title: A genetic basis for atrophy: dominant non-responsiveness and helicobacter induced gastritis in F(1) hybrid mice.
abstract: BACKGROUND
  The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free.
  
  
  OBJECTIVE
  To investigate these host factors further by using genetic crosses of responder and non-responder mice.
  
  
  METHODS
  F(1) hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected for three months with H felis. Gastritis was assessed by histopathology and serum antibody responses by ELISA.
  
  
  RESULTS
  Infection of CBA/Ca mice and F(1) hybrids induced little or no gastritis. Analyses of the antibody responses in these mice revealed virtually undetectable anti-helicobacter antibody levels despite colonisation with high numbers of H felis. In contrast, infection of H felis responsive strains induced gastritis and a significant humoral immune response.
  
  
  CONCLUSIONS
  The non-responsiveness of CBA/Ca mice to H felis infection is dominantly inherited. The lack of gastritis in CBA mice and their offspring is probably due to active suppression of the immune response normally mounted against H felis. Investigation of these mechanisms will provide important insights relevant to induction of gastric atrophy and cancer in humans.
authors.affiliation: School of Microbiology and Immunology, University of New South Wales, Sydney, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Sutton
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: R
authors.initials: R
authors.lastname: Genta
authors.forename: D
authors.initials: D
authors.lastname: Torrey
authors.forename: A
authors.initials: A
authors.lastname: Savinainen
authors.forename: J
authors.initials: J
authors.lastname: Pappo
authors.forename: A
authors.initials: A
authors.lastname: Lee
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D005757:Gastritis, Atrophic / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D020022:Genetic Predisposition to Disease; D016998:Helicobacter / Q000276:immunology; D016481:Helicobacter Infections / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity
chemical_list: D000907:Antibodies, Bacterial