title: [Hyperthyroxinemia and clinical euthyroidism. Report of one case].
abstract: The association of hyperthyroxinemia and euthyroidism is frequent and characterized by high plasma thyroxin concentrations, normal TSH values and absence of clinical signs of hyperthyroidism. We report an asymptomatic 28 years old male presenting with a serum total plasma thyroxin of 18.5 micrograms/dl (N 6.1-12.5), a free thyroxin of 2.9 ng/dl (N 0.8-1.4), a TSH of 3.4 microIU/ml (N 0.5-5), and a triiodothyronine of 128 ng/dl (N 80-180). Laboratory assessment did not find high thyroxin binding globulin, albumin or prealbumin concentrations or antithyroxin antibodies. The thyroxin binding capacity of albumin was elevated to 58.2 micrograms/dl (N 11.5-34.1). TSH responded normally to TRH stimulus and was suppressed with exogenous triiodothyronine, which caused an hyperthyroid syndrome. We concluded that this patient had a familial dysalbuminemia.
authors.affiliation: Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago.
authors.forename: J M
authors.initials: JM
authors.lastname: López
authors.forename: L
authors.initials: L
authors.lastname: Mosso
authors.forename: C
authors.initials: C
authors.lastname: Campino
mesh_terms: D000328:Adult; D005067:Euthyroid Sick Syndromes / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D006981:Hyperthyroxinemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008297:Male; D012709:Serum Albumin / Q000032:analysis; D013972:Thyrotropin / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014284:Triiodothyronine / Q000097:blood
chemical_list: D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013972:Thyrotropin
vernacular_title: Hipertiroxinemia con eutiroidismo clínico: análisis a propósito de un caso.