Microbial metabolism of artemisitene.
Studies on the microbial transformation of the sesquiterpene endoperoxide artemisitene have revealed that artemisitene was metabolized by Aspergillus niger (NRRL 599) to yield 11-epi-artemisinin, 9 beta-hydroxydeoxy-11-epi-artemisinin and 9 beta-hydroxy-11-epi-artemisinnin. These metabolites were characterized on the basis of their spectral data.
Orabi
K Y
KY
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. kyorabi@ksu.edu.sa
Galal
A M
AM
Ibrahim
A R
AR
el-Feraly
F S
FS
Khalifa
S I
SI
el-Sohly
H N
HN
D037621:Artemisinins; D001234:Aspergillus niger / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000378:metabolism*
D037621:Artemisinins; D012717:Sesquiterpenes; C105118:artemisitene