Molecular basis of drug recognition by specific T-cell receptors.
In recent years the involvement of T cells in allergic reactions to drugs has been well established. However, several molecular aspects of drug recognition by specific T cells remain still unclear. This review will discuss the known pathways of drug presentations by antigen presenting cells, the recognition of MHC/peptide/drug complexes by specific T-cell receptors, and the activation mechanism of drug-specific T cells.
von Greyerz
S
S
Institute of Immunology and Allergy, Inselspital, Bern, Switzerland.
Burkhart
C
C
Pichler
W J
WJ
D000485:Allergens / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens; D011948:Receptors, Antigen, T-Cell