title: Design of scytalone dehydratase inhibitors as rice blast fungicides: derivatives of norephedrine.
abstract: Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
authors.affiliation: E.I. DuPont de Nemours Agricultural Products, Stine-Haskell Research Center, Newark, DE 19714, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Basarab
authors.forename: D B
authors.initials: DB
authors.lastname: Jordan
authors.forename: T C
authors.initials: TC
authors.lastname: Gehret
authors.forename: R S
authors.initials: RS
authors.lastname: Schwartz
authors.forename: Z
authors.initials: Z
authors.lastname: Wawrzak
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006836:Hydro-Lyases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D010665:Phenylpropanolamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D010935:Plant Diseases
chemical_list: D000935:Antifungal Agents; D010665:Phenylpropanolamine; D006836:Hydro-Lyases; C082741:scytalone dehydratase