Powder diffractometric assay of two polymorphic forms of ranitidine hydrochloride.
A simple X-ray powder diffractometric method was developed for the qualitative and quantitative assay of the two crystalline modifications of ranitidine-HCl. The main purpose of the present work was to investigate if artificial neural networks (ANNs) could be applied in quantitative X-ray diffractometric analyses. The ANN approach was compared with a conventional mixture design method. The results obtained by the ANN had a smaller standard deviation and relative error and a better precision at lower concentrations. ANNs provide a simple alternative to conventional statistical modelling methods to identify the non-linear relationship without complex equations.
Agatonovic-Kustrin
S
S
School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand. nena.kustrin@stonebow.otago.ac.nz
Wu
V
V
Rades
T
T
Saville
D
D
Tucker
I G
IG
D000897:Anti-Ulcer Agents / Q000737:chemistry*; D008956:Models, Chemical; D016571:Neural Networks, Computer; D011208:Powders / Q000737:chemistry; D011899:Ranitidine / Q000737:chemistry*; D012044:Regression Analysis; D014961:X-Ray Diffraction / Q000379:methods*
D000897:Anti-Ulcer Agents; D011208:Powders; D011899:Ranitidine