[Growth and collagen synthesis disorders in asthmatic children treated with inhaled steroids].
We report the case of an atopic patient aged 16 with a perannual asthma. He has been treated since the age of 4 with inhaled corticosteroïds. His growth was regular until he was 14 when beclomethasone was replaced by fluticasone (both administered by pressurized inhaler) due to adrenal suppression. Growth inhibiting effects of different inhaled corticosteroids are discussed focusing mainly on their effect on collagen synthesis.
Martin-du Pan
R C
RC
Vonlanthen
M C
MC
Dubuis
J M
JM
D000280:Administration, Inhalation; D000293:Adolescent; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects*; D003094:Collagen / Q000096:biosynthesis* / Q000187:drug effects*; D000068298:Fluticasone; D006130:Growth Disorders / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D008297:Male
D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D003094:Collagen; D000068298:Fluticasone; D001507:Beclomethasone
Troubles de la croissance et de la synthèse du collagène chez des enfants asthmatiques traités par des stéroïdes en inhalation.