New NO donors with antithrombotic and vasodilating activities. Part 22. Nitrosation products of hexamethylenetetramine.
Two nitrosation products of hexamethylenetetramine, namely 1,3,5-trinitrosohexahydro-1,3,5-triazine (1) and 3,7-dinitroso- 1,3,5,7-tetrazabicyclo[3.3.1]nonane (2), were synthesized. It is shown that both compounds in vitro at 37 degrees C (1 h, pH 7.4) form nitric oxide at a rate of 3.1% (1) or 1.3% (2), respectively. In rats (60 mg/kg p.o.) both compound inhibit thrombus formation in arterioles (1: 20%; 2: 16%) and venules (1: 18%; 2: 9%). Compound 2 does not influence the blood pressure in spontaneously hypertensive rats.
Herpel
M
M
Institut für Pharmazie I, Freie Universität Berlin, Germany.
Rehse
K
K
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents; D020030:Nitric Oxide Donors