title: A chromene and prenylated benzoic acid from Piper aduncum.
abstract: In addition to nerolidol, 2',6'-dihydroxy-4'-methoxydihydrochalcone, methyl 2,2-dimethyl-8-(3'-methyl-2'-butenyl)-2H-1-chromene-6-carboxylate, methyl 2,2-dimethyl-2H-1-chromene-6-carboxylate and methyl 8-hydroxy-2,2-dimethyl-2H-1-chromene-6-carboxylate, two new natural products were isolated from the leaves of Piper aduncum, 2,2-dimethyl-2H-1-chromene-6-carboxylic acid and 3-(3',7'-dimethyl-2',6'-octadienyl)-4-methoxybenzoic acid. The structures of the isolates were established based on analysis of spectroscopic data, including ES-MS. The DNA-damaging activity of the isolated compounds was also investigated against mutant strains of Saccharomyces cerevisiae.
authors.affiliation: Instituto de Química, Universidade Estadual Paulista, Araraquara, SP, Brazil.
authors.forename: D C
authors.initials: DC
authors.lastname: Baldoqui
authors.forename: M J
authors.initials: MJ
authors.lastname: Kato
authors.forename: A J
authors.initials: AJ
authors.lastname: Cavalheiro
authors.forename: V da S
authors.initials: Vda S
authors.lastname: Bolzani
authors.forename: M C
authors.initials: MC
authors.lastname: Young
authors.forename: M
authors.initials: M
authors.lastname: Furlan
mesh_terms: D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D062425:Hydroxybenzoate Ethers; D010946:Plants, Medicinal / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development; D013057:Spectrum Analysis
chemical_list: C121079:2,2-dimethyl-2H-1-chromene-6-carboxylic acid; C121078:3-(3',7'-dimethyl-2',6'-octadienyl)-4-methoxybenzoic acid; D001565:Benzoates; D001578:Benzopyrans; D062425:Hydroxybenzoate Ethers