Gene rearrangements in T-cell lymphoblastic lymphoma.
This study presents an examination of the Ig heavy chain (IgH) and T-cell receptor gamma (TCRgamma) genes in a series of 39 CD3-positive T-cell acute lymphoblastic leukaemia (ALL) cases with and without co-expression of CD79a; 30/39 cases had a rearrangement of the TCRgamma genes and two of these 30 cases also demonstrated an IgH rearrangement. No cases had solely an IgH rearrangement. The conclusion of the study is that lymphoblastic lymphoma cases that are positive for CD3 are of T-cell lineage, regardless of CD79a expression.
Department of Cellular Science, John Radcliffe Hospital, University of Oxford, U.K.
E
E
Pilozzi
H K
HK
Müller-Hermelink
B
B
Falini
C
C
de Wolf-Peeters
C
C
Fidler
K
K
Gatter
J
J
Wainscoat
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D051925:CD79 Antigens; D002648:Child; D002675:Child, Preschool; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D007223:Infant; D007231:Infant, Newborn; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000145:classification / Q000235:genetics* / Q000276:immunology; D008297:Male; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics* / Q000276:immunology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D051925:CD79 Antigens; C497881:CD79A protein, human; D007143:Immunoglobulin Heavy Chains; D011947:Receptors, Antigen, B-Cell