[Temporary expression pattern in wound secretions and peripheral wound biopsies].
The local availability of growth factors and oxygen plays an important role in the healing of cutaneous lesions. We were able to quantify the ischemia in a standardized ischemic full-wall flap by measuring the ptiO2, and investigate the healing of defined wounds. The analysis of the immune histochemical section showed a significantly reduced expression of IGF-I in the wound edge of ischemic wounds. Simultaneously the rate of proliferation was reduced here. Probably the local chronic hypoxia leads to reduced IGF-I synthesis and thus to reduced proliferation and delayed wound healing. Further investigation is necessary to confirm this hypothesis. In a clinical study of wounds which had been treated with vacuum sealing we could establish no difference in the concentration of IGF-I in the wound fluid of seriously contaminated wounds in comparison to primary fasciotomy wounds. We therefore postulate a primary endocrinal secretion for IGF-I in cases of cutaneous wound healing; higher local consumption or reduced serum levels could stimulate the autocrinal local secretion of IGF-I. Further investigation is, however, needed in order to confirm this hypothesis.
Coerper
S
S
Abteilung für Allgemeine Chirurgie und Poliklinik, Chirurgische Universitätsklinik Tübingen.
Wagner
S
S
Witte
M
M
Schäffer
M
M
Becker
H D
HD
D000818:Animals; D001706:Biopsy; D015687:Cell Hypoxia / Q000502:physiology; D017719:Diabetic Foot / Q000473:pathology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D051381:Rats; D012867:Skin / Q000293:injuries* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology*
D007334:Insulin-Like Growth Factor I
Das temporäre Expressionsmuster in Wundflüssigkeiten und Wundrandbiopsien.