Antibacterial effect of garlic and omeprazole on Helicobacter pylori.
The antibacterial effect of a home-made raw garlic extract and commercial garlic tablets alone and in combination with antibiotics or omeprazole was determined against clinical isolates of Helicobacter pylori. MIC values of raw garlic extract and three types of commercial garlic tablets ranged from 10,000 to 17,500 mg/L. When MIC values of the commercial tablets were based on the allicin content, no differences between the three types were observed. The combination of garlic and omeprazole, studied with killing curves, showed a synergic effect which was concentration dependent. Further clinical evaluation of garlic in combination with the conventional agents for H. pylori treatment seems warranted.
Department of Medical Microbiology, University Hospital Maastricht, The Netherlands.
D
D
Jonkers
E
E
van den Broek
I
I
van Dooren
C
C
Thijs
E
E
Dorant
G
G
Hageman
E
E
Stobberingh
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005737:Garlic / Q000737:chemistry*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009853:Omeprazole / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D009853:Omeprazole