[Torsades de pointes during treatment of leishmaniasis with meglumine antimoniate].
Antimonial agents are the main drug to treat all forms of leishmaniasis. Meglumine antimoniate is the drug available in Spain and it is usually well tolerated. Nevertheless, this drug frequently alters ventricular repolarization, but few cases of sudden death, presumably related to ventricular arrhythmias, have been reported. We present a case of torsade de pointes during treatment with meglumine antimoniate coexisting with a severe hypokalemia probably due to an acute transitory tubulopathy.
Castelló Viguer
M T
MT
Servicio de Cardiología, Hospital General Universitario, Valencia.
Echánove Errazti
I
I
Ridocci Soriano
F
F
Esteban Esteban
E
E
Atienza Fernández
F
F
Cuesta Estellés
G
G
D000368:Aged; D000965:Antimony / Q000009:adverse effects* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007896:Leishmaniasis / Q000150:complications* / Q000188:drug therapy; D008536:Meglumine / Q000009:adverse effects* / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000150:complications / Q000503:physiopathology
D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony
Torsade de pointes durante el tratamiento de la leishmaniasis con antimoniato de meglumina.