Proteolysis by presenilins and the renaissance of tau.
Haass
C
C
Adolf-Butenandt-Institute, Dept of Biochemistry, Ludwig-Maximilians-University, Munich, Germany. Haass@as200.zi-mannheim.de
Mandelkow
E
E
D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D016874:Neurofibrillary Tangles / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D053764:Presenilin-1; D053766:Presenilin-2; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse