Effects of saiboku-to on dual-phase bronchoconstriction in asthmatic guinea pigs.
In recent years, bronchial asthma has come to be regarded pathologically as a chronic inflammatory disease of the respiratory tract. Inhalational steroids and antiinflammatory drugs are recognized as being effective against bronchial asthma. In this study, the effects of Saiboku-to, a Chinese herbal (Kampo) formulation, were investigated on asthmatic guinea pigs sensitized to ovalbumin (OA). Following 7-day administration of Saiboku-to (500 micrograms/kg), the late asthmatic response (LAR) to an antigen challenge was found to be inhibited. The number of eosinophils in fluid obtained by bronchoalveolar lavage (BAL) 4 h after antigen challenge was decreased while the infiltration of eosinophils and T-lymphocytes into the lung parenchyma was inhibited. These findings suggest that Saiboku-to has the potential to become a useful drug in the treatment of bronchial asthma.
Tohda
Y
Y
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Haraguchi
R
R
Kubo
H
H
Muraki
M
M
Fukuoka
M
M
Nakajima
S
S
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D016084:Bronchoconstriction / Q000187:drug effects* / Q000276:immunology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D008516:Medicine, Chinese Traditional; D010047:Ovalbumin / Q000008:administration & dosage
D000941:Antigens; D001993:Bronchodilator Agents; D004365:Drugs, Chinese Herbal; D010047:Ovalbumin