[Pneumonitis induced by the drug ougon].
We report a case of drug-induced pneumonitis associated with the herbal medications Sho-saiko-to and Ouren-gedoku-to. A 62-year-old man experienced fever and dry cough after using Ouren-gedoku-to for 2 months. He was admitted to our hospital because a subsequent 5-day course of Sho-saiko-to for suspected bronchitis aggravated these symptoms and caused exertional dyspnea. Chest X-ray films revealed a ground-glass appearance in both lower lung fields. Cessation of these medications improved the patient's clinical and X-ray findings. Bronchoalveolar lavage showed an increase in lymphocytes with a decreased CD 4/CD 8 ratio. While drug-induced lymphocyte stimulation tests gave negative results, challenge tests for Ouren-gedoku-to and Sho-saiko-to were both positive. A diagnosis of drug-induced pneumonitis was made. Our findings suggested the involvement of Ougon, the only common ingredient in the two medications.
Division of Respiratory Medicine, Hiratsuka Kyosai Hospital, Kanagawa, Japan.
F
F
Nishimori
K
K
Yamazaki
Y
Y
Jin
N
N
Yoshimura
K
K
Tsukimoto
H
H
Beppu
M
M
Ichioka
Y
Y
Yoshizawa
D016516:CD4-CD8 Ratio; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D031364:Scutellaria baicalensis
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; C061676:oren gedoku to; C018142:saiko-keishi-to