[Changes in the proteinase-inhibitor system of rats with hyperlipoproteinemia during transcerebral exposures to a 100-Hz-frequency pulse current and to an ultrahigh-frequency field].
Experiments on 36 male rats with experimental hyperlipoproteinemia demonstrated that transcerebral exposure to impulse current (100 Hz, 2mA) aggravates atherogenic alterations, provokes hyperactivation of kallikrein-kinin system and unbalance of elastase inhibitory activity in the serum and myocardium. The latter may contribute to better vascular permeability for low-density lipoproteins, to development of edema of vascular intima, lability of cellular and lysosomal membranes with hydrolysis of elastine and collagen fibers of myocardial vessels and other organs. Transcerebral exposure to electromagnetic UHF field (40.68 MHz) is not hypolipidemic but has no negative effect on experimental atherosclerosis, promotes normalization of kallikrein-kinin system in the serum, activation of this system in the myocardium and cerebral cortex, correction of destructive processes in the serum and cerebral cortex with a risk of their development in the myocardium.
Zubkova
S M
SM
Varakina
N I
NI
Mikhaĭlik
L V
LV
Chabanenko
S S
SS
D000818:Animals; D001921:Brain / Q000502:physiology; D004599:Electric Stimulation Therapy; D004560:Electricity / Q000009:adverse effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D010450:Endopeptidases / Q000097:blood*; D006951:Hyperlipoproteinemias / Q000201:enzymology* / Q000628:therapy; D016234:Kallikrein-Kinin System / Q000502:physiology; D008297:Male; D011480:Protease Inhibitors / Q000097:blood*; D051381:Rats
D011480:Protease Inhibitors; D010450:Endopeptidases
Izmeneniia v sisteme proteinazy--ingibitory u krys s giperlipoproteidemieĭ pri transtserebral'nykh vozdeĭstviiakh impul'snym tokom s chastotoĭ 100 Gts i ul'travysokochastotnym polem.