title: The human selenium status in 27 regions of Russia.
abstract: Russia is the largest nation in the world and it has vastly different climatic and geochemical conditions. The human selenium status is determined mainly by the selenium intake from foods, whose concentration is subject to geochemical, geological and temporal factors. The data on the selenium status of populations in Russia are scarce and sporadic. This review presents the most recent selenium data acquired using adequate quality assurance measures. Serum samples were obtained from 2462 healthy blood donors between 1990-1996 from 125 locations representing 27 different regions of Russia. Samples of wheat flour and dried milk were also analyzed from most regions. The mean serum selenium concentration per region varied from 0.80 mumol/l in the western regions (Pskov) to 1.84 mumol/l in the easternmost regions (Sakhalin). A low (0.76-1.00 mumol/l) serum selenium concentration was found in only 6% of the locations. In 88% of the locations the mean serum selenium concentrations were moderate (1.01-1.40 mumol/l) and the highest values, > 1.45 mumol/l were found in eight towns. Wheat flour selenium concentrations varied widely from 44 to 557 micrograms/kg depending on the origin. The low values were either domestic or European and the high values of American or Australian origin. A high correlation between serum selenium and wheat flour (r = 0.79) suggests that the selenium status in most instances is determined by high selenium in wheat. Overtly very low or high serum selenium levels were not found in the 27 regions studied in Russia.
authors.affiliation: Department of Toxicology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: N A
authors.initials: NA
authors.lastname: Golubkina
authors.forename: G V
authors.initials: GV
authors.lastname: Alfthan
mesh_terms: D000328:Adult; D000818:Animals; D001782:Blood Donors; D004032:Diet; D005260:Female; D005433:Flour / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000737:chemistry; D009752:Nutritional Status; D011786:Quality Control; D012016:Reference Values; D012426:Russia; D012643:Selenium / Q000032:analysis / Q000097:blood*; D014908:Triticum / Q000737:chemistry
chemical_list: D012643:Selenium