Antioxidant actions of plant foods: use of oxidative DNA damage as a tool for studying antioxidant efficacy.
Plant-food-derived antioxidants and active principles such as flavonoids, hydroxycinnamates (ferulic acid, chlorogenic acids, vanillin etc.), beta-carotene and other carotenoids, vitamin E, vitamin C, or rosemary, sage, tea and numerous extracts are increasingly proposed as important dietary antioxidant factors. In this endeavor, assays involving oxidative DNA damage for characterizing the potential antioxidant actions are suggested as in vitro screens of antioxidant efficacy. The critical question is the bioavailability of the plant-derived antioxidants.
Faculty of Pharmaceutical Sciences, University of São Paulo-Ribeirão Preto, Brazil. oiaruoma@fcfrp.usp.br
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D000975:Antioxidants / Q000032:analysis / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D018736:DNA Adducts / Q000032:analysis / Q000235:genetics; D004249:DNA Damage; D009566:Nitrates / Q000037:antagonists & inhibitors / Q000378:metabolism; D018384:Oxidative Stress; D010618:Phenanthrolines / Q000378:metabolism; D010945:Plants, Edible / Q000737:chemistry* / Q000378:metabolism
D000975:Antioxidants; D018736:DNA Adducts; D009566:Nitrates; D010618:Phenanthrolines; C039642:peroxynitric acid; D003300:Copper