The phenotypic characteristics of heterozygous reeler mouse.
Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-). These phenotypic traits are an approximately 50% decrease of brain Reln mRNA and Reln protein, an accumulation of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in subcortical white matter, an age-dependent decrease in prepulse inhibition of startle (PPI), and neophobic behavior on the elevated plus-maze. Possible analogies between these rl+/- phenotypic traits and signs of psychosis vulnerability are discussed.
Tueting
P
P
Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA.
Costa
E
E
Dwivedi
Y
Y
Guidotti
A
A
Impagnatiello
F
F
Manev
R
R
Pesold
C
C
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001362:Avoidance Learning; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009419:Nerve Tissue Proteins; D010641:Phenotype; D017397:Prefrontal Cortex / Q000378:metabolism; D014176:Protein Biosynthesis; D000091042:Reelin Protein; D013216:Reflex, Startle; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012697:Serine Endopeptidases; D014158:Transcription, Genetic
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D008058:Dihydrolipoamide Dehydrogenase; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases