Changes in levels of phosphorus metabolites in temporal lobes of drug-naive schizophrenic patients.
OBJECTIVE
The authors examined phospholipids and high-energy phosphorus metabolism in the temporal lobes of drug-naive schizophrenic patients.


METHODS
In vivo 31P magnetic resonance spectroscopy was performed on 17 first-episode, drug-naive schizophrenic patients and 17 age- and gender-matched healthy subjects.


RESULTS
Patients showed higher levels of phosphodiesters and lower levels of phosphomonoesters than the comparison group. Phosphocreatine levels were increased in the left temporal lobes of patients.


CONCLUSIONS
The results suggest disturbed membrane phospholipid metabolism in both temporal lobes and decreased energy demands in the left temporal lobes of drug-naive schizophrenic patients.
Fukuzako
H
H
Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, Japan. fukuzako@med4.kufm.kagoshima-u.ac.jp
Fukuzako
T
T
Hashiguchi
T
T
Kodama
S
S
Takigawa
M
M
Fujimoto
T
T
D000328:Adult; D000704:Analysis of Variance; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D004952:Esters; D004983:Ethanolamines / Q000378:metabolism; D005260:Female; D007839:Functional Laterality; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*; D010759:Phosphorus Isotopes; D010767:Phosphorylcholine / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D004952:Esters; D004983:Ethanolamines; D010743:Phospholipids; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D010767:Phosphorylcholine; D010758:Phosphorus; C005448:phosphorylethanolamine