[Comparative studies of particle distribution range of aerosol cromolyn sodium generated by MDI systems].
Particles size distribution of the sodium cromoglycate preparations: CROPOZ PLUS and CROMOGEN EB generated with MDI and for under-pressure releasing methods were measured. Results of measurements indicate a significant repeatability of each sample properties. An average contribution of mass of the respirable fraction for both aerosolized pharmaceuticals is in the range of 40% of the generated dose. CROMOGEN EB with optimizer (spacer) gives a higher contribution of the respirable fraction--up to 50% of dose, with simultaneous lower value of the released mass of aerosol. Particles size distribution of CROPOZ PLUS within a respirable fraction indicates an efficient penetration and deposition of particles in the upper, central and peripheral parts of tracheobronchial tree (TB). High contribution of submicron particles of CROMOGEN EB with optimizer gives efficient penetration and deposition of these particles in the lungs.
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Zakładu Procesów Podstawowych i Ochrony Srodowiska Wydziału Inzynierii Chemicznej i Procesowej Politechniki Warszawskiej. gradon@ichip.pw.edu.pl
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D000280:Administration, Inhalation; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008168:Lung / Q000378:metabolism; D010316:Particle Size; D014132:Trachea / Q000378:metabolism
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D004205:Cromolyn Sodium
Badania porównawcze rozkładów wielkości czastek aerozolowych kromoglikanu dwusodowego generowanych z dozowników MDI.