Dominant lethal study of alpha-asarone in male and female mice after sub-chronic treatment.
Dominant lethal studies were conducted in male and female mice with alpha-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. alpha-Asarone did not produce germinal mutations in either males or females. Epididymal sperm examination of male mice immediately after treatment failed to reveal any alteration in sperm count on shape. No significant alterations were observed in testicular or epididymal weights or testicular histology.
Departamento de Toxicología, Escuela Nacional de Ciencias Biológicas, (I.P.N.), México D.F., México.
G
G
Chamorro
M
M
Salazar
J
J
Tamariz
F
F
Díaz
F
F
Labarrios
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009154:Mutation; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
D000081248:Allylbenzene Derivatives; D000840:Anisoles; C012195:asarone