On the role of feedback in promoting conflicting goals of the adaptive immune system.
We explored here the implications of two premises. 1) In their response over days or weeks to pathogen invasion, cells of the immune system combine several overlapping and perhaps contradictory goals. 2) The immune system has ways to monitor progress toward these goals via receptors that bind chemicals whose concentrations are related to such progress. We illustrate with simple mathematical models how such monitoring can lead to feedbacks that improve the efficiency of a given effector type in accomplishing its specialized task, and also how feedbacks can shift the balance among a variety of effectors toward a preponderance of the more effective. Specific suggestions are given for feedback molecules.
Segel
L A
LA
Department of Computer Science and Applied Mathematics, The Weizmann Institute of Science, Rehovot, Israel. lee@wisdom.weizmann.ac.il
Bar-Or
R L
RL
D000818:Animals; D005246:Feedback; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D018448:Models, Immunological; D008962:Models, Theoretical