Synthesis of 4-hydroxy-1-thiocoumarin derivatives-1: an efficient synthesis of thioflocoumafen.
An efficient procedure for the preparation of 4-hydroxy-3-{1,2,3,4-tetra-hydro-3-[4-(4-triflu-oromethylbenzyl oxy)phenyl]-1-naphthyl}thiocoumarin (thioflocoumafen, 1a and 1b) is described. The key step in the synthesis involves the condensation reaction of 3-(4-methoxyphenyl)-1-tetralol (2) with 4-hydroxy-1-thiocoumarin (3).
Jung
J C
JC
Department of Chemistry, Chungbuk National University, Cheongju, Korea.
Kim
J C
JC
Park
O S
OS
Jang
B S
BS
D015110:4-Hydroxycoumarins / Q000138:chemical synthesis*; D000925:Anticoagulants / Q000138:chemical synthesis*; D002622:Chemistry, Agricultural / Q000379:methods; D003374:Coumarins / Q000138:chemical synthesis*; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis*
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D003374:Coumarins; D013764:Tetrahydronaphthalenes; C122105:thioflocoumafen