title: Efficacy, safety and toleration of fluconazole suppositories in the treatment of oral candidosis.
abstract: An open multicentre, non-comparative study was conducted in three countries to investigate the efficacy, safety and tolerance of fluconazole suppositories in the treatment of oropharyngeal candidosis. Patients received fluconazole 100 mg day-1 in the form of suppositories or capsules. Minimum duration of total treatment was 7 days, maximum total treatment duration was 14 days, and median duration of total treatment was 9.5 (7-14) days. After having received suppository-based treatment for at least 5 days, patients could be switched to oral treatment. Eighty-two male and 19 female patients with a mean age of 43 years were enrolled in the study. The median duration of suppository treatment was 8.9 (5-14) days. Patients were evaluated clinically and mycologically at regular intervals during and at the end of treatment. Seventy-nine of 101 patients enrolled in the study were considered efficacy-evaluable. Clinical cure was achieved in 75 of 79 (95%) patients and improvement was seen in four of 79 (5%) at the end of therapy. At follow-up after 1 month, clinical cure was observed in 48 of 63 (76%) patients. The results of this study demonstrates that the fluconazole suppository formulation is effective, safe and well tolerated.
authors.affiliation: St. Georg General Hospital, Hamburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Plettenberg
authors.forename: A
authors.initials: A
authors.lastname: Stoehr
authors.forename: W
authors.initials: W
authors.lastname: Heise
authors.forename: F
authors.initials: F
authors.lastname: Schlote
authors.forename: E
authors.initials: E
authors.lastname: Sarnow
authors.forename: M
authors.initials: M
authors.lastname: Migdal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002180:Candidiasis, Oral / Q000628:therapy*; D002214:Capsules; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology; D013488:Suppositories / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D002214:Capsules; D013488:Suppositories; D015725:Fluconazole