title: Enhanced treatment outcomes for cocaine-using methadone patients.
abstract: Cocaine dependent methadone patients were randomly assigned to 6 months of high intensity cognitive-behavioral therapy or low intensity therapy. A repeated measures ANOVA was conducted with patients stratified on severity of cocaine use at baseline. Both treatment groups showed significant and equivalent reductions in cocaine use during the post-treatment period. Completing either therapy and lower cocaine severity at baseline were associated with lower proportion of cocaine-positive urines across a 48-week post-treatment period. Examination of the treatment x cocaine severity interaction provided some evidence that high-severity patients improved more if exposed to high intensity treatment than to low intensity treatment. Positive outcomes for therapy completers relative to non-completers increased over time. The results are consistent with several clinical trials showing that: (1) participation in treatment is associated with reductions in cocaine use; and (2) the relationship between treatment intensity and outcome is not linear and may better be explained by an interaction between patient and treatment factors.
authors.affiliation: Institute for Treatment and Services Research, National Development and Research Institutes, Inc., New York, NY 10048, USA.
authors.forename: A
authors.initials: A
authors.lastname: Rosenblum
authors.forename: S
authors.initials: S
authors.lastname: Magura
authors.forename: M
authors.initials: M
authors.lastname: Palij
authors.forename: J
authors.initials: J
authors.lastname: Foote
authors.forename: L
authors.initials: L
authors.lastname: Handelsman
authors.forename: B
authors.initials: B
authors.lastname: Stimmel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D019970:Cocaine-Related Disorders / Q000191:economics / Q000534:rehabilitation* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009294:Narcotics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D009294:Narcotics; D008691:Methadone