Early age of onset, brain morphological changes and non-consistent motor asymmetry in schizophrenic patients.
Previous data suggest abnormalities in the consistence of motor dominance in schizophrenia (e.g. mixed-handedness, poor correlation between hand, eye and foot preferences and an increase of hand-eye crossed dominance). The aim of this work is to examine the clinical significance of hand-eye and hand-foot crossed dominance in a sample of 61 right-handed schizophrenic patients. The application of multivariate analysis revealed that 23 right-handed and non-right-eyed patients (crossed hand-eye dominant group) had a significant earlier clinical onset and smaller brain size, global and frontal area, than 38 right-handed and right-eyed schizophrenics (consistent hand-eye dominance group). These findings are discussed within the context of neurodevelopmental disorders.
Department of Medicine, University of Valencia, Spain. rafael.tabares@uv.es
R T
RT
Seisdedos
J S
JS
Arias
M
M
Gómez-Beneyto
C L
CL
Cercós
D000328:Adult; D000367:Age Factors; D001921:Brain / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D011596:Psychomotor Disorders / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology*