Experimental studies on application of small-caliber vascular prosthesis produced by polyurethane.
It has been suggested that a microporous structure enhances fast and complete endothelialization. For long-term patency, antithrombogenicity and microporous structure are very important factors. In this paper, we have developed a new technique to give a micro-porous structure to small-caliber vascular prosthesis produced by polyurethane which has favorable antithrombogenecity. A mixed solution (tetrahydrofuran: dimethylformamide = 1:1) containing 13 wt% of segmented polyurethane and a variable amount of calcium carbonate (mean particle size of 8 mm in diameter) was dip-coated on a glass mandril of 3 mm and 6 mm in diameter and placed into distilled water for 24 hours. After the glass mandrill was removed, this polyurethane tube was placed into 1 mmol hydrochloric acid for 1 hour, and a microporous polyurethane vascular prosthesis of 20 mm in length was completed. These prostheses of 3 mm and 6 mm in diameter were implanted into the femoral and the carotid arteries, and the abdominal aorta of the dogs, respectively. Patency was recognized by arteriography and Duplex scanning and the removed grafts were inspected macro- and microscopically. Greater hydraulic permeability of this graft was obtained with an increase in the quantity of calcium carbonate mixed with polyurethane. In elasticity, this graft was more similar to the canine jugular vein than the polytetrafluoroethylene graft. Patency was observed 8 weeks after implantation on the arteriogram, and neointima was observed microscopically on the smooth and lustrous lumen. The new polyurethane vascular prosthesis we developed might provide a potential prosthesis for small-caliber vascular reconstruction.
Miyamoto
K
K
Department of Surgery, Division II, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Sugimoto
T
T
Okada
M
M
Maeda
S
S
D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery; D001672:Biocompatible Materials / Q000737:chemistry; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D002119:Calcium Carbonate / Q000737:chemistry; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000601:surgery; D004126:Dimethylformamide / Q000737:chemistry; D004285:Dogs; D004548:Elasticity; D004730:Endothelium, Vascular / Q000502:physiology; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery; D005343:Fibrinolytic Agents / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D005898:Glass; D006851:Hydrochloric Acid / Q000737:chemistry; D010316:Particle Size; D010539:Permeability; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D016062:Porosity; D011474:Prosthesis Design; D011859:Radiography; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D017539:Tunica Intima / Q000473:pathology; D018616:Ultrasonography, Doppler, Duplex; D014654:Vascular Patency
D001672:Biocompatible Materials; D005343:Fibrinolytic Agents; D005663:Furans; D011140:Polyurethanes; D012997:Solvents; C018674:tetrahydrofuran; D004126:Dimethylformamide; D011138:Polytetrafluoroethylene; D002119:Calcium Carbonate; D006851:Hydrochloric Acid