Activation of RNA polymerase II transcription.
Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription in vivo. Mammalian multisubunit coactivator complexes with homologs of the yeast SRB/Mediator subunits have been characterized. Structures of nuclear receptor-coactivator complexes have been determined.
Molecular Biology Institute, University of California, Los Angeles, 611 Charles E Young Drive East, BOX 951570, Los Angeles, CA 90095-1570, USA. berk@mbi.ucla.edu
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D000818:Animals; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D014157:Transcription Factors; D012319:RNA Polymerase II