Biclonal lymphoplasmacytic immunocytoma associated with Crohn's disease.
A 33-year-old man with a 4-year history of Crohn's disease presented with marked ascites and an abdominal tumor. Two M-protein peaks, immunoglobulin (Ig) G-kappa and IgA-kappa, were detected in the serum. Neoplastic lymphoplasmacytic cells were infiltrated in the bone marrow and ascites. Histological examination of the abdominal tumor showed marked proliferation of lymphoplasmacytic cells that were positive for either IgG or IgA. Moreover, DNA sequences of the expressed IgG and IgA genes were different in the complementarity-determining region 3. These results suggest that chronic inflammation in Crohn's disease contributes to the simultaneous development of biclonal lymphoplasmacytic immunocytoma of the small intestine.
First Department of Internal Medicine, School of Medicine, University of Tokushima.
T
T
Hara
S
S
Ozaki
M
M
Kosaka
S
S
Fujiwara
Y
Y
Wakahara
H
H
Endo
S
S
Wakatsuki
T
T
Matsumoto
D000008:Abdominal Neoplasms / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D001201:Ascites / Q000209:etiology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D003092:Colitis / Q000150:complications / Q000175:diagnosis; D003113:Colonoscopy; D003424:Crohn Disease / Q000150:complications* / Q000175:diagnosis; D017931:DNA Primers / Q000737:chemistry; D017809:Fatal Outcome; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications* / Q000175:diagnosis; D007070:Immunoglobulin A / Q000235:genetics; D007074:Immunoglobulin G / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D016133:Polymerase Chain Reaction; D012334:RNA, Neoplasm / Q000032:analysis; D014057:Tomography, X-Ray Computed
D017931:DNA Primers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012334:RNA, Neoplasm