Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines.
In this study we describe the results of experiments in which a variety of totally synthetic luteinizing hormone releasing hormone (LHRH) vaccines were assembled and examined for their abilities to elicit antibody responses and induce sterility in mice. It is shown that totally synthetic vaccines consisting of a 15 residue-defined T cell epitope and the 10 residue LHRH epitope not only induced high titers of antibody but also induced sterility. This effect did not appear to correlate with antibody titer, antibody isotype or comparative antibody affinity, but may be related to the length of time for which antibodies are present to exert their influence.
Ghosh
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Co-Operative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, University of Melbourne, Parkville 3052, Victoria, Australia.
Jackson
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D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D003269:Contraception, Immunologic / Q000379:methods*; D000939:Epitopes / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D013974:Thyroxine / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*
D000941:Antigens; D000939:Epitopes; D018984:Epitopes, T-Lymphocyte; D010455:Peptides; D014614:Vaccines, Synthetic; D007987:Gonadotropin-Releasing Hormone; D013974:Thyroxine