Effects of indomethacin on joint damage in rat and rabbit.
OBJECTIVE
To study the effects of indometacin (Ind) on joint damages.


METHODS
The volume of noninjected hind paw and interleukin-1 (IL-1) production from peritoneal macrophages and articular synoviocytes induced by lipopolysaccharides were assayed in adjuvant arthritis (AA) rats. Measurements of synovial fibroblast proliferative response and proteoglycan synthesis of cartilage from rabbits were used.


RESULTS
The secondary inflammatory reactions in AA rats on d 18, 21, and 24 were suppressed by i.g. Ind 2 mg.kg-1.d-1 for 9 d. Ind promoted IL-1 production from both macrophages and synoviocytes in AA rats. Ind 10 mumol.L-1 enhanced the proliferation of rabbit synovial fibroblasts and suppressed the proteoglycan synthesis of articular cartilage in response to IL-1 in vitro.


CONCLUSIONS
Ind is unfavorable to the repair of joint destruction.
Wang
B
B
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
Yao
Y Y
YY
Chen
M Z
MZ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology; D007213:Indomethacin / Q000494:pharmacology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D017737:Macrophages, Peritoneal / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011509:Proteoglycans / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D011509:Proteoglycans; D007213:Indomethacin