alpha 2A-adrenoceptors, not I1-imidazoline receptors, mediate the hypotensive effects of rilmenidine and moxonidine in conscious mice. In vivo and in vitro studies.
Center for Biological Research, Roche Bioscience, Palo Alto, California 94304, USA. quan-ming.zhu@roche.com
Q M
QM
Zhu
J D
JD
Lesnick
J R
JR
Jasper
S J
SJ
MacLennan
M P
MP
Dillon
R M
RM
Eglen
D R
DR
Blue
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002460:Cell Line; D004285:Dogs; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007093:Imidazoles / Q000494:pharmacology*; D054755:Imidazoline Receptors; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology*; D011807:Quinolizines / Q000493:pharmacokinetics; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011955:Receptors, Drug / Q000502:physiology*; D000077769:Rilmenidine; D012501:Saphenous Vein / Q000187:drug effects / Q000502:physiology; D014162:Transfection
C547768:ADRA2A protein, human; C547769:Adra2a protein, mouse; D000959:Antihypertensive Agents; D007093:Imidazoles; D054755:Imidazoline Receptors; D010080:Oxazoles; D011807:Quinolizines; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; C054290:L 657743; D016244:Guanosine 5'-O-(3-Thiotriphosphate); C043482:moxonidine; D000077769:Rilmenidine; D009638:Norepinephrine