Calcium channelopathies in the central nervous system.
The recent discovery that familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 are allelic disorders caused by different mutations in CACNA1A, a calcium-channel-encoding gene, adds to a growing list of channelopathies causing paroxysmal neurologic disturbance and progressive neurodegeneration. Calcium channelopathies in the central nervous system provide a model to study the important roles that calcium channels play in neuronal function.
Department of Neurology, UCLA School of Medicine, Box 951769, 710 Westwood Plaza, Los Angeles, California 90095-1769, USA. jjen@ucla.edu
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D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002490:Central Nervous System / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D013132:Spinocerebellar Degenerations / Q000503:physiopathology*
D015220:Calcium Channels