Lichenoid cutaneous drug reaction at injection sites of granulocyte colony-stimulating factor (Filgrastim).
Colony-stimulating factors are widely used for bone marrow recovery after chemotherapy. Various cutaneous side-effects have been described in most cases involving neutrophils. We report the first case of lichenoid reaction at injection sites of granulocyte colony-stimulating factor (G-CSF) in a 40-year-old patient treated for breast cancer. The eruption cleared after drug withdrawal, no recurrence was observed after drug replacement by granulocyte-macrophage colony-stimulating factor. Mainly lymphocyte-mediated lichenoid eruption to G-CSF was shown. Cutaneous side-effects to G-CSF do not share unequivocal pathogeny based on stimulation of neutrophils.
Dermatology Unit, Hôtel-Dieu, Lyon, France.
A M
AM
Viallard
A
A
Lavenue
B
B
Balme
B
B
Pincemaille
D
D
Raudrant
L
L
Thomas
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D017512:Lichenoid Eruptions / Q000139:chemically induced*; D011994:Recombinant Proteins; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim