3-Amino- and 5-aminopyrazoles with anticonvulsant activity.
New 3-amino- and 5-aminopyrazoles were synthesised. 3-Aminopyrazoles exert a strong anticonvulsant effect, 4-Chlorophenyl-3-(morpholin-4-yl)-1 H-pyrazole 2 distinctively blocks sodium channels and is strongly effective in the Maximal Electroshock Seizure (MES) test.
Corporate Research and Development ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Radebeul, Germany.
H J
HJ
Lankau
M
M
Menzer
A
A
Rostock
T
T
Arnold
C
C
Rundfeldt
K
K
Unverferth
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002460:Cell Line; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D011720:Pyrazoles; D015222:Sodium Channels