Dynamics of Helicobacter pylori colonization in relation to the host response.
The dynamics of Helicobacter pylori colonization from its acquisition through the development of steady-state are examined through a mathematical model that includes the host response. The model encompasses both host and microbiological variation. The individual capacity of the host response is shown to be a key model parameter, leading to either transient or persistent colonization, whereas the growth rate of that response has little effect. Analyses of competing strains indicate that each must occupy a specific niche, otherwise exclusion occurs. The model implies that there exists a lower bound on the host response to the indigenous microflora that is consistent with current biological views of H. pylori. Parallel models may be useful in understanding other persistent host-microbial interactions.
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
M J
MJ
Blaser
D
D
Kirschner
D002455:Cell Division; D005753:Gastric Mucosa / Q000382:microbiology; D005838:Genotype; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007700:Kinetics; D008962:Models, Theoretical