title: Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.
abstract: Several 5-chlorouracil and 5-chlorocytosine beta-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examined in cell culture.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Université de Montpellier II, France.
authors.forename: C
authors.initials: C
authors.lastname: Pierra
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: J P
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: A
authors.initials: A
authors.lastname: Faraj
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; D011741:Pyrimidine Nucleosides