Split skin grafts in the treatment of pyoderma gangrenosum. A report of four cases.
BACKGROUND
Pyoderma gangrenosum (PG) is an uncommon necrotising, non-infective ulceration of the skin. The management of PG is aimed at limiting tissue destruction, promoting the healing of the wound, and providing an acceptable cosmetic result. However, skin grafting is normally avoided because of the potential risk of pathergy-the localization of skin damaged by trauma.


METHODS
We describe the use of split skin grafts in the management of ulcerative pyoderma gangrenosum in 4 patients.


RESULTS
Our cases demonstrate that split skin grafts are a useful treatment modality in patients with ulcerative PG, producing a good cosmetic result. One case illustrates the importance of ensuring the disease is quiescent prior to grafting, to avoid pathergy. The other cases emphasise the need for prolonged immunosuppressive therapy to minimise the chance of reactivation of the disease process.


CONCLUSIONS
Our preliminary experience of 4 cases of ulcerative PG indicates that split skin grafts have a role to play in its management. The ultimate cosmetic result is considered to be superior to allowing the wound to heal by secondary intention. To limit the risk of pathergy developing, our experience suggests a role for prolonged courses of immunosuppressive therapy. The most effective dose and duration of immunosuppressive therapy in patients with PG treated with split skin grafts remains to be determined. A controlled study would be of benefit to compare it with other current treatment options.
Department of Dermatology, St Helier Hospital, London, UK.
S
S
Cliff
C A
CA
Holden
P R
PR
Thomas
R A
RA
Marsden
C C
CC
Harland
D000005:Abdomen; D000328:Adult; D000368:Aged; D001132:Arm; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D017511:Pyoderma Gangrenosum / Q000473:pathology / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods