The relationship of personality dimensions in adult male rhesus macaques to progression of simian immunodeficiency virus disease.
Studies of nonhuman primate personality have suggested that physiological correlates of relevant behavioral dimensions exist. The present study examined personality using techniques similar to those employed in human personality research. Adult male rhesus monkeys were each rated on 25 adjectives while living in their natal groups. Approximately 1.5 years later, 18 animals were inoculated with the simian immunodeficiency virus (SIV) and exposed to socially stable or socially unstable conditions. Behavior, viral load (SIV RNA), plasma cortisol concentrations, and the IgG response to SIV and to rhesus cytomegalovirus were measured at regular intervals. Multiple regression analyses revealed that the four personality dimensions (Sociability, Confidence, Equability, Excitability) were correlated with various measures. Following inoculation with SIV, animals higher in Sociability showed a more rapid decline in plasma cortisol concentrations, elevations in the anti-RhCMV IgG response, and a decline in SIV RNA. The results indicate that personality factors in rhesus monkeys do have physiological correlates that have significance for disease processes and that in the context of a social manipulation, Sociability, reflecting the tendency to engage in affiliative interactions, is an important factor in explaining outcome measures at early time points.
Capitanio
J P
JP
California Regional Primate Research Center, University of California, Davis, California 95616, USA.
Mendoza
S P
SP
Baroncelli
S
S
D000818:Animals; D018450:Disease Progression; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis; D008253:Macaca mulatta; D008297:Male; D010551:Personality / Q000502:physiology*; D012367:RNA, Viral / Q000096:biosynthesis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000473:pathology / Q000523:psychology*; D012919:Social Behavior; D012931:Social Environment
D007074:Immunoglobulin G; D012367:RNA, Viral; D006854:Hydrocortisone