Signal transduction from the B cell antigen-receptor.
Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).
Campbell
K S
KS
Fox Chase Cancer Center, Institute for Cancer Research, Division of Basic Science, 7701 Burholme Avenue, Philadelphia, PA 19111, USA. ksvcampbell@fccc.edu.
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D020690:GTPase-Activating Proteins; D006801:Humans; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology* / Q000502:physiology; D018631:ras Proteins / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; C113939:B cell linker protein; D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D010750:Phosphoproteins; D011947:Receptors, Antigen, B-Cell; C085379:rho GTPase-activating protein; D019869:Phosphatidylinositol 3-Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019204:GTP-Binding Proteins; D018631:ras Proteins