The influence of developmental haemostasis on the laboratory diagnosis and management of haemostatic disorders during infancy and childhood.
The physiology of the hemostatic system in children is different from that in adults. Reference ranges for components of the hemostatic system are age dependent. During early childhood, physiologic values may overlap with values observed in congenital deficiencies of acquired pathological conditions. Physiologically decreased plasma concentrations of hemostatic components also influence the response to antithrombotic therapy. The relevance of developmental hemostasis for the laboratory diagnosis and management of hemorrhagic and thrombotic disorders during childhood is discussed.
Hospital for Sick Children, Toronto, Ontario, Canada.
C
C
Male
M
M
Johnston
C
C
Sparling
L
L
Brooker
M
M
Andrew
P
P
Massicotte
D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D019411:Clinical Laboratory Techniques; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006403:Hematologic Tests; D006487:Hemostasis / Q000502:physiology*; D020141:Hemostatic Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
D000925:Anticoagulants