[Antimutagenic effects of beta-carotene from Dunaliella salina].
OBJECTIVE
To study the genotoxic and antimutagenic efficts of beta-carotene from Dunaliella salina (beta-CDS).


METHODS
The in vitro micronucleus and chromosomal aberration tests in hunman lymphocytes were adopted. The effect of beta-CDS on mutagensis induced by gamma-rays and mitomycin (Mit) was studied.


RESULTS
beta-CDS (1-30 mg.L-1) had no genotoxicity, but inhibited spontaneous and gamma-ray-induced micronucleus fromation and Mit-induced chromosomal aberrations in human lymphocytes in vitro. The genotoxic action of synthetic beta-carotene (S beta C) was suppressed, the antimutagenic effects were heightened when S beta C and beta-carotene oil (beta CO, one of the beta-CDS compositions) were mixed in proportion as 80:27.5.


CONCLUSIONS
beta-CDS is an antimutagenic agent.
Ma
G J
GJ
Jiangsu Institute of Cancer Research, Nanjing, China.
Xue
K X
KX
Wu
J Z
JZ
Yuan
S
S
Qin
H L
HL
D000328:Adult; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000460:Chlorophyta / Q000737:chemistry; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008297:Male; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D019207:beta Carotene / Q000302:isolation & purification / Q000494:pharmacology*
D016587:Antimutagenic Agents; D019207:beta Carotene