QSAR study on 1-benzyl-4[w(substituted phthalimido)alkyl]piperidines:acetyl cholinesterase inhibitors.
QSAR studies on a series of 18 piperidine derivatives, which act as acetyl cholinesterase (AchE) inhibitors, have been performed using van der Waals volume (V omega) and topochemical index (tau). Significant correlations have been obtained, which make it clear that AchE inhibition activity is controlled dominantly by topo chemical index.
Chemistry Department, University of Allahabad, India.
A K
AK
Srivastava
A
A
Khare
S
S
Agrawal
P
P
Srivastava
D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D008954:Models, Biological; D010880:Piperidines / Q000378:metabolism*; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D010880:Piperidines; D002795:Choline O-Acetyltransferase