Clinical outcome in localized renal cell carcinomas related to immunoexpression of proliferating cell nuclear antigen, Ki-67 antigen, and tumor size.
This study was designed to clarify the relationship between clinical outcome and immunoexpression of proliferating cell nuclear antigen (PCNA) and Ki-67 antigen (Ki-67) in 71 localized renal cell carcinomas (RCCs) of Robson stage I and II, related to the disease recurrence and tumor size. PCNA and Ki-67 expressions showed significant differences between non-recurring and recurring groups and more variability in stage II than in stage I. Recurrence rates according to tumor size were 0% for </=2.5 cm, 4% for 2.5 to 5.0 cm, and 55.8% for >/=5.0 cm. It was concluded that PCNA and Ki-67 expression profiles were considered to be closely related to tumor stage and showed some promise for predicting the disease recurrence.
Onda
H
H
Department of Urology, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Yasuda
M
M
Serizawa
A
A
Osamura
R Y
RY
Kawamura
N
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen
D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen