Melatonin and the seasonal control of reproduction.
Many mammalian species from temperate latitudes exhibit seasonal variations in breeding activity which are controlled by the annual photoperiodic cycle. Photoperiodic information is conveyed through several neural relays from the retina to the pineal gland where the light signal is translated into a daily cycle of melatonin secretion: high at night, low in the day. The length of the nocturnal secretion of melatonin reflects the duration of the night and it regulates the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Changes in GnRH release induce corresponding changes in luteinising hormone secretion which are responsible for the alternating presence or absence of ovulation in the female, and varying sperm production in the male. It is not yet known where and how this pineal indoleamine acts to exert this effect. Although melatonin binding sites are preferentially localised in the pars tuberalis (PT) of the adenohypophysis, the hypothalamus contains the physiological target sites of melatonin for its action on reproduction. Melatonin does not seem to act directly on GnRH neurons; rather it appears to involve a complex neural circuit of interneurons that includes at least dopaminergic, serotoninergic and excitatory aminoacidergic neurons.
Laboratoire de neuroendocrinologie sexuelle, Inra, PRMD, URA CNRS 1291, France. malpaux@tours.inra.fr
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Malpaux
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Thiéry
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Chemineau
D000818:Animals; D006224:Cricetinae; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006066:Gonads / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000494:pharmacology / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D017440:Photoperiod; D010870:Pineal Gland / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D044094:Receptors, Melatonin; D012098:Reproduction / Q000187:drug effects / Q000502:physiology*; D012377:Rodentia / Q000502:physiology; D012621:Seasons; D012636:Secretory Rate; D012756:Sheep / Q000502:physiology; D013045:Species Specificity
D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D008550:Melatonin