Molecular mechanisms of copper homeostasis.
Copper is an essential trace element which plays a pivotal role in cell physiology as it constitutes a core part of important cuproenzymes. Novel components of copper homeostasis in humans have been identified recently which have been characterised at the molecular level. These include copper-transporting P-type ATPases, Menkes and Wilson proteins, and copper chaperones. These findings have paved the way towards better understanding of the role of copper deficiency or copper toxicity in physiological and pathological conditions.
Camakaris
J
J
Department of Genetics, University of Melbourne, Parkville, Victoria, 3052, Australia. j.camakaris@genetics.unimelb.edu.au
Voskoboinik
I
I
Mercer
J F
JF
D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D027682:Cation Transport Proteins; D003300:Copper / Q000172:deficiency / Q000378:metabolism* / Q000633:toxicity; D000073840:Copper-Transporting ATPases; D006527:Hepatolenticular Degeneration / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D011993:Recombinant Fusion Proteins
D002352:Carrier Proteins; D027682:Cation Transport Proteins; D018832:Molecular Chaperones; D011993:Recombinant Fusion Proteins; D003300:Copper; D000251:Adenosine Triphosphatases; C081184:ATP7A protein, human; D000073840:Copper-Transporting ATPases