title: Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease.
abstract: The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 micrograms/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 microM, respectively.
authors.forename: B S
authors.initials: BS
authors.lastname: Min
authors.forename: H J
authors.initials: HJ
authors.lastname: Jung
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Bok
authors.forename: C M
authors.initials: CM
authors.lastname: Ma
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Bae
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D000097245:Ursolic Acid
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D014315:Triterpenes; D000097245:Ursolic Acid; C013330:uvaol