Primary ciliary dyskinesia in Newfoundland dogs.
Primary ciliary dyskinesia was diagnosed in three Newfoundland dogs with histories of chronic rhinitis and bronchopneumonia from an early age. Thoracic radiographs of two of them showed severe, dependent bronchopneumonia and right displacement of the cardiac apex but normal positioning of other organs. Histopathological examination of sections of lung from the other dog showed severe bronchopneumonia. A semen sample from one dog had a high percentage of spermatozoa with abnormal tails and poor progressive motility. Transmission electron microscopy of nasal brushings from all three dogs showed consistent ultrastructural defects in the cilia, including an absence of outer and inner dynein arms, disorganisation of peripheral doublets, occasional supernumerary doublets and singlets, and consistently disorganised basal bodies and foot processes; sections of trachea from one dog also had disorganised basal bodies. Pedigree analysis was consistent with a monogenic autosomal recessive pattern of inheritance for the defect. One dog is still alive, one dog died aged five years two months, and one dog was euthanased aged nine months. This is the first time primary ciliary dyskinesia has been reported in Newfoundland dogs.
Watson
P J
PJ
Herrtage
M E
ME
Peacock
M A
MA
Sargan
D R
DR
D000818:Animals; D002925:Ciliary Motility Disorders / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology*; D004285:Dogs; D005260:Female; D008168:Lung / Q000473:pathology; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D010375:Pedigree; D011014:Pneumonia / Q000662:veterinary; D013094:Spermatozoa / Q000002:abnormalities; D014132:Trachea / Q000473:pathology