Magnetoencephalographic mapping of the language-specific cortex.
OBJECTIVE
In this paper the authors introduce a novel use of magnetoencephalography (MEG) for noninvasive mapping of language-specific cortex in individual patients and in healthy volunteers.


METHODS
The authors describe a series of six experiments in which normative MEG data were collected and the reliability, validity, and topographical accuracy of the data were assessed in patients who had also undergone the Wada procedure or language mapping through intraoperative cortical stimulation.


CONCLUSIONS
Findings include: 1) receptive language-specific areas can be reliably activated by simple language tasks and this activation can be readily recorded in short MEG sessions; 2) MEG-derived maps of each individual are reliable because they remain stable over time and are independent of whether auditory or visual stimuli are used to activate the brain; and 3) these maps are also valid because they concur with results of the Wada procedure in assessing hemispheric dominance for language and with the results of cortical stimulation in identifying the precise topography of receptive language regions within the dominant hemisphere. Although the MEG mapping technique should be further refined, it has been shown to be efficacious by correctly identifying the language-dominant hemisphere and specific language-related regions within this hemisphere. Further development of the technique may render it a valuable adjunct for routine presurgical planning in many patients who harbor tumors or have epilepsy.
Papanicolaou
A C
AC
Department of Neurosurgery, The University of Texas-Houston Medical School, USA. apapanic@heart.med.uth.tmc.edu
Simos
P G
PG
Breier
J I
JI
Zouridakis
G
G
Willmore
L J
LJ
Wheless
J W
JW
Constantinou
J E
JE
Maggio
W W
WW
Gormley
W B
WB
D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001303:Auditory Cortex / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000503:physiopathology; D002540:Cerebral Cortex / Q000502:physiology*; D003560:Cysts / Q000503:physiopathology; D004410:Dyslexia / Q000503:physiopathology; D004827:Epilepsy / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D005910:Glioma / Q000503:physiopathology; D006392:Hemangioma, Cavernous / Q000503:physiopathology; D006801:Humans; D007802:Language; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D016343:Monitoring, Intraoperative; D009778:Occipital Lobe / Q000502:physiology; D010775:Photic Stimulation; D015203:Reproducibility of Results; D013702:Temporal Lobe / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology