Steroid-DNA conjugates: improved triplex formation with 5-amido-(7-deoxycholic acid)-dU incorporated oligonucleotides.
The synthesis of oligodeoxyribonucleotides incorporating 7-deoxycholic acid conjugated at C5 of dU is described. When used as third strand, these form oligonucleotide triplexes with higher stability compared to unmodified controls at physiological pH.
Bhatia
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D
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, India.
Yue-Ming
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L
Ganesh
K N
KN
D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry* / Q000528:radiation effects; D013256:Steroids / Q000737:chemistry* / Q000378:metabolism*; D013696:Temperature; D014466:Ultraviolet Rays; D014498:Uracil / Q000737:chemistry
D009841:Oligonucleotides; D013256:Steroids; D014498:Uracil; D004247:DNA