The role of endothelin-1 in asthma.
This review seeks to examine the potential contribution of the recently discovered peptide endothelin-1 to the pathophysiology of asthma. The actions of endothelin-1 which mimic features of asthma, the evidence for increased production of endothelin-1 in asthma and the potential for asthma therapy based on modification of the activity of endothelin-1 are reviewed.
Chalmers
G W
GW
Dept of Respiratory Medicine, Western Infirmary, Glasgow, UK.
Thomson
N C
NC
D000402:Airway Obstruction / Q000503:physiopathology; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D009092:Mucous Membrane / Q000378:metabolism
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1