Endometrial stromal sarcoma with clonal complex chromosome abnormalities. Report of a case and review of the literature.
Only eleven endometrial stromal sarcomas (ESS) with clonal chromosomal abnormalities have been reported in the literature. Of these, four have been reported to harbor the t(7;17) translocation. We report here an additional ESS that exhibited clonal complex chromosome abnormalities not described earlier: 38,XX,-1,del(1)(q11),-2,add(2)(p13),-3,der(4)add(4)(p12)psu dic(4;14)(q35;q11.2), add(6)(p21.3),add(7)(q22),del(7)(p11.2p13),-8,-9,add(9)(q34),- 10,add(10)(q24),-11,-11,ins(12;?) (q13;?),-14,-14,-15,ins(15;?)(q22;?),add(16)(q22),add(17)(q11.2),- 18,der(18)t(7;18)(q11.2;p11.2),-19, add(20)(p13),add(21)(p11.2),-22,add(22)(p11.2),+6mar in metaphase cells from primary short-term culture.
Sonobe
H
H
Department of Pathology, Kochi Medical School, Japan.
Iwata
J
J
Furihata
M
M
Ohtsuki
Y
Y
Taguchi
T
T
Shimizu
K
K
D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D018203:Sarcoma, Endometrial Stromal / Q000235:genetics* / Q000473:pathology