title: Mechanisms of vesicle formation: insights from the COP system.
abstract: The major cytosolic and membrane proteins that represent machinery of coat protein (COP)-coated transport vesicles within the secretory pathway are characterized to date. This has allowed investigation of the molecular mechanisms that underlie the formation of these vesicles. In vitro binding studies and reconstitution experiments have provided insights at the molecular level into the biogenesis of COPII- and COPI-coated vesicles.
authors.affiliation: Biochemie-Zentrum Heidelberg (BZH), Ruprecht-Karls-Universität, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany. felix.wieland@urz.uni-heidelberg.de
authors.forename: F
authors.initials: F
authors.lastname: Wieland
authors.forename: C
authors.initials: C
authors.lastname: Harter
mesh_terms: D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000818:Animals; D002213:Capsid / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D020755:Coat Protein Complex I / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008081:Liposomes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism
chemical_list: D020755:Coat Protein Complex I; D008081:Liposomes; D008565:Membrane Proteins; D006160:Guanosine Triphosphate; D020727:ADP-Ribosylation Factors