Synthesis and biological action of 5-oxo-1,2,4-triazine derivatives.
In this study, the biological activity of the 5-oxo-1,2,4-triazine derivatives 12-17 obtained in a reaction of N3-substituted amidrazones 1-6 with dimethyl acethylenedicarboxylate (DMAD) has been examined.
Modzelewska-Banachiewicz
B
B
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Maria Curie-Sklodowska University, Lublin, Poland.
Kalabun
J
J
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects*; D015169:Colony Count, Microbial; D005658:Fungi / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D014227:Triazines