[Plasma homocysteine concentration in healthy middle-aged men and its presumed association with cardiovascular mortality].
It has recently become clear that hyperhomocysteinemia is an independent risk factor for vascular diseases. The plasma homocysteine concentrations of 71 healthy men (aged 40-49) living in Hungary were compared with those of randomly selected healthy age-matched men (n = 260) living in 11 different countries. The association between the mean plasma homocysteine concentration and reported cardiovascular mortality was analyzed in the respective countries. In Hungary the mean (+/- SD) plasma homocysteine concentration was 10.6 +/- 4.3 mumol/l. In the 11 other countries the mean (+/- SD) plasma homocysteine concentration ranged from 7.1 +/- 1.4 mumol/l (Schleiz, Germany, n = 20) to 10.7 +/- 2.1 mumol/l (Kuopio, Finland, n = 20). There was a significant correlation (r = 0.71, p < 0.005) between the plasma homocysteine concentration and male cardiovascular mortality in there countries. The strength of the correlation between the male plasma homocysteine concentration and cardiovascular mortality suggests that homocysteine may be an important factor in the variation of cardiovascular mortality between populations. The mean plasma homocysteine concentrations were the highest in the Hungarian (Budapest and Pest county) and the Finnish (Kuopio) groups but cardiovascular mortality is higher in Hungary than in Finland, referring to the pivotal role of other cardiovascular risk factors for the Hungarian population.
Bogye
G
G
Szubintenzív Belgyógyászati Osztály, Országos Reumatológiai és Fizioterápiás Intézet, Budapest.
Alfthan
G
G
Aro
A
A
Tátrai
T
T
D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality; D005387:Finland / Q000453:epidemiology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D006710:Homocysteine
Egészséges középkorú férfiak plazma homocystein koncentrációja és ennek feltételezett kapcsolata a szív- és érrendszeri halálozással.