title: [Molecular structure of renin-angiotensin-aldosterone system].
abstract: The application of novel investigative techniques has demonstrated that the RAA system is one of the major regulators of blood pressure and fluid and electrolyte homeostasis. There is evidence that local RAA systems exist. In this paper we have presented molecular bases of RAA system structure-genomic analysis, tissue distribution, regulation and pharmacological implications. We have payed attention to genomic linkage of the angiotensynogen gene with predisposition to the essential hypertension at human and to possibility of hormones influence at expression this gene.
authors.affiliation: I Oddziału Chorób Wewnetrznych Szpitala Rejonowego w Zabrzu.
authors.forename: M
authors.initials: M
authors.lastname: Zelechowski
authors.forename: W
authors.initials: W
authors.lastname: Pokrzywnicki
mesh_terms: D000450:Aldosterone / Q000235:genetics* / Q000378:metabolism*; D000804:Angiotensin II / Q000235:genetics* / Q000378:metabolism*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D004573:Electrolytes / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D012083:Renin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004573:Electrolytes; D012333:RNA, Messenger; D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin
vernacular_title: Molekularna budowa układu renina-angiotensyna-aldosteron.