title: Trace metal excretion in patients with homozygous hypercholesterolaemia.
abstract: In patients with familial hypercholesterolaemia regular therapeutic apheresis is acknowledged to have long-term benefit. A previously unrecognised complication of such intervention is the development of anaemia that reflects a sub-optimal dietary iron intake coupled with accelerated loss of this trace metal in the fluid discarded after each procedure. Additional contributions result from enhanced urinary excretion as a result of chelation to citrate used as an anticoagulant and frequent blood sampling. The underlying pathophysiologic process appears to be reduced deformability. We now document similar and significant losses of zinc, copper and chromium in these circumstances. In the case of the latter three elements, no associated clinical syndromes have thus far been identified, probably because deficiency states are less well-recognised than that due to iron loss and, additionally, because critical reductions are avoided by their replenishment during a normal food intake. These studies are, nevertheless, relevant since they are the basis for recommending prophylactic supplementation during this form of management.
authors.affiliation: Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
authors.forename: G E
authors.initials: GE
authors.lastname: Jackson
authors.forename: R
authors.initials: R
authors.lastname: Blewet
authors.forename: A L
authors.initials: AL
authors.lastname: Rodgers
authors.forename: L
authors.initials: L
authors.lastname: Wood
authors.forename: P
authors.initials: P
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000328:Adult; D000925:Anticoagulants; D002857:Chromium / Q000652:urine; D019343:Citric Acid / Q000097:blood; D003198:Computer Simulation; D003300:Copper / Q000097:blood; D005260:Female; D006720:Homozygote; D006801:Humans; D006937:Hypercholesterolemia / Q000235:genetics* / Q000628:therapy / Q000652:urine*; D007501:Iron / Q000097:blood / Q000652:urine; D008297:Male; D010956:Plasmapheresis / Q000009:adverse effects; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism; D014131:Trace Elements / Q000097:blood / Q000652:urine*; D015032:Zinc / Q000097:blood / Q000652:urine
chemical_list: D000925:Anticoagulants; D012709:Serum Albumin; D014131:Trace Elements; D002857:Chromium; D019343:Citric Acid; D003300:Copper; D007501:Iron; D015032:Zinc