Antiinflammatory effects of phosphonomethoxyethyl analogues of adenine in a model of adjuvant arthritis.
The 9-(2-phosphonomethoxyethyl)adenine (PMEA) and its more bioavailable bis(pivaloyloxymethyl) ester, (bis-POM-PMEA), applied s.c. at doses of 5-50 mg/kg, profoundly suppress symptoms of rat adjuvant arthritis, such as paw swelling, sple-nomegaly, fibroadhesive perisplenitis and systemic NO levels. The 9-(2-phosphonomethoxypropyl)adenine, PMPA and bis-POC-PMPA are ineffective. The antiarthritic effect does not depend on the influence of the drugs on macrophage NO production.
Franková
D
D
Institute of Pharmacology, Academy of Sciences, Prague, Czech Republic.
Zídek
Z
Z
Buchar
E
E
Jiøièka
Z
Z
Holý
A
A
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D009569:Nitric Oxide / Q000096:biosynthesis; D063065:Organophosphonates; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D063065:Organophosphonates; C089823:bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine; D009569:Nitric Oxide; C053001:adefovir; D000225:Adenine