title: [Standard and hyperfractionated irradiation for locally advanced tumors (T3NOMO) of the larynx].
abstract: Two modalities of radiotherapy of locally advanced tumors (T3N0M0) of the larynx were compared in the treatment of 89 patients. Forty-six patients of group I received 2 Gy daily, 5 times a week (COD 65-70 Gy), while 43 patients of group 11--1.1 Gy of multifractionated radiation twice a day, at 4-hr interval (COD 70-75 Gy). Five-year survival in group 1 was 67.1--11%, recurrence-free rate--54 +/- 7.3%, while in group 11--76 +/- 6.5 and 67 +/- 7.1%, respectively, (p < 0.4).
authors.affiliation: N.N.Blokhin Center for Cancer Research, Russian Medical Academy, Moscow.
authors.forename: S I
authors.initials: SI
authors.lastname: Tkachev
authors.forename: S B
authors.initials: SB
authors.lastname: Alieva
authors.forename: V S
authors.initials: VS
authors.lastname: Alferov
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D016019:Survival Analysis; D016896:Treatment Outcome
vernacular_title: Standartnoe i giperfraktsionirovannoe obluchenie pri mestnorasprostranennom rake gortani (T3NOMO)