Antibacterial and cytotoxic natural and synthesized hydroquinones from sponge Ircinia spinosula.
In order to check the structure-activity relationship and find more potent derivatives of the natural products 1 and 2 obtained from sponge Ircinia spinosula, a series of oxidation, hydrogenation, acetylation and methylation derivatives was prepared. All compounds (natural and synthetic ones) were screened for their cytotoxic and antibacterial activities. The biological studies showed a wide range of antibacterial activity even though only 2 and 2d showed a moderate cytotoxicity against the clone C98. The oxidation of the hydroquinone to quinone and the hydrogenation of the side-chain increased the antibacterial effect of the molecules.
Mihopoulos
N
N
Department of Pharmacognosy, University of Athens, Greece.
Vagias
C
C
Chinou
I
I
Roussakis
C
C
Scoullos
M
M
Harvala
C
C
Roussis
V
V
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D002289:Carcinoma, Non-Small-Cell Lung; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008175:Lung Neoplasms; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D006873:Hydroquinones