Effect of antibiotics and anti-inflammatory agents on the purified protein derivative response in the rat.
We investigated the effects of several antibiotics and anti-inflammatory agents on the purified protein derivative (PPD) response in the rat. Animals were immunized with Mycobacterium bovis vaccine BCG. Antibiotics and anti-inflammatory drugs were administered at therapeutic doses for 10 d. Chloramphenicol, erythromycin, aspirin and ibuprofen suppressed the PPD response, but penicillin and acetaminophen had no significant effects.
Kabakuş
N
N
Department of Pediatrics, Faculty of Medicine, Firat University, Elazig, Turkey.
Kalkan
A
A
Felek
S
S
Yilmaz
B
B
Mogulkoç
R
R
Baltaci
A
A
Kiliç
S S
SS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001500:BCG Vaccine / Q000008:administration & dosage; D005188:False Negative Reactions; D005260:Female; D007114:Immunization; D051381:Rats; D017208:Rats, Wistar; D014373:Tuberculin / Q000276:immunology*; D014374:Tuberculin Test
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001500:BCG Vaccine; D014373:Tuberculin