Observational study of maternal anthropometry and fetal insulin.
OBJECTIVE
To examine the relation between maternal body fat and fetal metabolism.


METHODS
In this observational study, cord blood samples were collected from 60 infants of healthy women for the measurement of insulin and C peptide concentrations. Maternal weight, height, body mass index (BMI) and body composition (skinfold thickness measurements and bioelectrical impedance) were assessed at 13-15 weeks of gestation. Twenty five of the volunteers agreed to have a 75 g oral glucose tolerance test at 28-31 weeks of gestation.


RESULTS
Positive correlations were observed with both cord insulin or C peptide concentrations and maternal early pregnancy BMI (r=0.44, p=0.002 and r=0.33, p=0.008, respectively). There was no significant correlation between cord insulin or C peptide concentrations and birthweight or birth weight centiles.


CONCLUSIONS
Maternal BMI could be a predictor of fetal cord insulin concentration.
Soltani-K
H
H
University Department of Obstetrics and Gynaecology Northern General Hospital Sheffield. h.soltani@sheffield.ac.uk
Bruce
C
C
Fraser
R B
RB
D000886:Anthropometry; D001724:Birth Weight / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood*; D008297:Male; D011247:Pregnancy / Q000097:blood / Q000502:physiology*
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin