Synthesis and identification of conformationally constrained selective MMP inhibitors.
We have discovered a new series of potent conformationally constrained MMP Inhibitors that are selective for MMP-13 over MMP-1.
Freskos
J N
JN
Department of Medicinal Chemistry, Searle Discovery Research, St Louis, MO 63198, USA.
McDonald
J J
JJ
Mischke
B V
BV
Mullins
P B
PB
Shieh
H S
HS
Stegeman
R A
RA
Stevens
A M
AM
D017364:Collagenases / Q000378:metabolism; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D020781:Matrix Metalloproteinase 1; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D017364:Collagenases; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; D020784:Matrix Metalloproteinase 8; D020781:Matrix Metalloproteinase 1