Chromosome segregation: Samurai separation of Siamese sisters.
How do cells ensure that sister chromatids are precisely partitioned in mitosis? New studies on budding yeast have revealed that sister chromatid separation at anaphase requires endoproteolytic cleavage of a protein that maintains the association between sister chromatids.
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria. mglotzer@nt.imp.univie.ac.at
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D000705:Anaphase / Q000502:physiology; D000818:Animals; D018797:Cell Cycle Proteins; D002842:Chromatids / Q000502:physiology; D002843:Chromatin / Q000502:physiology; D020090:Chromosome Segregation; D005656:Fungal Proteins / Q000235:genetics; D005800:Genes, Fungal / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D004718:Saccharomycetales / Q000235:genetics; D012568:Schizosaccharomyces / Q000235:genetics; D064249:Securin; D014981:Xenopus
D018797:Cell Cycle Proteins; D002843:Chromatin; D005656:Fungal Proteins; D009687:Nuclear Proteins; C578004:PDS1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D064249:Securin