Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems.
Alagarsamy
S
S
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Rouse
S T
ST
Gereau
R W
RW
Heinemann
S F
SF
Smith
Y
Y
Conn
P J
PJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D004594:Electrophysiology; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000494:pharmacology; D016202:N-Methylaspartate / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D009865:Oocytes / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D018092:Kainic Acid Receptors / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics; D014981:Xenopus
D003515:Cycloleucine; D008734:Methoxyhydroxyphenylglycol; D016202:N-Methylaspartate; D018696:Neuroprotective Agents; D010749:Phosphoprotein Phosphatases; D018092:Kainic Acid Receptors; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; C036361:1-amino-1,3-dicarboxycyclopentane; C010117:3,4-dihydroxyphenylglycol