Cytological and immunocytochemical evaluation of thyroid and breast masses in patients with a previous neoplasm: case reports.
The diagnosis of secondary tumours represents one of the most important fields in the application of fine needle aspiration cytology (FNAC). We studied two patients, one with a history of breast cancer and one with a previous tumour of the thyroid, who showed a second mass, in the thyroid and in the breast, respectively, during follow up. The aim of our study was to evaluate if cytology, performed on FNAC smears, may distinguish a metastatic lesion from a second primary tumour, or if further immunocytochemistry should be performed. Our data demonstrate that, while cytology may be indicative of a second primary tumour, the histotype should be confirmed by immunocytochemical staining.
Pisani
T
T
Department of Experimental Medicine, University of Rome La Sapienza, Italy.
Antonaci
A
A
Sinopoli
N T
NT
Mottolese
M
M
Vecchione
A
A
Giovagnoli
M R
MR
D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005656:Fungal Proteins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology*; D029701:Saccharomyces cerevisiae Proteins; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D000911:Antibodies, Monoclonal; D005656:Fungal Proteins; C087579:MBR1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D016159:Tumor Suppressor Protein p53; D013954:Thyroglobulin