title: Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep.
abstract: Experimental vaccine trials against hydatid disease have been undertaken in sheep using the EG95 recombinant vaccine. Challenge infection was with viable Echinococcus granulosus eggs obtained from a New Zealand isolate (dog/sheep cycle), an Australian isolate (dingo/wallaby cycle) and an Argentine isolate (dog/sheep cycle). Vaccination with EG95 conferred a high degree of protection against challenge with all three parasite isolates (protection range 96-100%). Taken together, the trials demonstrated that 86% of vaccinated sheep were completely free of viable hydatid cysts when examined approximately 1 year after challenge infection. Vaccination reduced the number of viable cysts by 99.3% compared with unvaccinated controls. These results suggest that the EG95 vaccine could have wide applicability as a new tool for use in hydatid control campaigns.
authors.affiliation: Molecular Parasitology Laboratory, The University of Melbourne, Vic. Australia. marshall@unimelb.edu.au
authors.forename: M W
authors.initials: MW
authors.lastname: Lightowlers
authors.forename: O
authors.initials: O
authors.lastname: Jensen
authors.forename: E
authors.initials: E
authors.lastname: Fernandez
authors.forename: J A
authors.initials: JA
authors.lastname: Iriarte
authors.forename: D J
authors.initials: DJ
authors.lastname: Woollard
authors.forename: C G
authors.initials: CG
authors.lastname: Gauci
authors.forename: D J
authors.initials: DJ
authors.lastname: Jenkins
authors.forename: D D
authors.initials: DD
authors.lastname: Heath
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology / Q000627:therapeutic use*; D001118:Argentina; D001315:Australia; D004285:Dogs; D004443:Echinococcosis / Q000276:immunology / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D004446:Echinococcus / Q000276:immunology; D005260:Female; D008137:Longitudinal Studies; D007614:Macropodidae / Q000469:parasitology; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology / Q000517:prevention & control*; D013045:Species Specificity; D014614:Vaccines, Synthetic / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000947:Antigens, Helminth; D014614:Vaccines, Synthetic