title: [Glucotoxicity and lipotoxicity, two implicated accomplices in the vicious circle of type 2 diabetes].
abstract: Type 2 diabetes mellitus is a dynamic disease whose natural history is characterized by a progressive aggravation leading to a progressively severe hyperglycaemia, which generally requires a more complex therapy as time progresses. Such an evolution results from a vicious circle where both glucotoxicity and lipotoxicity contribute to reduce insulin secretion and the action of insulin on cell glucose metabolism. These new concepts are able to modify the strategies of prevention and treatment of type 2 diabetes.
authors.affiliation: Département de Médecine, CHU Sart Tilman, Liège.
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
authors.forename: N
authors.initials: N
authors.lastname: Paquot
authors.forename: P J
authors.initials: PJ
authors.lastname: Lefèbvre
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000517:prevention & control / Q000628:therapy; D018450:Disease Progression; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D050356:Lipid Metabolism
chemical_list: D007328:Insulin; D005947:Glucose
vernacular_title: Glucotoxicité et lipotoxicité, deux complices impliqués dans le cercle vicieux du diabète de type 2.