The non-surgical treatments of hepatocellular carcinomas in a patient with severe hemophilia A.
We recently treated a patient with multiple hepatocellular carcinomas (HCC) who had severe hemophilia A and thrombocytopenia secondary to cirrhosis. He was not a candidate for surgery because of his liver failure. Transcatheter arterial chemoembolization and percutaneous ethanol injection therapy were successfully performed without complications by maintaining factor VIII levels above 40%. We believe that the non-surgical treatment of HCC can be performed safely in patients with coagulation disorders, by the appropriate administration of coagulation factors, despite thrombocytopenia and/or elongation of the prothrombin time from cirrhosis.
Toyoda
H
H
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Fukuda
Y
Y
Nakano
I
I
Katano
Y
Y
Ebata
M
M
Morita
K
K
Nagano
K
K
Yokozaki
S
S
Takeuchi
M
M
Hayashi
K
K
Hayakawa
T
T
Takamatsu
J
J
D000328:Adult; D000792:Angiography; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000150:complications / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D003131:Combined Modality Therapy; D015251:Epirubicin / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D005169:Factor VIII / Q000008:administration & dosage / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000098:blood supply / Q000150:complications / Q000628:therapy*; D008297:Male; D014057:Tomography, X-Ray Computed
D000431:Ethanol; D015251:Epirubicin; D005169:Factor VIII