A novel method of endoscopic mucosal resection using sodium hyaluronate.
BACKGROUND
Saline-assisted endoscopic mucosal resection is an established therapeutic method. However, it is sometimes difficult to maintain a desired level of tissue elevation after injection of saline. Therefore we decided to use a mucinous substance such as sodium hyaluronate instead of saline.


METHODS
Two resected porcine stomachs and five dogs were used for the study. The elevations, made by submucosal injections of sodium hyaluronate, were compared with those produced with normal saline. Sodium hyaluronate-assisted mucosal resections were compared with the saline-assisted resections.


RESULTS
Mucosal elevations created by submucosal injections of sodium hyaluronate remained for a longer time with a clearer margin compared to those made by saline injection. Endoscopic mucosal resections were performed safely with the assistance of sodium hyaluronate.


CONCLUSIONS
Use of sodium hyaluronate instead of saline for endoscopic mucosal resection could make the procedure easier and more reliable.
Yamamoto
H
H
Department of Gastroenterology, Jichi Medical School, Tochigi, Japan.
Yube
T
T
Isoda
N
N
Sato
Y
Y
Sekine
Y
Y
Higashizawa
T
T
Ido
K
K
Kimura
K
K
Kanai
N
N
D000818:Animals; D004285:Dogs; D004724:Endoscopy / Q000379:methods*; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D006820:Hyaluronic Acid / Q000494:pharmacology*; D007267:Injections; D009336:Necrosis; D011127:Polyps / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery; D012965:Sodium Chloride / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery; D013552:Swine; D016896:Treatment Outcome
D012965:Sodium Chloride; D006820:Hyaluronic Acid