[Squamous metaplasia of bulbar conjunctiva in the course of long-term topical antiglaucoma therapy].
OBJECTIVE
The aim of this study was to determine how long-term topical antiglaucoma treatment affects the bulbar conjunctiva.


METHODS
59 glaucoma patients and 30 healthy people were examined by the use of impression cytology for changes in bulbar conjunctiva. Patients with glaucoma were on stable regimen of one or two antiglaucoma drugs for a minimum 1 year.


RESULTS
Squamous metaplasia of bulbar conjunctiva was found in 26.6% of patients treated with beta-blocker alone for 1-2 years and in 42.8% of patients treated with this drug for longer than 2 years. Similar changes were found in patients treated with beta-blocker with miotic--in 60% people who were on stable regimen for 1-2 years and in 70% treated longer than 2 years. No conjunctival changes were observed in healthy people.


CONCLUSIONS
Long-term topical antiglaucoma medication may produce squamous metaplasia of bulbar conjunctiva.
Wróblewska
E
E
II Kliniki Okulistyki AM w Lublinie.
D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003230:Conjunctival Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D000319:Adrenergic beta-Antagonists
Metaplazja płaskonabłonkowa spojówki gałkowej w przebiegu długotrwałego stosowania leków przeciwjaskrowych.