Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1.
The human teratocarcinoma derived growth factor 1 (TDGF1) gene maps on chromosome (Chr) 3p21.3. One pseudogene (TDGF3) maps on Chr Xq21-->q22. We now report the nucleotide sequence and chromosome location of three additional TDGF pseudogenes. The three new sequences (TDGF2, TDGF4 and TDGF5) are truncated at the 5' end and have accumulated several point mutations, deletions and insertions. TDGF2, TDGF4 and TDGF6 map on Chrs 2q37, 6p25 and 3q22, respectively. Finally, Southern blot analysis of DNA from normal individuals shows a highly variable restriction pattern of the TDGF sequences.
International Institute of Genetics and Biophysics, CNR, Naples, Italy.
B
B
Scognamiglio
G
G
Baldassarre
C
C
Cassano
M
M
Tucci
N
N
Montuori
R
R
Dono
G
G
Lembo
A
A
Barra
C T
CT
Lago
G
G
Viglietto
M
M
Rocchi
M G
MG
Persico
D020087:Alu Elements / Q000235:genetics; D001483:Base Sequence; D015139:Blotting, Southern; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D002877:Chromosomes, Human / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D003001:Cloning, Molecular; D004815:Epidermal Growth Factor; D005091:Exons / Q000235:genetics; D058851:GPI-Linked Proteins; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D036341:Intercellular Signaling Peptides and Proteins; D007438:Introns / Q000235:genetics; D008562:Membrane Glycoproteins; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D020161:Physical Chromosome Mapping; D011544:Pseudogenes / Q000235:genetics*; D013698:Templates, Genetic
D058851:GPI-Linked Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C070636:TDGF1 protein, human; D004815:Epidermal Growth Factor