[The individual and integral effects of brief simulated descents and anesthetic pharmacological preparations on human metabolism].
In short-term chamber (GVK-250) "descents" by three healthy male volunteers mechanisms of hyperbaric narcosis against high partial pressures of indifferent nitrogen and argon were compared with anesthetic ketamine and sibason. Clinical biochemistry was engaged to determine any possible changes in metabolism due to the "descents" up to 0.4-0.6 MPa. Cubital vein blood was sampled prior to and following decompression. Plasma spectrophotometry was performed using biochemical analyzer EPAC-6140 (Eppendorf, Germany) and standard sets of reagents by Raichem (USA) and Biocon (Germany). On the whole, shifts in albumin, total protein, uric acid, lactate, and the creatine kinase activity were found to be within the physiological norm. However, several cases of excursion outside the boundaries of the clinical norm (A/T, AT, lactate dehydrogenase, triglycerides, lipase) could be associated with changes in the functional state of the liver caused by administration of the anesthetics during the hyperbaric exposure.
Deviatova
N V
NV
Buravkova
L B
LB
D000222:Adaptation, Physiological; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001128:Argon / Q000494:pharmacology*; D001273:Atmosphere Exposure Chambers; D003975:Diazepam / Q000494:pharmacology*; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D008049:Lipase / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000494:pharmacology*; D010313:Partial Pressure
D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D001128:Argon; D007649:Ketamine; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase; D008049:Lipase; D009584:Nitrogen; D003975:Diazepam
Razdel'noe i sochetannoe deĭstvie kratkovremennykh imitatsionnykh pogruzheniĭ i anesteticheskikh farmakologicheskikh preparatov na metabolizm cheloveka.