title: Postoperative toxic shock syndrome caused by a highly virulent methicillin-resistant Staphylococcus aureus strain.
abstract: We report on a rare fatal case of postoperative toxic shock syndrome caused by infection with a highly virulent methicillin-resistant Staphylococcus aureus strain, designated Sak-1, which was found to be characteristic in its increased production of toxic shock syndrome toxin 1 in human whole blood (about 30-fold more than produced in Tod Hewitt broth). The strain also produced a high level of toxic shock syndrome toxin 1 in the circulating blood of mice experimentally infected with the strain.
authors.affiliation: Department of Bacteriology, Juntendo University, Tokyo, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Cui
authors.forename: H
authors.initials: H
authors.lastname: Kasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Hanaki
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
mesh_terms: D000328:Adult; D000818:Animals; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000096:biosynthesis; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D051379:Mice; D011183:Postoperative Complications / Q000382:microbiology*; D012772:Shock, Septic / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism / Q000472:pathogenicity*; D018089:Superantigens; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal