title: Identification of a novel penicillin-binding protein from Helicobacter pylori.
abstract: The Helicobacter pylori genome encodes four penicillin-binding proteins (PBPs). PBPs 1, 2, and 3 exhibit similarities to known PBPs. The sequence of PBP 4 is unique in that it displays a novel combination of two highly conserved PBP motifs and an absence of a third motif. Expression of PBP 4, but not PBP 1, 2, or 3, is significantly increased during mid- to late-log-phase growth.
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
authors.forename: P
authors.initials: P
authors.lastname: Krishnamurthy
authors.forename: M H
authors.initials: MH
authors.lastname: Parlow
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: S
authors.initials: S
authors.lastname: Burroughs
authors.forename: C
authors.initials: C
authors.lastname: Wickland
authors.forename: N B
authors.initials: NB
authors.lastname: Vakil
authors.forename: B E
authors.initials: BE
authors.lastname: Dunn
authors.forename: S H
authors.initials: SH
authors.lastname: Phadnis
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics* / Q000302:isolation & purification; D016680:Genome, Bacterial; D016480:Helicobacter pylori / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006602:Hexosyltransferases; D007536:Isomerism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D002267:Muramoylpentapeptide Carboxypeptidase / Q000737:chemistry* / Q000235:genetics* / Q000302:isolation & purification; D046915:Penicillin-Binding Proteins; D010406:Penicillins / Q000378:metabolism* / Q000494:pharmacology; D010458:Peptidyl Transferases; D011485:Protein Binding / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010406:Penicillins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase