Lipids, lipoproteins, and fatty acids during infantile marasmus in the Fès area of Morocco.
The lipid composition of plasma, including total HDL and LDL cholesterol, triglycerides, apo AI, apo B, and fatty acids was investigated in 29 malnourished Moroccan children in two groups: 12 children with mild PCM, and 17 with severe PCM. Normally nourished children from the same area (n = 15) served as controls. The severe malnourished children showed a significant reduction of apo AI, total and LDL cholesterol, and an increase in the levels of triglycerides. Furthermore, these children showed a decrease in the saturated fatty acids myristic and stearic acid, and a similar decrease in the essential fatty acid (EFA) metabolites, especially eicosatrienoic acid, arachidonic acid, and eicosapentaenoic acid, with an increase in the oleic and cisvaccenic monounsaturated fatty acids. In contrast, the PCM group showed only an increase of docosatetraenoic and docosapentaenoic, with an associated decrease in myristic acid and palmitic acid. On the other hand, the indexes of delta 9 desaturase and elongase n-3 and n-6 were increased, and this was found to be related to the severity of the malnutrition. These results suggest that the severity of malnutrition is associated with an increase of desaturation and elongation of PUFA, EFA deficiency and/or peroxidation.
Houssaïni
F Z
FZ
Laboratoire de Biochimie A, CHU de Grenoble, France.
Foulon
T
T
Iraqi
M R
MR
Payen
N
N
Groslambert
P
P
D000367:Age Factors; D001835:Body Weight / Q000502:physiology; D002675:Child, Preschool; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009018:Morocco; D011502:Protein-Energy Malnutrition / Q000097:blood*; D012737:Sex Factors
D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins