[Advances in the research on repairing cartilaginous defects of synovial joint].
The repair of defects of articular cartilage has continued to be a difficult problem. This article provided a collective review from literature pertaining to the advances gained in the repair of cartilaginous defects. In the spontaneous repair, if the defect of the cartilage was less than 3 mm, might result in complete or partial repair, but in those the diameter was more than 3 mm, the defect could not be repaired by normal cartilage. Although the cartilaginous autograft could give good result, but it could not be widely applied because short of supply of the autogenous cartilage. Cartilagious allograft could not be taken to repair cartilaginous defect because of reaction from tissue rejection. The transplantation of periosteal or perichondral graft had been tried but was eventually abandoned because of poor long-term result. The transplantation of free chondrocytes might be a method of hope. In general, transplantation of free chondrocytes into the cartilaginous defect will be lost. The supply of autogenous chondrocytes was very limited, and the heterogenous chondrocytes would inflict immunoreaction after being transplanted. In late of 1980, a new concept of tissue engineering was proposed. The problem that a scaffold of appropriate material which could hold the free chondrocytes in place from being lost might undergo proliferation and differentiation into new cartilage was far from being solved. Although tissue engineering still had various problems needed further investigation, but it will probably be the main direction of development in this field.
Chen
F
F
Shanghai Tissue Engineering Laboratory, P.R. China.
Chao
Y
Y
Shang
Q
Q
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000637:transplantation*; D002358:Cartilage, Articular / Q000293:injuries* / Q000601:surgery; D017690:Cell Transplantation; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible; D006801:Humans; D010521:Periosteum / Q000637:transplantation
D020099:Coated Materials, Biocompatible