Post-mortem incidental finding of cytomegalovirus oophoritis after an allogeneic stem cell transplant.
Cytomegalovirus (CMV) disease is a common and serious complication of allogeneic stem cell transplantation (SCT). Its two most frequent manifestations are interstitial pneumonitis and gastroenteritis. We describe here the first reported case of CMV ovarian infection in an allo-SCT recipient. This patient was included in a clinical trial of high-dose chemotherapy (HDCT) with HLA-matched peripheral SCT for metastatic breast cancer. She expired 53 days after transplantation from organ failure unrelated to her CMV oophoritis.
University of Colorado Bone Marrow Transplant Program, Denver 80262, USA.
Y
Y
Nieto
M
M
Ross
R
R
Gianani
E J
EJ
Shpall
P J
PJ
Cagnoni
S I
SI
Bearman
R B
RB
Jones
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy; D003131:Combined Modality Therapy; D003586:Cytomegalovirus Infections / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009869:Oophoritis / Q000209:etiology* / Q000821:virology*