Olive oil supplemented with vitamin E affects mitochondrial coenzyme Q levels in liver of rats after an oxidative stress induced by adriamycin.
In this study we have evaluated the supplementation of olive oil with vitamin E on coenzyme Q concentration and lipid peroxidation in rat liver mitochondrial membranes. Four groups of rats were fed on virgin olive, olive plus 200 mg/kg of vitamin E or sunflower oils as lipid dietary source. To provoke an oxidative stress rats were administered intraperitoneally 10 mg/kg/day of adriamycin the last two days of the experiment. Animals fed on olive oil plus vitamin E had significantly higher coenzyme Q and vitamin E levels but a lower mitochondrial hydroperoxide concentration than rats fed on olive oil. Retinol levels were not affected, by either different diets or adriamycin treatment. In conclusion, an increase in coenzyme Q and alpha-tocopherol in these membranes can be a basis for protection against oxidation and improvement in antioxidant capacity.
Nutrition and Food Technology Institute, University of Granada, Spain. jlq@rri.sari.ac.uk
J L
JL
Quiles
M C
MC
Ramirez-Tortosa
J R
JR
Huertas
S
S
Ibañez
J A
JA
Gomez
M
M
Battino
J
J
Mataix
D000818:Animals; D004042:Dietary Fats, Unsaturated; D019587:Dietary Supplements; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D005227:Fatty Acids / Q000032:analysis; D007274:Injections, Intraperitoneal; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D000069463:Olive Oil; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008563:Membrane Lipids; D000069463:Olive Oil; D010938:Plant Oils; D014451:Ubiquinone; D014810:Vitamin E; D004317:Doxorubicin