Evaluation of the body composition and fat distribution in long-term users of hormone replacement therapy.
The aim of the study was to evaluate the body composition and fat distribution in long-term users of hormonal replacement therapy (HRT). 18 healthy menopausal women, long-term users of HRT (transdermal estradiol 50 microg continuously administered and 10 mg/day of medroxyprogesterone acetate for 12 days/month) and 18 healthy menopausal women, who had never used HRT were included in the study. Age, menopausal age, parity, weight and height (body mass index, weight/height2), and lifestyle habits were similar. Waist and hip circumference, body composition and waist/hip ratio were measured and the results were analyzed. No significant difference was demonstrated in fat and water percentage, and waist/hip ratio. Nevertheless, the waist circumference of long-term HRT users was significantly lower than that of non-users. In conclusion, abdominal fat in long-term HRT users is lower than that of non-users of similar age, menopausal age and body mass index.
1st Clinic of Obstetrics and Gynecology, University of Rome 'La Sapienza', Rome, Italy.
G
G
Perrone
Y
Y
Liu
O
O
Capri
C
C
Critelli
F
F
Barillaro
P
P
Galoppi
L
L
Zichella
D000273:Adipose Tissue; D000279:Administration, Cutaneous; D000368:Aged; D000375:Aging; D001823:Body Composition; D001824:Body Constitution; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use; D008593:Menopause; D008875:Middle Aged; D010298:Parity
D004958:Estradiol; D017258:Medroxyprogesterone Acetate