Induction of apoptosis and inhibition of cellular proliferation as a dual approach to treatment of ovarian cancer.
Inhibition of mitosis or induction of apoptosis are pathways at which anti tumour therapies could be aimed. This study evaluates the actions of CGP52411 (cell growth inhibitor) and transforming growth factor beta1 (TGFbeta1) (inducer of apoptosis) alone and in combination on two ovarian carcinoma cell lines (PEO1 and OVCAR3). In both cell lines TGFbeta1 treatment increased the level of apoptotic cells and CGP52411 treatment reduced EGF stimulated cell growth. Combined treatment further reduced cell numbers in PEO1 cultures, demonstrating that dual therapy aimed at both aspects of cell regulation has a greater anti tumour action.
Edwards
J
J
University Department of Surgery, Queen Elizabeth Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, UK.
Bartlett
J M
JM
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D010797:Phthalimides / Q000627:therapeutic use; D011493:Protein Kinase C / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010797:Phthalimides; D016212:Transforming Growth Factor beta; D066246:ErbB Receptors; D011493:Protein Kinase C; C098874:4,5-dianilinophthalimide