title: Healing of chronic leg ulcers in diabetic necrobiosis lipoidica with local granulocyte-macrophage colony stimulating factor treatment.
abstract: Two young insulin-dependent diabetic patients suffering from chronic nonhealing leg ulcers of necrobiosis lipoidica diabeticorum were treated by applying topically recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) on the ulcer repetitively during 10 weeks. Evaluation of ulcer size was assessed with clinical examinations at 1-week or 2-week intervals. Topical GM-CSF healed the ulcers of both patients in 10 weeks. Decrease in the size of the ulcers was already evident after the first topical applications. During follow-up, the ulcers have remained healed for more than 3 years. This excellent treatment result suggests that topically applied GM-CSF may be a valuable drug for chronic, nonhealing ulcers in patients with diabetes.
authors.affiliation: Turku University Central Hospital, Department of Medicine, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Remes
authors.forename: T
authors.initials: T
authors.lastname: Rönnemaa
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D009335:Necrobiosis Lipoidica / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D016178:Granulocyte-Macrophage Colony-Stimulating Factor