title: Glucose metabolism and the postprandial state.
abstract: Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of carbohydrates ingested and the way they are metabolized. In Type 2 diabetes, factors that contribute to excessive postprandial glucose excursions include disruption of insulin secretion, insufficient inhibition of hepatic glucose production and defective glucose storage in muscle. A number of measures may attenuate excessive postprandial blood glucose excursions. These include a diet high in 'low glycaemic index' foods and treatment with drugs that improve or restore the hormonal response (e.g. the sulphonylureas and the newer beta-cell mediated insulinotropic drugs such as repaglinide), that improve insulin sensitivity or that delay gastric emptying.
authors.affiliation: Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, University of Liège, Belgium.
authors.forename: P J
authors.initials: PJ
authors.lastname: Lefèbvre
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D019518:Postprandial Period / Q000502:physiology*
chemical_list: D005947:Glucose