[Persistent arthralgias in Ross-River-Virus disease after travel to the South Pacific].
METHODS
A 57-year-old patient presented with malaise and severe persistent arthralgia of the left shoulder. He reported an acute illness with fever, generalized myalgia and arthralgias of the large joints which had started one month earlier during his flight back to Germany after a two weeks trip to the South Pacific. Physical examination showed extensive pain on palpation of the glenohumeral and acromioclavicular joints with impairment of active and passive mobility. Investigation of the cervical spine was normal.


METHODS
Apart from elevated C-reactive protein and erythrocyte sedimentation rate levels, routine laboratory investigations were normal including negative immunodiagnostic tests for autoantibodies and various global infections that may be associated with arthritis. Immunofluorescence tests showed significant levels of specific IgM- and IgG-antibodies against Ross River virus (RRV) but not against other arboviruses endemic in the South Pacific and Australia (Dengue, West Nile, Chikungunya, Sindbis, Barmah Forest). This was confirmed by a positive RRV neutralisation test. Attempts at virus isolation and detection of viral RNA by PCR were not successful.


METHODS
Symptomatic treatment with high doses of diclofenac quickly led to pain relief, and arthralgias receded within 10 days after begin of treatment. However, several bouts of arthralgia of the left shoulder and left knee occurred during a period of 4 months.


CONCLUSIONS
Because of the current epidemiological situation in the South Pacific and Australia, infections by arboviruses like RRV should be considered in travellers returning from these areas with severe and persistent arthralgia of unknown origin, even in the absence of fever and other symptoms of acute infection.
Abteilung für Infektions- und Tropenmedizin, Klinikum Innenstadt. proell@lrz.uni-muenchen.de
S
S
Pröll
G
G
Dobler
M
M
Pfeffer
T
T
Jelinek
H D
HD
Nothdurft
T
T
Löscher
D018354:Alphavirus Infections / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D000914:Antibodies, Viral / Q000097:blood; D018771:Arthralgia / Q000821:virology*; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007719:Knee Joint / Q000821:virology; D008297:Male; D008875:Middle Aged; D010139:Pacific Islands; D016059:Range of Motion, Articular; D012398:Ross River virus / Q000276:immunology; D012785:Shoulder Joint / Q000821:virology; D014195:Travel
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Persistierende Arthralgien bei Ross-River-Virus-Erkrankung nach Ozeanien-Reise.