Interaction of bradykinin with angiotensin, prostacyclin, and nitric oxide in myocardial preservation.
This review focuses on the importance of bradykinin in myocardial preservation during ischemic arrest. Bradykinin is released from the heart spontaneously in response to ischemic stress, which may be viewed as a survival signal of the heart against ischemia. Bradykinin appears to function as a signaling molecule by controlling the release of other intracellular modulators, such as prostacyclins and nitric oxide, which also exert beneficial effects on the ischemic myocardium.
Sato
M
M
Department of Surgery, University of Connecticut School of Medicine, Farmington 06030, USA.
Das
D K
DK
Engelman
R M
RM
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001920:Bradykinin / Q000502:physiology*; D011464:Epoprostenol / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009926:Organ Preservation; D015398:Signal Transduction / Q000502:physiology
D000804:Angiotensin II; D009569:Nitric Oxide; D011464:Epoprostenol; D001920:Bradykinin