Characterization of a novel HLA-Cw*04 variant in a Laotian family: HLA-Cw*0406.
The sequence of a new HLA-Cw*04 allele has been identified in a Laotian family. This allele, designated Cw*0406, differs from Cw*0403 by a single nucleotide substitution at codon 156 (CGG-->CTG) in the alpha2 domain, leading to an amino acid change from Arginine to Leucine. Further screening by specific amplification of two ethnically different populations, i.e. French (n=150) and Lebanese (n=100), provided no case of Cw*406, suggesting that the distribution of this allele may be restricted.
Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital Saint Louis, and INSERM U396, Paris, France.
E
E
Carbonnelle
J C
JC
Poirier
C
C
Fortier
F
F
Marzais
C J
CJ
Visser
C
C
Borie
A
A
Toubert
C
C
Raffoux
D
D
Charron
R
R
Tamouza
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics / Q000276:immunology; D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics; D003062:Codon / Q000235:genetics; D005091:Exons / Q000276:immunology; D005260:Female; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007812:Laos; D007930:Leucine / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D010375:Pedigree
D003062:Codon; D015236:HLA-C Antigens; C119147:HLA-C*04:06 antigen; D001120:Arginine; D007930:Leucine