MMP inhibition reduces intimal hyperplasia in a human vein graft stenosis model.
Loftus
I M
IM
Department of Surgery, Leicester University, UK. ianloftus@aol.com
Porter
K
K
Peterson
M
M
Boyle
J
J
London
N J
NJ
Bell
P R
PR
Thompson
M M
MM
D017364:Collagenases / Q000378:metabolism*; D004318:Doxycycline / Q000494:pharmacology*; D018093:Gelatinases / Q000378:metabolism*; D006083:Graft Occlusion, Vascular / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology*; D006965:Hyperplasia; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008955:Models, Cardiovascular; D009924:Organ Culture Techniques; D011480:Protease Inhibitors / Q000494:pharmacology*; D012501:Saphenous Vein / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D017539:Tunica Intima / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
D006877:Hydroxamic Acids; D011480:Protease Inhibitors; C100342:marimastat; D017364:Collagenases; D018093:Gelatinases; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D004318:Doxycycline