Inhibitors of inositol monophosphatase.
Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol monophosphates to myo-inositol, which is required in the phosphatidyl inositol cell signalling pathway. Here the enzyme structure, mechanism and inhibition of IMPase are reviewed. Lithium, an effective therapy for manic depression, is an uncompetitive inhibitor. In the search for alternative inhibitors to lithium, substrate-based inhibitors, bisphosphonates, terpenoid and tropolone analogues are described.
Fauroux
C M
CM
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
Freeman
S
S
D007294:Inositol / Q000031:analogs & derivatives; D008094:Lithium / Q000494:pharmacology; D063065:Organophosphonates / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D011355:Prodrugs / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D015398:Signal Transduction; D013729:Terpenes / Q000494:pharmacology; D014334:Tropolone / Q000031:analogs & derivatives
D063065:Organophosphonates; D010716:Phosphatidylinositols; D011355:Prodrugs; D011619:Psychotropic Drugs; D013729:Terpenes; D007294:Inositol; D014334:Tropolone; D008094:Lithium; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase