Prevalence of prostatic intraepithelial (PIN) in surgical resections.
OBJECTIVE
To determine the prevalence of prostatic intraepithelial neoplasia (PIN) in surgical specimens and assess its relationship to adenocarcinoma.


METHODS
205 surgical specimens (191) transurethral resections, 6 open prostatectomies, 8 needle biopsies) reported at the University Department of Pathology, Colombo over 64 months were reviewed.


RESULTS
There were 170 benign hyperplasias and 35 adenocarcinomas. PIN I was present in 22.92% PIN II in 5.36% and PIN III in 7.32% of the specimens. 8.51%, 27.27% and 93.3% PIN I, PIN II and III were associated with invasive adenocarcinoma. Nine cases (4.39%) had high grade PIN (PIN II & III) in the absence of adenocarcinoma.


CONCLUSIONS
PIN II & III were strongly associated with coexistent carcinoma but PIN I was not. The finding of high grade PIN in surgical biopsies with no obvious adenocarcinoma warrants examination of all available tissue and deep sections.
de Silva
M V
MV
Dept. of Pathology, Faculty of Medicine, University of Colombo, Sri Lanka.
Fernando
M S
MS
Abeygunasekera
A M
AM
Serozsha Goonewardene
S A
SA
D000230:Adenocarcinoma / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D008297:Male; D015995:Prevalence; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000601:surgery