[The role of chronic colitis in the pathogenesis of Hirschsprung 's disease in children].
The role of chronic colitis in pathogenesis of Hirschsprung's disease was studied ultrastructurally and morphometrically. Morphological features of chronic colitis were revealed by examination of full-layers biopsies and excised fragments of the colon in 26 children aged from 2 to 14 years with Hirschsprung's disease. Atrophic-sclerotic form of colitis develops in various disturbances of colo-rectal innervation. In this condition diffuse sclerosis of bowel wall could be considered as pathognomonic symptom of Hirschsprung's disease. As a result of development of sclerosis insufficiency of the bowel motor function increases.
P I
PI
Kolomeĭtsev
E M
EM
Malkova
V V
VV
Omigov
S V
SV
Matveeva
P V
PV
Tereshchenko
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003082:Colectomy; D003092:Colitis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003106:Colon / Q000473:pathology; D004760:Enterocolitis / Q000150:complications / Q000473:pathology / Q000601:surgery; D006627:Hirschsprung Disease / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D012007:Rectum / Q000473:pathology
Rol' khronicheskogo kolita v patogeneze bolezni Girshprunga u deteĭ.