title: [Experimental study of fibrin glue adhesion with epineurial anchor suture to repair peripheral nerves].
abstract: To prove and improve the technique of fibrin glue adhesion repair peripheral nerve, 20 male rats were chosen. All the rats was randomly divided into two groups: Suture group (n = 10) and glue adhesion group (n = 10). Left sciatic nerves of the rats were cut with knife and repaired by suture or adhesion methods separately according to their groups. When adhesive method being used, the epineurial was fixed with a suture method similar to anchor suture for preventing suture line broken. Immediatly after the repair and 8 weeks after the surgery, the histologic and electrophysiologic changes of the repaired nerve were observed. The result showed: The axonal copation was soon improved in glue adhesion group. At the eighth week, nerve fiber alignment of the adhesion group was more regular than that of the suture group. Moreover, there were great improvement of axon cross rate and the recovery rate of sectional area of nerve fiber at the distal end in glue adhesion group (P < 0.05, P < 0.01). It was concluded that glue adhesion was prior to suture in repair of peripheral nerve, and anchor suture could improve the technique of glue adhesion method.
authors.affiliation: Department of Orthopedic Surgery, Changzheng Hospital, Shanghai, P.R. China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D008297:Male; D009416:Nerve Regeneration; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries* / Q000601:surgery; D013536:Suture Techniques
chemical_list: D015718:Fibrin Tissue Adhesive