title: Effect of nasogastric tube size on gastroesophageal reflux and microaspiration in intubated patients.
abstract: BACKGROUND
  Little evidence exists to support the theory that small-bore nasogastric tubes prevent gastroesophageal reflux and microaspiration in intubated patients.
  
  
  OBJECTIVE
  To determine whether gastroesophageal reflux and microaspiration in intubated patients can be reduced by the use of a small-bore nasogastric tube.
  
  
  METHODS
  Randomized, two-period crossover trial.
  
  
  METHODS
  Respiratory intensive care unit of a university hospital.
  
  
  METHODS
  17 patients intubated for more than 72 hours.
  
  
  METHODS
  Radioactive technetium colloid was instilled in each patient's stomach. Patients were studied with two nasogastric tubes (one tube with a 6.0-mm external bore and one tube with a 2.85-mm external bore) in randomized order; measurements of radioactive counts with the alternate size of nasogastric tube were repeated 72 hours after original measurements were taken. Sequential samples of serum, gastric juice, and pharyngeal and tracheal secretions were obtained.
  
  
  METHODS
  Comparison of the time course of radioactive counting in all samples (obtained during the use of each nasogastric tube size in each patient).
  
  
  RESULTS
  The mean radioactive count of pharyngeal aspirates (P = 0.004) was greater than the baseline count at all time points, as was the cumulative radioactive count of pharyngeal aspirates 17 hours after the first dose of technetium colloid was administered (P = 0.001); however, the count of tracheal aspirates was never greater than the count at baseline. No differences were found between tube types when the time course and cumulative counts of pharyngeal and tracheal samples were compared.
  
  
  CONCLUSIONS
  Small-bore nasogastric tubes in intubated patients do not reduce gastroesophageal reflux or microaspiration.
authors.affiliation: University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ferrer
authors.forename: T T
authors.initials: TT
authors.lastname: Bauer
authors.forename: A
authors.initials: A
authors.lastname: Torres
authors.forename: C
authors.initials: C
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: Piera
mesh_terms: D018592:Cross-Over Studies; D004867:Equipment Design; D005764:Gastroesophageal Reflux / Q000209:etiology / Q000517:prevention & control*; D005766:Gastrointestinal Contents; D006801:Humans; D001239:Inhalation; D007441:Intubation, Gastrointestinal / Q000009:adverse effects / Q000295:instrumentation*