Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium.
A shared antigenic teichoic acid, previously found to be a surface capsule-like polysaccharide, was isolated from clinical isolates of Enterococcus faecalis and vancomycin-resistant E. faecium. It was composed of glucose, glycerol, and phosphate as determined by chemical and GC-MS analysis. The repeating-unit structure was elucidated by a series of 1H, 13C, and 31P NMR spectroscopy to be the following: [formula: see text]
Wang
Y
Y
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115-5804, USA. ywang@channing.harvard.edu
Huebner
J
J
Tzianabos
A O
AO
Martirosian
G
G
Kasper
D L
DL
Pier
G B
GB
D000942:Antigens, Bacterial / Q000737:chemistry*; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000737:chemistry* / Q000276:immunology; D016984:Enterococcus faecium / Q000737:chemistry* / Q000187:drug effects / Q000276:immunology; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D013682:Teichoic Acids / Q000737:chemistry*; D014640:Vancomycin / Q000494:pharmacology*
D000942:Antigens, Bacterial; D013682:Teichoic Acids; D014640:Vancomycin