Early neocortical regionalization in the absence of thalamic innervation.
There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions.
Miyashita-Lin
E M
EM
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0984, USA.
Hevner
R
R
Wassarman
K M
KM
Martinez
S
S
Rubenstein
J L
JL
D000818:Animals; D001369:Axons / Q000737:chemistry / Q000502:physiology*; D015820:Cadherins / Q000235:genetics; D064032:Calbindin 2; D002232:Carbocyanines; D004268:DNA-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D051796:Inhibitor of Differentiation Proteins; D051821:Lymphoid Enhancer-Binding Factor 1; D051379:Mice; D009154:Mutation; D019579:Neocortex / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D009412:Nerve Fibers / Q000502:physiology / Q000648:ultrastructure; D011506:Proteins / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D044094:Receptors, Melatonin; D064030:S100 Calcium Binding Protein G / Q000032:analysis; D013254:Steroid 17-alpha-Hydroxylase / Q000032:analysis; D013687:Telencephalon / Q000196:embryology / Q000254:growth & development / Q000502:physiology; D013788:Thalamus / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
D015820:Cadherins; D064032:Calbindin 2; D002232:Carbocyanines; D004268:DNA-Binding Proteins; C513182:Gbx2 protein, mouse; D018398:Homeodomain Proteins; C086479:Idb4 protein, mouse; D051796:Inhibitor of Differentiation Proteins; D051821:Lymphoid Enhancer-Binding Factor 1; D011506:Proteins; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D064030:S100 Calcium Binding Protein G; D014157:Transcription Factors; C024286:3,3'-dioctadecylindocarbocyanine; D013254:Steroid 17-alpha-Hydroxylase; C087310:K cadherin