Transient MRI enhancement in a patient with seizures and previously resected glioma: use of MRS.
A 35-year-old man presented with partial seizures 10 years after resection of a left-sided glioblastoma multiforme. At the old operative site MRI demonstrated extensive cortical and white matter gadolinium enhancement, and PET showed hypermetabolism. Biopsy of the area was postponed when MRS showed a normal biochemical spectrum. MRI and PET abnormalities resolved after control of the seizures. MRS is noninvasive and can provide essential information in the management of patients with seizures and previously treated cerebral neoplasms.
Quan
D
D
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19103, USA.
Hackney
D B
DB
Pruitt
A A
AA
Lenkinski
R E
RE
Cecil
K M
KM
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D002330:Carmustine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014055:Tomography, Emission-Computed
D000927:Anticonvulsants; D018906:Antineoplastic Agents, Alkylating; D010672:Phenytoin; D002330:Carmustine