title: Cancer incidence among European man-made vitreous fiber production workers.
abstract: OBJECTIVE
  This study analyzed cancer incidence among man-made vitreous fiber workers.
  
  
  METHODS
  A cancer incidence follow-up was conducted among 3685 rock-slag wool (RSW) and 2611 glass wool (GW) production workers employed for > or =1 year in Denmark, Finland, Norway, or Sweden, and the standardized incidence ratios (SIR) were calculated on the basis of national incidence rates.
  
  
  RESULTS
  Overall cancer incidence was close to expectation. Lung cancer incidence was increased among the RSW [SIR 1.08, 95% confidence interval (95% CI) 0.85-1.36] and GW (SIR 1.28, 95% CI 0.91-1.74) workers. For both subcohorts, a trend was suggested for time since first employment (P-value for linear trend 0.1 and 0.2, respectively). Neither subcohort showed an association with employment during the early technological phase, when fiber exposure was high. The incidence of oral, pharyngeal, and laryngeal cancer was increased among the RSW (SIR 1.46, 95% CI 0.99-2.07) and the GW (SIR 1.41, 95% CI 0.80-2.28) subcohorts. Despite a trend in risk for these neoplasms among the GW workers with time since first employment, the lack of a positive relation with other indirect indicators of fiber exposure points against a causal interpretation. No association between RSW or GW exposure and the risk of other neoplasms was suggested.
  
  
  CONCLUSIONS
  These lung cancer results are similar to those of a mortality study that included a larger number of factories. For other cancers there was no suggestion of an association with RSW or GW exposure.
authors.affiliation: International Agency for Research on Cancer, Lyon, France. boffetta@iarc.fr
authors.forename: P
authors.initials: P
authors.lastname: Boffetta
authors.forename: A
authors.initials: A
authors.lastname: Andersen
authors.forename: J
authors.initials: J
authors.lastname: Hansen
authors.forename: J H
authors.initials: JH
authors.lastname: Olsen
authors.forename: N
authors.initials: N
authors.lastname: Plato
authors.forename: L
authors.initials: L
authors.lastname: Teppo
authors.forename: P
authors.initials: P
authors.lastname: Westerholm
authors.forename: R
authors.initials: R
authors.lastname: Saracci
mesh_terms: D006801:Humans; D015994:Incidence; D019016:Mineral Fibers; D009062:Mouth Neoplasms / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology*; D009784:Occupational Diseases / Q000453:epidemiology*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology
chemical_list: D019016:Mineral Fibers