Improved suppression by dietary taurine of the fecal excretion of bile acids from hypothyroid rats.
The effect of dietary taurine, 2-aminoethanesulfonic acid, on hypercholesterolemia caused by thiouracil-induced hypothyroidism was investigated in hypothyroid rats. Serum total- and HDL-cholesterol were significantly increased, and the excretion of fecal bile acids was significantly decreased. Taurine did not change the hypercholesterolemia, but significantly recovered the excretion of bile acids.
Mochizuki
H
H
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Takido
J
J
Yokogoshi
H
H
D000818:Animals; D013956:Antithyroid Agents; D001647:Bile Acids and Salts / Q000378:metabolism*; D004032:Diet; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry*; D006937:Hypercholesterolemia / Q000209:etiology / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D013956:Antithyroid Agents; D001647:Bile Acids and Salts; D013963:Thyroid Hormones; D013654:Taurine; D011441:Propylthiouracil