Synthesis and biological activity of 5-azacytosine nucleosides derived from 4-thio-2-deoxy-L-threo-pentofuranose and 4-thio-2-deoxy-D-erythro-pentofuranose.
1-O-Acetyl-2-deoxy-3,5-di-O-toluoyl-4-thio-D-erythro-pentofuranose and 2-deoxy-1,3,5-tri-O-acetyl-4-thio-L-threo-pentofuranose were coupled with 5-azacytosine to obtain alpha and beta anomers of nucleosides.
Cappellacci
L
L
Southern Research Institute, Birmingham, AL 35255-5305, USA.
Tiwari
K N
KN
Montgomery
J A
JA
Secrist
J A
JA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D010429:Pentoses / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C120717:4-thio-2-deoxy-pentofuranose; D000970:Antineoplastic Agents; D010429:Pentoses; C039854:5-azacytosine; D003596:Cytosine