Membrane association with multiple calcium ions: vitamin-K-dependent proteins, annexins and pentraxins.
Peripheral membrane association with high calcium stoichiometry is shared by three families of proteins: annexins, pentraxins and vitamin-K-dependent proteins. Recent crystal structure determinations, biophysical studies of membrane binding and analyses of protein electrostatic properties offer striking and different concepts for membrane association by each of these protein families.
Nelsestuen
G L
GL
Department of Biochemistry, Molecular Biology and Biophysics University of Minnesota, St Paul, MN 55108, USA. nelse002@maroon.tc.umn.edu
Ostrowski
B G
BG
D015055:1-Carboxyglutamic Acid / Q000378:metabolism; D000510:Alpha-Globulins / Q000737:chemistry / Q000378:metabolism*; D019943:Amino Acid Substitution; D017302:Annexins / Q000378:metabolism*; D001665:Binding Sites; D002097:C-Reactive Protein / Q000737:chemistry / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016384:Consensus Sequence; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D011485:Protein Binding; D011487:Protein Conformation; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D000683:Serum Amyloid P-Component / Q000737:chemistry / Q000378:metabolism*; D055672:Static Electricity; D014812:Vitamin K / Q000378:metabolism*
D000510:Alpha-Globulins; D017302:Annexins; D008563:Membrane Lipids; D000683:Serum Amyloid P-Component; C030974:female protein, hamster; D014812:Vitamin K; D015055:1-Carboxyglutamic Acid; D002097:C-Reactive Protein; D008239:Lysine; D002118:Calcium