Biological considerations with pelvic neoplasms.
The strategy of therapy for any neoplasm is determined to a significant degree by the biological characteristics of the neoplasm. The ones benefited most by surgical ablation are the cancers that grow locally but never metastasize. The second group is composed of neoplasms with exceedingly slow growth rates permitting long periods of symptom-free survival before recidivation. Many such cancers occur in pelvic structures requiring understanding of the nature of the cancers and then techniques necessary for their resection. The review provides an introduction to some of the relevant biological considerations.
Spratt
J S
JS
Division of Surgical Oncology, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA.
Meyer
J S
JS
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002455:Cell Division; D002813:Chondrosarcoma / Q000473:pathology / Q000601:surgery; D002817:Chordoma / Q000601:surgery; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D006801:Humans; D009362:Neoplasm Metastasis; D010386:Pelvic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy; D011379:Prognosis; D011553:Pseudomyxoma Peritonei / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy; D012445:Sacrococcygeal Region; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000601:surgery