title: Treatment of mandibular osteoradionecrosis by cancellous bone grafting.
abstract: OBJECTIVE
  This study was undertaken to evaluate a new method in the treatment of mandibular osteoradionecrosis.
  
  
  METHODS
  Eight patients, seven male and one female, with a mean age of 64 years (range, 43 to 67 years), suffering from osteoradionecrosis of the mandible, two bilaterally and six unilaterally, were treated. Five initially had hyperbaric oxygen (HBO) followed by sequestrectomy, and three had sequestrectomy alone. Because healing failed to occur, all patients were treated by removal of the necrotic bone in the affected part of the mandible and filling the defect with compressed particulated cancellous bone and marrow from the tibia. The patients were observed for an average period of 39 months (range, 20 to 93 months).
  
  
  RESULTS
  Primary healing was achieved in two patients with unilateral osteoradionecrosis and HBO treatment. In another patient treated with HBO primary healing occurred on one side while the other healed secondarily. In the remaining five patients, complete secondary healing took place, but it was complicated in three patients by fistulas, two of which were associated with fractures of the mandibular body. The fistulas were excised, and complete healing of the soft tissues occurred, but the fractures resulted in pseudarthrosis.
  
  
  CONCLUSIONS
  The technique presented in this study can be useful in the treatment of osteoradionecrosis as an alternative to continuity resection and reconstruction with free osteocutaneous flaps, but, whenever possible, it should be proceeded by HBO treatment.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Jisander
authors.forename: B
authors.initials: B
authors.lastname: Grenthe
authors.forename: L
authors.initials: L
authors.lastname: Salemark
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D016025:Bone Transplantation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011859:Radiography; D013977:Tibia / Q000637:transplantation