Jatrophane diterpenoids from Euphorbia peplus.
From the pro-inflammatory active extract of Euphorbia peplus, a new diterpene polyester (1) based on the jatrophane skeleton was isolated together with the known compounds 2-5. The irritant activities of some jatrophane diterpenes (2, 3 and 6-9) were also investigated: only compound 2 was found to exert a weak pro-inflammatory activity on mouse ear.
Hohmann
J
J
Department of Pharmacognosy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Vasas
A
A
Günther
G
G
Dombi
G
G
Blazsó
G
G
Falkay
G
G
Máthé
I
I
Jerkovich
G
G
D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D004423:Ear; D007509:Irritants / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity
D004224:Diterpenes; D007509:Irritants; D010936:Plant Extracts