Triple pituitary adenoma in Cushing's disease: case report.
A case of a triple pituitary adenoma identified in a surgically removed pituitary gland from a 52-year-old woman operated on for Cushing's disease is presented. The histology revealed 3 distinctly separate microadenomas, 1 corticotroph and 2 immunoreactive for prolactin (PRL). The latter were apparently silent, since the serum PRL levels were within normal range. The problems associated with the inability to identify multiple adenomas pre-operatively and the possible failure of selective transsphenoidal adenomectomy in case of multiple adenomas are emphasised.
Department of Pathology, General Hospital of Athens G. Gernimatas, Greece.
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E
Pantelia
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G
Kontogeorgos
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G
Piaditis
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D
Rologis
D000237:Adenoma, Basophil / Q000473:pathology* / Q000601:surgery; D003480:Cushing Syndrome / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery; D015175:Prolactinoma / Q000473:pathology* / Q000601:surgery