Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis.
We investigated the antimycobacterial role of myeloperoxidase (MPO), one of the most abundant granule proteins in human neutrophils. Our data indicate that purified MPO, in the presence of hydrogen peroxide, exerts a consistent killing activity against Mycobacterium tuberculosis H37Rv and against a clinical isolate. The activity is time and dose dependent and requires the presence of chloride ions in the assay medium.
Dipartimento di Fisiologia e Patologia, Università di Trieste, 34127 Trieste, Italy.
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Borelli
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Banfi
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Perrotta
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Zabucchi
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009195:Peroxidase / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D006861:Hydrogen Peroxide; D009195:Peroxidase