The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.
Bowman
S
S
Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK. sharen@sanger.ac.uk
Lawson
D
D
Basham
D
D
Brown
D
D
Chillingworth
T
T
Churcher
C M
CM
Craig
A
A
Davies
R M
RM
Devlin
K
K
Feltwell
T
T
Gentles
S
S
Gwilliam
R
R
Hamlin
N
N
Harris
D
D
Holroyd
S
S
Hornsby
T
T
Horrocks
P
P
Jagels
K
K
Jassal
B
B
Kyes
S
S
McLean
J
J
Moule
S
S
Mungall
K
K
Murphy
L
L
Oliver
K
K
Quail
M A
MA
Rajandream
M A
MA
Rutter
S
S
Skelton
J
J
Squares
R
R
Squares
S
S
Sulston
J E
JE
Whitehead
S
S
Woodward
J R
JR
Newbold
C
C
Barrell
B G
BG
D000818:Animals; D001483:Base Sequence; D002503:Centromere; D002874:Chromosome Mapping; D002875:Chromosomes; D016054:DNA, Protozoan; D018503:Genome, Protozoan; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics; D017422:Sequence Analysis, DNA; D016615:Telomere
D016054:DNA, Protozoan; D015800:Protozoan Proteins