title: Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides.
abstract: OBJECTIVE
  To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).
  
  
  METHODS
  The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.
  
  
  RESULTS
  PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.
  
  
  CONCLUSIONS
  The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.
authors.affiliation: Laboratory of Neurobiology, Suzhou Medical College, China.
authors.forename: S
authors.initials: S
authors.lastname: Gong
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zhang
authors.forename: W P
authors.initials: WP
authors.lastname: Yin
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Yin
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Z L
authors.initials: ZL
authors.lastname: Gu
authors.forename: Z M
authors.initials: ZM
authors.lastname: Qian
authors.forename: P L
authors.initials: PL
authors.lastname: Tang
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007033:Hypothalamus, Middle / Q000502:physiology*; D007106:Immune Sera / Q000494:pharmacology; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000276:immunology / Q000502:physiology; D008297:Male; D017288:Pain Threshold; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D011124:Polyporaceae / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D007106:Immune Sera; D007376:Interleukin-2; D010455:Peptides; D011134:Polysaccharides