Thymidine phosphorylase activity and angiogenesis in gastric cancer.
Angiogenesis has an important role in the growth and metastasis of solid tumors. Several angiogenic factors have been identified, one being platelet-derived endothelial cell growth factor (PD-ECGF), which is identical to thymidine phosphorylase (dThdPase). We investigated the activity of dThdPase in 84 samples of 42 human gastric cancers, by liquid chromatography. The dThdPase activity significantly correlated to the microvessel density assessed by immunostaining to CD-31 antigen (P<0.05). Expression of dThdPase has an important role in the promotion of angiogenesis in human gastric cancer.
Kakeji
Y
Y
Department of Surgery II, Faculty of Medicine, Kyushu University, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Maehara
Y
Y
Tomoda
M
M
Kabashima
A
A
Oda
S
S
Ooshiro
T
T
Baba
H
H
Kohnoe
S
S
Sugimachi
K
K
D000328:Adult; D000368:Aged; D002853:Chromatography, Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000201:enzymology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000201:enzymology*; D013939:Thymidine Phosphorylase / Q000378:metabolism*
D019408:Platelet Endothelial Cell Adhesion Molecule-1; D013939:Thymidine Phosphorylase