Synthesis and biological evaluation of alpha-mannosidase inhibitory activity of three deoxy derivatives of mannostatin A.
Three deoxy derivatives of alpha-mannosidase inhibitor mannostatin A have been synthesized and their inhibitors activity for Jack beans alpha-mannosidase evaluated in order to elucidate roles of each hydroxyl groups of the inhibitor The 1- and 2-deoxy derivatives have preserved inhibitory potentials although they lowered the activity one-hundred fold compared to the parent, but the 3-deoxy derivative lost activity.
Ogawa
S
S
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Morikawa
T
T
D003517:Cyclopentanes / Q000138:chemical synthesis*; D007887:Fabaceae / Q000201:enzymology; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008361:Mannosidases / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D010946:Plants, Medicinal; D043323:alpha-Mannosidase
C121219:1-deoxymannostatin A; C121220:2-deoxymannostatin A; C121221:3-deoxymannostatin A; D003517:Cyclopentanes; C060107:mannostatin A; D008361:Mannosidases; D043323:alpha-Mannosidase