Unusual clinical presentation in a patient with myelodysplastic syndrome, with subsequent hematological remission and suppression of the malignant clone following treatment with cyclosporine A, erythropoietin and granulocyte colony-stimulating factor.
A 35-year-old female presented with isolated thrombocytopenia of autoimmune origin. One and a half years later, hypoplastic myelodysplastic (MDS) was diagnosed. Following treatment with cyclosporin A, erythropoietin and granulocyte colony-stimulating factor, the patient has achieved a sustained hematological remission which is still ongoing after 3 years. Furthermore, to the best of our knowledge, this is the third case described in the literature where treatment with cytokines alone or in combination with immunosuppressive agents has resulted in a long standing cytogenetic response in MDS.
Samuelsson
J
J
Department of Hematology, The Karolinska Institute at Huddinge University Hospital, Sweden. jan.samuelsson@hematol.hs.sll.se
Lärfars
G
G
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000473:pathology; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000188:drug therapy* / Q000473:pathology; D010976:Platelet Count / Q000187:drug effects; D012074:Remission Induction / Q000379:methods; D013921:Thrombocytopenia / Q000188:drug therapy / Q000473:pathology
D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D016572:Cyclosporine