title: [Myocardial revascularization in patients with severely depressed left ventricular function].
abstract: BACKGROUND
  Improvements in anesthetic and surgical management of patients with left ventricular dysfunction have resulted in a decline in perioperative mortality and morbidity. Nevertheless, coronary artery bypass grafting (CABG) in patients with left ventricular ejection fraction < or = 0.30 remains a surgical challenge.
  
  
  METHODS
  Fifty-one patients with end-stage coronary artery disease and left ventricular ejection fraction between 16 and 30% underwent CABG. Mean age at operation was 66.1 +/- 7.85 years. Selection criteria included the clinical diagnosis of ischemic heart disease with angiographic demonstration of critical coronary artery obstructive lesions. Mean number of grafts per patient was 2.94 (range 1-5). Average duration of cardiopulmonary bypass was 74.5 +/- 22.4 min and mean aortic cross clamp time was 47.6 +/- 17 min.
  
  
  RESULTS
  No operative and in-hospital deaths occurred. Eight patients (15.7%) had postoperative low cardiac output syndrome, requiring intraaortic balloon counterpulsation. There were two major neurological complications (3.9%). There were four late deaths (7.8%), due to recurrence of untreatable congestive heart failure. Left ventricular ejection fraction increased from a mean of 25.51 +/- 4.75% preoperatively to 31.35 +/- 9.9% postoperatively (p < 0.001). Improvement in NYHA functional class (preoperatively 2.98 +/- 0.79 vs 2.35 +/- 0.6 postoperatively, p < 0.001) was found in this group at follow-up.
  
  
  CONCLUSIONS
  CABG leads to an excellent prognosis in high risk patients with ischemic heart disease and low left ventricular ejection fraction, improving their functional and clinical outcome and consequently their life expectancy.
authors.affiliation: Unità Operativa di Cardiochirurgia, Istituto Clinico Humanitas, Rozzano, MI.
authors.forename: F
authors.initials: F
authors.lastname: Nicolini
authors.forename: A
authors.initials: A
authors.lastname: Carcagnì
authors.forename: E
authors.initials: E
authors.lastname: Citterio
authors.forename: G
authors.initials: G
authors.lastname: Franciosi
authors.forename: D
authors.initials: D
authors.lastname: Gastaldi
authors.forename: M
authors.initials: M
authors.lastname: Longo
authors.forename: E
authors.initials: E
authors.lastname: Manasse
authors.forename: A
authors.initials: A
authors.lastname: Bandera
authors.forename: R
authors.initials: R
authors.lastname: Gallotti
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D012720:Severity of Illness Index; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000601:surgery*
vernacular_title: La rivascolarizzazione miocardica nei pazienti con funzione ventricolare sinistra severamente depressa.