Multiple cerebral infarctions associated with ovarian hyperstimulation syndrome.
A 26-year-old woman on human menopausal gonadotrophin-human chorionic gonadotrophin therapy for sterility showed multiple cerebral infarctions associated with ovarian hyperstimulation syndrome. A hypercoagulable state (hemoconcentration, increased plasma levels of D-dimer and thrombin-antithrombin III complex, and decreased protein S activity) was associated with her thromboembolic events. Cerebral infarction associated with mild neurologic deficits may be overlooked in patients with ovarian hyperstimulation syndrome.
Yoshii
F
F
Department of Neurology, Tokai University School of Medicine, Isehara, Japan. yoshii@is.icc.u-tokai.ac.jp
Ooki
N
N
Shinohara
Y
Y
Uehara
K
K
Mochimaru
F
F
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008596:Menotropins / Q000009:adverse effects*; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D010062:Ovulation Induction / Q000009:adverse effects*; D010447:Peptide Hydrolases / Q000032:analysis; D017293:Protein S / Q000032:analysis; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D017293:Protein S; C046193:antithrombin III-protease complex; D008596:Menotropins; D000990:Antithrombin III; D010447:Peptide Hydrolases