[Transcutaneous radiotherapy after thyroidectomy for differentiated thyroid carcinoma].
OBJECTIVE
To compare the results, in terms of 10-year actuarial survival, between I-131-therapy and I-131-therapy + external beam radiotherapy (RT) in patients operated on for differentiated thyroid carcinoma.


METHODS
Over a period of 13 years (1982-1995) 408 patients underwent thyroidectomy with or without linphoadenectomy for pT0/T4 Nx or pN0, pN1a, pN1b thyroid carcinoma. In all cases, thyroidectomy was radical. Patients were divided into two groups, which were comparable according to several prognostic factors: group A composed of 165 patients (surgery + I-131) and group B, 243 patients (surgery + I-131 + RT).


RESULTS
The percentage of deaths related to relapsed or metastatic thyroid carcinoma was 6.25%. In the group treated with adjuvant radiotherapy, 14.8% of the patients experienced acute tracheal or esophageal side effects. Late toxicity (mouth dryness, skin and/or muscle fibrosis) was recorded only in a small percentage of the patients (2.4%).


CONCLUSIONS
Adjuvant RT resulted in a statistically significant improvement (p < 0.01) in survival of patients with extracapsular diffusion of the cancer, especially those with pT4 N1b tumors or tumors involving the trachea.
Radioterapia Azienda Ospedaliera Sant' Orsola-Malpighi, Bologna, Italia.
L
L
Busutti
A B
AB
Blotta
G
G
Calò-Gabrieli
L
L
dell'Erba
D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D002454:Cell Differentiation; D006801:Humans; D009362:Neoplasm Metastasis; D011182:Postoperative Care; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome
La radioterapia transcutanea dopo tiroidectomia per carcinoma tiroideo differenziato.