Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.
The human multidrug resistance P-glycoprotein is an ATP-dependent drug pump that extrudes a broad range of cytotoxic agents from the cell. Its physiological role may be to protect the body from endogenous and exogenous cytotoxic agents. The protein has clinical importance because it contributes to the phenomenon of multidrug resistance during chemotherapy. In this review, we discuss some of the results obtained by using molecular biology and protein chemistry techniques for studying this important and intriguing protein.
Loo
T W
TW
Department of Medicine, University of Toronto, ON, Canada.
Clarke
D M
DM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000502:physiology*; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use; D001665:Binding Sites; D016923:Cell Death; D002470:Cell Survival; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis; D018432:Drug Resistance, Multiple; D017320:HIV Protease Inhibitors / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D017510:Protein Folding; D013329:Structure-Activity Relationship; D014357:Trypsin / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D000596:Amino Acids; D000970:Antineoplastic Agents; D018076:DNA, Complementary; D017320:HIV Protease Inhibitors; D000255:Adenosine Triphosphate; D014357:Trypsin