ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.
ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library. In this study, we created transgenic mice overexpressing ICSAT in lymphocytes. Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT. ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.
Department of Hematology and Oncology, Graduate School of Medicine, Universiy of Tokyo, Tokyo, 113-8655, Japan.
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Saito
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Yamagata
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Takahashi
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Honda
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Hirai
D000328:Adult; D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D050835:Interferon Regulatory Factors; D007376:Interleukin-2 / Q000096:biosynthesis; D015458:Leukemia, T-Cell / Q000235:genetics*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009101:Multiple Myeloma / Q000235:genetics*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*; D000099218:Interferon Regulatory Factor-4
D003208:Concanavalin A; D004268:DNA-Binding Proteins; D007074:Immunoglobulin G; D050835:Interferon Regulatory Factors; D007376:Interleukin-2; D014157:Transcription Factors; D000099218:Interferon Regulatory Factor-4