[Practical considerations respecting the clinical use of serum cystatin C as a marker of glomerular filtration].
A curvilinear relationship of potential type was observed between serum concentrations of cystatine C and creatinine in 187 patients attended at our Nephrology Department. This relationship became linear when considering the reverse values, but the estimation error was much higher than what is clinically acceptable, which prevents the interconversion of values. In 78 critical patients, in whom an antibiotic therapeutic monitoring was being carried out, serum creatinine concentrations in the reference range were observed to be associated with pathologic concentrations of cystatine C. In 22 regularly hemodialysed patients, using Hemophan or Cuprophan membranes, increments of approximately 5% for cystatine C and beta 2-microglobuline in post-dialysis samples were observed. The chronic administration of inducer antiepileptic drugs, capable of modifying the concentration of different plasmatic proteins and reducing the serum concentration of creatinine, does not seem to limit the applicability of cystatine C as marker for glomerular filtration. The routine measurement of cystatine C seems to be warranted for estimating the glomerular filtration rate in patients in whom creatinine synthesis might be impaired.
Riveiro Cruz
A
A
Laboratorio Central, Hospital General de Galicio-Clínico Universitario, Santiago de Compostela, A Coruña.
Represa Veiga
S
S
Cordal Martínez
T
T
Louro Carballeira
M O
MO
Tutor Valcarce
J C
JC
D000328:Adult; D015415:Biomarkers / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D003955:Diagnostic Tests, Routine / Q000706:statistics & numerical data; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007118:Immunoassay / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000706:statistics & numerical data; D016011:Normal Distribution; D006435:Renal Dialysis
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins
Algunas consideraciones prácticas con respecto al uso clínico de la cistatina C sérica como marcador de filtración glomerular.