Antimicrobial activity and stability of tingenone derivatives.
Quinone-methide triterpenes of the tingenone series were evaluated for their antimicrobial activity. These compounds were effective against Bacillus cereus, B. subtilis, Sarcina lutea, Staphylococcus aureus, Microsporum gypseum and a Gram-negative bacterium, Klebsiella pneumoniae. Under acidic conditions, the quinone-methide part of these compounds rearranged into the divinyl-phenolic system, and the antimicrobial activity was thus lost.
Sotanaphun
U
U
Lipipun
V
V
Suttisri
R
R
Bavovada
R
R
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001409:Bacillus cereus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D012505:Sarcina / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D014315:Triterpenes; C009492:tingenone; D053978:Pentacyclic Triterpenes