[The activity of the neuromediator systems in the cortex and caudate nucleus in rats with different degrees of initial alcohol preference].
The study was made of functional state of catecholamine, dopaminergic, serotonergic and cholinergic cerebral systems in terms of the activity of some enzymes of neuromediator metabolism, the content of biogenic amines and their correlation in brain and cerebral caudate nucleus. 3 groups of rats with different initial craving for alcohol were examined: rejecting alcohol (RA); consuming it but without preference (WAP); and rats preferring alcohol under the conditions of free choice between water and alcohol (PA). Peculiarities of the functional state of the systems studied depended on the degree of the preference to alcohol. The main changes in PA rats, as compared with RA group, manifested as a decrease of corresponding indices. That confirmed a different degree of the inhibition of their activity as well as alterations in the interaction between neuromediator systems. These changes were more pronounced in the cortex than in caudate nucleus. Such alterations may be related to structural-functional flexibility of CNS and might be the basic mechanism of the genetic predisposition to alcohol consumption.
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D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000737:chemistry / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000378:metabolism; D008297:Male; D009044:Motor Cortex / Q000737:chemistry / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D018377:Neurotransmitter Agents
Aktivnost' neĭromediatornykh sistem v kore i khvostatom iadre mozga krys s raznoĭ stepen'iu iskhodnogo predpochteniia alkogolia.