Bile acids and lipoprotein metabolism: a renaissance for bile acids in the post-statin era?
Based on an improved molecular understanding of how bile acid metabolism is regulated, an exciting period of research developments can be expected. By new ways of stimulating cholesterol breakdown to bile acids, novel therapeutic principles can be forseen which will further improve our potential for treating and preventing atherosclerosis.
Angelin
B
B
Department of Medicine, Karolinska Institutet at Huddinge University Hospital, Sweden. bo.angelin@medhs.ki.se
Eriksson
M
M
Rudling
M
M
D000375:Aging / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D004764:Enterohepatic Circulation; D004789:Enzyme Activation; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D015228:Hypertriglyceridemia / Q000235:genetics; D008074:Lipoproteins / Q000378:metabolism*; D008286:Malabsorption Syndromes / Q000235:genetics
D001647:Bile Acids and Salts; D008074:Lipoproteins; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase