[VEGF in therapeutic coronary and peripheral artery angiogenesis].
An overview is presented of the various steps of angiogenesis, to which an important contributor is Vascular Endothelial Growth Factor (VEGF), a substance capable of increasing both the permeability and the mitosis rate of endothelial cells. VEGF is also a potent vasodilating agent. The beneficial effects of these properties on the ischemic vasculature have been documented in numerous animal models, leading to the concept of angiogenesis-enhancement as a therapeutic tool. The first clinical trials are under way. This area is discussed based on a literature review.
Elbaz
M
M
Service de Cardiologie, CHU Purpan, Toulouse, France.
Malavaud
B
B
D000818:Animals; D002199:Capillary Permeability; D016228:Endothelial Growth Factors / Q000502:physiology* / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D008222:Lymphokines / Q000502:physiology* / Q000627:therapeutic use*; D018919:Neovascularization, Physiologic; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D014665:Vasodilator Agents / Q000627:therapeutic use
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D014665:Vasodilator Agents
Le VEGF dans l'angiogenèse thérapeutique coronaire et vasculaire périphérique.