Noradrenaline release in the locus coeruleus of conscious rats is triggered by drugs, stress and blood pressure changes.
The in vivo release of noradrenaline (NA) in the locus coeruleus (LC) of conscious rats was enhanced by local superfusion of pargyline, idazoxan, bicuculline, AMPA as well as by experimentally induced hypotension. Noise stress considerably enhanced NA release in the LC and this response was promoted after local alpha2-adrenoceptor blockade by idazoxan. Air jet stress and noise stress elicited comparable increases in NA release in the LC and the simultaneously superfused amygdala. The NA responses in both areas did not change during a second exposure to each of the stressors. It is concluded that NA release at the somatodendritic level of LC neurons is triggered by high LC activity and most likely serves to limit LC activation to excitatory stimuli by feedback inhibition via alpha2-adrenoceptors.
Singewald
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N
Department of Pharmacology and Toxicology, University of Innsbruck, Austria.
Kaehler
S T
ST
Philippu
A
A
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology*; D019329:Idazoxan / Q000494:pharmacology; D008125:Locus Coeruleus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000378:metabolism*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D010293:Pargyline; D009638:Norepinephrine; D019329:Idazoxan; D001640:Bicuculline