Deletion polymorphism in the gene for angiotensin-converting enzyme is not a risk factor predisposing to abdominal aortic aneurysm.
OBJECTIVE
to establish whether deletion of the angiotensin-converting enzyme (ACE) gene is a risk factor predisposing to abdominal aortic aneurysm (AAA) or not.


METHODS
the study included 125 patients with AAA and 153 controls randomly selected from 328 individuals. The control subjects were confirmed not to have an AAA, but matched with the AAA group for age, sex, hypertension, diabetes mellitus, and hyperlipidaemia. The presence of ACE polymorphism was detected by a polymerase chain reaction using DNA extracted from blood.


RESULTS
the distribution of ACE genotypes and allele frequencies in the control and AAA groups was not significantly different.


CONCLUSIONS
the deletion polymorphism in the ACE gene is not a risk factor for AAA.
Hamano
K
K
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Ohishi
M
M
Ueda
M
M
Fujioka
K
K
Katoh
T
T
Zempo
N
N
Fujimura
Y
Y
Okamura
A
A
Rakugi
H
H
Higaki
J
J
Ogihara
T
T
Esato
K
K
D000368:Aged; D000483:Alleles; D000704:Analysis of Variance; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D007703:Peptidyl-Dipeptidase A