Evaluation of the effects of desmopressin in acute ureteral obstruction.
OBJECTIVE
To evaluate the effects of desmopressin on pressure values inside the pelvis and ureter of the rat following acute obstruction.


METHODS
By means of a microsurgical technique, 24 male Wistar rats were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginning of the experiment.


RESULTS
Rats pretreated with desmopressin showed a statistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05).


CONCLUSIONS
In Wistar rats desmopressin demonstrated a powerful antidiuretic effect, reducing the intraureteral pressure. The experimental model is useful for a better understanding of physiopathology of renal colic and acute obstruction.
Moro
U
U
Department of Urology, Udine University, Udine, Italy.
De Stefani
S
S
Crisci
A
A
De Antoni
P
P
Scott
C A
CA
Selli
C
C
D000208:Acute Disease; D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010388:Pelvis / Q000503:physiopathology; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D012076:Renal Agents / Q000494:pharmacology*; D015203:Reproducibility of Results; D014513:Ureter / Q000187:drug effects* / Q000503:physiopathology; D014517:Ureteral Obstruction / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin