Remarkably enhanced inhibitory effects of hybrid liposomes on the growth of specific tumor cells.
The highly specific inhibitory effects of the hybrid liposomes composed of 90 mol% L-alpha-dimyristoylphosphatidylglycerol and 10 mol% polyoxyethylene (10) dodecyl ether on the growth of lung adenocarcinoma and stomach tumor cells in vitro were obtained for the first time.
Matsumoto
Y
Y
Graduate Course of Applied Chemistry, Kumamoto Institute of Technology, Ikeda, Japan.
Kato
T
T
Iseki
S
S
Suzuki
H
H
Nakano
K
K
Iwahara
M
M
Ueoka
R
R
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002277:Carcinoma / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D002455:Cell Division / Q000187:drug effects; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008081:Liposomes / Q000737:chemistry* / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008823:Micelles; D009226:Myristates / Q000737:chemistry; D010715:Phosphatidylglycerols / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013274:Stomach Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
C117241:1,2-dimyristoyl-3-trimethylammonium propane; D000970:Antineoplastic Agents; D008081:Liposomes; D008823:Micelles; D009226:Myristates; D010715:Phosphatidylglycerols; D000644:Quaternary Ammonium Compounds; D011092:Polyethylene Glycols; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine