[Tissue plasminogen activator and diabetes mellitus].
tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.
Galajda
P
P
I. interná klinika MFN, Martin.
Martinka
E
E
Kubisz
P
P
Mokán
M
M
D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D010959:Tissue Plasminogen Activator / Q000378:metabolism / Q000502:physiology*
D010959:Tissue Plasminogen Activator
Tkanivový aktivátor plazminogénu (tPA) a diabetes mellitus.