Therapeutic cloning: needs and prospects.
There has been widespread speculation regarding the possibility of reprogramming human somatic nuclei by transfer into oocytes. Stem cells derived from such reconstructed embryos could theoretically provide a source of autologous tissue for therapeutic transplantation. However the biological, technical and ethical hurdles which must be overcome before this can be realised are considerable. Here we review the background and prospects for such work.
Kind
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PPL Therapeutics, Roslin, Midlothian, Edinburgh, EH25 9PP, Scotland,
Colman
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D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D002455:Cell Division; D017690:Cell Transplantation / Q000379:methods*; D002999:Clone Cells / Q000637:transplantation*; D019976:Cloning, Organism / Q000639:trends*; D004622:Embryo, Mammalian / Q000166:cytology; D000882:Haplorhini; D006801:Humans; D051379:Mice; D053652:Nuclear Transfer Techniques; D009865:Oocytes / Q000166:cytology; D012756:Sheep; D033581:Stem Cell Transplantation; D013552:Swine; D014183:Transplantation, Heterologous