Self-organizing molecular networks.
Strong diffusional mixing and short delivery times typical for micrometer and sub-micrometer reaction volumes lead to a special situation where the turnover times of individual enzyme molecules become the largest characteristic time scale of the chemical kinetics. Under these conditions, populations of cross-regulating allosteric enzymes form molecular networks that exhibit various kinds of self-organized coherent collective dynamics.
Stange
P
P
Abteilung Physikalische Chemie, Fritz-Haber-Institut der Max-Planck-Gesellschaft, Berlin, Germany.
Zanette
D
D
Mikhailov
A
A
Hess
B
B
D000494:Allosteric Regulation; D002468:Cell Physiological Phenomena; D004058:Diffusion; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances; D008954:Models, Biological; D013816:Thermodynamics
D004798:Enzymes; D046911:Macromolecular Substances