Excess catecholamine syndrome. Pathophysiology and therapy.
In addition to genetic factors, lifestyle has a predominant influence on primary hypertension and noninsulin-dependent diabetic mellitus (NIDDM). We initiated studies using radiotelemetry for characterizing molecular events linked with excess calorie intake and psychologic stress. An increased calorie intake was associated with raised (p < 0.05) systolic and diastolic blood pressure as well as heart rate independent of day-night cycle. Sympathetic activity was in excess when related to the unchanged motility. The hyperkinetic hypertension is expected to result in adverse remodeling of resistance vessels and to aggravate insulin resistance. To examine adverse effects of psychological stress, rats were subjected to intermittent food pellet feeding. Urinary catecholamines and cardiac norepinephrine stores were increased (p < 0.05). The depressed (p < 0.05) rate of Ca2+ uptake of sarcoplasmic reticulum is expected to contribute to cellular Ca2+ overload. These lifestyle influences strengthen the notion of an excess catecholamine syndrome which requires selective reduction of sympathetic outflow of the brain by I1-receptor agonists.
Molecular Cardiology Laboratory, Philipps University of Marburg, Germany.
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D000428:Alcohol Drinking / Q000503:physiopathology; D000818:Animals; D002395:Catecholamines / Q000097:blood / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D002149:Energy Intake; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008019:Life Style; D008954:Models, Biological; D051381:Rats; D013315:Stress, Psychological / Q000503:physiopathology*; D013577:Syndrome
D002395:Catecholamines