Effect of 6 beta-methylprednisolone on mouse pregnancy rate.
The aim of this study was to evaluate the effect of methyl-prednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 microgram/g of 6 beta-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.
Velilla
E
E
Departament de Biologia Cellular i Fisiologia, Universitat Autònoma de Barcelona, Spain.
Grossmann
M
M
Egozcue
J
J
Santaló
J
J
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004624:Embryo Transfer; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000453:epidemiology; D005938:Glucocorticoids / Q000494:pharmacology*; D007107:Immune System / Q000187:drug effects; D007074:Immunoglobulin G / Q000378:metabolism; D015994:Incidence; D008775:Methylprednisolone / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D018873:Pregnancy Rate; D011270:Pregnancy, Animal / Q000187:drug effects*
D005938:Glucocorticoids; D007074:Immunoglobulin G; D008775:Methylprednisolone