CD14.
The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact bacteria or apoptotic cells can result in either pro- or anti-inflammatory responses. Since the CD14 molecule does not have a membrane spanning domain it cannot transmit a signal into the cell. Some as yet unidentified accessory protein is thought to be involved. It will be important to clarify the signalling systems involved since they may provide a therapeutic target for sepsis intervention strategies.
Institut für Immunologie und Transfusionsmedizin, Universität Greifswald, Germany. schuett@rz.uni-greifswald.de
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D000818:Animals; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000737:chemistry* / Q000502:physiology* / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000502:physiology; D018805:Sepsis / Q000628:therapy
D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D011971:Receptors, Immunologic; C048071:endotoxin receptor