Electrical stimulation of the horizontal limb of the diagonal band of broca modulates population EPSPs in piriform cortex.
Electrical stimulation of the horizontal limb of the diagonal band of Broca (HDB) was coupled with recording of evoked potentials in the piriform cortex. Stimulation of the HDB caused an enhancement of the late, disynaptic component of the evoked potential elicited by stimulation of the lateral olfactory tract but caused a suppression of the synaptic potential elicited by stimulation of the posterior piriform cortex. The muscarinic antagonist scopolamine blocked both effects of HDB stimulation. The enhancement of disynaptic potentials could be due to cholinergic depolarization of pyramidal cells, whereas the suppression of potentials evoked by posterior piriform stimulation could be due to presynaptic inhibition of intrinsic fiber synaptic transmission by acetylcholine.
Linster
C
C
Department of Psychology and Program in Neuroscience, Harvard University, Cambridge, Massachusetts 02138, USA.
Wyble
B P
BP
Hasselmo
M E
ME
D000818:Animals; D004558:Electric Stimulation; D018728:Entorhinal Cortex / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009830:Olfactory Bulb / Q000502:physiology; D009833:Olfactory Pathways / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000502:physiology; D017966:Pyramidal Cells / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000502:physiology
D018727:Muscarinic Antagonists; D012601:Scopolamine