title: Inhibitory effects of procainamide on rabbit platelet aggregation and thromboxane B2 production in vitro.
abstract: OBJECTIVE
  To study the influences of procainamide (PA) on thrombin-induced rabbit platelet aggregation and thromboxane B2 (TXB2) production in vitro.
  
  
  METHODS
  Turbidimetry and radioimmunoassay were used.
  
  
  RESULTS
  PA 8.5, 34, 136, and 544 mumol.L-1 inhibited thrombin-induced platelet aggregation and TXB2 production, and the inhibitory rates were 45% +/- 37%, 48% +/- 32%, 88% +/- 23%, 92% +/- 15% and 53% +/- 24%, 65% +/- 26%, 90% +/- 6%, 95% +/- 6%, respectively. There was positive correlation between PA concentration and efficiency of inhibition of platelet aggregation and TXB2 production, and also between the inhibition % of platelet aggregation and that of production of TXB2. The three linear equations and main parameters were Y = 0.2075X-4.9157, r = 0.9985; Y = 0.9546X-34.6724, r = 0.9921; Y = 0.8202X + 19.7062, r = 0.9921.
  
  
  CONCLUSIONS
  PA inhibited thrombin-induced platelet aggregation and TXB2 production in rabbits.
authors.affiliation: Department of Pharmacology, First Military Medical University, Guangzhou, China.
authors.forename: C W
authors.initials: CW
authors.lastname: Shan
authors.forename: J H
authors.initials: JH
authors.lastname: Lin
authors.forename: Y H
authors.initials: YH
authors.lastname: Jin
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011342:Procainamide / Q000494:pharmacology*; D011817:Rabbits; D013929:Thromboxane B2 / Q000096:biosynthesis*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D011342:Procainamide