Control of galectin gene expression.
In this review we summarize the available information on the expression of mammalian galectins in normal and transformed cells. From all these studies it is apparent that each cell might express most of galectins; yet, during development or in various differentiation stages or under different physiological or pathological conditions, one or more galectins are preferentially expressed in each cell type. This implies a fine control of gene expression and suggests that such control should be coordinated. Nevertheless, to date very few studies have been performed on the mechanisms responsible for the regulation of galectin genes. We review the current knowledge on galectin promoter function. We believe that this area of galectin research will expand rapidly in the near future.
Centro di Endocrinologia ed Oncologia Sperimentale G. Salvatore of the Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, Università degli Studi di Napoli Federico II, Naples, Italy.
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D000818:Animals; D002460:Cell Line; D037161:Galectins; D005786:Gene Expression Regulation; D006388:Hemagglutinins / Q000235:genetics*; D006801:Humans; D014018:Tissue Distribution; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D037161:Galectins; D006388:Hemagglutinins