title: Influence of age and hormonal treatment on intestinal absorption of magnesium in ovariectomised rats.
abstract: This study was designed to assess the effect of age, ovariectomy and estrogen treatment on the absorption and the balance of Mg in the rat. Three groups of fifteen 6- (mature), 12- (old), and 30-month-old female rats (senescent), fed a diet containing 1.5 g of Mg/kg were used in the present study. Within each group, 10 rats were surgically ovariectomized (OVX). From day 2 until day 60 after OVX, they were s.c. injected with either solvant or 17 beta-estradiol (E: 10 mg/kg bw/48 h, n = 5). Five other rats were sham operated (SH, n = 5) and received solvent alone. Animals were pair fed 6 g/100 g bw/day and distilled water was available ad libitum. Food intake, urine and feces from each individual rat were measured 1 day per week, during the last 5 weeks. The results clearly showed that apparent Mg absorption (per cent) was not significantly altered with aging. Moreover, whatever the age, neither OVX nor E treatment had any significant effect on Mg apparent absorption.
authors.affiliation: Centre de Recherche en Nutrition Humaine d'Auvergne, INRA-Unité Maladies Métaboliques et Micronutriments, St-Genès-Champanelle, France. charles.coudray@clermont.inra.fr
authors.forename: C
authors.initials: C
authors.lastname: Coudray
authors.forename: N
authors.initials: N
authors.lastname: Gaumet
authors.forename: J
authors.initials: J
authors.lastname: Bellanger
authors.forename: V
authors.initials: V
authors.lastname: Coxam
authors.forename: J P
authors.initials: JP
authors.lastname: Barlet
authors.forename: Y
authors.initials: Y
authors.lastname: Rayssiguier
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D008274:Magnesium / Q000378:metabolism* / Q000652:urine; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000187:drug effects
chemical_list: D004958:Estradiol; D008274:Magnesium