title: The influence of simultaneous intra-aortic balloon pumping and mechanical ventilation on hemodynamic parameters--numerical simulation.
abstract: Intra-aortic balloon counterpulsation (IABC) is one of the methods to assist circulation. Its application is supposed to increase coronary blood flow (Qcor) and myocardial oxygen supply. Mechanical ventilation of the lungs causes some side effects that influence mainly hemodynamics, i.e. it decreases cardiac output (CO) and systemic aortic pressure (Pas) but increases systemic venous pressure (Pvs). The aim of this study was to assess the influence of IABC on hemodynamic parameters when mechanical ventilation of the lungs is used as well. We assumed pathological conditions of the heart as reduced left ventricle elastance (Ev = 0.77 mmHg/cm3) and increased left ventricle rest volume (V0 = 10 cm3). Also peripheral systemic arterial resistance (Ras) took three different values. CARDIOSIM, a computer simulator of the human cardiovascular system, was used to assess the changes of hemodynamic parameters [CO, Pas, Pvs, and pulmonary arterial pressure (Pap)] when IABC and mechanical ventilation of the lungs were applied simultaneously. Computer simulation showed that application of IABC increased such variables as CO (by approximately equal to 17%), maximum value of Pas (by approximately equal to 20%), while left atrial pressure (Pla) was diminished (by approximately equal to 30%). On the other hand, Pvs and Pap were not strongly affected by IABC, but they were dramatically dependent on intrathoracic pressure. This means that Pvs, Pap, and Pla should be carefully monitored during IABC and artificial ventilation.
authors.affiliation: Institute of Biocybernetics and Biomedical Engineering PAN, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Darowski
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: F
authors.initials: F
authors.lastname: Clemente
authors.forename: M
authors.initials: M
authors.lastname: Guaragno
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008955:Models, Cardiovascular; D011651:Pulmonary Artery / Q000502:physiology; D012121:Respiration, Artificial; D014655:Vascular Resistance / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology