Liposomes, micelles and microemulsions as new delivery systems for cytotoxic alkaloids.
This review describes the design and performance of specialized delivery systems, such as liposomes, micellar solutions and microemulsions, for the administration of cytotoxic alkaloids. Special attention is directed towards three types of compound, Vinca, Camptotheca and Taxus alkaloids, which have been previously indicated as of promise as antitumour agents but which still present serious drawbacks. In this respect, this review analyses different delivery strategies that are able to substantially improve the therapeutic applicability of such antitumour drugs.
Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 19, I-44100 Ferrara, Italy.
R
Cortesi
C
Nastruzzi