[Amyloidosis. A review].
Amyloidosis is a heterogenous group of diseases, all characterized by extracellular deposition of amyloid either systemically or localized. Of wellknown diseases are Alzheimer's dementia, AL-amyloidosis (e.g. in multiple myeloma) and AA-amyloidosis (e.g. in rheumatoid arthritis). Amyloid is composed of three components of which the fibrillary component is the basis of amyloid classification. Many types of amyloid have a systemic distribution and give rise to varying symptoms. The diagnosis is based on biopsy, preferably of abdominal subcutis. The prognosis is poor, however, recent investigations on the three-dimensional structure of the P-component provide hope for future therapy.
Thomsen
J S
JS
Patologisk-anatomisk institut, Amtssygehuset i Herlev.
Horn
T
T
Schlichting
P
P
D000682:Amyloid / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D000686:Amyloidosis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D011379:Prognosis
D000682:Amyloid
Amyloidose. En oversigt.