title: Incidence of optic neuritis in Stockholm, Sweden, 1990-1995: II. Time and space patterns.
abstract: OBJECTIVE
  To describe the time and space patterns of patients with monosymptomatic optic neuritis (MON) in Stockholm County, Sweden, and to explore the role of environmental factors in the etiology of MON and multiple sclerosis.
  
  
  METHODS
  Population-based and prospective incidence survey.
  
  
  METHODS
  Census based on referrals from 1.68 million inhabitants of Stockholm County.
  
  
  METHODS
  One hundred forty-seven new patients with MON were consecutively referred by ophthalmologists and neurologists from January 1, 1990, through December 31, 1995. A standardized questionnaire was used for data collection.
  
  
  METHODS
  Evaluations consisted of annual incidence, statistical significance of temporal aggregation, Knox test, likelihood score test applied to the ratio of the highest to lowest seasonal proportion of registered events, and standardized morbidity ratio for municipalities.
  
  
  RESULTS
  We observed a seasonal pattern of MON incidence, with the highest incidence (31%) in the spring and the lowest (17%) in the winter (ratio of highest to lowest seasonal proportion, 1.84; 95% confidence interval, 1.13-3.01; P = .007). The seasonal monthly incidences were correlated with the average number of sunny hours and the temperature. The presence of positive immune activity markers (i.e., mononuclear pleocytosis and oligoclonal IgG bands in the cerebrospinal fluid) seemed to be linked to the onset of MON in winter. No aggregation by time, space, or month of birth was detected.
  
  
  CONCLUSIONS
  Monosymptomatic optic neuritis in Stockholm County occurred at an uneven frequency across the seasons, with the highest incidence in spring and the lowest in winter. This seasonal pattern is compatible with that described in most previous reports. Environmental and probable infectious factors unevenly distributed by season may play a role in the etiology and early clinical course of MON.
authors.affiliation: Division of Neurology, Karolinska Institute, Huddinge University Hospital, Sweden. Ya-Ping.Jin@cnsf.ki.se
authors.forename: Y P
authors.initials: YP
authors.lastname: Jin
authors.forename: J
authors.initials: J
authors.lastname: de Pedro-Cuesta
authors.forename: M
authors.initials: M
authors.lastname: Söderström
authors.forename: H
authors.initials: H
authors.lastname: Link
mesh_terms: D000328:Adult; D015415:Biomarkers; D002980:Climate; D004777:Environment; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid / Q000276:immunology; D015994:Incidence; D007963:Leukocytes, Mononuclear / Q000276:immunology; D007964:Leukocytosis / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology; D009902:Optic Neuritis / Q000175:diagnosis / Q000453:epidemiology*; D011159:Population Surveillance; D011446:Prospective Studies; D012621:Seasons; D017678:Sex Distribution; D013029:Space-Time Clustering; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G