[The Pneumococcus Observatory of the Central Region, from June 1, 1997 to May 31, 1998].
714 pneumococcus were listed from 14 laboratories between the 1 June 1997 and the 31 May 1998. Data capture was done on Epi info software and concerned age, file number, consultation/hospitalization, sample type, susceptibility to oxacilline (5 micrograms), the results of the E-test for penicillin G, amoxicillin, cefotaxime and the results of the routine disk diffusion susceptibility method. Strains with reduced susceptibility to penicillin G (PRSP) were collected by the coordinating center to perform MICs by the reference method of agar dilution and serotyping. Over 714 strains, 45.7% of the samples originated from lungs, followed by 22% for blood samples, 14% for ear pus and 2.3% for CSF. 34% of the patients were female. 36.7% were children under 16 (57.8% PRSP) and 63.3% were adults (41% PRSP). 338 strains (47.3%) were determined as PRSP and 293 of them were studied by the coordinating center. 81 of the 293 PRSP (27.7%) were resistant et 212 (72.3%) were intermediate to penicillin G. 81% of the PRSP studied had a CMI value for penicillin G within +/- 1 log2 dilution. 20 strains of PRSP were resistant for amoxicillin (6.8% of the PRSP) and two (0.7% of the PRSP) for cefotaxime. 289 serotyping were done, most met serotypes were 23 (25%), 14 (23%). The least met was 15 (2.4%). These results let assess the epidemiology of pneumococcus in our region.
Laboratoire de Microbiologie, CHU Bretonneau, Tours, France.
B
B
Cattier
D
D
Lecocq
R
R
Levillain
J
J
Akli
E
E
Borderon
M
M
Cahiez
J
J
Carbonnelle
J C
JC
Cartron
E
E
Durieux
M
M
Gavignet
J L
JL
Graveron
P
P
Harriau
A
A
Lapointe
P
P
Laudat
J
J
Loulergue
A
A
Secher
R
R
Quentin
D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology*; D002648:Child; D005260:Female; D005602:France; D006801:Humans; D007753:Laboratories; D008297:Male; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D010400:Penicillin G / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000382:microbiology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
D000658:Amoxicillin; D002439:Cefotaxime; D010400:Penicillin G; D010068:Oxacillin
Observatoire du pneumocoque de la région Centre, du 1er juin 1997 au 31 mai 1998.