title: Viable tissue in an area of severely reduced perfusion demonstrated with I-123 iomazenil brain SPECT imaging of benzodiazepine receptors.
abstract: A 70-year-old woman who experienced transient left hemiparesis had 90% stenosis of the right internal carotid artery. CT revealed small low-density areas in the subcortical frontal area. Baseline cerebral blood flow was reduced, and vasoreactivity was poor in the right frontoparietal area according to I-123 IMP brain SPECT with acetazolamide. The distribution of I-123 iomazenil was normal on the delayed SPECT image but reduced in the early SPECT image, mimicking baseline cerebral blood flow. The distribution of I-123 iomazenil SPECT on the delayed image reflected the normal binding potential of the benzodiazepine receptor and thus identified viable tissue in an area of severely reduced perfusion. These findings were confirmed by positron emission tomography.
authors.affiliation: National Cardiovascular Center, Department of Radiology, Osaka, Japan. khysd@hsp.ncvc.go.jp
authors.forename: K
authors.initials: K
authors.lastname: Hayashida
authors.forename: K
authors.initials: K
authors.lastname: Fukuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: N
authors.initials: N
authors.lastname: Kume
authors.forename: I H
authors.initials: IH
authors.lastname: Cho
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000086:Acetazolamide; D000368:Aged; D015901:Angiography, Digital Subtraction; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives*; D006801:Humans; D007457:Iodine Radioisotopes; D010101:Oxygen Consumption; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A / Q000378:metabolism*; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil; D000086:Acetazolamide