title: Concomitant splenectomy for hypersplenic thrombocytopenia in hepatic resection for hepatocellular carcinoma.
abstract: OBJECTIVE
  Resection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis and hypersplenic thrombocytopenia (HSTC) is risky. Controversy exists concerning the role of concomitant splenectomy for HSTC in cirrhotic patients undergoing hepatectomy for HCC.
  
  
  METHODS
  During the past 10 years, 294 patients have undergone hepatic resection for HCC in our department. Among them, 11 cirrhotic patients with severe HSTC (platelet count < or = 80000/mm3) underwent splenectomy simultaneously. The clinical outcomes were retrospectively reviewed.
  
  
  RESULTS
  The resected spleen weighed 479 +/- 242 g. The post-operative mortality and morbidity were 9.1% and 27.3%, respectively. In all patients, the platelet count was elevated to above 100000/mm3, and serum total bilirubin was significantly lowered within 1 week of operation. The overall 5-year actuarial and disease-free survival rates were 66.7%. None of the patients developed severe infectious complications during the follow-up period.
  
  
  CONCLUSIONS
  Concomitant splenectomy for severe HSTC in cirrhotic patients undergoing hepatectomy for HCC is justified as the benefits of concomitant splenectomy by far surpass the adverse effects.
authors.affiliation: Department of Surgery, Taichung Veterans General Hospital, Taiwan.
authors.forename: M C
authors.initials: MC
authors.lastname: Lin
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: W L
authors.initials: WL
authors.lastname: Ho
authors.forename: D C
authors.initials: DC
authors.lastname: Yeh
authors.forename: T J
authors.initials: TJ
authors.lastname: Liu
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy; D006801:Humans; D006971:Hypersplenism / Q000401:mortality / Q000601:surgery*; D008103:Liver Cirrhosis / Q000401:mortality / Q000601:surgery; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D013156:Splenectomy; D013624:Taiwan; D013921:Thrombocytopenia / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome