An alternative synthesis of [11C]raclopride for routine use.
The standard method of [11C]raclopride synthesis requires a large amount of its desmethyl precursor. We prepared [11C]raclopride by methylation of a small amount of desmethyl derivative (0.3-0.5 mg) with [11C]methyl iodide in a DMF solution containing NaH, with a decay-corrected radiochemical yield of 11-14% based on [11C]methyl iodide and with a specific activity of 48 TBq/mmol for 25 min from EOB. The reaction was reproducible and reliable.
Ishiwata
K
K
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan. ishiwata@pet.tmig.or.jp
Ishii
S
S
Senda
M
M
D018492:Dopamine Antagonists / Q000138:chemical synthesis*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D008745:Methylation; D020891:Raclopride; D011869:Radioligand Assay; D012457:Salicylamides / Q000138:chemical synthesis*
D018492:Dopamine Antagonists; D008024:Ligands; D012457:Salicylamides; D020891:Raclopride