Diamond-like carbon coating and plasma or glow discharge treatment of mechanical heart valves.
All mechanical heart valves (MHV) are thrombogenic. Application of surface modification technology to reduce the incidence of thrombus formation on MHV is a novel undertaking. This requires collaboration within the bioengineering and cardiothoracic surgery fields. From reviewing results of recent and past investigations, and our own preliminary study with diamond-like carbon coating (DLC) and plasma or glow discharge treatment (GDT) of MHV, we identify and discuss several potentially beneficial effects that may reduce the extent of valve-related thrombogenesis by surface modification. DLC and GDT may affect the surfaces of MHV in many ways, including cleaning of organic and inorganic debris, generating reactive and functional groups on the surface layers without affecting their bulk properties, and making the surfaces more adherent to endothelial cells and albumin and less adherent to platelets. These different effects of surface modification, separately or in combination, may transform the surfaces of MHV to be more thromboresistant in the vascular system.
Department of Surgery, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Cooper Health System, Camden, USA.
H S
HS
Tran
M M
MM
Puc
C W
CW
Hewitt
D B
DB
Soll
S W
SW
Marra
V A
VA
Simonetti
J H
JH
Cilley
A J
AJ
DelRossi
D000818:Animals; D020099:Coated Materials, Biocompatible; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D013499:Surface Properties; D013927:Thrombosis / Q000517:prevention & control*
D020099:Coated Materials, Biocompatible