Leptin in renal failure.
Leptin, an adipocyte-derived hormone, signals to the brain information on the amount of energy stored in adipose tissue and regulates energy homeostasis. In addition, leptin has been implicated in the regulation of neuroendocrine function, growth, hematopoiesis, and immune regulation. Plasma leptin is cleared by the kidney, and thus, leptin levels are elevated in hemodialysis patients. Whether the elevated leptin levels in hemodialysis patients contribute to the pathophysiology of the clinical manifestations of renal failure in humans remains to be conclusively shown in the future.
Mantzoros
C S
CS
Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D020738:Leptin; D011506:Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D006435:Renal Dialysis
D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin