Pharmacokinetics of the 8-methoxyquinolone, moxifloxacin: tissue distribution in male rats.
BAY 12-8039 (moxifloxacin-HCl) and 14C-labelled BAY 12-8039 were administered to male rats as single i.v. and oral doses of 4.6 and 5.0 mg/kg bodyweight respectively. The distribution of substance-associated radioactivity in the body was investigated by whole-body autoradiography. The concentrations of the unchanged compound in plasma, skin suction blister fluid and lung tissue were determined by HPLC. Whole-body autoradiography revealed distinctly higher concentrations of radioactivity in the gastrointestinal tract, urinary bladder and in most organs and tissues (e.g. kidneys, liver, spleen, lungs, various glands, cartilaginous tissues and in melanin-containing structures located in the eye, meninges and hair follicles of pigmented skin) than in blood. Radioactivity crossed the blood-brain barrier only to a small extent. The results show a high tissue affinity and a rapid and homogeneous distribution of radioactivity from blood to organs or tissues. No relevant difference in the distribution of radioactivity was found following i.v. and oral administration. After i.v. and oral dosing similar concentrations of the unchanged compound were determined in skin suction blister fluid and plasma. The concentrations of the unchanged compound in lung tissue were about three times higher than those in plasma following both i.v. and oral administration. The concentration-time courses for moxifloxacin in plasma and lung tissue were parallel.
Siefert
H M
HM
Bayer AG, Pharma Research Center, Wuppertal, Germany. hans-martin.siefert.hs@bayer-ag.de
Kohlsdorfer
C
C
Steinke
W
W
Witt
A
A
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001345:Autoradiography; D001372:Aza Compounds; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid; D024841:Fluoroquinolones; D008297:Male; D000077266:Moxifloxacin; D011804:Quinolines; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D001372:Aza Compounds; D002250:Carbon Radioisotopes; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin