Turn up the HEAT.
The recently determined crystal structure of the PR65/A subunit of protein phosphatase 2A reveals the architecture of proteins containing HEAT repeats. The structural properties of this solenoid protein explain many functional characteristics and account for the involvement of solenoids as scaffold, anchoring and adaptor proteins.
Kobe
B
B
Structural Biology Laboratory, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia. B.Kobe@medicine.unimelb.edu.au
Gleichmann
T
T
Horne
J
J
Jennings
I G
IG
Scotney
P D
PD
Teh
T
T
D010749:Phosphoprotein Phosphatases / Q000737:chemistry*; D011487:Protein Conformation; D054648:Protein Phosphatase 2
D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2