title: [TT virus infection in patients with hepatocellular carcinoma associated with non-A to G hepatitis: histopathological study].
abstract: To study if TTV infection is involved in the development of hepatocellular carcinoma (HCC), we tested the sera of 19 patients with HCC associated with non-A to G hepatitis for the presence of serum TTV DNA, and compared the blood chemistry values and liver histology of the patients in the TTV DNA-positive and -negative groups. Detection of TTV DNA was performed described as Nishizawa, et al method. TTV DNA was detected in the sera of 47.4%. There were no significant differences in the blood chemistry results and other tests between the TTV-positive and -negative patients. Histological examination of the non-tumor regions of the liver showed that there were no significant differences in the number of areas and characteristics of the necro-inflammatory reactions, the degree of staging and irregular regeneration of hepatocyte between the two groups. These results suggest that the development of HCC in patients with non-A to G hepatitis is not associated with TTV infection.
authors.affiliation: Third Department of Internal Medicine, Nihon University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: H
authors.initials: H
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000821:virology*; D004266:DNA Virus Infections / Q000473:pathology / Q000821:virology*; D004267:DNA Viruses / Q000302:isolation & purification; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D004279:DNA, Viral