[Inhibitory effect of astemizol in skin tests with histamine].
OBJECTIVE
To determine the effect of the astemizol to inhibit the cutaneous response to the histamine.


METHODS
We made a clinical assay in healthy adult subjects realising skin tests with histamine for prick (1 mg/ml) and intradermal (0.01 mg/ml) daily during the taking of astemizol 10 mg during 7 days and during 7 days after suspending it, as well as the day 14, 21 and 28. It was determined the inhibition and the reappearance of the cutaneous response.


RESULTS
They were 12 subjects with mean age of 36 years old +/- 11.2 SD. The complete inhibition was presented starting from the fourth day and most (79%) until the seventh day. The normal reaction, recovered in more than seven days but less than fourteen in 100%.


CONCLUSIONS
According to these results, the astemizol inhibits the skin reaction to the histamine from the first day in 50% of the subjects and its principal action is to the seventh day, while when suspend it the normal response it recovers in more than seven days.
Rodríguez Medina
R
R
Clínica de Asma y Alergia, Hospital General de Zona 30, Iztacalco, México, DF.
Lozada Andrade
S
S
Gasca Bauza
M R
MR
D000328:Adult; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D016589:Astemizole / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012867:Skin / Q000187:drug effects; D012882:Skin Tests
D018926:Anti-Allergic Agents; D016589:Astemizole; D006632:Histamine
Efecto inhibitorio del astemizol en pruebas cutáneas con histamina.