Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice.
Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Thl) responses producing gamma-interferon (gammaIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased gammaIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Thl response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response.
Research Laboratories, Chlorella Industries Co., Ltd, Chikugo City, Fukuoka, Japan. hasegawa@chlorella.co.jp
T
T
Hasegawa
K
K
Ito
S
S
Ueno
S
S
Kumamoto
Y
Y
Ando
A
A
Yamada
K
K
Nomoto
Y
Y
Yasunobu
D000284:Administration, Oral; D000818:Animals; D002364:Caseins / Q000276:immunology*; D002708:Chlorella / Q000737:chemistry*; D000939:Epitopes / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D006358:Hot Temperature; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000097:blood; D007155:Immunologic Factors / Q000302:isolation & purification / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D051379:Mice; D008811:Mice, Inbred DBA; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D014867:Water / Q000737:chemistry
D002364:Caseins; D000939:Epitopes; D007155:Immunologic Factors; D012333:RNA, Messenger; D014867:Water; D018664:Interleukin-12; D007073:Immunoglobulin E; D007371:Interferon-gamma; D005620:Freund's Adjuvant