Future strategies in external radiation therapy of renal cell carcinoma.
The advantage of external radiation therapy in renal cell carcinoma is controversial. High complication rates reported in previous trials of postoperative radiation therapy can now be avoided by using contemporary modern treatment techniques. Based on both prospective and retrospective data the following indications for adjuvant radiation therapy should be considered and tested in phase III trials: a) unresectable non-metastatic tumours (preoperative irradiation), b) incomplete resection with gross or macroscopically positive margins, c) locally advanced tumour with perinephric fat extension or adrenal invasion.
Kortmann
R D
RD
Department of Radiotherapy, University of Tuebingen, Germany. rolf.kortmann@uni-tuebingen.de
Becker
G
G
Classen
J
J
Bamberg
M
M
D002292:Carcinoma, Renal Cell / Q000532:radiotherapy* / Q000601:surgery; D017326:Clinical Trials, Phase III as Topic; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*