[Immobilized antigenic preparations with magnetic properties in the diagnosis and treatment of rheumatic diseases].
A procedure was first developed to prepare the immobilized granulated antigen agents (IGAA) based on collagens of types I, II, III, IgG, native DNA, RNA, cardiolipin, superoxide dismutase, and glutathione reductase. The agents were applied to both immunofluorescence and enzyme immunoassay to identify specific antibodies. IGAA were effective in early diagnosis, prognosis, and control of therapy for systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis due to their high capacity. These antigen agents were used in vitro and in vivo in hyperimmune laboratory animals as magnetic sorbents and exhibited high capacities and low traumatic properties for blood cells. IGAA may be regenerated, sterilized, and reused.
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Zborovskiĭ
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IP
Gontar'
D000918:Antibody Specificity; D000941:Antigens / Q000302:isolation & purification / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000097:blood; D007159:Immunologic Tests / Q000379:methods / Q000706:statistics & numerical data; D007163:Immunosorbent Techniques; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D008280:Magnetics / Q000627:therapeutic use*; D012044:Regression Analysis; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*
D000941:Antigens; D007132:Immunoglobulin Isotypes
Immobilizirovannye antigennye preparaty s magnitnymi svoĭstvami v diagnostike i lechenii revmaticheskikh zabolevaniĭ.