Relevance of Fc gamma RIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients.
The immunoglobulin receptor Fc gamma RIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and gamma delta T cells, and is polymorphic. Fc gamma RIIIa-158V has a higher affinity for both monomeric and immune complexed IgG1, IgG3, and IgG4 than IIIa-158F. We determined Fc gamma RIIIa-158V/F genotypes of Japanese patients with adult periodontitis. A significant over-representation of Fc gamma RIIIa-158F was found in patients with recurrence, compared with patients without recurrence, making Fc gamma RIIIA a candidate gene for recurrence risk of adult periodontitis.
Sugita
N
N
Department of Periodontology, Niigata University School of Dentistry, Japan.
Yamamoto
K
K
Kobayashi
T
T
Van Der Pol
W
W
Horigome
T
T
Yoshie
H
H
Van De Winkel
J G
JG
Hara
K
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics / Q000276:immunology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D010649:Phenylalanine / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000276:immunology*; D017452:Receptors, IgG / Q000235:genetics*; D012008:Recurrence; D014633:Valine / Q000235:genetics*
D017452:Receptors, IgG; D010649:Phenylalanine; D014633:Valine