Mechanisms of cell transformation by Herpesvirus saimiri.
Herpesvirus saimiri is a virus capable of inducing oncogenic transformation of T lymphocytes of New World primates and immortalizing human T cells in vitro. T lymphocytes immortalized by H. saimiri demonstrate functional biological responses to their antigens. Therefore, H saimiri-induced transformation of T cells emerges as a very powerful tool of T-cell biology. The mechanism of this transformation remains to be elucidated. However, it is apparent that H. saimiri proteins Tip and StpC are crucial for T-cell transformation. Potential mechanisms mediating the effects of Tip and StpC, as well as the possible role of other H. saimiri proteins, are discussed in this review.
Tsygankov
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Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA. tsygan@astro.ocis.temple.edu
Romano
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D018801:CD2 Antigens / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D016207:Cytokines / Q000096:biosynthesis; D006567:Herpesvirus 2, Saimiriine / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D017361:Viral Nonstructural Proteins / Q000502:physiology; D014764:Viral Proteins / Q000502:physiology
D018801:CD2 Antigens; D016207:Cytokines; D010750:Phosphoproteins; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; C094106:stp protein, Bacteriophage T4; C092384:tyrosine kinase interacting protein, Saimiriine herpesvirus 2; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)