Trace element transfer from the mother to the newborn--investigations on triplets of colostrum, maternal and umbilical cord sera.
OBJECTIVE
To investigate the trace element transfer from the mother to the newborn.


METHODS
The concentrations of the eight essential elements calcium (Ca), cobalt (Co), copper (Cu), magnesium (Mg), manganese (Mn), molybdenum (Mo), tin (Sn), and zinc (Zn), and of the non-essential and toxic elements barium (Ba), beryllium (Be), bismuth (Bi), cadmium (Cd), cesium (Cs), lanthanum (La), lithium (Li), lead (Pb), rubidium (Rb), antimony (Sb), strontium (Sr), and thallium (Tl) were determined in umbilical cord (n = 29) and corresponding maternal sera (n = 29) as well as in colostrum (n = 27).


RESULTS
Umbilical cord serum concentrations of Ca, Mn, and Zn were 120%, 150%, and 148% of the maternal value, respectively. Maternal sera had twice the Cu concentrations found in healthy adults and five-times higher Cu than umbilical cord sera. Concentration ratios colostrum/maternal serum and colostrum/umbilical cord serum were approximately one for Co, 1.4 for Mg, two for Ca, Mn, and Sn, five for Cu (maternal serum), eight for Mo, and ten for Zn. Concentrations of the toxic elements Cd and Pb decreased in the order colostrum (Pb 2.6 microg/L; Cd 0.6 microg/L), maternal sera (0.8 microg/L; 0.3 microg/L), umbilical cord sera (0.4 microg/L; 0.2 microg/L). Maternal serum Ba and Rb was 182% and 66% of the umbilical cord value. For Sr and Li, an almost perfect correlation between umbilical cord and maternal sera was found. For Ba, Co, Cu, Mn, Zn none, and for Ca, Cs, Mn, Mo, Rb only weak positive correlations between these two compartments could be established.


CONCLUSIONS
The results of this study indicate that an active transport mechanism for the transport of Ca, Mn, Rb, and Zn from the mother to the newborn exists, whereas Cs, Li, and Sr follow concentration gradients. As regards Cu, the placenta showed to have a blocking effect on the transfer from the mother to the baby.
Krachler
M
M
Institute for Analytical Chemistry, Karl-Franzens-Universität Graz, Austria.
Rossipal
E
E
Micetic-Turk
D
D
D000328:Adult; D001693:Biological Transport, Active; D003126:Colostrum / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012016:Reference Values; D014131:Trace Elements / Q000032:analysis / Q000097:blood*
D014131:Trace Elements