title: Rational use of chemotherapy. It is not just rat poison.
abstract: The role of chemotherapy in the management of advanced prostate cancer is expanding. Multiple regimens that use a variety of drugs have been developed. A chemotherapy regimen may appear to be a collection of randomly chosen agents. This article presents the theoretic foundation for the development of combination chemotherapy.
authors.affiliation: Department of Internal Medicine, University of Michigan Cancer Center, Ann Arbor, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Kamradt
authors.forename: E A
authors.initials: EA
authors.lastname: Klein
authors.forename: K J
authors.initials: KJ
authors.lastname: Pienta
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D051381:Rats
chemical_list: D000970:Antineoplastic Agents