Acute myo-inositol enhances swimming activity in goldfish (short communication).
Inositol in concentrations of 1-4 Mm (but not the control condition: mannitol-glucose) administered in aquarium water showed enhancement of swimming activity of goldfish after acute treatment (5 hours). These data support similar findings in rats. These data suggest that inositol may enhance motor activity which may be of relevance in neuropsychiatric disorders. Future studies of the effects of lithium on this activity, and its potential reversal by inositol may shed light on the possible involvement of the phosphatidyl-inositol second messenger system in this behavior.
Levine
J
J
Stanely Center for the Innovative Treatment of Bipolar Disorder, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213, USA.
Chengappa
K N
KN
Reddy
R
R
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006054:Goldfish; D007294:Inositol / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013550:Swimming / Q000502:physiology*; D013997:Time Factors
D007294:Inositol