title: Methylenecyclopropane analogues of nucleosides: synthesis, absolute configuration, and enantioselectivity of antiviral effect of (R)-(-)- and (S)-(+)-synadenol.
abstract: Synthesis, absolute configuration and antiviral activity of enantiomeric antiviral agents (R)-(-)- and (S)-(+)-synadenol (2 and 3a) are described.
authors.affiliation: Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.
authors.forename: Y L
authors.initials: YL
authors.lastname: Qiu
authors.forename: A
authors.initials: A
authors.lastname: Hempel
authors.forename: N
authors.initials: N
authors.lastname: Camerman
authors.forename: A
authors.initials: A
authors.lastname: Camerman
authors.forename: F
authors.initials: F
authors.lastname: Geiser
authors.forename: R G
authors.initials: RG
authors.lastname: Ptak
authors.forename: J M
authors.initials: JM
authors.lastname: Breitenbach
authors.forename: T
authors.initials: T
authors.lastname: Kira
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: E
authors.initials: E
authors.lastname: Gullen
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
authors.forename: J C
authors.initials: JC
authors.lastname: Drach
authors.forename: J
authors.initials: J
authors.lastname: Zemlicka
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D003521:Cyclopropanes; C116544:synadenol; D000225:Adenine