Cytokines: from technology to therapeutics.
Cytokines are playing an ever-increasing role in the treatment of human disease. The characterization of these proteins plays a vital role in their development as useful therapeutic agents. Physicochemical techniques can produce information about the structure and composition of cytokine therapeutics but cannot yet predict their biological activity, for which biological assays are required. Because of the large number of techniques available and the variety of products requiring analysis, the tests used to characterize cytokine products must be both appropriate for the product and adequately controlled if the information they provide is to be of value.
Division of Immunobiology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, UK EN6 3QG. amire-sluis@nibsc.ac.uk
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D001681:Biological Assay; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D002627:Chemistry, Physical / Q000379:methods; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D007118:Immunoassay / Q000379:methods*
D016207:Cytokines