title: Comparison of lung function in infants exposed to maternal smoking and in infants with a family history of asthma.
abstract: OBJECTIVE
  To compare lung function in infants exposed to maternal smoking with lung function in infants with a family history of asthma. There are no published studies comparing lung function in both groups.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  A tertiary pulmonary care center at a children's hospital.
  
  
  METHODS
  One hundred five infants with daily wheezing. Thirty-five infants had persistent exposure to maternal smoking, and 70 had a family history of asthma in parents or siblings.
  
  
  METHODS
  Infant pulmonary function tests were compared between the two groups. The ratio of terminal to peak expiratory flow at tidal breathing at 25% of the previous expiration remaining and the ratio of terminal to peak expiratory flow with forced expiration at 25% of the previous expiration remaining (FEF25/PFEF) were used to evaluate peripheral airflow. A > 25% improvement in FEF25/PFEF after a bronchodilator challenge test was considered a positive response.
  
  
  RESULTS
  Most infants in both groups had evidence of peripheral airflow obstruction with forced expiration. In infants exposed to maternal smoking, only 4 of 35 (11.4%) responded to a bronchodilator, compared to 51 of 70 (72.9%) in the group with a family history of asthma (p < 0.0005). There was no statistically significant difference in total respiratory system compliance, total respiratory system resistance, tidal volume, and degree of peripheral airflow obstruction at tidal breathing or after forced expiration in both groups.
  
  
  CONCLUSIONS
  Infants with exposure to maternal smoking and infants with a family history of asthma have altered lung function, and a positive response to a bronchodilator is one variable that seems to differentiate the two groups.
authors.affiliation: Department of Pediatrics, University of Louisville, KY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sheikh
authors.forename: L J
authors.initials: LJ
authors.lastname: Goldsmith
authors.forename: L
authors.initials: L
authors.lastname: Howell
authors.forename: L
authors.initials: L
authors.lastname: Parry
authors.forename: N
authors.initials: N
authors.lastname: Eid
mesh_terms: D000403:Airway Resistance; D001249:Asthma / Q000235:genetics*; D001985:Bronchial Provocation Tests; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D012129:Respiratory Function Tests; D012135:Respiratory Sounds / Q000503:physiopathology*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution