Return of fertility after successful chemotherapy treatment of gestational trophoblastic tumors.
OBJECTIVE
To determine the effect of chemotherapy on patients who wished to conceive after successful treatment of gestational trophoblastic disease. Patients-During a 12-year period (1984-1995), 90 patients with gestational trophoblastic tumor at Jordan University Hospital received repeated courses of chemotherapy; 85 patients are in continued remission (42 invasive mole and 43 choriocarcinoma). Fifty-five patients wished to conceive. Main outcome measures-Pregnancy, live births.


RESULTS
Forty-two patients (76%) achieved pregnancy, resulting in 20 pregnancies and 94 viable babies.


CONCLUSIONS
Chemotherapy is very effective in the cure of gestational trophoblastic tumors. Return of fertility compares favorably with the general population of the same reproductive age. There appears to be no increase in fetal congenital malformations.
Amr
M F
MF
Department of Obstetrics and Gynecology, Jordan University Hospital, Amman.
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002822:Choriocarcinoma / Q000188:drug therapy; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*