HIV: a new role for Nef in the spread of HIV.
The HIV Nef protein downregulates the cell-surface expression of the HIV receptor glycoprotein CD4, but the significance of this event has remained obscure. Recent data suggest that Nef reduces cell-surface CD4 to promote the efficient spread of the virus.
Harris
M
M
Division of Microbiology, School of Biochemistry and Molecular Biology,University of Leeds, Leeds LS2 9JT, UK. mharris@bmb.leeds.ac.uk
D015704:CD4 Antigens / Q000378:metabolism; D015536:Down-Regulation; D015693:Gene Products, nef / Q000502:physiology*; D006678:HIV / Q000472:pathogenicity* / Q000502:physiology*; D015658:HIV Infections / Q000821:virology; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D014779:Virus Replication; D054311:nef Gene Products, Human Immunodeficiency Virus
D015704:CD4 Antigens; D015693:Gene Products, nef; D054311:nef Gene Products, Human Immunodeficiency Virus