[Cytogenetic aspects of malignant melanoma].
In analogy to colon carcinoma, where a stepwise accumulation of genetic changes have been described during tumor progression, a sequence of genetic events may be responsible for the transformation of melanocytes to dysplastic nevi and melanoma with horizontal and vertical growth phases and finally the formation of distant metastases. The current literature supporting this concept as well as own contributions are presented.
Dermatologische Klinik, Universitätsspital Zürich.
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D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
Zytogenetische Aspekte des malignen Melanoms.