title: A prospective placebo controlled double blind randomised study to investigate the use of indoramin to prevent post-operative voiding disorders after surgical treatment for genuine stress incontinence.
abstract: A prospective placebo controlled double blind randomised study was undertaken to investigate the use of indoramin an alpha blocker to prevent post-operative voiding disorders after surgical treatment for genuine stress incontinence. Fifty-six patients were randomised to receive indoramin 20 mg orally twice a day or identical placebo from the first post-operative day until discharge from hospital. After seven exclusions, 49 patients were included in the study. There was no significant difference between the treatment (indoramin) group and placebo group for any of the outcomes measured. The routine use of indoramin to prevent post-operative voiding problems cannot be justified on the basis of these data.
authors.affiliation: Department of Obstetrics and Gynaecology, St. James's University Hospital, Leeds, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Watson
authors.forename: I
authors.initials: I
authors.lastname: Currie
authors.forename: G J
authors.initials: GJ
authors.lastname: Jarvis
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007217:Indoramin / Q000627:therapeutic use*; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D014550:Urinary Incontinence, Stress / Q000601:surgery*; D016055:Urinary Retention / Q000517:prevention & control*
chemical_list: D000317:Adrenergic alpha-Antagonists; D007217:Indoramin