Intra-articular absorption and distribution of ketoprofen after topical plaster application and oral intake in 100 patients undergoing knee arthroscopy.
OBJECTIVE
The primary objective of this study was to assess the kinetics of ketoprofen in synovial fluid and intra-articular tissues in relation to plasma. The secondary objective was to study whether intra-articular tissues act as reservoirs.


METHODS
The ketoprofen concentration was analysed in plasma, synovial fluid and intra-articular tissues after single application of a 30 mg plaster (n = 40), multiple applications for 5 days (n = 30) or oral intake of 50 mg (n = 30) in patients undergoing knee arthroscopy.


RESULTS
Median CMax values after topical application were 12.8 ng/ml in synovial fluid, 56.7 ng/g in synovial tissue, 349.3 ng/g in meniscus and 568.9 ng/g in cartilage.


CONCLUSIONS
Topical applications of ketoprofen allow the attainment of high intra-articular tissue concentrations.
Department of Orthopaedic Surgery, Huddinge University Hospital, Sweden.
C
C
Rolf
B
B
Engström
C
C
Beauchard
L D
LD
Jacobs
A
A
Le Liboux
D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001182:Arthroscopy; D002370:Casts, Surgical; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007719:Knee Joint / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000737:chemistry; D014018:Tissue Distribution
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen