Diet modulates Th-1 and Th-2 cytokine production in the peripheral blood of lupus-prone mice.
Calorie restriction or fish oil extends life span. To investigate the potential mechanism(s) involved, young (4-month) and old (9-month) NZB x NZW(F1) mice were fed 5% (w/w) corn oil (CA) or fish oil (FA) ad libitum or 40% restricted (CR and FR, respectively). Peripheral blood T-lymphocytes were analyzed for Th-1 (IL-2, IFN-gamma) and Th-2 (IL-5, IL-10) production. CR and FA partially blunted while FR completely abolished the decline in aged CD4+ T lymphocytes. In contrast, both CR and FR abolished the decline in CD8+ T lymphocytes with age, while FA had no effect. In aged mice, both CR and FR blunted the increase in Th-1 (IL-2, IFN-gamma) cytokine production, while FA was only partially effective. Only FR completely blunted the age-related increase in Th-2 (IL-5, IL-10) cytokine production. These data suggest that FR delays the onset of autoimmune kidney disease by suppressing both Th-1 and Th-2 cytokine production.
Jolly
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Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7874, USA.
Fernandes
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D000375:Aging / Q000276:immunology; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003314:Corn Oil / Q000008:administration & dosage; D016207:Cytokines / Q000096:biosynthesis*; D004032:Diet; D004195:Disease Models, Animal; D002149:Energy Intake; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008814:Mice, Inbred NZB; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines; D005395:Fish Oils; D003314:Corn Oil