Hydroxyurea treatment enhances metastatic cell adhesiveness: a possible chemotherapy-induced increase in metastatic potential?
Treatment of tumor cells with certain chemotherapeutic agents, including hydroxyurea, increases their metastatic potential. In the present study the adhesiveness of SW620 colonic metastasis cells treated with hydroxyurea was compared with untreated cells by measuring their ability to remain attached to tissue flask walls during gentle saline washes. Treatment of SW620 cells was found to significantly increase their adhesiveness, suggesting a mechanism by which hydroxyurea may enhance the metastatic potential of tumor cells.
Smith
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Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, UK.
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000473:pathology; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects / Q000494:pharmacology*; D009362:Neoplasm Metastasis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006918:Hydroxyurea