Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis.
Amphotericin B has been the standard treatment for deep mycoses including African histoplasmosis, but its use is complicated by its toxicity. More recently, Fluconazole, a water-soluble triazole with antimycotic activity and little side effects, has become available. A case of African histoplasmosis from Nigeria, manifesting as multiple osteomyelitis and successfully treated with oral Fluconazole, is presented. Fluconazole may be preferred in the therapy of African histoplasmosis.
Onwuasoigwe
O
O
Department of Surgery, University of Nigeria Teaching Hospital, Enugu.
D000284:Administration, Oral; D000935:Antifungal Agents / Q000737:chemistry / Q000627:therapeutic use*; D002648:Child; D015725:Fluconazole / Q000737:chemistry / Q000627:therapeutic use*; D006660:Histoplasmosis / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009549:Nigeria; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000382:microbiology*; D018579:Patient Selection; D011859:Radiography
D000935:Antifungal Agents; D015725:Fluconazole