[Comparative study of three systems for in vitro activity investigation of fluconazole against yeast isolates of clinical interest].
BACKGROUND
Study of antifungal sensitivity can help in treatment screening and evaluation of patients suffering from some fungal infections. The purpose of this study is to compare fluconazole MICs obtained by E-test and agar dilution with the NCCLS method.


METHODS
The in vitro activity of fluconazole against 158 yeast strains by three systems: E-test, agar dilution and the microbroth NCCLS M27P method.


CONCLUSIONS
A correlation between 84 to 100% was observed the degree varying in the result among different species. The E-test was found to be comparable to the NCCLS M27P microbroth method, was easier to perform and provides MIC result for Candida species within 24 h.
Linares
M J
MJ
Servicio de Microbiología, Hospital Universitario Reina Sofía, Facultad de Medicina, Universidad de Córdoba.
Solís
F
F
Muñoz
J F
JF
Rodríguez
F C
FC
Valero
A
A
Casal
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D015725:Fluconazole
Estudio comparativo de tres sistemas para la investigación in vitro de la actividad del fluconazol frente a organismos levaduriformes de interés clínico.