[The utility of rapid qualitative determination of troponin T, the MB fraction of creatine phosphokinase and myoglobin in acute ischemic coronary syndromes].
The objective of our study was to validate the diagnostic utility of cardiac troponine T in acute ischemic syndromes, and also in cases of difficult diagnosis. We analyzed its concordance and compare them with conventional enzymatic quantitative methods. We determined sensitivity, specificity, positive and negative predictive values and likelihood ratio. Kappa index was used to know the concordance grade between T troponin and the positive or negative results of the quantitative enzymatic curve. Stochastic significance was valued by Chi square of Mcnemar test. In seventy patients who arrived to the hospital with chest pain who were assigned to five different groups. The sensitivity in quantitative markers was higher than qualitative methods, however the specificity, likelihood ratio was lower. In the total group the concordance analysis between qualitative and quantitative markers was adequate, (kappa index 0.65 p < 0.05). This study suggest that the rapid bedside qualitative test by cardiac Troponin T is a good diagnostic marker compared with conventional quantitative markers to evaluate chest pain in acute ischemic syndromes.
Juárez Herrera
U
U
Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Lasses y Ojeda
L A
LA
Rosas Peralta
M
M
Luna Guerra
J
J
López Rodríguez
M C
MC
Chuquiure Valenzuela
E
E
Martínez Sánchez
C
C
González Pacheco
H
H
Jiménez
M G
MG
Reyes
P A
PA
Herrera
E L
EL
D000208:Acute Disease; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000032:analysis*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009211:Myoglobin / Q000032:analysis*; D019095:Point-of-Care Systems; D020107:Troponin T / Q000032:analysis*
D007527:Isoenzymes; D009211:Myoglobin; D020107:Troponin T; D003402:Creatine Kinase
Utilidad de la determinación cualitativa rápida de troponina-T, fracción MB de creatina fosfocinasa y mioglobina en los síndromes isquémicos coronarios agudos.