The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.
The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
van der Houven van Oordt
C W
CW
Department of Molecular Carcinogenesis, Leiden University, The Netherlands.
Smits
R
R
Schouten
T G
TG
Houwing-Duistermaat
J J
JJ
Williamson
S L
SL
Luz
A
A
Meera Khan
P
P
van der Eb
A J
AJ
Breuer
M L
ML
Fodde
R
R
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000818:Animals; D004814:Epidermal Cyst / Q000235:genetics; D005260:Female; D018222:Desmoid Tumors / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D019656:Loss of Heterozygosity / Q000235:genetics; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000235:genetics; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics; D014965:X-Rays