[Type 2 diabetes mellitus and coronary heart disease].
Coronary artery disease is the most common cause of morbidity and mortality in subjects with type 2 diabetes mellitus. The risk of coronary artery disease, myocardial infarction and mortality from myocardial infarction is markedly increased in type 2 diabetic patients compared with non-diabetics. Diabetic patients with acute myocardial infarction should receive thrombolytic therapy as rapidly as possible and for the same indications as non-diabetics. Diabetic retinopathy is not a contraindication to treatment. The management of diabetic patients should also include medication with aspirin, beta-blockers and ACE-inhibitors. An insulin-glucose infusion during acute myocardial infarction, followed by insulin injections subcutaneously, reduces mortality by about 30% after 12 months and improves long-term prognosis. Thus, insulin-glucose infusion in diabetic patients with acute myocardial infarction, especially in those with a high blood glucose level (> 11 mmol/l), seems advisable. Diabetic patients benefit from secondary prevention by drug therapy (aspirin, lipid lowering with statins, beta-blockers and ACE-inhibitors) to the same extent as, or more than, non-diabetic patients.
Abteilung für Endokrinologie/Diabetologie, Universitätsspital Zürich. ndobraem@usz.unizh.ch
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Brändle
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Amann
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Salomon
D002423:Cause of Death; D003327:Coronary Disease / Q000401:mortality* / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality* / Q000517:prevention & control; D003925:Diabetic Angiopathies / Q000401:mortality* / Q000517:prevention & control; D006801:Humans; D009203:Myocardial Infarction / Q000401:mortality* / Q000517:prevention & control; D011379:Prognosis; D012307:Risk Factors
Diabetes mellitus Typ 2 und koronare Herzkrankheit.