No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke.
Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke. We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.
MacLeod
M J
MJ
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, UK.
Dahiyat
M T
MT
Cumming
A
A
Meiklejohn
D
D
Shaw
D
D
St Clair
D
D
D000368:Aged; D000483:Alleles; D001224:Aspartic Acid; D002545:Brain Ischemia / Q000235:genetics*; D002561:Cerebrovascular Disorders / Q000235:genetics*; D005260:Female; D005838:Genotype; D018698:Glutamic Acid; D006801:Humans; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic
D001224:Aspartic Acid; D018698:Glutamic Acid; D019001:Nitric Oxide Synthase