Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome.
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.
Department of Cardiology, University Hospital, Malmö, Sweden. johan.holm@medforsk.mas.lu.se
J
J
Holm
A
A
Hillarp
B
B
Zöller
L
L
Erhardt
E
E
Berntorp
B
B
Dahlbäck
D020016:Activated Protein C Resistance / Q000235:genetics* / Q000503:physiopathology; D000208:Acute Disease; D000368:Aged; D000483:Alleles; D003327:Coronary Disease / Q000235:genetics* / Q000503:physiopathology; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors
D005165:Factor V