title: Improving high-resolution MR bold venographic imaging using a T1 reducing contrast agent.
abstract: Recently, a new imaging method was proposed by Reichenbach et al (Radiology 1997;204:272-277) to image small cerebral venous vessels specifically. This method, referred to as high-resolution blood oxygen level-dependent venography (HRBV), relies on the susceptibility difference between the veins and the brain parenchyma. The resulting phase difference between the vessels and the brain parenchyma leads to signal losses over and above the usual T2* effect. At 1.5 T, a rather long TE (roughly 40 msec) is required for this cancellation to become significant, leading to enhanced susceptibility artifacts and a long data acquisition time. In this study, we examine the utility of incorporating a clinically available T1 reducing contrast agent, Omniscan (Sanofi Winthrop Pharmaceuticals, NY, NY), with the HRBV imaging approach to reduce susceptibility artifacts and imaging time while maintaining the visibility of cerebral veins. Using a double-dose injection of Omniscan, we were able to reduce TE from 40 to 25 msec. This led to a decrease in TR from 57 to 42 msec, allowing a 26% reduction in data acquisition time while maintaining the visibility of cerebral venous vessels and reducing susceptibility artifacts. J. Magn. Reson. Imaging 1999;10:118-123, 1999.
authors.affiliation: Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, USA. wili@mirlink.wustl.edu
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.forename: P
authors.initials: P
authors.lastname: Mukherjee
authors.forename: H
authors.initials: H
authors.lastname: An
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Vo
authors.forename: B
authors.initials: B
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Kido
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
mesh_terms: D016477:Artifacts; D002550:Cerebral Veins / Q000033:anatomy & histology*; D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods* / Q000706:statistics & numerical data; D012016:Reference Values; D013997:Time Factors
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA