Results of two European interlaboratory studies for the determination of beta-agonists in various matrices.
Two Beta-Agonist Interlaboratory Studies, 5/96 and 11/97, were designed and evaluated according to the International Harmonised Protocol for the Proficiency Testing of (Chemical) Analytical Laboratories (ISO/REMCO N 280) jointly elaborated by ISO, IUPAC and AOAC. In the sense of proficiency testing, interlaboratory studies are part of external quality assurance systems. The Beta-Agonist Interlaboratory Studies 5/96 and 11/97 were intended to offer laboratories in the EU Member States an opportunity to check objectively their routine methods for the detection of beta-agonists and to demonstrate the reliability of their analytical results; 48 and 44 laboratories, respectively, all involved in official residue control, participated in the studies. Irrespective of the large number of satisfactory results achieved at higher concentration levels according to the z-score evaluation, the number of false negative results is still unsatisfactory. The results of both Beta-Agonist Interlaboratory Studies confirmed that comparability of analytical results is not yet ensured within the European residue control system.
Wolf
C
C
EU Reference Laboratory for Residues of Veterinary Drugs, Federal Institute for Health Protection of Consumers and Veterinary Medicine, Berlin, Germany.
Behrendt
D
D
Conradi
B
B
Jülicher
B
B
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D000818:Animals; D002417:Cattle; D002623:Chemistry Techniques, Analytical; D004350:Drug Residues / Q000032:analysis*; D005062:European Union; D005506:Food Contamination / Q000032:analysis* / Q000331:legislation & jurisprudence; D007753:Laboratories; D008099:Liver / Q000737:chemistry; D015980:Public Health Practice; D011786:Quality Control; D019155:Veterinary Drugs / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood
D000318:Adrenergic beta-Agonists; D019155:Veterinary Drugs