title: Use of injectable autologous collagen for correcting glottic gaps: initial results.
abstract: We report our results pertaining to the use of injectable autologous collagen for the correction of dysphonia resulting from a glottic gap. To date 20 cases have been treated, 13 of which were for unilateral vocal fold immobility and 7 for sulcus vergeture and/or scar. Collagen is extracted from the skin. Approximately 5 cm2 is necessary to yield 2 ml. Injection must take place in the deep layer of Reinke's space. No patient suffered from any local or general intolerance. The phonatory glottic gap was totally or partially closed. In the paralysis group, the improvements were the following: the median maximum phonation time improved from 5.8 seconds to 11 seconds, the median mean flow rate from 0.13 ml/s to 0.09 ml/s, the median glottic gap from 8.4 to 4.5 ml/dB per s, the median intensity range from 21 to 29 dB, and the median frequency range from 141 to 195 Hz. The spectral analysis layout classification improved from 2 to 3.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital of Louvain at Mont-Godinne, Yvoir, Belgium. remacle@orlo.ucl.ac.be
authors.forename: M
authors.initials: M
authors.lastname: Remacle
authors.forename: G
authors.initials: G
authors.lastname: Lawson
authors.forename: J
authors.initials: J
authors.lastname: Keghian
authors.forename: J
authors.initials: J
authors.lastname: Jamart
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005931:Glottis; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014826:Vocal Cord Paralysis / Q000150:complications; D014832:Voice Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D003094:Collagen