Interleukin 2 (IL-2) therapy: potential advantages of locoregional versus systemic administration.
There has been an apparent discrepancy between the results obtained with IL-2 based immunotherapy in animal tumour models, including veterinary cancer patients, and human cancer patients. We argue that this is due to differences in the therapeutic regimens used to treat human and veterinary cancer patients. The main differences are systemic therapy and surgical removal of the primary tumour in case of human cancer patients, whereas these treatment modalities are not used in IL-2 treated veterinary cancer cases. We have developed a treatment protocol, in which IL-2 is applied locally, that has been successful against transplanted tumours as well as spontaneous tumours of varying origin and immunogenicity. In view of immunobiological considerations we conclude that local treatment of cancer with IL-2 makes more sense than systemic treatment, as usually applied in the clinic, and that surgical removal of tumours may be detrimental to successful IL-2 therapy.
Department of Cell Biology and Histology, University of Utrecht, P.O. Box 80.176, Utrecht, 3508 TD, The Netherlands.
M R
MR
Bernsen
J W
JW
Tang
L A
LA
Everse
J W
JW
Koten
W D
WD
Otter
D000818:Animals; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007375:Interleukin-1 / Q000627:therapeutic use*; D009369:Neoplasms / Q000601:surgery / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome
D007375:Interleukin-1