Erythropoietic, neurotrophic, and angiogenic functions of erythropoietin and regulation of erythropoietin production.
Stimulation of erythrocyte formation has been generally thought to be the sole physiological function of erythropoietin. Erythropoietin and its receptors, however, are also expressed in the central nervous system. In addition, erythropoietin is produced in the uterus in an estrogen-dependent manner. Novel functions of erythropoietin in these local sites are presented.
Masuda
S
S
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
Nagao
M
M
Sasaki
R
R
D002490:Central Nervous System / Q000502:physiology; D004921:Erythropoietin / Q000096:biosynthesis / Q000502:physiology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D017467:Receptors, Erythropoietin / Q000502:physiology*; D014599:Uterus / Q000502:physiology
D004967:Estrogens; D017467:Receptors, Erythropoietin; D004921:Erythropoietin