[The adverse effects of the water-soluble iodinated contrast media used in excretory urography in the canine species].
In five dogs with normal renal function, doses of 200, 400, 600 and 800 mg of iodine/kg bodyweight of iohexol (350 mg of iodine/ml) were assessed in comparison to a dose of 880 mg of iodine/kg bodyweight of meglumine-sodium amidotrizoate (370 mg of iodine/ml) to determine the hematologic and biochemical parameters, urinalysis and urinary osmolality, pulse and respiratory rates, and adverse effects were determined. The such clinical secondary effects as tachycardia, muscular contractions and tremors took place in the animals with the contrast Iohexol, these were transitory and without vital repercussion. There was no significant difference between groups and times in any of the biochemical and hematological parameters analyzed. A decrease in urine creatinine was observed on Amidotrizoate group 24 hours after administration of the contrast agent while an increased was observed on Iohexol 600 mg of iodine/kg in that time.
Hita Rosino
E
E
Servicio de Urología, Hospital de La Inmaculada, Huercal-Overa, Almería.
Agut Giménez
A
A
Sánchez-Valverde García
M A
MA
D000818:Animals; D001769:Blood / Q000187:drug effects; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D012995:Solubility; D013997:Time Factors; D014567:Urography / Q000379:methods / Q000706:statistics & numerical data
D003287:Contrast Media; D003973:Diatrizoate; D007472:Iohexol
Efectos secundarios de los medios de contraste iodados hidrosolubles utilizados en la urografía excretora en la especie canina.