Expression of selectin families and their ligand sialyl Lewis X in the muscles of inflammatory myopathies: an immunohistochemical study.
OBJECTIVE
Adhesion molecules are suggested to play important roles in the pathogenesis of inflammatory diseases. We examined the expression of adhesion molecules in the muscles of human inflammatory myopathies.


METHODS
We immunohistochemically studied the expression and distribution of two molecules in the selectin family (E- and P-selectin) and their common ligand sialyl Lewis X in 18 inflammatory myopathies, 13 disease controls, and 16 normal controls.


RESULTS
In inflammatory myopathies, E- and P-selectin were upregulated on the surface of blood vessels, especially on the endothelial cells of the venules. Sialyl Lewis X was upregulated in the blood vessels, infiltrating leukocytes, and the surface of some atrophic myofibers. Some control muscles also showed weakly positive staining with these molecules, however, expression of these molecules was most striking in the muscles of inflammatory myopathies.


CONCLUSIONS
The results suggested that these molecules are upregulated in inflammatory myopathies and might play a role in the pathogenesis of inflammatory myopathies.
Jimi
T
T
Department of Medicine, Showa University Fujigaoka Hospital, Yokohama.
Wakayama
Y
Y
Murahashi
M
M
Inoue
M
M
Shibuya
S
S
Yamashita
S
S
Misugi
N
N
Kobayashi
T
T
D015815:Cell Adhesion Molecules / Q000032:analysis; D019040:E-Selectin / Q000378:metabolism*; D006801:Humans; D016256:Lewis X Antigen / Q000378:metabolism; D009220:Myositis / Q000276:immunology* / Q000473:pathology; D009468:Neuromuscular Diseases / Q000276:immunology* / Q000473:pathology; D009844:Oligosaccharides / Q000378:metabolism*; D019007:P-Selectin / Q000378:metabolism*; D012016:Reference Values; D000080506:Sialyl Lewis X Antigen; D015854:Up-Regulation
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016256:Lewis X Antigen; D009844:Oligosaccharides; D019007:P-Selectin; D000080506:Sialyl Lewis X Antigen