Methotrexate treatment for retained placental tissue.
Three cases of placental polyps not responding to conventional medical and surgical treatment are presented. In all three cases, hCG in serum was negative but despite this a single injection of methotrexate successfully treated the condition. It is suggested that methotrexate acts not only on dividing trophoblastic cells but also has other effects.
Flam
F
F
Department of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden.
Karlström
P O
PO
Carlsson
B
B
Garoff
L
L
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D005260:Female; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D018457:Placenta, Retained / Q000188:drug therapy*; D011247:Pregnancy
D000020:Abortifacient Agents, Nonsteroidal; D005493:Folic Acid Antagonists; D019384:Nucleic Acid Synthesis Inhibitors; D008727:Methotrexate