[Synthesis and antiproliferative activity of a novel N-acyl derivative of doxorubicin].
Doxorubicin was acylated with estrone 3-hemisuccinate. The modified derivative exhibited high antiproliferative activity in vitro toward cell cultures of the MCF-7 human mammary adenocarcinoma and HepG2 human hepatoma.
Shcherbakov
V M
VM
Institute of Biological Medicine, Moscow, Russia.
Devichenskiĭ
V M
VM
Vorontsov
E A
EA
Kuznetsov
S L
SL
Kriukov
L N
LN
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C120001:estrone-3-hemisuccinate-doxorubicin; D004317:Doxorubicin
Sintez i antiproliferativnaia aktivnost' novogo N-atsil'nogo proizvodnogo doksorubitsina.