[Studying intestinal maturation in newborn infants by means of stable isotopes].
Survival and subsequent quality of life in low birth weight infants are related to an adequate early nutrition. Premature children require parenteral nutrition support in the first days of life due to their intolerance enteral nutrition. In experimental studies, parenteral nutrition promotes intestinal abnormalities. Minimal enteral feeding has been proposed to minimise these adverse effects. Stable isotopes technology is an adequate tool to investigate metabolism in the perinatal period. The amino acid Leucine has been used by different authors for the study of protein turnover. The double tracer technology allows to follow the seizure of an amino acid administered enterally in splanchnic tissue. By continuous infusion and breath tests we can estimate protein synthesis in these children.
Servicio de Neonatología, Hospital Infantil La Paz, Madrid.
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D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes / Q000032:analysis*; D002986:Clinical Trials as Topic; D003903:Deuterium / Q000032:analysis; D004044:Dietary Proteins / Q000493:pharmacokinetics*; D004750:Enteral Nutrition; D005325:Fetal Organ Maturity; D005998:Glycine; D006801:Humans; D007225:Infant Food; D007230:Infant, Low Birth Weight / Q000378:metabolism*; D007231:Infant, Newborn; D007422:Intestines / Q000254:growth & development*; D007930:Leucine / Q000008:administration & dosage; D008895:Milk, Human / Q000378:metabolism; D009587:Nitrogen Isotopes / Q000032:analysis*; D010288:Parenteral Nutrition / Q000009:adverse effects; D011506:Proteins / Q000378:metabolism*; D014508:Urea / Q000032:analysis
D002247:Carbon Isotopes; D004044:Dietary Proteins; D009587:Nitrogen Isotopes; D011506:Proteins; D002245:Carbon Dioxide; D014508:Urea; D003903:Deuterium; D007930:Leucine; D005998:Glycine
Estudio de la maduración intestinal en neonatos con isótopos estables.