Pathologic findings in a steroid-responsive optic nerve infarct in giant-cell arteritis.
OBJECTIVE
To investigate the pathophysiologic mechanism of optic nerve infarction in giant-cell arteritis (GCA).


BACKGROUND
Previous pathologic reports of optic nerve infarction in GCA involved patients who were blind at the time of death. The optic nerve infarcts were primarily retrolaminar in localization. Simultaneous short ciliary and ophthalmic artery vasculitis was found in all patients.


METHODS
Clinical neurologic and ophthalmologic examination, temporal artery biopsy, and neuroimaging tests were performed in a patient with an anterior ischemic optic neuropathy secondary to GCA. Pathologic examination of the viscera, eye, and brain were performed at autopsy 1 month later.


RESULTS
A prelaminar/retrolaminar infarct was found in this patient. Subsiding vasculitis was limited to the short ciliary arteries, sparing the central retinal, pial, and ophthalmic arteries.


CONCLUSIONS
The authors believe that the visual improvement observed in this patient was the result of preserved, anterior optic nerve collateral circulation, as well as the neuroprotective and anti-inflammatory effect of the corticosteroids.
Department of Neurology, University of Illinois College of Medicine at Peoria, 61656-1649, USA. kattahj@uic.edu
J C
JC
Kattah
L
L
Mejico
G A
GA
Chrousos
L E
LE
Zimmerman
H J
HJ
Manz
D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001344:Autopsy; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007238:Infarction / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D008775:Methylprednisolone / Q000627:therapeutic use*; D009900:Optic Nerve / Q000473:pathology* / Q000503:physiopathology; D013699:Temporal Arteries / Q000473:pathology; D014657:Vasculitis / Q000150:complications / Q000473:pathology; D014792:Visual Acuity
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone