title: Are autoantibodies against Lewis antigens involved in the pathogenesis of Helicobacter pylori-induced peptic ulcers?
abstract: We examined whether anti-Lewis x (Le(x)) and y (Le(y)) autoantibodies affect the pathogenesis of Helicobacter pylori-induced peptic ulcers. Of 11 patients with peptic ulcers, 10 patients had both anti-Le(x) and -Le(y) immunoglobulin G (IgG) antibodies, and 1 patient had only anti-Le(x) antibody. After successful eradication, we measured the serum titer of anti-Le(x) and -Le(y) antibodies. Six patients had a reduction of the titers of anti-Le(x) and/or -Le(y) antibodies, whereas no notable changes were detected in 5 patients in the follow-up. This result suggests that anti-Le(x) and -Le(y) autoantibodies had no critical role in the development of H. pylori-induced peptic ulcer.
authors.affiliation: Second Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kamiya
authors.forename: T
authors.initials: T
authors.lastname: Arisawa
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: K
authors.initials: K
authors.lastname: Shibayama
authors.forename: T
authors.initials: T
authors.lastname: Horii
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: M
authors.initials: M
authors.lastname: Ohta
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000188:drug therapy / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D016256:Lewis X Antigen / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D010437:Peptic Ulcer / Q000209:etiology* / Q000276:immunology; D012008:Recurrence
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; C094162:Lewis Y antigen; D008070:Lipopolysaccharides