Primary squamous cell carcinoma in a patient with vaginal agenesis.
BACKGROUND
The development of a carcinoma in a neovagina constructed in patients with congenital vaginal agenesis is rare.


METHODS
To our knowledge, this is the first report of a squamous cell carcinoma developing in a neovagina that had been constructed by a simple cleavage technique without tissue transplantation. The latency period between reconstruction and tumor diagnosis was 20 years, during which the patient regularly used a prosthesis. The most important observation during this time was the repeated formation of granulation tissue and chronic inflammatory pseudopolyps in the neovagina, which were removed by cauterization. Despite pre- and intraoperative irradiation and radical surgery followed by chemotherapy, the prognosis is poor.


CONCLUSIONS
Patients with neovaginas, whatever the construction technique, need to be followed up regularly, as mechanical irritation from a prosthesis can add to other cancer risk factors, such as viral infection. Furthermore, the absence of transplanted tissue does not seem to protect from the risk.
Department of Surgical Oncology, Centre Hospitalo-Universitaire Lyon-Sud, Pierre-Bénite Cedex, 69495, France.
J Y
JY
Bobin
C
C
Zinzindohoue
T
T
Naba
S
S
Isaac
G
G
Mage
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D005260:Female; D006801:Humans; D011183:Postoperative Complications / Q000628:therapy*; D014621:Vagina / Q000002:abnormalities* / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000628:therapy*