Outcome of surgical versus medical treatment of dogs with beta cell neoplasia: 39 cases (1990-1997).
OBJECTIVE
To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia.


METHODS
Retrospective study.


METHODS
39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia.


METHODS
Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records.


RESULTS
26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (i.e., dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs.


CONCLUSIONS
Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs.
Tobin
R L
RL
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
Nelson
R W
RW
Lucroy
M D
MD
Wooldridge
J D
JD
Feldman
E C
EC
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D004032:Diet / Q000662:veterinary; D004283:Dog Diseases / Q000178:diet therapy / Q000188:drug therapy / Q000601:surgery*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000178:diet therapy / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D008297:Male; D010180:Pancreatectomy / Q000662:veterinary; D010190:Pancreatic Neoplasms / Q000178:diet therapy / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D001786:Blood Glucose; D007328:Insulin; D011241:Prednisone