Compartmental analysis revisited.
This paper gives a precise definition of compartment and shows that even when a compartmental model is not exactly identifiable, a range of its pharmacokinetic parameters can be determined. It is thus better to know approximate values of clearly defined parameters than exact values of quantities with no physical or physiological content.
Rescigno
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College of Pharmacy, University of Minnesota, Minneapolis, 55082, USA.
D008433:Mathematics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010599:Pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution