title: Paget-Schroetter syndrome associated with FV:Q506 and prothrombin 20210A--a case report.
abstract: Effort thrombosis of the axillary-subclavian vein (Paget-Schroetter syndrome) develops usually secondary to heavy arm exertion. An underlying chronic venous compressive anomaly at the thoracic outlet or intimal damage of the axillary vein following forceful hyperabduction, external rotation of the shoulder joint has been proposed to explain the pathophysiology of this thrombosis. This condition is usually not attributed to an underlying hypercoagulability such as deficiency of natural coagulation inhibitors. Here, the authors present a case with thrombosis of the axillary-subclavian vein following an effort, with factor V Leiden and prothrombin 20210A mutations. Both factor V Leiden and the genetic variant in the prothrombin gene have been shown to confer an increased risk for venous thrombosis. Although rare, effort thrombosis may develop in a patient with hereditary thrombophilia, so laboratory evaluation should include the common causes of thrombosis.
authors.affiliation: Department of Hematology, Hacettepe University Medical School, Ankara, Turkey. nsayinal@hacettepe.edu.tr
authors.forename: N
authors.initials: N
authors.lastname: Sayinalp
authors.forename: O I
authors.initials: OI
authors.lastname: Ozcebe
authors.forename: S
authors.initials: S
authors.lastname: Kirazli
authors.forename: R
authors.initials: R
authors.lastname: Doğan
authors.forename: S V
authors.initials: SV
authors.lastname: Dündar
authors.forename: A
authors.initials: A
authors.lastname: Gürgey
mesh_terms: D000328:Adult; D000483:Alleles; D000925:Anticoagulants / Q000627:therapeutic use; D001367:Axillary Vein / Q000000981:diagnostic imaging; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D010690:Phlebography; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011516:Prothrombin / Q000235:genetics* / Q000378:metabolism; D012008:Recurrence; D013350:Subclavian Vein / Q000000981:diagnostic imaging; D013577:Syndrome; D017131:Thrombectomy; D020246:Venous Thrombosis / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin