Lipid reactivity among men with a parental history of myocardial infarction.
In the current study, we examined lipid and cardiovascular responses to an acute stressor among men with and without a parental history of myocardial infarction. 37 men were selected from a large group who completed medical history questionnaires and interviews. Twenty-two men who denied parental history of heart disease (negative parental history) were compared with 15 men with one or both parents who had suffered a myocardial infarction (positive parental history). Total cholesterol, high- and low-density lipoprotein cholesterol, triglycerides, heart rate, and blood pressure were measured at rest and during a videotaped speech stressor. Positive parental history men had significantly higher low-density lipoprotein cholesterol levels and blood pressure at baseline, significantly lower high-density lipoprotein cholesterol levels at baseline, and significantly larger total cholesterol and low-density lipoprotein cholesterol reactivity, relative to negative parental history men. Because parental history is a risk factor for subsequent cardiovascular morbidity and mortality, these data suggest that lipid reactivity to stress may be biologically important.
Stoney
C M
CM
Department of Psychology, Ohio State University, Columbus 43210-1222, USA. stoney.1@osu.edu
Hughes
J W
JW
D000328:Adult; D000704:Analysis of Variance; D002320:Cardiovascular Physiological Phenomena; D005192:Family Health; D020022:Genetic Predisposition to Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology
D008055:Lipids