[Muscle cramps: reevaluation of the effectiveness of quinine salts].
COMMONLY PRESCRIBED DRUGS: The official French regulatory indication for quinine salts simply states that they can be used as supplementary therapy for nighttime muscle cramps. This type of statement does not indicate a high level of proof of efficacy. Quinine salts are widely prescribed in developed countries. SECONDARY EFFECTS: Drug monitoring surveys have recorded severe adverse effects, particularly sometimes fatal thrombocytopenia. EFFICACITY REVISITED: In this context, we present a critical review of 10 comparative randomized double-blind clinical trials conducted since 1983 and of a meta-analysis published in 1995. The results of these studies are rather difficult to interpret and sometimes contradictory. When an effect is evidenced, it is incomplete and only concerns the number of cramps experienced with no effect on severity or duration. In addition, no precise information is available concerning dose, optimal treatment duration and relapse. Consequently, an irrefutable demonstration of the efficacy of this type of product is still lacking.
Villani
P
P
Laboratoire de Thérapeutique et de Méthodologie des Essais cliniques, Faculté de Médecine de Marseille.
Mugnier
B
B
Bouvenot
G
G
D004305:Dose-Response Relationship, Drug; D006801:Humans; D015201:Meta-Analysis as Topic; D009120:Muscle Cramp / Q000188:drug therapy*; D011803:Quinine / Q000008:administration & dosage* / Q000494:pharmacology; D012492:Salts
D012492:Salts; D011803:Quinine
Crampes musculaires: réévaluation de l'efficacité des sels de quinine.