[The effects of clenbuterol on intramuscular collagen metabolism in denervated muscle].
In order to explore the effects of clenbuterol on intramuscular collagen metabolism in denervated skeletal muscles, a randomized, double-masked and placebo-controlled group were studied. Seventy-one patients with complete function loss in muscularcutaneous nerve resulted from brachial plexus injury were administered clenbuterol or placebo 60 micrograms Bid for more than 3 months. Biopsies of the biceps brachia muscle were performed at the beginning and end of this study. The biopsied muscles were processed with anti-collagen I and IV immunohistochemical stains and image analysis as well. The result showed that the collagen proliferation of both type I and IV was much reducible in the clenbuterol-treated group than that of the placebo-treated group (P < 0.05). It was concluded that clenbuterol could inhibit partially the proliferation of intramuscular collagens in denervated skeletal muscle.
Jiang
G
G
Department of Hand Surgery, Huashan Hospital, Shanghai Medical University, P. R. China.
Gu
Y
Y
Zhang
L
L
D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D001132:Arm; D001917:Brachial Plexus / Q000293:injuries*; D002976:Clenbuterol / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism*; D003714:Denervation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation* / Q000378:metabolism; D009133:Muscular Atrophy / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control
D000318:Adrenergic beta-Agonists; D003094:Collagen; D002976:Clenbuterol