Lipase-catalysed acylation of prostanoids.
Natural prostaglandins (PG) F2alpha and E1 as well as (+)-cloprostenol were regioselectively 11-acylated using Novozym 435 as a catalyst and vinyl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE2 was also acylated with a significant velocity under the same conditions. The enantiospecificity of the lipase-catalysed 11-acetylation of cloprostenol was established by separate treatment of(+)- and (-)-cloprostenols.
Institute of Chemistry at Tallinn Technical University, Estonia. omar@boc.ic.ee
O
O
Parve
I
I
Järving
I
I
Martin
A
A
Metsala
I
I
Vallikivi
M
M
Aidnik
T
T
Pehk
N
N
Samel
D000215:Acylation; D008049:Lipase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D011453:Prostaglandins / Q000378:metabolism*
D011453:Prostaglandins; D008049:Lipase