Development of the ovarian follicular epithelium.
A lot is known about the endocrine control of the development of ovarian follicles, but a key question now facing researchers is which molecular and cellular processes take part in control of follicular growth and development. The growth and development of ovarian follicles occurs postnatally and throughout adult life. In this review, we focus on the follicular epithelium (membrana granulosa) and its basal lamina. We discuss a model of how granulosa cells arise from a population of stem cells and then enter different lineages before differentiation. The structure of the epithelium at the antral stage of development is presented, and the effects that follicle growth has on the behavior of the granulosa cells are discussed. Finally, we discuss the evidence that during follicle development the follicular basal lamina changes in composition. This would be expected if the behavior of the granulosa cells changes, or if the permeability of the basal lamina changes. It will be evident that the follicular epithelium has similarities to other epithelia in the body, but that it is more dynamic, as gross changes occur during the course of follicle development. This basic information will be important for the development of future reproductive technologies in both humans and animals, and possibly for understanding polycystic ovarian syndrome in women.
Department of Medicine, Flinders University of South Australia, Bedford Park, Australia. ray.rodgers@flinders.edu.au
R J
RJ
Rodgers
T C
TC
Lavranos
I L
IL
van Wezel
H F
HF
Irving-Rodgers
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D004847:Epithelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D006080:Ovarian Follicle / Q000166:cytology* / Q000254:growth & development; D013234:Stem Cells / Q000166:cytology / Q000502:physiology