Fixed drug eruption in hands caused by omeprazole.
OBJECTIVE
Omeprazole is one of the most widely prescribed gastric antisecretory drugs. It is generally well tolerated and significant adverse reactions occur rarely. The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.


METHODS
A 37-year-old white female patient admitted with epigastric pain and heartburn symptoms. An upper gastrointestinal endoscopy revealed reflux esophagitis and the patient was given 20 mg b.i.d. omeprazole. She developed dark-red coloration on her hands, at the fourth day of treatment, which has been defined as fixed drug eruption. These lesions were attributed to treatment and recurred soon after a rechallenge with omeprazole.


CONCLUSIONS
Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole. We suggest being aware of such reactions during omeprazole usage.
Department of Internal Medicine, Medical Faculty, Gaziantep University, Turkey.
Y
Y
Kepekci
A
A
Kadayifci
D000328:Adult; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D009853:Omeprazole / Q000009:adverse effects* / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D009853:Omeprazole