The in vitro effects of new non-steroidal antiinflammatory compounds on antioxidant system of human erythrocytes.
It has been reported by our group that some benzoxazolone and benzothiazolone derivatives showed significant antinociceptive and anti-inflammatory activity [DOGRUER et al. 1997]. It has been speculated that nonsteroidal anti-inflammatory drugs (NSAIDs) can act as the free radical scavengers and possess antioxidant activity. It is also well documented that oxidative stress can play an important role in the side effects of many xenobiotics including NSAIDs. Therefore, in the present study, the effects of six of the above mentioned benzoxazolone and benzothiazolone derivatives bearing 2-pyridylaminocarbonylmetyl moiety at the position 3 (I) on the antioxidant system-related parameters of human erythrocytes have been investigated. Diclofenac and nimesulid were also tested in the same systems as the control, because they are commonly used as NSAIDs. Our results showed that these compounds made significant changes in the antioxidant system of human erythrocyte.
Orhan
H
H
Department of Pharmaceutical Toxicology, Hacettepe University, Ankara, Turkey.
Doğruer
D S
DS
Cakir
B
B
Sahin
G
G
Sahin
M F
MF
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001583:Benzoxazoles / Q000494:pharmacology; D002374:Catalase / Q000097:blood; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004008:Diclofenac / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D016166:Free Radical Scavengers; D005979:Glutathione Peroxidase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D013449:Sulfonamides / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001583:Benzoxazoles; D016861:Cyclooxygenase Inhibitors; D016166:Free Radical Scavengers; D013449:Sulfonamides; D004008:Diclofenac; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; C012655:nimesulide