title: Positron emission tomography in juvenile Alexander disease.
abstract: A 13-year-old boy with cervical kyphosis was diagnosed as having juvenile Alexander disease because of the typical MRI findings, abnormally elevated alphaB-crystallin and heat shock protein 27 in the cerebrospinal fluid. Positron emission tomography with 18F-fluorodeoxyglucose demonstrated hypometabolism in the frontal white matter corresponding to the areas with leukodystrophy. However, the overlying gray matter preserved normal glucose metabolism.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@med.akita-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Sawaishi
authors.forename: J
authors.initials: J
authors.lastname: Hatazawa
authors.forename: N
authors.initials: N
authors.lastname: Ochi
authors.forename: H
authors.initials: H
authors.lastname: Hirono
authors.forename: T
authors.initials: T
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Okudera
authors.forename: G
authors.initials: G
authors.lastname: Takada
mesh_terms: D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000000981:diagnostic imaging* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008607:Intellectual Disability / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009128:Muscle Spasticity / Q000000981:diagnostic imaging* / Q000473:pathology; D013131:Spine / Q000000981:diagnostic imaging; D013577:Syndrome; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed