gamma delta T-cells may interfere with a productive immune response in Plasmodium yoelii infections.
Mice lacking alpha beta T-cells or gamma delta T-cells were infected with Plasmodium yoelii 17X NL (non-lethal) and followed for parasitaemia and cytokine production. While the parasitaemia in wild type mice resolved after reaching a peak value of 30 to 50%, it persisted in the -alpha beta T-cell mice until death. However, in the -gamma delta T-cell mice the peak parasitaemia was 12.5% of the levels seen in the wild type and -alpha beta T-cell mice and resolved faster than in the wild type mice. Higher levels of IL-10 and IFN-gamma were consistently found in the wild type and -gamma delta T-cell mice but not in the -alpha beta T-cell mice.
Kopacz
J
J
Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Public Health, Baltimore, MD 21205, USA.
Kumar
N
N
D000818:Animals; D016207:Cytokines / Q000032:analysis; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout / Q000276:immunology / Q000469:parasitology; D018512:Parasitemia / Q000276:immunology*; D010967:Plasmodium yoelii / Q000276:immunology* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013997:Time Factors
D016207:Cytokines