title: Hydrogel contact lens dehydration and oxygen transmissibility.
abstract: OBJECTIVE
  Oxygen transmissibility is a key determinant of the physiological response of the cornea to contact lens wear. Because transmissibility is related to hydrogel water content, we conducted a study to determine the change in water content during lens wear and to quantify the impact any such change would have on transmissibility.
  
  
  METHODS
  In a double masked clinical investigation, two subjects each wore 17 different pairs of contact lenses. Water content was measured before lens wear at 35 degrees C and immediately after 4 hours of contact lens wear. Contact lens oxygen transmissibilities were calculated on each occasion.
  
  
  RESULTS
  The absolute changes in water content for the 17 lenses varied from +0.5% to -5.3%. For some lenses, this change in water content altered the lens oxygen transmissibilities to a clinically significant degree. The changes in water content and oxygen transmissibilities were greatest with FDA Group IV lenses.
  
  
  CONCLUSIONS
  Dehydration during contact lens wear can alter the oxygen transmissibility of hydrogel lenses, and in some situations, this factor may be clinically significant.
authors.affiliation: Eurolens Research, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, United Kingdom.
authors.forename: N
authors.initials: N
authors.lastname: Efron
authors.forename: P B
authors.initials: PB
authors.lastname: Morgan
mesh_terms: D003263:Contact Lenses, Hydrophilic; D003890:Desiccation; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010100:Oxygen / Q000378:metabolism*; D010539:Permeability; D011048:Polarography; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010100:Oxygen