Drug-induced hemolytic anemias: increasing complications to therapeutic interventions.
There are recent reports of severe drug-induced immune hemolysis caused by several different classes of drugs. Second and third generation cephalosporins, diclofenac, fludarabine, carboplatin, and beta-lactamase inhibitors are among the drugs associated with severe or fatal hemolysis. Studies on patients who exhibit hemolysis after ingesting these drugs indicate that the four classical mechanisms of drug-induced hemolytic anemia may overlap. These studies appear to support the unified theory for induction of drug-induced immune hemolytic anemia.
Wright
M S
MS
University of Louisville Clinical Laboratory Science Program, KY 40292, USA. michellew@netscape.net
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000276:immunology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D002511:Cephalosporins / Q000009:adverse effects; D002648:Child; D004008:Diclofenac / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D018448:Models, Immunological
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D002511:Cephalosporins; D004008:Diclofenac