Present status of hepatoprotectants.
Perpetual exposure of liver to xenobiotics and therapeutic agents leads to toxic manifestations of a complex and diverse nature. Not a single curative therapeutic agent has been found so far which could provide lasting remedy to patients suffering from hepatic disorders. In fact, the remedies available in the modern system of medicine provide only symptomatic relief without any significant changes on the disease process. Moreover, their use is associated with severe side effects and chances of relapses. Except some natural products claimed to be effective, no safe synthetic product is yet available for the management of hepatic disorders. Lack of effective, least toxic and curative hepatoprotectants made the task difficult to discover newer drugs. This review is an attempt to provide an overall view of the development of synthetic and natural products as hepatoprotective agents.
Ram
V J
VJ
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.
Goel
A
A
D000818:Animals; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000145:classification / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*