Development of a novel class of subtype-selective nicotinic receptor antagonist: pyridine-N-substituted nicotine analogs.
Dwoskin
L P
LP
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 40536-0082, USA. ldwoskin@pop.uky.edu
Wilkins
L H
LH
Pauly
J R
JR
Crooks
P A
PA
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001921:Brain / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D004079:Dihydro-beta-Erythroidine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D009538:Nicotine / Q000031:analogs & derivatives*; D018733:Nicotinic Antagonists / Q000737:chemistry* / Q000145:classification; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism*; D012413:Rubidium / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects
D018733:Nicotinic Antagonists; D011725:Pyridines; D011978:Receptors, Nicotinic; D004079:Dihydro-beta-Erythroidine; D009538:Nicotine; D012413:Rubidium; D004298:Dopamine