title: Synthesis and anti-HIV activity of some S-acyl-2-thioethyl (SATE) phosphoramidate derivatives of 3'-azido-2',3'-dideoxythymidine.
abstract: The synthesis and in vitro anti-HIV activity of tBuSATE phosphoramidate derivatives of AZT incorporating several methyl-esterified alpha-amino acids are reported. The biological evaluation strongly supports the hypothesis that such compounds exert their anti-HIV effects via intracellular delivery of the corresponding 5'-mononucleotide.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, France.
authors.forename: D
authors.initials: D
authors.lastname: Egron
authors.forename: C
authors.initials: C
authors.lastname: Périgaud
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: A M
authors.initials: AM
authors.lastname: Aubertin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009943:Organophosphorus Compounds / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D009943:Organophosphorus Compounds; D015215:Zidovudine