Effects of Sho-seiryu-to on experimental allergic rhinitis in guinea pigs.
The effects of Sho-seiryu-to, an antiallergic Kampo medicine, on experimental allergic rhinitis were investigated in actively sensitized guinea pigs. The number of sneezes and scratches by the animals after a topical antigen challenge was significantly inhibited by pretreatment with Sho-seiryu-to (1000 mg/kg per os p.o.). The antigen-induced eosinophil infiltration in the nasal mucosa was significantly inhibited by Sho-seiryu-to (1000 mg/kg p.o.). Sho-seiryu-to (100 mg/kg p.o.) also reduced the increase in dye leakage to the nasal cavity induced by the antigen challenge and the antigen-induced decrease in volume of the nasal cavity was inhibited. Moreover, Sho-seiryu-to (1000 mg/kg p.o.) suppressed the volume change in the nasal cavity induced by leukotriene D4. These results demonstrate that Sho-seiryu-to inhibits experimental allergic rhinitis in guinea pigs, confirming that the agent may be beneficial for the treatment of allergic rhinitis.
Central Research Laboratories, Tsumura & Co., Ibaraki, Japan. hirokoma@po.iijnet.or.jp
M
M
Sakaguchi
A
A
Mase
Y
Y
Ikeda
A
A
Iizuka
S
S
Imamura
Y
Y
Komatsu
K
K
Ukai
Y
Y
Sakakura
D000818:Animals; D000941:Antigens / Q000009:adverse effects / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects; D002464:Cell Migration Inhibition; D004396:Coloring Agents / Q000493:pharmacokinetics; D004804:Eosinophils / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000276:immunology / Q000627:therapeutic use*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D000941:Antigens; D004396:Coloring Agents