title: A cytotoxic triterpene saponin from the root bark of Aralia dasyphylla.
abstract: A novel triterpene saponin (1) was isolated from an ethanol extract of the root bark of Aralia dasyphylla. Its structure was elucidated as 3-O-[beta-D-glucopyranosyl (1-->3)-beta-D-galactopyranosyl(1-->2)]-beta-D-glucuronopyranosyl- ole anolic acid-28-O-beta-D-glucopyranoside, according to spectral and chemical evidence. Compound 1 showed significant cytotoxic activity against KB and Hela-S(3) cells.
authors.affiliation: School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China. Frank_toris@kali.com.cn
authors.forename: K
authors.initials: K
authors.lastname: Xiao
authors.forename: Y H
authors.initials: YH
authors.lastname: Yi
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Wang
authors.forename: H F
authors.initials: HF
authors.lastname: Tang
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Li
authors.forename: H W
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D006868:Hydrolysis; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D019441:Plant Epidermis / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
chemical_list: C121597:3-O-(glucopyranosyl-1-3-galactopyranosyl)-1-2-glucuronopyranosyl-oleanolic acid-28-O-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D009828:Oleanolic Acid