title: UFT plus calcium folinate plus radiotherapy for recurrent rectal cancer.
abstract: Uracil and tegafur (in a molar ratio of 4:1 [UFT]) plus calcium folinate comprise the components of the oral agent, Orzel, which appears to have activity comparable to intravenously administered 5-fluorouracil. This article describes the design of an open-label, disease-oriented, phase I trial of UFT plus calcium folinate in combination with simultaneous pelvic radiation for recurrent rectal cancer. This trial is designed to determine the maximum tolerated dose and dose-limiting toxicity of this regimen.
authors.affiliation: Department of Radio-Oncology and Radiotherapy, Braunschweig Community Hospital, University of Hannover Medical School, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Hoffmann
authors.forename: M
authors.initials: M
authors.lastname: Schiebe
authors.forename: J
authors.initials: J
authors.lastname: Dethling
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D012449:Safety; D005641:Tegafur / Q000627:therapeutic use; D016896:Treatment Outcome; D014498:Uracil / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin