title: ent-kaurane diterpenoids from Isodon lungshengensis.
abstract: Six new ent-kaurane diterpenoids, lungshengenins B-G (1-6), together with three known diterpenoids, lungshengenin A (7), inflexin (8), and lushanrubescinsin C (9), were isolated from the leaves and tender branches of Isodon lungshengensis. Their structures were elucidated by means of spectroscopy, mainly 1D and 2D NMR techniques. Lungshengenins A (7), C (2), and G (6) were cytotoxic toward K562 cells, having IC(50) values equal to or less than 10 microg/mL.
authors.affiliation: Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming, 650204, Yunnan, China.
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Lu
authors.forename: A J
authors.initials: AJ
authors.lastname: Hou
authors.forename: Q S
authors.initials: QS
authors.lastname: Zhao
authors.forename: H D
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes