[The effect of captopril and enalapril on the cerebral circulation of normotensive rats].
Kaptopril and enalapril caused a stable decrease of arterial pressure and resistance of cerebral vessels in experiments on narcotized rats with artificial ventilation of the lungs. No significant changes occurred in the flow of blood in the brain because the drug under study potentiated autoregulatory reactions of the cerebral vessels in response to the decrease in arterial pressure.
Adzhienko
L M
LM
Department of Pharmacology, Pyatigorsk State Pharmaceutical Academy, Russia.
Isaak
A D
AD
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004656:Enalapril; D002216:Captopril
Vliianie kaptoprila i énalaprila na mozgovoe krovoobrashchenie normotenzivnykh krys.