[Effect of protoporphyrin on digestive tract absorption of dioxins in rats].
This paper presents the fecal excretion of polychlorinated dibenzo-p-dioxin (PCDD) congeners, and polychlorinated dibenzofuran (PCDF) congeners in male rats fed a diet containing 0.5% disodiumprotoporphyrin (PPNa) or 0.5% hemin. The animals were administered 4 g of 0.5% PPNa or 0.5% hemin diet containing 0.5 ml of the causal rice-bran oil of Yusho that had occurred in the Southwest part of Japan in 1968 and kept on the same diet for five days. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with 0.5% PPNa were 2.1 and 1.9 times higher, respectively, than that in the group fed with a control diet. Hemin did not show any significant effect on the inhibition of absorption of dioxins. Next, the rats were given a diet containing 0.5% PPNa or 0.5% Hemin for four weeks after a week interval from the day of the causal rice-bran oil administration. The fecal excretion of 2,3,7,8-T4CDD and 2,3,4,7,8-P5CDF in the group fed with 0.5% PPNa were stimulated 2.1 times higher, respectively, than that in the group fed with a control diet. Hemin did not show any significant effect on the inhibition of re-absorption of dioxins.
Fukuoka Institute of Health and Environmental Sciences, Japan.
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Morita
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Matsueda
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Iida
D000818:Animals; D001572:Benzofurans / Q000032:analysis / Q000493:pharmacokinetics*; D003864:Depression, Chemical; D005243:Feces / Q000737:chemistry; D005506:Food Contamination; D006427:Hemin / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D012275:Oryza; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D011108:Polymers / Q000032:analysis / Q000493:pharmacokinetics*; D011524:Protoporphyrins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012989:Soil Pollutants / Q000032:analysis / Q000493:pharmacokinetics*
D001572:Benzofurans; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; D011524:Protoporphyrins; D012989:Soil Pollutants; C016068:polychlorodibenzofuran; D006427:Hemin