The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections.
Helminth infections induce the production of type 2 cytokines, which contribute both to expulsion of the worms and inflammatory responses that can either protect or damage the host. Although IL-4 has been considered the most critical cytokine for both inflammation and protective immunity, recent observations indicate that IL-13 - a related cytokine - can have equal or even greater importance than IL-4 in inflammatory responses and host protection against infection.
Finkelman
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FD
Division of Immunology, University of Cincinnati College of Medicine, PO Box 670563, OH 45267-0563, USA. ffinkelman@mem.po.com
Wynn
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TA
Donaldson
D D
DD
Urban
J F
JF
D000818:Animals; D004064:Digestive System / Q000469:parasitology; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D018793:Interleukin-13 / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology; D009349:Nematode Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D018793:Interleukin-13; D015847:Interleukin-4