[TT virus (TTV) in Japanese haemophiliacs].
This study aimed to evaluate the prevalence and characteristics of infection with a novel virus designated TT virus (TTV) in Japanese haemophiliacs. TTV DNA was measured in 60 haemophiliacs by semi-nested PCR. HCV RNA, HGV RNA and HIV antibody were also tested. TTV DNA was detected in 35 haemophiliacs (58.3%). There were no differences in the backgrounds or characteristics between TTV DNA-positive and-negative haemophiliacs, except that levels of IgG and IgM in TTV DNA-positive patients were higher than those in TTV DNA-negative patients. In patients infected with TTV type 2, which is rare in Japan, the rate of coinfection with HCV of imported types was high. These indicate that TTV type 2 in Japanese haemophiliacs might have a foreign origin.
Yokozaki
S
S
Second Department of Internal Medicine, Nagoya University School of Medicine.
Fukuda
Y
Y
Hayakawa
T
T
Takamatsu
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002648:Child; D004266:DNA Virus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D004267:DNA Viruses / Q000235:genetics / Q000302:isolation & purification; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005838:Genotype; D006467:Hemophilia A / Q000150:complications* / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
D015415:Biomarkers; D004279:DNA, Viral