Disseminated intravascular coagulation in aortic aneurysms: assessment of consumption site using labeled-platelet scintigraphy.
BACKGROUND
It is known that disseminated intravascular coagulation (DIC) may occur along with aortic aneurysms. To assess the localization of the active consumption site we performed 111In-oxine labeled platelet scintigraphy in patients with chronic aortic aneurysms.


METHODS
Images were obtained using 111In-oxine labeled autologous platelets in 45 patients. Planar images were taken twice (at 4 and 48 hrs) after injection. A visual inspection of the radioactivity uptake and special analysis in regions of interest were performed.


RESULTS
Thirty-five patients (78%) showed a focal accumulation of radioactivity in the aortic aneurysm. Six of 13 patients (46%) with dissecting aortic aneurysm, and 4 of 32 patients (12.5%) with true aneurysms were evaluated as negative uptake by scintigram (p < 0.05). The aneurysm/heart ratio was 0.85 +/- 0.16 (mean +/- SD) (4 hrs) and 1.09 +/- 0.15 (48 hrs) after injection; the aneurysm/liver ratio was 0.56 +/- 0.16 (4 hrs) and 0.38 +/- 0.09 (48 hrs); the aneurysm/spleen ratio was 0.39 +/- 0.07 (4 hrs) and 0.39 +/- 0.08 (48 hrs).


CONCLUSIONS
When the probability of DIC is clinically high in patients with aortic aneurysms, 111In-oxine labeled platelet scintigraphy provides useful preoperative information regarding the location of the functionally active consumption focus.
Sakakibara
Y
Y
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Takeda
T
T
Hori
M
M
Mitsui
T
T
Ijima
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000000981:diagnostic imaging* / Q000601:surgery; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000601:surgery; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging* / Q000601:surgery; D001792:Blood Platelets; D004211:Disseminated Intravascular Coagulation / Q000000981:diagnostic imaging* / Q000601:surgery; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline