Effect of verbascoside on decreasing concentration of oxygen free radicals and lipid peroxidation in skeletal muscle.
OBJECTIVE
To detect the effects of verbascoside on decreasing the concentration of oxygen free radicals (OFR) and lipid peroxidation in skeletal muscle resulting from exhaustive exercise.


METHODS
Electron spin resonance (ESR) technique and thiobarbituric acid reaction (TBAR) method were used to detect the concentration of OFR in intact gastrocnemius muscle and the contents of milondialdehyde (MDA) in muscle homogenate.


RESULTS
Verbascoside decreased the concentration of OFR (P < 0.05) and the level of lipid peroxidation (P < 0.05) in muscle caused by exercise.


CONCLUSIONS
Verbascoside has the effects of reducing oxidative stress in muscle caused by exhaustive exercise by decreasing the concentration of free radicals and the level of lipid peroxidation.
Li
J X
JX
Department of Orthopedics & Traumatology, Chinese University of Hong Kong, China. lijx@HKSDB.ORG.HK
Xin
D
D
Li
H
H
Lu
J F
JF
Tong
C W
CW
Gao
J N
JN
Chan
K M
KM
D000818:Animals; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D005960:Glucosides / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010636:Phenols; D005082:Physical Exertion; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D059808:Polyphenols
D016166:Free Radical Scavengers; D005609:Free Radicals; D005960:Glucosides; D008315:Malondialdehyde; D010100:Oxygen; D010636:Phenols; C058956:acteoside; D059808:Polyphenols