title: Binding of chlorpheniramine enantiomers to human plasma proteins.
abstract: The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and alpha-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38% vs. 23%), to albumin (20% vs. 15%) and to alpha-glycoprotein acid (23% vs. 5%).
authors.affiliation: Pitié Salpêtrière Hospital Pharmacy, Paris, France.
authors.forename: B T
authors.initials: BT
authors.lastname: Hiep
authors.forename: F
authors.initials: F
authors.lastname: Gimenez
authors.forename: V U
authors.initials: VU
authors.lastname: Khanh
authors.forename: N K
authors.initials: NK
authors.lastname: Hung
authors.forename: A
authors.initials: A
authors.lastname: Thuillier
authors.forename: R
authors.initials: R
authors.lastname: Farinotti
authors.forename: C
authors.initials: C
authors.lastname: Fernandez
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D002744:Chlorpheniramine / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D066298:In Vitro Techniques; D009961:Orosomucoid / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D001798:Blood Proteins; D009961:Orosomucoid; D012709:Serum Albumin; D002744:Chlorpheniramine