Correlation of vasomotor- and respiratory-controlling mechanisms around the caudal ventrolateral medulla in cats.
We examined the involvement of caudal ventrolateral medulla (CVLM) in respiratory control. Microinjection of glutamate (Glu) into CVLM decreased systemic arterial blood pressure (SAP) and altered phrenic nerve activities (PNA). Among 143 depressor sites, 55% (78/143) increased respiratory frequency (Rf), while 72% altered PNA amplitude (36% increased and 36% decreased). A small but significant positive correlation was observed between the magnitudes of depressor responses and inhibition of PNA amplitude (r = 0.1718, n = 143), indicating a substantial cross-talk between depressor and PNA inhibitory neurons. Furthermore, microinjections of acetylcholine (ACh) mimicked the Glu-induced depressor responses. However, ACh did not alter Rf, but still reduced PNA amplitude. Our findings suggest that Rf-regulating and depressor neurons are two separate neuronal populations, coexisting in CVLM. The PNA inhibitory and depressor neurons, in contrast, could have stronger correlation.
Yang
K T
KT
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC.
Su
C K
CK
Chai
C Y
CY
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002415:Cats; D018698:Glutamic Acid / Q000008:administration & dosage / Q000494:pharmacology; D008526:Medulla Oblongata / Q000502:physiology*; D008845:Microinjections; D010791:Phrenic Nerve / Q000187:drug effects / Q000502:physiology; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D014666:Vasomotor System / Q000502:physiology*
D018698:Glutamic Acid; D000109:Acetylcholine