title: Mast cell degranulating (MCD) peptide: a prototypic peptide in allergy and inflammation.
abstract: The solid phase synthesis of mast degranulating peptide (MCD peptide) raised the possibility of preparing analogs and examining the pharmacology and the proposed role of this peptide as a potential agent in allergy and inflammation. MCD peptide, a cationic 22-amino acid residue peptide with two disulfide bridges, causes mast cell degranulation and histamine release at low concentrations and has anti-inflammatory activity at higher concentrations. Because of these unique immunologic properties, MCD peptide may serve as a useful tool for studying secretory mechanisms of inflammatory cells such as mast cells, basophils, and leukocytes, leading to the design of compounds with therapeutic potential.
authors.affiliation: Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: A
authors.initials: A
authors.lastname: Buku
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology*; D010455:Peptides / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010455:Peptides; C008331:mast cell degranulating peptide