A review of the effects of microgravity and of hypergravity on aging and longevity.
This article reviews the literature dealing with the effects of acute or chronic exposure to microgravity (spacecrafts) or hypergravity (centrifuge) on longevity and the aging process. Even if space flights are now common, the effects of these two kinds of environment on aging are still poorly documented, particularly in mammals. However, there is a growing interest for the use of the fruit fly Drosophila melanogaster, and this species may be now considered as a model organism in gravitational biology studies dealing with aging.
Le Bourg
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Unité Mixte de Recherche du Centre National de la Recherche Scientifique no 5550, Université Paul-Sabatier, Toulouse, France. lebourg@cict.fr
D000375:Aging / Q000502:physiology*; D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D006801:Humans; D018471:Hypergravity / Q000009:adverse effects*; D008136:Longevity / Q000502:physiology*; D008297:Male; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation