MR colonography: optimized enema composition.
Manganese chloride, iron glycerophosphate, and cellulose additive were assessed as base materials for use in a T1-shortening single contrast enema for magnetic resonance (MR) colonography. Contrast-to-noise ratios (CNRs) were compared to those with the standard 10 mmol/L gadolinium-based enema. On T1-weighted three-dimensional gradient-recalled-echo images, CNRs with the iron glycerophosphate enema exceeded those with the manganese- and gadolinium-based enemas. Use of an additive of 0.8% wt/wt cellulose was found to be practicable as it increased viscosity sufficiently without altering CNR. The gadolinium-based enema can be replaced with an iron glycerophosphate enema to render MR colonography less costly.
Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland.
W
W
Luboldt
J M
JM
Frohlich
N
N
Schneider
D
D
Weishaupt
F
F
Landolt
J F
JF
Debatin
D000328:Adult; D000368:Aged; D000818:Animals; D016477:Artifacts; D002482:Cellulose; D002712:Chlorides; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003287:Contrast Media; D004357:Drug Synergism; D004733:Enema; D005260:Female; D019786:Gadolinium DTPA; D005994:Glycerophosphates; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007501:Iron; D008279:Magnetic Resonance Imaging; D008297:Male; D017895:Manganese Compounds; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013552:Swine; D014783:Viscosity
D002712:Chlorides; D003287:Contrast Media; D005994:Glycerophosphates; D017895:Manganese Compounds; D002482:Cellulose; D007501:Iron; D019786:Gadolinium DTPA; C025340:manganese chloride