Recurrent thrombo-embolic episodes: the association of cholangiocarcinoma with antiphospholipid syndrome.
Antiphospholipid syndrome is a disorder of recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies. It was first described in a group of patients with systemic lupus erythematosus but has since been associated with a wide range of conditions, including other autoimmune disorders and malignancy. It can also occur in isolation, the so-called primary antiphospholipid syndrome. We describe an elderly woman with the antiphospholipid syndrome thought to be associated with a cholangiocarcinoma.
Department of Medicine for the Elderly, St Helier NHS Trust, Carshalton, Surrey, UK.
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Samadian
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Estcourt
D000368:Aged; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001650:Bile Duct Neoplasms / Q000150:complications*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D012008:Recurrence; D020246:Venous Thrombosis / Q000150:complications*