title: Spectral properties of EEG fast activity ictal discharges associated with infantile spasms.
abstract: OBJECTIVE
  The aim of this study was to evaluate the characteristics of the ictal EEG event accompanying infantile spasms.
  
  
  METHODS
  Quantitative analysis was used, based on the application of a bivariate autoregressive (AR) parametric model; autospectra, coherence, phase functions and inter-hemispheric time differences were estimated on homologous EEG channels in 18 infants presenting with either cryptogenic or symptomatic West syndrome.
  
  
  RESULTS
  The AR analysis of the 500 ms EEG epochs preceding spasm onset revealed the presence of a short discharge of fast activity restricted to a narrow frequency band in 13 of the 18 cases included in the study. The fast discharge peaked at 17.5+/-2.1 Hz, with rather low inter-hemispheric coherence values (0.52+/-0.17) and asymmetric amplitude on homologous EEG derivations. It persisted briefly after spasm onset, reaching a higher coherence value (0.71+/-0.16). The inter-hemispheric time difference, estimated in those cases with the coherence values significantly different from zero, ranged from 9.1 to 14.3 ms (11.4+/-1.9) in the epoch preceding spasm onset.
  
  
  CONCLUSIONS
  The data obtained from the analysis of the ictal EEG events, compared with clinical and interictal EEG features, indicate that an asymmetric EEG pattern (mainly consisting of a rhythmic burst of fast activity) consistently preceded both symmetric and asymmetric spasms, thus suggesting a localized cortical origin of the ictal discharge giving rise to the spasms.
authors.affiliation: Department of Neurophysiology, C. Besta Neurological Institute, Milan, Italy. panzica@mail.cilea.it
authors.forename: F
authors.initials: F
authors.lastname: Panzica
authors.forename: S
authors.initials: S
authors.lastname: Franceschetti
authors.forename: S
authors.initials: S
authors.lastname: Binelli
authors.forename: L
authors.initials: L
authors.lastname: Canafoglia
authors.forename: T
authors.initials: T
authors.lastname: Granata
authors.forename: G
authors.initials: G
authors.lastname: Avanzini
mesh_terms: D017668:Age of Onset; D001921:Brain / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D013036:Spasms, Infantile / Q000503:physiopathology*