A null HLA-A*68 allele in a bone marrow donor.
The authors describe an A*68 allele present at the molecular level but not expressed at the cell surface. This non expression results from the deletion of one nucleotide in exon 1, which causes a shift of the reading frame leading to an early non-sense codon in the same exon.
Laforet
M
M
Laboratoire d'Histocompatibilité, Etablissement de Transfusion Sanguine, Strasbourg, France. hla@etss.u-strasbg.fr
Froelich
N
N
Parissiadis
A
A
Schell
A
A
Pfeiffer
B
B
Cazenave
J P
JP
Tongio
M M
MM
D000483:Alleles; D001854:Bone Marrow Cells / Q000737:chemistry* / Q000276:immunology*; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011544:Pseudogenes / Q000276:immunology
D015234:HLA-A Antigens; C053029:HLA-A*68 antigen