Hepatitis E virus -- an update.
Hepatitis E virus (HEV) is the principal cause of enterically-transmitted, non-A, non-B hepatitis and has been associated with excess mortality in pregnant women infected during epidemics. Molecular cloning of the viral genome led to the development of diagnostic tests, including enzyme immunoassays for antibody and RT-PCR for viral RNA. Candidate vaccines have not yet reached clinical trials. The virus resembles caliciviruses, with a positive sense RNA genome encoding three open reading frames. The geographical distribution of the virus, which may infect domestic animals as well as humans, may be wider than thought originally.
Royal Free and University College Medical School, University College London, UK.
T J
TJ
Harrison
D000818:Animals; D005260:Female; D000882:Haplorhini; D016751:Hepatitis E / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control / Q000635:transmission*; D016752:Hepatitis E virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000401:mortality; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012756:Sheep; D013552:Swine; D014614:Vaccines, Synthetic / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D014614:Vaccines, Synthetic; D014764:Viral Proteins