Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus.
The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.
Department of Pharmacognosy, National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
X
X
Shen
S B
SB
Krasnoff
S W
SW
Lu
C D
CD
Dunbar
J
J
O'Neal
B G
BG
Turgeon
O C
OC
Yoder
D M
DM
Gibson
M T
MT
Hamann
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
C120732:3-anhydroophiobolin B; D000903:Antibiotics, Antineoplastic; D000962:Antimalarials; D001643:Bridged Bicyclo Compounds