1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
Georgetown University Medical Center, Drug Discovery Laboratory, Institute for Cognitive & Computational Sciences, Washington, DC 20007-2197, USA.
A P
AP
Kozikowski
G L
GL
Araldi
W
W
Tückmantel
S
S
Pshenichkin
E
E
Surina
J T
JT
Wroblewski
D000818:Animals; D016466:CHO Cells; D016923:Cell Death; D006224:Cricetinae; D018690:Excitatory Amino Acid Agonists / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D016202:N-Methylaspartate / Q000633:toxicity; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
C120942:1,4-diaminopyrrolidine-2,4-dicarboxylic acid; D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate; D016202:N-Methylaspartate; D011392:Proline