sox30: a novel zebrafish sox gene expressed in a restricted manner at the midbrain-hindbrain boundary during neurogenesis.
The Sox family of proteins is thought to act to regulate gene expression in a wide variety of developmental processes. Here we describe the cloning of sox30, a novel sox gene from the zebrafish (Danio rerio). In situ hybridization shows that sox30 is expressed in a restricted manner at the boundary between the midbrain and hindbrain during nervous system development. This expression pattern is in direct contrast to that of most other neuronally expressed Sox genes which are expressed throughout the nervous system.
De Martino
S P
SP
School of Biochemistry and Genetics, Catherine Cookson Building, Medical School, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.
Errington
F
F
Ashworth
A
A
Jowett
T
T
Austin
C A
CA
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D006609:High Mobility Group Proteins / Q000235:genetics*; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology / Q000378:metabolism; D010802:Phylogeny; D012313:RNA / Q000235:genetics / Q000378:metabolism; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D055749:SOXB2 Transcription Factors; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D015027:Zebrafish; D029961:Zebrafish Proteins
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D055749:SOXB2 Transcription Factors; D029961:Zebrafish Proteins; C119840:sox21a protein, zebrafish; D012313:RNA