[Distribution of fibronectin in kidney of IgA nephropathy and its clinicopathological correlation].
To understand of fibronectin (Fn) distribution in kidney of IgA nephropathy (IgAN) and their meaning, we studied 107 cases of IgAN. Strong positive staining of Fn was shown in mesangial areas with proliferation, crescents, segmental sclerosis, and sclerosing glomeruli. 33 patients (group M) had Fn distributed only in mesangium, and 74 (group B) had Fn along the capillary walls as well as mesangium. Compared with those in group M, patients in group B showed more severe renal histological lesions (P < 0.01), crescent formation and stronger staining of IgG, C3 (P < 0.05) and IgA (P < 0.01) along the capillary walls. More severe changes of GBM were found in group B under electron microscopy. Clinically, 24th protein excretion (P < 0.01), incidences of hypertension and nonselective proteinuria were significantly higher (0.01 < P < 0.05), and Ccr was lower (0.01 < P < 0.05) in group B. 44 patients were followed up for 19.2 months, and the incidence of renal function deterioration in group B increased much more (0.01 < P < 0.05) than that in group M. Our results dmonstrated that the increase of Fn along the golmerular capillary walls might reflect that excessive proliferation of mesangial matrix, severe immune injury in capillary wall and damage of GBM, which are correlated with unfavorable clinical features and progression of the disease.
Shi
Y
Y
Department of Nephrology, Nan Fang Hospital, Guangzhou.
Li
L
L
Zhou
H
H
D000328:Adult; D002196:Capillaries / Q000378:metabolism; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000378:metabolism; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D008297:Male
D005353:Fibronectins; D007070:Immunoglobulin A; D007074:Immunoglobulin G