IgM/IgA nephropathy in callitrichids: antigen studies.
Renal tissues of callitrichids with IgM nephropathy were immunohistochemically examined for the participation of IgA in pathogenesis. In 58 histopathologically nephropathy-positive kidneys, IgM predominated in 20 cases and IgA in 7 cases, and in 31 cases both immunoglobulins were rated to be approximately equally involved. The disease, therefore, might be described as IgM/IgA nephropathy. The renal tissues and sera were also tested for nutritional antigens or antinutritional antigen antibodies, using immunohistochemistry and Western blots (tissues) and enzyme-linked immunosorbent assay (sera). Evidences of nutritional antigens in the renal tissues were inconclusive, although circulating IgG class antibodies against cereals, milk, and egg proteins were present in quite a number of sera. Particular consideration was paid to IgA-antigliadin antibodies, which were statistically significantly associated with nephropathy as were IgA rheumatoid factors. The findings are discussed in relation to human IgA and IgM nephropathies.
Brack
M
M
German Primate Center, Göttingen, Germany.
Schroeder
C
C
Fooke
M
M
Schlumberger
W
W
D000818:Animals; D000941:Antigens / Q000276:immunology; D002143:Callitrichinae / Q000276:immunology*; D005502:Food; D005903:Gliadin / Q000097:blood / Q000276:immunology; D005920:Glomerular Mesangium / Q000276:immunology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D007150:Immunohistochemistry; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008992:Monkey Diseases / Q000473:pathology*; D012217:Rheumatoid Factor / Q000097:blood / Q000276:immunology
D000941:Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005903:Gliadin; D012217:Rheumatoid Factor