title: Signal intensities in FLASH-EPI-hybrid sequences.
abstract: Theoretical considerations on the signal-to-noise ratio (SNR) in FLASH-EPI-Hybrid imaging were published previously. The purpose of this work was to investigate in vivo the signal intensities in Hybrid images as a function of sequence specific parameters. In detail, the SNR as a function of the number of echoes m per RF excitation, the excitation flip angle alpha, and the dependence on the tissue relaxation times T1 and T2* were studied. In eight healthy subjects brain and abdominal Hybrid images were acquired where m and alpha were changed independently. Signal intensities in human brain, liver, and kidney were evaluated for each Hybrid experiment. Additionally, T1 and T2* values of these tissue types were quantified to allow for a comparison with the theory. An excellent agreement between calculated and measured signal behavior was found. The theory was therefore validated in vivo and can thus be used to optimize the signal-to-noise in Hybrid experiments.
authors.affiliation: Physikalisches Institut, EP5, Universität Würzburg, Würzburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hillenbrand
authors.forename: R
authors.initials: R
authors.lastname: Deichmann
authors.forename: D
authors.initials: D
authors.lastname: Hahn
authors.forename: A
authors.initials: A
authors.lastname: Haase
mesh_terms: D001921:Brain / Q000033:anatomy & histology; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology