title: Psychopathology and substance-related problems during early adolescence: a survival analysis.
abstract: Examined the chronological and statistical relations among onsets of psychopathology, alcohol and cannabis use, and substance-related problem psychopathology, alcohol and cannabis use, and substance-related problems from late childhood through early adolescence in boys of fathers with substance use disorder (SUD; high average risk: n = 177) and without SUD (low average risk: n = 203) using survival analysis. Proportional hazard models indicated that antisocial disorders were predicted by risk group and mediated the observed relation between risk group and substance-related problems. Negative affect disorders were predicted by risk group but did not predict substance involvement in early adolescence. Results support a model in which paternal SUD predisposes to increased antisocial and negative affect disorders in boys, and antisocial disorders lead to substance-related problems in early adolescence.
authors.affiliation: Center for Education and Drug Abuse Research, University of Pittsburgh, PA 15213, USA. clark@paarc00.wpic.pitt.edu
authors.forename: D B
authors.initials: DB
authors.lastname: Clark
authors.forename: A M
authors.initials: AM
authors.lastname: Parker
authors.forename: K G
authors.initials: KG
authors.lastname: Lynch
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000150:complications* / Q000523:psychology; D002648:Child; D005219:Father-Child Relations; D006801:Humans; D008297:Male; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000209:etiology* / Q000523:psychology