title: The spiroketals containing a benzyloxymethyl moiety at C8 position showed the most potent apoptosis-inducing activity.
abstract: The spiroketals containing a benzyloxymethyl moiety at the C8 position showed the most potent apoptosis-inducing activity, whereas its analogous compounds lacking any substituent at C8 or possessing ones other than the benzyloxymethyl moiety at C8 were all much less active. These results strongly suggest an important role of the benzyloxymethyl moiety linked to the C8 oxygen atom.
authors.affiliation: Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mitsuhashi
authors.forename: H
authors.initials: H
authors.lastname: Shima
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Oikawa
authors.forename: A
authors.initials: A
authors.lastname: Ichihara
authors.forename: H
authors.initials: H
authors.lastname: Oikawa
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation; D006801:Humans; D019169:Jurkat Cells / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D019319:Okadaic Acid / Q000737:chemistry; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology*; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011714:Pyrans; D013141:Spiro Compounds; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases