Dopaminergic influence on cardiovascular responses to exercise stress in hypertensive subjects.
Ten hypertensive subjects were studied at the Vargas Medical School in Caracas, Venezuela. They were submitted to submaximal treadmill exercises according to Bruce's protocol under treatment with dopaminergic drugs (metoclopramide, bromocriptine). Before and during submaximal exercises, metoclopramide caused a hypotensive effect accompanied by an increased heart rate, which was blocked by the administration of bromocriptine. We conclude that a probable dopaminergic modulatory influence takes place during exercise.
Blanco
M
M
Clinical Pharmacology Unit, Vargas Medical School, Central University of Venezuela, Caracas.
Hurtado
N
N
Jelambi
I
I
Pérez
G
G
Carrillo
M
M
Gómez
J
J
Bravo
C
C
Gomez
H
H
Collet
H
H
Velasco
M
M
D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D008875:Middle Aged; D012044:Regression Analysis
D015259:Dopamine Agents; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D001971:Bromocriptine; D008787:Metoclopramide; D004298:Dopamine