[Klebsiella pneumoniae glycoproteins as coadjuvants in the prevention of recurrent respiratory infections in children 1-6 years of age].
METHODS
Forty two children with clinical diagnosis of recurrent high and low respiratory infections, were treated with an extract of P1 and F1 glycoproteins; fraction of Klebsiella pneumoniae, 1 g/day for one week a month for three months, according to a double-blind, randomized, parallel group trial.


RESULTS
Improvement of clinical and laboratory results were compared with 44 control patients with the same age and similar sex distribution, that were treated with placebo. At the end of study, clinical analysis at 6, 9 and 12 months after the initial dose of Klebsiella pneumoniae, decreased in the number of respiratory infections, sick days, and school assistance were observed in the study group when compared with the control group (p < 0.001 in all parameters). There were not statistical significant changes in hemolytic complement, C3, C4 and immunoglobulins (IgA, IgG, IgM and IgE) levels before and after treatment and between groups. There were not observed adverse reactions to oral treatment with this extract of Klebsiella pneumoniae.


CONCLUSIONS
These results suggested that the extract of Klebsiella can be used as a coadjuvant in the treatment of pediatric patients with recurrent high and low respiratory infections.
Arroyave
C M
CM
Facultad de Medicina, Universidad Autónoma de Querétaro, México.
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial / Q000276:immunology*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D010865:Pilot Projects; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000276:immunology / Q000517:prevention & control*; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D006023:Glycoproteins
Glicoproteínas de Klebsiella pneumoniae como coadyuvantes en la prevención de infecciones recurrentes respiratorias en niños de 1 a 6 años de edad.