Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).
Butyrylcholinesterase (BCHE) is an enzyme expressed in most human tissues. Recently, an increased odds of carrying the K variant of BCHE (BCHE-K) was reported among Alzheimer disease (AD) cases as compared with controls. We tested our data set of 245 sporadic AD cases and 241 controls for an association between BCHE-K, APOE4, and AD using logistic regression and chi-square analyses. The sib transmission disequilibrium test (S-TDT) was also used to test for differences in BCHE-K allele frequencies between 163 discordant sib-pairs selected from multiplex AD families. No statistically significant differences were noted between BCHE-K case and control allele frequencies even after stratifying by APOE4 status. S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52). We conclude that BCHE-K is not a major genetic risk factor for AD in our study population.
Grubber
J M
JM
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Saunders
A M
AM
Crane-Gatherum
A R
AR
Scott
W K
WK
Martin
E R
ER
Haynes
C S
CS
Conneally
P M
PM
Small
G W
GW
Roses
A D
AD
Haines
J L
JL
Pericak-Vance
M A
MA
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002091:Butyrylcholinesterase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D016017:Odds Ratio; D010375:Pedigree
D001057:Apolipoproteins E; D002091:Butyrylcholinesterase