Wound healing in aged normal and ovariectomized rats: effects of chemically modified doxycycline (CMT-8) on MMP expression and collagen synthesis.
Ramamurthy
N S
NS
Department of Oral Biology and Pathology, School of Dental Medicine, University Hospital and Medical Center, SUNY at Stony Brook, NY 11794-8702, USA.
McClain
S A
SA
Pirila
E
E
Maisi
P
P
Salo
T
T
Kucine
A
A
Sorsa
T
T
Vishram
F
F
Golub
L M
LM
D000375:Aging / Q000502:physiology*; D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D017364:Collagenases / Q000235:genetics; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000096:biosynthesis / Q000235:genetics*; D010052:Ovariectomy; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013754:Tetracyclines / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*; D014947:Wounds and Injuries / Q000201:enzymology / Q000503:physiopathology
D011480:Protease Inhibitors; D013754:Tetracyclines; C117153:tetracycline CMT-8; D003094:Collagen; D017364:Collagenases; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; C507083:Mmp13 protein, rat; D020784:Matrix Metalloproteinase 8; D020780:Matrix Metalloproteinase 9