Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II.
We investigated whether a lipoxygenase inhibitor, panaxynol, affected the vascular contraction induced by angiotensin (Ang) II and the mean arterial pressure in spontaneously hypertensive rats (SHR). Panaxynol suppressed dose-dependently the contractile responses induced by 30 nM Ang II in isolated intact and endothelial cell-denuded aorta in the hamster. IC50 values in the intact and endothelial cell-denuded aorta were 23 and 20 microM, respectively. In SHR, the mean arterial pressure after injection of 30 and 60 mg/kg panaxynol was reduced, and the maximum hypotensive values were 23 and 48 mmHg, respectively. Thus, lipoxygenase products may affect the renin-angiotensin system.
Takai
S
S
Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.
Jin
D
D
Kirimura
K
K
Ikeda
J
J
Sakaguchi
M
M
Baba
K
K
Fujita
T
T
Miyazaki
M
M
D000480:Alkynes; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006224:Cricetinae; D004195:Disease Models, Animal; D053280:Diynes; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D005233:Fatty Alcohols / Q000494:pharmacology* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D000480:Alkynes; D053280:Diynes; D005233:Fatty Alcohols; D016859:Lipoxygenase Inhibitors; D000804:Angiotensin II; C018541:falcarinol