title: The effect of age and pre-light melatonin concentration on the melatonin sensitivity to dim light.
abstract: The hormone melatonin is secreted at night from the pineal gland, with light being a potent inhibitor of its secretion. Age related decreases in plasma melatonin concentrations have indicated that this may be related to pineal calcification with aging. Recently, it was shown that the melatonin sensitivity to light may be a biological marker of bipolar disorder. However, on average, patients were older than the control group in most studies, and it is not known if age has an effect on the melatonin suppression by light. To test this hypothesis, the present study investigated the effect of age on the melatonin sensitivity to dim light (200 lux). Participants were grouped into three age groups. On the testing night, they were placed in a dark room from 21.00 h to 02.30 h. Light exposure was for an hour from midnight to 01.00 h. Blood samples were collected at regular intervals for measurement of plasma melatonin. No significant differences were found in the percentage suppression of melatonin within the age groups defined in the present study (P > 0.5). No correlation was also found between age and percentage suppression of melatonin (r2 = 0.007; P > 0.1). Our results suggest that the melatonin suppression by light (200 lux) is not affected by age.
authors.affiliation: Brain Sciences Institute, Swinburne University of Technology, Hawthorn, Victoria, Australia. pnathan@bsi.swin.edu-au
authors.forename: P J
authors.initials: PJ
authors.lastname: Nathan
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
authors.forename: T R
authors.initials: TR
authors.lastname: Norman
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D019540:Area Under Curve; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D010775:Photic Stimulation; D011863:Radioimmunoassay
chemical_list: D008550:Melatonin