The discovery and development of marine compounds with pharmaceutical potential.
An assessment of the current status of marine anticancer compounds is presented along with a case study on the aquaculture of Lissodendoryx n. sp. 1, a sponge that produces the antimitotic agents halichondrin B and isohomohalichondrin B. The use of polymer therapeutics to enhance the properties of marine natural products is considered.
Munro
M H
MH
Department of Chemistry, University of Canterbury, Christchurch, New Zealand. m.munro@chem.canterbury.ac.nz
Blunt
J W
JW
Dumdei
E J
EJ
Hickford
S J
SJ
Lill
R E
RE
Li
S
S
Battershill
C N
CN
Duckworth
A R
AR
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D017756:Aquaculture; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D018942:Macrolides; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D000095662:Polyether Polyketides
D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D018942:Macrolides; C070519:halichondrin B; D000095662:Polyether Polyketides