title: [Myocardial function after fluid resuscitation with addition of anisodamine in severely burned rabbits].
abstract: OBJECTIVE
  To evaluate the effect of fluid resuscitation with addition of anisodamine (Ani) on myocardial function in severely burned rabbits.
  
  
  METHODS
  III degree burn injury covering 25% total body surface area (TBSA) was produced on rabbits. LVSP, LV +/- dp/dtmax were measured with fluid resuscitation alone, administration of Ani alone, and fluid resuscitation plus Ani before burn, immediately after burn and 1, 3, 5, 7 h after burn.
  
  
  RESULTS
  It was showed that myocardial contractility and relaxation were depressed 1 h after burn. Fluid resuscitation alone and administration of Ani alone could significantly improve myocardial contractility and relaxation only within 3 h postburn. With fluid resuscitation plus Ani (5 mg.kg-1), myocardial contractility and relaxation were improved statistically significantly as compared with control group without treatment (P < 0.01), with the values approaching the normal level.
  
  
  CONCLUSIONS
  Our data demonstrate that the administration of Ani (5 mg.kg-1) in addition to fluid resuscitation is beneficial to burn injury, especially to myocardial function, and it provides a promising approach for the future treatment of burns.
authors.affiliation: Department of Pharmacology, Fourth Military Medical University, Xi'an.
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: D
authors.initials: D
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine