Regulation of back-propagating action potentials in hippocampal neurons.
Protein kinase C has recently been shown to modulate the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Moreover, dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase. The electrical signalling ability of these dendrites is thus highly regulated by a number of neurotransmitters and second-messenger systems.
Division of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030-3498, USA. dan@mossy.bcm.tmc.edu
D
D
Johnston
D A
DA
Hoffman
C M
CM
Colbert
J C
JC
Magee
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology*; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*