Collagenase-2 and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis.
Sepper
R
R
Institute of Experimental and Clinical Medicine, Tallinn, Estonia. rsepper@tervis.ee
Prikk
K
K
Tervahartiala
T
T
Konttinen
Y T
YT
Maisi
P
P
Lópes-Otín
C
C
Sorsa
T
T
D000293:Adolescent; D000328:Adult; D001987:Bronchiectasis / Q000097:blood / Q000201:enzymology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D018093:Gelatinases / Q000037:antagonists & inhibitors*; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000503:physiopathology; D008297:Male; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D008875:Middle Aged; D012016:Reference Values
D061965:Matrix Metalloproteinase Inhibitors; D018093:Gelatinases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D004318:Doxycycline