[The role of fetus decalcified bone matrix (FDBM) in inducing pure titanium-bone implant integration].
Because of its high biological compatibility, titanium has been a good biomaterial. The implanted artificial bone made from titanium can contact with the vital and mature osseous tissue directly within 3-6 months, the so-called osteointergration. In order to promote the process of osteointergration, FDBM of rabbit was prepared and was combined with pure titanium so as to speed up osteointergration. The study focused on bone density, bone intergration rate, new bone growth rate around the pure titanium, and the Ca2+ and PO(4)3- density of titanium-bone interface. A control group of pure titanium inplant without FDBM was set up. The results showed FDBM had no antigenicity. It could induce and speed up the new bone formation at titanium-bone interface. The titanium-bone intergration time was within 2 months. It was suggested that there were more bone morphogenesis protein (BMP) or other bone induction and bone formation factors in brephobone than that in child and adult bone. As a kind of bone induction material, FDBM was easy prepared, cheap in price, easy to storage, no antigenicity and obvious bone-inductive function.
Zou
L
L
9th Affiliated People's Hospital, Shanghai Second Medical University, P.R. China.
Zhang
D
D
Wang
W
W
D000818:Animals; D001857:Bone Matrix / Q000196:embryology / Q000637:transplantation*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D020007:Implants, Experimental; D019919:Prosthesis Implantation / Q000379:methods; D011817:Rabbits; D013977:Tibia / Q000293:injuries / Q000378:metabolism / Q000601:surgery*; D014025:Titanium
D019485:Bone Morphogenetic Proteins; D014025:Titanium