Three children with congenital toxoplasmosis: early report from a Swedish prospective screening study.
The aim of this prospective study was to define the incidence of congenital toxoplasmosis in Sweden. Blood eluates collected on filter papers, Guthrie cards, from 40978 newborn babies were analysed for specific immunoglobulin M (IgM) and IgG antitoxoplasma antibodies. This is a preliminary report of three children with congenital toxoplasmosis, defined by the occurrence of antitoxoplasma-specific IgM antibodies. Two children were asymptomatic at birth. They were both normally developed at the age of 12 and 15 months, respectively. The third child had unidentified but uncomplicated symptoms of infection in the neonatal period. As a result of the screening congenital toxoplasmosis was confirmed and treatment instituted. Microphthalmus and peripheral chorioretinitis were detected in one eye. In spite of the chemotherapeutic treatment he developed hydrocephalus needing neurosurgical intervention at the age of 3 months. His development at 14 months was normal. The incidence in Sweden of congenital toxoplasmosis detected by specific IgM antitoxoplasma antibodies in blood from filter papers is less than 1:10000.
Department of Paediatrics, Huddinge University Hospital, Sweden.
G
G
Malm
K
K
Teär Fahnehjelm
S
S
Wiklund
M L
ML
Engman
S A
SA
Ivarsson
K
K
Petersson
B
B
Evengård
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000276:immunology; D002557:Cerebrospinal Fluid Shunts; D002675:Child, Preschool; D005128:Eye Diseases / Q000175:diagnosis; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000601:surgery; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D015572:Spiramycin / Q000627:therapeutic use; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology
D000900:Anti-Bacterial Agents; D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015572:Spiramycin