Tyrosinase inhibitory p-coumaric acid from ginseng leaves.
By bioassay-guided fractionation using mushroom tyrosinase, p-coumaric acid was characterized as the principal tyrosinase inhibitor from the fresh leaves of Panax ginseng (Araliaceae). It inhibited the oxidation of L-tyrosine more strongly than that of L-3, 4-dihydroxyphenylalanine (L-DOPA) by this enzyme. On the basis of this finding, various related phenylpropanoid analogues were also tested in order to gain new insights into their structural criteria.
Lim
J Y
JY
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA.
Ishiguro
K
K
Kubo
I
I
D000363:Agaricales / Q000201:enzymology; D003373:Coumaric Acids / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D007980:Levodopa / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D005894:Panax / Q000737:chemistry*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D011422:Propionates
D003373:Coumaric Acids; D004791:Enzyme Inhibitors; D010636:Phenols; D010936:Plant Extracts; D011422:Propionates; D007980:Levodopa; D014442:Monophenol Monooxygenase; C495469:p-coumaric acid