Comparative antimicrobial activity of an essential oil and an amine fluoride/stannous fluoride mouthrinse in vitro.
Although laboratory studies are not necessarily predictive of clinical activity; they can help to elucidate mechanisms underlying clinical activity when the latter has been established. In a recent clinical study, an essential oil mouthrinse (Listerine Antiseptic) was shown to be significantly more effective than an amine fluoride/stannous fluoride mouthrinse (Meridol) in inhibiting supragingival plaque formation. This paper reports the results of laboratory studies comparing the antimicrobial effectiveness of these 2 mouthrinses using a kill kinetics assay and a plaque biofilm kill assay. In both assays, the essential oil mouthrinse was considerably more effective than the amine fluoride/stannous fluoride mouthrinse. These findings are consistent with the results of the clinical trial and may help to explain the observed differences in clinical activity.
The Warner-Lambert Company, Morris Plains, NJ 07950, USA.
P H
PH
Pan
M B
MB
Finnegan
L
L
Sturdivant
M L
ML
Barnett
D000588:Amines / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004396:Coloring Agents; D003773:Dental Plaque / Q000382:microbiology; D004338:Drug Combinations; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006801:Humans; D007780:Lacticaseibacillus casei / Q000187:drug effects; D009067:Mouthwashes / Q000494:pharmacology*; D009822:Oils, Volatile / Q000494:pharmacology*; D018713:Prevotella intermedia / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology*; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology*; D014002:Tin Fluorides / Q000494:pharmacology*; D014059:Tongue / Q000382:microbiology
D000588:Amines; D000891:Anti-Infective Agents, Local; D004396:Coloring Agents; D004338:Drug Combinations; D009067:Mouthwashes; D009822:Oils, Volatile; D012459:Salicylates; D013729:Terpenes; D014002:Tin Fluorides; C059813:Meridol; C057473:Listerine