[Generation of reactive forms of oxygen by polymorphonuclear leukocytes during hepatoma growth in the peritoneal cavity of animals].
In the present work, an attempt was made to analyse generation of reactive oxygen species (ROS) by polymorphonuclear leucocytes (PMN) in the course of tumour growth, using chemiluminescence (CL). A multiple increase in the capacity of polymorphonuclear leucocytes of generating active forms of oxygen in the course of tumor growth was discovered. Two causes of this process were found. 1) the increase in specific activity of leucocytes; 2) the increase in the total quantity of PMN circulating in the blood. Leucocytes were also found in the ascite liquid. PMN leucocytes were shown to participate in the antitumor defence of the organism.
Potselueva
M M
MM
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
Pustovidko
A V
AV
Alabin
V S
VS
Evtodienko
Iu V
IuV
D000818:Animals; D002455:Cell Division / Q000502:physiology; D018450:Disease Progression; D008114:Liver Neoplasms, Experimental / Q000097:blood* / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000378:metabolism*; D010529:Peritoneal Cavity; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species
Generatsiia reaktivnykh form kisloroda polimorfnoiadernymi leĭkotsiamiv protsesse razvitiia gepatomy v briushnoĭ polosti zhivotnykh.