title: Cerebellar and basal ganglion involvement in Langerhans cell histiocytosis.
abstract: Langerhans cell histiocytosis (LCH) is a disease of unknown cause characterised by proliferation of histiocytic granulomas in tissues; the primary cerebral manifestation is diabetes insipidus caused by hypothalamic infiltration. We present a patient in whom, except for the absence of high signal on T1 weighting in the posterior pituitary, consistent with central diabetes insipidus, MRI showed no evidence of hypothalamic involvement by histiocytosis, despite the long duration of the disease. However, there was bilateral, symmetrical involvement of the cerebellum and globus pallidus in addition to a calvarial lesion. High signal in the cerebellar white matter on T2-weighted images may represent demyelination, gliosis and cell loss, as previously reported on pathologic examination.
authors.affiliation: Department of Radiology, Hacettepe University Hospital, Ankara, Turkey. cekirgesaatci@superonline.com
authors.forename: I
authors.initials: I
authors.lastname: Saatci
authors.forename: O
authors.initials: O
authors.lastname: Baskan
authors.forename: M
authors.initials: M
authors.lastname: Haliloglu
authors.forename: U
authors.initials: U
authors.lastname: Aydingoz
mesh_terms: D001480:Basal Ganglia Diseases / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002526:Cerebellar Diseases / Q000473:pathology*; D002675:Child, Preschool; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male