title: Prognosis in Duke's B colorectal carcinoma: the Jass classification revisited.
abstract: OBJECTIVE
  To assess whether Jass staging enhances prognostic prediction in Dukes' B colorectal carcinoma.
  
  
  METHODS
  A historical cohort observational study.
  
  
  METHODS
  A university tertiary care centre, Switzerland.
  
  
  METHODS
  108 consecutive patients.
  
  
  METHODS
  Curative resection of Dukes' B colorectal carcinoma between January 1985 and December 1988, Patients with familial adenomatous polyposis; hereditary non-polyposis colorectal cancer; Crohns' disease; ulcerative colitis and synchronous and recurrent tumours were excluded. A comparable group of 155 consecutive patients with Dukes' C carcinoma were included for reference purposes.
  
  
  METHODS
  Disease free and overall survival for Dukes' B and overall survival for Dukes' C tumours.
  
  
  RESULTS
  Dukes' B tumours in Jass group III or with an infiltrated margin had a significantly worse disease-free survival (p = 0.001 and 0.0001, respectively) and those with infiltrated margins had a significantly worse overall survival (p = 0.002). Overall survival among those with Dukes' B Jass III and Dukes' B with infiltrated margins was no better than overall survival among all patients with Dukes' C tumours.
  
  
  CONCLUSIONS
  Jass staging and the nature of the margin of invasion allow patients undergoing curative surgery for Dukes' B colorectal carcinoma to be separated into prognostic groups. A group of patients with Dukes' B tumours whose prognosis is inseparable from those with Dukes' C tumours can be identified, the nature of the margin of invasion being used to classify a larger number of patients.
authors.affiliation: Department of Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: N
authors.initials: N
authors.lastname: De Quay
authors.forename: J P
authors.initials: JP
authors.lastname: Cerottini
authors.forename: X
authors.initials: X
authors.lastname: Albe
authors.forename: E
authors.initials: E
authors.lastname: Saraga
authors.forename: J C
authors.initials: JC
authors.lastname: Givel
authors.forename: S
authors.initials: S
authors.lastname: Caplin
mesh_terms: D000368:Aged; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis