Geraniol is a potent inducer of apoptosis-like cell death in the cultured shoot primordia of Matricaria chamomilla.
We screened various isoprenoids to search for inducers of apoptosis-like cell death ("apoptosis") in the shoot primordia of Matricaria chamomilla and found that geraniol has the most potent apoptosis-inducing activity among terpenoids, as judged from DNA fragmentation in the cells. The apoptosis-inducing activity of geraniol is concentration and time dependent. Morphologically, the nuclei of the cells treated with 5 mM geraniol were condensed and fragmented.
Izumi
S
S
Graduate School of Science, Hiroshima University, Higashi-Hiroshima, 739-8526, Japan.
Takashima
O
O
Hirata
T
T
D000080462:Acyclic Monoterpenes; D017209:Apoptosis; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D018521:Plant Physiological Phenomena; D010940:Plant Proteins / Q000502:physiology*; D013729:Terpenes / Q000494:pharmacology*; D013997:Time Factors
D000080462:Acyclic Monoterpenes; D010940:Plant Proteins; D013729:Terpenes; C007836:geraniol