Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa.
p-Methoxy benzoic acid isolated from the methanolic soluble fraction of the aqueous extract of Capparis spinosa L. (Capparidaceae) was found to possess significant antihepatotoxic activity against carbontetrachloride and paracetamol induced hepatotoxicity in vivo and thioacetamide and galactosamine induced hepatotoxicity in isolated rat hepatocytes, using in vitro technique. The compound was characterized through physicochemical and spectral studies. Isolation, identification and antihepatotoxic activity of the compound is reported for the first time in the plant. HPTLC analysis of methanol soluble fraction indicated that the compound constitutes 33% w/w of the active fraction.
Gadgoli
C
C
Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, Gujarat, India.
Mishra
S H
SH
D000818:Animals; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D002855:Chromatography, Thin Layer; D005260:Female; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000302:isolation & purification / Q000627:therapeutic use*; D007194:India; D008111:Liver Function Tests; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D010936:Plant Extracts; C004520:4-anisic acid