title: Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depression.
abstract: The authors examined whether cerebrovascular risk factors (CVRFs) are associated with depressive diagnoses and symptoms in 303 primary-care patients age >/=60 years, as would be consistent with a small-vessel brain disease model of later-life depression. CVRFs were not significantly independently associated with major, minor, or subsyndromal depression, late-onset major depression, or overall depressive symptom severity. These data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings. Future work should include longitudinal study with larger sample sizes.
authors.affiliation: Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA. Jeffrey_Lyness@urmc.rochester.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Lyness
authors.forename: E D
authors.initials: ED
authors.lastname: Caine
authors.forename: D A
authors.initials: DA
authors.lastname: King
authors.forename: Y
authors.initials: Y
authors.lastname: Conwell
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: P R
authors.initials: PR
authors.lastname: Duberstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000523:psychology; D003863:Depression / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D011320:Primary Health Care / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012307:Risk Factors; D012494:Sampling Studies