title: Effects of age and manganese (II) chloride on peroxidase activity of brain and liver of the teleost, Channa punctatus.
abstract: Fish provide enormous spectrum of longevity and thus present the possibility of multiple mechanisms of senescence. Oxidative stress as a causative agent of senescence and the protective role of antioxidant enzymes were tested in the teleost, Channa punctatus taking peroxidase (POD) (EC 1.1 1.1.7) as the representative enzyme. The activity of POD in brain and liver declined during maturation phase (young vs middle-aged). During senescence phase (middle-aged to old) the enzyme activity increased in liver but remained stabilized in brain. The degree of increase in peroxidase activity following in vitro MnCl2 treatment was always higher in liver than in brain. The rate of MnCl2 induced increase in POD activity of both tissues showed an increasing trend with age. However statistical significance was observed only in brain during senescence phase. No significant loss of enzyme activity in both the tissues and greater degree of increase by MnCl2 in brain suggest that antioxidant capacity is not impaired in old murrels.
authors.affiliation: Government Science College, Chatrapur, Orissa, India.
authors.forename: S B
authors.initials: SB
authors.lastname: Nayak
authors.forename: B S
authors.initials: BS
authors.lastname: Jena
authors.forename: B K
authors.initials: BK
authors.lastname: Patnaik
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002712:Chlorides / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008136:Longevity; D008297:Male; D017895:Manganese Compounds / Q000494:pharmacology; D018384:Oxidative Stress; D010473:Perciformes / Q000378:metabolism*; D009195:Peroxidase / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D002712:Chlorides; D017895:Manganese Compounds; D009195:Peroxidase; C025340:manganese chloride