Beta-amyloid: Alzheimer's disease and brain beta-amyloidoses.
This review considers some aspects of the biochemistry of beta-amyloid, a protein which produces insoluble deposits in the brain. These deposits are a specific morphological feature of Alzheimer's disease, Down's syndrome, and senile dementia. Our contribution to the concept of a soluble form of beta-amyloid as of a normal human protein is presented.
Koudinova
N V
NV
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119832, Russia. inst@ibmh.msk.su
Berezov
T T
TT
Koudinov
A R
AR
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000686:Amyloidosis / Q000378:metabolism*; D006801:Humans
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor