Cell cycle events during renal injury.
Recovery from ischemic and nephrotoxic acute renal failure requires replacement of damaged tubule cells in order to restore the morphological and functional integrity of the renal epithelium. A more thorough understanding of the renal stress response and its molecular interactions with the cell cycle machinery will be important areas of biomarker research in nephrotoxicity. Many of these molecular targets should be detectable hopefully without resorting the invasive techniques.
Division of Nephrology, University of Texas Medical Branch, Galveston 77555-0562, USA. rsafirst@utmb.edu
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Safirstein
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D015415:Biomarkers; D002453:Cell Cycle; D006801:Humans; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply* / Q000166:cytology* / Q000473:pathology; D013312:Stress, Physiological / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers