Effect of procainamide on ultrastructure of blood platelet in rabbits.
OBJECTIVE
To study the effect of procainamide (PA) on the ultrastructure of blood platelets.


METHODS
Arachidonic acid was added to PA-treated platelet-rich plasma to induce platelet aggregation. The 50-nm sections were examined with a transmission electron microscope.


RESULTS
PA 8.5-136 mumol.L-1 markedly inhibited changes of pseudopods, alpha-granules, dense granules, glycogens, open canalicular system, and dense tubular system.


CONCLUSIONS
PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.
Liu
L P
LP
Department of Electron Microscopy, First Military Medical University, Guangzhou, China.
Shan
C W
CW
Liu
X H
XH
Xiao
H C
HC
Yang
S Q
SQ
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011342:Procainamide / Q000494:pharmacology*; D011817:Rabbits
D010975:Platelet Aggregation Inhibitors; D011342:Procainamide