Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes.
Gram-negative bacterial lipopolysaccharide evokes a protective inflammatory response in the normal host. Through genetic analysis of mutant mice, the gene encoding Toll-like receptor 4 (Tlr4) was recently identified as a critical component of this host defense mechanism. Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals.
Qureshi
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Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6. cxqu@musica.mcgill.ca
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D000818:Animals; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D008070:Lipopolysaccharides / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D005810:Multigene Family; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000502:physiology; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors