title: Synthesis of new fluorescent nucleoside analogues and application to the study of human deoxycytidine kinase.
abstract: We have determined the affinity of human deoxycytidine kinase with respect to new fluorescent N-methylanthraniloyl cytidine derivatives or non fluorescent enantiomeric cytidine analogues. New results regarding the enantioselectivity and the mechanism of the enzyme are presented.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR 5625 du CNRS, Université Montpellier II, France.
authors.forename: M
authors.initials: M
authors.lastname: Shafiee
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: G
authors.initials: G
authors.lastname: Maury
mesh_terms: D003842:Deoxycytidine Kinase / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000378:metabolism*; D006801:Humans; D009705:Nucleosides / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009705:Nucleosides; D003842:Deoxycytidine Kinase