Synthesis of isoxazolidino analogues of 2',3'-dideoxynucleosides.
The complete set of the 4'-aza analogues of 2',3'-dideoxynucleosides was synthesized by cycloaddition of N-tetrahydropiranyl or N-trityl methylene nitrones on suitably protected vinyl nucleobases. The convertible nucleoside approach was used in the preparation of cytosine and 5-methyl cytosine analogues.
Colacino
E
E
Dipartimento di Chimica, Università della Calabria.
Converso
A
A
De Nino
A
A
Leggio
A
A
Liguori
A
A
Maiuolo
L
L
Napoli
A
A
Procopio
A
A
Siciliano
C
C
Sindona
G
G
D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D010080:Oxazoles / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
D015224:Dideoxynucleosides; D010080:Oxazoles