Calcium phosphate formation on porous sol-gel-derived SiO2 and CaO-P2O5-SiO2 substrates in vitro.
Sol-gel-derived SiO2 and CaO-P2O5-SiO2 have been shown to be bioactive and bone bonding. In this study bioactive sol-gel-derived SiO2 and CaO-P2O5-SiO2 systems were tested for in in vitro bioactivity. The calcined ceramic monoliths were immersed in a simulated body fluid and analyzed to follow the hydroxyapatite formation on the ceramic surface. Apatite-forming ability was investigated in terms of structural changes by changing the composition and the preparation method. The role of Ca and P dopants in the substrate structure is complicated, and careful characterization is needed. The composition and structure together determine the in vitro bioactivity. The pore structure was analyzed using N2-adsorption/desorption isotherms. The results indicate that a great mesopore volume and a wide mesopore size distribution favor hydroxycarbonate apatite nucleation and a great surface area is not needed. The performed preparation process for silica in a basic environment provides a convenient way to prepare a mesoporous material.
Peltola
T
T
Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, FIN-20520 Turku, Finland.
Jokinen
M
M
Rahiala
H
H
Levänen
E
E
Rosenholm
J B
JB
Kangasniemi
I
I
Yli-Urpo
A
A
D000327:Adsorption; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003764:Dental Materials / Q000737:chemistry*; D005782:Gels; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry*; D017553:Phosphorus Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D013499:Surface Properties
D017610:Calcium Compounds; D002130:Calcium Phosphates; D003764:Dental Materials; D005782:Gels; D010087:Oxides; D017553:Phosphorus Compounds; C012500:phosphorus pentoxide; D012822:Silicon Dioxide; C016538:lime