[Guillain-Barré syndrome with cerebellar symptoms and elevated serum anti-GD1b IgG antibody].
We reported a 46-year-old woman with Guillain-Barré syndrome (GBS) after suffering from common cold. She also had cerebellar symptoms; ataxic speech, poor finger-nose and heel-knee tests, dysmetria, dysdiadochokinesis, poor one foot standing, positive Mann's test, ataxic gait, and poor tandem gait without Romberg's sign, and sensory disturbance. We ruled out other diseases with cerebellar symptoms; for example, Wernicke encephalopathy, multiple sclerosis, cerebellar vascular disease and encephalitis in the brain stem and cerebellum. Anti-GD1bIgG antibody was elevated in her serum in the acute phase. She was treated with immuno-adsorption therapy (TR-350) in the acute phase. The antibody titer decreased with clinical improvement after immuno-adsorption therapy. The involvement of the anti-GD1bIgG antibody in the pathogenetic mechanism of peripheral neuropathy and cerebellar symptoms was suggested.
Araki
T
T
Department of Neurology, Kawaguchi Municipal Medical Center.
Kusunoki
S
S
Arai
Y
Y
Terashi
A
A
D001323:Autoantibodies / Q000097:blood*; D002526:Cerebellar Diseases / Q000276:immunology*; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C033851:ganglioside, GD1b