Studies of the relationship between ultrastructural synaptic plasticity and ribosome number in dendritic terminals in the rat neocortex in a cellular conditioning model.
The relationship between structural changes in postsynaptic densities of axodendritic synapses and the sizes of postsynaptic ribosomal aggregations were studied. A positive correlation was found between the thickness of the postsynaptic density and the number of ribosomes. The role of dendritic mRNA and the possible mechanisms supporting rapid local protein synthesis during the modification of postsynaptic components is seen on combined administration of two neuromediators into the rat neocortex.
Khludova
G G
GG
Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University.
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure; D003213:Conditioning, Psychological / Q000502:physiology*; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008959:Models, Neurological; D019579:Neocortex / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D012270:Ribosomes / Q000502:physiology* / Q000648:ultrastructure; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure