title: Lack of response to octreotide in Cushing's syndrome due to metastatic adrenocortical carcinoma.
abstract: Functional metastatic adrenocortical carcinoma is an uncommon cause of Cushing's syndrome, which rarely responds to conventional treatment. A patient presenting with Cushing's syndrome secondary to adrenocortical carcinoma underwent surgical resection. Postoperatively, she developed metastatic disease resistant to conventional chemotherapy. Octreotide, a somatostatin analogue which is effective in the treatment of several types of neuroendocrine tumour, was tried to ameliorate her secretory symptoms, but without any therapeutic effect.
authors.affiliation: Department of Endocrinology, Imperial College School of Medicine, Chelsea & Westminster Hospital, London, UK.
authors.forename: N N
authors.initials: NN
authors.lastname: Chan
authors.forename: A J
authors.initials: AJ
authors.lastname: Isaacs
mesh_terms: D018268:Adrenocortical Carcinoma / Q000150:complications*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D015282:Octreotide / Q000627:therapeutic use*; D013004:Somatostatin / Q000031:analogs & derivatives
chemical_list: D000893:Anti-Inflammatory Agents; D006728:Hormones; D013004:Somatostatin; D015282:Octreotide; D006854:Hydrocortisone