title: [Influence of escharectomy during burn shock stage upon the changes in endothelin and NO].
abstract: OBJECTIVE
  To observe influence of escharectomy during and after burn shock stage upon the changes in plasma ET and NO.
  
  
  METHODS
  35% TBSA full-thickness burn was produced in pigs, which were divided into two groups. Group S was a group undergoing escharectomy during burn shock stage at 24 h postburn. Group C was a group receiving escharectomy at 96 h after injury. ET and NO were determined and ET/NO was calculated.
  
  
  RESULTS
  The levels of ET and NO were higher after injury than before injury in both groups. The level of ET was lower significantly in group S than in group C from 96 h postburn on. The level of NO was higher in group S than in group C. The ET/NO was lower in group S than in group C from PBH 24 on.
  
  
  CONCLUSIONS
  Escharectomy during burn shock stage was beneficial in reducing injury of endothelial cells, decreasing exudation and edema, decreasing tissue hypoxia and improving microcirculation.
authors.affiliation: Burn Institute of People's Liberation Army, 304th Hospital, Beijing.
authors.forename: S
authors.initials: S
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: He
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D002056:Burns / Q000097:blood / Q000601:surgery*; D016232:Endothelins / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D012774:Shock, Traumatic / Q000097:blood / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D016232:Endothelins; D009569:Nitric Oxide