Alcohol intake and brain [3H]muscimol binding sites in alcohol-preferring and non-preferring rats.
The present study has employed in vitro autoradiography to determine the distribution and density of [3H]muscimol binding sites in the brains of alcohol high-preferring line of rats (WHP) and alcohol low-preferring line of rats (WLP). While the density of [3H]muscimol binding was found to be similar in the frontal cortex, caudate-putamen, nucleus accumbens, lateral and medial septum, the density of [3H]muscimol binding was lower in cingulate cortex of alcohol low-preferring rats as compared to alcohol high preferring rats. Moreover, the density of muscimol binding sites within this area was positively correlated with the intensity of ethanol consumption.
Dyr
W
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Siemiatkowski
M
M
Płaźnik
A
A
Bidziński
A
A
Kostowski
W
W
D000428:Alcohol Drinking / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D018755:GABA Agonists / Q000378:metabolism*; D058785:GABA-A Receptor Agonists; D009118:Muscimol / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D012641:Selection, Genetic
D018755:GABA Agonists; D058785:GABA-A Receptor Agonists; D011963:Receptors, GABA-A; D009118:Muscimol; D000431:Ethanol