Induction of endogenous coenzyme Q biosynthesis by administration of peroxisomal inducers.
A large number of chemical compounds have been identified which cause peroxisomal proliferation and induce a number of enzymes, mainly those participating in lipid metabolism. Administration of these drugs/chemicals to rats increased coenzyme Q levels in the blood and most of the organs. Levels were raised in all cellular membranes of such organs. The extent of induction of this lipid was 8-fold in young animals but decreased during aging and was absent at 1.5 year of age. One of the regulating factors of the mevalonate pathway is farnesol, which is produced by dephosphorylation of farnesyl-PP and eliminated by phosphorylation including two kinases. Future research will involve a search for modified intermediary metabolites, which increase coenzyme Q synthesis and thereby efficiently elevate the level of this lipid in conditions of deficiency.
Department of Biochemistry, University of Stockholm, Sweden.
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M
Turunen
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Sindelar
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G
Dallner
D000375:Aging; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002994:Clofibrate / Q000494:pharmacology; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004051:Diethylhexyl Phthalate / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009928:Organ Specificity; D015388:Organelles / Q000187:drug effects / Q000378:metabolism*; D020025:Peroxisome Proliferators / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014451:Ubiquinone / Q000096:biosynthesis* / Q000097:blood
D020025:Peroxisome Proliferators; D014451:Ubiquinone; D003687:Dehydroepiandrosterone; D004051:Diethylhexyl Phthalate; D002994:Clofibrate; D001241:Aspirin