[Soluble adhesion molecules (P-selectin, ICAM-1 and ICAM-3) in rheumatoid arthritis].
OBJECTIVE
Investigation of serum levels and clinical role of soluble intercellular molecules of adhesion (pICAM-1, PICAM-3 and pP-selectin) in rheumatoid arthritis (RA).


METHODS
Enzyme immunoassay with Bender MedSystem kits (Austria) was employed to measure serum concentration of soluble intercellular molecules of adhesion in 36 RA patients.


RESULTS
Elevated levels of serum pICAM-1, pICAM-3 and pP-selectin were registered in 74.2, 28.6 and 25.7% of RA patients, respectively. Content of pP-selectin more strongly correlated with activity and severity indices than that of pICAM-3 (p < 0.001). Content of pICAM-1 and clinical picture of RA were unrelated.


CONCLUSIONS
Levels of pP-selectine can characterize RA activity.
Nasonov
E L
EL
Samsonov
M Iu
MIu
Tilz
G P
GP
Nikiforova
E L
EL
Chichasova
N V
NV
Imametdinova
G R
GR
Ilich-Stoianovich
O
O
Baranov
A A
AA
Fuchs
D
D
Nasonova
V A
VA
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D000943:Antigens, Differentiation; D018771:Arthralgia / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques / Q000295:instrumentation; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D012995:Solubility
D015703:Antigens, CD; D000943:Antigens, Differentiation; D015415:Biomarkers; D015815:Cell Adhesion Molecules; C483616:ICAM3 protein, human; D019007:P-Selectin; D011933:Reagent Kits, Diagnostic; D018799:Intercellular Adhesion Molecule-1
Rastvorimye molekuly adgezii (P-selektin, ICAM-1 i ICAM-3) pri revmatoidnom artrite.