Multiple-voxel double-quantum lactate-edited spectroscopy using two-dimensional longitudinal Hadamard encoding.
A conventional gradient-selected double-quantum lactate editing sequence was combined with fourth order two-dimensional longitudinal Hadamard encoding and slice-selective refocusing to acquire lactate-edited spectra in a 3 x 3 matrix of voxels. The performance of the sequence was verified in phantoms at 9.4 T and in focally ischemic rat brain at 7.0 T. Efficient suppression of water, lipid, and the singlet resonances of creatine, choline, and N-acetylaspartate was achieved, giving multi-voxel localized lactate-edited spectra with good signal-to-noise ratio.
Department of Chemistry, University of Manitoba, Winnipeg, Canada.
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D000818:Animals; D016477:Artifacts; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D007091:Image Processing, Computer-Assisted; D019344:Lactic Acid / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging; D051381:Rats
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline