Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
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Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School. Charlestown, MA 02129, USA.
Heitzler
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Ezekowitz
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White
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D000818:Animals; D017209:Apoptosis; D018955:CD36 Antigens / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000502:physiology; D004926:Escherichia coli / Q000276:immunology; D017353:Gene Deletion; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D016623:Ion Pumps; D008264:Macrophages / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D010587:Phagocytosis; D010641:Phenotype; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D051116:Receptors, Scavenger; D013211:Staphylococcus aureus / Q000276:immunology
D018955:CD36 Antigens; D002352:Carrier Proteins; D029721:Drosophila Proteins; D016623:Ion Pumps; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; C099526:crq protein, Drosophila; C094756:mvl protein, Drosophila