A chronic ethanol-feeding study in rhesus monkeys.
This study describes the effect of chronic ethanol-feeding in rhesus monkeys. Animals which were maintained on a diet containing 18:2n-6 and 18:3n-3 as 1.4 and 0.08% of the calories, respectively, and consumed alcohol (mean 2.6 g kg(-1) d(-1)) had decreased amounts of 20:4n-6 and 22:6n-3 in their livers and plasma lipids compared with controls. Alcohol consumption did not appear to effect the absorption of 2H(5)-18:2n-6 and 18:3n-3 esters into the blood following an oral dose. There was an increase in 2H5 enrichment in plasma 20:4n-6 and 22:6n-3, indicating that alcohol may have increased production of these fatty acids. There was a greater concentration of 4-hydroxynonenal in the plasma of alcohol-exposed monkeys compared to controls.
U.S. Department of Agriculture, Human Nutrition Research Center, Beltsville, Maryland, USA. Pawlosky@bhnrc.usda.gov
R J
RJ
Pawlosky
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N
Salem
D000437:Alcoholism / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D003903:Deuterium; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D011865:Radioisotope Dilution Technique
D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D008055:Lipids; D003903:Deuterium