Some aspects of oligoribonucleotides synthesis via the H-phosphonate approach.
This review gives a short account of selected aspects of oligoribonucleotide synthesis via the H-phosphonate method. It includes: (i) recent methods for the preparation of suitably protected ribonucleoside 3'-H-phosphonates (the phosphonylation step), (ii) some chemical and stereochemical features of the formation of H-phosphonate internucleosidic linkages, and (iii) stereoselective synthesis of oligoribonucleoside phosphorothioates using chemo-enzymatic approach.
Stockholm University, Department of Organic Chemistry, Sweden. js@lab12.organ.su.se
J
J
Stawiński
A
A
Kraszewski
D009696:Nucleic Acids / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010712:Phosphatidic Acids / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry
D009696:Nucleic Acids; D009841:Oligonucleotides; D010712:Phosphatidic Acids; D011725:Pyridines; D011743:Pyrimidines