Immunity to poliomyelitis, diphtheria and tetanus in pediatric patients before and after renal or liver transplantation.
Few studies have considered the safety, efficacy and appropriateness of vaccinations in pediatric patients before and after solid organ transplantation. The aim of this study was to evaluate the immune status after primary vaccination to diphtheria, tetanus and poliomyelitis in pediatric patients before and after hepatic transplantation and to poliomyelitis in pediatric patients before and after renal transplantation. All the patients had received a complete primary immunization schedule for diphtheria and tetanus and poliomyelitis. Immunity to the three polioviruses was evaluated in 56 patients with renal transplant, 27 on chronic dialysis and 33 controls and in 39 patients with hepatic transplant, 25 with chronic hepatic failure and their 36 controls. Immunity to diphtheria and tetanus was evaluated in 52 liver transplant patients, 29 children with chronic hepatic failure and 54 healthy children. Renal transplant patients were less protected and had lower antibody geometric mean titers than healthy controls for polioviruses 1 and 2. Whereas, protection in the children liver transplant patients was similar to that in their controls. Patients with chronic hepatic failure had higher antibody geometric mean titers to diphtheria and polioviruses 1 and 3 than their control group. Immunosuppression after transplantation has a negative influence on the immune status after primary vaccination in children with renal transplant. Whereas children with chronic hepatic failure have higher antibodies than a normal population. When possible, it could be advisable to individualize immunization schedules in patients at high risk.
Department of Pediatrics, University of Milano Medical School, Italy.
A
A
Balloni
B M
BM
Assael
L
L
Ghio
C
C
Pedrazzi
G
G
Nebbia
B
B
Gridelli
E
E
Melada
A
A
Panuccio
M
M
Foti
M
M
Barbi
C
C
Luraschi
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D016031:Liver Transplantation; D011051:Poliomyelitis / Q000276:immunology*; D013742:Tetanus / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007166:Immunosuppressive Agents