[Virological response to interferon therapy in patients dually infected with TT virus and hepatitis C virus].
In 30 chronic hepatitis C patients co-infected with TTV, TTV DNA in the sera immediately after cessation of IFN and 6 months after the end of IFN was examined. Sustained loss of TTV DNA was observed in 12 of 30 (40.0%) patients. In 7 of 30 (23.3%) patients, TTV DNA re-appeared 6 months after becoming undetectable at the end of IFN therapy. In the remaining 11 patients (36.7%), TTV DNA remained detectable during the entire follow-up period. The ALT values correlated only with the presence of HCV RNA regardless of the effect of IFN on TTV replication. This study indicates that IFN therapy is effective against TTV.
Matsumoto
H
H
Dept. of Gastroenterology, Mito Kyodo General Hospital.
Araki
M
M
Kakinuma
K
K
Kawamata
O
O
Yamauchi
T
T
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D004267:DNA Viruses; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000628:therapy*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000628:therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D016898:Interferon-alpha