Continuous microinstillation of phenol red on liver surface for liver site-selective delivery.
We report a very promising approach for liver site-selective drug delivery through drug instillation on liver surface. Phenol red, which was selected as a model drug, was accumulated in the instillation site after instillation on the rat liver surface. The site-selective localization was enhanced by gradually and continuously instilling a small amount of drug solution on the liver surface.
Nakamura
J
J
School of Pharmaceutical Sciences, Nagasaki University, Japan.
Yoshida
Y
Y
Mera
K
K
Mukai
T
T
Nishida
K
K
Sasaki
H
H
D000818:Animals; D016503:Drug Delivery Systems; D066298:In Vitro Techniques; D007202:Indicators and Reagents / Q000008:administration & dosage / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D010637:Phenolsulfonphthalein / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
D007202:Indicators and Reagents; D010637:Phenolsulfonphthalein