Anti-inflammatory stent coatings: dexamethasone and related compounds.
The dexamethasone-eluting stent was a well-tolerated and effective means of providing sustained site-specific drug delivery to the porcine coronary artery wall for 28 days, although longer-term biocompatibility of the polymer coating was not assessed. Dexamethasone did not reduce the neointimal hyperplastic response to injury, despite sustained tissue levels of drug.
Park
S H
SH
Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA.
Lincoff
A M
AM
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible; D003327:Coronary Disease / Q000473:pathology / Q000628:therapy; D003331:Coronary Vessels / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D006965:Hyperplasia; D011474:Prosthesis Design; D055502:Secondary Prevention; D015607:Stents; D013552:Swine
D000893:Anti-Inflammatory Agents; D020099:Coated Materials, Biocompatible; D003907:Dexamethasone