title: A case of amyloid goiter secondary to Crohn's disease.
abstract: We herewith report a case of amyloid goiter secondary to Crohn's disease. The patient had been diagnosed as having Crohn's disease at the age of 15, and underwent right hemicolectomy at age 20. When he was 26 years old he complained of swelling of the anterior neck. Both TSH and thyroid hormones were within the normal range, and anti-thyroglobulin and anti-microsomal antibodies were negative. Only thyroglobulin was noticeably above the normal range. During the next year his goiter enlarged further and because he had a feeling of pressure he underwent total thyroidectomy. The presence of amyloid A protein in his surgical specimen led to the diagnosis of amyloid goiter. Although most cases of secondary amyloidosis are known to develop in neoplasms or chronic inflammatory diseases, our patient had no illness other than Crohn's disease. Perusal of literature revealed that Crohn's disease is rarely a cause of amyloid goiter.
authors.affiliation: Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Habu
authors.forename: H
authors.initials: H
authors.lastname: Watanobe
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Suda
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D003082:Colectomy; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery; D006042:Goiter / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008297:Male; D000685:Serum Amyloid A Protein / Q000032:analysis; D013954:Thyroglobulin / Q000097:blood; D013961:Thyroid Gland / Q000737:chemistry / Q000000981:diagnostic imaging; D013965:Thyroidectomy; D014463:Ultrasonography
chemical_list: D000685:Serum Amyloid A Protein; D013954:Thyroglobulin