title: Identification and characterization of brt1, a gene down-regulated during B-regulated development in Schizophyllum commune.
abstract: To identify genes regulated by the B mating-type genes a differential RNA display was established for the homobasidiomycete Schizophyllum commune and a gene, brt1, was identified. The mRNA concerned is highly abundant in monokaryotic mycelia and is down-regulated in matings in which either the B genes alone or else both the A and B genes are different between the mates. This places the gene brt1 under the control of the pheromone response system of S. commune encoded by the B mating-type loci. Sequence analysis revealed similarity to a novel protein family, two members of which have been shown to inhibit translational re-initiation.
authors.affiliation: Friedrich-Schiller-Universität, Biologisch-Pharmazeutische Fakultät, Institut für Mikrobiologie, Mikrobielle Phytopathologie, Beutenbergstrasse 11, D-07745 Jena, Germany.
authors.forename: K B
authors.initials: KB
authors.lastname: Lengeler
authors.forename: E
authors.initials: E
authors.lastname: Kothe
mesh_terms: D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003433:Crosses, Genetic; D015245:Deoxyribonuclease BamHI / Q000235:genetics; D015536:Down-Regulation; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005819:Genetic Markers; D005821:Genetic Techniques; D017403:In Situ Hybridization / Q000379:methods; D008969:Molecular Sequence Data; D012331:RNA, Fungal; D012098:Reproduction / Q000235:genetics; D012567:Schizophyllum / Q000235:genetics* / Q000254:growth & development; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic
chemical_list: C120380:BRT1 protein, Schizophyllum commune; D005656:Fungal Proteins; D005819:Genetic Markers; D012331:RNA, Fungal; D015245:Deoxyribonuclease BamHI