[Therapy of increased intracranial pressure in space-occupying media infarcts].
Following complete middle cerebral artery (MCA) infarction, up to 10% of all patients develop space-occupying brain edema. Despite intensive care therapy, 80% of these patients die due to transtentorial herniation. Over the past years, two alternative therapeutical options for the therapy of space-occupying MCA infarction have been developed. Decompressive surgery effectively decreases ICP and helps to improve outcome of these patients. Mortality can be reduced from 80% to less than 20%. Moderate hypothermia induced within the first hours after stroke has been shown to decrease ICP as well. However, the routine use of this therapy should not be recommended since further clinical studies are available. Knowledge on indications and limitations of different antiedema therapies will allow an effective therapy of increased ICP.
Neurologische Klinik, Universität Heidelberg.
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Schwab
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Hacke
D001929:Brain Edema / Q000209:etiology / Q000628:therapy*; D002544:Cerebral Infarction / Q000209:etiology / Q000628:therapy*; D019299:Decompression, Surgical; D006801:Humans; D007036:Hypothermia, Induced; D019586:Intracranial Hypertension / Q000209:etiology / Q000628:therapy*; D007427:Intracranial Pressure / Q000502:physiology*; D014207:Trephining
Therapie des erhöhten intrakraniellen Drucks bei raumfordernden Mediainfarkten.