Muscle metaboreflex contribution to sinus node regulation during static exercise: insights from spectral analysis of heart rate variability.
BACKGROUND
It is currently assumed that during static exercise, central command increases heart rate (HR) through a decrease in parasympathetic activity, whereas the muscle metaboreflex raises blood pressure (BP) only through an increase in sympathetic outflow to blood vessels, because when the metaboreflex activation is maintained during postexercise muscle ischemia, BP remains elevated while HR recovers. We tested the hypotheses that the muscle metaboreflex contributes to HR regulation during static exercise via sympathetic activation and that the arterial baroreflex is involved in the HR recovery of postexercise muscle ischemia.


RESULTS
Eleven healthy male volunteers performed 4-minute static leg extension (SLE) at 30% of maximal voluntary contraction, followed by 4-minute arrested leg circulation (ALC). Autonomic regulation of HR was investigated by spectral analysis of HR variability (HRV), and baroreflex control of heart period was assessed by the spontaneous baroreflex method. SLE resulted in a significant increase in the low-frequency component of HRV that remained elevated during ALC. The normalized high-frequency component of HRV was reduced during SLE and returned to control levels during ALC. Baroreflex sensitivity was significantly reduced during SLE and returned to control levels during ALC when BP was kept elevated above the resting level while HR recovered.


CONCLUSIONS
The muscle metaboreflex contributes to HR regulation during static exercise via a sympathetic activation. The bradycardia that occurs during postexercise muscle ischemia despite the maintained sympathetic stimulus may be explained by a baroreflex-mediated increase in parasympathetic outflow to the sinoatrial node that overpowers the metaboreflex-induced cardiac sympathetic activation.
Dipartimento di Medicina Interna, Università di Roma "Tor Vergata," Rome, Italy. iellamo@med.uniroma2.it
F
F
Iellamo
P
P
Pizzinelli
M
M
Massaro
G
G
Raimondi
G
G
Peruzzi
J M
JM
Legramante
D000328:Adult; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001919:Bradycardia / Q000503:physiopathology*; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012849:Sinoatrial Node / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*