Successful treatment of oxidative stress in vitiligo.
Patients with vitiligo have low catalase levels in their involved and uninvolved epidermis in association with high levels of hydrogen peroxide (H2O2). H2O2 has been confirmed for the first time in vivo using Fourier Transform Raman spectroscopy. A topical substitution with a UVB-activated pseudocatalase can successfully remove epidermal H2O2 in vitiligo. This approach leads to recovery of the oxidative damage in the epidermis and remarkable repigmentation in this disorder.
Schallreuter
K U
KU
Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK. K.Schallreuter@bradford.ac.uk
D002118:Calcium / Q000502:physiology / Q000627:therapeutic use; D002374:Catalase / Q000378:metabolism / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006706:Homeostasis; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D011621:Pteridines / Q000378:metabolism; D012867:Skin / Q000737:chemistry / Q000201:enzymology; D014466:Ultraviolet Rays; D014820:Vitiligo / Q000378:metabolism* / Q000628:therapy*
D011621:Pteridines; D006861:Hydrogen Peroxide; D002374:Catalase; D002118:Calcium