title: Synthesis of probes for the active site of leucine dehydrogenase.
abstract: A series of novel 3-substituted 2-oxobutanoic acids were prepared and incubated with leucine dehydrogenase giving in one case both a kinetic resolution at C-3 and reductive amination of the ketone. This is the first example of an amino acid dehydrogenase catalysed kinetic resolution and reductive amination.
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, UK.
authors.forename: A
authors.initials: A
authors.lastname: Sutherland
authors.forename: C L
authors.initials: CL
authors.lastname: Willis
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D006868:Hydrolysis; D050803:Leucine Dehydrogenase; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D015335:Molecular Probes / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013379:Substrate Specificity; D013912:Threonine / Q000138:chemical synthesis
chemical_list: D015335:Molecular Probes; D013912:Threonine; D000594:Amino Acid Oxidoreductases; D050803:Leucine Dehydrogenase; D008049:Lipase