TCR specificity in infection induced granulomas.
Granuloma formation is an essential host response to many intracellular pathogens and some particulate antigens. T lymphocytes, especially CD4+ T-cells, are required for the initial formation and ongoing maintenance of the inflammatory response. In the absence of CD4+ T-cells, most infections which normally provoke a granulomatous response are more widely disseminated or lethal since the protective lesions are either malformed or absent. The role of T-cell receptor mediated antigen specificity in infectious states is reviewed with a special emphasis upon recent work on S. mansoni induced granulomas.
Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53706, USA.
L H
LH
Hogan
J V
JV
Weinstock
M
M
Sandor
D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000378:metabolism*; D006099:Granuloma / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000150:complications / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D018984:Epitopes, T-Lymphocyte; D011948:Receptors, Antigen, T-Cell