Use of 1-methyl-pyrrolidone as a solubilizing agent for determining the uptake of poorly soluble drugs.
Uch
A S
AS
Johann Wolfgang Goethe University, Department of Pharmaceutical Technology, Biocenter, Frankfurt/Main, Germany.
Hesse
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U
Dressman
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JB
D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics; D006854:Hydrocortisone / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D017964:Itraconazole / Q000493:pharmacokinetics; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics*; D008970:Molecular Weight; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility / Q000187:drug effects; D013997:Time Factors
D000935:Antifungal Agents; D011760:Pyrrolidinones; D017964:Itraconazole; D008353:Mannitol; C038678:N-methylpyrrolidone; D006854:Hydrocortisone