Sexual development in a two-year-old boy induced by topical exposure to testosterone.
Virilization, including penile enlargement and growth of pubic hair and facial acne, developed in a 2-year-old boy over a period of months. This sexual development was induced by incidental and unintentional dermal exposure to a testosterone cream that was applied to his father's arm and back as a part of body building regimen. Except for penile size, the other signs of virilization diminished several months after the exposure was discontinued.
Yu
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YM
Division of Pediatric Endocrinology, Department of Pediatrics, University of North Carolina, Chapel Hill, North Carolina 27599-7220, USA. ymy62@med.unc.edu.com
Punyasavatsu
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N
Elder
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D'Ercole
A J
AJ
D000287:Administration, Topical; D002675:Child, Preschool; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000139:chemically induced*; D013739:Testosterone / Q000009:adverse effects*
D013739:Testosterone