Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-E] [1,3]diazepine-5'-triphosphate.
The title nucleoside, 4,8-diamino-6-imino-6H-1-beta-d-ribofuranosylimidazo[4,5-e][1,3]-d iazepine, exhibited potent anti-hepatitis B viral activity with minimum toxicity in vitro, and its 5'-triphosphate derivative strongly inhibited the bacteriophage T7 RNA polymerase.
Bretner
M
M
Department of Chemistry & Biochemistry, University of Maryland, Baltimore County 21250, USA.
Beckett
D
D
Hosmane
R S
RS
D000998:Antiviral Agents / Q000494:pharmacology*; D001483:Base Sequence; D004247:DNA; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects*; D009705:Nucleosides / Q000494:pharmacology*; D013698:Templates, Genetic; D014407:Tumor Cells, Cultured; D014764:Viral Proteins
C120720:4,8-diamino-6-imino-6H-1-ribofuranosylimidazo-4,5-e--1,3-diazepine-5'-triphosphate; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009705:Nucleosides; D014764:Viral Proteins; D004247:DNA; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases