Attenuation of dopamine uptake in vivo following priming with estradiol benzoate.
Dopamine (DA) uptake and clearance were examined using in vivo voltammetry following injection of DA (200 microM) into the nucleus accumbens of ovariectomized (OVX) or OVX-estrogen-primed rats (estradiol benzoate, EB, 10 microg 48 and 24 h prior to experiment). The rate of DA uptake was significantly attenuated in steroid-treated animals: this decrease was accompanied by a significant increase in DA clearance time. Quinpirole (0.5 mg/kg) modulated the kinetics of DA uptake in OVX but not EB-primed rats. These data suggest that DA clearance can be regulated by physiological doses of EB.
Division of Basic Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA 31207, USA. thompson.t@gain.mercer.edu
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D000818:Animals; D004298:Dopamine / Q000493:pharmacokinetics*; D018491:Dopamine Agonists / Q000494:pharmacology; D004594:Electrophysiology / Q000379:methods; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D010052:Ovariectomy; D019257:Quinpirole / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D018491:Dopamine Agonists; D019257:Quinpirole; D004958:Estradiol; D004298:Dopamine