Abortive apoptosis as an initiator of chromosomal translocations.
Apoptosis is a well-recognized regulator of a cell populations size and structure. Irreversible stages of apoptosis lead to activation of different enzymatic cascades, changes in cell morphology and DNA fragmentation. However, little is known about nuclear events which accompany the initial stages of apoptosis. These events are connected with introduction of limited amounts of double strand breaks into genomic DNA, some of which may be subsequently rejoined. We hypothesize here that the initial stages of apoptotic DNA fragmentation may be reversible and connected with the initiation of recombinational events and certain chromosomal translocations. The factors influencing apoptosis reversibility and cell survival after delivery of apoptotic stimuli may provide new insights into mechanisms of lymphocyte development and tumorigenesis.
Department of Radiotherapy, Loyola University Medical Center, Maywood, IL 60153, USA. nkhodar@luc.edu
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Khodarev
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Sokolova
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Vaughan
D017209:Apoptosis / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000235:genetics / Q000378:metabolism; D053938:DNA Fragmentation; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D004247:DNA