Oxidative stress induced in pathologies: the role of antioxidants.
Exposure to oxidant molecules issued from the environment (pollution, radiation), nutrition, or pathologies can generate reactive oxygen species (ROS for example, H2O2, O2-, OH). These free radicals can alter DNA, proteins and/or membrane phospholipids. Depletion of intracellular antioxidants in acute oxidative stress or in various diseases increases intracellular ROS accumulation. This in turn is responsible for several chronic pathologies including cancer, neurodegenerative or cardiovascular pathologies. Thus, to prevent against cellular damages associated with oxidative stress it is important to balance the ratio of antioxidants to oxidants by supplementation or by cell induction of antioxidants.
Laboratoire de Pharmacologie Cellulaire et Moleculaire, UMR CNRS 8612, Université de Paris XI, Faculté de Pharmacie, France.
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Tapiero
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004194:Disease; D006801:Humans; D016877:Oxidants / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects
D000975:Antioxidants; D016877:Oxidants