Interference of eukaryotic signalling pathways by the bacteria Yersinia outer protein YopJ.
Upon contact with bacteria, eukaryotic cells activates a slurry of defence mechanisms via distinct signalling transduction pathways. However, some bacteria have evolved strategies to escape or inhibit these host defence systems. We have recently shown that the bacteria Yersinia pseudotuberculosis, which encodes the Yersinia outer protein (YopJ) appears to inhibit the activation of NF-kappaB by preventing the phosphorylation of IkappaB. In a subsequent series of experiments it has also been shown that YopJ blocks the phosphorylation of the p38 MAP kinase. Here the regulatory function of YopJ on eukaryotic signal transduction is discussed.
Spiik
A K
AK
Center for Genomics Research, Karolinska Institute, Stockholm, Sweden. ann-kristin.spiik@cgr.ki.se
Meijer
L K
LK
Ridderstad
A
A
Pettersson
S
S
D001426:Bacterial Proteins / Q000494:pharmacology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology*; D020928:Mitogen-Activated Protein Kinases; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D010766:Phosphorylation / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D015011:Yersinia pseudotuberculosis / Q000472:pathogenicity*; D048051:p38 Mitogen-Activated Protein Kinases
D001426:Bacterial Proteins; D017362:Cyclic AMP Response Element-Binding Protein; D016328:NF-kappa B; C109227:YopP protein, Yersinia; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases