title: Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate.
abstract: Major histocompatabilty (MHC) proteins rely heavily on peptide backbone recognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding.
authors.affiliation: Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: A B
authors.initials: AB
authors.lastname: Jones
authors.forename: J J
authors.initials: JJ
authors.lastname: Acton
authors.forename: M N
authors.initials: MN
authors.lastname: Rivetna
authors.forename: R T
authors.initials: RT
authors.lastname: Cummings
authors.forename: R M
authors.initials: RM
authors.lastname: Cubbon
authors.forename: E A
authors.initials: EA
authors.lastname: Nichols
authors.forename: C D
authors.initials: CD
authors.lastname: Schwartz
authors.forename: L S
authors.initials: LS
authors.lastname: Wicker
authors.forename: J D
authors.initials: JD
authors.lastname: Hermes
mesh_terms: D001665:Binding Sites; D015798:HLA-DR1 Antigen / Q000187:drug effects / Q000378:metabolism; D006388:Hemagglutinins / Q000737:chemistry; D000949:Histocompatibility Antigens Class II / Q000187:drug effects* / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D007769:Lactams / Q000737:chemistry; D008024:Ligands; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D010750:Phosphoproteins / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000187:drug effects / Q000378:metabolism
chemical_list: D015798:HLA-DR1 Antigen; D006388:Hemagglutinins; D000949:Histocompatibility Antigens Class II; D007769:Lactams; D008024:Ligands; D010455:Peptides; D010750:Phosphoproteins; D014157:Transcription Factors; C075995:down-regulator of transcription 1