Effects of losartan and captopril on QT dispersion in elderly patients with heart failure. ELITE study group.
Differences in QT dispersion (a predictor for sudden death) were observed in a subgroup of patients in the ELITE heart failure study of losartan compared with captopril, and may explain improved survival with losartan.
Brooksby
P
P
Robinson
P J
PJ
Segal
R
R
Klinger
G
G
Pitt
B
B
Cowley
A J
AJ
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D002316:Cardiotonic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology / Q000517:prevention & control; D004562:Electrocardiography / Q000187:drug effects*; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008133:Long QT Syndrome / Q000188:drug therapy* / Q000401:mortality; D019808:Losartan / Q000009:adverse effects / Q000627:therapeutic use*; D015996:Survival Rate; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents; D002216:Captopril; D019808:Losartan