[Thyroid disorders associated with interferon treatment in patients with chronic viral hepatitis or multiple sclerosis].
BACKGROUND
Alpha and beta interferon (IFN-alpha and beta) treatment is associated with the synthesis of thyroid autoantibodies and the development of autoimmune thyroid diseases.


RESULTS
We have retrospectively evaluated their effect in patients with chronic viral hepatitis (CH) (n = 118) and multiple esclerosis (ME) (n = 10). Thyroid dysfunction has been detected in 7.4% of patients, and seroconversion in 4.7%.


CONCLUSIONS
Pre-treatment antithyroid antibodies do not predispose to altered thyroid function, after IFN therapy; their presence should not contraindicate IFN treatment.
Diago
J I
JI
Secciones de Endocrinología, Hospital Severo Ochoa, Leganés, Madrid. cvazquez@hso.es
del Olmo
D
D
Alcázar
V
V
Martínez de Icaya
P
P
Rodríguez
E
E
Martínez Montiel
P
P
D000208:Acute Disease; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000276:immunology; D000998:Antiviral Agents / Q000009:adverse effects*; D005260:Female; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012189:Retrospective Studies; D013960:Thyroid Function Tests / Q000379:methods; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000998:Antiviral Agents; D016898:Interferon-alpha; D007453:Iodide Peroxidase
Alteraciones tiroideas asociadas al tratamiento con interferón en pacientes con hepatitis crónica viral o esclerosis múltiple.