The role of protective CD8+ T cells in resistance of BALB/c mice to Theiler's murine encephalomyelitis virus-induced demyelinating disease: regulatory vs. lytic.
Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease (TMEV-IDD) is an excellent model for human multiple sclerosis. Within the BALB/c strain, BALB/cAnNCr mice are susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice become susceptible when irradiated. Adoptive transfer of CD8+ splenic T cells from resistant BALB/cByJ donors protect irradiated BALB/cByJ, as well as BALB/cAnNCr recipients, from development of TMEV-IDD. Anti-TMEV CTL activities in BALB/cAnNCr, BALB/cByJ and irradiated BALB/cByJ mice are comparable. A population of splenic CD4+ T cells in BALB/cByJ donors has also been identified which can protect both susceptible BALB/cAnNCr and irradiated BALB/cByJ recipients from TMEV-IDD via adoptive transfer.
Nicholson
S M
SM
Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, IL 60611, USA.
Haynes
L M
LM
Vanderlugt
C L
CL
Miller
S D
SD
Melvold
R W
RW
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D017690:Cell Transplantation; D003711:Demyelinating Diseases / Q000276:immunology* / Q000821:virology; D004198:Disease Susceptibility; D005354:Fibrosarcoma; D005720:Gamma Rays; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015213:Neuroimmunomodulation / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects; D017945:Theilovirus / Q000276:immunology*; D013934:Thymectomy; D014407:Tumor Cells, Cultured