Direct enantiomeric resolution of some 2-arylpropionic acids using (-)-brucine-impregnated thin-layer chromatography.
Direct enantioseparation of (+/-)-ibuprofen and (+/-)-flurbiprofen was achieved by two-dimensional thin-layer chromatography on silica gel plates impregnated with optically pure (-)-brucine as chiral selector. The solvent systems that were successful in resolving both the compounds were acetonitrile-methanol (16:3 v/v) for the first dimension and acetonitrile-methanol-water (16:3:0.4, v/v) for the second dimension. Iodine vapour was used for detection; the detection limit for both (+/-)-ibuprofen and (+/-)-flurbiprofen was 0.1 microgram.
Department of Chemistry, University of Roorkee, India.
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R
Bhushan
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GT
Thiongo
D002855:Chromatography, Thin Layer / Q000379:methods*; D005480:Flurbiprofen / Q000737:chemistry / Q000302:isolation & purification*; D007052:Ibuprofen / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism; D013331:Strychnine / Q000031:analogs & derivatives / Q000737:chemistry
D005480:Flurbiprofen; C083806:brucine; D013331:Strychnine; D007052:Ibuprofen