title: Synthesis and antiviral activity of L-2'-deoxy-2'-up-fluoro-4'-thionucleosides.
abstract: L-2'-Deoxy-2'-up-fluoro-4'-thionucleosides were efficiently synthesized from D-xylose via L-4-thioarabitol derivative as a key intermediate and evaluated for antiviral activities against HIV-1, HSV-1,2 and HBV.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: L S
authors.initials: LS
authors.lastname: Jeong
authors.forename: H R
authors.initials: HR
authors.lastname: Moon
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoo
authors.forename: S N
authors.initials: SN
authors.lastname: Lee
authors.forename: H D
authors.initials: HD
authors.lastname: Kim
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D013872:Thionucleosides