Mobile gene cassettes and integrons in evolution.
Integrons and the site-specific recombination systems encoded by them provide a simple mechanism for the addition of new genes to bacterial chromosomes. Although there is substantial divergence among the four known integron-encoded integrases, they all recognize the recombination sites, known as 59-base elements, that are associated with genes that are packaged in gene cassettes. In contrast, the integron-associated recombination sites, attl sites, are preferentially recognized by the cognate integrase.
Sydney Laboratory, NSW, Australia.
R M
RM
Hall
C M
CM
Collis
M J
MJ
Kim
S R
SR
Partridge
G D
GD
Recchia
H W
HW
Stokes
D001483:Base Sequence; D001665:Binding Sites; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D019426:Integrases; D008969:Molecular Sequence Data; D011995:Recombination, Genetic
D004251:DNA Transposable Elements; D019426:Integrases