title: Neurolymphomatosis in Waldenström's macroglobulinaemia.
abstract: We report four patients with Waldenström's macroglobulinaemia with an unusual neurologic complication, neurolymphomatosis, characterized by meningeal and root nerve infiltration by lymphoplasmacytic cells. Patients presented with rapidly progressive leg proximal weakness. Examination of cerebrospinal fluid disclosed lymphoplasmacytic cells. Magnetic resonance imaging of the lumbar spine was suggestive of a tissular infiltration of leptomeninges and nerve roots. Chemotherapy and irradiation of involved tissues led to a remarkable and sustained neurological improvement.
authors.affiliation: Service d'Immunologie Clinique, Hôpital Saint-Louis, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Abad
authors.forename: A M
authors.initials: AM
authors.lastname: Zagdanski
authors.forename: S
authors.initials: S
authors.lastname: Brechignac
authors.forename: B
authors.initials: B
authors.lastname: Thioliere
authors.forename: J C
authors.initials: JC
authors.lastname: Brouet
authors.forename: X
authors.initials: X
authors.lastname: Mariette
mesh_terms: D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis