Mixed base of hydrophilic ointment and purified lanolin to improve the drug release rate and absorption of water of minocycline hydrochloride ointment for treatment of bedsores.
A desired ointment bases for better treatment of bedsores was developed to improve the release rate of minocycline hydrochloride (MH) and the water absorption capacity using various types of hydrophobic to hydrophilic ointment base. The influence of purified lanolin (PL) on the release behavior of MH from hydrophilic ointment (HO) base was primarily focused on. It was found that the release rate of drug increased with increase in the hydrophilicity of the base. A linear correlation between the apparent release rate constant of drug from the HO and PL mixed ointment base at various combination ratios and the elution of ointment base was noted. The HO ointment base containing 30% PL had the highest apparent release rate constant of MH. The mixed ointment base with the lowest viscosity showed the highest absorption of water and elution of ointment base. In conclusion, it was found that HO (70%) and PL (30%) mixed ointment base was a promising candidate for better treatment of bedsores.
Department of Pharmacy, Takayama Red Cross Hospital, Gifu, Japan.
M
M
Shigeyama
T
T
Ohgaya
Y
Y
Kawashima
H
H
Takeuchi
T
T
Hino
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004058:Diffusion; D007809:Lanolin; D008911:Minocycline / Q000008:administration & dosage* / Q000627:therapeutic use; D009823:Ointment Bases; D009824:Ointments; D003668:Pressure Ulcer / Q000188:drug therapy*; D012869:Skin Absorption / Q000187:drug effects; D014783:Viscosity
D000900:Anti-Bacterial Agents; D009823:Ointment Bases; D009824:Ointments; D007809:Lanolin; D008911:Minocycline