Variants of endothelin-1 and its receptors in atopic asthma.
Endothelin-1 (ET-1) is a 21 amino acid peptide released from several types of bronchial cells. It operates through two types of receptors, type A(ET-RA) and type B(ET-RB) and has various activities in the pathophysiology of atopic asthma. These genes are localised on different chromosomes where genome-wide searches have identified linkage for atopic asthma, thus supporting the candidacy of ET-1 and its receptors for atopic asthma. A genetic association study was performed with variants of these three genes in both British (n = 300) and Japanese populations (n = 200). No significant association was found between variants of EDN1 and EDNRB genes, and atopic asthma in either population. However, variants of EDNRA gene showed a marginal association with atopy [odds = 0.39(95% CI: 0.17-0.89), p = 0.022, Pc = 0.066], especially with antigen specific IgE levels [odds = 0.31 (95% CI: 0.20-0.77), p = 0.006, Pc = 0.018] in the British population. These findings suggest that EDNRA is a major candidate locus for atopy on chromosome 4.
Mao
X Q
XQ
Experimental Medicine Unit, University of Wales Swansea, Swansea, United Kingdom.
Gao
P S
PS
Roberts
M H
MH
Enomoto
T
T
Kawai
M
M
Sasaki
S
S
Shaldon
S R
SR
Coull
P
P
Dake
Y
Y
Adra
C N
CN
Hagihara
A
A
Shirakawa
T
T
Hopkin
J M
JM
D000918:Antibody Specificity; D001249:Asthma / Q000235:genetics* / Q000276:immunology; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D019332:Endothelin-1 / Q000235:genetics*; D004739:England; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007564:Japan; D016017:Odds Ratio; D010641:Phenotype; D011247:Pregnancy; D020033:Protein Isoforms / Q000235:genetics; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000235:genetics*
D019332:Endothelin-1; D020033:Protein Isoforms; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin; D007073:Immunoglobulin E