Pharmacokinetics of atenolol enantiomers in 12 Chinese healthy men.
OBJECTIVE
To study the pharmacokinetics of atenolol (Ate) stereoisomers in Chinese.


METHODS
A single oral dose of 100 mg of racemic Ate tablets were given to 12 healthy volunteers of Han nationality. Plasma and urine concentrations were determined by the reversed phase HPLC method.


RESULTS
The disposition of d-Ate and l-Ate was conformed to one-compartment model. Maximal plasma concentration (Cmax): l-Ate (331 +/- 79) micrograms.L-1, d-Ate (342 +/- 78) micrograms.L-1. Area under blood concentration-time curve (AUC): d-Ate (2635 +/- 610) micrograms.h.L-1, l-Ate (2442 +/- 588) micrograms.h.L-1. Renal clearance (Clr): l-Ate (6.9 +/- 1.2) L.h-1, d-Ate (6.5 +/- 1.3) L.h-1.


CONCLUSIONS
The disposition of Ate stereoisomers is of stereoselectivity.
Wang
X M
XM
Division of Clinical Pharmacology, Guangdong Cardiovascular Institute, China.
Yu
X Y
XY
Lin
S G
SG
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000328:Adult; D019540:Area Under Curve; D001262:Atenolol / Q000493:pharmacokinetics*; D001682:Biological Availability; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D001262:Atenolol