title: Cervical secretory immunoglobulin A in adolescent girls.
abstract: OBJECTIVE
  To determine whether there are differences in levels of cervical secretory immunoglobulin A (sIgA) between adolescent girls in the secretory and proliferative phases of their menstrual cycle.
  
  
  METHODS
  Sexually active adolescent girls (n = 117) at health maintenance organization (HMO) based adolescent medical clinic were recruited into the study. In addition to demographic and clinical data, cervical specimens were collected for sIgA measurement and gonorrhea culture, urine for chlamydia ligase chain reaction, and blood for progesterone levels. Subjects were classified as being in the proliferative phase or secretory phase of the menstrual cycle on the basis of their progesterone levels.
  
  
  RESULTS
  The mean age of the subjects was 17.2 years old. There was no difference in the sIgA levels between those in the proliferative phase of their cycle (n = 45; mean sIgA level, 0.0055 mg/mL) and those in the secretory phase (n = 40; mean sIgA level, 0.0032 mg/mL) (p > .10).
  
  
  CONCLUSIONS
  The secretory phase of the menstrual cycle does not appear to be associated with higher levels of sIgA in adolescent girls. These results suggest that adolescents with anovulatory cycles, i.e., those who lack a secretory phase, may not be at increased risk for genital tract infections such as chlamydia or gonorrhea.
authors.affiliation: Department of Pediatrics, University of California, San Francisco, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Ellen
authors.forename: C J
authors.initials: CJ
authors.lastname: Lammel
authors.forename: M A
authors.initials: MA
authors.lastname: Shafer
authors.forename: E
authors.initials: E
authors.lastname: Teitle
authors.forename: J
authors.initials: J
authors.lastname: Schachter
authors.forename: R S
authors.initials: RS
authors.lastname: Stephens
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002584:Cervix Uteri / Q000378:metabolism*; D002690:Chlamydia Infections / Q000276:immunology; D005260:Female; D006069:Gonorrhea / Q000276:immunology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008597:Menstrual Cycle / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D014626:Vaginal Smears
chemical_list: D007071:Immunoglobulin A, Secretory; D011374:Progesterone