A genetic mutation in PPAR gamma is associated with enhanced fat cell differentiation: implications for human obesity.
Human obesity may have genetic causes, but determining the specific genes involved has been difficult. The peroxisome proliferator-activated receptor gamma (PPAR gamma) gene encodes a protein that plays an important role in the differentiation of fat cells. A mutation has been discovered in this gene which leads to a receptor that cannot be inactivated. This mutation, while probably rare, is associated with extreme obesity.
Freake
H C
HC
Department of Nutritional Sciences, University of Connecticut, Storrs 06269-4017, USA.
D017667:Adipocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009154:Mutation; D009765:Obesity / Q000235:genetics*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors