title: Y-chromosome and mitochondrial DNA polymorphisms in Indian populations.
abstract: Y-chromosome polymorphism using short tandem repeat (STR) markers on 94 normal males belonging to the Brahmin and Kamma caste populations of Andhra Pradesh, India, and Siddis, a migrant population from Africa, inhabiting Hyderabad, India, revealed heterogeneity as indicated by network analysis. We have observed population-specific haplotypes and alleles. Analysis of Y-Alu polymorphism (YAP) in Siddis showed the presence of Alu insertion in 40% of the individuals. However, YAP insertion was not found in Brahmins and Kammas. The dendrogram based on hypervariable region I (HVR I) of the displacement loop (D-loop) sequence of mitochondrial DNA (mtDNA) of Siddis showed genetic relationships to African populations. YAP and mtDNA analysis of Siddis also confirmed their immigration from Africa.
authors.affiliation: Center for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: K
authors.initials: K
authors.lastname: Thangaraj
authors.forename: G V
authors.initials: GV
authors.lastname: Ramana
authors.forename: L
authors.initials: L
authors.lastname: Singh
mesh_terms: D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D017931:DNA Primers; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D006801:Humans; D007194:India; D008297:Male; D011110:Polymorphism, Genetic; D014998:Y Chromosome
chemical_list: D017931:DNA Primers; D004247:DNA