Paraneoplastic painful ulnar neuropathy.
A 58-year-old woman developed painful, bilateral ulnar neuropathy in conjunction with small cell lung carcinoma and high serum titer of anti-Hu antibody. An incidental stage I plasma cell dyscrasia, with immunoglobulin G kappa monoclonal protein, was also present. Electropysiological assessment excluded a generalized neuropathy, and nerve biopsy showed marked loss of myelinated and small unmyelinated fibers, without inflammatory changes or amyloid deposition. High titers of circulating anti-Hu antibody can be associated with symptoms resembling a paraneoplastic mononeuropathy.
Sharief
M K
MK
Department of Neurology, Guy's, King's and St. Thomas's Medical School, Guy's Hospital, London SE1 9RT, U.K.
Robinson
S F
SF
Ingram
D A
DA
Geddes
J F
JF
Swash
M
M
D000906:Antibodies / Q000097:blood*; D018288:Carcinoma, Small Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D008875:Middle Aged; D009431:Neural Conduction; D009437:Neuralgia / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D014459:Ulnar Nerve / Q000503:physiopathology*
D000906:Antibodies