Paraneoplastic cicatricial pemphigoid.
We report a 39-year-old woman with antiepiligrin cicatricial pemphigoid (CP) in association with non-small cell carcinoma of the lung. At presentation, mucosal lesions showed minimal response to combined systemic immunosuppressive agents. Following the diagnosis of non-small cell lung carcinoma and subsequent treatment with gemcitabine (a second-line chemotherapeutic agent), a significant reduction in both tumour mass and mucosal blistering was observed. Metastatic disease was subsequently associated with recurrent oral erosions. We believe this patient represents the first reported case of paraneoplastic CP.
St John's Institute of Dermatology, St Thomas' Hospital (GKT), London SE1 7EH, UK. j.setterfield2umds.ac.uk
J
J
Setterfield
P J
PJ
Shirlaw
Z
Z
Lazarova
B M
BM
Bryant
B S
BS
Bhogal
K
K
Harman
S J
SJ
Challacombe
M M
MM
Black
D000328:Adult; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D016253:Microscopy, Immunoelectron; D010257:Paraneoplastic Syndromes / Q000276:immunology / Q000473:pathology*; D010390:Pemphigoid, Benign Mucous Membrane / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000276:immunology / Q000473:pathology*; D000097794:Kalinin
D015815:Cell Adhesion Molecules; D003176:Complement C3; D007074:Immunoglobulin G; D000097794:Kalinin