Formula to help select rational antimicrobial therapy (FRAT): its application to community- and hospital-acquired urinary tract infections.
The selection of antimicrobial agents is guided by the use of formularies which often constrain prescribing options. There are several factors which influence the inclusion of specific agents. Two of the most important factors are microbial etiology of a disease and the incidence of antibiotic resistance. Various surveillance programs have highlighted the regional differences in antimicrobial susceptibility/resistance among various pathogens. This simple formula enables individual physicians, pharmacy and therapeutic committees and managed care formulary managers to harness local etiology and susceptibility information. In this paper the formula is applied to community- and hospital-acquired urinary tract infections.
Blondeau
J M
JM
Saskatoon & District Health and St. Paul's Hospital (Grey Nuns) and the University of Saskatchewan, Canada. blondeauj@sdh.sk.ca
Tillotson
G S
GS
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents