[Radioprotective properties of phenoxane during low intensity low dose gamma irradiation].
The effect of prophylactic and therapeutic administration of phenoxane on the parameters of lipid peroxidation (LPO) regulatory system in murine tissues under low intensity gamma-irradiation (15 cGy) over a wide range of the agent doses is studied in dynamics. The different pattern of the phenoxane effect depending on its dose as well as the time of administration (before or after irradiation) is revealed with physiological tests (the dynamics of leucocyte amount, the blood formula, the change in spleen mass per mouse), on biochemical level (the changes in the LPO products content in murine blood and tissues), in biophysical properties (the lipid antioxidant activity level, the rate of oxygen consumption under the initiated oxidation of ethylbenzene in the presence of lipids from the intact and experimental murine organs) and also by the analysis of variability of the biochemical and biophysical properties in tissues and blood leucocytic formula within groups of mice.
Shishkina
L N
LN
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow.
Poliakova
N V
NV
Mazaletskaia
L I
LI
Bespal'ko
O F
OF
Kushnireva
E V
EV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010080:Oxazoles / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012062:Relative Biological Effectiveness
D000975:Antioxidants; D010080:Oxazoles; D011753:Pyrones; D011837:Radiation-Protective Agents; C077638:phenoxan
Protivoluchevye svoĭstva fenoksana pri nizkointensivnom gamma-obluchenii v maloĭ doze.