title: Vitamin A toxicity secondary to excessive intake of yellow-green vegetables, liver and laver.
abstract: We report a case of sudden onset of vitamin A poisoning. A 20-year-old Japanese woman had been eating pumpkin and only a very limited amount of other foods on a daily basis for 2 years. She was overly concerned about weight reduction. Aurantiasis cutis and abnormal liver function tests were noted by her family doctor in 1995 when she was 18 years old. At that time, she stopped eating pumpkin. However, she secretly continued an excessive intake of other beta-carotene-rich vegetables, liver and laver for about 2 years. Two and one-half years after being seen by her family physician, she experienced sudden onset of low-grade fever, limb edema, cheilitis, dry skin, and headache. These symptoms worsened daily. A liver needle biopsy was performed, and it showed a normal portal tract along with fat-laden Ito cells in the space of Disse. A final diagnosis of vitamin A poisoning and hepatic injury secondary to an eating disorder was made. Her symptoms and serum beta-carotene levels returned to normal with successful adjustment of her diet.
authors.affiliation: Department of Internal Medicine, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Hosaka
authors.forename: S
authors.initials: S
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Nakabayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Amagasaki
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000818:Animals; D001707:Biopsy, Needle; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D006986:Hypervitaminosis A / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008460:Meat / Q000009:adverse effects*; D017747:Seafood; D012624:Seaweed; D013163:Splenomegaly / Q000139:chemically induced; D014675:Vegetables / Q000009:adverse effects*; D014801:Vitamin A / Q000633:toxicity*
chemical_list: D014801:Vitamin A