Association study of schizophrenia among Indian families.
A putative association of schizophrenia with a Msc I restriction fragment length polymorphism at the dopamine D3 receptor gene locus (DRD3) was tested among Indian families, using haplotype relative risk analysis and the transmission disequilibrium test (n=66 families and 58 sets of transmissions, respectively). A significant association either with homozygosity or with allele 1 at the biallelic polymporphism could not be detected.
Department of Genetics, Delhi University, New Delhi, India.
S
S
Prasad
S N
SN
Deshpande
T
T
Bhatia
J
J
Wood
V L
VL
Nimgaonkar
B K
BK
Thelma
D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007194:India; D015810:Linkage Disequilibrium; D008297:Male; D015233:Models, Statistical; D012150:Polymorphism, Restriction Fragment Length; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3