[Hyalinizing spindle cell tumor with giant rosettes. Case report with immunohistochemical characterization].
This is a case of a 46-years-old male patient with a long-standing history of lower abdominal complaints. A 6-cm measuring tumor was detected by CT and subsequently surgically removed. Classification of this tumor and prognosis was problematic in frozen section and paraffin-embedded material, including immunohistochemical studies. The immunohistochemical findings were compatible with myofibroblastic differentiation of tumor cells. The histologic pattern resembled a "hyalinizing spindle cell tumor with giant rosettes" as recently published. Even if there were certain discrepancies in the immunohistochemical findings in our case, we also recommended treating this tumor as a low-grade sarcoma. The malignancy was also supported by marked proliferative activity demonstrated by MIB 1/KI 67 expression in numerous tumor cells. Finally, it has not yet been determined whether the hyalinizing spindle cell tumor is a pattern associated with a certain cellular differentiation or a pattern common to several mesenchymal tumor types.
Institut für Pathologie, Städt. Krankenhaus München Bogenhausen.
P
P
Meister
I
I
Babaryka
D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D034961:Antigens, Nuclear; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000032:analysis
D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D014746:Vimentin
Hyalinisierter Spindelzelltumor mit Riesenrosetten. Fallbericht mit immunhistochemischer Charakterisierung.