[Occupational N-hexane neuropathy: clinical and neurophysiological investigation].
A group of 37 patients (26 men and 11 women), aged 18-49 (mean: 29.7) with subacute toxic polyneuropathy was investigated clinically and electrophysiologically. In all cases the disease was induced by occupational exposure to n-hexane in a small enterprise of purse makers. Toxicological investigations revealed a highly increased concentration of n-hexane in glue used in the manufacture process. The clinical course, including delayed worsening of symptoms after cessation of exposure, was typical when compared with previously reported cases of n-hexan-induced neuropathy after glue sniffing and industrial exposure. Electroneurographic (ENeG) studies showed a predominately decreased motor nerve conduction velocity (MNCV) with focal conduction block followed by dramatically diminished CMAPs. Recovery of EneG abnormalities paralled the clinical improvement.
Przychodni Chorób Zawodowych Instytutu Medycyny Pracy im. prof. dra med. Jerzego Nofera w Lodzi Kierownik.
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Głuszcz-Zielińska
D000208:Acute Disease; D000269:Adhesives / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D004576:Electromyography; D005260:Female; D006586:Hexanes / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000187:drug effects / Q000503:physiopathology*; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D013497:Sural Nerve / Q000187:drug effects / Q000503:physiopathology*
D000269:Adhesives; D006586:Hexanes; C026385:n-hexane
Zawodowa toksyczna polineuropatia po narazeniu na n-heksan--obserwacja kliniczna i elektrofizjologiczna.