Poly(fumaric-co-sebacic anhydride). A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction.
The degradation of three poly(fumaric-co-sebacic anhydride) [P(FA:SA)] copolymers is examined in a composition of microspheres made by the hot melt encapsulation process. The emergence of low molecular weight oligomers occurs during degradation of the copolymer microspheres, as evidenced by a variety of characterization methods. Characterization was conducted to determine the extent of degradation of the polyanhydride microspheres using Fourier-transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and X-ray diffraction. It is demonstrated that degradation of P(FA:SA) is greatly accelerated at basic pH, yet there is little difference between degradation in neutral and acidic buffers. A good correlation exists between the results of each characterization method, which allows a better understanding of the degradation process and the resulting formation of low molecular weight oligomers in poly(fumaric-co-sebacic anhydride).
Santos
C A
CA
Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Box G-B393, Providence, RI 02912, USA.
Freedman
B D
BD
Leach
K J
KJ
Press
D L
DL
Scarpulla
M
M
Mathiowitz
E
E
D000812:Anhydrides / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids; D016503:Drug Delivery Systems; D005650:Fumarates / Q000737:chemistry*; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000812:Anhydrides; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D005650:Fumarates; D011108:Polymers; C032005:fumaric acid; C011107:sebacic acid