N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage.
Bone morphogenetic protein (BMP), associated with N,N-dicarboxymethyl chitosan, is used to induce or facilitate the repair of articular cartilage lesions. This association is intended for the synergistic potentiation of the respective biological effects. Data show that BMP-7 enhances the in vivo proliferation of cells with chondrocytes phenotype in the articular environment, leading to partial healing of the articular surface of the lesions. N,N-dicarboxymethyl chitosan is found to be useful as a molecular carrier or drug delivery agent.
Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Italy. belmonte@popsci.unian.it
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M
Mattioli-Belmonte
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Gigante
R A
RA
Muzzarelli
R
R
Politano
A
A
De Benedittis
N
N
Specchia
A
A
Buffa
G
G
Biagini
F
F
Greco
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000187:drug effects / Q000293:injuries* / Q000473:pathology; D002686:Chitin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D004337:Drug Carriers; D008297:Male; D011817:Rabbits; D012038:Regeneration; D016212:Transforming Growth Factor beta
D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D016212:Transforming Growth Factor beta; D002686:Chitin