Gene related to stroke in stroke-prone spontaneously hypertensive rats.
1. In order to study genes related to stroke in stroke-prone spontaneously hypertensive rats (SHRSP), linkage analysis was performed using F2 rats (SHRSP/Izm x WKY/Izm). The brainweight that reflected cerebral stroke in F2 rats showed cosegregation with three genetic markers, D4Mit19 (P < 0.0015), D4Mgh7 (P < 0.0014) and D4Mgh8 (P < 0.004) on chromosome 4, but not blood pressure. 2. These results suggest that a chromosomal region other than the region responsible for hypertension contributes to the development of stroke in SHRSP.
Ikeda
K
K
Otsuka Department of International Preventive Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
Yamori
Y
Y
D000818:Animals; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000235:genetics*; D002874:Chromosome Mapping; D006973:Hypertension / Q000235:genetics*; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY