title: Inner ear damage in guinea pigs exposed to stable and impulse noise.
abstract: OBJECTIVE
  To investigate the inner ear damage after exposure to stable noise, impulse noise and stable plus impulse noise in guinea pigs.
  
  
  METHODS
  Ninety-six healthy guinea pigs were divided into 3 equal groups. (1) Stable noise group: exposed to 110 dBA stable noise for 3 days, 4 hours per day. (2) Impulse noise group: exposed to 165 dBA simulated cannon fire impulse noise 10 times successively at an interval of 10 seconds. (3) stable plus impulse noise group: exposed to the same stable noise as that in the first group, then after a 2-hour rest, the animals were followed with impulse noise exposures as that in the second group. After those exposure, each of the 3 groups was further divided into 4 subgroups according to the time after the noise exposure, namely, the right after, 7 d, 14 d and 30 d groups. The evoked cortical potential responses to click and tone burst stimulation sound were examined. The surface preparation and celloidine embedded serial section of the cochlea were observed under a light microscope.
  
  
  RESULTS
  Both the stable and impulse noise could increase the hearing threshold and damage the inner ear hair cells. The damage in the first group was relatively slight, whereas in group 3 the damage was more severe than that in the other 2 groups.
  
  
  CONCLUSIONS
  For seamen who are working in heavy noise environment, corresponding measures should be taken to protect their ears from noise which induces hearing loss.
authors.affiliation: Department of Otorhinolaryngology, Navy General Hospital, PLA, Beijing, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Jiang
authors.forename: P
authors.initials: P
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D007758:Ear, Inner / Q000473:pathology*; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000503:physiopathology; D009622:Noise / Q000009:adverse effects*; D014432:Tympanic Membrane / Q000473:pathology