Prevention and treatment of osteoporosis in primary biliary cirrhosis.
Osteoporosis is not a feature unique to primary biliary cirrhosis (PBC) but is also found in other categories of liver disease. The principles developed for monitoring and treating postmenopausal osteoporosis can also be followed for patients with PBC. Monitoring of dietary intake of calcium and vitamin D serum levels is essential, and the threshold for initiating supplementation should be low. Bisphosphonates can be considered the most rational choice when specific therapy is required.
Department of Gastroenterology & Hepatology, Medicine III, Erasmus University Hospital Rotterdam, The Netherlands.
F P
FP
Vleggaar
H R
HR
van Buuren
F H
FH
Wolfhagen
S W
SW
Schalm
H A
HA
Pols
D001842:Bone and Bones / Q000187:drug effects; D002908:Chronic Disease; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000503:physiopathology; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy*
D004164:Diphosphonates; D005938:Glucocorticoids