Serum markers of treatment success in leprosy.
Intercellular adhesion molecule-1 (ICAM-1) and E-selectin and other variables were evaluated as possible markers of the success of multidrug therapy (MDT) in leprosy. Multibacillary (MB, N = 45) and paucibacillary (PB, N = 29) leprosy patients were examined during MDT, which typically lasted 12 months for MB and 6 months for PB patients. Serum values for total protein, albumin, immunoglobulin gamma (IgG), ICAM-1, and E-selectin (selectin) were recorded, as were lesion type, number, and distribution. Response at the end of therapy was assessed as good, fair, or poor. The bacterial index (BI) of lesions was measured at the beginning and end of therapy. The earlier reported findings of this investigation are herein re-examined.


RESULTS
age and lowered serum albumin correlated with the poorer condition of the patients, as did elevated selectin. Albumin was inversely correlated with the BI (p = 0.008) in MB patients, and IgG was positively correlated (p = 0.009). ICAM and E-selectin alone were not useful markers of individual patient condition. A regression combining serum albumin under 41 g/l, age and E-selectin was able to identify 85% of the patients in poorer condition.


CONCLUSIONS
serum albumin was a useful nonspecific marker of both patient condition and infection. Age is an important negative factor in patient response. Albumin and IgG correlate with the BI and with each other (p = 0.011) in MB patients, but not in PB patients.
MacLean
S
S
Department of Neurology, University Hospital, Gottingen, Germany.
Stietenroth
K
K
Prange
H
H
Pai
V V
VV
Ganapati
R
R
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002648:Child; D002991:Clofazimine / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007917:Leprostatic Agents / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000187:drug effects; D012293:Rifampin / Q000627:therapeutic use; D012709:Serum Albumin / Q000032:analysis*; D016896:Treatment Outcome
D015415:Biomarkers; D019040:E-Selectin; D007074:Immunoglobulin G; D007917:Leprostatic Agents; D012709:Serum Albumin; D018799:Intercellular Adhesion Molecule-1; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin