Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation.
The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.
Barr
T A
TA
Division of Molecular and Genetic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom.
Heath
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AW
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000942:Antigens, Bacterial; D019013:CD40 Antigens; D008070:Lipopolysaccharides