[The effect of the lysosomal function of circulating neutrophils on hemostasis and on the morphological changes in the internal organs in the disseminated intravascular coagulation syndrome].
Development of experimental the syndrome of disseminated intravascular coagulation, DIC syndrome, in organism laboratory animals from affect preparation "EFA-2" by accompanied increase quantity of neutrophiles circulations, modifications of the lysosomal apparatus of neutrophiles the activity of the serum acid phosphatase increased, characteristic damage on hemostasis system and typical alteration in some organs. As a result limitation of number of neutrophiles was achieved of suppression, of granulocytopoiesis by means "Myelosan" pharmacy, did not increase activity in blood serum solution lysosomal enzyme of neutrophils and not development in organism DIC syndrome. Made conclusion, the neutrophils have influence of promotion generalization DIC syndrome.
Koval'
S B
SB
A. A. Bogomolets Institute of Physiology, NAS Ukraine, Kiev.
Boiarchuk
O D
OD
Lunina
N V
NV
D000135:Acid Phosphatase / Q000097:blood / Q000187:drug effects; D000818:Animals; D015415:Biomarkers / Q000097:blood; D002066:Busulfan / Q000494:pharmacology; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D011817:Rabbits
D015415:Biomarkers; D000135:Acid Phosphatase; D002066:Busulfan
Vplyv stanu lizosomal'noho aparatu tsyrkuliuiuchykh neĭtrofiliv na hemostaz ta morfolohichni zminy deiakykh vnutrishnikh orhaniv pry syndromi dyseminovanoho vnutrishn'osudynnoho zhortannia krovi.