[Myocardial function after fluid resuscitation with addition of anisodamine in severely burned rabbits].
OBJECTIVE
To evaluate the effect of fluid resuscitation with addition of anisodamine (Ani) on myocardial function in severely burned rabbits.


METHODS
III degree burn injury covering 25% total body surface area (TBSA) was produced on rabbits. LVSP, LV +/- dp/dtmax were measured with fluid resuscitation alone, administration of Ani alone, and fluid resuscitation plus Ani before burn, immediately after burn and 1, 3, 5, 7 h after burn.


RESULTS
It was showed that myocardial contractility and relaxation were depressed 1 h after burn. Fluid resuscitation alone and administration of Ani alone could significantly improve myocardial contractility and relaxation only within 3 h postburn. With fluid resuscitation plus Ani (5 mg.kg-1), myocardial contractility and relaxation were improved statistically significantly as compared with control group without treatment (P < 0.01), with the values approaching the normal level.


CONCLUSIONS
Our data demonstrate that the administration of Ani (5 mg.kg-1) in addition to fluid resuscitation is beneficial to burn injury, especially to myocardial function, and it provides a promising approach for the future treatment of burns.
Xie
J
J
Department of Pharmacology, Fourth Military Medical University, Xi'an.
Yao
X
X
Zhao
D
D
D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D011897:Random Allocation; D012991:Solanaceous Alkaloids / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D012991:Solanaceous Alkaloids; D014665:Vasodilator Agents; C003922:anisodamine