Serum protein binding of desmethyl-methsuximide.
Serum protein binding of desmethyl-methsuximide (DM-MSM) in serum from 23 patients on polytherapy were determined using ultrafiltration and high-performance liquid chromatography. Desmethyl-methsuximide, The active metabolite of methsuximide (MSM), was found to have a moderate protein binding ranging between 45% and 60%.
Wad
N
N
Swiss Epilepsy Centre, Zurich, Switzerland.
Bourgeois
B
B
Krämer
G
G
D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D011485:Protein Binding; D012640:Seizures / Q000188:drug therapy; D013388:Succinimides / Q000097:blood* / Q000378:metabolism* / Q000627:therapeutic use
D000927:Anticonvulsants; D013388:Succinimides; C100286:methsuximide; C018504:N-desmethylmethsuximide