title: Synthesis and biological application of a new heterodinucleotide with both anti-HSV and anti-HIV activity.
abstract: A new antiviral drug with both anti-HSV and anti-HIV activity was synthesized by coupling Acyclovir and the acyclic nucleoside phosphonate (R)PMPA. The heterodinucleotide ACVpPMPA encapsulated into autologous erythrocytes was added to human macrophages providing an effective in vitro protection from HSV-1 and HIV-1 replication.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Franchetti
authors.forename: G
authors.initials: G
authors.lastname: Abu Sheikha
authors.forename: L
authors.initials: L
authors.lastname: Cappellacci
authors.forename: M
authors.initials: M
authors.lastname: Grifantini
authors.forename: E
authors.initials: E
authors.lastname: Balestra
authors.forename: C F
authors.initials: CF
authors.lastname: Perno
authors.forename: G
authors.initials: G
authors.lastname: Brandi
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: M
authors.initials: M
authors.lastname: Magnani
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000821:virology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C120723:ACVpPMPA; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D009705:Nucleosides