title: [High-dose chemotherapy and hematopoietic stem cell transplant in the treatment of advanced neuroblastoma].
abstract: Encouraging results have been reported with high-dose chemotherapy followed by hematopoietic stem cell transplant in the treatment of advanced neuroblastoma. However, relapse remains a significant problem. Since 1991, the stratification of patients with advanced neuroblastoma into different therapeutic regimens based on N-myc amplification has been carried out in Japan. To evaluate the advantage of the use of hematopoietic stem cell transplant in the treatment strategy, randomized clinical studies should be conducted to compare such treatment with conventional chemotherapy.
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mugishima
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic