Phlebosclerosis of the colon with positive anti-centromere antibody.
A 56-year-old woman with symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enema study. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. No cell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CREST syndrome were observed. We therefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CREST syndrome.
Department of Internal Medicine, Sumitomo Hospital, Osaka.
T
T
Kitamura
M
M
Kubo
T
T
Nakanishi
H
H
Fushimi
K
K
Yoshikawa
N
N
Taenaka
T
T
Furukawa
T
T
Tsujimura
M
M
Kameyama
D001323:Autoantibodies / Q000032:analysis*; D017675:CREST Syndrome / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D002503:Centromere / Q000276:immunology*; D003106:Colon / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008642:Mesenteric Veins / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D011859:Radiography; D012598:Sclerosis; D014652:Vascular Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies