Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.
Obukowicz
M
M
G.D. Searle, Discovery Pharmacology, St. Louis, Missouri 63198, USA. mark.g.obukowicz@monsanto.com
Welsch
D
D
Salsgiver
W
W
Martin-Berger
C
C
Chinn
K
K
Duffin
K
K
Raz
A
A
Needleman
P
P
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004487:Edema / Q000517:prevention & control*; D044943:Fatty Acid Desaturases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D012515:Mast-Cell Sarcoma; D051379:Mice; D019301:Oleic Acid / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004042:Dietary Fats, Unsaturated; D010879:Piperazines; C120986:SC 26196; C112313:p-isopentoxyaniline; D016718:Arachidonic Acid; D019301:Oleic Acid; D044943:Fatty Acid Desaturases