[Bone mineral density in patients with cystic fibrosis by dual-energy X-ray absorptiometry].
BACKGROUND
The aim of this study was to assess the bone mineral density of cystic fibrosis patients.


METHODS
We have retrospectively studied 45 patients with cystic fibrosis, 22 females and 23 males, aged between six and 27 years (mean 13 +/- 5.5 years). Nutritional status, Shwachman score, pulmonary function, serum calcium and 25-hydroxyvitamin D levels and lumbar bone mineral density by dual energy X-ray absorptiometry were assessed.


RESULTS
The average height of the patients was 97 +/- 4% (range: 86-106) and body mass index 93 +/- 10% (range 77-114) of the normal values of age. The average Shwachman score was 80 +/- 11/100 (range: 47-96). The forced expiratory volume in 1s was 80 +/- 29% (21-128) and the vital capacity 85 +/- 21% (range: 40-122) of the predicted values. The serum levels of calcium and 25-hydroxyvitamin D were lower than normal values in six cases and one case respectively. Thirty-eight patients had a mean lumbar spine bone mineral Z-score which was -1.35 +/- 1.2 DS and 84.7 +/- 13.5% of the normal values. It was correlated with the height, the body mass index, the Shwachman score, the FEV 1 and the vital capacity.


CONCLUSIONS
Decreased bone density is frequent among cystic fibrosis subjects. It shows a lack of control of the illness. It remains unknown with usual investigation; the dual X-ray absorptiometry should, each time it is possible, take part of investigations in those patients.
Duveau
E
E
Département de pédiatrie, CHU d'Angers, France.
Beringue
F
F
Pellier
I
I
Audran
M
M
Ginies
J L
JL
D015502:Absorptiometry, Photon / Q000379:methods*; D000293:Adolescent; D000328:Adult; D001827:Body Height; D015519:Bone Density; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D012189:Retrospective Studies
D002112:Calcifediol; D002118:Calcium
Etude de la minéralisation osseuse de patients mucoviscidosiques par absorptiométrie biphotonique à rayons X.