Ceftriaxone associated hemolysis.
A 48-year-old immunocompetent women treated with ceftriaxone 2 g daily i.v. for late Lyme borreliosis developed severe haemolytic anaemia. The patient had previously received the same antibiotic two times without any side effects. The first clinical signs began to appear on the seventh day of treatment. The patient developed severe anaemia with a haemoglobin level of 45 mg/l on day 10; thereafter she ceased to receive the antibiotic. The outcome was favourable. The clinical course and serologic results suggest that severe anaemia was induced by ceftriaxone and that drug adsorption as well as immune complex mechanisms were involved in the pathogenesis.
Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia.
V
V
Maraspin
S
S
Lotric-Furlan
F
F
Strle
D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced*; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D008193:Lyme Disease / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged
D002511:Cephalosporins; D002443:Ceftriaxone