[LSD and cannabis abuse in early pregnancy with good perinatal outcome. Case report and review of the literature].
This is a case report of a 27-year-old patient who had smoked a joint (cannabis) and 20 cigarettes (tobacco) daily up to the time of a positive pregnancy test at 7 4/7 weeks (p.c.). On day 20 p.c. she had an LSD minitrip. There are reports of chromosome aberrations in in vitro animal studies with LSD. In humans the main consequences are malformations of the fetal extremities and dysplasias of the eye. In both animals and humans cannabis causes changes in dopaminergic activity. Our recommendation was to continue the pregnancy, but to monitor it closely. The patient had a spontaneous term delivery-a lively boy with weight between the 5th and the 50th percentile, length between the 50th and the 90th percentile, normal umbilical arterial and venous pH values, and Apgar scores 7/9/10. There were no visible abnormalities, and behaviour was normal. If it is suspected that a pregnant patient consumes LSD, dysplasias of the fetal skeleton and eye should be checked for. With respect to LSD and to cannabis, too, the intellectual development of the child should be closely followed.
Departement Frauenheilkunde, Klinik und Poliklinik für Geburtshilfe, Universitätsspital Zürich, Schweiz. uvm@fhk.usz.ch
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von Mandach
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Rabner
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J
Wisser
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Huch
D000328:Adult; D001034:Apgar Score; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects; D008297:Male; D002189:Marijuana Abuse; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013997:Time Factors
D008238:Lysergic Acid Diethylamide
LSD- und Cannabis-Konsum während der frühen Schwangerschaft mit gutem perinatalen Ausgang. Fallbericht und Literaturübersicht.