Diverse initiation in a conserved left-right pathway?
Preceding stereotypical left-right asymmetric morphogenesis, asymmetric gene expression patterns of nodal and pitx2 are very similar in major groups of vertebrates. I propose that these conserved expression patterns are indicative of 'left-right' phylotypic stages' of development. It is not known whether these patterns are initiated by conserved or divergent developmental mechanisms.
Yost
H J
HJ
Huntsman Cancer Institute, University of Utah, 2000 E. North Campus Drive, Room 452, Salt Lake City, Utah 84112-5550, USA. joseph.yost@hci.utah.edu
D000818:Animals; D005314:Embryonic and Fetal Development; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm