[Defect of preferential repair of gamma-ray-induced single-strand breaks in transcribed DNA in ataxia-telangiectasia cells].
Transcriptionally activity-dependent heterogeneity of gamma-induced DNA single-strand break repair in ataxia-telangiectasia cells has been investigated. It is found that in AT cells no increased induction of damage in the c-myc gene compares with normal human fibroblasts. At the same time an evident defect of preferential accelerated repair of single-strand breaks in the c-myc gene was observed. DNA single-strand breaks repair in human satellite III and total DNA single-strand breaks in c-myc gene in AT cells correlate with increased radiosensitivity of cells.
Igusheva
O A
OA
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Spivak
I M
IM
Mikhel'son
V M
VM
Pleskach
N M
NM
Zhestianikov
V D
VD
D001260:Ataxia Telangiectasia / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D016259:Genes, myc; D006801:Humans; D012016:Reference Values; D014158:Transcription, Genetic
Defekt preimushchestvennoĭ reparatsii gamma-indutsirovannykh odnonitevykh razryvov b transkribiruemoĭ DNK pri ataksii-teleangiéktazii.