Novel hydrogel system from scleroglucan: synthesis and characterization.
New hydrogels obtained by a crosslinking reaction between the polycarboxylated derivative of scleroglucan (sclerox) and 1, 6-hexanedibromide have been prepared and characterized. Different ratios between the alkane dihalide and sclerox yielded products with appreciably different properties. Water uptake by the hydrogel with a low degree of crosslinking was remarkably affected by ionic strength. The diffusion of a model molecule (theophylline) through the swelled crosslinked polymers was studied and the theoretical analysis leading to the calculation of permeability coefficients in different environmental conditions is reported. Tablets prepared with one of the new hydrogels behaved as swellable monolithic systems suitable for sustained drug release.
Coviello
T
T
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università 'La Sapienza', P.le A.Moro 5, 00185, Rome, Italy.
Grassi
M
M
Rambone
G
G
Santucci
E
E
Carafa
M
M
Murtas
E
E
Riccieri
F M
FM
Alhaique
F
F
D001965:Bromides / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D004058:Diffusion; D005936:Glucans / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009994:Osmolar Concentration; D010539:Permeability; D013223:Statistics as Topic; D013607:Tablets; D013806:Theophylline / Q000493:pharmacokinetics*; D014665:Vasodilator Agents / Q000493:pharmacokinetics
D001965:Bromides; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D005936:Glucans; D020100:Hydrogels; D013607:Tablets; D014665:Vasodilator Agents; C045938:scleroglucan; D013806:Theophylline