Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma.
We examined the extent of lipid peroxidation and the status of reduced glutathione (GSH) and the GSH-dependent enzymes-glutathione peroxidase (GPx) and glutathione-S-transferase (GST)-in oral tumour tissues from 33 adult oral cancer patients and an equal number of age- and sex-matched normal subjects. Diminished lipid peroxidation in the oral tumour tissue was accompanied by a significant decrease in phospholipids and an increase in the cholesterol/phospholipid (C/P) ratio. The concentration of glutathione and the activities of GPx and GST were elevated in oral tumour tissues. These findings suggest that GSH- and GSH-dependent enzymes play a crucial role in tobacco-related tumourigenesis and may be considered as markers of carcinogen exposure.
Saroja
M
M
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.
Balasenthil
S
S
Nagini
S
S
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology
D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione