title: Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support.
abstract: A general method was developed to generate six-membered cyclic thiazinanes on solid support. Three diversity sites were introduced into this scaffold using primary amines, aldehydes, and 2-bromoalkanoic acids. The methodology to prepare individual cyclic thiazinanes as well as combinatorial libraries of these compounds is described.
authors.affiliation: Affymax Research Institute, Santa Clara, CA 95051, USA. reza_mortezaei@affymax.com
authors.forename: R
authors.initials: R
authors.lastname: Mortezaei
authors.forename: S
authors.initials: S
authors.lastname: Ida
authors.forename: D A
authors.initials: DA
authors.lastname: Campbell
mesh_terms: D000478:Alkylation; D016208:Databases, Factual; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D013843:Thiazines