title: [Clinical and pathological characteristics in Chinese patients with pauci-immune crescentic glomerulonephritis].
abstract: We investigated pauci-immune crescentic glomerulonephritis (PICGN) in Chinese patients, During 11 years (1985-1996), 5,800 patients underwent renal biopsy in Nanjing Jinling Hospital. Eighteen patients were diagnosed as having PICGN. They were 11 women and 7 men with median age of 29 (range 10-71 years). Polyarteritis (33.3%) and polyarteritis nodosa (11.1%) were the secondary diseases. The incidence of PICGN was 0.31% in renal biopsies and 23.10% in crescentic glomerulonephritis. Clinically, most patients (83.3%) showed rapidly progressive nephritis with enlarged kidneys. Gross hemoturia was noted in 61.1% patients, hypertension 44.4%, nephrotic syndrome 44.4%, and oligria 33.3%. However, systemic symptoms were rare except anemia. Pathologically, we observed necrosis of glomerular capillaries (61.1%), infiltration of monocytes and neutrophil cells in glomeruli (44.4%), and vasculitis in interstitium (55.5%), in addition to glomerulosclerosis (44.4%), severe tubular atrophy (83.3%) and interstitial fibrosis (72.2%). Antineutrophil cytoplasmic antibodies (ANCA) was positive in 41.7%. All patients except one received intensively immunosuppressive therapy. 12 patients were subjected to long-term follow up (median 25.9, range 8-72 months). Only three patients were dialysis-dependent, while none died.
authors.affiliation: Department of Nephrology, Jinling Hospital, Nanjing University, School of Medicine.
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: W
authors.initials: W
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001706:Biopsy; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000209:etiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic