title: [Anti-hyperlipidemic drug].
abstract: Drug treatment of hyperlipidemia was reviewed. In the first part, mode of action, efficacy and safety of lipid-lowering agents were described and in the second part, strategies for treatment of hyperlipidemia was described. Treatment of hypercholesterolemia should be started with statin and if the reduction is not enough, cholestimide or nicotinic acid or probucol can be added. Mild hypertriglyceridemia can be treated with dextran sulfate sodium, but usually low dose of fenofibrate or bezafibrate will be necessary. For severe cases, combination therapy with fibrate and nicotinic acid or ethyl icosapentate is required. Treatment of combined hyperlipidemia should be started with fibrate, but when the increment of cholesterol is superior to triglyceride, statin can be chosen. If these drugs are not fully effective, combination therapy with statin and ethyl icosapentate is recommended.
authors.affiliation: Tokyo Metropolitan National Health Insurance Organization, Fussa Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Nakaya
mesh_terms: D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D013927:Thrombosis / Q000188:drug therapy*
chemical_list: D000960:Hypolipidemic Agents