[Efficacy of meropenem in the treatment of severe complicated urinary tract infections].
The clinical and bacteriological efficacies of meropenem in the treatment of 12 patients with urinary tract infection were studied. In 8 patients the drug was administered intravenously in a dose of 1 g every 8 hours and in 4 patients with the creatinine clearance below 50 ml/min it was administered in a dose of 1 g every 12 hours (the treatment course of 7 to 10 days). Meropenem was used in the monotherapy. Severe complicated urinary tract infections were mainly observed in the patients with long-term urolithiasis, subjected to repeated surgical interventions and isolating as a rule polyresistant strains of Pseudomonas aeruginosa and E.agglomerans as the pyelonephritis pathogens at a titre of 5 x 10(5)-5 x 10(8) microbial cells per 1 ml of the urine susceptible to meropenem in 80 to 96 per cent of the cases. The clinical efficacy of the drug was stated in all the patients while the bacteriological efficacy amounted to 88.9 per cent.
Lopatkin
N A
NA
Research Institute of Urology, Ministry of Public Health of the Russian Federation, Moscow.
Derevianko
I I
II
Khodyreva
L A
LA
Kotliarova
G A
GA
Kondrat'eva
E M
EM
Lavrinova
L N
LN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D013845:Thienamycins / Q000627:therapeutic use*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D013845:Thienamycins; D000077731:Meropenem
Effektivnost' meropenema pri lechenii tiazhelykh oslozhnennykh infektsiĭ mochevyvodiashchikh puteĭ.