Wnt signaling and dorso-ventral axis specification in vertebrates.
The dorso-ventral axis is specified in vertebrates through the formation of a dorsal signaling center known as the Spemann organizer. This process depends on signal transduction by beta-catenin that can be regulated by secreted Wnt proteins. Recent discoveries of new players in this signaling pathway have narrowed down the search for the initial cues for axis specification in vertebrate embryos.
Sokol
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Department of Microbiology and Molecular Genetics, Harvard Medical School, Molecular Medicine Unit, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Massachusetts 02215, USA. ssokol@caregroup.harvard.edu
D000818:Animals; D005314:Embryonic and Fetal Development; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins