title: Incidence of sperm aneuploidy in relation to semen characteristics and assisted reproductive outcome.
abstract: OBJECTIVE
  To evaluate the incidence of sperm aneuploidy in men screened for infertility and identify any eventual relation with assisted reproductive outcome.
  
  
  METHODS
  Controlled prospective study.
  
  
  METHODS
  University hospital-based IVF program.
  
  
  METHODS
  Infertile couples who were screened for sperm aneuploidy and evaluated for IVF treatment.
  
  
  METHODS
  Fluorescence in situ hybridization was used to identify chromosomes 18, 21, X, and Y. The assisted reproductive techniques of IVF and intracytoplasmic sperm injection were used for infertility treatment.
  
  
  METHODS
  The incidence of sperm aneuploidy, semen parameters, fertilization rate, pregnancy characteristics, and rate of neonatal malformations were determined.
  
  
  RESULTS
  Oligozoospermic and teratozoospermic men had a significantly higher incidence of chromosomal abnormalities than men with normal semen parameters (2.7% vs. 1.8%). The increased frequency of sperm aneuploidy did not appear to affect pregnancy losses or the occurrence of neonatal malformations.
  
  
  CONCLUSIONS
  Suboptimal semen samples had a higher incidence of aneuploidy. In this study, the increased frequency of chromosomal abnormalities did not have a direct effect on the fertilization rate, pregnancy characteristics, or neonatal outcome.
authors.affiliation: The Center for Reproductive Medicine and Infertility, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York 10021, USA.
authors.forename: L T
authors.initials: LT
authors.lastname: Colombero
authors.forename: J J
authors.initials: JJ
authors.lastname: Hariprashad
authors.forename: M C
authors.initials: MC
authors.lastname: Tsai
authors.forename: Z
authors.initials: Z
authors.lastname: Rosenwaks
authors.forename: G D
authors.initials: GD
authors.lastname: Palermo
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002887:Chromosomes, Human, Pair 18 / Q000187:drug effects / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000187:drug effects / Q000235:genetics; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015994:Incidence; D008297:Male; D009845:Oligospermia / Q000235:genetics; D018873:Pregnancy Rate; D011446:Prospective Studies; D012661:Semen / Q000166:cytology*; D013094:Spermatozoa / Q000002:abnormalities*; D014960:X Chromosome / Q000187:drug effects / Q000235:genetics; D014998:Y Chromosome / Q000187:drug effects / Q000235:genetics