[Effects of locally used SD zinc, SD silver and skin transplantation on the combined radiation-burn injury in the rat].
Effects of local use of sulfadiazine (SD) zinc, SD silver in the wound and skin transplantation on the combined injury of 6 Gy radiation and 15% TBSA burn were investigated in the present study. In the three groups of SD zinc or SD silver plus skin grafting at 15 d after combined injury and SD zinc alone, the 15-day survival rates were 63%, 69% and 75% respectively, and significantly higher than that of control group (42%). The repair time of burn wound was shorter and the number of white blood cells was lower than that of control. Animals in the group of local use of SD silver followed by skin grafting on the 7th day all died, but all of the animals survived when the skin grafting was performed after 15 days. These results suggested that SD zinc and SD silver showed some therapeutic effects on the combined radiation-burn injury. In critical phase of the combined injury, surgical operation should be prohibited. However, in the recovery phase, skin transplantation could be performed.
Ran
X
X
Department of Preventive Medicines, Third Military Medical College, Chongqing.
Yan
Y
Y
Lin
Y
Y
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000628:therapy*; D003037:Cobalt Radioisotopes; D005260:Female; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000008:administration & dosage*; D016038:Skin Transplantation; D013411:Sulfadiazine / Q000008:administration & dosage*; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage*
D003037:Cobalt Radioisotopes; D013411:Sulfadiazine; D015032:Zinc; D012837:Silver Sulfadiazine