Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report.
BACKGROUND
Of ovarian stromal tumors containing Leydig cells, nonhilar, pure stromal-Leydig cell tumor is rare.


METHODS
An obese, diabetic, borderline hypertensive 41-year-old woman with a five-year history of oligomenorrhea and amenorrhea presented with complaints of masculinization. Physical examination revealed hirsutism and an enlarged clitoris. The only abnormal serum marker was elevated testosterone. At laparotomy both ovaries were enlarged and suspected to have bilateral stromal hyperthecosis. Histology revealed stromal hyperplasia along with a 1.5-cm, testosterone-producing pure stromal-Leydig cell tumor of the right ovary.


CONCLUSIONS
Bilateral ovarian enlargement secondary to stromal hyperplasia in patients with masculinizing signs can conceal a small, unilateral pure stromal-Leydig cell tumor.
Department of Pathology, State University of New York Health Science Center at Syracuse 13210, USA.
A
A
Oler
M
M
Singh
S H
SH
Ural
D000328:Adult; D000568:Amenorrhea / Q000150:complications; D001706:Biopsy; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007984:Leydig Cell Tumor / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009765:Obesity / Q000150:complications; D009839:Oligomenorrhea / Q000150:complications; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D010053:Ovary / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology; D013739:Testosterone / Q000097:blood
D013739:Testosterone