Protein kinase C--a potential modifier of carotid body function.
This article deals with the potential role of protein kinase C (PKC) in signal transduction in the carotid body. The carotid body is a chemosensory organ which, by sensing reductions in arterial blood oxygen tension, is primarily responsible for the hyperventilation of hypoxia. The mechanisms of transduction of the hypoxic stimulus into a neural signal regulating respiration are not clear. Hypoxia increases the phosphoinositide-specific phospholipase C (PLC) activity in the carotid body. The PLC-derived signalling molecules are known to activate PKC. The enzyme might, thus, have the potential to interact with the process of chemoreception. This article demonstrates that PKC is present in the chemoreceptor cells of the cat carotid body and discusses the biology of the enzyme relevant to chemosensory function. This gives rise to the hypothesis that PKC-mediated mechanisms alter chemoreceptor cell function to a sufficient extent to metamorphose the hypoxic signal into an increased discharge frequency in the apposed sinus nerve endings.
Dept of Neurophysiology, Medical Research Centre, Warsaw, Poland.
L
L
Faff
C
C
Kowalewski
M
M
Pokorski
D000818:Animals; D002344:Carotid Body / Q000201:enzymology* / Q000502:physiology; D002415:Cats; D002628:Chemoreceptor Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011493:Protein Kinase C / Q000032:analysis / Q000378:metabolism*; D011956:Receptors, Cell Surface; D015656:Respiratory Mechanics / Q000502:physiology*; D012680:Sensitivity and Specificity
D011956:Receptors, Cell Surface; D011493:Protein Kinase C