[Concentric changes in the visual field associated with GABA-mimetic antiepileptic agents].
Bilateral visual field constriction has been recently reported in patients treated with vigabatrin. It has been considered that vigabatrin, a GABA agonist antiepileptic drug, was specifically responsible for this visual field defect. We present four observations sharing the same characteristics of chronic tunnel vision. Three patients had had vigabatrin but the fourth one received other antiepileptic drugs, progabide, an agonist of post-synaptic GABA receptors, and phenobarbital which interferes with GABA-A receptors. It is thus possible to hypothesize a retinal toxicity triggered by chronically increased GABA transmission. If this is confirmed, an accurate incidence of symptomatic and asymptomatic visual field constriction with GABA-mimetic drugs should be established, as well as the patients' profiles which are more at risk. Patients currently under this type of treatment should be checked by both manual and automatic perimetry every six months to one year.
Nordmann
J P
JP
Service d'Ophtalmologie, Hôpital Tenon, Paris.
Baulac
M
M
Van Egroo
C
C
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D018757:GABA Modulators / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000009:adverse effects*; D020888:Vigabatrin; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives*
D000927:Anticonvulsants; D018757:GABA Modulators; C017985:progabide; D005680:gamma-Aminobutyric Acid; D020888:Vigabatrin; D010634:Phenobarbital
Altérations concentriques du champ visuel liées aux antiépileptiques GABA mimétiques.