The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts.
Chemokines are low molecular weight secretory proteins that function principally as stimulators of leukocyte recruitment. There are four defined chemokine subfamilies based on their primary structure, CXC, CC, C and CX3C. Members of the CC chemokine subfamily, a such as monocyte chemoattractant protein 1 (MCP-1) are chemotactic for monocytes and other leukocyte subsets. Because monocytes produce factors that regulate bone formation or resorption, such as PDGF, IL-1 or TNF, chemokines that initiate their recruitment are likely to be important in regulating osseous metabolism. In the studies below, data is presented demonstrating mechanisms of MCP-1 expression in osteoblastic cells. These studies establish that MCP-1 is induced during osseous inflammation and in developmentally regulated bone remodelling, and is associated with enhanced monocyte recruitment when applied to osseous lesions.
Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA 02118, USA. dgraves@acs.bu.edu
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DT
Graves
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Jiang
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Valente
D000818:Animals; D001483:Base Sequence; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D018925:Chemokines / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016023:Integrins / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000378:metabolism
D018932:Chemokine CCL2; D018925:Chemokines; D016023:Integrins