Synthesis of water-soluble phenytoin prodrugs.
The synthesis of novel water-soluble phenytoin derivatives, bearing an ionizable group, and a preliminary study for in vitro blood hydrolysis are reported. The results show that hydrolysis of amino esters 8 is very fast, much more than that of fosphenytoin.
Bosch
J
J
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain. jbosch@farmacia.far.ub.es
Roca
T
T
Domènech
J
J
Suriol
M
M
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D006868:Hydrolysis; D008297:Male; D010672:Phenytoin / Q000031:analogs & derivatives / Q000097:blood / Q000138:chemical synthesis* / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D011355:Prodrugs; D010672:Phenytoin