[Inherited defect of platelet nitric oxide synthase activity in essential hypertension].
The collagen-provocated platelet nitric oxide synthase (NOS) activity by the method of 3H-labelled L-arginine was compared between 19 essential hypertensives (EH) and 21 controls, and between 13 adolescents with their both parent hypertensives (FH+) and 12 adolescents without genetic hypertensive predisposition (FH-) as well. Results showed that the platelet NOS activity was lower significantly in EH group (4.76 +/- 2.01 vs 8.09 +/- 2.36 pmol.g-1.min-1, P < 0.001) and in FH+ group (3.64 +/- 2.07 vs 5.51 +/- 2.13 pmol.g-1.min-1, P < 0.05) comparing with their control groups respectively. It suggests that the inherited defect of some anti-hypertensive mechanisms like NO/NOS system may be implicated in the development of EH, which can be taken as a new "genetic marker" for detecting of specific clinic subtype. An useful data was thus presented of value in screening referred genes, for early prevention and rational remedy in essential hypertension.
Chu
S
S
Shanghai Institute of Hypertension, Shanghai Second Medical University.
Zhao
G
G
Du
J
J
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052250:Nitric Oxide Synthase Type III
D005819:Genetic Markers; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III