Ophthalmic abnormalities in patients with cutaneous T-cell lymphoma.
OBJECTIVE
To determine the frequency of ophthalmic abnormalities in patients with cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome) and T-cell lymphoma involving the skin and to describe the clinical course of the disease with selected examples.


METHODS
Retrospective, clinic-based, cross-sectional study.


METHODS
A computerized diagnostic retrieval system was used to identify all patients with T-cell lymphoma involving the skin who were examined at the Mayo Clinic (Rochester, Minnesota) between January 1, 1976 and December 31, 1990. The medical records of affected patients were reviewed.


METHODS
Identification of ophthalmic abnormalities.


RESULTS
During the 15-year interval from 1976 through 1990, cutaneous T-cell lymphoma was diagnosed in 2155 patients. Of these, 42 (1.95%; 26 male and 16 female) had at least one ophthalmic abnormality attributable to the disease. The diagnoses in these 42 patients were mycosis fungoides in 19, clinical variants of T-cell lymphoma of the skin (most commonly peripheral T-cell lymphoma) in 11, and Sézary syndrome in 12. Cicatricial eyelid ectropion was the most common finding, affecting 17 (40.4%) of the 42 patients. Thirty-seven patients had findings that, although probably not a direct consequence of cutaneous T-cell lymphoma, have been cataloged in previous studies.


CONCLUSIONS
Although ophthalmic abnormalities in patients with cutaneous T-cell lymphoma are relatively uncommon, the manifestations of the disease are diverse and frequently difficult to treat.
Cook
B E
BE
Department of Ophthalmology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
Bartley
G B
GB
Pittelkow
M R
MR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000473:pathology; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000209:etiology* / Q000473:pathology; D005134:Eye Neoplasms / Q000209:etiology / Q000473:pathology; D005142:Eyelid Neoplasms / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications*; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D012751:Sezary Syndrome / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications*