[Transcription factors of the Ets family and morphogenesis of the vascular tree].
The expression of several members of the Ets family of transcription factors, Ets1, Erg and Fli, correlates with the occurrence of invasive processes such as angiogenesis during normal and pathological development. The description of the phenotype of cultured endothelial cells expressing the DNA binding domain of Ets1 suggests that members of the Ets family take part in the morphogenesis of the vascular tree. Although transient transfection experiments allowed the identification of putative targets genes for Ets1 during angiogenesis, deciphering the Ets1 regulation networks remains a major goal for the future.
Mattot
V
V
CNRS EP560, Institut Pasteur de Lille, Institut de Biologie de Lille, France.
Vercamer
C
C
Soncin
F
F
Fafeur
V
V
Vandenbunder
B
B
D000818:Animals; D001808:Blood Vessels / Q000196:embryology; D004268:DNA-Binding Proteins / Q000378:metabolism; D051766:Early Growth Response Protein 1; D004730:Endothelium, Vascular / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017874:Immediate-Early Proteins; D009024:Morphogenesis; D050784:Proto-Oncogene Protein c-ets-1; D051789:Proto-Oncogene Protein c-fli-1; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D014162:Transfection
D004268:DNA-Binding Proteins; C497325:EGR1 protein, human; C494041:ETS1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D050784:Proto-Oncogene Protein c-ets-1; D051789:Proto-Oncogene Protein c-fli-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D015682:Retroviridae Proteins, Oncogenic; D015534:Trans-Activators; D014157:Transcription Factors
Les facteurs de transcription de la famille Ets et la morphogenèse du réseau vasculaire.