title: Presumed ocular bartonellosis.
abstract: BACKGROUND
  The spectrum of diseases caused by Bartonella henselae continues to expand and ocular involvement during this infection is being diagnosed with increasing frequency.
  
  
  METHODS
  The clinical features and visual prognosis for 13 patients with intraocular inflammatory disease and laboratory evidence of bartonellosis were investigated. There were nine patients with neuroretinitis and four with panuveitis with positive antibody titres against B henselae determined by an enzyme immunoassay (IgG exceeding 1:900 and/or IgM exceeding 1:250).
  
  
  RESULTS
  Positive IgG levels were found for eight patients and positive IgM levels for five. Despite animal exposure of 10 patients, only two (IgG positive) cases had systemic symptoms consistent with the diagnosis of cat scratch disease. Pathological fluorescein leakage of the optic disc was observed in all affected eyes. At 6 months' follow up, 3/18 (17%) affected eyes had a visual acuity of less than 20/100, owing to optic disc atrophy and cystoid macular oedema. 12 patients (17 eyes) were treated with antibiotics; visual acuity improved two or more Snellen lines for 9/17 (53%) eyes.
  
  
  CONCLUSIONS
  The possibility of B henselae infection should be considered in patients with neuroretinitis and panuveitis (especially in cases with associated optic nerve involvement) even in the absence of systemic symptoms typical for cat scratch disease.
authors.affiliation: Department of Ophthalmology, FC Donders Institute, University Hospital Utrecht, Netherlands.
authors.forename: F T
authors.initials: FT
authors.lastname: Kerkhoff
authors.forename: J M
authors.initials: JM
authors.lastname: Ossewaarde
authors.forename: W S
authors.initials: WS
authors.lastname: de Loos
authors.forename: A
authors.initials: A
authors.lastname: Rothova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D018416:Bartonella henselae / Q000276:immunology; D002372:Cat-Scratch Disease / Q000175:diagnosis*; D002415:Cats; D004285:Dogs; D015818:Eye Infections, Bacterial / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D015864:Panuveitis / Q000382:microbiology; D012173:Retinitis / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M