Anti-HIV pronucleotides: SATE versus phenyl as a protecting group of AZT phosphoramidate derivatives.
We comparatively studied the decomposition pathways in CEM cell extract of several PHENYL phosphoramidate diesters of AZT. A correlation between anti-HIV activities in TK- cell lines and pharmacokinetic data has been observed. This study would help to design corresponding SATE phosphoramidate diesters which revealed potent anti-HIV properties.
Beltran
T
T
Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, France.
Egron
D
D
Lefebvre
I
I
Périgaud
C
C
Pompon
A
A
Gosselin
G
G
Aubertin
A M
AM
Imbach
J L
JL
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D009943:Organophosphorus Compounds / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D019380:Anti-HIV Agents; D009943:Organophosphorus Compounds; D015215:Zidovudine