title: [Porokeratosis Mibelli gigantea: case report and literature review].
abstract: Porokeratos of Mibelli is a rare inherited disorder of epidermal keratinization, whose pathogenesis is not fully understood. The common clinical feature is a erythematous plaque surrounded by a hyperkeratotic border. The histopathologic hallmark is a parakeratotic cornoid lamella. An unusual case of porokeratosis gigantea, a morphological variant of classical porokeratosis of Mibelli, is reported. The pathogenesis, taking in account especially the clonal hypothesis and premalignant nature of porokeratosis, is discussed.
authors.affiliation: Dermatologische Universitätsklinik Regensburg.
authors.forename: A
authors.initials: A
authors.lastname: Götz
authors.forename: D
authors.initials: D
authors.lastname: Kopera
authors.forename: F
authors.initials: F
authors.lastname: Wach
authors.forename: U
authors.initials: U
authors.lastname: Hohenleutner
authors.forename: M
authors.initials: M
authors.lastname: Landthaler
mesh_terms: D017255:Acitretin / Q000627:therapeutic use; D000368:Aged; D002117:Calcitriol / Q000031:analogs & derivatives / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D017499:Porokeratosis / Q000175:diagnosis* / Q000188:drug therapy; D014212:Tretinoin / Q000627:therapeutic use; D014508:Urea / Q000627:therapeutic use; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D003879:Dermatologic Agents; D004338:Drug Combinations; D014801:Vitamin A; C055085:calcipotriene; D014212:Tretinoin; D014508:Urea; D002117:Calcitriol; D017255:Acitretin; D005472:Fluorouracil
vernacular_title: Prokeratosis Mibelli gigantea. Fallbericht und Literaturübersicht.