Diffuse central nervous system lupus involving white matter, basal ganglia, thalami and brainstem.
We described an 11-year-old girl with acute central nervous system lupus showing diffuse lesions. She developed generalized convulsions followed by prolonged coma, and her psychomotor ability recovered fully after 3 months of steroid therapy. Cranial magnetic resonance imaging (MRI) showed high signal intensity in the cerebral deep white matter, bilateral basal ganglia, thalami, and brainstem on T2-weighted image. These lesions resolved over 1 month with residual atrophic change in the heads of the caudate nucleus on MRI. Acute SLE leukoencephalopathy may be recognized as a subtype of CNS lupus.
Department of Pediatric, Nagoya City University Medical School, Nagoya, Japan.
M
M
Shibata
T
T
Kibe
S
S
Fujimoto
T
T
Ishikawa
M
M
Murakami
T
T
Ichiki
Y
Y
Wada
D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology*; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology*; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D013788:Thalamus / Q000000981:diagnostic imaging / Q000473:pathology*; D015899:Tomography, Emission-Computed, Single-Photon