title: Multiple chromosomal abnormalities in fulminant anaplastic myeloma.
abstract: We describe a 58-year-old woman with anaplastic multiple myeloma and multiple chromosomal abnormalities. Her karyotype showed extreme hyperploidy with 77 chromosomes. Some of the aberrations were typical of multiple myeloma (+3, +5, +15, +19, +21, t(11;14)(q13;q32)), others were characteristic of the aggressive anaplastic myeloma (+8), t(11;14)(q13;q32), while three chromosomal abnormalities (t(11;20)(p11;q13); t(4;7)(q31;q11); and t(14;20)(q24;q13)) have not been, to the best of our knowledge, described previously in the literature. The fulminant course of the disease confirms the poor prognosis of multiple karyotypic abnormalities in myeloma.
authors.affiliation: Hematology Institute, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Maslovsky
authors.forename: G
authors.initials: G
authors.lastname: Lugassy
authors.forename: R
authors.initials: R
authors.lastname: Blumental
authors.forename: A
authors.initials: A
authors.lastname: Ducach
authors.forename: O
authors.initials: O
authors.lastname: Yehuda
authors.forename: D
authors.initials: D
authors.lastname: Abeliovich
mesh_terms: D002869:Chromosome Aberrations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology