title: Association of nonsteroidal anti-inflammatory drugs and aspirin with cognitive performance in middle-aged adults.
abstract: OBJECTIVE
  To assess the cross-sectional association of regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin with cognitive function in 13,153 individuals, aged 48-67 years, participating in the Atherosclerosis Risk in Communities (ARIC) Study.
  
  
  METHODS
  Regular use of NSAIDs or aspirin was analyzed in relation to the results of three cognitive tests, the Delayed Word Recall Test, the WAIS-R Digit Symbol Subtest, and the Word Fluency Test.
  
  
  RESULTS
  After adjustment for covariates previously found to be associated with cognition in this sample, we found a weak negative association between current use of aspirin and poor Word Recall [OR = 0.84 (95% confidence interval: 0.68-1.04)] and poor Word Fluency [OR = 0.85 (0.70-1.03)]. We found no association between current use of aspirin and Digit Symbol score, nor did we find current NSAID use to be significantly associated with any of the cognitive tests.
  
  
  CONCLUSIONS
  This study suggests a modest association, at best, between NSAIDs or aspirin and better cognitive function.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Peacock
authors.forename: A R
authors.initials: AR
authors.lastname: Folsom
authors.forename: D S
authors.initials: DS
authors.lastname: Knopman
authors.forename: T H
authors.initials: TH
authors.lastname: Mosley
authors.forename: D C
authors.initials: DC
authors.lastname: Goff
authors.forename: M
authors.initials: M
authors.lastname: Szklo
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014888:Wechsler Scales
chemical_list: D000893:Anti-Inflammatory Agents; D001241:Aspirin