Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis.
Although Epstein-Barr virus (EBV) has been reported to be present in some 7% of gastric carcinomas, the nature of the background gastric mucosa of carcinoma has not been elucidated. The authors evaluated the degree of gastritis in the background gastric mucosa of EBV-associated gastric carcinoma. EBV was detected using in situ hybridization for EBV-encoded small ribonucleic acid 1 (EBER-1) in carcinoma cells. The authors compared gastritis in surgically resected stomachs with 8 EBER-1-positive and 16 EBER-1-negative gastric carcinomas of a similar histologic type using histologic variables of the Updated Sydney System. All eight lesions of EBER-1-positive gastric carcinomas had intestinal metaplasia in the background. Mild to moderate glandular atrophy was common in both groups. Many of the tested lesions, 87.5% of EBER-1-positive and 62.5% of EBER-1-negative lesions, were located near the mucosal atrophic border. The background gastric mucosa for EBV-associated gastric carcinomas is rich in atrophic changes. EBV-associated gastric carcinomas are located near the mucosal atrophic border.
First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.
H
H
Yanai
T
T
Murakami
H
H
Yoshiyama
H
H
Takeuchi
J
J
Nishikawa
H
H
Nakamura
K
K
Okita
O
O
Miura
N
N
Shimizu
K
K
Takada
D005753:Gastric Mucosa / Q000473:pathology / Q000821:virology; D005757:Gastritis, Atrophic / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D012367:RNA, Viral / Q000302:isolation & purification*; D013274:Stomach Neoplasms / Q000473:pathology / Q000821:virology*
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral