title: Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A).
abstract: Most of disproportionate infants born small for gestational age (SGA) have an history of placental dysfunction with no explained cause. We report a case of an unexplained SGA infant with placental infarctions and thrombosis. Maternal thrombophilic disorder tests revealed that the patient was heterozygous for the A20210 prothrombin gene variant a newly identified thrombotic risk factor. It may be suggest that prothrombin gene variant, as factor V Leiden, could be a genetic risk factor for placental insufficiency.
authors.affiliation: Department of Obstetrics and Gynecology, Rouen University Hospital, France. eric.verspyck@chu-rouen.fr
authors.forename: E
authors.initials: E
authors.lastname: Verspyck
authors.forename: V
authors.initials: V
authors.lastname: Le Cam-Duchez
authors.forename: A
authors.initials: A
authors.lastname: Gravier
authors.forename: G
authors.initials: G
authors.lastname: Descargues
authors.forename: L
authors.initials: L
authors.lastname: Marpeau
authors.forename: J Y
authors.initials: JY
authors.lastname: Borg
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007238:Infarction; D010920:Placenta / Q000098:blood supply; D010927:Placental Insufficiency / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis
chemical_list: D011516:Prothrombin