Infectious complications of combination anticancer chemotherapy for urogenital cancers.
We reviewed the infectious complications in 207 courses of anticancer chemotherapy to 93 patients with urogenital cancer. Thirty episodes (14.5%) of neutropenic fever containing 9 cases (4.3%) of infection were observed. Five patients (16.7%) had pyelonephritis, one (3.3%) had acute prostatitis, two (6.6%) had pneumonia and one (3.3%) had bacteraemia. Multivariate analysis revealed that the infectious complications during anticancer chemotherapy were mainly associated with urinary diversion, hydronephrosis and duration of severe neutropenia (<500/mm3). These results suggest that infectious complications should be prevented in patients with urinary diversion, hydronephrosis and severe neutropenia during anticancer chemotherapy for urogenital cancer.
Matsumoto
T
T
Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Takahashi
K
K
Tanaka
M
M
Kumazawa
J
J
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D005260:Female; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D006869:Hydronephrosis / Q000150:complications; D007239:Infections / Q000209:etiology; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009503:Neutropenia / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000188:drug therapy; D011704:Pyelonephritis / Q000209:etiology*; D013736:Testicular Neoplasms / Q000188:drug therapy; D014547:Urinary Diversion; D014565:Urogenital Neoplasms / Q000188:drug therapy*