Inhibition of mouse ear edema by steroidal and triterpenoid saponins.
Certain steroids and triterpenoids isolated from diverse plant families were known to possess anti-inflammatory activity. In the course of finding new anti-inflammatory natural products, some steroidal and triterpenoid saponins were isolated and evaluated for their anti-inflammatory activity using in vivo mouse ear edema test. At the oral dose of 100 mg/kg, several steroidal saponins and triterpenoid saponins such as hederagenin glycosides showed significant inhibition of ear edema (20-37% inhibition), though less potent than indomethacin and hydrocortisone.
College of Pharmacy, Kangwon National University, Chunchon, Korea.
S Y
SY
Kim
K H
KH
Son
H W
HW
Chang
S S
SS
Kang
H P
HP
Kim
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000633:toxicity; D003436:Croton Oil / Q000633:toxicity; D004431:Ear, External / Q000187:drug effects*; D004487:Edema / Q000139:chemically induced / Q000276:immunology*; D006854:Hydrocortisone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012503:Saponins / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D016718:Arachidonic Acid; D009828:Oleanolic Acid; D003436:Croton Oil; C025763:hederagenin; D006854:Hydrocortisone; D007213:Indomethacin