title: Phytotoxic and photosynthetic activities of maduramicin and maduramicin methyl ester.
abstract: The polyether antibiotic maduramicin and its methyl ester derivative inhibited photophosphorylation and proton uptake in isolated spinach chloroplasts. Both compounds also enhanced basal and phosphorylating electron transport and stimulated Mg(2+)-dependent ATPase activity, therefore, they behave as uncouplers of photophosphorylation being the methyl ester derivative more potent than the parent compound. On the other hand, maduramicin inhibited germination and radicle elongation of several crop and weed species. In addition, the antibiotic caused phytotoxic injury and fresh weight reduction to 4-to-6 week old seedlings of two weed and two crop species when applied at 10(-4) M by foliar application in the greenhouse.
authors.affiliation: Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, D. F., México.
authors.forename: M T
authors.initials: MT
authors.lastname: Gutiérrez-Lugo
authors.forename: B
authors.initials: B
authors.lastname: Lotina-Hennsen
authors.forename: A
authors.initials: A
authors.lastname: Farrés
authors.forename: S
authors.initials: S
authors.lastname: Sánchez
authors.forename: R
authors.initials: R
authors.lastname: Mata
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002736:Chloroplasts / Q000187:drug effects / Q000378:metabolism*; D004579:Electron Transport / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010785:Photophosphorylation / Q000187:drug effects*; D010788:Photosynthesis / Q000187:drug effects*; D063245:Plant Development; D010944:Plants / Q000187:drug effects; D018724:Spinacia oleracea / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007783:Lactones; C018091:maduramicin