Toxicity associated with a prolonged half-life of phenytoin in a 97-year-old woman: bezoar formation? Case report and clinical pathological conference.
Phenytoin metabolism is best described using nonlinear (Michaelis-Menton) kinetics. When calculated pharmacokinetic values, including half life and clearance, do not correspond to measured variables, alternative reasons must be sought. We present an interesting case of phenytoin toxicity and suggest that formation of a bezoar may be one possible answer to prolonged toxicity.
Freedman
M D
MD
Sinai Hospital of Baltimore and The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sencil
S K
SK
D000368:Aged; D000369:Aged, 80 and over; D001630:Bezoars / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects* / Q000493:pharmacokinetics
D010672:Phenytoin