[Change in the sensitivity of influenza virus, replicating in the presence of rimantadine, to antiviral agents].
A variant obtained by a single passage of the initial FPV in the presence of 25 micrograms/ml rimantadine is more resistant to the drug than the parental virus. Sensitivity to rimantadine is higher in a variant obtained similarly by cell culture infection with rimantadine-resistant FPV. Potentiation of the antiviral effect of a combination of ribavirin (12-25 micrograms/ml) and rimantadine (0.1-6 micrograms/ml) is decreased or null if rimantadine dose is increased to 12-25 micrograms/ml; this phenomenon does not depend on the sensitivity of infective virus to rimantadine. Antiviral effect of drug combination with a high concentration of rimantadine is due to ribavirin alone.
E I
EI
Boreko
N I
NI
Pavlova
V I
VI
Votiakov
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D012254:Ribavirin / Q000494:pharmacology; D012299:Rimantadine / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D012299:Rimantadine; D012254:Ribavirin
Izmenenie chuvstvitel'nosti virusa grippa, razmnozhivshegosia v prisutstvii remantadina, k protivovirusnym preparatam.