[The effect of anticonvulsants on the nitric oxide content and level of lipid peroxidation in the brain of rats in model seizure states].
EPR spectroscopy was performed to study the effect of anticonvulsants lamotrigine and phenobarbital on nitric oxide generation in rat brain on models of a convulsive seizure caused by exposure to maximal electric shock or corasole injection. The intensity of lipid peroxidation (LPO) was studied at the same time. The anticonvulsants under study proved to be capable of suppressing to a various degree intensification of nitric oxide generation and increase of LPO intensity in the rat cerebral cortex induced by convulsions. This widens the existing idea of the mechanism of the effect of antiepileptic agents.
Bashkatova
V G
VG
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Vitskova
G Iu
GIu
Narkevich
V B
VB
Mikoian
V D
VD
Vanin
A F
AF
Raevskiĭ
K S
KS
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003292:Convulsants; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy; D004597:Electroshock; D000077213:Lamotrigine; D015227:Lipid Peroxidation / Q000187:drug effects*; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism*; D010433:Pentylenetetrazole; D010634:Phenobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
D000927:Anticonvulsants; D003292:Convulsants; D014227:Triazines; D009569:Nitric Oxide; D000077213:Lamotrigine; D010433:Pentylenetetrazole; D010634:Phenobarbital
Vliianie antikonvul'santov na soderzhanie oksida azota i uroven' perekisnogo okisleniia lipidov v mozge krys pri model'nykh sudorozhnykh sostoianiiakh.