Chronic lymphocytic leukaemia presenting with central nervous system involvement.
A 68-year-old man presented with hemiparesis, lymphocytosis, and cerebral lesions on MRI. Flow cytometry of blood, bone marrow and cerebrospinal fluid showed B-CLL lymphocytes with bright CD20 expression, sIg, and absence of CD23 antigen. Fluorescence in situ hybridisation showed trisomy 12 in 50% of analysed peripheral mononuclear cells. The patient died 6 months after the diagnosis. Rapidly progressive and fatal course of the disease was consistent with known bad prognostic significance of CD20 bright expression and trisomy 12.
Poplawska-Szczyglowska
L
L
Department of Lymphoproliferative Diseases, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Warsaw, Poland.
Walewski
J
J
Pienkowska-Grela
B
B
Rymkiewicz
G
G
Mioduszewska
O
O
D000368:Aged; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D002881:Chromosomes, Human, Pair 12; D017809:Fatal Outcome; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D008297:Male; D014314:Trisomy