title: Venous thromboembolism occurs frequently in patients undergoing brain tumor surgery despite prophylaxis.
abstract: Most Neurosurgical Service patients at our hospital receive venous thromboembolism prophylaxis. In 1995-96, the rate of clinically overt venous thromboembolism was 3.7% among patients undergoing neurosurgery. However, rates were much higher when craniotomy was undertaken for brain tumor. Of 497 who underwent craniotomy for primary (429) or metastatic (68) brain tumor, 47 (9.5%) developed clinically overt venous thromboembolism: 7.5% after primary brain tumor resection and 19% after craniotomy for metastatic cancer. The high rate of venous thromboembolism in craniotomy patients with brain tumor warrants study of alternative measures for preventing thrombus, such as prophylaxis with low molecular weight heparin.
authors.affiliation: Cardiovascular and Neurosurgical Divisions, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Atiemo
authors.forename: L K
authors.initials: LK
authors.lastname: Diran
authors.forename: G P
authors.initials: GP
authors.lastname: Licholai
authors.forename: P
authors.initials: P
authors.lastname: McLaren Black
authors.forename: M A
authors.initials: MA
authors.lastname: Creager
authors.forename: S Z
authors.initials: SZ
authors.lastname: Goldhaber
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D020246:Venous Thrombosis / Q000209:etiology* / Q000517:prevention & control
chemical_list: D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight