title: Selective suppression of cerebellar GABAergic transmission by an autoantibody to glutamic acid decarboxylase.
abstract: Humoral immune response to glutamic acid decarboxylase (GAD) has been implicated in the pathogenesis of stiff-man syndrome and cerebellar ataxia, but the underlying pathomechanism is unclear. Using a whole-cell patch-clamp technique with rat cerebellar slices, we found that immunoglobulins present in the cerebrospinal fluid of an ataxic patient acted presynaptically to cause a selective suppression of GABAergic transmission. This synaptic depression was most likely elicited by an autoantibody to GAD.
authors.affiliation: Department of Neurology, School of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishida
authors.forename: H
authors.initials: H
authors.lastname: Mitoma
authors.forename: S Y
authors.initials: SY
authors.lastname: Song
authors.forename: T
authors.initials: T
authors.lastname: Uchihara
authors.forename: A
authors.initials: A
authors.lastname: Inaba
authors.forename: S
authors.initials: S
authors.lastname: Eguchi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D002524:Cerebellar Ataxia / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D004594:Electrophysiology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase