title: Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues.
abstract: Leptin concentrations are elevated in the majority of obese individuals raising the possibility that leptin resistance contributes to their obesity. Peripheral leptin administration for 48 h caused a several-fold increase in mRNA encoding the suppressors of cytokine signaling SOCS-3 and CIS in hypothalamus and peripheral tissues. Paradoxically, CIS and SOCS-3 mRNAs are also elevated in the leptin-deficient ob/ob mouse. Forced expression of CIS in insulinoma cells prevented transactivation mediated by leptin. Thus tissues continuously exposed to leptin and/or other factors associated with obesity accumulate excessive amounts of SOCS-3 and CIS which could provide a potential mechanism for leptin resistance.
authors.affiliation: Clore Laboratory, University of Buckingham, UK. valur.emilsson@buckingham.ac.uk
authors.forename: V
authors.initials: V
authors.lastname: Emilsson
authors.forename: J R
authors.initials: JR
authors.lastname: Arch
authors.forename: R P
authors.initials: RP
authors.lastname: de Groot
authors.forename: C A
authors.initials: CA
authors.lastname: Lister
authors.forename: M A
authors.initials: MA
authors.lastname: Cawthorne
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D020738:Leptin; D051379:Mice; D011506:Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D012097:Repressor Proteins; D015398:Signal Transduction / Q000187:drug effects*; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D014157:Transcription Factors
chemical_list: D017931:DNA Primers; D020738:Leptin; D011506:Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; D012097:Repressor Proteins; C491411:Socs3 protein, mouse; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D014157:Transcription Factors