Vasospastic angina likely related to cisplatin-containing chemotherapy and thoracic irradiation for lung cancer.
Vasospastic angina is rarely observed during cancer treatment. The present report describes two males with lung cancer, aged 73 and 61, who developed vasospastic angina during combination treatment of cisplatin-containing chemotherapy and thoracic irradiation. As both patients have smoked and their ages are typical for patients with coronary artery disease, such events may be incidental. However, oncologists should be aware of the possible development of myocardial ischemia during or following administration of antineoplastic agents, especially in elderly patients with pre-existing coronary risk factors or a history of thoracic radiotherapy.
Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital.
M
M
Fukuda
M
M
Oka
N
N
Itoh
T
T
Sakamoto
H
H
Mori
A
A
Hayakawa
S
S
Kohno
D000230:Adenocarcinoma / Q000628:therapy*; D000368:Aged; D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000503:physiopathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D018288:Carcinoma, Small Cell / Q000628:therapy*; D002945:Cisplatin / Q000009:adverse effects; D004562:Electrocardiography; D005047:Etoposide / Q000009:adverse effects; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology / Q000528:radiation effects*; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000209:etiology* / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects*; D014751:Vindesine / Q000009:adverse effects
D005047:Etoposide; D002945:Cisplatin; D014751:Vindesine