title: Continuous desferrioxamine infusion by an infusor in thalassaemia major.
abstract: Chelation therapy with desferrioxamine (DFO) can be an important problem for patients with thalassaemia major (TM). In an effort to find a solution to this problem, a new delivery system based on a disposable and lightweight device was developed by Baxter. The aim of study was to investigate the compliance of patients and the effects and side effects of two different infusors. The 26 patients using infusors were divided into 2 groups, who were infused with DFO for 48 h (group A) and for 120 h (group B). The 24-h mean urinary iron and zinc excretion in groups A and B were statistically significant at the beginning and end of therapy (p < 0.001). Serum ferritin levels decreased in both groups compared with control (p < 0.001). No systemic reactions were observed either during or at the end of treatment. The compliance and use of infusors were 97% in group A and 72% in group B. In conclusion, better compliance was achieved and there were fewer local complications in group A than in group B. Subcutaneous infusion of DFO with both devices may be ideal for patients who have compliance problems and cannot be treated using portable pumps. The device is new and expensive, but excellent and effective for long-term DFO infusion.
authors.affiliation: Thalassemia Center, State Hospital of Antalya and Research Center, Ankara, Turkey. akhav@aidata.com.tr
authors.forename: D
authors.initials: D
authors.lastname: Canatan
authors.forename: N
authors.initials: N
authors.lastname: Temimhan
authors.forename: N
authors.initials: N
authors.lastname: Dinçer
authors.forename: A
authors.initials: A
authors.lastname: Ozsancak
authors.forename: N
authors.initials: N
authors.lastname: Oğuz
authors.forename: M
authors.initials: M
authors.lastname: Temimhan
mesh_terms: D000293:Adolescent; D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use*; D002648:Child; D003676:Deferoxamine / Q000627:therapeutic use*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007260:Infusion Pumps; D007501:Iron / Q000652:urine; D008111:Liver Function Tests; D008134:Long-Term Care; D008297:Male; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D015032:Zinc / Q000652:urine; D017086:beta-Thalassemia / Q000188:drug therapy*
chemical_list: D002614:Chelating Agents; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine; D015032:Zinc