title: Parainfluenza virus infection among adults hospitalized for lower respiratory tract infection.
abstract: To better define the contribution of human parainfluenza viruses (HPIVs) to lower respiratory tract infection in adults, we tested acute- and convalescent-phase serum specimens from hospitalized adults participating in a population-based prospective study of lower respiratory tract infection during 1991-1992. We tested all available specimens from the epidemic seasons for each virus and approximately 300 randomly selected specimens from the corresponding off-seasons for antibodies to HPIV-1, HPIV-2, or HPIV-3. During the respective epidemic season, HPIV-1 infection was detected in 18 (2.5%) of 721 and HPIV-3 infection in 22 (3.1%) of 705 patients with lower respiratory tract infection. Only 2 (0.2%) of 1,057 patients tested positive for HPIV-2 infection. No HPIV-1 infections and only 2 (0.7% of 281 patients tested) HPIV-3 infections were detected during the off-seasons. HPIV-1 and HPIV-3 were among the four most frequently identified infections associated with lower respiratory tract infection during their respective outbreak seasons.
authors.affiliation: Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
authors.forename: A
authors.initials: A
authors.lastname: Marx
authors.forename: H E
authors.initials: HE
authors.lastname: Gary
authors.forename: B J
authors.initials: BJ
authors.lastname: Marston
authors.forename: D D
authors.initials: DD
authors.lastname: Erdman
authors.forename: R F
authors.initials: RF
authors.lastname: Breiman
authors.forename: T J
authors.initials: TJ
authors.lastname: Török
authors.forename: J F
authors.initials: JF
authors.lastname: Plouffe
authors.forename: T M
authors.initials: TM
authors.lastname: File
authors.forename: L J
authors.initials: LJ
authors.lastname: Anderson
mesh_terms: D000328:Adult; D004196:Disease Outbreaks; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D010222:Parainfluenza Virus 1, Human / Q000276:immunology; D010223:Parainfluenza Virus 2, Human / Q000276:immunology; D010224:Parainfluenza Virus 3, Human / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D010351:Patient Discharge; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D011446:Prospective Studies