The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.
The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites). Moreover, the mutant cells impose on neighboring wild-type cells more distal developmental fates, like lateral notum or wing hinge. These findings support a tergal phylogenetic origin for the most proximal part of the wing and provide evidence for a novel pattern organizing center at the border between the apposed notum (Iro-C-expressing) and hinge (Iro-C-nonexpressing) cells. This border is not a cell lineage restriction boundary.
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Antónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
R
R
Diez del Corral
P
P
Aroca
J L
JL
G mez-Skarmeta
F
F
Cavodeassi
J
J
Modolell
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000648:ultrastructure; D004625:Embryo, Nonmammalian / Q000648:ultrastructure; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018390:Gene Targeting; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D008465:Mechanoreceptors / Q000196:embryology; D009024:Morphogenesis / Q000235:genetics*; D009030:Mosaicism; D005810:Multigene Family; D013909:Thorax / Q000196:embryology; D014157:Transcription Factors; D014921:Wings, Animal / Q000196:embryology
C099257:ARA protein, Drosophila; D029721:Drosophila Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D014157:Transcription Factors; C099258:caup protein, Drosophila; C105790:mirr protein, Drosophila