Nicorandil-induced severe oral ulceration: a newly recognized drug reaction.
Nicorandil, a potassium-channel activator used for the long-term treatment of ischemic heart disease, has been recently implicated as having a drug side effect of recurrent aphthous stomatitis. Three patients are reported with drug-induced aphthouslike ulceration secondary to nicorandil.
Shotts
R H
RH
Department of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University of London, United Kingdom.
Scully
C
C
Avery
C M
CM
Porter
S R
SR
D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy; D020108:Nicorandil / Q000009:adverse effects*; D019226:Oral Ulcer / Q000139:chemically induced*; D015221:Potassium Channels / Q000819:agonists*
D002317:Cardiovascular Agents; D015221:Potassium Channels; D020108:Nicorandil