Quantitative structure-activity relationship study of iodinated analogues of trimetoquinol as highly potent beta 2-adrenoceptor ligands.
Trimetoquinol and its derivatives, reported to be highly potent beta 2-adrenoceptor (beta 2-AR) and site-selective thromboxane A2/prostaglandin H2 (TP) receptor ligands are subjected to quantitative structure-activity relationship (QSAR) study. From the significant correlation equation, obtained between the binding affinity, pKi (beta 2-AR) and the substitutional physicochemical parameters such as molar refraction, (MR), hydrophobic constant, (pi) and resonance parameter, (R), the receptor binding interactions associated with the varying sites of these compounds are discussed. The QSAR study has also explored the possibilities of having the analogous of improved binding affinities in future synthetic efforts. Likewise, the ratio of binding affinities, expressed as-log[Ki(beta 2-AR)/Ki alpha(TP)] related to two receptors are significantly correlated with MR and pi of the substituents and the relationship may, therefore, be helpful in developing the agents of greater selectivity on beta 2-AR versus TP receptor and vice versa.
Department of Chemistry, S.K. Government College, Sikar, India.
R
R
Kumar
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P
Singh
D000318:Adrenergic beta-Agonists / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D007455:Iodine; D008024:Ligands; D008954:Models, Biological; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism*; D012044:Regression Analysis; D013329:Structure-Activity Relationship; D014213:Tretoquinol / Q000031:analogs & derivatives* / Q000378:metabolism*
D000318:Adrenergic beta-Agonists; D008024:Ligands; D018343:Receptors, Adrenergic, beta-2; D007455:Iodine; D014213:Tretoquinol