The citrus flavonoid nobiletin suppresses the production and gene expression of matrix metalloproteinases-9/gelatinase B in rabbit synovial cells.
Ito
A
A
Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan. itoa@ps.toyaku.ac.jp
Ishiwa
J
J
Sato
T
T
Mimaki
Y
Y
Sashida
Y
Y
D000818:Animals; D002478:Cells, Cultured; D002957:Citrus; D017364:Collagenases / Q000096:biosynthesis / Q000235:genetics*; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology; D020780:Matrix Metalloproteinase 9; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D013329:Structure-Activity Relationship; D013583:Synovial Membrane / Q000201:enzymology*; D014158:Transcription, Genetic / Q000187:drug effects
D047309:Flavones; D005419:Flavonoids; D007375:Interleukin-1; D012333:RNA, Messenger; C008661:nobiletin; D017364:Collagenases; D020780:Matrix Metalloproteinase 9