Laser skin resurfacing using a frequency doubled Nd:YAG laser after topical application of an exogenous chromophore.
OBJECTIVE
Although laser skin resurfacing performed with CO(2) or Er:YAG lasers is efficient, side effects such as prolonged postoperative erythema, delayed healing, scarring, and pigmentation, have been reported. These side effects are due to skin characteristics but also to variations of the thermal effects associated with laser skin resurfacing. The study aimed to evaluate a new laser resurfacing method based on a previous topical application of an exogenous chromophore in order to have reproducible thermal effects.


METHODS
Exogenous chromophore consisted in carbon dispersed and mixed with film-forming polymers and water. The resultant solution was applied to the skin surface using an airbrush. Experimental evaluation was performed in vivo on hairless rat skin using the following parameters (532 nm, 2.7 W, 1 mm, 50-200 ms, 17.2-68.8 J/cm(2), single pass). Skin biopsies were taken to evaluate histological changes and to quantify epidermis ablation and dermal coagulation depth. Wound healing was followed up during 10 days.


RESULTS
Total epidermis ablation was achieved with all pulse durations used. Dermal coagulation depth increased as a function of exposure time. Scar formation was correlated with dermal coagulation depth.


CONCLUSIONS
The concept of applying a carbon-based solution onto skin in order to obtain laser light conversion into heat followed by heat transfer to the tissue is valid for laser skin resurfacing. By selecting exposure time, the thermal effects are predictable and dermal coagulation depth can be either that observed with a Er:YAG laser or that obtained with a CO(2) laser. Moreover, frequency doubled Nd:YAG laser, already used in dermatology for angiodysplasias treatment, could be easily used for resurfacing of periorbital or perioral zones.
GALDERMA Research and Development, F-06902 Sophia Antipolis, France.
C C
CC
Sumian
F B
FB
Pitre
B E
BE
Gauthier
M
M
Bouclier
S R
SR
Mordon
D000287:Administration, Topical; D000818:Animals; D002244:Carbon / Q000008:administration & dosage*; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D011923:Rats, Nude; D019651:Plastic Surgery Procedures; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology*
D002244:Carbon