title: Involvement of the HMGI(Y) gene in a microfollicular adenoma of the thyroid.
abstract: Follicular thyroid adenomas are epithelial tumors characterized by subgroups with specific chromosomal aberrations. Here we present a case with translocation t(1;6)(p35;p21). In 1p35 and 6p21, two genes of the high-mobility group of proteins are located. With P1-derived Artificial Chromosome (PACs) derived from the HMG17 gene located at 1p35 and HMGI(Y) located at 6p21, fluorescence in situ hybridization was performed. The breakpoints were located distal to HMG17 and proximal to HMGI(Y), but no rearrangement of the genes was shown by FISH. However, an overexpression of the HMGI(Y) gene was detected by RT-PCR as well as by immunohistochemistry techniques. This suggests a breakpoint in the proximity of the HMGI(Y) deregulating HMGI(Y) gene expression, a situation found in a variety of human benign mesenchymal tumors with involvement of chromosome band 6p21.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: A
authors.initials: A
authors.lastname: Fusco
authors.forename: G
authors.initials: G
authors.lastname: Belge
authors.forename: G
authors.initials: G
authors.lastname: Chiappetta
authors.forename: M
authors.initials: M
authors.lastname: Fedele
authors.forename: P
authors.initials: P
authors.lastname: Pauwels
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000235:genetics*; D000328:Adult; D002871:Chromosome Banding; D025741:HMGA1a Protein; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics
chemical_list: D006609:High Mobility Group Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; D025741:HMGA1a Protein