In vitro susceptibilities of Chlamydia pneumoniae isolates from German patients and synergistic activity of antibiotic combinations.
The susceptibilities of six Chlamydia pneumoniae type strains and of six German patient isolates to erythromycin, azithromycin, roxithromycin, clarithromycin, doxycycline, ofloxacin, and rifampin were investigated. MICs and minimal chlamydicidal concentrations were all within the ranges reported previously. Combinations of azithromycin with either ofloxacin, doxycycline, or rifampin, as well as combinations of three antibiotics (rifampin, azithromycin, and ofloxacin or doxycycline), showed synergistic activity against C. pneumoniae.
Freidank
H M
HM
Department of Bacteriology, Institute for Medical Microbiology and Hygiene, University of Freiburg, D-79104 Freiburg, Germany. friedank@sun11.ukl.uni-freiburg.de
Losch
P
P
Vögele
H
H
Wiedmann-Al-Ahmad
M
M
D000900:Anti-Bacterial Agents; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents