Apicomplexan plastids as drug targets.
Prokaryotic metabolic pathways in the relict plastid of apicomplexan parasites make this organelle a promising target for drug development. The parasiticidal activity of several herbicides and antibacterial antibiotics is suspected to be a result of their ability to inhibit key plastid activities.
McFadden
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Plant Cell Biology Research Center, School of Botany, University of Melbourne, Parkville, VIC 3052, Australia. g.mcgadden@botany.unimelb.edu.au
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D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D016782:Apicomplexa / Q000187:drug effects* / Q000235:genetics*; D006540:Herbicides / Q000494:pharmacology*; D018087:Plastids / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D011528:Protozoan Infections / Q000188:drug therapy / Q000469:parasitology
D000981:Antiprotozoal Agents; D006540:Herbicides