Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells.
We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
Slominski
A
A
Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. aslomin@wpo.it.luc.edu
Gomez-Sanchez
C E
CE
Foecking
M F
MF
Wortsman
J
J
D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis; D000804:Angiotensin II / Q000494:pharmacology; D003345:Corticosterone / Q000096:biosynthesis*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D006801:Humans; D007700:Kinetics; D008545:Melanoma / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000804:Angiotensin II; C042509:18-hydroxydeoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone