Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain.
Using cDNA of human protocadherin 2A (pc2A; originally known as protocadherin 2) as a probe, we cloned a new member of the protocadherin 2 subfamily from mouse brain cDNA libraries and named it protocadherin 2C (pc2C). It was similar to pc2A throughout its entire coding region, and its C-terminal region was highly conserved. The locus of the pc2C gene was on the mouse chromosome 18C where the pc2A gene is located, suggesting that genes of the pc2 subfamily form a gene cluster. The expression of pc2C was restricted to the nervous system, and the expression started in the embryonic stage and increased up to the adult stage. The expression pattern was quite similar to that of OL-protocadherin, a distinct class of protocadherin, although the timing and relative strength of expression were different. These results suggest that pc2C may be involved in neural development along with other classes of protocadherins.
Department of Ophthalmology, Department of Microbiology, University of Southern California School of Medicine, DVRC309, 1450 San Pablo Street, Los Angeles, California, 90033, USA.
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Hirano
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Ono
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Yan
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Wang
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Sonta
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Suzuki
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D015820:Cadherins / Q000737:chemistry / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D003001:Cloning, Molecular; D018507:Gene Expression Regulation, Developmental; D008040:Genetic Linkage; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D000091363:Protocadherins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D015820:Cadherins; C117277:Pcdh10 protein, mouse; C120499:Pcdhga12 protein, mouse; D000091363:Protocadherins; D012333:RNA, Messenger