HLA antigens in Iranian patients with B-cell chronic lymphocytic leukemia.
The frequency of HLA class-I and class-II antigens was investigated in 32 Iranian patients with B-cell chronic lymphocytic leukemia (B-CLL), using the microlymphocytotoxicity method. A significant increase in the HLA-B13 (P<0.01) and DR53 (P < 0.05) and a significant negative association with the A11 (P < 0.05), B35 (P < 0. 05), Cw3 (P < 0.05), and DR1 (P < 0.02) antigens were observed in these patients, compared to the control normal population. These results suggest involvement of some HLA antigens in the multifactorial process of predisposition to B-CLL.
School of Medical Sciences, Tarbiat Modarres University, Department of Immunology, Tehran, Iran.
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Moazzeni
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Amirzargar
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Shokri
D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007492:Iran; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II