title: Basic mechanisms of monogenic inheritance.
abstract: To revive the appreciation of the importance of genetic studies for the understanding of neurologic diseases inherited in a monogenic fashion. After a description of the basic patterns of monogenic inheritance, the importance of linkage studies for the mapping of a disease gene is mentioned. Furthermore, the term linkage disequilibrium is introduced. Finally, several procedures used in current linkage analyses are briefly mentioned, with the aim of identifying the disease gene. The importance of genetic studies of disease families with many members, preferably from isolated surroundings to favor homogeneity, is stressed. However, such analyses can be performed only as a consequence of a close cooperation between clinicians and research scientists.
authors.affiliation: Institut für Immungenetik, Universitätsklinikum Charité, Humboldt-Universität zu Berlin, Germany. andreas.ziegler@charite.de
authors.forename: A
authors.initials: A
authors.lastname: Ziegler
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004827:Epilepsy / Q000235:genetics*; D005190:Family; D005260:Female; D005819:Genetic Markers; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D009146:Music; D009154:Mutation; D010641:Phenotype
chemical_list: D005819:Genetic Markers