Association between AGT T235 variant and microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus.
OBJECTIVE
To assess the association between the common variation in the gene encoding angiotensinogen, AGT, and the presence of microalbuminuria in Canadian Oji-Cree with type 2 diabetes mellitus.


METHODS
We compared the frequencies of the AGT promoter and M235T polymorphisms among three subgroups of adult Oji-Cree: 50 subjects who had type 2 diabetes with microalbuminuria, 6 subjects who had type 2 diabetes without albuminuria and 302 non-diabetic, normotensive subjects.


RESULTS
We found the AGT T235 allele was present at a significantly higher frequency, and that T235/T235 homozygotes were significantly more prevalent, among the subjects who had type 2 diabetes with microalbuminuria than among the subjects in the other two groups.


CONCLUSIONS
The findings suggest that the AGT T235 allele is a determinant of the nephropathy susceptibility related to type 2 diabetes in these aboriginal Canadians.
Hegele
R A
RA
Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, London, Ontario, Canada. robert.hegele@rri.on.ca
Harris
S B
SB
Hanley
A J
AJ
Zinman
B
B
D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000150:complications* / Q000235:genetics; D000808:Angiotensinogen / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007198:Indians, North American; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D000808:Angiotensinogen