Synaptic vesicle docking and fusion.
Neurotransmitter secretion shares many features with constitutive membrane trafficking. In both cases, vesicles are targeted to a specific acceptor membrane and fuse via a series of protein-protein interactions. Recent work has added to the list of protein complexes involved and is beginning to define the order in which they act. The rapid fusion, precise regulation and plasticity characteristic of synaptic exocytosis probably results from the addition of specialized regulators.
Department of Pharmacology, D-431 Health Sciences Building, Box 357280, University of Washington, Seattle, Washington 98195-7280, USA. bajjalie@u.washington.edu
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D000818:Animals; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000737:chemistry / Q000502:physiology*