Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.
Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.
Mosser
D M
DM
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA. dmmosser@astro.temple.edu
Karp
C L
CL
D000818:Animals; D015658:HIV Infections / Q000276:immunology; D006660:Histoplasmosis / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D018664:Interleukin-12 / Q000096:biosynthesis*; D007896:Leishmaniasis / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008457:Measles / Q000276:immunology; D011971:Receptors, Immunologic / Q000502:physiology*
D011971:Receptors, Immunologic; D018664:Interleukin-12