[Insertion/deletion polymorphism of the gene encoding for angiotensin-converting enzyme and microalbuminuria in essential arterial hypertension].
BACKGROUND
To assess the influence of insertion/deletion polymorphism in the ACE gene on the microalbuminuria in essential hypertension.


METHODS
Seventy-nine patients with essential hypertension (37 males and 42 females) (mean age 39 [7] years, body mass index 28 [4] kg/m2), never treated with antihypertensive drugs were included in the study. Urinary albumin excretion (UAE) was assessed in two different days. Ambulatory blood pressure (BP) was assessed during 24 h period. Genotype ACE gene and gene frequencies were determined by an assay based on the polymerase chain reaction (PCR).


RESULTS
The distribution of phenotypes was: II = 14 (17%), ID = 32 (40%) and DD = 33 (43%). The mean for UAE tended to be higher in the DD group (53.82 [88.4] mg/24 h) than ID (27.8 [39.6] mg/24 h) and II (23.8 [16.7] mg/24 h). Likewise, the average for UAE were higher in the DD group than in the II + ID group (26.6 [34.0] mg/24 h) (p = 0.06), although the differences did not achieved statistical significance. The relationship between log UAE and 24-hour mean BP was significantly higher in the DD group (r2 = 0.232; p = 0.005) than that observed in the other groups (r2 = 0.060; p = 0.101).


CONCLUSIONS
In the present study with young patients with essential hypertension, in DD genotype, UAE seems to be higher and more dependent of BP levels than in the other hypertensives.
Rovira
E
E
Unidad de Hipertensión, Hospital Clínico, Universidad de Valencia.
Chaves
F J
FJ
Julve
R
R
Pascual
J M
JM
Miralles
A
A
Armengod
M E
ME
Redon
J
J
D000328:Adult; D000419:Albuminuria / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics* / Q000652:urine; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014178:Translocation, Genetic
D007703:Peptidyl-Dipeptidase A
Polimorfismo inserción/deleción del gen codificador de la enzima conversiva de la angiotensina y microalbuminuria en la hipertensión arterial esencial.