title: Maternal fertility is not affected by fetal surgery.
abstract: The purpose of this report is to assess the impact of fetal surgery on future maternal fertility, subsequent pregnancy outcome, and the incidence of pregnancy complications. Retrospective data were collected on 70 mothers who underwent fetal surgery between April 1981 and June 1996. Indications for open hysterotomy fetal surgery included congenital diaphragmatic hernia (n = 44), congenital cystic adenomatoid malformation of the lung (n = 11), urinary obstruction (n = 9), sacrococcygeal teratoma (n = 4), heart block (n = 1), and acardiac-acephalic twin reduction (n = 1). The following data were obtained: number of pregnancy attempts, number of successful pregnancies, pregnancy outcome including obstetrical and neonatal complications, and infertility after fetal surgery. There were 45 respondents, of whom 35 attempted subsequent pregnancies. Thirty-two were successful, resulting in 31 livebirths. Two women had a strong prefetal surgery history of infertility, 1 has only attempted to conceive for 3 months. We report this experience because the effect of open fetal surgery on futrue fertility is such an important question for our patients and referring physicians. This analysis suggests that hysterotomy and open fetal surgery has a negligible impact on maternal fertility.
authors.affiliation: Department of Surgery, Division of Pediatric Surgery, Fetal Treatment Center, University of California, San Francisco, Calif., USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Farrell
authors.forename: C T
authors.initials: CT
authors.lastname: Albanese
authors.forename: R W
authors.initials: RW
authors.lastname: Jennings
authors.forename: S J
authors.initials: SJ
authors.lastname: Kilpatrick
authors.forename: B J
authors.initials: BJ
authors.lastname: Bratton
authors.forename: M R
authors.initials: MR
authors.lastname: Harrison
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005298:Fertility; D005333:Fetus / Q000601:surgery*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012189:Retrospective Studies