Pikuroside: a novel iridoid from Picrorhiza kurroa.
A new iridoid, pikuroside (1), was isolated from the roots of Picrorhiza kurroa, together with three known iridoids, picroside I (2), picroside II (3), and 6-feruloyl catalpol (4). The structure of 1 was established by interpretation and full assignments of NMR spectral data. Pikuroside (1) had no antiinflammatory activity, although the crude extract and picroside II (3) demonstrated moderate activity.
Department of Natural Product Chemistry, Univera Pharmaceuticals, Inc., Broomfield, Colorado 80021, USA. qjia@upi1.com
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D001211:Asia, Western; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification* / Q000494:pharmacology; D003436:Croton Oil; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D007509:Irritants; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005960:Glucosides; D007509:Irritants; C120734:pikuroside; D003436:Croton Oil