Design of scytalone dehydratase inhibitors as rice blast fungicides: derivatives of norephedrine.
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
Basarab
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E.I. DuPont de Nemours Agricultural Products, Stine-Haskell Research Center, Newark, DE 19714, USA.
Jordan
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Gehret
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Schwartz
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Wawrzak
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D000935:Antifungal Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006836:Hydro-Lyases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D010665:Phenylpropanolamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D010935:Plant Diseases
D000935:Antifungal Agents; D010665:Phenylpropanolamine; D006836:Hydro-Lyases; C082741:scytalone dehydratase