Amelioration of acromegaly after pituitary infarction due to gastrointestinal hemorrhage from gastric ulcer.
We report a rare case of acromegaly in which pituitary infarction possibly developed in a GH-producing pituitary adenoma following gastrointestinal bleeding from peptic ulcer. In this case, pituitary infarction resulted in spontaneous remission of acromegaly associated with diabetes mellitus. In addition, detailed histological investigation revealed that clinically silent pituitary apoplexy was mainly an acute ischemic event which occurred recently in a GH-producing adenoma. This event led to massive coagulation necrosis of the tumor and endocrinological improvement.
Imaki
T
T
Second Department of Medicine, Tokyo Women's Medical College, Japan.
Yamada
S
S
Harada
S
S
Tsuchiya
M
M
Sano
T
T
Demura
H
H
D000172:Acromegaly / Q000209:etiology*; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000150:complications* / Q000175:diagnosis; D006442:Glycated Hemoglobin / Q000032:analysis; D007987:Gonadotropin-Releasing Hormone; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007238:Infarction / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000098:blood supply*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D012075:Remission, Spontaneous; D013276:Stomach Ulcer / Q000150:complications* / Q000175:diagnosis; D013973:Thyrotropin-Releasing Hormone
D006442:Glycated Hemoglobin; D007987:Gonadotropin-Releasing Hormone; D019382:Human Growth Hormone; D013973:Thyrotropin-Releasing Hormone