Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus.
The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophiobolins were isolated from the extracts of the fungus Cochliobolus heterostrophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydration and dimerization products. Ophiobolin A (2) showed potent activity in cytotoxicity assays and marginal activity in antimalarial assays.
Shen
X
X
Department of Pharmacognosy, National Center for the Development of Natural Products, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Krasnoff
S B
SB
Lu
S W
SW
Dunbar
C D
CD
O'Neal
J
J
Turgeon
B G
BG
Yoder
O C
OC
Gibson
D M
DM
Hamann
M T
MT
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
C120732:3-anhydroophiobolin B; D000903:Antibiotics, Antineoplastic; D000962:Antimalarials; D001643:Bridged Bicyclo Compounds