title: Effect of biochemical components on rheologic properties of nasal mucus in chronic sinusitis.
abstract: The effect of biochemical components on the viscoelasticity of nasal mucus from 24 patients with chronic sinusitis (CS) was investigated by multiple stepwise regression analysis. The dynamic viscosity (eta') and the elastic modulus (G') of nasal mucus were determined with an oscillating sphere magnetic rheometer at oscillatory frequencies of 1 and 10 Hz. The eta' and G' values of mucus determined at 1 Hz were 1.6 +/- 1.5 Pa/s and 31.8 +/- 31.0 Pa, respectively, and these values were much higher than optimal viscoelasticity for mucociliary transport. The concentrations of fucose, N-acetyl neuraminic acid, albumin, IgG, secretory-IgA, and lysozyme were measured in the same mucus samples. The multiple regression analysis showed that the concentration of fucose, a marker of mucous glycoproteins, was the most important determinant of eta' and G'. The analysis also revealed that the level of IgG was the next important determinant. The coefficients of multiple determination for fucose and IgG were 0.732 and 0.733 when the response variables were eta' and G', respectively. The results indicate that locally produced mucous glycoproteins may largely contribute to the high viscoelasticity of nasal mucus in CS.
authors.affiliation: Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Majima
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakura
authors.forename: S
authors.initials: S
authors.lastname: Yasuoka
authors.forename: S
authors.initials: S
authors.lastname: Yoshinaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D005260:Female; D005643:Fucose / Q000032:analysis / Q000502:physiology; D006023:Glycoproteins / Q000032:analysis / Q000502:physiology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000737:chemistry / Q000502:physiology*; D012044:Regression Analysis; D012212:Rheology; D012852:Sinusitis / Q000503:physiopathology*; D014783:Viscosity
chemical_list: D006023:Glycoproteins; D007074:Immunoglobulin G; D005643:Fucose