Lymphatic absorption of phytosterol oxides in rats.
Two of the main classes of oxyphytosterols (7-keto and epoxides) were synthesized from sitosterol and campesterol and given to mesenteric duct-cannulated adult male rats. Lymph was collected during 24 h and was analyzed for oxysterols. The results showed that the lymphatic recovery of the phytosterol oxides was low: 4.7% of the given dose for epoxy derivatives and 1.5% for 7-keto compounds. The campesterol oxides presented a better absorption than the sitosterol oxides. During the process of absorption, the epoxyphytostanols were also partly transformed in campestanetriol and stigmastanetriol.
Grandgirard
A
A
Unité de Nutrition Lipidique, INRA, Dijon, France. grandgirard@dijon.inra.fr
Sergiel
J P
JP
Nour
M
M
Demaison-Meloche
J
J
Giniès
C
C
D000818:Animals; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D010840:Phytosterols / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D010840:Phytosterols