title: [The effect of cationic ferritin to the permeability of renal glomerular basement membrane and the mesangial area].
abstract: OBJECTIVE
  To study the effect of cationic ferritin (CF) to the permeability of the glomerular basement membrane (GBM) and the mesangial area.
  
  
  METHODS
  Single dose of CF 50mg/kg/rat given intravenously. Samples taken from the kidney were studied under electronic microscope by polyethylenimine (PEI) staining.
  
  
  RESULTS
  The number of PEI granules in GBM changed obviously while those in the mesangial matrix (MM) remained unchanged.
  
  
  CONCLUSIONS
  The negative charge in GBM serves as a charge barrier relating with proteinuria and the MM serves as the lymphatic pathway with no connection with proteinuria.
authors.affiliation: Department of Urology, 2nd Hospital, Dalian.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Shigeru
authors.forename: A
authors.initials: A
authors.lastname: Kaoru
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D002463:Cell Membrane Permeability; D005293:Ferritins / Q000493:pharmacokinetics*; D005920:Glomerular Mesangium / Q000378:metabolism* / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C010297:polycationic ferritin; D005293:Ferritins