[Chronic HCV hepatopathy and cryoglobulinemia. The associated clinical spectrum].
OBJECTIVE
The hepatitis C infection (HCV) has numerous extrahepatic manifestations owing to the systemic nature of the infection itself. HCV infects the cells that carry a CD 81 receptor and show a marked tropism for hepatocytes, bone marrow staminal cells and circulating lymphomonocytes. One consequence of this tropism is the activation of B lymphocyte clones with the consequent production of autoantibodies and cryoglobulins. The secondary event is the formation of circulating immune complexes which, having precipitated at an intravascular level, may cause part of the extrahepatic manifestations associated with these infections.


METHODS
This retrospective study evaluated the manifestations correlated and/or associated with HCV hepatitis and mixed cryoglobulinaemia.


RESULTS
This analysis showed that 75% of consecutively studied patients reveal clinically important extrahepatic manifestations.


CONCLUSIONS
This underlines the "broad spectrum" action played by the hepatitis C virus in the host organism.
Pellicano
R
R
Dipartimento di Gastroenterologia, Ospedale Molinette, Torino.
Leone
N
N
Maiocco
I A
IA
Modena
V
V
Arena
V
V
Marietti
G
G
Puiatti
P
P
Palmas
F
F
Rizzetto
M
M
Ponzetto
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003449:Cryoglobulinemia / Q000209:etiology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
Epatopatia cronica da HCV e crioglobulinemia. Lo spettro clinico associato.