[Diffusion images on brain MRI in Creutzfeldt-Jakob disease].
We report a 72-year-old man with Creutzfeldt-Jakob disease. He showed a progressive dementia, myoclonus, and other neurological symptoms. DNA analysis showed a normal variation of prion gene (codon 129, Met/Met: codon 219, Glu/Glu). He had periodic synchronous discharge on electroencephalogram and brain atrophy on CT scan and MRI. Diffusion images on his brain MRI revealed a marked increase in signal intensity in the caudate nuclei, putamen, and cerebral cortices. These changes may represent spongy changes of the brain and seem to be a feature of brain MRI in Creutzfeldt-Jakob disease.
Nagaoka
U
U
Third Department of Internal Medicine, Yamagata University School of Medicine, Japan.
Kurita
K
K
Hosoya
T
T
Kitamoto
T
T
Kato
T
T
D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D011328:Prions / Q000235:genetics
D011328:Prions