Anticancer drug design based on plant-derived natural products.
This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis. Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.
Lee
K H
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Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill, Nc 27599-7360, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives; D003078:Colchicine / Q000031:analogs & derivatives; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005047:Etoposide / Q000031:analogs & derivatives / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D010944:Plants / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D050257:Tubulin Modulators
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D005419:Flavonoids; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D050257:Tubulin Modulators; D005047:Etoposide; D003078:Colchicine; D002166:Camptothecin