Nucleotide sequence of equine caspase-1 cDNA.
Caspases are a family of cysteine proteases which have important roles in activation of cytokines and in apoptosis. Caspase-1, or interleukin-1 beta converting enzyme (ICE), promotes maturation of interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. We report the cloning and sequencing of equine caspase-1 cDNA. Equine caspase-1 is 405 amino acids in length and has 72% and 63% identity to human and mouse caspase-1, respectively, at the amino acid level. Sites of proteolytic cleavage and catalytic activity as identified in human caspase-1, are conserved.
Wardlow
S
S
Department of Veterinary Pathology, University of Glasgow Veterinary School, UK.
Penha-Goncalves
M N
MN
Argyle
D J
DJ
Onions
D E
DE
Nicolson
L
L
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D020170:Caspase 1 / Q000235:genetics*; D018076:DNA, Complementary; D018397:Equidae; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data
D018076:DNA, Complementary; D020170:Caspase 1