Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides.
On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM.
Strekowski
L
L
Department of Chemistry, Georgia State University, Atlanta 30303, USA.
Zegrocka
O
O
Henary
M
M
Say
M
M
Mokrosz
M J
MJ
Kotecka
B M
BM
Manzel
L
L
Macfarlane
D E
DE
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D002738:Chloroquine / Q000031:analogs & derivatives; D018899:CpG Islands / Q000276:immunology; D007700:Kinetics; D009841:Oligonucleotides / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D000634:Aminoquinolines; D009841:Oligonucleotides; D002738:Chloroquine