Adequacy of the new guidelines on clinical evaluation of drug efficacy in acute uncomplicated cystitis.
The adequacy of the newly revised criteria for the evaluation of clinical efficacy of antimicrobial agents in acute uncomplicated cystitis harmonized to the IDSA/FDA guidelines was studied. Low bacterial counts were significantly more frequently found in midstream urine than in catheter urine. Non-uropathogens were isolated with significantly higher frequency from patients with bacteriuria of 10(3) colony forming units (cfu)/ml than from patients with higher bacterial counts. It is important to exclude non-uropathogens when patients with bacteriuria of 10(3) cfu/ml are included in the study. Although the clinical failure rate was very low in patients with eradication of the pathogen, the clinical cure rate was only 67% in patients with microbiological failure. Microbiological and clinical outcomes coincided in 93% of the patients. However, the coincidence rate was lower when the eradication rate was low.
Department of Urology, Gifu University School of Medicine, Gifu-shi, Japan.
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Y
Kawada
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Ishihara
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000592:standards*; D003556:Cystitis / Q000188:drug therapy*; D005260:Female; D017408:Guidelines as Topic; D006801:Humans; D010043:Outcome and Process Assessment, Health Care / Q000379:methods*; D014481:United States; D014486:United States Food and Drug Administration
D000900:Anti-Bacterial Agents