[A case of lung cancer with hypercalcemia and renal failure responsive to pamidronate].
A 46-year-old man was diagnosed as Stage IV lung cancer with neck lymph node and bilateral adrenal metastases. He was treated with seven courses of combined chemotherapy (CDDP + etoposide), until he showed extreme hypercalcemia and acute renal failure. The bisphosphonate, pamidronate with elcatonin and prednisolone dramatically lowered his serum calcium level and normalized his renal function. This is a representative case of humoral hypercalcemia of malignancy whose serum calcium could be safely and effectively controlled with pamidronate.
Second Dept. of Internal Medicine, Kohseiren Takaoka Hospital.
H
H
Koshida
T
T
Kametani
S
S
Masuda
D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D004164:Diphosphonates / Q000627:therapeutic use*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000077268:Pamidronate; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D051437:Renal Insufficiency / Q000209:etiology* / Q000503:physiopathology
D000970:Antineoplastic Agents; D004164:Diphosphonates; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D005047:Etoposide; D000077268:Pamidronate; D002945:Cisplatin