Cell surface expression of MHC molecules in glioma cells infected with herpes simplex virus type-1.
9L glioma cells consistently expressed major histocompatibility complex (MHC) class I but not class II molecules. Herpes simplex type-1 virus (HSV-1) infection significantly reduced the expression of MHC I on the cell surface. Recombinant interferons could enhance the cell-surface expression of MHC I but had no effect on MHC II. This enhancement was partially inhibited by HSV-1 infection. HSV-1 mutants with deletions in ICP4, ICP6, ICP27, ICP47 and UL41 genes do not affect the infection induced inhibition, suggest that a different mechanism may be employed in the inhibition of cell-surface expression of MHC molecules.
Song
G Y
GY
Department of Surgery, University of British Columbia, Vancouver, Canada.
DeJong
G
G
Jia
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D000818:Animals; D000954:Antigens, Surface / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D005434:Flow Cytometry; D017353:Gene Deletion; D015967:Gene Expression Regulation, Viral / Q000276:immunology; D005814:Genes, Viral / Q000276:immunology; D018316:Gliosarcoma / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D016898:Interferon-alpha / Q000494:pharmacology; D016899:Interferon-beta / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured / Q000737:chemistry / Q000276:immunology / Q000378:metabolism
D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D016898:Interferon-alpha; D016899:Interferon-beta; D007371:Interferon-gamma