Synthesis and potential muscarinic receptor binding and antioxidant properties of 3-(thiadiazolyl)pyridine 1-oxide compounds.
The synthesis of two different series of 3-(thiadiazolyl)pyridine 1-oxide containing 1,2,5- and 1,2,4-thiadiazole moiety respectively is described. The potential muscarinic receptor binding together with the antioxidant properties of the new compounds were evaluated.
Martinez
A
A
Instituto de Química Médica (CSIC), Madrid, Spain.
Alonso
D
D
Castro
A
A
Arán
V J
VJ
Cardelús
I
I
Baños
J E
JE
Badia
A
A
D000544:Alzheimer Disease / Q000188:drug therapy*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D018721:Muscarinic Agonists / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D000975:Antioxidants; D018721:Muscarinic Agonists; D011976:Receptors, Muscarinic; D013830:Thiadiazoles