title: Syndrome of inappropriate secretion of antidiuretic hormone associated with amyotrophic lateral sclerosis in respiratory failure.
abstract: A 65-year-old man who had muscle weakness and dysarthria was admitted for investigation of motor neuron disease. He had lost 12 kg of weight in 6 months. Neurological findings disclosed upper and lower motor neuron disturbances with normal sensory nerve function, and needle electromyography showed a neurogenic pattern. Laboratory findings on admission demonstrated dilutional hyponatraemia due to an excessive secretion of antidiuretic hormone (ADH). Based on these findings, the patient was diagnosed as having the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with amyotrophic lateral sclerosis (ALS). During the night of first hospital day, the patient complained of severe dyspnoea, and mechanical ventilation was commenced. Following the mechanical ventilation, plasma ADH levels and serum sodium concentration were normalized. We propose that respiratory failure secondary to the atrophy of respiratory muscle might be responsible for the development of SIADH.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: B
authors.initials: B
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000175:diagnosis; D001784:Blood Gas Analysis; D003937:Diagnosis, Differential; D004576:Electromyography; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D008297:Male; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use; D012964:Sodium / Q000097:blood; D014667:Vasopressins / Q000097:blood
chemical_list: D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D012964:Sodium