Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts.
Recent advances in microbial steroid hydroxylation are covered, including new biocatalysts and substrate groups and new methodologies such as the use of low-water systems, immobilised biocatalysts, genetically constructed biocatalysts and enzyme mimics. Mechanistic factors that control the regiochemistry and stereochemistry of steroid hydroxylation are also discussed.
Holland
H L
HL
Department of Chemistry, Brock University, St. Catharines, ON, Canada. holland@chemiris.labs.brocku.ca
D002384:Catalysis; D006900:Hydroxylation; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
D013256:Steroids; D013250:Steroid Hydroxylases