Blocking Gibbs sampling for linkage analysis in large pedigrees with many loops.
We apply the method of "blocking Gibbs" sampling to a problem of great importance and complexity-linkage analysis. Blocking Gibbs sampling combines exact local computations with Gibbs sampling, in a way that complements the strengths of both. The method is able to handle problems with very high complexity, such as linkage analysis in large pedigrees with many loops, a task that no other known method is able to handle. New developments of the method are outlined, and it is applied to a highly complex linkage problem in a human pedigree.
Jensen
C S
CS
Department of Mathematics and Computer Science, Institute for Electronic Systems, Aalborg University, Aalborg, Denmark. claus@cs. auc.dk
Kong
A
A
D000465:Algorithms; D000483:Alleles; D001499:Bayes Theorem; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008133:Long QT Syndrome / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic