Left atrial systolic time interval in hyperthyroidism.
The author noninvasively examined effects of thyroid hormone on left atrial function by using the left atrial systolic time intervals (LASTI) with its parameters as left atrial ejection time (LAET), left atrial preejection period (LAPEP), and LAET/LAPEP, as measured by pulsed Doppler echocardiography. The hyperthyroid (HTH) and normal control (NC) groups consisted of 21 and 25 subjects, respectively. He also considered serum triiodothyronine (T3) concentrations, age, heart rate, systolic blood pressure, left ventricular preload, afterload, contractility, diastolic function, P wave duration, PR interval, and left ventricular preejection period (LVPEP) as factors that might influence LASTI. LAET, LAET/LAPEP, and LVPEP in the HTH group were significantly shorter than in the NC group. LAET showed no significance with serum T3 concentration, but did with LVPEP in partial correlation analysis. These results demonstrated that a short LAET in the hyperthyroid state is controlled by a rapid rise in the left ventricular pressure.
Dazai
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Department of Internal Medicine, Ehime Prefectural Kitauwa Hospital, Japan.
D000328:Adult; D000367:Age Factors; D013956:Antithyroid Agents / Q000627:therapeutic use; D016279:Atrial Function, Left / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood / Q000502:physiology; D013974:Thyroxine / Q000097:blood / Q000502:physiology; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology; D017725:Ventricular Pressure / Q000502:physiology
D013956:Antithyroid Agents; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine