In vitro activities of polycationic peptides alone and in combination with clinically used antimicrobial agents against Rhodococcus equi.
The in vitro activities of magainin II, nisin, and ranalexin alone and in combination with other antimicrobial agents against six clinical isolates of Rhodococcus equi were investigated by MIC and time-kill studies. All isolates were more susceptible to nisin. A positive interaction was observed when the peptides were combined with ampicillin, ceftriaxone, rifabutin, rifampin, azithromycin, clarithromycin, and vancomycin.
Giacometti
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A
Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy. cmalinf@popsci.unian.it
Cirioni
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O
Ancarani
F
F
Del Prete
M S
MS
Fortuna
M
M
Scalise
G
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D004357:Drug Synergism; D006801:Humans; D054806:Magainins; D008826:Microbial Sensitivity Tests; D009561:Nisin / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D016929:Rhodococcus equi / Q000187:drug effects* / Q000302:isolation & purification; D029867:Xenopus Proteins
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D054806:Magainins; D010455:Peptides; D010456:Peptides, Cyclic; D029867:Xenopus Proteins; C053301:magainin 2 peptide, Xenopus; D009561:Nisin; C086618:ranalexin