Circadian changes in pharmacokinetics of cyclosporin in healthy volunteers.
Circadian changes in the pharmacokinetics of cyclosporin were evaluated after oral administration of the drug, 300 mg, at 09:00 and 20:00 to twelve healthy male subjects. At 09:00, the blood concentrations of cyclosporin were higher, the area under the blood concentration-time curve from time 0 to time infinity was significantly greater (9.70 versus 8.42 microg x hr/ml), and the renal clearance was significantly slower (1.14 versus 1.48 ml/min) than those at 22:00. The terminal half-life, peak concentration, and time to reach peak concentration were not significantly different between two groups.
Choi
J S
JS
College of Pharmacy, Chosun University, Susuk-Dong, Dong-Gu, Kwangju, South Korea.
Park
H J
HJ
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D002940:Circadian Rhythm; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D016572:Cyclosporine