Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.
The NAD(P)H:quinone oxidoreductase gene, NQO1, often carries a C-->T transition at bp 609, which has been associated with a reduced enzymatic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens. We tested the association of this polymorphism with lung cancer risk in a population-based case-control study of 327 cases and 440 controls of Caucasian, Japanese, or Native Hawaiian ancestry in Hawaii. We found a notable difference in the frequency of the variant allele among Japanese (38%), Caucasians (20%), and Hawaiians (22%). Overall, the variant allele was less frequent in cases than in controls (P = 0.03). A significant inverse association was found in Japanese, with adjusted odds ratios of 0.8 (95% confidence interval, 0.4-1.5) and 0.3 (0.1-0.7) for the heterozygous and homozygous variant genotypes, respectively, compared with the homozygous wild-type genotype (P for genetic trend, 0.02). The association did not reach statistical significance in Caucasians and Hawaiians but was in the same direction.
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Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA.
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Le Marchand
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D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000208:ethnology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013941:Thymine; D044465:White People / Q000235:genetics
D003596:Cytosine; D016660:NAD(P)H Dehydrogenase (Quinone); D013941:Thymine