title: [The influence of ozone therapy on endothelial damage markers in patients with atherosclerosis of lower extremities].
abstract: The aim of study was to evaluate the influence of the treatment with oxygen-ozone mixture on the blood plasma antigen concentration of tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) in patients suffering from atherosclerotic disease of lower extremities. The study was performed in the group of 28 (M/F 22/6) patients means aged 64.1 years with atherosclerotic diseases of lower extremities, in whom 2 weeks therapy with oxygen-ozone mixture was used. The control group consisted of 30 healthy volunteers in mean age 51.0 years. In the blood plasma obtained from the patients before and after treatment with oxygen-ozone mixture and from the control group determinations of t-PA and vWF antigen using ELISA were done. Both parameters were significantly increased in the patients before the treatment in comparison to the healthy controls. The treatment with oxygen-ozone therapy caused in patients slight statistically not significant raise of t-PA and vWF antigen showing the endothelial stimulation but not the destruction of vascular endothelium.
authors.affiliation: Katedry i Zakładu Patofizjologii, Akademii Medycznej w Bydgoszczy.
authors.forename: D
authors.initials: D
authors.lastname: Rość
authors.forename: I
authors.initials: I
authors.lastname: Ponikowska
authors.forename: R
authors.initials: R
authors.lastname: Paczuski
authors.forename: K
authors.initials: K
authors.lastname: Włodarczyk
authors.forename: E
authors.initials: E
authors.lastname: Zastawna
authors.forename: A
authors.initials: A
authors.lastname: Michalski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000097:blood; D001161:Arteriosclerosis / Q000473:pathology* / Q000628:therapy*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007866:Leg / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000494:pharmacology / Q000627:therapeutic use; D010126:Ozone / Q000494:pharmacology / Q000627:therapeutic use*; D016491:Peripheral Vascular Diseases / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000187:drug effects; D014841:von Willebrand Factor
chemical_list: D000941:Antigens; D014841:von Willebrand Factor; D010126:Ozone; D010959:Tissue Plasminogen Activator; D010100:Oxygen
vernacular_title: Wpływ ozonoterapii na wskaźniki uszkodzenia śródbłonka naczyniowego u chorych na miazdzyce zarostowa.