title: Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.
abstract: Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.
authors.affiliation: Second Department of Surgery, School of Medicine, Hokkaido University, Kita-Ku, Sapporo 060-8638, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hida
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyasaka
authors.forename: S
authors.initials: S
authors.lastname: Horita
authors.forename: Y
authors.initials: Y
authors.lastname: Fujioka
authors.forename: K
authors.initials: K
authors.lastname: Nagashima
authors.forename: H
authors.initials: H
authors.lastname: Katoh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001661:Biliary Tract Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D017228:Hepatocyte Growth Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis*; D012008:Recurrence; D016019:Survival Analysis
chemical_list: D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met