title: Anti-HIV pronucleotides: SATE versus phenyl as a protecting group of AZT phosphoramidate derivatives.
abstract: We comparatively studied the decomposition pathways in CEM cell extract of several PHENYL phosphoramidate diesters of AZT. A correlation between anti-HIV activities in TK- cell lines and pharmacokinetic data has been observed. This study would help to design corresponding SATE phosphoramidate diesters which revealed potent anti-HIV properties.
authors.affiliation: Laboratoire de Chimie Bioorganique, UMR CNRS-USTL 5625, Université Montpellier II, France.
authors.forename: T
authors.initials: T
authors.lastname: Beltran
authors.forename: D
authors.initials: D
authors.lastname: Egron
authors.forename: I
authors.initials: I
authors.lastname: Lefebvre
authors.forename: C
authors.initials: C
authors.lastname: Périgaud
authors.forename: A
authors.initials: A
authors.lastname: Pompon
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: A M
authors.initials: AM
authors.lastname: Aubertin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D009943:Organophosphorus Compounds / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D009943:Organophosphorus Compounds; D015215:Zidovudine