[Changes in the level of fructose-2,6-biphosphate in peripheral blood lymphocytes in patients with diabetes mellitus].
Variation of fructose 2,6-bisphosphate (F-2,6-P2) content in the peripheral blood lymphocytes of patients with diabetes mellitus (type II) was investigated. The 2.5-fold increase of F-2,6-P2 level compared with to the control group was observed in untreated patients with early stage of the disease. In patients using of peroral antidiabetic drugs that corrected diabetes F-2,6-P2 level was approached to the normal one. At the same time F-2,6-P2 content decreases in patients with severe (noncorrected) diabetes mellitus. The possible mechanisms of regulation of lymphocyte F-2,6-P2 concentration in normal conditions and diabetes mellitus are discussed.
Korovkin
B F
BF
Russian Academy of Medical Sciences Institute of Biomedical Chemistry RAMN, Moscow.
Beliaeva
N F
NF
Kraevoĭ
S A
SA
Golubev
M A
MA
Gorodetskiĭ
V K
VK
Markova
M S
MS
Kol'chenko
O L
OL
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005635:Fructosediphosphates / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate
Izmenenie soderzhaniia fruktozo-2,6-bifosfata v limfotsitakh perifericheskoĭ krovi bol'nykh sakharnym diabetom.