Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man.
Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.
Roy
P M
PM
Department of Emergency Medicine, University Hospital of Angers, France. pmroy@chu-angers.fr
Gouello
J P
JP
Pennison-Besnier
I
I
Chennebault
J M
JM
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D000963:Antimetabolites / Q000009:adverse effects*; D016049:Didanosine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015215:Zidovudine / Q000009:adverse effects*
D019380:Anti-HIV Agents; D000963:Antimetabolites; D015215:Zidovudine; D016049:Didanosine