Histological and electron-microscopic observations on the mucosa of pediculated duodenal wall graft transplanted to the stomach in Wistar rats.
OBJECTIVE
To study the mechanism of gastric metaplasia in duodenum through the transplantation of a flap of duodenal wall with vascular pedicle to the stomach.


METHODS
The pediculated duodenal wall flaps of Wistar rats were transplanted to their stomachs. The rats were killed at the 3rd, 6th, 9th and 12th month after the operation respectively, and histological changes of the duodenal grafts were observed with optical and electron microscopy.


RESULTS
Gastric metaplasia was found in the mucosa of duodenal grafts transplanted to the stomach at the 6th, 9th and 12th month.


CONCLUSIONS
The formation of gastric metaplasia in the duodenal mucosa may be related to a change of the microenvironment around the tissues, and duodenal mucosa may differentiate into gastric epithelium by the decrease of pH value.
Li
C
C
Department of Gastroenterology, Air Force General Hospital, Beijing, China.
Wang
J
J
Zhang
X
X
D000818:Animals; D004195:Disease Models, Animal; D004378:Duodenal Diseases / Q000473:pathology; D004386:Duodenum / Q000637:transplantation* / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000473:pathology; D007413:Intestinal Mucosa / Q000648:ultrastructure*; D008297:Male; D008679:Metaplasia; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000601:surgery*