Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide.
N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), in preventing S. mansoni infections in mice. Both AI3-37220 and DEET conferred 100% protection against S. mansoni infection via percutaneous exposure to cercariae.
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA.
W E
WE
Secor
G L
GL
Freeman
R A
RA
Wirtz
D000818:Animals; D003671:DEET / Q000494:pharmacology / Q000627:therapeutic use*; D007302:Insect Repellents / Q000494:pharmacology / Q000627:therapeutic use*; D007422:Intestines / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000517:prevention & control*; D012867:Skin / Q000187:drug effects
D007302:Insect Repellents; D010880:Piperidines; D003671:DEET; C075892:1-(3-cyclohexen-1-ylcarbonyl)-2-methylpiperidine