Constrictive bronchiolitis obliterans and paraneoplastic pemphigus.
Constrictive bronchiolitis obliterans is rare, and the pathogenesis of the disease often remains unknown. This study reports on the case of a 38 yr-old female with constrictive bronchiolitis obliterans and paraneoplastic pemphigus associated with malignant lymphoma. The patient developed progressive obstructive lung disease. The chest radiograph showed almost normal lungs. Paraneoplastic pemphigus is a newly described syndrome in which patients have autoantibodies binding to some epithelia, including in the respiratory tract. The disease develops in association with non-Hodgkin's lymphomas or other malignant neoplasms. The case presented here suggests that constrictive bronchiolitis obliterans associated with paraneoplastic pemphigus may be one of the facets of autoimmune responses in this context.
Hasegawa
Y
Y
First Dept of Internal Medicine, Nagoya University School of Medicine, Japan.
Shimokata
K
K
Ichiyama
S
S
Saito
H
H
D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D016399:Lymphoma, T-Cell / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000276:immunology; D010392:Pemphigus / Q000209:etiology* / Q000276:immunology
D001323:Autoantibodies