title: Long-term results after surgical management of chronic pancreatitis.
abstract: OBJECTIVE
  Long-term outcome in surgery for chronic pancreatitis remains relatively unknown.
  
  
  METHODS
  Between 1963 and 1993, we performed 123 pancreatic resections and 35 drainage procedures for severe chronic pancreatitis. We reviewed 131 patients with a mean follow-up of 48 months (4 months to 18 years).
  
  
  RESULTS
  Actual 10-year survival was 82% for nonalcoholic patients and 51% for alcoholic pancreatitis. Pain was successfully treated in 71% with pancreatic resection and in 42% with drainage procedures (p<0.01). Although post-operative diabetes mellitus occurred in 56% of patients after pancreatic resection, long-term nutritional status was similar after pancreatic resection and drainage procedures. Weight gain could be observed in 75 patients (47%) and quality-of-life was good to excellent in 97 patients (74%).
  
  
  CONCLUSIONS
  In conclusion, long-term survival was mainly conditioned by the etiology of the disease. Pancreatic resections were more successful in treating intractable pain than drainage and required fewer re-interventions. As presumed, resections were associated with a higher rate of diabetes mellitus, but this, however, had no impact on long-term nutritional status and quality-of-life.
authors.affiliation: Clinic and Policlinic of Digestive Surgery, Department of Surgery, University Hospital of Geneva, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Bühler
authors.forename: F
authors.initials: F
authors.lastname: Schmidlin
authors.forename: M
authors.initials: M
authors.lastname: de Perrot
authors.forename: F
authors.initials: F
authors.lastname: Borst
authors.forename: G
authors.initials: G
authors.lastname: Mentha
authors.forename: P
authors.initials: P
authors.lastname: Morel
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004322:Drainage; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009752:Nutritional Status; D010180:Pancreatectomy; D010192:Pancreatic Pseudocyst / Q000401:mortality / Q000601:surgery; D016577:Pancreaticoduodenectomy; D010195:Pancreatitis / Q000401:mortality / Q000601:surgery*; D019512:Pancreatitis, Alcoholic / Q000401:mortality / Q000601:surgery; D011183:Postoperative Complications / Q000401:mortality; D011788:Quality of Life; D015996:Survival Rate; D016896:Treatment Outcome