Synthesis of cis-disubstituted cyclobutenyl nucleoside analogues.
cis-Disubstituted cyclobutene nucleosides analogues were prepared by a linear synthesis starting from cis-cyclobutene dicarboxylic anhydride. This strategy involved mild reaction conditions with intent to restrict the thermal electrocyclic ring opening into (Z,E)-dienes.
Gourdel-Martin
M E
ME
Laboratoire de Synthèse Organique, ESA 6011, Faculté des Sciences, Université du Maine, Le Mans, France.
Huet
F
F
D000475:Alkenes / Q000737:chemistry*; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000475:Alkenes; D009705:Nucleosides