Nonpeptidic ligands for peptide and protein receptors.
The first potent nonpeptidic ligands for somatostatin, luteinizing hormone-releasing hormone, glucagon and bradykinin receptors have been reported. Nonpeptidic clinical candidates have been identified or are currently under study for substance P, bradykinin, endothelin, growth hormone secretagogue, angiotensin, vasopressin, motilin and cholecystokinin. Design, screening, combinatorial chemistry and classical medicinal chemistry all played important roles in these advances.
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. roger_freidinger@merck.com
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D019204:GTP-Binding Proteins / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011485:Protein Binding
D008024:Ligands; D008565:Membrane Proteins; D010455:Peptides; D016179:Granulocyte Colony-Stimulating Factor; D019204:GTP-Binding Proteins