title: [Thyroid disorders associated with interferon treatment in patients with chronic viral hepatitis or multiple sclerosis].
abstract: BACKGROUND
  Alpha and beta interferon (IFN-alpha and beta) treatment is associated with the synthesis of thyroid autoantibodies and the development of autoimmune thyroid diseases.
  
  
  RESULTS
  We have retrospectively evaluated their effect in patients with chronic viral hepatitis (CH) (n = 118) and multiple esclerosis (ME) (n = 10). Thyroid dysfunction has been detected in 7.4% of patients, and seroconversion in 4.7%.
  
  
  CONCLUSIONS
  Pre-treatment antithyroid antibodies do not predispose to altered thyroid function, after IFN therapy; their presence should not contraindicate IFN treatment.
authors.affiliation: Secciones de Endocrinología, Hospital Severo Ochoa, Leganés, Madrid. cvazquez@hso.es
authors.forename: J I
authors.initials: JI
authors.lastname: Diago
authors.forename: D
authors.initials: D
authors.lastname: del Olmo
authors.forename: V
authors.initials: V
authors.lastname: Alcázar
authors.forename: P
authors.initials: P
authors.lastname: Martínez de Icaya
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez
authors.forename: P
authors.initials: P
authors.lastname: Martínez Montiel
mesh_terms: D000208:Acute Disease; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis / Q000276:immunology; D000998:Antiviral Agents / Q000009:adverse effects*; D005260:Female; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012189:Retrospective Studies; D013960:Thyroid Function Tests / Q000379:methods; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000998:Antiviral Agents; D016898:Interferon-alpha; D007453:Iodide Peroxidase
vernacular_title: Alteraciones tiroideas asociadas al tratamiento con interferón en pacientes con hepatitis crónica viral o esclerosis múltiple.