Changes in nociceptive and anxiolytic responses following herpes virus-mediated preproenkephalin overexpression in rat amygdala are naloxone-reversible and transient.
These results using herpes virus-mediated gene transfer to overexpress enkephalin in the amygdala support the role of amygdalar opioids in the anxiolytic actions of benzodiazepines and supraspinal nociception (see ref. 1). These studies also demonstrate the usefulness of recombinant herpes virus in evaluating the role of single gene products within specific brain sites in pharmacological responses and complex behaviors.
Department of Pharmacology and Physiology, University of South Carolina School of Medicine, Columbia 29208, USA.
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D000679:Amygdala / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D004745:Enkephalins / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects; D005822:Genetic Vectors; D006564:Herpesviridae / Q000235:genetics; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis; D014158:Transcription, Genetic / Q000187:drug effects; D001616:beta-Galactosidase / Q000235:genetics
D014151:Anti-Anxiety Agents; D004745:Enkephalins; D011498:Protein Precursors; D012333:RNA, Messenger; D011994:Recombinant Proteins; D009270:Naloxone; C033660:preproenkephalin; D001616:beta-Galactosidase; D003975:Diazepam