Angiocentric lymphoma involving the temporal bone in a child.
Involvement of the temporal bone in patients with malignant lymphomas is very rare. Most of the reported cases have been clinically asymptomatic and were diagnosed only by post-mortem examinations. We present a nasal, paranasal, nasopharyngeal lymphoma that occurred in a 12-year-old child and also involved the temporal bone. Clinical presentation began with bilateral chronic otitis media. Histopathologically, tumor was found to be an angiocentric lymphoma of B-cell origin. Association with Epstein-Barr virus could not be demonstrated. Despite combination chemotherapy (with cyclophosphamide, vincristine, doksorubicine, prednisolone, L-asparaginase, cytosine arabinoside, metotraxate) and radiotherapy (to 40 Gy), disease progressed locally as well as to cervical lymph nodes and the lungs.
Department of Otorhinolaryngology, Hacettepe University School of Medicine, Ankara, Turkey.
O
O
Cakmak
T
T
Kutluk
M U
MU
Akyol
S
S
Ruacan
D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009383:Neoplasms, Vascular Tissue / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D010033:Otitis Media / Q000175:diagnosis; D011859:Radiography; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D013701:Temporal Bone / Q000098:blood supply*