The relationship between levels of neutrophil-related factors and the degree of surgical stress.
To find a method for estimating the degree of surgical stress, 53 patients were divided into 3 groups according to operation time (group I, > or =5 h or more; group II, 1-4 h; and group III, <1 h) and measurement of neutrophil-related factors was performed. The postoperative levels of chemiluminescence (CL) generated by neutrophils (5.5 x 10(8)cpm) in group I was significantly higher than that in group II (2.1 x 10(8)cpm). The postoperative levels of CL in whole blood (5.7, 2.9, 1.0 x 10(6)cpm for groups I, II and III, respectively) and plasma lactoferrin levels (Lf) (653, 302, 143 ng/ml) were highest in group I and lowest in group III. The serum iron (Fe) level (24, 32, 58 microg/dl for groups I, II, III) was highest in group III and lowest in group I. In conclusion, whole blood CL, neutrophil CL, Lf and Fe levels after surgery can be useful indicators of the degree of surgical stress.
First Department of Surgery, Okayama University Medical School, Japan. isozakih@med.okayama-u.ac.jp
H
H
Isozaki
H
H
Nishino
S
S
Sako
Y
Y
Naomoto
N
N
Tanaka
D000368:Aged; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D007781:Lactoferrin / Q000097:blood; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D018375:Neutrophil Activation; D013312:Stress, Physiological / Q000503:physiopathology*; D013514:Surgical Procedures, Operative
D007501:Iron; D007781:Lactoferrin