Multidrug resistance-associated protein subfamily transporters and drug resistance.
Multidrug resistance-associated protein gene MRP/MRP1, and its family genes, including MRP2/cMOAT, have been isolated and characterized. These ATP-binding cassette (ABC) superfamily transporter genes are differentially expressed in various normal tissues and multidrug-resistant cell lines. Transfection of MRP/MRP1 and MRP2/cMOAT cDNA confers drug resistance on different spectra of anticancer agents from that of MDR1 coding P-glycoprotein. Although it remains unclear how MRP/MRP1 and related family genes are specifically involved in drug resistance in clinical cancers, current knowledge of the MRP subfamily suggests the importance of this class of transporters as a molecular target for drug sensitivity to anticancer agents.
Kuwano
M
M
Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan.
Toh
S
S
Uchiumi
T
T
Takano
H
H
Kohno
K
K
Wada
M
M
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D027321:Anion Transport Proteins; D002352:Carrier Proteins / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics* / Q000502:physiology; D019450:Genes, MDR / Q000235:genetics* / Q000502:physiology; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins
D018528:ATP-Binding Cassette Transporters; D027321:Anion Transport Proteins; D002352:Carrier Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins