[Interleukin-13 in the nasal lavage of pollinosis patients after specific intranasal challenge].
The unique properties of interleukin-13 have drawn the attention of investigators to its role in atopic diseases and in the mechanism of specific immunotherapy. The aim of this paper was to determine whether the presence of interleukin-13 will, apart from interleukina-4, be found in the nasal lavage after specific challenge and if the levels of these cytokines will differ. The studies included 13 patients in whom grass and rye pollen allergy was confirmed by the case history, skin tests and the presence of specific IgE in the blood serum. In all these persons active anterior rhinomanometry and than specific challenge with gradually increasing concentrations of the grass pollen allergen were performed before the season. At the end of these challenge, nasal lavage was done and the lavage fluid was preparated for determination of IL-4 and IL-13. Both cytokines were found to be present in the nasal lavage and in 6 patients the IL-13 concentration was higher than that of IL-4. Three of these patients had been previously hyposensitized. Although the results presented here are preliminary, they may provide inspiration four further investigations of the role of IL-13 in the specific immunotherapy in pollinosis patients.
Rogalewska
A
A
Kliniki Alergologii, Akademii Medycznej w Białymstoku.
Michalska
I
I
Michno
T
T
Chyrek-Borowska
S
S
D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007167:Immunotherapy; D018793:Interleukin-13 / Q000032:analysis / Q000276:immunology; D020382:Interleukin-18 / Q000032:analysis* / Q000276:immunology*; D015847:Interleukin-4 / Q000032:analysis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009298:Nasal Polyps / Q000276:immunology* / Q000628:therapy*; D009299:Nasal Provocation Tests; D012882:Skin Tests
D018793:Interleukin-13; D020382:Interleukin-18; D015847:Interleukin-4; D007073:Immunoglobulin E
Interleukina-13 w popłuczynach nosa chorych na pyłkowice po swoistej prowokacji donosowej.