[The dynamics of neocortical modifications: the dependence on motivational and emotiogenic systems].
A concept is advanced according to which for complete and successive development of membrane and synaptic modifications in the neocortex during the conditioned reflex (CR) elaboration the differentiated changes in impulse flow structure of the motivation and emotion systems of the hypothalamus and reciprocal character of excitatory and inhibitory interactions between them are necessary. Motivation excitation coordinated with repeated activation of synaptic inputs by pairing stimuli contributes to temporary (lasting about hour) increase in somatodendritic electroexcitability of neocortical neurons. It is necessary for maintaining cells in the state of readiness for summation of polymodal excitations during the CR generalization stage. Emotion excitation contributes to long-lasting (about twenty-four hours) increase in synaptic efficacy of excitatory and inhibitory connections which determine a conditioned act during the stage of specialization. Hetero- and homosynaptic facilitation of synaptic transmission lead to global and local character of spatial synchronization of slow activity during these stages. These processes are mainly determined cooperative interaction glutamatergic system with modulator cholin- and monoaminergic (noradren- and serotonin-) systems activating during motivational and emotional behavior components, respectively.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
R G
RG
Kozhedub
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D004644:Emotions / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology; D007858:Learning / Q000502:physiology; D009042:Motivation; D019579:Neocortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology
Dinamika neokortikal'nykh modifikatsiĭ: zavisimost' ot motivatsio- i émotsiogennykh sistem.