[The effect of autolymph on peripheral blood antioxidants in lung cancer patients].
To establish the effect of autolymphochemotherapy on enzymatic and non-enzymatic systems of antioxidant protection of plasma and formed elements in blood of lung cancer patients, certain indices of peroxidation processes were simulated using a model containing blood and autolymph (with chemopreparations) sampled from patients with lung tumors. Autolymph injection into the patients' blood stream was followed on the basis moderate stress reaction which of caused reactions of endogenous antioxidants to oscillate. However, the structure and function of cellular membranes of formed elements were not affected. Chemotherapy neither aggravated stress condition nor did it exert direct cytotoxic effect on blood cells.
Sidorenko
Iu S
IuS
Research Institute of Oncology, Ministry of Health of the RF, Rostov-on-Don.
Frantsiiants
E M
EM
Musienko
N V
NV
Tkacheva
G N
GN
Shalashnaia
E V
EV
Kartashov
S Z
SZ
Kas'ian
E G
EG
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism*; D001769:Blood / Q000187:drug effects*; D001773:Blood Cells / Q000187:drug effects; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007267:Injections; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000276:immunology*; D008196:Lymph / Q000276:immunology*; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D010949:Plasma / Q000187:drug effects; D014182:Transplantation, Autologous
D000975:Antioxidants
Vliianie autolimfy na sistemu antiokislitel'noĭ zashchity perifericheskoĭ krovi bol'nykh rakom legkogo.