title: Moraxella (Branhamella) catarrhalis BRO beta-lactamase: a lipoprotein of gram-positive origin?
abstract: In the past 20 years, BRO beta-lactamase-producing Moraxella catarrhalis strains have emerged. We show that BRO is expressed as a 33-kDa lipoprotein associated with the inner leaflet of the outer membrane. To our knowledge, this is the first description of a lipidated beta-lactamase in a gram-negative species.
authors.affiliation: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Hospital Utrecht, Utrecht, The Netherlands. H.J.Bootsma@lab.azu.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Bootsma
authors.forename: P C
authors.initials: PC
authors.lastname: Aerts
authors.forename: G
authors.initials: G
authors.lastname: Posthuma
authors.forename: T
authors.initials: T
authors.lastname: Harmsen
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: H
authors.initials: H
authors.lastname: van Dijk
authors.forename: F R
authors.initials: FR
authors.lastname: Mooi
mesh_terms: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis* / Q000276:immunology; D004926:Escherichia coli / Q000201:enzymology / Q000648:ultrastructure; D006094:Gram-Positive Bacteria / Q000737:chemistry*; D007150:Immunohistochemistry; D008074:Lipoproteins / Q000032:analysis / Q000276:immunology; D008854:Microscopy, Electron; D001936:Moraxella catarrhalis / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology; D001618:beta-Lactamases / Q000032:analysis* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins; D001618:beta-Lactamases