P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury.
We examined brain sections from P- and E-selectin-deficient mice (-/-) and their nontransgenic littermates (+/+) after focal cerebral ischemia and reperfusion (I/R) tissue injury. There was no difference in the subsequent infarct volume after 3 h of ischemia and 21 h of reperfusion. These data indicate that selectin-independent mechanisms mediate tissue injury after a prolonged period of transient focal ischemia.
Department of Anesthesia, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. soriano@a1.tch.harvard.edu
S G
SG
Soriano
Y F
YF
Wang
D D
DD
Wagner
P S
PS
Frenette
D000818:Animals; D002544:Cerebral Infarction / Q000235:genetics / Q000473:pathology; D019040:E-Selectin / Q000235:genetics*; D005818:Genetic Engineering; D020022:Genetic Predisposition to Disease; D002546:Ischemic Attack, Transient / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009336:Necrosis; D019007:P-Selectin / Q000235:genetics*; D015427:Reperfusion Injury / Q000235:genetics* / Q000473:pathology
D019040:E-Selectin; D019007:P-Selectin