Cutaneous lymphoma. Understanding the new classification schemes.
Both the REAL and EORTC classification schemes classify lymphomas according to their cell of origin. These schemata also incorporate clinical features that allow for the distinction of some of these disorders. The EORTC classification scheme for primary cutaneous tumors uses terminology similar to that of the REAL classification and should allow for the recognition of teleologically similar tumors in cutaneous and extracutaneous sites. Future investigations will no doubt yield information regarding the true nature of the low-grade B-cell lymphomas of the skin and sort out the ever-increasing number of tumors found to express CD30. Most important, the continued expansion of knowledge regarding cutaneous lymphomas should enhance the ability of physicians to predict prognosis and to arrive at the most effective therapy for patients with these diseases.
Dermatopathology Unit, Harvard Medical School, Massachusetts General Hospital, Boston, USA. duncan@helix.mgh.harvard.edu
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D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000145:classification* / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification* / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000145:classification* / Q000473:pathology