title: Effect of Q10 supplementation on tissue Q10 levels and adenine nucleotide catabolism during high-intensity exercise.
abstract: The aim of the present study was to investigate the concentration of ubiquinone-10 (Q10), at rest, in human skeletal muscle and blood plasma before and after a period of high-intensity training with or without Q10 supplementation. Another aim was to explore whether adenine nucleotide catabolism, lipid peroxidation, and mitochondrial function were affected by Q10 treatment. Seventeen young healthy men were assigned to either a control (placebo) or Q10-supplementation (120 mg/day) group. Q10 supplementation resulted in a significantly higher plasma Q10/total cholesterol level on Days 11 and 20 compared with Day 1. There was no significant change in the concentration of Q10 in skeletal muscle or in isolated skeletal muscle mitochondria in either group. Plasma hypoxanthine and uric acid concentrations increased markedly after each exercise test session in both groups. After the training period, the postexercise increase in plasma hypoxanthine was markedly reduced in both groups, but the response was partially reversed after the recovery period. It was concluded that Q10 supplementation increases the concentration of Q10 in plasma but not in skeletal muscle.
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institute, Box 5626, S-114 86 Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Svensson
authors.forename: C
authors.initials: C
authors.lastname: Malm
authors.forename: M
authors.initials: M
authors.lastname: Tonkonogi
authors.forename: B
authors.initials: B
authors.lastname: Ekblom
authors.forename: B
authors.initials: B
authors.lastname: Sjödin
authors.forename: K
authors.initials: K
authors.lastname: Sahlin
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D015444:Exercise / Q000502:physiology*; D006801:Humans; D019271:Hypoxanthine / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D018482:Muscle, Skeletal / Q000737:chemistry / Q000648:ultrastructure; D010101:Oxygen Consumption; D010919:Placebos; D014451:Ubiquinone / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000227:Adenine Nucleotides; D010919:Placebos; D014451:Ubiquinone; D014810:Vitamin E; D014527:Uric Acid; D019271:Hypoxanthine; D008315:Malondialdehyde; D000255:Adenosine Triphosphate; D002784:Cholesterol; C025204:Ubiquinone Q2