[Experimental study on the efficacy of methyl prednisolone in the treatment of traction injury of spinal cord in rabbits].
In order to study the prophylactic and therapeutic effect of methyl-prednisolone (MP) on traction injury of spinal cord, 48 rabbits were divided into four groups randomly. According to decreasing amount of the amplitude of P1-wave, 50% reduction lasted for 5 min and 10 min with MP as experimental group, and 50% 5 min and 10 min with NS as control, the changes of amplitudes were monitored by, and the function of the spinal cord was assessed. The amounts of MDA and SOD of the spinal cord tissue were determined and the pathomorphological changes of the spinal cord were observed. The results showed that in the experimental groups, the recovery of P1-wave was quicker, the Tarlov and Molt value were decreased, the density of gray matter of the anterior horn and the myelinated nerve fiber of white matter of 100 microns diameter were higher, the SOD and MDA was decreased and the degenerative and necrotic degree of neuron and nerve fiber were milder. Where in the control groups all the above items were just on the opposite. The conclusions list as follows: the application of MP before operation of spinal deformity might prevent traction injury of the spinal cord during operative correction of spinal deformity, and could also minimized the secondary damage to spinal cord from traction injury if MP was used in time. The action to MP were summarized as improving the microcirculation, inhibiting the hyperoxidation of lipid and accelerating the recovery of SCEP.
Song
Y
Y
Department of Orthopedic Surgery, 1st University Hospital, West China University of Medical Sciences, Chengdu, P.R. China.
Yang
Z
Z
Lei
J
J
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005073:Evoked Potentials, Somatosensory; D008775:Methylprednisolone / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000209:etiology / Q000517:prevention & control*; D014143:Traction
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone