Synthesis of the tBuSATE pronucleotide of AZT by two different synthetic approaches.
A large scale synthesis of the tBuSATE pronucleotide of AZT was required for in vivo studies. A comparative synthesis of this derivative by phosphoramidite and monophosphate approaches is reported.
Lannuzel
M
M
Laboratoire de Chimie Bioorganique, U.M.R. 5625 C.N.R.S.-U.S.T.L., Université de Montpellier II, France.
Egron
D
D
Imbach
J L
JL
Gosselin
G
G
Périgaud
C
C
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D019380:Anti-HIV Agents; D015215:Zidovudine