Analysis in spontaneously hypertensive rats.
1. Linkage analysis is performed between basal or salt-sensitive high blood pressure and several loci on chromosomes in F2 progenies obtained from crossing stroke-prone spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats. 2. Basal hypertensive genes are mapped to a region near the D1Mit2 locus on chromosome 1 and near the D3Mgh8 locus on chromosome 3 in the male and female F2 progenies. 3. Salt-sensitive hypertensive gene is mapped to a region near RR1023 locus on chromosome 10 in the male F2 progenies. 4. Salt-sensitive hypertensive gene is mapped to a region near D3Mgh12 locus on chromosome 3 in the female F2 progenies.
Graduate School of Integrated Science and Art, University of East Asia Shimonoseki, Japan.
Y
Y
Nara
T
T
Mashimo
T
T
Tamada
C
C
Matsumoto
Y
Y
Ishinaga
T
T
Nabika
K
K
Ikeda
M
M
Sawamura
Y
Y
Yamori
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017673:Sodium Chloride, Dietary
D017673:Sodium Chloride, Dietary