Genetic recombination: Helicases and topoisomerases link up.
RecQ helicases and topoisomerase III are both required for genome stability, particularly to prevent 'promiscuous' genetic recombination. A recent study demonstrates that, together, these enzymes can catalyse the interlinking of plasmid DNA, and suggests a novel mechanism for the control of recombination.
Wu
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L
Imperial Cancer Research Fund Laboratories, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.
Karow
J K
JK
Hickson
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ID
D000251:Adenosine Triphosphatases / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics*; D004264:DNA Topoisomerases, Type I / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005800:Genes, Fungal / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D010641:Phenotype; D010957:Plasmids / Q000235:genetics; D053484:RecQ Helicases; D011995:Recombination, Genetic
D004268:DNA-Binding Proteins; D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; C506724:RecQ protein, E coli; D004265:DNA Helicases; D053484:RecQ Helicases; D004264:DNA Topoisomerases, Type I