title: [Acute respiratory distress syndrome].
abstract: Acute respiratory distress syndrome (ARDS) is the general term used for severe acute respiratory failure of diverse aetiology. It is associated with a high morbidity, mortality (50-70%), and financial costs. Regardless of aetiology, the basic pathogenesis of ARDS is a systemic inflammatory response leading to a diffuse inflammatory process that involves both lungs, thus causing diffuse alveolar and endothelial damage with increased pulmonary capillary permeability and excessive extravascular lung water accumulation. ARDS is commonly associated with sepsis and multiple organ failure. The clinical picture involves progressive hypoxaemia, radiographic evidence of pulmonary oedema, decreased lung compliance and pulmonary hypertension. Despite the scientific and technological progress in critical care medicine, there is no specific ARDS therapy available at the moment and its management remains supportive. Therapeutic goals include resolution of underlying conditions, maintenance of acceptable gas exchange and tissue oxygenation and prevention of iatrogenic lung injury. Many new specific therapeutic strategies have been developed, however, most of them require further scientific evaluation. The paper reviews definition, basic pathogenesis and pathophysiology of ARDS and discusses current concepts of therapeutic possibilities of ARDS.
authors.affiliation: I. interní klinika LF UK a FN, Plzen.
authors.forename: M
authors.initials: M
authors.lastname: Matĕjovic
authors.forename: I
authors.initials: I
authors.lastname: Novák
authors.forename: V
authors.initials: V
authors.lastname: Srámek
authors.forename: R
authors.initials: R
authors.lastname: Rokyta
authors.forename: P
authors.initials: P
authors.lastname: Hora
authors.forename: M
authors.initials: M
authors.lastname: Nalos
mesh_terms: D006801:Humans; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
vernacular_title: Akutní respiracní distress syndrom.