A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex.
Two crystal structures of an IkappaB-NFkappaB complex have recently been determined. The structures show in detail how IkappaB controls the subcellular localization and activity of the eukaryotic transcription factor NFkappaB.
Cramer
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European Molecular Biology Laboratory (EMBL), Grenoble Outstation, c/o ILL, BP 156, F-38042 Grenoble Cedex 9, France.
Müller
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CW
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D020672:I-kappa B Proteins; D008954:Models, Biological; D008958:Models, Molecular; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary
D004268:DNA-Binding Proteins; D020672:I-kappa B Proteins; D016328:NF-kappa B; D000072000:NF-KappaB Inhibitor alpha