title: Transmyocardial laser revascularization: experimental studies in healthy porcine myocardium.
abstract: BACKGROUND
  Clinical studies have demonstrated a significant reduction of cardiac index shortly after transmyocardial laser revascularization in patients with low ejection fraction. We analyzed the influence of transmyocardial laser revascularization on healthy myocardium in pigs.
  
  
  METHODS
  Carbon dioxide channels were created in 20 pigs which were observed for 6 hours. Ten pigs received one laser channel and ten pigs two laser channels per cm2 in the left anterior descending artery region. Seven pigs served as controls. Perfusion (microspheres), function, histochemical, and histologic assessments were subsequently performed.
  
  
  RESULTS
  A significant deterioration of left ventricular stroke work index was observed shortly after transmyocardial laser revascularization in both laser groups (p < 0.05). After 6 hours the left ventricular stroke work index did not increase and showed significantly reduced values at rest (p < 0.05) and during stress in the laser groups (p < 0.01). Normal regional perfusion, small ischemic and necrotic areas, open laser channels in the left anterior descending artery region and significantly increased myocardial water content were observed in the laser groups (p < 0.01).
  
  
  CONCLUSIONS
  Carbon dioxide laser channels significantly decrease global heart function shortly after transmyocardial laser revascularization in healthy porcine myocardium. This myocardial tissue showed no recovery 6 hours postoperatively.
authors.affiliation: Division of Cardiovascular Surgery, Albert-Ludwigs-University School of Medicine, Freiburg, Germany. lutter@ch11.ukl.uni-freiburg.de
authors.forename: G
authors.initials: G
authors.lastname: Lutter
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yoshitake
authors.forename: J
authors.initials: J
authors.lastname: Schwarzkopf
authors.forename: E
authors.initials: E
authors.lastname: Nitzsche
authors.forename: F
authors.initials: F
authors.lastname: Beyersdorf
mesh_terms: D000818:Animals; D005069:Evaluation Studies as Topic; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D053685:Laser Therapy / Q000009:adverse effects; D009200:Myocardial Contraction; D009204:Myocardial Revascularization / Q000009:adverse effects / Q000379:methods*; D009206:Myocardium / Q000473:pathology*; D011897:Random Allocation; D012039:Regional Blood Flow; D013318:Stroke Volume; D013552:Swine; D016277:Ventricular Function, Left