Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children.
We report two cases of extrapyramidal reactions occurring in children following the use of droperidol in combination with morphine for patient-controlled analgesia (PCA). Symptoms appeared 38 and 27 h, respectively, after commencement and after a total dose of 0.14 mg.kg-1 and 0.17 mg.kg-1, respectively. Although effective and safe in adult patients, we recommend caution with the use of droperidol-morphine mixtures for PCA in paediatric patients.
Princess Margaret Hospital for Children, Perth, Western Australia.
W
W
Habre
D
D
Wilson
C M
CM
Johnson
D016058:Analgesia, Patient-Controlled / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D001062:Appendectomy; D001480:Basal Ganglia Diseases / Q000139:chemically induced* / Q000188:drug therapy; D001590:Benztropine / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D004329:Droperidol / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D010149:Postoperative Pain / Q000517:prevention & control; D010243:Paralysis / Q000139:chemically induced / Q000188:drug therapy; D013997:Time Factors; D014513:Ureter / Q000601:surgery
D000701:Analgesics, Opioid; D018492:Dopamine Antagonists; D018765:Dopamine Uptake Inhibitors; D004338:Drug Combinations; D001590:Benztropine; D009020:Morphine; D004329:Droperidol