[Early signs of systemic disease in patients taking minocycline chlorhydrate].
BACKGROUND
Search for etiology in young subjects with joint disease must take into consideration causes other than reactional arthropathy or systemic disease.


METHODS
Two young subjects consulted for joint pain involving various joints. Physical examination did not reveal any other abnormality. Serum tests were positive for antinuclear antibodies and/or showed moderately and persistently elevated transaminases. History taking revealed that these subjects had been taking minocyclin chlorhydrate for several months, or even years, for acne. Joint pain subsided with drug withdrawal and serum tests returned to normal.


CONCLUSIONS
Long-term treatment with minocylin chlorhydrate should always be included in the search for an etiology in patients presenting joint pain.
Service de Médecine interne, CHU Bocage, Dijon.
B
B
Bonnotte
A C
AC
Gresset
B
B
Chauffert
J M
JM
Courtois
F
F
Martin
E
E
Collet
C
C
Sgro
B
B
Lorcerie
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000974:Antibodies, Antinuclear / Q000097:blood; D018771:Arthralgia / Q000097:blood / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects*; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood
D000974:Antibodies, Antinuclear; D000637:Transaminases; D008911:Minocycline
Symptômes évocateurs de maladie de système chez des patientes prenant du chlorhydrate de minocycline.