Effects of an ionic and nonionic contrast agent on von Willebrand factor assessed during coronary angiography.
This study shows an increase in von Willebrand factor antigen in blood collected from the coronary sinus shortly after coronary angiography with an ionic contrast agent (diatrizoate), but not a nonionic contrast agent (iohexol). These findings suggest that ionic contrast agents may cause more endothelial injury than nonionic contrast agents.
Dehmer
G J
GJ
Center for Thrombosis and Hemostasis, Department of Medicine (Cardiology Division), University of North Carolina, Chapel Hill, USA. dehmer.car1@mail.unch.unc.edu
Nichols
T C
TC
Li
S
S
Koch
G G
GG
Tate
D A
DA
Griggs
T R
TR
D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography / Q000379:methods*; D003327:Coronary Disease / Q000097:blood / Q000000981:diagnostic imaging*; D003973:Diatrizoate / Q000494:pharmacology; D005260:Female; D006801:Humans; D007472:Iohexol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D014841:von Willebrand Factor / Q000032:analysis*
D003287:Contrast Media; D014841:von Willebrand Factor; D003973:Diatrizoate; D007472:Iohexol