The transition from hyperplasia to invasive carcinoma of the breast.
The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.
Lakhani
S R
SR
Department of Histopathology, University College London Medical School, U.K. s.lakhani@ucl.ac.uk
D000818:Animals; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000235:genetics; D051379:Mice; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000235:genetics*