The maturing kidney: development and susceptibility.
Kidney morphogenesis is accomplished by the coordinated interaction of molecular signals that culminate in the production of an organ that is architecturally and functionally ready for extrauterine, free life. In humans, nephrogenesis is completed before birth. However the kidney continues to mature both from a functional and anatomical point of view. Throughout its development, the kidney is susceptible to a variety of injurious agents. This brief review considers the basic mechanisms of kidney organogenesis and functional maturation. To illustrate some concepts, the renal alterations caused by interference with a normal regulatory system, the renin-angiotensin system is discussed.
University of Virginia School of Medicine, Charlottesville 22908, USA. rg@hscmail.mcc.virginia.edu
R A
RA
Gomez
M L
ML
Sequeira Lopez
L
L
Fernandez
D R
DR
Cherñavvsky
V F
VF
Norwood
D000818:Animals; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000196:embryology* / Q000254:growth & development* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology*