Phosphorus and proton magnetic resonance spectroscopy in episodic ataxia type 2.
Localized phosphorus (31P) and proton (1H) magnetic resonance spectroscopy was performed in the cerebellum and the occipital lobe of 6 patients with episodic ataxia type 2. From use of 31P magnetic resonance spectroscopy, untreated patients showed decreased high-energy phosphate ratios in the cerebrum, and increased pH in the cerebellum and cerebrum, which normalized under acetazolamide. 1H magnetic resonance spectra demonstrated high lactate peaks in 3 of the 6 patients. These metabolic alterations, probably induced by the calcium channelopathy, may characterize episodic ataxia type 2.
Sappey-Marinier
D
D
Unité RMN, Centre Hospitalier Lyon-Sud, France.
Vighetto
A
A
Peyron
R
R
Broussolle
E
E
Bonmartin
A
A
D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D001259:Ataxia / Q000188:drug therapy / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010758:Phosphorus; D011522:Protons
D011522:Protons; D010758:Phosphorus; D000086:Acetazolamide