title: Role for the oxyS gene in regulation of intracellular hydrogen peroxide in Escherichia coli.
abstract: Intracellular hydrogen peroxide is regulated in Escherichia coli by OxyR in response to the metabolic production of H2O2. Here, we show that the untranslated oxyS RNA controlled by OxyR has a role in this regulation. The oxyS transcript appears to affect the metabolic output of H2O2 rather than the removal of H2O2 by catalases-hydroperoxidases.
authors.affiliation: Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA. bgonzale@hsph.harvard.edu
authors.forename: B
authors.initials: B
authors.lastname: González-Flecha
authors.forename: B
authors.initials: B
authors.lastname: Demple
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D005838:Genotype; D006861:Hydrogen Peroxide / Q000378:metabolism*; D018384:Oxidative Stress; D012329:RNA, Bacterial / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012329:RNA, Bacterial; D012097:Repressor Proteins; D014157:Transcription Factors; C499299:oxyR protein, E coli; D006861:Hydrogen Peroxide