Ticlopidine-induced prolonged cholestasis: a case report.
We report a case of ticlopidine-induced prolonged cholestasis in a 60-year-old man with no previous hepatobiliary disease who presented with sudden right upper abdominal pain, jaundice and pruritus three months after starting ticlopidine therapy. Other drugs taken by the patient were not considered probable causes. The diagnostic evaluation showed no biliary obstruction and other possible causes of intra-hepatic cholestasis were excluded. The liver biopsy showed a cholestatic hepatitis with bile duct damage. The disease ran a severe and protracted course, but symptoms and jaundice eventually subsided five months after drug withdrawal. More than a year later, relevant abnormalities of liver function tests consistent with anicteric cholestasis still persist, fulfilling criteria for a minor form of drug-induced prolonged cholestasis. This syndrome has been reported infrequently in relation to several drugs, mainly chlorpromazine, and only once with ticlopidine.
Department of Gastroenterology, Coimbra University Hospital, Portugal.
P
P
Amaro
A
A
Nunes
F
F
Maçôas
P
P
Ministro
J
J
Baranda
A
A
Cipriano
I
I
Martins
A
A
Rosa
I
I
Pimenta
A
A
Donato
D
D
Freitas
D002779:Cholestasis / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*; D013997:Time Factors
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine