Deletion of Y chromosome involving the DAZ (deleted in azoospermia) gene in XX males.
The testicular histology and the presence or absence of 32 Y DNA loci was investigated, with a focus on the long arm of Y chromosome (Yq) interval 6, by means of a polymerase chain reaction strategy in 2 XX males. Seminiferous tubules lined by only Sertoli cells and a slight thickening of tubular walls were observed. The men showed an absence of 32 Y DNA loci. These facts suggest that severe spermatogenic impairment is caused by deletions of Yq interval 6 in XX males.
Department of Urology, Yamagata University School of Medicine, Japan.
T
T
Tateno
I
I
Sasagawa
J
J
Ashida
T
T
Nakada
D000328:Adult; D002872:Chromosome Deletion; D000075364:Deleted in Azoospermia 1 Protein; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D016601:RNA-Binding Proteins / Q000235:genetics*; D012671:Seminiferous Tubules / Q000473:pathology; D012729:Sex Chromosome Aberrations / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D014960:X Chromosome; D014998:Y Chromosome
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D016601:RNA-Binding Proteins