Overview of frontotemporal dementias and the consensus applied.
Frontotemporal dementia, progressive nonfluent aphasia and semantic dementia are distinct clinical syndromes arising from degeneration of the frontotemporal lobes, each syndrome being determined by the distribution of degenerative change within the brain. The Lund-Manchester consensus statement provided diagnostic guidelines for frontotemporal dementia, which were devised to improve its clinical and pathological recognition. The Lund-Manchester groups together with researchers from the United States, Canada and Europe have sought to build on those original criteria to produce a revised set of consensus criteria for each of the major clinical syndromes of frontotemporal lobe degeneration. It is hoped that these new criteria will serve to highlight an important and neglected form of dementia and provide the impetus for clinical and basic scientific research.
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Department of Neurology, Manchester Royal Infirmary, Manchester, UK. dneary@fs1.cmht.nwest.nhs.uk
D003704:Dementia / Q000145:classification / Q000523:psychology*; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D013702:Temporal Lobe / Q000503:physiopathology*