[Characteristics of reactogenic and immunogenic properties of the children's variant of the domestic vaccine, "Gep-A-in-Vak", against hepatitis A].
Russian cultural concentrated inactivated vaccine protecting from hepatitis A--Hep-A-in-vac was used for immunization of children. The vaccine is slightly reactogenic and completely safe in children aged 3-17 years vaccinated twice in a dose of 0.25 ml. Double immunization of seronegative children with a 1-month interval led to conversion in 89.7% children. In 64.1% children titers of antibodies to hepatitis A virus reached 20 mIU/ml and higher, which indicates rather high antigenic activity of the vaccine.
Ikoev
V N
VN
Gorbunov
M A
MA
Maĭdaniuk
A G
AG
Karpovich
L G
LG
Kalashnikova
T V
TV
Bektimirov
T A
TA
Karpova
E V
EV
Nemtsov
Iu V
IuV
Muntlieva
M A
MA
Kriuk
N I
NI
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006506:Hepatitis A / Q000517:prevention & control*; D022362:Hepatitis A Vaccines; D006801:Humans; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000627:therapeutic use
D000914:Antibodies, Viral; D022362:Hepatitis A Vaccines; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines
Kharakteristika reaktogennykh i immunogennykh svoĭstv detskogo varianta otechestvenoĭ vaktsiny protiv gepatita A "Gep-A-in-Vak".