Relationship between kidney size, renal injury, and renal impairment induced by shock wave lithotripsy.
The relationship between kidney size and impaired renal function induced by shock-wave lithotripsy (SWL) was examined in 6- and 10-wk-old anesthetized pigs. Each pig received 2000 shock waves, 24 kV, or sham SWL to the lower pole calyx of one kidney. Bilateral GFR, renal plasma flow (RPF), and para-aminohippurate extraction was measured 1 h before and 1 and 4 h after SWL. The kidneys were then removed for morphometric analysis. Mean kidney weights were 66.1+/-2.7 g (n = 9) and 103.1+/-3.3 g (n = 8) in the SWL groups, and 60.1+/-2.6 g (n = 9) and 82.3+/-4.0 g (n = 9) in the sham-SWL groups. SWL-induced lesions occupied a significantly greater volume of the small kidneys (6.1+/-1.7 vol % versus 1.5+/-0.2 vol% in the large kidneys). RPF was significantly reduced by SWL in small and large kidneys, but to a significantly greater extent in small kidneys. RPF was also significantly reduced in the contralateral kidneys of both groups, but only at 1 h after SWL. SWL significantly reduced GFR to similar degrees in both kidneys of both groups, regardless of kidney size. Para-aminohippurate extraction was likewise reduced to similar degrees in both groups, but this effect was evident only in the SWL-treated kidneys, and only in the pole to which the shock waves had been applied. The injury induced by SWL affected a larger fraction of small kidneys than large ones, and the renal vasoconstriction induced by SWL was greatest in small kidneys.
Willis
L R
LR
Department of Pharmacology and Toxicology, School of Medicine, Indiana University, Indianapolis 46202, USA. willis@iupui.edu
Evan
A P
AP
Connors
B A
BA
Blomgren
P
P
Fineberg
N S
NS
Lingeman
J E
JE
D000818:Animals; D005260:Female; D007668:Kidney / Q000033:anatomy & histology* / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008096:Lithotripsy / Q000009:adverse effects*; D009929:Organ Size / Q000502:physiology; D012082:Renal Veins; D013552:Swine; D010130:p-Aminohippuric Acid / Q000097:blood / Q000378:metabolism
D010130:p-Aminohippuric Acid