[The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6].
OBJECTIVE
The purpose of this study was to explore the responses of fibroblasts from keloids and normal skin to interleukin-1 beta and interleukin-6.


METHODS
Six samples of keloids and 6 samples of normal skin were collected as the experimental and control group respectively. The means of cell culture was used to investigate the responses of fibroblasts from three different parts of keloids and normal skin to interleukin-1 beta (200 U/ml) and interleukin-6 (100 U/ml).


RESULTS
Interleukin-1 beta could inhibit the growth of fibroblasts from the proliferative part of keloids but stimulate growth of those from normal skin, while it did not affect the growth of those from other parts of keloids. Fibroblasts from different parts of keloids and normal skin were all inhibited by interleukin-6.


CONCLUSIONS
The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6 were not much similar.
Xu
S
S
Research Center of Plastic Surgery, 3rd Clinical School of Beijing Medical University.
Wang
Z
Z
Bao
W
W
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology*; D007627:Keloid / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000166:cytology*
D007375:Interleukin-1; D015850:Interleukin-6