Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?
Painful peripheral neuropathies are precipitated by nerve injury from disease or trauma. All such injuries will be accompanied by an inflammatory reaction, a neuritis, that will mobilize the immune system. The role of the inflammation itself is difficult to determine in the presence of structural damage to the nerve. A method has been devised to produce a focal neuritis in the rat sciatic nerve that involves no more than trivial structural damage to the nerve. This experimental focal neuritis produces neuropathic pain sensations (heat- and mechano-hyperalgesia, and cold- and mechano-allodynia) in the ipsilateral hind paw. The abnormal pain sensations begin in 1-2 days and last for 4-6 days, with a subsequent return to normal. These results suggest that there is a neuroimmune interaction that occurs at the outset of nerve injury (and perhaps episodically over time in slow developing conditions like diabetic neuropathy) that produces neuropathic pain. The short duration of the phenomena suggest that they may prime the system for more slowly developing mechanisms of abnormal pain (e.g., ectopic discharge in axotomized primary afferent neurons) that underlie the chronic phase of painful neuropathy.
Bennett
G J
GJ
Department of Neurology, MCP Hahnemann University, Philadelphia, PA 19102, USA. bennettg@auhs.edu
D000818:Animals; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology; D007107:Immune System / Q000503:physiopathology; D009437:Neuralgia / Q000276:immunology / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000503:physiopathology*; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology / Q000503:physiopathology*