title: Extracorporeal resuscitation of cardiac arrest.
abstract: OBJECTIVE
  Extracorporeal support of heart and lung function (venoarterial perfusion) during cardiac arrest (ECPR) has been advocated as a means of improving survival following cardiac arrest. The authors retrospectively reviewed their institution's seven-year experience with this intervention.
  
  
  METHODS
  Emergency department patients and inpatients in cardiac arrest or immediately postarrest were considered candidates. ECPR was instituted using venoarterial bypass and was continued until patients regained sufficient cardiopulmonary function to allow weaning from the device or until their condition was deemed irrecoverable.
  
  
  RESULTS
  ECPR was attempted in 25 patients and successfully instituted in 21. Four patients (16%) were converted from ECPR to ventricular assist devices, two of whom survived and await transplantation. Seven additional patients were discharged from the hospital, resulting in an overall survival of 36%. Because none of the children treated survived, there was a trend toward higher age among survivors (survivors 40 +/- 14 yr, nonsurvivors 33 +/- 15 yr, p = 0.29). The duration of conventional CPR was shorter among survivors (survivors 21 +/- 16 min, nonsurvivors 43 +/- 32 min, p = 0.04), as was the duration of extracorporeal support (survivors 44 +/- 21 hr, nonsurvivors 87 +/- 96 hr, p = 0.18). Survival was seen only in patients whose conditions were amenable to a definitive therapeutic intervention, particularly cardiac arrest due to respiratory or pulmonary embolic disease. While four of the five patients treated in the ED were successfully supported, none survived to discharge.
  
  
  CONCLUSIONS
  In select patients with reversible disease, extracorporeal CPR can be used to successfully treat cardiac arrest. Further investigation into its most appropriate application is warranted.
authors.affiliation: Extracorporeal Life Support Service, University of Michigan, Ann Arbor, USA. jyounger@umich.edu
authors.forename: J G
authors.initials: JG
authors.lastname: Younger
authors.forename: R J
authors.initials: RJ
authors.lastname: Schreiner
authors.forename: F
authors.initials: F
authors.lastname: Swaniker
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
authors.forename: R A
authors.initials: RA
authors.lastname: Chapman
authors.forename: R H
authors.initials: RH
authors.lastname: Bartlett
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D002675:Child, Preschool; D004868:Equipment Failure / Q000706:statistics & numerical data; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation / Q000592:standards*; D005260:Female; D006323:Heart Arrest / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome