title: Radioimmunoscintigraphy in patients with ovarian cancer.
abstract: The targeting potential of three different monoclonal antibodies (MAbs) was assessed in patients with ovarian cancer. HMFG1, OC-125 and H17E2 labelled with 111In or 123I were evaluated prospectively for their ability to localize ovarian tumour. Forty two patients with ovarian cancer, aged 40-78 years (median = 58 years) were studied using OC-125 (n = 9), HMFG1 (n = 11) and H17E2 (n = 22). Imaging data were compared with the CT and the surgical findings. Presence of tumour was confirmed in 35/42 (83%) patients (8/9 OC-125, 10/11 HMFG1 and 17/22 H17E2) and correlated well with the conventional radiology diagnostic methods. One patient with a negative H17E2 scan and a large abdominal mass detected at laparotomy revealed a PLAP-negative tumour on immunohistochemistry. Scintigraphy revealed the presence of active disease, confirmed by laparotomy/laparoscopy in 6/8 patients considered to be in clinical remission. The sensitivity of the method was high enough and the diagnostic contribution of this approach should be further evaluated.
authors.affiliation: Department of Medicine/Oncology, University Hospital of Patras, Rion, Greece. kalofon@med.upatras.gr
authors.forename: H P
authors.initials: HP
authors.lastname: Kalofonos
authors.forename: C
authors.initials: C
authors.lastname: Giannakenas
authors.forename: C
authors.initials: C
authors.lastname: Kosmas
authors.forename: D
authors.initials: D
authors.lastname: Apostolopoulos
authors.forename: A
authors.initials: A
authors.lastname: Onienadum
authors.forename: T
authors.initials: T
authors.lastname: Petsas
authors.forename: D
authors.initials: D
authors.lastname: Dimopoulos
authors.forename: A A
authors.initials: AA
authors.lastname: Epenetos
authors.forename: P J
authors.initials: PJ
authors.lastname: Vassilakos
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016719:Radioimmunodetection / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes