[Determination of basic drugs in blood by RP-HPLC].
A reversed-phase HPLC method for determination of phenothiazines and tricyclin antidepressants in whole blood was described. In this paper, a model 1090 HPLC with DAD and a zorbax ODS column was used. The mobile phase was methanol: water: tritely amine (75:24.7:0.3) with pH 7.5. Cyproheptadine was used as internal standard in this method. Blood samples were extracted with the solid-phase extraction method and the liquid-liquid method. This method is suitable in forensic toxicology analysis for basic drugs.
Zhuo
X
X
Institute of Forensic Sciences, Ministry of Justice, Shanghai.
Wu
H
H
Liu
W
W
Huang
Z
Z
D000929:Antidepressive Agents, Tricyclic / Q000097:blood*; D014150:Antipsychotic Agents / Q000097:blood*; D002746:Chlorpromazine / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004316:Doxepin / Q000097:blood; D006801:Humans; D010546:Perphenazine / Q000097:blood
D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D004316:Doxepin; D010546:Perphenazine; D002746:Chlorpromazine