Surgical resection for cancer of the cardia.
From the pathogenic and therapeutic point of view, adenocarcinomas of the esophagogastric junction (AEG) should be classified into adenocarcinoma of the distal esophagus (Type I), true carcinoma of the cardia (Type II), and subcardial carcinoma (Type III). This classification can be easily performed by summarizing the information available from contrast radiography, endoscopy, and intra-operative findings; it allows comparison of data between various centers and facilitates the choice of surgical therapy. A complete removal of the primary tumor and its lymphatic drainage has to be the primary goal of any surgical approach to adenocarcinoma of the esophagogastric junction. In patients with potentially resectable, true carcinoma of the cardia (AEG Type II), this can be achieved by a total gastrectomy with transhiatal resection of the distal esophagus and en bloc removal of the lymphatic drainage in the lower posterior mediastinum and along the celiac axis and superior border of the pancreas. This approach is associated with lower morbidity and provides equal long-term survival as compared to the more radical transmediastinal or abdominothoracic esophagogastrectomy. Whether a routine splenectomy for lymphadenectomy in the splenic hilus offers a survival benefit in these patients is questionable. In patients with early tumors staged as uT1 on pre-operative endosonography, a limited resection of the proximal stomach, cardia, and distal esophagus with interposition of a pedicled isoperistaltic jejunal segment appears justified since this procedure allows a complete tumor removal with adequate lymphadenctomy and offers excellent functional results. Multimodal therapy with pre-operative polychemotherapy or combined radio-chemotherapy appears to offer a significant survival benefit in patients with locally advanced tumors. With this tailored approach, extensive pre-operative staging becomes mandatory for an adequate selection of the appropriate therapeutic concept.
Siewert
J R
JR
Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
Stein
H J
HJ
Sendler
A
A
Fink
U
U
D000230:Adenocarcinoma / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D002299:Cardia; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000000981:diagnostic imaging / Q000473:pathology; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D007583:Jejunum / Q000637:transplantation; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011859:Radiography; D013156:Splenectomy; D013274:Stomach Neoplasms / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D015996:Survival Rate