In vivo brain myo-inositol levels in children with Down syndrome.
The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the "idiogenic osmole," myo-inositol, in brain cells. To determine whether the levels of myo-inositol are increased in the basal ganglia of children with Down syndrome, we performed in vivo brain hydrogen 1-nuclear magnetic resonance or 1H-magnetic resonance spectroscopy and measured plasma osmolality in a cohort of children with trisomy 21. Myo-inositol is elevated in the corpus striatum of infants and children with Down syndrome, even in the absence of hypertonic stress.
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
G T
GT
Berry
Z J
ZJ
Wang
S F
SF
Dreha
B M
BM
Finucane
R A
RA
Zimmerman
D000293:Adolescent; D001479:Basal Ganglia / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007294:Inositol / Q000097:blood*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009994:Osmolar Concentration
D007294:Inositol