Investigations on magnesium and chromium antagonism in the skin of experimental animals.
Investigations were performed over 30 days on 25 male rats Wistar breed divided into five groups. Animals received intraperitoneally (i.p.) potassium dichromate (KDCH) 5 mg/kg (basal doses, b.d.), 2 mg/kg (0.4 b.d.) and 100 mg Mg Cl2/kg body weight (b.w.). In performed investigations the highest concentration of chromium in animal skin 1.17 +/- 0.11 micrograms/g was observed by i.p. administration of KDCH 5 mg/kg b.w. Simultaneous i.p. administration of KDCH 5 mg/kg b.w. and MgCl2 100 mg/kg b.w. resulted in significant lower concentration of chromium (in comparison to the preceding group) in animal skin: 0.8 +/- 0.2 microgram/g (p < 0.001). In i.p. administration of KDCH in the doses of 0.4 b.d. the concentration of Cr in the skin amounted to 0.55 +/- 0.1 microgram/g. Values of Cr in the skin in exposed groups were significantly higher than in the control group, (p < 0.001).
Bulikowski
W
W
Polyclinic of Gniezno Tannery, Poland.
Pietrzak
I
I
Borzecki
A
A
Lingas
W
W
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D002857:Chromium / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008274:Magnesium / Q000032:analysis / Q000378:metabolism*; D015636:Magnesium Chloride / Q000494:pharmacology*; D008297:Male; D011192:Potassium Dichromate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D015636:Magnesium Chloride; D002857:Chromium; D008274:Magnesium; D002118:Calcium; D011192:Potassium Dichromate