Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China.
IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barré syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barré syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti-GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.
Yuki
N
N
Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan. n_yuki@msn.com
Ho
T W
TW
Tagawa
Y
Y
Koga
M
M
Li
C Y
CY
Hirata
K
K
Griffin
J W
JW
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001369:Axons / Q000473:pathology; D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000276:immunology* / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000276:immunology
D001323:Autoantibodies; D005732:Gangliosides; D005677:G(M1) Ganglioside; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a