Flurbiprofen, S(+), eyedrops: formulation, enantiomeric assay, shelf-life and pharmacology.
Aphakic cystoid macula edema, occurring after cataract extraction is ascribed to trauma-induced production of intra-ocular prostaglandins. Sufficient experimental and clinical evidence supports the use of prostaglandin synthesis inhibitors to countervail this clinical condition. The active S(+)-enantiomer of flurbiprofen, a prostaglandin synthesis inhibitor, has been formulated into a stereoselective, ballast free eyedrop solution in a concentration of 0.015%. Analysis by capillary zone electrophoresis shows shelf-life stability up to four years at room temperature of this enantiomer. The inhibitory effect on the synthesis of prostaglandins as measured on a homogenate bovine iris/ciliary body, remained unaffected during a shelf-life period of three years.
van Sorge
A A
AA
Rijnstate Hospital Dept of Pharmacy, Arnhem, The Netherlands.
Wijnen
P H
PH
van Delft
J L
JL
Coré-Bodelier
V M
VM
van Haeringen
N J
NJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D019075:Electrophoresis, Capillary; D005480:Flurbiprofen / Q000737:chemistry* / Q000494:pharmacology*; D066298:In Vitro Techniques; D009883:Ophthalmic Solutions / Q000737:chemistry* / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis*; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D011453:Prostaglandins; D005480:Flurbiprofen