Synthetic analogues of irlbacholine: a novel antifungal plant metabolite isolated from Irlbachia alata.
Irlbacholine and a series of related analogues were synthesized and their antifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbacholine, was the most potent compound, its 22-carbon chain length appearing to be optimal.
Lu
Q
Q
Shaman Pharmaceuticals, 213 East Grand Avenue, South San Francisco, California 94080-4812, USA.
Ubillas
R P
RP
Zhou
Y
Y
Dubenko
L G
LG
Dener
J M
JM
Litvak
J
J
Phuan
P W
PW
Flores
M
M
Ye
Z
Z
Gerber
R E
RE
Truong
T
T
Bierer
D E
DE
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002489:Central America; D003455:Cryptococcus neoformans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013020:South America
D000935:Antifungal Agents; D010767:Phosphorylcholine; C120728:irlbacholine; C039128:miltefosine