title: Effect of processed and non-processed coffee samples on gastric potential difference. Study with healthy male Helicobacter pylori-positive and Helicobacter pylori-negative volunteers.
abstract: In an open trial with 18 healthy male volunteers (21-45 years old) the effect of processed (test) and non-processed (reference) coffee samples of same origin on the gastric potential difference (GPD) was studied. Test coffee samples were processed with the patented "Darboven improvement procedure" before roasting. All treatment groups were subdivided according to the Helicobacter pylori status of the volunteers. The evaluation of the target parameters Reizindex (RI), area under the baseline (AUB), maximum potential difference (Pdmax) and total time (ttot) revealed a significant lower RI (p = 0.0282) and AUB (p = 0.0136), and a significant shorter ttot (p = 0.0286) for the processed coffee. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and pancreatic peptides showed a comparable marked increase of the arithmetic mean with both coffee samples, however, being more intense in the Helicobacter pylori-positive subgroup than in the Helicobacter pylori-negative subgroup. No negative findings concerning tolerability and safety could be seen. In conclusion, the test coffee samples processed with a new method to improve the stomach mucosal irritation-potential of coffee charges revealed a remarkably lower stomach mucosal irritation.
authors.affiliation: Medical Department Phase I, Institut für klinische Pharmakologie Bobenheim, Grünstadt, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ehrlich
authors.forename: P W
authors.initials: PW
authors.lastname: Lücker
authors.forename: A
authors.initials: A
authors.lastname: Schaefer
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D003069:Coffee / Q000009:adverse effects*; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D007509:Irritants; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
chemical_list: D008076:Cholesterol, HDL; D003069:Coffee; D007509:Irritants; D010191:Pancreatic Polypeptide