Flavone and xanthone derivatives related to fluoroquinolones.
A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have been tested for possible cytotoxic and antimicrobial activities. Cytotoxicity of both groups of compounds is rather poor, while the antibacterial activity is restricted to xanthones.
Mari
S
S
Institute of Pharmaceutical Chemistry, University of Milan, Italy.
Rossi
M
M
Valenti
P
P
Da Re
P
P
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D014970:Xanthines / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D024841:Fluoroquinolones; D014970:Xanthines