Pax7 is expressed in the capsules surrounding adult mouse neuromuscular spindles.
The multigene Pax family of transcription factors plays an important role in the development of the central nervous system as well as in organ morphogenesis. Expression of one of the members of the family, Pax7, has been described in embryonic muscle and in both embryonic and adult brain. We recently detected Pax7 transcripts in RNA isolated from adult mouse skeletal muscle and brain and here use in situ hybridisation to localise the expression within these tissues. Pax7 expression was observed in neural cells of the brain and in cells of neural crest origin in the inner and outer capsules of neuromuscular spindles. The results suggest that Pax7 may be implicated in the formation and maintenance of neuromuscular contacts within the muscle spindle throughout life.
Rodger
J
J
Department of Zoology, The University of Western Australia, Nedlands, Perth, Australia. jrodger@cyllene.uwa.edu.au
Ziman
M R
MR
Papadimitriou
J M
JM
Kay
P H
PH
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D018398:Homeodomain Proteins; D008099:Liver / Q000378:metabolism / Q000469:parasitology; D008297:Male; D051379:Mice; D009124:Muscle Proteins / Q000235:genetics*; D009470:Muscle Spindles / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051763:PAX7 Transcription Factor
D018398:Homeodomain Proteins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D051763:PAX7 Transcription Factor; C497322:Pax7 protein, mouse