[In vitro sensitivity of Plasmodium falciparum isolates from Gabon to chloroquine and cycloguanil].
The in vitro susceptibility of 91 Plasmodium falciparum isolates obtained from malaria-infected children living near Libreville (Gabon) was evaluated against chloroquine and cycloguanil (biologically active metabolite of proguanil), using an isotopic micro-drug susceptibility test. In vitro resistance to chloroquine and cycloguanil was observed in 83% (35/42) and in 38% (30/78) of the patients, respectively. Our data showed that 41% (16/39) of Gabonese field isolates were resistant both to chloroquine and cycloguanil. These findings are of great importance because they might indicate imminent chloroquine-proguanil failure, and there are not many affordable antimalarial drugs to replace chloroquine-proguanil combination.
Unité de parasitologie, Institut de médecine tropicale du Service de santé des armées, Marseille, France.
B
B
Pradines
M
M
Mabika Mamfoumbi
A
A
Keundjian
C
C
Lebeau
T
T
Fusai
M
M
Owono Medang
C
C
Rogier
D
D
Parzy
M
M
Kombila
D000293:Adolescent; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005681:Gabon; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D002727:Proguanil; D014227:Triazines / Q000494:pharmacology*
D000962:Antimalarials; D014227:Triazines; C026009:cycloguanil; D002738:Chloroquine; D002727:Proguanil
Sensibilité in vitro d'isolats gabonais de Plasmodium falciparum vis-à-vis de la chloroquine et du cycloguanil.