[Antibodies depress the meiotic oocyte maturation of mice in vitro].
Experiments on mouse of the CBA line have shown that polyclonal antiovarian and specific to oolemma monoclonal antibodies depress meiotic maturation of oocytes in vitro and potentially can be the reason for the female infertility. Changes in electrogenic properties and Ca2+ channels of oolemma are likely to be in the base of the mechanisms of depressing action of antibodies on meiotic maturation.
Hotsuliak
Ia M
IaM
A. A. Bogomoletz Institute of Physiology, NAS, Ukraine.
Ianchiĭ
R I
RI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002478:Cells, Cultured; D003864:Depression, Chemical; D005260:Female; D008540:Meiosis / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D009865:Oocytes / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D010053:Ovary / Q000276:immunology*; D015044:Zona Pellucida / Q000276:immunology*
D000906:Antibodies; D000911:Antibodies, Monoclonal
Antytila prihnichuiut' meĭotychne dozrivannia ootsytiv mysheĭ in vitro.