Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.
Several 5-chlorouracil and 5-chlorocytosine beta-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examined in cell culture.
Pierra
C
C
Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Université de Montpellier II, France.
Gosselin
G
G
Sommadossi
J P
JP
Faraj
A
A
De Clercq
E
E
Balzarini
J
J
Imbach
J L
JL
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D011741:Pyrimidine Nucleosides