Serotonin uptake stimulating peptide found in plasma of normal individuals and in some autistic urines.
We have isolated a tripeptide from normal plasma and autistic urines which stimulates the uptake of serotonin (5-HT) into platelets. This peptide was purified by high-performance liquid chromatography (HPLC) and characterized by sequenation and mass-spectrometry. Synthetic peptide showed co-chromatography with the biological sample in the HPLC systems used. Close to 60% of the autistic children diagnosed using the Diagnostic Statistical Manual III-R had an increased HPLC peak eluting like this peptide in their urines compared with controls.
Research Institute, University of Oslo, Rikshospitalet, Norway.
O S
OS
Pedersen
Y
Y
Liu
K L
KL
Reichelt
D000595:Amino Acid Sequence; D001321:Autistic Disorder / Q000652:urine*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002648:Child; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D010455:Peptides / Q000097:blood* / Q000494:pharmacology / Q000652:urine*; D012016:Reference Values; D012701:Serotonin / Q000493:pharmacokinetics*
D010455:Peptides; D012701:Serotonin