Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity.
A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.
Franchetti
P
P
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Abu Sheikha
G
G
Cappellacci
L
L
Grifantini
M
M
Balestra
E
E
Perno
C F
CF
Brandi
G
G
Rossi
L
L
Magnani
M
M
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000821:virology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
C120723:ACVpPMPA; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D009705:Nucleosides