title: Argon plasma coagulation therapy for hemorrhagic radiation proctosigmoiditis.
abstract: BACKGROUND
  Radiation-induced proctosigmoiditis is a serious complication of pelvic radiation therapy. Rectal bleeding occurs among 6% to 8% of these patients and is extremely difficult to manage. Pharmacotherapy is generally ineffective, whereas surgical treatment is associated with high morbidity and mortality. Argon plasma coagulation is a new method of noncontact electrocoagulation well suited for hemostasis of large bleeding areas.
  
  
  METHODS
  From December 1996 through March 1998, we used argon plasma coagulation to treat 28 patients with hemorrhagic radiation-induced proctosigmoiditis. Indications for treatment were anemia (n = 18) and persistent bleeding despite pharmacotherapy (n = 10). Argon flow and electrical power were set at 1.5 L/min and 50 W. The severity of rectal bleeding was graded from 0 to 4 (highest), and hemoglobin levels were recorded before and after treatment.
  
  
  RESULTS
  Eighty-two therapeutic sessions were performed (median 2.9 sessions per patient). The severity score for rectal bleeding dropped at least 1 point for all but 2 patients, and the mean value decreased from 2.96 to 0.68. Average hemoglobin level increased 1.2 gm/dL (1.9 gm/dL among anemic patients). No serious complications were observed.
  
  
  CONCLUSIONS
  Argon plasma coagulation appears to be a simple, safe, and effective technique in the management of hemorrhagic radiation-induced proctosigmoiditis.
authors.affiliation: Department of Gastroenterology, Instituto Português de Oncologia, Porto, Portugal.
authors.forename: R A
authors.initials: RA
authors.lastname: Silva
authors.forename: A J
authors.initials: AJ
authors.lastname: Correia
authors.forename: L M
authors.initials: LM
authors.lastname: Dias
authors.forename: H L
authors.initials: HL
authors.lastname: Viana
authors.forename: R L
authors.initials: RL
authors.lastname: Viana
mesh_terms: D000328:Adult; D000368:Aged; D001128:Argon; D004564:Electrocoagulation / Q000295:instrumentation*; D019723:Endoscopes; D004867:Equipment Design; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000601:surgery*; D006489:Hemostatic Techniques / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000532:radiotherapy; D010865:Pilot Projects; D011350:Proctocolitis / Q000473:pathology / Q000601:surgery*; D011832:Radiation Injuries / Q000473:pathology / Q000601:surgery*; D012810:Sigmoid Diseases / Q000473:pathology / Q000601:surgery*; D020694:Sigmoidoscopes; D016896:Treatment Outcome
chemical_list: D001128:Argon