title: The onset of neuromuscular block at the masseter muscle as a predictor of optimal intubating conditions with rocuronium.
abstract: After an intubating dose of rocuronium satisfactory intubating conditions are achieved before the onset time at the adductor pollicis. We examined the possibility that measurement of the relaxation of the masseter muscle is a more appropriate guide when determining the intubating time. Simultaneous accelerometry with a 0.1-Hz single twitch stimulation of the chin and thumb was performed in 20 patients after 0.6 mg kg-1 rocuronium. We observed a significantly more brief mean lag time and onset time at the masseter muscle (22.5 and 61 vs. 32.5 and 160 s). The corresponding mean relaxation at the onset time was also significantly more pronounced at the masseter muscle (99.6 vs. 97.6%). A mean onset time at the masseter muscle of 61 s as produced by rocuronium corresponds clinically with excellent or good intubating conditions. From these results, we suggest that measurement of the onset time of muscle relaxation at the masseter muscle appears to be a better predictor of good intubating conditions than measurements made using the adductor pollicis muscle after administration of rocuronium.
authors.affiliation: Department of Anaesthesia, University Hospital, Gent, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: De Mey
authors.forename: L
authors.initials: L
authors.lastname: De Baerdemaeker
authors.forename: M
authors.initials: M
authors.lastname: De Laat
authors.forename: G
authors.initials: G
authors.lastname: Rolly
mesh_terms: D000293:Adolescent; D000328:Adult; D000732:Androstanols; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects*; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium; D013933:Thumb; D013997:Time Factors
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium