Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Billinghurst
R C
RC
Department of Clinical Sciences, Colorado State University, Fort Collins 80523, USA. rbilli@lamar.colostate.edu
O'Brien
K
K
Poole
A R
AR
McIlwraith
C W
CW
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016895:Culture Media, Serum-Free; D006025:Glycosaminoglycans / Q000378:metabolism*; D006736:Horses; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D009924:Organ Culture Techniques; D009930:Organic Chemicals; D010654:Phenylbutyrates; D011480:Protease Inhibitors / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016895:Culture Media, Serum-Free; D006025:Glycosaminoglycans; D007375:Interleukin-1; D061965:Matrix Metalloproteinase Inhibitors; D009930:Organic Chemicals; D010654:Phenylbutyrates; D011480:Protease Inhibitors; D011994:Recombinant Proteins; C113281:Bay 12-9566; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; D020784:Matrix Metalloproteinase 8