title: Secondary T-acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia.
abstract: A 34-year-old man with chronic myeloid leukaemia (CML) firstly developed a lymphoid blast crisis of B-cell type. After a second chronic phase which lasted for > 4 years with maintenance chemotherapy of hydroxyurea, 6-mercaptopurine and methotrexate, he developed a T-cell acute lymphoblastic leukaemia of TcR-gammadelta+ type. Cytogenetic analysis revealed disappearance of the t(9;22) translocation and appearance of new abnormalities consistent with the diagnosis secondary acute leukaemia. To our knowledge, secondary leukaemia in CML has not previously been reported.
authors.affiliation: Department of Internal Medicine, Leiden University Medical Centre, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Dawson
authors.forename: R
authors.initials: R
authors.lastname: Slater
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: A W
authors.initials: AW
authors.lastname: Langerak
authors.forename: R
authors.initials: R
authors.lastname: Willemze
authors.forename: J C
authors.initials: JC
authors.lastname: Kluin-Nelemans
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D008297:Male