Acquired aphasia in acute disseminated encephalomyelitis.
A 12-year-old boy developed a convulsion, hemiparesis, and acquired aphasia with paroxysmal electroencephalogram (EEG) abnormalities consisting of repetitive spikes and waves in the left centro-parietal region. T2-weighted magnetic resonance imaging disclosed high intensity lesions in the left pre-Sylvian and right frontal areas. He was diagnosed as having acute disseminated encephalomyelitis, and thus the oral administration of phenytoin and steroid pulse therapy were begun. With these treatments, his hemiparesis disappeared and the aphasia also improved gradually. Magnetic resonance imaging examination revealed the disappearance of the previously noted abnormalities, and the EEG abnormalities disappeared as well. This patient is a rare case of acute disseminated encephalomyelitis presenting an acquired aphasia. A focal lesion of acute disseminated encephalomyelitis may be responsible for the acquired aphasia. The distinction from Landau-Kleffner syndrome is also discussed.
Yoshikawa
H
H
Department of Pediatrics, Niigata City General Hospital, Niigata, Japan. yos@seagreen.ocn.ne.jp
Oda
Y
Y
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D001037:Aphasia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D004569:Electroencephalography; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010243:Paralysis / Q000188:drug therapy / Q000209:etiology; D010672:Phenytoin / Q000627:therapeutic use; D013256:Steroids; D015899:Tomography, Emission-Computed, Single-Photon
D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D013256:Steroids; D010672:Phenytoin