title: Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.
abstract: Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
authors.affiliation: Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, Gunma, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohashi
authors.forename: A
authors.initials: A
authors.lastname: Ueno
authors.forename: T
authors.initials: T
authors.lastname: Nakao
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: H
authors.initials: H
authors.lastname: Iijima
authors.forename: T
authors.initials: T
authors.lastname: Osawa
mesh_terms: D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
chemical_list: D018926:Anti-Allergic Agents; D001565:Benzoates; C111298:sulochrin