Synthesis of N-desmethyl derivatives of 17alpha-acetoxy-11beta-(4-N,N-dimethylaminophenyl)-19-norpregna-4,9-die ne-3,20-dione and mifepristone1: substrates for the synthesis of radioligands.
The syntheses of N-desmethyl derivatives of CDB-2914 and the mono-N-desmethyl derivative of Mifepristone are described. We also describe the use of the mono-desmethyl derivatives as substrates for the synthesis of N-tritomethyl derivatives of CDB-2914 and Mifepristone with high specific activity (ca. 80 Ci/mmol), which serve as radioligands for radioimmunoassay.
Department of Organic Chemistry, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
P N
PN
Rao
C K
CK
Acosta
J W
JW
Cessac
M L
ML
Bahr
H K
HK
Kim
D009682:Magnetic Resonance Spectroscopy; D015735:Mifepristone / Q000138:chemical synthesis* / Q000737:chemistry; D009649:Norpregnadienes / Q000138:chemical synthesis* / Q000737:chemistry; D011863:Radioimmunoassay; D011869:Radioligand Assay
D009649:Norpregnadienes; D015735:Mifepristone; C094854:ulipristal