Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.
BACKGROUND
Hyperactivity and hypoactivity of the HPA have been forwarded as of pathophysiological relevance in major depressive disorder and chronic fatigue syndrome (CFS), respectively.


METHODS
This study examines cortisol levels in the two disorders, and also assesses levels of the adrenal androgens, dehydroepiandrosterone (DHEA) and its sulphate derivative (DHEA-S), and 17-alpha-hydroxyprogesterone; 15 subjects with CFS diagnosed according to CDC criteria, 15 subjects with DSM III-R major depression and 11 healthy subjects were compared.


RESULTS
DHEA and DHEA-S levels were significantly lower in the CFS compared to the healthy group; DHEA-S levels, but not DHEA, were lower in the depressives; cortisol and 17-alpha-hydroxyprogesterone did not differ between the three groups.


CONCLUSIONS
A potential role for DHEA, both therapeutically and as a diagnostic tool, in CFS, is suggested.
Department of Psychiatry, Trinity College Medical School, Dublin, Ireland.
L V
LV
Scott
F
F
Salahuddin
J
J
Cooney
F
F
Svec
T G
TG
Dinan
D000328:Adult; D003687:Dehydroepiandrosterone / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood*; D015673:Fatigue Syndrome, Chronic / Q000097:blood*; D005260:Female; D006304:Health Status; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D012720:Severity of Illness Index
D003687:Dehydroepiandrosterone; D006854:Hydrocortisone