Pacinian collagenoma.
An unusual histological variant of collagenoma is described. A 36-year-old woman presented with a lump in the left hypothenar eminence. Histological examination revealed a well-delineated lesion composed of paucicellular collagen fibres arranged in concentric lamellations giving rise to an onion skin appearance. The overlying epidermis was thin and the lateral borders were demarcated by an epidermal collarette. Inflammation and xanthoma cells were absent and occasional capillaries were present. The lesion was positive for collagen stains, reticulin and CD34. This lesion represents an uncommon histological form of collagenoma or fibroma. It can be distinguished from histological look-alikes on the basis of the characteristic morphology and immunophenotype.
Department of Pathology, University of Natal School of Medicine, Private Bag 7, Congella 4013, Durban, South Africa. pillayp11@med.und.ac.za
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D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D003094:Collagen / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D010141:Pacinian Corpuscles; D012878:Skin Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D018952:Antigens, CD34; D003094:Collagen