Histopathological findings in proliferative membrane from a patient with sarcoid uveitis.
BACKGROUND
Sarcoid uveitis is occasionally accompanied by proliferative changes, such as retinal neovascularization and vitreous hemorrhage. Steroid administration, retinal photocoagulation, and vitrectomy may be indicated in such proliferative cases.


METHODS
A 19-year-old woman presented with proliferative sarcoid uveitis accompanied by recurrent vitreous hemorrhage.


METHODS
At the initial examination, bilateral vitreous opacity, retinal exudates, mild vitreous hemorrhage, retinal vasculitis, and neovascularization of the retina and optic disc were observed. Although prednisolone was administered and panretinal photocoagulation was performed several times, recurrent vitreous hemorrhage continued. Since the vitreous hemorrhage was not absorbed, pars plana vitrectomy and lensectomy were performed. After surgery, neovascularization and intraocular inflammation decreased, and the corrected visual acuity in the right eye improved to 20/50. Histopathologic analysis of the proliferative membrane removed during surgery revealed substantial neovascularization and numerous neutrophils in the vessels.


CONCLUSIONS
Based on these findings, an inflammatory reaction as well as retinal ischemia were thought to be involved in the proliferative changes in this patient.
Miyao
A
A
Department of Ophthalmology, Nishijin Hospital, Kyoto, Japan.
Ikeda
T
T
Matsumoto
Y
Y
Uchida
K
K
Machida
T
T
Hongo
M
M
Kinoshita
S
S
D000328:Adult; D002455:Cell Division; D019773:Epiretinal Membrane / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017075:Laser Coagulation; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012008:Recurrence; D015861:Retinal Neovascularization / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D012507:Sarcoidosis / Q000150:complications*; D014606:Uveitis, Anterior / Q000150:complications*; D014792:Visual Acuity; D014823:Vitreous Hemorrhage / Q000209:etiology / Q000473:pathology* / Q000628:therapy
D005938:Glucocorticoids; D011239:Prednisolone