[Pulmonary aspergillosis in patients without pre-existing pulmonary disease after brain edema prevention with dexamethasone].
Pulmonary aspergillosis (PA) is a well-described complication in severely immunocompromised hosts. We report on one case of invasive PA and one case of PA following oral dexamethasone prophylaxis for cerebral oedema. Steroids were administered in a dosage of 14 mg and 16 mg, daily respectively for 21 and 15 days. Both patients died despite antifungal treatment. We conclude that PA must be considered as a cause for pulmonary complications in non-immunosuppressed, non-neutropenic patients during oral dexamethasone prophylaxis for neurological disease.
S
S
Tasci
S
S
Ewig
H
H
Schäfer
I
I
Blümcke
P
P
Leonhardt
A
A
Gillissen
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001228:Aspergillosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D001929:Brain Edema / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone
Pulmonale Aspergillose bei Patienten ohne pulmonale Vorerkrankung nach Hirnödem-Prophylaxe mit Dexamethason.