Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands.
Tetrapeptide derived major histocompatability (MHC) II ligands have been developed that contain no unadulterated peptide bonds. These are the 'least peptidic' ligands for any MHC protein yet reported.
Jones
A B
AB
Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Acton
J J
JJ
Adams
A D
AD
Yuen
W
W
Nichols
E A
EA
Schwartz
C D
CD
Wicker
L S
LS
Hermes
J D
JD
D015195:Drug Design; D000949:Histocompatibility Antigens Class II / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D007769:Lactams / Q000737:chemistry; D008024:Ligands; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000949:Histocompatibility Antigens Class II; D007769:Lactams; D008024:Ligands; D010455:Peptides