Hemodiafiltration for vancomycin overdose in a neonate with end-stage renal failure.
We describe continuous venovenous hemodiafiltration (CVVHD) with a high-flux membrane as a novel treatment modality for vancomycin overdose associated with renal insufficiency. CVVHD was used in a 6-day-old male with a solitary hypodysplastic kidney, suspected sepsis, and anuric renal failure who subsequently received an accidental tenfold overdose of vancomycin. We furthermore present evidence for the importance of countercurrent dialysis in addition to continuous hemofiltration for optimal vancomycin removal.
Goebel
J
J
Department of Pediatrics, Tulane Medical School and Tulane Hospital for Children New Orleans, Louisiana, USA.
Ananth
M
M
Lewy
J E
JE
D062787:Drug Overdose; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000628:therapy*; D008297:Male; D014640:Vancomycin / Q000506:poisoning*
D014640:Vancomycin