title: New AccI polymorphism in the follicle-stimulating hormone beta-subunit gene and its prevalence in three Southeast Asian populations.
abstract: A thymine-cytosine substitution was identified in exon 3 (codon 76, TAT to TAC) of the human follicle-stimulating hormone (FSH) beta-subunit gene. The nucleotide change led to creation of an AccI digestion site. The frequencies of the A allele (with AccI site) in Chinese (n = 201), Malays (n = 168) and Indians (n = 132) were 0.358, 0.333 and 0.402, respectively. The new FSH beta-subunit marker may be useful in gene tracking and association studies.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Singapore.
authors.forename: W X
authors.initials: WX
authors.lastname: Liao
authors.forename: Y
authors.initials: Y
authors.lastname: Tong
authors.forename: A C
authors.initials: AC
authors.lastname: Roy
authors.forename: S C
authors.initials: SC
authors.lastname: Ng
mesh_terms: D000483:Alleles; D001210:Asia, Southeastern; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000235:genetics* / Q000378:metabolism; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D017354:Point Mutation; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
chemical_list: D005640:Follicle Stimulating Hormone; D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C067488:GTMKAC-specific type II deoxyribonucleases