Plasma agmatine and platelet imidazoline receptors in depression.
Plasma agmatine concentrations are elevated significantly in depressed patients compared to healthy controls. Treatment with the antidepressant bupropion normalized plasma agmatine levels. Correlational evidence is presented that a change in plasma agmatine levels may lead to similar changes in platelet I1 imidazoline receptors.
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216-4505, USA. AHalaris@psychiatry.umsmed.edu
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D000376:Agmatine / Q000097:blood*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D016642:Bupropion / Q000627:therapeutic use; D015331:Cohort Studies; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics; D054755:Imidazoline Receptors; D015999:Multivariate Analysis; D011955:Receptors, Drug / Q000097:blood*; D012016:Reference Values
D018687:Antidepressive Agents, Second-Generation; D007093:Imidazoles; D054755:Imidazoline Receptors; D011955:Receptors, Drug; D016642:Bupropion; D000376:Agmatine