[Severe hepatitis from therapeutic doses of paracetamol in an alcoholic patient].
The case of a 36-year-old chronic alcoholic patient who came to the hospital for presenting general bad shape, arthromyalgia and jaundice and who developed severe hepatitis with an extreme elevation in the transaminase levels following the consumption of therapeutic doses of paracetamol (3 g/day for 4 days). The possibility of other causes of hepatitis were duly discarded. Liver biopsy showed confluent centrolobular necrosis compatible with the diagnosis of toxic hepatitis. The patient was discharged from hospital in stable condition and with a slight alteration in the transaminase levels. Recognizing hepatotoxicity by paracetamol in alcoholics is simple if the clinical history, the marked transaminase elevation and the history of paracetamol intake are adequately evaluated. Lower doses of paracetamol or even avoidance of this drug is recommended in circumstances in which the toxicity of the drug may be potentiated by chronic alcohol consumption or by the lack of appetite associated with deficient alimentation.
Unidad de Hepatología, Hospital Clínic i Provincial, Barcelona.
V
V
Andreu
E
E
Gómez-Angelats
M
M
Bruguera
J
J
Rodés
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000208:Acute Disease; D000328:Adult; D000437:Alcoholism / Q000150:complications*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D013997:Time Factors
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
Hepatitis grave por dosis terapéuticas de paracetamol en un paciente alcohólico.