Modeling and simulation in molecular pharmacology.
A stochastic simulation program of drug-receptor interaction is presented. The user can select a set of conditions concerning the processes of response release (type of cellular response, drug distribution and metabolism etc.) and the program plots a family of dose-response curves. A comparison between experimental and simulated dose-response curves shows the validity of the model can be used either for testing hypotheses concerning drug-receptor interaction, for experimental design or for estimation of some specific parameters. The program can also be used for educational purposes.
Mihalas
G I
GI
University of Medicine and Pharmacy, Timisoara, Romania. mihalas@asmt.sorostm.ro
Kygyosi
A
A
Lungeanu
D
D
Vernic
C
C
D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism*; D013269:Stochastic Processes
D004364:Pharmaceutical Preparations; D011955:Receptors, Drug