Effects of acute intraperitoneal administration of tetrazepam on blood glucose level and serum lipids in hyperlipidemic albino rats.
In rats rendered hyperlipidemic by the i.p. injection of Triton WR-1339, the i.p. administration of tetrazepam, a benzodiazepine (BZD) used mainly as a central myorelaxant, evoked significant reductions of serum lipids and blood glucose level. The dose-response curve was bell-shaped for serum lipids changes, whereas no clear dose-response relationship for blood glucose level modifications could be established. Tetrazepam was less active on serum lipids than other BZDs as diazepam or midazolam.
Horák
J
J
Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Horák
A
A
Cuparencu
B
B
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001569:Benzodiazepines; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D011345:Fenofibrate / Q000494:pharmacology; D006949:Hyperlipidemias / Q000097:blood*; D007274:Injections, Intraperitoneal; D008055:Lipids / Q000097:blood*; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D014151:Anti-Anxiety Agents; D001786:Blood Glucose; D008055:Lipids; D009125:Muscle Relaxants, Central; D014280:Triglycerides; D001569:Benzodiazepines; D002784:Cholesterol; C005245:tetrazepam; D003975:Diazepam; D011345:Fenofibrate