Pikuroside: a novel iridoid from Picrorhiza kurroa.
A new iridoid, pikuroside (1), was isolated from the roots of Picrorhiza kurroa, together with three known iridoids, picroside I (2), picroside II (3), and 6-feruloyl catalpol (4). The structure of 1 was established by interpretation and full assignments of NMR spectral data. Pikuroside (1) had no antiinflammatory activity, although the crude extract and picroside II (3) demonstrated moderate activity.
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Department of Natural Product Chemistry, Univera Pharmaceuticals, Inc., Broomfield, Colorado 80021, USA. qjia@upi1.com
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D001211:Asia, Western; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification* / Q000494:pharmacology; D003436:Croton Oil; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D007509:Irritants; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005960:Glucosides; D007509:Irritants; C120734:pikuroside; D003436:Croton Oil