20-hydroxyecdysone as a human lymphocyte and neutrophil modulator: In vitro evaluation.
20-hydroxyecdysone (1 microM) was found to activate in vitro T-cell CD2 presentation, which is suppressed both in secondary immunodeficient persons and pharmacologically by increasing intracellular cAMP levels. The compound was found to act like a synthetic psycho-immunomodulator 1-oxy-4-oxoadamantane (1 microM) and to exceed the effects of the thymomimetic agent levamisol (1 microM). In addition, 20-hydroxyecdysone (1 microM) was also revealed to modulate the fluoride-stimulated respiratory burst of human neutrophils in the same manner as water soluble antioxidants. Arch.
The Centre of Laboratory Diagnostics, Ekaterinburg, The Institute of Biology, Syktyvkar, Russia. aleks@uwc.ru
D S
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Trenin
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Volodin
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D018801:CD2 Antigens / Q000096:biosynthesis; D004441:Ecdysterone / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D018801:CD2 Antigens; D004441:Ecdysterone