Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >/=76 yr old.
Muscle atrophy (sarcopenia) in the elderly is associated with a reduced rate of muscle protein synthesis. The purpose of this study was to determine if weight-lifting exercise increases the rate of muscle protein synthesis in physically frail 76- to 92-yr-old women and men. Eight women and 4 men with mild to moderate physical frailty were enrolled in a 3-mo physical therapy program that was followed by 3 mo of supervised weight-lifting exercise. Supervised weight-lifting exercise was performed 3 days/wk at 65-100% of initial 1-repetition maximum on five upper and three lower body exercises. Compared with before resistance training, the in vivo incorporation rate of [(13)C]leucine into vastus lateralis muscle protein was increased after resistance training in women and men (P < 0.01), although it was unchanged in five 82 +/- 2-yr-old control subjects studied two times in 3 mo. Maximum voluntary knee extensor muscle torque production increased in the supervised resistance exercise group. These findings suggest that muscle contractile protein synthetic pathways in physically frail 76- to 92-yr-old women and men respond and adapt to the increased contractile activity associated with progressive resistance exercise training.
Yarasheski
K E
KE
Claude D. Pepper Older American's Independence Center, Divisions of Geriatrics and Gerontology and Metabolism, Endocrinology, and Diabetes, Washington University Medical Center, St. Louis, Missouri 63110, USA. key@imgate.wustl.edu
Pak-Loduca
J
J
Hasten
D L
DL
Obert
K A
KA
Brown
M B
MB
Sinacore
D R
DR
D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology; D003404:Creatinine / Q000652:urine; D005260:Female; D016330:Frail Elderly; D006801:Humans; D007866:Leg; D008297:Male; D008762:Methylhistidines / Q000652:urine; D009124:Muscle Proteins / Q000096:biosynthesis*; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D009929:Organ Size / Q000502:physiology; D010806:Physical Education and Training; D012727:Sex Characteristics; D014891:Weight Lifting
D008762:Methylhistidines; D009124:Muscle Proteins; D003404:Creatinine; C028118:3-methylhistidine