Tetrin C, a new glycosylated polyene macrolide antibiotic produced by Streptomyces sp. GK9244.
A new antifungal 26-membered polyene macrolide, tetrin C (1), has been isolated from Streptomyces sp. GK9244. Its structure has been determined by interpretation of NMR data. Compound 1 exhibited antifungal activity against Mortierella ramannianus (MIC, 5 microg/mL).
Korea Ginseng & Tobacco Research Institute, 302 Shinsung-dong Yousung-ku, Taejon, 305-345, Korea.
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G
Ryu
W C
WC
Choi
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Hwang
W H
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Yeo
C S
CS
Lee
S K
SK
Kim
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000187:drug effects; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C120737:tetrin C