hnRNP complexes: composition, structure, and function.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are predominantly nuclear RNA-binding proteins that form complexes with RNA polymerase II transcripts. These proteins function in a staggering array of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover. Recent studies suggest that several fundamental characteristics of hnRNPs account for their involvement in multiple regulatory pathways.
Krecic
A M
AM
Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA.
Swanson
M S
MS
D000818:Animals; D001483:Base Sequence; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D012322:RNA Precursors / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D012261:Ribonucleoproteins / Q000737:chemistry / Q000502:physiology*; D014158:Transcription, Genetic
D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012322:RNA Precursors; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins