Clostridium difficile-associated diarrhea after short term vaginal administration of clindamycin.
A 32-yr-old woman developed frequent watery diarrhea with occult blood after 3 days treatment with clindamycin vaginal cream. Clostridium difficile toxin was demonstrated in stool samples and was considered the cause of an antibiotic-associated diarrhea. No other antibiotic was used at least 3 months before the start of diarrhea. To our knowledge, antibiotic-associated diarrhea after vaginal application has previously been reported only once.
Department of Medicine, Haukeland Hospital, Bergen, Norway.
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Vikenes
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Lund-Tønnesen
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Schreiner
D000282:Administration, Intravaginal; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002981:Clindamycin / Q000008:administration & dosage / Q000009:adverse effects*; D016360:Clostridioides difficile; D003967:Diarrhea / Q000209:etiology*; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology*; D005260:Female; D006801:Humans
D000900:Anti-Bacterial Agents; D002981:Clindamycin