Derivation of a possible transition-state for the reaction catalysed by the enzyme estrone Sulfatase (ES).
We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.
School of Applied Chemistry, Kingston University, Kingston upon Thames, Surrey, UK. S.AHMED@KINGSTON.AC.UK
S
S
Ahmed
K
K
James
D001665:Binding Sites; D002384:Catalysis; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013429:Sulfatases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
D004791:Enzyme Inhibitors; D013429:Sulfatases; C020121:estrone sulfatase