
Z
Department of Respiratory Diseases, Second Hospital of Shanxi Medical University, Taiyuan.
Li
J
J
Wang
C G
CG
D000483:Alleles; D001991:Bronchitis / Q000150:complications / Q000235:genetics*; D002908:Chronic Disease; D003032:Coal Mining; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D011009:Pneumoconiosis / Q000150:complications*; D016133:Polymerase Chain Reaction / Q000379:methods; D012494:Sampling Studies
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains