title: Pharmacokinetics of ceftazidime in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections.
abstract: The pharmacokinetics of ceftazidime in yearling loggerhead sea turtles (Caretta caretta) following single i.m and i.v. injections were studied. Eight juvenile 1.25+/-0.18 kg turtles were divided into two groups. Four animals received 20 mg/kg of ceftazidime i.v. and four received the same dose i.m. Plasma ceftazidime concentrations were analyzed by reverse-phase high-performance liquid chromatography. The i.v. and i.m. administration half-lives were 20.59+/-3.24 hr and 19.08+/-0.77 hr, respectively. The volume of distribution was 0.42+/-0.07 L/kg, and the systemic clearance was 0.217+/-0.005 ml/min/kg. Ceftazidime was detected in all blood samples and its concentration exceeded the minimum inhibitory concentration for Pseudomonas for 60 hr after i.m. and i.v. injections.
authors.affiliation: Environmental Medicine Consortium, North Carolina State University, Raleigh 27606, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Stamper
authors.forename: M G
authors.initials: MG
authors.lastname: Papich
authors.forename: G A
authors.initials: GA
authors.lastname: Lewbart
authors.forename: S B
authors.initials: SB
authors.lastname: May
authors.forename: D D
authors.initials: DD
authors.lastname: Plummer
authors.forename: M K
authors.initials: MK
authors.lastname: Stoskopf
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002442:Ceftazidime / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D014426:Turtles / Q000378:metabolism*
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime