title: Surface texturing and coating of biomaterial implants: effects on tissue integration and fibrosis.
abstract: To determine whether texturing and coating have additive effects in promoting tissue integration and inhibiting fibrosis, we evaluated smooth silicone rubber (SSR), textured silicone rubber (TSR), porous silicone rubber (PSR), expanded polytetrafluoroethylene (ePTFE), and porous polyurethane (PPU) subcutaneous implants in eight minipigs. Some of the implants were coated with type IV collagen (Col) and/or fibronectin (Fn). At 6 months, we removed the implants and examined them microscopically. Texturing was more important than Col and Fn in reducing fibrosis and inflammation. The PSR yielded the best response, including reduced fibrosis and inflammation, satisfactory adherence, and no dystrophic mineralization.
authors.affiliation: Department of Comparative Cardiovascular Services, Texas Heart Institute, Houston 77225-0345, USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: D L
authors.initials: DL
authors.lastname: Clapper
authors.forename: D A
authors.initials: DA
authors.lastname: Deferrari
authors.forename: S P
authors.initials: SP
authors.lastname: Hu
authors.forename: W J
authors.initials: WJ
authors.lastname: Seare
authors.forename: P P
authors.initials: PP
authors.lastname: Capek
authors.forename: J
authors.initials: J
authors.lastname: Armstrong
authors.forename: M G
authors.initials: MG
authors.lastname: McGee
authors.forename: L A
authors.initials: LA
authors.lastname: Billings
authors.forename: J M
authors.initials: JM
authors.lastname: Fuqua
authors.forename: S M
authors.initials: SM
authors.lastname: Parins
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D005355:Fibrosis; D007249:Inflammation / Q000517:prevention & control; D008853:Microscopy; D019736:Prostheses and Implants; D013552:Swine; D013556:Swine, Miniature
chemical_list: D001672:Biocompatible Materials