[The effects of hormone replacement therapy on ovarian function in premenopausal women after hysterectomy].
OBJECTIVE
Examining the consequences of temporary postoperative hormone replacement therapy following hysterectomy for the function of the ovaries and the subjective well-being of women.


METHODS
Hormone profiles (Estradiol, FSH, LH, Testosterone, DHEA) and typical estradiol deficiency phenomena were investigated prospectively in premenopausal hysterectomized women with intact ovaries. Group 1 (n = 21) was replaced transdermally following surgery for 3 weeks with estradiol patch 0.05 mg daily. Group 2 (n = 21) got no hormones.


RESULTS
Group 1 had a remarkable decrease of estradiol after 10 days to 59% and after 6 weeks to 71% of the starting point. Gonadotropins showed an increase in this group. In group 2 without replacement there was only a small decrease of estradiol after 10 days and after 6 weeks the level was higher than before hysterectomy. Testosterone also decreased in group 1 to 64% of the level before surgery after 6 weeks, whereas in the comparing group it was 87%. On the other hand in group 1 only 2 of 21 women, but 10 of 21 in group 2 showed climacteric-like symptoms.


CONCLUSIONS
HRT over 3 weeks induces ovarian suppression, which is still seen 6 weeks after hysterectomy. But hormonally treated women have clearly less subjective complaints.
Abt. Endokrinologie, Universitäts-Frauenklinik Heidelberg.
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Kuckatz
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Eicher
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Klinga
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Mueck
D000328:Adult; D003687:Dehydroepiandrosterone / Q000097:blood; D004414:Dyspareunia / Q000209:etiology / Q000517:prevention & control; D004958:Estradiol / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D019584:Hot Flashes / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology*; D017060:Patient Satisfaction; D011182:Postoperative Care; D017697:Premenopause; D011446:Prospective Studies; D012893:Sleep Wake Disorders / Q000209:etiology / Q000517:prevention & control; D018709:Statistics, Nonparametric; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Auswirkungen einer hormonellen Substitutionstherapie bei hysterektomierten prämenopausalen Frauen auf die ovarielle Funktion.