[Progress in the treatment of colorectal cancer].
The chemotherapeutic management of advanced colorectal cancer has been a challenge to oncologists for the last 30 years, with 5-fluorouracil (5-FU) being used as the core drug. However, its effectiveness is far from satisfactory, and there has been no evidence of improved survival. Recently, a method of biochemical modulation was used to enhance the effect of 5-FU. In colorectal cancer patients with recurrent or metastatic sites, survival was significantly prolonged for a group receiving LV.5-FU therapy, based on biochemical modulation, compared with a group receiving no chemotherapy (best supportive care). Still more, LV.5-FU therapy was proved to be beneficial for survival when it was used as a postoperative adjuvant. In this way, the most recent chemotherapy for colorectal cancer was proved to be effective.
Dept. of Chemotherapy, Tokyo Metropolitan Komagome Hospital.
T
T
Sasaki
Y
Y
Maeda
T
T
Kobayashi
Y
Y
Omuro
N
N
Takeda
T
T
Ohmuro
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D003113:Colonoscopy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis; D004724:Endoscopy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery
D007155:Immunologic Factors