title: Dose response to soluble fiber in barley in lowering blood lipids in hamster.
abstract: Diets containing 0, 25, 50, or 75% finely ground barley (high in soluble fiber and soluble beta-glucans) were fed to groups of hamsters. After four weeks, serum total cholesterol (CH) levels in these animals were most elevated in the group fed the barley-free (0% barley) diet. Compared to animals eating this diet, the 25% barley diet lowered CH by 16.4%. However, the 50% barley diet lowered CH further by only 4.1% while the 75% barley diet caused virtually no further lowering of CH. Thus, the CH-lowering response to barley cannot be viewed as a dose dependent response. The lowering pattern for serum triglycerides, however, suggested a dose dependent response. Serum total-CH: high-density-lipoprotein (HDL)-CH or low-density-lipoprotein (LDL)-CH:HDL-CH ratios were not significantly affected by barley level in the diets.
authors.affiliation: Nutrition Research Program, American Institute of Baking, Manhattan, KS 66505, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Ranhotra
authors.forename: J A
authors.initials: JA
authors.lastname: Gelroth
authors.forename: S D
authors.initials: SD
authors.lastname: Leinen
authors.forename: R S
authors.initials: RS
authors.lastname: Bhatty
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006224:Cricetinae; D004043:Dietary Fiber / Q000008:administration & dosage*; D001467:Hordeum; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D012995:Solubility; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004043:Dietary Fiber; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol