title: Prenatal diagnosis and perinatal management of fetal sacrococcygeal teratoma.
abstract: Sacrococcygeal teratoma is the most common fetal neoplasm, with an incidence of 1 in 40,000 births. Fetuses with this malformation are at risk for significant perinatal morbidity and mortality. We identified nine fetuses with sacrococcygeal teratomas that were diagnosed antenatally and managed at the University of North Carolina Hospitals over a 7-year period. We retrospectively reviewed the charts of mothers and infants and recorded data concerning perinatal and surgical management. Six infants survived the neonatal period. All infants diagnosed after 20 weeks' gestation survived. Fetal hydrops developed in three fetuses, all of whom died. Inadequate ventilation secondary to prematurity was a contributing factor in each lethal case. Diagnosis at an early gestational age, development of fetal hydrops, and premature delivery predicted a poor prognosis. When possible, we recommend that delivery be delayed to allow for fetal development. Stabilization of the infant should be attempted before resection of the teratoma.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Chisholm
authors.forename: A L
authors.initials: AL
authors.lastname: Heider
authors.forename: J A
authors.initials: JA
authors.lastname: Kuller
authors.forename: D
authors.initials: D
authors.lastname: von Allmen
authors.forename: M J
authors.initials: MJ
authors.lastname: McMahon
authors.forename: N C
authors.initials: NC
authors.lastname: Chescheir
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012445:Sacrococcygeal Region; D013125:Spinal Neoplasms / Q000151:congenital / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D013724:Teratoma / Q000151:congenital / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D016216:Ultrasonography, Prenatal