title: Cerebral glucose metabolism in unilateral entorhinal cortex-lesioned rats: an animal PET study.
abstract: To evaluate the effect of entorhinal cortical lesion on cerebral cortical function, we studied cerebral glucose utilization (CMRGlc) using a high resolution PET scanner after quinolinic acid lesion of the unilateral entorhinal cortex in rats. [18F]Fluorodeoxyglucose PET was performed at 4 days and 4 weeks after surgery, and CMRGlc in the bilateral frontal, parietal and temporal regions were analyzed. At 4 days, the entorhinal lesion induced a 12-15% decrease in CMRGlc of frontal, parietal and temporal regions ipsilateral to the lesion. The hypometabolism continued at 4 weeks in the temporal region. These findings suggest that entorhinal lesion induces cerebral cortical hypometabolism, which implies a pathogenetic role of entorhinal area on the cortical hypometabolism in Alzheimer's disease.
authors.affiliation: Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumi
authors.forename: T
authors.initials: T
authors.lastname: Hanakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nagahama
authors.forename: H
authors.initials: H
authors.lastname: Yamauchi
authors.forename: H
authors.initials: H
authors.lastname: Tsukada
authors.forename: H
authors.initials: H
authors.lastname: Shibasaki
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018728:Entorhinal Cortex / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D008297:Male; D009498:Neurotoxins / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014055:Tomography, Emission-Computed
chemical_list: D009498:Neurotoxins; D005947:Glucose