Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes.
A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.
Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
H S
HS
Kim
Y
Y
Shibata
Y
Y
Wataya
K
K
Tsuchiya
A
A
Masuyama
M
M
Nojima
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D008288:Malaria / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010545:Peroxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010962:Plasmodium berghei; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D010545:Peroxides