Heparan sulfate and cell division.
Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic transformation. Several lines of experimental evidence suggest that heparan sulfate plays a role in cellular recognition, cellular adhesion and growth control. Heparan sulfate can participate in the process of cell division in two distinct ways, either as a positive or negative modulator of cellular proliferation, or as a response to a mitogenic stimulus.
Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brasil. marimelia.bioq@epm.br
M A
MA
Porcionatto
H B
HB
Nader
C P
CP
Dietrich
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D006133:Growth Substances; D019812:Heparan Sulfate Proteoglycans / Q000096:biosynthesis / Q000502:physiology; D006497:Heparan Sulfate / Q000096:biosynthesis / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor
D006133:Growth Substances; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D011493:Protein Kinase C; D017468:Receptors, Fibroblast Growth Factor