Phlebosclerosis of the colon with positive anti-centromere antibody.
A 56-year-old woman with symptoms of chronic bowel disease presented a peculiar calcification of the mesenteric vein of the ascending to transverse colon on barium enema study. The resected colon was hard and black. Histo-pathologic examinations demonstrated fibrous change of the colon with a calcified and hyaline-deposited mesenteric vein. No cell infiltration was observed. These findings were compatible with phlebosclerosis and also with systemic sclerosis. Positive anti-centromere antibody and Raynaud's phenomenon, hallmarks of a variant systemic sclerosis, the CREST syndrome were observed. We therefore speculated that the pathogenesis of the phlebosclerosis of the colon is related to the CREST syndrome.
Kitamura
T
T
Department of Internal Medicine, Sumitomo Hospital, Osaka.
Kubo
M
M
Nakanishi
T
T
Fushimi
H
H
Yoshikawa
K
K
Taenaka
N
N
Furukawa
T
T
Tsujimura
T
T
Kameyama
M
M
D001323:Autoantibodies / Q000032:analysis*; D017675:CREST Syndrome / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D002503:Centromere / Q000276:immunology*; D003106:Colon / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008642:Mesenteric Veins / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D011859:Radiography; D012598:Sclerosis; D014652:Vascular Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*
D001323:Autoantibodies