[The role of insulin-like growth factor in polycystic ovary syndrome].
The partnership the insulin-like growth factor (IGF) in women with polycystic ovary syndrome (PCOS) is characterized by mechanisms underlying alterations in the GH/IGF-1, axis. In the pathogenesis exist a synergism markedly enhanced between IGF-1 and insulin, and IGF-1 with LH to increase androgen production, causing a reduced IGFBPs and SHBG production, the resulting hyperandrogenism, within and outside the ovary, may inhibitor follicular maturation and the biosynthesis of estrogen. At the present, the data suggests up to date paracrine, autocrine as well as endocrine actions in the ovary in normal conditions and the lost of this homeostasis can be followed by neuro-endocrine.
P
P
Aquino Carlos
M
M
Hernández Valencia
J J
JJ
Hicks Gómez
M E
ME
Fonseca Yerena
D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D013002:Somatomedins / Q000032:analysis / Q000378:metabolism*
D013002:Somatomedins
Participación del factor de crecimiento insulinoide (IGF), en el síndrome de ovario poliquístico (SOP).