Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients.
Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0. 2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curve(infection)/area under the concentration-time curve(unaffected tissue) = 0.99 +/- 0.15 [mean +/- standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.
Müller
M
M
Departments of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria. markus.mueller@univie.ac.at
Brunner
M
M
Hollenstein
U
U
Joukhadar
C
C
Schmid
R
R
Minar
E
E
Ehringer
H
H
Eichler
H G
HG
D000368:Aged; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D017719:Diabetic Foot / Q000097:blood / Q000378:metabolism* / Q000382:microbiology; D005110:Extracellular Space / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D017551:Microdialysis
D000890:Anti-Infective Agents; D002939:Ciprofloxacin