title: Effects of hypocaloric dietary treatment enriched in oleic acid on LDL and HDL subclass distribution in mildly obese women.
abstract: OBJECTIVE
  To study the effects of a carbohydrate-enriched (HiCarbo) or olive-oil-enriched (HiMUFA) hypocaloric diet on plasma lipoprotein levels and physical properties.
  
  
  METHODS
  A six-month follow-up dietary intervention study with a HiCarbo diet providing 60% of total calories as complex carbohydrates, 15% as proteins and 25% as fats [10% saturated (SFA); 7% monounsaturated (MUFA); 8% polyunsaturated fatty acids (PUFA)]; or a HiMUFA diet with 40% complex carbohydrates, 15% proteins and 45% fats (10% SFA; 27% MUFA; 8% PUFA).
  
  
  METHODS
  Twenty consecutive, mildly obese, normolipidemic premenopausal women (11 on HiCarbo and nine on HiMUFA diets) and 14 age- and sex-matched, lean controls.
  
  
  METHODS
  Body mass index (BMI), waist/hip ratio, plasma lipoproteins, apolipoprotein (apo) AI and B, LDL and HDL density distribution, and phospholipid fatty acid composition at baseline, and after 3 and 6 months on dietary treatment.
  
  
  RESULTS
  Body weight progressively decreased during the first 3 months and then it stabilized during the following 3 months (-11% vs. baseline in both groups; P < 0.01). LDL-Cholesterol decreased significantly in both groups. HDL-Cholesterol increased significantly in the HiMUFA group, whereas a decreased level was observed in the HiCarbo group. At baseline the obese women had higher very low density lipoprotein (VLDL) and dense LDL-Cholesterol, and lower HDL2 cholesterol levels than the controls; these abnormalities persisted in the HiCarbo diet, whilst a significant decrease in the dense LDL associated with an increase in the HDL2 cholesterol was seen in the HiMUFA diet. HDL3 was not affected by either diet. The LDL/HDL-Cholesterol ratio was not affected by the HiCarbo diet, whilst it was significantly reduced after 6 months of HiMUFA diet as compared with baseline. Apo AI increased in the HiMUFA group, and decreased in the HiCarbo group.
  
  
  CONCLUSIONS
  Both diets were effective in decreasing body weight. At steady weight conditions, only the HiMUFA diet improved LDL and HDL subclass distribution abnormalities present in mildly obese normolipidemic women.
authors.affiliation: Institute of Internal Medicine, University of Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zambon
authors.forename: G
authors.initials: G
authors.lastname: Sartore
authors.forename: D
authors.initials: D
authors.lastname: Passera
authors.forename: F
authors.initials: F
authors.lastname: Francini-Pesenti
authors.forename: A
authors.initials: A
authors.lastname: Bassi
authors.forename: C
authors.initials: C
authors.lastname: Basso
authors.forename: S
authors.initials: S
authors.lastname: Zambon
authors.forename: E
authors.initials: E
authors.lastname: Manzato
authors.forename: G
authors.initials: G
authors.lastname: Crepaldi
mesh_terms: D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004038:Diet, Reducing; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000473:pathology; D019301:Oleic Acid / Q000008:administration & dosage*; D010743:Phospholipids / Q000097:blood; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D010743:Phospholipids; D014280:Triglycerides; D019301:Oleic Acid