Acute lymphoblastic leukemia.
This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classifications of ALL and criteria for establishing a diagnosis of ALL independent of morphology are described.
Department of Pathology and Laboratories, Miami Children's Hospital, Florida, USA. steve.melnick@mch.com
S J
SJ
Melnick
D002648:Child; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D016130:Immunophenotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000276:immunology; D011379:Prognosis