DNA repair: Polymerases for passing lesions.
Replicative DNA polymerases generally cannot pass lesions in the template strand. Now there is accumulating evidence for the widespread existence of a separate class of DNA polymerases that can carry out translesion synthesis in both mutagenic and error-free ways.
MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, East Sussex, BN1 9RR, UK.
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Bridges
D001426:Bacterial Proteins / Q000302:isolation & purification / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D029968:Escherichia coli Proteins; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009154:Mutation; D029701:Saccharomyces cerevisiae Proteins; D014983:Xeroderma Pigmentosum / Q000235:genetics; D000094769:DNA Polymerase iota; D000099270:Y-Family DNA Polymerases
D001426:Bacterial Proteins; D004247:DNA; D004259:DNA-Directed DNA Polymerase; D029968:Escherichia coli Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D000094769:DNA Polymerase iota; C094399:DinB protein, E coli; C078202:UmuC protein, E coli; C092602:REV3 protein, S cerevisiae; C112338:Rad30 protein; D000099270:Y-Family DNA Polymerases; C000722070:POLI protein, human