Intracranial EEG with very low frequency activity fails to demonstrate an advantage over conventional recordings.
OBJECTIVE
Conventional scalp and intracranial EEG is recorded within a limited band of frequencies (0.3-70 Hz) based on the premise that clinically relevant cerebral activity occurs within this frequency range. Ikeda et al. recently demonstrated focal very low frequency activity (VLFA), <0.3 Hz, at seizure onset for both intra- and extracranial recordings. The purpose of this investigation was prospectively to study VLFA during seizures in intracranial recordings to determine whether activity in this frequency range provides useful information regarding localization of seizure onset and spread.


METHODS
Patients undergoing intracranial electrode implantation were studied by using a high-pass filter of 0.01 Hz. The timing, location, and pattern of seizure onset were first determined by using a digital high-pass filter of 0.3 Hz (conventional seizure onset). Seizures were then reviewed without digital filters and the presence of VLFA recorded, along with its timing and location.


RESULTS
Forty-seven seizures were recorded in four patients. VLFA was not observed in 29 seizures and, in one other case, VLFA occurred simultaneous with movement. Of seizures with VLFA (n = 17), the timing and location of VLFA were not consistent with those of conventional seizure onset or propagation.


CONCLUSIONS
Our study failed to demonstrate any clinical advantage of intracranial telemetry recordings with a high-pass filter of 0.01 Hz over conventional recordings with regard to determining the timing and location of seizure onset and propagation.
Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.
D W
DW
Gross
J
J
Gotman
L F
LF
Quesney
F
F
Dubeau
A
A
Olivier
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods / Q000706:statistics & numerical data*; D004594:Electrophysiology; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000503:physiopathology; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011446:Prospective Studies