Toxicity of oxidized fats II: tissue levels of lipid peroxides in rats fed a thermally oxidized corn oil diet.
Male Wistar albino rats were fed for 21 days on a diet in which fat (12%) was included either as fresh corn oil, malonaldehyde content = 0.11+/-0.05 micro microg/g (control) or thermally oxidized corn oil, malonaldehyde content = 0.20+/-0.03 microg/g (experimental) and the tissue levels of lipid peroxides in six organs-namely, liver, kidney, brain, heart, lungs and testes-were determined. Of the organs studied, significantly (P < 0.1) higher concentrations of lipid peroxides were observed only in the liver and kidney of the experimental rats. In the course of the feeding, the experimental rats showed significantly (P < 0.1) lower gains in body weights as well as higher relative liver weights than the control rats.
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State.
B C
BC
Nwanguma
A C
AC
Achebe
L U
LU
Ezeanyika
L C
LC
Eze
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003314:Corn Oil / Q000633:toxicity*; D006358:Hot Temperature; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
D008054:Lipid Peroxides; D003314:Corn Oil