The effect of propofol and thiamylal on hypertensive responses to a rapid increase in isoflurane concentration.
OBJECTIVE
To compare the effects of propofol and thiamylal on the hyperdynamic circulatory response caused by a rapid increase in isoflurane concentration.


METHODS
Prospective, randomized, double-blind study.


METHODS
Operating rooms of a university hospital.


METHODS
30 ASA physical status I adult patients scheduled for elective surgery with general anesthesia.


METHODS
Patients were anesthetized with either propofol 2 mg/kg (propofol group, n = 15) or thiamylal 4 mg/kg (thiamylal group, n = 15). Two minutes after anesthesia induction, the inspired isoflurane concentration was rapidly increased from 0.5% to 5% and maintained for 5 minutes.


RESULTS
Mean arterial pressure significantly increased after the increase in isoflurane concentration in the thiamylal group, but it did not change in the propofol group. The isoflurane-induced increase in rate-pressure product was significantly greater in the thiamylal group than in the propofol group.


CONCLUSIONS
Propofol induction of anesthesia more effectively attenuates the circulatory responses to a sudden increase in isoflurane concentration than does thiamylal.
Department of Anesthesiology, Sapporo Medical University School of Medicine, Japan.
M
M
Nakayama
N
N
Kanaya
H
H
Tsuchida
A
A
Namiki
D000328:Adult; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D015742:Propofol; D013840:Thiamylal; D013997:Time Factors; D016896:Treatment Outcome
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D013840:Thiamylal; D007530:Isoflurane; D015742:Propofol