Hyaluronate, tetrachlorodecaoxide, and galactolipid prevent adhesions after implantation of Gore-Tex and dura mater into the abdominal wall in rats.
Gore-Tex (GT) and dura mater (DM) are used as prosthetic materials for the closure of the abdominal wall defects, however, they create intra-abdominal adhesions. This study addresses the question of which substances can reduce these adhesions. In rats, Gore-Tex and DM were placed on the inner abdominal wall. Two weeks later the animals were killed; the anterior abdominal wall was excised and photographed. The photographs were digitized and the surface area covered by adhesion was measured by computer analysis. In animals where DM or GT was implanted without the addition of an anti-adhesive substance, 45% of the DM and 34% of the GT surface was covered by adhesions. When hyaluronate (HA), tetrachlorodecaoxide, or galactolipid was applied to the bowel intra-operatively, adhesions were found on only 14%, 11% or 8% of the GT surface. For DM, only HA was effective, and reduced adhesions to 9% and 10%, respectively. Plasmin, taurolidine, and streptokinase-streptodomase were ineffective in preventing adhesions in both DM and GT.
Schier
F
F
Department of Pediatric Surgery, University Medical Center Jena, Bachstrasse, 18, D-07740 Jena, Germany.
Danzer
E
E
Bondartschuk
M
M
D000009:Abdominal Muscles / Q000601:surgery*; D000818:Animals; D002713:Chlorine / Q000627:therapeutic use*; D004388:Dura Mater; D038983:Galactolipids; D006017:Glycolipids / Q000627:therapeutic use*; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D020007:Implants, Experimental; D008297:Male; D010087:Oxides / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene; D051381:Rats; D000267:Tissue Adhesions / Q000517:prevention & control*
D038983:Galactolipids; D006017:Glycolipids; D010087:Oxides; D002713:Chlorine; D011138:Polytetrafluoroethylene; D006820:Hyaluronic Acid; C041955:tetrachlorodecaoxide