Chemical and enzymatic synthesis and antiviral properties of 2'-deoxy-2'-fluoroguanosine.
Chemical and enzymatic methods were employed for the synthesis of the title compound, 2'F-Guo 7. High antiviral activity of 2'F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).
Zaitseva
G V
GV
Institute of Bioorganic Chemistry, National Academy of Sciences, Belarus.
Zinchenko
A I
AI
Barai
V N
VN
Pavlova
N I
NI
Boreko
E I
EI
Mikhailopulo
I A
IA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002642:Chick Embryo; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects
D000998:Antiviral Agents; C083670:2'-deoxy-2'-fluoroguanosine; D003849:Deoxyguanosine