Arterial structural changes with verapamil in spontaneously hypertensive rats.
Reducing pulse pressure might be more powerful than reducing mean arterial pressure to obtain regression of vascular hypertrophy. However, this hypothesis has never been investigated in the conduit arteries of intact hypertensive animals. A group of 4-week-old spontaneously hypertensive rats (SHR) was treated with the calcium-entry blocker verapamil (50 mg/kg) for 16 weeks and compared with untreated SHR and control Wistar Kyoto (WKY) normotensive rats of the same age. At the end of the experiment, intraarterial thoracic aorta blood pressure was measured both in the conscious and anesthetized animals. Carotid artery diameter and stiffness (echo-tracking techniques) and aortic histomorphometry were determined in parallel. With verapamil, pulse pressure, but not mean arterial pressure, was significantly decreased but did not reach the normotensive values. Carotid internal diameter, medial thickness, and collagen content were significantly reduced by comparison with SHR and did not differ from the values of the WKY group. A significant positive and independent correlation was observed between pulse pressure and medial thickness in the overall population. The study shows that, in SHR chronically treated with verapamil, structural changes may be completely prevented without any change in mean arterial pressure. The parallel change in pulse pressure might suggest that mechanosensitive elements within the vascular wall may be selectively sensitive to the dynamic aspects of physical forces and are able to convert frequency and amplitude information into cellular responses that lead to vascular remodeling.
Department of Internal Medicine and INSERM U337, Broussais Hospital, Paris, France.
I
I
Koffi
M E
ME
Safar
C
C
Labat
P
P
Lacolley
A
A
Benetos
J J
JJ
Mourad
D000818:Animals; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005500:Follow-Up Studies; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D018084:Ultrasonography, Interventional; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D003094:Collagen; D004549:Elastin; D014700:Verapamil