Synthetic studies on 2'-substituted-4'-thiocytidine derivatives as antineoplastic agents.
As potential antineoplastic agents, we have synthesized 4'-thioFAC and 4'-thiocytarazid by developing an alternative synthetic method. 4'-ThioFAC showed potent antineoplastic activities in vivo as well as in vitro.
Yoshimura
Y
Y
Biochemicals Division, Yamasa Corporation, Chiba, Japan. chem2yms@choshinet.or.jp
Endo
M
M
Kitano
K
K
Yamada
K
K
Sakata
S
S
Miura
S
S
Machida
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003562:Cytidine / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D013872:Thionucleosides / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013872:Thionucleosides; D003562:Cytidine