title: The "sins" of the fathers: self-healing squamous epithelioma in Scotland.
abstract: BACKGROUND
  A review is presented of the recent progress made in mapping of the hereditary skin disease "Ferguson-Smith multiple self-healing squamous epithelioma."
  
  
  METHODS
  The use of founder effects in an autosomal dominant disease is reviewed as applied to gene mapping efforts.
  
  
  RESULTS
  A common haplotype among Scottish families segregating Ferguson-Smith disease allowed the narrowing of the candidate gene interval and the identification of several possible disease-associated genes.
  
  
  CONCLUSIONS
  The gene for Ferguson-Smith multiple self-healing squamous epithelioma lies in a narrow region on chromosome 9q, along with several other important hereditary skin disease loci.
authors.affiliation: Genetic Studies Section/ LSB/ National Institute of Arthritis & Musculoskeletal & Skin Disease/ National Institutes of Health, Bethesda, Maryland 20892-2757, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Bale
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D018703:Founder Effect; D005799:Genes, Dominant / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D012606:Scotland; D012878:Skin Neoplasms / Q000235:genetics*; D014983:Xeroderma Pigmentosum / Q000235:genetics