title: Association of estrogen receptor gene polymorphisms with endometriosis.
abstract: OBJECTIVE
  To explore the association of the estrogen receptor two-allele (point) polymorphism and multiallele (microsatellite) polymorphism with endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Genetics and Endoscopy Unit, Department of Obstetrics and Gynecology, Ioannina University HOSPITAL, Ioannina, Greece.
  
  
  METHODS
  Fifty-seven women with surgically and histologically diagnosed endometriosis of stages I-IV.
  
  
  METHODS
  Diagnostic laparoscopy.
  
  
  METHODS
  Frequency and distribution of the estrogen receptor gene polymorphisms.
  
  
  RESULTS
  There was a statistically significant difference between the patients and the controls in the frequency of the two-allele Pvu II polymorphism (0.72 vs. 0.49) and in the median repeats of the (TA)n multiallele polymorphism (15 vs. 20 repeats). In both groups, linkage was found between the fewer (TA)n repeats (range, 12-19) and the positive Pvu II polymorphism.
  
  
  CONCLUSIONS
  The variability of the estrogen receptor gene likely contributes to the pathogenesis of endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Ioannina University Hospital and Ioannina University Medical School, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Georgiou
authors.forename: M
authors.initials: M
authors.lastname: Syrrou
authors.forename: I
authors.initials: I
authors.lastname: Bouba
authors.forename: N
authors.initials: N
authors.lastname: Dalkalitsis
authors.forename: M
authors.initials: M
authors.lastname: Paschopoulos
authors.forename: I
authors.initials: I
authors.lastname: Navrozoglou
authors.forename: D
authors.initials: D
authors.lastname: Lolis
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D011960:Receptors, Estrogen