Clinical implications of the correlation between coenzyme Q10 and vitamin B6 status.
The endogenous biosynthesis of the quinone nucleus of coenzyme Q10 (CoQ10) from tyrosine is dependent on adequate vitamin B6 nutriture. Lowered blood and tissue levels of CoQ10 have been observed in a number of clinical conditions. Many of these clinical conditions are most prevalent among the elderly. Kalen et al. have shown that blood levels of CoQ10 decline with age. Similarly, Kant et al. have shown that indicators of vitamin B6 status also decline with age. Blood samples were collected from 29 patients who were not currently being supplemented with either CoQ10 or vitamin B6. Mean CoQ10 concentrations was 1.1 +/- 0.3 micrograms/ml of blood. Mean specific activities of EGOT was 0.30 +/- 0.13 mumol pyruvate/hr/10(8) erythrocytes and the mean percent saturation of EGOT with PLP was 78.2 +/- 13.9%. Means for all parameters were within normal ranges. Strong positive correlation was found between CoQ10 and the specific activity of EGOT (r = 0.5787, p < 0.001) and between CoQ10 and the percent saturation of EGOT with PLP (r = 0.4174, p < 0.024). Studies are currently in progress to determine the effect of supplementation with vitamin B6 of blood CoQ10 levels. It appears prudent to recommend that patients receiving supplemental CoQ10 be concurrently supplemented with vitamin B6 to provide for better endogenous synthesis of CoQ10 along with the exogenous CoQ10.
Willis
R
R
Institute for Biomedical Research, University of Texas at Austin 78712, USA.
Anthony
M
M
Sun
L
L
Honse
Y
Y
Qiao
G
G
D000375:Aging / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood*; D003067:Coenzymes; D006321:Heart / Q000254:growth & development; D006801:Humans; D007668:Kidney / Q000254:growth & development / Q000378:metabolism; D008099:Liver / Q000254:growth & development / Q000378:metabolism; D008168:Lung / Q000254:growth & development / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011736:Pyridoxine / Q000097:blood*; D051381:Rats; D013154:Spleen / Q000254:growth & development / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism
D015415:Biomarkers; D003067:Coenzymes; D014451:Ubiquinone; D014443:Tyrosine; C024989:coenzyme Q10; D011736:Pyridoxine