title: Graves' disease and thyroid associated ophthalmopathy triggered by 131I treatment of non-toxic goiter.
abstract: A 39-year-old Danish woman was treated with an oral dose of 400 MBq 131I for a non-toxic goiter with compression symptoms. Serum anti-TPO and TSH receptor antibodies were negative before radioiodine therapy. The patient developed hyperthyroidism four months after treatment and ophthalmopathy after another three months. TSH receptor stimulating and blocking antibodies, eye muscle IgA and IgG were measured and an increase in stimulating TSH receptor antibodies were found concomitant with development of hyperthyroidism. IgG class antibodies against porcine eye muscle antigens and eye muscle fibroblasts were elevated and unchanged during the follow-up. A significant increase in IgA class antibodies against porcine eye muscle antigens was seen concomitant with development of ophthalmopathy. It is speculated that 131I has led to an exacerbation of eye muscle as well as TSH receptor stimulating antibodies and possibly leading to the development of ophthalmopathy, or at least is associated with it.
authors.affiliation: Department of Endocrinology F, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Nygaard
authors.forename: R A
authors.initials: RA
authors.lastname: Metcalfe
authors.forename: J
authors.initials: J
authors.lastname: Phipps
authors.forename: A P
authors.initials: AP
authors.lastname: Weetman
authors.forename: L
authors.initials: L
authors.lastname: Hegedüs
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000209:etiology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D018828:Immunoglobulins, Thyroid-Stimulating / Q000032:analysis; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013974:Thyroxine