Infectious complications of combination anticancer chemotherapy for urogenital cancers.
We reviewed the infectious complications in 207 courses of anticancer chemotherapy to 93 patients with urogenital cancer. Thirty episodes (14.5%) of neutropenic fever containing 9 cases (4.3%) of infection were observed. Five patients (16.7%) had pyelonephritis, one (3.3%) had acute prostatitis, two (6.6%) had pneumonia and one (3.3%) had bacteraemia. Multivariate analysis revealed that the infectious complications during anticancer chemotherapy were mainly associated with urinary diversion, hydronephrosis and duration of severe neutropenia (<500/mm3). These results suggest that infectious complications should be prevented in patients with urinary diversion, hydronephrosis and severe neutropenia during anticancer chemotherapy for urogenital cancer.
Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
T
T
Matsumoto
K
K
Takahashi
M
M
Tanaka
J
J
Kumazawa
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D006869:Hydronephrosis / Q000150:complications; D007239:Infections / Q000209:etiology; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009503:Neutropenia / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011704:Pyelonephritis / Q000209:etiology*; D013736:Testicular Neoplasms / Q000188:drug therapy; D014547:Urinary Diversion; D014565:Urogenital Neoplasms / Q000188:drug therapy*