[Recurrent pulmonary infarction associated with familial protein S deficiency type III].
A 38-year-old woman was admitted to our hospital because of recurrent chest pain and fever. Chest X-ray films and computed tomograms showed subpleural consolidation containing small cavity-like opacities. Open lung biopsy revealed non-infectious abscess and vessels with organizing thrombus. The patient was given a diagnosis of pulmonary infarction due to the existence of deep venous thrombosis. Coagulation studies demonstrated that she had decreased plasma protein S activity, whereas her free and total protein S antigen levels were normal. Because her mother and maternal uncle and aunt also demonstrated decreased protein S activity with normal plasma protein S antigen levels, the patient was considered to be affected by familial protein S deficiency type III.
Ide
K
K
Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.
Chida
K
K
Suda
T
T
Imokawa
S
S
Tsukamoto
K
K
Todate
A
A
Sato
J
J
Yonekawa
O
O
Nakamura
H
H
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018455:Protein S Deficiency / Q000150:complications* / Q000235:genetics; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence; D020246:Venous Thrombosis / Q000150:complications; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin