title: [Trends of antidiabetic drug prescriptions in Andalucia (1986-1994)].
abstract: OBJECTIVE
  Tendencies in the consumption of antidiabetic agents in Andalusia between 1986-1994 were analysed, with special emphasis on the impact of the introduction of acarbose and mechanized systems for the injection of insulin.
  
  
  METHODS
  The information concerning consumption was obtained from the data bases of the Andalusian Health Service and the Ministry of Health which contain details of the items sold in community chemists and charged to the National Health System. Data are expressed as defined daily doses per 1000 inhabitants per day (DID).
  
  
  RESULTS
  Insulin consumption rose from 4.67 DID in 1986 to 9.33 DID en 1994, an increase (delta) of 99.8%. All types of insulins contributed to the increase, with the mixtures rising most (delta 275%). Intermediate insulins were the most used. Prefilled syringes accounted for 25% of all insulin dispensed in 1994. Consumption of oral antidiabetic agents (OAA) rose from 12.75 DID in 1986 to 20.92 DID in 1994 (delta 64%). The most prescribed OAAs during these years were second generation sulphonylureas, representing 83% of those dispensed in 1994, followed by acarbose (11%), biguanides (3.8%), and first generation sulphonylureas (2.1%).
  
  
  CONCLUSIONS
  There was a notable increase in the consumption of insulins and OAAs. Although the tendency in the consumption differs from that expected according to consensus agreements, qualitative changes were seen, suggesting an improvement in prescription habits. The appearance of mechanized injection systems for insulin and of acarbose have clearly modified prescription habits.
authors.affiliation: Hospital Universitario Puerta del Mar, Cádiz.
authors.forename: G
authors.initials: G
authors.lastname: Olveira
authors.forename: F
authors.initials: F
authors.lastname: Soriguer
authors.forename: F
authors.initials: F
authors.lastname: Vázquez
authors.forename: S
authors.initials: S
authors.lastname: González-Romero
authors.forename: S
authors.initials: S
authors.lastname: Ruiz de Adana
authors.forename: M
authors.initials: M
authors.lastname: Aguilar
mesh_terms: D011307:Drug Prescriptions / Q000706:statistics & numerical data; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D013030:Spain
chemical_list: D007004:Hypoglycemic Agents
vernacular_title: Tendencias de prescripción de medicamentos antidiabéticos en Andalucía (1986-1994).