title: Use of mass vaccination with a reduced dose of REV 1 vaccine for Brucella melitensis control in a population of small ruminants.
abstract: Mass vaccination with reduced dose 1/50 Rev 1 strain live vaccine (1-2 10(9) colony forming units), administered subcutaneously, over a four and a half year period reduced the prevalence of Brucella melitensis in Kuwait's small ruminant population from 5.8% in 1993 to 2.02% in 1997. Serological test results using the Rose Bengal Plate Test, Rivanol Agglutination Test and Complement Fixation showed no evidence of persistence of positive serology in animals nine or more months after vaccination. Questionnaires and post-vaccination flock inspections found that the effects on gestation (abortions) were minimal--and not proven to be due to the vaccine. The conclusion from these findings is that mass vaccination with reduced dose Rev 1 administered by the subcutaneous route is a practical field strategy for control of Brucella melitensis.
authors.affiliation: GRM International Pty Ltd, Brisbane, Queensland, Australia.
authors.forename: D W
authors.initials: DW
authors.lastname: Scharp
authors.forename: S A
authors.initials: SA
authors.lastname: al Khalaf
authors.forename: M W
authors.initials: MW
authors.lastname: al Muhanna
authors.forename: R A
authors.initials: RA
authors.lastname: Cheema
authors.forename: W
authors.initials: W
authors.lastname: Godana
mesh_terms: D000034:Abortion, Veterinary / Q000453:epidemiology; D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000737:chemistry; D002004:Brucella Vaccine / Q000008:administration & dosage; D017347:Brucella melitensis / Q000276:immunology*; D002006:Brucellosis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D003168:Complement Fixation Tests / Q000662:veterinary; D004975:Ethacridine / Q000737:chemistry; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry; D015511:Goat Diseases / Q000453:epidemiology / Q000517:prevention & control*; D006041:Goats; D007279:Injections, Subcutaneous / Q000662:veterinary; D007730:Kuwait / Q000453:epidemiology; D011247:Pregnancy; D012395:Rose Bengal / Q000737:chemistry; D016036:Seroepidemiologic Studies; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000517:prevention & control*; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000891:Anti-Infective Agents, Local; D002004:Brucella Vaccine; D005456:Fluorescent Dyes; D014613:Vaccines, Attenuated; D012395:Rose Bengal; D004975:Ethacridine