Endothelin release by capsaicin in isolated working rat heart.
Capsaicin (1 nM-1 microM) induced a concentration-dependent decrease in heart rate, coronary flow, aortic flow, left ventricular developed pressure and its first derivative, dP/dt(max) in isolated working rat heart. The effect of 10 nM capsaicin was mimicked by 0.1 nM endothelin. PD142893 (200 nM), a non-selective endothelin receptor blocking agent antagonized the effect of either endothelin (0.1 nM) or capsaicin (10 nM). We conclude that the majority of the effects of capsaicin in the rat heart are mediated by neural endothelin release.
Szolcsányi
J
J
Department of Pharmacology and Pharmacotherapy, University Medical School of Pécs, Pecs, Hungary. szolcs@apacs.pote.hu
Oroszi
G
G
Németh
J
J
Szilvássy
Z
Z
Tósaki
A
A
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000494:pharmacology*; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002317:Cardiovascular Agents; D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D009842:Oligopeptides; C076213:PD 142893; D002211:Capsaicin