Muscle and skin sympathetic nerve traffic during the "white-coat" effect.
BACKGROUND
Sphygmomanometric blood pressure measurements induce an alerting reaction and thus an increase in the patient's blood pressure and heart rate. Whether and to what extent this "white-coat" effect is accompanied by detectable changes in sympathetic nerve traffic has never been investigated.


RESULTS
In 10 mild untreated essential hypertensives (age 37.9+/-3. 8 years, mean+/-SEM), we measured arterial blood pressure (by Finapres), heart rate (by ECG), and postganglionic muscle and skin sympathetic nerve activity via microneurography. Measurements were performed with the subject supine during (1) a 15-minute control period, (2) a 10-minute visit by a doctor unfamiliar to the patient who was in charge of measuring his or her blood pressure by sphygmomanometry, and (3) a 15-minute recovery period after the doctor's departure. The entire procedure was performed twice at a 45-minute interval to obtain, in separate periods, muscle or skin sympathetic nerve traffic recordings, whose sequence was randomized. The doctor's visit induced a sudden, marked, and prolonged pressor and tachycardic response, accompanied by a significant increase in skin sympathetic nerve traffic (+38.6+/-6.7%, P<0.01). In contrast, muscle sympathetic nerve traffic was significantly inhibited (-25. 5+/-4.1%, P<0.01). All changes persisted throughout the doctor's visit and, with the exception of skin sympathetic nerve traffic, showed a slow rate of disappearance after the doctor's departure.


CONCLUSIONS
Thus, the pressor and tachycardic responses to the alerting reaction that accompanies sphygmomanometric blood pressure measurement is characterized by a behavior of the adrenergic nervous system that causes muscle sympathoinhibition and skin sympathoexcitation.
Grassi
G
G
Cattedra di Medicina Interna, Università di Milano, Ospedale S. Gerardo, Monza, and Centro di Fisiologia Clinica e Ipertensione, IRCCS, Milano, Italy.
Turri
C
C
Vailati
S
S
Dell'Oro
R
R
Mancia
G
G
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D004594:Electrophysiology; D006339:Heart Rate; D006801:Humans; D009132:Muscles / Q000294:innervation*; D012867:Skin / Q000294:innervation*; D019722:Sphygmomanometers; D013564:Sympathetic Nervous System / Q000502:physiology*