title: [Membrane stabilizers (chromones and ketotifen)].
abstract: The drugs called "Membrane stabilisers" are composed of cromones (sodium cromoglycate and nedocromil) and Ketotifen. They inhibit the degranulation of mastocytes by a membrane stabilising effect. Ketotifen is distinguished from the cromones by a conjoint antihistamine effect. Nowadays, the indications are for prophylactic treatment of allergic asthma, rhinitis and allergic conjunctivitis and the manifestations of food allergy. Therapeutic efficacy seems to be good in intermittent or mildly persistent asthma, especially in children or young subjects. Secondary effects are rare and generally benign, with reduced contra-indications.
authors.affiliation: Laboratoire d'Immuno-Allergologie, CHU, Angers.
authors.forename: E
authors.initials: E
authors.lastname: Mancel
authors.forename: M
authors.initials: M
authors.lastname: Drouet
authors.forename: A
authors.initials: A
authors.lastname: Sabbah
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy; D002462:Cell Membrane / Q000187:drug effects*; D003231:Conjunctivitis / Q000188:drug therapy; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008407:Mast Cells / Q000187:drug effects; D017835:Nedocromil / Q000627:therapeutic use*; D012220:Rhinitis / Q000188:drug therapy
chemical_list: D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D017835:Nedocromil; D004205:Cromolyn Sodium; D007665:Ketotifen
vernacular_title: Les stabilisateurs de membrane (cromones et kétotifène).