Derivatives of L-adenosine and L-guanosine as substrates for human deoxycytidine kinase.
A series of analogues of L-adenosine and of L-guanosine, including beta-L-dA, beta-L-Ado, beta-L-araA, and beta-L-dG, have been shown to be substrates of human deoxycytidine kinase thus demonstrating the complete lack of enantioselectivity of this enzyme.
Gaubert
G
G
Laboratoire de Chimie Bioorganique, UMR 5625 du CNRS, Université Montpellier II, France.
Gosselin
G
G
Imbach
J L
JL
Eriksson
S
S
Maury
G
G
D000241:Adenosine / Q000378:metabolism*; D003842:Deoxycytidine Kinase / Q000378:metabolism*; D006151:Guanosine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011994:Recombinant Proteins / Q000378:metabolism; D013237:Stereoisomerism; D013379:Substrate Specificity
D011994:Recombinant Proteins; D006151:Guanosine; D003842:Deoxycytidine Kinase; D000241:Adenosine