title: Dental maturity in children of short stature--a two-year longitudinal study of growth hormone substitution.
abstract: The aim of this investigation was to present the 2-year follow-up results of a longitudinal study examining the influence of growth hormone (GH) substitution on dental maturity in healthy children of short stature (height <2 SD). At baseline, the children were divided into a GH-deficient group and a GH non-deficient group, and comparisons were made with healthy controls (height between -2 SD and 2 SD) and between the short stature groups. The GH-substituted group included 24 children (8 F, 16 M) with a mean chronological age of 12.20 +/- 2.40 years, whereas the GH non-substituted group included 19 children (5 F, 14 M) with a mean chronological age of 11.00 +/- 2.40 years. The corresponding age- and sex-matched control groups constituted 48 and 36 children, respectively. The mean dental age in the GH-substituted group was 11.60 +/- 2.70 years, compared to their healthy controls 12.40 +/- 2.60 years (P< 0.05). The dental age for the GH non-substituted children was 10.20 +/- 2.60 years compared to their controls 11.90 +/- 2.60 years (P< 0.001). GH-substituted children show an acceleration in their dental maturity in contrast to controls, whereas in non-substituted children the acceleration is less pronounced.
authors.affiliation: Department of Pediatric Dentistry, School of Dentistry, Karolinska Institutet, Stockholm, Sweden. larisa.krekmanova@ofa.ki.se
authors.forename: L
authors.initials: L
authors.lastname: Krekmanova
authors.forename: J
authors.initials: J
authors.lastname: Carlstedt-Duke
authors.forename: C
authors.initials: C
authors.lastname: Marcus
authors.forename: G
authors.initials: G
authors.lastname: Dahllöf
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D004393:Dwarfism, Pituitary / Q000503:physiopathology*; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency* / Q000494:pharmacology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009811:Odontometry; D012016:Reference Values; D015203:Reproducibility of Results; D014070:Tooth / Q000187:drug effects / Q000254:growth & development*
chemical_list: D019382:Human Growth Hormone