title: Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle?
abstract: Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that have to interact with mucosa and/or cellular barriers for their life cycles to progress. Even though they both give rise to dramatically different diseases, the use of in vitro models has shown that most of the mechanisms mediating cellular interactions are common to N. meningitidis and N. gonorrhoeae. This suggests that bacterial cell interactions may be essential not only for pathogenesis but also for other aspects of the bacterial life cycle that are common to both N. meningitidis and N. gonorrhoeae. This manuscript will review the most recent developments concerning the mechanisms mediating cellular interaction of pathogenic Neisseria and will then try to put them into the perspective of pathogenesis and bacterial life cycle.
authors.affiliation: INSERM U411, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France. nassif@necker.fr
authors.forename: X
authors.initials: X
authors.lastname: Nassif
authors.forename: C
authors.initials: C
authors.lastname: Pujol
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.forename: E
authors.initials: E
authors.lastname: Eugène
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000502:physiology; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000472:pathogenicity / Q000502:physiology*; D009345:Neisseria meningitidis / Q000472:pathogenicity / Q000502:physiology*; D018933:Pili, Sex / Q000502:physiology; D018272:Porins / Q000502:physiology
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D018272:Porins; C050308:opacity proteins; C074517:opc protein, bacteria; C090348:Opa protein, Neisseria