mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription.
Eukaryotic mRNA precursors are processed at their 3' ends by a coupled cleavage/polyadenylation reaction. In recent years, most of the factors involved in 3'-end processing have been identified and evidence has been presented for the coupling of mRNA 3'-end formation to capping, splicing and transcription. These links are important for the quality control of the mRNA during synthesis.
Minvielle-Sebastia
L
L
Department of Cell Biology, Biozentrum University of Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland. minvielle@ubaclu.unibas.ch
Keller
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D000818:Animals; D006801:Humans; D011061:Poly A / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D012322:RNA Precursors; D012333:RNA, Messenger; D011061:Poly A