Recruitment of proteins to modulate protein-protein interactions.
The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand with its protein target has been reported recently. This approach represents a general method for modulating protein-protein interactions and may find many applications in both biology and medicine.
Center for Cancer Research, Departments of Biology and Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. junliu@mit.edu
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D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism / Q000502:physiology*; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D008565:Membrane Proteins; D011506:Proteins