Gender specific alterations of body composition in patients with inflammatory bowel disease compared with controls.
OBJECTIVE
To assess body hydration and the distribution of the body water compartments in defined populations of patients with inflammatory bowel disease (IBD) compared with those of matched healthy controls.


METHODS
Fifty-two patients with IBD at time of diagnosis (20 patients with Crohn's disease (CD-new) and 32 patients with ulcerative colitis (UC-new)), 40 patients with long-standing CD (CD-long) and 2 matched healthy control groups (n = 52 and n = 40) were recruited for the study.


METHODS
Total body water (TBW) and extracellular water (ECW) were measured by deuterium oxide and bromide dilution, respectively. Intracellular water (ICW) was calculated as TBW-ECW. In addition, hydration of fat-free mass (FFM) and the ECW:ICW ratio were calculated. FFM, body fat (BF) and % body fat (%BF) were assessed by dual energy X-ray absorptiometry.


RESULTS
In female IBD patients, the ECW:ICW ratio was significantly (P < 0.05) higher than in controls (CD-new: 0.89+/-0.11 vs 0.79+/-0.08, P < 0.01; UC-new: 0.85+/-0.15 vs 0.77+/-0.10, P < 0.05; CD-long: 0.86+/-0.14 vs 0.80+/-0.10, P < 0.05). In these female patients, the ICW:FFM ratio was significantly (P < 0.05) lower than in controls. Fluid shifts were especially pronounced in female patients with recently diagnosed CD. In male patients with recently diagnosed UC and in those with long-standing CD, body weight, body mass index, BF and %BF were significantly (P < 0.05) lower than in controls. No differences in body hydration or body water distribution were observed between male patients and controls.


CONCLUSIONS
An altered body water distribution and body hydration was observed in female IBD patients, especially in female patients with recently diagnosed CD.
Dept. of Gastroenterology and Hepatology, Maastricht, The Netherlands.
B J
BJ
Geerling
W D
WD
Lichtenbelt
R W
RW
Stockbrügger
R J
RJ
Brummer
D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition; D001834:Body Water; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000145:classification / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012727:Sex Characteristics