The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses.
There are differences between human individuals and between mouse strains in levels of mu opiate receptor (muOR) expression, responses to painful stimuli, and responses to opiate drugs. One of the best candidates for contributing to these differences is variation at the muOR gene locus. Support for this idea comes from analyses of the human and murine muOR genes. Assessments of individual differences in human muOR expression add further support. Studies with mice, including knockout-transgenic, quantitative trait locus, and strain-comparison studies, also strongly support the possibility that muOR gene alleles would be strong candidates for contributing to individual differences in human nociception and opiate drug responses. This paper reviews current analyses of the murine and human muOR genes, their important variants, and correlations between these variants and opiate influences on pain.
Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. guhl@irp.nida.nih.gov
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D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009294:Narcotics / Q000494:pharmacology; D010146:Pain / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D017450:Receptors, Opioid, mu / Q000235:genetics*
D009294:Narcotics; D017450:Receptors, Opioid, mu