title: Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits.
abstract: To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.
authors.affiliation: Department of Parasitology, Seoul National University College of Medicine and Medical Research Center, Korea.
authors.forename: D
authors.initials: D
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Lim
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: E Y
authors.initials: EY
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: S T
authors.initials: ST
authors.lastname: Hong
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000473:pathology; D003003:Clonorchiasis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D004108:Dilatation, Pathologic; D007411:Intestinal Diseases, Parasitic / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology*; D011223:Praziquantel / Q000627:therapeutic use; D011817:Rabbits; D018084:Ultrasonography, Interventional
chemical_list: D000980:Antiplatyhelmintic Agents; D011223:Praziquantel