No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese.
The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.
Hu
C J
CJ
Department of Neurology, China Medical College Hospital, Taiwan.
Sung
S M
SM
Liu
H C
HC
Lee
K Y
KY
Hsu
W C
WC
Wong
W K
WK
Lee
C C
CC
Tsai
C H
CH
Chang
J G
JG
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D013624:Taiwan; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins