A new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia.
The dichloromethane extract of the stem of jacaranda filicifolia Don. showed inhibitory activity in vitro against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2 alpha, 3 alpha-dihydroxyurs-12-en-28-oic acid, beta-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.
Ali
R M
RM
Houghton
P J
PJ
D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018547:Plant Stems; D010946:Plants, Medicinal; D013228:Stearates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C120645:2-(4-hydroxyphenyl)ethyl-1-dodecyloctadecanoate; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D013228:Stearates