Synthesis of alkenyl acyclonucleosides derivatives of 5-halogenouracil as antiviral and antitumoral agents.
Alkenyl acyclonucleosides derivatives of 5-halogenouracil have been synthesized via Michael addition reaction. These compounds were treated by allylbromide, propargylbromide or ethylbromoacetate to give the corresponding N-1,N-3-disubstituted 5-halogenouracil.
Rochdi
A
A
Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Maroc.
Taourirte
M
M
Redwane
N
N
Lazrek
H B
HB
Barascut
J L
JL
Imbach
J L
JL
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014498:Uracil / Q000737:chemistry*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides; D014498:Uracil