title: Delay of metabolism rate of ciclosporin by simvastatin in 7 Chinese healthy men.
abstract: OBJECTIVE
  To study the effects of simvastatin (Sim) on pharmacokinetics of ciclosporin (Cic).
  
  
  METHODS
  Seven healthy young volunteers took Cic 100 mg alone or in combination with Sim 10 mg in a randomized crossover study. The Cic concentrations in blood were determined by specific fluorescence polarization immunoassay. Data were analyzed with 3P87 program.
  
  
  RESULTS
  The blood concentration-time curve was fitted to open 2-compartment model, and the pharmacokinetic parameters of Cic alone and Cic + Sim were: Cmax (646 +/- 94) and (698 +/- 340) micrograms.L-1; Tmax (1.12 +/- 0.13) and (1.13 +/- 0.21) h; AUC (2.3 +/- 0.4) and (2.6 +/- 1.2) mg.h.L-1; T1/2 beta (12 +/- 6) and (23 +/- 8) h (P < 0.05).
  
  
  CONCLUSIONS
  Sim delays the metabolism rate of Cic when they are given simutaneously.
authors.affiliation: Department of Clinical Pharmacology, Zhujiang Hospital, First Military Medical University, Guangzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Xu
authors.forename: Z H
authors.initials: ZH
authors.lastname: Wu
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zou
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D016572:Cyclosporine / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics*; D008297:Male; D019821:Simvastatin / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D019821:Simvastatin