title: A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.
abstract: A P157S mutation in the reverse transcriptase (RT) of human immunodeficiency virus type 1 conferred fivefold resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine in cell culture. Interestingly, the P157S mutation resulted in increased sensitivity (two- to threefold) to 3'-azido-3'-deoxythymidine (AZT) and to (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA). A similar increase in susceptibility to AZT and to PMPA was also conferred by the M184V mutation in RT.
authors.affiliation: Eccles Institute of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Smith
authors.forename: G J
authors.initials: GJ
authors.lastname: Klarmann
authors.forename: K M
authors.initials: KM
authors.lastname: Stray
authors.forename: U K
authors.initials: UK
authors.lastname: von Schwedler
authors.forename: R F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: B D
authors.initials: BD
authors.lastname: Preston
authors.forename: T W
authors.initials: TW
authors.lastname: North
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000302:isolation & purification; D015497:HIV-1 / Q000235:genetics / Q000472:pathogenicity; D006367:HeLa Cells; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology*; D017354:Point Mutation; D011392:Proline / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D012694:Serine / Q000235:genetics
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D012694:Serine; D011392:Proline; D054303:HIV Reverse Transcriptase