Recovery after anaesthesia for pulmonary surgery: desflurane, sevoflurane and isoflurane.
We have studied maintenance and recovery profiles after general anaesthesia with sevoflurane, desflurane and isoflurane in 100 patients undergoing pulmonary surgery. End-tidal concentrations of anaesthetic required to maintain mean arterial pressure and heart rate within 20% of baseline values were 1.4 +/- 0.6% for sevoflurane, 3.4 +/- 0.9% for desflurane and 0.7 +/- 0.3% for isoflurane. The three anaesthetics had comparable haemodynamic effects and arterial oxygenation during one-lung ventilation. Emergence was twice as fast with desflurane than with sevoflurane or isoflurane (mean times to extubation: 8.9 (SD 5.0) min, 18.0 (17.0) min and 16.2 (11.0) min for desflurane, sevoflurane and isoflurane, respectively). Early recovery (Aldrete score, cognitive and psychomotor functions) was also more rapid after desflurane. In pulmonary surgery, desflurane, but not sevoflurane, allowed more rapid emergence and earlier recovery than isoflurane.
Dupont
J
J
Département d'Anesthésie Réanimation Chirurgicale II, CHRU, Lille, France.
Tavernier
B
B
Ghosez
Y
Y
Durinck
L
L
Thevenot
A
A
Moktadir-Chalons
N
N
Ruyffelaere-Moises
L
L
Declerck
N
N
Scherpereel
P
P
D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D000077335:Desflurane; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000494:pharmacology; D008168:Lung / Q000601:surgery*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D010100:Oxygen