title: Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention.
abstract: Physiological stress is known to produce analgesia and memory disruption. Brain renin angiotensin system (RAS) has been reported to participate in stress response and plays a role in the processing of sensory information. Angiotensin receptors (AT), particularly AT1 subtypes have been reported to be distributed in brain areas that are intimately associated with stress response. The purpose of present study was to examine the modulation of AT1 receptor in the immobilization stress and angiotensin II (AngII)-induced analgesia and impaired retention, and to determine whether resultant behavioral changes involve common sensory signals. Result of present experiments showed that immobilization stress in mice and rats, and intracerebroventricular (ICV) administration of AngII (10 and 20 ng) in rats produced an increase in tail-flick latency. Similarly, post training administration of AngII or immobilization stress produced impairment of retention tested on plus-maze learning and on passive avoidance step-down task. Both these responses were sensitive to reversal by prior treatment with losartan (10 and 20 mg/kg), an AT1 AngII receptor antagonist. On the other hand, naloxone, an opiate antagonist preferentially attenuated the stress and AngII-induced analgesia and retention deficit induced by immobilization stress, but failed to reverse the AngII induced retention deficit. These results suggest immobilization stress-induced analgesia and impaired retention involves the participation of brain RAS. Further, failure of naloxone to reverse AngII-induced retention impairment shows. AngII-induced behavioral changes are under control of different sensory inputs.
authors.affiliation: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
authors.forename: V
authors.initials: V
authors.lastname: Raghavendra
authors.forename: K
authors.initials: K
authors.lastname: Chopra
authors.forename: S K
authors.initials: SK
authors.lastname: Kulkarni
mesh_terms: D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051379:Mice; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D011945:Receptors, Angiotensin; D000804:Angiotensin II