title: [Antimutagenic effects of beta-carotene from Dunaliella salina].
abstract: OBJECTIVE
  To study the genotoxic and antimutagenic efficts of beta-carotene from Dunaliella salina (beta-CDS).
  
  
  METHODS
  The in vitro micronucleus and chromosomal aberration tests in hunman lymphocytes were adopted. The effect of beta-CDS on mutagensis induced by gamma-rays and mitomycin (Mit) was studied.
  
  
  RESULTS
  beta-CDS (1-30 mg.L-1) had no genotoxicity, but inhibited spontaneous and gamma-ray-induced micronucleus fromation and Mit-induced chromosomal aberrations in human lymphocytes in vitro. The genotoxic action of synthetic beta-carotene (S beta C) was suppressed, the antimutagenic effects were heightened when S beta C and beta-carotene oil (beta CO, one of the beta-CDS compositions) were mixed in proportion as 80:27.5.
  
  
  CONCLUSIONS
  beta-CDS is an antimutagenic agent.
authors.affiliation: Jiangsu Institute of Cancer Research, Nanjing, China.
authors.forename: G J
authors.initials: GJ
authors.lastname: Ma
authors.forename: K X
authors.initials: KX
authors.lastname: Xue
authors.forename: J Z
authors.initials: JZ
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Yuan
authors.forename: H L
authors.initials: HL
authors.lastname: Qin
mesh_terms: D000328:Adult; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000460:Chlorophyta / Q000737:chemistry; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D019207:beta Carotene / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D016587:Antimutagenic Agents; D019207:beta Carotene