Evaluation of the destructive effect of khaya gum on Bacillus subtilis spores during tableting.
The destructive effect of khaya gum used as a binding agent in a paracetamol formulation on Bacillus subtilis spores during tableting has been investigated, in comparison with the effects of two standard binders-polyvinylpyrrolidone and gelatin. The destructive effect of khaya gum was generally similar to those of the standard binders. Significant (p < 0.001 in each case) inverse linear relationships of log % survival of the B. subtilis spores with compression pressure and with concentration of binder, were established. The effect of the binding agent was significantly dependent (p < 0.001 in each case) on both compression pressure and the binder concentration. However, there was no significant interaction (p > 0.05) between the destructive effects of compression pressure and binder concentration. The results suggest that khaya gum and the standard binders would be useful in the destruction of microorganisms during tableting.
Odeku
O A
OA
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, College of Medicine, University of Ibadan, Nigeria.
Itiola
O A
OA
Odelola
H A
HA
D001412:Bacillus subtilis / Q000502:physiology*; D005069:Evaluation Studies as Topic; D005079:Excipients; D013171:Spores, Bacterial / Q000187:drug effects*; D013607:Tablets; D014197:Trees / Q000737:chemistry
D005079:Excipients; D013607:Tablets