Fibroblast growth factor signaling regulates growth and morphogenesis at multiple steps during brain development.
The fibroblast growth factor (FGF) family comprises several members with distinct patterns of expression in the developing central nervous system. FGFs regulate the early specification and the subsequent growth of central nervous system regions. These different actions require the coordinated activation of distinct sets of target genes by FGFs at the appropriate stage of development. The role of FGF2 in the growth and morphogenesis of the cerebral cortex is reviewed in detail. The cellular and molecular mechanisms that underlie the action of FGF2 on cortical development are discussed.
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
F M
FM
Vaccarino
M L
ML
Schwartz
R
R
Raballo
J
J
Rhee
R
R
Lyn-Cook
D000818:Animals; D001921:Brain / Q000196:embryology*; D002454:Cell Differentiation; D019070:Cell Lineage; D002490:Central Nervous System / Q000196:embryology; D002540:Cerebral Cortex / Q000166:cytology; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009024:Morphogenesis; D015398:Signal Transduction
D005346:Fibroblast Growth Factors