[Survey of the sensitivities of clinical isolates to antibacterial agents (annual report)].
Research groups were formed in 21 institutions nationwide to investigate carbapenem resistance. The activities of various antibacterial agents, principally carbapenems, were tested against clinical isolates collected from these institutions. The broth microdilution method was used to determine the minimum inhibitory concentrations (MIC) of 17 antibacterial agents for 1,241 strains of 11 bacterial species isolated at all institutions between October and December 1996. The results were as follows: Carbapenems exhibited strong antibacterial activities against MSSA and Streptococcus pneumoniae and showed low activities against MRSA. Their activities against Enterococcus faecalis were comparable to that of ampicillin and piperacillin. The carbapenems showed high activities against Haemophilis influenzae, Escherichia coli, Klebsiella pneumoniae. Enterobacter cloacae. Serratia marcescens and Bacteroides fragilis group. Their activities were greater than that exhibited by other beta-lactam antibacterial agents, but some resistant strains of Serratia marcescens were detected. The antibacterial activity of carbapenems against Pseudomonas aeruginosa was comparable to that of CAZ, and there were some resistant strains.
Department of Clinical Pathology, Juntendo University, School of Medicine.
J
J
Igari
T
T
Shibano
S
S
Satou
M
M
Inoue
I
I
Kobayashi
A
A
Takahashi
S
S
Yomoda
T
T
Nishino
T
T
Oguri
N
N
Watanabe
N
N
Uehara
K
K
Kumasaka
H
H
Yoshida
Y
Y
Imafuku
Y
Y
Kobayasi
J
J
Okada
K
K
Tokuda
Y
Y
Hirata
N
N
Nakasaki
T
T
Hongo
R
R
Kawaguchi
Y
Y
Ohtaki
T
T
Sasaki
N
N
Matsumoto
H
H
Saeki
D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests / Q000379:methods; D013845:Thienamycins / Q000494:pharmacology; D013997:Time Factors
D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem; C039536:panipenem; C065257:biapenem