title: Use of recombinant human cardiac Troponin T for standardization of third generation Troponin T methods.
abstract: The Elecsys Troponin T third generation assay uses recombinant human cardiac troponin T as standard material. The new assay has a linear calibration curve. Thus, linearity problems observed with the second generation assay have been eliminated. The assay has high precision, especially at the low end of measuring range (inter-assay CV < 10% at 0.1 microgram/L). The new standardization does not change the cut-off value of 0.1 microgram/L. The use of recombinant human cardiac troponin T as standard material enables a reproducible and reliable standardization of troponin T assays.
authors.affiliation: Roche Diagnostics GmbH, Werk Penzberg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Hallermayer
authors.forename: D
authors.initials: D
authors.lastname: Klenner
authors.forename: R
authors.initials: R
authors.lastname: Vogel
mesh_terms: D015415:Biomarkers; D002138:Calibration; D002624:Chemistry, Clinical / Q000592:standards*; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D016014:Linear Models; D011994:Recombinant Proteins; D012016:Reference Values; D015203:Reproducibility of Results; D020107:Troponin T / Q000032:analysis / Q000097:blood
chemical_list: D015415:Biomarkers; D011994:Recombinant Proteins; D020107:Troponin T