[Influence of fibrin glue on biliointestinal anastomotic scar formation].
Conventional suture technique in the reconstruction of the bile duct often result in anastomotic stenosis and eventual obstructive jaundice and biliary cirrhosis. To overcome the aforementioned drawbacks, fibrin glue (FG) was used instead in the biliointestinal anastomosis where indwelling stent was inserted to complete the experimental model. The experiment consisted of pathological study and ECVD evaluation of anastomotic specimens in order to follow up the whole process of anastomotic wound healing. The experimental studies dis-closed that FG promotes wound healing, limits scar formation, and accelerates scar softening and maturnation. FG plus 6-month indwelling stent can guarantee scar maturation. It is an effective method in the prevention of bile duct stricture.
Zhang
L
L
Department of Surgery, Ninth People's Hospital, Shanghai Second Medical University.
Zhou
L
L
Xue
Z
Z
D000713:Anastomosis, Roux-en-Y; D000818:Animals; D002921:Cicatrix / Q000517:prevention & control*; D003135:Common Bile Duct / Q000473:pathology* / Q000601:surgery*; D003251:Constriction, Pathologic / Q000517:prevention & control; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D007583:Jejunum / Q000601:surgery; D008297:Male; D014945:Wound Healing / Q000187:drug effects
D015718:Fibrin Tissue Adhesive