Free radicals and reactive oxygen species in programmed cell death.
Oxidative stress, originating from reactive oxygen species and free radicals provides a constant challenge to eukaryotic cell survival. While implicated in a number of degenerative diseases, some associated with aging and with aging itself, the manner and extent to which oxidative stress contributes to the initiation or implementation of programmed-cell death is problematic. If oxidative stress is an important modulator of programmed-cell death, any ability intentionally to augment or inhibit it might ameliorate diseases in which the process is abnormally underactive or overactive.
Department of Medicine, Rush Presbyterian St Luke's Medical Center, Chicago, IL 60612, USA.
K M
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Anderson
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Seed
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Ou
J E
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Harris
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D002908:Chronic Disease; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000502:physiology*
D005609:Free Radicals; D017382:Reactive Oxygen Species