Partial monosomy of distal 10q: three new cases and a review.
We report on 3 patients with partial deletions of the long arm of chromosome 10-46,XY,del (10)(q26.2), 46,XX,del(10) (q25.3q26.3) or 46,XX,del(10)(q26.1), and 46,XX,del (10)(q26.1). They are compared with other known cases with interstitial or terminal deletions involving chromosome bands 10q25 or q26. Unique manifestations are identified, including scoliosis and a severe behavior disorder with attention deficit and hyperactivity in a 12-year-old boy as well as patchy alopecia in a 6-year-old patient.
Waggoner
D J
DJ
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA.
Chow
C K
CK
Dowton
S B
SB
Watson
M S
MS
D000015:Abnormalities, Multiple / Q000235:genetics; D002648:Child; D019457:Chromosome Breakage / Q000235:genetics; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005260:Female; D006331:Heart Diseases / Q000151:congenital / Q000235:genetics; D006801:Humans; D008297:Male; D009006:Monosomy / Q000235:genetics*; D010641:Phenotype; D012733:Sex Differentiation / Q000235:genetics