Granulocyte colony-stimulating factor-producing primary pericardial mesothelioma.
A 54-year-old male patient presented with a granulocyte colony-stimulating factor (G-CSF)-producing primary pericardial mesothelioma, while showing symptoms of congestive heart failure, a fever of 38 to 39 degrees C, and marked leucocytosis of 52.7 x 10(3) cells/mm3. The histopathologic diagnosis was established after autopsy. G-CSF production was confirmed by the expression of G-CSF mRNA in the tumor extract and the patient's high serum G-CSF concentration. The expression of G-CSF by benign and malignant mesothelial cells has already been reported. However, this is the first case report of G-CSF production in a pericardial mesothelioma.
Horio
H
H
Department of Thoracic Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Nomori
H
H
Morinaga
S
S
Kikuchi
T
T
Tomonari
H
H
Kuriyama
S
S
Suemasu
K
K
D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D006338:Heart Neoplasms / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D010496:Pericardium; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; D016179:Granulocyte Colony-Stimulating Factor