The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.
Genomic DNA encoding for human aldehyde reductase (AKR1A1), a member of the aldo-keto reductase superfamily, was isolated and characterized. The genomic DNA is approximately 16 kb in length and contains eight exons which encode the entire coding region and the 3'-untranslated sequences. AKR1A1 was localized on chromosome 1p33-->p32 by fluorescence in situ hybridization.
Fujii
J
J
Department of Biochemistry, Osaka University Medical School, Osaka, Japan. jfujii@biochem.med.osaka-u.ac.jp
Hamaoka
R
R
Matsumoto
A
A
Fujii
T
T
Yamaguchi
Y
Y
Egashira
M
M
Miyoshi
O
O
Niikawa
N
N
Taniguchi
N
N
D020413:3' Untranslated Regions / Q000235:genetics; D000449:Aldehyde Reductase / Q000235:genetics*; D000818:Animals; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D051381:Rats
D020413:3' Untranslated Regions; C580929:AKR1A1 protein, human; D000449:Aldehyde Reductase