Distribution of activated T cells migrating through the body: a matter of life and death.
The preferential distribution of lymphocyte subsets in tissues is attributed to a selective lymphocyte-endothelium interaction during entry. However, proliferation and death within the tissue, and exit from the tissue, might also play a role. Here, Jürgen Westermann and Ulrike Bode provide evidence that preferential survival in the tissue of initial stimulation is the major factor in the preferential distribution of activated T cells.
Westermann
J
J
Centre of Anatomy, Medical School of Hannover 4120, 30623 Hannover, Germany. 101565.506@Compuserve.com
Bode
U
U
D000818:Animals; D017209:Apoptosis; D002465:Cell Movement; D006801:Humans; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology*