Antiphospholipid (Hughes') syndrome in African-Americans: IgA aCL and abeta2 glycoprotein-I is the most frequent isotype.
Antiphospholipid (Hughes') syndrome (APS) has not been reported in African-Americans (A-A) as frequently as in other ethnic groups. We describe eight A-A female patients with APS, including two cases of primary APS (PAPS), four with APS secondary to systemic lupus erythematosus (SLE), one with Sjögren's syndrome, and one with overlap connective tissue disease (CTD). Their mean age was 34 y (range 24-47 y). Patients were followed for a mean of 6 y (range 0.3-11 y). During follow up, both anticardiolipin (aCL) and anti-beta2glycoprotein-I (abeta2GPI) antibodies were measured in stored sera by enzyme-linked immunosorbent assay (ELISA). IgA was the most frequent isotype of aCL and abeta2GPI, and co-occurred with the IgM isotype in three of four patients with neurologic manifestations.
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112-2822, USA.
E
E
Diri
E
E
Cucurull
A E
AE
Gharavi
D
D
Kapoor
E A
EA
Mendez
E
E
Scopelitis
W A
WA
Wilson
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000208:ethnology* / Q000276:immunology*; D044383:Black People; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology / Q000276:immunology; D008875:Middle Aged; D053482:beta 2-Glycoprotein I; D001741:Black or African American
D017153:Antibodies, Anticardiolipin; D006023:Glycoproteins; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D053482:beta 2-Glycoprotein I