Comparison of morphine patient-controlled analgesia with and without ketorolac for postoperative analgesia in pediatric orthopedic surgery.
The purpose of this prospective, randomized, double-blind, placebo-controlled clinical study was to determine whether the administration of intravenous ketorolac, coadministered with morphine patient-controlled analgesia (PCA), demonstrates an opioid-sparing effect, provides improved analgesia, and reduces the incidence of opioid-induced side effects in children after orthopedic surgery. The findings of enhanced analgesia with decreased opioid use suggest that coadministration of ketorolac with morphine PCA is beneficial for the treatment of pain in children after orthopedic surgery.
Sutters
K A
KA
Surgical Services, Valley Children's Hospital, Madera, California, USA.
Shaw
B A
BA
Gerardi
J A
JA
Hebert
D
D
D000293:Adolescent; D016058:Analgesia, Patient-Controlled; D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020910:Ketorolac; D008297:Male; D009020:Morphine; D019637:Orthopedic Procedures; D010149:Postoperative Pain / Q000517:prevention & control*; D011446:Prospective Studies; D014046:Tolmetin / Q000031:analogs & derivatives*
D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D009020:Morphine; D014046:Tolmetin; D020910:Ketorolac