Synthesis of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides.
The preparation of 5'-thioalkyl, sulfoxide and sulfone pyrimidine nucleosides is [4-11] is described. The key steps of this synthesis are the nucleophilic displacements of a chlorine by a thioalkyl sodium salt or the direct introduction of the thioalkyl group under Mitsunobu conditions.
Agrofoglio
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LA
I.C.O.A., associé au CNRS, Faculté des Sciences, Orléans-France.
Girard
F
F
Fleury
F
F
Léonce
S
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000473:pathology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D011741:Pyrimidine Nucleosides