[Hypertension and mineralocorticoids. Usefulness of renin and aldosterone measurements].
Recently, some genetic forms of hypertension have been well characterized. These forms can be globally called mineralocorticoid hypertension and are due to different alterations of the renin-angiotensin-aldosterone system (SRAA). Among these, classic primary hyperaldosteronism and its glucocorticoid remediable variety, in which hypertension is secondary to aldosterone production, must be considered. There are also conditions in which mineralocorticoid activity does not depend on aldosterone production. These conditions generate a hyporeninemic hyperaldosteronism, observed in Liddle syndrome, apparent mineralocorticoid hypertension, 11- and 17-hydroxylase deficiency, among others. The detection of these forms of hypertension is only feasible if the renin-angiotensin-aldosterone system is assessed, measuring renin and aldosterone levels. This article reviews these forms of hypertension, their clinical workup and their relevance in the usual hypertensive patients.
Fardella
C E
CE
Departamentos de Endocrinología y Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile.
Montero
J
J
Mosso
L
L
D000450:Aldosterone / Q000097:blood; D004573:Electrolytes / Q000097:blood; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D006973:Hypertension / Q000209:etiology*; D006994:Hypoaldosteronism / Q000503:physiopathology; D008901:Mineralocorticoids / Q000235:genetics / Q000502:physiology; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology
D004573:Electrolytes; D008901:Mineralocorticoids; D000450:Aldosterone; D012083:Renin
Hipertensión arterial y mineralocorticoides: utilidad de las mediciones de renina y aldosterona.