Determination of embutramide and pentobarbital in meat and bone meal by gas chromatography-mass spectrometry.
An analytical procedure, consisting of multiple steps, was developed for the analysis of meat and bone meal for two veterinary drugs, embutramide and pentobarbital, used for euthanasia. After a combined extraction, embutramide was converted to its trimethylsilylether derivative and pentobarbital was methylated. Both analytes were determined by gas chromatography-mass spectrometry in the electron impact or chemical ionisation mode. Limits of determination and identification were between 50 and 100 micrograms kg-1 depending on the compound and the ionisation technique applied. Particular attention was focused on the identification of the analytes.
Hooijerink
D
D
Rijks-Kwaliteitsinstituut voor land- en tuinbouwprodukten (RIKILT-DLO), State Institute for Quality Control of Agricultural Products, Wageningen, The Netherlands.
Schilt
R
R
Brouwer
B
B
van Bennekom
E
E
D000577:Amides / Q000032:analysis; D000777:Anesthetics / Q000032:analysis; D000818:Animals; D004350:Drug Residues / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006993:Hypnotics and Sedatives / Q000032:analysis*; D008460:Meat / Q000032:analysis*; D008461:Meat Products / Q000032:analysis; D010424:Pentobarbital / Q000032:analysis*; D019155:Veterinary Drugs / Q000032:analysis*
D000577:Amides; D000777:Anesthetics; D006993:Hypnotics and Sedatives; D019155:Veterinary Drugs; C059324:embutramide; D010424:Pentobarbital