Is lithium able to reverse neurological damage induced by vinca alkaloids? (Short communication).
Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.
Petrini
M
M
Oncology Department, University of Pisa, Italy.
Vaglini
F
F
Cervetti
G
G
Cavalletti
M
M
Sartucci
F
F
Murri
L
L
Corsini
G U
GU
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D016651:Lithium Carbonate / Q000494:pharmacology* / Q000627:therapeutic use*; D008223:Lymphoma / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000188:drug therapy*; D051379:Mice; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy; D009498:Neurotoxins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D017933:Peripheral Nervous System / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000633:toxicity*
D009498:Neurotoxins; D016651:Lithium Carbonate; D014750:Vincristine