Red-man syndrome after vancomycin: potential cross-reactivity with teicoplanin.
We report a patient with infective endocarditis who developed a severe form of Red-man syndrome after vancomycin. On substituting the antibiotic to teicoplanin, the patient went on to develop a dramatic pyrexia which settled only after the teicoplanin was discontinued. This suggested that there may be an element of cross-reactivity between teicoplanin and vancomycin in such patients and that teicoplanin may not be the most appropriate substitute in all cases of vancomycin-induced Red-man syndrome.
Cardiothoracic Division, South Cleveland Hospital, Middlesbrough, UK.
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Khurana
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de Belder
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003429:Cross Reactions; D003873:Dermatitis, Exfoliative / Q000139:chemically induced; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced; D008297:Male; D017334:Teicoplanin / Q000009:adverse effects*; D014640:Vancomycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D014640:Vancomycin