title: [The pathogenetic characteristics and the possible ways for the pharmacological correction of insulin-dependent diabetes mellitus].
abstract: This work reflects the modern concepts of the pathogenesis of insulin-dependent diabetes mellitus and the prospective trends of pharmacological correction, analyzes the possibility of including in the therapeutic complex antiviral drugs, immunocorrecting measures, antioxidants, inhibitors of aldose reductase, amino guanidine, SH-group donors, and new medicamentous forms of insulin. Problems of an individual choice of drugs with consideration for the stage-development of the disease, the main pathogenetic mechanisms, the chronobiological rhythm of drug prescription, and adequate control of the efficacy of the applied pharmacotherapy are discussed.
authors.affiliation: Department of Clinical Pharmacology, Voronezh State Medical Academy, Russia.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Chernov
authors.forename: A N
authors.initials: AN
authors.lastname: Pashkov
authors.forename: M V
authors.initials: MV
authors.lastname: Vasin
authors.forename: G A
authors.initials: GA
authors.lastname: Batishcheva
authors.forename: D V
authors.initials: DV
authors.lastname: Zolotarev
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D002940:Circadian Rhythm; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D014777:Virus Diseases / Q000150:complications
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
vernacular_title: Osobennosti patogeneza i vozmozhnye puti farmakologicheskoĭ korrektsii insulinzavisimoogo sakharnogo diabeta.