title: Relationship of physical activity and fitness to lipid and lipoprotein (a) in elderly subjects.
abstract: OBJECTIVE
  To determine, both by a cross-sectional and longitudinal study design, the relationship of maximal oxygen consumption (VO2max) and physical activity (PA) to blood lipids and lipoprotein(a) [Lp(a)] in a population of healthy and weight-stable elderly volunteers aged 66-84 yr.
  
  
  METHODS
  In a cross-sectional study in 52 subjects (23 men and 29 women), all independent variables (age, anthropometric, VO2max, and PA indices) were used in a multiple stepwise regression analysis to select variables influencing lipid and lipoprotein parameters. In a prospective nonintervention study, 38 subjects (17 men and 21 women) were reexamined after 6 months.
  
  
  RESULTS
  In a cross-sectional study, sports activity index contributed significantly to total cholesterol (TC), low density lipoprotein (LDL) cholesterol (LDL-C), TC/high density lipoprotein (HDL) cholesterol (HDL-C) ratio, and LDL-C/HDL-C ratio variance in men, whereas VO2max accounted for 23% variance of apolipoprotein A-I in women. In a prospective study, there was no indication that any measured variable was correlated with absolute or relative changes in PA indices in the total group or when analyzed by gender.
  
  
  CONCLUSIONS
  These data confirm that favorable relationship between PA/fitness and blood lipid profile is visible in elderly people but spontaneous changes in habitual PA are not a sufficient stimulus to alter serum lipid and lipoprotein levels in this population. Furthermore, there is no direct association between Lp(a) levels and PA, fitness, or body composition in the elderly men and women.
authors.affiliation: Service de Médecine Gériatrique, Centre Hospitalier Lyon-Sud, Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Kostka
authors.forename: J R
authors.initials: JR
authors.lastname: Lacour
authors.forename: S E
authors.initials: SE
authors.lastname: Berthouze
authors.forename: M
authors.initials: M
authors.lastname: Bonnefoy
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D010101:Oxygen Consumption; D010809:Physical Fitness; D012044:Regression Analysis
chemical_list: D008055:Lipids; D017270:Lipoprotein(a)