title: Presenilins in their infancy.
abstract: Familial forms of Alzheimer's disease are caused by mutations in the genes encoding the presenilins, which are integral membrane proteins. Presenilins have been shown to interact with beta-amyloid precursor proteins and Notch receptors. Several recent studies have examined the role of presenilins in Notch processing.
authors.affiliation: Ecole Normale Supérieure, CNRS ATIPE UMR8544, 46, rue d'Ulm, 75230, Paris, Cedex 05, France. schweisg@wotan.ens.fr
authors.forename: F
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D053764:Presenilin-1; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch
chemical_list: D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D011956:Receptors, Cell Surface; D051880:Receptors, Notch