[Occupational N-hexane neuropathy: clinical and neurophysiological investigation].
A group of 37 patients (26 men and 11 women), aged 18-49 (mean: 29.7) with subacute toxic polyneuropathy was investigated clinically and electrophysiologically. In all cases the disease was induced by occupational exposure to n-hexane in a small enterprise of purse makers. Toxicological investigations revealed a highly increased concentration of n-hexane in glue used in the manufacture process. The clinical course, including delayed worsening of symptoms after cessation of exposure, was typical when compared with previously reported cases of n-hexan-induced neuropathy after glue sniffing and industrial exposure. Electroneurographic (ENeG) studies showed a predominately decreased motor nerve conduction velocity (MNCV) with focal conduction block followed by dramatically diminished CMAPs. Recovery of EneG abnormalities paralled the clinical improvement.
Głuszcz-Zielińska
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Przychodni Chorób Zawodowych Instytutu Medycyny Pracy im. prof. dra med. Jerzego Nofera w Lodzi Kierownik.
D000208:Acute Disease; D000269:Adhesives / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D004576:Electromyography; D005260:Female; D006586:Hexanes / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000187:drug effects / Q000503:physiopathology*; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D013497:Sural Nerve / Q000187:drug effects / Q000503:physiopathology*
D000269:Adhesives; D006586:Hexanes; C026385:n-hexane
Zawodowa toksyczna polineuropatia po narazeniu na n-heksan--obserwacja kliniczna i elektrofizjologiczna.