Manifestation of scotomas created by transcranial magnetic stimulation of human visual cortex.
Reduced visual performance under transcranial magnetic stimulation (TMS) of human visual cortex demonstrates suppression whose spatial extent is not directly visible. We created an artificial scotoma (region missing from a visual pattern) to directly visualize the location, size and shape of the TMS-induced suppression by following a large-field, patterned, visual stimulus with a magnetic pulse. The scotoma shifted with coil position according to known topography of visual cortex. Visual suppression resulted in pattern-dependent distortion, and the scotoma was filled in with temporally adjacent stimuli, suggesting spatial and temporal completion mechanisms. Thus, perceptual measurements of TMS-induced suppression may provide information about cortical processing via neuronal connections and temporal interactions of neural signals.
Kamitani
Y
Y
Computation and Neural Systems, California Institute of Technology, MC 139-74, Pasadena, California 91125, USA. kamitani@percipi.caltech.edu
Shimojo
S
S
D006801:Humans; D015225:Magnetoencephalography; D010775:Photic Stimulation; D012160:Retina / Q000528:radiation effects; D012607:Scotoma / Q000209:etiology*; D014793:Visual Cortex / Q000502:physiology*