The leukocyte immunoglobulin-like receptors (LIRs): a new family of immune regulators.
Identification of a counterstructure for the human cytomegalovirus-encoded major histocompatibility complex class I-related gene product, UL18, has led to the discovery of a novel family of immunoreceptors, termed leukocyte immunoglobulin-like receptors (LIRs). The LIRs are differentially expressed in cells of the dendritic cell, monocytic and lymphocytic lineages, and appear to mediate diverse roles in immune regulation. This review summarizes the expression, distribution, and signaling capacities of the LIRs and discusses possible roles of the LIRs in both inhibition and activation of the cellular responses.
Fanger
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Immunex Corporation, Seattle, Washington 98101, USA. nfanger@immunex.com
Borges
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Cosman
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D000818:Animals; D015703:Antigens, CD; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D009000:Monocytes / Q000276:immunology; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000276:immunology*; D015398:Signal Transduction
D015703:Antigens, CD; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D011971:Receptors, Immunologic