B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality.
We studied the susceptibility of B cell-deficient mice to encephalomyelitis following intraperitoneal inoculation of HSV-1. B cell-deficient mice developed striking CNS signs including tail atony, clumsy gait and limb paralysis after HSV-1 infection. In addition, B cell-deficient mice had decreased survival (LD50 = 2.2 x 10(7) PFU) compared to control C57BL/6 mice (LD50 = 2.3 x 10(8) PFU). B cell-deficient mice had encephalomyelitis and detectable virus in the brain 7 days post-infection while C57BL/6 mice did not. Passive transfer of hyperimmune sera protected B cell-deficient mice from death, suggesting a role for antibody in susceptibility to HSV-1 encephalomyelitis.
Beland
J L
JL
Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sobel
R A
RA
Adler
H
H
Del-Pan
N C
NC
Rimm
I J
IJ
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000821:virology; D004198:Disease Susceptibility; D018792:Encephalitis, Viral / Q000276:immunology* / Q000401:mortality; D004679:Encephalomyelitis / Q000276:immunology* / Q000401:mortality; D006561:Herpes Simplex / Q000276:immunology* / Q000401:mortality; D018259:Herpesvirus 1, Human / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D016019:Survival Analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000821:virology