Radiosynthesis of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta (4' methylphenyl) nortropane (FPCMT).
A synthetic procedure for the routine preparation of [18F] N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4' methylphenyl) nortropane (18F FPCMT) has been developed. The synthesis is based on alkylation of nortropane with 18F labeled fluoropropyl tosylate. Purification of the final product was achieved by a preparative HPLC procedure using Alltech Econosil column. Separation of the desired compound was achieved and the product was clean. The radiochemical yield (without decay correction) is 4 to 5%, calculated at the end of the synthesis based on the total amount of fluorine recovered from the target. Radiochemical purity was in the range of 98 to 99%.
Chaly
T
T
Department of Research, North Shore University Hospital, NYU Medical College, Manhasset 11030, USA.
Matacchieri
R
R
Dahl
R
R
Dhawan
V
V
Eidelberg
D
D
D002851:Chromatography, High Pressure Liquid; D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D015394:Molecular Structure; D009662:Nortropanes / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; C120346:N-3-fluoropropyl-2-carbomethoxy-3-(4'-methylphenyl)nortropane; D009662:Nortropanes; D019275:Radiopharmaceuticals