Agalactosyl IgG is elevated in patients with active spondyloarthropathy.
Patients with rheumatoid arthritis or with Crohn's disease have deficient galactosylation of serum IgG [Gal(0)]. To study whether such deviation occurs in patients with spondyloarthropathy (SPA), we studied the percentage incidence of Gal(0) corrected for age [Gal(0)corr] in 47 SPA patients undergoing ileocolonoscopy and correlated the findings with clinical variables and prognosis of the patients. Gal(0)corr was elevated in 36% of the patients. Such patients had a higher number of inflamed joints (P < 0.02), higher ESR (P < 0.001) and CRP (P < 0.001). Elevated Gal(0)corr was also of prognostic significance: at 6-month follow-up those with elevated levels had a higher number of inflamed joints (P < 0.02) and ESR (P < 0.05). The presence of high Gal(0)corr did not associate with gut inflammation. In conclusion, a proportion of SPA patients has elevated levels of Gal(0), the amount of which correlates with severity of the disease and is a prognostic marker for chronicity of the disease.
Department of Medicine, Helsinki University Central Hospital, Hyks, Finland. leirisal@helsinki.fi
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Leirisalo-Repo
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Hernandez-Munoz
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Rook
D000328:Adult; D016918:Arthritis, Reactive / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D018709:Statistics, Nonparametric
D015415:Biomarkers; D007074:Immunoglobulin G; C064155:agalactosyl IGG