Axon guidance: A balance of signals sets axons on the right track.
Axon guidance depends on the transduction of extracellular guidance cues into motile responses by the axonal growth cone. Recent studies in vivo have elucidated mechanisms required for this process that involve kinases and phosphatases, calcium dynamics and remodeling of the actin cytoskeleton.
Gallo
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University of Minnesota, Department of Cell Biology and Neuroanatomy, 4-102 Owre Hall, 435 Delaware Street SE, Minneapolis, Minnesota 55455, USA.
Letourneau
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PC
D000818:Animals; D001369:Axons / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004330:Drosophila; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D010770:Phosphotransferases / Q000502:physiology; D015398:Signal Transduction; D014981:Xenopus
D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases; D002118:Calcium