The antibacterial activity of plaunotol against Staphylococcus aureus isolated from the skin of patients with atopic dermatitis.
Plaunotol was tested for possible antibacterial activity against twenty strains of methicillin-resistant Staphylococcus aureus (MRSA) and fourteen strains of methicillin-sensitive S. aureus (MSSA) which had been isolated from the skin of patients with atopic dermatitis under growth-promoting conditions. Plaunotol was effective against all strains tested. The dose of plaunotol for 50% inhibition of growth (ID50) ranged from 2.5 to 16 micrograms/ml for strains of MRSA and from 2.5 to 7.0 micrograms/ml for those of MSSA. These results suggest that plaunotol may be useful in the prevention of infection by MRSA and in skin care for patients with atopic dermatitis.
Matsumoto
Y
Y
Department of Microbiology, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Hamashima
H
H
Masuda
K
K
Shiojima
K
K
Sasatsu
M
M
Arai
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003876:Dermatitis, Atopic / Q000382:microbiology*; D004224:Diterpenes; D004352:Drug Resistance, Microbial; D005233:Fatty Alcohols / Q000494:pharmacology*; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D012867:Skin / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D005233:Fatty Alcohols; C047686:plaunotol; D008712:Methicillin