C1-esterase inhibitor reduces infarct volume after cortical vein occlusion.
In order to clarify the role of complement as a mediator of cerebral infarct growth, we inhibited the classical complement activation pathway in a photochemical cortical vein occlusion model. Immediately after occlusion, rats were infused with either 0.9% saline (vehicle), or C1-esterase inhibitor (C1-INH) over 30 min. Regional cerebral blood flow (rCBF) decreased after occlusion, and was about 50% of baseline after 2 h. No difference was noted between experimental groups. Mean arterial blood pressure (MABP) and arterial blood gases were likewise unaffected by the treatment. However, administration of C1-INH had significantly reduced infarct volume by 72%, as evaluated after 5 days survival. Thus, the neuroprotective effect cannot be explained by an improvement of cerebral perfusion but rather by protection of the parenchyma in the penumbra.
Heimann
A
A
Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-University Mainz, 55101, Mainz, Germany.
Takeshima
T
T
Horstick
G
G
Kempski
O
O
D000818:Animals; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003174:Complement C1 Inactivator Proteins / Q000494:pharmacology*; D008297:Male; D010777:Photochemistry; D051381:Rats; D017208:Rats, Wistar; D014680:Veins / Q000473:pathology
D003174:Complement C1 Inactivator Proteins