High serum coenzyme Q10, positively correlated with age, selenium and cholesterol, in Inuit of Greenland. A pilot study.
Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n-6/n-3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S-CoQ10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p < 0.001) compared to a Danish population. In a linear multiple regression model the S-CoQ10 level is significantly positively associated with age and S-selenium in males, and S-total cholesterol in females. The high level of CoQ10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense.
Pedersen
H S
HS
Primary Health Care Clinic, Nuuk, Greenland. hsp@greennet.gl
Mortensen
S A
SA
Rohde
M
M
Deguchi
Y
Y
Mulvad
G
G
Bjerregaard
P
P
Hansen
J C
JC
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism; D001161:Arteriosclerosis / Q000453:epidemiology; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003067:Coenzymes; D003718:Denmark / Q000208:ethnology; D005260:Female; D006116:Greenland / Q000453:epidemiology; D006801:Humans; D004930:Inuit; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D010865:Pilot Projects; D015995:Prevalence; D012307:Risk Factors; D012643:Selenium / Q000097:blood*; D012737:Sex Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D044465:White People
D000975:Antioxidants; D015415:Biomarkers; D003067:Coenzymes; D014451:Ubiquinone; D002784:Cholesterol; C024989:coenzyme Q10; D012643:Selenium