[Role of fibroblast growth factor-2 in tumor angiogenesis].
Angiogenesis reflects a balance between stimulating and inhibitory factors, among which fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) play a central role. FGF-2 stimulates endothelial cell growth and migration and enhances angiogenesis, both in vitro and in vivo. FGF-2 binds to a specific receptor (FGF R1) at the surface of endothelial cells. In addition to its extracellular effects, FGF-2 exerts intracellular effects that seem to be independent from tyrosine kinase-type receptors. FGF-2 is produced by several tumor types, including brain tumors, skin tumors, and fibrosarcomas. FGF-2 may play a pivotal role in angiogenesis in these tumors.
Bikfalvi
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Laboratoire des Facteurs de Croissance et de la Différenciation Cellulaire, Faculté des Sciences, Université Bordeaux I, Talence, France.
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000502:physiology*; D006801:Humans; D009389:Neovascularization, Pathologic
D016222:Fibroblast Growth Factor 2
Le rôle du facteur de croissance des fibroblastes-2 dans l'angiogenése tumorale.