[Platelet dysfunction and pregnancy in gestational exacerbation of chronic glomerulonephritis].
OBJECTIVE
To evaluate platelet dysfunctions and pregnancy outcomes in females with gestational exacerbation of chronic glomerulonephritis (CGN) and the disease remission.


METHODS
Platelet metabolism was studied by activity of intraplatelet LDG, platelet secretory activity by plasm beta-TG and ADP-aggregation in 75 gravidae. Of them 16 had exacerbation of CGN, 40 females were in remission of CGN and 19 healthy pregnant women served control.


RESULTS
Enhanced LDG activity and intensity of maximal ADP aggregation, high beta-TG levels compared to control were recorded in gravidae with CGN both in exacerbation and remission. The frequency of preterm deliveries, intrauterine growth retardation, neonatal hypotrophy was greater in women with gestational exacerbation of nephritis compared to pregnant women with stable nephritis.


CONCLUSIONS
Metabolic and functional platelet hyperactivity with platelet intravascular activation in pregnancy in aggravated CGN suggest contribution of platelets to onset of the disease gestational exacerbation. Pregnancy-induced overactivation of platelets in CGN exacerbation stimulates intravascular coagulation in placental circulation with resultant microthrombi in placental vessels responsible for high rate of unfavorable pregnancy outcomes in relevant patients.
Kozlovskaia
N L
NL
Tareeva
I E
IE
Krylova
M Iu
MIu
Artem'eva
V B
VB
D001792:Blood Platelets / Q000502:physiology*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000150:complications; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009404:Nephrotic Syndrome / Q000097:blood / Q000209:etiology; D010974:Platelet Aggregation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D012008:Recurrence; D001620:beta-Thromboglobulin / Q000378:metabolism
D001620:beta-Thromboglobulin; D007770:L-Lactate Dehydrogenase
Disfunktsiia trombotsitov i iskhody beremennosti pri gestatsionnom obostrenii khronicheskogo glomerulonefrita.