Pancreatitis associated with Crohn's disease: a premalignant state for cystadenocarcinoma of pancreas?
We report a 74-yr-old woman with Crohn's disease and acute pancreatitis who, 3 yr after resolution of the latter, developed cystadenocarcinoma of the pancreas. No drug, toxin, or other etiologies including contiguous duodenal involvement were identified as responsible for the pancreatitis, suggesting that pancreatitis was an extraintestinal manifestation of her Crohn's disease. Could Crohn's-associated pancreatitis be a premalignant state for cystadenocarcinoma of the pancreas?
Gotian
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A
Department of Medicine, North Shore University Hospital, Manhasset, New York, USA.
Katz
S
S
D000208:Acute Disease; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003424:Crohn Disease / Q000473:pathology*; D003536:Cystadenocarcinoma / Q000473:pathology*; D003537:Cystadenoma / Q000473:pathology; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology*; D010195:Pancreatitis / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*