Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus.
Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel metabotropic L-glutamate receptors in hippocampal long-term potentiation and long-term depression.
Department of Anatomy, MRC Centre for Synaptic Plasticity, University of Bristol School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK. Z.A.Bortolotto@bris.ac.uk
Z A
ZA
Bortolotto
S M
SM
Fitzjohn
G L
GL
Collingridge
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D018094:Receptors, Metabotropic Glutamate