Modification of the effect of diazepam on the propofol-induced loss of the righting reflex in mice by diabetes.
The effect of diabetes on the effect of diazepam on the propofol-induced loss of the righting reflex was investigated. There was no significant difference in the duration of the propofol-induced loss of the righting reflex between non-diabetic and diabetic mice. Diazepam increased the duration of the propofol-induced loss of the righting reflex in both diabetic and non-diabetic mice. The diazepam-induced enhancement of the effect of propofol was significantly lower in diabetic mice than that in non-diabetic mice. These effects were antagonized by the pretreatment with flumazenil. Pretreatment with FG7142, a benzodiazepine receptor inverse agonist, attenuated the duration of the propofol-induced loss of the righting reflex in non-diabetic mice, but not in diabetic mice. These results suggest that the attenuation of the diazepam-induced enhancement of the duration of the propofol-induced loss of the righting reflex in diabetic mice may be due to the dysfunction of benzodiazepine receptors.
Ohsawa
M
M
Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501, Japan.
Kamei
J
J
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003975:Diazepam / Q000494:pharmacology*; D005442:Flumazenil / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011187:Posture / Q000502:physiology; D015742:Propofol / Q000494:pharmacology*; D011963:Receptors, GABA-A / Q000502:physiology; D012018:Reflex / Q000187:drug effects*
D018686:Anesthetics, Intravenous; D018757:GABA Modulators; D011963:Receptors, GABA-A; D005442:Flumazenil; D003975:Diazepam; D015742:Propofol