[Serum soluble interleukin-2 receptor in patients with pulmonary mycobacterial diseases].
Serum soluble interleukin-2 receptor (sIL-2R) levels were measured in patients with untreated pulmonary tuberculosis (24 cases), patients with multidrug-resistant intractable pulmonary tuberculosis (7 cases) and patients with pulmonary non-tuberculous mycobacteriosis (27 cases). Serum sIL-2R levels were elevated in patients with pulmonary mycobacterial diseases and were elevated in untreated pulmonary tuberculosis patients than in other patients. In patients with new tuberculosis, serum sIL-2R levels were higher in patients with extensive lesions. Serum sIL-2R level showed significant positive correlation with serum C-reactive protein level and erythrocyte sedimentation rate, and significant negative correlation with serum albumin level. In patients with intractable tuberculosis and patients with non-tuberculous mycobacteriosis, serum sIL-2R levels were lower than in patients with new tuberculosis. Even in patients with extensive lesions, serum sIL-2R levels were not elevated. Lower levels of serum sIL-2R, marker of immunocompetent cell activity, suggested that immunocompetent cell activity was suppressed in intractable tuberculosis and in non-tuberculous mycobacteriosis.
Tada
A
A
Department of Internal Medicine, National Minami-Okayama Hospital, Japan.
Kawahara
S
S
Horita
N
N
Horiba
A
A
Tamaoki
A
A
Okada
C
C
Mishima
Y
Y
Soda
R
R
Takahashi
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000097:blood*; D018088:Tuberculosis, Multidrug-Resistant / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
D015375:Receptors, Interleukin-2