Residual strain in ischemic ventricular myocardium.
Structural remodeling during acute myocardial infarction affects ventricular wall stress and strain. To see whether acute myocardial infarction alters residual stress and strain in the left ventricle (LV), we measured opening angles in rat hearts after 30 minutes of left coronary artery occlusion. The mean opening angle in 18 ischemic hearts (51 +/- 20 deg) was significantly greater than in five sham-operated controls (29 +/- 11 deg, P < 0.05). To determine whether these alterations in residual strain may be associated with strain softening caused by systolic overstretch of the noncontracting ischemic tissue, we also measured opening angles in isolated hearts that had been passively inflated to high LV pressures (120 mmHg). The mean opening angle of the strain-softened hearts was not significantly different from the sham-operated hearts (34 +/- 27 deg, P = 0.74). Mean collagen area fractions in the myocardium were not significantly different between ischemic hearts (0.027 +/- 0.014) and the nonischemic group (0.022 +/- 0.011). Although there were significant differences in opening angles measured with ischemia, they do not appear to be a result of altered extracellular collagen content or softening associated with overstretch. Thus, there is a significant change in residual strain associated with acute ischemia that may be related to changes in collagen fiber structure, myocyte structure, or metabolic state.
Department of Bioengineering, Institute of Biomedical Engineering, University of California, San Diego, La Jolla 92093-0412, USA.
S R
SR
Summerour
J L
JL
Emery
B
B
Fazeli
J H
JH
Omens
A D
AD
McCulloch
D000818:Animals; D003094:Collagen / Q000032:analysis; D004195:Disease Models, Animal; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D017725:Ventricular Pressure; D020257:Ventricular Remodeling
D003094:Collagen