Effect of botulinum toxin type A on movement-associated rhytides following CO2 laser resurfacing.
BACKGROUND
Many patients who undergo CO2 laser resurfacing for correction of rhytides experience recurrence of movement-associated wrinkles within 6 to 12 months following the laser procedure.


OBJECTIVE
The purpose of this study was to evaluate the effect of botulinum toxin type A (Botox) injections on movement-associated rhytides following cutaneous laser resurfacing.


METHODS
Forty patients who had received full face CO2 laser resurfacing for the treatment of facial rhytides were randomized to receive Botox injections to the glabella, forehead or lateral canthal regions or to receive no additional treatment (control group). Clinical and photographic assessments were performed at baseline and at 3, 6 and 9 months.


RESULTS
Enhanced and more prolonged correction of forehead, glabellar and/or lateral canthal rhytides was observed in patients treated with Botox injections postoperatively compared to non-Botox treated control patients.


CONCLUSIONS
The use of botulinum toxin type A following cutaneous CO2 laser resurfacing results in prolonged correction of movement-associated rhytides. It is advised that patients receive information regarding the benefits of maintenance therapy with botulinum toxin as part of their routine preoperative education.
Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
T B
TB
West
T S
TS
Alster
D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000494:pharmacology*; D002245:Carbon Dioxide; D005152:Facial Muscles / Q000187:drug effects*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D053685:Laser Therapy; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011184:Postoperative Period; D015361:Rhytidoplasty; D016896:Treatment Outcome
D009465:Neuromuscular Agents; D002245:Carbon Dioxide; D019274:Botulinum Toxins, Type A