Finasteride in the treatment of men with frontal male pattern hair loss.
BACKGROUND
Finasteride, a specific inhibitor of type II 5alpha-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss.


OBJECTIVE
This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning.


METHODS
This was a 1-year, double-blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review.


RESULTS
There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated.


CONCLUSIONS
In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.
Leyden
J
J
University of Pennsylvania School of Medicine, Philadelphia, USA.
Dunlap
F
F
Miller
B
B
Winters
P
P
Lebwohl
M
M
Hecker
D
D
Kraus
S
S
Baldwin
H
H
Shalita
A
A
Draelos
Z
Z
Markou
M
M
Thiboutot
D
D
Rapaport
M
M
Kang
S
S
Kelly
T
T
Pariser
D
D
Webster
G
G
Hordinsky
M
M
Rietschel
R
R
Katz
H I
HI
Terranella
L
L
Best
S
S
Round
E
E
Waldstreicher
J
J
D058891:5-alpha Reductase Inhibitors; D000328:Adult; D000505:Alopecia / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D018120:Finasteride / Q000009:adverse effects / Q000627:therapeutic use*; D006197:Hair / Q000254:growth & development; D006801:Humans; D008297:Male; D017060:Patient Satisfaction
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D018120:Finasteride