[Influence of bioactive glasses on the respiratory burst metabolism of polymorphonuclear neutrophils].
BACKGROUND
Bio-glasses are bioactive materials used to coat implants. The immunological reaction to wear particles from such coatings has hardly been investigated. The generation of reactive oxygen species by polymorphonuclear neutrophils (PMN) on phagocytosis of particles might elicit further immune reactions.


METHODS
The production of reactive oxygen species was investigated in whole blood in the form of chemiluminescence using the probes luminol and lucigenin.


RESULTS
Bioglass particles stimulated PMN to generate free radicals as a function of the bioactivity of the composition. This activation was significantly reduced by prior soaking of the particles. Extracts of the bioactive glasses also inhibited the liberation of free radicals upon the stimulus opsonized zymosan.


CONCLUSIONS
Our results show that despite the proven good biocompatibility of bioactive glasses, further in vivo checks in the early stages of the reaction are needed.
Maitz
M F
MF
Universität Ulm, Abt. Biomaterialien, ZIBMT.
Gabriel
E
E
Franke
R P
RP
D001672:Biocompatible Materials / Q000494:pharmacology; D001843:Bone Cements / Q000494:pharmacology; D002516:Ceramics / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects*
D001672:Biocompatible Materials; C022107:Bioglass; D001843:Bone Cements; D017382:Reactive Oxygen Species
Einfluss von bioaktiven Gläsern auf den Respiratory Burst Metabolismus von Granulozyten.