[The use of the nucleolar apparatus indices of the leukemic cells in patients with acute myeloblastic leukemia for the early detection of resistant clones].
Changes were studied in the value for the nucleolar coefficient as were the percentage of large and compact nucleoli and numbers of Ag-NOR in the peripheral blood of patients with acute myeloblastic leukemia in order that resistant clones might be identified as early as possible. It has been ascertained that within 24 hours of the start of polychemotherapy "7 + 3" leukotic cells respond in different ways to the chemotherapeuticals employed depending on the outcome of the illness.
Andreeva
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D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D002360:Carubicin / Q000008:administration & dosage / Q000494:pharmacology; D002466:Cell Nucleolus / Q000187:drug effects*; D003561:Cytarabine / Q000008:administration & dosage / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D018931:Antineoplastic Agents, Hormonal; D003561:Cytarabine; D011239:Prednisolone; D002360:Carubicin
Ispol'zovanie nekotorykh pokazateleĭ iadryshkovogo apparata leĭkoznykh kletok bol'nykh ostrym mieloblastnym leĭkozom dlia rannego vyiavleniia rezistentnykh klonov.