Regulation of the intestinal epithelial paracellular barrier.
Paracellular transport of orally-administered drugs, the passage of molecules between adjacent intestinal epithelial cells, is impeded by a range of structural and functional features found in the intestine. An increased knowledge of the mechanisms that govern the paracellular barrier will enable the pharmaceutical scientist to design novel and rational formulations and delivery platforms that will improve the oral bioavailability of therapeutic molecules, particularly proteins and peptides, which would be taken-up by the paracellular pathway.
Drug Delivery/Biology Group, Department of Pharmaceutical Research and Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
AL
Daugherty
RJ
Mrsny