Mutations of the cationic trypsinogen gene in patients with chronic pancreatitis.
Nine out of 48 (19%) patients referred to a pancreatic clinic with a presumed diagnosis of idiopathic chronic pancreatitis have been shown to have mutations in the cationic trypsinogen gene (PRSSI), consistent with a previously unsuspected diagnosis of hereditary pancreatitis.
Creighton
J
J
Lyall
R
R
Wilson
D I
DI
Curtis
A
A
Charnley
R
R
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002908:Chronic Disease; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D006801:Humans; D010195:Pancreatitis / Q000175:diagnosis / Q000235:genetics*; D019512:Pancreatitis, Alcoholic / Q000175:diagnosis / Q000235:genetics; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D014362:Trypsinogen / Q000235:genetics*
D014362:Trypsinogen