Probucol suppresses ICAM-1 expression in rat mesangial cells: possible role of IL-1.
Interleukin-1 (IL-1) participates in the progression of glomerulonephritis by up-regulating intercellular adhesion molecule-1 (ICAM-1) expression in experimental glomerulonephritis. Probucol, an anti-hyperlipidemic agent, ameliorates some types of glomerulonephritis regardless of serum cholesterol levels, and is also reported to inhibit IL-1 release from macrophages in atherosclerotic lesions. However, little is known about the mechanism of this favorable action on glomerular injury. We examined whether or not probucol inhibits ICAM-1 expression by suppression of IL-1 action in cultured rat mesangial cells. In this brief report, we review the actions of probucol on IL-1 secretion and discuss the possible mechanism by which probucol may suppress the glomerular injury.
First Department of Medicine, Osaka University School of Medicine, Osaka National Hospital, Japan. sugiura@medone.med.osaka-u.ac.jp
T
T
Sugiura
A
A
Wada
T
T
Moriyama
M
M
Horio
N
N
Ueda
E
E
Imai
M
M
Hori
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D005786:Gene Expression Regulation; D005920:Glomerular Mesangium / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects* / Q000235:genetics; D007375:Interleukin-1 / Q000502:physiology; D011341:Probucol / Q000494:pharmacology*; D051381:Rats
D000924:Anticholesteremic Agents; D007375:Interleukin-1; D018799:Intercellular Adhesion Molecule-1; D011341:Probucol