Acute leukemias in children from the city of Kiev and Kiev region after the Chernobyl NPP catastrophe.
During 1993-1997, 247 cases of childhood acute leukemia (AL) were analyzed among inhabitants of the city of Kiev and Kiev region, excluding the most contaminated areas belonging to the strict control zone. The criteria of an FAB classification supplemented by immunophenotyping data were applied. The AL pattern was shown to be quite typical except for several peculiar features characteristic of this regional group of patients, especially the absence of age peaks in children with acute myelogenous leukemias (AML), increased frequency of the T1 variant in T-cell acute lymphoblastic leukemia (ALL), and higher levels of M4 and M5 variants in AML. A typical variant of M5a-AML with minimal signs of differentiation was found.
RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
D F
DF
Gluzman
I V
IV
Abramenko
L M
LM
Sklyarenko
V A
VA
Nadgornaya
M P
MP
Zavelevich
N I
NI
Bilous
L Y
LY
Poludnenko
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology*; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology*; D008297:Male; D011210:Power Plants; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*; D018788:Radioactive Hazard Release; D014455:Ukraine / Q000453:epidemiology