The structural era of endocytosis.
Endocytosis is crucial for an array of cellular functions and can occur through several distinct mechanisms with the capacity to internalize anything from small molecules to entire cells. The clathrin-mediated endocytic pathway has recently received considerable attention because of (i) the identification of an array of molecules that orchestrate the assembly of clathrin-coated vesicles and the selection of the vesicle cargo and (ii) the resolution of structures for a number of these proteins. Together, these data provide an initial three-dimensional framework for understanding the clathrin endocytic machinery.
Marsh
M
M
Medical Research Council Laboratory for Molecular Cell Biology and Department of Biochemistry, University College London, Gower Street, London WC1E 6BT, UK. m.marsh@ucl.ac.uk
McMahon
H T
HT
D000818:Animals; D001665:Binding Sites; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000502:physiology; D002462:Cell Membrane / Q000648:ultrastructure; D002966:Clathrin / Q000737:chemistry / Q000502:physiology*; D003034:Coated Pits, Cell-Membrane / Q000502:physiology / Q000648:ultrastructure; D018699:Coated Vesicles / Q000502:physiology / Q000648:ultrastructure; D034281:Dynamins; D004705:Endocytosis; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction
D002135:Calcium-Binding Proteins; D002966:Clathrin; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; C075637:amphiphysin; D020558:GTP Phosphohydrolases; D034281:Dynamins