Stereoselective synthesis of (+/-)-epibatidine analog:(+/-)-2beta-(2-chloro-5-pyridinyl)-8-azabicyclo[3.2.1] octane.
Stereoselective synthesis of (+/-)-epibatidine analog 2, which contains the 8-azabicyclo[3.2.1]octane ring system, was achieved by using palladium-catalyzed Heck-type coupling reaction from 3.
Kim
Y H
YH
College of Pharmacy, SungKyunKwan University, Suwon, Korea.
Won
D Y
DY
Oh
C Y
CY
Woo
N T
NT
Park
Y H
YH
Jeong
J H
JH
Ham
W H
WH
D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D018722:Nicotinic Agonists / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
C122104:2-(2-chloro-5-pyridinyl)-8-azabicyclo(3.2.1)octane; D018712:Analgesics, Non-Narcotic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018722:Nicotinic Agonists; D011725:Pyridines; D010165:Palladium; C082748:epibatidine