The use of lithium clearance measurements as an estimate of glomerulo-tubular function.
Lithium clearance measurements are based on the observation that lithium undergoes isoosmotic reabsorption in the proximal renal tubule to the same extent as salt and water, but undergoes neither reabsorption nor secretion elsewhere in the nephron. Consequently, lithium clearance values estimate the delivery of isoosmotic fluid to the loop of Henle and hence provide an assessment of proximal tubular reabsorption of isoosmotic fluid. If sodium clearance and urinary flow rate are also measured, then this allows the derivation of a number of parameters relating to both the absolute and relative renal handling of isoosmotic fluid in the proximal and distal regions of the kidney. Consequently, lithium clearance techniques can be used in both experimental and clinical studies to evaluate glomerulo-tubular function and provide information regarding the handling of sodium and water by the proximal and distal nephron in both health and disease. The use of lithium clearance measurements in the assessment of glomerulo-tubular function in patients treated with rIL2 for colorectal cancer is described and its application to both drug-induced toxicity and other disease states discussed.
School of Pharmacy and Pharmaceutical Sciences, De Montfort University, Leicester, United Kingdom. pwhiting@DMU.ac.uk
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D000368:Aged; D000704:Analysis of Variance; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000378:metabolism* / Q000652:urine; D007677:Kidney Function Tests / Q000592:standards*; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000502:physiology*; D016651:Lithium Carbonate / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012680:Sensitivity and Specificity
D007376:Interleukin-2; D011994:Recombinant Proteins; D016651:Lithium Carbonate