Dehalogenases applied to industrial-scale biocatalysis.
In the recent past, the development of dehalogenating enzymes for industrial biocatalysis has been limited, but significant advances have been made. Three classes of enzymes have received attention and development: halalkanoic acid dehalogenases (EC 3.8.1.2), hydrogen-halide lyases (EC 4.5.1), and haloalkane dehalogenases (EC 3.8.1). Applications range from the manufacture of chiral intermediates, to recycling of chlorinated byproducts from chemical manufacturing, and selective treatment of process waste streams.
Swanson
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PE
The Dow Chemical Company, Corporate Research and Development, Building 1707, Midland, MI 48674, USA. biocatswanson@dow.com
D001673:Biodegradation, Environmental; D001709:Biotechnology; D002384:Catalysis; D004785:Environmental Pollutants / Q000378:metabolism; D004800:Enzymes, Immobilized; D006846:Hydrocarbons, Halogenated / Q000378:metabolism*; D006867:Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008190:Lyases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D004785:Environmental Pollutants; D004800:Enzymes, Immobilized; D006846:Hydrocarbons, Halogenated; D006867:Hydrolases; C034507:2-haloacid dehalogenase; D008190:Lyases