title: Pulmonary arterial Doppler velocimetry in fetuses with lung hypoplasia.
abstract: OBJECTIVE
  The aim of the study was to examine Doppler flow velocity waveforms in the main stems of the pulmonary arteries in fetuses with autopsy-proven lung hypoplasia and to find out whether in these conditions typical patterns can be found.
  
  
  METHODS
  Doppler spectra were derived from the main stem of the right or left pulmonary artery in fetuses at high-risk for lung-hypoplasia. The following Doppler parameters were analyzed and compared to reference ranges: peak systolic velocity, acceleration time, time velocity integral, end-systolic reverse flow, pulsatility index (PI). Pulmonary hypoplasia was found in nine cases at autopsy after termination of pregnancy (19-23 weeks). According to etiology, three groups were considered: (A) bilateral renal malformations (n=4), (B) congenital diaphragmatic hernia (n=2), and (C) miscellaneous malformations including heart defects (n=3).
  
  
  RESULTS
  The following Doppler parameters were found: normal values in end-systolic reversal flow in all cases, decreased peak systolic velocity and acceleration time in 3/9, decreased time velocity integral in 4/9 and increased pulsatility index in 6/9. Considering the etiology of pulmonary hypoplasia the pulsatility index was found to be the most sensitive, since all fetuses in groups A and B had an abnormal PI.
  
  
  CONCLUSIONS
  Human fetuses with renal malformations and diaphragmatic hernia associated with lung hypoplasia show as early as 19-23 weeks of gestation an abnormal Doppler spectrum in the main stems of the pulmonary arteries. Increased PI is the best parameter to detect flow abnormality in this condition. Since the Doppler spectrum depends on cardiac anatomy and function, PI in lung hypoplasia seems to be reliable only when cardiac defects are absent.
authors.affiliation: Department of Obstetrics & Gynaecology, Charité Hospital, Berlin, Germany. chaoui@charite.de
authors.forename: R
authors.initials: R
authors.lastname: Chaoui
authors.forename: K
authors.initials: K
authors.lastname: Kalache
authors.forename: C
authors.initials: C
authors.lastname: Tennstedt
authors.forename: F
authors.initials: F
authors.lastname: Lenz
authors.forename: M
authors.initials: M
authors.lastname: Vogel
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000002:abnormalities* / Q000098:blood supply*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000502:physiology* / Q000503:physiopathology; D018615:Ultrasonography, Doppler, Color; D018617:Ultrasonography, Doppler, Pulsed; D016216:Ultrasonography, Prenatal