Effects of neutral sodium hydrogen phosphate on setting reaction and mechanical strength of hydroxyapatite putty.
The setting reaction and mechanical strength in terms of diametral tensile strength (DTS) of hydroxyapatite (HAP) putty made of tetracalcium phosphate, dicalcium phosphate anhydrous, and neutral sodium hydrogen phosphate (Na1.8H1.2PO4) solution containing 8 wt % sodium alginate were evaluated as a function of the Na1.8H1.2PO4 concentration. In one condition, HAP putty was placed in an incubator kept at 37 degrees C and 100% relative humidity. In the other condition, immediately after mixing HAP putty was immersed in serum kept at 37 degrees C. Longer setting times and lower DTS values were observed when HAP putty was immersed in serum regardless of the Na1.8H1.2PO4 concentration. The setting times of the HAP putty in both conditions became shorter with an increase in the Na1. 8H1.2PO4 concentration, reaching approximately 7-13 min when the Na1. 8H1.2PO4 concentration was 0.6 mol/L or higher. The DTS value of HAP putty was relatively constant (10 MPa) regardless of the Na1.8H1. 2PO4 concentration (0.2-1.0 mol/L) when HAP putty was kept in an incubator. In contrast, when HAP putty was immersed in serum, the DTS value was dependent on the Na1.8H1.2PO4 concentration. It increased with the Na1.8H1.2PO4 concentration and reached approximately 5 MPa when the Na1.8H1.2PO4 concentration was 0.6 mol/L, after which it showed a relatively constant DTS value. We therefore would recommend a HAP putty that uses 0.6 mol/L Na1.8H1. 2PO4 since at that concentration the putty's setting time (approximately 10 min) is proper for clinical use and it shows good DTS value (approximately 5 MPa) even when it is immersed in serum immediately after mixing.
Department of Biomaterials, Okayama University Dental School, 2-5-1 Shikata, Okayama 700-8525 Japan. kunio@dent.okayama-u.ac.jp
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K
Ishikawa
Y
Y
Miyamoto
M
M
Takechi
Y
Y
Ueyama
K
K
Suzuki
M
M
Nagayama
T
T
Matsumura
D001672:Biocompatible Materials / Q000737:chemistry*; D001769:Blood; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D009824:Ointments; D010710:Phosphates / Q000494:pharmacology*; D013314:Stress, Mechanical; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors
D001672:Biocompatible Materials; D009824:Ointments; D010710:Phosphates; D017886:Durapatite; C018279:sodium phosphate