Evaluation of pilocarpine loaded gelatin particles for topical ophthalmic use.
Gelatin particles containing pilocarpine HCl were prepared using a desolvation method. The influence of the gelatin type and the preparation pH on particle properties was studied. The drug entrapment amounted 44 to 57%, zetapotential was slightly negative. Particle size varied from 312 nm to 500 nm depending on preparation pH. Franz diffusion cell experiments showed a release approaching zero-order kinetics and a sustained release compared to an aqueous pilocarpine HCl solution.
Vandervoort
J
J
Laboratorium Farmaceutische Technologie en Biofarmacie UIA, Wilrijk.
Ludwig
A
A
D005079:Excipients; D005780:Gelatin; D005782:Gels; D008916:Miotics / Q000008:administration & dosage* / Q000032:analysis; D010316:Particle Size; D010862:Pilocarpine / Q000008:administration & dosage* / Q000032:analysis
D005079:Excipients; D005782:Gels; D008916:Miotics; D010862:Pilocarpine; D005780:Gelatin