title: Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients.
abstract: OBJECTIVE
  Infection with Helicobacter pylori is associated with gastric cancer. However, a hereditary risk of gastric cancer has also been reported. Hence, we decided to evaluate H. pylori gastritis in relatives of gastric cancer patients in comparison with matched controls.
  
  
  METHODS
  Case-controlled study.
  
  
  METHODS
  A total of 237 patients with merely H. pylori gastritis (i.e. not associated with either peptic ulcer or gastric malignancy), and either first-degree (93.7%) or second-degree (6.3%) relatives with gastric cancer, were age- and sex-matched with 237 patients with H. pylori gastritis unassociated with a family history of gastric cancer. From each patient, antral and corpus biopsy specimens were obtained and investigated for degree (lymphocyte/plasma cell infiltration) and activity (polymorph infiltration) of gastritis (score: 0-4). Intestinal metaplasia was recorded as present or absent.
  
  
  RESULTS
  The results show that relatives of gastric cancer patients have a significantly greater expression of gastritis due to a higher grade of gastritis in the antrum and corpus (P < 0.0001) and a greater activity of gastritis in the corpus (P < 0.0001). Intestinal metaplasia occurs more often in relatives of gastric cancer patients (antrum: P < 0.0001; corpus: P = 0.0237).
  
  
  CONCLUSIONS
  Since the grade of H. pylori gastritis in relatives of gastric cancer patients is significantly higher than in controls, there appears to be a genetic susceptibility influencing the expression of H. pylori gastritis.
authors.affiliation: Department of Medicine II, Klinikum rechts der Isar, Technical University of Munich, Germany.
authors.forename: A G
authors.initials: AG
authors.lastname: Meining
authors.forename: E
authors.initials: E
authors.lastname: Bayerdörffer
authors.forename: M
authors.initials: M
authors.lastname: Stolte
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005756:Gastritis / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology*; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000453:epidemiology / Q000235:genetics*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*