title: Antioxidant activity of michellamine alkaloids.
abstract: The alkaloids michellamines A, B, and C are natural products isolated from a Central African tropical plant Ancistrocladus korupensis. We have investigated the radical scavenging ability of these compounds. The alkaloids inhibited the azo-induced oxidation of beta-phycoerythrin with IC50 values in the 0.5- to 0.8-microM range. Michellamine B also protected rat liver mitochondria against lipid peroxidation induced by adenosine diphosphate and Fe2+. The alkaloids were more potent antioxidants in these assays than several compounds being considered clinically as chemoprevention agents.
authors.affiliation: Biochemistry Department, Southern Research Institute, Birmingham, AL 35205, USA. white@sri.org
authors.forename: E L
authors.initials: EL
authors.lastname: White
authors.forename: L J
authors.initials: LJ
authors.lastname: Ross
authors.forename: P D
authors.initials: PD
authors.lastname: Hobbs
authors.forename: V
authors.initials: V
authors.lastname: Upender
authors.forename: M I
authors.initials: MI
authors.lastname: Dawson
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D000975:Antioxidants; D007546:Isoquinolines; D009281:Naphthalenes; C072235:michellamine A