Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.
1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
Rotzinger
S
S
Department of Psychiatry, University of Alberta, Edmonton, Canada.
Bourin
M
M
Akimoto
Y
Y
Coutts
R T
RT
Baker
G B
GB
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism* / Q000493:pharmacokinetics; D018687:Antidepressive Agents, Second-Generation / Q000378:metabolism* / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D004347:Drug Interactions / Q000502:physiology; D006801:Humans
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation