Visualization of magnetoencephalographic data using minimum current estimates.
The locations of active brain areas can be estimated from the magnetic field the neural current sources produce. In this work we study a visualization method of magnetoencephalographic data that is based on minimum[symbol: see text] (1)-norm estimates. The method can represent several local or distributed sources and does not need explicit a priori information. We evaluated the performance of the method using simulation studies. In a situation resembling typical magnetoencephalographic measurement, the mean estimated source strength exceeded baseline level up to 2 cm from the simulated point-like source. The method can also visualize several sources, activated simultaneously or in a sequence, which we demonstrated by analyzing magnetic responses associated with sensory stimulation and a picture naming task.
Brain Research Unit, Low Temperature Laboratory, Espoo, FIN-02015 HUT, Finland.
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Uutela
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Hämäläinen
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E
Somersalo
D000465:Algorithms; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D001931:Brain Mapping / Q000295:instrumentation; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D016014:Linear Models; D015225:Magnetoencephalography / Q000295:instrumentation* / Q000706:statistics & numerical data; D012016:Reference Values