Free radicals and reactive oxygen species in programmed cell death.
Oxidative stress, originating from reactive oxygen species and free radicals provides a constant challenge to eukaryotic cell survival. While implicated in a number of degenerative diseases, some associated with aging and with aging itself, the manner and extent to which oxidative stress contributes to the initiation or implementation of programmed-cell death is problematic. If oxidative stress is an important modulator of programmed-cell death, any ability intentionally to augment or inhibit it might ameliorate diseases in which the process is abnormally underactive or overactive.
Anderson
K M
KM
Department of Medicine, Rush Presbyterian St Luke's Medical Center, Chicago, IL 60612, USA.
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Harris
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D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D002908:Chronic Disease; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000502:physiology*
D005609:Free Radicals; D017382:Reactive Oxygen Species