Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations.
For reconstruction of the severely resorbed lateral maxilla for dental implant placement, one of the successful procedures is to elevate the maxillary sinus floor by implanting demineralized bone matrix (DBM). We studied bone formation in DBM grafts in the lateral maxilla in humans by means of histology and histomorphometry. Six months after grafting, at the time of dental implantation biopsies were taken from the grafted areas of seven patients. All biopsies contained mineralized matrix (MM) in the grafted area. At close inspection, three types of mineralization were found. First, lamellar biomineralization was seen in and near the maxillary host bone. Second, remineralization was observed in some particles that probably had not been completely demineralized. In the area connecting the graft and host bone, where woven bone was formed against DBM particles, a third mechanism was detected. In this case many dotlike foci of remineralization appeared close to the bone-DBM interface. The remineralized DBM and woven bone were both subsequently remodeled. Bone formation was most active in the area adjoining the maxillary host bone. We conclude that in human sinus floor elevation, allogenic DBM increases mineralized tissue volume by osteoconduction that is supported by the remineralization processes. Osteoinduction by this material seems questionable.
Department of Oral Cell Biology, ACTA, Vrije Universiteit, Amsterdam, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
E H
EH
Groeneveld
J P
JP
van den Bergh
P
P
Holzmann
C M
CM
ten Bruggenkate
D B
DB
Tuinzing
E H
EH
Burger
D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D001706:Biopsy; D001857:Bone Matrix / Q000033:anatomy & histology / Q000378:metabolism* / Q000637:transplantation*; D002113:Calcification, Physiologic; D015921:Dental Implants; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D016348:Osseointegration; D013997:Time Factors; D014184:Transplantation, Homologous
D001672:Biocompatible Materials; D015921:Dental Implants