title: In vitro activities of the everninomicin SCH 27899 and other newer antimicrobial agents against Borrelia burgdorferi.
abstract: The in vitro activity of the everninomicin antibiotic SCH 27899 against 17 isolates of Borrelia spp. was investigated. MICs ranged from 0.06 to 0.5 microg/ml. Time-kill studies with the B31 strain of B. burgdorferi demonstrated >/=3-log10-unit killing after 72 h with concentrations representing four times the MIC. The in vitro activity of four other newer antimicrobial agents, meropenem, cefepime, quinupristin-dalfopristin, and linezolid, was also tested against the B31 strain. Meropenem was the most potent of the latter agents, with an MIC of 0.125 microg/ml.
authors.affiliation: Medical Service, Veterans Affairs New Jersey Health Care System, East Orange, New Jersey 07018, USA. dever.lisa@east-orange.va.gov
authors.forename: L L
authors.initials: LL
authors.lastname: Dever
authors.forename: C V
authors.initials: CV
authors.lastname: Torigian
authors.forename: A G
authors.initials: AG
authors.lastname: Barbour
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D002443:Ceftriaxone / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013845:Thienamycins; C001202:evernimicin; D002443:Ceftriaxone; D000077731:Meropenem; D004318:Doxycycline