Indinavir crystallization and urolithiasis.
The crystallization of indinavir in synthetic urine at different pH values and indinavir concentrations was kinetically studied. It was found that precipitation time notably decreases at urinary pH values above 6.0. The effects of some products as potential crystallization inhibitors were studied. Some natural saponins such as escin and glycyrrhizic acid provoked a notable increase in the precipitation time of indinavir, this pointing out their possible use to prevent renal tubular solid deposition.
Grases
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F
Laboratory of Urolithiasis Research, University of Illes Balears, Spain.
Costa-Bauzá
A
A
García-González
R
R
Payeras
A
A
Bassa
A
A
Torres
J J
JJ
Conte
A
A
D011232:Chemical Precipitation; D003460:Crystallization; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000737:chemistry / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019469:Indinavir / Q000009:adverse effects / Q000737:chemistry / Q000652:urine*; D007669:Kidney Calculi / Q000139:chemically induced
D017320:HIV Protease Inhibitors; D019469:Indinavir