[Immunological behavior (IgG, IgM, IgA) and total complement (CH50) of newborns infants with risk factors for early onset sepsis. Comparative analysis of newborns with and without infection].
Immunological behavior (IgG, IgM, IgA) and total Complement (CH50) of newborns infants with risk factors for early onset sepsis. Comparative analysis between newborns with and without infection. Rev. Hosp. Clín. Fac. Med. S. Paulo, 53(6): 303-310, 1998. The objective of this study was to verify the immunological behavior of the newborn infant in front of an infection. We studied 60 newborn infants that had risk factors for early onset sepsis (premature rupture membranes, clinic amnionitis or tract urinary infection) from de immunological and infection point of view. They were classified into three gestational age groups: < 34 weeks, between 34 and 36 6/7 weeks and > or = 37 weeks. Sepsis diagnosis was done through clinical and laboratorial data and we also included the followings exams: Immunological types (IgG, IgM, IgA) and total complement (CH50) obtained from the newborn at birth and on the fifth day of life. We could verify that 15 newborns (25%) presented early sepsis. There was a statistical association between perinatal asfixia and infection in the group with gestational age < 34 weeks and this same group presented statistical association between infection and death. The serical levels of IgG and CH50 were directly related to the gestational age and there were significant statistical differences between levels of IgG, IgM and total Complement between infected and not infected newborns within the same group os gestional age. We observed that the infection was associated to low levels of IgG and CH50, at birth and on the fifth day, mainly in the group of infected newborns with gestional age < 34 weeks, being this group, therefore, the one that would mostly benefit from an immunological support in front of and infection.
Unidade de Cuidados Intensivos Neonatais (UCINE), Instituto da Criança Prof. Pedro de Alcántara, Hospital das Clínicas da FMUSP e na Casa de Saúde Santa Marcelina.
M E
ME
Ceccon
E M
EM
Diníz
M M
MM
Carneiro-Sampaio
C
C
Arslanian
C L
CL
Diogo
J L
JL
Ramos
F A
FA
Vaz
D015941:Complement Hemolytic Activity Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D018805:Sepsis / Q000175:diagnosis*; D013997:Time Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins
Comportamento imunológico (IgG, IgM, IgA) e complemento total (CH 50) de recém-nascidos com fatores de risco para sepse precoce. Análise comparativa entre recém-nascidos com e sem infecção.