title: Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats.
abstract: The mechanism of early pulmonary and systemic haemodynamic response to intravenous infusion of LPS from Escherichia coli was investigated in anesthetised Wistar rats. 10 mg of LPS given at a rate of 4 mg/kg/min but not at a rate of 1 mg/kg/min induced an increase in pulmonary arterial pressure (PAP) and a fall in systemic arterial pressure (SAP). Pretreatment with a PAF receptor antagonist; WEB 2170 (5 and 25 mg/kg) inhibited both PAP and SAP responses to LPS (4 mg/kg/min) while an inhibitor of thromboxane synthesis; Camonagrel (10 and 20 mg/kg) abolished PAP response without a major effect on SAP response to LPS. In conclusion, both PAF and TXA2 mediate LPS induced rise in pulmonary arterial pressure while LPS-induced fall in systemic arterial pressure is mediated by PAF.
authors.affiliation: Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Bocheński
authors.forename: S
authors.initials: S
authors.lastname: Chłopicki
authors.forename: R J
authors.initials: RJ
authors.lastname: Gryglewski
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004926:Escherichia coli; D007189:Indans / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013928:Thromboxane A2 / Q000502:physiology*; D014230:Triazoles / Q000494:pharmacology
chemical_list: D001381:Azepines; D004791:Enzyme Inhibitors; D007189:Indans; D008070:Lipopolysaccharides; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles; D013928:Thromboxane A2; C063964:bepafant; C103583:camonagrel