R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.
Berkowitz
R D
RD
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA.
van't Wout
A B
AB
Kootstra
N A
NA
Moreno
M E
ME
Linquist-Stepps
V D
VD
Bare
C
C
Stoddart
C A
CA
Schuitemaker
H
H
McCune
J M
JM
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D013950:Thymus Gland / Q000821:virology*