[Effect of prokinetic drugs inhibiting dopaminergic system on gallbladder motility in subjects with duodenal ulcer].
The purpose of this study was to determine the effect prokinetic drugs inhibiting dopaminergic receptors on gallbladder volume in normal conditions. The study comprised 90 males, aged 20-26 years with duodenal ulcer disease in remission alloted into 3 groups, 30 subject each. The gallbladder volume was determined in group I after placebo or 10 and 20 mg or metoclopramide administration; in group II: placebo or 10 and 20 mg of domperidone and in group III after placebo or 50 and 100 mg of sulphiride administration. Gallbladder motility was assessed ultrasonographically from 15 minutes to 2 hours since placebo or drug administration. The effect of the studied prokinetic drugs in fasting on gallbladder motility was differentiated after metoclopramide no significant changes in gallbladder volume were observed; after domperidone in the dose of 20 mg a slight decrease of gallbladder volume was found, whereas after sulphiryde statistically significant decrease was detected.
Szabelska
K
K
Kliniki Chorób Infekcyjnych i Gastroenterologii IMW WAM w Lodzi.
Chojnacki
J
J
Grzegorczyk
K
K
Mamos
A
A
D000328:Adult; D004294:Domperidone / Q000494:pharmacology* / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005704:Gallbladder / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology* / Q000627:therapeutic use; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000627:therapeutic use; D013469:Sulpiride / Q000494:pharmacology* / Q000627:therapeutic use
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D004294:Domperidone; D013469:Sulpiride; D008787:Metoclopramide
Wpływ leków prokinetycznych hamujacych układ dopaminergiczny na czynność ruchowa pecherzyka zółciowego u osób z choroba wrzodowa dwunastnicy.