title: Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
abstract: We have investigated the effects of several beta-D-ddA 5'-monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers prodrugs against HBV replication. All ddAMP prodrugs inhibited HBV replication in a dose-dependent manner.
authors.affiliation: Department of Pharmacology, Univ. of Alabama at Birmingham, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Loi
authors.forename: A
authors.initials: A
authors.lastname: Faraj
authors.forename: C
authors.initials: C
authors.lastname: Pierra
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: S A
authors.initials: SA
authors.lastname: Locarnini
authors.forename: E V
authors.initials: EV
authors.lastname: Groman
authors.forename: R F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: J P
authors.initials: JP
authors.lastname: Sommadossi
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003838:Deoxyadenine Nucleotides / Q000494:pharmacology*; D054306:Dideoxynucleotides; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D019259:Lamivudine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003838:Deoxyadenine Nucleotides; D054306:Dideoxynucleotides; C010110:2',3'-dideoxyadenosine 5'-phosphate; D019259:Lamivudine