[Brain monoaminoxidase during late ontogenesis in rats genetically predisposed to pendulum-like movements].
Rats genetically predisposed (PM+) and non-predisposed (PM-) to pendulum movement (spontaneous nystagm) were studied at different age. In old PM+ and PM- rats the brain MAO-A activity did not differ, unlike between young PM+ and PM- rats. In old PM+ and PM- rats, brain stem MAO-A activity was higher than in young ones. Actinomycin D lowered brain stem MAO-A activity in PM+ and PM- rats. In the absence of actinomycin D, stress elevated MAO-B activity in the brain stem of PM- rats, and a preliminary actinomycin D administration prevent the MAO-B activating effect of stress. Possible differences in MAO-A and MAO-B regulation at transcription level in PM+ and PM- are discussed.
Voĭtenko
N N
NN
Institute of Cytology and Genetics, Siberian Branch of the Russian Acad.Sci., Novosibirsk, Russia.
Barykina
N N
NN
Kolpakov
V G
VG
D000375:Aging; D000818:Animals; D001921:Brain / Q000201:enzymology*; D020022:Genetic Predisposition to Disease; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019956:Stereotypic Movement Disorder / Q000201:enzymology* / Q000235:genetics; D013315:Stress, Psychological / Q000201:enzymology / Q000235:genetics
D008995:Monoamine Oxidase
Monoaminoksidaza mozga u geneticheski predraspolozhennykh k maiatnikoobraznym dvizheniiam krys v pozdnem ontogeneze.