title: Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 6-substituted purine and 8-azapurine.
abstract: A series of new one two substituted carbonucleoside analogues (OTC), with the purine and 8-azapurine base linked through a methylene group at the cyclopentane ring, were synthesized and evaluated for their activity against a number of viruses and tumor cells in vitro.
authors.affiliation: Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Santana
authors.forename: M
authors.initials: M
authors.lastname: Teijeira
authors.forename: E
authors.initials: E
authors.lastname: Uriarte
authors.forename: C
authors.initials: C
authors.lastname: Terán
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011684:Purine Nucleosides