title: Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis.
abstract: OBJECTIVE
  To distinguish between benign and malignant tumors in the peripheral nerves.
  
  
  METHODS
  The clinical, imaging and histologic findings of 99 benign and 16 malignant tumors in the peripheral nerves were reviewed retrospectively.
  
  
  RESULTS
  Preoperative motor weakness was observed in only six of 99 benign tumors and was mild, while slight to severe motor weakness was present in 15 of 16 malignant lesions. Pain at rest was present in five of 99 benign tumors and in 15 of 16 malignant tumors. All benign lesions showed a smooth tumoral margin, while half the malignant lesions showed an invasive margin on CT or MRI. Thirteen of 28 benign lesions on CT and nine of 23 on MRI showed round to geographic central enhancement, but this pattern was not seen in malignant lesions.
  
  
  CONCLUSIONS
  Absence of severe motor weakness and a central enhancement pattern strongly suggest a benign nature, while severe rest pain and invasive tumor margin suggest malignant lesions in peripheral nerve tumors.
authors.affiliation: Department of Orthopaedic Surgery, Niigata Cancer Center Hospital, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ogose
authors.forename: T
authors.initials: T
authors.lastname: Hotta
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: S
authors.initials: S
authors.lastname: Yamamura
authors.forename: N
authors.initials: N
authors.lastname: Hosaka
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D009442:Neurilemmoma / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D009455:Neurofibroma / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D010146:Pain; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed