Detection of HGV in serum and peripheral blood mononuclear cells of maintenance haemodialysis patients.
The aim of the present study was to investigate the prevalence of hepatitis G virus (HGV) and also hepatitis C virus (HCV) infections in maintenance haemodialysis patients, and to identify extrahepatic sites as HGV reservoirs. HGV RNA was detected in the serum of 6/61 (10%) patients and in the peripheral blood mononuclear cells of 2/61 (3%) patients (one of whom was serum negative). These findings suggest that lymphoid cells constitute an extrahepatic HGV reservoir. HCV RNA was detected in 7/61 (11%) patients. Five of these patients (71%) were identified as carrying HCV genotype 1b. Co-infection with HCV and HGV was detected only in one patient. Haemodialysis patients are at risk for HGV infection, by nosocomial routes or via transfusions. HGV itself does not seem to be an important cause of hepatitis since all six HGV RNA positive patients not co-infected by HCV or HBV showed normal ALT values.
Basaras
M
M
Department of Microbiology, School of Medicine, University of Basque Country, Bilbao, Spain. oipbaibm@lg.ehu.es
Arrese
E
E
Cabrera
F
F
Ezpeleta
C
C
Cisterna
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D018067:Flaviviridae / Q000235:genetics / Q000302:isolation & purification; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007963:Leukocytes, Mononuclear; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D006435:Renal Dialysis / Q000009:adverse effects*; D013030:Spain / Q000453:epidemiology; D015163:Superinfection / Q000453:epidemiology
D012367:RNA, Viral