title: A quantitative trait locus for live weight maps to bovine chromosome 23.
abstract: A multiple-marker mapping approach was used to search for quantitative trait loci (QTLs) affecting production, health, and fertility traits in Finnish Ayrshire dairy cattle. As part of a whole-genome scan, altogether 469 bulls were genotyped for six microsatellite loci in 12 families on Chromosome (Chr) 23. Both multiple-marker interval mapping with regression and maximum-likelihood methods were applied with a granddaughter design. Eighteen traits, belonging to 11 trait groups, were included in the analysis. One QTL exceeded experiment level and one QTL genome level significance thresholds. Across-families analysis provided strong evidence (P(experiment) = 0.0314) for a QTL affecting live weight. The QTL for live weight maps between markers BM1258 and BoLA DRBP1. A QTL significant at genome level (P(genome) = 0.0087) was mapped for veterinary treatment, and the putative QTL probably affects susceptibility to milk fever or ketosis. In addition, three traits exceeded the chromosome 5% significance threshold: protein percentage of milk, calf mortality (sire), and milking speed. In within-family analyses, protein percentage was associated with markers in one family (LOD score = 4.5).
authors.affiliation: Agricultural Research Centre MTT, Animal Production Research, Animal Breeding, FIN-31600 Jokioinen, Finland.
authors.forename: K T
authors.initials: KT
authors.lastname: Elo
authors.forename: J
authors.initials: J
authors.lastname: Vilkki
authors.forename: D J
authors.initials: DJ
authors.lastname: de Koning
authors.forename: R J
authors.initials: RJ
authors.lastname: Velmala
authors.forename: A V
authors.initials: AV
authors.lastname: Mäki-Tanila
mesh_terms: D000483:Alleles; D000818:Animals; D001835:Body Weight / Q000235:genetics*; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D005260:Female; D005298:Fertility / Q000235:genetics; D005819:Genetic Markers; D007774:Lactation / Q000235:genetics; D016013:Likelihood Functions; D008297:Male; D008894:Milk Proteins / Q000032:analysis / Q000235:genetics; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis
chemical_list: D005819:Genetic Markers; D008894:Milk Proteins