Lethal capillary leak syndrome after a single administration of interferon beta-1b.
Interferon beta-1b (IFNbeta-1b) is a potent immunomodulatory drug in the treatment of MS. We report a lethal capillary leak syndrome after the administration of IFNbeta-1b in a patient with disseminated white matter disease, monoclonal gammopathy, and acquired C1 inhibitor (C1-INH) deficiency. IFNbeta-1b may cause a transient release of proinflammatory cytokines finally resulting in an uninhibited activation of the complement cascade in patients with C1-INH deficiency.
Schmidt
S
S
Department of Neurology, University of Bonn, Germany.
Hertfelder
H J
HJ
von Spiegel
T
T
Hering
R
R
Harzheim
M
M
Lassmann
H
H
Deckert-Schlüter
M
M
Schlegel
U
U
D000328:Adult; D001344:Autopsy; D001921:Brain / Q000473:pathology; D019559:Capillary Leak Syndrome / Q000139:chemically induced* / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007238:Infarction / Q000473:pathology; D000068556:Interferon beta-1a; D000068576:Interferon beta-1b; D016899:Interferon-beta / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000628:therapy*; D011994:Recombinant Proteins / Q000009:adverse effects; D013116:Spinal Cord / Q000473:pathology
D003174:Complement C1 Inactivator Proteins; D011994:Recombinant Proteins; D000068576:Interferon beta-1b; D016899:Interferon-beta; D000068556:Interferon beta-1a