[Changes in blood levels of nitric oxide, oxidation and lipoperoxidation in patients with silicosis].
OBJECTIVE
To explore the relationship between nitric oxide, oxidation, lipoperoxidation and silicosis.


METHODS
Blood plasma levels of nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE), beta-carotene (P-beta-CAR), lipoperoxidase (P-LPO), and erythrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathione peroxidase (E-GSH-Px) and lipoperoxidase (E-LPO) were measured in 73 patients with silicosis and 60 healthy subjects.


RESULTS
The average levels of P-VC, P-VE, P-beta-CAR, E-SOD, E-CAT and E-GSH-Px were significantly lower and the average levels of P-NO, P-LPO and E-LPO significantly increased in the silicosis with varied severity of the disease and lung function status more than in the controls. There was linear relationship between all the above indices and length of the disease. Stepwise regression analysis showed that the severity of the disease and lung function status correlated most closely with the levels of P-NO, P-VE, E-SOD and E-LPO.


CONCLUSIONS
Metabolism of nitric oxide was abnormal, balance between oxidation and antioxidation was disturbed seriously, and oxidation and lipoperoxidation reaction pathologically exacerbated in the bodies of the patient with silicosis.
Zhou
J
J
Institute for Cardio- & Cerebro-vascular Diseases, Second Hospital, Zhejiang Medical University, Hangzhou.
Wu
D
D
Zhu
Y
Y
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010084:Oxidation-Reduction; D012044:Regression Analysis; D012494:Sampling Studies; D012829:Silicosis / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D001205:Ascorbic Acid