Antiallergic agent from natural sources. 2. Structures and leukotriene release-inhibitory effect of torososide B and torosachrysone 8-O-6"-malonyl beta-gentiobioside from Cassia torosa Cav.
Two new anti-allergic compounds, torososide B and torosachrysone 8-O-6"-malonyl gentiobioside were isolated from the seeds of Cassia torosa Cav., and their structures were established as physcion 8-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl- (1-->3)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside and torosachrysone 8-O-beta-D-glucopyranosyl-(1-->6)-6-malonyl beta-D-glucopyranoside on the basis of spectral and chemical evidence. Torososide B and torosachrysone 8-O-6"-malonyl gentiobioside were found to inhibit the release of leucotrienes from rat peritoneal mast cells induced by calcium ionophore A 23187.
Kanno
M
M
College of Pharmacy, Nihon University, Chiba, Japan.
Shibano
T
T
Takido
M
M
Kitanaka
S
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002366:Cassia / Q000737:chemistry*; D003864:Depression, Chemical; D004187:Disaccharides / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D020024:Leukotriene Antagonists / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015289:Leukotrienes / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry* / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D018926:Anti-Allergic Agents; D004187:Disaccharides; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D009844:Oligosaccharides; C122037:torosachrysone 8-O-6''-malonyl gentiobioside; C122124:torososide B