Synthesis of reduced collagen crosslinks.
A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.
van den Nieuwendijk
A M
AM
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, The Netherlands.
Benningshof
J C
JC
Wegmann
V
V
Bank
R A
RA
te Koppele
J M
JM
Brussee
J
J
van der Gen
A
A
D000478:Alkylation; D003094:Collagen / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D003432:Cross-Linking Reagents; D004151:Dipeptides / Q000138:chemical synthesis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D003432:Cross-Linking Reagents; D004151:Dipeptides; C007428:5,5'-dihydroxylysylnorleucine; C010991:delta-hydroxylysylnorleucine; C002961:lysinenorleucine; D003094:Collagen