Effect of angiotensin converting enzyme inhibition on the Doppler waveform in dogs with renal artery stenosis.
Our objective was to investigate whether the angiotensin converting enzyme inhibitor enalaprilat improves detection of hemodynamically significant renal artery stenoses in dogs. Renal artery stenoses of 50 to 99% were surgically created unilaterally in five dogs. Doppler ultrasonographic evaluation was performed at baseline (no stenosis), after creation of the stenosis, and after the administration of enalaprilat. The resistive index increased in the nonstenotic kidney (P < 0.01) but not in the stenotic kidney after administration of enalaprilat. The difference in resistive indices between nonstenotic and stenotic kidneys increased significantly (P < 0.05) after administration of enalaprilat. Measurement of the resistive index after administration of an angiotensin converting enzyme inhibitor in humans may improve the performance of Doppler ultrasonography in detecting hemodynamically significant renal artery stenoses.
Department of Radiology, University of Rochester Medical Center, New York 14642, USA.
R H
RH
Gottlieb
E
E
Zusman
D F
DF
Hartley
D J
DJ
Rubens
S L
SL
Voci
W
W
Robinette
L
L
Melendez
T W
TW
Morris
S
S
Ojha
V
V
Chengazi
E
E
Erturk
E M
EM
Messing
D000806:Angiotensin-Converting Enzyme Inhibitors; D000818:Animals; D004285:Dogs; D015773:Enalaprilat; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018608:Ultrasonography, Doppler / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D015773:Enalaprilat