title: Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands.
abstract: Tetrapeptide derived major histocompatability (MHC) II ligands have been developed that contain no unadulterated peptide bonds. These are the 'least peptidic' ligands for any MHC protein yet reported.
authors.affiliation: Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Jones
authors.forename: J J
authors.initials: JJ
authors.lastname: Acton
authors.forename: A D
authors.initials: AD
authors.lastname: Adams
authors.forename: W
authors.initials: W
authors.lastname: Yuen
authors.forename: E A
authors.initials: EA
authors.lastname: Nichols
authors.forename: C D
authors.initials: CD
authors.lastname: Schwartz
authors.forename: L S
authors.initials: LS
authors.lastname: Wicker
authors.forename: J D
authors.initials: JD
authors.lastname: Hermes
mesh_terms: D015195:Drug Design; D000949:Histocompatibility Antigens Class II / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D007769:Lactams / Q000737:chemistry; D008024:Ligands; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000949:Histocompatibility Antigens Class II; D007769:Lactams; D008024:Ligands; D010455:Peptides