title: No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.
abstract: Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
authors.affiliation: Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: MacLeod
authors.forename: M T
authors.initials: MT
authors.lastname: Dahiyat
authors.forename: A
authors.initials: A
authors.lastname: Cumming
authors.forename: D
authors.initials: D
authors.lastname: Meiklejohn
authors.forename: D
authors.initials: D
authors.lastname: Shaw
authors.forename: D
authors.initials: D
authors.lastname: St Clair
mesh_terms: D000368:Aged; D000483:Alleles; D001224:Aspartic Acid; D002545:Brain Ischemia / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000235:genetics*; D005260:Female; D005838:Genotype; D018698:Glutamic Acid; D006801:Humans; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; D019001:Nitric Oxide Synthase