Interaction of cyclomaltononaose (delta-CD) with several drugs.
The effects of delta-cyclodextrin (delta-CD; cyclomaltononaose) on solubility of 14 drugs that are slightly soluble or insoluble in water were studied and compared with those of conventional cyclodextrins (CDs) such as alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), and gamma-cyclodextrin (gamma-CD). In general, delta-CD had a weak complex-forming ability with the drugs examined in comparison with beta-CD and gamma-CD. However, in the case of digitoxin, delta-CD enhanced solubility of the guest molecules. To determine the mechanism of inclusion complex formation of delta-CD with digitoxin, the interaction of both drugs was investigated by the solubility method and spectroscopic methods such as ultraviolet (UV) and 1H-NMR (nuclear magnetic resonance). The changes in chemical shift (1H) and hypsochromic shift of UV suggested that digitoxin was partially included in the cavity of delta-CD.
Ueda
H
H
Department of Physical Chemistry, Hoshi University, Tokyo, Japan.
Wakamiya
A
A
Endo
T
T
Nagase
H
H
Tomono
K
K
Nagai
T
T
D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000494:pharmacology*; D004347:Drug Interactions; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011522:Protons; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014867:Water / Q000737:chemistry
D003505:Cyclodextrins; D011522:Protons; C121706:delta-cyclodextrin; D014867:Water