title: [Osteoporosis in multiple myeloma].
abstract: The problem of osteoporosis is world-wide in people above 50 years of age. As this period is also a risk period for the development of multiple myeloma or other malignant processes, comprehensive differential diagnosis of malignant and benign osteoporosis is essential. By retrospective analysis of a 12-year group of 270 patients treated by chemotherapy on account of multiple myeloma the authors selected a group of 151 patients treated in addition to chemotherapy and immunomodulating drugs (mixture of proteolytic enzymes-Wobe Mugos) for 2-3 years, also with biphosphonates. At the time ofdiagnosis osteoporosis was in 24.5% patients the only finding on bones. When biphosphonates (Bonefos, Ibandronate) and chemotherapy were administered during a three-year observation period the bone process was stable in 61.59%, osseous changes disappeared in 11.26% and progression of osteolysis was recorded in 27.15%. The objective of the work was to emphasize the importance of a correct diagnosis of osseous changes which can progress even in clinically asymptomatic myelomas.
authors.affiliation: Klinika hematológie a transfuziológie FN, Bratislava.
authors.forename: A
authors.initials: A
authors.lastname: Sakalová
authors.forename: Z
authors.initials: Z
authors.lastname: Herrmann
authors.forename: S
authors.initials: S
authors.lastname: Gazová
authors.forename: I
authors.initials: I
authors.lastname: Chabronová
authors.forename: L
authors.initials: L
authors.lastname: Dedík
authors.forename: M
authors.initials: M
authors.lastname: Mistrík
authors.forename: M
authors.initials: M
authors.lastname: Hrubisko
mesh_terms: D003937:Diagnosis, Differential; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies
chemical_list: D004164:Diphosphonates
vernacular_title: Problém osteoporózy pri mnohopocetnom myelóme.