Increased levels of CSF soluble CD27 in patients with primary central nervous system lymphoma.
The aim of this study is to determine the diagnostic value of cerebrospinal fluid (CSF) soluble CD27 (sCD27) as a tumor marker for primary central nervous system lymphoma (PCNSL). We examined sCD27 levels in CSF obtained from various types of brain tumor patients. Forty-two patients were studied (including 12 PCNSL patients) who had not received any therapy for their tumors. In all PCNSL cases, CSF sCD27 levels were more than 15 U/ml (median 84.5 U/ml, range 17-484 U/ml) and in other brain tumor cases, CSF sCD27 levels were all less than 15 U/ml. Our data suggest that CSF sCD27 levels are useful to distinguish PCNSL from other brain tumors.
Department of Neurosurgery, Gifu University School of Medicine, Japan.
S
S
Murase
M
M
Saio
K
K
Takenaka
J
J
Shinoda
Y
Y
Nishimura
N
N
Sakai
T
T
Takami
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D016393:Lymphoma, B-Cell / Q000134:cerebrospinal fluid* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000134:cerebrospinal fluid* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000097:blood / Q000134:cerebrospinal fluid*
D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7