[Secondary normal pressure hydrocephalus. A complication of chronic neuroborreliosis].
We report about a 57-year-old patient suffering from the typical symptoms of normal-pressure hydrocephalus (NPH) including gait disturbance, urinary incontinence, and mental deterioration. CSF analysis established the diagnosis of chronic active Lyme neuroborreliosis with lymphocytic pleocytosis and intrathecal Borrelia burgdorferi antibody production. After several weeks of i.v. antibiotic treatment we observed normalization of CSF parameters as well as a clear improvement of clinical symptoms so that surgical shunting was no longer indicated. Interference with subarachnoid CSF flow may be a possible cause of the observed symptomatic NPH in a patient with chronic Lyme neuroborreliosis.
Neurologische Klinik, Friedrich-Alexander-Universität Erlangen-Nürnberg.
K
K
Druschky
H
H
Stefan
H
H
Grehl
B
B
Neundörfer
D015748:Borrelia burgdorferi Group / Q000302:isolation & purification*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002443:Ceftriaxone / Q000627:therapeutic use; D002552:Cerebral Ventricles / Q000503:physiopathology; D002908:Chronic Disease; D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D005684:Gait; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D008193:Lyme Disease / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D014549:Urinary Incontinence / Q000209:etiology
D002443:Ceftriaxone
Sekundärer Normaldruckhydrozephalus. Komplikation der chronischen Neuroborreliose.