Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT.
The synthesis of some symmetrical phosphoramidate dimers of AZT is presented. The synthetic scheme includes the formation of the symmetrical H-phosphonate diester of AZT, followed by its conversion to several dinucleoside phosphoramidate analogues. The compounds were evaluated for their anti-retroviral activity.
Kers
I
I
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Girardet
J L
JL
Gosselin
G
G
Perigaud
C
C
Imbach
J L
JL
Stawinski
J
J
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D019281:Dimerization; D006801:Humans; D009943:Organophosphorus Compounds / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D019380:Anti-HIV Agents; D009943:Organophosphorus Compounds; D015215:Zidovudine