Paraneoplastic neurological disorders.
Distinct syndromes are associated with a limited range of tumours. Autoantibodies are provoked by tumour (onconeural) antigens. Paraneoplastic antibodies to ion channels (VGCC, VGKC, AChR) are disease-inducing, but may also slow tumour growth in the case of LEMS. Antibodies to intracellular antigens in CNS disorders are probably not disease-inducing, but are valuable in diagnosis as disease markers. T cell mediated cytotoxicity is the likely effector mechanism in these latter disorders.
Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford.
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Newsom-Davis
D000912:Antibodies, Neoplasm / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D011379:Prognosis; D013577:Syndrome
D000912:Antibodies, Neoplasm; D001323:Autoantibodies