Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine allogeneic bone marrow transplantation model it was found that, despite the presence of numerous donor antigen-presenting cells, only host-derived antigen-presenting cells initiated graft versus host disease. Thus, strategies for preventing graft versus host disease could be developed that are based on inactivating host antigen-presenting cells. Such strategies could expand the safety and application of allogeneic bone marrow transplantation in treatment of common genetic and neoplastic diseases.
Shlomchik
W D
WD
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Couzens
M S
MS
Tang
C B
CB
McNiff
J
J
Robert
M E
ME
Liu
J
J
Shlomchik
M J
MJ
Emerson
S G
SG
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology / Q000517:prevention & control*; D006183:H-2 Antigens / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D015778:Minor Histocompatibility Antigens / Q000276:immunology; D013154:Spleen / Q000276:immunology; D018183:Transplantation Chimera
D006183:H-2 Antigens; D015778:Minor Histocompatibility Antigens