The role of intrahepatic gammadelta-T cells for liver injury induced by Salmonella infection in mouse.
Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-delta knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (UC7-13D5) to stimulate gammadelta-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that gammadelta-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.
Ishigami
M
M
Research Institute for Disease Mechanism and Control, and Third Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan.
Nishimura
H
H
Yoshioka
K
K
Kakumu
S
S
Yoshikai
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019676:Genes, T-Cell Receptor delta / Q000235:genetics*; D007371:Interferon-gamma / Q000096:biosynthesis; D008099:Liver / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D012475:Salmonella / Q000254:growth & development; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta; D007371:Interferon-gamma; D000410:Alanine Transaminase