[Adhesive and sealing effects of TO-193 on tissues and organs in various experimental models].
We studied the adhesive and sealing effects of sheet style fibrin adhesive, TO-193 (TachoComb), on some tissues and organs, comparing them with those of sheet style collagen agent, collagen sponge, Novacol, and Avitene and liquid fibrin adhesive agent, Beriplast P. TO-193 showed more a potent adhesive effect on liver than the sheet style collagen agents and was more potent on bone and skin than the liquid fibrin adhesive agent. Furthermore, TO-193 had a potent sealing effect at the site of incomplete suture immediately after application on a motile organ such as lung and stomach. These effects may be partly attributable to rapid expression of the effect due to the presence of a high concentration of fibrinogen on coverage. Enhancement of fibrin penetrability to the tissues by compression and inhibition of cleavage of coverage by the collagen sponge also may be participating in the effects of TO-193. These results suggest that TO-193 will be a valuable adhesive and sealing agent.
Research Laboratories, Torii Pharmaceutical Co., Ltd., Chiba, Japan.
S
S
Kanno
H
H
Yamazaki
S
S
Kashiwabara
H
H
Uchiyama
Y
Y
Maekawa
G
G
Ito
T
T
Muto
K
K
Kariya
T
T
Kojima
Y
Y
Koshiyama
M
M
Oda
M
M
Kurumi
D000818:Animals; D007611:Aprotinin; D004285:Dogs; D004338:Drug Combinations; D005069:Evaluation Studies as Topic; D005176:Factor XIII / Q000502:physiology; D005260:Female; D005269:Femur; D005340:Fibrinogen; D006168:Guinea Pigs; D008099:Liver; D008168:Lung; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012867:Skin; D013270:Stomach; D013917:Thrombin; D014014:Tissue Adhesives
D004338:Drug Combinations; D014014:Tissue Adhesives; C093991:tachocomb; D005340:Fibrinogen; D005176:Factor XIII; D007611:Aprotinin; D013917:Thrombin