Association between hyperhomocysteinaemia and hypertension in Sri Lankans.
This study examined the relationship between homocysteine and its metabolites, and hypertension in a cohort of Sri Lankan patients with essential hypertension. Serum homocysteine, cysteine, cysteinylglycine and glutathione were measured in 86 patients with a diagnosis of essential hypertension and compared with those of an age- and sex-matched control group. Patients with hypertension had significantly higher mean serum concentrations of homocysteine, cysteine and cysteinylglycine. The odds ratio for hypertension for those with a mean serum homocysteine concentration above 18 mumol/l was 2.8. Hyperhomocysteinaemia is a risk factor for hypertension in Sri Lankans and can lead to a threefold increase in risk.
Mendis
S
S
Department of Medicine, Faculty of Medicine, Peradinya, Sri Lanka.
Athauda
S B
SB
Naser
M
M
Takahashi
K
K
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D003545:Cysteine / Q000097:blood*; D004151:Dipeptides / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000453:epidemiology; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013188:Sri Lanka / Q000453:epidemiology
D004151:Dipeptides; D006710:Homocysteine; C028505:cysteinylglycine; D005978:Glutathione; D003545:Cysteine