Synthesis of 25-aminosterols, new antifungal agents.
25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 microM.
Beuchet
P
P
Laboratoire de Synthèse et Etude de Substances Naturelles à Activités Biologiques, Université de La Rochelle, France.
Dherbomez
M
M
Elkiel
L
L
Charles
G
G
Letourneux
Y
Y
D000935:Antifungal Agents / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D020128:Inhibitory Concentration 50; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008956:Models, Chemical
C121223:25-aminocholesterol; D000935:Antifungal Agents; C060268:25-aminolanosterol; D007810:Lanosterol; D002784:Cholesterol