Synthesis and evaluation of 1-position-modified inositol 1,4,5-trisphosphate analogs.
IP3 analogs were synthesized by the modification of phosphate at the 1-position, and their affinity for the IP3 receptor was analyzed by means of surface plasmon resonance measurements. Our results suggest that a hydrophobic and charged moiety linked to this position enhances the affinity for the IP3 receptor.
Graduate School of Pharmaceutical Science, The University of Tokyo, Department of Pharmacology, Japan.
T
T
Inoue
K
K
Kikuchi
K
K
Hirose
M
M
Iino
T
T
Nagano
D001667:Binding, Competitive; D015220:Calcium Channels / Q000378:metabolism; D003001:Cloning, Molecular; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors; D015394:Molecular Structure; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D020349:Surface Plasmon Resonance
D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate