Mathemycin B, a new antifungal macrolactone from actinomycete species HIL Y-8620959.
A new macrocyclic lactone antibiotic mathemycin B (1) was isolated from the fermentation broth of an Actinomycete sp. culture Y-8620959. The structure of 1 was elucidated by high-resolution MS and interpretation of 2D NMR results. Mathemycin B is active against a variety of phytopathogenic organisms.
Research Centre, Hoechst Marion Roussel Ltd., Mulund (W), Mumbai 400 080, India. TMukho@HOECHSTRES.RPGMS.ems.vsnl.net.in
T
T
Mukhopadhyay
S R
SR
Nadkarni
R G
RG
Bhat
S V
SV
Gupte
B N
BN
Ganguli
S
S
Petry
H
H
Kogler
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C120731:mathemycin B