Role of calcium-independent phospholipase A2 in the regulation of calcium influx into Jurkat cells.
The role of phospholipases A2 in calcium metabolism is briefly reviewed. Some data are presented indicating that calcium-independent phospholipase A2 may modify the activity of store-activated calcium channels in the plasma membrane of Jurkat cells. Helss, a specific inhibitor of calcium-independent phospholipase A2 blocks the store-operated signal that is transmitted from ER to the plasma membrane.
Zabłocki
K
K
Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.
Duszyński
J
J
D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D019169:Jurkat Cells; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D009281:Naphthalenes / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D054467:Phospholipases A2; D011753:Pyrones / Q000494:pharmacology*
D015220:Calcium Channels; D009281:Naphthalenes; D010726:Phosphodiesterase Inhibitors; D011753:Pyrones; C068314:6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one; D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium