Study of stomach motility using the relaxation of magnetic tracers.
Magnetic tracers can be observed in the interior of the human body to give information about their quantity, position and state of order. With the aim of detecting and studying the degree of disorder of these tracers after they have been previously magnetized inside the stomach, a system composed of magnetization coils and magnetic detectors was developed. Helmholtz coils of diameter 84 cm were used to magnetize the sample and the remanent magnetization (RM) was detected with two first-order gradiometric fluxgate arrays each with a 15 cm base line, sensitivity of 0.5 nT and common mode rejection (CMR) of at least 10. The system allows simultaneous measurement in the anterior and posterior projections of the stomach. Measurements of the time evolution of the RM were performed in vitro and in normal subjects after the ingestion of a test meal labelled with magnetic particles. The data were fitted with an exponential curve and the relaxation time tau was obtained. Initial studies were performed to ascertain the action of a drug that is known to affect the gastric motility, showing that the decay of the remanent magnetization was indeed due to stomach contractions.
Carneiro
A A
AA
Departamento de Física e Matemética-FFCLRP, University of São Paulo, Ribeirão Preto, SP, Brazil.
Baffa
O
O
Oliveira
R B
RB
D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008280:Magnetics; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D013270:Stomach / Q000502:physiology*
D002086:Butylscopolammonium Bromide