[Three week stay at a height of 3700-4200 m. causes mild pulmonary hypertension in healthy men].
High altitude hypoxia leads to development of hypoxic pulmonary hypertension. We studied 27 healthy caucasian subjects aged 24 to 59 years, mean 41.6 +/- 9 y, working on 4 week shifts at the Kumtor gold mines at the altitude of 3700-4200 m. Pulmonary circulation was studied twice by Echo-Doppler using Toshiba SSD-160. The first investigation was performed at the level of 730 m at the end of 4 week holiday spent in the lowland, the second investigation on the 23rd day at altitude. Pulmonary artery acceleration time decreased from 131 +/- 14 ms to 105 +/- 14 ms (p < 0.001). Calculated pulmonary arterial mean pressure increased from 15.1 +/- 2 to 25.4 +/- 8 mmHg (p < 0.001). Right ventricular preejection period increased from 93 +/- 14 to 102 +/- 19 ms (p < 0.05). Other echo variable did not change. We conclude that healthy subjects submitted to 3 week exposure to high altitude hypoxia (oxygen pressure in the inspired air 82-88 mmHg), developed mild pulmonary hypertension, regressing after recovery at the lowland.
Pałasiewicz
G
G
Kliniki Chorób Płuc, Instytutu Gruźlicy i Chorób Płuc, Warszawa.
Usupbaeva
D A
DA
Le Roux
H
H
Sarybayev
A S
AS
Pływaczewski
R
R
Mirrakhimov
M M
MM
Zieliński
J
J
D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000000981:diagnostic imaging*; D015150:Echocardiography, Doppler; D004784:Environmental Monitoring; D006046:Gold; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D008906:Mining; D016273:Occupational Exposure; D011652:Pulmonary Circulation; D012016:Reference Values
D006046:Gold
Trzytygodniowy pobyt na wysokości 3700-4200 m. wywołuje łagodne nadciśnienie płucne u zdrowych mezczyzn.