Effect of bacterial antigen lysate on IgG and IgA levels in children with recurrent infections and hypogammaglobulinemia.
To evaluate the effect of bacterial antigen lysate on serum immunoglobulin (Ig) levels, we studied 14 children with recurrent infections and hypogammaglobulinemia (IgG and IgA levels below 2 standard deviations for age). Patients were treated for a 60-90 day period with OM-85 BV and reevaluated both clinically and by measuring serum Ig levels at the end of follow-up. The control group consisted of 10 children with recurrent infections who received a placebo. Serum Ig levels were also compared with the reference values for age. The Wilcoxon and Mann-Whitney tests were used for statistical analysis. In the study group, IgG (pretreatment: 707 mg/dl; post-treatment: 1,022 mg/dl; p < 0.004) and IgA levels (pretreatment: 41 mg/dl; post-treatment: 83 mg/dl; p < 0.018) increased significantly. Furthermore, 13/14 children reached normal IgG levels, and 12/14 children reached normal age levels for serum IgA. Similarly, when comparing the pre- and post-treatment levels in the study group with the levels in the control group, they were significant for IgG (p < 0.002) as well as IgA levels (p < 0.04). The overall clinical response was favorable in all patients in the treated group. These results suggest an immunostimulant effect of OM-85 BV, both improving Ig levels and reducing recurrent infections.
Department of Pediatrics, School of Medicine, University of Chile, Hospital Exequiel Gonzalez Cortes, Santiago, Chile.
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Quezada
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Maggi
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Pérez
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Rodríguez
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000361:Agammaglobulinemia / Q000628:therapy*; D000942:Antigens, Bacterial / Q000494:pharmacology*; D001419:Bacteria; D002457:Cell Extracts; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male; D012141:Respiratory Tract Infections / Q000097:blood; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D002457:Cell Extracts; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007369:Interferon Inducers; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates