Airway patterning: A paradigm for restricted signalling.
Intercellular signalling is limited by the range of cell responsiveness, often mediated by repressors. A recently identified repressor, Sprouty, inhibits MAP kinase signalling in flies, mice and humans and has a conserved function in patterning the airways of these divergent species.
Developmental Genetics Programme, Krebs Institute, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
M
M
Placzek
H
H
Skaer
D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins; D004815:Epidermal Growth Factor / Q000235:genetics / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000502:physiology*; D008168:Lung / Q000196:embryology; D020935:MAP Kinase Signaling System; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D015398:Signal Transduction; D014132:Trachea / Q000378:metabolism* / Q000502:physiology*
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; C110486:sty protein, Drosophila; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor