Structure of the respiratory NADH:ubiquinone oxidoreductase (complex I)
Three-dimensional structures of NADH:ubiquinone oxidoreductase (or complex I) from the respiratory chain of mitochondria and bacteria have been recently studied by electron microscopy. The low-resolution structures all reveal a characteristic L shape for complex I; however, some of the differences among these structures may have important implications for the location of the functional elements of complex I, for example, the ubiquinone-binding site.
Grigorieff
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WM Keck Institute for Cellular Visualization, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, MA 02454-9110, USA. niko@brandeis.edu
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D001665:Binding Sites; D002417:Cattle; D007501:Iron / Q000737:chemistry; D008854:Microscopy, Electron; D008928:Mitochondria / Q000737:chemistry; D008958:Models, Molecular; D009243:NAD / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D011487:Protein Conformation; D013455:Sulfur / Q000737:chemistry
D001426:Bacterial Proteins; D009243:NAD; D013455:Sulfur; D007501:Iron; D016660:NAD(P)H Dehydrogenase (Quinone)