Comparison of anti-HBV activity of beta-D- and beta-L-DDA-5'monophosphate prodrugs and effectiveness in combination with lamivudine.
We have investigated the effects of several beta-D-ddA 5'-monophospate (beta-D-ddAMP), and their corresponding beta-L-enantiomers prodrugs against HBV replication. All ddAMP prodrugs inhibited HBV replication in a dose-dependent manner.
Loi
A G
AG
Department of Pharmacology, Univ. of Alabama at Birmingham, USA.
Faraj
A
A
Pierra
C
C
Gosselin
G
G
Imbach
J L
JL
Locarnini
S A
SA
Groman
E V
EV
Schinazi
R F
RF
Sommadossi
J P
JP
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003838:Deoxyadenine Nucleotides / Q000494:pharmacology*; D054306:Dideoxynucleotides; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D019259:Lamivudine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003838:Deoxyadenine Nucleotides; D054306:Dideoxynucleotides; C010110:2',3'-dideoxyadenosine 5'-phosphate; D019259:Lamivudine