Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.
A unilateral microinjection of either histamine or kainic acid was made into the medial vestibular nucleus of rats, eliciting robust barrel rotations that were evaluated by an elevated body-rotation test. Systemic pretreatment with betahistine or GT-2016 significantly attenuated the kainic acid-induced barrel rotations. These data indicate that the animal model described herein may represent a new model to identify novel drugs with potential antivertigo properties.
O'Neill
A B
AB
Neurological and Urological Diseases Research (D4ND), Abbott Laboratories, Abbott Park, IL, USA.
Pan
J B
JB
Sullivan
J P
JP
Brioni
J D
JD
D000818:Animals; D001621:Betahistine / Q000494:pharmacology; D004195:Disease Models, Animal; D004347:Drug Interactions; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D017442:Histamine Agonists / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D051381:Rats; D020318:Rats, Long-Evans; D015837:Vestibular Diseases / Q000139:chemically induced*; D014726:Vestibular Nuclei / Q000187:drug effects* / Q000473:pathology
C096758:4-(1-cyclohexylpentanoyl-4-piperidyl)-1H-imidazole; D018690:Excitatory Amino Acid Agonists; D017442:Histamine Agonists; D006633:Histamine Antagonists; D007093:Imidazoles; D006632:Histamine; D007608:Kainic Acid; D001621:Betahistine