Kainic acid-induced inducible cyclooxygenase and c-Jun phosphorylation in the rat hippocampal formation.
Inducible cyclooxygenase (COX-2) was transiently induced in the neurons throughout the entire hippocampus between 6 and 24 h after injection of kainic acid (KA). The induction of COX-2 correlated more closely with the induction of c-Jun than with that of c-Fos. Phosphorylated c-Jun was induced 6-12 h after in the CA3 pyramidal neurons, which undergo apoptosis. Almost all of neurons with phosphorylated c-Jun were colocalized with COX-2. These results suggest that COX-2 and c-Jun phosphorylation may participate in KA-induced neurodegeneration.
Department of Neurobiology, Kyoto Pharmaceutical University, Yamashina, Kyoto 607-8412, Japan. matsuoka@nki.rfmh.org
Y
Y
Matsuoka
M
M
Okazaki
Y
Y
Kitamura
K
K
Takata
I
I
Tooyama
H
H
Kimura
T
T
Taniguchi
D000818:Animals; D051546:Cyclooxygenase 2; D004790:Enzyme Induction; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007527:Isoenzymes / Q000096:biosynthesis / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009410:Nerve Degeneration; D010766:Phosphorylation; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000187:drug effects*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D007527:Isoenzymes; D016755:Proto-Oncogene Proteins c-jun; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D007608:Kainic Acid