Terminal deletion of chromosome 10q at band 26.1: follow-up in an adolescent male with high-output renal failure from congenital obstructive uropathy.
We report on the clinical findings in an adolescent male with a de novo terminal deletion of chromosome 10 del(10)(q26.1). This young man is one of the oldest known patients reported with this condition. His condition is compared with that of 11 reported cases of de novo terminal deletion of 10q at band 26. Individuals with chromosome 10q26 deletion have some findings and medical complications in common. Our patient has chronic renal failure due to urinary tract obstruction from posterior urethral valves. Similar anomalies have been reported in cases of 10q26 deletion, suggesting a careful renal/urinary tract evaluation should be completed in individuals with this condition.
Leonard
N J
NJ
Department of Medical Genetics, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada. leonard@ualberta.ca
Harley
F L
FL
Lin
C C
CC
D000293:Adolescent; D002648:Child; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D051437:Renal Insufficiency / Q000235:genetics; D014517:Ureteral Obstruction / Q000235:genetics