Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonism.
Lewy body (LB) is consistently found in the substantia nigra in Parkinson's disease. We report a 68-year-old woman with late-onset, dopa-responsive parkinsonism. Her parents were first cousins, but no other affected individuals were present in the family. Autopsy revealed moderate loss of pigmented neurons with gliosis, but neither LBs nor neurofibrillary tangles in the substantia nigra. The locus ceruleus showed neuronal loss with scarce LBs. The most striking change was found in the dorsal vagal nucleus, where marked neuronal loss and fibrillary gliosis with many LBs were evident. Despite the use of ubiquitin and alpha-synuclein immunohistochemistry, no further LBs were identified in other brain regions. These findings suggest that this case was an unusual, anatomically restricted manifestation of LB disease.
Wakabayashi
K
K
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan. koichi@bri.niigata-u.ac.jp
Toyoshima
Y
Y
Awamori
K
K
Anezaki
T
T
Yoshimoto
M
M
Tsuji
S
S
Takahashi
H
H
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D016631:Lewy Bodies / Q000473:pathology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology; D014630:Vagus Nerve / Q000473:pathology*
D000978:Antiparkinson Agents; D007980:Levodopa