Molecular angiogenesis.
New insights into the mechanisms by which blood vessels develop (angiogenesis) have been gained recently, primarily by the identification of factors that inhibit and promote this process. Angiogenesis-stimulating factors are being used to promote growth of new blood vessels in ischemic disease. In contrast, anti-angiogenesis factors are being used as inhibitors of neovascularization to control tumor growth and metastasis.
Klagsbrun
M
M
Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. klagsbrun@a1.tch.harvard.edu.
Moses
M A
MA
D000818:Animals; D001808:Blood Vessels / Q000254:growth & development / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000502:physiology*; D004730:Endothelium, Vascular / Q000254:growth & development / Q000502:physiology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*
D016228:Endothelial Growth Factors