[Fibronectin mRNA expression in hypertrophic scars].
OBJECTIVE
This study was to compare the content of fibronectin messenger RNA in the normal skin and hypertrophic scars.


METHODS
The mRNA levels of fibronectin were measured by quantitative RT-PCR.


RESULTS
The study revealed that in vivo, the content of fibronectin messenger RNA was higher in hypertrophic scars than in normal skin.


CONCLUSIONS
It indicates that altered regulation of extracellular matrix components is an important factor for abnormal human wound healing.
Yang
Y
Y
Wound Healing Unit, 304th Hospital, Beijing.
Fu
X
X
Wang
Y
Y
D000293:Adolescent; D000328:Adult; D017439:Cicatrix, Hypertrophic / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism*
D005353:Fibronectins; D012333:RNA, Messenger