Hypersensitivity reaction to carboplatin. Results of skin tests.
Four patients with hypersensitivity reaction to carboplatin of variable severity, after previous uneventful cisplatin and carboplatin treatment, are described. Skin testing performed in two of the patients suggests a cross-reaction with cisplatin but was negative with carboplatin in one of them. The mechanism of hypersensitivity reaction to carboplatin is poorly understood and the issue of retreatment with carboplatin is controversial. Physicians should be aware of the possible hypersensitivity reaction to carboplatin and appropriate precautions should be taken.
Department of Obstetrics and Gynecology, E. Wolfson Medical Center, Holon, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
J
J
Menczer
G
G
Barda
M
M
Glezerman
H
H
Hyat
Y
Y
Brenner
C M
CM
Brickman
A
A
Tanai
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012882:Skin Tests
D000970:Antineoplastic Agents; D016190:Carboplatin