alpha-Glucosidase inhibitors from Commelina communis.
A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyranosyl alpha-homonojirimycin (5) were isolated by bioassay-directed fractionation and separation. These compounds have been identified for the first time from Commelina communis, supporting the pharmacological basis of this plant that has been used as a traditional herbal medicine for the treatment of diabetes.
H S
HS
Kim
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YH
Kim
Y S
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Hong
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NS
Paek
H S
HS
Lee
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Kim
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KW
Kim
J J
JJ
Lee
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D009754:Nuts / Q000201:enzymology; D012275:Oryza / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology; D010946:Plants, Medicinal; D012233:Rhizopus / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013552:Swine
D000470:Alkaloids; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors