Synaptic mechanisms of bipolar cell terminals.
Giant synaptic terminals of goldfish bipolar neurons allow direct studies of presynaptic mechanisms underlying neurotransmitter release and its modulation. Calcium influx via L-type calcium channels of the terminal triggers synaptic vesicle exocytosis, which can be monitored in isolated terminals by means of the associated changes in membrane capacitance. Information about the kinetics and calcium dependence of synaptic exocytosis has been obtained from capacitance measurements in these ribbon-type synaptic terminals.
Matthews
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Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230, USA. gary.g.matthews@sunysb.edu
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology; D004553:Electric Conductivity; D005089:Exocytosis; D006054:Goldfish; D009411:Nerve Endings; D018377:Neurotransmitter Agents / Q000378:metabolism; D012160:Retina / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D013572:Synaptic Vesicles / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D002118:Calcium