title: Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects.
abstract: Traditional lipophilicity parameters (log P and log D) are well-known physico-chemical descriptors largely used in QSAR studies. Besides their numerical value, log P data contain a variety of information about inter- and intramolecular forces affecting partitioning and its related biological phenomena. The deconvolution of information from log P can be accessed only by adequate interpretative tools, such as new lipophilic-combined descriptors, of which features and some applications are presented in this review.
authors.affiliation: Institut de Chimie Thérapeutique, Section de Pharmacie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
authors.initials: G
authors.lastname: Caron
authors.initials: F
authors.lastname: Reymond
authors.initials: PA
authors.lastname: Carrupt
authors.initials: HH
authors.lastname: Girault
authors.initials: B
authors.lastname: Testa