Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry.
Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.
Silva
CM
Faculdade de Ciências da Universidade de Lisboa, Departamento de Química e Bioquímica, Bloco C1, Piso 5, Campo Grande, 1749-016 Lisboa, Portugal.
Duarte
MF
Mira
ML
Florêncio
MH
Versluis
K
Heck
AJ