title: Toxicity of fatty acid 18:5n3 from Gymnodinium cf. mikimotoi: I. Morphological and biochemical aspects on Dicentrarchus labrax gills and intestine.
abstract: We present evidence for the toxic effects of fatty acid 18:5n3 (octadecapentaenoic acid) in the gills and intestine of the sea bass Dicentrarchus labrax. Light microscopic observation of gills showed strong mucus production and alteration of ionocytes. The Mg- and Na,K-ATPase activities were inhibited, with IC50 values of 10(-3) and 1.6 x 10(-4) M, respectively. Results are discussed in relation to osmoregulation.
authors.affiliation: LPTE, Université de Nice-Sophia Antipolis, France. sola@unice.fr
authors.forename: F
authors.initials: F
authors.lastname: Sola
authors.forename: A
authors.initials: A
authors.lastname: Masoni
authors.forename: B
authors.initials: B
authors.lastname: Fossat
authors.forename: J
authors.initials: J
authors.lastname: Porthé-Nibelle
authors.forename: P
authors.initials: P
authors.lastname: Gentien
authors.forename: G
authors.initials: G
authors.lastname: Bodennec
mesh_terms: D000818:Animals; D001492:Bass / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors; D004141:Dinoflagellida / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000633:toxicity; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000633:toxicity*; D005880:Gills / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007422:Intestines / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase