Is there a reduced risk of breast cancer among women with hip fractures?
To test the hypothesis that osteoporosis, which results partly from long-term estrogen deficiency, is associated with a lowered risk of breast cancer, a population-based cohort study was performed in Amiens. To ascertain the incidence of breast cancer, 1300 women were followed through after a first hip fracture. Overall, 18 cases of cancer were observed cf. 21.8 expected (standardized incidence ratio (SIR): 0.82; 95% confidence interval (CI): 0.5-1.3). The results are consistent with previous studies which concluded that long-term estrogen deficiency is associated with a reduced risk of developing breast cancer.
Department of Medical Information and Epidemiology, CHU Amiens, France.
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Ganry
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Peng
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Dubreuil
D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology*; D004967:Estrogens / Q000172:deficiency; D005260:Female; D006620:Hip Fractures / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
D004967:Estrogens