Protective effect of exogenous coenzyme Q in rats subjected to partial hepatic ischemia and reperfusion.
In a surgical model of liver ischemia lipid peroxidation occurs, as shown by increase of lipid peroxidation end products, endogenous CoQ9 is oxidized and mitochondrial respiration is lowered; however, pre-treatment of the rats by i.p. injection of CoQ10 for 14 days normalizes the above parameters, presumably by way of the observed high extent of reduction of the incorporated quinone; moreover, liver homogenates of the CoQ10-treated rats are more resistant than those of non-treated rats to oxidative stress induced by an azido free radical initiator. This preliminary study suggests that CoQ10 pre-treatment can be of beneficial effect against oxidative damage during liver surgery transplantation.
Department of Biochemistry G. Moruzzi, University of Bologna, Italy.
M L
ML
Genova
E
E
Bonacorsi
M
M
D'Aurelio
G
G
Formiggini
B
B
Nardo
S
S
Cuccomarino
P
P
Turi
M M
MM
Pich
G
G
Lenaz
C
C
Bovina
D000578:Amidines / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D007511:Ischemia / Q000503:physiopathology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D016877:Oxidants / Q000494:pharmacology; D051381:Rats; D015424:Reperfusion; D015427:Reperfusion Injury / Q000517:prevention & control*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D000578:Amidines; D000975:Antioxidants; D016877:Oxidants; D014801:Vitamin A; D014451:Ubiquinone; D014810:Vitamin E; C046728:2,2'-azobis(2-amidinopropane)