Action of antidepressant drugs on maternal stress-induced hypoactivity in female rats.
It has been reported that rats forced to swim in a restricted space assume, after initial frenzied attempts to escape, an immobile posture. Porsolt et al. referred to this phenomenon as "behavioral despair", an animal model of depression. Prenatal stress induces an increase of behavioral depression in adult female offspring. This study presents new evidence supporting the hypothesis that maternal stress during gestation increases the risk of depression in the offspring since immobility time was modified by antidepressant drugs (tricyclics and an atypical antidepressant). In rats, amitriptyline (5 mg/kg), imipramine (5 mg/kg) and nomifensine (1 mg/kg) decreased the immobility time in Porsolt test in offspring of mothers stressed during gestation. Moreover, increasing doses of amitriptyline (1, 5, 25 and 40 mg/kg) reduced depression in the forced swimming test in dose-dependent manner.
Alonso
S J
SJ
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Castellano
M A
MA
Quintero
M
M
Navarro
E
E
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D005260:Female; D007099:Imipramine / Q000494:pharmacology; D009627:Nomifensine / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D009627:Nomifensine; D007099:Imipramine