Association of the NAD(P)H:quinone oxidoreductase 609C-->T polymorphism with a decreased lung cancer risk.
The NAD(P)H:quinone oxidoreductase gene, NQO1, often carries a C-->T transition at bp 609, which has been associated with a reduced enzymatic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens. We tested the association of this polymorphism with lung cancer risk in a population-based case-control study of 327 cases and 440 controls of Caucasian, Japanese, or Native Hawaiian ancestry in Hawaii. We found a notable difference in the frequency of the variant allele among Japanese (38%), Caucasians (20%), and Hawaiians (22%). Overall, the variant allele was less frequent in cases than in controls (P = 0.03). A significant inverse association was found in Japanese, with adjusted odds ratios of 0.8 (95% confidence interval, 0.4-1.5) and 0.3 (0.1-0.7) for the heterozygous and homozygous variant genotypes, respectively, compared with the homozygous wild-type genotype (P for genetic trend, 0.02). The association did not reach statistical significance in Caucasians and Hawaiians but was in the same direction.
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA.
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Chen
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D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003596:Cytosine; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000208:ethnology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D016017:Odds Ratio; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013941:Thymine; D044465:White People / Q000235:genetics
D003596:Cytosine; D016660:NAD(P)H Dehydrogenase (Quinone); D013941:Thymine