title: The in vivo and in vitro comparative nephrotoxicity of cefazolin and gentamicin.
abstract: Biochemical, histopathological and cell culture evaluations compared the nephrotoxicity of cefazolin with that of gentamicin. New Zealand rabbits were dosed with 250 mg cefazolin/animal i.m. twice daily, 3 mg gentamicin/kg i.m. twice daily, or 0.9% NaCl solution for 10 d. The rabbits in drug-treated groups had necrosis of proximal kidney tubules and elevated urinary-gamma glutamyl transferase (uGGT) levels. The results of the histopathological examinations, uGGT analyses and effects in cell culture indicated the nephrotoxicities of both antibiotics were similar.
authors.affiliation: Department of Pharmacology and Toxicology, Yuzuncu Yil University, Van, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Yilmaz
authors.forename: M
authors.initials: M
authors.lastname: Cabalar
authors.forename: S
authors.initials: S
authors.lastname: Ozbilgin
mesh_terms: D000818:Animals; D002417:Cattle; D002437:Cefazolin / Q000633:toxicity*; D002478:Cells, Cultured; D002511:Cephalosporins / Q000633:toxicity*; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects*; D011817:Rabbits
chemical_list: D002511:Cephalosporins; D005839:Gentamicins; D002437:Cefazolin