Heparinoids: structure, biological activities and therapeutic applications.
Heparin is an important polyanionic drug having a wide variety of different biological activities. Substantial research effort has focused on the preparation of improved heparins and heparin analogues that might exhibit higher specificity and decreased side effects. These heparin analogues or heparinoids include sulfated polysaccharides from plant and animal origin, synthetic derivatives of polysaccharides, and acidic oligosaccharides and their small synthetic analogues. The structure, biological activities and therapeutic potential of these heparinoids are discussed.
Gunay
N S
NS
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa City, USA.
Linhardt
R J
RJ
D002236:Carbohydrate Conformation; D006496:Heparinoids / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D006496:Heparinoids