title: [Clinical significance of urothelial dysplasia concomitant with superficial bladder cancer].
abstract: OBJECTIVE
  Retrospective analysis was carried out to evaluate the prognostic value of urothelial dysplasia with superficial bladder cancer.
  
  
  METHODS
  62 patients with bladder cancer of pTa or pT1 who had been treated by transurethral resection (TUR-Bt), underwent random mucosal biopsies in the urinary bladder. The results of random biopsies were classified into 3 groups: negative group, dysplasia group and CIS group. The recurrence rate, progression rate and type of recurrences (true recurrence/new occurrence) were compared among the 3 groups.
  
  
  RESULTS
  The results of random biopsies were as follows; negative group was found in 42 (68%), dysplasia group in 17 (27%) and CIS group in 3 (5%). There were no significant difference in the characteristics of the patients among the 3 groups. The recurrence rates at 1, 2 and 5 years after TUR-Bt were 3%, 12% and 21%, respectively, for negative group, and 37%, 51% and 67%, respectively, for dysplasia group (p < 0.01). For CIS group, 2 of 3 cases (67%) recurrenced within 1 year after TUR-Bt. Non of negative group progressed to muscle invasion, whereas 57% of dysplasia group invaded bladder muscle after 6 years post operatively (p < 0.001). No significant relationship was observed between the absence or presence of concomitant dysplasia and the rate of true recurrence. Dysplasia group revealed a higher rate (47.1%) of new occurrence than negative group (2.4%) (p = 0.0001).
  
  
  CONCLUSIONS
  The presence or absence of concomitant dysplasia of superficial bladder cancer seems to be an important prognostic factor for future new ocurrence and progression after TUR-Bt.
authors.affiliation: Department of Urology, Fukuoka University Chikushi Hospital, Chikushino, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: F
authors.initials: F
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Hiratsuka
authors.forename: A
authors.initials: A
authors.lastname: Ariyoshi
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D011897:Random Allocation; D012189:Retrospective Studies; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery; D019459:Urothelium / Q000473:pathology