Cancer-associated retinopathy during treatment for small-cell lung carcinoma.
A 70-year-old woman with small-cell lung carcinoma (c-T4N2M0) was treated by six courses of combination chemotherapy (carboplatin and etoposide). After two weeks, she complained of a sense of darkness and night blindness. A Western blot analysis showed that the patient's serum bound with the recombinant 23-kDa retinal cancer-associated retinopathy (CAR) antigen at 1:1,000 dilution. Her visual acuity became so poor that she could only recognise a hand motion at 50 cm despite treatment with corticosteroids and combination chemotherapy. The patient was diagnosed as having a rare type of CAR because CAR is usually found before the diagnosis of primary cancer.
Kashiwabara
K
K
Respiratory Department, Taragi Municipal Hospital, Kumamoto.
Nakamura
H
H
Kishi
K
K
Yagyu
H
H
Sarashina
G
G
Kobayashi
K
K
Matsuoka
T
T
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002135:Calcium-Binding Proteins / Q000097:blood; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy; D005047:Etoposide / Q000008:administration & dosage; D005136:Eye Proteins; D005260:Female; D051597:Hippocalcin; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008074:Lipoproteins; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D051603:Recoverin; D012164:Retinal Diseases / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D015354:Vision, Low / Q000209:etiology / Q000503:physiopathology; D014792:Visual Acuity
D000305:Adrenal Cortex Hormones; D000951:Antigens, Neoplasm; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D007166:Immunosuppressive Agents; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D005047:Etoposide; D016190:Carboplatin