Cytomegalovirus (CMV) DNA load is an independent predictor of CMV disease and survival in advanced AIDS.
The impact of cytomegalovirus (CMV) on human immunodeficiency virus type 1 (HIV-1) disease progression has been controversial. In this study, we sought to determine if CMV viral load is independent of HIV-1 viral load in predicting CMV disease and survival. Our findings indicate that in patients with advanced AIDS, CMV DNA load is an independent marker of CMV disease and survival and is more predictive than HIV-1 RNA load. Moreover, patients who respond to preemptive therapy with oral ganciclovir, with resulting undetectable levels of CMV DNA, in their plasma, have a significantly lower risk of developing CMV disease and higher rates of survival, despite stable or increasing HIV-1 RNA loads. These data provide support for CMV as an independent risk factor for mortality in persons with advanced AIDS and further suggest that effective preemptive therapy for CMV can improve patient survival rates.
Department of Pediatrics, University of California, San Diego, La Jolla, California, USA. saspector@ucsd.edu
S A
SA
Spector
K
K
Hsia
M
M
Crager
M
M
Pilcher
S
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Cabral
M J
MJ
Stempien
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology / Q000821:virology*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003587:Cytomegalovirus / Q000235:genetics*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology / Q000821:virology*; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D017741:Survivors; D019562:Viral Load
D000998:Antiviral Agents; D004279:DNA, Viral; D012367:RNA, Viral; D015774:Ganciclovir