Effect of bacillus of Calmette-Guérin, avridine and Propionibacterium acnes as immunomodulators on rabies in mice.
The cellular and humoral immune responses of mice inoculated with rabies virus and treated with the Bacillus of Calmette-Guérin, Avridine and Propionibacterium acnes were evaluated in this paper. There was a higher percentage of surviving mice in groups submitted to P. acnes treatment. Lower levels of interferon-gamma (IFN-gamma) were found in infected mice. The intra-pad inoculation test (IPI) was not effective to detect cellular immune response, contrary to the results found in MIF reaction. The survival of mice did not present correlation with the levels of antirabies serum neutralizing (SN) antibodies titers, IFN-gamma concentration and MIF response.
Megid
J
J
Department of Veterinary Hygiene and Public Health, FMVZ-UNESP, Botucatu, Brazil. JANE@FMVZ.UNESP.BR
Peraçoli
M T
MT
Curi
P R
PR
Zanetti
C R
CR
Cabrera
W H
WH
Vassao
R
R
Ito
F H
FH
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine / Q000276:immunology / Q000494:pharmacology*; D003959:Diamines / Q000276:immunology / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007371:Interferon-gamma / Q000032:analysis; D051379:Mice; D011425:Propionibacterium acnes / Q000276:immunology*; D011818:Rabies / Q000276:immunology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D003959:Diamines; D007371:Interferon-gamma; C006270:avridine