Serum mucin antigen (CASA) as a marker of amiodarone-induced pulmonary toxicity.
Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity.
Devine
P L
PL
Department of Obstetrics & Gynaecology, University of Queensland, Brisbane, Australia.
Siebert
W J
WJ
Morton
S L
SL
Scells
B
B
Quin
R J
RJ
Heddle
W F
WF
Zimmerman
P V
PV
Donohoe
P J
PJ
D000638:Amiodarone / Q000009:adverse effects* / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000097:blood; D006334:Heart Function Tests; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000175:diagnosis*; D018396:Mucin-1 / Q000097:blood*; D011659:Pulmonary Gas Exchange
D000889:Anti-Arrhythmia Agents; D018396:Mucin-1; D000638:Amiodarone