Intestinal amoebiasis, giardiasis and geohelminthiases: their association with other intestinal parasites and reported intestinal symptoms.
In order to determine reported signs and symptoms that may predict an intestinal parasitic infection, 241 schoolchildren in western Côte d'Ivoire were interviewed with a simple questionnaire and their stool specimens were examined over several consecutive days. Special emphasis was placed on (i) assessing infections by Entamoeba histolytica/E. dispar, Giardia duodenalis and by intestinal worms, (ii) looking for associations between these parasites, and (iii) looking for associations between these parasites and commonly perceived intestinal signs and symptoms. Complete questionnaire results, intestinal helminth infections derived from 4 Kato-Katz thick smears, and intestinal protozoa infections assessed on a single day by a formalin-ether concentration procedure were obtained from 209 children (87%). A logistic regression modelling approach showed that an infection with E. histolytica/E. dispar was significantly associated with an Entamoeba coli infection. However, for G. duodenalis, hookworm and Ascaris lumbricoides, no association was found between any of these parasites and other intestinal parasites. In a multivariate analysis reported diarrhoea was the only symptom positively associated with an E. histolytica/E. dispar infection (P = 0.028). Its diagnostic performance showed a low sensitivity (28%), a high specificity (85%) and moderate positive and negative predictive values (52% and 67%, respectively). Surprisingly, reported 'turning stomach' was less often reported by children infected with G. duodenalis (borderline significance, P = 0.057). It is concluded that reported diarrhoea could be a symptom worth exploring further for the rapid identification of schoolchildren infected with E. histolytica/E. dispar.
Utzinger
J
J
Swiss Tropical Institute, Department of Public Health and Epidemiology, Basle, Switzerland.
N'Goran
E K
EK
Marti
H P
HP
Tanner
M
M
Lengeler
C
C
D000293:Adolescent; D000704:Analysis of Variance; D000818:Animals; D002648:Child; D007560:Cote d'Ivoire; D004404:Dysentery, Amebic / Q000150:complications* / Q000175:diagnosis; D056890:Eukaryota / Q000302:isolation & purification; D005243:Feces / Q000469:parasitology; D005260:Female; D017144:Focus Groups; D005873:Giardiasis / Q000150:complications* / Q000175:diagnosis; D006373:Helminthiasis / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000150:complications*; D008297:Male; D012680:Sensitivity and Specificity