title: The relationship between c-erbB-2 oncogene expression and clinicopathological factors in gastric cancer.
abstract: Gastric carcinoma is one of the most common carcinomas and a leading cause of death from cancer in Turkey. The relationship between clinicopathological features of the disease and oncogenes is under investigation. In this retrospective study we investigated the relationships between expression of c-erbB-2 oncoprotein and grade, stage and pathological characteristics of the tumour, and prognosis. Formalin-fixed, paraffin-embedded tissue sections were prepared from gastrectomy specimens from 55 patients with gastric carcinoma. The tissue sections were stained immunohistochemically to reveal c-erbB-2 protein. Six (10%) of the tumours stained positively for c-erbB-2 protein. There was no statistically significant association (P > 0.5) between c-erbB-2 staining and tumour grade, stage or pathological characteristics (necrosis, lymph-node infiltration), or between staining and prognosis. The results suggest that overexpression of c-erb-B-2 protein is not related to the pathological characteristics of the tumour in gastric carcinoma and is not an important prognostic indicator.
authors.affiliation: Department of Gastroenterology, Medical School of Uludağ University, Bursa, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Gürel
authors.forename: E
authors.initials: E
authors.lastname: Dolar
authors.forename: O
authors.initials: O
authors.lastname: Yerci
authors.forename: B
authors.initials: B
authors.lastname: Samli
authors.forename: H
authors.initials: H
authors.lastname: Oztürk
authors.forename: S G
authors.initials: SG
authors.lastname: Nak
authors.forename: M
authors.initials: M
authors.lastname: Gülten
authors.forename: F
authors.initials: F
authors.lastname: Memik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D018734:Genes, erbB-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D015996:Survival Rate; D014421:Turkey
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases