Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine.
Ajoene (CAS 92284-99-6), an organic trisulphur originally isolated from garlic, has an antimycotic activity which has been widely demonstrated both in vitro and in vivo. The objective of this work was to compare the safety and effectiveness of ajoene (0.6%, gel) with terbinafine (CAS 91161-71-6) (1%, cream) for the treatment of tinea corporis and tinea cruris. The patients selected were 60 soldiers with clinical and mycological diagnosis of either dermatophytosis. They were distributed at random in two treatment groups, one treated with ajoene at 0.6% and the other with terbinafine at 1%. All patients were evaluated clinically and mycologically 30 and 60 days after completion of the treatment, which was considered effective when clinical signs and symptoms had disappeared and the mycological cultures were negative. Thirty days after treatment, the percent healing rate was 77 and 75 for the groups treated with ajoene and terbinafine, respectively. Sixty days after treatment, the healing rate 73% and 71% for the groups treated with ajoene and terbinafine, respectively. These results and those obtained in previous studies confirm that ajoene is a new agent for the topic treatment of superficial mycoses, and for the first time show the therapeutic usefulness of an inhibitor of phospholipids biosynthesis in eukaryotes.
Centro de Investigationes en Ciencias de la Salud (CICS), Instituto de Investigación y Desarrollo Anzóategui, Escuela de Medicina, Universidad de Oriente, Núcleo Anzóategui, Puerto la Cruz, Venezuela. rapitz@ivic.ivic.ve
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Ledezma
J C
JC
López
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Marin
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Romero
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Ferrara
L
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De Sousa
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Jorquera
R
R
Apitz Castro
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004220:Disulfides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005782:Gels; D006801:Humans; D009281:Naphthalenes / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013454:Sulfoxides; D000077291:Terbinafine; D014005:Tinea / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D004220:Disulfides; D005782:Gels; D009281:Naphthalenes; D010936:Plant Extracts; D013454:Sulfoxides; C048980:ajoene; D000077291:Terbinafine