title: [Use of academician P.K.Anokhin's creative heritage for analysis of mechanisms responsible for homeostasis formation under microgravity].
abstract: The paper analyzes the changes occurring in the functions of the body's different systems under microgravitation in the context of current views on homeostasis and of the Anokhin's theory of functional systems. Proceeding from the Anokhin's views, the authors consider the specific features of a conceptual model for formation of the functional system of homeostatic regulation under microgravitation. These concepts were used to examine the body's homeostatic responses under the conditions of microgravitation which are associated with changes in the sensory input, with the movement of fluids in the cranial direction and with the removal of weight burden on the locomotor apparatus. Gravity withdrawal was demonstrated to lead to the development of homeostatic changes which are followed by consecutive trigger of prompt and long-term adaptation responses. This yields a new functional system of homeostatic regulation and a new rather relatively permanent functioning of the body's basic systems.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigor'ev
authors.forename: A D
authors.initials: AD
authors.lastname: Egorov
authors.forename: I B
authors.initials: IB
authors.lastname: Kozlovskaia
mesh_terms: D049673:History, 20th Century; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D010827:Physiology / Q000266:history / Q000379:methods*; D013598:Systems Theory; D014893:Weightlessness
vernacular_title: Ispol'zovanie tvorcheskogo naslediia akademika P.K.Anokhina dlia analiza mekhanizmov formirovaniia gomeostaza v usloviiakh mikrogravitatsii.