The natural history of cavernous malformations.
This article reviews general information about cavernous malformations, including histology, radiology, epidemiology, and symptomatology. Rates of hemorrhage as reported in the literature are presented. Familial cavernous malformations and their genetic basis are discussed. Finally, the variations in the biological behavior of cavernous malformations in different regions of the central nervous system are discussed and outcomes are assessed.
Department of Neurological Surgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
J L
JL
Moriarity
R E
RE
Clatterbuck
D
D
Rigamonti
D001933:Brain Stem; D016543:Central Nervous System Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D002551:Cerebral Ventricle Neoplasms / Q000145:classification / Q000503:physiopathology; D003392:Cranial Sinuses; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006392:Hemangioma, Cavernous / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome