Molecular modelling of the 5-hydroxytryptamine receptors.
Molecular models of the 5-hydroxytryptamine receptors are reviewed with particular emphasis upon ligand receptor interactions. The use of such models in the areas of drug design and the design and rationalisation of experiments is discussed. It is clear that many groups have modelled the 5-HT receptors using either the bacteriorhodopsin structure, rhodopsin electron density map or rhodopsin alpha-carbon template. Although it is difficult to assess the accuracy of these models it is expected that the rhodopsin based models show improved accuracy over the bacteriorhodopsin based models. Nevertheless models that are thoroughly validated with experimental mutagenesis and ligand binding data are useful in a qualitative sense providing ideas upon target compounds to synthesise and the design and rationalisation of mutagenesis experiments.
Wolfson Institute for Biomedical Research, University College London, UK. g.wishart@uc1.ac.uk
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G
Wishart
D H
DH
Bremner
K R
KR
Sturrock
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001436:Bacteriorhodopsins / Q000737:chemistry; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D011485:Protein Binding; D011487:Protein Conformation; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000145:classification / Q000187:drug effects / Q000502:physiology; D012243:Rhodopsin / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012701:Serotonin / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D001436:Bacteriorhodopsins; D019204:GTP-Binding Proteins; D011985:Receptors, Serotonin; D012243:Rhodopsin; D012701:Serotonin; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors