Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature.
OBJECTIVE
To report 4 cases of hybrid carcinoma and to review the literature on these rare neoplasms of the salivary gland.


METHODS
Hematoxylin-eosin-stained, formalin-fixed, paraffin-embedded tissue sections from 3 parotid tumors and 1 palate tumor were examined.


RESULTS
The cases were classified as adenoid cystic and mucoepidermoid carcinoma, adenoid cystic and epithelial-myoepithelial carcinoma, epithelial-myoepithelial and salivary duct carcinoma, and adenoid cystic and salivary duct carcinoma. All patients were men, 28 to 71 years old; 3 patients presented with parotid mass, and 1 patient presented with palatal mass. One patient presented with facial nerve paralysis and pain. The soft palatal tumor was a slowly growing mass with maxillary sinus involvement at the time of the diagnosis. All patients were treated with surgery and radiotherapy.


CONCLUSIONS
Correct identification of 2 or more neoplastic entities will help assess the aggressiveness and metastatic potential of the tumor and influence the clinical course and treatment.
Department of Pathology, University of Texas Medical School, Houston 77030, USA.
C M
CM
Croitoru
P A
PA
Suarez
M A
MA
Luna
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology*; D010159:Palate; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed