title: The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
abstract: Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.
authors.affiliation: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK. sharen@sanger.ac.uk
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authors.lastname: Squares
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authors.lastname: Sulston
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authors.lastname: Whitehead
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mesh_terms: D000818:Animals; D001483:Base Sequence; D002503:Centromere; D002874:Chromosome Mapping; D002875:Chromosomes; D016054:DNA, Protozoan; D018503:Genome, Protozoan; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics; D017422:Sequence Analysis, DNA; D016615:Telomere
chemical_list: D016054:DNA, Protozoan; D015800:Protozoan Proteins