Detection of hepatitis C virus RNA in the hearts of patients with hepatogenic cardiomyopathy.
We examined the Hepatitis C virus (HCV) genome in the myocardium and liver obtained at autopsy from seven patients with HCV-positive liver cirrhosis and hepatocellular carcinoma (HCC) by in situ hybridization and histopathological studies. The HCV virus genome was detected in the myocardium of one patient as well as in the liver in three out of seven patients. However, Epstein-Barr (EB) virus genome could not be detected in liver or myocardium. In the patient who showed positive reaction to HCV in myocardium, both serum HCV and Hepatitis B virus (HBV) antibodies were positive. It is unknown whether this was related to an immunological abnormality of the host or to an interaction between RNA and DNA viruses. In conclusion, we could identify the HCV genome in the myocardium of a patient with hepatogenic myocardosis.
Department of Internal Medicine, Aoto Hospital, Jikei University, Tokyo, Japan.
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Takeda
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Sakata
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Takeda
D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000821:virology; D009202:Cardiomyopathies / Q000473:pathology / Q000821:virology*; D005260:Female; D006321:Heart / Q000821:virology; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification*; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology; D006801:Humans; D017403:In Situ Hybridization; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology*; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry* / Q000473:pathology; D015345:Oligonucleotide Probes; D015347:RNA Probes; D012367:RNA, Viral / Q000032:analysis*
D000914:Antibodies, Viral; D015345:Oligonucleotide Probes; D015347:RNA Probes; D012367:RNA, Viral