title: Contents of fragrance allergens in children's cosmetics and cosmetic-toys.
abstract: Fragrances are one of the major causes of allergic contact dermatitis from use of cosmetics. The aim of the current study was to assess the possible exposure of infants and children to fragrance allergens from cosmetic products and "toy-cosmetics". 25 children's cosmetics or toy-cosmetic products were analysed by gas chromatography - mass spectrometry. Target substances were the fragrance allergens from the fragrance mix and 14 other fragrance substances, most of which have been described as contact allergens. The fragrance mix ingredients were either not present in children's shampoos/shower gels and cream/lotions, or they were present in fairly low concentrations. In hydro-alcoholic products, such as eau de parfum, eau de toilette, several ingredients of the fragrance mix were found: geraniol was present in 7/7 products, hydroxycitronellal in 6/7 and isoeugenol in 2/7 products. Isoeugenol was present in a maximum concentration of 0.07%. In one cosmetic-toy, cinnamic alcohol was present at 3.7% which exceeds the current industry guideline for safe products by a factor of 5. In all types of products other fragrance allergens were frequently found. In conclusion, children are already exposed at an early age to well-known allergens, sometimes at concentrations which are considered to be unsafe. As contact allergy usually persists for life, manufacturers of children's cosmetics should be aware of their special responsibility and apply the highest possible safety standards.
authors.affiliation: Department of Environmental Chemistry, National Environmental Research Institute, Roskilde, Denmark.
authors.forename: S C
authors.initials: SC
authors.lastname: Rastogi
authors.forename: J D
authors.initials: JD
authors.lastname: Johansen
authors.forename: T
authors.initials: T
authors.lastname: Menné
authors.forename: P
authors.initials: P
authors.lastname: Frosch
authors.forename: M
authors.initials: M
authors.lastname: Bruze
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.forename: J P
authors.initials: JP
authors.lastname: Lepoittevin
authors.forename: S
authors.initials: S
authors.lastname: Wakelin
authors.forename: I R
authors.initials: IR
authors.lastname: White
mesh_terms: D000485:Allergens / Q000032:analysis*; D002648:Child; D002849:Chromatography, Gas; D003358:Cosmetics / Q000009:adverse effects* / Q000737:chemistry*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D010988:Play and Playthings
chemical_list: D000485:Allergens; D003358:Cosmetics