Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins.
Macek
T A
TA
Program in Molecular Therapeutics and Toxicology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. tmacek@emory.edu
Schaffhauser
H
H
Conn
P J
PJ
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D004095:Dihydropyridines / Q000494:pharmacology; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism*; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006624:Hippocampus / Q000201:enzymology* / Q000378:metabolism; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D010704:Phorbols / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D043684:Receptor, Adenosine A3; D018094:Receptors, Metabotropic Glutamate / Q000145:classification / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
C114785:2-amino-4-phosphono-propinate; D004095:Dihydropyridines; C107728:MRS 1191; D010704:Phorbols; D011422:Propionates; D043684:Receptor, Adenosine A3; D018094:Receptors, Metabotropic Glutamate; D018047:Receptors, Purinergic P1; D015240:Phorbol 12,13-Dibutyrate; D016244:Guanosine 5'-O-(3-Thiotriphosphate); D011493:Protein Kinase C; D019204:GTP-Binding Proteins; D000241:Adenosine; C033085:phorbol; C090034:2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide