Physico-chemical characterization of meglumine antimoniate.
The leishmanicidal drug, meglumine antimoniate (MA), has been synthesized by the reaction of antimony oxyhydrated and N-methyl glucamine. Infrared and solid state NMR 13C analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon. Potentiometric titration indicated that, between pH 4.5 and 7.5, MA exists in the zwitterionic form.
Demicheli
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Departamento de Química, Universidade Federal de Minas Gerais, Brasil.
de Figueiredo
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Carvalho
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Sinesterra
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Lopes
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Frézard
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D000981:Antiprotozoal Agents / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007896:Leishmaniasis / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D008536:Meglumine / Q000737:chemistry*; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000737:chemistry*; D011199:Potentiometry
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate