The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.
Genomic DNA encoding for human aldehyde reductase (AKR1A1), a member of the aldo-keto reductase superfamily, was isolated and characterized. The genomic DNA is approximately 16 kb in length and contains eight exons which encode the entire coding region and the 3'-untranslated sequences. AKR1A1 was localized on chromosome 1p33-->p32 by fluorescence in situ hybridization.
Department of Biochemistry, Osaka University Medical School, Osaka, Japan. jfujii@biochem.med.osaka-u.ac.jp
J
J
Fujii
R
R
Hamaoka
A
A
Matsumoto
T
T
Fujii
Y
Y
Yamaguchi
M
M
Egashira
O
O
Miyoshi
N
N
Niikawa
N
N
Taniguchi
D020413:3' Untranslated Regions / Q000235:genetics; D000449:Aldehyde Reductase / Q000235:genetics*; D000818:Animals; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D051381:Rats
D020413:3' Untranslated Regions; C580929:AKR1A1 protein, human; D000449:Aldehyde Reductase