Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis.
The extract of the pericarp of castor bean (Ricinus communis) showed some typical central nervous system stimulant effects when administered to mice. The animals became exophthalmic, presented tremors and clonic seizures and died a few minutes after receiving larger doses of the extract. At lower doses the extract improved memory consolidation and showed some neuroleptic-like properties, such as a decrease in exploratory behavior and catalepsy. The memory-improving effect and the seizure-eliciting properties of the extract were also observed with the administration of ricinine, a neutral alkaloid isolated from the extract. However, the neuroleptic-like properties of the extract were not observed with ricinine. As the therapeutic index of ricinine is of the order of 200, the compound may be considered as a promising cognition-enhancing drug that may be used for the treatment of human amnesias.
Dep. Fisiologia e Dep. Farmacolgia, Univ. Fed. Paraná, Curitiba, PR, Brazil.
A C
AC
Ferraz
M E
ME
Angelucci
M L
ML
Da Costa
I R
IR
Batista
B H
BH
De Oliveira
C
C
Da Cunha
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000494:pharmacology*; D005094:Exophthalmos / Q000139:chemically induced; D018737:Hand Strength / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010947:Plants, Toxic; D011680:Pupil / Q000187:drug effects; D011728:Pyridones; D012278:Ricinus / Q000737:chemistry*
D000470:Alkaloids; D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D010936:Plant Extracts; D011728:Pyridones; C019550:ricinine