[Paraneoplastic Cushing's syndrome and small cell bronchial carcinoma].
Approximately 30% of small-cell bronchogenic cancers are associated with hypersecretion of ACTH. However, in most cases, there is no clinical expression. When a paraneoplastic Cushing syndrome occurs, it is an independent factor of poor prognosis. Management is extremely complex. Treatment must be based on high dose inhibitors prior to chemotherapy. Opportunistic infections, often fungal infections, are the main complications, even outside periods of aplasia, and cause significantly earlier mortality.
Pavillon Laënnec, Hôpital Civil, Strasbourg.
B
B
Mennecier
L
L
Moreau
B
B
Goichot
G
G
Pauli
E
E
Quoix
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D002283:Carcinoma, Bronchogenic / Q000150:complications* / Q000401:mortality; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000401:mortality; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors
D000324:Adrenocorticotropic Hormone
Syndrome de Cushing paranéoplasique et carcinome bronchique à petites cellules.