Conjunctival epithelial neoplasias in organ transplant patients receiving cyclosporine therapy.
OBJECTIVE
To report two cases of conjunctival epithelial neoplasias occurring after long-term systemic cyclosporine therapy in organ transplant recipients.


METHODS
Case report. Each patient underwent an excision of an extensive limbal conjunctival lesion, followed by a histopathologic analysis.


RESULTS
Histopathologic examination results revealed a carcinoma in situ and a squamous cell carcinoma in patients 1 and 2, respectively. Recurrence occurred in patient 1, who needed topical mitomycin C 0.02% treatment. No recurrence was observed in patient 2 after a follow-up of 24 months.


CONCLUSIONS
To our knowledge, these are the first reported cases of its kind after longterm systemic cyclosporine therapy. Further studies will be needed to determine the exact role of cyclosporine in the induction of conjunctival epithelial neoplasias and the need for regular ophthalmologic examination of transplant recipients.
Macarez
R
R
Department of Ophthalmology, Hôpital Augustin Morvan, Brest Medical University, France. Joseph.Colin@univ-brest.fr
Bossis
S
S
Robinet
A
A
Le Callonnec
A
A
Charlin
J F
JF
Colin
J
J
D002278:Carcinoma in Situ / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003230:Conjunctival Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D003452:Cryosurgery; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013508:Ophthalmologic Surgical Procedures
D007166:Immunosuppressive Agents; D016572:Cyclosporine