Further improvements in dose distributions are unlikely to affect cure rates.
The development of computers and computer-controlled devices has, on the whole, had a profound impact on how things are accomplished in our industrialized society, and this is true for radiation therapy as well. In most issues of Medical Physics there are papers describing how computer-controlled accelerators and multi-leaf collimators used in combination with advanced treatment-planning systems, which in turn require multiple CT or MRI scans, can produce more uniform and precisely defined dose distributions limited to the treatment volume, and thereby permit larger tumor doses. The inherent assumption underlying this so-called Conformal Therapy is that its introduction will result in higher cure rates; however, there is scant evidence to support this assumption, and it is possible that the reverse may be true. It is recommended that randomized/prospective trials of this new technology be undertaken before it becomes so widespread that such an evaluation is no longer possible.
Schulz
R J
RJ
schulz@pshift.com
D055592:Biophysical Phenomena; D001703:Biophysics; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000532:radiotherapy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D011880:Radiotherapy Planning, Computer-Assisted; D015996:Survival Rate