Biologically active anthracenones from roots of Karwinskia parvifolia.
Tullidinol, a neurotoxin isolated from fruits and roots of several Karwinskia species, was resolved for the first time into two stereoisomers. This was achieved by means of preparative HPLC from roots of Karwinskia parvifolia. Structural assignments were made on the basis of spectroscopic data, including long range correlations as well as geometry optimization by means of semi-empirical methods.
Departamento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad de Nuevo León, Mexico.
N
N
Waksman
G
G
Benavides-Cortez
V
V
Rivas-Galindo
D000818:Animals; D000873:Anthracenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001156:Artemia / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009498:Neurotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D031955:Rhamnus / Q000737:chemistry*; D013237:Stereoisomerism; D018675:Toxicity Tests
D000873:Anthracenes; D003603:Cytotoxins; D009498:Neurotoxins; D011714:Pyrans; C075148:Karwinskia toxin T-544