Neural response of mechanoreceptors to acute inflammation in the rotator cuff of the shoulder joint in rabbits.
We examined with electrophysiological techniques the effects of experimentally induced inflammation on the mechanosensitive afferent units in the rotator cuff of the shoulder joint of 21 rabbits. We identified 21 mechanosensitive units belonging to group III. 12 units had mechanical thresholds of > 7.0 g and 9 units had thresholds of < 7.0 g. After injection of inflammatory agents, kaolin and carrageenan, into the joint space, ongoing afferent discharge rates increased in all units. The average discharge rate increased significantly from 7 imp/s to 15 imp/s after injection. 5 units had a decreased mechanical threshold after the injection. Acute inflammation seems to have an excitatory and sensitizing effect on the high- and low-threshold units in the rotator cuff.
Yamashita
T
T
Department of Orthopaedic Surgery, Sapporo Medical University, Japan. tyamasit@sapmed.ac.jp
Minaki
Y
Y
Takebayashi
T
T
Sakamoto
N
N
Ishii
S
S
D000208:Acute Disease; D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D002351:Carrageenan; D004195:Disease Models, Animal; D004594:Electrophysiology; D006801:Humans; D007249:Inflammation; D007616:Kaolin; D008297:Male; D008465:Mechanoreceptors / Q000503:physiopathology*; D011817:Rabbits; D017006:Rotator Cuff / Q000294:innervation*; D012684:Sensory Thresholds; D012785:Shoulder Joint / Q000294:innervation*; D052256:Tendinopathy / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*
D007616:Kaolin; D002351:Carrageenan