Antibody forming cell response to nickel and nickel-coated fly ash in rats.
The potential of nickel as nickel chloride, native fly ash and Ni-coated fly ash to alter pulmonary and systemic immune response was evaluated upon intratracheal (I/T) exposure of rats. The animals were sensitised with sheep red blood cells (SRBC) through I/T and intraperitoneal (I/P) routes. Nickel exposure resulted in a decrease in the number of antibody forming cells (AFC) in lung associated lymph nodes (LALN) and spleen. In rats exposed to native fly ash there was a reduction in the number of AFC in LALN but not in spleen. The results did not demonstrate any significant difference in the immunosuppression of fly ash and Ni-coated fly ash exposed rats. The decrease in AFC formation in Ni-coated fly ash exposed animals was of a lesser magnitude than in rats exposed to Ni-alone.
Dogra
S
S
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Khanna
A K
AK
Kaw
J L
JL
D000280:Administration, Inhalation; D000818:Animals; D000917:Antibody Formation; D002244:Carbon / Q000276:immunology* / Q000633:toxicity; D060729:Coal Ash; D005260:Female; D007109:Immunity / Q000187:drug effects; D007165:Immunosuppression Therapy; D008168:Lung / Q000187:drug effects* / Q000276:immunology; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D009532:Nickel / Q000276:immunology* / Q000633:toxicity; D052638:Particulate Matter; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D060729:Coal Ash; D052638:Particulate Matter; D002244:Carbon; D009532:Nickel