title: Localization of immunoreactive testosterone and 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in cynomolgus monkey (Macaca fascicularis) testes during postnatal development.
abstract: The age-related expression of testosterone and 3beta-HSD in the testes of cynomolgus monkeys was detected using light-microscopic immunocytochemistry. Intense deposits of immunoreactive testosterone were labeled in parts of Leydig cells in neonatal, late infantile, pubertal, and adult testes, and only a few Leydig cells in early infantile testes. The immunoreactive 3beta-HSD was labeled in parts of Leydig cells and in all Sertoli cells in neonatal, late infantile, pubertal, and adult testes, whereas only a few Leydig cells, but no Sertoli cells, were labeled in early infantile testes. The fluctuations of testosterone and 3beta-HSD expression in testes correlated well with those already observed plasma testosterone levels during postnatal development in cynomolgus monkeys.
authors.affiliation: Tsukuba Primate Center, National Institute of Infectious Diseases, Ibaraki, Japan.
authors.forename: J H
authors.initials: JH
authors.lastname: Liang
authors.forename: T
authors.initials: T
authors.lastname: Sankai
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: F
authors.initials: F
authors.lastname: Cho
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000378:metabolism; D008252:Macaca fascicularis / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism; D013737:Testis / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D015096:3-Hydroxysteroid Dehydrogenases