[The effect of minimal dexamethasone on the rate of growth of mouse embryonic fibroblasts in vitro].
OBJECTIVE
To study of the relationship between inhibition of the growth rate of mouse embryonic fibroblasts (MEF) and the dosage of dexamethasone.


METHODS
Cell culture.


RESULTS
The effect was observed from 48 to 72 hours after addition of 50 micrograms/ml (0.005%) dexamethasone. In comparison with the control, the number of MEF was cut down by 16%-26%, whereas the addition of dexamethasone between 1 microgram/ml and 10 micrograms/ml (0.0001-0.001%) had no significant effect on the rate of growth of MEF.


CONCLUSIONS
The minimal dosage of dexamethasone has no significant inhibitory effect on the growth rate of fibroblasts and wound healing.
Zhu
Z
Z
Department of Ophthalmology, Zhongshan Hospital, Shanghai Medical University.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D014709:Vero Cells / Q000187:drug effects
D005938:Glucocorticoids; D003907:Dexamethasone