title: Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium.
abstract: Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0236, USA.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: P R
authors.initials: PR
authors.lastname: Jensen
authors.forename: W
authors.initials: W
authors.lastname: Fenical
mesh_terms: D000192:Actinomycetales / Q000737:chemistry / Q000378:metabolism*; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D004427:Ear Diseases / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005285:Fermentation; D007274:Injections, Intraperitoneal; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014871:Water Microbiology
chemical_list: D000893:Anti-Inflammatory Agents; D018942:Macrolides; C121297:lobophorin A; C121298:lobophorin B; D013755:Tetradecanoylphorbol Acetate