title: Synthesis of novel carbocyclic nucleosides with a modified cyclopentane ring and evaluation of their antiviral activity.
abstract: New carbocyclic nucleosides with purine (compounds 2a-2c), 8-azapurine (compounds 2d and 2e) or pyrimidine (compound 3) as base were prepared and assayed for in vitro activity.
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Nieto
authors.forename: M J
authors.initials: MJ
authors.lastname: Figueira
authors.forename: J M
authors.initials: JM
authors.lastname: Blanco
authors.forename: O
authors.initials: O
authors.lastname: Caamaño
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D006367:HeLa Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides