[Pathophysiologic aspects of diabetic angiopathy].
The high incidence of vascular complications in patients with diabetes mellitus prompted us to study the pathophysiology of diabetic angiopathy. Hyperglycaemia is a common feature resulting in several metabolic and endocrine alterations and the formation of advanced glycation end-products (AGE). AGE bind to different molecules and to a receptor (RAGE). RAGE interaction with AGE enhances receptor expression and initiates a feedback loop whereby RAGE occupancy triggers increased RAGE expression. In a model of accelerated atherosclerosis associated with diabetes in genetically-manipulated mice, the blockade of cell surface RAGE by infusion in a soluble truncated form completely suppressed enhanced formation of vascular lesions. Improvement of atherosclerosis in these diabetic-atherosclerotic animals through the use of soluble RAGE occurred in the absence of changes in plasma lipids or glycaemia, which emphasises the contribution of a lipid- and glycemia-independent mechanism to atherogenesis.
Laboratoire de recherche en Biologie Vasculaire et Cellulaire, Paris.
J L
JL
Wautier
M P
MP
Wautier
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D017127:Glycation End Products, Advanced / Q000097:blood; D006031:Glycosylation; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000097:blood; D012307:Risk Factors
D001798:Blood Proteins; D017127:Glycation End Products, Advanced; D011956:Receptors, Cell Surface
Aspects physiopathologiques de l'angiopathie diabétique.