title: Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke: a multicenter survey. The t-PA Stroke Survey Group.
abstract: We assessed initial clinical experience with IV tissue plasminogen activator (t-PA) treatment of acute ischemic stroke in a standardized retrospective survey of hospitals with experienced acute stroke treatment systems. The incidence of symptomatic intracerebral hemorrhage (ICH) was 6% (11 of 189 patients; 95% CI 3 to 11%), similar to that in the National Institute of Neurological Disorders and Stroke (NINDS) t-PA Stroke Study. Deviations from the NINDS protocol guidelines were identified in 30% of patients (56 of 189). The incidence of symptomatic ICH was 11% among patients with protocol deviations as compared with 4% in patients who were treated according to the NINDS protocol guidelines, suggesting that strict adherence to protocol guidelines is prudent.
authors.affiliation: Henry Ford Hospital and Health Science Center, Detroit, MI, USA.
authors.forename: D
authors.initials: D
authors.lastname: Tanne
authors.forename: V E
authors.initials: VE
authors.lastname: Bates
authors.forename: P
authors.initials: P
authors.lastname: Verro
authors.forename: S E
authors.initials: SE
authors.lastname: Kasner
authors.forename: J R
authors.initials: JR
authors.lastname: Binder
authors.forename: S C
authors.initials: SC
authors.lastname: Patel
authors.forename: H H
authors.initials: HH
authors.lastname: Mansbach
authors.forename: S
authors.initials: S
authors.lastname: Daley
authors.forename: L R
authors.initials: LR
authors.lastname: Schultz
authors.forename: P N
authors.initials: PN
authors.lastname: Karanjia
authors.forename: P
authors.initials: P
authors.lastname: Scott
authors.forename: J M
authors.initials: JM
authors.lastname: Dayno
authors.forename: K
authors.initials: K
authors.lastname: Vereczkey-Porter
authors.forename: C
authors.initials: C
authors.lastname: Benesch
authors.forename: D
authors.initials: D
authors.lastname: Book
authors.forename: W M
authors.initials: WM
authors.lastname: Coplin
authors.forename: D
authors.initials: D
authors.lastname: Dulli
authors.forename: S R
authors.initials: SR
authors.lastname: Levine
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000628:therapy*; D002561:Cerebrovascular Disorders / Q000628:therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator