Perspective article: transforming growth factor-beta: crossroad of glucocorticoid and bleomycin regulation of collagen synthesis in lung fibroblasts.
Fibrosis is a consequence of injury which is characterized by accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of normal tissue architecture and function. Transforming growth factor-beta, a potent wound healing agent, has also been shown to be an agent that can produce fibrosis because it is a potent stimulator of collagen synthesis. Both glucocorticoids and bleomycin have recently been shown to affect collagen synthesis in opposite directions, by utilizing a common pathway of involving transforming growth factor-beta activator protein binding to the transforming growth factor-beta element. This article presents a mechanistic overview of collagen synthesis regulation by glucocorticoids and bleomycin through the transforming growth factor-beta pathway.
Shukla
A
A
Department of Biochemistry, University of Vermont, Burlington 05405, USA.
Meisler
N
N
Cutroneo
K R
KR
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects*; D004195:Disease Models, Animal; D005109:Extracellular Matrix / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D055370:Lung Injury; D011485:Protein Binding; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D016212:Transforming Growth Factor beta / Q000187:drug effects / Q000502:physiology*; D014945:Wound Healing
D000903:Antibiotics, Antineoplastic; D005938:Glucocorticoids; D016212:Transforming Growth Factor beta; D001761:Bleomycin; D003094:Collagen