title: Photodynamic therapy by topical aminolevulinic acid, dimethylsulphoxide and curettage in nodular basal cell carcinoma: a one-year follow-up study.
abstract: Fifty-eight patients with 119 nodular (2 mm or more in thickness) basal cell carcinomas successfully treated with photodynamic therapy were included in this 1-year follow-up study. The initial cure rate at 3-6 months was 92% after photodynamic therapy, which included an initial debulking procedure and topical application of dimethylsulphoxide in order to enhance penetration of 5-aminolevulinic acid (20% in cream) to which the lesions were exposed for 3 h prior to exposure to light. At examination 12-26 months (mean 17 months) after treatment 113 lesions (95%) were still in complete response. Six lesions (5%) had recurred, located on the face, scalp and ear. The cosmetic outcome was evaluated as excellent to good in 91%. Microscopic examination of biopsies taken from healed areas in 7 patients did not reveal any sign of damage in 5 and only minor alterations in 2.
authors.affiliation: Photodynamic Out-patient Clinic, Department of Surgical Oncology, The Norwegian Radium Hospital, Oslo.
authors.forename: A M
authors.initials: AM
authors.lastname: Soler
authors.forename: T
authors.initials: T
authors.lastname: Warloe
authors.forename: J
authors.initials: J
authors.lastname: Tausjø
authors.forename: A
authors.initials: A
authors.lastname: Berner
mesh_terms: D000287:Administration, Topical; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D003475:Curettage; D062109:Dermatologic Surgical Procedures; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012008:Recurrence; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid; D004121:Dimethyl Sulfoxide