Invasive group B streptococcal disease in nonpregnant adults.
Forty episodes of invasive group B streptococcal infections in nonpregnant adults at Chris Hani Baragwanath Hospital, Soweto, South Africa, were retrospectively reviewed. The mean age of the patients was 45.6 years. Twenty (50%) patients were bacteraemic. Common predisposing conditions included diabetes mellitus (27.5%), trauma (25%), and HIV infection (12.5%). Soft tissue abscesses and pneumonia accounted for 70% of the presentations. Ten (25%) patients had acquired the infection nosocomially. Death occurred in 14 (35%) patients and was significantly associated with bacteraemia (P = 0.0009) and pneumonia (P = 0.0012). Trauma is an important predisposing condition, and HIV infection may have played a role in the setting described; both factors probably accounted for the relatively young age of the patients.
Department of Clinical Microbiology and Infectious Diseases, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa.
O
O
Perovic
H H
HH
Crewe-Brown
M
M
Khoosal
A S
AS
Karstaedt
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000401:mortality / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D013290:Streptococcal Infections / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*; D013292:Streptococcus agalactiae; D014947:Wounds and Injuries / Q000150:complications