A comparison of the bioequivalence of 0.5% fenbendazole top dress pellets or 10% fenbendazole oral suspension against a spectrum of equine parasites.
A controlled test was conducted to assess the efficacy bioequivalence of a single dose of 0.5% fenbendazole (FBZ) top dress pellets to a 10% FBZ suspension formulation (Panacur suspension 10%, Hoechst Roussel Vet). Thirty horses with naturally-acquired parasite infections, in replicates of three, were used. Strongyle egg per gram counts were not significantly different (P>0.1) between groups pretreatment, but FBZ treated groups were significantly different from the control group post-treatment. At necropsy, which occurred seven to nine days post-treatment, two methods of nematode recovery were compared to assess whether a small aliquot can be used in a control test to determine efficacy against large as well as small strongyles. Both post mortem worm recovery techniques revealed similar efficacies of both formulations (>95%) against small and large strongyles, but large differences in the number of worms recovered. Six species of small strongyles comprised 96% of all the small strongyles recovered: Coronocyclus coronatus, Cylicocyclus insigne, Cylicostephanus longibursatus, Cylicocyclus brevicapsulatus, Cylicocyclus nassatus, and Cyathostomum catinatum. The results of this study demonstrated therapeutic bioequivalence between FBZ formulations and also the need to sample at least a 10% aliquot to accurately estimate number of large strongyles. No adverse reactions to treatment were detected.
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana 61802, USA. dhutchen@uiuc.edu
D E
DE
Hutchens
A J
AJ
Paul
J A
JA
DiPietro
T F
TF
Lock
C J
CJ
Jones
D D
DD
Rowley
R W
RW
Wallace
D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000592:standards; D002432:Cecum / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000592:standards; D006736:Horses; D007413:Intestinal Mucosa / Q000469:parasitology; D007420:Intestine, Large / Q000469:parasitology; D013319:Strongyle Infections, Equine / Q000188:drug therapy*; D013320:Strongyloidea / Q000187:drug effects; D013535:Suspensions; D013810:Therapeutic Equivalency
D000969:Antinematodal Agents; D013535:Suspensions; D005273:Fenbendazole