Tissue norepinephrine turnover and cardiovascular responses during intermittent dehydration in the rat.
We investigated the central and peripheral sympathetic responses to intermittent dehydration in rats. The norepinephrine (NE) turnover, a biochemical index correlated with noradrenergic neuronal activity, was measured. The modification of blood pressure was also determined by telemetry during the different cycles of dehydration. Dehydration caused a decrease of NE turnover in A2, A5 and A6 nuclei and in peripheral organs. The vasopressinergic level of dehydrated rats decreased in hypophysis and hypothalamus, and increased in plasma. A repeated gradual increase of arterial blood pressure during the first three days of dehydration, followed by a sudden drop when the rats were rehydrated on the fourth day was observed. In conclusion, our study revealed an increase in blood pressure and in central sympathetic activity during dehydration.
Gharbi
N
N
Département de Biologie, Fac. Sciences, Tunis, Tunisie.
Somody
L
L
El Fazaâ
S
S
Kamoun
A
A
Gauquelin-Koch
G
G
Gharib
C
C
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D003681:Dehydration / Q000378:metabolism* / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism; D010953:Plasma Volume / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000503:physiopathology
D001127:Arginine Vasopressin; D009638:Norepinephrine