title: Effects of 17beta-estradiol on the baroreflex control of sympathetic activity in conscious ovariectomized rats.
abstract: The effects of chronic treatment with 17beta-estradiol on baroreflex control of sympathetic activity were examined in conscious unrestrained ovariectomized rats. Baroreflex function was evaluated by logistic sigmoidal analysis of the relationships between changes in mean arterial pressure (MABP) and changes in heart rate (HR) and splanchnic nerve activity (SNA) when MABP was rapidly increased to 150 mmHg by intravenous phenylephrine after its reduction to 50 mmHg by intravenous nitroprusside. These baroreflex function curves were similar in vehicle- and estradiol-treated rats. However, after a 30-min infusion of vasopressin in vehicle-treated rats, the curve for HR was shifted downward, and the upper plateau and maximum gain for the SNA curve were reduced. These effects were abolished by estradiol. A 30-min phenylephrine infusion had no effect on the baroreflex curves. Thus estrogen can modulate the action of vasopressin on baroreflex control of sympathetic outflow and thereby participate in cardiovascular regulation.
authors.affiliation: Department of Physiology, University of Tennessee, Memphis, Memphis, Tennessee 38163, USA.
authors.forename: X R
authors.initials: XR
authors.lastname: He
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: J T
authors.initials: JT
authors.lastname: Crofton
authors.forename: L
authors.initials: L
authors.lastname: Share
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001127:Arginine Vasopressin / Q000494:pharmacology; D017704:Baroreflex / Q000187:drug effects* / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D009599:Nitroprusside / Q000494:pharmacology; D010052:Ovariectomy; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013153:Splanchnic Nerves / Q000187:drug effects / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D001127:Arginine Vasopressin; D009599:Nitroprusside; D010656:Phenylephrine; D004958:Estradiol