Lipoprotein(a): intrigues and insights.
Lipoprotein(a) is an atherogenic, cholesterol ester-rich lipoprotein of unknown physiological function. The unusual species distribution of lipoprotein(a) and the extreme polymorphic nature of its distinguishing apolipoprotein component, apolipoprotein(a), have provided unique challenges for the investigation of its biochemistry, genetics, metabolism and atherogenicity. Some fundamental questions regarding this enigmatic lipoprotein have escaped elucidation, as will be highlighted in this review.
Hobbs
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Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235, USA. helen.hobbs@email.swmed.edu
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D000818:Animals; D030801:Animals, Genetically Modified; D001053:Apolipoproteins / Q000235:genetics; D053241:Apoprotein(a); D001161:Arteriosclerosis / Q000097:blood; D005075:Biological Evolution; D002986:Clinical Trials as Topic; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000502:physiology
D001053:Apolipoproteins; D017270:Lipoprotein(a); D053241:Apoprotein(a)