Cu(III)-polypeptide complexes exhibiting SOD-like activity.
The SOD-like activity of Cu(III)-complexes with polypeptides poly-L-lysine and poly-L-glutamic acid respectively was investigated. The Cu(II)-polypeptide complexes were first oxidized by K2IrCl6 to give the corresponding Cu(III)-compounds. The oxidation of Cu(II) and the corresponding Cu(II)/Cu(III) potential was evaluated by cyclic voltammetry (c.v.), UV-Vis and EPR spectroscopic (r.t.) experiments. Spin trapping EPR spectra were also conducted to confirm the formation of the superoxide radical. The SOD-like activity of each Cu(III)-complex was proved using the nitro blue tetrazolium (NBT) method slightly modified.
Laboratory of Organic Chemistry, Aristotle University of Thessaloniki, Greece.
M
M
Liakopoulou-Kyriakides
S
S
Hadjispyrou
A
A
Zarkadis
D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D011099:Polyglutamic Acid / Q000737:chemistry / Q000378:metabolism; D011107:Polylysine / Q000737:chemistry / Q000378:metabolism; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000378:metabolism; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism
D016166:Free Radical Scavengers; D010455:Peptides; D013481:Superoxides; D011107:Polylysine; D011099:Polyglutamic Acid; D003300:Copper; D013482:Superoxide Dismutase