title: Immune response to pneumococcal conjugate and polysaccharide vaccines in otitis-prone and otitis-free children.
abstract: We compared responses to pneumococcal conjugate and polysaccharide vaccines in 48 otitis-free and 64 otitis-prone children. Pre- and postimmunization concentrations of antibodies to pneumococcal serotypes 6B, 14, 19F, and 23F were measured by enzyme-linked immunosorbent assay. Postimmunization mean concentrations of antibodies to all four serotypes were significantly higher for children receiving conjugate vaccine than for those receiving polysaccharide vaccine; the difference in responses was primarily due to a better response to conjugate vaccine in the otitis-prone group. Significantly higher postimmunization concentrations of antibodies to all four serotypes and to one of the four serotypes were found in otitis-prone children and otitis-free children who received conjugate vaccine, respectively. Pneumococcal conjugate vaccine has the potential to reduce the incidence of disease due to vaccine serotypes, even among children with recurrent otitis media.
authors.affiliation: Maxwell Finland Laboratory for Infectious Diseases, Boston Medical Center, and Boston University School of Public Health, Massachusetts 02118, USA. ebarnett@bu.edu
authors.forename: E D
authors.initials: ED
authors.lastname: Barnett
authors.forename: S I
authors.initials: SI
authors.lastname: Pelton
authors.forename: H J
authors.initials: HJ
authors.lastname: Cabral
authors.forename: R D
authors.initials: RD
authors.lastname: Eavey
authors.forename: C
authors.initials: C
authors.lastname: Allen
authors.forename: M J
authors.initials: MJ
authors.lastname: Cunningham
authors.forename: E R
authors.initials: ER
authors.lastname: McNamara
authors.forename: J O
authors.initials: JO
authors.lastname: Klein
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D008297:Male; D022401:Meningococcal Vaccines; D010033:Otitis Media / Q000276:immunology*; D022242:Pneumococcal Vaccines; D016037:Single-Blind Method; D013296:Streptococcus pneumoniae / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate