Oral desensitization to 5-aminosalicylic acid medications.
BACKGROUND
Although hypersensitive subjects have been desensitized to oral sulfasalazine, the feasibility of oral desensitization to the drug's active moiety, 5-aminosalicylic acid has been questioned and never been reported.


METHODS
We devised a 5-aminosalicylic acid desensitization protocol and administered the drug to two hypersensitive subjects on three occasions.


RESULTS
Both 5-aminosalicylic acid hypersensitive subjects were successfully desensitized without complications and were able to tolerate therapeutic doses.


CONCLUSIONS
Despite changing the drug's properties by crushing it for incrementally increasing administration, we successfully desensitized two patients on three occasions with 5-aminosalicylic acid.
Stelzle
R C
RC
Walter Reed Army Medical Center, Department of Allergy & Immunology, MCHC-AL, Washington, DC 20307-5001, USA.
Squire
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EN
D000284:Administration, Oral; D000293:Adolescent; D000368:Aged; D003888:Desensitization, Immunologic / Q000379:methods; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000276:immunology; D005260:Female; D006801:Humans; D019804:Mesalamine / Q000008:administration & dosage* / Q000276:immunology*
D019804:Mesalamine