Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice.
DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.
Broadbent
J
J
Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health Sciences University, 97201-3098, USA.
Weitemier
A Z
AZ
D000704:Analysis of Variance; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006185:Habituation, Psychophysiologic; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D016291:Dizocilpine Maleate