title: Genome-based structural biology.
abstract: Spectacular achievements in whole genome sequencing open up new possibilities for structural research. Protein structures can now be studied in their natural genomic context. On the other hand, structure prediction algorithms can be improved using species-specific tendencies in folding patterns. Finally, efficient strategies to select targets for structure determination can be devised. In this review we consider new computational approaches and results in protein structure analysis stemming from the availability of complete genomes.
authors.affiliation: GSF-Forschungszentrum fuer Umwelt und Gesundheit, Munich Information Center for Protein Sequences, am Max-Planck-Institut für Biochemie, Martinsried, Germany. frishman@mips.biochem.mpg.de
authors.forename: D
authors.initials: D
authors.lastname: Frishman
authors.forename: H W
authors.initials: HW
authors.lastname: Mewes
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000235:genetics; D005658:Fungi / Q000235:genetics; D020407:Internet; D008958:Models, Molecular; D015394:Molecular Structure; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D017421:Sequence Analysis
chemical_list: D011506:Proteins