title: Hematocrit and stroke in black Africans under tropical climate and meteorological influence.
abstract: OBJECTIVE
  To assess the relationship between hematocrit and risk of fatal and non-fatal stroke in conjunction with meteorological variations.
  
  
  METHODS
  Prospective study of a series of Africans living in Kinshasa, Congo, followed up for 5 years.
  
  
  METHODS
  A total of 1,032 unselected patients consecutively admitted to hospitals for acute stroke. Main outcome measures. Fatal and non-fatal ischemic or hemorrhagic strokes. The association of hematocrit with stroke morbidity and mortality and meteorological variables were evaluated by simple or multiple linear regression and logistic regression.
  
  
  RESULTS
  Patients were aged 53.7 +/- 12.1 years. Hematocrit was mostly correlated with mean ambient air temperature (r = 0.124; p < 0.001) and atmospheric pressure at 6 a.m GMT (r = 0.157; p < 0.001). Patients with hematocrit > 40% presented the highest levels of systolic blood pressure, fibrinogen, body temperature, resting heart rate, duration of coma and incidence of all stroke types and ischemic stroke (p < 0.001). Hematocrit > 40% was associated with stroke mortality (Odds ratio, 6.2, 4.5-8.6; p < 0.001). The risk of stroke mortality was multiplied by 21, 18.3 and 4.2 in conditions of a mean ambient air temperature > 28 degrees C, atmospheric pressure 975-977 mm Hg and body temperature > 37 degrees C respectively.
  
  
  CONCLUSIONS
  Our study suggests that higher hematocrit is associated with an increased risk of stroke morbidity and mortality, particularly ischemic stroke at noon. This risk is probably mediated by increased susceptibility of African older hypertensive subjects to meteorological variations.
authors.affiliation: Department of Internal Medicine, Kinshasa University Clinics, Democratic Republic of Congo.
authors.forename: B
authors.initials: B
authors.lastname: Longo-Mbenza
authors.forename: L B
authors.initials: LB
authors.lastname: Phanzu-Mbete
authors.forename: J R
authors.initials: JR
authors.lastname: M'Buyamba-Kabangu
authors.forename: K
authors.initials: K
authors.lastname: Tonduangu
authors.forename: M
authors.initials: M
authors.lastname: Mvunzu
authors.forename: D
authors.initials: D
authors.lastname: Muvova
authors.forename: E
authors.initials: E
authors.lastname: Lukoki-Luila
authors.forename: M
authors.initials: M
authors.lastname: Bayekula
authors.forename: W
authors.initials: W
authors.lastname: Odio
authors.forename: V
authors.initials: V
authors.lastname: Kintoki
authors.forename: M
authors.initials: M
authors.lastname: Mbala-Mukendi
authors.forename: P
authors.initials: P
authors.lastname: Tshiamala
authors.forename: M
authors.initials: M
authors.lastname: Kilembi
authors.forename: L
authors.initials: L
authors.lastname: Katalay
authors.forename: M
authors.initials: M
authors.lastname: Lelo-Tshinkwela
authors.forename: E K
authors.initials: EK
authors.lastname: Ndoma
authors.forename: M
authors.initials: M
authors.lastname: Mpaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001274:Atmospheric Pressure; D044383:Black People; D001831:Body Temperature / Q000502:physiology; D002545:Brain Ischemia / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology*; D015023:Democratic Republic of the Congo; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D006973:Hypertension / Q000150:complications; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008685:Meteorological Concepts; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013696:Temperature; D014329:Tropical Climate
chemical_list: D005340:Fibrinogen