title: Inhibition of cathepsin D by tripeptides containing statine analogs.
abstract: Various analogs of statine, a remarkable amino acid component of the protease inhibitor pepstatine, were synthesized and evaluated as tripeptide derivatives for their activity against cathepsin D and HIV-1 protease.
authors.affiliation: CNRS UMR 133, ENSCP, Paris, France. bessodes@infobiogen.fr
authors.forename: M
authors.initials: M
authors.lastname: Bessodes
authors.forename: K
authors.initials: K
authors.lastname: Antonakis
authors.forename: J
authors.initials: J
authors.lastname: Herscovici
authors.forename: M
authors.initials: M
authors.lastname: Garcia
authors.forename: H
authors.initials: H
authors.lastname: Rochefort
authors.forename: F
authors.initials: F
authors.lastname: Capony
authors.forename: Y
authors.initials: Y
authors.lastname: Lelièvre
authors.forename: D
authors.initials: D
authors.lastname: Scherman
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology*; D002402:Cathepsin D / Q000037:antagonists & inhibitors*; D017320:HIV Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010436:Pepstatins / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000596:Amino Acids; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D010436:Pepstatins; D011480:Protease Inhibitors; C014195:Streptomyces pepsin inhibitor; D002402:Cathepsin D; C031375:pepstatin; C013165:statine