Stem cell escalation enables HLA-disparate haematopoietic transplants in leukaemia patients.
Resistance to engraftment of bone marrow transplants appears to be mediated by host-derived cytotoxic T-cell precursors that survive supralethal conditioning. Here, Yair Reisner and Massimo Martelli review engraftment studies showing that escalation of haematopoietic progenitor cell dose induces transplantation tolerance, thereby overcoming major genetic histocompatibility barriers.
Reisner
Y
Y
Dept of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. bfrisner@weizmann.weizmann.ac.il
Martelli
M F
MF
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D006680:HLA Antigens; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D051379:Mice; D011828:Radiation Chimera / Q000276:immunology
D006680:HLA Antigens