Ulcerative colitis complicated by dysplasia-adenoma-carcinoma in a man with Bloom's syndrome.
Bloom's syndrome (BS) is a rare genetic disorder in which the major clinical feature is growth deficiency. The genome in BS somatic cells is unstable, and hypermutability explains many clinical features. Most notably, affected persons are at enormously increased risk of developing many types of cancers at different sites. It has been well known that ulcerative colitis (UC) is associated with the spectrum of epithelial changes signifying dysplasia and the progression to frank carcinoma. We report here a case of UC complicated by dysplasia-adenoma-carcinoma sequence in a 37-year-old man with BS.
Wang
J
J
Department of Pathology, Harbor-UCLA Medical Center, University of California Los Angeles, School of Medicine, Torrance 90509, USA.
German
J
J
Ashby
K
K
French
S W
SW
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000236:Adenoma / Q000150:complications* / Q000473:pathology; D000328:Adult; D001816:Bloom Syndrome / Q000150:complications*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011230:Precancerous Conditions / Q000150:complications* / Q000473:pathology