title: Non-cardiac adverse effects of antihistamines (H1-receptor antagonists).
abstract: Antihistamines, available without prescription in many countries, are generally considered to be safe medications; however, the old first-generation H1 antagonists commonly cause adverse central nervous system (CNS) effects, even when administered in usual doses. Patients may not be aware of these effects and do not necessarily develop tolerance to them. In contrast, the new, second-generation H1 antagonists are relatively free from adverse effects in the CNS, primarily because they do not cross the blood-brain barrier and block the important neurotransmitter function of histamine. Most of the H1 antagonists in current use are unlikely to cause cardiac toxicity. There is no evidence that H1 antagonists, which have been approved by regulatory agencies, have carcinogenic, tumour-promoting, or teratogenic effects in humans.
authors.affiliation: Section of Allergy and Clinical Immunology, Department of Paediatrics and Child Health, University of Manitoba, Manitoba, Canada.
authors.forename: F E
authors.initials: FE
authors.lastname: Simons
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced
chemical_list: D006634:Histamine H1 Antagonists