title: Dissociation of pituitary-adrenal and catecholamine activation after induced cardiac arrest and defibrillation.
abstract: To avoid factors which confound attempts to characterize the neuroendocrine response to cardiac arrest, we studied the pituitary-adrenocortical and catecholamine responses to induced ventricular fibrillation (VF) and direct current cardioversion in 10 patients undergoing testing of 'implanted cardioverter defibrillator' devices under sedation. Plasma concentrations of epinephrine were increased 5 min after VF (from a mean basal of 0.39 (S.E.M. 0.09) to a peak of 0.632 (0.212) nmol litre-1; P < 0.05) but were unchanged at other times. Plasma concentrations of norepinephrine did not change at any time. Plasma concentrations of cortisol increased significantly at 10 min (from a mean of 367 (SEM 62) to 539 (64) nmol litre-1; P < 0.001) and remained increased 30 min after VF (470 (74) nmol litre-1; P < 0.05) but had returned towards baseline at 60 min, whereas plasma prolactin concentrations were increased at 5 min (from a mean of 224 (SEM 54) to 320 (63) mu. litre-1; P < 0.01) and remained increased until the end of the sampling period at 60 min (288 (65) mu. litre-1; P < 0.05). Concentrations of adrenocorticotrophic hormone (ACTH) (n = 5) tended to increase but this was not statistically significant. We conclude that a short period of cardiac arrest in lightly sedated humans activated the pituitary-adrenocortical axis but did not appear to stimulate catecholamine secretion. These findings raise questions about the nature and mechanisms of the neuroendocrine response to cardiac arrest.
authors.affiliation: Department of Intensive Care, St Bartholomew's Hospital, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Leary
authors.forename: A C
authors.initials: AC
authors.lastname: Timmins
authors.forename: J N
authors.initials: JN
authors.lastname: Appleby
authors.forename: S
authors.initials: S
authors.lastname: Medbak
authors.forename: A B
authors.initials: AB
authors.lastname: Grossman
authors.forename: A W
authors.initials: AW
authors.lastname: Nathan
authors.forename: C J
authors.initials: CJ
authors.lastname: Hinds
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D004554:Electric Countershock; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006323:Heart Arrest / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011388:Prolactin / Q000097:blood
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine