Lipotransin: a novel docking protein for hormone-sensitive lipase.
Lipotransin is a novel hormone-sensitive lipase (HSL)-interacting protein that appears to translocate HSL to the lipid droplet. The interaction of the two proteins depends upon the phosphorylation of HSL by protein kinase A. Once formed, the complex is dissociated by ATP hydrolysis, due to the ATPase activity of lipotransin. In 3T3L1 adipocytes, insulin produces a stable complex between the proteins, due to a modification of lipotransin. Thus, lipotransin is a novel docking protein that may direct the hormonally regulated redistribution of hormone-sensitive lipase.
Syu
L J
LJ
Department of Physiology, University of Michigan School of Medicine, Ann Arbor 49109, USA.
Saltiel
A R
AR
D016475:3T3 Cells; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D005786:Gene Expression Regulation; D007328:Insulin / Q000494:pharmacology; D008066:Lipolysis; D051379:Mice; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics; D002787:Sterol Esterase / Q000235:genetics / Q000378:metabolism*
D002352:Carrier Proteins; D007328:Insulin; D012333:RNA, Messenger; D000255:Adenosine Triphosphate; D017868:Cyclic AMP-Dependent Protein Kinases; D002787:Sterol Esterase