title: Triple-technique (MR imaging, single-photon emission CT, and CT) coregistration for image-guided surgical evaluation of patients with intractable epilepsy.
abstract: Ictal and interictal single-photon emission CT (SPECT) play an increasingly important role in the surgical evaluation of patients with epilepsy. We present a method of coregistration of MR, SPECT, and CT images to correlate structural data (MR imaging), blood flow changes (SPECT), and location of subdural electrodes (CT) for patients undergoing image-guided surgical treatment of epilepsy. MR-SPECT root mean square (rms) mismatch distances were 2.1 to 2.5 mm, and MR-CT rms mismatch distances were 1.0 to 4.5 mm. Coregistration assisted in image-guided placement of subdural electrodes and in surgical resection of the suspected epileptogenic focus.
authors.affiliation: Department of Neurology, Saint Louis University, MO 63110, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Hogan
authors.forename: V J
authors.initials: VJ
authors.lastname: Lowe
authors.forename: R D
authors.initials: RD
authors.lastname: Bucholz
mesh_terms: D000293:Adolescent; D002560:Cerebrovascular Circulation / Q000502:physiology; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D013813:Therapy, Computer-Assisted; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed