Proconvulsive effect of tea (Camellia sinensis) in mice.
Investigations were carried out to evaluate the effect of acute and chronic administration of both black and green tea on three models of experimentally induced convulsions in mice. Tea extract (both black and green) significantly accelerated the onset of convulsion, increased the duration of convulsion and mortality in mice. Since both the extracts failed to alter the GABA level in brain, based on the earlier report that both black and green tea might act on Ca(2+) channels, it can be suggested that the observed proconvulsive effect of tea is not mediated through GABA but through Ca(2+) channels.
Gomes
A
A
Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta - 700032, India.
Das
M
M
Vedasiromoni
J R
JR
Ganguly
D K
DK
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D004597:Electroshock; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013331:Strychnine / Q000494:pharmacology; D013662:Tea / Q000737:chemistry*; D014020:Tissue Extracts / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D003292:Convulsants; D010726:Phosphodiesterase Inhibitors; D013662:Tea; D014020:Tissue Extracts; D002110:Caffeine; D005680:gamma-Aminobutyric Acid; D013331:Strychnine