Extrahepatic drug metabolizing enzymes.
Drug metabolizing enzymes are known to be present and active in most extrahepatic tissues. In this review, evidence is presented that expression and activity of several extrahepatic drug-metabolizing enzymes are regulated in unique ways, which may be associated with tissue functions and activities. In several instances evidence is offered that hormonal effects may be regulated through tissue specific distribution and/or responses of transcription factors.
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
J
J
Kapitulnik
H W
HW
Strobel
D000818:Animals; D001921:Brain / Q000201:enzymology; D001943:Breast Neoplasms / Q000201:enzymology; D002784:Cholesterol / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006728:Hormones / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D010053:Ovary / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D006728:Hormones; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D014453:Glucuronosyltransferase; D005978:Glutathione