[The effect of enalapril maleate on the lipid peroxidation processes and on the body's antioxidant system in patients with hypertension].
Overall, forty-five patients with essential hypertension (EH) were examined. EH patients revealed dysbalance between lipid peroxidation and the antioxidant system. These disorders were found to correlate, to a certain extent, with severity of the malady, and to affect the character of the course of the process. Enalapril in a dose of 2.5 to 20 mg for 15 days, along with its hypotensive effect, has an antioxidant action on the metabolic processes at the expense of increase in the activity of enzymes of the antioxidant defense, such as catalase and peroxidase, which fact leads to augmentation of the antiperoxidative potential and prevention of further EH progression.
Shapovalova
S A
SA
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D002908:Chronic Disease; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000975:Antioxidants; D004656:Enalapril
Vliianie énalaprila maleata na protsessy lipoperoksidatsii i antioksidantnoĭ sistemy organizma u bol'nykh gipertonicheskoĭ bolezn'iu.