title: Conservative medical and surgical management of interstitial ectopic pregnancy.
abstract: OBJECTIVE
  To review the definition and diagnosis of interstitial and heterotopic interstitial pregnancy and to evaluate the conservative management of these conditions.
  
  
  METHODS
  A MEDLINE computer search was used to identify relevant studies. The mean values for the duration of amenorrhea, serum beta-hCG level, size of the ectopic mass, and success rates of the various treatment modalities were calculated from the raw data in the original publications.
  
  
  RESULTS
  A review of 41 patients with interstitial pregnancy who were treated with methotrexate systemically, locally, or in combination revealed an overall success rate of 83%. The mean duration of amenorrhea, mean serum beta-hCG level, and mean size of the ectopic mass were 54 days, 15,127 mIU/mL, and 23 mm, respectively. Among 22 patients with interstitial pregnancy who were treated with conservative laparoscopic techniques, the overall success rate was 100%. In this group, the mean duration of amenorrhea, mean serum beta-hCG level, and mean size of the ectopic mass were 54 days, 7,572 mIU/mL, and 31 mm, respectively. There were nine cases of heterotopic interstitial pregnancy. Seven patients were managed with potassium chloride injected into the ectopic pregnancy, and two patients were treated by laparoscopy. Overall, 67% of the coexisting intrauterine pregnancies resulted in successful deliveries and the remainder ended in spontaneous abortions.
  
  
  CONCLUSIONS
  Cornual resection or hysterectomy with a laparotomy should no longer be the first line of treatment for a hemodynamically stable patient with an interstitial pregnancy. In selected cases, methotrexate and laparoscopy can be used successfully in treating early interstitial pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Lau
authors.forename: T
authors.initials: T
authors.lastname: Tulandi
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D016239:MEDLINE; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D011271:Pregnancy, Ectopic / Q000453:epidemiology / Q000601:surgery / Q000628:therapy*; D014481:United States; D014597:Uterine Rupture
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate