Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil.
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synthesized in good yield by coupling the chlorambucil moiety to positions C-2 or C-3 of the sugar, directly or via a spacer. The starting material was easily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were tested for cytotoxicity, and some of those that presented the best results were studied for inhibition of cell proliferation.
Iglesias-Guerra
F
F
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Spain.
Candela
J I
JI
Bautista
J
J
Alcudia
F
F
Vega-Pérez
J M
JM
D000328:Adult; D000606:Amino Sugars / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D002277:Carcinoma / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002699:Chlorambucil / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D003837:Deoxy Sugars / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers; D019856:Ethanolamine / Q000737:chemistry; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D009303:Nasopharyngeal Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000606:Amino Sugars; D018906:Antineoplastic Agents, Alkylating; D003837:Deoxy Sugars; D004337:Drug Carriers; D002699:Chlorambucil; D019856:Ethanolamine