title: Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients.
abstract: BACKGROUND
  Bioflavonoids and ascorbic acid have been shown to increase capillary resistance and to mediate potent antioxidative radical scavenging activities.
  
  
  OBJECTIVE
  We evaluated the clinical effect of oral bioflavonoids and ascorbic acid in patients with chronic progressive pigmented purpura (PPP).
  
  
  METHODS
  In an open pilot study, oral rutoside (50 mg twice a day) and ascorbic acid (500 mg twice a day) were administered to 3 patients with chronic PPP.
  
  
  RESULTS
  At the end of the 4-week treatment period, complete clearance of the skin lesions was achieved in all 3 patients. No adverse reactions were noted. All patients remained free of lesions at the end of 3 months after treatment.
  
  
  CONCLUSIONS
  Our results suggest a beneficial effect of bioflavonoids in combination with ascorbic acid on PPP. Because the disease is mostly resistant to other treatment modalities, placebo-controlled studies are necessary to determine the usefulness of this therapy in PPP.
authors.affiliation: Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Reinhold
authors.forename: S
authors.initials: S
authors.lastname: Seiter
authors.forename: S
authors.initials: S
authors.lastname: Ugurel
authors.forename: W
authors.initials: W
authors.lastname: Tilgen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D010859:Pigmentation Disorders / Q000188:drug therapy*; D010865:Pilot Projects; D011693:Purpura / Q000188:drug therapy*; D012431:Rutin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D005419:Flavonoids; C056067:rutin sulfate; D012431:Rutin; D001205:Ascorbic Acid