Synthesis of analogues of 5'-mono-, 5'-di-, and 5'-triphosphate-AZT for the development of specific enzyme immunoassay for monitoring of intracellular levels of AZT-MP, AZT-DP, and AZT-TP.
The synthesis of analogue compounds of polyphosphorylated AZT is described. The compounds are designed to raise specific antibodies against AZT-MP, -DP and -TP in rabbits.
Brossette
T
T
Laboratoire de Synthèse Bioorganique associé au CNRS, Université Louis Pasteur, Faculté de pharmacie, Illkirch, France.
Nevers
M C
MC
Creminon
C
C
Mioskowski
C
C
Grassi
J
J
Lebeau
L
L
D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000378:metabolism; D007124:Immunoenzyme Techniques / Q000379:methods; D010766:Phosphorylation; D011817:Rabbits; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism
D019380:Anti-HIV Agents; D015215:Zidovudine