title: A novel method of endoscopic mucosal resection using sodium hyaluronate.
abstract: BACKGROUND
  Saline-assisted endoscopic mucosal resection is an established therapeutic method. However, it is sometimes difficult to maintain a desired level of tissue elevation after injection of saline. Therefore we decided to use a mucinous substance such as sodium hyaluronate instead of saline.
  
  
  METHODS
  Two resected porcine stomachs and five dogs were used for the study. The elevations, made by submucosal injections of sodium hyaluronate, were compared with those produced with normal saline. Sodium hyaluronate-assisted mucosal resections were compared with the saline-assisted resections.
  
  
  RESULTS
  Mucosal elevations created by submucosal injections of sodium hyaluronate remained for a longer time with a clearer margin compared to those made by saline injection. Endoscopic mucosal resections were performed safely with the assistance of sodium hyaluronate.
  
  
  CONCLUSIONS
  Use of sodium hyaluronate instead of saline for endoscopic mucosal resection could make the procedure easier and more reliable.
authors.affiliation: Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Yube
authors.forename: N
authors.initials: N
authors.lastname: Isoda
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Sekine
authors.forename: T
authors.initials: T
authors.lastname: Higashizawa
authors.forename: K
authors.initials: K
authors.lastname: Ido
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Kanai
mesh_terms: D000818:Animals; D004285:Dogs; D004724:Endoscopy / Q000379:methods*; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007267:Injections; D009336:Necrosis; D011127:Polyps / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D012965:Sodium Chloride / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery; D013552:Swine; D016896:Treatment Outcome
chemical_list: D012965:Sodium Chloride; D006820:Hyaluronic Acid