Morphology and function of human benign tumors and normal thyroid tissues maintained in severe combined immunodeficient mice.
In the improved SCID (severe combined immunodeficient) mice, various human benign tumors of the head and neck region were well maintained morphologically and functionally for 3 years until the experiments were terminated, e.g. transplanted parathyroid adenoma secreted parathyroid hormone (PTH) in the SCID mice for more than 1 year. Normal human thyroid tissue was also well maintained in the SCID mice for 3 years. Rapid and high uptake of radioiodine into the transplanted human thyroid tissue was observed. Furthermore, transplanted human thyroid tissue secreted thyroid hormone (T3) and T3 secretion was stimulated by the injection of human thyroid stimulating hormone (TSH). These findings suggest that the improved SCID mice will provide an invaluable experimental system for investigating the function of normal human tissues and the influence of endogenous and exogenous factors on human tissues.
Department of Radiation Biology, Faculty of Medicine, Osaka University, Suita, Japan.
K
K
Fukuda
H
H
Nakajima
E
E
Taniguchi
K
K
Sutoh
H
H
Wang
P M
PM
Hande
L Y
LY
Li
M
M
Kurooka
K
K
Mori
T
T
Hongyo
T
T
Kubo
T
T
Nomura
D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000818:Animals; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008875:Middle Aged; D009368:Neoplasm Transplantation; D010281:Parathyroid Hormone / Q000378:metabolism; D010282:Parathyroid Neoplasms / Q000378:metabolism / Q000473:pathology; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism / Q000637:transplantation*; D013972:Thyrotropin / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014284:Triiodothyronine / Q000187:drug effects / Q000378:metabolism
D007457:Iodine Radioisotopes; D010281:Parathyroid Hormone; D014284:Triiodothyronine; D013972:Thyrotropin