Serotonin syndrome caused by overdose with paroxetine and moclobemide.
Well known clinical syndromes can be produced by overdose with more commonly ingested substances such as opiates or tricyclic antidepressants. A case of a much more unusual syndrome presenting to the accident and emergency department resulting from overdose with a combination of tablets is reported. The clinical presentation of serotonin syndrome and its management are described. This resulted from acute ingestion of paroxetine, a selective serotonin reuptake inhibitor, and moclobemide, a monoamine oxidase inhibitor.
Accident and Emergency Department, Northern General Hospital, Sheffield.
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FitzSimmons
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Metha
D000328:Adult; D001549:Benzamides / Q000506:poisoning*; D018572:Disease-Free Survival; D062787:Drug Overdose / Q000150:complications*; D004638:Emergency Treatment; D006801:Humans; D008297:Male; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000506:poisoning*; D017374:Paroxetine / Q000506:poisoning*; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning*; D013406:Suicide, Attempted
D001549:Benzamides; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors