Cerebellar papillary meningioma in a 3-year-old boy: the usefulness of electron microscopy for diagnosis.
We report one case of papillary meningioma located in the posterior fossa in a 3-year-old boy. Despite a gross total resection, a major recurrence occurred 6 months later that was operated on. Eight months later, another recurrence was observed with intracranial metastases and dissemination throughout the cerebrospinal fluid. The tumor had a papillary architecture more obvious in the recurrence. Areas of necrosis were numerous. Tumor cells had large clear atypical nuclei. Many mitotic figures were seen and Ki-67 labeling index was high. The tumor cells were immunoreactive for vimentin and polysialylated neural cell adhesion molecule only, ruling out a diagnosis of ependymoma or medulloblastoma. Diagnosis of meningioma was done by electron microscopy, which showed interdigitating cytoplasmic processes and cell junctions. Cytogenetic study revealed unusual karyotypic abnormalities.
Bouvier
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Department of Pathology and Neuropathology, CHU Timone, Marseille, France.
Zattara-Canoni
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H
Daniel
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Gentet
J C
JC
Lena
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Figarella-Branger
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D
D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003388:Cranial Fossa, Posterior / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D019394:Ki-67 Antigen; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; D014746:Vimentin; C103469:polysialyl neural cell adhesion molecule