title: Cranial edema associated with a protein-losing nephropathy in a golden-mantled flying fox (Pteropus pumilus).
abstract: An adult golden-mantled flying fox (Pteropus pumilus) was diagnosed with nephrotic syndrome on the basis of the findings of proteinuria, hypoalbuminemia, hypercholesterolemia, and cranial edema. Membranoproliferative glomerulitis and interstitial nephritis were confirmed antemortem by renal biopsy. The bat had received seven injections of oxytocin in the period immediately prior to presentation. The possible role of oxytocin in the development of the nephropathy is discussed. Supportive care and treatment with a single plasma transfusion, furosemide, and prednisone led to a gradual but complete resolution of the nephrotic syndrome in this animal.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Deem
authors.forename: D J
authors.initials: DJ
authors.lastname: Heard
authors.forename: T L
authors.initials: TL
authors.lastname: Clippinger
authors.forename: C D
authors.initials: CD
authors.lastname: Buergelt
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D001803:Blood Transfusion / Q000662:veterinary; D002685:Chiroptera; D003937:Diagnosis, Differential; D004232:Diuretics / Q000627:therapeutic use; D004487:Edema / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006403:Hematologic Tests / Q000662:veterinary; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D009404:Nephrotic Syndrome / Q000150:complications / Q000628:therapy / Q000662:veterinary*; D010121:Oxytocin / Q000009:adverse effects; D011241:Prednisone / Q000627:therapeutic use; D012886:Skull
chemical_list: D004232:Diuretics; D005938:Glucocorticoids; D010121:Oxytocin; D005665:Furosemide; D011241:Prednisone