Dynamics of placodal lineage development revealed by targeted transgene expression.
Examination of the expression pattern of the winged-helix transcription factor BF-1 outside of the neural tube in mouse embryos suggests that BF-1 is restricted to a population of cells that gives rise to the ectodermal placodes and their derivatives. Within the sensory cranial nerve ganglia, the expression of BF-1 distinguishes cells that arise from the placodes from those derived from the neural crest. Expression of a lacZ transgene targeted to the BF-1 locus was used to follow the placodal lineage during mouse development. Analysis of placodal development in mice with a targeted deletion of BF-1 reveals that, although BF-1 is required for proliferation of the cells arising from the nasal placode, it is not required for the proliferation, survival, or both, of placode-derived cells in the sensory cranial nerve ganglia. Dev Dyn 1999;215:332-343.
Cell Biology Program, Sloan-Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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D000818:Animals; D019070:Cell Lineage; D002465:Cell Movement; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D051767:Early Growth Response Protein 2; D004475:Ectoderm / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000294:innervation; D004625:Embryo, Nonmammalian / Q000294:innervation; D051858:Forkhead Transcription Factors; D017950:Ganglia, Sensory / Q000033:anatomy & histology / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; D051767:Early Growth Response Protein 2; C497327:Egr2 protein, mouse; D051858:Forkhead Transcription Factors; C489562:Foxd1 protein, mouse; D009419:Nerve Tissue Proteins; D014157:Transcription Factors