[A case of liver metastases from gastric cancer responding to induced hypertensive chemotherapy with angiotensin II].
A 69-year-old man, who had undergone distal gastrectomy for Borrmann type 3 gastric cancer two years ago, experienced a recurrence of multiple liver metastases. Then intra-arterial hepatic cannulation connecting to a subcutaneously implanted port system was indwelt via left subclavial artery. Mitomycin C (20 mg) was injected through out the induced hypertension (1.5 times of his median blood pressure) with intravenously-administered angiotensin II (Delivert), and 5-FU (250 mg/day) was continuously followed for 5 days. He received a total of five courses of this treatment every 4 to 7 weeks. The liver metastases disappeared on CT scan after 4 courses, and a complete response (CR) has been maintained with no use of other chemotherapy. The patient has obtained good quality of life for 32 months after the start of this chemotherapy. Induced hypertensive chemotherapy could be one of the effective treatments for liver metastases from gastric cancer.
Nakajima
Y
Y
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Kitamura
M
M
Arai
K
K
Iwasaki
Y
Y
D000368:Aged; D000804:Angiotensin II / Q000008:administration & dosage*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D007269:Injections, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D016685:Mitomycin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local; D013274:Stomach Neoplasms / Q000473:pathology*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D016685:Mitomycin; D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate