Landomycin A inhibits DNA synthesis and G1/S cell cycle progression.
Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.
Crow
R T
RT
Department of Chemistry, Texas A&M University, College Station 77842, USA.
Rosenbaum
B
B
Smith
R
R
Guo
Y
Y
Ramos
K S
KS
Sulikowski
G A
GA
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D005434:Flow Cytometry; D016193:G1 Phase / Q000187:drug effects*; D051379:Mice; D008969:Molecular Sequence Data; D009130:Muscle, Smooth / Q000187:drug effects; D016196:S Phase / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C064648:landomycin A