[Intrathecal humoral immune response in pediatric patients with meningoencephalitis due to Coxsackie B5].
BACKGROUND
Childhood is sensibly affected by viral meningoencephalitis outbreaks.


OBJECTIVE
To study the intrathecal humoral immune response in a group of children suffering from Coxsackie B5 meningoencephalitis outbreak. Patients and methods. Forty eight sick children were studied. Serum and cerebrospinal IgA, IgM, IgG and albumin were quantified by radial immunodiffusion. It had been evaluated by reibergrams.


RESULTS
Seventeen children has blood-cerebrospinal fluid barrier dysfunction. Four different patterns of intrathecal immune humoral response were observed mainly IgG and three major immunoglobulins class. Mean cell counts was 624 +/- 517 x 10(6) cells/l with a lymphocyte predominance.


CONCLUSIONS
An intrathecal humoral response were reported as an early patterns like in delayed non-diagnostic puncture and in evolutive puncture in adults patterns with viral meningoencephalitis.
Dorta-Contreras
A J
AJ
Laboratorio de Neuroinmunología, Hospital Pediátrico San Miguel del Padrón, La Habana, Cuba. adorta@infomed.sld.cu
Agüero-Valdés
E
E
Escobar-Pérez
X
X
Noris-García
E
E
Ferrá-Valdés
M
M
D000914:Antibodies, Viral / Q000134:cerebrospinal fluid / Q000276:immunology*; D000917:Antibody Formation / Q000276:immunology; D001812:Blood-Brain Barrier / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections; D029822:Enterovirus B, Human; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis* / Q000134:cerebrospinal fluid*; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000821:virology
D000914:Antibodies, Viral; D007136:Immunoglobulins
Respuesta inmune humoral intratecal en pacientes pediátricos con meningoencefalitis por Coxsackie B5.