title: Synthesis of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides.
abstract: The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.
authors.affiliation: I.C.O.A., associé au CNRS, Faculté des Sciences, Orléans-France.
authors.forename: L A
authors.initials: LA
authors.lastname: Agrofoglio
authors.forename: F
authors.initials: F
authors.lastname: Girard
authors.forename: F
authors.initials: F
authors.lastname: Fleury
authors.forename: S
authors.initials: S
authors.lastname: Léonce
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000473:pathology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D011741:Pyrimidine Nucleosides