[Possible molecular and cellular mechanisms of gene expression regulation during learning].
The learning plasticity was shown to be accompanied by a serotonin-induced translocation of Rf 0.58 protein, increasing of the G-protein activity, as well as PKA and c-fos gene expression in Helix. The learning marker Rf 0.58 is absent from the juvenile snails. The AP-1 transcription factors in them cannot be determined or induced with serotonin. The level of CRE factors in juvenile snails was comparable with adult and can be regulated by serotonin. The impossibility of sensitisation and avoidance conditioning reflex in juvenile snails can be explain with the AP-1 factors deficit.
Grinkevich
L N
LN
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Vasil'ev
G V
GV
D051698:Activating Transcription Factor 2; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004924:Escape Reaction / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006372:Helix, Snails; D009473:Neuronal Plasticity / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology; D018808:Transcription Factor AP-1 / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D051698:Activating Transcription Factor 2; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D016760:Proto-Oncogene Proteins c-fos; D018808:Transcription Factor AP-1; D014157:Transcription Factors; D012701:Serotonin; D017868:Cyclic AMP-Dependent Protein Kinases; D019204:GTP-Binding Proteins
Vozmozhnye molekuliarno-kletochnye mekhanizmy reguliatsii ékspressii genov pri obuchenii.