title: Multiple familial keratoacanthoma of Witten and Zak - A report of three siblings.
abstract: Three out of 11 siblings of a nonconsanguineous marriage suffering from biopsy-proven multiple small eruptive keratoacanthoma (KA) of Grzybowski as well as large nodular KA of Ferguson-Smith are reported. The response to oral methotrexate was not encouraging. Intravenous 5-fluorouracil (5-FU) at a dose of 12 mg/kg/day in isotonic saline given in weekly 5-day cycles resulted in almost complete resolution of small eruptive lesions and signs of involution in older large agglomerate noduloulcerative KA after 6 cycles. Thus, intravenous 5-FU was found to be an effective therapeutic modality for the Witten and Zak type of KA.
authors.affiliation: Department of Dermatology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Agarwal
authors.forename: R
authors.initials: R
authors.lastname: Chander
authors.forename: S
authors.initials: S
authors.lastname: Karmakar
authors.forename: R
authors.initials: R
authors.lastname: Walia
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002648:Child; D005192:Family Health; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007636:Keratoacanthoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male; D012867:Skin / Q000187:drug effects / Q000473:pathology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil