Inhibition of intra-tumoral angiogenesis and glioma growth by the fibroblast growth factor inhibitor 1,3,6-naphthalenetrisulfonate.
1,3,6-naphthalenetrisulfonate (NTS) can inhibit the proliferation in vitro of cells of various origin including glioma. We have studied the effects of NTS on intra-tumoral angiogenesis and tumor growth in the rabbit cornea after implantation of C6 rat glioma cells. It was found that neovascularization and glioma growth were abolished by topical administration of NTS. This effect could be mediated by both induction of programmed cell death and inhibition of growth, in endothelium and in tumor cells, most likely as a consequence of the disruption of the autocrine and paracrine effects of FGF released from endothelial and tumor cells. The results suggest that NTS is a promising candidate to lead the development of new angiogenesis inhibitors for the treatment of cancer and other diseases whose progression is dependent upon the development of new blood vessels.
Cuevas
P
P
Servicio di Histologia, Hospital Ramón y Cajal, Madrid, Spain.
Carceller
F
F
Reimers
D
D
Cuevas
B
B
Lozano
R M
RM
Giménez-Gallego
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001254:Astrocytoma / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply*; D003315:Cornea; D005260:Female; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors*; D009282:Naphthalenesulfonates / Q000494:pharmacology / Q000627:therapeutic use*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors*; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D011817:Rabbits; D051381:Rats; D014407:Tumor Cells, Cultured / Q000637:transplantation
C114532:1,3,6-naphthalenetrisulfonate; D000970:Antineoplastic Agents; D009282:Naphthalenesulfonates; D009363:Neoplasm Proteins; D005346:Fibroblast Growth Factors