Efficacy and side effects of deferiprone (L1) in thalassemia patients not compliant with desferrioxamine.
We report our experience with deferiprone (L1) (DFP) in 17 thalassemic patients, followed up in one center in Lebanon, who were initially on desferrioxamine and then shifted to DFP at a dose of 50-75 mg/kg/day as the sole chelator during 1-year follow-up. All 17 patients were compliant with therapy and there was no change in physical examination over the study period. Eight patients (47.1%) were positive for hepatitis C virus (HCV) antibodies. Urinary iron excretion was 21.8 +/- 14 mg/24 h (mean +/- SD) 1 week after starting DFP and dropped 12 months later to 13 +/- 7.4 mg/24 h (p = 0.009, paired t test). The initial serum ferritin level was 3,863 +/- 2,344 microg/l which dropped to 3,179 +/- 2,075 at 12 months after starting therapy (p = 0.07). HCV-negative patients as a group exhibited a significant decrease in serum ferritin after 6 and 12 months of DFP therapy (3,942 +/- 2,739 vs. 2,341 +/- 1,179 and 2,681 +/- 1,519 microg/l; p < 0.03 and p < 0.05, respectively). The most frequent side effects were joint pain, stiffness or swelling in 6 patients (35.3%), and nausea in 7 patients (41.2%), but these were well tolerated and did not require stopping treatment.
Taher
A
A
Chronic Care Center, American University of Beirut Medical Center, Beirut, Lebanon.
Chamoun
F M
FM
Koussa
S
S
Saad
M A
MA
Khoriaty
A I
AI
Neeman
R
R
Mourad
F H
FH
D000293:Adolescent; D000328:Adult; D018771:Arthralgia / Q000139:chemically induced; D002648:Child; D000077543:Deferiprone; D003676:Deferoxamine / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D007501:Iron / Q000652:urine; D007502:Iron Chelating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009325:Nausea / Q000139:chemically induced; D011728:Pyridones / Q000008:administration & dosage* / Q000009:adverse effects; D013789:Thalassemia / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome; D016312:Treatment Refusal
D018937:Hepatitis C Antibodies; D007502:Iron Chelating Agents; D011728:Pyridones; D000077543:Deferiprone; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine