title: Reproducible localization of interictal epileptiform discharges using EEG-triggered fMRI.
abstract: We report preliminary experiences using fMRI triggered by EEG to localize the site of interictal epileptiform activity. EEG was recorded in the scanner and monitored on-line; the recording quality was good enough to allow the clear identification of spikes in the EEG. Snap-shot EPI was performed 2-4 s after an epileptiform discharge ('spike') or after at least 10 s of background activity ('rest') was observed. A pixel-by-pixel t-test was performed between the 'rest' and the 'spike' images to determine areas of significant activation. Significant activation was obtained in a patient with epilepsy. To assess the reliability and reproducibility of the technique, the patient was scanned on four separate occasions with similar areas being activated in all the studies, confirming the validity of the result.
authors.affiliation: Department of Clinical Neurology, Institute of Neurology, London, UK. m.symms@ion.ucl.ac.uk
authors.forename: M R
authors.initials: MR
authors.lastname: Symms
authors.forename: P J
authors.initials: PJ
authors.lastname: Allen
authors.forename: F G
authors.initials: FG
authors.lastname: Woermann
authors.forename: G
authors.initials: G
authors.lastname: Polizzi
authors.forename: K
authors.initials: K
authors.lastname: Krakow
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
authors.forename: D R
authors.initials: DR
authors.lastname: Fish
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D004660:Encephalitis / Q000150:complications / Q000503:physiopathology; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D017029:Epilepsy, Complex Partial / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015203:Reproducibility of Results