Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor.
To search useful compounds in Citrus fruit for cancer chemoprevention, we carried out a primary screening of extracts of fruit peels and seeds from 78 species of the genus Citrus and those from two Fortunella and one Poncirus species, which were closely related to the genus Citrus. These Citrus extracts inhibited the Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) as a useful screening method for anti-tumor promoters. Our results indicated that Citrus containing substances may be inhibit susceptibility factors involved in the events leading to the development of cancer.
Iwase
Y
Y
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.
Takemura
Y
Y
Ju-ichi
M
M
Kawaii
S
S
Yano
M
M
Okuda
Y
Y
Mukainaka
T
T
Tsuruta
A
A
Okuda
M
M
Takayasu
J
J
Tokuda
H
H
Nishino
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000502:physiology; D000998:Antiviral Agents / Q000494:pharmacology; D002051:Burkitt Lymphoma / Q000188:drug therapy; D002273:Carcinogens; D002642:Chick Embryo; D002957:Citrus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013755:Tetradecanoylphorbol Acetate; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects*
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D000998:Antiviral Agents; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate