[Acute myelocytic leukemia and plasmacytoma secondary to chemotherapy and radiotherapy in a long-term survivor of small cell lung cancer].
A 68-year-old man was given a diagnosis of lung cancer of the right upper lobe (small cell carcinoma, T 4 N 2 M 0, stage IIIB) in February 1991. The tumor diminished after chemotherapy and radiotherapy. In February 1992, a partial resection of the lower lobe of the right lung was performed because of the appearance of a metastatic tumor. In September 1994, squamous cell carcinoma developed in the lower part of the esophagus, but disappeared after radiotherapy. In February 1998, a diagnosis of myelodysplastic syndrome was made. Two months later, the patient had an attack of acute myelocytic leukemia and died of cardiac tamponade. An autopsy determined that both the lung cancer and esophageal cancer had disappeared. Acute myelocytic leukemia and plasmacytoma of lymph nodes in the irradiated area were confirmed. These were regarded as secondary malignancies induced by chemotherapy and radiotherapy.
Department of Pathology, Osaka Medical College, Japan.
K
K
Fukunishi
T
T
Kurokawa
A
A
Takeshita
K
K
Nariyama
Y
Y
Egashira
Y
Y
Shibayama
K
K
Kamei
T
T
Oue
S
S
Hashimoto
Y
Y
Fukuda
K Y
KY
Min
N
N
Ohsawa
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D018288:Carcinoma, Small Cell / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000628:therapy; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000209:etiology*; D010954:Plasmacytoma / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D013534:Survival