title: del(6)(q12q15) as the sole cytogenetic anomaly in a case of solitary infantile myofibromatosis.
abstract: We describe a case of light microscopically typical solitary, infantile myofibromatosis in a 6-month old boy. The myofibroblastic differentiation of the tumor was supported by immunohistochemical and ultrastructural analyses. Cytogenetic and FISH analyses revealed a pseudodiploid karyotype with an interstitial deletion of the long arm of one chromosome 6, del(6)(q12q15), as the sole anomaly. The results demonstrate the usefulness of cytogenetics and FISH in distinguishing this type of lesion from infantile fibrosarcoma. To the best of our knowledge this is the first cytogenetic analysis of solitary infantile myofibromatosis.
authors.affiliation: Lundberg Laboratory for Cancer Research, Department of Pathology, Goteborg University, Sahlgrenska University Hospital, SE-413 45 Goteborg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Stenman
authors.forename: N
authors.initials: N
authors.lastname: Nadal
authors.forename: S
authors.initials: S
authors.lastname: Persson
authors.forename: B
authors.initials: B
authors.lastname: Gunterberg
authors.forename: L
authors.initials: L
authors.lastname: Angervall
mesh_terms: D002675:Child, Preschool; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D018224:Myofibromatosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D014953:Wrist / Q000473:pathology*