Increased blood glucose and insulin, body size, and incident colorectal cancer.
BACKGROUND
Abdominal obesity--an elevated level of visceral adipose tissue--has been linked to colorectal cancer. Furthermore, elevated levels of visceral adipose tissue have been associated with hyperinsulinemia, and insulin is a growth factor in the colon. We assessed whether waist circumference, a surrogate measure of visceral adipose tissue, and metabolic parameters associated with visceral adipose tissue were related to colorectal cancer.


METHODS
In the Cardiovascular Health Study cohort, we examined the relationship of baseline measurements of body size, glucose, insulin, and lipoproteins to incident colorectal cancer. All P values are two-sided.


RESULTS
Among 5849 participants, 102 incident cases of colorectal cancer were identified. Individuals in the highest quartile of fasting glucose had a nearly twofold increased risk of colorectal cancer (relative risk [RR] = 1.8; 95% confidence interval [CI] = 1.0-3.1), and the linear trend RR (LT RR = 1.2; 95% CI = 1.0-1.5) for fasting glucose level was statistically significant (P =. 02). Glucose and insulin levels 2 hours after oral glucose challenge also exhibited statistically significant associations with colorectal cancer (2-hour glucose levels: RR = 2.4 [95% CI = 1.2-4. 7]/LT RR = 1.3 [95% CI = 1.0-1.6; P =.02]; 2-hour insulin levels: RR = 2.0 [95% CI = 1.0-3.8]/LT RR = 1.2 [95% CI = 1.0-1.5; P =.04]). Analysis of fasting insulin levels suggested a threshold effect, with values above the median associated with colorectal cancer (RR = 1.6; 95% CI = 1.1-2.4; P =.02). Higher levels of waist circumference were also statistically significantly associated with colorectal cancer (RR = 1.9; 95% CI = 1.1-3.3; P =.02).


CONCLUSIONS
These data provide, to our knowledge, the first direct evidence of an association between elevated visceral adipose tissue level, its associated metabolic effects, and colorectal cancer.
Department of Medicine and Epidemiology, University of Pittsburgh, PA, USA.
R E
RE
Schoen
C M
CM
Tangen
L H
LH
Kuller
G L
GL
Burke
M
M
Cushman
R P
RP
Tracy
A
A
Dobs
P J
PJ
Savage
D000273:Adipose Tissue; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001824:Body Constitution; D008076:Cholesterol, HDL / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007328:Insulin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012306:Risk; D014280:Triglycerides / Q000097:blood*; D014781:Viscera
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides