title: Effective treatment with chemotherapy and surgical resection for small cell carcinoma of the esophagus: report of a case.
abstract: We report on a patient with small cell carcinoma of the esophagus treated with effective combination chemotherapy followed by surgical resection. A 69 year-old male had an ulcerated tumor in the middle part of the esophagus, which was microscopically diagnosed as small cell carcinoma of the esophagus. After combination chemotherapy, endoscopy showed that the esophageal tumor had changed into a shallow ulcer. No cancer cell was found in the biopsy specimen of the ulcer. A subtotal esophagectomy with regional lymph node dissection was performed. Histological examination showed that a few cancer cells remained in a microvessel of the submucosal layer in the removed esophagus and no cancerous lesion was found in regional lymph nodes. The patient was well and was able to remain at home. However, he eventually died 21 months after first detection of the carcinoma due to progression of multiple lung and mediastinal lymph node metastases. After complete or partial remission is achieved by the combination chemotherapy, surgical resection may be recommended as the second therapy that occasionally produces long-term remission and possibly long-term survival for patients with small cell carcinoma of the esophagus, such as the present case.
authors.affiliation: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. ynimura@hsp.md.shinshu-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
authors.forename: N
authors.initials: N
authors.lastname: Koide
authors.forename: A
authors.initials: A
authors.lastname: Nishio
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: W
authors.initials: W
authors.lastname: Adachi
authors.forename: S
authors.initials: S
authors.lastname: Koike
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: J
authors.initials: J
authors.lastname: Amano
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy; D004947:Esophagus / Q000473:pathology; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008297:Male