Oral bedtime cornstarch supplementation reduces the risk for nocturnal hypoglycaemia in young children with type 1 diabetes.
The effect of oral cornstarch supplementation was evaluated in 14 pre-school children with type 1 diabetes in a randomized, double-blind, placebo-controlled trial. The children received cornstarch (0.3 g/kg) or placebo at bedtime on five occasions each, and their blood glucose concentrations were measured at bedtime, at 02.00 h and in the morning. The mean nocturnal blood glucose concentration (at 02.00 h) was 2.2 mmol/L higher and the number of blood glucose concentrations below 5 mmol/L were reduced by 64% when cornstarch had been ingested at bedtime. We conclude that cornstarch may be used in pre-school children with type 1 diabetes to reduce the risk for nocturnal hypoglycaemia.
Department of Paediatrics, Orebro Medical Centre Hospital, Sweden.
I
I
Detlofson
M
M
Kroon
J
J
Aman
D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004435:Eating; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D008297:Male; D012720:Severity of Illness Index; D013213:Starch / Q000627:therapeutic use*; D013997:Time Factors
D001786:Blood Glucose; D013213:Starch