Young age as a prognostic factor in cervical cancer: results of a population-based study.
OBJECTIVE
Our goal was to use population-based data to determine the difference in 5-year survival in women diagnosed with cervical cancer between those aged 18-34 years and those aged 40-60 years.


METHODS
The SEER (Surveillance, Epidemiology, and End Results) public-use database, 1973-1994, was used for this investigation. Only subjects with cervical carcinoma diagnosed between 1988 and 1990 were included. Subjects were stratified on age at diagnosis (<35 years or 40-60 years), clinical stage, histologic type, race-ethnicity, and grade.


RESULTS
Two thousand cases of invasive cervical cancer were identified. The younger subgroup of patients was diagnosed with earlier-stage disease more frequently than the older group (P =.0001). When adjustments were made for non-cervical cancer causes of death, there was no difference in 5-year survival between the 2 cohorts. African American women had a poorer 5-year survival (P =.02)


CONCLUSIONS
There was no overall difference in survival between the 2 cohorts when appropriate adjustments were made for cause of death and for stage, histologic type, and grade of disease.
Brewster
W R
WR
Division of Gynecologic Oncology, University of California Irvine Medical Center, California, USA.
DiSaia
P J
PJ
Monk
B J
BJ
Ziogas
A
A
Yamada
S D
SD
Anton-Culver
H
H
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044383:Black People; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D044469:Racial Groups; D018426:SEER Program; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology; D001741:Black or African American