Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study.
We performed a cross-sectional case-control study among 295 subjects with dementia and 406 control subjects drawn from participants of the Rotterdam Study, a population-based cohort study among subjects aged 55 years or over, and from participants of the Rotterdam Stroke Databank, a hospital-based stroke registry, to evaluate the association of the factor V Leiden mutation and activated protein C (APC) response with dementia and its subtypes. The risk of dementia was 2.11-fold increased among carriers of factor V Leiden mutation relative to subjects lacking factor V Leiden mutation (95% confidence interval, CI, 0.93-4.77). The increased risks of vascular dementia and of Alzheimer's disease were 4.28 (95% CI 1.26-14.5) and 2.15 (95% CI 0.82-5.63), respectively. No association was found for APC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia.
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands. m.l.bots@jc.azu.nl
M L
ML
Bots
F
F
van Kooten
M M
MM
Breteler
P E
PE
Slagboom
A
A
Hofman
F
F
Haverkate
P
P
Meijer
P J
PJ
Koudstaal
D E
DE
Grobbee
C
C
Kluft
D020016:Activated Protein C Resistance / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D015140:Dementia, Vascular / Q000235:genetics; D005165:Factor V / Q000009:adverse effects / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D017354:Point Mutation; D011446:Prospective Studies; D012307:Risk Factors
C095381:factor V Leiden; D005165:Factor V