IgM/IgA nephropathy in callitrichids: antigen studies.
Renal tissues of callitrichids with IgM nephropathy were immunohistochemically examined for the participation of IgA in pathogenesis. In 58 histopathologically nephropathy-positive kidneys, IgM predominated in 20 cases and IgA in 7 cases, and in 31 cases both immunoglobulins were rated to be approximately equally involved. The disease, therefore, might be described as IgM/IgA nephropathy. The renal tissues and sera were also tested for nutritional antigens or antinutritional antigen antibodies, using immunohistochemistry and Western blots (tissues) and enzyme-linked immunosorbent assay (sera). Evidences of nutritional antigens in the renal tissues were inconclusive, although circulating IgG class antibodies against cereals, milk, and egg proteins were present in quite a number of sera. Particular consideration was paid to IgA-antigliadin antibodies, which were statistically significantly associated with nephropathy as were IgA rheumatoid factors. The findings are discussed in relation to human IgA and IgM nephropathies.
German Primate Center, Göttingen, Germany.
M
M
Brack
C
C
Schroeder
M
M
Fooke
W
W
Schlumberger
D000818:Animals; D000941:Antigens / Q000276:immunology; D002143:Callitrichinae / Q000276:immunology*; D005502:Food; D005903:Gliadin / Q000097:blood / Q000276:immunology; D005920:Glomerular Mesangium / Q000276:immunology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008992:Monkey Diseases / Q000473:pathology*; D012217:Rheumatoid Factor / Q000097:blood / Q000276:immunology
D000941:Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005903:Gliadin; D012217:Rheumatoid Factor