title: Lead and calcium transport in human erythrocyte.
abstract: In this paper we report the lead (Pb) and calcium (Ca) uptake by erythrocyte ghosts. In both cases the transport was carried out by a passive transport system with two kinetic components (Michaelis-Menten and Hill). Pb and Ca were capable of inhibiting the transport of the other metal in a non-competitive way. Under hyperpolarization, the uptakes of Ca and Pb were enhanced and the Michaelis-Menten component prevailed. Both Ca and Pb uptakes were inhibited by N-ethyl-maleimide to the same extent. These results indicate that Pb and Ca share the same permeability pathway in human erythrocytes and that this transport system is electrogenic.
authors.affiliation: Department of Biochemistry, CINVESTAV-IPN, México City, México.
authors.forename: J V
authors.initials: JV
authors.lastname: Calderón-Salinas
authors.forename: M A
authors.initials: MA
authors.lastname: Quintanar-Escorcia
authors.forename: M T
authors.initials: MT
authors.lastname: González-Martínez
authors.forename: C E
authors.initials: CE
authors.lastname: Hernández-Luna
mesh_terms: D000328:Adult; D002118:Calcium / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005033:Ethylmaleimide / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D017136:Ion Transport / Q000187:drug effects; D007700:Kinetics; D007854:Lead / Q000378:metabolism*; D008297:Male
chemical_list: D007473:Ion Channels; D007854:Lead; D005033:Ethylmaleimide; D002118:Calcium