title: Surgical outcome in patients with coexisting multiple sclerosis and spondylosis.
abstract: OBJECTIVE
  Multiple sclerosis (MS) is a neuro-degenerative disease of unknown etiology which results in destruction of myelin. A variety of neurologic signs and symptoms are associated with MS and include myelopathy, extremity weakness, low back pain, sciatica and paresthesias. Many of these signs and symptoms are identical to those experienced by patients with spondylosis (e.g. spinal stenosis, disc herniations). The coexistence of MS with spondylosis can be problematic both for diagnosis and treatment.
  
  
  METHODS
  During the period 1992 to 1996 we identified 7 patients with previously diagnosed MS who developed new syndromes which were thought to be related to a variety of degenerative spine conditions. The diagnosis of MS was based on standard clinical, immunological and neuroradiological criteria.
  
  
  RESULTS
  Five of 7 patients demonstrated significant improvement after surgery. One patient experienced a transient MS exacerbation after surgery.
  
  
  CONCLUSIONS
  From our series we concluded that surgery for degenerative spine conditions can be performed in a safe and effective manner in patients with coexisting multiple sclerosis.
authors.affiliation: Department of Neurosurgery, Temple University Multiple Sclerosis Center, Philadelphia, PA, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Weaver
authors.forename: B
authors.initials: B
authors.lastname: Mishra
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis; D013128:Spinal Osteophytosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D013130:Spinal Stenosis / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome