Effects of pesticide exposure on time to pregnancy: results of a multicenter study in France and Denmark. ASCLEPIOS Study Group.
The aim of this study was to determine whether there was a relation between male exposure to pesticides and the amount of time needed to conceive (time to pregnancy) for farmers and agricultural workers in France and Denmark. The authors used retrospective studies to compare the time to pregnancy of couples in which the man was exposed to pesticides during the year before the birth of their youngest child with that of couples in which the man was not exposed. In 1995 and 1996, the authors studied 362 French rural workers (142 exposed to pesticides and 220 not exposed), 449 Danish farmers (326 conventional farmers exposed to pesticides and 123 nonexposed organic farmers), and 121 Danish greenhouse workers exposed to pesticides. The fecundability ratio for exposure to pesticides (Cox model, before and after adjustment for confounding factors) did not differ from 1 in any of the three populations. In France, the adjusted fecundability ratio was 1.17 (95% confidence interval (CI) 0.89-1.55) for exposed and nonexposed agricultural workers. In Denmark, it was 1.09 (95% CI 0.82-1.43) for exposed and nonexposed farmers and 0.83 (95% CI 0.69-1.18) for greenhouse workers and nonexposed farmers. Thus, this study found no relation between fertility (time to pregnancy) and male exposure to pesticides.
Institut National de la Santé et de la Recherche Médicale, Unité 292, Bicêtre Hospital, Le Kremlin-Bicêtre, France.
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P
Thonneau
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A
Abell
S B
SB
Larsen
J P
JP
Bonde
M
M
Joffe
A
A
Clavert
B
B
Ducot
L
L
Multigner
G
G
Danscher
D000328:Adult; D000382:Agricultural Workers' Diseases / Q000139:chemically induced*; D003718:Denmark; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D005602:France; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D018812:Paternal Exposure / Q000009:adverse effects*; D018579:Patient Selection; D010575:Pesticides / Q000009:adverse effects*; D011247:Pregnancy; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors
D010575:Pesticides