Lacidipine reduces high blood pressure and the target organ damage induced by high fructose diet in rats.
OBJECTIVE
Normotensive rats fed a high fructose diet (HFD) develop hypertriglyceridemia, hyperinsulinemia and hypertension. The glomerular changes observed in the kidneys of these animals are similar to those observed in diabetic rats. The aim of this study was to evaluate whether lacidipine could be effective not only in preventing, but also in inducing the regression of hypertension, and renal and cardiac damage in rats fed HFD.


METHODS
Thirty male Wistar-Kyoto (WKY) rats received HFD for 1 month; thereafter, five rats were sacrificed (Group 1) and the other 25 rats were divided into three groups: Group 2 (five rats) received HFD plus placebo, Group 3 (10 rats) HFD plus lacidipine 3 mg/kg per day, and Group 4 (10 rats) HFD plus hydralazine 10 mg/kg per day. At the end of the second month all animals were sacrificed. Kidneys and hearts were immediately removed. Renal deposits of collagen I, collagen IV, fibronectin and cardiac deposits of collagen III were assessed by means of immunohistochemistry.


RESULTS
In the rats receiving HFD plus placebo, blood pressure was increased after the first and the second month of diet. This increase was reversed by lacidipine and hydralazine but, although both drugs normalized blood pressure, only lacidipine was effective in reducing renal and cardiac damage.


CONCLUSIONS
These data suggest that lacidipine is effective in reversing hypertension and reducing target organ damage induced by HFD. Moreover, this protective effect on target organs appears to be not simply a consequence of blood pressure reduction, but seems to be connected to the type of hypotensive drug administered.
Cosenzi
A
A
Istituto di Medicina Clinica, University of Trieste, Italy.
Bernobich
E
E
Plazzotta
N
N
Seculin
P
P
Odoni
G
G
Bellini
G
G
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism; D004032:Diet; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use; D005353:Fibronectins; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects*; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011921:Rats, Inbred WKY
D000959:Antihypertensive Agents; D004095:Dihydropyridines; D005353:Fibronectins; C060285:lacidipine; D005632:Fructose; D003094:Collagen