The roles of RNA-binding proteins in spermatogenesis and male infertility.
RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.
Venables
J P
JP
Department of Biochemistry University of Leicester University Road, Leicester, LE1 7RH, UK. J.Venables@hgu.mrc.ac.uk
Eperon
I
I
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D009687:Nuclear Proteins / Q000502:physiology; D016601:RNA-Binding Proteins / Q000502:physiology*; D013091:Spermatogenesis / Q000502:physiology*
D009687:Nuclear Proteins; D016601:RNA-Binding Proteins