Ileal and colonic contractions by endothelin-1 in experimentally induced paralytic ileus in rats.
The aim of the present study was to investigate the effect of endothelin-1 on the isolated distal ileum and proximal colon in an experimentally induced ileus in rats. Ileal and colonic contractions by endothelin-1, acetylcholine alone and with endothelin-1 were recorded both in normal and experimentally induced paralytic ileus in rats. In the control group, all the responses to acetylcholine were found to be potentiated significantly when used together with endothelin-1 but in paralytic ileus group, no detectable change was observed in the responses of the amine after administration of acetylcholine together with endothelin-1. This study indicates that endothelin-1 might have an effect on gastrointestinal motility and postoperative paralytic ileus.
Department of General Surgery, Gazi University Medical Faculty, Ankara, Turkey.
E
E
Tekin
F
F
Taneri
E
E
Ersoy
S
S
Bozkurt
R
R
Yavuzer
S
S
Ercan
M
M
Oguz
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000503:physiopathology; D004357:Drug Synergism; D019332:Endothelin-1 / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology
D019332:Endothelin-1; D014665:Vasodilator Agents; D000109:Acetylcholine