title: Consistency of isochromosome 7q and trisomy 8 in hepatosplenic gammadelta T-cell lymphoma: detection by fluorescence In situ hybridization of a splenic touch-preparation from a pediatric patient.
abstract: Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.
authors.affiliation: Department of Pathology, St. Christopher's Hospital for Children, Erie Avenue at Front Street, Philadelphia, PA 19134, USA.
authors.forename: S
authors.initials: S
authors.lastname: Coventry
authors.forename: H H
authors.initials: HH
authors.lastname: Punnett
authors.forename: E Z
authors.initials: EZ
authors.lastname: Tomczak
authors.forename: D
authors.initials: D
authors.lastname: Casher
authors.forename: M
authors.initials: M
authors.lastname: Koehler
authors.forename: M J
authors.initials: MJ
authors.lastname: Borowitz
authors.forename: C A
authors.initials: CA
authors.lastname: Griffin
authors.forename: J P
authors.initials: JP
authors.lastname: de Chadarévian
mesh_terms: D002648:Child; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D013160:Splenic Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy / Q000235:genetics*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta