title: Length-dependent regulation of left ventricular function in coronary surgery patients.
abstract: BACKGROUND
  Load-dependent impairment of left ventricular (LV) function was observed after leg elevation in a subgroup of coronary surgery patients. The present study investigated underlying mechanisms by comparing hemodynamic effects of an increase in LV systolic pressures with leg elevation to effects of a similar increase in systolic pressures with phenylephrine.
  
  
  METHODS
  The study was performed in patients undergoing elective coronary surgery prior to cardiopulmonary bypass. High-fidelity LV pressure tracings (n = 25) and conductance LV volume data (n = 10) were obtained consecutively during leg elevation and after phenylephrine administration (5 microg/kg).
  
  
  RESULTS
  Leg elevation resulted in a homogeneous increase in end-diastolic volume. The change in stroke volume (SV), stroke work (SW) and dP/dtmax was variable, with an increase in some patients but no change or a decrease in other patients. For a matched increase in systolic pressures, phenylephrine increased SW and dP/dtmax in all patients with no change in SV. Load dependence of relaxation (slope R of the tau-end-systolic pressure relation) was inversely related for changes in SV, SW, and dP/dtmax with leg elevation but not with phenylephrine.
  
  
  CONCLUSIONS
  The different effects of leg elevation and phenylephrine suggest that the observed decrease in SV, SW, and dP/dtmax with leg elevation in some patients could not be attributed to an impaired contractile response to increased systolic LV pressures. Instead, load-dependent impairment of LV function after leg elevation appeared related to a deficient length-dependent regulation of myocardial function.
authors.affiliation: Department of Anesthesiology, University Hospital Antwerp, Edegem, Belgium. sdehert@uia.ac.be
authors.forename: S G
authors.initials: SG
authors.lastname: De Hert
authors.forename: T C
authors.initials: TC
authors.lastname: Gillebert
authors.forename: P W
authors.initials: PW
authors.lastname: Ten Broecke
authors.forename: A C
authors.initials: AC
authors.lastname: Moulijn
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D010656:Phenylephrine / Q000494:pharmacology; D013599:Systole / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D010656:Phenylephrine