Bone marrow pre-B-1 (Bomb1): a quantitative trait locus inducing bone marrow pre-B-cell expansion in lymphoma-prone SL/Kh mice.
Abnormalities of regulatory genes in early B-cell development often lead to lymphomagenesis. Our previous study showed that there is an abnormal transient expansion of bone marrow (BM) pre-B cells in lymphoma-prone SL/Kh strain mice. Such expansion is a genetic property of SL/Kh stem cells rather than BM microenvironments. Using the percentage of BP1+ B220+ pre-B cells in total BM lymphoid cells as a quantitative parameter, we studied the genetic control of BM pre-B cells in 159 F2 offspring of crosses between SL/Kh and NFS/N mice and 334 back-crosses to SL/Kh mice. A highly significant quantitative trait locus was identified on the distal segment of chromosome 3, showing logarithm of odds scores of 22.7 in the F2 cohort and 10.7 in back-cross mice. This quantitative trait locus, named bone marrow pre-B-1, colocalized with lymphoid enhancer factor-1, which encodes a high mobility group DNA-binding protein that is expressed in T and pre-B cells.
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Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, Japan.
Shimada
R
R
Higashi
S
S
Zeng
Z
Z
Hiai
H
H
D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D012737:Sex Factors
D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D005819:Genetic Markers