Lack of association between suicide attempt and a polymorphism at the dopamine receptor D4 locus.
Dopaminergic neurotransmission has been implicated in suicidal behaviour. The 48 bp-repeat polymorphism in the gene coding for dopamine receptor D4 was investigated in a sample of suicide attempters (n = 165) and healthy control subjects (n = 99). No association between suicide attempts and this polymorphism was observed. Neither did any significant differences emerge in comparison with control subjects when the suicide attempters were grouped into different diagnostic categories: unipolar (n = 45), anxiety (n = 23), adjustment (n = 37) and personality disorders, cluster B (n = 36). The results suggest that alleles defined by the investigated polymorphism do not have a major impact on suicidal behaviour.
National and Stockholm County Council Centre for Suicide Research and Prevention, National Institute for Psychosocial Factors and Health, Stockholm, Sweden. Maj-Liz.Persson@cnsf.ki.se
M L
ML
Persson
T
T
Geijer
D
D
Wasserman
R
R
Rockah
A
A
Frisch
E
E
Michaelovsky
E G
EG
Jönsson
A
A
Apter
A
A
Weizman
D000275:Adjustment Disorders / Q000235:genetics; D000328:Adult; D001007:Anxiety / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000235:genetics; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4; D012016:Reference Values; D013406:Suicide, Attempted
C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4