title: Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?
abstract: Several 1-deazapurine nucleosides were tested for their biological activity, anti-HIV-1, cytotoxicity and inhibition of adenosine deaminase (ADA). A2780 human ovarian cancer cells and the deoxycytidine kinase (dCK) deficient variant AG6000, used to determine whether dCK plays a role in their activation, showed a similar sensitivity to the analogs. This is in line with substrate specificity tests, which revealed a very low affinity of dCK.
authors.affiliation: Dept. Oncology, University Hospital VU, Amsterdam, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Bergman
authors.forename: G
authors.initials: G
authors.lastname: Cristalli
authors.forename: S
authors.initials: S
authors.lastname: Vittori
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: G J
authors.initials: GJ
authors.lastname: Peters
mesh_terms: D058892:Adenosine Deaminase Inhibitors; D001372:Aza Compounds / Q000737:chemistry; D002455:Cell Division; D003842:Deoxycytidine Kinase / Q000378:metabolism*; D005260:Female; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology; D011684:Purine Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
chemical_list: D058892:Adenosine Deaminase Inhibitors; D001372:Aza Compounds; D011684:Purine Nucleosides; D003842:Deoxycytidine Kinase