title: [Neurohumoral changes in patients with mild and moderate forms of hypertension under the influence of losartan].
abstract: The article presents data on effects of losartan (Cozaar of the Merck-Sharp-Dohme firm, USA) on neurohumoral indices in patients with mild to moderate forms of hypertension. Apart from optimum hypotensive effect and modulating influence on morphofunctional parameters of the heart losartan was found to be endowed with a broad spectrum of neurohumoral effects (reduction in the ejection of catecholamines, natriuretic hormone, stabilization of indices for the renin-angiotensin system etc.). Moreover, the given drug preparation does not have appreciable effect on the activity of the kallikrein-kinin system, by which property it differs favourably from angiotensin-converting enzyme inhibitors.
authors.forename: S N
authors.initials: SN
authors.lastname: Koval'
authors.forename: A N
authors.initials: AN
authors.lastname: Belovol
authors.forename: D K
authors.initials: DK
authors.lastname: Miloslavskiĭ
authors.forename: L V
authors.initials: LV
authors.lastname: Masliaeva
authors.forename: O V
authors.initials: OV
authors.lastname: Mysnichenko
mesh_terms: D000328:Adult; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood*; D013997:Time Factors
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D018377:Neurotransmitter Agents; D019808:Losartan
vernacular_title: Neĭrogumoral'nye izmeneniia u bol'nykh s miagkoĭ i umerennoĭ formami gipertonicheskoĭ bolezni pod vliianiem lozartana.