Chromatin remodeling and leukemia: new therapeutic paradigms.
Redner
R L
RL
Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. redner+@pitt.edu
Wang
J
J
Liu
J M
JM
D000107:Acetylation; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000502:physiology; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D015973:Gene Expression Regulation, Leukemic; D056572:Histone Deacetylase Inhibitors; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D051788:Myeloid-Lymphoid Leukemia Protein; D009363:Neoplasm Proteins / Q000502:physiology; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000648:ultrastructure; D015514:Oncogene Proteins, Fusion / Q000502:physiology; D011499:Protein Processing, Post-Translational; D011519:Proto-Oncogenes; D000075142:RUNX1 Translocation Partner 1 Protein; D011993:Recombinant Fusion Proteins / Q000502:physiology; D055672:Static Electricity; D014157:Transcription Factors / Q000502:physiology; D014178:Translocation, Genetic; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use
C107844:AML1-ETO fusion protein, human; D000970:Antineoplastic Agents; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006657:Histones; C497422:KMT2A protein, human; D009363:Neoplasm Proteins; D009707:Nucleosomes; D015514:Oncogene Proteins, Fusion; C118318:PLZF-RARalpha fusion protein, human; D000075142:RUNX1 Translocation Partner 1 Protein; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D051788:Myeloid-Lymphoid Leukemia Protein; D014212:Tretinoin; D011495:Histone-Lysine N-Methyltransferase