[The technology for manufacturing antiparasitic preparations. 9. The new preparation tizanox and an evaluation of its anti-Hymenolepis activity].
The paper describes a procedure for manufacturing the new anthelminthic Tizanox. It shows it necessary to administer a larger dose of the drug than that of azinox (praziquantel) to treat experimental hymenolepiasis. However, the lower toxicity of Tizanox enhances its chemotherapeutical index.
F S
FS
Mikhaĭlitsyn
N L
NL
Sergovskaia
N A
NA
Uvarova
B V
BV
Lopatin
G A
GA
Gitsu
B A
BA
Astaf'ev
M N
MN
Lebedeva
N D
ND
Lychko
D000818:Animals; D000923:Anticestodal Agents / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006925:Hymenolepiasis / Q000188:drug therapy*; D007546:Isoquinolines / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D011223:Praziquantel / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity; D013055:Spectrophotometry, Infrared / Q000706:statistics & numerical data; D013829:Thiadiazines / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity
D000923:Anticestodal Agents; D007546:Isoquinolines; D013829:Thiadiazines; C078071:azinox; C078109:tizanox; D011223:Praziquantel
Tekhnologiia proizvodstva protivoparazitarnykh preparatov. 9. Novyĭ preparat tizanoks i otsenka ego protivogimenolepidoznoĭ aktivnosti.