title: Effects of cycloSal-d4TMP derivatives in H9 cells with induced AZT resistance phenotype.
abstract: Cytotoxic and antiretroviral activity of cycloSal-d4TMP derivatives were tested in a new AZT-resistant H9 cell subline (H9rAZT250). The results showed, that cycloSal-d4TMP derivatives overcame resistance of HIV-1 to d4T in H9rAZT250 cells, which exert decreased thymidine kinase (TK) gene expression.
authors.affiliation: Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., Germany.
authors.forename: B
authors.initials: B
authors.lastname: Gröschel
authors.forename: C
authors.initials: C
authors.lastname: Meier
authors.forename: R
authors.initials: R
authors.lastname: Zehner
authors.forename: J
authors.initials: J
authors.lastname: Cinatl
authors.forename: H W
authors.initials: HW
authors.lastname: Doerr
authors.forename: J
authors.initials: J
authors.lastname: Cinatl
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D004352:Drug Resistance, Microbial; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018119:Stavudine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013937:Thymidine Kinase / Q000235:genetics; D015215:Zidovudine / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D017931:DNA Primers; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D018119:Stavudine; D013937:Thymidine Kinase