Severe immune hemolytic anemia associated with prophylactic use of cefotetan in obstetric and gynecologic procedures.
Second- and third-generation cephalosporins, especially cefotetan, are increasingly associated with severe, sometimes fatal immune hemolytic anemia. We noticed that 10 of our 35 cases of cefotetan-induced hemolytic anemias were in patients who had received cefotetan prophylactically for obstetric and gynecologic procedures. Eight of these cases of severe immune hemolytic anemia are described.
Garratty
G
G
American Red Cross Blood Services, Southern California Region, Los Angeles, California, USA.
Leger
R M
RM
Arndt
P A
PA
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D019072:Antibiotic Prophylaxis / Q000009:adverse effects*; D015313:Cefotetan / Q000009:adverse effects*; D002513:Cephamycins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D013513:Obstetric Surgical Procedures; D011247:Pregnancy; D012720:Severity of Illness Index
D002513:Cephamycins; D015313:Cefotetan