Synthesis and antiviral activities of 1,3-oxathiolanyl nucleosides with 5-hydroxymethyl substituent.
Novel 1,3-oxathiolanyl pyrimidine nucleosides with 5-hydroxymethyl substituent were synthesized starting from D-mannose and evaluated for antiviral activities against HIV-1, HSV type 1,2 and HCMV.
Chun
M W
MW
College of Pharmacy, Seoul National University, Korea.
Choi
S P
SP
Kim
M J
MJ
Bae
C J
CJ
Moon
H R
HR
Kim
H D
HD
Jeong
L S
LS
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D009705:Nucleosides