title: No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese.
abstract: The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.
authors.affiliation: Department of Neurology, China Medical College Hospital, Taiwan.
authors.forename: C J
authors.initials: CJ
authors.lastname: Hu
authors.forename: S M
authors.initials: SM
authors.lastname: Sung
authors.forename: H C
authors.initials: HC
authors.lastname: Liu
authors.forename: K Y
authors.initials: KY
authors.lastname: Lee
authors.forename: W C
authors.initials: WC
authors.lastname: Hsu
authors.forename: W K
authors.initials: WK
authors.lastname: Wong
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Tsai
authors.forename: J G
authors.initials: JG
authors.lastname: Chang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D013624:Taiwan; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D000511:alpha-Macroglobulins