[Investigation of the physico-chemical properties of deramciclane (EGIS-3886), a new anxiolytic compound. Ionization and lipophilicity].
Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS-3886), a novel anxiolytic compound being under clinical trial were investigated. The aqueous pKa value and the octanol/water partition coefficient (logP) have been determined using validated analytical approaches. The favourable pharmacokinetic properties of deramciclane are interpreted on the bases of its ionization capability and extreme high lipophilicity.
Takácsné Novák
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Semmelweis Orvostudományi Egyetem Gyógyszerészi Kémiai Intézet, Budapest.
D014151:Anti-Anxiety Agents / Q000737:chemistry*; D001892:Camphanes / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility; D012997:Solvents
D014151:Anti-Anxiety Agents; D001892:Camphanes; D012997:Solvents; C060555:deramciclane
A deramciklán (EGIS-3886), egy új anxiolitikum fizikai-kémiai tulajdonságainak vizsgálata. Ionizáció és lipofilitás.