Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia.
Zhenxuanyin [symbol: see text] is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes' complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03 g/kg, 0.3 g/kg, 1 g/kg, or 3 g/kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3 g/kg can increase cerebral blood flow (CBF) to the normal level.
Jingyi
W
W
Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
Yasuhiro
M
M
Naoya
H
H
Seok
R C
RC
Yoshiharu
Y
Y
Nagara
T
T
Fumiko
T
T
Shigeru
M
M
Junji
K
K
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D020367:Iofetamine; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014715:Vertebrobasilar Insufficiency / Q000503:physiopathology*
D004365:Drugs, Chinese Herbal; D020367:Iofetamine