Positron emission tomography neuroreceptor imaging as a tool in drug discovery, research and development.
Improved communication and cooperation between research-driven drug companies and academic positron emission tomography (PET) centers, coupled with improvements in PET camera resolution, the availability of small animal PET cameras and a growing list of neuroreceptor-specific PET tracers, have all contributed to a substantial increase in the use and value of PET as a tool in central nervous system drug discovery and development.
Department of Pharmacology, Merck Research Laboratories, WP44C-2, Sumneytown Pike, West Point, PA 19438, USA. donald_burns@merck.com
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Burns
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Hamill
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Francis
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D000818:Animals; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D011984:Sensory Receptor Cells / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods*