[Clinico-radiobiological evaluation of radiation dosage and complications of radiotherapy for endometrial neoplasm metastasis to the vagina].
The data on 132 patients with metastases of endometrial carcinoma into the vagina (MECV) were analysed. They had received complex (remote + contact) and contact radiotherapy alone with low-, medium- and high dosage. The following radiobiological models were employed to assess tissue response: time-dose-fractionation factor (TDFF), cumulative radiation effect (CRE) and linear-quadratic dose effect equation (LQDE) ("extrapolated dose of response"). There was no correlation between survival and dose in excess of connective tissue tolerance calculated for each radiobiological model or a dose below tolerance limit. When dosage exceeded tolerance limit the incidence of early- and late-onset radiation injuries increased significantly. In MECV patients who had received primarily radiotherapy and surgery, early-onset radiation injuries occurred in cases of overdosage from the most recent exposure. When high-dose brachiatherapy was employed as a component of complex treatment, late-onset moist epithelite of the vagina could develop, irrespective of whether radiotherapy had been given or not and whether tolerance limit had been exceeded. Late-onset injuries were recorded in cases of over-dosage who had received both radiation and surgery for primary endometrial carcinoma.
Kanaev
S V
SV
Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Turkevich
V G
VG
D001918:Brachytherapy / Q000009:adverse effects; D003556:Cystitis / Q000209:etiology; D004307:Dose-Response Relationship, Radiation; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D004751:Enteritis / Q000209:etiology; D005260:Female; D006801:Humans; D008954:Models, Biological; D011349:Proctitis / Q000209:etiology; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D013997:Time Factors; D014625:Vaginal Neoplasms / Q000532:radiotherapy* / Q000556:secondary*
Kliniko-radiobiologicheskaia otsenka velichiny luchevykh nagruzok i oslozhneniĭ pri radioterapii metastazov raka tela matki vo vlagalishche.