title: [The future of antifungal agents. Non azole antifungal agents].
abstract: We investigated the efficacy of non-azole antifungal agents. Long circulating immunoliposomal amphotericin B was potent in murine invasive pulmonary aspergillosis. The concentration of AMPH-B was still high in the lung after 6 hours of 34A-PEG-liposomal AMPH-B. Lipid nanosphere amphotericin B (NS-718) showed efficacy against pulmonary aspergillosis in rats and pulmonary cryptococcosis in mice. The renal toxicity of NS-718 was estimated to be lower than that of AMPH-B from the results of the toxicity study in the rat infusion model. FK 463, a novel (1,3)-beta-D-glucan synthase inhibitor, showed efficacy against azole-resistant Candida albicans in murine experimental disseminated candidiasis. FK463 could be a promising drug and the therapy of choice for azole resistant C. albicans infection.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto Nagasaki 852-8501.
authors.forename: S
authors.initials: S
authors.lastname: Maesaki
authors.forename: M A
authors.initials: MA
authors.lastname: Hossain
authors.forename: E
authors.initials: E
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Hashiguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Higashiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshitsugu
authors.forename: K
authors.initials: K
authors.lastname: Tomono
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D054714:Echinocandins; D005437:Flucytosine; D005658:Fungi / Q000201:enzymology; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology; D008081:Liposomes; D008565:Membrane Proteins; D000077551:Micafungin; D051379:Mice; D009181:Mycoses / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D029702:Schizosaccharomyces pombe Proteins
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D008081:Liposomes; D008565:Membrane Proteins; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins; D000666:Amphotericin B; D005437:Flucytosine; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase; D000077551:Micafungin