Incidence and outcome of a 10-fold indomethacin overdose in premature infants.
We reviewed the incidence and morbidity of a 10-fold medication error among all premature infants treated with indomethacin. We detected 4 incidents among 1059 indomethacin doses given to infants weighing less than 1000 g. None of the infants had intracranial hemorrhage, necrotizing enterocolitis, or significant deterioration of renal function.
Cardiovascular Research Institute and Department of Pediatrics, University of California, San Francisco, 94143-0544, USA.
M
M
Narayanan
M
M
Schlueter
R I
RI
Clyman
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000506:poisoning*; D001997:Bronchopulmonary Dysplasia / Q000139:chemically induced; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D020345:Enterocolitis, Necrotizing / Q000139:chemically induced; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000506:poisoning*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data*; D012189:Retrospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin