title: Hospitalization for 5-FU toxicity in metastatic colorectal cancer: incidence and cost.
abstract: Although treatment with 5-fluorouracil (5-FU) plus calcium folinate has been reported to prolong survival in patients with metastatic colorectal cancer, it can also cause significant toxicity, potentially, resulting in hospitalization. The incidence and cost of these admissions have not been fully documented. The purpose of this study was to document the incidence and cost of toxicity-related admissions among patients with newly diagnosed metastatic colorectal cancer who received 5-FU.
authors.affiliation: Policy Analysis Inc. (PAI), Brookline, MA 02445, USA.
authors.forename: G
authors.initials: G
authors.lastname: Oster
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D017281:Cost of Illness; D004342:Drug Hypersensitivity / Q000191:economics / Q000209:etiology* / Q000628:therapy; D005472:Fluorouracil / Q000009:adverse effects*; D017721:Hospital Costs; D006760:Hospitalization / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D012189:Retrospective Studies
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil