Anti-tumor-promoting effects of phenylpropanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All tested compounds in this study showed inhibitory activity against the EBV activation even at 1 x 10 mol ratio without any cytotoxicity. Among 12 phenylpropanoids tested, boropinal-C (1), boropinol-A (5), boropinol-C (9) and 3-(3'-methoxy-4'-prenyloxy)phenyl-1-propene (10), all having a 4'-(3-methylbut-2-enyloxy) group, a so-called prenyloxy group, showed more potent activities. Furthermore, 3-(3'-methoxy-4'-prenyloxy)phenyl-1-propene (10) also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that certain phenylpropanoids might be valuable anti-tumor promoters.
Ito
C
C
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya, Japan.
Itoigawa
M
M
Furukawa
H
H
Ichiishi
E
E
Mukainaka
T
T
Okuda
M
M
Ogata
M
M
Tokuda
H
H
Nishino
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D002273:Carcinogens / Q000494:pharmacology; D019309:Epstein-Barr Virus Nuclear Antigens / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010666:Phenylpropionates / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use*; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000970:Antineoplastic Agents; D002273:Carcinogens; D019309:Epstein-Barr Virus Nuclear Antigens; D010666:Phenylpropionates; D013755:Tetradecanoylphorbol Acetate