["Buffalo neck": an unintended secondary effect of treatment with anti-HIV protease inhibitors].
BACKGROUND
Lipodystrophy and other fat distribution disorders have been reported in patients receiving protease inhibitor therapy for HIV infection.


METHODS
A 50-year-old HIV-positive patient was given protease inhibitor therapy (indinavir) for 6 months when he developed a lipomatous formation in the retrocervical area. Abdominal fat also increased in volume and the subcutaneous fat on the lower limbs decreased.


CONCLUSIONS
We describe the main clinical features of these fat distribution disorders and discuss the pathogenic hypothesis of an interaction between antiprotease activity and hepatic lipoprotein receptor binding.
Milpied-Homsi
B
B
Clinique Dermatologique, Hôtel-Dieu, Nantes.
Krempf
M
M
Gueglio
B
B
Raffi
F
F
Stalder
J F
JF
D000005:Abdomen / Q000473:pathology; D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology*; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003240:Connective Tissue Diseases / Q000139:chemically induced*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006679:HIV Seropositivity / Q000188:drug therapy; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D007866:Leg / Q000473:pathology; D008060:Lipodystrophy / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology*
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D019469:Indinavir
"Bosse de bison": un effet secondaire inattendu des traitements par inhibiteurs de protéases anti-VIH.