title: Granulocyte colony stimulating factor-producing diffuse malignant mesothelioma of pleura.
abstract: We report the rare case of a 61-year-old man with a diffuse malignant mesothelioma of mixed subtype which produced granulocyte colony-stimulating factor (G-CSF). The white blood cell (WBC) was elevated to 85,100/mm3 without any evidence of infection, and the G-CSF level in the pleural effusion was also increased at 13,200 pg/ml. The lobes of the lung were encased in a tumor. Histopathologically, the tumor cells were of a polymorphous morphology with an epithelial and sarcomatoid mixed pattern. Immunohistochemistry showed that the tumor cells were positive for vimentin, cytokeratin, epithelial membrane antigen, thrombomodulin, and G-CSF, and negative for carcinoembryonic antigen (CEA), CD34, and surfactant apoprotein-A.
authors.affiliation: Department of Internal Medicine, Showa Hospital, Gifu.
authors.forename: H
authors.initials: H
authors.lastname: Ohbayashi
authors.forename: H
authors.initials: H
authors.lastname: Nosaka
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Yamase
authors.forename: K
authors.initials: K
authors.lastname: Yamaki
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007955:Leukemoid Reaction; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor