title: Anti-emetic principles of Pogostemon cablin (Blanco) Benth.
abstract: Bioassay-guided fractionation of anti-emetic extracts and constituents of 8 traditional Chinese herbal drugs was performed. Twenty extracts described in Table 1 showed anti-emetic activity on copper sulfate induced-emesis in young chicks. From the n-hexane extract of Pogostemon cablin, patchouli alcohol (1), pogostol (2), stigmast-4-en-3-one (3), retusin (4), and pachypodol (5) were tested and exhibited anti-emetic effects.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Koyama
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Tai
authors.forename: Y
authors.initials: Y
authors.lastname: Nunoura
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D002645:Chickens; D019327:Copper Sulfate / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008297:Male
chemical_list: D000932:Antiemetics; D004365:Drugs, Chinese Herbal; D019327:Copper Sulfate