Cytoskeleton cross-talk during cell motility.
Cell crawling entails the co-ordinated creation and turnover of substrate contact sites that interface with the actin cytoskeleton. The initiation and maturation of contact sites involves signalling via the Rho family of small G proteins, whereas their turnover is under the additional influence of the microtubule cytoskeleton. By exerting relaxing effects on substrate contact assemblies in a site- and dose-specific manner, microtubules can promote both protrusion at the front and retraction at the rear, and thereby control cell polarity.
Small
J V
JV
Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg. jvsmall@imb.oeaw.ac.at
Kaverina
I
I
Krylyshkina
O
O
Rottner
K
K
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D008870:Microtubules / Q000502:physiology