Hypotensive, hypoglycaemic and toxicological studies on the flavonol C-glycoside shamimin from Bombax ceiba.
Shamimin, a C-flavonol glucoside from Bombax ceiba leaves showed significant potency as a hypotensive agent at the doses of 15 mg/kg, 3 mg/kg, 1 mg/kg and significant hypoglycaemic activity at 500 mg/kg in Sprague-Dawley rats. Further studies revealed that it did not cause any mortality in mice at the dose of 1 g/kg but in rats 500 mg/kg is a lethal dose. Aqueous and methanolic extracts of Bombax ceiba leaves and one of its fractions were also subjected to pharmacological and toxicological screening.
Saleem
R
R
Dr. H. M. I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan.
Ahmad
M
M
Hussain
S A
SA
Qazi
A M
AM
Ahmad
S I
SI
Qazi
M H
MH
Ali
M
M
Faizi
S
S
Akhtar
S
S
Husnain
S N
SN
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D010944:Plants / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D005419:Flavonoids; D007004:Hypoglycemic Agents; C119820:shamimin; D005947:Glucose