title: Unexpected MR-T1 enhancement of endocrine liver metastases with mangafodipir.
abstract: With the use of available liver magnetic resonance contrast agents, such as mangafodipir (Mn-DPDP), liver metastases do not exhibit enhancement on T1-weighted images. This absence of enhancement is due to the lack of hepatocytes within these tumors. The purpose of this report is to demonstrate an unexpected enhancement on T1-weighted images 30 minutes after injection of mangafodipir, in the case of endocrine liver metastases from a non-hyperfunctioning neuroendocrine pancreatic tumor. Different hypotheses could explain this unexpected enhancement, such as increased arterial tumoral flow or high metabolic activity. Contrary to liver metastases of other origins, Mn-DPDP enhancement can be present in neuroendocrine metastases. J. Magn. Reson. Imaging 1999;10:193-195.
authors.affiliation: Department of Radiology, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris 12. 94010 Créteil, France. dmatheiu@univ-paris12.fr
authors.forename: D
authors.initials: D
authors.lastname: Mathieu
authors.forename: C
authors.initials: C
authors.lastname: Coffin
authors.forename: H
authors.initials: H
authors.lastname: Kobeiter
authors.forename: F
authors.initials: F
authors.lastname: Caseiro-Alves
authors.forename: A
authors.initials: A
authors.lastname: Mahfouz
authors.forename: A
authors.initials: A
authors.lastname: Rahmouni
authors.forename: T
authors.initials: T
authors.lastname: Diche
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis / Q000473:pathology; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology; D011300:Preoperative Care; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid