title: Confirmation of N-(nitrosomethyl) urea as a nitrosourea derived by nitrosation of fish sauce.
abstract: N-(nitrosomethyl) urea (NMU) was characterized in the carcinogenic nitrosated fish sauce (NFS) with high performance liquid chromatography (HPLC)-photohydrolysis-pyrolysis-thermal energy analysis recently. We used HPLC-electronic spray ionization-mass spectrometry and HPLC-diode array detection to confirm NMU in NFS further. It was observed that the corresponding chromatographic fraction of NMU of NFS showed the same mass spectrum (m/z 64, 102, and 145) and ultraviolet-absorbance (lambda max = 230 nm) as those of authentic NMU. These results confirmed that the component of NFS was NMU.
authors.affiliation: Beijing Institute for Cancer Research & Beijing Medical University School of Oncology, China.
authors.forename: D J
authors.initials: DJ
authors.lastname: Deng
authors.forename: S M
authors.initials: SM
authors.lastname: Yang
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: H J
authors.initials: HJ
authors.lastname: Xin
mesh_terms: D002273:Carcinogens / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D005396:Fish Products / Q000032:analysis*; D013058:Mass Spectrometry; D008770:Methylnitrosourea / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002273:Carcinogens; D008770:Methylnitrosourea