An animal model of chronic cyclosporine nephrotoxicity.
The development of a reproducible animal model that mimics CSA nephropathy in man has allowed the examination of the several proposed mechanisms of toxicity. While the precise mechanism remains to be defined, important clues have been provided and creative techniques for minimizing the adverse effects of this very valuable adjunct to transplant success have been identified.
Porter
G A
GA
Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201, USA. porterg@ohsu.edu
Andoh
T F
TF
Bennett
W M
WM
D000818:Animals; D002908:Chronic Disease; D016572:Cyclosporine / Q000633:toxicity*; D004195:Disease Models, Animal; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine