[An information system for automated cytogenetic image processing: analysis of interphase chromatin of nerve cells of embryonic brain of rats with varying nervous system excitability].
To reveal a relationship between the genetically determined excitability of rats and the structural-functional chromosome organization in their neurone nuclei a computer information system has been developed to classify the neurone nuclei according to their specific DNA image cytometry features. The nuclear features, such as size, shape, and DNA content, are calculated, along with features describing characteristics of chromatin with the nucleus. The neural and glial cells are separated according to the rule based expert system approach with the use of a nuclear feature vector. The DNA image processing is performed and a feature vector consisting of normalized measures of the neurone nucleus chromatin region descriptors is extracted. The results indicate a relationship between the peculiarities of the nervous system and the structural-functional state of the chromosomal apparatus.
Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
K N
KN
Dudkin
S V
SV
Mironov
N A
NA
Diuzhikova
N G
NG
Lopatina
D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology*; D003582:Cytogenetics / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D007256:Information Systems; D009424:Nervous System Physiological Phenomena; D051381:Rats; D013045:Species Specificity
Informatsionnaia sistema dlia avtomaticheskoĭ obrabotki tsitogeneticheskikh dannykh: analiz interfaznogo khromatina nervnykh kletok mozga émbrionov krys s razlichnoĭ vozbudimost'iu nervnoĭ sistemy.