alpha 2A-adrenoceptors, not I1-imidazoline receptors, mediate the hypotensive effects of rilmenidine and moxonidine in conscious mice. In vivo and in vitro studies.
Zhu
Q M
QM
Center for Biological Research, Roche Bioscience, Palo Alto, California 94304, USA. quan-ming.zhu@roche.com
Lesnick
J D
JD
Jasper
J R
JR
MacLennan
S J
SJ
Dillon
M P
MP
Eglen
R M
RM
Blue
D R
DR
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002460:Cell Line; D004285:Dogs; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007093:Imidazoles / Q000494:pharmacology*; D054755:Imidazoline Receptors; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology*; D011807:Quinolizines / Q000493:pharmacokinetics; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011955:Receptors, Drug / Q000502:physiology*; D000077769:Rilmenidine; D012501:Saphenous Vein / Q000187:drug effects / Q000502:physiology; D014162:Transfection
C547768:ADRA2A protein, human; C547769:Adra2a protein, mouse; D000959:Antihypertensive Agents; D007093:Imidazoles; D054755:Imidazoline Receptors; D010080:Oxazoles; D011807:Quinolizines; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; C054290:L 657743; D016244:Guanosine 5'-O-(3-Thiotriphosphate); C043482:moxonidine; D000077769:Rilmenidine; D009638:Norepinephrine