Radioimmunoscintigraphy in patients with ovarian cancer.
The targeting potential of three different monoclonal antibodies (MAbs) was assessed in patients with ovarian cancer. HMFG1, OC-125 and H17E2 labelled with 111In or 123I were evaluated prospectively for their ability to localize ovarian tumour. Forty two patients with ovarian cancer, aged 40-78 years (median = 58 years) were studied using OC-125 (n = 9), HMFG1 (n = 11) and H17E2 (n = 22). Imaging data were compared with the CT and the surgical findings. Presence of tumour was confirmed in 35/42 (83%) patients (8/9 OC-125, 10/11 HMFG1 and 17/22 H17E2) and correlated well with the conventional radiology diagnostic methods. One patient with a negative H17E2 scan and a large abdominal mass detected at laparotomy revealed a PLAP-negative tumour on immunohistochemistry. Scintigraphy revealed the presence of active disease, confirmed by laparotomy/laparoscopy in 6/8 patients considered to be in clinical remission. The sensitivity of the method was high enough and the diagnostic contribution of this approach should be further evaluated.
Kalofonos
H P
HP
Department of Medicine/Oncology, University Hospital of Patras, Rion, Greece. kalofon@med.upatras.gr
Giannakenas
C
C
Kosmas
C
C
Apostolopoulos
D
D
Onienadum
A
A
Petsas
T
T
Dimopoulos
D
D
Epenetos
A A
AA
Vassilakos
P J
PJ
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D016719:Radioimmunodetection / Q000379:methods*; D012680:Sensitivity and Specificity
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes