Nuclear import of human immunodeficiency virus type-1 preintegration complexes.
Following infection-mediated entry into the cytoplasm, retroviral cores form large nucleoprotein complexes (PICs) which undergo reverse transcription and, ultimately, catalyze provirus formation. The ability of these complexes to be specifically imported into the nucleus via NPCs explains why nondividing cells can be productively infected with lentiviruses such as HIV-1, whereas productive infection by the oncoretrovirus MLV is restricted to proliferating cells. Current evidence suggests that virally encoded protein components of the HIV-1 PIC, in particular IN and Vpr, act in concert to target these complexes for nuclear import by recruiting cellular import factors and interacting with the NPCs. Here have we reviewed recent advances made in this complex and fascinating area of HIV-1 biology and have discussed them in relation to models for postentry nuclear import in other retroviral and nonretroviral systems.
Fouchier
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RA
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia 19104-6148, USA.
Malim
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MH
D000256:Adenoviridae / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002453:Cell Cycle; D002467:Cell Nucleus / Q000378:metabolism; D004279:DNA, Viral; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D006801:Humans; D008954:Models, Biological; D019913:Nuclear Localization Signals; D012192:Retroviridae Infections / Q000821:virology; D013539:Simian virus 40 / Q000378:metabolism; D016092:Spumavirus / Q000472:pathogenicity; D014764:Viral Proteins / Q000378:metabolism; D016662:Virus Integration
D004279:DNA, Viral; D019913:Nuclear Localization Signals; D014764:Viral Proteins