Ventilatory instability during sleep onset in individuals with high peripheral chemosensitivity.
Previous work has shown that the magnitude of state-related ventilatory fluctuations is amplified over the sleep-onset period and that this amplification is partly due to peripheral chemoreceptor activity, because it is reduced by hyperoxia (J. Dunai, M. Wilkinson, and J. Trinder. J. Appl. Physiol. 81: 2235-2243, 1996). These data also indicated considerable intersubject variability in the magnitude of amplification. A possible source of this variability is individual differences in peripheral chemoreceptor drive (PCD). We tested this hypothesis by measuring state-related ventilatory fluctuations throughout sleep onset under normoxic and hyperoxic conditions in subjects with high and low PCD. Results demonstrated that high-PCD subjects experienced significantly greater amplification of state-related ventilatory fluctuations than did low-PCD subjects. In addition, hyperoxia significantly reduced the amplification effect in high-PCD subjects but had little effect in low-PCD subjects. These results indicate that individuals with high PCD are likely to experience greater sleep-related ventilatory instability and suggest that peripheral chemoreceptor activity can contribute to sleep-disordered breathing.
Dunai
J
J
Department of Psychology, School of Behavioural Science, University of Melbourne, Parkville, Victoria 3052, Australia.
Kleiman
J
J
Trinder
J
J
D000328:Adult; D002628:Chemoreceptor Cells / Q000378:metabolism*; D004594:Electrophysiology; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000378:metabolism; D012123:Pulmonary Ventilation / Q000502:physiology*; D012119:Respiration; D012867:Skin / Q000187:drug effects*; D012894:Sleep Stages / Q000502:physiology*; D012122:Ventilators, Mechanical
D010100:Oxygen