title: The common bacterial toxins hypothesis of sudden infant death syndrome.
abstract: The background to the common bacterial toxin hypothesis of sudden infant death syndrome is presented. The idea is that some cases of sudden infant death syndrome are due to the lethal effects of nasopharyngeal bacterial toxins which can act synergistically to trigger the events leading to death. The concept is consistent with the age distribution of sudden infant death syndrome, the winter excess of cases and the role of prone sleeping and passive exposure to cigarette smoke. A number of laboratory-based investigations are described. There is an increased isolation of staphylococci and Gram-negative bacilli from sudden infant death syndrome infants compared with age- and season-matched healthy infants. Bacteria from sudden infant death syndrome infants interact synergistically to cause sudden death in gnotobiotic weanling rats. Bacterial toxins implicated in sudden infant death syndrome interact synergistically to cause death in chick embryos. Nicotine in very low doses potentiates the lethal effect of toxin combinations in chick embryos. Staphylococcal toxins and endotoxins have been demonstrated in sudden infant death syndrome tissues, antibodies to endotoxins are low in sudden infant death syndrome cases and the prone sleeping position leads to pooling of secretions in the upper airways, increasing the risk of bacterial growth and toxin production. If the hypothesis is correct, then there is the possibility of a further reduction in the incidence of sudden infant death syndrome based on immunisation against the toxins involved.
authors.affiliation: Royal Lancaster Infirmary, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Morris
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D001424:Bacterial Infections / Q000150:complications* / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051381:Rats; D012106:Research; D012890:Sleep; D013398:Sudden Infant Death / Q000453:epidemiology / Q000209:etiology*
chemical_list: D001427:Bacterial Toxins