title: GPI-microdomains: a role in signalling via immunoreceptors.
abstract: Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.
authors.affiliation: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, V denská 1083, Czech Republic. horejsi@biomed.cas.cz
authors.forename: V
authors.initials: V
authors.lastname: Horejsí
authors.forename: K
authors.initials: K
authors.lastname: Drbal
authors.forename: M
authors.initials: M
authors.lastname: Cebecauer
authors.forename: J
authors.initials: J
authors.lastname: Cerný
authors.forename: T
authors.initials: T
authors.lastname: Brdicka
authors.forename: P
authors.initials: P
authors.lastname: Angelisová
authors.forename: H
authors.initials: H
authors.lastname: Stockinger
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D017261:Glycosylphosphatidylinositols / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology
chemical_list: D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; D011971:Receptors, Immunologic