Screening oocytes and preimplantation embryos for aneuploidy.
Pregnancy and live birth rates following in-vitro fertilization decline rapidly with advancing maternal age partly because of an increase in age-related aneuploidies occurring in female meiosis. Screening oocytes or preimplantation embryos for common aneuploidies is now possible by polar body or cleavage stage biopsy and multicolour fluorescence in-situ hybridization.
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Centre for Preimplantation Genetic Diagnosis, Department of Obstetrics and Gynaecology, Guy's, King's College and St Thomas Hospitals School of Medicine, King's College London, UK.
Ogilvie
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D000782:Aneuploidy; D001755:Blastocyst; D005260:Female; D006801:Humans; D009865:Oocytes; D011247:Pregnancy; D019836:Preimplantation Diagnosis