Discordant expression of c-Ret and glial cell line-derived neurotrophic factor receptor alpha-1 mRNAs in response to motor nerve injury in neonate rats.
Adult motoneurons can survive following axotomy, whereas neonate motoneurons result in cell death. Following hypoglossal nerve axotomy in neonate rat, Glial cell line-Derived Neurotrophic Factor (GDNF) receptor alpha-1 (GFRalpha-1) mRNA expression was dramatically suppressed in the injured motoneurons, while a slight increase of c-Ret mRNA expression was observed. In adult, both GFRalpha-1 and c-Ret mRNAs increased substantially after axotomy. The present result suggests that the difference of motoneuron fate after axotomy may be partly due to the coordinate or discordant responses of GFRalpha-1 and c-Ret expression to nerve injury.
Tsujino
H
H
Department of Anatomy, Asahikawa Medical College, Nishikagura 4-5-3-11, Asahikawa, Hokkaido, 078-8510, Japan.
Mansur
K
K
Kiryu-Seo
S
S
Namikawa
K
K
Kitahara
T
T
Tanabe
K
K
Ochi
T
T
Kiyama
H
H
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D019771:Axotomy; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D007002:Hypoglossal Nerve / Q000502:physiology*; D061228:Hypoglossal Nerve Injuries; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012016:Reference Values; D014158:Transcription, Genetic
D029721:Drosophila Proteins; C494989:Gfra1 protein, rat; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C495001:Ret protein, rat