[Microbiological synthesis of virazole by immobilized cells].
Based on the isotherms of adsorption of the cells of Xanthomonas campestris B-610 to glass and polyvinyl fibers, immobilized systems were produced, in which the cell content was sufficient for enzymatic synthesis of Virazole (1-[beta-D-ribofuranosyl]-1,2,4-triazole-3-carboxamide) using adenosine as a donor of ribose (50-60% conversion of 1,2,4-triazole-3-carboxamide). The immobilized cells thus obtained retain their enzymatic activity for six months and can be used repeatedly.
Iaskovich
G A
GA
State Academy of Chemistry and Pharmaceutics, St. Petersburg, Russia.
Iakovleva
E P
EP
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000378:metabolism; D002384:Catalysis; D018914:Cells, Immobilized / Q000378:metabolism; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D012254:Ribavirin / Q000302:isolation & purification* / Q000378:metabolism; D013939:Thymidine Phosphorylase / Q000378:metabolism; D014543:Uridine Phosphorylase / Q000378:metabolism; D016959:Xanthomonas campestris / Q000378:metabolism
D000998:Antiviral Agents; D012254:Ribavirin; D011683:Purine-Nucleoside Phosphorylase; D014543:Uridine Phosphorylase; D013939:Thymidine Phosphorylase
Mikrobiologicheskiĭ sintez virazola immobilizovannymi kletkami.