title: Longitudinal, transverse, and diffuse nail hyperpigmentation induced by hydroxyurea.
abstract: Hydroxyurea is a cytostatic agent used in patients with myeloproliferative disorders that may produce nail hyperpigmentation, most frequently longitudinal melanonychia. We present a patient treated with hydroxyurea whose nails showed several patterns of nail hyperpigmentation, including longitudinal and transverse bands, and a diffuse darkening of the nail matrix.
authors.affiliation: Fundación Hospital Alcordón, Fundación Hospital Verin, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Martín
authors.forename: S
authors.initials: S
authors.lastname: Ros-Forteza
authors.forename: P
authors.initials: P
authors.lastname: de Unamuno
mesh_terms: D000368:Aged; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D017495:Hyperpigmentation / Q000139:chemically induced*; D008297:Male; D009260:Nail Diseases / Q000139:chemically induced*; D013921:Thrombocytopenia / Q000188:drug therapy
chemical_list: D006918:Hydroxyurea