title: Impact of localized radiotherapy on blood immune cells counts and function in humans.
abstract: Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT.
authors.affiliation: Department of Radiation Oncology, Eberhard Karls University Tübingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Belka
authors.forename: H
authors.initials: H
authors.lastname: Ottinger
authors.forename: E
authors.initials: E
authors.lastname: Kreuzfelder
authors.forename: M
authors.initials: M
authors.lastname: Weinmann
authors.forename: M
authors.initials: M
authors.lastname: Lindemann
authors.forename: A
authors.initials: A
authors.lastname: Lepple-Wienhues
authors.forename: W
authors.initials: W
authors.lastname: Budach
authors.forename: H
authors.initials: H
authors.lastname: Grosse-Wilde
authors.forename: M
authors.initials: M
authors.lastname: Bamberg
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology / Q000528:radiation effects; D018655:Lymphocyte Count / Q000528:radiation effects; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011446:Prospective Studies; D018239:Seminoma / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D013736:Testicular Neoplasms / Q000276:immunology / Q000532:radiotherapy* / Q000601:surgery