Filtration procedures supplemented with mitomycin C in the management of childhood glaucoma.
OBJECTIVE
To evaluate the outcome of filtering procedures supplemented with mitomycin C in children with glaucoma.


METHODS
All patients aged 17 or younger with glaucoma who underwent filtering surgery supplemented with mitomycin C at a tertiary care centre (n = 21) during a 5 year interval (1992 and 1996) were included. One eye for each patient was entered into the analysis. The postoperative intraocular pressure (IOP), use of antiglaucoma medications, clinical stability of glaucoma, complications, and visual acuity were retrospectively evaluated. Kaplan-Meier survival curves were used to estimate the probability of success.


RESULTS
At the time of surgery mean age was 5.7 (SD 5.0) years. The most common diagnoses were trabeculodysgenesis (n = 6) and aphakic glaucoma (n = 8). Mean IOP before surgery was 35.7 (10.5) mm Hg. Average length of follow up was 18.6 (14.7) months. The probability of having IOP less than 21 mm Hg with no antiglaucoma medications and with clinically stable glaucoma 1 year after surgery was 76.9% in phakic eyes (n = 13) and 0% in aphakic eyes (n = 8). A phakic patient with Sturge-Weber's syndrome had choroidal effusion after surgery that resolved spontaneously. In the aphakic group one patient had retinal detachment and another developed an encapsulated bleb. Visual acuity deteriorated in one patient.


CONCLUSIONS
A guarded filtration procedure with mitomycin C is relatively successful in phakic children with glaucoma, but unsuccessful in aphakic ones.
Glaucoma Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, USA.
A
A
Azuara-Blanco
R P
RP
Wilson
G L
GL
Spaeth
C M
CM
Schmidt
J J
JJ
Augsburger
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D018463:Filtering Surgery / Q000379:methods; D005500:Follow-Up Studies; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011182:Postoperative Care; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology
D016685:Mitomycin