Polarity determination in the Drosophila eye.
In the Drosophila eye, photoreceptor clusters are arranged with mirror-image symmetry about the dorso-ventral midline. Recent work indicates critical rôles for Wingless and JAK/STAT signalling in setting up long-range gradients of positional information that determine this symmetry. Furthermore, important functions have been elucidated for Notch signalling in specifying the position of the axis of symmetry and then later in development in interpreting gradient information.
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Developmental Genetics Programme, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
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D000818:Animals; D016764:Cell Polarity; D004330:Drosophila / Q000166:cytology / Q000196:embryology*; D029721:Drosophila Proteins; D005123:Eye / Q000166:cytology / Q000196:embryology*; D051157:Frizzled Receptors; D008565:Membrane Proteins / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D051880:Receptors, Notch; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D051880:Receptors, Notch; D014157:Transcription Factors; D051155:Wnt1 Protein; C058784:fz protein, Drosophila; C074622:wg protein, Drosophila; D011505:Protein-Tyrosine Kinases