Comparison of serum fructosamine and blood glycosylated hemoglobin concentrations for assessment of glycemic control in cats with diabetes mellitus.
OBJECTIVE
To correlate serum fructosamine concentrations with established measures of glycemic control and to compare serum fructosamine and blood glycosylated hemoglobin (GHb) concentrations as a means for assessing glycemic control in diabetic cats.


METHODS
Longitudinal cohort study.


METHODS
26 healthy cats, 5 cats with stress-induced hyperglycemia, 15 untreated diabetic cats, and 36 treated diabetic cats.


METHODS
Control of glycemia was classified and monitored and serum fructosamine and blood GHb concentrations were measured for 12 poorly controlled diabetic cats before and after improving glycemic control, 8 well-controlled treated diabetic cats before and after glycemic control deteriorated, and 5 cats with diabetes mellitus before and after onset of stress-induced hyperglycemia.


RESULTS
Mean serum fructosamine and blood GHb concentrations were significantly higher in untreated diabetic cats, compared with healthy cats, and in 24 poorly controlled diabetic cats, compared with 12 well-controlled diabetic cats. Mean serum fructosamine and blood GHb concentrations decreased significantly in 12 poorly controlled diabetic cats after improving glycemic control and increased significantly in 8 well-controlled diabetic cats after glycemic control deteriorated. A significant stress-induced increase in mean blood glucose concentration was evident 12 hours after insulin administration, but not in 5 docile diabetic cats that became fractious.


CONCLUSIONS
Serum fructosamine and blood GHb concentrations are clinically useful tools for monitoring control of glycemia in cats with diabetes mellitus.
Elliott
D A
DA
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Nelson
R W
RW
Reusch
C E
CE
Feldman
E C
EC
Neal
L A
LA
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002371:Cat Diseases / Q000097:blood* / Q000188:drug therapy / Q000517:prevention & control; D002415:Cats; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D019270:Fructosamine / Q000097:blood*; D005913:Glipizide / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000032:analysis*; D006943:Hyperglycemia / Q000097:blood / Q000517:prevention & control / Q000662:veterinary*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008137:Longitudinal Studies; D012016:Reference Values
D001786:Blood Glucose; D019270:Fructosamine; D005913:Glipizide; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin