Molecular genetic characterisation of frontotemporal dementia on chromosome 3.
We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.
Ashworth
A
A
Department of Neurogenetics, Imperial College School of Medicine at St Mary's, London, UK.
Lloyd
S
S
Brown
J
J
Gydesen
S
S
Sorensen
S A
SA
Brun
A
A
Englund
E
E
Humphreys
C
C
Housman
D
D
Badura
M
M
Stanton
V
V
Taylor
K
K
Cameron
J
J
Munroe
D
D
Johansson
J
J
Rossor
M
M
Fisher
E M
EM
Collinge
J
J
D000328:Adult; D002648:Child; D002893:Chromosomes, Human, Pair 3 / Q000502:physiology*; D003360:Cosmids / Q000235:genetics; D016172:DNA Fingerprinting; D003704:Dementia / Q000235:genetics* / Q000378:metabolism; D003718:Denmark; D018450:Disease Progression; D005625:Frontal Lobe / Q000378:metabolism*; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D010375:Pedigree; D013702:Temporal Lobe / Q000378:metabolism*; D018911:Trinucleotide Repeats