title: Synthetic studies on 2'-substituted-4'-thiocytidine derivatives as antineoplastic agents.
abstract: As potential antineoplastic agents, we have synthesized 4'-thioFAC and 4'-thiocytarazid by developing an alternative synthetic method. 4'-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.
authors.affiliation: Biochemicals Division, Yamasa Corporation, Chiba, Japan. chem2yms@choshinet.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Kitano
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Machida
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003562:Cytidine / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D013872:Thionucleosides / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013872:Thionucleosides; D003562:Cytidine