title: Exclusion of linkage to the HLA region in ninety multiplex sibships with autism.
abstract: Several studies have suggested a role for the histocompatibility complex of loci (HLA) in the genetic susceptibility to autism. We have tested this hypothesis by linkage analysis using genetic marker loci in the HLA region on chromosome 6p in multiplex families with autism. We have examined sharing of alleles identical by descent in 97 affected sib pairs from 90 families. Results demonstrate no deviation from the null expectation of 50% sharing of alleles in this region; in fact, for most marker loci, the observed sharing was less than 50%. Thus, it is unlikely that loci in this region contribute to the genetic etiology of autism to any significant extent in our families.
authors.affiliation: Centre for Human Genetics, Edith Cowan University, Perth, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Rogers
authors.forename: L
authors.initials: L
authors.lastname: Kalaydjieva
authors.forename: J
authors.initials: J
authors.lastname: Hallmayer
authors.forename: P B
authors.initials: PB
authors.lastname: Petersen
authors.forename: P
authors.initials: P
authors.lastname: Nicholas
authors.forename: C
authors.initials: C
authors.lastname: Pingree
authors.forename: W M
authors.initials: WM
authors.lastname: McMahon
authors.forename: D
authors.initials: D
authors.lastname: Spiker
authors.forename: L
authors.initials: L
authors.lastname: Lotspeich
authors.forename: H
authors.initials: H
authors.lastname: Kraemer
authors.forename: P
authors.initials: P
authors.lastname: McCague
authors.forename: S
authors.initials: S
authors.lastname: Dimiceli
authors.forename: N
authors.initials: N
authors.lastname: Nouri
authors.forename: T
authors.initials: T
authors.lastname: Peachy
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Hinds
authors.forename: N
authors.initials: N
authors.lastname: Risch
authors.forename: R M
authors.initials: RM
authors.lastname: Myers
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D016133:Polymerase Chain Reaction
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens