Osteoarthritis caused by Neocosmospora vasinfecta.
We report the case of a patient who developed an ankle osteoarthritis due to the Ascomycete Neocosmospora vasinfecta, following accidental multiple trauma to his legs in whilst in Africa. Antifungal susceptibility testing was performed. Despite a low amphotericin B minimal inhibitory concentration, parenteral antifungal therapy failed and amputation was required to resolve the osteoarthritis. Possible reasons for the failure of this antifungal treatment are examined.
Laboratoire de Parasitologie-Mycologie, Hôpital Tenon, Paris, France.
G
G
Kac
P
P
Piriou
E
E
Guého
P
P
Roux
J
J
Trémoulet
M
M
Denis
T
T
Judet
D000328:Adult; D006801:Humans; D006999:Hypocreales / Q000145:classification* / Q000302:isolation & purification; D008297:Male; D009181:Mycoses / Q000382:microbiology* / Q000601:surgery; D010003:Osteoarthritis / Q000382:microbiology* / Q000601:surgery