Bcl10 is not a target for frequent mutation in human carcinomas.
The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
A R
AR
Lambers
C
C
Gumbs
S
S
Ali
J R
JR
Marks
J D
JD
Iglehart
A
A
Berchuck
P A
PA
Futreal
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000074018:B-Cell CLL-Lymphoma 10 Protein; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D009363:Neoplasm Proteins