BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.
Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
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PA
Moore
O
O
Belvedere
A
A
Orr
K
K
Pieri
D W
DW
LaFleur
P
P
Feng
D
D
Soppet
M
M
Charters
R
R
Gentz
D
D
Parmelee
Y
Y
Li
O
O
Galperina
J
J
Giri
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Roschke
B
B
Nardelli
J
J
Carrell
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S
Sosnovtseva
W
W
Greenfield
S M
SM
Ruben
H S
HS
Olsen
J
J
Fikes
D M
DM
Hilbert
D000595:Amino Acid Sequence; D000818:Animals; D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D002478:Cells, Cultured; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007371:Interferon-gamma / Q000494:pharmacology; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology*; D018121:Receptors, Cytokine / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D016415:Sequence Alignment; D013045:Species Specificity; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D015854:Up-Regulation
D053264:B-Cell Activating Factor; D053265:B-Cell Activation Factor Receptor; C120197:BLyS receptor; D007136:Immunoglobulins; D008565:Membrane Proteins; D018121:Receptors, Cytokine; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins; C435926:TNFRSF13C protein, human; C505719:TNFSF13B protein, human; C486662:Tnfrsf13c protein, mouse; C505720:Tnfsf13b protein, mouse; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma