Age-related changes in number of phosphorylated tau-immunopositive particles in neurons of facial and lateral cerebellar nuclei of normal and groggy mutant rats.
The numbers of cytoplasmic particles immunopositive to an anti-phosphorylated tau antibody (AT8) were counted in the neurons of facial and lateral cerebellar nuclei of Slc:Wistar and groggy mutant rats aged from 20 to 360 days. These particles greatly increased in number from 20 to 30 days of age in the Slc:Wistar rats, whereas in the groggy rats, they increased at such a slower rate than in the Slc:Wistar rats as to reach the peak at 60 days of age. The particles decreased to lower levels at 120 days of age in both rat strains, and increased again from 180 days of age. The results indicate that the numbers of AT8-immunopositive particles in neuronal cytoplasm change dynamically according to the physiological state associated with the growing and aging processes.
Department of Embryology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan. ikuo@inst-hsc.pref.aichi.jp
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D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002529:Cerebellar Nuclei / Q000378:metabolism* / Q000473:pathology; D005154:Facial Nerve / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009474:Neurons / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D016875:tau Proteins / Q000032:analysis*
D016875:tau Proteins