title: [Localized Castleman's disease associated with high-grade lymphoma].
abstract: Castleman's disease is a rare entity which is characterized by its histologic features: hyperplasia of lymph nodes and capillary proliferation. Two distinct histological patterns has been described: hyaline vascular type and plasma-cell type. Two different clinical course has been identified. While localized type is usually a benign disease in which surgical resection is curative, multicentric type has a poor prognosis regarded to the appearance of severe infection or neoplasm (Kaposi's sarcoma or malignant lymphoma. We present a rare association of localized Castleman's disease that presents synchronously with a diffuse large-cell lymphoma.
authors.affiliation: Servicio de Medicina Interna (Departamento de Medicina), Hospital Universitario 12 de Octubre, Madrid.
authors.forename: R M
authors.initials: RM
authors.lastname: Sanz García
authors.forename: J M
authors.initials: JM
authors.lastname: Guerra Vales
authors.forename: I
authors.initials: I
authors.lastname: de Prada
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez
authors.forename: V
authors.initials: V
authors.lastname: Guillén Camargo
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Enfermedad de Castleman localizada asociada a linfoma de alto grado.