title: Effects of continuous negative airway pressure on lung volume and respiratory resistance.
abstract: This study was designed to determine the responses of lung volume and respiratory resistance (Rrs) to decreasing levels of continuous negative airway pressure (CNAP). Twenty normal subjects were studied in the basal state and under CNAP levels of -5, -10, and -15 hPa. Rrs was measured by the forced oscillation technique (4-32 Hz). End-expiratory lung volume (EELV) and tidal volume (VT) were measured by whole body plethysmography. Rrs was extrapolated to 0 Hz (R(0)) and estimated at 16 Hz (R(16)) by linear regression analysis of Rrs vs. frequency. Specific Rrs, SR(0) and SR(16), were then calculated as R(0) (EELV + VT/2) and R(16) (EELV + VT/2), respectively. EELV significantly decreased, whereas R(0), R(16), SR(0), and SR(16) significantly increased, as the CNAP level decreased (P < 0.0001 for all). At the lowest CNAP level, R(0) and R(16) reached 198 +/- 13 and 175 +/- 9% of their respective basal values. The CNAP-induced increase in R(0) was significantly higher than that in R(16) (P < 0.004). Our results demonstrate that the CNAP-induced increase in Rrs does not result from a direct lung volume effect only and strongly suggest the involvement of other factors affecting both intrathoracic and extrathoracic airway caliber.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale and Service de Physiologie-Explorations Fonctionnelles, Hôpital Henri Mondor, AP-HP, 94010 Créteil, France. anne-marie.lorino@hmn.ap-hop-paris.fr
authors.forename: A M
authors.initials: AM
authors.lastname: Lorino
authors.forename: K
authors.initials: K
authors.lastname: Hamoudi
authors.forename: F
authors.initials: F
authors.lastname: Lofaso
authors.forename: E
authors.initials: E
authors.lastname: Dahan
authors.forename: C
authors.initials: C
authors.lastname: Mariette
authors.forename: A
authors.initials: A
authors.lastname: Harf
authors.forename: H
authors.initials: H
authors.lastname: Lorino
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000502:physiology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010991:Plethysmography; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology*; D012044:Regression Analysis; D012121:Respiration, Artificial; D013990:Tidal Volume / Q000502:physiology*