Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid.
A number of semisynthetic analogs of oleanolic acid have been synthesized and tested for their complement inhibitory, cytotoxic and apoptotic activities. Among these, compounds 10 and 17 exhibited complement inhibitory potency superior to oleanolic acid. Both have also shown a moderate improvement in in vitro therapeutic index (T.I.).
Assefa
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H
Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University 38677, USA.
Nimrod
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A
Walker
L
L
Sindelar
R
R
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D003169:Complement Inactivator Proteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D053938:DNA Fragmentation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008545:Melanoma / Q000188:drug therapy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003169:Complement Inactivator Proteins; D009828:Oleanolic Acid