Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A).
Most of disproportionate infants born small for gestational age (SGA) have an history of placental dysfunction with no explained cause. We report a case of an unexplained SGA infant with placental infarctions and thrombosis. Maternal thrombophilic disorder tests revealed that the patient was heterozygous for the A20210 prothrombin gene variant a newly identified thrombotic risk factor. It may be suggest that prothrombin gene variant, as factor V Leiden, could be a genetic risk factor for placental insufficiency.
Verspyck
E
E
Department of Obstetrics and Gynecology, Rouen University Hospital, France. eric.verspyck@chu-rouen.fr
Le Cam-Duchez
V
V
Gravier
A
A
Descargues
G
G
Marpeau
L
L
Borg
J Y
JY
D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007238:Infarction; D010920:Placenta / Q000098:blood supply; D010927:Placental Insufficiency / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis
D011516:Prothrombin