Little benefit from mild hypothermia therapy for severely head injured patients with low intracranial pressure.
OBJECTIVE
This study was performed to determine whether mild hypothermia therapy is essential for the treatment of severely head injured patients in whom intracranial pressure (ICP) can be maintained below 20 mm Hg by using conventional therapies.


METHODS
Sixteen consecutive severely head injured patients fulfilled the following criteria: the patient's ICP was maintained below 20 mm Hg by using fluid restriction, hyperventilation, and high-dose barbiturate therapy; and the patient had a Glasgow Coma Scale score of 8 or less on admission. After conventional therapies had been applied, the patients were divided randomly into two groups: the mild hypothermia group (HT group; eight patients) and the normothermia group (NT group; eight patients). The HT group received mild hypothermia (intracranial temperature 34 degrees C) therapy for 48 hours followed by rewarming at 1 degree C per day for 3 days, whereas the NT group received normothermia (intracranial temperature 37 degrees C) therapy for 5 days. Specimens of cerebrospinal fluid (CSF) taken from an intraventricular catheter every 24 hours were analyzed for the presence of excitatory amino acids ([EAAs] glutamate, aspartate, and glycine) and cytokines (tumor necrosis factor-alpha, interleukin [IL]-1beta, IL-6, IL-8, and IL-10). The two groups did not differ significantly in patient age, neurological status, or level of ICP. There were no significant differences in daily changes in CSF concentrations of EAAs and cytokines between the two groups. The incidence of pneumonia was slightly higher in the HT group compared with the NT group (p = 0.059). The incidence of diabetes insipidus associated with hypernatremia was significantly higher in the HT group compared with that in the NT group (p < 0.01). The two groups did not differ with respect to their clinical outcomes.


CONCLUSIONS
The authors recommend normothermia therapy for the treatment of severely head injured patients in whom ICP can be maintained at lower than 20 mm Hg by using conventional therapies, because mild hypothermia therapy does not convey any advantage over normothermia therapy in such patients.
Shiozaki
T
T
Department of Traumatology, Osaka University Medical School, Japan.
Kato
A
A
Taneda
M
M
Hayakata
T
T
Hashiguchi
N
N
Tanaka
H
H
Shimazu
T
T
Sugimoto
H
H
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001831:Body Temperature / Q000502:physiology; D002648:Child; D006259:Craniocerebral Trauma / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000628:therapy*; D003919:Diabetes Insipidus / Q000209:etiology; D018846:Excitatory Amino Acids / Q000134:cerebrospinal fluid; D005260:Female; D005440:Fluid Therapy; D015600:Glasgow Coma Scale; D006801:Humans; D006955:Hypernatremia / Q000209:etiology; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007036:Hypothermia, Induced / Q000379:methods*; D007378:Interleukins / Q000134:cerebrospinal fluid; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011014:Pneumonia / Q000209:etiology; D012121:Respiration, Artificial; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
D018846:Excitatory Amino Acids; D006993:Hypnotics and Sedatives; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha