title: Interictal and postictal cognitive changes in migraine.
abstract: The question whether symptom-free migraine patients show cognitive impairments compared to matched control subjects is addressed, and also whether migraine patients show transient cognitive impairments induced by an attack. The Neuropsychological Evaluation System (NES2) was administered once in an interictal period and twice within 30 h after different migraine attacks. Since cognitive impairments could be related to attack duration or severity, cognitive performance was compared during a postictal period after sumatriptan use and during a postictal period after habitual nonvasoactive medication use. Twenty migraineurs without aura, 10 migraineurs with aura, and 30 matched headache-free controls participated in the study. During a headache-free period, migraineurs without aura responded as quickly as controls, while migraineurs with aura were slower than controls during all tasks specifically requiring selective attention. These effects were not aggravated by a preceding migraine attack, irrespective of medication use and attack duration.
authors.affiliation: Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. EJCM.Mulder@psy.vu.nl
authors.forename: E J
authors.initials: EJ
authors.lastname: Mulder
authors.forename: W H
authors.initials: WH
authors.lastname: Linssen
authors.forename: J
authors.initials: J
authors.lastname: Passchier
authors.forename: J F
authors.initials: JF
authors.lastname: Orlebeke
authors.forename: E J
authors.initials: EJ
authors.lastname: de Geus
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects; D003072:Cognition Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D019965:Neurocognitive Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D009483:Neuropsychological Tests; D010147:Pain Measurement; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D018170:Sumatriptan / Q000009:adverse effects / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D018170:Sumatriptan