Anti-emetic principles of Pogostemon cablin (Blanco) Benth.
Bioassay-guided fractionation of anti-emetic extracts and constituents of 8 traditional Chinese herbal drugs was performed. Twenty extracts described in Table 1 showed anti-emetic activity on copper sulfate induced-emesis in young chicks. From the n-hexane extract of Pogostemon cablin, patchouli alcohol (1), pogostol (2), stigmast-4-en-3-one (3), retusin (4), and pachypodol (5) were tested and exhibited anti-emetic effects.
Yang
Y
Y
Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
Kinoshita
K
K
Koyama
K
K
Takahashi
K
K
Tai
T
T
Nunoura
Y
Y
Watanabe
K
K
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D002645:Chickens; D019327:Copper Sulfate / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male
D000932:Antiemetics; D004365:Drugs, Chinese Herbal; D019327:Copper Sulfate