Multifocal intraocular malignant melanoma: report of two cases and review of the literature.
OBJECTIVE
To describe two eyes from two patients with multifocal primary intraocular melanoma.


METHODS
Two case reports.


METHODS
The history and histologic findings in the enucleated eyes of two patients with multifocal intraocular melanoma are described in comparison to previously reported cases.


METHODS
Pathologic examination of enucleated eyes.


RESULTS
One of the two eyes contained mixed cell type melanomas, and one eye contained spindle cell type melanomas. Examination of serial sections showed no continuity between the intraocular melanomas. There were no associated ocular or systemic conditions with the multifocal intraocular melanomas.


CONCLUSIONS
Multifocal primary intraocular melanoma is rare. There is no known predisposing factor to this condition.
Dithmar
S
S
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Völcker
H E
HE
Grossniklaus
H E
HE
D000368:Aged; D002830:Choroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D002924:Ciliary Body / Q000000981:diagnostic imaging / Q000473:pathology; D015353:Eye Enucleation; D006801:Humans; D015811:Iris Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography; D014604:Uveal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*