title: Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic.
abstract: Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8(+) cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.
authors.affiliation: Saint Louis University School of Medicine, Department of Molecular Microbiology and Immunology, 1402 South Grand Boulevard, St Louis, MO 63104, USA. woldws@slu.edu
authors.forename: W S
authors.initials: WS
authors.lastname: Wold
authors.forename: K
authors.initials: K
authors.lastname: Doronin
authors.forename: K
authors.initials: K
authors.lastname: Toth
authors.forename: M
authors.initials: M
authors.lastname: Kuppuswamy
authors.forename: D L
authors.initials: DL
authors.lastname: Lichtenstein
authors.forename: A E
authors.initials: AE
authors.lastname: Tollefson
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D017500:Adenovirus E1A Proteins / Q000502:physiology; D017501:Adenovirus E1B Proteins / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D015316:Genetic Therapy; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D017500:Adenovirus E1A Proteins; D017501:Adenovirus E1B Proteins; D015395:Histocompatibility Antigens Class I