title: A kinetic model for Ascaridia galli populations in chickens treated with mixed salts of copper and zinc.
abstract: The action of mixed salts of copper and zinc (basic and neutral) on Hisex chickens experimentally infected with Ascaridia galli has been studied. The data show that the lowest host mortality and decrease in body weight gain and the highest reduction in nematode loading occurs in infected chickens treated with basic salts (in comparison with infected chickens, untreated or treated with neutral salts). A mathematical model has been proposed to provide a quantitative interpretation of the observed results. The model solutions of the kinetics of parasite numbers and of the gain in body weight are in a good agreement with the experimental data. One of the kinetic parameters in the model is defined as a phenomenological constant of the host immune response. Its value is determined in the case of infected and untreated chickens.
authors.affiliation: Institute of Experimental Pathology and Parasitology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Gabrashanska
authors.forename: S
authors.initials: S
authors.lastname: Teodorova
authors.forename: M
authors.initials: M
authors.lastname: Galvez-Morros
authors.forename: O
authors.initials: O
authors.lastname: Garcia Martinez
mesh_terms: D000818:Animals; D001197:Ascaridia / Q000502:physiology; D001198:Ascaridiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D001835:Body Weight; D002645:Chickens / Q000469:parasitology*; D003300:Copper / Q000627:therapeutic use*; D006790:Host-Parasite Interactions; D008297:Male; D008954:Models, Biological; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D015996:Survival Rate; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D003300:Copper; D015032:Zinc