title: Henoch-Schönlein purpura and pulmonary hemorrhage: a report and literature review.
abstract: Pulmonary hemorrhage, a rare complication of Henoch-Schönlein purpura (HSP) reported primarily in adults and adolescents, is associated with significant mortality. Although it has been suggested that pulmonary hemorrhage also occurs in children with HSP, the few cases reported lack a clear differentiation from pauci-immune vasculitis. We report a prepubertal child with HSP, pulmonary hemorrhage, and immunofluorescence-documented IgA deposits on renal biopsy. Aggressive supportive management and steroid therapy led to successful recovery. A review of the current literature is presented. Because other conditions clinically mimic HSP, appropriate serological studies and a kidney biopsy to confirm the diagnosis should be performed in severely affected patients with renal disease.
authors.affiliation: Department of Pediatrics, University of Minnesota, Minneapolis 55455-0392, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Vats
authors.forename: A
authors.initials: A
authors.lastname: Vats
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: D
authors.initials: D
authors.lastname: Dassenko
authors.forename: A R
authors.initials: AR
authors.lastname: Sinaiko
mesh_terms: D002648:Child; D005455:Fluorescent Antibody Technique; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D007070:Immunoglobulin A / Q000378:metabolism; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000209:etiology*; D008297:Male
chemical_list: D007070:Immunoglobulin A