title: [Effects of inspiratory muscle training on the oxygen cost of breathing in patients with chronic obstructive pulmonary disease].
abstract: BACKGROUND
  Patients with chronic obstructive pulmonary disease have an increased inspiratory work, since they must overcome high loads due to increased airway resistance.
  
  
  OBJECTIVE
  To determine if the reduction in the metabolic cost of exercise observed in patients with chronic obstructive pulmonary disease (COPD) after inspiratory muscle training, was due to a reduction in the oxygen cost of breathing.
  
  
  METHODS
  Nine patients with COPD (FEV1 39 +/- 13%) subjected to inspiratory muscle training, using a training load of 30% of maximal inspiratory pressure, during 10 weeks; 5 patients with COPD (FEV1 44 +/- 18%) not subjected to training, and 7 healthy controls (FEV1 110 +/- 10%) were studied. The cost of breathing was calculated as the difference in VO2 measured at rest and after breathing a gas mixture containing air and 5% CO2. Exercise VO2 was measured at submaximal exercise.
  
  
  RESULTS
  Oxygen cost of breathing was increased in patients with COPD and it was inversely correlated with FEV1 (r = -0.86 p < 0.001). Inspiratory muscle training increased maximal inspiratory pressure and decreased exercise VO2. Oxygen cost of breathing increased in six and decreased in three trained patients. Changes in this parameter after training did not correlate with the reduction in exercise VO2 or the increment in maximal inspiratory pressure.
  
  
  CONCLUSIONS
  The reduction in exercise VO2 after inspiratory muscle training is not due to a reduction in the oxygen cost of breathing.
authors.affiliation: Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile.
authors.forename: J I
authors.initials: JI
authors.lastname: Quintero
authors.forename: G
authors.initials: G
authors.lastname: Borzone
authors.forename: A
authors.initials: A
authors.lastname: Leiva
authors.forename: C
authors.initials: C
authors.lastname: Villafranca
authors.forename: C
authors.initials: C
authors.lastname: Lisboa
mesh_terms: D000368:Aged; D001945:Breathing Exercises; D005080:Exercise Test; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000503:physiopathology*
vernacular_title: Efecto del entrenamiento muscular inspiratorio en el costo de oxígeno de la ventilación en pacientes con enfermedad pulmonar obstructiva crónica.