A case of trisomy 22 in a live hereford calf.
A case of the rare genetic trisomy 22 in a live calf is described. The calf had low blood thyroxine level and low growth rate. It had several defects including brachygnathia superior, strabismus convergence, aortal cusp insufficiency and hypertrophy of clitoris. Chromosome analysis was performed on cultured blood lymphocytes and fibroblast cells. In all counted metaphases 61 chromosomes were present. The extra chromosome was identified as a chromosome 22 by R-banding. The defects of the calf have similarities with cases of partial trisomy 3p25-pter in human. This section of the human chromosome 3 corresponds to sections of cattle chromosome 22.
Department of Animal Science and Animal Health, Royal Veterinary and Agricultural University, Frederiksberg, Denmark. kc@kvl.dk
K
K
Christensen
L
L
Juul
D000818:Animals; D001011:Aorta / Q000002:abnormalities; D002417:Cattle / Q000002:abnormalities* / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding / Q000662:veterinary; D002987:Clitoris / Q000002:abnormalities; D004948:Esotropia / Q000235:genetics / Q000662:veterinary; D005260:Female; D013974:Thyroxine / Q000097:blood; D014314:Trisomy / Q000235:genetics*
D013974:Thyroxine