Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice.
DBA/2J mice repeatedly exposed to ethanol (2 g/kg, i.p. every 48 h for 8 days) exhibit sensitization to the locomotor stimulant effects of ethanol. Pretreatment with the NMDA receptor antagonist dizocilpine (0.2-0.3 mg/kg, i.p.) completely prevents the development of sensitization. Thus, NMDA receptors appear to play an important role in behavioural sensitization to ethanol.
Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health Sciences University, 97201-3098, USA.
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Broadbent
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Weitemier
D000704:Analysis of Variance; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006185:Habituation, Psychophysiologic; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D000431:Ethanol; D016291:Dizocilpine Maleate