title: [Papillomavirus-induced anogenital lesions in 121 HIV seropositive men. Clinical, histological, viral study, and evolution].
abstract: OBJECTIVE
  To determine the prevalence of the Human Papillomavirus (HPV) in Human Immunodeficiency Virus (HIV) infected men, using clinical examination and molecular hybridization in situ.
  
  
  METHODS
  From May 1995 to May 1997 we studied the prevalence, clinical and histological characteristics, the types and the evolution of the HPV lesions among 121 HIV-infected men. The HPV DNA was determined by molecular hybridization in situ, using biotinylated probes which recognized HPV types 6/11, 16/18 and 31/33/35 in 79 p. 100 (5/19) of the patients (17 biopsies).
  
  
  RESULTS
  Sixteen per cent (19/121) of the patients are HPV infected: genital warts in 37 p. 100 (7/19), anal warts in 37 p. 100 (7/19), and ano-genital warts in 26 p. 100 (5/19) of the patients. In every case of anal codyloma, intracanalar lesions were found. In 47 p. 100 (9/19) of the cases, histological exam showed an intra-epithelial neoplasia. The HPV types 6/11, 16/18 and 31/33/51 were positive in 53 p. 100 (9/17), 35 p. 100 (6/17) and 35 p. 100 (6/17) biopsies respectively. High-risk types of HPV have been noted in 71 p. 100 (12/17) of the biopsies. The evolution of the clinical lesions was: recovering in 47 p. 100 (9/19) of the patients (after 3 months of treatment), recurrence in 16 p. 100 (3/19) of the anal warts (after 1 to 3 months of treatment), stabilization in 16 p. 100 (3/19) of the genital warts (after 6 months of treatment) and extension in 11 p. 100 (2/19) of the anogenital warts (after 3 months of treatment).
  
  
  CONCLUSIONS
  The high prevalence of condyloma and dysplasia emphasizes the importance of the anogenital exam in HIV-positive patients. In case of anal lesions, anuscopy and biopsy are required. We insist on the need to closely follow these patients with HPV lesions in order to adapt treatment. Anal cytology and HPV-DNA detection by Hybrid Capture Assay, should be developed for screening and prevention of the malignant transformation of HPV lesions in this population.
authors.affiliation: Service de Dermatologie II, CHU St Jacques, Besançon.
authors.forename: J M
authors.initials: JM
authors.lastname: Voltz
authors.forename: C
authors.initials: C
authors.lastname: Drobacheff
authors.forename: C
authors.initials: C
authors.lastname: Derancourt
authors.forename: S
authors.initials: S
authors.lastname: Coumes-Marquet
authors.forename: C
authors.initials: C
authors.lastname: Mougin
authors.forename: R
authors.initials: R
authors.lastname: Laurent
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D000328:Adult; D001706:Biopsy; D001727:Bisexuality; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D015344:DNA Probes, HPV; D005500:Follow-Up Studies; D005832:Genital Diseases, Male / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D018451:Homosexuality, Male; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D012867:Skin / Q000473:pathology / Q000821:virology; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
chemical_list: D015344:DNA Probes, HPV
vernacular_title: Lésions anogénitales à papillomavirus chez 121 hommes séropositifs pour le VIH. Etude clinique, histologique, virale, et évolution.