title: Investigations on magnesium and chromium antagonism in the skin of experimental animals.
abstract: Investigations were performed over 30 days on 25 male rats Wistar breed divided into five groups. Animals received intraperitoneally (i.p.) potassium dichromate (KDCH) 5 mg/kg (basal doses, b.d.), 2 mg/kg (0.4 b.d.) and 100 mg Mg Cl2/kg body weight (b.w.). In performed investigations the highest concentration of chromium in animal skin 1.17 +/- 0.11 micrograms/g was observed by i.p. administration of KDCH 5 mg/kg b.w. Simultaneous i.p. administration of KDCH 5 mg/kg b.w. and MgCl2 100 mg/kg b.w. resulted in significant lower concentration of chromium (in comparison to the preceding group) in animal skin: 0.8 +/- 0.2 microgram/g (p < 0.001). In i.p. administration of KDCH in the doses of 0.4 b.d. the concentration of Cr in the skin amounted to 0.55 +/- 0.1 microgram/g. Values of Cr in the skin in exposed groups were significantly higher than in the control group, (p < 0.001).
authors.affiliation: Polyclinic of Gniezno Tannery, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Bulikowski
authors.forename: I
authors.initials: I
authors.lastname: Pietrzak
authors.forename: A
authors.initials: A
authors.lastname: Borzecki
authors.forename: W
authors.initials: W
authors.lastname: Lingas
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D002857:Chromium / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008274:Magnesium / Q000032:analysis / Q000378:metabolism*; D015636:Magnesium Chloride / Q000494:pharmacology*; D008297:Male; D011192:Potassium Dichromate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015636:Magnesium Chloride; D002857:Chromium; D008274:Magnesium; D002118:Calcium; D011192:Potassium Dichromate