Primary Sjögren's syndrome and its lymphoid malignancy: a report of four cases.
OBJECTIVE
To evaluate the incidence and spectrum of malignancy of primary Sjögren's syndrome (pSS).


METHODS
250 pSS who were followed-up in Peking Union Medical College (PUMC) Hospital were analyzed.


RESULTS
Four of them were diagnosed with histopathological findings of 2 non-Hodgkin Lymphoma, 1 AILD, 1 multiple myeloma. Two died of secondary infection while receiving chemotherapy for lymphoma, 2 remained remitted.


CONCLUSIONS
The risk factors were persistent enlargement of major salivary glands, appearance of monoclonal serum lg, and disappearance of auto antibodies.
Dong
Y
Y
Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Zhao
Y
Y
Zeng
X
X
Sun
D
D
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000473:pathology*