Anti-inflammatory stent coatings: dexamethasone and related compounds.
The dexamethasone-eluting stent was a well-tolerated and effective means of providing sustained site-specific drug delivery to the porcine coronary artery wall for 28 days, although longer-term biocompatibility of the polymer coating was not assessed. Dexamethasone did not reduce the neointimal hyperplastic response to injury, despite sustained tissue levels of drug.
Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA.
S H
SH
Park
A M
AM
Lincoff
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible; D003327:Coronary Disease / Q000473:pathology / Q000628:therapy; D003331:Coronary Vessels / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D006965:Hyperplasia; D011474:Prosthesis Design; D055502:Secondary Prevention; D015607:Stents; D013552:Swine
D000893:Anti-Inflammatory Agents; D020099:Coated Materials, Biocompatible; D003907:Dexamethasone