Efficacy, tolerability, and rare side effects of tibolone treatment in postmenopausal women.
OBJECTIVE
The purpose of this study was to assess the tolerability and side effects of tibolone (Livial, Organon), a synthetic steroid analogue for the treatment of postmenopausal symptoms, in a large population of patients.


METHODS
1189 postmenopausal patients were included in this study. The patients' blood pressure, body weight, general complaints, and the severity of their climacteric complaints were documented at baseline and after 4 months of tibolone treatment.


RESULTS
Tibolone significantly relieved all of the classical menopausal complaints. The proportion of patients with bleeding problems dropped significantly from 15.9% to 6.8%. Other complaints, such as headache, vertigo, nervousness, breast tenderness, and hirsutism were also significantly less frequent than before treatment. Only few women reported other rare side effects, and only 14.4% of women discontinued treatment prematurely.


CONCLUSIONS
Tibolone provides an efficient and safe means of treating the postmenopausal syndrome in every-day practice.
Egarter
C
C
Department of Obstetrics and Gynecology, University of Vienna, Währinger Gürtel, Austria.
Sator
M
M
Berghammer
P
P
Huber
J
J
D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000009:adverse effects / Q000627:therapeutic use*; D017698:Postmenopause; D011446:Prospective Studies
D018931:Antineoplastic Agents, Hormonal; D009652:Norpregnenes; C027385:tibolone