Recurrent empty follicle syndrome successfully treated with recombinant human chorionic gonadotrophin.
We report a case of a patient with polycystic ovary syndrome and primary infertility who was admitted to our in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programme because of her partner's severe oligozoospermia and asthenozoospermia. Ovarian stimulation was accomplished in the three treatment cycles using gonadotrophin therapy after a dual approach with ovarian suppression using oral contraceptive pills followed by gonadotrophin-releasing hormone agonist therapy. Oocyte retrieval was unsuccessful in the first two treated cycles despite the fact that human chorionic gonadotrophin (HCG) from three different batches was used. In the third treatment cycle, recombinant HCG was used and five oocytes were retrieved. This is the first report of recurrent empty follicle syndrome despite the use of different batches of commercially available urinary HCG, and of its successful treatment using recombinant HCG.
Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine, Barcelona, Spain.
J
J
Peñarrubia
J
J
Balasch
F
F
Fábregues
M
M
Creus
S
S
Cívico
J A
JA
Vanrell
D000328:Adult; D006063:Chorionic Gonadotropin / Q000302:isolation & purification / Q000627:therapeutic use* / Q000652:urine; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D008297:Male; D009845:Oligospermia / Q000628:therapy; D006080:Ovarian Follicle / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D013577:Syndrome
D006063:Chorionic Gonadotropin; D011994:Recombinant Proteins