Nonsteroidal anti-inflammatory activity of 1,2,4-triazolyl-heterocarboxylic derivatives.
A series of 1,2,4-triazolyl-thiophene and 1,2,4-triazolyl-pyrazole carboxylic acid derivatives was tested for acute toxicity and nonsteroidal anti-inflammatory activity. Some of these compounds showed potent analgesic activity and interesting nonsteroidal anti-inflammatory properties in different acute and chronic inflammation models.
Departamento de Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
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Darias
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Abdala
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ML
Tello
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Martín Herrera
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Vega
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000473:pathology; D001760:Bleeding Time; D002264:Carboxylic Acids / Q000494:pharmacology* / Q000633:toxicity; D002351:Carrageenan; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D003368:Gossypium; D006099:Granuloma / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced; D014230:Triazoles / Q000494:pharmacology* / Q000633:toxicity
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D014230:Triazoles; D002351:Carrageenan