Localization of immunoreactive testosterone and 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in cynomolgus monkey (Macaca fascicularis) testes during postnatal development.
The age-related expression of testosterone and 3beta-HSD in the testes of cynomolgus monkeys was detected using light-microscopic immunocytochemistry. Intense deposits of immunoreactive testosterone were labeled in parts of Leydig cells in neonatal, late infantile, pubertal, and adult testes, and only a few Leydig cells in early infantile testes. The immunoreactive 3beta-HSD was labeled in parts of Leydig cells and in all Sertoli cells in neonatal, late infantile, pubertal, and adult testes, whereas only a few Leydig cells, but no Sertoli cells, were labeled in early infantile testes. The fluctuations of testosterone and 3beta-HSD expression in testes correlated well with those already observed plasma testosterone levels during postnatal development in cynomolgus monkeys.
Liang
J H
JH
Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan.
Sankai
T
T
Yoshida
T
T
Cho
F
F
Yoshikawa
Y
Y
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000378:metabolism; D008252:Macaca fascicularis / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism; D013737:Testis / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D015096:3-Hydroxysteroid Dehydrogenases