Real-time fMRI paradigm control, physiology, and behavior combined with near real-time statistical analysis.
This study presents an integrated approach to on-line fMRI data processing that combines real-time paradigm control and real-time MR image statistical analysis with nearly real-time integration of fMRI behavioral and physiological data. The real-time paradigms involve accurate timing control of multiple independent processing streams for stimulus presentation, physiological monitoring, behavioral response recording, and scanner synchronization. The real-time image analysis provides high resolution MR image reconstruction, head motion detection, translational motion correction, and t test statistical activation maps for either block design or single-trial based paradigms. The near real-time analysis allows physiological and behavioral data collected during a paradigm to be combined with the MR time series and provides extended data filtering and statistical processing within a few minutes after the end of the scan. This integrated approach improves fMRI reliability for both clinical and research studies.
Voyvodic
J T
JT
Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001288:Attention / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology; D001931:Brain Mapping / Q000295:instrumentation*; D002540:Cerebral Cortex / Q000502:physiology; D003199:Computer Systems; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008838:Microcomputers; D011597:Psychomotor Performance / Q000502:physiology; D012016:Reference Values; D012984:Software; D014796:Visual Perception / Q000502:physiology