nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis.
From a library of DNA fragments associated with Ultrabithorax protein in vivo, we have isolated nessy, a new Drosophila gene that encodes a putative transmembrane protein conserved in evolution from Caenorhabditis elegans, to human. Zygotic expression occurs transiently in mesectodermal cells at gastrulation, proceeds in mesoderm and endoderm lineages during germ band movements and becomes then restricted to anterior and posterior domains in the visceral mesoderm. The Hox proteins Ultrabithorax, Antennapedia and AbdominalA are likely acting simultaneously to repress nessy in the other parts of the visceral mesoderm.
Maurel-Zaffran
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Laboratoire de Génétique et Physiologie du Développement, Institut de Biologie du Développement de Marseille, CNRS, Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288, Marseille Cedex 9, France.
Chauvet
S
S
Jullien
N
N
Miassod
R
R
Pradel
J
J
Aragnol
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian; D019143:Evolution, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D008565:Membrane Proteins; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; C121964:nes protein, Drosophila