Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection.
Normal mice inoculated intravenously with 50 microg trehalose-6,6'-dimycolate, a glycolipid component of the cell wall of Mycobacterium, in an oil-in-water emulsion (TDM emulsion) acquired a high resistance to intranasal lethal infection of an influenza virus. In contrast, TDM emulsion-treated T-cell receptor delta gene mutant (TCR delta-/-) mice acquired insufficient resistance against the lethal influenza virus infection. The patterns of insufficient resistance were identical to the results obtained previously with mice which were depleted of T-lymphocytes bearing gammadelta T-cell receptors (gammadelta T-cells) by in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (Hoq et al, J. Gen. Virol. 78: 1597-1603, 1997). These results strongly suggest that the gammadelta T-cells play an important non-specific role in resistance against influenza virus infection.
Hoq
M M
MM
Department of Microbiology, Asahikawa Medical College, Japan.
Suzutani
T
T
Nakaya
K
K
Yoshida
I
I
Ogasawara
M
M
Takeda
Y
Y
Shibaki
T
T
Itohara
S
S
Yamamoto
H
H
Azuma
M
M
D000818:Animals; D003311:Cord Factors / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D019676:Genes, T-Cell Receptor delta; D007113:Immunity, Innate; D009980:Influenza A virus; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D009169:Mycobacterium tuberculosis; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000401:mortality; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
D003311:Cord Factors; D004655:Emulsions