Recent advances in applied and mechanistic aspects of the enzymatic hydroxylation of steroids by whole-cell biocatalysts.
Recent advances in microbial steroid hydroxylation are covered, including new biocatalysts and substrate groups and new methodologies such as the use of low-water systems, immobilised biocatalysts, genetically constructed biocatalysts and enzyme mimics. Mechanistic factors that control the regiochemistry and stereochemistry of steroid hydroxylation are also discussed.
Department of Chemistry, Brock University, St. Catharines, ON, Canada. holland@chemiris.labs.brocku.ca
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D002384:Catalysis; D006900:Hydroxylation; D013250:Steroid Hydroxylases / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism*
D013256:Steroids; D013250:Steroid Hydroxylases