Diuretic activity of an aqueous extract of Phyllanthus sellowianus.
Phyllanthus sellowianus Muell. Arg. (Euphorbiaceae) is used widely as a hypoglycemic and diuretic agent in South American folk medicine. In order to assess the diuretic activity of this plant, test animals were treated with a single oral administration of an aqueous extract (5% w/v) of the stem bark of P. sellowianus (400 mg/kg body weight), which produced after 8 h a significant increase in the urinary excretion. In the studies on acute toxicity in mice neither mortality nor neurobehavioral or autonomic profile changes could be observed.
Hnatyszyn
O
O
Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Universidad de Buenos Aires, Argentina. ohnatys@huemul.ffyb.uba.ar
Miño
J
J
Gorzalczany
S
S
Opezzo
J
J
Ferraro
G
G
Coussio
J
J
Acevedo
C
C
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004232:Diuretics / Q000302:isolation & purification / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D006852:Hydrochlorothiazide / Q000494:pharmacology; D008297:Male; D051379:Mice; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology; D013020:South America
D004232:Diuretics; D004573:Electrolytes; D010936:Plant Extracts; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide