[Effect of enkephalins on biosynthesis of myocardial proteins during acute exposure to cold].
Acute cold exposure of organism (4 hours at -20 degrees C) inhibits myocardial protein synthesis and increases cortisol/insulin index in rat blood. Preliminary repeated administration in [D-Ala2, Leu5, Arg6]-enkephalin (dalargin) prevents the decrease of myocardial protein synthesis rate after cold stress and decreases cortisol/insulin ratio. Pretreatment with naloxone at dose of 0.2 mg/kg or 2 mg/kg doesn't eliminate "anabolic" effect of dalargin. "Anabolic" effect of dalargin is suggested to be connected with -opioid receptor stimulation and change in insulin and cortisol secretion.
Lishmanov
Iu B
IuB
Laboratory of Experimental Cardiology, Tomsk Institute Cardiology.
Naryzhnaia
N V
NV
Maslov
L N
LN
D000818:Animals; D003080:Cold Temperature; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism*
D009124:Muscle Proteins; D011500:Protein Synthesis Inhibitors; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie énkefalinov na biosintez miokardial'nykh belkov pri ostrom kholodovom vozdeĭstvii.