Activity-dependent regulation of interleukin-1 beta immunoreactivity in the developing rat olfactory bulb.
Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on postnatal day 1 and then survived until postnatal day 30. Interleukin-1beta-immunoreactive fibers occupied distinct layers of the olfactory bulb. Dense immunostaining was found in the periglomerular and granule cell layers. Odor deprivation resulted in a noticeable reduction in interleukin-1beta immunoreactivity only in the periglomerular layer. The data demonstrate that interleukin-1beta is present abundantly in the bulbs, and that it can be regulated in an activity-dependent manner.
Lim
J H
JH
University of Virginia, Department of Psychology, Charlottesville 22903, USA.
Brunjes
P C
PC
D000818:Animals; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000378:metabolism*; D009296:Nasal Cavity / Q000502:physiology; D009412:Nerve Fibers / Q000378:metabolism; D009414:Nerve Growth Factors / Q000096:biosynthesis; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D012683:Sensory Deprivation / Q000502:physiology*; D012903:Smell / Q000502:physiology*
D007375:Interleukin-1; D009414:Nerve Growth Factors