title: Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients.
abstract: Interstitial ciprofloxacin concentrations were measured by microdialysis in inflamed foot lesions of non-insulin-dependent diabetes mellitus patients following intravenous administration of 0. 2 g of ciprofloxacin. Interstitial ciprofloxacin concentrations were significantly lower than corresponding serum concentrations. There was no significant difference in the penetration of ciprofloxacin into inflamed and unaffected tissue (area under the concentration-time curve(infection)/area under the concentration-time curve(unaffected tissue) = 0.99 +/- 0.15 [mean +/- standard error], n = 6). Thus, inflammation appears to have little or no effect on the penetration of ciprofloxacin into tissue.
authors.affiliation: Departments of Clinical Pharmacology, University of Vienna Medical School, Vienna, Austria. markus.mueller@univie.ac.at
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Brunner
authors.forename: U
authors.initials: U
authors.lastname: Hollenstein
authors.forename: C
authors.initials: C
authors.lastname: Joukhadar
authors.forename: R
authors.initials: R
authors.lastname: Schmid
authors.forename: E
authors.initials: E
authors.lastname: Minar
authors.forename: H
authors.initials: H
authors.lastname: Ehringer
authors.forename: H G
authors.initials: HG
authors.lastname: Eichler
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000378:metabolism*; D017719:Diabetic Foot / Q000097:blood / Q000378:metabolism* / Q000382:microbiology; D005110:Extracellular Space / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D017551:Microdialysis
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin