title: Flow-volume curves as measurement of respiratory mechanics during ventilatory support: the effect of the exhalation valve.
abstract: OBJECTIVE
  To assess the feasibility of expiratory flow-volume curves as a measurement of respiratory mechanics during ventilatory support: to what extent is the shape of the curve affected by the exhalation valve of the ventilator?
  
  
  METHODS
  Prospective, comparative study.
  
  
  METHODS
  Medical intensive care unit of a university hospital.
  
  
  METHODS
  28 consecutive patients with various conditions, mechanically ventilated with both the Siemens Servo 900C and 300 ventilators, were studied under sedation and paralysis.
  
  
  METHODS
  The ventilator circuit was intermittently disconnected from the ventilator at end-inspiration in order to obtain flow-volume curves with and without the exhalation valve in place.
  
  
  RESULTS
  Peak flow (PEF) and the slope of the flow-volume curve during the last 50 % of expired volume (SF50) were obtained both with and without the exhalation valve in place. The exhalation valve caused a significant reduction in peak flow of 0.3 l/s (from 1.27 to 0.97 l/s) with the Siemens Servo 900 C ventilator and of 0.42 l/s (from 1.36 to 0.94 l/s) with the Siemens Servo 300 ventilator (p < 0.001). The SF50 was not affected.
  
  
  CONCLUSIONS
  In mechanically ventilated patients, the exhalation valve causes a significant reduction in peak flow, but does not affect the SF50. This study further suggests that the second part of the expiratory flow-volume curve can be used to estimate patients' respiratory mechanics during ventilatory support.
authors.affiliation: Department of Pulmonary and Intensive Care Medicine, Erasmus Medical Centre Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. lourens@lond.azr.nl
authors.forename: M S
authors.initials: MS
authors.lastname: Lourens
authors.forename: B
authors.initials: B
authors.lastname: van den Berg
authors.forename: H C
authors.initials: HC
authors.lastname: Hoogsteden
authors.forename: J M
authors.initials: JM
authors.lastname: Bogaard
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care / Q000379:methods; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000706:statistics & numerical data*; D015656:Respiratory Mechanics