A study to determine if basic fibroblast growth factor (bFGF) reduces myocardial infarct size in acute coronary arterial occlusion.
We investigated the angiogenic and myocardial salvage effects of bFGF. Twelve beagles with ligated left anterior descending coronary arteries were divided into two groups: a FGF group administered bFGF intravenously, and a Control group, after CAG immediately post-ligation. One week post-ligation, CAG was repeated. The heart was sliced along the short axis. For each section, the fluorescein Na staining deficit area (DA) and ratio of DA to total area (DAR), TTC staining of the infarct area (IA) and ratio of IA to total area (IAR), and Masson trichrome staining of the fibrosed area (MA) and ratio of MA to total area (MAR), were calculated. The increase in the number of collateral vessels, seen on CAG from post-ligation to 1 week later, was significantly greater in the FGF group. No significant differences in IAR or MAR were seen between the groups. However, DAR and DA/IA were significantly less in the FGF group. In conclusion, bFGF had no effect on infarct size, but stimulated the growth of collateral vessels and improved coronary blood flow in IA.
Second Department of Internal Medicine, Tokyo Medical University, Japan.
A
A
Sasame
H
H
Nakajima
K
K
Tamura
M
M
Miyagi
H
H
Rakue
M
M
Usui
T
T
Katoh
Y
Y
Naitoh
C
C
Ibukiyama
D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects*; D015986:Confounding Factors, Epidemiologic; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control*; D011897:Random Allocation
D016222:Fibroblast Growth Factor 2