Dependence of cardiac strength-interval curves on pacing rate.
The purpose of the research is to determine how the pacing rate affects the strength-interval curve in cardiac tissue. Computer simulations are used to calculate the cathodal and anodal strength-interval curves. The tissue is represented by the bidomain model with Beeler-Reuter membrane properties. The strength-interval curves shift to shorter intervals as the pacing rate increases. However, the shape of the strength-interval curve, including the separation into 'make' and 'break' sections and the presence of a 'dip', is insensitive to pacing rate.
Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 37235, USA.
J A
JA
Bennett
B J
BJ
Roth
D000200:Action Potentials; D002304:Cardiac Pacing, Artificial; D006321:Heart / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular