title: In vitro and in vivo activities of tea catechins against Helicobacter pylori.
abstract: The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 microg/ml). It had bactericidal activity at pH 7 but not at pH </=5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.
authors.affiliation: Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585, Japan. kmabe@med.id.yamagata-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Mabe
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: I
authors.initials: I
authors.lastname: Oguni
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects*; D008297:Male; D008826:Microbial Sensitivity Tests; D013662:Tea
chemical_list: D013662:Tea; D002392:Catechin