Mechanisms of the effect of xenobiotics on bacterial bioluminescence.
The influence of xenobiotics on the bioluminescent enzyme system is considered in terms of molecular action on the primary physicochemical processes-energy, electron and hydrogen (e(-) + H(+)) transduction. Dyes, non-fluorescent chemically inert organic compounds, redox-active organic compounds and metallic salts were investigated. The influence of the different xenobiotics depends in a complex way on physicochemical characteristics of the xenobiotic molecules (spectral-luminescent characteristics, electron-acceptation energy and redox potential).
Kudryasheva
N S
NS
Institute of Biophysics SB RAS, Krasnoyarsk 660036, Russia. kudr@bbl.krasnoyarsk.su
D001419:Bacteria / Q000187:drug effects*; D018407:Bacterial Physiological Phenomena; D007700:Kinetics; D008156:Luciferases / Q000187:drug effects / Q000378:metabolism*; D049449:Luminescence; D011809:Quinones / Q000494:pharmacology; D015262:Xenobiotics / Q000494:pharmacology*
D011809:Quinones; D015262:Xenobiotics; D008156:Luciferases