title: Insulin sensitivity measured with the minimal model is higher in moderately overweight women with predominantly lower body fat.
abstract: Lower-body obesity is associated with a lower incidence of diabetes and high values of HDL2 cholesterol and thus seems to have a metabolic profile opposite to upper-body obesity. We measured insulin sensitivity by the minimal model procedure in 20 lower-body overweight women (age 40.3+/-2.3 years, waist-to-hip ratio WHR 0.75+/-0.01, body mass index BMI 29.9+/-0.7 kg/m2), compared to 18 women with a similar degree of upper-body obesity (age 40.4+/-3years, WHR 0.91+/-0.02, BMI 29.4+/-0.7 kg/m2) and 28 control women matched for age and height. Insulin sensitivity and basal insulin effect were higher in lower-body obesity (11.2+/-0.2 min-1/[microU/ml]x 10(-4) and 0.8+/-0.2 min(-1) x 10(-2), respectively) compared to upper-body obesity (2.6+/-0.4, p < 0.001 and 0.3+/-0.05, p < 0.01) and controls (6.1+/-0.7, p < 0.02 and 0.5+/-0.07, p < 0.02). It is suggested that lower-body obesity could be associated with a reduced free fatty acids-induced inhibition of insulin action by the Randle mechanism. This study confirms that body fat distribution is a more relevant determinant than obesity itself in the pathogenesis of insulin resistance. Contrary to upper-body obesity, moderate lower-body overweight seems to be associated with high values on insulin sensitivity.
authors.affiliation: CERAMM, Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Montpellier, France.
authors.forename: E
authors.initials: E
authors.lastname: Raynaud
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Martin
authors.forename: J F
authors.initials: JF
authors.lastname: Brun
authors.forename: C
authors.initials: C
authors.lastname: Fédou
authors.forename: J
authors.initials: J
authors.lastname: Mercier
mesh_terms: D000328:Adult; D005260:Female; D005951:Glucose Tolerance Test; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000378:metabolism*
chemical_list: D012739:Gonadal Steroid Hormones