Videoendoscopic analysis of nasal steroid distribution.
Topical corticosteroids are one of the main pillars in the treatment of nasal polyps. The exact topography of their intranasal deposition has not yet been adequately visualised. The intranasal distribution of a 1% sodium fluorescein solution applied with original Pulmicort Topinasal (budesonide) metered pump bottles was analysed by videoendoscopy. The study group included eight healthy subjects and ten patients who had undergone endonasal sinus surgery. Videoendoscopy was performed in the study group within the first minute after application of the fluorescein solution. Additionally the deposition pattern of Pulmicort Topinasal was analyzed using a nasal model. The examination showed that the majority of the substance is deposited on the anterior portion of the nasal septum and the head of the inferior turbinate. Only a small fraction actually reaches the middle meatus. The distribution is improved by application during the decongested phase of the nasal cycle, after use of vasoconstricting nasal drops and maintaining a spraying angle of 45 degrees upwards. The development of new delivery techniques and systems could improve the efficacy of intranasally administered corticosteroids and reduce the complication rate.
Department of Otorhinolaryngology, Head and Neck Surgery, Facial Plastic Surgery and Communication Disorders, Fulda Hospital, Academic Teaching Hospital of the University of Marburg, Germany.
R
R
Weber
R
R
Keerl
R
R
Radziwill
B
B
Schick
D
D
Jaspersen
K
K
Dshambazov
G
G
Mlynski
W
W
Draf
D000281:Administration, Intranasal; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019819:Budesonide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008953:Models, Anatomic; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009298:Nasal Polyps / Q000188:drug therapy* / Q000601:surgery; D012016:Reference Values; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D016896:Treatment Outcome; D014741:Video Recording
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D019819:Budesonide