title: Mid-term results of conventional bypass surgery for complex proximal left anterior descending coronary artery stenoses.
abstract: BACKGROUND
  The significant involvement of proximal left anterior descending (LAD) coronary artery affects patient prognosis and must be treated. Recently, as alternative methods to conventional coronary bypass (CABG), minimally invasive direct coronary artery bypass grafting (MIDCAB) and percutaneous transluminal coronary angioplasty with stent implantation (PTCA/S) have been proposed to reduce costs and patient discomfort. The aim of this study was to obtain early and medium-term results of CABG in patients with complex LAD disease in whom the expected results with PTCA/S or MIDCAB would have been suboptimal.
  
  
  METHODS
  We retrospectively examined one hundred consecutive patients subjected to isolated CABG who received either a single graft to LAD or several grafts to LAD and diagonal branches. The choice of CABG was due to poor expectable results with PTCA/S or MIDCAB because of anatomical characteristics of the lesion, inclusion in ongoing randomized study comparing surgical versus non-surgical revascularization, or preference on the part of the cardiologist or patient.
  
  
  RESULTS
  Left internal mammary artery (LIMA) was grafted to LAD in 99 (99%) patients; 65 (65%) patients received at least one saphenous graft to the diagonal branches. No death was observed within 30 days from the operation. One (1%) patient had a perioperative non-Q myocardial infarction (MI). At a mean follow-up time of 38 +/- 16 months (range 2-60), there were no cardiac deaths and no new MI. Six patients complained of recurrent angina: in all cases but one (vein graft failure to a diagonal branch), there were no clinical or diagnostic signs suggesting other graft failures. The probability of freedom from early and late events, including cardiac death, MI and recurrence of angina regardless of site, was 99% at 1 year and 86% at 5 years.
  
  
  CONCLUSIONS
  At present, conventional CABG seems to be the "gold standard palliation" of LAD disease in most cases. It can be performed safely with excellent early and medium-term results in terms of freedom from cardiac events. Its comparison with percutaneous transluminal techniques and MIDCAB needs to be addressed in further prospective studies.
authors.affiliation: Department of Cardiac Surgery, Tor Vergata University European Hospital, Rome.
authors.forename: S
authors.initials: S
authors.lastname: Forlani
authors.forename: C
authors.initials: C
authors.lastname: Bassano
authors.forename: F
authors.initials: F
authors.lastname: Tomai
authors.forename: R
authors.initials: R
authors.lastname: De Paulis
authors.forename: A
authors.initials: A
authors.lastname: Penta de Peppo
authors.forename: L
authors.initials: L
authors.lastname: Colagrande
authors.forename: M M
authors.initials: MM
authors.lastname: Buratta
authors.forename: L W
authors.initials: LW
authors.lastname: Chen
authors.forename: M L
authors.initials: ML
authors.lastname: Matteucci
authors.forename: L
authors.initials: L
authors.lastname: Chiariello
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome