title: Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR.
abstract: The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.
authors.affiliation: Medical Faculty, University of Milan, 20133 Milano, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Corrado
authors.forename: P
authors.initials: P
authors.lastname: Colapietro
authors.forename: L
authors.initials: L
authors.lastname: Larizza
authors.forename: P
authors.initials: P
authors.lastname: Riva
mesh_terms: D018244:Chromosomes, Artificial, Yeast; D002886:Chromosomes, Human, Pair 17; D020451:Contig Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D051858:Forkhead Transcription Factors; D006801:Humans; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D014157:Transcription Factors; C090140:Whn protein