title: Scintigraphic, sonographic, and histologic evaluation of renal autotransplantation in cats.
abstract: OBJECTIVE
  To determine scintigraphic, sonographic, and histologic changes associated with renal autotransplantation in cats.
  
  
  METHODS
  7 adult specific-pathogen-free cats: 5 males, 2 females, 1 to 9 years old.
  
  
  METHODS
  Renal autotransplantation was performed by moving a kidney (5 left, 2 right) to the left iliac fossa. Before and at multiple times after surgery, for a total of 28 days, cats were evaluated by B-mode and Doppler ultrasonography, scintigraphy, and renal biopsy.
  
  
  RESULTS
  By 24 hours after surgery, a significant decrease (42%) in mean glomerular filtration rate (GFR) and an increase in mean renal size (81% increase in cross-sectional area) were evident in the transplanted kidney, compared with preoperative values. By postsurgery day 28, reduction in GFR was 23%. Significant changes in renal blood flow velocity were identified in both kidneys. Consistent changes in resistive index or pulsatility index for either kidney could not be identified. When all postoperative histologic data were combined, the histologic score, indicating degree and numbers of abnormalities detected, for the transplanted kidney was significantly higher than that for the control kidney.
  
  
  CONCLUSIONS
  Significant changes in renal function, size, and histologic abnormalities develop secondary to acute tubular necrosis in cats after uncomplicated renal autotransplantation.
  
  
  CONCLUSIONS
  Evaluation of renal size and function may be of benefit for clinical evaluation of feline renal transplant patients, whereas measurement of the resistive index may be of little clinical value.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida, Gainesville 32610, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Newell
authors.forename: G W
authors.initials: GW
authors.lastname: Ellison
authors.forename: J P
authors.initials: JP
authors.lastname: Graham
authors.forename: P E
authors.initials: PE
authors.lastname: Ginn
authors.forename: O I
authors.initials: OI
authors.lastname: Lanz
authors.forename: J M
authors.initials: JM
authors.lastname: Harrison
authors.forename: J S
authors.initials: JS
authors.lastname: Smith
authors.forename: J M
authors.initials: JM
authors.lastname: Van Gilder
mesh_terms: D000818:Animals; D001706:Biopsy; D002415:Cats; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000166:cytology* / Q000000981:diagnostic imaging; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D008297:Male; D011877:Radionuclide Imaging; D013997:Time Factors; D014182:Transplantation, Autologous; D018608:Ultrasonography, Doppler