Prevention of hypotension after spinal anesthesia for cesarean section: dextran 40 versus lactated Ringer's solution.
BACKGROUND
This study was designed to compare the efficacy of 10% dextran 40 with lactated Ringer's (LR) solution in reducing the incidence and severity of hypotension after spinal anesthesia for Cesarean section.


METHODS
Sixty ASA grade I patients scheduled for Cesarean section were randomized into two groups in a double-blind fashion to receive either 500 ml of dextran 40 or 1000 ml of LR solution prior to induction of spinal anesthesia.


RESULTS
The incidence of hypotension was 16 in 30 (53.3%) in the LR solution group and 8 in 30 (26.7%) in the dextran group (P < 0.05). The required dose of ephedrine for treatment of hypotension was significantly greater in the LR solution group than in the dextran group (15.5 mg versus 3.2 mg, P < 0.05). Neonatal outcome, as determined by Apgar score, was good and similar in both groups.


CONCLUSIONS
We concluded that 500 ml of dextran 40 is more effective than 1000 ml of lactated Ringer's solution in reducing the incidence of hypotension induced by spinal anesthesia.
Lin
C S
CS
Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
Lin
T Y
TY
Huang
C H
CH
Lin
Y H
YH
Lin
C R
CR
Chan
W H
WH
Tsai
S K
SK
D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D002585:Cesarean Section; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007552:Isotonic Solutions / Q000494:pharmacology; D011247:Pregnancy; D000077325:Ringer's Lactate
D003911:Dextrans; D007552:Isotonic Solutions; D000077325:Ringer's Lactate