Antineutrophil cytoplasmic antibodies in diffuse panbronchiolitis.
BACKGROUND
There are some reports of the coexistence of chronic suppurative lung diseases such as cystic fibrosis and systemic vasculitis. Diffuse panbronchiolitis has the same characteristics as chronic recurrent sinopulmonary infection and respiratory bronchiolitis.


METHODS
Serum samples from 30 patients with diffuse panbronchiolitis and 57 patients with other pulmonary diseases were tested to find the titer of myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA).


RESULTS
We found MPO-ANCA positivity in 4 patients with diffuse panbronchiolitis but not in those with other pulmonary diseases.


CONCLUSIONS
Our findings show that MPO-ANCA is positive in some patients with diffuse panbronchiolitis. Careful attention should be paid to the combination of chronic pulmonary infection and various vasculitis.
Sugiyama
Y
Y
Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.sugiyuki@jichi.ac.jp
Kitamura
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D001988:Bronchiolitis / Q000201:enzymology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000201:enzymology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000032:analysis
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase