[Diabetic nephropathy: risk factors of rapid progression of renal failure].
OBJECTIVE
To reveal factors accelerating development of chronic renal failure (CRF) in patients with insulin-dependent diabetes mellitus type I (DM-I).


METHODS
A retrospective analysis of case histories was made for 40 patients with DM-I exhibiting progression of proteinuric stage of diabetic nephropathy prior to CRF stage. Clinical-laboratory indices were compared for patients with slow (group 1, n = 17) and fast (group 2, n = 23) development of CRF.


RESULTS
Patients of group 2 had significantly higher levels of glycosylated hemoglobin, total cholesterol, triglycerides in the blood, urine protein excretion, systolic and diastolic blood pressure than patients of group 1. Also, patients of group 2 had not taken antihypertensive drugs regularly.


CONCLUSIONS
Factors of risk of CRF early development of DM-I patients comprise unsatisfactory compensation of carbohydrate metabolism, hyperlipidemia, high proteinuria, arterial hypertension and inadequate antihypertensive therapy.
Shestakova
M V
MV
Chugunova
L A
LA
Shamkhalova
M Sh
MSh
Dirochka
Iu A
IuA
Dedov
I I
II
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000652:urine; D003928:Diabetic Nephropathies / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D006977:Hypertension, Renal / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000097:blood / Q000150:complications / Q000652:urine; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D002784:Cholesterol; D003404:Creatinine; D006442:Glycated Hemoglobin; D014280:Triglycerides
Diabeticheskaia nefropatiia: faktory riska bystrogo progressirovaniia pochechnoĭ nedostatochnosti.