The effect of growth hormone treatment on stature in Aarskog syndrome.
We describe 19 males with Aarskog syndrome who were treated with growth hormone (GH) and enrolled in the National Cooperative Growth Study (NCGS). There was a significant increase in both growth rate (3.9 +/- 1.9 cm/yr vs 8.9 +/- 1.7 cm/yr, p < 0.001) and height SD score (change in HtSDS = 1.0 +/- 0.8). The increase in HtSDS was dependent on treatment duration, frequency of injections, weight-for-height SDS, and HtSDS at enrollment. The results of our study suggest a positive effect of GH treatment on growth and adult height in Aarskog syndrome patients.
Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
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Blethen
D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects*; D002648:Child; D019465:Craniofacial Abnormalities / Q000175:diagnosis; D004305:Dose-Response Relationship, Drug; D004392:Dwarfism / Q000175:diagnosis / Q000628:therapy*; D005837:Genitalia, Male / Q000002:abnormalities; D006128:Growth / Q000187:drug effects; D013006:Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013577:Syndrome; D013995:Time
D013006:Growth Hormone