[Effect of antihypertensive agents on plasma endothelin, nitric oxide and so on in essential hypertension].
Ninty patients with mild to moderate essential hypertension (EH) were randomly divided into three groups and treated with Enalapril (E), Metoprolol (M) and Nifedipine (N) respectively. After a six-week-treatment, SBP and DBP of each of the three groups decreased significantly (vs. pre-treatment, P < 0.001). Plasma concentration of ET, NO, cGAMP and MDA in group M remained unchanged, and that of MDA in group N, especially of the stage II EH, decreased remarkably (vs. pretreatment, P < 0.05; vs. that of stage I EH, P < 0.05). While that of ET, NO, cGMP, and MDA in group E changed significantly (vs. Pretreatment, P < 0.01) and that of ET and MDA of stage II EH in group E exhibited more remarkable changes (vs. that of stage I, P < 0.05). It is suggested that E, and at some degree N, may protect the vascular endothelium from being damaged in EH, and also may contribute to prevent EH from development.
Chen
S
S
Department of Cardiology, General Hospital of PLA, Beijing.
Liu
G
G
Yang
T
T
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006152:Cyclic GMP / Q000097:blood; D004656:Enalapril / Q000627:therapeutic use; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D009569:Nitric Oxide / Q000097:blood*
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D016232:Endothelins; D009569:Nitric Oxide; D004656:Enalapril; D008790:Metoprolol; D006152:Cyclic GMP; D009543:Nifedipine