[The role of apoptosis in physiology and pathology of the retina].
Apoptosis is a genetically regulated form of cell death. Specific morphological and biochemical changes characterize apoptosis, including nuclear chromatin condensation, cytoplasmatic condensation, membrane blebbing and, on the molecular level, internucleosomal fragmentation of nuclear DNA. Cell death by apoptosis is essential for normal development and tissue homeostasis, and it is involved also in a variety of pathologic processes. Apoptosis is the final common pathway of photoreceptor cell death in retinal dystrophies and degeneration, retinal detachment, vitreoretinal proliferation, retinoblastoma and retinal injury. The authors present a brief literature review concerning studies on the role of apoptosis in pathogenesis on retinal diseases.
Obuchowska
I
I
Katedry i Kliniki Okulistyki AM w Białymstoku.
Stankiewicz
A
A
D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D006801:Humans; D012160:Retina / Q000502:physiology*; D012164:Retinal Diseases / Q000235:genetics / Q000473:pathology*; D019572:Retinal Neoplasms / Q000235:genetics / Q000473:pathology*; D012175:Retinoblastoma / Q000235:genetics / Q000473:pathology*; D018630:Vitreoretinopathy, Proliferative / Q000235:genetics / Q000473:pathology*
Znaczenie apoptozy w fizjologii i patologii siatkówki.