Thallium-201 single-photon emission computed tomographic and proton magnetic resonance spectroscopic characteristics of intracranial ganglioglioma: three technical case reports.
OBJECTIVE
The correlation between thallium-201 (201TI) uptake, semiquantitative choline-containing compound values measured by proton magnetic resonance spectroscopy (1H-MRS), and Ki-67 labeling indexes (LIs) was investigated in three gangliogliomas.


METHODS
The early and delayed 201TI indexes were calculated as the ratio of tumor to normal brain tissue uptake by 201TI single-photon emission computed tomography. Single-voxel 1H-MRS was performed to measure the levels of metabolites in the tumors. Ki-67 LI was measured in the surgical specimens.


RESULTS
All three gangliogliomas showed very high 201TI uptake on both early and delayed images. 1H-MRS demonstrated malignancy based on the high choline peak relative to the creatine and N-acetylaspartate peaks. Ki-67 LI was less than 1% in two gangliogliomas and 3.5% in an anaplastic ganglioglioma.


CONCLUSIONS
Both 201TI single-photon emission computed tomography and 1H-MRS indicated malignancy, whereas Ki-67 LI indicated low growth activity. 201TI single-photon emission computed tomography and 1H-MRS of ganglioglioma might be affected by metabolic characteristics other than growth activity.
Kumabe
T
T
Department of Neurosurgery, Tohoku University of School of Medicine, Sendai, Japan.
Shimizu
H
H
Sonoda
Y
Y
Shirane
R
R
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002455:Cell Division / Q000502:physiology; D002794:Choline / Q000032:analysis; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000601:surgery; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010296:Parietal Lobe / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D019394:Ki-67 Antigen; D013794:Thallium Radioisotopes; D002794:Choline