Telomeric (TTAGGG)n sequences are associated with nucleolus organizer regions (NORs) in the wood lemming.
The distribution of the (TTAGGG)n telomeric sequence was studied in chromosomes of the wood lemming, Myopus schisticolor, by fluorescence in-situ hybridization. As expected, the hybridization signals were observed at telomeres of all chromosomes. However, quite a number of interstitial telomeric sites were present in the pericentric heterochromatic regions. Consistent strong hybridization signals were also seen at one terminus of chromosomes 5, 7 and 12--15. By post-hybridization G-banding and silver-staining, the large blocks of the telomeric sequences on chromosomes 5 and 12 were localized to nucleolus organizer regions (NORs).
Liu
W S
WS
Department of Conservation Biology and Genetics, Uppsala University, Uppsala Genetic Centre, Sweden. wansheng.liu@genetik.uu.se
Fredga
K
K
D000818:Animals; D003411:Arvicolinae / Q000235:genetics*; D001483:Base Sequence; D002871:Chromosome Banding; D017404:In Situ Hybridization, Fluorescence; D009697:Nucleolus Organizer Region / Q000235:genetics*; D016615:Telomere / Q000235:genetics*