title: Development of a high grade dysplastic nodule in a case of congenital hepatic fibrosis.
abstract: A 43-year-old male with a history of congenital hepatic fibrosis associated with large liver cell dysplasia developed a sizable lesion in the right lobe of the liver, which was, after a follow-up of 4 years, surgically removed on account of a suspected malignant transformation. Pathological examination showed an unencapsulated nodule with both architectural and cytological dysplastic changes, arising in a background of congenital hepatic fibrosis harbouring extranodular foci of large liver cell dysplasia. This report concerns the development of a high grade dysplastic nodule, a sizable hepatocellular lesion with suspected preneoplastic significance, in a patient with congenital hepatic fibrosis associated with large liver cell dysplasia.
authors.affiliation: Department of Pathology, University of Milan Medical School, Italy. massimo.roncalli@humanitas.it
authors.forename: M
authors.initials: M
authors.lastname: Roncalli
authors.forename: M
authors.initials: M
authors.lastname: Maggioni
authors.forename: E
authors.initials: E
authors.lastname: Opocher
authors.forename: G
authors.initials: G
authors.lastname: Coggi
mesh_terms: D000328:Adult; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000151:congenital* / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology*