Dietary fat and carcinogenesis.
Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important. At present, the mechanism by which dietary fat modulates carcinogenesis has not been elucidated. The effects of dietary fat on the development of tumours have been summarized in the present review with emphasis on colorectal, pancreas, breast and prostate cancer. It is concluded that influence on synthesis of prostaglandins and leukotrienes may be the universal mechanism by which dietary fats modulate carcinogenesis.
Department of General Toxicology, TNO Nutrition and Food Research Institute, PO Box 360, Zeist 3700 AJ, Netherlands. woutersen@voeding.tno.nl
R A
RA
Woutersen
M J
MJ
Appel
A
A
van Garderen-Hoetmer
M V
MV
Wijnands
D000818:Animals; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000209:etiology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D011453:Prostaglandins / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar
D004041:Dietary Fats; D015289:Leukotrienes; D011453:Prostaglandins