Multiple cerebral infarctions associated with ovarian hyperstimulation syndrome.
A 26-year-old woman on human menopausal gonadotrophin-human chorionic gonadotrophin therapy for sterility showed multiple cerebral infarctions associated with ovarian hyperstimulation syndrome. A hypercoagulable state (hemoconcentration, increased plasma levels of D-dimer and thrombin-antithrombin III complex, and decreased protein S activity) was associated with her thromboembolic events. Cerebral infarction associated with mild neurologic deficits may be overlooked in patients with ovarian hyperstimulation syndrome.
Department of Neurology, Tokai University School of Medicine, Isehara, Japan. yoshii@is.icc.u-tokai.ac.jp
F
F
Yoshii
N
N
Ooki
Y
Y
Shinohara
K
K
Uehara
F
F
Mochimaru
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008596:Menotropins / Q000009:adverse effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D010062:Ovulation Induction / Q000009:adverse effects*; D010447:Peptide Hydrolases / Q000032:analysis; D017293:Protein S / Q000032:analysis; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D017293:Protein S; C046193:antithrombin III-protease complex; D008596:Menotropins; D000990:Antithrombin III; D010447:Peptide Hydrolases