Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures.
Second- and third-generation cephalosporins, especially cefotetan, are increasingly associated with severe, sometimes fatal immune hemolytic anemia. We noticed that 10 of our 35 cases of cefotetan-induced hemolytic anemias were in patients who had received cefotetan prophylactically for obstetric and gynecologic procedures. Eight of these cases of severe immune hemolytic anemia are described.
American Red Cross Blood Services, Southern California Region, Los Angeles, California, USA.
G
G
Garratty
R M
RM
Leger
P A
PA
Arndt
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D015313:Cefotetan / Q000009:adverse effects*; D002513:Cephamycins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D013513:Obstetric Surgical Procedures; D011247:Pregnancy; D012720:Severity of Illness Index
D002513:Cephamycins; D015313:Cefotetan