title: Congenital asplenia detected in a 60 year old patient with septicemia.
abstract: A 60 year-old female who had never been seriously ill, was brought to the emergency ward after she had been found somnolent at home. She developed renal failure, meningitis, respiratory distress and disseminated intravascular coagulation. Overwhelming septicemia was evident, and streptococcus pneumoniae was isolated from blood and cerebrospinal fluid. Surprisingly, peripheral blood smears showed numerous Howell-Jolly-bodies, indicating severe impairment of splenic function. On abdominal ultrasound, CT-scan, and scintigraphy no spleen could be detected. There was no history of abdominal surgery. Apparently, congenital asplenia, which was not noticed until the age of 60, was responsible for the patient's life-threatening septicemia. We suggest that, in cases of severe septicemia, the examination of a blood smear is useful to detect functional (or congenital) asplenia.
authors.affiliation: Heinrich-Heine-University of Düsseldorf, Dept. of Hematology and Oncology, Moorenstr.5, D- 40225 Düsseldorf, Germany. Germing@haemonk.uni-duesseldorf.de
authors.forename: U
authors.initials: U
authors.lastname: Germing
authors.forename: C
authors.initials: C
authors.lastname: Perings
authors.forename: S
authors.initials: S
authors.lastname: Steiner
authors.forename: A J
authors.initials: AJ
authors.lastname: Peters
authors.forename: M P
authors.initials: MP
authors.lastname: Heintzen
authors.forename: C
authors.initials: C
authors.lastname: Aul
mesh_terms: D016470:Bacteremia / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013154:Spleen / Q000002:abnormalities* / Q000000981:diagnostic imaging; D013296:Streptococcus pneumoniae / Q000302:isolation & purification; D014463:Ultrasonography