Clorgyline and deprenyl attenuate striatal malonate and 3-nitropropionic acid lesions.
We have previously shown that dopamine depletion reduces striatal damage elicited by the mitochondrial neurotoxins malonate and 3-nitropropionic acid (3NP). Metabolism of dopamine by monoamine oxidase results in the formation of hydrogen peroxide, which may mediate dopamine toxicity. In this study, administration of the monoamine oxidase inhibitors clorgyline and deprenyl resulted in a 42% and 75% reduction in lesion volumes in malonate- and 3NP-treated animals, respectively, compared to controls.
Department of Neurology, University of Kentucky Medical Center, Lexington, KY, USA.
W F
WF
Maragos
P A
PA
Tillman
M D
MD
Chesnut
R J
RJ
Jakel
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000473:pathology*; D042963:Electron Transport Complex II; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D009498:Neurotoxins / Q000494:pharmacology; D009574:Nitro Compounds; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012642:Selegiline / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D008314:Malonates; D008996:Monoamine Oxidase Inhibitors; D009097:Multienzyme Complexes; D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; D012642:Selegiline; C030290:malonic acid; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D003010:Clorgyline; C015392:3-nitropropionic acid