Crosslinked polyanhydrides for use in orthopedic applications: degradation behavior and mechanics.
High-strength, surface-eroding polymers were synthesized from methacrylated anhydride monomers of sebacic acid (MSA) and 1,6-bis(carboxyphenoxy) hexane (MCPH). These multifunctional monomers were photopolymerized using ultraviolet light to produce highly crosslinked polyanhydride networks. Through this approach, the crosslinking density of the resulting polymer network was used to control the final mechanical properties, while the degradation time scale was controlled by the chemical composition of the network. The combined hydrophobicity of the polymer backbone with the hydrolytically labile anhydride linkages led to surface-eroding networks, as confirmed by linear cumulative mass loss profiles as a function of degradation time for crosslinked polymer disks. By copolymerizing varying amounts of MSA and MCPH, the degradation rate of the final network was controlled from 2 days to 1 year. The tensile modulus of crosslinked poly(MSA) (1.4 GPa) was nearly an order of magnitude larger than that of linear poly(sebacic acid). In general, the mechanical properties of the crosslinked polyanhydrides networks were within ranges of those reported for cortical and trabecular bone. However, unlike bulk degrading polyesters such as poly(lactic acid), these surface eroding networks maintained >70% of their tensile modulus with 50% mass degradation.
Muggli
D S
DS
Department of Chemical Engineering, University of Colorado, Boulder 80309-0424, USA.
Burkoth
A K
AK
Anseth
K S
KS
D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D018786:Bone Substitutes; D003432:Cross-Linking Reagents; D003652:Decanoic Acids / Q000737:chemistry; D003998:Dicarboxylic Acids; D006586:Hexanes / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D009985:Orthopedics; D011108:Polymers / Q000138:chemical synthesis; D013718:Tensile Strength; D014466:Ultraviolet Rays
C120991:1,6-bis(carboxyphenoxy)hexane; D000180:Acrylic Resins; D000812:Anhydrides; D018786:Bone Substitutes; D003432:Cross-Linking Reagents; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D006586:Hexanes; D011108:Polymers; C011107:sebacic acid