[Post-resuscitation neurosomatic deviations and the feasibility of their correction with a drug of metabolic action].
Circulation in white rat males was stopped for 10 minutes by ligation of the intrathoracic vascular bundle of the heart. Proxipin in a dose 10 or 20 mg/kg was injected i.p. after restoration of effective cardiac activity and the next 3 days. Proxipin improved resuscitation outcomes, relieved symptoms of CNS excitability 4-6 months after resuscitation, changed adaptation to stress agents, protected against risk-factors of atherogenesis. However, proxipin-induced inhibition of the motor activity suppressed the free-choice ability to find food.
Zarzhetskiĭ
Iu V
IuV
Mutuskina
E A
EA
Trubina
I E
IE
Pylova
S I
SI
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002036:Bundle of His / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D018755:GABA Agonists / Q000627:therapeutic use*; D008297:Male; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats; D012151:Resuscitation
D000975:Antioxidants; D018755:GABA Agonists; D011725:Pyridines
Postreanimatsionnye neĭrosomaticheskie otkloneniia i vozmozhnosti ikh korrektsii preparatom metabolicheskogo deĭstviia.