[Early corneal limbal autograft transplantation after alkali burns].
OBJECTIVE
To understand the clinical significance of corneal limbus transplantation on alkali burns.


METHODS
14 New Zealand rabbits were used, 1.0 mol/L NaOH solution was placed on the anterior surface of the eyes for 1 minute. Limbal autograft transplantation was performed on 7 rabbits immediately after the burn. The other 7 rabbits were used as controls. The follow-up period lasted for 1 month and then the histopathological changes of corneas were observed under light and scanning electron microscopes.


RESULTS
Faster corneal epithelial healing, less corneal neovascularization and inflammatory cell infiltration occurred in the operative group.


CONCLUSIONS
Early limbal autograft transplantation can accelerate corneal epithelial healing, restrain corneal neovascularization and inflammatory response, therefore it can prevent corneal ulceration.
Chen
J
J
Department of Ophthalmology, Medical College, Jinan University, Guangzhou.
Xu
J
J
D000818:Animals; D002057:Burns, Chemical / Q000601:surgery*; D003315:Cornea / Q000648:ultrastructure; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000517:prevention & control; D005126:Eye Burns / Q000139:chemically induced / Q000601:surgery*; D005260:Female; D016850:Limbus Corneae; D008297:Male; D011817:Rabbits; D014182:Transplantation, Autologous