Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells.
ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negatively regulate the activation of cells when co-crosslinked with ITAM containing receptors, illustrates the inhibitory processes by the negative regulation of B-, NK-, T-cells and mast cells and summarizes current views on the mechanism of ITIM-mediated inhibition.
Research Group of the Hungarian Academy of Science at the Department of Immunology, Eötvös Loránd University, Göd.
J
J
Gergely
I
I
Pecht
G
G
Sármay
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000502:physiology*; D014443:Tyrosine / Q000502:physiology*
D011971:Receptors, Immunologic; D014443:Tyrosine