[The effect of thymogen on the postintoxication immunodeficiency state induced by acute acetonitrile poisoning].
It was demonstrated in experiments on Wistar rats that acute acetonitrile (AN) intoxication (0.8L D50) causes decrease of antibody-forming cells in the spleen, mainly those related to the T-dependent antigen, functioning of the natural cell-killers, antibody-dependent cytotoxicity, the ability of macrophages to induce the humoral immune responses and the delayed hypersensitivity reaction. Thymogen restored most of the humoral and cell immune reactions which were reduced by AN.
Zabrodskiĭ
P F
PF
Department of Toxicology, Saratov State Medical University, Russia.
D000097:Acetonitriles / Q000506:poisoning*; D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects; D004151:Dipeptides; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D010455:Peptides / Q000627:therapeutic use*; D011041:Poisoning / Q000150:complications / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000506:poisoning*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D000097:Acetonitriles; D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; D012997:Solvents; C060736:thymogen; C032159:acetonitrile
Vliianie timogena na postintoksikatsionnoe immunodefitsitnoe sostoianie, vyzvannoe ostrym otravleniem atsetonitrilom.