title: Large-scale gene expression data analysis: a new challenge to computational biologists.
abstract: The use of high-density DNA arrays to monitor gene expression at a genome-wide scale constitutes a fundamental advance in biology. In particular, the expression pattern of all genes in Saccharomyces cerevisiae can be interrogated using microarray analysis where cDNAs are hybridized to an array of each of the approximately 6000 genes in the yeast genome. In this survey I review three recent experiments related to transcriptional regulation and discuss the great challenge for computational biologists trying to extract functional information from such large-scale gene expression data.
authors.affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. mzhang@cshl.org
authors.forename: M Q
authors.initials: MQ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D018076:DNA, Complementary / Q000032:analysis; D015870:Gene Expression; D015698:Genomic Library; D006801:Humans; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D018076:DNA, Complementary