title: Autoimmunity in Waldenström's macroglobulinaemia.
abstract: Fifty-seven consecutive patients with Waldenström's Macroglobuliemia were studied retrospectively for autoimmune manifestations. 28 patients or 51% (16 women and 13 men) had clinical and/or serological autoimmune manifestations, two or more of these being concomitant in 20 (12 women and 8 men). The predominant findings were Coombs' positive autoimmune hemolytic anemia (16%), seropositive rheumatoid arthritis (16%), inflammatory gastric ulcer with parietal cell autoantibodies (12%), and IgM-cardiolipin syndrome (11%). 40% of the autoimmune manifestations were present at the time of diagnosis of the Waldenström's Macroglobulinaemia and 60% were observed over a mean period of 4.7 years. All patients had an IgM M-component. There was no correlation between autoimmunity and the size of the M-component or the degree of hypo-IgG and hypo-IgA gammaglobulinemia. The only correlation between autoimmunity and infection was found in patients with gastric ulcer and parietal cell autoantibodies, in whom the infection was caused by Helicobacter pylori.
authors.affiliation: Department of Hematology, Rigshospital, University of Copenhagen, Denmark.
authors.forename: V
authors.initials: V
authors.lastname: Jønsson
authors.forename: A
authors.initials: A
authors.lastname: Kierkegaard
authors.forename: S
authors.initials: S
authors.lastname: Salling
authors.forename: S
authors.initials: S
authors.lastname: Molander
authors.forename: L P
authors.initials: LP
authors.lastname: Andersen
authors.forename: M
authors.initials: M
authors.lastname: Christiansen
authors.forename: A
authors.initials: A
authors.lastname: Wiik
mesh_terms: D000368:Aged; D015551:Autoimmunity; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D012189:Retrospective Studies; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
chemical_list: D007136:Immunoglobulins