title: [Effects of abnormal distribution of calcium on impairment of myocardial mechanics in the early stage of thermal injury].
abstract: OBJECTIVE
  To investigate the effect of abnormal Ca2+ distribution on impairment of myocardial mechanics in the early stage of thermal injury.
  
  
  METHODS
  Calcium (Ca2+) changes were observed within subcellular distribution in situ in rat heart with calcium cytochemical probe and electron probe microanalysic technique. Meanwhile, myocardial mechanics and energy metabolic changes were investigated after thermal injury.
  
  
  RESULTS
  The results demonstrated that levels of cytoplasmic Ca2+ in cardiomyocytes increased at 1 hour, followed by enhanced mitochondrial Ca2+ at 3 hour after burn injury. Parallel to the changes in Ca2+, there were decrease of myocardial contraction, relaxation capacity and increase of ventricular wall stiffness in burned rats. A lower level of heart energy changes was observed from 6 to 12 hours, compared with control group.
  
  
  CONCLUSIONS
  The results indicate that subcellular Ca2+ abnormal distribution in myocardium caused by burn injury may be associated with rigor contraction and decreased relaxation of myocardium.
authors.affiliation: Southwest Hospital, 3rd Military Medical University, Chongqing.
authors.forename: L
authors.initials: L
authors.lastname: Chi
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Huan
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002118:Calcium