Human monoclonal antibodies to MN-24 peptide of gp 120 HIV-1.
Human monoclonal IgM antibodies to synthetic peptide MN-24 corresponding to 303-325 residues of gp 120 HIV were obtained. Antibodies are made synthetic by CD5+B lymphocytes and are polyspecific: they react not only with different short peptides but with some macromolecular antigens as well. Anti-MN-24 antibodies possess antigen-binding activity but do not possess virus neutralizing activity. It is suggested that anti-MN-24 antibodies belong to the natural antibodies.
Institute for Viral Preparations of Russian Academy of Medical Sciences, Moscow, Russia.
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Sidorova
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D015699:HIV Envelope Protein gp120 / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000276:immunology; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015699:HIV Envelope Protein gp120; D007075:Immunoglobulin M; D010446:Peptide Fragments