Biology of IL-8-induced stem cell mobilization.
The CXC chemokine interleukin-8 (IL-8) has profound hematopoietic activities following systemic administration. It induces the rapid mobilization of cells with lymphomyeloid repopulating ability in mice and of hematopoietic progenitor cells in monkeys. In this paper, evidence is presented that stem cell mobilization in mice requires the functional expression on the beta 2-integrin leukocyte function-associated antigen-1 (LFA-1). In monkeys, systemic injection of IL-8 is followed by a significant increase in the circulating levels of the matrix metallo proteinase gelatinase-B (MMP-9). Based on these findings, the hypothesis is discussed that mature neutrophils serve as intermediate cells in IL-8-induced stem cell mobilization by the release of proteinases.
Fibbe
W E
WE
Department of Hematology, Leiden University Medical Center, The Netherlands. wfibbe@hematology.azl.nl
Pruijt
J F
JF
Velders
G A
GA
Opdenakker
G
G
van Kooyk
Y
Y
Figdor
C G
CG
Willemze
R
R
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D016209:Interleukin-8 / Q000494:pharmacology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000096:biosynthesis; D008253:Macaca mulatta; D008666:Metalloendopeptidases / Q000378:metabolism; D051379:Mice
D015815:Cell Adhesion Molecules; D016209:Interleukin-8; D016169:Lymphocyte Function-Associated Antigen-1; D008666:Metalloendopeptidases