[Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers'].
Individuals with one first-degree relative with colorectal cancer diagnosed before age 45 years and those with two first-degree relatives with colorectal cancer run a significantly increased risk (relative risk: 4-6) of developing colorectal cancer. Based on calculation of the mortality due to colorectal cancer for the age group 50-70 years (which is higher than the mortality due to breast cancer) surveillance may be justified, e.g. by colonoscopy at 5-year intervals from the age of 45-50. The total number of people in the Netherlands in this high risk group is estimated at 10,000. The authors conclude that prospective studies are needed to assess the cost-effectiveness of such a programme.
Vasen
H F
HF
Stichting Opsporing Erfelijke Tumoren, p/a Leids Universitair Medisch Centrum, Leiden. nfdht@xs4all.nl
Nagengast
F M
FM
Griffioen
G
G
Kleibeuker
J H
JH
Menko
F H
FH
Taal
B G
BG
D000368:Aged; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012306:Risk
Periodiek colonoscopisch onderzoek bij personen met een belaste familieanamnese voor colorectaal carcinoom.