Effect of vitamin E on adriamycin- induced nephrotoxicity at the ultrastructural level in guinea pigs.
It is known that Adriamycin, which is widely used in the treatment of various neoplastic conditions, exerts toxic effects in several organs. In this study, we have established that vitamin E has some beneficial effects on the kidney by protecting it from some of the toxicity induced by Adriamycin. A study was carried out which comprised one control group and two experimental groups of guinea pigs. In the experiment Adriamycin was administered either alone (group II) or together with vitamin E (group III). The results of groups II and III were compared with controls (group I). The kidneys were subsequently removed and examined by routine electron microscopic techniques. We found that vitamin E administered together with Adriamycin could reverse some of the degenerative changes caused by Adriamycin.
Görgün
M
M
Department of Histology and Embryology, Gazi University Faculty of Medicine, Ankara, Turkey.
Erdogan
D
D
Abban
G
G
Türközkan
N
N
Elbeg
S
S
D000818:Animals; D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D007687:Kidney Tubules, Proximal / Q000473:pathology / Q000648:ultrastructure; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008854:Microscopy, Electron; D014810:Vitamin E / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D014810:Vitamin E; D008315:Malondialdehyde; D004317:Doxorubicin