[Evaluation of antimycotics in the elderly].
Incidence and risk factors were analyzed in elderly patients with deep-seated mycosis. Twenty cases with candidiasis or aspergillosis were found in 1,663 autopsy cases. Intravascular catheters and administration of antibiotics were prominent risk factors for candidiasis as was steroid therapy. Leukocytopenia due to anti-cancer drugs caused aspergillosis. Preventive use of AMPH in patients with hematological malignancies or with steroid therapy was effective against mycosis. Although AMPH is also effective for almost all kinds of deep-seated mycosis, we rarely administered it to elderly patients because of its nephrotoxicity. The safe use of antimycotics requires checking drug sensitivity of causative fungi in a laboratory, and establishing the optimal dosage for patients with impaired renal function.
Fukayama
M
M
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital, Japan.
D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000517:prevention & control; D012307:Risk Factors
D000935:Antifungal Agents; D000666:Amphotericin B