title: Ambulatory nocturnal oximetry and sleep questionnaire-based findings in 38 patients with end-stage renal disease.
abstract: BACKGROUND
  Patients with end-stage renal diseases (ESRD) have an increased risk of sleep-disordered breathing. With regard to this disorder, controversy persists about prevalence, cost-effective assessment and socio-economical relevance.
  
  
  METHODS
  Therefore, we performed, for the first time, overnight ambulatory oximetry in combination with a sleep questionnaire in 38 unselected patients with ESRD and 37 healthy controls. An oxygen desaturation index (ODI) >15, defined as >15 falls in oxygen saturation of > or =4% per h, was observed more frequently in ESRD patients than in healthy controls (47 vs. 3%, P<0.001).
  
  
  RESULTS
  In general, the results derived from the assessment of the Epworth Sleepiness Scale (ESS) as well as those from the visual analogue scale (VAS) did not reflect the ODI values of the respective patient population. Interestingly, 88% of ESRD patients with the questionnaire finding 'excessively loud snoring' had an ODI of >15 as compared with 13% without this complaint (P<0.05). Furthermore, 77% of ESRD patients with a systolic blood pressure >140 mm Hg and a body mass index (BMI) >25, had an ODI of >15. The percentage of ESRD patients with a professional activity was higher in the absence of sleep-disordered breathing (63 vs. 21%, P<0.05).
  
  
  CONCLUSIONS
  'Excessively loud snoring' and a BMI >25 combined with hypertension are risk factors for sleep-disordered breathing in ESRD patients. Nocturnal oxygen desaturations are assessed efficiently by ambulatory oximetry and correlate with relevant biological and socio-economical parameters in ESRD patients.
authors.affiliation: Department of Medicine, University of Bern, Inselspital, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Pfister
authors.forename: S M
authors.initials: SM
authors.lastname: Jakob
authors.forename: H P
authors.initials: HP
authors.lastname: Marti
authors.forename: F J
authors.initials: FJ
authors.lastname: Frey
authors.forename: M
authors.initials: M
authors.lastname: Gugger
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D012890:Sleep / Q000502:physiology*; D011795:Surveys and Questionnaires
chemical_list: D010100:Oxygen