Culture-negative ulcerative keratitis after laser in situ keratomileusis.
A 40-year old man, highly myopic in both eyes, had laser in situ keratomileusis (LASIK) in the left eye in November 1996. Corneal melting and ulceration and fine striae-like interface infiltrates were noticed 1 day postoperatively. There was no response to intensive topical antibiotics in the form of hourly ofloxacin 3% (Tarivid), and satellite lesions developed on day 4. Corneal scrapings for gram stain and culture were done twice. No bacterial or fungal organisms were identified. Intensive topical fortified vancomycin (50 mg/mL) was added, and the lesions resolved gradually over the ensuing 2 weeks. Eighteen months after LASIK, refraction was -1.50 - 0.75 x 105 in the left eye, and uncorrected visual acuity was 20/70, correctable to 20/25 with spectacles.
Prince of Wales Hospital, Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Shatin, NT, China.
D S
DS
Lam
A T
AT
Leung
J T
JT
Wu
D S
DS
Fan
A C
AC
Cheng
Z
Z
Wang
D000328:Adult; D000900:Anti-Bacterial Agents; D003315:Cornea / Q000473:pathology / Q000601:surgery; D016039:Corneal Transplantation / Q000009:adverse effects*; D003320:Corneal Ulcer / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects*; D008297:Male; D009216:Myopia / Q000601:surgery; D009883:Ophthalmic Solutions
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions