Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.
The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentration and elimination half life were significantly increased and t-max was significantly reduced, indicating the suppression of phenytoin metabolism by 'Mentat'.
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.
S K
SK
Garg
A S
AS
Islam
N
N
Kumar
M
M
Sehgal
V K
VK
Bhargava
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits
D000927:Anticonvulsants; C074754:Mentat; D010936:Plant Extracts; D011619:Psychotropic Drugs; D010672:Phenytoin