Oral plasmablastic lymphoma in previously undiagnosed HIV disease.
Non-Hodgkin's lymphoma is the second most common HIV-associated malignancy. This report details a case of the recently described entity plasmablastic lymphoma of the mouth in a patient who was later found to have severe HIV disease. The tumor manifested as a large ulcerated mass of the left maxillary alveolus, causing bony destruction and tooth mobility. Histologic examination of lesional tissue revealed a lymphoid tumor with a high proliferation rate containing lymphoplasmacytoid cells that were reactive to the plasma cell marker VS38c but not to CD20 or CD79a; these are features of the recently reported non-Hodgkin's lymphoma termed plasmablastic lymphoma. This is only the second report of an unusual tumor that has a predilection for the orofacial tissues.
Porter
S R
SR
Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, University of London, United Kingdom.
Diz Dios
P
P
Kumar
N
N
Stock
C
C
Barrett
A W
AW
Scully
C
C
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D019070:Cell Lineage; D003937:Diagnosis, Differential; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D016483:Lymphoma, AIDS-Related / Q000276:immunology / Q000473:pathology*; D008297:Male; D008441:Maxillary Neoplasms / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017493:Leukocyte Common Antigens