[Effect of the ion composition of the calcium-free medium and cardiomyocyte damage during "calcium paradox" in rats].
The findings reveal that the degree of myocardial damage in the "calcium paradox" does not depend on the contracture strength, that the contracture attenuation due to a decreased concentration in the Ca-free medium is not equal to the cardiocytes protection as compared with other means. Mg2+ and the studied means of myocardial protection seem to play a major role in assessment of the "calcium paradox" development and explain the difference in results of the hyposodium medium effects in the "calcium paradox".
Alabovskiĭ
V V
VV
Voronezh State Medical Academy, Russia.
Dmitrashchuk
A I
AI
Vinokurov
A A
AA
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000378:metabolism; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D010477:Perfusion; D051381:Rats; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology
D002614:Chelating Agents; D004492:Edetic Acid; D012964:Sodium; D008274:Magnesium; D002118:Calcium
Vliianie ionnogo sostava beskal'tsievoĭ sredy i povrezhdeniie kardiomiotsitov krys pri kal'tsievom paradokse.