Metabolism of an artificial emulsion resembling chylomicrons in patients with multiple myeloma.
Multiple myeloma, as other neoplastic diseases, is accompanied by alterations in lipid metabolism. The metabolism of chylomicrons is unexplored in this condition, despite the importance of these lipoproteins for the energy body supply. Chylomicron metabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. Triglyceride-rich emulsions can mimic chylomicron metabolism in man and are a useful tool to evaluate this metabolic pathway. A double-labeled chylomicron-resembling emulsion was injected into 20 patients with multiple myeloma and 30 normolipidemic healthy subjects. The plasma kinetic curves of the emulsion 3H-triglyceride and 14C-cholesteryl ester were determined in plasma samples collected over 60 minutes. The fractional clearance rate (FCR) of triglycerides in multiple myeloma was not changed compared to controls. However, FCR of cholesteryl esters was smaller in multiple myeloma (0.025 +/- 0.003 and 0.061 +/- 0.010 min(-1), respectively). These results indicate that chylomicron lipolysis is not affected in multiple myeloma, whereas remnant removal is diminished.
Department of Medicine, Hematology and Hemotherapy Section, Faculdade de Ciências Médicas da Santa Casa de São Paulo, Brazil.
V T
VT
Hungria
L I
LI
Brandizzi
C S
CS
Chiattone
S P
SP
Bydlowski
R C
RC
Maranhão
D000328:Adult; D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000172:deficiency; D002788:Cholesterol Esters / Q000097:blood / Q000493:pharmacokinetics*; D002914:Chylomicrons / Q000378:metabolism*; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007009:Hypolipoproteinemias / Q000209:etiology; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood / Q000493:pharmacokinetics*
D001053:Apolipoproteins; D002788:Cholesterol Esters; D002914:Chylomicrons; D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D002784:Cholesterol