title: New hexahydrocarbazoles and spiro indoles, and their affinity for D2 dopamine and 5-HT2A serotonin receptors.
abstract: In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3-(dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2 and 5-HT2A receptors.
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Santiago de Compostela, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: X
authors.initials: X
authors.lastname: García-Mera
authors.forename: G
authors.initials: G
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Urrutia
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007650:Ketanserin / Q000493:pharmacokinetics; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics; D013134:Spiperone / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D002227:Carbazoles; D018492:Dopamine Antagonists; D007211:Indoles; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013134:Spiperone; D007650:Ketanserin