[Splanchnic hypoperfusion and distant organ injury].
Acute respiratory distress syndrome (ARDS) and multiple organ failure (MOF) are the most common causes of death in surgical intensive care units. A variety of stimuli, such as major surgery, trauma, shock, thermal injury, acute pancreatitis, and ischemia-reperfusion injury, initiate a systemic inflammatory response that contributes to the development of these complications. Splanchnic hypoperfusion is a common clinical event in critically ill patients. Recently, measurement of the adequacy of gut circulation has been demonstrated as an excellent tool for prediction of outcome in these patients. The emphasis of this review is on events associated with intestinal ischemia-reperfusion and subsequent distant organ injury.
Department of Emergency and Critical Care Medicine, Nippon Medical School, Tokyo, Japan.
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Koike
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Yamamoto
D016207:Cytokines / Q000502:physiology; D006801:Humans; D007421:Intestine, Small / Q000098:blood supply; D007511:Ischemia / Q000150:complications*; D008171:Lung Diseases / Q000209:etiology; D013152:Splanchnic Circulation
D016207:Cytokines