111In-labelled platelets for assessment of thrombogenicity of new haemodialysis vascular access.
Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showed significantly higher platelet uptake (after 4 h: 2.4 +/- 1.1 vs 1.2 +/- 1.1 eU, P < 0.05; after 24 h: 2.1 +/- 1.0 vs 0.6 +/- 0.8 eU, P < 0.01) and a higher Doppler flow (1184 +/- 202 vs 609 +/- 342 ml.min-1, P < 0.001). In 8 of 39 accesses, a thrombosis occurred. Accumulation of activity was not related to shunt thrombosis (specificity 61%, sensitivity 71%). We conclude that 111In-platelet scintigraphy is not suitable for the early detection of shunt thrombosis or for identifying patients at risk.
Department of Nuclear Medicine, University of Vienna, Austria.
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Neumann
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Meisl
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Kopriva
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Manker
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Sinzinger
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001164:Arteriovenous Fistula / Q000000981:diagnostic imaging* / Q000209:etiology; D001792:Blood Platelets; D001794:Blood Pressure; D002408:Catheters, Indwelling / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation*; D013927:Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology; D013997:Time Factors; D018608:Ultrasonography, Doppler
D007205:Indium Radioisotopes