[Extensive eosinophilic pulmonary infiltrates in a depressive patient treated with maprotiline].
A 74 year old man developed progressive dyspnea under treatment with the tetracyclic antidepressant maprotiline for three months. A chest x-ray revealed extended pulmonary infiltrates. Marked eosinophilia of the periperal blood was found (up to 2300/microliter). Rapid clinical and radiological improvement was observed solely by withholding the drug. The eosinophil count retourned to normal within a few weeks. The possible pathogenesis is discussed and the literature reviewed.
Medizinische Klinik, Rätisches Kantons- und Regionalspital, Chur.
R
R
Gaudenz
K
K
Hartmann
W H
WH
Reinhart
M
M
Kuhn
D000368:Aged; D003863:Depression / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000009:adverse effects* / Q000627:therapeutic use*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D011859:Radiography
D008376:Maprotiline
Ausgedehnte eosinophile Lungeninfiltrate unter antidepressiver Behandlung mit Maprotilin.