[Matrix metalloproteinases. Potential targets for new treatments in inflammatory demyelinating diseases of the nervous system].
Inflammatory demyelinating diseases of the nervous system, such as multiple sclerosis or the Guillain-Barré syndrome represent severely disabling disorders, often seen by the neurologist, with still only limited means for therapeutical intervention. The underlying pathomechanisms remain in large part elusive, however mounting evidence suggests that enzymes of the family of matrix metalloproteinases are of relevance in the pathogenesis of these disorders. Experimental in vivo data as well as results from other medical fields emphasize that the selective inhibition of these proteases could be a promising therapeutical approach. The following review summarizes the role of matrix metalloproteinases in inflammatory demyelinating diseases of the central as well as peripheral nervous system and discusses the therapeutical application of synthetic inhibitors in these disorders.
Kieseier
B C
BC
Neurologische Universitätsklinik, Karl-Franzens-Universität, Graz.
Seifert
T
T
Hartung
H P
HP
D001327:Autoimmune Diseases / Q000503:physiopathology* / Q000628:therapy*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003711:Demyelinating Diseases / Q000503:physiopathology* / Q000628:therapy*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology / Q000628:therapy; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000201:enzymology / Q000276:immunology; D066298:In Vitro Techniques; D008297:Male; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000628:therapy; D009444:Neuritis, Autoimmune, Experimental / Q000503:physiopathology / Q000628:therapy; D011129:Polyradiculoneuropathy / Q000503:physiopathology / Q000628:therapy
D016207:Cytokines; D008666:Metalloendopeptidases
Matrix-Metalloproteinasen. Mögliche Ansatzpunkte neuer Therapien bei entzündlich demyelinisierenden Erkrankungen des Nervensystems.