title: Sensitivity and specificity of three clinical criteria for dementia with Lewy bodies in an autopsy-verified sample.
abstract: OBJECTIVE
  To evaluate the sensitivity and specificity of the clinical features of three published diagnostic criteria for diffuse Lewy body disease (DLBD) using autopsy-confirmed Alzheimer's (AD), DLBD and AD+DLBD (mixed) dementia cases.
  
  
  METHODS
  Retrospective chart review of an autopsy series of 56 patients selected from the State of Florida Brain Bank on the basis of a pathological diagnosis of either pure AD, DLBD (pure and common forms) or AD+DLBD (mixed) dementia. Clinical features were assessed by three raters blind to the pathological diagnosis.
  
  
  RESULTS
  The existing criteria for a clinical diagnosis of DLBD were highly specific (90-100%) but not very sensitive (49-63%) in the differential diagnosis of DLBD versus AD; sensitivity did improve (61-74%) when mixed AD+DLBD cases were eliminated. Clinical features that occur more frequently in DLBD than in AD were unspecified hallucinations, unspecified EPS, fluctuating course and rapid progression. Post-hoc analysis also indicated that hallucinations and EPS were more common early in the disease course of DLBD than in AD. Empirically derived criteria, formulated using the most prevalent clinical features, demonstrated sensitivity values of 57-96% for pure forms and 43-91% for mixed forms.
  
  
  CONCLUSIONS
  This study demonstrated that additional improvements in the established criteria for DLBD are needed. Our empirically derived criteria enhanced the distinction of DLBD from AD while allowing the clinician the choice of maximizing sensitivity with acceptable specificity, and vice versa.
authors.affiliation: Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL 33141, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Luis
authors.forename: W W
authors.initials: WW
authors.lastname: Barker
authors.forename: K
authors.initials: K
authors.lastname: Gajaraj
authors.forename: D
authors.initials: D
authors.lastname: Harwood
authors.forename: R
authors.initials: R
authors.lastname: Petersen
authors.forename: A
authors.initials: A
authors.lastname: Kashuba
authors.forename: C
authors.initials: C
authors.lastname: Waters
authors.forename: P
authors.initials: P
authors.lastname: Jimison
authors.forename: G
authors.initials: G
authors.lastname: Pearl
authors.forename: C
authors.initials: C
authors.lastname: Petito
authors.forename: D
authors.initials: D
authors.lastname: Dickson
authors.forename: R
authors.initials: R
authors.lastname: Duara
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D001344:Autopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006212:Hallucinations; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity