[An analysis of bacterial resistance to antimicrobial agents in a burn centre].
OBJECTIVE
To investigate bacterial resistance to antimicrobial agents in the background of extensive employment of third-generation cephalosporins in the treatment of burn infection.


METHODS
Bacterial susceptibility testing was carried out using Kirby-Bauer method.


RESULTS
Out of 259 Gram negative bacilli isolates, 31% of these strains were all resistant to cefotaxime, ceftriaxone, cefoperazone and ceftazidime. In vitro test, susceptibility of 52% third-generation cephlosporins resistant strains were restored by cefoperazone/sulbactum. 23.8% of P. aeruginosa were resistant to imipenem, 51.2% to ciprofloxacin. 28.6% of A. anitratum were resistant to imipenem, 21.4% to ciprofloxacin. 9.9% of enterobacteriaceae were resistant to imipenem, 20.4% to ciprofloxacin. 26.9% of MRSA were resistant to imipenem, 73% to ciprofloxacin. No norvancomycin resistance was detected. 2.7% of E. faecalis were resistant to norvancomycin.


CONCLUSIONS
It is likely that the observed resistance to third-generation cephalosporins may be partially due to chromosome-mediated type-1 beta- lactamase.
Xu
W
W
Shanghai Burn Institute, Rui Jing Hospital, Shanghai Second Medical University.
Sun
Z
Z
Chen
X
X
D002056:Burns / Q000382:microbiology*; D002438:Cefoperazone / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014946:Wound Infection / Q000382:microbiology
D002511:Cephalosporins; D002443:Ceftriaxone; D002438:Cefoperazone; D002439:Cefotaxime