In-vitro antimicrobial activity of a carbapenem, MK-0826 (L-749,345) and provisional interpretive criteria for disc tests.
The in-vitro activity of MK-0826, a new oral carbapenem, was compared with that of imipenem by broth microdilution susceptibility tests against 545 bacterial isolates. MK-0826 had significantly greater activity against Enterobacteriaceae and poorer activity against Pseudomonas aeruginosa and many gram-positive species. MK-0826 disc diffusion tests were also performed according to the NCCLS procedure and tentative interpretive criteria were determined for possible susceptible MIC breakpoints of < or = 4.0 and < or = 2.0 mg/L.
Fuchs
P C
PC
The Clinical Microbiology Institute, Wilsonville, OR 97070, USA.
Barry
A L
AL
Brown
S D
SD
D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods
D015780:Carbapenems; C108047:L 749345; D015378:Imipenem