title: Alcohol intake and brain [3H]muscimol binding sites in alcohol-preferring and non-preferring rats.
abstract: The present study has employed in vitro autoradiography to determine the distribution and density of [3H]muscimol binding sites in the brains of alcohol high-preferring line of rats (WHP) and alcohol low-preferring line of rats (WLP). While the density of [3H]muscimol binding was found to be similar in the frontal cortex, caudate-putamen, nucleus accumbens, lateral and medial septum, the density of [3H]muscimol binding was lower in cingulate cortex of alcohol low-preferring rats as compared to alcohol high preferring rats. Moreover, the density of muscimol binding sites within this area was positively correlated with the intensity of ethanol consumption.
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Dyr
authors.forename: M
authors.initials: M
authors.lastname: Siemiatkowski
authors.forename: A
authors.initials: A
authors.lastname: Płaźnik
authors.forename: A
authors.initials: A
authors.lastname: Bidziński
authors.forename: W
authors.initials: W
authors.lastname: Kostowski
mesh_terms: D000428:Alcohol Drinking / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D018755:GABA Agonists / Q000378:metabolism*; D058785:GABA-A Receptor Agonists; D009118:Muscimol / Q000378:metabolism*; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D012641:Selection, Genetic
chemical_list: D018755:GABA Agonists; D058785:GABA-A Receptor Agonists; D011963:Receptors, GABA-A; D009118:Muscimol; D000431:Ethanol