title: Description of a possible clonal expansion of Plasmodium vivax in Manaus-Amazonas-Brazil.
abstract: Atypical P. vivax cases reported in Manaus municipality led us to detect a genetic isolate of P. vivax. Variable regions of SSUrRNA were examined from the initial time of infection and in the two recrudescences/relapses from a patient exhibiting chloroquine and primaquine resistance. A unique isolate, found at all stages of infection, suggests the presence of a clonal expansion.
authors.affiliation: Fundação de Medicina Tropical do Amazonas da Universidade do Amazonas, Brasília.
authors.forename: M dos G
authors.initials: Mdos G
authors.lastname: Alecrim
authors.forename: W D
authors.initials: WD
authors.lastname: Alecrim
authors.forename: V
authors.initials: V
authors.lastname: Macêdo
authors.forename: C T
authors.initials: CT
authors.lastname: Korves
authors.forename: D R
authors.initials: DR
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Sullivan
authors.forename: T F
authors.initials: TF
authors.lastname: McCutchan
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001938:Brazil / Q000453:epidemiology; D002738:Chloroquine / Q000627:therapeutic use; D002999:Clone Cells; D004351:Drug Resistance; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D010966:Plasmodium vivax / Q000235:genetics*; D011319:Primaquine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011319:Primaquine