Incidence and outcome of a 10-fold indomethacin overdose in premature infants.
We reviewed the incidence and morbidity of a 10-fold medication error among all premature infants treated with indomethacin. We detected 4 incidents among 1059 indomethacin doses given to infants weighing less than 1000 g. None of the infants had intracranial hemorrhage, necrotizing enterocolitis, or significant deterioration of renal function.
Narayanan
M
M
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, 94143-0544, USA.
Schlueter
M
M
Clyman
R I
RI
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D001997:Bronchopulmonary Dysplasia / Q000139:chemically induced; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D020345:Enterocolitis, Necrotizing / Q000139:chemically induced; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000506:poisoning*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data*; D012189:Retrospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin