[Severe hyponatremia during treatment with fluoxetine].
Serotonin reuptake inhibitors, used as antidepressants, may cause hyponatremia due to a syndrome of inappropriate antidiuretic hormone, specially in elders. Thirty cases with such complication have been reported in the last six years. We report a 76 years old female with a hypertensive cardiopathy and paroxysmal atrial fibrillation treated with amlodipine and sotalol. Five days after starting fluoxetine, the patient presented with a confusional state, gait instability and tremor. Laboratory assessment disclosed a plasma sodium of 115 meq/L. Fluoxetine was discontinued and fluids were restricted. The clinical condition of the patient improved and hyponatremia abated. Hyponatremia must be born in mind as a potential side effect of serotonin reuptake inhibitors.
Miranda
M
M
Unidad de Neurología, Hospital Félix Bulnes, Chile.
Armijo
G
G
Miranda
P
P
D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced*
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine
Hiponatremia severa durante terapia con fluoxetina en un caso.