[Prospective comparative study of HCV serologic status in and AIDS population].
OBJECTIVE
Study the influence of hepatitis C virus (HCV) serology on the course of HIV disease in AIDS patients.


METHODS
A prospective study of survival prognosis in HIV infected patients who had reached the AIDS stage was conducted in the Saint-Etienne, Clermond-Ferrand and Lyons infectious disease centers to compare patients with positive and negative HCV serology. Data were collected using the clinico-epidemiological software DMI II. The effect of HCV ìco-infectionî defined by RIBA II or III confirmed seropositivity, was studied using Kaplan-Meier survival plots.


RESULTS
Among the 1,005 HIV-infected subjects included in the study, 219 had AIDS and 43 of them (19.6%) were HCV positive. Survival curves in HIV/HCV positive patients with AIDS were not significantly different from those of HCV-negative AIDS patients (median 17.8 versus 18.6 months respectively, p = 0.93). This result was confirmed by univariate Kaplan-Meier analysis. Only 2 patients were treated with interferon and no deaths were attributed to liver disease.


CONCLUSIONS
HCV positivity in AIDS patients does not appear to influence survival. The longer survival obtained with the new anti-retroviral treatments may have an effect on the HIV-HCV interaction.
Service des maladies infectieuses, CHU Archet 1, Nice.
S
S
Chaillou
P
P
Berthelot
C
C
Guglielminotti
B
B
Pozzetto
A
A
Frésard
H
H
Pegue-Lafeuille
J
J
Beytout
D
D
Peyramond
F
F
Lucht
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D000998:Antiviral Agents / Q000627:therapeutic use; D016174:Hepacivirus / Q000302:isolation & purification; D006526:Hepatitis C / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D006801:Humans; D008297:Male; D008403:Mass Screening; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate
D000998:Antiviral Agents
Etude pronostique comparative d'une population SIDA en fonction du statut sérologique VHC.