Early markers of nephrotoxicity: detection of children at risk from environmental pollution.
The current investigation is the largest to date concerned with the assessment of the value of different urinary biomarkers to detect nephrotoxic effects in children exposed to cadmium and lead. A battery of tests which had proved valuable in previous studies on men and women where used, together with a number of more recently developed biomarkers. No significant effect of sex and age were found but the location of the children (site) was important. The results indicated that there might have been variability in either the assay procedures or sample handling between the different sites. A small group of tests were found to be elevated following toxic exposure and should be used in future studies. However, there was considerable variation in the degree of exposure amongst the control groups from different countries and in the test groups. This made pooling of the data difficult but the study does highlight the way forward and demonstrates that children can be at risk from environmental exposure to toxins at a lower level than is acceptable for adults.
Biochemistry Section, King's College London, United Kingdom. r.price@kcl.ac.uk
R G
RG
Price
S
S
Patel
I
I
Chivers
P
P
Milligan
S A
SA
Taylor
D000293:Adolescent; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002104:Cadmium / Q000009:adverse effects*; D002648:Child; D015331:Cohort Studies; D004781:Environmental Exposure / Q000009:adverse effects; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects*; D062665:Epidemiological Monitoring; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology* / Q000652:urine; D007854:Lead / Q000009:adverse effects*; D008297:Male; D012307:Risk Factors; D011795:Surveys and Questionnaires
D015415:Biomarkers; D004785:Environmental Pollutants; D002104:Cadmium; D007854:Lead