Favourable effect of K, Mg aspartate on serum proteins in aging rats.
The serum concentration of individual proteins in aging rats was studied. We have made an attempt to slow down the changes in concentration occurring in rats from 5 up to 17 months of age by application of aspartate given in drinking water containing 500 mg% of monopotassium DL asparagicum and 500 mg% of monomagnesium D,L asparagicum. The solution was administered continuously for 14 days a month for 1 year. In a part of animals, the aging process was accelerated by ionizing radiation with a single dose of 4.0 Gy. We found out that administration of aspartate caused slowing of changes in concentration of all proteins observed (prealbumin, albumin, A1-globulin, haptoglobin and hemopexin) in non-irradiated and prealbumin, albumin, A1-globulin in irradiated rats in comparison with the values of proteins in rats drinking water only. The preparation did not influence more significantly the changes in the serum concentration of haptoglobin and hemopexin in rats whose aging was accelerated by radiation. A favourable effect of the preparation used manifested also in the values of survival, because the animals protected with K, Mg aspartate survived by 25-30% longer.
Department of Anthropology and Zoology, Faculty of Science, Safárik University, Kosice, Slovak Republic. kaz@kosice.upjs.sk
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Chlebovská
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Chlebovský
D000375:Aging / Q000097:blood*; D000510:Alpha-Globulins / Q000032:analysis*; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000378:metabolism*; D001797:Blood Protein Electrophoresis / Q000379:methods; D006242:Haptoglobins / Q000032:analysis*; D007122:Immunoelectrophoresis / Q000379:methods; D008297:Male; D011228:Prealbumin / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000032:analysis*
D000510:Alpha-Globulins; D006242:Haptoglobins; D011228:Prealbumin; D012709:Serum Albumin; C028184:alpha-1 serum globulin; D001224:Aspartic Acid