[Energy-dependent changes in the ultrastructure of human cardiomyocyte mitochondria in alcoholic heart disease].
It is shown for the first time that energy dependent alterations of mitochondrial ultrastructure, well studied in vitro, can be demonstrated in vivo in human cardiomyocytes on the material of endomyocardial biopsies of the left ventricles taken from patients with alcoholic heart disease. Mitochondria in cardiomyocytes of these patients were in four energy dependent ultrastructural states: orthodoxal, energized, energized-twisted, deenergized. These alterations are interpreted as resulting from mitochondrial energetic disturbance in alcoholic heart disease.
A. N. Belozersky Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University.
Iu V
IuV
Sudarikova
L E
LE
Bakeeva
V G
VG
Tsyplenkova
D000328:Adult; D001706:Biopsy; D002310:Cardiomyopathy, Alcoholic / Q000378:metabolism / Q000473:pathology*; D004734:Energy Metabolism / Q000502:physiology*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000378:metabolism / Q000648:ultrastructure*
Energozavisimiye izmeneniia ul'trastruktury mitokhondriĭ kardiomiotsitov cheloveka pri alkogol'nom porazheni serdtsa.