Cellular neurothekeoma with possible neuroendocrine differentiation.
We report a case of cellular neurothekeoma showing unusual immunohistochemical findings and occurring on the left upper arm of a healthy 48-year-old woman. She presented with a 1 cm, red, asymptomatic, dermal nodule of 1 year duration. A biopsy showed dermal proliferation of plexiform fascicles of spindle-shaped or polygonal cells with plentiful eosinophilic cytoplasms. The immunohistochemical profile included negative stains for S-100, CD34, factor XIIIa, CD68, HMB45, cytokeratins, and EMA, strongly positive stains for neuron specific enolase (NSE), synaptophysin, and chromogranin A, and focally positive ones for NKI/C3 and alpha-smooth muscle actin. Ultrastructural analysis showed undifferentiated mesenchymal cells with cytoplasmic projections and abundant RER. Although we couldn't find any confirmative cell type in this cellular tumor, we believe that cellular neurothekeoma is predominantly composed of undifferentiated cells that can exhibit features of neuroendocrine cells in addition to fibroblastic or myofibroblastic ones, suggesting a divergent cell origin.
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
S E
SE
Chang
T J
TJ
Lee
J Y
JY
Ro
J H
JH
Choi
K J
KJ
Sung
K C
KC
Moon
J K
JK
Koh
D001707:Biopsy, Needle; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008648:Mesoderm / Q000648:ultrastructure; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000648:ultrastructure; D018321:Neurothekeoma / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D016708:Synaptophysin / Q000032:analysis; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin; D014746:Vimentin; D010751:Phosphopyruvate Hydratase