[Effect of acetaldehyde on the formation of alcohol dependence in animal experiments].
As a result of the experiment on the laboratory animals under the continuous administration of acetaldehyde there has been revealed the latter as inducing the aldehyde dehydrogenase activity in the cytosol fraction of the cerebral structures/hypothalamus, mid-brain and new cerebrum cortex/as well as in the levels of biogenic amines/noradrenaline and 5-hydroxytryptamine/in the same structures while forming experimentally in the laboratory animals the alcoholic dependence under acetaldehyde alcoholic dependence. The work displays some changes of alcohol dehydrogenase and action.
Kharchenko
N K
NK
Ukrainian SRI of Social and Justicial Psychiatry, Interdepartmental Centre of Experimental and Clinical Narcology.
D000079:Acetaldehyde / Q000494:pharmacology*; D000437:Alcoholism / Q000209:etiology*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D007274:Injections, Intraperitoneal; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000201:enzymology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D009638:Norepinephrine
Vliianie atsetal'degida na formirovanie alkogol'noĭ zavisimosti v éksperimentakh na zhivotnykh.