title: [TTV materno-infantile infection--a study on the TTV frequency in Japanese pregnant women and the natural history of TTV mother-to-infant infection].
abstract: We preliminarily describe the frequency of TTV in Japanese pregnant women, non-parenteral, postnatal materno-infantile transmission of TTV, and 2 cases in which infantile development of the TTV carrier-state seemed to have occurred by vertical infection. The sera of 85 hepatitis B, C and G-positive and 36 non-pathological pregnant Japanese women were screened for the presence of TTV DNA with a use of semi-nested PCR. The positive rates were 25.9 and 27.8%, respectively. No significant differences were gained between these two groups. Twenty-one infants were born to the TTV carrier women. Of them, 9 infants (42.9%) sero-converted to TTV DNA-positive after their age of 4 months. Among the infants who were breast-fed, the positive sero-conversion rate of TTV DNA tended to increase as the length of the breast feeding period increased. Serum AST/ALT levels stayed within normal upper limits in the 9 infants. This study indicates the frequent, and furthermore, certain possibility of non-parenteral (i.e., via breast milk), postnatal vertical infection of TTV.
authors.affiliation: Department of Obstetrics and Gynecology, Dokkyo University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Inaba
authors.forename: K
authors.initials: K
authors.lastname: Oshima
authors.forename: Y
authors.initials: Y
authors.lastname: Okajima
authors.forename: T
authors.initials: T
authors.lastname: Nagase
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001942:Breast Feeding; D002353:Carrier State / Q000821:virology; D004266:DNA Virus Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D004267:DNA Viruses / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006525:Hepatitis, Viral, Human / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007564:Japan / Q000453:epidemiology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious
chemical_list: D015415:Biomarkers; D004279:DNA, Viral