Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice.
Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P < 0.05) decreases in liver GSH and GSSG contents (15-37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P < 0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19-59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats.
MD-68, Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
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Ahmad
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Anderson
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Kitchin
D000818:Animals; D002101:Cacodylic Acid / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003433:Crosses, Genetic; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004249:DNA Damage; D005260:Female; D005978:Glutathione / Q000378:metabolism; D019803:Glutathione Disulfide / Q000378:metabolism; D006540:Herbicides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009955:Ornithine Decarboxylase / Q000378:metabolism; D065108:Ornithine Decarboxylase Inhibitors; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats
D002273:Carcinogens; D006540:Herbicides; D065108:Ornithine Decarboxylase Inhibitors; D003577:Cytochrome P-450 Enzyme System; D002101:Cacodylic Acid; D009955:Ornithine Decarboxylase; D005978:Glutathione; D019803:Glutathione Disulfide