Search for antifungal and anticancer compounds from native plant species of Cerrado and Atlantic Forest.
Bioactivity-guided fractionation of several bioactive extracts obtained from Cerrado and Atlantic Forest plant species led to the isolation of potent DNA-damaging piperidine 1-5 and guanidine alkaloids 6-9 from Cassia leptophylla and Pterogyne nitens respectively, two common Leguminosae from Atlantic Forest. By means of biotechnological approach on Maytenus aquifolium, a species from Cerrado, moderate DNA-damaging sesquiterpene pyridine alkaloid 10-11 was isolated. Bioassay-guided fractionation on Casearia sylvestris, a medicinal plant species found in Cerrado and Atlantic Forest, led to the isolation of clerodane diterpenes 12-13 which showed effect on DNA. In addition, we have reported several interesting potent antifungal iridoids: 1 beta-hydroxy-dihydrocornin (14), 1 alpha-hydroxy-dihydrocornin (15), alpha-gardiol (16), beta-gardiol (17), plumericin (18), isoplumericin (19), 11-O-trans-caffeoylteucrein (20); ester derivative: 2-methyl-4-hydroxy-butyl-caffeoate (21), amide N-[7-(3',4'-methylenedioxyphenyl)-2Z, 4Z-heptadienoyl] pyrrolidine (22) and triterpene viburgenin (23).
Instituto de Química, Universidade Estadual Paulista, Araraquara, SP. bolzaniv@iq.unesp.br
V da S
Vda S
Bolzani
M C
MC
Young
M
M
Furlan
A J
AJ
Cavalheiro
A R
AR
Araújo
D H
DH
Silva
M N
MN
Lopes
D000935:Antifungal Agents / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D001938:Brazil; D004249:DNA Damage; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts