Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients.
Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.
Silva
J M
JM
Department of Medical Oncology, Clinica Puerta de Hierro, Madrid, Spain.
Dominguez
G
G
Villanueva
M J
MJ
Gonzalez
R
R
Garcia
J M
JM
Corbacho
C
C
Provencio
M
M
España
P
P
Bonilla
F
F
D000595:Amino Acid Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000097:blood*; D005260:Female; D019942:Genes, p16 / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D004273:DNA, Neoplasm