Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that, despite the presence of numerous donor antigen-presenting cells, only host-derived antigen-presenting cells initiated graft versus host disease. Thus, strategies for preventing graft versus host disease could be developed that are based on inactivating host antigen-presenting cells. Such strategies could expand the safety and application of allogeneic bone marrow transplantation in treatment of common genetic and neoplastic diseases.
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
W D
WD
Shlomchik
M S
MS
Couzens
C B
CB
Tang
J
J
McNiff
M E
ME
Robert
J
J
Liu
M J
MJ
Shlomchik
S G
SG
Emerson
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control*; D006183:H-2 Antigens / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D015778:Minor Histocompatibility Antigens / Q000276:immunology; D013154:Spleen / Q000276:immunology; D018183:Transplantation Chimera
D006183:H-2 Antigens; D015778:Minor Histocompatibility Antigens