[Myocardial contractile and calcium transport function after severe burn injury].
OBJECTIVE
This study examined the changes in myocardial calcium transport function and what roles it played in cardiac dysfunction after severe burn injury.


METHODS
Contraction relaxation properties of the left ventricule (LV) were studied in isolated heart preparations of Wistar rat 3, 8, 24 hours after 30% TBSA full thickness burn. Sarcoplasmic reticulum (SR) calcium transport function was measured by millipore filtration technique.


RESULTS
The maximal rates of LV pressure elevation (+ dp/ dtmax) and depression (-dp/dtmax) in burn group were significantly lower than that in control group (P < 0.01). The initial rate and capacity of calcium uptake by SR decreased markedly in burn group than in control group (P < 0.01). In addition, calcium dependent ATPase activity and coupling ratio of SR were also markedly depressed.


CONCLUSIONS
SR calcium transport function depression was closely related to cardiac contractile dysfunction, and the former is one of the important mechanism for cardiac contractile dysfunction after severe burn injury.
Yang
J
J
Department of Burns and Plastic Surgery, Bethune International Peace Hospital, Shijiazhuang.
Yang
Z
Z
Chen
F
F
D000818:Animals; D001693:Biological Transport, Active; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D005260:Female; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D016277:Ventricular Function, Left
D002118:Calcium