[Antiphospholipid syndrome].
Antiphospholipid syndrome is a well-defined clinical and serological entity characterized by arterial and/or venous thrombosis, recurrent abortion and thrombocytopenia. Anticardiolipin antibodies and lupus anticoagulant are autoantibodies directed against negatively charged phospholipids, which represent the serologic criteria for the diagnosis of the antiphospholipid syndrome. In this review the pathogenic mechanisms of anticardiolipin antibodies, their clinical findings and the current therapeutical strategies are discussed.
Yuste
J R
JR
Departamento de Medicina Interna, Facultad de Medicina, Universidad de Navarra.
Beloqui
O
O
De la Peña
A
A
Prieto
J
J
D000026:Abortion, Habitual / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy; D016913:Blood Component Transfusion; D003240:Connective Tissue Diseases / Q000150:complications; D005260:Female; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000276:immunology; D006681:HLA-D Antigens / Q000235:genetics / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007239:Infections / Q000150:complications; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019463:Mice, Inbred MRL lpr; D018716:Molecular Mimicry; D009369:Neoplasms / Q000150:complications; D011247:Pregnancy; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology; D015912:Thrombolytic Therapy; D019851:Thrombophilia / Q000188:drug therapy / Q000209:etiology; D053482:beta 2-Glycoprotein I
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants; D006023:Glycoproteins; D006681:HLA-D Antigens; D007166:Immunosuppressive Agents; D053482:beta 2-Glycoprotein I
Síndrome antifosfolípido.