title: Molecular biology for the critical care physician. Part II: where are we now?
abstract: The extraordinary technical developments in molecular biology are having a profound impact in clinical medicine. The contribution of recombinant DNA technology in defining the molecular pathology of common disorders and of diagnostic molecular techniques for detection of infectious organisms are used as examples to demonstrate the clinical relevance of these developments. Finally, the potential use of DNA as a therapeutic drug (gene therapy) is addressed.
authors.affiliation: Department of Respiratory Medicine & Allergy, Guy's King's and St Thomas's School of Medicine, Guy's Hospital, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Santis
authors.forename: T W
authors.initials: TW
authors.lastname: Evans
mesh_terms: D003422:Critical Care; D018014:Gene Transfer Techniques; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing / Q000379:methods; D015316:Genetic Therapy / Q000379:methods; D005826:Genetics, Medical / Q000379:methods / Q000639:trends; D006801:Humans; D008967:Molecular Biology / Q000379:methods / Q000639:trends; D011110:Polymorphism, Genetic / Q000235:genetics