Effects of fujibitol, a remedy for nasal symptoms of immediate and delayed type allergic reactions.
The effects of Fujibitol, a remedy for the nasal symptoms of immediate and delayed type allergic reactions were studied. Fujibitol inhibited active systemic anaphylaxis in mice, heterologous passive cutaneous anaphylaxis (PCA) in rats, Masugi's nephritis in rats and delayed type hypersensitivity induced by picryl chloride in mice, but did not affect homologous PCA or immune complex-induced glomerulonephritis in rats. These results suggested that Fujibitol is effective for treatment of allergy-induced inflammation since IgG and type IV allergic reactions were inhibited.
Kakimoto
M
M
Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Takasugi
N
N
Fuwa
T
T
Saito
H
H
Sugimoto
Y
Y
Kamei
C
C
D000707:Anaphylaxis / Q000188:drug therapy; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000503:physiopathology; D006969:Hypersensitivity, Immediate / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011507:Proteinuria / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000503:physiopathology
D018926:Anti-Allergic Agents; C121689:Fujibitol; D010936:Plant Extracts