Heat stress proteins and myocardial protection: experimental model or potential clinical tool?
Heat stress proteins (hsp) are induced by a variety of stimuli including elevated temperature, ischaemia, hypoxia, pressure overload and some chemicals. They help to maintain the metabolic and structural integrity of the cell, as a protective response to external stresses. They are known to protect the myocardium from the damaging effects of ischaemia and reperfusion. The heat stress response results in accumulation of heat stress proteins. The beneficial effects associated with their expression include improved endothelial and mechanical recovery of the ischaemic heart. In addition, preservation of high energy phosphates and reduction in infarct size. It has also been shown that critical amounts of hsp70 are necessary to ensure protection of the myocardium. However, questions remain regarding the biochemical mechanisms underlying this protective effect. Alterations in the cell metabolism and chaperone function of cells expressing heat shock proteins, are thought to be responsible. Despite the obvious clinical benefits related to the heat stress response in a clinical setting, the application of this phenomena remains limited. Heat, both quantitatively and qualitatively is one of the best inducers of heat stress proteins. However, the effects of heat stress are nonspecific and intracellular damage is a common occurrence. The search for alternative stimuli, particularly within the fields of pharmacotherapy or genetic manipulation may offer more viable options, if the heat stress response is take its place as an established strategy for myocardial protection.
Department of Cardiothoracic Surgery, Imperial College, Harefield Hospital, Middlesex, UK.
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Gray
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Amrani
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Yacoub
D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis; D018834:Chaperonin 60 / Q000502:physiology; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000502:physiology; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones; D017202:Myocardial Ischemia / Q000517:prevention & control*; D009363:Neoplasm Proteins / Q000502:physiology; D015221:Potassium Channels / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D018834:Chaperonin 60; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C057725:HSPB1 protein, human; D006360:Heat-Shock Proteins; C486114:Hspb1 protein, rat; D018832:Molecular Chaperones; D009363:Neoplasm Proteins; D015221:Potassium Channels