[The role of an imbalance of sex and calcium-regulating hormones in osteoarthrosis deformans in women].
OBJECTIVE
Determination of essential changes in hormonal background in evaluation of sex and calcium-regulating hormones levels in women of different age with osteoarthrosis deformans (OAD).


METHODS
30-34-year-old and 45-60-year-old females (60 premenopausal and 51 menopausal) with x-ray confirmed OAD and 34 control healthy women (23 premenopausal and 11 in menopause) were examined with radioimmunoassay for the baseline serum levels of calcitonin, parathyrine, osteocalcin, estradiol, testosterone, progesterone, dehydroepiandrosterone-sulfate (DHAS).


RESULTS
Both age-groups patients had abnormal levels of testosterone and its metabolite DHAS. Significant deviations were found in menopausal women. With age, both patients and healthy women exhibited increasing levels of parathyrine and calcitonine. Compared to controls, OAD women had lower parathyrine, osteocalcine and higher calcitonine levels. With OAD progression, serum osteocalcin tended to lowering while testosterone was on the increase.


CONCLUSIONS
Changes in blood levels of calcium-regulating hormones observed in osteoarthrosis may result in stimulation of cartilage degeneration. Calcitonine was low in premenopausal and menopausal OAD patients indicating impairment of bone metabolism in osteoarthrosis.
N I
NI
Makarova
V A
VA
Bobkov
D000328:Adult; D002118:Calcium / Q000097:blood*; D002979:Climacteric / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood* / Q000209:etiology; D012016:Reference Values
D012739:Gonadal Steroid Hormones; D006728:Hormones; D002118:Calcium
O roli disbalansa polovykh i kal'tsiĭreguliruiushchikh gormonov pri deformiruiushchem osteoartroze u zhenshchin.