title: Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension.
abstract: Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague.
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: V
authors.initials: V
authors.lastname: Zidek
authors.forename: M
authors.initials: M
authors.lastname: Simakova
authors.forename: V
authors.initials: V
authors.lastname: Kren
authors.forename: D
authors.initials: D
authors.lastname: Krenova
authors.forename: K
authors.initials: K
authors.lastname: Horky
authors.forename: M
authors.initials: M
authors.lastname: Jachymova
authors.forename: B
authors.initials: B
authors.lastname: Mikova
authors.forename: L
authors.initials: L
authors.lastname: Kazdova
authors.forename: T J
authors.initials: TJ
authors.lastname: Aitman
authors.forename: P C
authors.initials: PC
authors.lastname: Churchill
authors.forename: R C
authors.initials: RC
authors.lastname: Webb
authors.forename: N H
authors.initials: NH
authors.lastname: Hingarh
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: J M
authors.initials: JM
authors.lastname: Wang
authors.forename: E M
authors.initials: EM
authors.lastname: Lezin
authors.forename: T W
authors.initials: TW
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism; D018955:CD36 Antigens / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000235:genetics / Q000503:physiopathology; D016000:Cluster Analysis; D005838:Genotype; D006439:Hemodynamics / Q000235:genetics; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007328:Insulin / Q000097:blood / Q000235:genetics; D008055:Lipids / Q000097:blood / Q000235:genetics; D010641:Phenotype; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D012307:Risk Factors; D017384:Sequence Deletion
chemical_list: D001786:Blood Glucose; D018955:CD36 Antigens; D007328:Insulin; D008055:Lipids