Biomimicry 1: PC.
The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.
Cardiovascular Group, Clinical Sciences Centre, Northern General Hospital, Sheffield, UK. d.c.cumberland@sheffield.ac.uk
D C
DC
Cumberland
J
J
Gunn
N
N
Malik
C M
CM
Holt
D000818:Animals; D020099:Coated Materials, Biocompatible; D003331:Coronary Vessels; D006801:Humans; D010767:Phosphorylcholine; D011108:Polymers; D011474:Prosthesis Design; D015607:Stents
D020099:Coated Materials, Biocompatible; D011108:Polymers; D010767:Phosphorylcholine