Transdermal nicotine: single dose effects on mood, EEG, performance, and event-related potentials.
A 21-mg dose of nicotine was administered transdermally to 16 overnight smoking-deprived smokers in a double-blind, placebo-controlled design. Mood ratings, electroencephalography (EEG), behavioral performance and event-related potential (ERP: P300) indices of attention and information processing speed were assessed before and 4 h after placebo/nicotine treatment. Although nicotine, relative to placebo, failed to alter mood, it increased absolute and relative power indices of EEG arousal, shortened reaction times, and increased P300 amplitudes. The results are discussed in relation to nicotine's actions on cholinergic transmission and its role in smoking behavior.
Knott
V
V
Department of Psychiatry, University of Ottawa/Royal, Ottawa Hospital and Institute of Mental Health Research, Ontario, Canada.
Bosman
M
M
Mahoney
C
C
Ilivitsky
V
V
Quirt
K
K
D000279:Administration, Cutaneous; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects*; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D012907:Smoking / Q000503:physiopathology / Q000523:psychology
D009538:Nicotine