Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8.
The PAX8 gene, a member of the human paired box gene family, was mapped by FISH to chromosome 11 in cattle and goat and to the short arm of chromosome 3 in sheep. The cytogenetic position of PAX8 on BTA 11 and on its homologue OAR 3p lies in the region where the interleukin beta (IL1B) gene has been previously located, (BTA 11q22. 1-->q22.3 and OAR 3p25-->q26 respectively; Lòpez-Corrales et al., 1998). The results indicated that PAX8 as well as interleukin beta and interleukin alpha (IL1B and IL1A) genes detected on the human chromosome segment HSA 2q13-->q21 maintain a similar order and location in these three related species. In addition, the breakpoint in conserved synteny can now be narrowed to a position between the protein C (PROC) and PAX8 genes, which lie in close proximity on HSA 2.
Roslin Institute Edinburgh, Roslin, Midlothian UK.
N L
NL
Lòpez-Corrales
T S
TS
Sonstegard
T P
TP
Smith
D000818:Animals; D002417:Cattle / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003360:Cosmids / Q000235:genetics; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D006041:Goats / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007375:Interleukin-1 / Q000235:genetics; D009687:Nuclear Proteins; D000072636:PAX8 Transcription Factor; D051761:Paired Box Transcription Factors; D020161:Physical Chromosome Mapping; D011486:Protein C / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012756:Sheep / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
D015342:DNA Probes; D004268:DNA-Binding Proteins; D007375:Interleukin-1; D009687:Nuclear Proteins; D000072636:PAX8 Transcription Factor; C083325:PAX8 protein, human; D051761:Paired Box Transcription Factors; D011486:Protein C; D015534:Trans-Activators