title: Loss of the Y-chromosome in the primary metastasis of a male sex cord stromal tumor: pathogenetic implications.
abstract: The first published chromosomal pattern of the retroperitoneal lymph node metastasis of a malignant gonadal stroma cell tumor of the adult testis is presented. Karyotyping showed structural chromosomal abnormalities and loss of the Y-chromosome. This loss was confirmed in primary tumor and metastasis using fluorescence in situ hybridization (FISH). The characteristic chromosomal abnormality of adult testicular germ cell tumors, an i(12p), was not present. The results are compared with other data of testicular and ovarian sex cord stromal tumors. From the comparison of the male tumors, it is concluded that loss of the Y-chromosome might have a pathogenetic significance.
authors.affiliation: Department of Medical Oncology, University Hospital of Groningen, The Netherlands.
authors.forename: W E
authors.initials: WE
authors.lastname: de Graaff
authors.forename: J
authors.initials: J
authors.lastname: van Echten
authors.forename: A Y
authors.initials: AY
authors.lastname: van der Veen
authors.forename: D T
authors.initials: DT
authors.lastname: Sleijfer
authors.forename: A
authors.initials: A
authors.lastname: Timmer
authors.forename: H
authors.initials: H
authors.lastname: Schraffordt Koops
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D002872:Chromosome Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008207:Lymphatic Metastasis; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D018312:Sex Cord-Gonadal Stromal Tumors / Q000235:genetics* / Q000473:pathology; D014998:Y Chromosome