[Experimental study on immunity and burn wound healing].
The immune system is involved in the complicated process of wound healing. In this study, we at first set up an optimal immuno-suppression model with low-doze radiation with 60Co and found that both the ratio of Th/Ts in peripheral blood and the rate of T cells adhesion to tumour cells dropped persistently, and there were no significant injuries to skin tissue DNA and cells cycle in 20 days after 2Gy radiation with 60Co. Then we investigated the influence of immuno-suppression on burn wound healing. The results showed that both ability of collagen repair and rates of wound healing after burn injury were inhibited in immuno-suppression rats. This indicated that it was necessary to improve immunity condition to enhance wound healing after severe burn injury.
Chen
Y
Y
Burns Center, Changhai Hospital, Second Military Medical University, Shanghai.
Fang
Y
Y
Yi
C
C
D000818:Animals; D002056:Burns / Q000276:immunology* / Q000503:physiopathology; D016516:CD4-CD8 Ratio / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D006909:Hydroxyproline / Q000378:metabolism; D007165:Immunosuppression Therapy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000276:immunology*
D003037:Cobalt Radioisotopes; D006909:Hydroxyproline