Prevalence of antibodies to human parvovirus B19 nonstructural protein in persons with various clinical outcomes following B19 infection.
Persistent infections with human parvovirus B19 (B19) associated with debilitating chronic disease have been described, although evidence linking B19 to these more unusual clinical outcomes has been inconclusive. Recent reports have suggested that the development of antibodies to the B19 nonstructural protein (NS1) following B19 infection might be linked to development of severe arthropathy and chronic infection. To confirm these findings, the C-terminal region of the NS1 protein was expressed for use in Western blot assays for detection of anti-NS1 IgG antibodies in human serum. Among 91 persons tested, 0 of 20 not previously infected with B19, 9(36%) of 25 with past B19 infection, and 5 (12.5%) of 40 with recent B19 infection, had detectable anti-NS1 antibodies. Of 6 persons with chronic B19 infection, 2 had detectable antibodies to NS1. The presence of anti-NS1 antibodies did not appear to correlate with unusual clinical outcomes or chronic B19 infection.
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA.
L P
LP
Jones
D D
DD
Erdman
L J
LJ
Anderson
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D015153:Blotting, Western; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010322:Parvoviridae Infections / Q000276:immunology* / Q000821:virology; D016732:Parvovirus B19, Human / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000276:immunology; D011247:Pregnancy; D011817:Rabbits; D017361:Viral Nonstructural Proteins / Q000276:immunology*
D000914:Antibodies, Viral; C106202:NS1 protein, parvovirus; D017361:Viral Nonstructural Proteins