title: Postexercise motor evoked potentials in depressed patients, recovered depressed patients, and controls.
abstract: We hypothesized that impaired postexercise motor evoked potential (MEP) facilitation in depressed patients would reverse with recovery from depression. Transcranial magnetic stimulation and exercise of the thenar muscles were used to examine the 10 controls, 10 medicated depressed patients, and 10 medicated recovered patients. Depressed patients showed reduced mean postexercise facilitation compared to both controls (p = 0.005) and recovered patients (p = 0.012). Controls and recovered patients had similar mean postexercise MEPs (p = 0.45). This is consistent with other evidence of reversibility of abnormal findings following recovery from depression.
authors.affiliation: MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Scotland, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Shajahan
authors.forename: M F
authors.initials: MF
authors.lastname: Glabus
authors.forename: J A
authors.initials: JA
authors.lastname: Jenkins
authors.forename: K P
authors.initials: KP
authors.lastname: Ebmeier
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000503:physiopathology*; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013997:Time Factors