[The formation of autoimmune complexes as an index of bioincompatibility in reconstructive heart operations].
The manifestation of bioincompatibility in the shape of complement-dependent changes: solubilisation and inhibition--of immune complexed formation was investigated in patients at the prosthetic cardiac operations with using artificial blood circulation, artificial cardiac valves and heterotopic vascular grafts. It was established, that the solubilisation of the precipitate, preformed by plasmic fibrinogen with antifibrinogenic immunoglobulin, and inhibition of hemagglutinating activity of normal autoantibodies in plasma appeared in several minutes after the contact of alien mains with own blood circulation system. These changes of formation of immune complexes in plasma, caused by complement activation, had a selective and reversible nature and were followed breaches of blood circulation. Estimation of early, functional indexes of bioincompatibility, displaying by changes of immune complex formation, may be helpful in prognostic relation in patients with immunocomplex diseases at prosthetic cardiac operations.
Shevchenko
V S
VS
Institute of Cardiovasculary Surgery, Academy of Medical Sciences of Ukraine, Kyïv.
D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001672:Biocompatible Materials / Q000009:adverse effects*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures; D003165:Complement System Proteins / Q000032:analysis; D003327:Coronary Disease / Q000276:immunology / Q000601:surgery; D004697:Endocarditis, Bacterial / Q000276:immunology / Q000601:surgery; D005112:Extracorporeal Circulation; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D007432:Intraoperative Period; D011184:Postoperative Period; D012995:Solubility; D013997:Time Factors
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001672:Biocompatible Materials; D003165:Complement System Proteins
Utvorennia autoimunnykh kompleksiv iak pokaznyk bionesumisnosti pry vidnovnykh operatsiiakh na sertsi.