Congenital CD34-positive granular cell dendrocytosis.
Granular cell tumors involving the skin are mostly acquired lesions. The Schwann cell origin of these lesions is supported by positive immunostaining for S-100 protein and myelin basic protein. S-100- granular cell lesions rarely have been described in association with fibrous papules or dermatofibromas. The congenital variety of S-100- granular cell tumors occurs almost exclusively in the gingiva. The cell origin of these lesions is not well delineated. We report a hitherto undescribed case of a congenital cutaneous lesion which is histologically characterized by diffuse dermal infiltrates of S-100- but CD34+ granular dermal dendrocytes. The granular appearance of these CD34+ dendrocytes is attributed to an abundance of phagolysosomes. The pathogenetic mechanism of this unusual lesion remains to be elucidated.
Chang
S E
SE
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Choi
J H
JH
Sung
K J
KJ
Moon
K C
KC
Koh
J K
JK
Lim
S D
SD
Huh
J
J
Shwayder
T
T
Lee
M W
MW
D018952:Antigens, CD34 / Q000378:metabolism*; D001706:Biopsy; D003594:Cytoplasmic Granules / Q000473:pathology / Q000648:ultrastructure; D003713:Dendritic Cells / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D016586:Granular Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008854:Microscopy, Electron; D010588:Phagosomes / Q000473:pathology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure
D018952:Antigens, CD34