title: Identification of the dimethylbenzyl mercapturic acid in urine of rats treated with 1,2,3-trimethylbenzene.
abstract: The structure was investigated of the mercapturic acid excreted in urine of rats after the i.p. administration of 1,2,3-trimethylbenzene. Of the two regioisomeric mercapturic acids, i.e. N-acetyl-S-(2,3-dimethylbenzyl)-L-cysteine and N-acetyl-S-(2,6-dimethyl-benzyl)-L-cysteine, only the former was isolated by preparative HPLC and identified, by comparison with an authentic specimen. The excretion rate of the mercapturate was estimated to be approximately 5% of dose, not a substantial metabolic route.
authors.affiliation: Osaka City Institute of Public Health and Environmental Sciences, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tsujimoto
authors.forename: T
authors.initials: T
authors.lastname: Noda
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000111:Acetylcysteine / Q000737:chemistry / Q000652:urine*; D000818:Animals; D001555:Benzene Derivatives / Q000008:administration & dosage / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004785:Environmental Pollutants; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001555:Benzene Derivatives; D004785:Environmental Pollutants; C010179:hemimellitene; D000111:Acetylcysteine