[Crystalline keratopathy as a presenting sign of multiple myeloma].
BACKGROUND
Noninfectious crystalline corneal degenerations can be classified from the clinical and genetical point of view into 3 groups: 1. primary hereditary (Schnyder), 2. secondary hereditary (cystinosis) and 3. secondary non-hereditary in association with disorders of serum protein or lipid composition.


METHODS
We report on a 63-year-old man with reduced vision and grey-white, crystalline, monomorpheous deposits in the corneal stroma. Further investigation revealed IgG myeloma.


RESULTS
We performed a penetrating keratoplasty for visual improvement. On histopathological examination, typical eosinophilic, PAS-positive, interlamellar deposits staining brilliant red with Masson's trichrome were found diffusely scattered throughout the stroma. Electron microscopy showed intracellular, rhomboid-shaped deposits enveloped by a membrane.


CONCLUSIONS
The appearance of a crystalline keratopathy should be followed by an internal examination for early detection and adequate treatment of a systemic disease.
Gabel
J
J
Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg.
Seitz
B
B
Hantsch
A
A
Naumann
G O
GO
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002614:Chelating Agents / Q000627:therapeutic use; D003315:Cornea / Q000648:ultrastructure; D003316:Corneal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D000080027:Cyclams; D006571:Heterocyclic Compounds / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G; D015948:Keratoplasty, Penetrating / Q000379:methods; D007908:Lens, Crystalline / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012162:Retinal Degeneration / Q000175:diagnosis
D018931:Antineoplastic Agents, Hormonal; D002614:Chelating Agents; D000080027:Cyclams; D006571:Heterocyclic Compounds; D007074:Immunoglobulin G; C038072:cyclen; D011239:Prednisolone
Kristalline Keratopathie als Erstsymptom eines Plasmozytoms.