[Phosphorus-31-MR spectroscopy imaging in preoperative embolization treatment of meningioma].
OBJECTIVE
31P MR spectroscopic imaging (31P SI) was evaluated in a clinical study as a method for monitoring presurgical devascularization of meningiomas. The aim was to assess noninvasively metabolic alterations in tumor and in healthy brain tissue before and after embolization.


METHODS
Localized 31P MR spectra of the brain were obtained by means of 2D-SI (voxel size: 36 cm3) using a 1,5-T whole-body MR tomograph.


RESULTS
Eleven of 19 patients with intracranial meningiomas examined in this study underwent preoperative embolization therapy; eight patients were examined before and after treatment. After embolization, alterations of pH and of the concentrations of high-energy phosphates (nucleoside-5' triphosphate = NTP, phosphocreatine = PCr), inorganic phosphate (Pi), and membrane constituents were observed in the tumors. A tendency of [Pi] increase and decrease of [NTP], [PCr], and pH predominated, which is explained by ischemic processes after tumor devascularization.


CONCLUSIONS
31P SI is applicable in clinical studies and detects alterations of phosphate metabolism in a meningioma after embolization.
Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum Heidelberg.
M
M
Blankenhorn
P
P
Bachert
W
W
Semmler
G
G
Ende
V
V
Tronnier
G
G
van Kaick
K
K
Sartor
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply; D004621:Embolization, Therapeutic; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008577:Meningeal Neoplasms / Q000098:blood supply* / Q000601:surgery; D008579:Meningioma / Q000098:blood supply* / Q000601:surgery; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D011300:Preoperative Care
D010710:Phosphates
Phosphor-31-MR-spektroskopische Bildgebung bei präoperativer Embolisationstherapie von Meningeomen.