Possible interaction between new quinolones and immune functions in macrophages.
Some of the immunological effects of a variety of new quinolones on chemotaxis and the production of superoxide anion in rat macrophages were studied. All of the new quinolones examined at a dose range of 0.5 to 50 microg/ml significantly inhibited chemotaxis in a dose-dependent manner in rat macrophages. Moreover, the new quinolones at a dose of 0.5 microg/ml were effective in markedly potentiating the generation of superoxide anion. These results indicate that the new quinolones may modulate immune functions in rat macrophages.
Azuma
Y
Y
Department of Pharmacology, Osaka Dental University, Hirakata, Japan. aazuma@cc.osaka-dent.ac.jp
Shinohara
M
M
Murakawa
N
N
Endo
M
M
Ohura
K
K
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D015363:Quinolones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D015363:Quinolones; D017382:Reactive Oxygen Species; D013481:Superoxides