title: An acetylsalicylic acid-sensitive aggregation phenomenon in Dipodascopsis uninucleata.
abstract: Aggregation of ascospores has been discovered in the yeast Dipodascopsis uninucleata. When this yeast is cultivated to reach the sexual reproductive stage, small ascospores are individually released from the tip of a sac-like ascus which then aggregate in orderly clusters. Acetylsalicylic acid (ASA) inhibited ascospore release and subsequent ordered aggregation process. We suggest that novel ASA-sensitive oxidised fatty acids (3R-hydroxy-oxylipins) and small hooks located on the surface of these ascospores, are involved.
authors.affiliation: Department of Microbiology and Biochemistry, University of the Orange Free State, South Africa. Kockjlf@micro.nw.uovs.ac.za
authors.forename: J L
authors.initials: JL
authors.lastname: Kock
authors.forename: P W
authors.initials: PW
authors.lastname: van Wyk
authors.forename: P
authors.initials: P
authors.lastname: Venter
authors.forename: D J
authors.initials: DJ
authors.lastname: Coetzee
authors.forename: D P
authors.initials: DP
authors.lastname: Smith
authors.forename: B C
authors.initials: BC
authors.lastname: Viljoen
authors.forename: S
authors.initials: S
authors.lastname: Nigam
mesh_terms: D001203:Ascomycota / Q000187:drug effects / Q000502:physiology*; D001241:Aspirin / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology; D013172:Spores, Fungal / Q000187:drug effects / Q000502:physiology
chemical_list: D005227:Fatty Acids; D001241:Aspirin