title: Retrieval and analysis of particulate debris after saphenous vein graft intervention.
abstract: OBJECTIVE
  This study was designed to evaluate the composition and quantity of particulate debris resulting from vein graft intervention.
  
  
  BACKGROUND
  Distal embolization and "no reflow" are frequent and important complications resulting from angioplasty of diseased saphenous vein grafts. Little is known about the composition and quantity of embolic particulate debris associated with vein graft intervention, and no intervention has been shown to protect against its clinical consequences.
  
  
  METHODS
  A catheter system, designed to contain, retrieve and protect against distal embolization of this material, was evaluated during 27 percutaneous interventional saphenous vein graft procedures. Clinical, angiographic and pathologic analyses were performed.
  
  
  RESULTS
  The duration of distal graft occlusion required to allow intervention and subsequent debris removal was 150 +/- 54 s, decreasing as experience was gained. Thrombolysis in Myocardial Infarction trial (TIMI) flow grade increased from 2.6 +/- 0.8 to 3.0 +/- 0.0. Creatine kinase (CK) rose above normal in three patients (11.1%) exceeding 3x normal in one (3.7%) resulting in the diagnosis of non-Q-myocardial infarction. Particulate material was identified following 21 of 23 procedures suitable for analysis. Particle size was 204 +/- 57 microm in the major axis and 83 +/- 22 microm in the minor axis. Particles consisted predominantly of soft acellular atheromatous material, such as that typically found under a fibrous cap. Semiquantitative analysis suggested that the quantity of particulate material was less following stenting than following balloon dilation.
  
  
  CONCLUSIONS
  Particulate matter is commonly present following routine angioplasty and stenting of saphenous vein grafts. Containment, retrieval and analysis of this particulate debris are all feasible. Comparison to prior clinical experience is limited by small sample size. However, to the extent that these particles may contribute to distal embolization, no-reflow and infarction, such a system may contribute to the reduction of complications following vein graft intervention.
authors.affiliation: St. Paul's Hospital, University of British Columbia, Vancouver, Canada. johnwebb@bc.sympatico.ca
authors.forename: J G
authors.initials: JG
authors.lastname: Webb
authors.forename: R G
authors.initials: RG
authors.lastname: Carere
authors.forename: R
authors.initials: R
authors.lastname: Virmani
authors.forename: D
authors.initials: D
authors.lastname: Baim
authors.forename: P S
authors.initials: PS
authors.lastname: Teirstein
authors.forename: P
authors.initials: P
authors.lastname: Whitlow
authors.forename: C
authors.initials: C
authors.lastname: McQueen
authors.forename: F D
authors.initials: FD
authors.lastname: Kolodgie
authors.forename: E
authors.initials: E
authors.lastname: Buller
authors.forename: A
authors.initials: A
authors.lastname: Dodek
authors.forename: G B
authors.initials: GB
authors.lastname: Mancini
authors.forename: S
authors.initials: S
authors.lastname: Oesterle
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D001161:Arteriosclerosis / Q000473:pathology; D002404:Catheterization; D001026:Coronary Artery Bypass; D004617:Embolism / Q000473:pathology; D005260:Female; D006083:Graft Occlusion, Vascular / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000473:pathology / Q000637:transplantation*; D015607:Stents; D013396:Suction