Estrogen receptor-alpha-immunoreactive neurons in the mesencephalon, pons and medulla oblongata of the female golden hamster.
Recent studies have revealed brainstem-spinal pathways involved in the generation of receptive behavior in hamster and cat, and the enormous influence of estrogen on these pathways. The present study gives an overview of the location of estrogen receptor-alpha-immunoreactive neurons (ER-alpha-IR) in the brainstem of the female hamster. In the mesencephalon, ER-alpha-IR cells were found in the arcuate and peripeduncular nuclei as well as throughout the rostrocaudal extent of the periaqueductal gray (PAG), and the laterally adjoining tegmentum. In the caudal brainstem, groups of ER-alpha-IR cells were present in the ventrolateral parabrachial nucleus, the solitary nucleus, and in contrast to the cat, in the nucleus retroambiguus. No ER-alpha-IR cells were found in any other part of the brainstem. The functional implications of these findings are discussed.
Department of Anatomy and Embryology, Faculty of Medical Sciences, University of Groningen, The Netherlands. j.boers@med.rug.nl
J
J
Boers
P O
PO
Gerrits
E
E
Meijer
G
G
Holstege
D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002415:Cats; D006224:Cricetinae; D047628:Estrogen Receptor alpha; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D008526:Medulla Oblongata / Q000737:chemistry / Q000378:metabolism*; D008636:Mesencephalon / Q000737:chemistry / Q000378:metabolism*; D008647:Mesocricetus; D009474:Neurons / Q000737:chemistry / Q000378:metabolism*; D011149:Pons / Q000737:chemistry / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000032:analysis*
D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen