title: [Langerhans cell histiocytosis and myelomonocytic leukemia: a non-fortuitous association].
abstract: BACKGROUND
  Langerhans cell histiocytosis is an uncommon clonal disorder. Its reactional or genetic nature is debated.
  
  
  METHODS
  Three patients aged 71, 75 and 73 years with Langerhans cell histiocytosis also developed myelomoncytic leukemia (AML4, AML5, and chronic myelomonocytic leukemia). In two cases, there was no prior treatment which could potentially induce leukemia. In the third case, AML4 occurred shortly (10 months) after initiation of a vinblastin treatment.
  
  
  CONCLUSIONS
  This pathogenic association suggests a common origin for these two conditions, corresponding to an anomalous pluripotent stem cell line. These cases provide further evidence favoring the hypothesis of a genetic origin rather than a reactional origin for Langerhans cell histiocytosis.
authors.affiliation: Service de Dermatologie, Hôpital Bichat-Claude Bernard, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Baikian
authors.forename: V
authors.initials: V
authors.lastname: Descamps
authors.forename: M
authors.initials: M
authors.lastname: Grossin
authors.forename: E
authors.initials: E
authors.lastname: Marinho
authors.forename: C
authors.initials: C
authors.lastname: Picard
authors.forename: G
authors.initials: G
authors.lastname: Aitken
authors.forename: M
authors.initials: M
authors.lastname: Sigal
authors.forename: B
authors.initials: B
authors.lastname: Crickx
authors.forename: S
authors.initials: S
authors.lastname: Belaich
mesh_terms: D000368:Aged; D001706:Biopsy; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007402:Intertrigo / Q000473:pathology; D015479:Leukemia, Myelomonocytic, Acute / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D012307:Risk Factors; D012867:Skin / Q000473:pathology
vernacular_title: Histiocytose langerhansienne et leucémie de la lignée myélomonocytaire: une association non fortuite.