title: Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: D
authors.initials: D
authors.lastname: Bom
authors.forename: D P
authors.initials: DP
authors.lastname: Curran
authors.forename: A J
authors.initials: AJ
authors.lastname: Chavan
authors.forename: S
authors.initials: S
authors.lastname: Kruszewski
authors.forename: S G
authors.initials: SG
authors.lastname: Zimmer
authors.forename: K A
authors.initials: KA
authors.lastname: Fraley
authors.forename: T G
authors.initials: TG
authors.lastname: Burke
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005454:Fluorescence Polarization; D006801:Humans; D006868:Hydrolysis; D010715:Phosphatidylglycerols / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D010715:Phosphatidylglycerols; D059004:Topoisomerase I Inhibitors; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine; D002166:Camptothecin