title: Receptor mediated subversion of macrophage cytokine production by intracellular pathogens.
abstract: Appropriately regulated immune responses depend on the controlled production of cytokines from antigen presenting cells. IL-12 synthesis is tightly regulated by several redundant mechanisms. One mechanism of IL-12 regulation involves the cross-linking of surface receptors on macrophages. This pathway may be exploited by intracellular pathogens of macrophages to inhibit IL-12 production and delay or prevent the development of cell mediated immunity.
authors.affiliation: Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA. dmmosser@astro.temple.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Mosser
authors.forename: C L
authors.initials: CL
authors.lastname: Karp
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology; D006660:Histoplasmosis / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D018664:Interleukin-12 / Q000096:biosynthesis*; D007896:Leishmaniasis / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008457:Measles / Q000276:immunology; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D011971:Receptors, Immunologic; D018664:Interleukin-12