Hyperimmunoglobulin E syndrome associated with nephrotic syndrome.
A 21-year-old man was admitted to Kure National Hospital with nephrotic syndrome in September 1996. He had suffered from an intractable pruritic skin rash and recurrent subcutaneous abscesses caused by the hyperimmunoglobulin E syndrome since the age of 18 months. Renal biopsy gave a diagnosis of membranoproliferative glomerulonephritis. Steroid therapy decreased urinary protein loss and hypoproteinemia, and his pruritic skin rash was improved. Patients with hyperimmunoglobulin E syndrome have a defective immune response, especially to Staphylococcus aureus infection. Continuous antigen stimulation may have caused this patient's renal histological damage as in immune complex glomerulonephritis.
Department of Internal Medicine, Kure National Hospital.
C
C
Tanji
N
N
Yorioka
K
K
Kanahara
T
T
Naito
H
H
Oda
K
K
Ishikawa
T
T
Taguchi
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D004109:Dilazep / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007589:Job Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D005938:Glucocorticoids; D014665:Vasodilator Agents; D014859:Warfarin; D011239:Prednisolone; D004109:Dilazep