[Acute transverse cervical myelitis following hepatitis B vaccination. Evolution of anti-HBs antibodies].
BACKGROUND
The cause and effect relationship between anti-HBV immunization using recombinant vaccine and the development of a neurological event, including flare-ups of multiple sclerosis, is a widely debated issue.


METHODS
A previously asymptomatic 16-year-old girl was a hyper-responder to anti-HBV vaccine. Subsequent to a booster shot of anti-HBV recombinant vaccine, she developed regressive acute cervical transverse myelitis with intrathecal oligochonal IgG secretion and a hypersignal on the MRI T2 sequences of the cord.


CONCLUSIONS
The distinction between a first episode of multiple sclerosis or post-vaccinal acute myelitis in this case will depend upon subsequent course, but this observation points out the very high level of persistent post-vaccinal immunization which can be acquired by a hyper-responder.
Renard
J L
JL
Clinique de neurologie, HIA Val-de-Grâce, Paris.
Guillamo
J S
JS
Ramirez
J M
JM
Taillia
H
H
Felten
D
D
Buisson
Y
Y
D000293:Adolescent; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D005260:Female; D006510:Hepatitis B Antibodies / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis; D009187:Myelitis / Q000175:diagnosis / Q000209:etiology*; D013118:Spinal Cord Diseases / Q000175:diagnosis; D014614:Vaccines, Synthetic
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic
Myélite transverse aiguë cervicale après vaccination contre le virus de l'hépatite B. Evolution sérologique des anticorps anti-HBs.