Technique for heterotopic pig heart xenotransplantation in primates.
The primate is a commonly utilized model for the human immune response after heart transplantation. This report describes our experience with heterotopic abdominal transplantation of porcine hearts into primate recipients. Abdominal graft placement was surprisingly well tolerated, and we found this approach to be particularly useful in the setting of significant donor-recipient size mismatch. Continuous monitoring with an implantable monitoring system facilitated assessment of graft viability in awake recipients; progressive graft bradycardia and decreasing QRS amplitude were predictive of ensuing graft failure.
Primate Xenotransplantation Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. dhadams@bics.bwh.harvard.edu
D H
DH
Adams
R H
RH
Chen
A
A
Kadner
S
S
Naficy
D000005:Abdomen; D000818:Animals; D006085:Graft Survival; D016027:Heart Transplantation / Q000379:methods*; D008991:Monitoring, Physiologic; D010215:Papio; D013552:Swine; D013686:Telemetry; D014183:Transplantation, Heterologous / Q000379:methods*; D016042:Transplantation, Heterotopic / Q000379:methods*