Efficacy of adhesive interactions in pig-to-human xenotransplantation.
Successful xenotransplantation depends on many factors, one being the interactions of cross-species adhesion molecule-ligand pairs. Depending on the approach used to facilitate xenotransplantation, these interactions can play differing roles. Here, André Simon, Anthony Warrens and Megan Sykes review the existing information on pig-to-human adhesive interactions and its implication for different approaches to pig-to-human xenotransplantation.
Simon
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AR
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, MGH East, Building 149-5102, 13th Street, Boston, MA 02129, USA. asimon@artificial-organs.de
Warrens
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AN
Sykes
M
M
D000818:Animals; D002448:Cell Adhesion / Q000235:genetics / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology; D006084:Graft Rejection / Q000235:genetics / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D016023:Integrins / Q000235:genetics / Q000276:immunology; D008024:Ligands; D013552:Swine; D014019:Tissue Donors; D014183:Transplantation, Heterologous / Q000009:adverse effects / Q000276:immunology*
D015815:Cell Adhesion Molecules; D016023:Integrins; D008024:Ligands