[Perioperative plasma amino acid spectrum analysis in portal hypertensive cirrhotic patients undergoing portacaval H-graft shunt].
Perioperative plasma amino acid spectrum (PAAS) was analysed in 10 portal hypertensive patients (PH) receiving portacaval H-graft shunt (D = 8 mm) and 10 gastroenteropathic patients (GE) without hepatic disease. In both groups, arterial, peripheral and hepatic venous blood was drawn for analysis immediately pre- and post-operation on the table, postoperative day 1 and 3, respectively. It was found that amino acid concentration decreased in both groups but in PH group it was changed significantly. The preoperative branched chain amino acid (BCAA)/aromatic amino acid (AAA) ratio was less than 2 in the PH group and larger than 3 in the GE group after operation. The ratio did not change significantly in both groups after operation. In the PH group, the pre- and post-operative BCAA and AAA level in hepatic vein was higher than in other sites. The immediately BCAA and AAA levels were lower than preoperative levels. Among the changes the postoperative decrease of VAL and LEU was significant. Both BCAA and AAA reached preoperative level at postoperative day3. The results reveal that small diameter portacaval shunt has no significant influence on PAAS. The temporary decrease of amino acid levels postoperatively may be related to the stress of operation and liver impairement.
Zhu
J
J
Department of Surgery, People's Hospital, Beijing Medical University.
Liu
F
F
Leng
X
X
D000328:Adult; D000597:Amino Acids, Branched-Chain / Q000097:blood; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood* / Q000601:surgery; D007432:Intraoperative Period; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000097:blood; D011170:Portasystemic Shunt, Surgical; D014443:Tyrosine / Q000097:blood
D000597:Amino Acids, Branched-Chain; D014443:Tyrosine; D010649:Phenylalanine