Congenital CD34-positive granular cell dendrocytosis.
Granular cell tumors involving the skin are mostly acquired lesions. The Schwann cell origin of these lesions is supported by positive immunostaining for S-100 protein and myelin basic protein. S-100- granular cell lesions rarely have been described in association with fibrous papules or dermatofibromas. The congenital variety of S-100- granular cell tumors occurs almost exclusively in the gingiva. The cell origin of these lesions is not well delineated. We report a hitherto undescribed case of a congenital cutaneous lesion which is histologically characterized by diffuse dermal infiltrates of S-100- but CD34+ granular dermal dendrocytes. The granular appearance of these CD34+ dendrocytes is attributed to an abundance of phagolysosomes. The pathogenetic mechanism of this unusual lesion remains to be elucidated.
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
S E
SE
Chang
J H
JH
Choi
K J
KJ
Sung
K C
KC
Moon
J K
JK
Koh
S D
SD
Lim
J
J
Huh
T
T
Shwayder
M W
MW
Lee
D018952:Antigens, CD34 / Q000378:metabolism*; D001706:Biopsy; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D003713:Dendritic Cells / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D016586:Granular Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D010588:Phagosomes / Q000473:pathology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure
D018952:Antigens, CD34