Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues.
Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.
Yang
L
L
Merck Research Laboratories, Rahway, NJ 07065, USA.
Morriello
G
G
Leung
K
K
Jacks
T
T
Cheng
K
K
Schleim
K D
KD
Smith
R
R
Patchett
A A
AA
D000818:Animals; D001682:Biological Availability; D004285:Dogs; D013006:Growth Hormone / Q000138:chemical synthesis* / Q000378:metabolism*; D008956:Models, Chemical; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D013997:Time Factors
D013844:Thiazoles; D013006:Growth Hormone