Toxicity of fatty acid 18:5n3 from Gymnodinium cf. mikimotoi: I. Morphological and biochemical aspects on Dicentrarchus labrax gills and intestine.
We present evidence for the toxic effects of fatty acid 18:5n3 (octadecapentaenoic acid) in the gills and intestine of the sea bass Dicentrarchus labrax. Light microscopic observation of gills showed strong mucus production and alteration of ionocytes. The Mg- and Na,K-ATPase activities were inhibited, with IC50 values of 10(-3) and 1.6 x 10(-4) M, respectively. Results are discussed in relation to osmoregulation.
Sola
F
F
LPTE, Université de Nice-Sophia Antipolis, France. sola@unice.fr
Masoni
A
A
Fossat
B
B
Porthé-Nibelle
J
J
Gentien
P
P
Bodennec
G
G
D000818:Animals; D001492:Bass / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase / Q000037:antagonists & inhibitors; D004141:Dinoflagellida / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000633:toxicity; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000633:toxicity*; D005880:Gills / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007422:Intestines / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D005231:Fatty Acids, Unsaturated; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase