title: Iron fortified follow on formula from 9 to 18 months improves iron status but not development or growth: a randomised trial.
abstract: OBJECTIVE
  Iron deficiency anaemia is associated, in observational studies, with developmental disadvantage. This study tested the hypothesis that feeding iron supplemented formula from 9 to 18 months of age would improve developmental performance.
  
  
  METHODS
  493 healthy children aged 9 months being fed pasteurised cows' milk were recruited from three UK centres. They were randomised to: cows' milk as before, formula containing 0.9 mg/litre iron, or formula containing 1.2 mg/litre iron, until 18 months of age. Bayley mental and psychomotor developmental indices were measured at 18 months, as were growth and haematological indices.
  
  
  RESULTS
  Children fed iron fortified formula had higher plasma ferritin concentrations, but there were no significant intergroup differences in development or growth.
  
  
  CONCLUSIONS
  There are no developmental or growth advantages in children given iron supplemented formula, but a benefit for a minority who were anaemic, or the possibility that a benefit may emerge at a later age, cannot be excluded.
authors.affiliation: Menzies Centre for Population Health Research, Tasmania and Clinical Epidemiology and Biostatistics Unit, University of Melbourne Department of Paediatrics, Royal Children's Hospital, Parkville, VIC 3052, Australia. morleyr@cryptic.rch.unimelb.edu.au
authors.forename: R
authors.initials: R
authors.lastname: Morley
authors.forename: R
authors.initials: R
authors.lastname: Abbott
authors.forename: S
authors.initials: S
authors.lastname: Fairweather-Tait
authors.forename: U
authors.initials: U
authors.lastname: MacFadyen
authors.forename: T
authors.initials: T
authors.lastname: Stephenson
authors.forename: A
authors.initials: A
authors.lastname: Lucas
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000517:prevention & control; D000818:Animals; D000886:Anthropometry; D002657:Child Development / Q000187:drug effects*; D005260:Female; D005293:Ferritins / Q000097:blood; D005527:Food, Fortified; D006128:Growth / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D019266:Iron, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008892:Milk; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D006454:Hemoglobins; D019266:Iron, Dietary; D005293:Ferritins