Association of angiotensin-converting enzyme gene polymorphism and renal pathology in Japanese children with IgA nephropathy.
Polymorphism of the gene that codes for angiotensin I-converting enzyme (ACE) is associated with increased severity of immunoglobulin A (IgA) nephropathy in adult patients. We evaluated the relationship between the polymorphism of ACE genotypes and the pathological and clinical findings in Japanese children with IgA nephropathy. Patients with moderate/diffuse mesangial proliferation, glomerular sclerosis and tubulointerstitial damage showed a significant increase of the D/D type compared to those who had mild/focal mesangial proliferation, without glomerular sclerosis or tubulointerstitial damage (p < 0.05). Proteinuria at the first renal biopsy was significantly higher in the former group compared with the latter group except glomerular sclerosis (p < 0.01). IgA nephropathy patients with tubulointerstitial damage also showed an increased serum creatinine level compared to patients without the damage (p < 0.03). We conclude that ACE gene polymorphism may be correlated with the prognosis of IgA nephropathy in Japanese children.
Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
T
T
Asano
N
N
Tatsuma
J
J
Yoshida
R
R
Ohashi
K
K
Ambo
M
M
Tsuchiya
M
M
Murakami
N
N
Yamanaka
M
M
Honda
M
M
Yamamoto
D001706:Biopsy; D002648:Child; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012598:Sclerosis
D007703:Peptidyl-Dipeptidase A