title: How good are US studies of HIV costs of care?
abstract: BACKGROUND
  Valid, timely estimates of the costs of HIV care are needed by health planners and policy makers.
  
  
  OBJECTIVE
  To perform a methodologic critique of published estimates of resource utilization and costs of HIV care.
  
  
  METHODS
  MEDLINE database for 1990-1998.
  
  
  METHODS
  Included articles focused on adults with a spectrum of HIV disease in which the authors developed their own resource use and cost data. Thirty one articles met these criteria.
  
  
  METHODS
  Studies were compared based on: (1) utilization and cost estimates, in 1995 dollars; (2) study period; (3) research design; (4) sampling frame; (5) sample size and patient characteristics; (6) data sources and scope of services; and (7) methods used in the analysis.
  
  
  RESULTS
  The most recent estimates pertain to the first half of 1995, before the use of protease inhibitor therapy. We found wide variations in the estimates and identified three major sources for this: (1) patient samples that were restricted to subgroups of the national HIV-infected population; (2) utilization data that were limited in scope (e.g., inpatient care only); and (3) invalid methods for estimating annual or lifetime costs, particularly in dealing with decedents.
  
  
  CONCLUSIONS
  To accurately estimate resource use and costs for HIV care nationwide, a nationally representative probability sample of HIV-infected patients is required. Even in research that is not intended to provide national estimates, the scope of utilization data should be broadened and greater attention to methodologic issues in the analysis of annual and lifetime costs is needed.
authors.affiliation: Department of Veterans Affairs Health Services Research and Development Field Program, Houston, TX 77030, USA. rabeneck@onramp.net
authors.forename: L
authors.initials: L
authors.lastname: Rabeneck
authors.forename: T
authors.initials: T
authors.lastname: Menke
authors.forename: N P
authors.initials: NP
authors.lastname: Wray
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000191:economics; D000328:Adult; D000553:Ambulatory Care / Q000191:economics / Q000706:statistics & numerical data; D017281:Cost of Illness; D015658:HIV Infections / Q000191:economics*; D017048:Health Care Costs / Q000706:statistics & numerical data; D006295:Health Resources / Q000191:economics / Q000706:statistics & numerical data; D006302:Health Services Research / Q000592:standards*; D006801:Humans; D012107:Research Design; D012494:Sampling Studies; D014481:United States