[The effect of klofelin on the activity of the sensory neurons of the trigeminal complex induced by stimulation of the superior sagittal sinus].
In doses of 0.25 and 0.5 mg/kg clophelin inhibited the responses of the trigeminal complex sensory neurons to electrical stimulation of the superior sagittal sinus in conscious immobilized rats. Naloxon (0.1 mg/kg) and yohimbine (1 mg/kg) weakened whereas prazosin (1 mg/kg) did not affect the inhibiting effect of clophelin.
Ivanov
V E
VE
Institute of Pharmacology, St. Petersburg Medical University, Russia.
Amelin
A V
AV
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003392:Cranial Sinuses / Q000502:physiology*; D004347:Drug Interactions; D004558:Electric Stimulation; D008297:Male; D008839:Microelectrodes; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009475:Neurons, Afferent / Q000187:drug effects* / Q000502:physiology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D018709:Statistics, Nonparametric; D014278:Trigeminal Nuclei / Q000187:drug effects* / Q000502:physiology; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D000700:Analgesics; D009292:Narcotic Antagonists; D015016:Yohimbine; D009270:Naloxone; D003000:Clonidine; D011224:Prazosin
Vliianie klofelina na vyzvannuiu stimuliatsieĭ verkhnego sagittal'nogo sinusa aktivnost' sensornykh neĭronov troĭnichnogo kompleksa.