[Effect of naftidrofuryl (praxilene) on optic nerve head blood flow in the patient with glaucoma].
OBJECTIVE
To evaluate the effects of an S2 specific antiserotonine agent (Naftidrofuryl) on the optic nerve head blood flow in glaucomatous patient.


METHODS
11 glaucomatous subjects were enrolled in the study. After administration of 200 mg naftidrofuryl twice daily for 7 days: values of optic nerve head blood flow (Fonh), velocity and volume were recorded in the temporal rim and cup of the optic nerve head. Blood flow measurements were performed by laser doppler flow-metry at day 0 and day 7 before and one and two hours after drug administration.


RESULTS
Our study showed a significant improvement of perfusion pressure (p = 0.02) at day 7 and an increase of mean ophthalmique artery pressure (p = 0.03).


CONCLUSIONS
Our preliminary results on a small number of patients and a short follow-up indicate that the use of naftidrofuryl may enhance optic nerve head blood flow in glaucomatous patients. Further studies may confirm these results.
Hôpital Ophtalmique Jules Gonin, Lausanne.
F
F
Achache
P
P
Titzé
A
A
Movaffaghy
A
A
Mermoud
D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000008:administration & dosage* / Q000009:adverse effects; D009898:Optic Disk / Q000098:blood supply*; D012702:Serotonin Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D012702:Serotonin Antagonists; D014665:Vasodilator Agents; D009257:Nafronyl
Effet du Naftidrofuryl (Praxilène) sur le flux sanguin de la tête du nerf optique du patient glaucomateux.