title: Clinical investigation of bronchioloalveolar carcinoma: a retrospective analysis of 53 patients in a single institution.
abstract: BACKGROUND
  Bronchioloalveolar carcinoma (BAC) has been reported to have unique clinicopathological features.
  
  
  METHODS
  This retrospective study was performed using data base including 871 patients treated for primary lung cancer between 1981 and 1995.
  
  
  RESULTS
  The patients with BAC included a larger proportion of female (P = 0.029) and smoked less (P = 0.002) than those with non-BAC. There was no difference in survival between surgically resected patients with BAC and those with non-BAC. Clinical Stage IV patients with BAC had a better response to chemotherapy than did those with non-BAC. Survival in the former group was better than that in the latter on univariate analysis, but the significance of this difference was not confirmed multivariate analysis.
  
  
  CONCLUSIONS
  The patients with BAC included a larger proportion of females and smoked less than those with non-BAC. Treatment results for BAC was comparable to those for non-BAC.
authors.affiliation: Department of Internal Medicine, National Shikoku Cancer Center Hospital, Matsuyama, Japan. nfuji@qc4.so-net.ne.jp
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Segawa
authors.forename: N
authors.initials: N
authors.lastname: Takigawa
authors.forename: K
authors.initials: K
authors.lastname: Hotta
authors.forename: D
authors.initials: D
authors.lastname: Kishino
authors.forename: M
authors.initials: M
authors.lastname: Shimono
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: H
authors.initials: H
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Mandai
authors.forename: K
authors.initials: K
authors.lastname: Eguch
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000097:blood / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000097:blood; D018287:Carcinoma, Large Cell / Q000097:blood / Q000473:pathology* / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D002272:Carcinoembryonic Antigen