Substance P-immunoreactive boutons closely appose inspiratory protruder hypoglossal motoneurons in the cat.
In anesthetized cats, we recorded intracellularly from 26 hypoglossal motoneurons which were antidromically activated following electrical stimulation of either the medial or lateral branches of the hypoglossal nerve. Twenty-one of these neurons were protruder motoneurons 6 of which had inspiratory activity. Three of the protruder motoneurons with inspiratory activity were filled with Neurobiotin and found to be closely apposed to substance P-like immunoreactive nerve terminals.
Gatti
P J
PJ
Department of Pharmacology, Howard University College of Medicine, 520 W St., NW, Washington, DC 20059, USA. pgatti@howard.edu
Llewellyn-Smith
I J
IJ
Sun
Q J
QJ
Chalmers
J
J
Pilowsky
P
P
D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D002415:Cats; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D007002:Hypoglossal Nerve / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009046:Motor Neurons / Q000166:cytology* / Q000378:metabolism / Q000502:physiology*; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D012143:Respiratory Physiological Phenomena; D013373:Substance P / Q000378:metabolism*
C070614:neurobiotin; D013373:Substance P; D001710:Biotin