title: Interferon beta treatment for multiple sclerosis has a graduated effect on MRI enhancing lesions according to their size and pathology.
abstract: OBJECTIVE
  The ability of recombinant human interferon beta-1a (rh-IFN beta-1a) to suppress multiple sclerosis activity, evaluated from MRI, was assessed across a range of lesions enhancing at different gadolinium-DTPA (Gd) doses and with different sizes.
  
  
  METHODS
  Every 4 weeks, standard dose (Sd; 0.1 mmol/kg Gd) and triple dose (Td; 0.3 mmol/kgGd) MRI were obtained from 18 patients with relapsing-remitting multiple sclerosis for 3 months before and 4 months after starting treatment with 44 microgram rh-IFN beta-1a subcutaneously, once a week.
  
  
  RESULTS
  The total numbers of enhancing lesions were 145 and 126 on Sd scans and 278 and 192 on the Td scans obtained before and after treatment. The introduction of treatment decreased, on average, the rate of appearance of new enhancing lesions seen on Sd and Td scans by 37% (p<0.001). Treatment effects on new enhancing lesions seen on Td scans was, on average, 28% higher than on those seen on Sd scans. The distribution of lesion sizes on Td scans changed significantly during the treatment period (p=0.05), due to a marked decrease in the number of small lesions.
  
  
  CONCLUSIONS
  The effect of 44 microgram rh-IFN beta-1a in reducing multiple sclerosis disease activity, as monitored by Gd enhanced MRI, is not homogeneous, but graduated according to the pathological characteristics and size of the lesions.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Filippi
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.forename: R
authors.initials: R
authors.lastname: Capra
authors.forename: C
authors.initials: C
authors.lastname: Gasperini
authors.forename: F
authors.initials: F
authors.lastname: Prandini
authors.forename: V
authors.initials: V
authors.lastname: Martinelli
authors.forename: M A
authors.initials: MA
authors.lastname: Horsfield
authors.forename: S
authors.initials: S
authors.lastname: Bastianello
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: C
authors.initials: C
authors.lastname: Pozzilli
authors.forename: G
authors.initials: G
authors.lastname: Comi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology* / Q000628:therapy*
chemical_list: D016899:Interferon-beta