Improvement of red pigment/citrinin production ratio as a function of environmental conditions by monascus ruber
The growth and metabolic behaviour of the filamentous fungus Monascus ruber were studied in submerged cultures under various aeration and agitation conditions. Improving the oxygen supply, by increasing either the air input or the agitation speed, resulted in modified metabolism: the biomass yield, the consumption of the nitrogen source (monosodium glutamate), and the production of secondary metabolites (red pigment and citrinin) all increased. However, the citrinin production increased more than that of the red pigment. In consequence, a low oxygen transfer coefficient was required to improve the red pigment/citrinin production ratio. Copyright 1999 John Wiley & Sons, Inc.
Hajjaj
H
Laboratoire Biotechnologie et Bioprocedes, UMR CNRS/INSA 5504, LA INRA, Centre de Bioingenierie Gilbert Durand, Institut National des Sciences Appliquees de Toulouse, Complexe Scientifique de Rangueil, F-31077 Toulouse Cedex 04, France.
Blanc
PJ
Groussac
E
Goma
G
Uribelarrea
JL
Loubiere
P