Human herpes virus-6 seroprevalence and leukaemias: a case-control study. GIMEMA (Gruppo Italiano Malattie Ematologiche dell' Adulto).
The relationships between acute myeloid leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML) and refractory anaemia with excess of blasts (RAEB) and human herpes virus (HHV)-6 antibody level were investigated in a multicentre case-control study. An association between increased HHV-6 seropositivity and geometric mean titre ratio with AML was shown: P for trend = 0.022, adjusted odds ratio 1.20, 95% confidence interval 1.07-1.33 respectively. No association was found between HHV-6 and ALL, CML or RAEB.
Gentile
G
G
Dipartimento di Biotecnologie Cellulari e Ematologia, Università La Sapienza, Roma, Italia.
Mele
A
A
Ragona
G
G
Faggioni
A
A
Zompetta
C
C
Tosti
M E
ME
Visani
G
G
Castelli
G
G
Pulsoni
A
A
Monarca
B
B
Martino
P
P
Mandelli
F
F
D000293:Adolescent; D000328:Adult; D000754:Anemia, Refractory, with Excess of Blasts / Q000453:epidemiology* / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology* / Q000821:virology; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000821:virology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000821:virology; D012307:Risk Factors; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral