Safety of viral DNA in biological products.
Data from studies of the infectivity of DNA injected directly into laboratory animals are used to estimate the potential infectivity risk of residual DNA in biological products. The potential for some novel products to contain infectious quantities of residual cellular DNA is discussed, and further study of this subject is suggested.
Office of Vaccines Research and Review, Food and Drug Administration, Bethesda, MD, USA.
P R
PR
Krause
A M
AM
Lewis
D000818:Animals; D003257:Consumer Product Safety; D004279:DNA, Viral / Q000009:adverse effects*; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors
D004279:DNA, Viral