Chronic lymphocytic leukemia is infrequent in Mexican mestizos.
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults living in Western countries, and accounts for approximately 30% of adult leukemias. In a 15-year period in a single institution, we identified 19 patients with CLL in a group of 211 adults with leukemia (9% of adult leukemias). Of these 19 CLL patients, 8 had a Caucasian phenotype, 4 were born outside the country, and only 11 were Mexican mestizos. On the other hand, in a multicenter experience involving 1968 Mexican adults with leukemia, CLL represented 6.6% of the cases, a figure significantly lower than that reported in Caucasians (P < 0.01). CLL is the least frequent type of leukemia in Mexican mestizos, and this low prevalence may stem from the genetic origin of this racial group. The data also suggest a genetic predisposition of Caucasians to suffer from this disease.
Ruiz-Argüelles
G J
GJ
Laboratorios Clínicos de Puebla, Mexico. gruiz1@pue1.telmex.net.mx
Velázquez
B M
BM
Apreza-Molina
M G
MG
Pérez-Romano
B
B
Ruiz-Reyes
G
G
Ruiz-Argüelles
A
A
D000328:Adult; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D007198:Indians, North American / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology* / Q000235:genetics*; D008800:Mexico / Q000453:epidemiology