title: Activation of in vivo Kupffer cell function by oral administration of Cordyceps sinensis in rats.
abstract: We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Kagota
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
authors.forename: M
authors.initials: M
authors.lastname: Kunitomo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006999:Hypocreales / Q000737:chemistry*; D007275:Injections, Intravenous; D007728:Kupffer Cells / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000254:growth & development; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000254:growth & development
chemical_list: D004365:Drugs, Chinese Herbal