Bisalbuminuria in an adult with bisalbuminemia and nephrotic syndrome.
Bisalbuminemia (or alloalbuminemia) is a relatively rare hereditary or acquired condition characterized by the presence of two distinct albumin bands, or, less commonly, a single widened albumin band, after agarose gel electrophoresis of serum. Bisalbumins are caused by point- or chain-mutations that occur with a population frequency of 1:10,000 to 1:1000. Although no adverse clinical effects have been attributed to bisalbumins, some albumin variants have altered affinity for steroid hormones, thyroxine, or drugs. We report a case of bisalbuminuria in a 25-year-old man with bisalbuminemia and nephrotic syndrome.
Hoang
M P
MP
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9073, USA.
Baskin
L B
LB
Wians
F H
FH
D000328:Adult; D000418:Albumins / Q000032:analysis*; D000419:Albuminuria / Q000150:complications*; D004587:Electrophoresis, Agar Gel; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*; D012709:Serum Albumin / Q000032:analysis*
D000418:Albumins; D012709:Serum Albumin; C030764:bisalbumins