title: Acute cerebral infarction: quantification of spin-density and T2 shine-through phenomena on diffusion-weighted MR images.
abstract: OBJECTIVE
  To quantify the relative contributions of spin density and T2 effects ("shine through") on diffusion-weighted (DW) magnetic resonance (MR) images of acute and subacute cerebral infarction.
  
  
  METHODS
  In 30 patients, 1.5-T imaging was performed within the first 7 days after onset of cerebral infarction. Estimates of T2, spin density, and apparent diffusion coefficient (ADC) in the region of stroke and contralateral normal brain were computed by means of standard regression techniques after quadruple-echo conventional MR imaging and single-shot echo-planar DW imaging with a maximum b value of 1,000 sec/mm2. Expected signal intensity (S) enhancement ratios resulting from independent changes in T2, spin density, and ADC were then calculated for the DW sequence.
  
  
  RESULTS
  The overall SI of cerebral infarction on DW images was significantly higher than that of normal brain throughout the 1st week after stroke (mean relative SI enhancement ratio, 2.29; P < .001). During the first 2 days after stroke, decreased ADC within the stroke region made the dominant contribution to increased SI on DW images. By day 3, increased T2 values in the stroke region became equally important, and, from days 3-7, the contribution to SI from T2 effects became dominant. A slight increase of spin density in the stroke region made a relatively small and constant contribution to DW SI over the 1st week.
  
  
  CONCLUSIONS
  The increased SI of subacute cerebral infarction on DW images reflects not only a shortening of ADC but a prolongation of T2 and spin-density values.
authors.affiliation: Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. jburdett@rad.wfubmc.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Burdette
authors.forename: A D
authors.initials: AD
authors.lastname: Elster
authors.forename: P E
authors.initials: PE
authors.lastname: Ricci
mesh_terms: D000208:Acute Disease; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002544:Cerebral Infarction / Q000175:diagnosis*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D013997:Time Factors