title: [Central neurologic manifestations of Crohn disease].
abstract: BACKGROUND
  Neurological involvement in Crohn's disease is unusual.
  
  
  METHODS
  We report two cases of Crohn's disease. Central nervous system deficit was observed in the first patient, while psychiatric disorders were present in the second patient. In both cases, MRI confirmed the presence of a T2 hypersignal in the white matter.
  
  
  CONCLUSIONS
  Central neurological disorders could either be part of extra-intestinal symptoms in Crohn's disease or precede diagnosis. However, their frequency is not well known or documented. The association of Crohn's disease with multiple sclerosis may obscure the diagnosis. Cerebrovascular accident, seizures, headaches, focal neurological deficits, or sometimes severe psychiatric disorders are encountered. Numerous pathophysiological hypotheses have been advocated. The high frequency of abnormalities that have been observed during systematic MRI provide confirmation of the hypothesis of neurological disorders occurring during Crohn's disease.
authors.affiliation: Service de médecine interne et des maladies infectieuses, hôpital Robert-Debré, Reims, France.
authors.forename: R
authors.initials: R
authors.lastname: Jaussaud
authors.forename: J F
authors.initials: JF
authors.lastname: Deville
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D001921:Brain / Q000473:pathology; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D003866:Depressive Disorder / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000209:etiology; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones
vernacular_title: Les manifestations neurologiques centrales de la maladie de Crohn.