Impact of troponins on the evaluation and treatment of patients with acute coronary syndromes.
Cardiac troponins possess superior sensitivity and specificity for the detection of cardiac injury. They can be used successfully to replace measurements of MB isoenzyme of creatine kinase or lactate dehydrogenase for the retrospective diagnosis of myocardial infarction. Measurement of these proteins confers powerful prognostic information that can be used to triage patients. An increasing body of data suggests that measurement of troponin proteins can be useful to guide therapeutic decisions in patients with acute coronary artery syndromes, especially regarding treatment with low-molecular-weight heparin or IIB/IIIA inhibitors. The absence of troponins in the circulation does not necessarily indicate the absence of coronary artery disease. With current assays, a significant diagnostic difference does not appear to exist between cardiac troponin I and T in patients with acute coronary artery syndromes.
Adams
J
J
Jewish Heart and Lung Institute, Jewish Hospital, Louisville, KY 40202, USA. jadams03@sprynet.com
D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D014218:Triage / Q000379:methods; D014336:Troponin / Q000097:blood*
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D014336:Troponin