title: Respiratory allergy to mushroom spores: not well recognized, but relevant.
abstract: BACKGROUND
  Although basidiospores are a major component of the air spora in many parts of the world, their clinical significance as triggers of respiratory allergy has rarely been demonstrated. Therefore, the class of basidiomycetes as an aeroallergen is not well known.
  
  
  OBJECTIVE
  To demonstrate a cause and effect relationship between respiratory allergy and basidiospores, we illustrate this case report of a 38-year-old housewife.
  
  
  METHODS
  Skin prick test, immunoblot, and active anterior rhinomanometry were used as diagnostic tools to verify specific reactivity of a Pleurotus pulmonalis spore extract. Two atopic subjects served as controls.
  
  
  RESULTS
  The skin prick test positive study subject reacted with subjective and objective signs including a significant drop of the FEV1 by nasal challenge at a concentration of 0.1 mg/mL of the Pleurotus spore extract while both controls were negative even at a higher test concentration. IgE-immunoblot revealed several distinct bands in the serum of the Pleurotus-sensitized subject.
  
  
  CONCLUSIONS
  Spores of Pleurotus pulmonalis, a common mushroom of the fungal class of basidiomycetes, can cause specific, IgE-mediated acute rhinoconjuncivitis and asthma in sensitized individuals.
authors.affiliation: Institute of Immunology and Allergology, University Hospital, Bern, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Helbling
authors.forename: F
authors.initials: F
authors.lastname: Gayer
authors.forename: K A
authors.initials: KA
authors.lastname: Brander
mesh_terms: D000328:Adult; D000363:Agaricales / Q000276:immunology*; D003231:Conjunctivitis / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D015151:Immunoblotting; D007073:Immunoglobulin E / Q000032:analysis; D012130:Respiratory Hypersensitivity / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012882:Skin Tests; D013172:Spores, Fungal / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E