Depolarizing neuromuscular junctional blocking action of Parthenium hysterophorus leaf extracts in rat.
Electromyographic (EMG) and electrodiagnostic studies were made on sciatic nerve-anterior tibialis muscle in vivo in rats administered with a sublethal dose of Parthenium hysterophorus dry leaf powder 100 mg/100 g body weight of rat. Nerve-evoked and muscle-evoked compound muscle action potentials were recorded at different frequencies of stimulations and at different time intervals. The EMG studies revealed depolarizing neuromuscular junctional (NMJ) blocking effects of the leaf extract. The decrement-increment (D-I) phenomena and the EMG pattern in general showed a resemblance to an established anticholinesterase agent like neostigmine. The studies confirm that the leaf extract contains a proven and promising new depolarizing NMJ blocker.
Vijayalakshmi
P
P
Division of Environmental Biology, Department of Zoology, S. V. University, Tirupati - 517 502. A.P. India.
Vijayalakshmi
K M
KM
Nanda Kumar
N V
NV
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D004576:Electromyography; D066298:In Vitro Techniques; D018482:Muscle, Skeletal / Q000187:drug effects / Q000294:innervation; D009467:Neuromuscular Depolarizing Agents / Q000302:isolation & purification / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010947:Plants, Toxic / Q000737:chemistry*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects
D009467:Neuromuscular Depolarizing Agents; D010936:Plant Extracts