[The experimental chemotherapy of larval alveolar echinococcosis. The search for an optimal regimen of albendazole use].
The antiechinococcal activity of albendazole resynthesized at the E. I. Martsinovskiĭ Institute of Medical Parasitology and Tropical Medicine was studied on infection models in rats and mouse in different experimental modifications. The efficiency of the therapy was determined in relation to the dose of the drug and its routes administrations, to the single or intermittent daily dose, to the presence or absence of intervals in the treatment regimen, to dosage forms. The trials indicated that albendazole was most active against larval alveolar echinococcosis of mice or cotton rats when it was used with their feed, i.e. through the gastrointestinal tract.
Dzhabarova
V I
VI
Novik
T S
TS
D000284:Administration, Oral; D000285:Administration, Rectal; D015766:Albendazole / Q000008:administration & dosage*; D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D008081:Liposomes; D051379:Mice; D008808:Mice, Inbred CBA; D016205:Sigmodontinae; D013535:Suspensions; D013997:Time Factors
D000923:Anticestodal Agents; D004337:Drug Carriers; D008081:Liposomes; D013535:Suspensions; D015766:Albendazole
Eksperimental'naia khimioterapiia larval'nogo al'veoliarnogo ékhinokokkoza. Poisk optimal'nogo rezhima primeneniia al'bendazola.