Thoracic epidural anesthesia as an adjunct to general anesthesia for cardiac surgery: effects on ventilation-perfusion relationships.
OBJECTIVE
To determine the effects of thoracic epidural anesthesia (TEA) on ventilation-perfusion (VA/Q) relationships, atelectasis, and oxygenation before and after coronary artery bypass graft surgery (CABG).


METHODS
Prospective, controlled, unblinded, randomized trial.


METHODS
Cardiothoracic clinic at a major university referral center.


METHODS
Twenty-eight patients undergoing elective CABG.


METHODS
Perioperative and postoperative TEA was added to general anesthesia (GA) in 14 patients, and 14 patients receiving GA alone served as controls.


RESULTS
VA/Q relationships were measured by the multiple inert gas elimination technique, and, 20 hours postoperatively, atelectasis was assessed by computerized tomographic scans. Arterial and mixed venous blood gases and hemodynamic variables were measured by standard techniques. TEA per se caused no change in shunt, VA/Q matching, or oxygenation. Induction of GA in the control group and induction of TEA caused similar reductions in mean arterial pressure. The TEA patients needed less morphine analgesia postoperatively and were extubated earlier. Extubation caused significant improvement in VA/Q matching. On the first postoperative day, a slight reduction in PaCO2 was seen in the TEA group, but no differences in shunt, VA/Q matching, or oxygenation compared with the GA group. Both groups showed extensive bilateral atelectasis.


CONCLUSIONS
TEA can reduce respirator time and the need for morphine analgesics after CABG without negative effects on VA/Q matching, oxygenation, or atelectasis formation.
Department of Cardiothoracic Anesthesiology, University Hospital, Uppsala, Sweden.
A
A
Tenling
P O
PO
Joachimsson
H
H
Tydén
G
G
Wegenius
G
G
Hedenstierna
D000328:Adult; D000368:Aged; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001794:Blood Pressure; D001026:Coronary Artery Bypass; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D001261:Pulmonary Atelectasis / Q000209:etiology / Q000517:prevention & control; D014692:Ventilation-Perfusion Ratio