title: Immunological evidence for a bacterial toxin aetiology in sudden infant death syndrome.
abstract: Toxin-specific antibodies to clostridial, enterobacterial and staphylococcal toxins implicated in sudden infant death syndrome were studied in sera from sudden infant death syndrome infants and a comparison group of infants (babies with phenylketonuria). The results indicated a higher proportion of sera from sudden infant death syndrome infants contained IgA that bound to clostridial and enterobacterial toxins but a higher proportion of sera from the phenylketonuria comparison group contained IgA that bound staphylococcal toxins. The higher proportion of serum samples with IgG and IgM in the healthy comparison babies serum probably indicated immunity in this group of babies to these toxins. The effect of gender and age had a minimal effect on the incidence of these antibodies. The presence of toxin-specific antibodies in sudden infant death syndrome and the of comparison infants suggests that all infants are exposed to these toxins and most babies successfully overcome the toxic challenge. Some infants with predisposing risk factors (temperature change, smoking, infection, immune development, sleeping position, etc.) that could affect the baby's immune competency could succumb to these and possibly other toxins. This immunological evidence further strengthens the view that bacterial toxins are a significant cause of sudden infant death syndrome.
authors.affiliation: Department of Microbiology and Infectious Diseases, Concord Repatriation General Hospital, NSW, Australia. steven@micr.crg.cs.nsw.gov.au
authors.forename: S
authors.initials: S
authors.lastname: Siarakas
authors.forename: A J
authors.initials: AJ
authors.lastname: Brown
authors.forename: W G
authors.initials: WG
authors.lastname: Murrell
mesh_terms: D017677:Age Distribution; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000032:analysis* / Q000276:immunology*; D016360:Clostridioides difficile / Q000276:immunology; D003016:Clostridium perfringens / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010661:Phenylketonurias / Q000276:immunology; D017678:Sex Distribution; D013210:Staphylococcus / Q000276:immunology; D013398:Sudden Infant Death / Q000209:etiology* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001427:Bacterial Toxins