Metabolism of quercitrin by human intestinal bacteria and its relation to some biological activities.
When quercitrin was anaerobically incubated with human intestinal bacteria, quercetin, 3,4-dihydroxyphenylacetic acid and 4-hydroxybenzoic acid were found as metabolites. The main metabolite was quercetin. The bacterium transforming quercitrin to quercetin was Fusobacterium K-60. However, Bacteroides JY-6, which produced alpha-L-rhamnosidase, did not transform quercitrin to quercetin. Among quercitrin and its metabolites, 3,4-dihydroxyphenylacetic acid and 4-hydroxylphenylacetic acid had more potent activity than quercitrin on in vitro anti-platelet aggregation activity, and quercetin and 3,4-dihydroxyphenylacetic acid showed more potent cytotoxicity against tumor cell lines than quercitrin and 4-hydroxylphenylacetic acid.
Kim
D H
DH
College of Pharmacy, Kyung-Hee University, Seoul, Korea.
Kim
S Y
SY
Park
S Y
SY
Han
M J
MJ
D000930:Antidiarrheals / Q000378:metabolism* / Q000494:pharmacology; D005673:Fusobacterium / Q000187:drug effects / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D000930:Antidiarrheals; D010975:Platelet Aggregation Inhibitors; C012526:quercitrin; D011794:Quercetin; D006026:Glycoside Hydrolases; C022525:alpha-L-rhamnosidase