title: Thymic carcinoma of the thymic hormone secretory type in a cow.
abstract: An 8-year-old Holstein cow had tumor nodules and enlarged lymph nodes in the mediastinum, and metastatic tumor masses in the pelvic cavity. The neoplastic cells were characterized by squamous features and intracytoplasmic vacuoles carrying microvilli, some of which contained periodic acid Schiff-positive globular cores, but tubular structures or goblet cells were absent. Many neoplastic cells stained positively for keratin, and occasional cells were positive for thymosin. The presence of secretory granules in the cytoplasm was confirmed by electron microscopy. This neoplasm was considered to be of thymic hormone-secreting epithelial cell origin.
authors.affiliation: Abashiri Livestock Hygiene Service Center, Kitami, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Oda
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D008198:Lymph Nodes / Q000473:pathology; D008479:Mediastinal Neoplasms / Q000473:pathology / Q000662:veterinary; D008871:Microvilli / Q000473:pathology; D010386:Pelvic Neoplasms / Q000473:pathology / Q000556:secondary; D013951:Thymus Hormones / Q000378:metabolism; D013953:Thymus Neoplasms / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D014617:Vacuoles / Q000473:pathology
chemical_list: D013951:Thymus Hormones