title: Total Synthesis of the Marine Natural Product 7-Deoxy-okadaic Acid: A Potent Inhibitor of Serine/Threonine-Specific Protein Phosphatases.
abstract: A small change to the structure of okadaic acid (1), the omission of the single hydroxy group at C7, facilitated substantially the first total synthesis of the derivative 7-deoxyokadaic acid (2). The conformation of 2 is in agreement with that of 1 and this minimal structural variation has been reported previously to have little effect on the inhibitory activity towards the serine/threonine-specific protein phosphatases PP-1 and PP-2A.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, MN 55455 (USA).
authors.initials: AB
authors.lastname: Dounay
authors.initials: RA
authors.lastname: Urbanek
authors.initials: SF
authors.lastname: Sabes
authors.initials: CJ
authors.lastname: Forsyth