Genetic aberrations in oligodendroglial tumours: an analysis using comparative genomic hybridization (CGH).
Four low-grade oligodendrogliomas, nine anaplastic oligodendrogliomas and two mixed oligoastrocytomas were investigated for chromosomal aberrations by comparative genomic hybridization on formalin-fixed, paraffin-embedded tissue samples. The most frequent losses observed involved 1p, 9p, 10pq, 14q, 16p, 19q, while the most frequent gains were seen on 7pq, 11pq, 17p, 19pq, and Xp. In one oligodendroglioma, a highly specific amplification of 1q32.1 was seen. The frequent losses of 14q have not been reported previously. In the two cases of mixed oligoastrocytomas multiple gains and losses were found that did not show a clear overlap with the alterations found in the pure oligodendrogliomas.
Department of Pathology, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. kros@path.fgg.eur.nl
J M
JM
Kros
P R
PR
van Run
J C
JC
Alers
H B
HB
Beverloo
M J
MJ
van den Bent
C J
CJ
Avezaat
H
H
van Dekken
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D005910:Glioma / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology; D016612:Paraffin Embedding