title: Steroidal saponins from the bulbs of Lilium candidum.
abstract: Five new spirostanol saponins and a new furostanol saponin were isolated from the fresh bulbs of Lilium candidum. Their structures were elucidated on the basis of spectroscopic analysis, including two-dimensional NMR spectroscopic techniques and the result of acid hydrolysis. The isolated saponins contained a branched triglycoside moiety assigned as O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->6)]-beta - D-glucopyranose with the formation of an O-glycosidic linkage to C-3 of the aglycone as the common structural feature. The inhibitory activity of the saponins on Na+/K+ ATPase was evaluated.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. mimakiy@ps.toyaku.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Mimaki
authors.forename: T
authors.initials: T
authors.lastname: Satou
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: Y
authors.initials: Y
authors.lastname: Sashida
authors.forename: Y
authors.initials: Y
authors.lastname: Hatakeyama
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008969:Molecular Sequence Data; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase