[The effect of live tularemia vaccination on the short- and long-term results of combined therapy of patients with endometrial cancer].
A randomized investigation of the immediate (wound healing) and end-results (relapse and metastasis frequency, recurrence-free period, 2-, 3- or 5-year survival, lethality rate and mean lifespan) of combined (surgery + distant gamma-therapy) treatment of two groups of patients with endometrial carcinoma was carried out. The study group was operated on days 15-20 after immunization with tularemia live vaccine (TLV) while the controls were had no preliminary immunization. It was shown that all indices of the immediate and end-results of treatment were significantly better in the study group for all stages. It is concluded that TLV immunization given 15-20 days before surgery is followed by a lower frequency of postoperative complications and better end-results.
Adamian
R T
RT
V.A.Fanarjan Center for Cancer Research, Ministry of Health of the Republic of Armenia, Yerevan.
Movsesian
M A
MA
D001428:Bacterial Vaccines / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D014406:Tularemia / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000627:therapeutic use
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated
Vliianie tuliaremiĭnoĭ zhivoĭ vaktsiny na blizhaĭshie i otdalënnye rezul'taty kombinirovannogo lecheniia bol'nykh rakom tela matki.