In vitro and in vivo activities of tea catechins against Helicobacter pylori.
The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 microg/ml). It had bactericidal activity at pH 7 but not at pH </=5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.
Mabe
K
K
Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata City, Yamagata 990-9585, Japan. kmabe@med.id.yamagata-u.ac.jp
Yamada
M
M
Oguni
I
I
Takahashi
T
T
D000818:Animals; D002392:Catechin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000187:drug effects*; D008297:Male; D008826:Microbial Sensitivity Tests; D013662:Tea
D013662:Tea; D002392:Catechin