title: Atrial septal defect in Malta.
abstract: OBJECTIVE
  To study diagnostic and surgical trends in atrial septal defect (ASD) in a population-based study, and estimate birth prevalence and spontaneous closure rates.
  
  
  METHODS
  All patients in Malta diagnosed as having ASD and born between 1990 and 1994 were identified from various sources. This took place in the setting of a regional hospital supplying diagnostic services for the entire population. Echocardiographic follow-up was also undertaken for lesions not requiring intervention.
  
  
  RESULTS
  A total of 190 patients born in this period were diagnosed as having ASD. Age at diagnosis and age at surgery have decreased significantly over the period under study (P < 0.0001). The mode of diagnosis has become entirely noninvasive, and the perioperative mortality decreased dramatically over time. For the period 1990-94, the incidence at birth for defects not requiring intervention was 2.0/1000 live births, defects requiring intervention 0.4/1000 live births. A total of 92% of 50 defects not requiring intervention closed spontaneously, and the remainder had spontaneously decreased in size on follow-up.
  
  
  CONCLUSIONS
  ASD is a relatively benign malformation in which early and noninvasive diagnosis can be achieved, with an extremely low interventional mortality.
authors.affiliation: Paediatric Department, St. Luke's Hospital, Guardamangia, Malta. vgrech@mail.link.net.mt
authors.forename: V
authors.initials: V
authors.lastname: Grech
mesh_terms: D006348:Cardiac Surgical Procedures / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology; D006344:Heart Septal Defects, Atrial / Q000175:diagnosis* / Q000453:epidemiology* / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008319:Malta / Q000453:epidemiology; D015995:Prevalence; D012075:Remission, Spontaneous; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate