title: Diagnosis of anaplastic large-cell lymphoma, including multifocal osseous KI-1 lymphoma, by fine-needle aspiration biopsy.
abstract: We present the fine-needle aspiration (FNA) findings of 4 cases of anaplastic (Ki-1) large-cell lymphoma (ALCL). A primary diagnosis of ALCL was made on FNA material in 2 cases, of which one was a multifocal osseous Ki-1 lymphoma. In the other 2 patients who had a known history of ALCL, FNA was used to detect recurrent disease. In all cases, large discohesive pleomorphic cells in the absence of lymphoglandular bodies in the background raised the possibility of a nonhematopoietic neoplasm. Immunochemical staining for CD30 was positive in all cases. The cytomorphologic and immunochemical features are discussed, along with the differential diagnosis of Ki-1 lymphoma. Diagn. Cytopathol. 1999;21:174-179.
authors.affiliation: Division of Cytopathology, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: L G
authors.initials: LG
authors.lastname: Dodd
authors.forename: B M
authors.initials: BM
authors.lastname: Osborne
authors.forename: S
authors.initials: S
authors.lastname: Martinez
authors.forename: B A
authors.initials: BA
authors.lastname: Olatdioye
authors.forename: J F
authors.initials: JF
authors.lastname: Madden
mesh_terms: D000293:Adolescent; D000368:Aged; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017730:Ki-1 Antigen / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence
chemical_list: D017730:Ki-1 Antigen