Corneal wound healing after superficial foreign body injury: vitamin A and dexpanthenol versus a calf blood extract. A randomized double-blind study.
A prospective randomized double-blind clinical study was performed to investigate corneal wound healing after treatment either with an eye gel containing calf blood extract or an eye ointment containing vitamin A and dexpanthenol. A total of 54 outpatients were included in this study, all treated for corneal foreign body injury. The size of the corneal lesions was measured by planimetry on days 0, 1, and on the following days until complete epithelial healing occurred. Results showed the calf blood extract eye gel to be statistically more effective in promoting corneal wound healing, especially in patients with wound areas larger than 6 mm(2).
County Hospital of Salzburg, Austria.
S F
SF
Egger
V
V
Huber-Spitzy
E
E
Alzner
C
C
Scholda
V P
VP
Vecsei
D000183:Actihaemyl / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003315:Cornea / Q000187:drug effects*; D065306:Corneal Injuries; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005129:Eye Foreign Bodies / Q000188:drug therapy* / Q000601:surgery; D015807:Eye Injuries, Penetrating / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D005782:Gels; D009883:Ophthalmic Solutions; D014801:Vitamin A; D010205:Pantothenic Acid; C007288:dexpanthenol; D000183:Actihaemyl