Differential expression patterns of inositol trisphosphate receptor types 1 and 3 in the rat suprachiasmatic nucleus.
Inositol 1,4,5-trisphosphate receptor types 1 (IP(3)-R1) and 3 (IP(3)-R3) were found in the rat suprachiasmatic nucleus (SCN) and the levels of both of IP(3)-R1 and IP(3)-R3 mRNA showed a reciprocal circadian rhythm. IP(3)-R1 immunoreactive cells were localized in neuronal cells in the SCN. In contrast, IP(3)-R3 immunoreactive cells were mainly localized in the astrocytes in the ventrolateral region of the SCN. These results suggest that IP(3)-R1 and IP(3)-R3 may have differential roles in the SCN in the mammalian circadian rhythm.
Hamada
T
T
Ishida Group of Clock Gene, National Institute of Bioscience and Human Technology, AIST, MITI, 1-1 Higashi, Tsukuba Science City 305-8566, Japan.
Niki
T
T
Ziging
P
P
Sugiyama
T
T
Watanabe
S
S
Mikoshiba
K
K
Ishida
N
N
D000818:Animals; D000918:Antibody Specificity; D001931:Brain Mapping; D015220:Calcium Channels; D002940:Circadian Rhythm / Q000502:physiology*; D007150:Immunohistochemistry; D015544:Inositol 1,4,5-Trisphosphate; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012260:Ribonucleases; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D012260:Ribonucleases