Genomic alterations in human meningiomas detected by restriction landmark genomic scanning and immunohistochemical studies.
Using restriction landmark genomic scanning (RLGS) methods, 21 samples of human meningioma were analyzed. We found 3 alterations in the genomic DNAs of tumor samples located on chromosomes 5, 14 and 17 which appear to be common to the meningothelial subtype. Two other separate genetic abnormalities located on chromosomes 9-12 and 20 are apparently associated with atypical meningiomas. In addition, the neurofibromatosis type 2 gene is apparently involved in more than half of the tumor samples. There appear to be both common and type-specific genetic mutations associated with the formation and progression of human meningiomas.
Inui
T
T
Second Department of Pathology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
Konishi
N
N
Nakamura
M
M
Cho
M
M
Naitou
H
H
Yamamoto
K
K
Tsuzuki
T
T
Kawai
S
S
Tsunoda
S
S
Sakaki
T
T
Hiasa
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015894:Genome, Human; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000235:genetics*; D008579:Meningioma / Q000737:chemistry / Q000235:genetics*; D008875:Middle Aged; D015183:Restriction Mapping / Q000379:methods*