Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus.
Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.
Istituto di Biologia Cellulare CNR, Istituto Superiore di Sanita', Rome, Italy.
B
B
Cardinali
L
L
Fiore
N
N
Campioni
A
A
De Dominicis
P
P
Pierandrei-Amaldi
D006801:Humans; D010766:Phosphorylation; D017955:Poliovirus / Q000502:physiology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D038601:Ribosomal Protein S6; D019893:Ribosomal Protein S6 Kinases / Q000378:metabolism; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D012333:RNA, Messenger; D038601:Ribosomal Protein S6; D012269:Ribosomal Proteins; C027624:ribosomal protein L11; C041806:ribosomal protein L32; C056368:ribosomal protein L4; D019893:Ribosomal Protein S6 Kinases