title: [Pseudallescheria boydii osteoarthritis in a patient with acute lymphoblastic leukemia: a case report].
abstract: BACKGROUND
  The outcome of neutropenic patients with Pseudallescheria boydii infection is poor.
  
  
  METHODS
  We report the first case of Pseudallescheria boydii hip arthritis in a patient treated for acute lymphoblastic leukemia. In vitro susceptibility testing showed that the strain was resistant to amphotericin B, fluorocytosine and nystatin, but susceptible to itraconazole. The patient received oral itraconazole (600 mg/day) and clinical symptoms initially resolved. Two months later, after a course of chemotherapy and high-dose steroids while receiving oral itraconazole treatment, the patient developed fever, skin lesions and disseminated lung infiltrates due to Pseudallescheria boydii and finally died.
  
  
  CONCLUSIONS
  This case illustrates the severity of fungal infections due to Pseudallescheria boydii despite a presumably well-conducted antifungal therapy.
authors.affiliation: Service d'hématologie clinique, Hôtel-Dieu, CHU, Nantes, France.
authors.forename: S L
authors.initials: SL
authors.lastname: Le Gouill
authors.forename: N
authors.initials: N
authors.lastname: Morineau
authors.forename: M
authors.initials: M
authors.lastname: Miégeville
authors.forename: N
authors.initials: N
authors.lastname: Milpied
authors.forename: J L
authors.initials: JL
authors.lastname: Harousseau
authors.forename: P
authors.initials: P
authors.lastname: Moreau
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D001203:Ascomycota / Q000145:classification / Q000187:drug effects; D017809:Fatal Outcome; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009181:Mycoses / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D011859:Radiography; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole
vernacular_title: Ostéoarthrite à Pseudallescheria boydii chez un patient porteur de leucémie aiguë lymphoblastique: à propos d'un cas.