Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH.
A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.
Meyers
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EN
Department of Anatomy and Program in Developmental Biology, School of Medicine, and Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA.
Martin
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GR
D000818:Animals; D019521:Body Patterning; D002642:Chick Embryo / Q000254:growth & development* / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism; D004627:Embryonic Induction; D005314:Embryonic and Fetal Development; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000196:embryology; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D055458:Left-Right Determination Factors; D008168:Lung / Q000002:abnormalities / Q000196:embryology; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D009154:Mutation; D055457:Nodal Protein; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000502:physiology; D000097577:Homeobox Protein PITX2
D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D055458:Left-Right Determination Factors; D055457:Nodal Protein; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; D011506:Proteins; D011994:Recombinant Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D000097577:Homeobox Protein PITX2; C496457:Fgf8 protein, mouse; C526008:Nodal protein, mouse; C101485:homeobox protein PITX1; C433629:homeobox protein PITX3