Primary Sjögren's syndrome (pSS): subjective symptoms and salivary findings.
We studied the relationship between dry mouth, general health and objective findings in 16 patients having primary Sjögren's syndrome (pSS) according to the 1993 European classification criteria as well as in healthy controls. Serum autoantibody to SSA/SSB (AB) was correlated to unstimulated whole saliva flow (UWS) and labial salivary gland focus score (FS). All patients had dry mouth symptoms and UWS < or = 0.10 ml/min, but patients with UWS < 0.05 ml/min and AB had more complaints of oral and ocular dryness. These patients also tended to have more exocrine and non-exocrine manifestations, and oral dryness had a greater impact on their self-reported general health than in patients with UWS > or = 0.05 ml/min. Accordingly, we consider rating of oral dryness by visual analogue scales or categorised questionnaires to be valuable for the evaluation of oral involvement in pSS.
Pedersen
A M
AM
Department of Oral Function and Physiology, School of Dentistry, University of Copenhagen, Denmark.
Reibel
J
J
Nauntofte
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D001706:Biopsy; D005260:Female; D006304:Health Status; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood; D012463:Saliva / Q000378:metabolism*; D012470:Salivary Glands, Minor / Q000378:metabolism / Q000473:pathology; D012649:Self Concept; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D014985:Xerophthalmia / Q000175:diagnosis; D014987:Xerostomia / Q000175:diagnosis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007075:Immunoglobulin M; C035356:SS-A antibodies; C035357:SS-B antibodies; D012217:Rheumatoid Factor