[The functional activity of the ATP-dependent K+ channels of normal pancreatic beta cells and in pathology].
The paper deals with the analysis of the status of ATP-dependent K+ channels of pancreatic beta cell functional by attenuated under the effect of streptozotocin and simultaneous assessment of their reaction to sulfonylamide agents glybenclamide, glipizil and glyclazid. Highly specific response of the tested ionic channels showed under the effect of both glucose and sulfonylurea agents. Analysis of the time course of electrophysiological processes coursing in them, showed appreciable changes in the time of the channel closing, which led to deceleration of insulin secretin starting from the moment of exposure to glucose or sulfonylurea agents till exocytosis of insulin quantum. Glybenclamide proved to be the most active of the tested agents as regards their secretogenic properties.
Endocrinological Research Centre, Russia Academy of Medical Sciences.
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Babichev
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004594:Electrophysiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D013311:Streptozocin / Q000494:pharmacology; D013424:Sulfanilamides / Q000494:pharmacology; D013997:Time Factors
D007328:Insulin; D015221:Potassium Channels; D013424:Sulfanilamides; D013311:Streptozocin; D000255:Adenosine Triphosphate
Funktsional'naia aktivnost' AFT-zavisimykh K+ kanalov beta-kletok podzhelludochnoĭ zhelezy v norme i pri patologii.