title: [The appearance of giant negative T waves in anterior acute myocardial infarct with a Q wave is associated with minor myocardial damage and a minor extension of coronary disease].
abstract: OBJECTIVE
  The early inversion of T waves in patients with acute myocardial infarction has recently been related to a better left ventricular function and a more favourable evolution, contrary to what happens in the unstable angina. On the other hand, the significance of the appearance of deep negative T waves in the early phase of some acute myocardial infarction is not known. The aim of this study is to evaluate its relation with the existing myocardial damage and the underlying coronary artery disease extension in anterior some with Q wave.
  
  
  METHODS
  48 patients with a first anterior Q-wave acute myocardial infarction, thrombolized or not, admitted to hospital with an evolution of less than 24 hours, and with a coronariography performed before discharge were analyzed. Giant negative T waves were defined as those which were 8 mm or more from baseline.
  
  
  RESULTS
  17 of the 48 patients presented giant negative T waves (T-group) and 31 did not (N-group). In the T-group patients, the size of the negative T wave was 11.29 +/- 2.86 mm and the number of precordial leads with negative T waves was 4.35 +/- 1.57. There were no differences between both groups in variables such as sex, coronary risk factors, and other basal characteristics. The T-group patients were younger, had lower peak-CK, CK-MB and LDH levels and presented greater recovery of R waves during the follow-up, the differences being significant with the N-group patients. The left ventricular ejection fraction was higher (56.3 +/- 13.4 vs 42 +/- 12%; p < 0.001) and the number of affected coronary vessels was lower in the T-group (1.12 vs 1.64; p < 0.01); there were no differences in the localization or severity of coronary lesions, nor in the frequency of postinfarction myocardial angina. None of the patients in the T-group were Killip > I, while this situation occurred in 38.7% of the N-group patients.
  
  
  CONCLUSIONS
  The appearance of giant negative T waves in the acute or early phase of Q-wave anterior acute myocardial infarction is associated with a smaller infarct size, lower functional deterioration and less extension of the underlying coronary disease.
authors.affiliation: Servicio de Cardiología, Hospital Regional Universitario Infanta Cristina, Badajoz.
authors.forename: A
authors.initials: A
authors.lastname: Merchán Herrera
authors.forename: V
authors.initials: V
authors.lastname: Millán Núñez
authors.forename: J R
authors.initials: JR
authors.lastname: López Mínguez
authors.forename: A
authors.initials: A
authors.lastname: Cimbora Ortega
authors.forename: J J
authors.initials: JJ
authors.lastname: García Guerrero
authors.forename: R
authors.initials: R
authors.lastname: González Fernández
authors.forename: I
authors.initials: I
authors.lastname: Geniz Gallardo
authors.forename: J
authors.initials: J
authors.lastname: Fernández de la Concha
authors.forename: G
authors.initials: G
authors.lastname: Fernández Mora
authors.forename: F
authors.initials: F
authors.lastname: Alonso Ruiz
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis*; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
vernacular_title: La aparición de ondas T negativas gigantes en un infarto agudo de miocardio anterior con onda Q se asocia a un menor daño miocárdico y una menor extensión de la enfermedad coronaria.