Transplantation without immunosuppression: what the future may hold.
Research in noncompliant allograft recipients and in a murine model has led us to hypothesize that it may be possible to exploit the phenomenon of linked antigen recognition in human organ transplantation. If this approach proves successful, it may ultimately allow transplant recipients to avoid taking immunosuppressive drugs long-term.
Division of Transplantation, Ohio State University, USA.
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D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D051379:Mice; D014180:Transplantation / Q000379:methods*; D019172:Transplantation Conditioning / Q000379:methods*; D014181:Transplantation Immunology / Q000502:physiology*