[A case of gastric carcinoma treated effectively with 5'-DFUR].
A 79-year-old male was admitted to our hospital for further examination on gastric carcinoma (1' type) in the cardia. The histology of biopsied tissue was moderately differentiated adenocarcinoma (tub2). The patient refused a gastrectomy and received three cycles of local injection therapy with OK-432 + Beriplast into the tumor. However, the tumor showed no decrease in size. Considering the quality of life, the patient was given out patient treatment with 5'-DFUR (Furtulon, 800 mg/day). Three months later, the patient showed a partial response (PR) on the basis of gastric X-ray and endoscopic findings. No adverse reactions to the drug were seen. The patient has been receiving the same drug since then, and has continued to show PR for 15 months. Biopsied tissues were checked immunohistochemically for expression of thymidine phosphorylase (TdRPase), and changes in tissue TdRPase level were examined by ELISA. The TdRPase level decreased with shrinking of the tumor. These results suggest that the shrinking of tumor following 5'-DFUR therapy is closely related to TdRPase.
Gotoh
M
M
Division of Internal Medicine, Hokusetsu General Hospital.
Takiuchi
H
H
Hirata
I
I
Iyama
M
M
Inoue
R
R
Itabashi
T
T
Egashira
Y
Y
Inoue
T
T
Kurisu
Y
Y
Tanaka
M
M
Shimamoto
C
C
Katsu
K
K
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D000284:Administration, Oral; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002299:Cardia; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D013939:Thymidine Phosphorylase / Q000378:metabolism
D000970:Antineoplastic Agents; D005467:Floxuridine; D013939:Thymidine Phosphorylase; C025034:doxifluridine