[Comparison of the effects of BI-6, a new asymmetric bipyridine oxime, with HI-6 oxime and obidoxime in combination with atropine on soman and fosdrine toxicity in mice].
The therapeutic efficacy of the new asymmetric bispyridinium oxime BI-6 against acute toxicity of the highly toxic organophosphate soman and the organophosphorus insecticide fosdrin by means of affecting the LD50 values of these noxiores substances was compared with the effect of the hitherto most perspective oxime HI-6 and the classic obidoxime always in combination with the identical dose of atropine. At the equimolar level the effect of oxime BI-6 against fosdrin completely equals the effects of both oximes HI-6 and obidoxime. The effect of oxime BI-6 against soman is even more marked than the effect of HI-6 but this difference is not statistically significant. On the other hand, at the equi-effective level, the effect of oxime BI-6 against soman is statistically significantly lower than the effect of HI-6, and against fosdrin it is even lower than the effect of both remaining oximes. The effects of the new oxime BI-6 equal, or slightly exceed the therapeutic effect of HI-6 but at the equimolar level only. At the equi-effective level which respects the toxicity of the oxime and is therefore more important for practical use, it is a therapeutically weaker reactivator of acetylcholinesterase than HI-6.
Kassa
J
J
Vojenská lékarská akademie JEP, Hradec Králové.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008799:Mevinphos / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010091:Oximes; D011726:Pyridinium Compounds / Q000494:pharmacology*; D012999:Soman / Q000633:toxicity*
C118647:BI 6; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D007306:Insecticides; D010091:Oximes; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; D008799:Mevinphos; D001285:Atropine; D012999:Soman; C022870:asoxime chloride
Srovnání úcinku nového asymetrického bispyridiniového oximu BI-6 s oximem HI-6 a obidoximem v kombinaci s atropinem na toxicitu somanu a fosdrinu u mysí.