Growth hormone-secreting pituitary adenomas in childhood and adolescence: features and results of transnasal surgery.
OBJECTIVE
Pituitary tumors causing gigantism are rare in childhood and adolescence. In a review of 2367 patients with pituitary adenomas who were treated between 1970 and 1997, we found 15 cases (0.63%, 9 male and 6 female patients) of growth hormone-secreting pituitary adenomas in patients who were less than 20 years of age at the time of surgery, and we compared their characteristics with those of adenomas in an adult group.


METHODS
Patients were grouped according to their ages at the first operation, with five patients (33.3%) in the prepubescent group (0-11 yr), eight (53.3%) in the pubescent group (12-17 yr), and two (13.3%) in the postpubescent group (18-19 yr). All 15 patients exhibited the typical symptoms of growth hormone oversecretion. The incidence of hyperprolactinemia among patients with prepubescent onset was 66.7%. Radiological examinations demonstrated microadenomas in 4 patients (26.7%) and macroadenomas in 11 patients (73.3%). The mean follow-up period was 73.5 months.


RESULTS
Direct transnasal explorations were performed for all patients. Tumor invasion into the cavernous sinus was observed in six patients (40%). Radical tumor resection was performed for four patients (80%) in the prepubescent group, for five patients (62.5%) in the pubescent group, and for neither patient in the postpubescent group. Surgical morbidity was caused by permanent diabetes insipidus in three patients (20%). Rapid growth was postoperatively improved in 80% of the prepubescent age group. The recurrence rate was 13.3% (2 of 15 patients).


CONCLUSIONS
Transnasal pituitary surgery was found to be as safe in pediatric patients with gigantism as in adults. Growth hormone-secreting pituitary adenomas in childhood and adolescence were more likely to be invasive or aggressive than were those in adulthood. The clinical biological characteristics for children were different from those for adults.
Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan.
T
T
Abe
L A
LA
Tara
D K
DK
Lüdecke
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D008866:Microsurgery; D009361:Neoplasm Invasiveness; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D011388:Prolactin / Q000097:blood
D019382:Human Growth Hormone; D011388:Prolactin