Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old.
Neopterin and biopterin concentrations were measured in cerebrospinal fluid (CSF) and urine samples from controls less than 1 year old. This is the first time for CSF reference data for controls less than 1 year old to be reported. The ratio of neopterin to biopterin in CSF 0-30 days (n = 48) of age in control samples was 0.65 +/- 0.31 (SD), which was far lower than that in urine over the same time period, 4.0 +/- 1.9 (SD), (n = 51). This finding is very important when diagnosing 6-pyruvoyltetrahydropterin synthase (PTPS) deficiency and peripheral form of PTPS deficiency in the neonatal period. Our CSF reference data for controls should be useful in the diagnosis of PTPS deficiency.
Sawada
Y
Y
Department of Pediatrics, Osaka City University, Japan. sawada-y@cb3.so-net.ne.jp
Shintaku
H
H
Isshiki
G
G
D000367:Age Factors; D001708:Biopterins / Q000134:cerebrospinal fluid* / Q000652:urine; D016001:Confidence Intervals; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019798:Neopterin / Q000134:cerebrospinal fluid* / Q000652:urine; D012016:Reference Values
D001708:Biopterins; D019798:Neopterin