DNA recombination: the replication connection.
Chromosomal double-strand breaks (DSBs) arise after exposure to ionizing radiation or enzymatic cleavage, but especially during the process of DNA replication itself. Homologous recombination plays a critical role in repair of such DSBs. There has been significant progress in our understanding of two processes that occur in DSB repair: gene conversion and recombination-dependent DNA replication. Recent evidence suggests that gene conversion and break-induced replication are related processes that both begin with the establishment of a replication fork in which both leading- and lagging-strand synthesis occur. There has also been much progress in characterization of the biochemical roles of recombination proteins that are highly conserved from yeast to humans.
Haber
J E
JE
Brandeis University, Waltham, MA 02454-9110, USA.
D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D005785:Gene Conversion; D006801:Humans; D011995:Recombination, Genetic