title: Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula.
abstract: BACKGROUND
  Factors other than dietary fatty acids could be involved in the variability observed in blood docosahexaenoate (22:6n-3) and arachidonate (20:4n-6) status in formula-fed infants.
  
  
  OBJECTIVE
  We considered the 22:6n-3 and 20:4n-6 status at birth to be one of these factors and studied its influence on postnatal changes in term infants fed 4 different diets.
  
  
  METHODS
  The blood phospholipid composition was determined at birth and on day 42 of feeding in 83 term infants fed breast milk, nonsupplemented formula, or 2 different 22:6n-3-supplemented formulas. Relations between 22:6n-3 and 20:4n-6 status at birth and their relative postnatal changes, calculated by the difference between status at the end of the feeding period (6 wk of age) and at birth, were assessed.
  
  
  RESULTS
  Postnatal changes in the plasma and erythrocyte phospholipids 22:6n-3 and 20:4n-6 were negatively related to their respective concentrations at birth (P < 0.01) and the slopes of the regression lines were not significantly affected by the type of milk ingested. Adjusted mean values for phospholipid 22:6n-3 in nonsupplemented-formula-fed infants and for 20:4n-6 in formula-fed infants decreased significantly more than they did in the other infant groups (P < 0.02). The status at birth and the type of milk ingested explained 33-64% and 7-47%, respectively, of the variability in postnatal changes.
  
  
  CONCLUSIONS
  The status of 22:6n-3 and 20:4n-6 at birth in term infants is one of the major determinants of postnatal changes in these fatty acids. This finding indicates that research is required to characterize environmental, genetic, or both factors, which, in addition to maternal diet, could influence fatty acid status at birth.
authors.affiliation: Equipe Associée Lipides et Croissance, Université de Tours, Tours and Institut National de la Recherche Agronomique, Jouy-en-Josas. guesnet@jouy.inra.fr
authors.forename: P
authors.initials: P
authors.lastname: Guesnet
authors.forename: P
authors.initials: P
authors.lastname: Pugo-Gunsam
authors.forename: C
authors.initials: C
authors.lastname: Maurage
authors.forename: M
authors.initials: M
authors.lastname: Pinault
authors.forename: B
authors.initials: B
authors.lastname: Giraudeau
authors.forename: J M
authors.initials: JM
authors.lastname: Alessandri
authors.forename: G
authors.initials: G
authors.lastname: Durand
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: C
authors.initials: C
authors.lastname: Couet
mesh_terms: D016718:Arachidonic Acid / Q000097:blood*; D004281:Docosahexaenoic Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D008895:Milk, Human; D010743:Phospholipids / Q000097:blood*
chemical_list: D010743:Phospholipids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid