[An ileal ulcer and diaphragm-type colonic stenosis due to diclofenac].
Nonsteroidal anti-inflammatory drugs (NSAID) are used extensively in the general population. It's well known the adverse effects of NSAID over the upper gastrointestinal tract and small intestine. Enteric-coated and slow release preparations were created in order to prevent those effects. We describe a woman case who took diclofenac for many years and developed both ileal ulceration and diaphragm-like colonic structure. Lesions in lower gastrointestinal tract were infrequent but severe; the lesion were seen on colonoscopy but not on barium studies; the physiopathology of these lesions remains uncertain; and the most efficacy attitude is the suppression of diclofenac.
Servicio de Medicina Interna, Hospital Universitario Virgen del Rocío, Sevilla.
A
A
Aguirre Palacio
M
M
Romero Gómez
A
A
Grilo Reina
E
E
Rafel Ribas
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002908:Chronic Disease; D003106:Colon / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D007082:Ileum / Q000187:drug effects / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000187:drug effects / Q000648:ultrastructure; D008875:Middle Aged; D014456:Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac
Ulcera ileal y estenosis colónica tipo diafragma por diclofenaco.