title: EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis.
abstract: Ethylene regulates plant growth, development, and responsiveness to a variety of stresses. Cloning of the Arabidopsis EIN2 gene identifies a central component of the ethylene signaling pathway. The amino-terminal integral membrane domain of EIN2 shows similarity to the disease-related Nramp family of metal-ion transporters. Expression of the EIN2 CEND is sufficient to constitutively activate ethylene responses and restores responsiveness to jasmonic acid and paraquat-induced oxygen radicals to mutant plants. EIN2 is thus recognized as a molecular link between previously distinct hormone response pathways. Plants may use a combinatorial mechanism for assessing various stresses by enlisting a common set of signaling molecules.
authors.affiliation: Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Alonso
authors.forename: T
authors.initials: T
authors.lastname: Hirayama
authors.forename: G
authors.initials: G
authors.lastname: Roman
authors.forename: S
authors.initials: S
authors.lastname: Nourizadeh
authors.forename: J R
authors.initials: JR
authors.lastname: Ecker
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000737:chemistry / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D029681:Arabidopsis Proteins; D002352:Carrier Proteins / Q000737:chemistry; D027682:Cation Transport Proteins; D003001:Cloning, Molecular; D003517:Cyclopentanes / Q000378:metabolism / Q000494:pharmacology; D004268:DNA-Binding Proteins; D023082:Defensins; D005030:Ethylenes / Q000378:metabolism* / Q000494:pharmacology; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D005816:Genetic Complementation Test; D006540:Herbicides / Q000494:pharmacology; D033862:Iron-Binding Proteins; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008861:Microsomes / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D009687:Nuclear Proteins / Q000502:physiology; D054883:Oxylipins; D010269:Paraquat / Q000494:pharmacology; D010937:Plant Growth Regulators / Q000378:metabolism* / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D030821:Plants, Genetically Modified; D014176:Protein Biosynthesis; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D029681:Arabidopsis Proteins; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D003517:Cyclopentanes; D004268:DNA-Binding Proteins; D023082:Defensins; D005030:Ethylenes; D006540:Herbicides; D033862:Iron-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D054883:Oxylipins; D010269:Paraquat; D010937:Plant Growth Regulators; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2; C119963:EIN2 protein, Arabidopsis; C106987:EIN3 protein, Arabidopsis; C011006:jasmonic acid; C036216:ethylene