title: Autologous and heterologous blood transfusion in head and neck cancer surgery.
abstract: OBJECTIVE
  To determine if the use of autologous blood ameliorates the increased risk for cancer recurrence that has been associated with perioperative blood transfusion.
  
  
  METHODS
  Retrospective medical record review.
  
  
  METHODS
  Tertiary care hospital.
  
  
  METHODS
  One hundred sixty-five consecutive patients with stages II to IV squamous cell carcinoma of the head and neck treated surgically at a university hospital from January 1, 1989, through December 31, 1994.
  
  
  METHODS
  We evaluated the impact of perioperative autologous and heterologous blood transfusion and 10 other variables on recurrence. Univariate and multivariate analyses were used.
  
  
  RESULTS
  Heterologous blood recipients had a 59% recurrence rate, whereas those who had received autologous blood or no transfusion had recurrence rates of 33% and 35%, respectively. The following 4 variables had a statistically significant association with recurrence by multivariate analysis: previous treatment of current malignancy (P<.001); receipt of heterologous blood (P = .04); positive margin (P = .04); and nodal disease (P = .04). The receipt of heterologous blood was associated with a 40% increased risk for recurrence.
  
  
  CONCLUSIONS
  Autologous blood products should be used during head and neck cancer surgery if possible when transfusion is necessary.
authors.affiliation: Department of Surgery, Stanford University Medical Center, Calif 94305-5328, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Moir
authors.forename: R N
authors.initials: RN
authors.lastname: Samy
authors.forename: M M
authors.initials: MM
authors.lastname: Hanasono
authors.forename: D J
authors.initials: DJ
authors.lastname: Terris
mesh_terms: D001804:Blood Transfusion, Autologous; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D014183:Transplantation, Heterologous