title: [Therapeutic results in patients with malignant granulosa cell tumors at the Gynecologic Clinic of the city of Pécs].
abstract: In the Department of Obstetrics and Gynecology, University Medical School of Pecs, Hungary 92 patients had been treated with malignant human granulosa cell tumor between 1960-1997. The youngest patient was 14 years old, the oldest 77. The average age was 52.5 years. The disease occurred mostly in 50-60 year old women, and most of them have never given birth before. In 64 cases (69%) metrorrhagia and low abdominal pain were the leading symptoms. 61% of cases the disease was diagnosed in the 1st stage, 14% in the 2nd, 18.5% in the 3rd, and 6.5% in the 4th stage. According to the endometrial histologic examination, data of increased estradiol production was found in 75% of the patients. Along with granulosa cell tumor breast cancer occurred in 2 cases, endometrial carcinoma was diagnosed in 4 cases, and atypical endometrial hyperplasia in 6 cases. After the operation 67 patients received radiation therapy, 5 chemotherapy and 16 combined radiation and chemotherapy. The 2 year survival rate of the 87 patients treated between 1960-1994 was 87.4% the 5 year survival rate was 64.4%. In the stage 1 had 92.4% of patients lived 2 years tumor free, 83.0% lived 5 years without recurrence of tumor. The cleaned 5 year survival rate was found in 88%. With the survey of the youngest patient's case the authors pointed out the highly malignant, rapid course, and the changing of the sera hormones during the therapy.
authors.affiliation: Pécsi Orvostudományi Egyetem, Szülészeti és Nögyógyászati Klinika.
authors.forename: K
authors.initials: K
authors.lastname: Krommer
authors.forename: P
authors.initials: P
authors.lastname: Göcze
authors.forename: Z
authors.initials: Z
authors.lastname: Garamvölgyi
authors.forename: K
authors.initials: K
authors.lastname: Kovács
authors.forename: I
authors.initials: I
authors.lastname: Szabó
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006106:Granulosa Cell Tumor / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007044:Hysterectomy; D008875:Middle Aged; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*
vernacular_title: Rosszindulatú granulosasejt-daganatos betegek és gyógyulási eredményeik a Pécsi Nöi Klinikán.