An economical synthesis of famciclovir.
An economical synthesis of famciclovir from N-2-acetyl-7-benzylguanine by a novel regioselective alkylation with the diester cyclopropane compound was developed.
Hijiya
T
T
AminoScience Laboratories, Ajinomoto Co. Inc., Kawasaki, Japan.
Yamashita
K
K
Kojima
M
M
Uchida
Y
Y
Katayama
S
S
Torii
T
T
Shiragami
H
H
Izawa
K
K
D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis*; D003365:Costs and Cost Analysis; D000077595:Famciclovir
D000998:Antiviral Agents; D015075:2-Aminopurine; D000077595:Famciclovir