Isolation and identification of compounds with antinociceptive action from Ipomoea pes-caprae (L.) R. Br.
This study describes the isolation and identification of several constituents from Ipomoea pes-caprae (L.) R. Br., a medicinal plant frequently employed in folk medicine of many countries as a remedy against several diseases, including inflammation and pain. Our results demonstrate that some of these compounds, such as glochidone, betulinic acid, alpha- and beta-amyrin acetate, isoquercitrin, etc. showed pronounced antinociceptive properties in the writhing test and formalin test in mice. These data confirm our previous work concerning the antinociceptive action of the hydroalcoholic extract of I. pes-caprae and justify, at least in part, the popular use of this plant for the treatment of dolorous processes.
Krogh
R
R
Departamento de Química, Universidadade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
Kroth
R
R
Berti
C
C
Madeira
A O
AO
Souza
M M
MM
Cechinel-Filho
V
V
Delle-Monache
F
F
Yunes
R A
RA
D000009:Abdominal Muscles / Q000187:drug effects; D019342:Acetic Acid; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D019657:Solanaceae / Q000737:chemistry*
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid