Left ventricular opacification by intravenous contrast echocardiography.
BACKGROUND
The present study was undertaken in order to evaluate the efficacy of the intravenous administration of Albunex in obtaining left ventricular opacification and the relationship between left ventricular opacification and pulmonary pressures and cardiac function.


METHODS
Fifty-two adult patients, mostly affected by ischemic heart disease, were enrolled in the study. In 37 of these patients, a complete right heart hemodynamic study was performed after Swan-Ganz catheterization. Albunex was administered in three randomized doses (0.10, 0.15 and 0.20 ml/kg) to all the patients. Left ventricular opacification was assessed both visually and using videodensitometric analysis.


RESULTS
Left ventricular opacification was obtained in 93% of all the injections and an intermediate or strong opacification was obtained in 68%, while absent opacification was observed in 6% of the injections, irrespective of the contrast dose. An incremental opacification efficacy trend was observed from the lower to the higher dose, with an intermediate or strong opacification in 58 and in 77% of 0.10 and 0.20 ml/kg injections, respectively. Irrespective of the contrast dose, an enhancement of the endocardial borders was observed in 61% of the wall segments suboptimally visualized in basal conditions. The endocardial borders enhancement was obtained in 39 and in 79% of segments using the 0.10 and the 0.20 ml/kg doses, respectively. No statistically significant differences were observed between the videodensitometric parameters obtained using the three contrast doses. Finally, a significant relationship was observed between left ventricular opacification parameters and pulmonary pressures and left ventricular functional parameters, irrespective of the contrast doses considered.


CONCLUSIONS
The results we obtained demonstrate the good overall efficacy of Albunex administered intravenously in order to obtain left ventricular opacification in a clinical population of cardiac patients. Moreover, they suggest that the dosage to be used clinically should preferably be at least 0.20 ml/kg, although no significant influence of contrast dosage on videodensitometric parameters has been observed. Finally, irrespective of the contrast dosage, the magnitude of left ventricular opacification appears to be influenced by the hemodynamic status of the patient.
Castini
D
D
Divisione di Cardiologia, Ospedale San Paolo, Università di Milano.
Gentile
F
F
Ornaghi
M
M
Mangiarotti
E
E
Garbin
M
M
Ravaglia
R
R
Gioventù
M
M
Mantero
A
A
Corno
R
R
Limido
A
A
Morandi
F
F
Fiorentini
C
C
Pezzano
A
A
Repetto
S
S
Haider
T
T
Morris
H
H
Marelli
C
C
D000328:Adult; D000368:Aged; D000418:Albumins / Q000008:administration & dosage*; D000704:Analysis of Variance; D003287:Contrast Media / Q000008:administration & dosage*; D003720:Densitometry / Q000379:methods / Q000706:statistics & numerical data; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D016014:Linear Models; D008297:Male; D008863:Microspheres; D008875:Middle Aged
D000418:Albumins; C060687:Albunex; D003287:Contrast Media