Chemistry and biological activities of constituents from Morus australis.
A novel constituent named australone B (1) was further isolated from the cortex of Morus australis (Moraceae). The structure of 1 has been elucidated by one- and two-dimension spectra. In human citrated platelet-rich plasma, 1 showed strong inhibition of aggregation induced by adrenaline in a concentration-dependent manner with an IC(50) value of about 33.3 microM. Compound 1 (30 microM) also showed inhibitory effects on superoxide anion formation from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB). Morusin (2) inhibited superoxide anion formation from rat neutrophils stimulated with phorbol myristate acetate (PMA) in a concentration-dependent manner with an IC(50) value of 66.9+/-2.5 microM.
Ko
H H
HH
School of Pharmacy, Kaohsiung Medical College, Kaohsiung, Taiwan.
Wang
J J
JJ
Lin
H C
HC
Wang
J P
JP
Lin
C N
CN
D000818:Animals; D015550:Cell Degranulation; D003571:Cytochalasin B; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013624:Taiwan; D013755:Tetradecanoylphorbol Acetate; D014197:Trees / Q000737:chemistry*
D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; C121339:australone B; D003571:Cytochalasin B; D009240:N-Formylmethionine Leucyl-Phenylalanine; C057451:morusin; D013755:Tetradecanoylphorbol Acetate