title: [Incidence of acute leukemias, lymphomas and thyroid cancers in children under 15 years, living around the Marcoule nuclear site from 1985 to 1995].
abstract: BACKGROUND
  The aim of this investigation was to report incidence of childhood leukemia, lymphoma and thyroid neoplasms in children under 15 years of age living in the vicinity of the French Marcoule nuclear reprocessing plant.
  
  
  METHODS
  This exhaustive and retrospective survey was carried out between 1985 and 1995 in children aged under 14 at the time of diagnosis and living inside a 35 kilometer zone around the nuclear site. 656 practitioners, 109 medical analysis laboratories and 5 hospitals or cancer institutes were investigated. A panel of experts checked each case.
  
  
  RESULTS
  48 cases of acute leukemia (39 acute lymphoid leukemia and 9 acute myeloid leukemia), 15 cases of lymphoma (8 Hodgkin lymphomas--53%--and 7 non hodgkinian lymphomas including 5 Burkitt lymphomas), 1 case of chronic myeloid leukemia and 1 case of papillary thyroid cancer, appeared among the 1,116,442 children-years followed. The total incidences of leukemias and lymphomas were respectively 4.12 and 1.29.10(-5). Standardised Incidence Ratios, calculated according to Poisson methods and bayesian inference, with various reference rates did not show any excess of risk: 100.67 (95% confidence interval 72-131) for leukemia. Children under 5 years old and living in non exposed areas to dominant winds or downstream rhodanian water drawing presented a 3 or 4 fold decreased risk of leukemia than others (the latter still having an identical risk to that of the general population). This was not true for lymphomas, nor for the other age groups.
  
  
  CONCLUSIONS
  Over the entire zone, children do not have an increased risk of malignant hematology disease but health monitoring by a systematic collection of cases remains useful around Marcoule. The assumption of aquiferous or air contamination thus still remains questionable: further studies investigating models of contamination are needed to take into account all other nonionizing leucemogenic factors (benzene and viral injection in particular) or correlation studies between health indicators and dosimetry.
authors.affiliation: Laboratoire d'Epidémiologie et de Biostatistiques-Institut Universitaire de Recherche Clinique de l'Université Montpellier I.
authors.forename: S
authors.initials: S
authors.lastname: Bouges
authors.forename: J P
authors.initials: JP
authors.lastname: Daurès
authors.forename: M
authors.initials: M
authors.lastname: Hébrard
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology; D008223:Lymphoma / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D009678:Nuclear Energy; D011159:Population Surveillance; D011210:Power Plants; D012111:Residence Characteristics; D012189:Retrospective Studies; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology*
vernacular_title: Incidence des leucémies aiguës, lymphomes et cancers thyroïdiens chez les enfants de moins de 15 ans vivant autour du site nucléaire de Marcoule de 1985 à 1995.