Gene related to stroke in stroke-prone spontaneously hypertensive rats.
1. In order to study genes related to stroke in stroke-prone spontaneously hypertensive rats (SHRSP), linkage analysis was performed using F2 rats (SHRSP/Izm x WKY/Izm). The brainweight that reflected cerebral stroke in F2 rats showed cosegregation with three genetic markers, D4Mit19 (P < 0.0015), D4Mgh7 (P < 0.0014) and D4Mgh8 (P < 0.004) on chromosome 4, but not blood pressure. 2. These results suggest that a chromosomal region other than the region responsible for hypertension contributes to the development of stroke in SHRSP.
Otsuka Department of International Preventive Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
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Ikeda
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Yamori
D000818:Animals; D001921:Brain / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000235:genetics*; D002874:Chromosome Mapping; D006973:Hypertension / Q000235:genetics*; D009929:Organ Size; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY