Anti-carcinogenic activity of Taraxacum plant. I.
An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on the two-stage carcinogenesis of mouse skin tumor induced by dimethylbenz[a] anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter, as well as on that induced by DMBA and fumonisin B1. Further, the extract exhibited anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexen amide (NOR-1) as an initiator and TPA as a promoter. These results suggested that an extract of the roots of the Taraxacum plant could be a valuable chemopreventive agent against chemical carcinogenesis.
Kyoto Pharmaceutical University, Japan.
M
M
Takasaki
T
T
Konoshima
H
H
Tokuda
K
K
Masuda
Y
Y
Arai
K
K
Shiojima
H
H
Ageta
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000633:toxicity; D005260:Female; D037341:Fumonisins; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000517:prevention & control; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D002264:Carboxylic Acids; D037341:Fumonisins; D010936:Plant Extracts; C056933:fumonisin B1; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate