Intra-periaqueductal grey injection of galanin increases the nociceptive response latency in rats, an effect reversed by naloxone.
The nociceptive response latencies were increased significantly after intra-periaqueductal grey (PAG) administration of 1.0 or 3.0 nmol of galanin, but not 0.3 nmol, in rats. The effect of galanin was attenuated by following injection of 5.5 nmol of naloxone into PAG. These results indicate an anti-nociceptive role of galanin, and a possible interaction between galanin and opioid peptides in PAG in rats.
Department of Physiology, College of Life Sciences, Peking University, Beijing 100871, China.
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Wang
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Ye
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Yu
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Lundeberg
D000818:Animals; D019004:Galanin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology*; D010487:Periaqueductal Gray / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects
D009292:Narcotic Antagonists; D009270:Naloxone; D019004:Galanin