Monosomy 22 and trisomy 14 may be early events in the tumorigenesis of adult granulosa cell tumor.
The finding of monosomy 22 and trisomy 14 in a case of adult type of granulosa-thecoma cell tumor and the available information from the literature allow for the hypothesis that, especially monosomy 22, but also trisomy 14, may be early events in the tumorigenesis of adult sex cord-stromal tumors in general, and of granulosa-thecoma cell tumors in particular.
Van den Berghe
I
I
Center for Pathology, University of Leuven, Belgium.
Dal Cin
P
P
De Groef
K
K
Michielssen
P
P
Van den Berghe
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002883:Chromosomes, Human, Pair 14; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006106:Granulosa Cell Tumor / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009006:Monosomy; D014314:Trisomy