Endocytosis: Is dynamin a 'blue collar' or 'white collar' worker?
The GTPase dynamin clearly plays an important role in endocytosis, but precisely how has been controversial. Some recent results support the view that dynamin uses GTP hydrolysis physically to drive vesiculation; others support the view that dynamin acts as a classical G protein 'switch'. Perhaps both views are correct.
Yang
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Department of Molecular Medicine, Cornell University, Ithaca, New York 14850, USA.
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D000818:Animals; D004330:Drosophila; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D006868:Hydrolysis; D008954:Models, Biological; D015398:Signal Transduction; D015533:Transcriptional Activation
D020558:GTP Phosphohydrolases; D034281:Dynamins