Role of cholecystokinin type B receptors in ultrasound induced behavior in rats.
The cholecystokinin-tetrapeptide (CCK-4) can induce panic attacks in humans. The present study investigates the effects of CCK-4 and the CCK-B receptor antagonist L-365.260 on ultrasound induced defense behavior in the rat that may model the unconditioned aspects of panic behavior in man. CCK-4 (50 microg/kg) increased the defense response induced by ultrasound (95 dB) an effect prevented by pretreatment with L-365.260 (10 microg/kg). Compared with other antipanic/panicogenic drugs the effects of CCK-4 and L-365.260 were relatively small. In conclusion, drugs acting at the CCK-B receptor appear to have only a minor role in the modulation of an unconditioned aversive response.
Voits
M
M
Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University, Berlin, Germany. voits@charite.de
Beckett
S R
SR
Marsden
C A
CA
Fink
H
H
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D004336:Drug Antagonism; D004924:Escape Reaction / Q000502:physiology*; D006801:Humans; D008297:Male; D010671:Phenylurea Compounds / Q000494:pharmacology; D051381:Rats; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology*; D013016:Sound; D013758:Tetragastrin / Q000494:pharmacology
D001570:Benzodiazepinones; D010671:Phenylurea Compounds; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C058121:L 365260