Kainic acid into the parapyramidal region protects against gastric injury by ethanol.
Neurons in the parapyramidal region of the ventral medulla project to the dorsal vagal complex and intermediolateral column. Kainic acid (0.5-5.0 ng) microinjected unilaterally into the parapyramidal region reduced 45% ethanol-induced gastric lesions by 50-60% in urethane anesthetized rats. Microinjections at sites nearby, but outside of the parapyramidal region, had no effect. These results provide the first evidence that the activation of parapyramidal region neurons influences gastric function and suggests a possible role of this ventral medulla region in gastric regulation.
West Los Angeles VA Medical Center, Department of Medicine, UCLA, CA 90073, USA.
H
H
Yang
K
K
Kawakubo
Y
Y
Taché
D000704:Analysis of Variance; D000818:Animals; D000431:Ethanol; D007608:Kainic Acid / Q000627:therapeutic use*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D020011:Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects / Q000502:physiology; D013272:Stomach Diseases / Q000139:chemically induced / Q000517:prevention & control*
D020011:Protective Agents; D000431:Ethanol; D007608:Kainic Acid