[In vitro study of regulation of rat liver xanthine oxidase activity by antioxidant reducing agents].
It was learned the regulation of xanthine oxidase activity from rat liver in the partly purified prepared by ascorbic acid, glutathione-SH, dithiothreitol, cysteine++ and hydrocortisone++. It was shown that ascorbic acid glutathione-SH, dithiothreitol, and cysteine++ can be activators and uncompetitor inhibitors of xanthine oxidase in dependence from concentration. As far as hydrocortisone is concerned, it is a powerful uncompetitor inhibitor of xanthine oxidase, that is bind with it. It was considered the mechanism of activation and inhibition of xanthine oxidase by these reductors-antioxidants.
I.I. Mechnikov Odessa State University.
V V
VV
Sumbaev
A Ia
AIa
Rozanov
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D019163:Reducing Agents / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000975:Antioxidants; D004791:Enzyme Inhibitors; D019163:Reducing Agents; D014969:Xanthine Oxidase
Issledovanie in vitro reguliatsii aktivnosti ksantinoksidazy pecheni krys vosstanoviteliami-antioksidantami.