Administration of prosaposin ameliorates spatial learning disturbance and reduces cavity formation following stab wounds in rat brain.
The effectiveness of prosaposin as a neurotrophic factor was investigated using rats with bilateral stab wounds, injecting 240 ng per day of prosaposin for 3 days. In Morris water maze task, after 3 weeks postoperation, the stab-wounds rats show significant impairment in acquisition compared with the sham-operated rats. In the transfer test the mean number of crossings of the platform place in stab-wounds was significantly lower than that in sham-operated rats (P < 0.01). The stab-wounds rats treated with prosaposin showed significant improvement (P < 0.05). The cavities following stab wounds in the rats treated with prosaposin were significantly smaller than those in the rats treated with (P < 0.05). Our data support that prosaposin is likely to be a new agent for brain injury.
Hozumi
I
I
Department of Neurology, Brain Research Institute, Niigata University, Japan. isao@bri.niigata-u.ac.jp
Hiraiwa
M
M
Inuzuka
T
T
Yoneoka
Y
Y
Akiyama
K
K
Tanaka
R
R
Kikugawa
K
K
Nakano
R
R
Tsuji
S
S
O'Brien
J S
JS
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology; D004193:Discrimination Learning / Q000187:drug effects; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D018782:Maze Learning / Q000187:drug effects; D011498:Protein Precursors / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D049231:Saposins; D013037:Spatial Behavior / Q000187:drug effects*; D014951:Wounds, Stab / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology
D006023:Glycoproteins; D011498:Protein Precursors; C483347:Psap protein, rat; D049231:Saposins