Risperidone treatment of behavioral disturbances in outpatients with dementia.
The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 +/- 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extrapyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.
Irizarry
M C
MC
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Ghaemi
S N
SN
Lee-Cherry
E R
ER
Gomez-Isla
T
T
Binetti
G
G
Hyman
B T
BT
Growdon
J H
JH
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000523:psychology*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001480:Basal Ganglia Diseases / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology*; D012189:Retrospective Studies; D018967:Risperidone / Q000009:adverse effects*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D018967:Risperidone