Immunopharmacology: anti-inflammatory therapy targeting transcription factors.
Immunopharmacology is one of the most dynamic areas in pharmacology encompassing classical immunosuppressive drugs which reveal completely new clues concerning their mode of action as well as novel molecular biology approaches for treating inflammatory and autoimmune diseases, infections and cancer. This article focuses on transcription factors that regulate cell activities involved in immune and inflammatory cell responses and how traditional anti-inflammatory compounds such as glucocorticoids, cyclosporins, tacrolismus and salicylates interfere with the activation cascades triggering the transcription factors. Moreover, promising new initiatives for selective therapeutics including recombinant anti-inflammatory cytokines and proinflammatory cytokine antagonists, and gene therapy will be presented.
Pfeilschifter
J
J
Zentrum der Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfort on the Main, Germany. pfeilschifter@em.uni-frankfurt.de
Mühl
H
H
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods*; D007107:Immune System / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy*; D014157:Transcription Factors / Q000187:drug effects* / Q000235:genetics
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D014157:Transcription Factors