Comparative bone growth behavior in granules of bioceramic materials of various sizes.
Various bioceramic materials were implanted into 6-mm-diameter holes made in the femoral condyles of mature Japanese white rabbits using different-sized granules to find an optimal material and granule diameter for use as a bone graft. Bioceramics include a bioinert ceramic (Alumina), surface-bioactive ceramics [hydroxyapatite (HAp) and Bioglass(R)], and resorbable bioactive ceramics [alphatricalcium phosphate (alpha-TCP), beta-TCP, tetracalcium phosphate (TeCP), Te. DCPD, Te. DCPA, and low-crystalline HAp]. Granule sizes were 100-300, 10, and 1-3 microm. Bone growth behavior varied with the kind of bioceramic and the size used. For surface-bioactive ceramics, 45S5 Bioglass(R) led to more rapid bone proliferation than synthetic HAp. In resorbable bioactive ceramics, the order of resorption was: low-crystalline HAp and OCP > TeCP, Te DCPD, Te DCPA > alpha-TCP, beta-TCP. In terms of biocompatibility, alpha-TCP was better than beta-TCP.
Department of Orthopaedic Surgery, Artificial Joint Section and Biomaterial Research Laboratory, Osaka-Minami National Hospital, 677-2, Kido-Cho, Kawachinagano-Shi, Osaka 586, Japan.
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Oonishi
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Hench
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Wilson
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Sugihara
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Tsuji
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Kushitani
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Iwaki
D000537:Aluminum Oxide; D000818:Animals; D018786:Bone Substitutes; D001842:Bone and Bones / Q000166:cytology* / Q000648:ultrastructure; D002516:Ceramics; D017886:Durapatite; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis / Q000502:physiology*; D011817:Rabbits; D013499:Surface Properties
C022107:Bioglass; D018786:Bone Substitutes; D017886:Durapatite; D000537:Aluminum Oxide