title: Comparison of liver resection for hepatocellular carcinoma in hepatitis B and hepatitis C-related cirrhotic patients.
abstract: OBJECTIVE
  The differences of liver resection for hepatocellular carcinoma (HCC) between hepatitis B and C-related cirrhotic liver remain unknown. This study compares the surgical results of HCC in hepatitis B and hepatitis C-related cirrhotic patients in an area endemic of hepatitis B.
  
  
  METHODS
  A retrospective comparison of the clinicopathological features and early and long-term results of 110 cirrhotic patients with seropositive hepatitis B surface antigen only (group B) and 55 patients with seropositive anti-hepatitis C antibody only (group C) was carried out.
  
  
  RESULTS
  Group C patients were older, had a lower serum alpha-fetoprotein level, greater indocyanine retention rate, and higher incidence of multicentric tumors. Tumor size was larger and there was a higher incidence of combined satellite nodules in group B patients. There were no significant differences in operative morbidity and mortality between the two groups. Group B patients had a slightly shorter disease-free interval (p = 0.07) but a better actuarial survival rate (p = 0.05) than group C patients.
  
  
  CONCLUSIONS
  The hepatitis status did not affect the operative risks in cirrhotic livers. However, after resection of HCC, poorer liver functional reserve in hepatitis C-related cirrhotic patients caused poorer actuarial survival rate when compared with hepatitis B-related cirrhotic patients.
authors.affiliation: Department of Surgery, Taichung Veterans General Hospital, Chung-Shan Medical College, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Wu
authors.forename: J S
authors.initials: JS
authors.lastname: Tang
authors.forename: M C
authors.initials: MC
authors.lastname: Lin
authors.forename: D C
authors.initials: DC
authors.lastname: Yeh
authors.forename: T J
authors.initials: TJ
authors.lastname: Liu
authors.forename: F K
authors.initials: FK
authors.lastname: P'eng
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D019694:Hepatitis B, Chronic / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D019698:Hepatitis C, Chronic / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate