title: Is there more than one late radiation proctitis syndrome?
abstract: OBJECTIVE
  To investigate the significance of the various late rectal symptoms that appear after radical prostatic irradiation.
  
  
  METHODS
  Patients with localised prostate cancer treated between 1987 and 1994 at the Mater Hospital, Newcastle with radical megavoltage irradiation were recalled for examination and to complete a detailed questionnaire concerning late radiation-induced symptoms and their effects on normal daily life. The influence of patient age treatment related variables and acute proctitis symptoms occurring during therapy or the late symptoms recorded were assessed and the relationship between late symptoms and late EORTC/RTOG score and impact on normal daily life were studied.
  
  
  RESULTS
  The presence of symptoms of acute proctitis was the only factor to predict any of three late symptoms (urgency, frequency and diarrhoea) and late EORTC/RTOG score in this series (odds ratios: 1.7-2.57, P-values: 0.009-0.0007). Cluster and discriminant function analyses revealed the presence of five subgroups of patients with varying permutations of different late rectal symptoms, including one group with minimal symptoms (P < 0.0001). While bleeding and rectal discharge were the major contributors to late EORTC/RTOG score (P < 0.0001 and 0.04), faecal urgency and bleeding were the most important factors to impact on normal daily life (P < 0.0001 and P < 0.0003). A relatively low concordance was found between late EORTC/RTOG score and the patients' self assessment on the effect of their symptoms on their normal daily lives. Some late symptoms, including bleeding and rectal discharge become less prevalent after 3 years of follow-up with a resulting improvement in EORTC/RTOG score.
  
  
  CONCLUSIONS
  There may be more than one late (chronic) proctitis syndrome which may be linked in greater or lesser degrees to acute proctitis symptoms occurring during therapy. Urgency is a common late symptom which often has an important impact on normal daily life and deserves recognition in late normal tissue scoring systems. Assessment of the incidence of bleeding as a measure of late rectal morbidity following prostate irradiation may underestimate the impact of these chronic effects. Confirmatory studies are necessary.
authors.affiliation: Department of Radiation Oncology, Newcastle Mater Misericordiae Hospital, NSW, Australia.
authors.forename: J W
authors.initials: JW
authors.lastname: Denham
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: R H
authors.initials: RH
authors.lastname: Dunstan
authors.forename: J
authors.initials: J
authors.lastname: Johansen
authors.forename: A
authors.initials: A
authors.lastname: See
authors.forename: C S
authors.initials: CS
authors.lastname: Hamilton
authors.forename: S
authors.initials: S
authors.lastname: Bydder
authors.forename: S
authors.initials: S
authors.lastname: Wright
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D011349:Proctitis / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects; D011882:Radiotherapy, High-Energy; D012002:Rectal Diseases / Q000209:etiology