title: Keloids and hypertrophic scars: review and treatment strategies.
abstract: Keloids and hypertrophic scars represent exuberant forms of scar formation that frequently are pruritic, painful, and occasionally form strictures. As well, they may result in significant cosmetic disfigurement. Recent years have seen an increased understanding in the molecular and biological mechanisms of keloidal scar formation, allowing for the development of more specific therapeutic options for these lesions. Despite these developments, keloids and hypertrophic scars remain difficult to manage. Clinical, histopathological, and biochemical features of keloids and hypertrophic scars, as well as treatment guidelines, are discussed.
authors.affiliation: Beth Israel Deaconess Medical Center, Chestnut Hill, MA 02467, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Urioste
authors.forename: K A
authors.initials: KA
authors.lastname: Arndt
authors.forename: J S
authors.initials: JS
authors.lastname: Dover
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D017439:Cicatrix, Hypertrophic / Q000503:physiopathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D003452:Cryosurgery / Q000379:methods; D004358:Drug Therapy; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D007372:Interferons / Q000008:administration & dosage; D007627:Keloid / Q000503:physiopathology* / Q000628:therapy*; D053685:Laser Therapy / Q000379:methods; D008297:Male; D011878:Radiotherapy; D019651:Plastic Surgery Procedures / Q000379:methods; D012008:Recurrence; D014945:Wound Healing / Q000502:physiology*
chemical_list: D000305:Adrenal Cortex Hormones; D007372:Interferons