Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase.
We describe the synthesis and enzymatic activity of a library of beta-carboxamido phosphonates as inhibitors of imidazole glycerol phosphate dehydratase (IGPD). Biological results suggest the presence of an enzymatic interaction site not previously observed for other inhibitors of IGPD.
Schweitzer
B A
BA
Monsanto Company, St. Louis, MO 63167, USA.
Loida
P J
PJ
Thompson-Mize
R L
RL
CaJacob
C A
CA
Hegde
S G
SG
D003198:Computer Simulation; D003454:Cryptococcus / Q000201:enzymology; D016208:Databases, Factual; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D006836:Hydro-Lyases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D010642:Phenoxyacetates / Q000138:chemical synthesis* / Q000494:pharmacology*; D012984:Software; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D010642:Phenoxyacetates; D006836:Hydro-Lyases; C021434:imidazoleglycerolphosphate dehydratase