HLA-B*4703: sequence confirmation, serology and distribution.
This study has confirmed the nucleotide sequence of exons 2 and 3 of the B*4703 allele, discovered by an unusual HLA-B47 and Bw6 serological pattern, in two subjects of Black/Japanese and Caribbean Black descent. Titration studies on 25 HLA-B47 cross-reactive sera, stimulated by B13, B27, B44 and B60, and nine Bw6 antisera/monoclonal antibodies, showed that the B*4703 product can be distinguished from the established HLA-B47 specificity. The phenotypes of these donors and an International Cell Exchange donor suggests an association between B*4703 and Cw*0701/ 06 in Black subjects. No examples of B*4703 (or B*4702) were found in 10,194 PCR-SSP HLA-A,B typed Welsh Bone Marrow Donor Registry panel members indicating a phenotype frequency of <0.0098% in this primarily Northern European Caucasoid population.
Regional Tissue Typing Laboratory, Welsh Blood Service, Cardiff, United Kingdom. cdarke@wbmdr.demon.co.uk
C
C
Darke
M G
MG
Guttridge
J
J
Street
J
J
Thompson
M
M
Thomas
D000483:Alleles; D044466:Asian People; D044383:Black People; D005060:Europe; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D044465:White People
D015235:HLA-B Antigens; C106993:HLA-B47 antigen; C038652:HLA-Bw6 antigen