Identification of a new, unorthodox member of the MAGE gene family.
Several tumor-associated antigen families, such as MAGE, GAGE/PAGE, PRAME, BAGE, and LAGE/NY-ESO-1, exist. These antigens are of particular interest in tumor immunology, because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells only. We have identified a novel member of the MAGE gene family, MAGED1. Northern hybridization and RT-PCR demonstrated that the expression level of MAGED1 in different normal adult tissues is comparable to that in testis and fetal liver. Thus, MAGED1 does not possess an expression pattern characteristic of previously identified MAGE family genes, suggesting that the biology of the MAGE-family genes is more complex than previously thought. Chromosome mapping linked MAGED1 to marker AFM119xd6 (DXS1039) on chromosome Xp11.23.
Brentwood Biomedical Research Institute, Division of Hematology and Oncology, Veterans Affairs West Los Angeles Medical Center, 11301 Wilshire Boulevard, 111-H, Los Angeles, California 90073, USA. Maalpold@msn.com
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Põld
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Zhou
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Chen
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Hall
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Vescio
J R
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Berenson
D000328:Adult; D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D005260:Female; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D005796:Genes / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D012313:RNA / Q000235:genetics / Q000378:metabolism; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014960:X Chromosome / Q000235:genetics
D000951:Antigens, Neoplasm; D018076:DNA, Complementary; C120897:MAGED1 protein, human; D009363:Neoplasm Proteins; D012313:RNA