Transforming growth factor beta in infectious disease: always there for the host and the pathogen.
At the portals of pathogen entry, there are pools of the latent form of a potent cytokine, transforming growth factor beta (TGF-beta). Many infections activate these pools and stimulate further TGF-beta expression. As well as potent immunomodulation, activated TGF-beta might have important effects on pathogen entry, replication, persistence, latency and oncogenesis.
Fitzpatrick
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DR
Leukocyte Biology Unit of the Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Queensland 4029, Australia.
Bielefeldt-Ohmann
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D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology / Q000473:pathology; D002908:Chronic Disease; D003141:Communicable Diseases / Q000382:microbiology / Q000473:pathology*; D018450:Disease Progression; D005786:Gene Expression Regulation; D006801:Humans; D009857:Oncogenes; D010272:Parasitic Diseases / Q000469:parasitology / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000502:physiology*
D016212:Transforming Growth Factor beta