Computational rules for chemotaxis in the nematode C. elegans.
We derive a linear neural network model of the chemotaxis control circuit in the nematode Caenorhabditis elegans and demonstrate that this model is capable of producing nematodelike chemotaxis. By expanding the analytic solution for the network output in time-derivatives of the network input, we extract simple computational rules that reveal how the model network controls chemotaxis. Based on these rules we find that optimized linear networks typically control chemotaxis by computing the first time-derivative of the chemical concentration and modulating the body turning rate in response to this derivative. We argue that this is consistent with behavioral studies and a plausible mechanism for at least one component of chemotaxis in real nematodes.
Ferrée
T C
TC
Electrical Geodesics, Inc., Riverfront Research Park, Eugene, OR 97403, USA.
Lockery
S R
SR
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology*; D016014:Linear Models; D008124:Locomotion / Q000502:physiology*; D008954:Models, Biological; D016571:Neural Networks, Computer; D009949:Orientation / Q000502:physiology