[Angiogenesis: prognostic marker in prostatic cancer].
Angiogenesis, the formation of new blood vessels, has been suggested to provide important prognostic information in prostate cancer. The aim of this study was to investigate, whether microvessel density (MVD) at diagnosis was correlated with disease-specific survival in a non-curative treated population of prostate cancer patients. MVD was immunohistochemically (factor VIII-related antigen) quantified in archival tumours obtained at diagnosis in 221 prostate cancer patients. The maximal MVD was quantified inside a 0.25 mm2 area of the tumour and the median MVD was 43 (range 16-151). MVD was statistically significantly correlated with clinicopathological characteristics and disease-specific survival. A multivariate analysis demonstrated that MVD was a significant predictor of disease-specific survival in the entire cancer population, as well as in the clinically localized cancer population. These findings suggest that quantitation of angiogenesis reflects the spontaneous clinical outcome of prostate cancer.
Arhus Universitetshospital, Kraeftens Bekaempelse, afdeling for eksperimentel klinisk onkologi.
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M
Borre
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IB
Offersen
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B
Nerstrøm
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J
Overgaard
D000941:Antigens; D014408:Biomarkers, Tumor / Q000032:analysis; D003718:Denmark / Q000453:epidemiology; D005169:Factor VIII / Q000276:immunology; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000276:immunology; D009389:Neovascularization, Pathologic / Q000276:immunology; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000276:immunology / Q000401:mortality
D000941:Antigens; D014408:Biomarkers, Tumor; D005169:Factor VIII
Angiogenese: prognostisk markør ved cancer prostatae.