title: Cell cycle genes in chondrocyte proliferation and differentiation.
abstract: Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell cycle proteins play an important role in the coordination of chondrocyte proliferation and differentiation. Our current knowledge of the function and regulation of cell cycle proteins in endochondral ossification is summarized.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Calgary, AB, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Beier
authors.forename: T A
authors.initials: TA
authors.lastname: Leask
authors.forename: S
authors.initials: S
authors.lastname: Haque
authors.forename: C
authors.initials: C
authors.lastname: Chow
authors.forename: A C
authors.initials: AC
authors.lastname: Taylor
authors.forename: R J
authors.initials: RJ
authors.lastname: Lee
authors.forename: R G
authors.initials: RG
authors.lastname: Pestell
authors.forename: R T
authors.initials: RT
authors.lastname: Ballock
authors.forename: P
authors.initials: P
authors.lastname: LuValle
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D019902:Chondrocytes / Q000166:cytology*; D006801:Humans; D008322:Mammals
chemical_list: D018797:Cell Cycle Proteins