title: The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections.
abstract: Helminth infections induce the production of type 2 cytokines, which contribute both to expulsion of the worms and inflammatory responses that can either protect or damage the host. Although IL-4 has been considered the most critical cytokine for both inflammation and protective immunity, recent observations indicate that IL-13 - a related cytokine - can have equal or even greater importance than IL-4 in inflammatory responses and host protection against infection.
authors.affiliation: Division of Immunology, University of Cincinnati College of Medicine, PO Box 670563, OH 45267-0563, USA. ffinkelman@mem.po.com
authors.forename: F D
authors.initials: FD
authors.lastname: Finkelman
authors.forename: T A
authors.initials: TA
authors.lastname: Wynn
authors.forename: D D
authors.initials: DD
authors.lastname: Donaldson
authors.forename: J F
authors.initials: JF
authors.lastname: Urban
mesh_terms: D000818:Animals; D004064:Digestive System / Q000469:parasitology; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D018793:Interleukin-13 / Q000502:physiology*; D015847:Interleukin-4 / Q000502:physiology; D009349:Nematode Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018793:Interleukin-13; D015847:Interleukin-4