title: Surgical removal of subfoveal choroidal neovascular membranes in high myopia.
abstract: BACKGROUND
  A study was carried out to elucidate the anatomical and functional outcome after surgical excision of subfoveal choroidal neovascular membranes in high myopia.
  
  
  METHODS
  Sixty-five patients with high myopia (> or =6 diopters), well-defined subfoveal neovascular membranes on fluorescein angiography and preoperative visual acuity < or =20/100 were selected for surgery. A standardized surgical technique was used in all cases, by a single surgeon. The main outcomes assessed were Snellen visual acuity, surgical retinal pigment epithelium defect and postoperative perfusion of the choriocapillaris. Multifactor analysis of variance and chi-square/Fisher's exact test statistics were used to assess the association between patients' pre- and postoperative characteristics and outcome measures.
  
  
  RESULTS
  Follow-up ranged from 6 to 48 months (mean 16 months). Mean postoperative visual acuity (0.18) was significantly better than mean preoperative visual acuity (0.09). Visual acuity improved by at least two lines in 29 eyes (45%) and was unchanged in 24 (37%). Overall, 43 eyes (66%) had visual acuity of 20/200 or better and 15 (23%), 20/60 or better. Predictive factors with a significant effect on final visual acuity were mean visual acuity, preoperative status of retinal pigment epithelium and postoperative perfusion of the choriocapillaris. Postoperative perfusion was detected in 31 (48%) of the total 65 eyes and in 12 (67%) of the 18 eyes with normal retinal pigment epithelium at baseline. The mean postoperative retinal pigment epithelium defect was 4.6 times larger than the original neovascular membrane. In selected patients, SLO macular scotometry showed areas of retained retinal sensitivity within the atrophic scar.
  
  
  CONCLUSIONS
  The natural history of subfoveal neovascularization in high myopia is rarely visually restorative. By contrast, surgical excision of the membranes is feasible and may restore visual acuity in selected patients. This therapeutic approach merits a formal multicenter clinical trial.
authors.affiliation: Department of Ophthalmology, Institute of Biomedical Sciences, University of Milan, San Gerardo Hospital, Monza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bottoni
authors.forename: E
authors.initials: E
authors.lastname: Perego
authors.forename: P
authors.initials: P
authors.lastname: Airaghi
authors.forename: M
authors.initials: M
authors.lastname: Cigada
authors.forename: S
authors.initials: S
authors.lastname: Ortolina
authors.forename: G
authors.initials: G
authors.lastname: Carlevaro
authors.forename: V
authors.initials: V
authors.lastname: De Molfetta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply; D020256:Choroidal Neovascularization / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000098:blood supply / Q000502:physiology; D006801:Humans; D008297:Male; D008566:Membranes / Q000098:blood supply / Q000601:surgery; D008875:Middle Aged; D009216:Myopia / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012607:Scotoma / Q000150:complications; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology