title: [A case of juvenile Parkinson disease with vocal cord abductor paralysis in the course of malignant syndrome].
abstract: We report a 60-year-old woman with juvenile Parkinson disease (PD) with vocal cord abductor paralysis (VCAP). She had suffered from juvenile PD for 30 years. She was admitted in February 1998 to our clinical unit, because of malignant syndrome induced by dehydration. Neurological examination revealed disturbance of consciousness, hand tremor, dyskinesia of the trunk and all extremities, and rigidity. Laboratory examinations disclosed leukocytosis, renal dysfunction, hypermyoglobinemia, and elevation of the serum creatine kinase. Six days after admission, dyspnea and inspiratory stridor were noted, and the respiratory distress worsened. Endoscopy of the upper airways revealed that the vocal cord was in the midline or paramedian position. There are some cases of PD with VCAP, but such a case is very rare in Japan. We discussed the pathogenic mechanisms of these conditions, and speculated that VCAP was associated with malignant syndrome in our case.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Nakane
authors.forename: M
authors.initials: M
authors.lastname: Motomura
authors.forename: T
authors.initials: T
authors.lastname: Furuya
authors.forename: S
authors.initials: S
authors.lastname: Shirabe
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D005260:Female; D006801:Humans; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000150:complications*; D010300:Parkinson Disease / Q000150:complications*; D014826:Vocal Cord Paralysis / Q000209:etiology*