Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma.
OBJECTIVE
To compare the efficacy of iodine-125 (125I) and ruthenium-106 (106Ru) episcleral plaque radiation therapy and proton beam radiation therapy (PBRT) in the treatment of choroidal melanoma.


METHODS
A retrospective, nonrandomized comparative study.


METHODS
Charts of patients treated with 125I, 106Ru, and PBRT for choroidal melanoma between January 1988 and June 1996 at St. Bartholomew's Hospital and Moorfields Eye Hospitals were reviewed.


METHODS
Local control of choroidal melanomas after 125I, 106Ru, or PBRT.


RESULTS
A total of 597 patients were identified (125I = 190, 106Ru = 140, PBRT = 267). Patients treated with 106Ru had a significantly greater risk of local tumor recurrence than did patients treated with either 125I (P = 0.0133; confidence interval [CI], 1.26-7.02; risk ratio, 2.97) or PBRT (P = 0.0097; CI, 1.30-6.66; risk ratio, 2.94). A stepwise Cox proportional hazard model found maximal basal diameter to be a significant covariate (P = 0.0033).


CONCLUSIONS
Patients treated with 106Ru had a significantly greater risk of local tumor recurrence than did those patients treated with either 125I or PBRT.
Wilson
M W
MW
St. Bartholomew's Hospital, London, England.
Hungerford
J L
JL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011522:Protons; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D012307:Risk Factors; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D012590:Sclera / Q000528:radiation effects; D014792:Visual Acuity
D007457:Iodine Radioisotopes; D011522:Protons; D012429:Ruthenium Radioisotopes