title: Role of hepatic, intrahepatic and hepatoenteral nerves in the regulation of carbohydrate metabolism and hemodynamics of the liver and intestine.
abstract: The liver as an effector organ is the major glucose reservoir, the utilization of which is controlled by hormones but also by hepatic sympathetic nerves. The liver as a sensory organ detects a glucose concentration gradient between the hepatic artery and the portal vein by intrahepatic sensory-effector nerves, generating a cholinergic signal for an insulin-dependent net hepatic glucose uptake. The liver senses the insulin concentration by hepatoenteral sensory-effector nerves, generating a cholinergic signal to increase glucose absorption in the intestine and thus its coordinated utilization in liver, muscle and adipose tissue.
authors.affiliation: Institut für Biochemie und Molekulare Zellbiologie, Göttingen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Jungermann
authors.forename: F
authors.initials: F
authors.lastname: Stümpel
mesh_terms: D000344:Afferent Pathways; D000818:Animals; D050260:Carbohydrate Metabolism; D004525:Efferent Pathways; D006439:Hemodynamics; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000294:innervation; D008099:Liver / Q000294:innervation* / Q000378:metabolism* / Q000502:physiology; D009475:Neurons, Afferent; D010275:Parasympathetic Nervous System; D013564:Sympathetic Nervous System