Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle.
Preclinical and clinical studies suggest that females may be less vulnerable to cocaine's toxic effects than males. The pharmacokinetics of intravenous cocaine (0.2 and 0.4 mg/kg) were measured in 12 men and 22 women with a history of cocaine abuse, matched with respect to age and body mass index (BMI). Women were studied during the follicular and the luteal phases of the menstrual cycle. There were no differences between men and women in pharmacokinetic measures [peak plasma cocaine levels (Cmax), elimination half-life (T 1/2 min), area under the curve (AUC)] or cardiovascular or subjective effects "high" measures. Heart rate increases were cocaine dose-related (p < .01-.02) and also did not differ between men and women. Cocaine's pharmacokinetic and pharmacodynamic effects were similar in men and women, and in women during the follicular and mid-luteal phases of the menstrual cycle.
Mendelson
J H
JH
Alcohol and Drug Abuse Research Center, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA.
Mello
N K
NK
Sholar
M B
MB
Siegel
A J
AJ
Kaufman
M J
MJ
Levin
J M
JM
Renshaw
P F
PF
Cohen
B M
BM
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D015992:Body Mass Index; D003042:Cocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019970:Cocaine-Related Disorders / Q000534:rehabilitation; D004958:Estradiol / Q000097:blood; D005260:Female; D005498:Follicular Phase / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008183:Luteal Phase / Q000502:physiology*; D008297:Male; D011374:Progesterone / Q000097:blood; D012016:Reference Values; D012044:Regression Analysis; D012727:Sex Characteristics
D011374:Progesterone; D004958:Estradiol; D003042:Cocaine