Kinetics of polymorphonuclear neutrophil infiltration after a traumatic brain injury in rat.
The aim of our study was to assess polymorphonuclear neutrophil infiltration into the injured parenchyma after a traumatic brain injury (TBI). Myeloperoxidase (MPO) activity was assayed on the hippocampus, temporal and parietal cortex 6, 24, 48, 72, and 120 h post-trauma. MPO activity occurred in these structures from 6 h post-trauma and was maximum at 24-48 h. It was resolved by 72 h in the hippocampus and the parietal cortex, but persisted in the temporal cortex until 120 h after trauma. This suggests that neutrophil infiltration is a delayed phenomenon in the physiopathology of TBI. Considering that a large therapeutic window may be crucial in the management of TBI, inhibition of neutrophil infiltration needs to be further investigated following cerebral trauma.
Royo
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Rhône-Poulenc Rorer S.A., Pharmaceutical Discovery, Ischemia/Trauma Dept., Vitry-sur-Seine, France.
Wahl
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Stutzmann
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JM
D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010296:Parietal Lobe / Q000473:pathology / Q000503:physiopathology*; D010474:Percussion; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors
D009195:Peroxidase