Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites.
Osteogenic proteins (OPs), also referred to as bone morphogenetic proteins (BMPs), are a family of bone-matrix polypeptides isolated from a variety of mammalian species. Implantation of osteogenic proteins induces a sequence of cellular events that leads to the formation of new bone. In preclinical studies, the implantation of recombinantly produced human osteogenic protein-1 (OP-1, also referred to as BMP-7) into surgically created, critical-size diaphyseal segmental defects resulted in the regeneration of new bone that was fully functional biologically and biomechanically. Injection of an OP-1 solution into a fresh fracture model accelerated the bone repair process compared with control fracture healing. This was the result of greater and earlier new bone formation. Further study has demonstrated that OP-1 can be used as a bone graft substitute to promote spinal fusion, aid in the incorporation of metal implants, and improve the performance of autograft and allograft bone. Clinical study of OP-1 implanted in conjunction with a bovine bone-derived type 1 collagen carrier for the treatment of tibial nonunion fractures has shown healing characteristics similar to that obtained with autogenous iliac crest bone graft. Advantages of OP-1 included no donor site complications, less blood loss, and a shorter operative time.
Department of Orthopedic Surgery, Tulane University School of Medicine, New Orleans, LA 70112-2699, USA.
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D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D002417:Cattle; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D017102:Fracture Healing / Q000187:drug effects* / Q000502:physiology; D005599:Fractures, Ununited / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D011323:Primates; D011379:Prognosis; D011817:Rabbits; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins; D013978:Tibial Fractures / Q000188:drug therapy* / Q000601:surgery
D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins