Optical detection of synaptic vesicle exocytosis and endocytosis.
Recent advances in optical methods have catalyzed a detailed study of individual visualized synapses in several model systems. Quantal events at small central synapses, as well as single granule exocytosis in secretory cells, have been detected using quantitative fluorescence imaging. Sensitive detection of exocytosis and endocytosis at individual synapses has advanced our knowledge of synaptic vesicle trafficking.
Department of Molecular & Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. vnmurthy@fas.harvard.edu
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D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D009490:Neurosecretory Systems / Q000166:cytology / Q000502:physiology; D055095:Optics and Photonics; D013572:Synaptic Vesicles / Q000502:physiology*