Trend for an association between schizophrenia and D3S1310, a marker in proximity to the dopamine D3 receptor gene.
There is considerable controversy regarding a putative association between schizophrenia and a biallelic BalI polymorphism in the first exon of the dopamine D3 receptor gene (DRD3), although meta-analyses of published data suggest an association. If such an association exists, it may be detectable at markers physically close to DRD3. Accordingly, we conducted a case-control association study using D3S1310, a short tandem repeat polymorphism located approximately 700 kb telomeric to DRD3 on chromosome 3q13.3. The subjects were Swedish patients with schizophrenia (DSM III-R criteria, n = 110) and screened adult controls (n = 83). A trend for a negative association with the 141 bp allele was detected (chi2 = 7.6, d.f. = 1, P = 0.006; odds ratio 0.46, 95% confidence intervals 0.26, 0.81). However, following corrections for multiple comparisons using subgroups (n = 15) the difference was not significant. Also, due to the risk for population stratification in case-control association studies the results must be treated as tentative. If replicated the results may lend further support for the proposition of an association between schizophrenia and DRD3 or a gene in close proximity to DRD3 on chromosome 3q.
Jönsson
E G
EG
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden. erikj@psyk.ks.se
Nimgaonkar
V L
VL
Zhang
X R
XR
Shaw
S H
SH
Burgert
E
E
Crocq
M A
MA
Chakravarti
A
A
Sedvall
G C
GC
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009010:Monte Carlo Method; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3