A new series of mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase from beef liver.
Nucleosides I, II, III caused irreversible inactivation of AdoHcy hydrolase. A mechanism of inactivation is proposed.
Vandenplas
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C
UMR 6519 CNRS-UFR Sciences de Reims, France.
Guillerm
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D
Guillerm
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G
D043383:Adenosylhomocysteinase; D000818:Animals; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology*
D004791:Enzyme Inhibitors; D006867:Hydrolases; D043383:Adenosylhomocysteinase