title: [The effect of minimal dexamethasone on the rate of growth of mouse embryonic fibroblasts in vitro].
abstract: OBJECTIVE
  To study of the relationship between inhibition of the growth rate of mouse embryonic fibroblasts (MEF) and the dosage of dexamethasone.
  
  
  METHODS
  Cell culture.
  
  
  RESULTS
  The effect was observed from 48 to 72 hours after addition of 50 micrograms/ml (0.005%) dexamethasone. In comparison with the control, the number of MEF was cut down by 16%-26%, whereas the addition of dexamethasone between 1 microgram/ml and 10 micrograms/ml (0.0001-0.001%) had no significant effect on the rate of growth of MEF.
  
  
  CONCLUSIONS
  The minimal dosage of dexamethasone has no significant inhibitory effect on the growth rate of fibroblasts and wound healing.
authors.affiliation: Department of Ophthalmology, Zhongshan Hospital, Shanghai Medical University.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000166:cytology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D014709:Vero Cells / Q000187:drug effects
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone