Variant of the beta3-adrenergic receptor gene and coronary atherosclerosis in Japanese subjects.
In the present study, we assessed the significance of the Trp64Arg mutation in the beta3-adrenergic receptor gene in 428 Japanese subjects, including 198 subjects who underwent coronary angiography for possible ischemic heart diseases (IHD group) and 230 non-IHD subjects (control group). We conclude that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene did not appear to have any pathophysiological significance in Japanese subjects.
S
S
Tamaki
N
N
Iwai
Y
Y
Tsujita
Y
Y
Nakamura
N
N
Ohmichi
M
M
Kinoshita
D001120:Arginine / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan / Q000235:genetics
D011943:Receptors, Adrenergic, beta; D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine