Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition.
Marnett
L J
LJ
Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, the Vanderbilt Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. marnett@toxicology.mc.vanderbilt.edu
Rowlinson
S W
SW
Goodwin
D C
DC
Kalgutkar
A S
AS
Lanzo
C A
CA
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D002384:Catalysis; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins; D008958:Models, Molecular; D010100:Oxygen / Q000378:metabolism*; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D016718:Arachidonic Acid; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D010100:Oxygen