Lack of protective effects of dietary silicon on aluminium-induced maternal and developmental toxicity in mice.
In recent years, it has been demonstrated that oral aluminium (Al) exposure can produce growth retardation, delayed ossification and an increased incidence of foetal abnormalities in rats and mice. On the other hand, it has been also suggested that silicon may have a protective effect in limiting oral Al absorption. The aim of the present study was to assess whether dietary silicon could prevent against Al-induced maternal and developmental toxicity in mice. On gestation days 6-15, Al nitrate nonahydrate (398 mg/kg/day) was given by gavage to three groups of pregnant animals, which also received silicon in drinking water at concentrations of 0, 118 and 236 mg/l on days 7-18 of gestation. Three additional groups of pregnant mice received respectively: 270.6 mg/kg of sodium nitrate (gavage), and silicon in drinking water at 118 and 236 mg/l. Although silicon administration at 236 mg/l significantly reduced the percentage of Al-induced deaths, abortions and early deliveries, neither 118 nor 236 mg/l of silicon produced significant ameliorations on Al-induced foetotoxicity. Under the current experimental conditions dietary silicon was not effective in protecting against Al-induced developmental toxicity.
Bellés
M
M
Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, San Lorenzo, Reus, Spain.
Albina
M L
ML
Sánchez
D J
DJ
Domingo
J L
JL
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000196:embryology; D004032:Diet; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009566:Nitrates / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012744:Sex Ratio; D012825:Silicon / Q000008:administration & dosage / Q000494:pharmacology*; D015996:Survival Rate
D017607:Aluminum Compounds; D009566:Nitrates; C050609:aluminum nitrate; D012825:Silicon