[Role of renin-angiotensin-aldosterone system in pathogenesis of arterial hypertension in chronic renal failure].
OBJECTIVE
To characterize status of renin-angiotensin-aldosterone system (RAAS) in patients with chronic and terminal renal failure (CRF, TRF) and its role in pathogenesis of arterial hypertension (AH).


METHODS
RAAS was studied in 90 patients with TRF on chronic hemodialysis (CHD) and 17 CRF patients with AH on conservative therapy. Plasma renin activity (PRA) and the level of plasma aldosterone (PA) were measured with radioimmunoassay.


RESULTS
PRA with moderate CHD-controlled hypertension (1.16 ng/ml/h) was not higher than in control group (1.33 ng/ml/h), while in severe hypertension PRA was increased 4.6-fold (6.09, p < 0.05). In CRF with severe AH PRA was higher 3.6 times (4.8 ng/ml/h, p < 0.05). PA was in CRF and TRF patients 4-5 times higher than in healthy controls. A positive correlation was found between PRA and mean dynamic AP (r = 0.448, p < 0.01) and PRA with PA (r = 0.31, p < 0.05).


CONCLUSIONS
A leading role of RAAS is shown in pathogenesis of AH in patients with hemodialysis uncontrolled hypertension and, partially, in patients with CRF and severe AH.
N L
NL
Lifshits
I M
IM
Kutyrina
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D011863:Radioimmunoassay; D006435:Renal Dialysis; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000502:physiology*; D012720:Severity of Illness Index
D015415:Biomarkers; D000450:Aldosterone; D012083:Renin
Rol' renin-angiotenzin-al'dosteronovoĭ sistemy v patogeneze arterial'noĭ gipertonii pri khronicheskoĭ pochechnoĭ nedostatochnosti.