title: Chemical and enzymatic synthesis and antiviral properties of 2'-deoxy-2'-fluoroguanosine.
abstract: Chemical and enzymatic methods were employed for the synthesis of the title compound, 2'F-Guo 7. High antiviral activity of 2'F-Guo was established in chick embryo cells infected with influenza virus FPV/Rostock/34 (H7N1) and herpes simplex virus (HSV) type I (1C strain).
authors.affiliation: Institute of Bioorganic Chemistry, National Academy of Sciences, Belarus.
authors.forename: G V
authors.initials: GV
authors.lastname: Zaitseva
authors.forename: A I
authors.initials: AI
authors.lastname: Zinchenko
authors.forename: V N
authors.initials: VN
authors.lastname: Barai
authors.forename: N I
authors.initials: NI
authors.lastname: Pavlova
authors.forename: E I
authors.initials: EI
authors.lastname: Boreko
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhailopulo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002642:Chick Embryo; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009975:Orthomyxoviridae / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C083670:2'-deoxy-2'-fluoroguanosine; D003849:Deoxyguanosine