The antibacterial activity of plaunotol against Staphylococcus aureus isolated from the skin of patients with atopic dermatitis.
Plaunotol was tested for possible antibacterial activity against twenty strains of methicillin-resistant Staphylococcus aureus (MRSA) and fourteen strains of methicillin-sensitive S. aureus (MSSA) which had been isolated from the skin of patients with atopic dermatitis under growth-promoting conditions. Plaunotol was effective against all strains tested. The dose of plaunotol for 50% inhibition of growth (ID50) ranged from 2.5 to 16 micrograms/ml for strains of MRSA and from 2.5 to 7.0 micrograms/ml for those of MSSA. These results suggest that plaunotol may be useful in the prevention of infection by MRSA and in skin care for patients with atopic dermatitis.
Department of Microbiology, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Y
Y
Matsumoto
H
H
Hamashima
K
K
Masuda
K
K
Shiojima
M
M
Sasatsu
T
T
Arai
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003876:Dermatitis, Atopic / Q000382:microbiology*; D004224:Diterpenes; D004352:Drug Resistance, Microbial; D005233:Fatty Alcohols / Q000494:pharmacology*; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D012867:Skin / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D005233:Fatty Alcohols; C047686:plaunotol; D008712:Methicillin