Structure and function of gustatory neurons in the nucleus of the solitary tract. IV. The morphology and synaptology of GABA-immunoreactive terminals.
In the visual, auditory and somatosensory systems, insight into the synaptic arrangements of specific types of neurons has proven useful in understanding how sensory processing within that system occurs. The neurotransmitter GABA is present in the nucleus of the solitary tract and based on the fact that the vast majority of cells respond to GABA, its agonists and antagonists, and that over 45% of synaptic terminals in the rostral subdivision of the nucleus of the solitary tract are GABA-immunoreactive, GABA is thought to play an important role in gustatory processing. The following study was carried out to establish the distribution of GABA-immunoreactive terminals within the nucleus of the solitary tract. Specifically, the distribution on to physiologically-identified gustatory neurons was determined using post-embedding electron immuno-histochemistry. GABA-immunoreactive terminals synapse with gustatory neuronal somata and all portions of their dendrites, but non-GABAergic terminals synapse only with distal dendrites of the gustatory cells and on to correspondingly small unidentified dendritic profiles in the neuropil. There is a differential distribution of two subtypes of GABA-immunoreactive terminals on to proximal and distal portions of the gustatory neurons as well. Finally, a model for the synaptic arrangements involving gustatory and GABAergic neurons is proposed.
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, KY 40292, USA.
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Leonard
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Renehan
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Schweitzer
D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D009411:Nerve Endings / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D009474:Neurons / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D013649:Taste / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
C070614:neurobiotin; D005680:gamma-Aminobutyric Acid; D001710:Biotin