Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects.
OBJECTIVE
The present study investigated whether administration of a 5-HT1A receptor agonist would increase growth hormone (GH) and oxytocin levels in normal human subjects, and whether the responses would be modified according to the age and gender of the subjects.


METHODS
Ipsapirone (0.3 mg/kg body weight), or placebo was administered to 30 normal subjects (14 males, 19-74 years and 16 females, 22-69 years) using a randomized, double blind design.


RESULTS
Stimulation of GH secretion by ipsapirone was significantly greater in male compared to female subjects, with no apparent effect of age. Oxytocin secretion was not stimulated by ipsapirone compared to placebo in any of the groups.


CONCLUSIONS
The effects of gender and age on the degree of stimulation of GH secretion by 5-HT1A agonists in human subjects differ from their effects on secretion of the hormones ACTH and cortisol. A higher dose of ipsapirone is required to stimulate oxytocin secretion in normal human subjects.
Newman
M E
ME
Biological Psychiatry Laboratory, Hadassah University Hospital, Jerusalem, Israel. newman@hadassah.org.il
Li
Q
Q
Gelfin
Y
Y
Van de Kar
L D
LD
Lerer
B
B
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D004311:Double-Blind Method; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010121:Oxytocin / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D012737:Sex Factors
D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D010121:Oxytocin; C043077:ipsapirone; D013006:Growth Hormone