Secondary T-acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia.
A 34-year-old man with chronic myeloid leukaemia (CML) firstly developed a lymphoid blast crisis of B-cell type. After a second chronic phase which lasted for > 4 years with maintenance chemotherapy of hydroxyurea, 6-mercaptopurine and methotrexate, he developed a T-cell acute lymphoblastic leukaemia of TcR-gammadelta+ type. Cytogenetic analysis revealed disappearance of the t(9;22) translocation and appearance of new abnormalities consistent with the diagnosis secondary acute leukaemia. To our knowledge, secondary leukaemia in CML has not previously been reported.
Dawson
L
L
Department of Internal Medicine, Leiden University Medical Centre, The Netherlands.
Slater
R
R
Hagemeijer
A
A
Langerak
A W
AW
Willemze
R
R
Kluin-Nelemans
J C
JC
D000328:Adult; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D008297:Male