Persistant pre-eclampsia post partum with elevated liver enzymes and hemolytic uremic syndrome.
The spectrum of complications with pre-eclampsia, which may include AFLP (acute fatty liver of pregnancy) as well as the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), is resolved by early delivery. However, the ravages of HUS/TTP (hemolytic uremic syndrome/thrombotic thrombocytopenic purpura) require therapy usually by plasma exchange. Overlap between these two groups of syndromes has occurred on rare occasions and usually requires the therapy of the predominant or more dangerous or threatening form. Such overlap can be appreciated and then treated successfully without residual morbidity. The index case is presented and an extensive review of the two groups of syndromes is provided.
Mahalati
K
K
The Blood Research Laboratory, Department of Pathology, The University of Maryland School of Medicine, Baltimore 21201, USA.
Dawson
R B
RB
Collins
J O
JO
Bell
W R
WR
McCrae
K R
KR
Martin
J N
JN
D000328:Adult; D005260:Female; D017359:HELLP Syndrome; D006463:Hemolytic-Uremic Syndrome; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy