title: The prognostic value of gastrointestinal morbidity for gastric cancer.
abstract: OBJECTIVE
  A history of gastrointestinal disease is a risk factor for organic gastrointestinal disorders overall. We conducted a retrospective case-control study to explore whether a history of gastrointestinal disease is of prognostic value for gastric cancer.
  
  
  METHODS
  Forty-six patients with gastric cancer were identified from a dynamic population of approximately 12,000 patients followed since 1971 in four general practices. The control subjects without gastric cancer were matched one-on-one according to age, general practice, sex and observation period. Data on gastrointestinal morbidity in the period before gastric cancer was diagnosed were obtained from the Continuous Morbidity Registration.
  
  
  RESULTS
  The mean observation period between the date of enrolment in the registration and the first diagnosis of gastric carcinoma was 12 years. Although every patient with gastric cancer ultimately will develop gastrointestinal complaints, 28 of these patients had no previous gastrointestinal morbidity, in comparison with 26 control subjects. Furthermore, patients who developed gastric cancer did not have more frequent gastrointestinal morbidity in their past than the control subjects (odds ratio 0.80, 95% CI 0.32-2.03).
  
  
  CONCLUSIONS
  Our results suggest that a history of gastrointestinal morbidity is not of prognostic value for gastric cancer. Focusing attention on patients with a past history of gastrointestinal symptoms to detect gastric cancer may be of little value.
authors.affiliation: Department of Gastroenterology, University Hospital Nijmegen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Laheij
authors.forename: J B
authors.initials: JB
authors.lastname: Jansen
authors.forename: E H
authors.initials: EH
authors.lastname: van de Lisdonk
authors.forename: J L
authors.initials: JL
authors.lastname: Severens
authors.forename: A L
authors.initials: AL
authors.lastname: Verbeek
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009426:Netherlands / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology