Treatment of chronic pain with antiepileptic drugs: a new era.
BACKGROUND
Shortcomings of traditional pain relief agents have led physicians to investigate other alternatives, such as antiepileptic drugs. Safe, effective, nonhabituating agents are currently available to enhance pain treatment strategies.


METHODS
In this article, various pharmacologic options and their mechanisms of action are reviewed briefly, with a focus on treatment of chronic pain with antiepileptic drugs (AEDs).


RESULTS
Antiepileptic drugs have been widely studied and prescribed for the relief of acute and chronic pain. Similarities in the neurophysiology of pain and epilepsy suggest that AEDs may be a suitable adjunct in the management of chronic pain. Of the newer AEDs, gabapentin shows the greatest potential and appears to be well tolerated by patients.


CONCLUSIONS
Treatment of chronic pain remains a challenge for physicians and patients. Further research is required to identify the role of various agents and their effect on patient return to function and quality of life.
Department of Anesthesia and Pain Medicine, Davis Medical Center, Statesville, NC, USA.
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Hansen
D000085:Acetates / Q000494:pharmacology / Q000627:therapeutic use; D000588:Amines; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D006801:Humans; D009475:Neurons, Afferent / Q000145:classification / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D011957:Receptors, Opioid / Q000187:drug effects; D013126:Spinal Nerve Roots / Q000187:drug effects; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D011957:Receptors, Opioid; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin