title: Postoperative radiotherapy in the management of adult soft tissue sarcoma of the extremities: results with two different total dose, fractionation, and overall treatment time schedules.
abstract: OBJECTIVE
  This retrospective study was performed to evaluate two postoperative radiotherapy schedules in terms of dose, fractionation, and overall treatment time in soft tissue sarcoma (STS) of the extremities.
  
  
  METHODS
  Between January 1984 and December 1993, 62 patients with newly diagnosed localized STS of the extremities were treated with maximal conservative surgery and postoperative radiotherapy (RT). Forty-five patients received 50 Gy with conventional fractionation plus a boost dose (5 to 20 Gy). Seventeen patients had hyperfractionated accelerated radiotherapy (HFART) up to a dose of 45 Gy in 3 weeks.
  
  
  RESULTS
  With a median follow-up of 72 months, the 5-year local failure rate was 25%, the 5-year disease-free and overall survival rates were respectively 42% and 62%. The 3-year local relapse, disease-free, and overall survival rates were respectively 16%, 44%, and 70% in the conventional radiotherapy group, and 36%, 47%, and 82% in the HFART group (NS). No factor significantly influenced local control with a trend, however, in favor of conventional RT (p = 0.10).
  
  
  CONCLUSIONS
  HFART at the dose of 45 Gy does not seem to be superior to the standard RT schedule, neither in terms of local control, survival, nor in terms of long-term side effects. However this dose could be considered too low as well as the power of comparison between the two groups to draw definitive conclusions.
authors.affiliation: Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Péchoux
authors.forename: M C
authors.initials: MC
authors.lastname: Le Deley
authors.forename: S
authors.initials: S
authors.lastname: Delaloge
authors.forename: E
authors.initials: E
authors.lastname: Lartigau
authors.forename: C
authors.initials: C
authors.lastname: Levy-Piedbois
authors.forename: S
authors.initials: S
authors.lastname: Bonvalot
authors.forename: A
authors.initials: A
authors.lastname: Le Cesne
authors.forename: G
authors.initials: G
authors.lastname: Missenard
authors.forename: P
authors.initials: P
authors.lastname: Terrier
authors.forename: D
authors.initials: D
authors.lastname: Vanel
authors.forename: J
authors.initials: J
authors.lastname: Genin
authors.forename: F
authors.initials: F
authors.lastname: Fontaine
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000473:pathology; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D015996:Survival Rate