title: Use of antiviral treatment and prophylaxis is unlikely to have a major impact on the prevalence of herpes simplex virus type 2.
abstract: BACKGROUND
  Genital infection with herpes simplex virus (HSV) is common and can cause severe morbidity, over many years in some cases. Aciclovir provides suppressive therapy but there is debate over the effects of its use on the spread of infection.
  
  
  OBJECTIVE
  To explore the influence of the natural history of genital HSV and the impact of antiviral therapy.
  
  
  METHODS
  A simple mathematical model of HSV-2 transmission dynamics was developed, and parameter values estimated from published data.
  
  
  RESULTS
  The relative durations of the risk of transmitting HSV-2 and the duration of therapy generate a non-linear relation between the duration of antiviral therapy and the reduction in prevalence infection. If there is a wide distribution of risk of HSV-2 transmission over the course of an infection then practicable aciclovir use is unlikely to have any great impact on disease transmission dynamics.
  
  
  CONCLUSIONS
  There are still many uncertainties in the transmission dynamics of HSV-2. In particular, infectiousness over the course of an infection requires more detailed exploration. To have a significant impact on the prevalence of HSV-2 aciclovir use would have to be widespread and for a long duration.
authors.affiliation: Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford.
authors.forename: P J
authors.initials: PJ
authors.lastname: White
authors.forename: G P
authors.initials: GP
authors.lastname: Garnett
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000635:transmission; D018258:Herpesvirus 2, Human; D006801:Humans; D008954:Models, Biological; D018570:Risk Assessment; D012747:Sexual Partners
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir