title: [Autoantibodies in the pathogenesis and diagnosis of insulin-dependent diabetes mellitus].
abstract: Insulin-dependent diabetes mellitus is considered an autoimmune disease. The immune response is targeted on autoantigens of B-cells of the islets of Langerhans. The most important autoantigens are glutamic acid decarboxylase, protein tyrosine phosphatase and insulin. Despite the fact that their role in the pathogenesis of insulin-dependent diabetes mellitus is not clear, they are used in diagnosis and can identify subjects at high risk for the development of the disease.
authors.affiliation: III. interní klinika 1. LF UK a VFN, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Prázný
authors.forename: J
authors.initials: J
authors.lastname: Skrha
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D006801:Humans
chemical_list: D001323:Autoantibodies
vernacular_title: Autoprotilátky v patogenezi a diagnostice inzulin-dependentního diabetes mellitus.