title: Necrobiotic palisading granuloma at injection site of disodium clodronate: A case report.
abstract: The authors describe an adverse localized cutaneous reaction caused by the injection of disodium clodronate, histologically presenting as a necrobiotic palisading granuloma. This lesion is considered as an immunological type of granuloma that can be caused by various chemical or physical stimuli. Disodium clodronate should be included among the medicaments that can trigger this infrequent type of tissue reaction.
authors.affiliation: Institute of Pathological Anatomy and Histology, University of Siena, Italy.
authors.forename: A V
authors.initials: AV
authors.lastname: Lalinga
authors.forename: M
authors.initials: M
authors.lastname: Pellegrino
authors.forename: L
authors.initials: L
authors.lastname: Laurini
authors.forename: C
authors.initials: C
authors.lastname: Miracco
mesh_terms: D000368:Aged; D000701:Analgesics, Opioid / Q000009:adverse effects*; D004002:Clodronic Acid / Q000009:adverse effects*; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007273:Injections, Intramuscular; D017441:Necrobiotic Disorders / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000701:Analgesics, Opioid; D004002:Clodronic Acid