[Pathophysiologic effects of nitric oxide (NO) and endothelin-1 in global cerebral ischemia in an animal model--an overview].
These studies were performed in an attempt to clarify some of the pathophysiologic mechanisms which occur during and after global ischemia. Both nitric oxide and endothelin were demonstrated in gerbils to participate in responses to ischemia. It was shown that endogenous nitric oxide influences early postischemic reperfusion, systemic blood pressure and postischemic dopamine metabolism. Furthermore, the results indicated that nitric oxide played a role in dopamine release and that preischemic intracerebral nitric oxide formation significantly decreased ischemic dopamine release. In addition, ischemic release of endothelin-1 was detected; participation of nitric oxide in this release was observed. Further indication of functional interactions between nitric oxide and endothelin-1 in postischemic reperfusion were indicated by observations that endothelin-1 antagonists inhibited early hypoperfusion caused by Nitro-L-arginin and late hypoperfusion caused by endogenous endothelin-1. Nitric oxide was shown to decrease edema formation during the early postischemic period but contribute to edema formation during the late postischemic period. The findings indicate the importance of nitric oxide in stroke and ischemia.
Abteilung für Experimentelle Gerontologie, VMU Wien, Austria.
A
A
Strasser
Y
Y
Yasuma
D B
DB
Stanimirovic
R M
RM
McCarron
M
M
Spatz
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000503:physiopathology; D001929:Brain Edema / Q000503:physiopathology; D002544:Cerebral Infarction / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D019332:Endothelin-1 / Q000502:physiology*; D005849:Gerbillinae; D009569:Nitric Oxide / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology
D019332:Endothelin-1; D009569:Nitric Oxide; D004298:Dopamine
Pathophysiologische Effekte von Stickoxid (NO) und Endothelin-1 bei globaler zerebraler Ischämie im Tiermodell--ein Uberblick.