[Benzodiazepines metabolism in various models of experimental liver diseases].
The aim of the present paper is to establish possible disturbances in benzodiazepines glucuronidation in two experimental models of liver injury: paracetamol acute intoxication and cholestasis followed by paracetamol acute intoxication. We concluded that, despite the alterations observed in liver microsomal lipid profile, glucuronidation remained similar to controls in paracetamol intoxicated rats. On the contrary, cholestatic animals followed by paracetamol intoxication showed an increment in the glucuronidation of the utilized substrated.
Ghanem
C
C
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires.
Ghisolfi
C
C
Scorticati
C
C
Lemberg
A
A
Perazzo
J C
JC
Bengochea
L
L
D000082:Acetaminophen; D000208:Acute Disease; D018712:Analgesics, Non-Narcotic; D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008107:Liver Diseases / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D001569:Benzodiazepines; D000082:Acetaminophen; D014453:Glucuronosyltransferase
Metabolismo de benzodiacepinas en distintos modelos de hepatopatías experimentales.