Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (-), CD14 (-), and CD33(-).
Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (-), CD33(-), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).
García Vela
J A
JA
Department of Hematology, Hospital Universitario de Getafe, Madrid, Spain. javela@ran.es
Martin
M
M
Delgado
I
I
García Alonso
L
L
Monteserin
M C
MC
Benito
L
L
Somolinos
N
N
Oña
F
F
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D015703:Antigens, CD / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000145:classification; D018826:CD13 Antigens / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D009195:Peroxidase / Q000097:blood; D010641:Phenotype; D063268:Sialic Acid Binding Ig-like Lectin 3; D014178:Translocation, Genetic
D000903:Antibiotics, Antineoplastic; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000964:Antimetabolites, Antineoplastic; C571163:CD33 protein, human; D015815:Cell Adhesion Molecules; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D063268:Sialic Acid Binding Ig-like Lectin 3; D003561:Cytarabine; D009195:Peroxidase; D018826:CD13 Antigens; D015255:Idarubicin