Long-term persistence of immunoglobulin A (IgA) and IgM antibodies against human cytomegalovirus in solid-organ transplant recipients.
The retrospective analysis of 494 solid-organ transplant recipients revealed that during the follow-up period (mean duration, 3.2 years) 184 (88%) of 209 anti-human cytomegalovirus (HCMV) immunoglobulin A (IgA)-positive patients remained IgA positive, as did 128 (74.85%) of 171 anti-HCMV IgM-positive patients. We conclude that anti-HCMV IgA and IgM testing for management of clinically relevant HCMV infections in solid-organ transplant recipients is dispensable.
Institute of Medical Microbiology, Clinical Virology, University of Muenster, Muenster, Germany. eingb@uni-muenster.de
B R
BR
Eing
H G
HG
Baumeister
J E
JE
Kuehn
G
G
May
D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D015331:Cohort Studies; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016377:Organ Transplantation / Q000502:physiology*; D010750:Phosphoproteins / Q000097:blood; D013997:Time Factors; D014181:Transplantation Immunology / Q000276:immunology; D014763:Viral Matrix Proteins / Q000097:blood
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D004279:DNA, Viral; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C049937:anti-IgA; C044203:anti-IgM; C065418:cytomegalovirus matrix protein 65kDa