title: Towards an objectification by classification of tinnitus.
abstract: OBJECTIVE
  The objectives of this study are to identify the presence of tinnitus and classify its different forms, in terms of changes in noise.
  
  
  METHODS
  Late auditory evoked responses (LAERs) were recorded from Fz in response to 1000 Hz tone bursts of various intensities, in 13 tinnitus-free subjects and in 25 tinnitus sufferers (16 bilateral and 9 unilateral tinnitus sufferers). A classification of different forms of tinnitus, in terms of changes in noise, was also undertaken. N1-P2 component amplitudes and N1 and P2 latencies were measured.
  
  
  RESULTS
  Objective identification of the affected ear in unilateral tinnitus sufferers was found feasible on the basis of N1-P2 intensity-dependence and N1-P2 amplitude. The bilateral tinnitus group was found to differ from controls by greater intensity-dependence of the N1-P2 component and shorter N1 latency. These characteristics varied with tinnitus type: a classification on the basis of intensity-dependence and latencies proved feasible. The group of patients showing improved tinnitus in noise had greater intensity-dependence and longer N1 latency than did the group showing aggravated tinnitus in noise.
  
  
  CONCLUSIONS
  Data are discussed in light of the inhibitory role of frontal cortex on the sensory inputs and the modulatory function of central serotonergic system on the processing of auditory information.
authors.affiliation: Laboratoire Neurosciences et Systèmes Sensoriels CNRS UPRESA 5020, Hôpital Edouard Herriot, Lyon, France. anorena@olfac.univ-lyon1.fr
authors.forename: A
authors.initials: A
authors.lastname: Norena
authors.forename: H
authors.initials: H
authors.lastname: Cransac
authors.forename: S
authors.initials: S
authors.lastname: Chéry-Croze
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D014012:Tinnitus / Q000503:physiopathology*