Effect of 5-hydroxytryptamine infusion on microcirculation in the rabbit masseter muscle measured by laser-Doppler flowmetry.
The aim was to test the hypothesis that 5-hydroxytryptamine (5-HT) influences the microcirculation of the masseter muscle. Rabbit masseters were infused with increasing concentrations of 5-HT (10(-9)-10(-5) M) on the experimental side and with saline on the control side. The effect on microcirculatory blood flow was measured by laser-Doppler flowmetry. The intramuscular temperature was recorded to monitor the influence of tissue temperature. 5-HT infusion resulted in a statistically significant decrease in blood flow at the lowest concentration (10(-9) M) (median; -11.2%: Wilcoxon signed-rank test; p<0.05). At concentrations greater than 10(-9) M, there was no significant change in blood flow. This study shows a decrease of microcirculatory blood flow in the rabbit masseter following 5-HT infusion (10(-9) M).
Kurita
H
H
Department of Clinical Oral Physiology, Faculty of Dentistry, Karolinska Institutet, Huddinge, Sweden. hkurita@hsp.md.shinshu-u.ac.jp
Ernberg
M
M
Tominaga
K
K
Alstergren
P
P
Kopp
S
S
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005110:Extracellular Space; D007260:Infusion Pumps; D007273:Injections, Intramuscular / Q000295:instrumentation; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation; D008297:Male; D008406:Masseter Muscle / Q000098:blood supply* / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*; D012965:Sodium Chloride
D012701:Serotonin; D012965:Sodium Chloride