Bcl2 and Bax expression in naevi and melanomas and their relation to ploidy status and proliferation.
Twenty-five naevi, 53 primary melanomas, 36 melanoma metastases were stained immunohistochemically for the presence of Bcl2, Bax and Ki-67 antigen in order to define the relation between apoptosis regulators and proliferative activity. Additionally, ploidy status and S-phase were measured. Bax demonstrated a tendency to increase and Bcl2 was decreasing along with melanoma progression. In the group of euploid cases Bcl2 showed a strong significant correlation with Bax expression (p = 0.0001) and both Bcl2 and Bax correlated with Ki-67 expression and S-phase. In the group of aneuploid cases only the correlation Bcl2-Ki-67 was preserved. Others did not reach the level of statistical significance.
Department of Cytopathology, Georg August University, Goettingen, Germany.
M
M
Korabiowska
U
U
Brinck
I
I
Ruschenburg
T
T
Schlott
M
M
Droese
J
J
Stachura
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002455:Cell Division / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009506:Nevus / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D011003:Ploidies; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein