title: Cytological and immunocytochemical evaluation of thyroid and breast masses in patients with a previous neoplasm: case reports.
abstract: The diagnosis of secondary tumours represents one of the most important fields in the application of fine needle aspiration cytology (FNAC). We studied two patients, one with a history of breast cancer and one with a previous tumour of the thyroid, who showed a second mass, in the thyroid and in the breast, respectively, during follow up. The aim of our study was to evaluate if cytology, performed on FNAC smears, may distinguish a metastatic lesion from a second primary tumour, or if further immunocytochemistry should be performed. Our data demonstrate that, while cytology may be indicative of a second primary tumour, the histotype should be confirmed by immunocytochemical staining.
authors.affiliation: Department of Experimental Medicine, University of Rome La Sapienza, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Pisani
authors.forename: A
authors.initials: A
authors.lastname: Antonaci
authors.forename: N T
authors.initials: NT
authors.lastname: Sinopoli
authors.forename: M
authors.initials: M
authors.lastname: Mottolese
authors.forename: A
authors.initials: A
authors.lastname: Vecchione
authors.forename: M R
authors.initials: MR
authors.lastname: Giovagnoli
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005656:Fungal Proteins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology*; D029701:Saccharomyces cerevisiae Proteins; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D005656:Fungal Proteins; C087579:MBR1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D016159:Tumor Suppressor Protein p53; D013954:Thyroglobulin