title: [Etiology, pathogenesis and therapy of renal cell carcinoma].
abstract: Renal cell carcinoma (RCC) of the kidney accounts für 1-2% of all cancers and is the most common cancer arising in the adult kidney. The cause of RCC is not known. Several studies have shown a greater risk in smokers. Other factors are long-term dialysis and obesity, e.g. The morphological types of RCC have characteristic cytogenetic changes, but the details of genetic changes in renal tumorigenesis are not well understood. Approximately 13%-18% of patients with RCC have metastatic disease at initial presentation, and their prognosis remains unfavorable, because RCC is resistant to chemotherapy and radiotherapy. Only one-third of patients with RCC cured, and strenous efforts are being made to optimize immunotherapy in patients with advanced or metastatic disease.
authors.affiliation: Urologische Universitätsklinik, Giessen.
authors.forename: C G
authors.initials: CG
authors.lastname: Fischer
mesh_terms: D000276:Adjuvants, Immunologic; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D003582:Cytogenetics; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009392:Nephrectomy; D009857:Oncogenes
chemical_list: D000276:Adjuvants, Immunologic
vernacular_title: Atiologie, Pathogenese und Therapie des Nierenzellkarzinoms.