Visual field responses to a hand vibration stimulus.
Two short visual field tests were performed on 106 subjects approximately 5 minutes apart with or without a hand vibration stimulus between the field tests. There were 31 eyes in the control group (10 without glaucoma, eight glaucoma suspects, 10 with primary open-angle glaucoma, and three with secondary open-angle glaucoma). There were 75 eyes in the hand vibration group (16 without glaucoma, 20 glaucoma suspects, 25 with primary open-angle glaucoma, eight with secondary open-angle glaucoma, three with normal-tension glaucoma, and three with other forms of glaucoma). Average visual field sensitivities were significantly reduced in the arcuate zones after a hand vibration stimulus (-0.42 dB; SD, 1.26 dB) when compared with sensitivities in the arcuate zones in subjects without the hand vibration stimulus (+0.38 dB; SD, 1.53 dB; P = 0.01). Multivariate analysis demonstrated a significant reduction in this response in the arcuate zone associated with use of betaxolol (P = 0.021) and timolol (P = 0.047). Betaxolol was associated with significantly smaller reductions in visual field sensitivities in the paracentral zone (P = 0.01). Reductions in visual field sensitivities that may be related to ocular vasospasm occurred after a hand vibration stimulus. This response may be able to be modified pharmacologically with topical beta-blockers, particularly betaxolol.
Chai
E
E
Sydney Hospital, NSW, Australia.
Goldberg
I
I
Chia
A
A
Chen
J
J
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006225:Hand; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D009898:Optic Disk / Q000098:blood supply / Q000503:physiopathology; D012720:Severity of Illness Index; D014661:Vasoconstriction; D014732:Vibration; D014794:Visual Fields / Q000502:physiology*
D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions