Ovarian volume may predict assisted reproductive outcomes better than follicle stimulating hormone concentration on day 3.
This study was undertaken to compare ovarian volume with other factors which are important for the success of assisted reproduction. The first treatment cycle for 261 patients meeting all entry criteria between September 1993 and June 1995 was considered. All cycles employed the same stimulation protocol and no interventions were based upon pre-treatment indicators. Pre-treatment ovarian volumes, cycle day 3 follicle stimulating hormone (FSH) and oestradiol concentrations, smoking status and age were compared to subsequent peak oestradiol concentrations, numbers of oocytes retrieved, cycle cancellation and occurrence of clinical pregnancy. Statistical evaluation was performed using simple and multiple logistic regression analysis to determine odds ratios. The resultant odds ratios suggest that age and small ovarian volume may predict retrieval of fewer mature oocytes, while the failure to achieve clinical pregnancy was predicted by current smoking and small ovarian volume. Day 3 FSH values failed to be a significant predictor when maternal age, smoking status and ovarian volume were known. It can be concluded that, like maternal age and smoking status, ovarian volume may be a clinically important predictor of reproductive success, being superior to cycle day 3 FSH or oestradiol concentrations as an assessment of ovarian reserve.
Syrop
C H
CH
Department of Obstetrics & Gynecology, Department of Preventive Medicine, University of Iowa College of Medicine, 200 Hawkins Drive, Iowa City, IA, 52242-1080, USA.
Dawson
J D
JD
Husman
K J
KJ
Sparks
A E
AE
Van Voorhis
B J
BJ
D000328:Adult; D002452:Cell Count; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D008423:Maternal Age; D008875:Middle Aged; D016017:Odds Ratio; D009865:Oocytes / Q000166:cytology; D010053:Ovary / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D011247:Pregnancy; D012099:Reproductive Techniques; D012907:Smoking / Q000009:adverse effects; D016896:Treatment Outcome; D014463:Ultrasonography
D004958:Estradiol; D005640:Follicle Stimulating Hormone