The novel structural protein of human cytomegalovirus, pUL25, is localized in the viral tegument.
Human cytomegalovirus UL25 codes for a structural phosphoprotein of 85 kDa (C. J. Baldick and T. Shenk, J. Virol. 70:6097-6105, 1996; M. C. Battista et al., J. Virol. 73:3800-3809, 1999). In this study we analyzed the intracellular and intraviral localization of pUL25 by confocal and immunoelectron microscopy and found that pUL25 is a component of the viral tegument and the dense body matrix, acquired during the late cytoplasmic phase of virus maturation.
Zini
N
N
Institute of Normal and Pathologic Cytomorphology, C.N.R., c/o I.O.R., Bologna, Italy.
Battista
M C
MC
Santi
S
S
Riccio
M
M
Bergamini
G
G
Landini
M P
MP
Maraldi
N M
NM
D002460:Cell Line; D003587:Cytomegalovirus / Q000737:chemistry* / Q000648:ultrastructure; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D010750:Phosphoproteins / Q000032:analysis / Q000096:biosynthesis; D014764:Viral Proteins / Q000032:analysis* / Q000096:biosynthesis; D015678:Viral Structural Proteins / Q000032:analysis* / Q000096:biosynthesis
D010750:Phosphoproteins; C087088:UL25 protein, Cytomegalovirus; D014764:Viral Proteins; D015678:Viral Structural Proteins