A new protection/activation strategy for the synthesis of naturally occurring and non-natural alpha-N-alkylamino acids.
A new method for the preparation of N-methylamino acids and some of their derivatives starting from hexafluoroacetone protected amino acids is described. The new concept results in saving of steps compared to conventional protection/activation techniques. Protection and deprotection proceed without recemization.
Institut für Organische Chemie, Universität Leipzig, Federal Republic of Germany. burger@organik.orgchem.uni-leipzig.de
K
K
Burger
H
H
Schedel
J
J
Spengler
D000096:Acetone / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000603:Amino Acids, Sulfur / Q000737:chemistry; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry; D018698:Glutamic Acid / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated
D000096:Acetone; D000596:Amino Acids; D000603:Amino Acids, Sulfur; D005466:Fluorocarbons; D018698:Glutamic Acid; D010758:Phosphorus; C017366:hexafluoroacetone; D006845:Hydrocarbons, Fluorinated