Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?
Sirotnak
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FM
D000630:Aminopterin / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002999:Clone Cells; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D011099:Polyglutamic Acid / Q000187:drug effects / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D011099:Polyglutamic Acid; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; C040210:edatrexate; D000630:Aminopterin