[Novel chiroptical methods in pharmaceutical analysis].
Chiroptical spectroscopy, and its double and triple hyphenated combinations with UV-VIS spectroscopy and/or separation techniques constitute great progress in pharmaceutical analysis, of which five recently developed methods are surveyed here, as follows: The determination of enantiomeric purity by double, CD/UV detection without, and with the latter one provides enhanced sensitivity and selectivity. The determination of chromatographic peak homogeneity, by double detection, and peak slicing by recording. The separation, identification and four stereoisomers of doubly chiral compounds, by HPLC separation on chiral column, and optical-chiroptical detection.
SOTE Gyógyszerészi Kémiai Intézet, Budapest.
A
A
Gergely
H
H
Hegedús
P
P
Horváth
B
B
Noszál
G
G
Szász
F
F
Zsila
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002942:Circular Dichroism; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010604:Pharmacy / Q000379:methods; D013053:Spectrophotometry / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations
Ujabb kiroptikai módszerek a gyógyszeranalízisben.