title: Evaluation of antiallergic activity (type I hypersensitivity) of Inula racemosa in rats.
abstract: Alcoholic extract of root of Inula racemosa, was studied for its antiallergic effect in experimental models of type I hypersensitivity, viz. egg albumin induced passive cutaneous anaphylaxis (PCA) and mast cell degranulation in albino rats. The alcoholic extract was prepared by the process of continuous heat extraction. LD50 of this extract was found to be 2100 +/- 60 mg/kg, i.p. Assessment of protection against egg albumin induced passive cutaneous anaphylaxix by different doses of Inula racemosa was done by giving drug intraperitoneally or orally for seven days or once only. Mast cell degranulation studies were done by using compound 48/80 as degranulation agent with same dosage schedule. Inula racemosa (i.p. as well as p.o.) showed significant protection against egg albumin induced PCA. Protection against compound 48/80 induced mast cell degranulation by alcoholic extract of Inula racemosa (single dose) was similar to that of disodium cromoglycate. The seven days drug treatment schedule showed greater protection than disodium cromoglycate intraperitoneally. The results suggest that Inula racemosa possesses potent antiallergic properties in rats.
authors.affiliation: Department of Pharmacology and Therapeutics, K.G.'s Medical College, Lucknow.
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: P P
authors.initials: PP
authors.lastname: Gupta
authors.forename: R
authors.initials: R
authors.lastname: Prasad
authors.forename: K S
authors.initials: KS
authors.lastname: Dixit
authors.forename: G
authors.initials: G
authors.lastname: Palit
authors.forename: B
authors.initials: B
authors.lastname: Ali
authors.forename: G
authors.initials: G
authors.lastname: Misra
authors.forename: R C
authors.initials: RC
authors.lastname: Saxena
mesh_terms: D000818:Animals; D005260:Female; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000517:prevention & control*; D038143:Inula; D007444:Inulin / Q000627:therapeutic use*; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008515:Medicine, Ayurvedic; D010323:Passive Cutaneous Anaphylaxis; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D003189:p-Methoxy-N-methylphenethylamine; D007444:Inulin