Inhibition of aromatase activity by flavonoids.
In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).
Jeong
H J
HJ
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA. hyehjean@nmdhst.cc.nih.gov
Shin
Y G
YG
Kim
I H
IH
Pezzuto
J M
JM
D001141:Aromatase / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008861:Microsomes / Q000201:enzymology*; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013997:Time Factors
D005419:Flavonoids; D001141:Aromatase