[The role of CDDP on cytotoxicity of TILs obtained from colorectal tumors].
The effects of intravenous injection of cisplatin (CDDP) and the incubated with CDDP in vitro on the epitopes and cytotoxicity of TIL obtained from eight colorectal tumor patients were detected respectively by flow cytometer. There was a significant increase in CD3+/CD8+ subset in TIL in patients receiving intravenous injection of CDDP. And the cytotoxicity of these TILs increased significantly. The cytotoxities were positively correlated with the amount of CD3+/CD8+ subset in TIL. Raji cells incubated with CDDP in vitro showed increased susceptibility to TIL induced lysis.
Xu
Z
Z
Department of General Surgery, Nanjing General Hospital, People's Liberation Army.
Qi
X
X
Liu
F
F
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D018655:Lymphocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002945:Cisplatin