title: [An experimental study on effect of atrial natriuretic peptide on intraocular pressure of white rabbits].
abstract: OBJECTIVE
  To study the therapeutic effect of atrial natriuretic peptide (ANP) on glaucoma.
  
  
  METHODS
  Various doses of ANP were injected subconjunctivally in albino rabbits, and their effects on intraocular pressures (IOPs) were observed.
  
  
  RESULTS
  The IOPs were significantly decreased by the subconjunctival injection of 20, 30, 40 micrograms of ANP, and with a dose of 40 micrograms, the maximum effect of IOP lowering of 0.88-0.15 kPa maintaining for the longest time 7.5 hours was obtained. Generally, one hour after the injection, the maximum effect could be seen. A dose-effect relationship that is the degree of the reduction of IOP increasing with the dose increase of ANP could be observed.
  
  
  CONCLUSIONS
  This study indicates that ANP might play an effective therapeutic role in glaucoma.
authors.affiliation: Ophthalmology Department, 210 PLA Hospital, Dalian.
authors.forename: L
authors.initials: L
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Guan
authors.forename: S
authors.initials: S
authors.lastname: Gao
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits
chemical_list: D009320:Atrial Natriuretic Factor