Evaluation of the neurovirulence test for mumps vaccines.
Neurovirulence tests in Macaca fascicularis using commercial preparations of different vaccine bulks and a wild-type strain revealed that the test was unable to distinguish mixed from pure populations or a suitable vaccine from a related strain which has been shown to be associated with clinical meningitis. However, the test was able to distinguish a wild-type strain from the vaccine strains successfully. The ability of the test to discriminate between acceptable and unacceptable seeds requires further examination.
Afzal
M A
MA
Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, U.K. mafzal@nibsc.ac.uk
Marsden
S A
SA
Hull
R M
RM
Pipkin
P A
PA
Bentley
M L
ML
Minor
P D
PD
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology / Q000821:virology; D002552:Cerebral Ventricles / Q000473:pathology / Q000821:virology; D002522:Chlorocebus aethiops; D006801:Humans; D008252:Macaca fascicularis; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000592:standards*; D009109:Mumps virus / Q000472:pathogenicity; D012698:Serologic Tests; D012720:Severity of Illness Index; D014709:Vero Cells; D014774:Virulence
D009108:Mumps Vaccine