Seminoma associated with bilateral cryptorchidism in Down's syndrome: a case report.
BACKGROUND
A case of testicular typical seminoma associated with bilateral undescended testes in Down's syndrome is reported. A 42-year-old institutionalized male patient developed left testicular seminoma with retroperitoneal metastasis.


RESULTS
Neither adjuvant chemotherapy nor radiotherapy were performed due to his severe mental retardation. He died as a result of the cancer 2 years after a left radical orchiectomy and an autopsy was carried out.


CONCLUSIONS
Recently an increase in the incidence of the association of testicular tumors and Down's syndrome has been repeatedly documented. Thirty-six cases of testicular tumors associated with Down's syndrome have been reported and of these 17.1% had cryptorchidism. This is a much lower percentage considering the high risk of cryptorchidism in males with Down's syndrome. The relationship between testicular germ cell tumors associated with cryptorchidism and Down's syndrome is discussed.
Miki
M
M
Department of Urology, Asama General Hospital, Saku, Nagano, Japan. bell@avis.ne.jp
Ohtake
N
N
Hasumi
M
M
Ohi
M
M
Moriyama
S
S
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood; D003456:Cryptorchidism / Q000150:complications* / Q000601:surgery; D004314:Down Syndrome / Q000150:complications*; D017809:Fatal Outcome; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009919:Orchiectomy; D012189:Retrospective Studies; D018239:Seminoma / Q000097:blood / Q000150:complications* / Q000601:surgery; D013736:Testicular Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D013739:Testosterone / Q000097:blood
D014408:Biomarkers, Tumor; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone