Lectin production by human T-lymphocytes.
Cultured human peripheral blood monocytes (PBMC) and the cell line H9 release a lectin. This lectin is not the previously described sarcolectin, since it does not specifically recognize the sugars lactose and sialic acid. The lectinic T-cell factor reduces the release by APCs of IFN alpha--a key cytokine known to inhibit the proliferation of activated T-lymphocytes.
Lachgar
A
A
Le Buanec
H
H
Burny
A
A
Bizzini
B
B
Zagury
D
D
D000371:Agglutination; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000938:Antigen-Presenting Cells / Q000378:metabolism; D002460:Cell Line; D016895:Culture Media, Serum-Free; D006801:Humans; D016898:Interferon-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D037102:Lectins / Q000378:metabolism*; D008937:Mitomycins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D016895:Culture Media, Serum-Free; D016898:Interferon-alpha; D037102:Lectins; D008937:Mitomycins