Is sleeping sickness a circadian disorder? The serotonergic hypothesis.
Patients with human African trypanosomiasis (HAT, sleeping sickness), due to the inoculation of Trypanosoma brucei gambiense or rhodesiense by the tsetse fly, are "sleepy by day and restless by night." The first 24 h polysomnographic recording (electroencephalogram [EEG], electromyogram [EMG], electrooculogram [EOG]), showing a disappearance of the 24 h rhythmicity of sleep and wakefulness, was performed in 1988. Thereafter, our team recorded 18 patients and 6 control volunteers at bed rest during 24 h sessions. Blood samples were taken hourly from 8 of the patients through a venous catheter and every 10 minutes from the remaining 10 patients. Plasma cortisol, prolactin, growth hormone (GH), melatonin, and plasma renin activity were analyzed. No disruptions of the circadian rhythms of sleep and wakefulness were described in the 6 healthy African subjects, and there also were no disturbances of 24 h hormone profiles. The patients experienced a dysregulation of the circadian rhythmicity of sleep and wakefulness that was proportional to the severity of the disease. Sleep onset rapid eye movement (REM) episodes were more frequent in the most severely sick patients, who also showed major disruptions in the 24 h plasma hormonal profiles, with intermediate profiles being observed at earlier stages of the sickness. However, the relationship between hormonal secretions and the states of vigilance persisted. Contrary to the other hormones, melatonin secretion remained undisturbed. These findings indicate that, at the stage of meningoencephalitis, HAT represents a dysregulation of the sleep-wake cycle and sleep structure, rather than a hypersomnia; this dysregulation is proportional to the degree of severity of the clinical and biological symptoms. It is accompanied by a circadian dysrhythmia of hormonal secretions, although the relationship between hormone pulses and sleep states is preserved. We therefore favor the involvement of the serotonergic raphe nuclei-suprachiasmatic nuclei liaison in the reversible disturbance of the circadian rhythms of the sleep-wake cycle and of hormonal secretions.
Buguet
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Département des Facteurs Humains, Centre de Recherches du Service de Santé des Armées Emile Pardé, La Tronche, France. a.buguet@alpes-net.fr
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D006728:Hormones / Q000097:blood; D006801:Humans; D008549:Melarsoprol / Q000627:therapeutic use; D008550:Melatonin / Q000097:blood; D008590:Meningoencephalitis / Q000188:drug therapy / Q000503:physiopathology; D008954:Models, Biological; D011903:Raphe Nuclei / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D013493:Suprachiasmatic Nucleus / Q000503:physiopathology; D014344:Trypanocidal Agents / Q000627:therapeutic use; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000503:physiopathology*
D006728:Hormones; D014344:Trypanocidal Agents; D012701:Serotonin; D008550:Melatonin; D008549:Melarsoprol