[Influence of escharectomy during burn shock stage upon the changes in endothelin and NO].
OBJECTIVE
To observe influence of escharectomy during and after burn shock stage upon the changes in plasma ET and NO.


METHODS
35% TBSA full-thickness burn was produced in pigs, which were divided into two groups. Group S was a group undergoing escharectomy during burn shock stage at 24 h postburn. Group C was a group receiving escharectomy at 96 h after injury. ET and NO were determined and ET/NO was calculated.


RESULTS
The levels of ET and NO were higher after injury than before injury in both groups. The level of ET was lower significantly in group S than in group C from 96 h postburn on. The level of NO was higher in group S than in group C. The ET/NO was lower in group S than in group C from PBH 24 on.


CONCLUSIONS
Escharectomy during burn shock stage was beneficial in reducing injury of endothelial cells, decreasing exudation and edema, decreasing tissue hypoxia and improving microcirculation.
Sun
S
S
Burn Institute of People's Liberation Army, 304th Hospital, Beijing.
He
L
L
Guo
Z
Z
D000818:Animals; D002056:Burns / Q000097:blood / Q000601:surgery*; D016232:Endothelins / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D012774:Shock, Traumatic / Q000097:blood / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature
D016232:Endothelins; D009569:Nitric Oxide