Identification of the TIMP-2 binding site on the gelatinase A hemopexin C-domain by site-directed mutagenesis and the yeast two-hybrid system.
Overall
C M
CM
Faculty of Dentistry, University of British Columbia, Vancouver, Canada. overall@interchange.ubc.ca
King
A E
AE
Bigg
H F
HF
McQuibban
A
A
Atherstone
J
J
Sam
D K
DK
Ong
A D
AD
Lau
T T
TT
Wallon
U M
UM
DeClerck
Y A
YA
Tam
E
E
D000595:Amino Acid Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D018093:Gelatinases / Q000737:chemistry* / Q000378:metabolism*; D006466:Hemopexin / Q000737:chemistry*; D006801:Humans; D007700:Kinetics; D020778:Matrix Metalloproteinase 2; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism*
D011994:Recombinant Proteins; D019716:Tissue Inhibitor of Metalloproteinase-2; D006466:Hemopexin; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2