Acute trilineage leukemia with monosomy of chromosome 7 following an acute promyelocytic leukemia.
We describe an 8 year old boy who had received chemotherapy for an acute promyelocytic leukemia and developed a secondary leukemia 27 months after the diagnosis of this first malignancy. Blasts cells were positive for cytoplasmic markers CD22, CD3 and myeloperoxidase. Cell surface T and myeloid-associated markers were also detected. Cytogenetic study disclosed monosomy 7. The patient achieved complete remission, but relapsed 15 months later with identical immunophenotypic and cytogenetic findings. Three-lineage commitment is proved by the expression of specific criteria for myeloid, and lymphoid T and B typing. A multipotent immature progenitor must be the target of leukemogenic agents. The prognosis is obviously ominous.
Felice
M S
MS
Department of Hematology-Oncology, Hospital de Pediatria SAMIC Prof. Dr. J P Garrahan, Buenos Aires, Argentina.
Rossi
J
J
Gallego
M
M
Zubizarreta
P A
PA
Cygler
A M
AM
Alfaro
E
E
Sackmann-Muriel
F
F
D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D014408:Biomarkers, Tumor; D017252:CD3 Complex / Q000032:analysis; D015815:Cell Adhesion Molecules; D002648:Child; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D037102:Lectins; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D009006:Monosomy; D009195:Peroxidase / Q000032:analysis; D012008:Recurrence; D051918:Sialic Acid Binding Ig-like Lectin 2
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D014408:Biomarkers, Tumor; C497867:CD22 protein, human; D017252:CD3 Complex; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2; D009195:Peroxidase