Effect of cytotoxic chemotherapy on serum lipid levels in breast cancer patients.
Seventy patients with breast cancer at various clinical stages and 15 patients with fibroadenoma were investigated. After chemotherapy, a significant increase in total triglycerides in malignant breast cancer patients before and after menopause has been observed. The increase in total cholesterol was not significant after chemotherapy. The levels of LDL and HDL cholesterol were significantly decreased in pre- and postmenopausal women treated with chemotherapy.
Department of Human Genetics AM, Lublin, Poland. jolarzym@servus.servodata.lublin.pi
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Rzymowska
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000097:blood*; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009367:Neoplasm Staging; D017698:Postmenopause; D017697:Premenopause; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D003520:Cyclophosphamide; D002784:Cholesterol; D005472:Fluorouracil; D008727:Methotrexate