title: The biomechanics of leg ulceration.
abstract: Research performed in the late 1960s, using 24Na, suggested that the perfusion of skin and subcutaneous tissues is critically dependent on the relationship between capillary (Pc) and tissue pressures (Pt). Perfusion changes differed significantly between controls and patients with venous disease and the differences could be interpreted as evidence that Pt remained high in venous diseased patients. From this starting point, a biomechanical theory for the aetiology of venous ulceration was developed and tested by measuring skin elasticity, limb cross-sectional area and laser Doppler flux. The results confirm that, modelled as a two-compartment system (vascular and interstitial fluid), forces can be demonstrated sufficient to cause intermittent capillary closure and subsequent reperfusion injury. These forces are maximal in the gaiter area, the site of most leg ulcers.
authors.affiliation: Department of Vascular Surgery, Southampton University Hospitals.
authors.forename: A
authors.initials: A
authors.lastname: Chant
mesh_terms: D002196:Capillaries / Q000503:physiopathology; D004548:Elasticity; D006801:Humans; D017078:Laser-Doppler Flowmetry; D007871:Leg Ulcer / Q000209:etiology* / Q000503:physiopathology; D008954:Models, Biological; D011187:Posture; D015427:Reperfusion Injury / Q000150:complications* / Q000503:physiopathology; D012867:Skin / Q000098:blood supply* / Q000503:physiopathology; D013314:Stress, Mechanical; D014648:Varicose Veins / Q000150:complications / Q000503:physiopathology