title: Synthesis of cis-disubstituted cyclobutenyl nucleoside analogues.
abstract: cis-Disubstituted cyclobutene nucleosides analogues were prepared by a linear synthesis starting from cis-cyclobutene dicarboxylic anhydride. This strategy involved mild reaction conditions with intent to restrict the thermal electrocyclic ring opening into (Z,E)-dienes.
authors.affiliation: Laboratoire de Synthèse Organique, ESA 6011, Faculté des Sciences, Université du Maine, Le Mans, France.
authors.forename: M E
authors.initials: ME
authors.lastname: Gourdel-Martin
authors.forename: F
authors.initials: F
authors.lastname: Huet
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000475:Alkenes; D009705:Nucleosides