Matrix metalloproteinase-1 expression is a prognostic factor for patients with advanced gastric cancer.
Proteolytic activity of cancer cells is an important factor in metastasis. This study examined the relationship between MMP-1 expression of gastric cancer cells and peritoneal metastasis. MMP-1 expression was found in 76/103 (75.2%) cases examined and was significantly associated with both peritoneal metastasis and lymph node metastasis (p<0.05, respectively). The prognosis of patients with MMP-1 positive tumor was significantly worse than that of patients with MMP-1 negative tumor (p<0.05). These findings suggested that MMP-1 might be a prognostic factor in case of advanced gastric cancer and might be useful in determining whether or not adjuvant therapy was indicated for patients at high risk of peritoneal recurrence.
Inoue
T
T
First Department of Surgery, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
Yashiro
M
M
Nishimura
S
S
Maeda
K
K
Sawada
T
T
Ogawa
Y
Y
Sowa
M
M
Chung
K H
KH
D000328:Adult; D000368:Aged; D017364:Collagenases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D020781:Matrix Metalloproteinase 1; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010534:Peritoneal Neoplasms / Q000201:enzymology / Q000556:secondary; D011379:Prognosis; D012008:Recurrence; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology
D017364:Collagenases; D020781:Matrix Metalloproteinase 1