title: Plant-based production of xenogenic proteins.
abstract: Foreign protein production in transgenic plants has been successful, from the generation of transgenic plant lines to the marketing of purified proteins. Antigenic proteins from disease organisms, monoclonal antibodies raised against antigens of disease organisms, and proteins with industrial process applications have been produced and tested. For vaccines, clinical trials in humans and feeding trials in animals are in progress to demonstrate their efficacy. For industrial proteins, high expression and downstream processing efficiency are key concerns, with application and test market trials in progress.
authors.affiliation: Cell Biology, ProdiGene, 101 Gateway Boulevard, Suite 100, College Station, TX 77845, USA. eehood@prodigene.com
authors.forename: E E
authors.initials: EE
authors.lastname: Hood
authors.forename: J M
authors.initials: JM
authors.lastname: Jilka
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000235:genetics; D001709:Biotechnology; D004798:Enzymes / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D030821:Plants, Genetically Modified / Q000235:genetics*; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics* / Q000302:isolation & purification; D014614:Vaccines, Synthetic / Q000096:biosynthesis / Q000235:genetics
chemical_list: D004798:Enzymes; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic