Invasive group B streptococcal disease in nonpregnant adults.
Forty episodes of invasive group B streptococcal infections in nonpregnant adults at Chris Hani Baragwanath Hospital, Soweto, South Africa, were retrospectively reviewed. The mean age of the patients was 45.6 years. Twenty (50%) patients were bacteraemic. Common predisposing conditions included diabetes mellitus (27.5%), trauma (25%), and HIV infection (12.5%). Soft tissue abscesses and pneumonia accounted for 70% of the presentations. Ten (25%) patients had acquired the infection nosocomially. Death occurred in 14 (35%) patients and was significantly associated with bacteraemia (P = 0.0009) and pneumonia (P = 0.0012). Trauma is an important predisposing condition, and HIV infection may have played a role in the setting described; both factors probably accounted for the relatively young age of the patients.
Perovic
O
O
Department of Clinical Microbiology and Infectious Diseases, Chris Hani Baragwanath Hospital and University of the Witwatersrand, Johannesburg, South Africa.
Crewe-Brown
H H
HH
Khoosal
M
M
Karstaedt
A S
AS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000401:mortality / Q000503:physiopathology; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D013290:Streptococcal Infections / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*; D013292:Streptococcus agalactiae; D014947:Wounds and Injuries / Q000150:complications