Rothmund-Thomson syndrome with herpes encephalitis.
A 4-year-old Japanese boy with Rothmund-Thomson syndrome suffered from severe herpes encephalitis at 5 months of age. The serum level of immunoglobulin G was low and the responsiveness of peripheral blood mononuclear cells to bacterial superantigens was poor. It was suggested that these immunological abnormalities, possibly associated with Rothmund-Thomson syndrome, led to severe infection with herpes simplex virus in our patient.
Department of Dermatology, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan. itoutai@hama-med.ac.jp
T
T
Ito
Y
Y
Tokura
S
S
Moriwaki
K
K
Yasuda
A
A
Ohnishi
F
F
Furukawa
K
K
Yamaizumi
M
M
Takigawa
D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000150:complications*; D006561:Herpes Simplex / Q000150:complications*; D006801:Humans; D017099:IgG Deficiency / Q000150:complications; D007111:Immunity, Cellular; D007223:Infant; D008297:Male; D011038:Rothmund-Thomson Syndrome / Q000150:complications* / Q000276:immunology