[Decreased serum level of free bioavailable IGF-I in patients with diabetic retinopathy].
BACKGROUND
Growth factors like IGF-I have been implicated in the pathogenesis of diabetic retinopathy. To investigate the role and bioavailability of IGF-I we measured not only total but also free serum levels of IGF-I in diabetic patients.


METHODS
A total of 159 patients with and without diabetic retinopathy were investigated (60 diabetic patients without and 99 with clinically and angiographically diagnosed diabetic retinopathy). One hundred ten healthy volunteers served as controls. The data were analyzed by Student's t-test, analysis of variance and correlation; P < 0.05 was considered statistically significant.


RESULTS
Diabetic patients with retinopathy showed significantly lower serum levels of free IGF-I than diabetics without retinopathy. Free IGF-I was negatively correlated with glycosylated hemoglobin 1c. IGFBP-3 levels were diminished in type 2 patients with diabetic retinopathy, while type 1 patients with diabetic retinopathy showed higher IGFBP-1 levels.


CONCLUSIONS
Diabetic patients with retinopathy showed significantly reduced serum levels of free IGF-I. Low IGF-I was associated with poor metabolic control.
Medizinische Klinik, Universität Ulm.
B
B
Feldmann
G E
GE
Lang
A
A
Arnavaz
P M
PM
Jehle
B O
BO
Böhm
G K
GK
Lang
D001682:Biological Availability; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values
D007334:Insulin-Like Growth Factor I
Verminderte Serumspiegel von freiem bioverfügbarem IGF-I bei Patienten mit diabetischer Retinopathie.