title: [Treatment concepts in osseous manifestations of Langerhans cell histiocytosis].
abstract: BACKGROUND
  Patients with Langerhans Cell Histiocytosis (LCH or Eosinophilic granuloma) were assessed from the orthopaedic point of view to give recommendations for the management of the disease.
  
  
  METHODS
  The results of 36 cases of histologically proven bony manifestations out of 48 treated cases were reviewed. A retrospective analysis of our treated cases with bony manifestations of LCH between 1970 and 1995 was performed.
  
  
  RESULTS
  Twenty-two cases exhibited isolated bony manifestations, 18 were monoostotic and 4 were polyostotic. We treated 14 cases with multi-organ disease including bony manifestations of LCH. In the cases of exclusive bony manifestations reactivations were rare and usually occurred in other bones.
  
  
  CONCLUSIONS
  In order to assure stability local control is the general goal of orthopaedic treatment. In isolated lesions control can be achieved by excochleation and filling with cancellous bone or prednisolon instillation. Multiple lesions should be treated primarily by systemic drugs and operative procedures are only necessary if severe local problems occur. Additionally, we recommend interdisciplinary cooperation between ortopedic surgeon, pediatrist and pathologist.
authors.affiliation: Orthopädische Universitätsklinik Magdeburg.
authors.forename: W
authors.initials: W
authors.lastname: Nebelung
authors.forename: M
authors.initials: M
authors.lastname: Röpke
authors.forename: U
authors.initials: U
authors.lastname: Kluba
authors.forename: V
authors.initials: V
authors.lastname: Aumann
authors.forename: K
authors.initials: K
authors.lastname: Radig
authors.forename: U
authors.initials: U
authors.lastname: Mittler
mesh_terms: D000293:Adolescent; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D010348:Patient Care Team; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011239:Prednisolone / Q000008:administration & dosage; D011859:Radiography; D012189:Retrospective Studies
chemical_list: D011239:Prednisolone
vernacular_title: Behandlungskonzepte ossärer Manifestationen der Langerhanszellhistiozytose.