Hydroxylamine blocks pre- but not postsynaptic adenosine A(1) receptor-mediated actions in rat hippocampus.
The commonly used nitric oxide donor, hydroxylamine (NH(2)OH), can block or reverse the inhibition of glutamatergic transmission by adenosine or an adenosine A(1) agonist in rat hippocampal slice. In these experiments, hydroxylamine did not affect the adenosine A(1) receptor-mediated depression of postsynaptic excitability. We conclude that hydroxylamine acts presynaptically to counter adenosine A(1) receptor-mediated inhibition of synaptic transmission.
Fowler
J C
JC
Department of Physiology, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th Street, Lubbock, TX 79430, USA. phyjcf@ttuhsc.edu
Gervitz
L
L
Partridge
L D
LD
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D019811:Hydroxylamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D020030:Nitric Oxide Donors / Q000494:pharmacology; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology; D058915:Purinergic P1 Receptor Antagonists; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D020030:Nitric Oxide Donors; D058915:Purinergic P1 Receptor Antagonists; D011810:Quinoxalines; D018047:Receptors, Purinergic P1; D019811:Hydroxylamine; C027513:N(6)-cyclohexyladenosine; C056723:FG 9041; D008274:Magnesium; D000241:Adenosine; D002118:Calcium