[The neurotropic effect of aplegin (carnitine) in cerebral hypoxia].
Intravenously injected aplegin (carnitine) competitively displacing glucose, includes metabolic shunt of fatty acids, the activity for which was determined by the presence of free carnitine and was not limited by oxygen unlike the aerobic glycolysis. This effect may have paramount importance in acute hypoxia of the brain, and in some other critical conditions. Carnitine has a potent neurotrophic activity. Thus, it inhibits development of apoptosis, limits the area of damage and restores structure of nervous tissue.
Kuzin
B M
BM
Kolesnikova
T I
TI
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002331:Carnitine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006613:Higher Nervous Activity / Q000187:drug effects; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000378:metabolism; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002491:Central Nervous System Agents; D002331:Carnitine
Neĭrotroficheskoe vliianie aplegina (karnitina) pri gipoksii golovnogo mozga.