The course of the remnant kidney model in mice.
The remnant kidney model was produced in mice by unilateral nephrectomy and partial infarction of the remaining kidney. Control mice underwent laparotomy only. The mice were studied for up to 44 weeks. No quantitative differences were noted in systolic arterial pressure, proteinuria, or histopathology between control mice and those with a remnant kidney. Glomerular enlargement occurred in the remnant kidney.
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Department of Medicine, School of Medicine, University of Minnesota, Minneapolis 55455, USA.
Hostetter
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D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D007238:Infarction / Q000473:pathology / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008026:Ligation; D051379:Mice; D008810:Mice, Inbred C57BL; D009392:Nephrectomy; D011507:Proteinuria / Q000209:etiology; D012077:Renal Artery; D012079:Renal Circulation / Q000502:physiology; D013599:Systole