title: Sensitization to allergens of house-dust mite in adults with atopic dermatitis in a cold temperature region.
abstract: BACKGROUND
  An IgE-mediated contact reaction to airborne allergens has been suggested as one important pathogenetic mechanism in atopic dermatitis (AD). The house-dust mite (HDM) might be a common allergen involved. In Scandinavia, sensitization to HDM has been rare, probably because of the cold, dry climate. However, recent studies indicate high levels of domestic mites and HDM allergen in 15-20% of homes in central and northern Sweden.
  
  
  METHODS
  To evaluate the importance of the HDM in patients with AD in the Stockholm region, we screened 81 adult Stockholm residents with AD, for the prevalence and degree of sensitization to the HDM, according to specific IgE (RAST), skin prick test (SPT), and atopy patch test (APT). We also assessed the HDM exposure in their homes and correlated the results with clinical history, severity of the dermatitis, and type of residence during childhood and today.
  
  
  RESULTS
  The sensitization rate to HDM was high (56% according to RAST, 24% according to SPT, and 47% according to APT), and 20% of the patients were exposed to HDM allergens in their beds. Mite exposure seemed to aggravate the dermatitis in highly sensitized patients.
  
  
  CONCLUSIONS
  The results indicate that we have to take the HDM into account when discussing aggravating factors in adult patients with AD in the Stockholm region.
authors.affiliation: Department of Dermatology, Stockholm Söder Hospital, Karolinska Institute, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Holm
authors.forename: M
authors.initials: M
authors.lastname: van Hage-Hamsten
authors.forename: S
authors.initials: S
authors.lastname: Ohman
authors.forename: A
authors.initials: A
authors.lastname: Scheynius
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000276:immunology*; D000818:Animals; D039741:Antigens, Dermatophagoides; D003081:Cold Climate; D003876:Dermatitis, Atopic / Q000276:immunology*; D004391:Dust; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006798:Housing; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology*; D010328:Patch Tests; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012882:Skin Tests; D013548:Sweden
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins; D007073:Immunoglobulin E