Cerebellar papillary meningioma in a 3-year-old boy: the usefulness of electron microscopy for diagnosis.
We report one case of papillary meningioma located in the posterior fossa in a 3-year-old boy. Despite a gross total resection, a major recurrence occurred 6 months later that was operated on. Eight months later, another recurrence was observed with intracranial metastases and dissemination throughout the cerebrospinal fluid. The tumor had a papillary architecture more obvious in the recurrence. Areas of necrosis were numerous. Tumor cells had large clear atypical nuclei. Many mitotic figures were seen and Ki-67 labeling index was high. The tumor cells were immunoreactive for vimentin and polysialylated neural cell adhesion molecule only, ruling out a diagnosis of ependymoma or medulloblastoma. Diagnosis of meningioma was done by electron microscopy, which showed interdigitating cytoplasmic processes and cell junctions. Cytogenetic study revealed unusual karyotypic abnormalities.
Department of Pathology and Neuropathology, CHU Timone, Marseille, France.
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C
Bouvier
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H
Zattara-Canoni
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L
Daniel
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JC
Gentet
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G
Lena
D
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Figarella-Branger
D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003388:Cranial Fossa, Posterior / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D019394:Ki-67 Antigen; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; D014746:Vimentin; C103469:polysialyl neural cell adhesion molecule