Metabotropic G-protein-coupled glutamate receptors as therapeutic targets.
Metabotropic glutamate receptors have received considerable attention over the past decade in view of their relevance in multiple aspects of glutamatergic transmission. Recent advances in the molecular biology, pharmacology and medicinal chemistry of this family of G-protein-coupled receptors have led to therapeutic opportunities for subtype-selective modulators in brain disorders and diseases such as ischemia and schizophrenia.
Pellicciari
R
R
Istituto di Chimica e Tecnologia del Farmaco, Via del Liceo 1, I-06123,Perugia, Italy. rp@unipg.it
Costantino
G
G
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D010739:Phospholipase D / Q000378:metabolism; D011487:Protein Conformation; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism
D018094:Receptors, Metabotropic Glutamate; D010739:Phospholipase D; D019204:GTP-Binding Proteins