title: Myocardial preconditioning: basic concepts and potential mechanisms.
abstract: Preconditioning is a phenomenon, where brief periods of stress such as ischemia, heat shock or certain pharmacological agents make the heart tolerant to subsequent lethal ischemic injury. Preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel and expression of a number of protective proteins. In this review, the potential role of these mechanisms is discussed.
authors.affiliation: Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
authors.forename: S
authors.initials: S
authors.lastname: Okubo
authors.forename: L
authors.initials: L
authors.lastname: Xi
authors.forename: N L
authors.initials: NL
authors.lastname: Bernardo
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: R C
authors.initials: RC
authors.lastname: Kukreja
mesh_terms: D000818:Animals; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008955:Models, Cardiovascular