mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription.
Eukaryotic mRNA precursors are processed at their 3' ends by a coupled cleavage/polyadenylation reaction. In recent years, most of the factors involved in 3'-end processing have been identified and evidence has been presented for the coupling of mRNA 3'-end formation to capping, splicing and transcription. These links are important for the quality control of the mRNA during synthesis.
Department of Cell Biology, Biozentrum University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland. minvielle@ubaclu.unibas.ch
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Minvielle-Sebastia
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Keller
D000818:Animals; D006801:Humans; D011061:Poly A / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D012322:RNA Precursors; D012333:RNA, Messenger; D011061:Poly A