title: Pharmahuasca: human pharmacology of oral DMT plus harmine.
abstract: A summary is presented of human self-experiments or psychonautic bioassays of pharmahuasca--capsules containing crystalline N,N-dimethyltryptamine (DMT) plus harmine, as well as combinations of other psychoactive tryptamines with other beta-carbolines. The 1967 Holmstedt-Lindgren hypothesis of the ayahuasca effect--oral psychoactivity of DMT consequent to monoamine-oxidase (MAO) inhibition from simultaneous ingestion of beta-carbolines--has been confirmed by eight self-experimenters. Results of a total of some 70 bioassays are summarized and the literature on this subject is reviewed (with 66 references and one table).
authors.affiliation: Natural Products Company, Xalapa, Veracruz, México.
authors.forename: J
authors.initials: J
authors.lastname: Ott
mesh_terms: D000284:Administration, Oral; D004338:Drug Combinations; D006247:Harmine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D004130:N,N-Dimethyltryptamine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D006247:Harmine; D004130:N,N-Dimethyltryptamine