Sporadic carcinoid of the stomach: a highly proliferative disease with a probable role for p53 protein dysregulation.
We describe here one case of sporadic carcinoid of the stomach, occurring in a 65-year-old man. It is a rare, recently recognized entity, with only few cases reported in the literature. We were able to detect strong MIB-1 and p53 expression in this tumour, with 86 and 80% of tumoral cells positive, respectively. These data suggest that gastric sporadic carcinoids are a highly proliferative entity probably induced by dysregulation of p53 function.
Peny
M O
MO
Department of Pathology, Erasmus University Hospital, Brussels, Belgium.
Donckier
V
V
Gelin
M
M
Haot
J
J
Noel
J C
JC
D000368:Aged; D000911:Antibodies, Monoclonal; D002276:Carcinoid Tumor / Q000378:metabolism*; D002455:Cell Division; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D013274:Stomach Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53