title: Metabolic abnormalities detected by 1H-MRS in dyscalculia and dysgraphia.
abstract: Proton MRS was performed in a patient with developmental acalculia. The results indicated a focal, wedge-shaped defect in the left temporoparietal brain region near the angular gyrus, with differential decreases in N-acetyl-aspartate, creatine, and choline. These results support the hypothesis that developmental acalculia, like acquired acalculia, is associated with left posterior hemisphere lesions.
authors.affiliation: Neuroimaging Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Levy
authors.forename: I L
authors.initials: IL
authors.lastname: Reis
authors.forename: J
authors.initials: J
authors.lastname: Grafman
mesh_terms: D000293:Adolescent; D000381:Agraphia / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002658:Developmental Disabilities / Q000378:metabolism*; D006236:Handwriting; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008433:Mathematics; D011522:Protons
chemical_list: D011522:Protons