Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists.
The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripeptide sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.
Xu
T L
TL
Institute of Radiation Medicine, Beijing, PR, China.
Jiang
X T
XT
Hua
W Y
WY
Ni
P Z
PZ
Pei
Y M
YM
D000244:Adenosine Diphosphate / Q000494:pharmacology; D015195:Drug Design; D020128:Inhibitory Concentration 50; D009842:Oligopeptides / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D014443:Tyrosine / Q000737:chemistry*
D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014443:Tyrosine; D000244:Adenosine Diphosphate; C047981:arginyl-glycyl-aspartic acid