Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis.
Amphotericin B has been the standard treatment for deep mycoses including African histoplasmosis, but its use is complicated by its toxicity. More recently, Fluconazole, a water-soluble triazole with antimycotic activity and little side effects, has become available. A case of African histoplasmosis from Nigeria, manifesting as multiple osteomyelitis and successfully treated with oral Fluconazole, is presented. Fluconazole may be preferred in the therapy of African histoplasmosis.
Department of Surgery, University of Nigeria Teaching Hospital, Enugu.
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Onwuasoigwe
D000284:Administration, Oral; D000935:Antifungal Agents / Q000737:chemistry / Q000627:therapeutic use*; D002648:Child; D015725:Fluconazole / Q000737:chemistry / Q000627:therapeutic use*; D006660:Histoplasmosis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009549:Nigeria; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000382:microbiology*; D018579:Patient Selection; D011859:Radiography
D000935:Antifungal Agents; D015725:Fluconazole