title: [A case of a aggressive giant-cell tumor with multiple bone metastases].
abstract: OBJECTIVE
  Giant-cell tumor are known for local recurrence. Metastases are rare (2 p. 100), and generally located in the lung. We present a case with multiple bone metastases and rapid course.
  
  
  RESULTS
  A 45-year-old man presented a 5 cm giant-cell tumor of his right distal tibia and two other localisation in the fifth and sixth cervical vertebral bodies. He underwent a resection of the distal tibia and reconstruction with a controlateral free vascularized fibula. The bodies of the fifth and sixth cervical vertebral were resected and replaced by an iliac crest graft. Other localisations appeared in iliac right crest, in the posterior wall of the cotyle and in the second, third and fourth cervical vertebral bodies. Chemotherapy was administered and clinical signs regressed but eight months later the patient presented a recurrence of his tumor in the distal tibia with new localisation in the left fifth rib, in the right clavicle, in the frontal bone, in right ischio-pubal branch and in the right proximal femur. A new chemotherapy was performed but had little effect and probably hasved dubic death 13 month after the first symptom.
  
  
  CONCLUSIONS
  The present observation is characterised by the large number of localisations (13; the highest number found in the literature was 11 localisations) and by the rapidity of the clinical course. Low grade giant-cell tumors generally give benign metastase with a course lasting several years. The chemotherapy helpt us to slow the progression of the lesions but was unable to prevent the development of new localisation and the recurrence in the distal tibia. More over, its toxicity could have caused the death of the patient.
  
  
  CONCLUSIONS
  We present the case of one patient who presented a giant-cell tumor with unusual presentation: multiple bony metastases with rapidly fatal outcome.
authors.affiliation: Centre de Traumatologie et d'Orthopédie de Strasbourg 10, Illkirch.
authors.forename: M
authors.initials: M
authors.lastname: De Smedt
authors.forename: G
authors.initials: G
authors.lastname: Copin
authors.forename: C
authors.initials: C
authors.lastname: Boeri
authors.forename: J C
authors.initials: JC
authors.lastname: Dosch
authors.forename: M
authors.initials: M
authors.lastname: Dupuis
authors.forename: L
authors.initials: L
authors.lastname: Marcellin
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D002574:Cervical Vertebrae; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D013977:Tibia; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents
vernacular_title: A propos d'un cas de tumeur à cellules géantes d'évolution rapide avec métastases osseuses multiples.