title: No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
abstract: Recent genome screening studies have identified novel regions of possible interest for susceptibility to type 1 diabetes. One of these is a 30-35 cM region mapping to 16q22-q24 (D16S515-D16S520), where also the gene encoding NAD(P)H: quinone oxidoreductase (NQO1) maps. Data has suggested association of a polymorphism (P187S) in the NQO1 gene and type 1 diabetes. NQO1 is involved in protection against oxidative stress, which is likely to be involved in beta-cell destruction. By use of the transmission disequilibrium test (TDT), we analyzed the P187S polymorphism for association to type 1 diabetes in a population-based sample of 247 Danish nuclear type 1 diabetic families. Random transmission patterns were observed to all affected offspring (p(tdt) = 0.82), to index cases (P(tdt) = 0.77), as well as to unaffected offspring (P(tdt) = 0.93). Hence, the NQO1 polymorphism is not likely to be an etiological mutation underlying the reported linkage of the 16q22-q24 region.
authors.affiliation: Steno Diabetes Center, Gentofte, Denmark.
authors.forename: O P
authors.initials: OP
authors.lastname: Kristiansen
authors.forename: Z M
authors.initials: ZM
authors.lastname: Larsen
authors.forename: J
authors.initials: J
authors.lastname: Johannesen
authors.forename: J
authors.initials: J
authors.lastname: Nerup
authors.forename: T
authors.initials: T
authors.lastname: Mandrup-Poulsen
authors.forename: F
authors.initials: F
authors.lastname: Pociot
mesh_terms: D002885:Chromosomes, Human, Pair 16; D003718:Denmark; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone)