title: Magnetization transfer measurements in normal-appearing cerebral white matter in patients with chronic obstructive hydrocephalus.
abstract: OBJECTIVE
  The purpose of this work was to assess the presence of subtle changes in normal-appearing white matter on T2-weighted MR images in patients with chronic obstructive hydrocephalus using magnetization transfer (MT) measurements.
  
  
  METHODS
  In 12 patients with chronic obstructive hydrocephalus, MT ratios (MTRs) of normal-appearing rostral (PR) and caudal (PC) periventricular white matter, of the genu (CG) and the splenium (CS) of the corpus callosum, and of the thalamus (TH) were measured and compared with those of 16 healthy control subjects.
  
  
  RESULTS
  We found a significantly lower MTR in chronic obstructive hydrocephalus than in the normal group for PR, PC, CG, and CS but not for TH.
  
  
  CONCLUSIONS
  Our study shows that MT measurements give additional information that cannot be gained by conventional SE MRI, suggesting that chronic obstructive hydrocephalus is associated with diffuse white matter damage that also affects normal-appearing cerebral white matter.
authors.affiliation: Department of Neuroradiology, University of Heidelberg Medical School, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Hähnel
authors.forename: K
authors.initials: K
authors.lastname: Münkel
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: S
authors.initials: S
authors.lastname: Heiland
authors.forename: M
authors.initials: M
authors.lastname: Reidel
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: A
authors.initials: A
authors.lastname: Aschoff
authors.forename: K
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged