A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl.
OBJECTIVE
To report a rare case of gonadotroph adenoma accompanied by ovarian enlargement in a child.


METHODS
Case report.


METHODS
A university hospital.


METHODS
A 10-year-old Japanese girl with multiple cysts of both ovaries.


METHODS
Endocrinologic assays, immunohistochemical staining, ultrastructural observations, and in vitro analysis.


METHODS
The endocrinologic assays showed an elevated serum FSH level. The tumor cells excised from the gonadotroph adenoma were immunohistochemically positive for antihuman FSH monoclonal antibody. When cultured in vitro, the tumor cells secreted FSH in the primary culture.


RESULTS
The gonadotroph adenoma produced FSH. After transsphenoidal surgery, both ovaries decreased in size.


CONCLUSIONS
The ovarian enlargement was induced by endogenous FSH from the gonadotroph adenoma. To our knowledge, this is the first reported case of gonadotroph adenoma accompanied by ovarian enlargement in childhood or adolescence.
Tashiro
H
H
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Kumamoto-City, Japan. obgyn@kaiju.medic.kumamoto-u.ac.jp
Katabuchi
H
H
Ohtake
H
H
Kaku
T
T
Ushio
Y
Y
Okamura
H
H
D000236:Adenoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D017077:Culture Media, Conditioned / Q000737:chemistry; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D010048:Ovarian Cysts / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D017077:Culture Media, Conditioned; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone