Solid phase synthesis of quinolones.
Solid phase syntheses of ethyl 6-carboxyquinol-4(1H-)-one-3-carboxylate (5) and N-substituted 6-carboxyquinol-4(1H)-one-3-carboxamides 7a-d have been described. Antifilarial in vitro activities of 5,7a-d against Brugia malayi have also been delineated.
Srivastava
S K
SK
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Haq
W
W
Murthy
P K
PK
Chauhan
P M
PM
D000818:Animals; D017178:Brugia malayi / Q000187:drug effects; D002625:Chemistry, Organic / Q000379:methods; D005369:Filaricides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006586:Hexanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009795:Octanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005369:Filaricides; D006586:Hexanes; D009795:Octanes; D015363:Quinolones; C121280:hexyl-6-carboxyquinol-4(1H)-one-3-carboxamide; C121281:octyl-6-carboxyquinol-4(1H)-one-3-carboxamide