title: The effect of malnutrition on the metabolic response to surgery.
abstract: The effect of previous malnutrition on the metabolic response to surgical hysterectomy was investigated in adult female rats. Malnutrition was achieved by feeding a 20 g protein/kg diet and restricting food intake to 50% of normal. This dietary regimen was maintained for 3 weeks before surgery and for 4 d after surgery. Unoperated control rats were pair-fed with the hysterectomized rats after surgery. Energy balance was measured by the comparative carcass technique and, in a second experiment, urinary N excretion was measured. Surgery caused energy expenditure to increase by 37% in ad libitum-fed rats but in malnourished rats it increased by only 22%. Urinary N excretion rose immediately after surgery. In the ad libitum-fed rats it was on average 85% greater in hysterectomized rats than controls for the first 3 d after surgery, whereas in the restricted rats it was 74% greater on the first day and not significantly elevated thereafter. Thus, malnutrition attenuated the metabolic response to surgery but did not abolish it completely.
authors.affiliation: Department of Nutrition and Dietetics, King's College London, UK. peter.emery@kcl.ac.uk
authors.forename: P W
authors.initials: PW
authors.lastname: Emery
authors.forename: A R
authors.initials: AR
authors.lastname: Bosagh Zadeh
authors.forename: A
authors.initials: A
authors.lastname: Wasylyk
mesh_terms: D000818:Animals; D001823:Body Composition; D004734:Energy Metabolism; D005260:Female; D007044:Hysterectomy; D009584:Nitrogen / Q000652:urine; D009748:Nutrition Disorders / Q000378:metabolism*; D011184:Postoperative Period; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009584:Nitrogen