Ultrastructural alterations in glomerulopathy associated with hydatidosis in sheep.
In the present study we investigated the ultrastructural alterations occurring in the renal glomeruli of sheep with hydatidosis. Renal samples from 39 sheep, 34 with hydatidosis and 5 without parasitosis, were examined by transmission electron microscopy. Additionally, biochemical analysis was performed by determining serum concentrations of creatinine, urea, total protein and albumin. The ultrastructural alterations identified were the presence of dense mesangial, subendothelial and intra-membranous deposits, mesangial cell proliferation with areas showing segmental sclerosis and interposition of mesangial cells with the formation of a neomembrane. Biochemical analysis revealed a significant increase in total serum protein in the experimental group compared with the control. Our results demonstrated that glomerulonephritis associated with hydatidosis in sheep can be classified into four categories: minimal lesions, mesangial glomerulonephritis, segmental and focal glomerulonephritis and membranoproliferative glomerulonephritis, being membranoproliferative and mesangial glomerulonephritis the most predominant categories.
Center for Health Sciences, UNISNOS, Sao Leopoldo, RS, Brasil. hdaudtbios.unisinos.tche.br
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Lizardo-Daudt
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Albano Edelweiss
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D003404:Creatinine / Q000097:blood; D004443:Echinococcosis / Q000097:blood / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D005921:Glomerulonephritis / Q000150:complications / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008854:Microscopy, Electron; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*; D014508:Urea / Q000097:blood
D001798:Blood Proteins; D012709:Serum Albumin; D014508:Urea; D003404:Creatinine