Inhibition of cathepsin D by tripeptides containing statine analogs.
Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.
Bessodes
M
M
CNRS UMR 133, ENSCP, Paris, France. bessodes@infobiogen.fr
Antonakis
K
K
Herscovici
J
J
Garcia
M
M
Rochefort
H
H
Capony
F
F
Lelièvre
Y
Y
Scherman
D
D
D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D002402:Cathepsin D / Q000037:antagonists & inhibitors*; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010436:Pepstatins / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000596:Amino Acids; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D010436:Pepstatins; D011480:Protease Inhibitors; C014195:Streptomyces pepsin inhibitor; D002402:Cathepsin D; C031375:pepstatin; C013165:statine