Synthesis of some new biologically active thiadiazolotriazinones--Part II.
4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condensed with an aromatic carboxylic acid, aryloxyacetic acid or anilinoacetic acid (2), to yield 7-substituted-3-phenyl/methyl-4H-1,3,4-thiadiazolo-[2,3-c]-1,2,4-+ ++triazin-4- ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial activities against S. aureus, E. coli, P. aeruginosa and G. bacillus.
Holla
B S
BS
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Mangalagangothri, India.
Sarojini
B K
BK
Shridhara
K
K
Antony
G
G
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D014227:Triazines