[Effect of green vegetable on digestive tract absorption of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in rats].
The effect green vegetable on fecal excretion of polychlorinated dibenzo-p-dioxin (PCDD) congeners and polychlorinated dibenzofuran (PCDF) congeners was examined in male rats. The rats were administered 10% vegetable diets or a basal diet containing 0.2 ml of the causal rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for five days. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Komatsuna, Mitsuba, Spinach and Perilla were 7.6-11.6 and 6.5-9.4 times higher, respectively, than that in the group fed with a basal diet. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Kale, Chinese chive, Shungiku, Chingentsuai, Green lettus and Sweet pepper were 3.3-4.8 and 4.3-4.5 times higher, respectively, than that in the basal group. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Chinese cabbage, Broccoli, Onion, Welsh onion, Cabbage and Celery were 1.6-3.0 and 1.2-1.3 times higher, respectively, than that in the basal group. A correlation between Chllophyll consumption and fecal excretion of PCDD and PCDF congeners was highly significant (p < 0.01). Next, we investigated the fecal excretion of PCDD and PCDF congeners from day 8 to day 35 in rats administered with 0.5 ml of the rice oil. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with Perilla, Kale and Spinach were 3.1-4.9 and 3.0-3.6 times higner, respectively, than that in the basal group. The presents results suggest that the green vegetables might be useful in treatment of humans exposed to PCDD and PCDF congeners.
Fukuoka Institute of Health and Environmental Sciences, Japan.
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Morita
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Matsueda
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Iida
D000818:Animals; D001572:Benzofurans / Q000032:analysis / Q000493:pharmacokinetics*; D002734:Chlorophyll; D004032:Diet; D004043:Dietary Fiber; D005243:Feces / Q000737:chemistry; D005506:Food Contamination; D007408:Intestinal Absorption; D008297:Male; D012275:Oryza; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D011108:Polymers / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012989:Soil Pollutants / Q000032:analysis / Q000493:pharmacokinetics*; D014675:Vegetables
D001572:Benzofurans; D004043:Dietary Fiber; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; D012989:Soil Pollutants; C016068:polychlorodibenzofuran; D002734:Chlorophyll