Synthesis and pharmacological evaluation of some thiolupinine derivatives.
A small set of 9-(lupinylthio)xanthene, -thioxanthenes and alpha-(lupinylthio)diphenylmethanes was prepared and found to inhibit the angiotensin II-induced contractions of guinea pig ileum. Some of these compounds were also moderately active in vitro as tracheal relaxants and one compound was more active than aspirin against arachidonic acid-induced platelet aggregation.
Novelli
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Dipartimento di Scienze Farmaceutiche, Università di Genova, Italy.
Tasso
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Sparatore
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D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011807:Quinolizines / Q000737:chemistry*; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet; D014132:Trachea / Q000187:drug effects*
D010975:Platelet Aggregation Inhibitors; D011807:Quinolizines; D000804:Angiotensin II; C084215:thiolupinine