[Incidence of TT virus infection in patients with non-A to G liver disease].
The sera of patients with liver disease associated with non-A to G hepatitis were examined for the presence of TTV DNA. These patients included 18 cases with AH, 8 cases with CH, 6 cases with LC, 4 cases with HCC, and 36 cases with blood donors. The detection of TTV DNA was performed as described by Nishizawa et al. TTV DNA was detected in 60.0%, 62.5%, 66%, 50%, 28% of the patients with AH, CH, LC and HCC, respectively. Among the patients with AH, the aminotransferases and total bilirubin values were lower in the TTV DNA-positive than -negative patients. Among the patients with chronic liver disease, however, there were no differences in the blood chemistry results between the TTV DNA-positive and -negative patients. The histological study of the liver tissues from a TTV positive patient with CH showed no evidence of necro-inflammatory reaction, although there was evidence of irregular regeneration in the TTV DNA-positive a patient. These results suggest that TTV infection may modify the pathological condition of the liver disease.
Arakawa
Y
Y
Third Department of Internal Medicine, Nihon University School of Medicine.
Shioda
A
A
Moriyama
M
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D004266:DNA Virus Infections / Q000150:complications / Q000453:epidemiology*; D004267:DNA Viruses; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D004279:DNA, Viral