title: Diagnosis and tumor response in osteosarcoma and Ewing's sarcoma, according to treatment protocols SSG II, SSG VIII, ISG/SSG I, SSG IV and SSG IX.
abstract: 114 patients with osteosarcoma in the extremities had been reported to the SSG II trial, 132 to the SSG VIII trial and, until October 1998, 99 to the ISG/SSG I trial. The SSG IV trial included 53 patients and the SSG IX trial 104 patients until October 1998. In the SSG II trial, 19% were good responders (grades III and IV) as compared to 51% in the SSG VIII trial. On reevaluation was the response changed in one forth of the cases in both the SSG II and SSG VIII trials. In 9 and 10 cases (8%), respectively, the reevaluation resulted in a change from "good responder" to "bad responder". In the ISG/SSG I trial, the preliminary results showed a good response in 22% of the cases. In the SSG IV trial, 44% were good responders (grades III and IV), as compared to 54% in the SSG IX trial.
authors.affiliation: Dept. of Pathology, University of Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Holmström
authors.forename: T
authors.initials: T
authors.lastname: Böhling
authors.forename: M
authors.initials: M
authors.lastname: Akerman
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: E
authors.initials: E
authors.lastname: Stenwig
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002985:Clinical Protocols; D006801:Humans; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D012042:Registries; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery*; D012537:Scandinavian and Nordic Countries; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents