Apoptosis signaling in lymphocytes.
Lymphocyte apoptosis is essential for proper function of the immune system. Among other functions, it is responsible for the homeostasis of immune cells and plays a key role in the elimination of autoreactive lymphocytes. Recently, progress has been made in the identification of genes that regulate apoptosis. Studies characterizing the basic apoptosis signaling machinery have begun to reveal the molecular control of processes that modulate lymphocyte apoptosis.
Scaffidi
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Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852-1727, USA.
Kirchhoff
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Krammer
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Peter
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ME
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology*; D008954:Models, Biological; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D019014:fas Receptor / Q000378:metabolism
D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor