Combined malignant hemangiopericytoma and deep venous thrombosis. A case report.
Malignancies, antiproliferative drug treatment, cancer-related conditions like immobilization, perioperative status and radiotherapy are risk factors for hypercoagulability. Setting aside mass or invasion-related venous thrombosis, the differential diagnosis regarding the etiopathogenesis (paraneoplastic syndrome or antiproliferative treatment) is usually problematic. The authors report a case of combined malignant hemangiopericytoma and recurrent deep venous thrombosis in the right inferior limb. Through a literature review, the following issues are discussed: 1) the criteria for cyto-histopathologic assessment; 2) the involvement of pericytes both in coagulation and platelet aggregation; 3) the importance of discriminating true paraneoplastic syndromes from other tumor-related clinical manifestations; 4) the response to external radiotherapy of malignant hemangiopericytoma as limited disease; 5) the poor results of doxorubicin-ifosfamide polychemotherapy and dacarbazine monochemotherapy in metastatic disease. Although doxorubicin-ifosfamide treatment was in progress in the reported case, the authors conclude that the recurrent deep venous thrombosis is likely to be paraneoplastic, even if such a diagnosis has not been previously reported in the literature.
Campanella
N
N
Divisione di Patologia Medica, Azienda Ospedaliera Umberto I - Torrette, Ancona, Italy.
Ferretti
M
M
Daher
W
W
Pergolini
M
M
De Nictolis
M
M
D003937:Diagnosis, Differential; D006393:Hemangiopericytoma / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis*; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000150:complications* / Q000175:diagnosis*