title: Voltage-gated sodium channel genes hscp and hDSC1 of Heliothis virescens F. genomic organization.
abstract: We report the genomic sequence of hscp, a sodium channel alpha subunit gene for Heliothis virescens. A 32-kb genomic clone and six independent RT-PCR products covering almost the entire coding region of the gene, contained thirty-one deduced exons with a translation of 1695 residues. Overall amino acid similarity to the para locus of Drosophila melanogaster was 86%. The transcription of the gene was complex. Alternate splicing was evident for five optional exons and a pair of mutually exclusive exons. A number of alternatively spliced mRNA revealed a deduced translation product that included only the first homology domain. We also report the first partial sequence for hDSC1, a presumed orthologous of the DSC1 sodium channel alpha subunit gene of D. melanogaster.
authors.affiliation: Department of Entomology, University of Arizona, Tucson 85721, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Park
authors.forename: M F
authors.initials: MF
authors.lastname: Taylor
authors.forename: R
authors.initials: R
authors.lastname: Feyereisen
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D017344:Genes, Insect; D006801:Humans; D019476:Insect Proteins / Q000235:genetics*; D015640:Ion Channel Gating; D008969:Molecular Sequence Data; D009036:Moths / Q000235:genetics*; D012333:RNA, Messenger; D017386:Sequence Homology, Amino Acid; D015222:Sodium Channels / Q000235:genetics*
chemical_list: D018076:DNA, Complementary; C120724:DSC1 protein, Heliothis virescens; D019476:Insect Proteins; D012333:RNA, Messenger; D015222:Sodium Channels