Metabolic features of the adaptive effect of delta-sleep inducing peptide and piracetam under hyperoxic conditions.
Adaptive effects of delta-sleep inducing peptide (DSIP, 12 microgram/100 g body weight, single intraperitoneal injection) and piracetam (3 mg/100 g body weight, daily intraperitoneal injection for 3 days) are manifested via differential changes in neurotransmitter amino acids (GABA, glutamate, aspartate), modulation of transport ATPase activity, and decreased accumulation of lipid peroxidation products (conjugated dienes, malonic dialdehyde, Schiff bases) in various fractions of neuronal membranes (myelin, synaptic and mitochondrial membranes) in the sensomotor cortex of rat brain. Under hyperbaric oxygenation (0.3 MPa for 2 h), the combination of DSIP and piracetam enhanced the protective effect of each compound.
Lysenko
A V
AV
Neurocybernetics Institute, Rostov State University, Rostov-on-Don, 344090, Russia. mam@krink.rnd.runnet.ru.
Alperovich
D V
DV
Uskova
N I
NI
Mendzheritsky
A M
AM
D000222:Adaptation, Physiological; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D018496:Hyperoxia; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D009186:Myelin Sheath / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003701:Delta Sleep-Inducing Peptide; D010100:Oxygen; D010889:Piracetam