[Genetic-epidemiologic study of adenoma and cancer of the large intestine].
A clinical/genealogical study of colorectal adenomas (CRA) and cancer (CRC), and multiple primary malignant tumors (MPMT) was performed. The CRA prevalence in the population was 4.7 +/- 1.4% (single CRA--6.3% and multiple CRA--3.0%). The frequencies of malignant adenomas, 0.7% CRC, and MPMT were 0.7, 0.17 +/- 0.07%, and 0.004 +/- 0.003%, respectively. The prevalence of cancer of the female reproductive organs was also estimated (cancer of uterine body, 0.2 +/- 0.1%; cancer of ovaries, 0.08 +/- 0.1%; cancer of uterine cervix, 0.55 +/- 0.1%; cancer of mammary gland 0.57 +/- 0.1%). The main parameters of the familial inheritance of adenomas, CRC, and MPMT were also studied in general and at various clinical variants of these pathologies. Among the first-degree relatives of patients with solitary and multiple adenomas, the adenoma frequencies were 5.9 +/- 0.6 and 3.7 +/- 0.5%, respectively. The CRC frequency among the first-degree relatives of patients with adenoma was 3.0 +/- 0.6% and the frequency of MPMT was 5.8 +/- 0.6%. On the basis of the data obtained on frequencies of malignant tumors in various groups of relatives, the following conclusions were made: (1) in families of each proband group, specific pathology was accumulated; (2) the familial frequency of malignant tumors increased with an increase in proliferative processes and the severity of a pathology in probands.
Belev
N F
NF
Institute of Oncology, Ministry of Health of The Republic of Moldova, Chisinau, Russia.
Samotyia
E E
EE
Pikhut
P M
PM
Kudina
E N
EN
Khalipli
S D
SD
Trubnikov
V I
VI
Kazubskaia
T P
TP
Gar'kavtseva
R F
RF
D000236:Adenoma / Q000453:epidemiology / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology; D006801:Humans; D007414:Intestinal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D007420:Intestine, Large; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology
Genetiko-épidemiologicheskoe issledovanie adenom i raka tolstoĭ kishki.