Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature.
OBJECTIVE
To report 4 cases of hybrid carcinoma and to review the literature on these rare neoplasms of the salivary gland.


METHODS
Hematoxylin-eosin-stained, formalin-fixed, paraffin-embedded tissue sections from 3 parotid tumors and 1 palate tumor were examined.


RESULTS
The cases were classified as adenoid cystic and mucoepidermoid carcinoma, adenoid cystic and epithelial-myoepithelial carcinoma, epithelial-myoepithelial and salivary duct carcinoma, and adenoid cystic and salivary duct carcinoma. All patients were men, 28 to 71 years old; 3 patients presented with parotid mass, and 1 patient presented with palatal mass. One patient presented with facial nerve paralysis and pain. The soft palatal tumor was a slowly growing mass with maxillary sinus involvement at the time of the diagnosis. All patients were treated with surgery and radiotherapy.


CONCLUSIONS
Correct identification of 2 or more neoplastic entities will help assess the aggressiveness and metastatic potential of the tumor and influence the clinical course and treatment.
Croitoru
C M
CM
Department of Pathology, University of Texas Medical School, Houston 77030, USA.
Suarez
P A
PA
Luna
M A
MA
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000473:pathology; D018277:Carcinoma, Mucoepidermoid / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000473:pathology*; D010159:Palate; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed