title: [Tissue plasminogen activator and diabetes mellitus].
abstract: tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.
authors.affiliation: I. interná klinika MFN, Martin.
authors.forename: P
authors.initials: P
authors.lastname: Galajda
authors.forename: E
authors.initials: E
authors.lastname: Martinka
authors.forename: P
authors.initials: P
authors.lastname: Kubisz
authors.forename: M
authors.initials: M
authors.lastname: Mokán
mesh_terms: D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D010959:Tissue Plasminogen Activator / Q000378:metabolism / Q000502:physiology*
chemical_list: D010959:Tissue Plasminogen Activator
vernacular_title: Tkanivový aktivátor plazminogénu (tPA) a diabetes mellitus.