Relationship of mismatch negativity to background EEG and morphological findings in schizophrenia.
The present study assessed relationships of mismatch negativity (MMN) of schizophrenics with other markers; quantitative EEG (QEEG), computed tomography (CT) and psychopathological ratings. Patients were divided into two groups before treatment; group A consisted of patients with greater MMN amplitudes while patients with lower ones were assigned to group B. In QEEG, group A showed no significant differences compared to controls, except for fast beta in the frontal region. The finding of well-preserved QEEG in group A indicates their function is less distorted than in group B, who showed greater powers in slow waves, slow alpha and fast beta bands. The greater slow-wave power of group B may be related to the cognitive impairment reflected by attenuated MMN, which corresponded to greater dilation in lateral ventricles and Sylvian fissures of group B on CT. Conclusively, MMN have crucial relationships to other biological markers representing the psychopathology of schizophrenia.
Juntendo University School of Medicine, Department of Psychiatry, Koshigaya, Saitama, Japan. kirino@biac.duke.edu
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D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed