Human papillomavirus infection and other risk factors for cervical intraepithelial neoplasia in Japan.
Various risk factors were investigated in 167 cervical intra-epithelial neoplasia (CIN) case and control pairs in Japan. CIN cases showed evidence of nine known risk factors including smoking and sexual behaviour. However, after adjustment for papillomavirus infection, the highest determinant, the only remaining risk factors were: being married, early age at first pregnancy and multiparity.
Yoshikawa
H
H
Department of Obstetrics and Gynecology, University of Tokyo, Japan.
Nagata
C
C
Noda
K
K
Nozawa
S
S
Yajima
A
A
Sekiya
S
S
Sugimori
H
H
Hirai
Y
Y
Kanazawa
K
K
Sugase
M
M
Shimizu
H
H
Kawana
T
T
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D015999:Multivariate Analysis; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D011247:Pregnancy; D012307:Risk Factors; D012725:Sexual Behavior; D012907:Smoking; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology*