title: Multi-step evolution of lung cancer.
abstract: In an attempt to improve the poor survival rates for lung cancer, therapeutic strategies require a deeper understanding of the biological events contributing to the formation and progression of the disease. In particular, the importance of studying the different stages of lung cancer including early pre-neoplasia is being recognised and studies examining genetic changes in pre-invasive and invasive lesions are being used to identify key events in tumorigenesis.
authors.affiliation: MRC Molecular Oncology Group, Department of Oncology, MRC Centre, University of Cambridge, Hills Road, CB2 2QH, UK.
authors.forename: K L
authors.initials: KL
authors.lastname: Braithwaite
authors.forename: P H
authors.initials: PH
authors.lastname: Rabbitts
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001980:Bronchi / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor