[Acute renal failure, intravascular hemolysis and toxic hepatitis caused by repeated use of rifampicin (case report)].
We report the case of a 57-year-old man treated with interrupted rifampicin therapy for urinary tract tuberculosis who experienced acute renal failure, intravascular hemolysis and toxic hepatitis. This combined adverse reactions are rare. Supportive treatment with dialysis and withdrawal of rifampicin result with complete recovery. Interrupted and intermittent therapy with rifampicin should be avoided and noncompliant patients should be given alternative treatment when possible.
Sefer
S
S
KB Sestre milosrdnice, Klinika za unutarnje bolesti, Zavod za nefrologiju i dijalizu, Zagreb.
Ivanusa
M
M
Kes
P
P
Ratković-Gusić
I
I
Vasilj
D
D
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000904:Antibiotics, Antitubercular / Q000506:poisoning* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006461:Hemolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000506:poisoning* / Q000627:therapeutic use; D014401:Tuberculosis, Urogenital / Q000188:drug therapy
D000904:Antibiotics, Antitubercular; D012293:Rifampin
Akutno bubrezno zatajenje, intravaskularna hemoliza i toksicni hepatitis uzrokovani opetovanim uzimanjem rifampicina (prikaz bolesnika).