title: Soluble calcium/SMFP dentifrice: effect on enamel fluoride uptake and remineralization.
abstract: OBJECTIVE
  To evaluate in situ the effect of soluble calcium on fluoride uptake and remineralization by human dental enamel from a sodium monofluorophosphate (SMFP) dentifrice.
  
  
  METHODS
  Eight volunteers took part in this cross-over, double-blind design study performed in three phases of 45 days. During each phase of the experiment, the subjects wore an acrylic resin appliance containing four blocks of human dental enamel with artificial caries to evaluate fluoride uptake and remineralization by three dentifrices: SMFP containing CaCl2, SMFP, and placebo. After each phase, the enamel blocks were removed and the total fluoride uptake (ppm F) and microhardness (Knoop) were measured. Statistical analyses (ANOVA and Turkey's test) were done.
  
  
  RESULTS
  There was no statistically significant difference between SMFP-CaCl2 and SMFP treatments regarding the amount of fluoride and microhardness data of treated enamel blocks as well as their areas under the curves, although both differed significantly (P < 0.05) when they were compared with placebo. However, the SMFP-CaCl2 treatment demonstrated the highest values on fluoride uptake and microhardness data. Furthermore, the microhardness data demonstrated 50% and 40% of remineralization for SMFP-CaCl2 and SMFP dentifrices, respectively.
authors.affiliation: Faculty of Dentistry of Piracicaba, State University of Campinas-UNICAMP, Brazil.
authors.forename: R H
authors.initials: RH
authors.lastname: Koo
authors.forename: J A
authors.initials: JA
authors.lastname: Cury
mesh_terms: D000704:Analysis of Variance; D001682:Biological Availability; D002122:Calcium Chloride / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000737:chemistry* / Q000378:metabolism; D003745:Dental Enamel Permeability; D003802:Dentifrices / Q000737:chemistry / Q000493:pharmacokinetics*; D004311:Double-Blind Method; D004338:Drug Combinations; D005459:Fluorides / Q000737:chemistry / Q000493:pharmacokinetics*; D006244:Hardness; D006801:Humans; D008964:Molar, Third; D010710:Phosphates / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility; D014089:Tooth Remineralization
chemical_list: D003802:Dentifrices; D004338:Drug Combinations; D010710:Phosphates; C012980:fluorophosphate; D002122:Calcium Chloride; D005459:Fluorides