title: The use of gelatin-resorcin-formalin glue in acute aortic dissection type A.
abstract: OBJECTIVE
  The Gelatin-resorcin-formalin (GRF) glue is widely used in the surgical treatment of dissecting aneurysms. This paper is focused on our experience with the GRF glue in cases, operated for acute aortic dissection type A.
  
  
  METHODS
  Between September 1990 and December 1997, 164 patients were operated on for acute aortic dissection type A. In 148 patients GRF was used to reinforce the dissected layers proximal (n = 106) or distal (n = 144) of the grafted aortic segment. An intervention at the aortic valve was necessary in 93 instances. In 111 patients, an open distal anastomosis for replacement of the proximal aortic arch was performed. Thirty-seven additional patients underwent subtotal or total aortic arch replacement.
  
  
  RESULTS
  Early postoperative mortality was 26.2% (43/164 patients). Another 16 patients died late postoperatively. Actuarial survival rates are 69.9% at 1 year, 62.5% at 3 years, 59.4% at 5 years and 56.1% at 7 years, post-operatively. Twenty-two reoperations were performed in 20 patients (16.5%). Nine of these patients had developed complications in aortic segments that underwent reconstruction by use of GRF during the primary intervention. Aortic root redissection was found in 7/9 patients intraoperatively, whereas 1/9 patients presented with a rupture near the distal graft to aortic anastomosis.
  
  
  CONCLUSIONS
  The introduction of GRF glue has greatly facilitated the reconstruction of dissected aortic wall layers adjacent to the vascular graft. However, the use of the adhesive for aortic root reconstruction in acute aortic dissection type A may bear a significant risk of late postoperative proximal aortic redissection. Complications associated with the GRF glue are likely to be due to the toxic effects of the formalin component. Therefore, care should be taken that the amount of formalin administered to the glue components remains as low as possible.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Surgical center, Hannover Medical School, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Fukunaga
authors.forename: M
authors.initials: M
authors.lastname: Karck
authors.forename: W
authors.initials: W
authors.lastname: Harringer
authors.forename: J
authors.initials: J
authors.lastname: Cremer
authors.forename: C
authors.initials: C
authors.lastname: Rhein
authors.forename: A
authors.initials: A
authors.lastname: Haverich
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000379:methods; D000784:Aortic Dissection / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D006348:Cardiac Surgical Procedures / Q000379:methods*; D015331:Cohort Studies; D018572:Disease-Free Survival; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D005557:Formaldehyde; D005780:Gelatin; D006801:Humans; D008297:Male; D008875:Middle Aged; D012118:Resorcinols; D015996:Survival Rate; D014014:Tissue Adhesives; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin