Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures.
Serum neuron-specific enolase (s-NSE) and s-100 protein (s-100) are sensitive markers of various brain diseases. We investigated both of these markers in nine patients within 5 min, 6 h, 12 h, and 48 h after a single tonic-clonic seizure. The mean peak s-NSE level was significantly higher after 5 min (11.97 +/- 8.56 microg/l) and 48 h (10.31 +/- 8.92 microg/l, P < 0.05) than the levels of seizure-free, age-matched controls. Five patients had increased s-NSE levels regarding the upper limit of normal as mean + 3 SD. s-100 was not detected either in controls or epileptic patients. These data indicate that s-NSE in contrast to s-100 may be an in vivo marker after generalized seizures in some patients.
Büttner
T
T
Department of Neurology, St. Josef-Hospital, Ruhr University of Bochum, Germany.
Lack
B
B
Jäger
M
M
Wünsche
W
W
Kuhn
W
W
Müller
T
T
Przuntek
H
H
Postert
T
T
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004830:Epilepsy, Tonic-Clonic / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*
D015415:Biomarkers; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase