Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients.
We examined the expression of cytokeratin 20 (CK20) mRNA in the peripheral blood of oral squamous cell carcinoma (SCC) patients by reverse transcriptase polymerase chain reaction (RT-PCR). Eleven out of 12 oral SCC patients showed positive RT-PCR results. However, there is no clear relationship between the haematogenous CK20 mRNA and the metastasis. After initial treatment, all of the tumour-free survivors tested showed negative RT-PCR results. CK20 mRNA in peripheral blood can be used as a marker for tumour recurrence but not not for metastasis in oral SCC patients.
Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan.
H
H
Kawamata
D
D
Uchida
K
K
Nakashiro
S
S
Hino
F
F
Omotehara
H
H
Yoshida
M
M
Sato
D014408:Biomarkers, Tumor / Q000097:blood*; D018196:Carcinoma, Adenosquamous / Q000097:blood / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000097:blood*; D053554:Keratin-20; D008297:Male; D009062:Mouth Neoplasms / Q000097:blood* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000473:pathology; D009360:Neoplastic Cells, Circulating / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; D053554:Keratin-20; D012333:RNA, Messenger