(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase.
Aicher
T D
TD
Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901, USA. Thomas.Aicher@pharma.novartis.com
Anderson
R C
RC
Bebernitz
G R
GR
Coppola
G M
GM
Jewell
C F
CF
Knorr
D C
DC
Liu
C
C
Sperbeck
D M
DM
Brand
L J
LJ
Strohschein
R J
RJ
Gao
J
J
Vinluan
C C
CC
Shetty
S S
SS
Dragland
C
C
Kaplan
E L
EL
DelGrande
D
D
Islam
A
A
Liu
X
X
Lozito
R J
RJ
Maniara
W M
WM
Walter
R E
RE
Mann
W R
WR
D000284:Administration, Oral; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005347:Fibroblasts; D006801:Humans; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000378:metabolism; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000577:Amides; D004791:Enzyme Inhibitors; D011422:Propionates; D047428:Protein Kinase Inhibitors; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D019344:Lactic Acid; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases