Perioperative antibiotic prophylaxis in maxillofacial surgery: penetration of clindamycin into various tissues.
Although clindamycin is recommended for prophylactic use in oral and maxillofacial surgery, there is little data available regarding its ability to provide sufficient tissue concentrations at the operative site. We investigated tissue samples from 31 patients, who had to undergo oral and maxillofacial surgery and who received at least one dose of 600 mg clindamycin i.v. preoperatively, to determine clindamycin tissue concentrations in muscle, oral mucosa, fatty tissue, skin and bone between 15 min and 8 h after administration. After homogenization, clindamycin concentration was determined by bioassay. It was demonstrated that clindamycin concentrations above the MIC90 of those pathogens most likely to cause contamination were reached in all kinds of tissues investigated. Already 15 min after administration, tissue concentrations above the MIC90 were reached and were still detectable in the last samples taken between 4 and 8 h after the last clindamycin administration. From the pharmacokinetic point of view, clindamycin is suitable for perioperative prophylaxis during oral and maxillofacial surgery providing sufficient tissue concentrations with no intraoperative additional dosage necessary unless procedures exceed 4 h duration.
Mueller
S C
SC
Department of Clinical Pharmacology, Institute of Pharmacology and Toxicology, Universität Rostock, Germany.
Henkel
K O
KO
Neumann
J
J
Hehl
E M
EM
Gundlach
K K
KK
Drewelow
B
B
D000042:Absorption; D000328:Adult; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002981:Clindamycin / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures; D013997:Time Factors; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D002981:Clindamycin