[Significance of free radicals in the pathogenesis of rheumatic diseases and possibilities of decreasing their pathogenic effects].
The authors present the result of their work where they provide evidence that in inflammatory and degenerative diseases the break-down on superoxide in inadequate. This oxygen radicals and its metabolites play a significant role in the pathogenesis of these diseases. The authors revealed a severe defect in superoxide degeneration in particular in articular exudates of patients with active synovitis. Administration of the preparation Selzink-Plus of PRO.MED.CS Co. Prague which contains selenium, zinc, beta-cyrotene, vitamin C and E along with antirheumatic treatment improves according to the authors the breakdown of superoxide and its metabolites and improves thus the patient's prognosis. Long-term administration of the preparation seems to produce even better results.
Kucera
M
M
Revmatologická ordinace nemocnice MUDr. Mulace, Plzen.
Racek
J
J
Holecek
V
V
Trefil
L
L
D001168:Arthritis / Q000503:physiopathology*; D004338:Drug Combinations; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D012643:Selenium / Q000627:therapeutic use; D013481:Superoxides / Q000378:metabolism; D014815:Vitamins / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use
D004338:Drug Combinations; D005609:Free Radicals; D014815:Vitamins; D013481:Superoxides; D012643:Selenium; D015032:Zinc
Význam volných radikálů v patogenezi revmatických chorob a moznosti snízení jejich patogenního působení.