Anticancer drug design based on plant-derived natural products.
This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis. Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.
Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, Nc 27599-7360, USA.
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives; D003078:Colchicine / Q000031:analogs & derivatives; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005047:Etoposide / Q000031:analogs & derivatives / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D010944:Plants / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D050257:Tubulin Modulators
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D005419:Flavonoids; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D050257:Tubulin Modulators; D005047:Etoposide; D003078:Colchicine; D002166:Camptothecin