The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke.
After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke.
Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
C K
CK
Chang
F Y
FY
Chueh
M T
MT
Hsieh
M T
MT
Lin
D000818:Animals; D001600:Berberine Alkaloids / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology; D018883:Heat Stroke / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D001600:Berberine Alkaloids; D018696:Neuroprotective Agents; C014215:tetrahydropalmatine