title: Implication of HLA-DMA alleles in corsican IDDM.
abstract: The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and IDDM, in a Corsican population. The DMA*0101 allele was observed to confer a significant predisposition to this autoimmune disease while the DMA*0102 allele protected significantly. Experiments examining polymorphism of the HLA-DRB1 gene established that these relationships are not a consequence of linkage disequilibrium with HLA-DRB1 alleles implicated in this pathology. The study of the DMA gene could therefore be an additional tool for early IDDM diagnosis in the Corsican population.
authors.affiliation: CEVAREN, Université de Corse, Corte, France. maury@univ-corse.fr
authors.forename: P
authors.initials: P
authors.lastname: Cucchi-Mouillot
authors.forename: S
authors.initials: S
authors.lastname: Lai
authors.forename: C
authors.initials: C
authors.lastname: Carcassi
authors.forename: P
authors.initials: P
authors.lastname: Sorba
authors.forename: M
authors.initials: M
authors.lastname: Stuart-Simoni
authors.forename: J P
authors.initials: JP
authors.lastname: Amoros
authors.forename: B
authors.initials: B
authors.lastname: Genetet
authors.forename: D
authors.initials: D
authors.lastname: Haras
authors.forename: L
authors.initials: L
authors.lastname: Contu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005602:France; D005787:Gene Frequency; D005819:Genetic Markers; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II