title: Evaluation of the effects of desmopressin in acute ureteral obstruction.
abstract: OBJECTIVE
  To evaluate the effects of desmopressin on pressure values inside the pelvis and ureter of the rat following acute obstruction.
  
  
  METHODS
  By means of a microsurgical technique, 24 male Wistar rats were submitted to ureteral obstruction; pressure inside the ureter was recorded using a cannula and a micrometric glass column. In the treatment group (14 animals) 6 mg/kg of desmopressin were administered 30 min before the beginning of the experiment.
  
  
  RESULTS
  Rats pretreated with desmopressin showed a statistically significant reduction in mean intraureteral pressure following acute obstruction (p = 0.05).
  
  
  CONCLUSIONS
  In Wistar rats desmopressin demonstrated a powerful antidiuretic effect, reducing the intraureteral pressure. The experimental model is useful for a better understanding of physiopathology of renal colic and acute obstruction.
authors.affiliation: Department of Urology, Udine University, Udine, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Moro
authors.forename: S
authors.initials: S
authors.lastname: De Stefani
authors.forename: A
authors.initials: A
authors.lastname: Crisci
authors.forename: P
authors.initials: P
authors.lastname: De Antoni
authors.forename: C A
authors.initials: CA
authors.lastname: Scott
authors.forename: C
authors.initials: C
authors.lastname: Selli
mesh_terms: D000208:Acute Disease; D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D004195:Disease Models, Animal; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010388:Pelvis / Q000503:physiopathology; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D012076:Renal Agents / Q000494:pharmacology*; D015203:Reproducibility of Results; D014513:Ureter / Q000187:drug effects* / Q000503:physiopathology; D014517:Ureteral Obstruction / Q000503:physiopathology*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin