title: Moderate renal failure in association with prolonged acquired hypothyroidism in children.
abstract: We evaluated five children with prolonged primary hypothyroidism and noted a significant reduction in renal function (40%), which was reversible with hormonal replacement. This decline was higher than reported in adults and was of sufficient magnitude to warrant altering drug-dosing schedules. Furthermore, patients with moderately reduced renal function should be carefully evaluated for signs and symptoms of hypothyroidism.
authors.affiliation: Department of Pediatrics, Montreal Children's Hospital, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Al-Fifi
authors.forename: C
authors.initials: C
authors.lastname: Girardin
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: C
authors.initials: C
authors.lastname: Rodd
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D000367:Age Factors; D002648:Child; D003287:Contrast Media; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D007483:Iothalamic Acid; D007677:Kidney Function Tests; D008297:Male; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000209:etiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013972:Thyrotropin / Q000097:blood / Q000627:therapeutic use
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid; D013972:Thyrotropin