[A case of recurrent colon cancer with complete response to modulation chemotherapy using low-dose leucovorin and 5-fluorouracil].
We experienced a case of lymph node recurrence from colon cancer with complete response to modulation chemotherapy using low-dose leucovorin and 5-FU. The patient was a 68-year-old male. He underwent sigmoid colon resection for sigmoid colon cancer in October 1993. In June 1994, he complained of left lower abdominal pain. Swelling of retroperitoneal lymph node was detected by CT scan and cytology revealed cancer cells in urine. He was diagnosed as having lymph node recurrence. He then was given modulation chemotherapy of 30 mg of leucovorin and 500 mg of 5-FU that were bolus injected intravenously for 5 days. After 2 cycles of this regimen, the recurrent mass disappeared completely for further examination. Until May 1998, he had received 14 cycles. Since this regimen started, his survival period has been 46 months, and his response duration 42 months.
Umehara
A
A
Dept. of Surgery, Tokyo Women's Medical University Daini Hospital.
Kato
H
H
Takahashi
N
N
Endo
S
S
Yoshimatsu
K
K
Hashimoto
M
M
Haga
S
S
Kajiwara
T
T
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D012809:Colon, Sigmoid / Q000601:surgery; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D007275:Injections, Intravenous; D002955:Leucovorin / Q000008:administration & dosage*; D008297:Male; D009364:Neoplasm Recurrence, Local; D012811:Sigmoid Neoplasms / Q000188:drug therapy*
D000964:Antimetabolites, Antineoplastic; D007155:Immunologic Factors; D002955:Leucovorin; D005472:Fluorouracil