title: Incidence of diarrhea among calves after strict closure and eradication of bovine viral diarrhea virus infection in a dairy herd.
abstract: OBJECTIVE
  To determine whether strict closure of a dairy herd and eradication of bovine viral diarrhea virus (BVDV) infection would decrease incidence of diarrhea in calves during the first 31 days after birth, whether specific risk factors were associated with incidence of diarrhea in calves, and whether diarrhea was associated with weight gain of the calves.
  
  
  METHODS
  2-year cohort study.
  
  
  METHODS
  448 calves.
  
  
  METHODS
  Calves were monitored from birth to 31 days of age. Fecal samples were tested for rotavirus, blood samples were tested for BVDV and antibodies to BVDV, and serum samples were tested for IgG concentration. Risk factors were evaluated by means of survival analysis.
  
  
  RESULTS
  Incidence of diarrhea in calves decreased significantly after strict closure of the herd and eradication of BVDV infection. Risk factors for diarrhea in calves interacted in a multifactorial way. Rotavirus infection and low serum IgG concentration increased the risk that calves would develop diarrhea. Calves that developed diarrhea gained significantly less weight than calves that did not develop diarrhea.
  
  
  CONCLUSIONS
  To control diarrhea among calves in a dairy herd, emphasis should be on maintaining a strictly closed herd free from BVDV infection. However, other measures, such as measures to prevent rotavirus infection and to ensure that calves receive an appropriate amount of colostrum after birth, should also be taken.
authors.affiliation: Department of Ruminant and Porcine Diseases, National Veterinary Institute, Uppsala, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: de Verdier Klingenberg
authors.forename: I
authors.initials: I
authors.lastname: Vågsholm
authors.forename: S
authors.initials: S
authors.lastname: Alenius
mesh_terms: D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control*; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000517:prevention & control; D015331:Cohort Studies; D003967:Diarrhea / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D008297:Male; D011790:Quarantine / Q000662:veterinary; D012307:Risk Factors
chemical_list: D007074:Immunoglobulin G