Potential protective effect of HSCAS and bentonite against dietary aflatoxicosis in rat: with special reference to chromosomal aberrations.
Bentonite and hydrated sodium calcium aluminsilicate (HSCAS) were added at a level of 0.5% (w/w) to the diets containing 2.5 mg aflatoxins (AF) per kg diet and fed to male mature rats for 15 successive days. Aflatoxin alone significantly decreased feed intake and altered serum biochemical parameters of liver and kidney functions. Aflatoxin caused chromosomal aberrations in bone marrow cells. Bentonite or HSCAS did not alter any of the parameters measured. The addition of bentonite or HSCAS to the AF-contaminated diet diminished most of the deleterious effects of the aflatoxin. Pathological examinations of liver and kidney proved that both bentonite and HSCAS were hepatonephroprotective agents against aflatoxicosis. The cytogenetic findings demonstrated that the addition of bentonite or HSCAS to AF-contaminated diet suppressed chromosomal aberrations. These findings indicated that bentonite and HSCAS could diminished many of the adverse effect of dietary AF in rats.
Mycotoxins Laboratory, National Research Center, Dokki, Cairo, Egypt.
M A
MA
Abdel-Wahhab
S A
SA
Nada
I M
IM
Farag
N F
NF
Abbas
H A
HA
Amra
D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000538:Aluminum Silicates / Q000494:pharmacology*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001546:Bentonite / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000648:ultrastructure; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control; D002869:Chromosome Aberrations; D004032:Diet; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D017207:Rats, Sprague-Dawley
D000348:Aflatoxins; D000538:Aluminum Silicates; D016587:Antimutagenic Agents; D001546:Bentonite; C087965:sodium calcium aluminosilicate, hydrated