Human-porcine receptor-ligand compatibility within the immune system: relevance for xenotransplantation.
Immune responses to xenografts are likely to be highly dependent on the efficiency of molecular interactions between the donor and the recipient species. This brief review summarizes what is currently known about the compatibilities across the human-porcine species barrier of the molecular interactions that are important in the immune response.
Warrens
A N
AN
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston 02129, USA.
Simon
A R
AR
Theodore
P R
PR
Sykes
M
M
D000818:Animals; D006650:Histocompatibility Testing; D006801:Humans; D008024:Ligands; D016377:Organ Transplantation; D011971:Receptors, Immunologic / Q000276:immunology*; D013045:Species Specificity; D013552:Swine; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous
D008024:Ligands; D011971:Receptors, Immunologic