title: Use of propranolol and potassium iodate in the presurgical management of hyperthyroid cats.
abstract: A prospective study was carried out using a combination of propranolol and potassium iodate to assess whether there were beneficial effects in preparing hyperthyroid cats for surgical thyroidectomy. Group A (n = 11) received propranolol from days 1 to 10, followed by propranolol and potassium iodate from days 11 to 20; group B (n = 10) received the reverse regimen. Blood samples were taken daily for subsequent determination of serum total L-thyroxine (TT4), L-triiodothyronine (TT3) and reverse T3 (rT3) concentrations. The signs of hyperthyroidism improved in all cats over the treatment period. At surgery, 36 per cent of the cats in group A had reference range serum TT4 concentrations, while 89 per cent with initially elevated TT3 concentrations had reference range concentrations. In group B, 10 per cent of the cats had reference range TT4 concentrations, while 75 per cent with initially elevated TT3 concentrations had reference range concentrations. The drug regimen used in group A was better tolerated and more effective and offers an alternative before thyroidectomy in cats that cannot tolerate carbimazole.
authors.affiliation: Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian.
authors.forename: D J
authors.initials: DJ
authors.lastname: Foster
authors.forename: K L
authors.initials: KL
authors.lastname: Thoday
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000601:surgery; D002415:Cats; D004334:Drug Administration Schedule; D005260:Female; D006980:Hyperthyroidism / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D011193:Potassium Iodide / Q000627:therapeutic use*; D011300:Preoperative Care / Q000662:veterinary; D011433:Propranolol / Q000627:therapeutic use*; D011446:Prospective Studies; D012016:Reference Values; D013565:Sympatholytics / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000187:drug effects; D013965:Thyroidectomy / Q000662:veterinary*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
chemical_list: D013565:Sympatholytics; D014284:Triiodothyronine; D011193:Potassium Iodide; D014285:Triiodothyronine, Reverse; D011433:Propranolol; D013974:Thyroxine