Angiocentric lymphoma involving the temporal bone in a child.
Involvement of the temporal bone in patients with malignant lymphomas is very rare. Most of the reported cases have been clinically asymptomatic and were diagnosed only by post-mortem examinations. We present a nasal, paranasal, nasopharyngeal lymphoma that occurred in a 12-year-old child and also involved the temporal bone. Clinical presentation began with bilateral chronic otitis media. Histopathologically, tumor was found to be an angiocentric lymphoma of B-cell origin. Association with Epstein-Barr virus could not be demonstrated. Despite combination chemotherapy (with cyclophosphamide, vincristine, doksorubicine, prednisolone, L-asparaginase, cytosine arabinoside, metotraxate) and radiotherapy (to 40 Gy), disease progressed locally as well as to cervical lymph nodes and the lungs.
Cakmak
O
O
Department of Otorhinolaryngology, Hacettepe University School of Medicine, Ankara, Turkey.
Kutluk
T
T
Akyol
M U
MU
Ruacan
S
S
D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D009383:Neoplasms, Vascular Tissue / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D010033:Otitis Media / Q000175:diagnosis; D011859:Radiography; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D013701:Temporal Bone / Q000098:blood supply*