[Betaxolol treatment of hypertension in postmenopausal women].
OBJECTIVE
The study of hypotensive efficacy of high-cardioselective beta-blocker betaxolol, its effects on lipid and carbohydrate metabolism, menopausal syndrome in females with mild and moderate arterial hypertension.


METHODS
20 postmenopausal 45-59-year-old women entered the trial of betaxolol. They had diastolic blood pressure 90-114 mm Hg. Beta-blockers were not contraindicated. Arterial pressure, heart rate, body mass, blood lipid spectrum, glucose and insulin levels were evaluated before the treatment, 1, 3 and 6 months after it.


RESULTS
Betaxolol safely and effectively lowered blood pressure. Blood lipid spectrum remained unchanged. A transitory rise in fasting insulin levels did not worsen glucose tolerance despite a small gain in body mass. Menopausal syndrome relieved due to good effect of betaxolol on vasomotor disorders.


CONCLUSIONS
Betaxolol has a good hypotensive effect in the absence of adverse effects on lipid and carbohydrate metabolism. A reduction of menopausal syndrome was also achieved.
M M
MM
Bystrova
A N
AN
Britov
V M
VM
Gorbunov
A V
AV
Lebedev
N A
NA
Eliseeva
V A
VA
Metel'skaia
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D015784:Betaxolol / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects; D012449:Safety; D013577:Syndrome; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D015784:Betaxolol
Primenenie betaksolola u zhenshchin s arterial'noĭ gipertonieĭ v postmenopauze.