[Role of Ca ions and protein kinase C in the action of vitamin E on respiratory burst of neutrophils and blast transformation of lymphocytes].
It was shown that vitamin E decreased the stimulating role of oxidative burst activators which influenced on Ca(2+)-dependent mechanisms (A23187, verapamil, FMLP). Jointly addition of this vitamin and blood plasma contained tocopherol-binding proteins influenced on mechanisms associated with protein kinase C. It was shown that Ca ions can also take part in tocopherol's action on blast transformation of lymphocytes.
Kapralov
A A
AA
Research Institute of Physiology of Taras Schevchenko Kiev University.
D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D006801:Humans; D007476:Ionophores / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D012016:Reference Values; D016897:Respiratory Burst / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D007476:Ionophores; D014810:Vitamin E; D000001:Calcimycin; D009240:N-Formylmethionine Leucyl-Phenylalanine; D014700:Verapamil; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium
Uchastie ionov Ca i proteinkinazy C v deĭstvii vitamina E na dykhatel'nyĭ vzryv neĭtrofilov i blasttransformatsiiu limfotsitov.