Synthesis and antiviral activity of D- and L-isodideoxy nucleosides with exocyclic-methylene.
Novel D- and L-isodideoxynucleosides were synthesized starting from D- and L-xylose and evaluated for antiviral activities against HIV-1, HSV-1, HSV-2, HBV and HCMV, respectively.
Jeong
L S
LS
Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.
Yoo
S J
SJ
Moon
H R
HR
Chun
M W
MW
Lee
C K
CK
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008826:Microbial Sensitivity Tests
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D006838:Hydrocarbons; C030011:carbene; D008697:Methane