Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.
A new series of benzopyrano[3,4-c]pyrrole derivatives were synthesized and evaluated for their interaction with dopamine D3 versus D2 receptors. Amongst these compounds, 4x (S 33084) was found to be a potent and selective dopamine D3 receptor antagonist.
Dubuffet
T
T
Institut de Recherches Servier, Centre de Recherches de Croissy, Croissy sur Seine, France.
Newman-Tancredi
A
A
Cussac
D
D
Audinot
V
V
Loutz
A
A
Millan
M J
MJ
Lavielle
G
G
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000031:analogs & derivatives / Q000737:chemistry; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D016466:CHO Cells / Q000378:metabolism; D006224:Cricetinae; D018491:Dopamine Agonists / Q000737:chemistry; D018492:Dopamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D011758:Pyrroles / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism; D050637:Receptors, Dopamine D3; D013329:Structure-Activity Relationship; D013469:Sulpiride / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000737:chemistry; D014162:Transfection
D001578:Benzopyrans; C493593:DRD3 protein, human; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D007457:Iodine Radioisotopes; D011758:Pyrroles; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; D016244:Guanosine 5'-O-(3-Thiotriphosphate); C011799:5-hydroxy-2-N,N-dipropylaminotetralin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D013469:Sulpiride; C031349:7-hydroxy-2-N,N-dipropylaminotetralin