title: [The stimulating effect of destabilase, a component of Hirudo medicinalis salivary gland secretion, on sensory neuron neurite growth in organotypic culture].
abstract: The effect of destabilase, a component of Hirudo medicinalis salivary gland secret, was investigated in organotypic tissue culture of dorsal root ganglia (DRG) of 10-11-day old chick embryos. Native destabilase in concentrations 0.01 and 0.05 ng/ml was active, inducing a more intensive neurite growth in DRG that in the control. The stabilizing activity of destabilase was lost following reverse-phase chromatography. Neurite-stimulating effects of the drug "pyjavit" is due presumably to neurite-stimulating activity of destabilase.
authors.affiliation: Institute of Physiology, Russian Academy of Sciences, and Medical Institute, St. Petersburg.
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: S G
authors.initials: SG
authors.lastname: Zhuravskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Penniiaĭnen
authors.forename: S N
authors.initials: SN
authors.lastname: Berezhnoĭ
authors.forename: I I
authors.initials: II
authors.lastname: Artamonova
authors.forename: L L
authors.initials: LL
authors.lastname: Zavalova
authors.forename: I P
authors.initials: IP
authors.lastname: Baskova
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D010450:Endopeptidases / Q000494:pharmacology*; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000187:drug effects*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D007865:Leeches; D009414:Nerve Growth Factors / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects* / Q000648:ultrastructure; D012469:Salivary Glands / Q000378:metabolism*; D013268:Stimulation, Chemical
chemical_list: D009414:Nerve Growth Factors; D010450:Endopeptidases; C045348:fibrin destabilase
vernacular_title: Stimuliruiushchee vliianie destabilazy, komponenta sekreta, sliunnykh zhelez meditsinskoĭ piiavki, na rost neĭritov chuvstvitel'nykh neĭronov v organotipicheskoĭ kul'ture.