Effects of sodium alginate and fish oil to reduce trichloroethylene accumulation in rats.
This study was conducted to examine the effect of dietary sodium alginate and fish oil on bodily accumulated trichloroethylene (TCE), which has been widely used as a halogenated solvent and is metabolized at a high rate. Each of three groups of rats was fed on either of diets containing cellulose-soybean oil (control), Na-alginate-soybean oil or cellulose-fish oil for 3 wk, and thereafter given a single oral dose of TCE (100 mg (0.76 mmol)/rat). TCE levels in the blood were monitored for 10 h after the administration of TCE. The peak concentrations of TCE in the blood tended to be higher in the alginate and fish oil groups as compared with those in the cellulose-soybean oil group, but not to a significant extent. TCE concentrations in the liver, kidney, brain and the three fat tissues (epididymal, perirenal and subcutaneous) were significantly lower in the alginate and fish oil groups than in the cellulose-soybean oil group. Fat tissue weights were also lower in the alginate group and fish oil group. The hepatic drug metabolizing enzymes could not account for the remarkable decreases of residual TCE contents in the alginate and fish oil groups. These findings indicate that the metabolism and excretion of TCE might be accelerated in animals with reduced fat tissue mass.
Ikegami
S
S
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan.
Umegaki
K
K
D000273:Adipose Tissue / Q000737:chemistry; D000464:Alginates / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001921:Brain; D002482:Cellulose / Q000378:metabolism; D002849:Chromatography, Gas; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004032:Diet; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000032:analysis; D005982:Glutathione Transferase / Q000032:analysis; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012997:Solvents / Q000493:pharmacokinetics*; D013025:Glycine max / Q000502:physiology; D014241:Trichloroethylene / Q000097:blood / Q000493:pharmacokinetics*
D000464:Alginates; D005395:Fish Oils; D012997:Solvents; D014241:Trichloroethylene; D002482:Cellulose; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase