Nuclear organization of pre-mRNA splicing factors.
The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.
Sleeman
J E
JE
Department of Biochemistry, University of Dundee, Medical Sciences Institute/Wellcome Trust Building Complex, Dow Street, Dundee, DD1 5EH,UK.
Lamond
A I
AI
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D012326:RNA Splicing; D012342:RNA, Small Nuclear / Q000378:metabolism; D017381:Spliceosomes / Q000378:metabolism*
D012322:RNA Precursors; D012342:RNA, Small Nuclear