Physiologic consequences of pneumonectomy. Consequences on the pulmonary function.
When pneumonectomy is done in children, there is some speculation that lung growth occurs. In the adult population, volume response is incomplete and attributable to alveolar distention rather than multiplication. Stretch is widely regarded as the initial stimulus for compensatory growth. The authors review data pertaining to the physiology of the various adjustments that occur after pneumonectomy gathered both from observations on human response and from experimental findings in animals. Mechanisms and mediators of this adaptive response are discussed.
Tronc
F
F
Division of Thoracic Surgery, Centre de pneumologie de L'Hôpital Laval, Sainte-Foy, Quebec, Canada.
Grégoire
J
J
Leblanc
P
P
Deslauriers
J
J
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008171:Lung Diseases / Q000503:physiopathology* / Q000601:surgery*; D008176:Lung Volume Measurements; D011013:Pneumonectomy / Q000009:adverse effects*; D013997:Time Factors