A case of thrombopoietin-producing ovarian carcinoma confirmed by immunohistochemistry.
A case of ovarian carcinoma with thrombopoietin production is reported. A 49-year-old Japanese woman had serous cystadenocarcinoma of the right ovary with peritoneal spread. The platelet count was elevated to 432 x 10(9)/L. Enzyme-linked immunosorbent assay of the serum demonstrated remarkably high levels of thrombopoietin (2.96 fmol/ml). Immunohistochemical examination using an antibody specific for thrombopoietin revealed positive staining in the carcinoma cells, confirming thrombopoietin production.
Department of Obstetrics and Gynecology, Handa City Hospital, Handa, 475-8599, Japan.
M
M
Furuhashi
Y
Y
Miyabe
H
H
Oda
D018284:Cystadenocarcinoma, Serous / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000378:metabolism*; D013926:Thrombopoietin / Q000032:analysis / Q000096:biosynthesis*
D013926:Thrombopoietin