title: [Effect of variation of the dietary fat content in rats during gestation on the fatty acid profile in maternal and fetal plasma].
abstract: With the aim of knowing how changes in the fatty acid composition of the diet affect the fatty acid profile in the plasma during gestation, and the repercussions on the fetuses, in the present study we have administered semi-synthetic diets containing palm oil, olive oil, sunflower seed oil, or fish oils as the sole non-vitamin fat component to pregnant rats. The animals were studied on day 20 of the gestation and after being fed the corresponding diet. As was expected, in the palm oil diet the most abundant fatty acids were saturated, in the olive oil diet is was oleic acid, in the sunflower seed and fish oil diets while the linoleic acid was considerably higher in the sunflower seed oil diet is was linoleic acid, and the fish oil diet it was the only one to show appreciable amounts of eicosepentaenoic and docosehexacnoic acids. In turn, none of the diets contained arachidonic acid. In the plasma of the mothers the proportion of saturated fatty acids was similar in all the groups, the oleic acid was higher in the palm and olive oil diets than in the sunflower seed oil diet. In turn, although a certain proportion of arachidonic acid was found in all the groups, its proportion was lowest in the group of rats with the fish oil diet and these same fish oil rats showed a higher proportion of eicosepentaenoic and docosehexaenoic acids than the other groups did. The profile of the saturated and monounsaturated fatty acids in the plasma of the fetuses differed from that of the mothers, and the changes in the rest of the fatty acids studied were similar to those of the mother with there being a linear and significant correlation of the polyunsaturated acids values between the maternal and the fetal plasma. The fetuses of rats fed with the first dietshowed and intense deficiency of arachidonic acid, and this could have negative consequences for the post-natal development.
authors.affiliation: Facultad de Ciencias Experimentales y Técnicas, Universidad San Pablo-CEU, Madrid, España.
authors.forename: E
authors.initials: E
authors.lastname: Amusquivar
authors.forename: E
authors.initials: E
authors.lastname: Herrera
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids
vernacular_title: Efecto de variaciones en el contenido graso de la dieta de la rata durante la gestación sobre el perfil de ácidos grasos en plasma materno y fetal.