[An example of dominant inheritance in the transmission of chronic open-angle glaucoma. Apropos of an Algerian family].
BACKGROUND
The hereditary nature of chronic open-angle glaucoma (COAG) is recognized in 20 to 25% of the cases. Disease prevalence among relatives of patients with glaucoma is higher than in the general population. Several inheritance modes may co-exist.


METHODS
Forty-seven members of a family living in eastern Algeria were studied. Three generations were examined.


RESULTS
There were 15 cases of COAG (8 men and 7 women) in this family, i.e. 32% of the members. Affected members were aged from 23 to 80 years.


CONCLUSIONS
An epidemiologic, clinical and genetic analysis of this family provided information concerning the transmission modes of COAG.


CONCLUSIONS
It is highly likely that in this family, COAG was transmitted by autosomal dominant inheritance with strong penetrance. Genetic analysis excluded locus GLC1A mutation, confirming the heterogeneous nature of COAG inheritance.
CHU Béni-Messous, Alger.
O
O
Ouhadj
N
N
Degheb
M T
MT
Nouri
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000462:Algeria; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002908:Chronic Disease; D005260:Female; D005799:Genes, Dominant; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D015995:Prevalence
Un exemple d'hérédité dominante pour la transmission de GCAO. A propos d'une famille algérienne.