A role for AMPA/kainate receptors in conditioned place preference induced by diazepam in the rat.
There is increasing evidence for a role of glutamate receptors in the reinforcing properties of dependence producing drugs such as the psychostimulants and opiates. Activation of AMPA/kainate receptors are implicated in the acquisition of amphetamine-induced reinforcement but a role for this receptor in benzodiazepine-induced reinforcement has not been examined. In the present study the ability of the orally active AMPA/kainate antagonist GYKI 52466 was assessed for its ability to block the reinforcing properties of diazepam in a conditioned place preference paradigm. Diazepam (2.5 and 5.0 mg/kg, i.p.) produced a robust place preference and GYKI 52466 inhibited the acquisition of place preference conditioning-induced by diazepam. These results suggest that glutamatergic pathways are an important component of the circuitry involved in the acquisition of a benzodiazepine induced place preference.
Department of Physiology and Pharmacology, University of Strathclyde, Strathclyde Institute of Biomedical Sciences, Glasgow, UK.
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Gray
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Allison
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Pratt
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D003213:Conditioning, Psychological / Q000187:drug effects*; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018757:GABA Modulators / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000502:physiology*; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors / Q000502:physiology*; D012201:Reward
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003975:Diazepam; D018757:GABA Modulators; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; C061950:GYKI 52466