A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines.
We have characterized a novel human gene (C14orf1) which codes for a polypeptide homologous to the yeast protein Yer044c. Both the human and yeast proteins are predicted to be highly basic and to present several potential, evolutionarily conserved, transmembrane domains. C14orf1 mRNA was found to be particularly abundant in the adult testis and in several cancer cell lines. The gene maps to chromosome band 14q24. Further investigations should be performed to understand the role of C14orf1 in the testis and the significance of its strong expression in the cell lines studied here.
Veitia
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RA
Unité d'Immunogénétique Humaine, Institut Pasteur, Paris, France. rveitia@pasteur.fr
Ottolenghi
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C
Bissery
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MC
Fellous
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D017124:Conserved Sequence; D015870:Gene Expression; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D016366:Open Reading Frames / Q000235:genetics; D016133:Polymerase Chain Reaction; D013737:Testis / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D015003:Yeasts / Q000235:genetics
C121701:ERG28 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins