Cimetidine therapy for recalcitrant warts in adults: is it any better than placebo?
Three open-label, uncontrolled studies have documented successful treatment of warts with cimetidine, whereas two placebo-controlled, double-blind studies and two open-label comparative trials have failed to demonstrate efficacy. This double-blind, placebo-controlled study was designed with stringent enrollment and outcome criteria to minimize the confounding issue of spontaneous remission. Efficacy was not statistically superior to that of placebo, but a trend toward efficacy was suggested for younger subjects.
Saint Louis University School of Medicine, Missouri, USA.
C J
CJ
Rogers
M D
MD
Gibney
E C
EC
Siegfried
B R
BR
Harrison
D A
DA
Glaser
D000328:Adult; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014860:Warts / Q000188:drug therapy*
D006635:Histamine H2 Antagonists; D002927:Cimetidine