AMPA-type glutamate receptor subunits are expressed in the avian cochlear hair cells and ganglion cells.
The cellular localization of AMPA-type glutamate receptor subunits was examined in the pigeon inner ear using subunit specific polyclonal antibodies (GluR1-4). In the auditory ganglion cell bodies immunoreactivity for the subunits GluR2/3 and GluR4, but not for GluR1 was detected. The hair cells showed diffuse immunoreactivity for GluR4. Additionally, immunostaining for the subunits GluR2/3 and GluR4 was present below the hair cells. These results indicate that the AMPA type glutamate receptors play a role in neurotransmission at the hair cell afferent synapse in the avian auditory system.
Reng
D
D
Klinikum der J.W. Goethe Universität, Physiologisches Institut III, Frankfurt/Main, Germany.
Hack
I
I
Müller
M
M
Smolders
J W
JW
D000818:Animals; D000918:Antibody Specificity; D010856:Columbidae; D006198:Hair Cells, Auditory / Q000737:chemistry*; D015151:Immunoblotting; D007150:Immunohistochemistry; D010446:Peptide Fragments / Q000032:analysis*; D011233:Precipitin Tests; D018091:Receptors, AMPA / Q000032:analysis* / Q000737:chemistry; D013136:Spiral Ganglion / Q000737:chemistry* / Q000166:cytology; D009435:Synaptic Transmission / Q000502:physiology
D010446:Peptide Fragments; D018091:Receptors, AMPA