The concentrations of clinafloxacin in alveolar macrophages, epithelial lining fluid, bronchial mucosa and serum after administration of single 200 mg oral doses to patients undergoing fibre-optic bronchoscopy.
The concentrations of clinafloxacin were measured in serum, bronchial mucosa, alveolar macrophages and epithelial lining fluid after single 200 mg oral doses of clinafloxacin had been administered to 15 subjects who were undergoing bronchoscopy. Concentrations were measured using a microbiological assay method. Mean concentrations in serum, bronchial mucosa, alveolar macrophages and epithelial lining fluid at a mean of 1.27 h post-dose were 1.54, 2.65, 15.60 and 2.71 mg/L respectively. These site concentrations exceeded the MIC90 for common respiratory pathogens and indicate that clinafloxacin is likely to be effective in the treatment of a wide range of respiratory tract infections.
Honeybourne
D
D
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham, UK.
Andrews
J M
JM
Cunningham
B
B
Jevons
G
G
Wise
R
R
D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000032:analysis*; D019072:Antibiotic Prophylaxis; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D001999:Bronchoscopy / Q000379:methods; D004305:Dose-Response Relationship, Drug; D005260:Female; D005336:Fiber Optic Technology; D024841:Fluoroquinolones; D006801:Humans; D016676:Macrophages, Alveolar / Q000737:chemistry*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C057477:clinafloxacin