Natural history of composite sequential bypass: ten years' experience.
BACKGROUND
We previously reported 48-month patency rates of composite sequential bypass (CSB) approaching 60%. Yet, extended patency and limb salvage rates are unknown.


OBJECTIVE
Long-term patency and limb salvage rates of CSB are affected by sex, bypass configuration, and warfarin therapy.


METHODS
Medical records of all patients who underwent CSB during a 10-year period were retrospectively reviewed.


METHODS
A referral center for the Chicago, Ill, region.


METHODS
One hundred consecutive patients (mean age, 68.8 years; 57% were men and 49% had diabetes) undergoing 102 CSBs for limb salvage (ulcer, 43%; rest pain, 39%; and gangrene, 18%) from January 1986 to January 1996 were identified.


METHODS
Warfarin was used after surgery by 72% of patients and aspirin was used by the remainder of them.


METHODS
Life table primary patency and limb salvage rates were compared for sex, diabetes mellitus status, location of distal prosthetic anastomosis (above knee vs. below knee), and anticoagulation drug therapy (warfarin sodium vs aspirin) with log-rank statistics.


RESULTS
Primary patency of CSB was 56% at 24 months, 29% at 48 months, and 20% at 84 months (SE <10%; mean follow-up, 19.6 months [range, 1.0-110.0 months]). Limb salvage rates were 64% at 24 months, 30% at 48 months, and 23% at 84 months (SE <10%); 66% and 90% of patients had failed grafts requiring amputation by 3 months and 1 year, respectively.


CONCLUSIONS
Composite sequential bypass for limb salvage provides reasonable 2-year patency. However, patency rates steadily declined from year 2 to year 5. After CSB failure, limb salvage rates are poor, with 90% of patients progressing to amputation within 1 year.
Department of Surgery, Northwestern University Medical School, Chicago, Ill, USA.
W F
WF
Oppat
W H
WH
Pearce
W D
WD
McMillan
J S
JS
Matsumura
W J
WJ
McCarthy
J S
JS
Yao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D001807:Blood Vessel Prosthesis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014654:Vascular Patency