Micellar catalysis for oxidation of nitric oxide (NO) in the multi-phase systems in vivo.
The equation of the dependence of the third-order reaction acceleration due to concentrating the reagents in a small volume of the hydrophobic phase on the partition coefficients of reagents (Q) and on the lipophilic phase fraction (x), [k(app)/ k2 = H(Q(NO),Q(O2),x)] was analyzed. It was demonstrated that the numeric value of dH/dx at x-->0 could not be used in order to calculate the efficiency of catalysis from the experimental data. It was shown that, unlike in two-phase systems (with an aqueous and a hydrophobic phase), the dependence of H on Q in multi-phase systems, that include all in vivo systems, is different. The multiple phase state of the systems has a determining role for a regulation of NO-dependent processes and in the realization of conditions of 'NO catastrophes'.
Institute of Molecular Genetics, RAS, Moscow, Russia.
N V
NV
Beda
T P
TP
Suntsova
D002384:Catalysis; D008055:Lipids; D008823:Micelles; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry* / Q000378:metabolism*; D010084:Oxidation-Reduction; D012995:Solubility; D014867:Water
D008055:Lipids; D008823:Micelles; D014867:Water; D009569:Nitric Oxide