[A multicompartmental and multifactorial model of production of plasminogen activator inhibitor (PAI-1). II. Clinical study in patients with insulin resistance].
PAI-1 levels are closely associated with insulin resistance (IR) syndrome, including patients with obesity, hypertension, hypertriglyceridaemia and type 2 diabetes mellitus (DM). Clinical studies demonstrated PAI-1 correlations with insulin (IRI), triglycerides (TG) and body mass index (BMI) values, but these relations have not been confirmed in all studies. In obesity PAI-1 levels correlate with IRI and BMI in the relation to increased adipocyte PAI-1 production, which is dependent on stimulative insulin action. In the case of endothelial hyperproduction in patients with IR elevated PAI-1 levels correlate with TG values. Insulin inhibits induced endothelial PAI-1 production. PAI-1 levels in patients with IR represent cumulative production in described tissues.
Galajda
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I. interná klinika, Jesséniova lekárska fakulta, Martin.
Kubisz
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Mokán
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D017667:Adipocytes / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*
D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1
Multikompartmentový a multifaktoriálny model produkcie inhibítora plazminogénového aktivátora (PAI-1). II. Klinické stúdie u chorých s inzulínovou rezistenciou.