Prevention of chromosomal aberration in mouse bone marrow by indole-3-carbinol.
In this study, we report the protective effect of indole-3-carbinol (I3C), one of the glucobrassicin derivative isolated from cruciferous vegetables against cyclophosphamide induced chromosomal aberrations in mouse bone marrow cells. The three test doses namely 1000,500 and 250 mg/kg b.wt. of I3C provided protection when given 48 h prior to the single i.p. administration of cyclophosphamide (50 mg/kg). I3C alone did not induce chromosomal aberrations at the test doses of 1000 and 500 mg/kg b.wt.. Thus tested glucobrassicin derivative seems to have a preventive potential against cyclophosphamide induced chromosomal aberrations in Swiss mouse bone marrow cells at the doses tested.
Environmental Carcinogenesis Laboratory, Industrial Toxicology Research Centre, Lucknow, India. intox@itrc.sirnetd.ernet.in
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Agrawal
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Kumar
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice
D016587:Antimutagenic Agents; D007211:Indoles; C016517:indole-3-carbinol