C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction.
C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.
Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor 48109-1078, USA. wgiannob@umich.edu
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D016301:Alveolar Bone Loss / Q000175:diagnosis*; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001862:Bone Resorption / Q000175:diagnosis*; D003094:Collagen / Q000032:analysis*; D024042:Collagen Type I; D006801:Humans; D010003:Osteoarthritis / Q000175:diagnosis; D010024:Osteoporosis / Q000175:diagnosis; D010455:Peptides / Q000032:analysis*; D010510:Periodontal Diseases / Q000175:diagnosis*
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C015484:pyridinoline; D003094:Collagen