Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype.
Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.
Gröschel
B
B
Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., Germany.
Meier
C
C
Zehner
R
R
Cinatl
J
J
Doerr
H W
HW
Cinatl
J
J
D019380:Anti-HIV Agents / Q000494:pharmacology; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D004352:Drug Resistance, Microbial; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018119:Stavudine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013937:Thymidine Kinase / Q000235:genetics; D015215:Zidovudine / Q000494:pharmacology*
D019380:Anti-HIV Agents; D017931:DNA Primers; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D018119:Stavudine; D013937:Thymidine Kinase