title: Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children.
abstract: Insulin-like growth factor I (IGF-I) is a major regulator of bone growth during childhood. However, beyond knowledge that IGF-I influences longitudinal growth, its associations to changes in the cross-sectional dimensions, the volume, or the material density of bone during growth are unknown. We assessed the relationships between serum IGF-I and measurements of cross-sectional area, cortical bone area, and cortical bone density at the midshaft of the femur in 197 normal healthy white children and adolescents (103 boys and 94 girls; aged 7.8-18.2 yr). Bone determinations were obtained using computed tomography, and levels of IGF-I were measured by RIA after an extraction procedure. IGF-I correlated significantly with both cross-sectional area (r = 0.49; P < 0.0001) and cortical bone area (r = 0.50; P < 0.0001), but did not correlate with the material density of cortical bone (r = -0.08). Multiple regression analyses showed that circulating levels of IGF-I were associated with cross-sectional area (P = 0.03) and cortical bone area (P = 0.04) values, even after correcting for the confounding effects of age, gender, weight, and femoral length. We conclude that IGF-I is a major determinant of the cross-sectional properties of bone, but does not influence the material density of bone, in the appendicular skeleton.
authors.affiliation: Department of Radiology, Children's Hospital, Los Angeles, California 90027, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mora
authors.forename: P
authors.initials: P
authors.lastname: Pitukcheewanont
authors.forename: J C
authors.initials: JC
authors.lastname: Nelson
authors.forename: V
authors.initials: V
authors.lastname: Gilsanz
mesh_terms: D000293:Adolescent; D015519:Bone Density; D001842:Bone and Bones / Q000033:anatomy & histology*; D002648:Child; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D007334:Insulin-Like Growth Factor I