Urinary glycosaminoglycans in recurrent urinary tract infections in kidney transplant patients.
Glycosaminoglycans have generalized antibacterial anti-adherent activity, and cooperate with secretory immunoglobulin-A in anti-infection defense mechanisms of the urinary tract. Cyclosporin A modulates T-lymphocytes and fibroblast functions. In this report we analyze urinary glycosaminoglycans and secretory immunoglobulin-A in renal transplant patients with recurrent urinary tract infections treated with cyclosporin. The results show a significant decrease of total glycosaminoglycans and secretory immunoglobulin-A in recurrent urinary tract infections which is unrelated to cyclosporin treatment. The data support the hypothesis that recurrent urinary tract infections may be the consequence of a genetic pathology rather than cyclosporin-induced alterations.
Stabellini
G
G
Calastrini
C
C
Gilli
P
P
Bedani
P L
PL
D000368:Aged; D003404:Creatinine / Q000652:urine; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006801:Humans; D007070:Immunoglobulin A / Q000652:urine; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014552:Urinary Tract Infections / Q000652:urine*
D006025:Glycosaminoglycans; D007070:Immunoglobulin A; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine