Sequence and expression of a cDNA encoding the red seabream androgen receptor.
The cDNA of the androgen receptor (AR) has been isolated from the ovary of red seabream, Pagrus major, and sequenced. The amino acid sequence of red seabream AR (rsAR) shows about 45% identity with those of Xenopus, rat, mouse, and human ARS. It is shown that rsAR has the ability to trans-activate the responsive gene depending on the presence of androgen.
Touhata
K
K
Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.
Kinoshita
M
M
Tokuda
Y
Y
Toyohara
H
H
Sakaguchi
M
M
Yokoyama
Y
Y
Yamashita
S
S
D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D015870:Gene Expression; D008969:Molecular Sequence Data; D010473:Perciformes / Q000235:genetics*; D011944:Receptors, Androgen / Q000096:biosynthesis / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D015534:Trans-Activators / Q000235:genetics; D014162:Transfection
D018076:DNA, Complementary; D011944:Receptors, Androgen; D015534:Trans-Activators; D013739:Testosterone; C003600:11-ketotestosterone