Plasma ubiquinol-10 as a marker for disease: is the assay worthwhile?
Ubiquinol-10 and ubiquinone-10 were measured in plasma of patients with several pathologies known to be associated with increased oxidative stress. Plasma ubiquinol-10, expressed as a percentage of total ubiquinol-10 + ubiquinone-10, was found to be significantly lower in hyperlipidaemic patients and in patients with liver diseases than in age-matched control subjects. In contrast, no decrease in ubiquinol-10 was detected in plasma of patients with coronary heart disease and Alzheimer's disease. Except for ubiquinol-10, no other lipophilic antioxidant was found to be decreased in patients with liver diseases. These data suggest that the level of ubiquinol-10 in human plasma may serve as a marker for liver dysfunction, reflecting its diminished reduction by the liver rather than increased consumption by oxidants.
Kontush
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Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany. kontush@uke.uni-hamburg.de
Schippling
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Spranger
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Beisiegel
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D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008107:Liver Diseases / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D018384:Oxidative Stress; D012016:Reference Values; D015203:Reproducibility of Results; D014280:Triglycerides / Q000097:blood; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood*
D015415:Biomarkers; D014280:Triglycerides; D014451:Ubiquinone; C026663:ubiquinol-10; D002784:Cholesterol; C025204:Ubiquinone Q2