title: Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases.
abstract: Five patients with dysembryoplastic neuroepithelial tumour (DNT) showing extensive secondary haemorrhage, a finding not previously associated with these neoplasms, are described. The clinical presentations, neuroimaging findings, and histopathological features of these patients are reviewed. One patient, a previously asymptomatic 12 year old girl, presented with an acute intracerebral haemorrhage into a DNT. A further four young adults with histories of intractable partial and generalised seizures dating from childhood showed significant chronic haemorrhages within DNT, the MRI appearances in one patient giving a false impression of a cavernoma. Histopathology disclosed vascular abnormalities within these tumours which, together with other factors discussed, may have predisposed these tumours to haemorrhage.
authors.affiliation: Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London.
authors.forename: M
authors.initials: M
authors.lastname: Thom
authors.forename: B
authors.initials: B
authors.lastname: Gomez-Anson
authors.forename: T
authors.initials: T
authors.lastname: Revesz
authors.forename: W
authors.initials: W
authors.lastname: Harkness
authors.forename: C J
authors.initials: CJ
authors.lastname: O'Brien
authors.forename: R
authors.initials: R
authors.lastname: Kett-White
authors.forename: E W
authors.initials: EW
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Stevens
authors.forename: F
authors.initials: F
authors.lastname: Scaravilli
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000503:physiopathology*; D018302:Neoplasms, Neuroepithelial / Q000473:pathology / Q000503:physiopathology*