title: [Remodelling of the radial artery graft 5 years after aortocoronary bypass intervention].
abstract: BACKGROUND
  The radial artery (RA) is being employed as coronary artery bypass graft with good results, but when it is proximally anastomosed to the ascending aorta, undergoes substantial hemodynamic changes which could lead to significant graft intimal hyperplasia. The aim of this study was to investigate the evolution of RA graft morphology over time.
  
  
  METHODS
  We studied 20 patients with a perfectly patent RA graft at both 1 and 5 year angiography after coronary artery bypass graft.
  
  
  RESULTS
  Both RA graft and grafted coronary artery diameters, assessed by quantitative coronary angiography, significantly increased at 5 years, in comparison to 1 year angiography (2.08 +/- 0.45 vs 2.54 +/- 0.53 mm, +22%, p < 0.001 and 1.92 +/- 0.47 vs 2.18 +/- 0.41 mm, +13.3%, p < 0.001, respectively).
  
  
  CONCLUSIONS
  Hemodynamic changes following RA employment for coronary artery bypass graft stimulate a remodeling of RA graft itself and of the grafted coronary arteries. The progressive increase of diameters observed in RA grafts strongly argues against the development of flow-limiting graft intimal hyperplasia when RA is proximally anastomosed to the ascending aorta. Moreover, grafted coronary artery dilation suggests that hemorrheologic changes following coronary artery bypass graft could play a major role in the development of RA remodeling over time.
authors.affiliation: Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Roma.
authors.forename: A
authors.initials: A
authors.lastname: Lupi
authors.forename: C
authors.initials: C
authors.lastname: Trani
authors.forename: M
authors.initials: M
authors.lastname: Gaudino
authors.forename: C
authors.initials: C
authors.lastname: Canosa
authors.forename: G
authors.initials: G
authors.lastname: Di Sciascio
authors.forename: V
authors.initials: V
authors.lastname: Ramazzotti
authors.forename: F
authors.initials: F
authors.lastname: Alessandrini
authors.forename: M A
authors.initials: MA
authors.lastname: Mazzari
authors.forename: G
authors.initials: G
authors.lastname: Schiavoni
authors.forename: G
authors.initials: G
authors.lastname: Possati
mesh_terms: D000704:Analysis of Variance; D015331:Cohort Studies; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017534:Radial Artery / Q000473:pathology / Q000637:transplantation*; D017539:Tunica Intima / Q000473:pathology*
vernacular_title: Rimodellamento dei graft in arteria radiale a cinque anni dall'intervento di bypass aortocoronarico.