Phase behavioral effects on particle formation processes using supercritical fluids.
The application of supercritical fluid (SF) processing in pharmaceutical research is increasing particularly in the field of particle formation for drug delivery systems. The SF processes have benefits over the existing particle formation methods in terms of improved control, flexibility and operational ease. This review highlights the fundamental concepts of fluid phase behaviour and their influence on the various processes involving particle formation with supercritical fluids. Several phase behaviour systems are discussed to provide an insight into the factors influencing the process paths and their effects on the characteristics of the particles.
Palakodaty
S
S
Bradford Particle Design Limited, UK. s.palakodaty@bradford.ac.uk
York
P
P
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003460:Crystallization; D016503:Drug Delivery Systems; D010316:Particle Size; D012996:Solutions / Q000737:chemistry*
D012996:Solutions