Acute interstitial nephritis following amoxicillin overdose.
Antibiotics are commonly prescribed medications for pediatric infections. Acute interstitial nephritis has been reported with B-lactam antibiotics. We report the case of a 4-year-old boy who ingested 240 mg/kg of amoxicillin and developed acute oliguric renal failure with hematuria and crystalluria. The patient was hospitalized for serial renal function and electrolyte evaluation. Although he developed hyperkalemia, full recovery was obtained with conservative management. This case emphasizes that medications considered to be non-toxic even with overdose can have serious adverse effects which may require therapeutic intervention.
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SF
Schellie
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Groshong
D000208:Acute Disease; D000658:Amoxicillin / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D010406:Penicillins / Q000009:adverse effects*
D010406:Penicillins; D000658:Amoxicillin