Biological and chemical characterization of the fraction with antiherpetic activity from Achyrocline flaccida.
The in vitro antiviral activity demonstrated by aqueous extract (AE) of Achyrocline flaccida on herpes simplex virus type-1 is exerted early during the viral replication, essentially during the viral adsorption to host cells. A bioguided purification process of the AE indicated that negatively charged polysaccharides were responsible for this antiviral activity.
García
G
G
Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
Cavallaro
L
L
Broussalis
A
A
Ferraro
G
G
Martino
V
V
Campos
R
R
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D014709:Vero Cells
D000998:Antiviral Agents; D010936:Plant Extracts