title: Retinal sparing by selective retinal pigment epithelial photocoagulation.
abstract: OBJECTIVE
  To investigate whether photocoagulation of the retinal pigment epithelium is possible with sparing of the photoreceptors.
  
  
  METHODS
  Mild laser effects of a neodymium:yttrium-lithium-fluoride (Nd:YLF) laser (527 nm) were applied to 17 patients. To establish the necessary energy, test exposures were performed to the lower macula (laser variables: 1.7 microseconds, 100 and 500 pulses applied in a train at 500 Hz, 20-130 microJ, 160 microm). Of 179 test lesions, 73 were followed up at various time intervals up to 1 year by performing microperimetry directly on top of the laser lesions.
  
  
  RESULTS
  All of the test lesions were at the threshold of retinal pigment epithelial disruption, and none of the laser effects were visible by ophthalmoscopy during photocoagulation; they were detectable only by fluorescein angiography. After exposure with 500 pulses, retinal defects were detected in up to 73% of the patients (100 microJ) after the first day. Most of these defects were no longer detectable after 3 months. After exposure with 100 pulses, no defects could be detected with 70 and 100 microJ after 1 day. The absence of microscotomas in the follow-up period suggests that retinal damage was minimal or, if it occurred, was functionally repaired.
  
  
  CONCLUSIONS
  By choosing proper energy and number of pulses, it is possible to produce retinal pigment epithelial effects with no subsequent retinal damage detectable by microperimetry.
authors.affiliation: Department of Ophthalmology, University of Regensburg, Germany. johann.roider@klinik.uni-regensburg.de
authors.forename: J
authors.initials: J
authors.lastname: Roider
authors.forename: R
authors.initials: R
authors.lastname: Brinkmann
authors.forename: C
authors.initials: C
authors.lastname: Wirbelauer
authors.forename: H
authors.initials: H
authors.lastname: Laqua
authors.forename: R
authors.initials: R
authors.lastname: Birngruber
mesh_terms: D000328:Adult; D005131:Eye Injuries / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D010857:Pigment Epithelium of Eye / Q000503:physiopathology / Q000601:surgery*; D012160:Retina / Q000293:injuries / Q000503:physiopathology*; D012164:Retinal Diseases / Q000503:physiopathology / Q000601:surgery*; D014792:Visual Acuity; D058609:Visual Field Tests