title: [Warning signs preceding the development of septic shock in patients with neutropenia treated for hematologic malignancies].
abstract: BACKGROUND
  In patients with haematological malignities infectious complications take a very rapid course, and in particular during the period of neutropenia, they are not necessarily manifested by a clear symptomatology. Frequently they may be manifested only by an elevated temperature and general deterioration of the condition. The onset of shock then can be rapid and surprising. The objective of the work was to identify clinical and laboratory signs warning against the possible development of septic shock.
  
  
  RESULTS
  The investigation comprised a total of 38 patients hospitalised due to infectious complications at the intensive care unit because of general deterioration of the condition. 18 developed septic shock (group S), the remaining 20 (group N) achieved during hospitalisation at the ICU a stabilised condition. In both groups the laboratory values and clinical condition were followed up for 2-3 days prior to deterioration of the condition. Risk factors for development of septic shock in the group of investigated patients were: unusual weakness, heart rate above 95/min. beyond the temperature peak, hypoalbuminaemia, mucositis, hypokalaemia, presence of a central venous catheter and administration of parenteral nutrition.
authors.affiliation: II. interní klinika FNsP, Brno-Bohunice.
authors.forename: H
authors.initials: H
authors.lastname: Kubesová
authors.forename: M
authors.initials: M
authors.lastname: Penka
authors.forename: Z
authors.initials: Z
authors.lastname: Král
authors.forename: I
authors.initials: I
authors.lastname: Vásová
authors.forename: R
authors.initials: R
authors.lastname: Hájek
authors.forename: Z
authors.initials: Z
authors.lastname: Adam
authors.forename: M
authors.initials: M
authors.lastname: Navrátil
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D009894:Opportunistic Infections / Q000276:immunology; D012189:Retrospective Studies; D012772:Shock, Septic / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Varovné príznaky predcházející rozvoj septického soku u neutropenických nemocných lécených pro hematologické malignity.