title: Subsequential telomerase activity in exfoliated urinary cells detects recurrent disease in bladder cancer after transurethral resection.
abstract: We assessed urinary telomerase activity in bladder cancer patients to provide additional information for monitoring after transurethral resection (TUR). Urinary telomerase activity was detected in 22/26 (84.6%) patients with known bladder tumor before TUR. Ten of 11 patients who were available for sequential follow-up examination had urinary telomerase activity before TUR. In 4 of the 10 patients, urinary telomerase activity disappeared following TUR with or without adjuvant intravesical therapy. Three of the remaining 6 patients had recurrent bladder tumors within three months after TUR. Urinary telomerase activity analysis from patients after TUR provides important information on microscopic recurrent bladder cancer.
authors.affiliation: Department of Urology, Tokyo Medical University, Tokyo 160-0023, Japan.
authors.forename: S I
authors.initials: SI
authors.lastname: Kitsukawa
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: N
authors.initials: N
authors.lastname: Yahata
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Miki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D019098:Telomerase / Q000378:metabolism*; D014521:Urethra; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*
chemical_list: D019098:Telomerase