title: Treatment of aregeneratoric anemia following an ABO-incompatible allogeneic peripheral blood stem cell transplantation: a case report.
abstract: Aregeneratoric anemia (AA) occurs rarely after ABO-incompatible allogeneic peripheral blood stem cell transplantation (alloPBSCT), and its management is generally difficult. Here, we present a 31-year-old white man with myelodysplastic syndrome who developed AA after receiving stem cells from his human leukocyte antigen (HLA) identical, but ABO-incompatible sibling. Because his anti-A antibody titers were high, therapy with conventional doses of erythropoietin and prednisolone failed to treat the AA. Following 8 cycles of plasma exchange and higher doses of erythropoietin and prednisolone as well as danazol administration, anti-A titers decreased, and his anemia improved significantly. In conclusion, to treat and obtain a low titer of antibodies in a patient with AA following an ABO-incompatible alloPBSCT, higher doses of erythopoietin and corticosteroids associated with plasma exchange have to be used.
authors.affiliation: Department of Hematology/Oncology, Ibn-i Sina Hospital, Medical School, Ankara University, Turkey. ustun@dialup.ankara.edu.tr
authors.forename: C
authors.initials: C
authors.lastname: Ustün
authors.forename: H
authors.initials: H
authors.lastname: Celebi
authors.forename: M
authors.initials: M
authors.lastname: Arat
authors.forename: M
authors.initials: M
authors.lastname: Ozcan
authors.forename: I
authors.initials: I
authors.lastname: Dilek
authors.forename: G
authors.initials: G
authors.lastname: Gürman
authors.forename: T
authors.initials: T
authors.lastname: Demirer
authors.forename: O
authors.initials: O
authors.lastname: Ilhan
authors.forename: R
authors.initials: R
authors.lastname: Keskin
authors.forename: H
authors.initials: H
authors.lastname: Koç
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001787:Blood Group Incompatibility; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D010951:Plasma Exchange; D011239:Prednisolone / Q000627:therapeutic use; D012010:Red-Cell Aplasia, Pure / Q000628:therapy*
chemical_list: D000017:ABO Blood-Group System; D000893:Anti-Inflammatory Agents; D011239:Prednisolone