Two antimicrobial alkaloids from Bocconia arborea.
Two alkaloid constituents of Bocconia arborea showed considerable antimicrobial activity against gram-positive and gram-negative bacteria and Candida albicans. Bioactivity-guided fractionation with thin-layer bioautography led to the isolation of the two known benzophenanthridine alkaloids, dihydrochelerythrine and dihydrosanguinarine. The minimal inhibitory concentration was determined for each compound using a twofold serial dilution assay. The structures of these compounds were determined by 1H and 13C NMR analyses.
Navarro
V
V
Laboratorio de Microbiologia, Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Mor., México.
Delgado
G
G
D000470:Alkaloids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008519:Medicine, Traditional; D008800:Mexico; D008826:Microbial Sensitivity Tests; D010207:Papaver / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D015003:Yeasts / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts