[The effect of bromantane on the behavior of inbred mouse strains with different phenotypes of emotional stress reaction].
Per os administration of bromantan (2-[n-bromphenyl]-aminoadamantan) in doses of 40-50 mg/kg prevents the fixed posture reaction and reduces the level of defecation in Balb/c mice in the "open field" test and activates their behavior in the "elevated plus maze" test. It increases the motor activity of C57B1/c mice in both tests. It is concluded that an anxiolytic effect is present in the spectrum of pharmacological properties of bromantan.
Seredenin
S B
SB
Laboratory of Pharmacogenetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Miramedova
A G
AG
Kozlovskaia
M M
MM
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology*; D008810:Mice, Inbred C57BL / Q000502:physiology*; D010641:Phenotype; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013315:Stress, Psychological / Q000235:genetics / Q000503:physiopathology*
D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane
Vliianie bromantana na povedenie inbrednykh liniĭ mysheĭ s razlichnymi fenotipami émotsional'no-stressovoĭ reaktsii.