title: CD5 expression in human B-cell populations.
abstract: The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells. Here, Pierre Youinou, Christophe Jamin and Peter Lydyard review current knowledge of B-1 and B-2 cells, and propose that CD5 has different functions when expressed by different B-cell subpopulations.
authors.affiliation: Laboratory of Immunology, Institut de Synergie des Sciences et de la Santé, Brest University Medical School Hospital, BP 824, F-29609 Brest Cedex, France. youinou@univ-brest.fr
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: C
authors.initials: C
authors.lastname: Jamin
authors.forename: P M
authors.initials: PM
authors.lastname: Lydyard
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D017209:Apoptosis; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D018956:CD5 Antigens / Q000378:metabolism*; D002455:Cell Division; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D018956:CD5 Antigens; C064228:CD72 protein, human; D008024:Ligands