Concentration at steady-state after periodic and non-uniform administration of drug.
A two-compartment model, with absorption from the gut and elimination from both compartments, is considered in order to express the concentration at any time and at steady-state when a drug is administered repeatedly according to a dosing schedule non-uniformly distributed over a 24-h interval. A time-delay is included to take into account the drug crossing from the gut to the central compartment.
Plusquellec
Y
Y
UFR de Mathématiques, Université Paul Sabatier, Toulouse, France.
De Biasi
J
J
Souhait
J
J
D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D006801:Humans; D007408:Intestinal Absorption; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015233:Models, Statistical; D010599:Pharmacokinetics