Novel feline autoimmune blistering disease resembling bullous pemphigoid in humans: IgG autoantibodies target the NC16A ectodomain of type XVII collagen (BP180/BPAG2).
In humans and dogs, bullous pemphigoid (BP) is an autoimmune blistering disease associated with the production of basement membrane autoantibodies that target the 180-kd type XVII collagen (BP180, BPAG2) and/or the 230-kd plakin epidermal isoform BPAG1e (BP230). In two adult cats, an acquired dermatosis and stomatitis was diagnosed as BP subsequent to the fulfillment of the following criteria: 1) presence of cutaneous vesicles, erosions, and ulcers; 2) histologic demonstration of subepidermal vesiculation with inflammatory cells, including eosinophils; 3) in vivo deposition of IgG autoantibodies at the epidermal basement membrane zone; and 4) serum IgG autoantibodies targeting a 180-kd epidermal protein identified as type XVII collagen. In both cats, the antigenic epitopes targeted by IgG autoantibodies were shown to be situated in the NC16A ectodomain of type XVII collagen, a situation similar to that of humans and dogs with BP. Feline BP therefore can be considered a clinical, histopathologic, and immunologic homologue of BP in humans and dogs.
Department of Companion Animal and Special Species, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA. Thierry_Olivry@ncsu.edu
T
T
Olivry
L S
LS
Chan
L
L
Xu
P
P
Chace
S M
SM
Dunston
M
M
Fahey
M P
MP
Marinkovich
D000818:Animals; D001323:Autoantibodies / Q000302:isolation & purification; D001485:Basement Membrane / Q000276:immunology; D002371:Cat Diseases / Q000276:immunology* / Q000473:pathology; D002415:Cats; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D008297:Male; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
D001323:Autoantibodies; D007074:Immunoglobulin G; D003094:Collagen