[Renal function and functional renal reserve in adolescents who acquired minimal change nephrotic syndrome in childhood].
OBJECTIVE
The aim of this study was to evaluate glomerular filtration rate (GFR) and renal functional reserve (RR) in young patients after diagnosis of minimal change nephrotic syndrome (MCNS) during childhood.


METHODS
GFR and RR were evaluated in 15 young patients (10 female) diagnosis of childhood MCNS 18.5 +/- 4 years before. Creatinine clearance (CC) was measured before and after an acute protein load to determine GFR and RR. Based on the tendency towards relapses, the study subjects were divided into two groups: Group A had less than five relapses and group B five or more relapses. Study subjects (groups A and B) and control subjects (group C) were matched for sex and age.


RESULTS
Group B showed a higher GFR than groups A and C (group B = 133.9 +/- 16.26 ml/min/1.73 m2, group A = 107.91 +/- 18.19 ml/min/1.73m2; p = 0.014, group C = 113.89 +/- 13.17 ml/min/1.73m2, p = 0.015). RR was significantly lower (absolute and relative) in group B than in group C (group B = 10.9 +/- 15.46 ml/min/1.73m2, group C = 38.58 +/- 21.47 ml/min/1.73m2, p = 0.016 and group B = 8.56 +/- 11.75%, group C = 34.35 +/- 21.43%, p = 0.016, respectively).


CONCLUSIONS
After childhood MCNS, young patients who presented more than five relapses showed an increase in GFR and a decrease in RR.
Antón Gamero
M
M
Departamento de Pediatría, Hospital Central de Asturias, Universidad de Oviedo.
Menéndez Cuervo
S
S
Orejas Rodríguez-Arango
G
G
Málaga Guerrero
S
S
D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology*; D008297:Male; D009402:Nephrosis, Lipoid / Q000175:diagnosis* / Q000503:physiopathology*; D012008:Recurrence; D012079:Renal Circulation / Q000502:physiology
Función renal y reserva funcional renal en jóvenes que padecieron síndrome nefrótico a cambios mínimos en la infancia.