New hexahydrocarbazoles and spiro indoles, and their affinity for D2 dopamine and 5-HT2A serotonin receptors.
In a search for novel atypical antipsychotics, the synthesis of new hexahydrocarbazoles and spiro indoles N-substituted with a 3-(dimethylamino)propyl chain is described, together with the results of an in vitro evaluation of their affinities for D2 and 5-HT2A receptors.
Fernández
F
F
Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Santiago de Compostela, Spain.
García-Mera
X
X
Rodríguez
G
G
Urrutia
A
A
D000818:Animals; D014150:Antipsychotic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007650:Ketanserin / Q000493:pharmacokinetics; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics; D013134:Spiperone / Q000378:metabolism
D014150:Antipsychotic Agents; D002227:Carbazoles; D018492:Dopamine Antagonists; D007211:Indoles; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013134:Spiperone; D007650:Ketanserin