Fibrinolytic therapy and n-acetylocysteine in the treatment of patients with acute myocardial infarction: its influence on authentic plasma hydroperoxide levels and polymorphonuclear neutrophil oxygen metabolism.
Recently it has been demonstrated that the administration of n-acetylocysteine (NAC), in combination with streptokinase, significantly diminished oxidative stress in patients with myocardial infarction. The aim of our study was to assess the influence of NAC treatment, as adjunct therapy in an evolving myocardial infarction, on the polymorphonuclear count, superoxide anion and hydrogen peroxide levels and nitric oxide production by PMNs and authentic plasma hydroperoxide (ROOH). Treatment of patients with NAC in addition to reperfusion therapy was accompanied by a significant decrease in the number of circulating polymorphonuclear neutrophils. However, the oxygen metabolism of PMNs was not affected by NAC administration. The concentration of authentic plasma hydroperoxide was significantly reduced by the administration of NAC which suggests diminished oxidative stress during acute myocardial infarction.
Division of Cardiology-Intensive Therapy, Department of Internal Medicine, University School of Medicine, Poznan, Poland.
A
A
Sajkowska
A
A
Wykretowicz
A
A
Szczepanik
M
M
Kempa
A
A
Minczykowski
H
H
Wysocki
D000111:Acetylcysteine / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D009504:Neutrophils / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy
D008054:Lipid Peroxides; D006861:Hydrogen Peroxide; D013300:Streptokinase; D000111:Acetylcysteine