title: Idiopathic pinealitis. Case report.
abstract: This 63-year-old man presented with complaints of "having a feeling of falling backward" over a 3-month period. Results of his general physical examination, laboratory studies, and neurological examination were unremarkable. A magnetic resonance image revealed a 1.8 x 1.4 x 1.2-cm enhancing mass in the posterior third ventricle just above the corpora quadrigemina. The pineal gland was found to be diffusely enlarged at operation and separable from the posterior thalamus and was totally resected. The patient had an uneventful postoperative course but continues to be somewhat confused. The lesion consisted of a remarkable chronic inflammatory cell infiltrate permeating the pineal lobules and was composed of T and B lymphocytes, macrophages, eosinophils, and mast cells. Immunoperoxidase studies did not demonstrate Langerhans cells, and a search for microorganisms was unrevealing. There was no evidence of neoplasia; results of immunostaining for germ cell markers and other tumor-associated antigens were negative.
authors.affiliation: Neurosurgical Laboratories, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. dnikas@rics.bwh.harvard.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Nikas
authors.forename: U
authors.initials: U
authors.lastname: De Girolami
authors.forename: A A
authors.initials: AA
authors.lastname: Zamani
authors.forename: G S
authors.initials: GS
authors.lastname: Pinkus
authors.forename: L
authors.initials: L
authors.lastname: Bello
authors.forename: M
authors.initials: M
authors.lastname: Kirsch
authors.forename: P M
authors.initials: PM
authors.lastname: Black
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D003221:Confusion / Q000209:etiology; D004660:Encephalitis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008875:Middle Aged; D010870:Pineal Gland / Q000473:pathology* / Q000601:surgery; D011183:Postoperative Complications; D013601:T-Lymphocytes / Q000473:pathology