title: Measurement of airway resistance using the interrupter technique in preschool children in the ambulatory setting.
abstract: This study describes the feasibility, repeatability, and interrater reliability of the measurement of airway resistance by the interrupter technique (Rint) in children 2-5 yrs of age, and examines whether reversibility to bronchodilator can be demonstrated in wheezy children. The mean of six Rint values was taken as a measurement. If subjects could complete one measurement and then a second 15 min after bronchodilator, baseline testing and reversibility testing were considered feasible. To measure repeatability, two measurements 30 s apart and measurements before and 15 min after placebo bronchodilator were compared. Measurements by two testers were compared for interrater reliability. Change in Rint in wheezy children was measured after bronchodilator. Fifty-six per cent of 2-3-yr-olds (n=79), 81% of 3-4-yr-olds (n=104) and 95% of 4-5-yr-olds (n=88) completed baseline testing, and 53%, 71% and 91% completed reversibility testing. Baseline measurements were 0.47-2.56 kPa x L(-1) x s. Repeatabilities (2 SD of the mean differences between measurements) at 30 s in the three age bands were 0.21, 0.17 and 0.15 kPa x L(-1) x s and 0.19 kPa x L(-1) x s after placebo. Using 0.21 kPa x L(-1) x s as the threshold for reversibility, reversibility was demonstrated in most wheezy children. Interrater reliability was 0.15 kPa x L(-1) x s. Preschool children can undertake measurements of airway resistance by the interrupter technique in ambulatory settings and reversibility to bronchodilator in wheezy children can be demonstrated. This technique promises to be a useful clinical and research tool.
authors.affiliation: Queen Elizabeth Children's Service, Royal London Hospital, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Bridge
authors.forename: S
authors.initials: S
authors.lastname: Ranganathan
authors.forename: S A
authors.initials: SA
authors.lastname: McKenzie
mesh_terms: D000403:Airway Resistance; D001249:Asthma / Q000175:diagnosis*; D001993:Bronchodilator Agents; D002675:Child, Preschool; D005240:Feasibility Studies; D006801:Humans; D015588:Observer Variation; D010044:Outpatient Clinics, Hospital; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D012135:Respiratory Sounds / Q000175:diagnosis
chemical_list: D001993:Bronchodilator Agents