Spectroscopic studies of PhTX facilitated cation movement across membranes.
Philanthotoxins, noncompetitive inhibitors of the nicotinic acetylcholine receptor and various glutamate receptors, were found to be capable of mediating cation transport across lipid bilayers. With respect to the relatively weak binding constants of these amphiphilic polyamines to neuronal receptor proteins, this finding implies that their interaction with cell membranes might have to be considered in addition to that with protein receptors to fully understand the molecular mechanism of these neurotoxins.
Department of Chemistry, Columbia University, New York, NY 10027, USA.
X
X
Huang
B
B
Borhan
S
S
Matile
K
K
Nakanishi
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D002412:Cations / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects; D004530:Egg Yolk / Q000737:chemistry; D006096:Gramicidin / Q000493:pharmacokinetics; D007476:Ionophores / Q000493:pharmacokinetics; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000737:chemistry; D011073:Polyamines; D013050:Spectrometry, Fluorescence; D013096:Spermine / Q000493:pharmacokinetics; D013997:Time Factors; D014634:Valinomycin / Q000493:pharmacokinetics; D014862:Wasp Venoms / Q000378:metabolism* / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D002412:Cations; D007476:Ionophores; D010713:Phosphatidylcholines; D011073:Polyamines; D014862:Wasp Venoms; D006096:Gramicidin; D014634:Valinomycin; D013096:Spermine; C034092:delta-philanthotoxin