Nonpharmacologic treatment of hypertriglyceridemia: focus on fish oils.
Early studies in Greenland Eskimos stimulated interest in evaluating the effect of Omega-3 fatty acids on coronary artery disease. Subsequent studies showed a significant decrease in triglyceride levels in patients receiving high doses of fish oil containing DHA and EPA. Slight increases in LDL were also observed in patients receiving fish oil supplements. These studies have also shown a dose-response effect which persists as long as supplementation continues. Later trials, specifically the Diet and Reinfarction Trial and the Indian Experiment of Infarct Survival, have demonstrated a reduction in cardiac death rates and in the incidence of cardiac symptoms in patients receiving fish oil.
Harris
W S
WS
Department of Cardiovascular Research, Saint Luke's Hospital, Kansas City, Missouri 64111, USA.
D018849:Controlled Clinical Trials as Topic; D003327:Coronary Disease / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D015228:Hypertriglyceridemia / Q000178:diet therapy* / Q000401:mortality / Q000503:physiopathology; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D015996:Survival Rate; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism
D005395:Fish Oils; D008077:Lipoproteins, LDL; D014280:Triglycerides