GPI-microdomains: a role in signalling via immunoreceptors.
Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.
Horejsí
V
V
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, V denská 1083, Czech Republic. horejsi@biomed.cas.cz
Drbal
K
K
Cebecauer
M
M
Cerný
J
J
Brdicka
T
T
Angelisová
P
P
Stockinger
H
H
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D017261:Glycosylphosphatidylinositols / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology
D017261:Glycosylphosphatidylinositols; D008565:Membrane Proteins; D011971:Receptors, Immunologic