[Cerebrospinal fluid analysis in Kirisawa-Urayama type uveitis].
OBJECTIVE
We investigated whether viral encephalitis could occur in patients with Kirisawa-Urayama type uveitis by analysing the cerebrospinal fluid (CSF).


METHODS
CSF samples were aspirated from nine patients with Kirisawa-Urayama type uveitis and assayed for local antibody production and the presence of herpesvirus DNA.


RESULTS
Seven cases had mild CSF pleocytosis. In six of seven cases who underwent CSF antibody analysis, we found intrathecal antibody production against herpes simplex virus or varicella-zoster virus which were the causative viruses diagnosed from intraocular fluid in each patients. Polymerase chain reaction (PCR) assay was used to search for virus DNA in the CSF of six patients, but all were negative.


CONCLUSIONS
The results of this study suggest that Kirisawa-Urayama type uveitis is often accompanied with optic nerve involvement and intrathecal antibody production against causative viruses, but we could not find any viral encephalitis.
Department of Ophthalmology, Niigata University School of Medicine, Japan.
Y
Y
Iizuka
T
T
Abe
T
T
Sasagawa
H
H
Abe
D000328:Adult; D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D005260:Female; D006566:Herpesviridae Infections / Q000175:diagnosis; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015882:Retinal Necrosis Syndrome, Acute / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000821:virology; D018139:Simplexvirus / Q000276:immunology; D014605:Uveitis / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral