[Malignant hyperthermia and neuroleptic malignant syndrome: report of 4 clinical cases].
Very numerous publication in the literature suggest the probable relationship between three clinical entities: peranesthesic malignant hyperthermia (PMH), exercitional malignant hyperthermia (EMH) and neuroleptic malignant syndrome (NMS). We briefly describe the clinical history and define, as subjects of research, the personal and familial histories of neuromuscular disease of 4 of our patients having presented with neuroleptic malignant syndrome, as recommended by the European group on malignant hyperthermia, the reference contracture test on neuromuscular fibers and anatomic and cytopathological investigations of neuromuscular fibers. We compare the results for our 4 patients having presented with neuroleptic malignant syndrome and their courses. We confirm the necessity of pursuing both case history and laboratory research in order to elucidate the debate on the hypothesis of a common etiopathogenesis for the 3 syndrome entities.
Samuelian
J C
JC
Psychiatre des Hôpitaux, Service de Psychiatrie, CHU la Timone, Marseille.
Chabannes
J M
JM
Vedy
P
P
Kozak-Reiss
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001706:Biopsy; D002389:Catatonia / Q000188:drug therapy; D002908:Chronic Disease; D003286:Contracture / Q000150:complications / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis*
D014150:Antipsychotic Agents
Hyperthermie maligne et syndrome malin des neuroleptiques A propos de quatre observations cliniques.