title: Distinct B-cell populations are present in hepatic and intestinal Schistosoma mansoni granulomas.
abstract: Although it is generally accepted that schistosomal granuloma formation results from a T-cell dependent host response towards the parasite egg, attention has recently been focused on the involvement of B-cells in the induction of schistosome-induced pathology. In this study we investigated the involvement of two functionally different B-cell populations in the formation of the Schistosoma mansoni granuloma: naive and antigen-stimulated B-cells. In liver granulomas two distinct B-cell populations were found, namely unstimulated B-cells at the periphery of the granuloma and antigen-stimulated, syndecan-1 positive B-cells in the inner part near the deposited egg. Intestinal granulomas differed by their relative lack of unstimulated B-cells at the granuloma periphery, but like hepatic granulomas intestinal granulomas also have syndecan-1 positive B-cells. From our results, we conclude that B-cells are important constituents of the S. mansoni granuloma.
authors.affiliation: Department of Pathology, University of Antwerp (U.I.A.), Vlaanderen.
authors.forename: W
authors.initials: W
authors.lastname: Jacobs
authors.forename: J
authors.initials: J
authors.lastname: Bogers
authors.forename: E
authors.initials: E
authors.lastname: Van Marck
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000473:pathology*; D019013:CD40 Antigens / Q000032:analysis; D006099:Granuloma / Q000469:parasitology / Q000473:pathology; D008109:Liver Diseases, Parasitic / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D051379:Mice; D011509:Proteoglycans / Q000032:analysis; D012555:Schistosomiasis mansoni / Q000473:pathology*; D053668:Syndecan-1; D053667:Syndecans
chemical_list: D019013:CD40 Antigens; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508242:Sdc1 protein, mouse; D053668:Syndecan-1; D053667:Syndecans