title: Synthesis and analgesic activity of some triazoles and triazolothiadiazines.
abstract: The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described. The chemical structure of the compounds were elucidated by analytical, IR, 1H NMR and mass spectral studies. Some of the newly synthesized compounds were tested for analgesic activity and compounds 5b, 5c, and 5d exhibited promising analgesic activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Turan-Zitouni
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kaplancikli
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: F S
authors.initials: FS
authors.lastname: Kiliç
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C120387:6-(2-hydroxy-4-methoxyphenyl)-3-((5,6,7,8-tetrahydronaphthalen-2-yl)oxymethyl)-7H-1,2,4-triazolo(3,4-b)-1,3,4-thiadiazine; C120386:6-(4-chlorophenyl)-3-((5,6,7,8-tetrahydronaphthalen-2-yl)oxymethyl)-7H-1,2,4-triazolo(3,4-b)-1,3,4-thiadiazine; C120385:6-(4-nitrophenyl)-3-((5,6,7,8-tetrahydronaphthalen-2-yl)oxymethyl)-7H-1,2,4-triazolo(3,4-b)-1,3,4-thiadiazine; D018712:Analgesics, Non-Narcotic; D013829:Thiadiazines; D014230:Triazoles