[Drug prescriptions and costs in diabetic polyneuropathy].
OBJECTIVE
Numerous medications are used in the treatment of diabetic polyneuropathy (PNP) without evidence of their efficacy. This study was undertaken to obtain the costs of drugs prescribed to patients with PNP throughout the Federal Republic of Germany in primary-care practices.


METHODS
Data (stored in the Medi-Plus data bank of the Institute for Medical Statistics, Frankfurt) from 400 primary-care practices were analysed for the year 1996 with regard to diagnoses and prescriptions for 40,112 diabetics over the age of > or = 20 years. A polyneuropathy (PNP) had been diagnosed in 3548 patients (8.8%) (age: 68 +/- 12 years, 56% women). The cost of medications listed for the treatment of PNP was identified and extrapolated to the total prescription cost for treated diabetic PNP in the whole of Germany. In addition the proportion of costs for drugs with unproven efficacy was calculated.


RESULTS
Antidepressives were prescribed for 13%, carbamazepine for 4%, and lipoic (thioctic) acid for 41% of diabetics with PNP. Annual costs per patient (mean value) were DM 203 for lipoic acid, DM 53 for vasoactive drugs and DM 42 for analgesics. Projection for the estimated total number of diabetic patients with PNP treated in primary care practices (n = 361,400) gave a total cost of DM 116 million (95% confidence limit: DM 109-123), of which DM 41 million (35%) was for medications of unproven efficacy.


CONCLUSIONS
In Germany one third of drug costs for diabetic patients with PNP in primary care is for medications of unproven efficacy. Cost-effective guidelines for the treatment of diabetic PNP are urgently required.
Abteilung Biometrie und Epidemiologie, Diabetes Forschungsinstitut an der Heinrich Heine Universität Düsseldorf. rath@dfi.uni-duesseldorf.de
W
W
Rathmann
B
B
Haastert
G
G
Giani
D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000191:economics; D000928:Antidepressive Agents / Q000191:economics; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000191:economics*; D016527:Drug Costs / Q000706:statistics & numerical data*; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D008063:Thioctic Acid / Q000191:economics
D000700:Analgesics; D000928:Antidepressive Agents; D008063:Thioctic Acid
Arzneimittelverordnungen und Kosten bei diabetischer Polyneuropathie.