Myoepithelium in salivary and mammary neoplasms is host-friendly.
This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.
Division of Pathology and Laboratory Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.
J G
JG
Batsakis
A K
AK
el-Naggar
D000230:Adenocarcinoma / Q000473:pathology* / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002277:Carcinoma / Q000473:pathology* / Q000648:ultrastructure; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000648:ultrastructure; D002455:Cell Division; D004273:DNA, Neoplasm; D006801:Humans; D008940:Mitotic Index; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure
D004273:DNA, Neoplasm