Synthesis of 6- and 7-hydroxyestradiol 17-sulfates: the potential metabolites of estradiol 17-sulfate by female rat liver microsomes.
The potential ring-B hydroxylated metabolites of estradiol 17-sulfate (1) by female rat liver microsomes were chemically prepared as authentic compounds. They are 6alpha- and 6beta-hydroxyestradiol 17-sulfates (7 and 9), and 7alpha- and 7beta-hydroxyestradiol 17-sulfates (12 and 16), whose synthetic procedures are described.
Itoh
Y
Y
Hokkaido College of Pharmacy, Otaru, Japan.
Matsuda
N
N
Harada
K
K
Takanashi
K
K
Watanabe
K
K
Takagi
H
H
Itoh
S
S
Yoshizawa
I
I
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D005260:Female; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
C121074:6-hydroxyestradiol 17-sulfate; C121075:7-hydroxyestradiol 17-sulfate; C048615:estradiol 17-sulfate; D004958:Estradiol