title: Pelvic malignant mixed mesodermal tumor of uncertain origin: a case report.
abstract: Extra-uterine, and especially extragenital, malignant mixed mesodermal tumors (MMMT) are very rare. A large intrapelvic tumor resected from a 56-year-old woman was investigated with morphological and immunohistochemical methods. A large, soft and fragile tumor was located in the pelvic space. The tumor showed high cellularity and was biphasic; it consisted of an admixture of adenocarcinoma and various kinds of sarcomas. The latter were comprised of high-grade endometrial stromal sarcoma, pleomorphic sarcoma, and chondrosarcoma. The pleomorphic sarcoma showed a storiform pattern. The periodic acid-Schiff-positive eosinophilic hyaline droplets and globules in multinucleated giant cells revealed a typical ring-like or peripheral staining for alpha-1-antitrypsin and alpha-1 antichymotrypsin. We considered this case to be pelvic MMMT of uncertain origin, heterologous type.
authors.affiliation: Department of Obstetrics and Gynecology, Mito Saiseikai General Hospital, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: H
authors.initials: H
authors.lastname: Hakozaki
authors.forename: S
authors.initials: S
authors.lastname: Koyamatsu
authors.forename: T
authors.initials: T
authors.lastname: Tobita
authors.forename: M
authors.initials: M
authors.lastname: Okane
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Mukai
authors.forename: N
authors.initials: N
authors.lastname: Mori
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018199:Mixed Tumor, Mesodermal / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D010386:Pelvic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed