Influence of combined zero-balanced and modified ultrafiltration on the systemic inflammatory response during coronary artery bypass grafting.
OBJECTIVE
To evaluate whether combined zero-balanced and modified ultrafiltration affects the systemic inflammatory response in coronary artery bypass graft (CABG) patients.


METHODS
Randomized and controlled.


METHODS
University-affiliated heart center.


METHODS
Forty-three patients scheduled for elective CABG.


METHODS
In the ultrafiltration group (UF group; n = 21), zero-balanced ultrafiltration was performed during rewarming and modified ultrafiltration immediately after the end of cardiopulmonary bypass (CPB). A control group of patients (n = 22) was treated identically to the treatment group except no ultrafiltration process was performed.


RESULTS
Immediately after CPB (ie, after zero-balanced ultrafiltration), and again after the modified ultrafiltration, the concentrations of interleukin-6 and interleukin-8 were significantly less (p < 0.05) in the UF group compared with the control group. Both proinflammatory cytokine levels peaked at 2 and 4 hours after CPB, at which time no difference between the two groups could be observed. The levels of measured anti-inflammatory mediators (interleukin-10 and interleukin-1 receptor antagonist) did not show any difference between the two groups. Intrapulmonary shunt fraction decreased in the course of the modified ultrafiltration from 31% +/- 1.2% to 25% +/- 1.3% (p < 0.01), whereas mean arterial pressure increased (69 +/- 1.8 to 80 +/- 2.8 mmHg; p < 0.01); neither parameter changed in the control group. Time to extubation was shorter in the UF group (6.1 +/- 0.5 v 8.6 +/- 0.7 hours; p < 0.05).


CONCLUSIONS
It was concluded that the use of ultrafiltration diminished inflammatory response in a very limited time period immediately after CPB and, probably as a consequence, slightly improved clinical parameters.
Institute of Anesthesiology, Department of Cardiac Surgery, German Heart Center Munich at the Technical University, München.
P
P
Tassani
J A
JA
Richter
G P
GP
Eising
A
A
Barankay
S L
SL
Braun
C H
CH
Haehnel
P
P
Spaeth
H
H
Schad
H
H
Meisner
D001794:Blood Pressure; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006339:Heart Rate; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D018746:Systemic Inflammatory Response Syndrome / Q000517:prevention & control*
D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10