[Gastric carcinoid--pathogenesis and treatment].
Gastric carcinoid tumours are rare neoplasms of neuroendocrine origin. They are believed to grow from enterochrommaffin-like (ECL) cells. Three different types of tumours can be distinguished: type I: hypergastrinaemic, induced by achlorhydria in chronic atrophic gastritis; type II: hypergastrinaemic, associated with Zollinger-Ellison syndrome and multiple endocrine neoplasia syndrome type 1; type III: sporadic. The trophic effect of gastrin on ECL cells is of crucial importance in the pathogenesis and treatment of hypergastrinaemic carcinoids. In these patients, hypergastrinaemia leads to ECL-hyperplasia, -dysplasia and -neoplasia. Hypergastrinaemic carcinoids often follow a very benign course, which makes it possible to avoid surgery, at least in patients at high surgical risk. The management of these three types is discussed.
Bründler
R
R
Pathologisches Institut, Kantonsspital Luzern.
Gebbers
J O
JO
Criblez
D
D
D002276:Carcinoid Tumor / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000503:physiopathology / Q000628:therapy; D013274:Stomach Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology / Q000628:therapy
Das Magenkarzinoid--Pathogenese und Therapie.