[The pathogenetic characteristics and the possible ways for the pharmacological correction of insulin-dependent diabetes mellitus].
This work reflects the modern concepts of the pathogenesis of insulin-dependent diabetes mellitus and the prospective trends of pharmacological correction, analyzes the possibility of including in the therapeutic complex antiviral drugs, immunocorrecting measures, antioxidants, inhibitors of aldose reductase, amino guanidine, SH-group donors, and new medicamentous forms of insulin. Problems of an individual choice of drugs with consideration for the stage-development of the disease, the main pathogenetic mechanisms, the chronobiological rhythm of drug prescription, and adequate control of the efficacy of the applied pharmacotherapy are discussed.
Chernov
Iu N
IuN
Department of Clinical Pharmacology, Voronezh State Medical Academy, Russia.
Pashkov
A N
AN
Vasin
M V
MV
Batishcheva
G A
GA
Zolotarev
D V
DV
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D002940:Circadian Rhythm; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D014777:Virus Diseases / Q000150:complications
D007004:Hypoglycemic Agents; D007328:Insulin
Osobennosti patogeneza i vozmozhnye puti farmakologicheskoĭ korrektsii insulinzavisimoogo sakharnogo diabeta.