Hyperthermic effect of centrally administered natriuretic peptides in the rat.
The effects of atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32) and C-type natriuretic peptide (CNP-22) on body temperature were investigated in rats. Intracerebroventricular administration of each peptide in doses of 400 or 1000 ng caused a dose-related elevation in colon temperature 30 and 60 min after injection. A 40 ng dose of ANP-28 was also hyperthermic at 60 min. An intramuscular (i.m.) injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the natriuretic peptide-induced hyperthermia. The results show that natriuretic peptides may participate in thermoregulatory processes in the central nervous system, and that their hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.
Pataki
I
I
Department of Pathophysiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Jászberényi
M
M
Telegdy
G
G
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D003106:Colon / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004177:Dipyrone / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D047069:Pyrazolones; D051381:Rats; D017208:Rats, Wistar
D016861:Cyclooxygenase Inhibitors; D009419:Nerve Tissue Proteins; D047069:Pyrazolones; D020097:Natriuretic Peptide, Brain; C076910:brain natriuretic peptide, porcine; D020098:Natriuretic Peptide, C-Type; D004177:Dipyrone; D009320:Atrial Natriuretic Factor; C008667:noramidopyrine