title: Blood pool contrast agent CMD-A2-Gd-DOTA-enhanced MR imaging of infarcted myocardium in pigs.
abstract: The purpose of this study was to assess the ability of the new blood pool contrast agent meglumine-carboxymethyldextran-ethylenediamino-gadoterate (CMD-A2-Gd-DOTA) to depict acute occlusive myocardial infarction (AMI). First-pass gradient-echo and delayed spin-echo magnetic resonance imaging (MRI) was performed 5 days after induction of AMI in a pig model. MRI was correlated with pathology. First-pass imaging with CMD-A2-Gd-DOTA allowed detection of infarcted myocardium in all pigs (n = 7). The infarction was recognized as a black spot on MRI as well as on a parametric image. The signal intensity (SI) amplitudes of normal versus infarcted myocardium were 80.55 +/- 18.61 versus 8.48 +/- 15.50 on MRI and 81.62 +/- 18.50 versus 1.61 +/- 3.73 on the parametric image (both P values < 0.001. The contrast ratio between normal and infarcted myocardium was not significantly improved on spin-echo MRI, suggesting largely intact vascular integrity outside the occluded area. CMD-A2-Gd-DOTA is useful for depicting occlusive myocardial infarction by first-pass MRI. Spin-echo imaging is promising in assessing vascular integrity. J. Magn. Reson. Imaging 1999;10:170-177.
authors.affiliation: Department of Radiology, C2-S, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Kroft
authors.forename: J
authors.initials: J
authors.lastname: Doornbos
authors.forename: R J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005682:Gadolinium / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds / Q000008:administration & dosage; D013552:Swine
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C107329:carboxymethyl-dextran-A2-gadolinium-DOTA; D005682:Gadolinium