[Carbamazepine-induced involuntary movements in a girl with localization-related epilepsy].
I reported here girl with localization-related epilepsy who developed particular involuntary movements (IVMs) with a therapeutic dosis of carbamazepine. An epileptic seizure, loss of consciousness followed by a tonic-clonic seizure on the left, occurred at 9 and half years and carbamazepine was administrated. With the blood levels of 9.3 micrograms/ml (4 hours after administration), oral dyskinesia, choreiform movements of fingers of both sides, and myoclonus of the left arm developed. These IVMs disappeared soon after the decrease of the dosis (5.8 micrograms/ml, 6 hours after administration). As there was no other clinical and laboratory findings responsible for these IVMs, carbamazepine was thought to be the causative agent for them. The neurons and neural system related to the localization-related epilepsy may also have been involved.
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Department of Pediatrics, Otsu Red Cross Hospital, Shiga.
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D004828:Epilepsies, Partial / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005260:Female; D006801:Humans
D000927:Anticonvulsants; D002220:Carbamazepine