[Hypereosinophilic syndrome complicated by myelofibrosis].
Hypereosinophilic syndrome (HES) with myelofibrosis was diagnosed in a 36-year-old man on the basis of bone marrow biopsy findings and clinical features. Although the patient was treated with steroid (1 mg/kg), hydroxyurea, and immunosuppressive therapy, eosinophilia persisted. Patients with HES and myelofibrosis are usually unresponsive to antineoplastic agents and/or immunosuppressants. However, cyclosporin may be an effective alternative for such patients.
Okabe
S
S
First Department of Internal Medicine, Tokyo Medical University.
Yahata
N
N
Tauchi
T
T
Otawa
M
M
Iwase
O
O
Toyama
K
K
Ohyashiki
K
K
Serizawa
H
H
Ebihara
Y
Y
D000328:Adult; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications*