title: [Dynamics of antibiotic biosynthesis by Streptomyces chrysomallus with different plasmid status in submerged and surface culture].
abstract: The dynamics of simultaneous production of two antibiotic substances of different structure by the same species streptomycete was studied. The comparative investigation of accumulation of actinomycin C (AC) and macrotetrolides (MTL) was performed in aerated submerged culture and on surface culture with three strains of Streptomyces chrysomallus of different plasmid status and with their bld mutants. It was shown that the dynamics of the AC and MTL production was different in the liquid medium and on the agarized medium. The maxima of the AC and MTL production were observed at different stages of the S.chrysomallus development which was likely due to different physiological roles of the two antibiotics in S.chrysomallus. The character of the MTL accumulation in the culture of bld mutants differed from that of the starting strains. By the level and dynamics of the antibiotics biosynthesis S.chrysomallus BKM Ac-590 and its mutants containing plasmids pSCH2 and pSCH3 differed from the other strains.
authors.affiliation: M.V. Lomonosov Moscow State University.
authors.forename: G I
authors.initials: GI
authors.lastname: Efron-Konoshenko
mesh_terms: D000362:Agar; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D005782:Gels; D009154:Mutation; D010957:Plasmids / Q000235:genetics*; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D005782:Gels; D000362:Agar
vernacular_title: Issledovanie dinamiki biosinteza antibiotikov shtammami Streptomyces chrysomallus s razlichnym plazmidnym statusom v pogruzennoĭ i poverkhnostnoĭ kul'ture.