Characteristics, circuit, mechanism, and ablation of reentry in the rabbit atrioventricular node.
BACKGROUND
The circuitry underlying AV nodal reentry remains debated. We developed a model of AV nodal reentry and assessed the role of nodal inputs, compact node, and its posterior nodal extension (PNE) in this phenomenon.


RESULTS
A fine scanning of short coupling interval range with an atrial premature beat consistently initiated slow-fast AV nodal reentrant beats that occurred 37+/-31 msec (mean+/-SD) after His-bundle activation in 11 of 16 consecutive rabbit heart preparations. The repeated testing (>40 times) of a chosen coupling interval within reentry window (6+/-9 msec, n = 11) yielded reentrant intervals that varied by 2+/-1 msec (mean SD for 40 beats+/-SD, n = 11). The breakthrough point of reentrant activation, as assessed from four perinodal sites, varied in different preparations from diffuse (4) to anterior (1), medial (3), or posterior (3); mean reentrant interval did not differ between perinodal sites. Antegrade perinodal activation pattern did not differ at reentrant versus nonreentrant coupling intervals and thus was not a primary determinant of reentry. A PNE ablation (n = 4) interrupted the slow pathway conduction and prevented reentry without affecting antegrade perinodal activation or fast pathway conduction.


CONCLUSIONS
A reproducible model of AV nodal reentrant beats was developed and used to study underlying circuitry. The AV nodal reentry involves unaltered antegrade perinodal activation, slow PNE conduction and retrograde broad invasion of perinodal tissues starting at a preparation-dependent breakthrough point. A PNE ablation abolishes the reentry.
Lin
L J
LJ
Département de Physiologie, Faculté de Médecine, Université de Montréal, Québec, Canada.
Billette
J
J
Khalife
K
K
Martel
K
K
Wang
J
J
Medkour
D
D
D000818:Animals; D001283:Atrioventricular Node / Q000503:physiopathology* / Q000601:surgery; D002036:Bundle of His / Q000503:physiopathology / Q000601:surgery; D017115:Catheter Ablation; D004195:Disease Models, Animal; D004562:Electrocardiography; D006339:Heart Rate; D011817:Rabbits; D015203:Reproducibility of Results; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery