A new tyrosine kinase inhibitor from the marine brown alga Stypopodium zonale.
From the lipophilic extract of the marine brown alga Stypopodium zonale (Dictyotaceae) the new terpenoid compound stypoquinonic acid (1) together with the known compounds taondiol (2) and atomaric acid (3) were isolated. The structures of all isolates were determined from their spectroscopic data, including 1- and 2-dimensional NMR methods. The new compound, 1, and atomaric acid (3), showed inhibition of tyrosine kinase (p56lck).
Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig, Germany.
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Wessels
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König
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Wright
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D000460:Chlorophyta / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D015169:Colony Count, Microbial; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D000459:Phaeophyceae / Q000737:chemistry*; D011809:Quinones / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D009281:Naphthalenes; D011809:Quinones; C120739:stypoquinonic acid; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)