title: Haemolytic-uraemic syndrome caused by vero toxin-producing Escherichia coli serotype Rough: K-: H49.
abstract: The first case of haemolytic-uraemic syndrome (HUS) caused by Vero toxin-producing Escherichia coli (VTEC) which belonged to a novel serotype, Rough: K-: H49, is reported. The case was initially diagnosed as nephropathia epidemica caused by Puumala virus, but the subsequent diagnosis of HUS caused by VTEC was made after bacteriological investigation. The strain isolated fermented sorbitol produced VT2 toxin but not enterohaemolysin, nor did it carry the eaeA gene. In VTEC strains, the O antigen, the eaeA gene and enterohaemolysin production have been characterized as virulence-associated factors and believed to have an effect on pathogenesis of these strains to cause haemorrhagic colitis or HUS. The findings of this study demonstrate that there is a need for further studies to evaluate the pathogenetic mechanism of VTEC and need for easy diagnostic methods exploiting other properties than O157 antigen and non-fermentation of sorbitol to find all VTEC in human infections.
authors.affiliation: National Public Health Institute, Laboratory of Enteric Pathogens, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Keskimäki
authors.forename: Y
authors.initials: Y
authors.lastname: Ratiner
authors.forename: S
authors.initials: S
authors.lastname: Oinonen
authors.forename: E
authors.initials: E
authors.lastname: Leijala
authors.forename: M
authors.initials: M
authors.lastname: Nurminen
authors.forename: M
authors.initials: M
authors.lastname: Saari
authors.forename: A
authors.initials: A
authors.lastname: Siitonen
mesh_terms: D000328:Adult; D001427:Bacterial Toxins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000145:classification / Q000302:isolation & purification* / Q000378:metabolism; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000382:microbiology*; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000382:microbiology*; D006801:Humans; D008297:Male; D012703:Serotyping; D022641:Shiga Toxin 2
chemical_list: D001427:Bacterial Toxins; D022641:Shiga Toxin 2