[Sodium efflux through lymphocytic cell membranes in patients with acute myocardial infarction].
One of the reasons of ventricular arrhythmias and coronary artery spasms in patients with acute myocardial infarction (AMI) may be the lower Na(+)-K(+)-ATPase activity, which causes decrease of potassium intracellular concentration and increase of calcium intracellular concentration. The aim of the study was the examination of the rate of sodium efflux through the lymphocytic cell membrane in patients with AMI after thrombolytic therapy. The survey was made in 50 patients with AMI after thrombolytic therapy: 30 of them with reperfusion (group I) and 20 without reperfusion (group II). The control group consisted of 31 healthy persons. Rates of total, ouabain-sensitive and furosemide-sensitive sodium efflux through the lymphocytic cell membrane were measured before thrombolysis, then 3 and 5 days after, using the method elaborated by Haegerty et al. All patients were treated with aspirin, glyceryl trinitrate and thrombolysis therapy with alteplase (r-TPA). In all patients with AMI rates of total and ouabaine-sensitive sodium efflux through the lymphocytic cell membrane were decreased, but rates of furosemide-sensitive sodium efflux were normal. In patients after thrombolytic therapy with reperfusion, 3 and 5 days after thrombolysis the decreased rates were normal, but they were still decreased in patients without reperfusion.
Katedra i Klinika Kardiologii, Akademii Medycznej, Wrocławiu.
P
P
Salomon
A
A
Mysiak
B
B
Halawa
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000628:therapy; D015425:Myocardial Reperfusion; D005996:Nitroglycerin / Q000627:therapeutic use; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D015912:Thrombolytic Therapy
D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D017506:H(+)-K(+)-Exchanging ATPase; D005996:Nitroglycerin; D001241:Aspirin
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