Glioblastoma multiforme following prophylactic cranial irradiation and intrathecal methotrexate in a child with acute lymphoblastic leukaemia : a case report.
A 12 year old boy with acute lymphoblastic leukaemia had received prophylactic cranial irradiation (2000 cGy/15 days) and intrathecal methotrexate. Six years later he was diagnosed to have glioblastoma in left temporoparietal region. There is a strong possibility that the glioma may have been radiation and/or chemotherapy induced.
Departments of Neurosurgery and Neuropathology, K.E.M. Hospital, Mumbai, 12, India.
D P
DP
Muzumdar
K
K
Desai
A
A
Goel
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002648:Child; D005909:Glioblastoma / Q000209:etiology*; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate