Interictal spike localization using a standard realistic head model: simulations and analysis of clinical data.
OBJECTIVE
In this paper realistic and standard realistic head models were applied to neural source localization.


METHODS
Three different triangulated head structures; the brain, the skull and the scalp were constructed from MRI information of each patient. For each subject the exact positions of the electrodes were digitized.


RESULTS
The influence of the number of triangles and of the skull conductivity on the accuracy of the method was tested. The use of a standard realistic head model instead of spherical models is proposed in cases where detailed MRI information is not available, and the accuracy of this procedure is tested with dipole simulations. These techniques were applied also to EEG signals from 3 patients with focal epilepsy. In all cases the neural activity was assumed to be confined to a small portion of cortical tissue, so that the neural generator was approximated to a current dipole. The realistic head model localization is discussed on the basis of neuroimaging information.


CONCLUSIONS
We show that the standard realistic head model is two or 3 times better than the spherical model for dipole localization and we propose it as a good alternative to the spherical model for EEG data processing, in cases where full MRI information is not available.
Silva
C
C
Institute of Biophysics and Biomedical Engineering, University of Lisbon, Portugal.
Almeida
R
R
Oostendorp
T
T
Ducla-Soares
E
E
Foreid
J P
JP
Pimentel
T
T
D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003198:Computer Simulation; D004569:Electroencephalography; D006801:Humans; D008959:Models, Neurological; D012984:Software