Early SjvO2 monitoring in patients with severe brain trauma.
OBJECTIVE
To investigate early cerebral variables after minimal resuscitation and to compare the adequacy of a cerebral perfusion pressure (CPP) guideline above 70 mmHg, with jugular bulb venous oxygen saturation (SjvO2) monitoring in a patient with traumatic brain injury (TBI).


METHODS
Prospective, observational study.


METHODS
Anesthesiological intensive care unit.


METHODS
27 TBI patients with a postresuscitation Glasgow Coma Scale score less than 8.


METHODS
After initial resuscitation, cerebral monitoring was performed and CPP increased to 70 mmHg by an increase in mean arterial pressure (MAP) with volume expansion and vasopressors as needed.


RESULTS
MAP, intracranial pressure (ICP), CPP, and simultaneous arterial and venous blood gases were measured at baseline and after treatment. Before treatment, 37% of patients had an SjvO2 below 55%, and SjvO2 was significantly correlated with CPP (r = 0.73, p < 0.0001). After treatment, we observed a significant increase (p < 0.0001) in CPP (78+/-10 vs 53+/-15 mmHg), MAP (103+/-10 vs 79+/-9 mmHg) and SvjO2 (72+/-7 vs 56+/-12), without a significant change in ICP (25+/-14 vs 25+/-11 mmHg).


CONCLUSIONS
The present study shows that early cerebral monitoring with SjvO2 is critical to assess cerebral ischemic risk and that MAP monitoring alone is not sensitive enough to determine the state of oxygenation of the brain. SjvO2 monitoring permits the early identification of patients with low CPP and high risk of cerebral ischemia. In emergency situations it can be used alone when ICP monitoring is contraindicated or not readily available. However, ICP monitoring gives complementary information necessary to adapt treatment.
Département d'Anesthésiologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France. darkb@.imaginet.fr
B
B
Vigué
C
C
Ract
M
M
Benayed
N
N
Zlotine
P E
PE
Leblanc
K
K
Samii
B
B
Bissonnette
D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis*; D002545:Brain Ischemia / Q000517:prevention & control; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D007601:Jugular Veins; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D010092:Oximetry; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric