title: [Urine C-peptide excretion in hypocaloric states and factors affecting its excretion].
abstract: Recent evidence suggests that hyperinsulinemia may contribute to the development of various risk factors of atherosclerosis. To examine the effects of energy intake on insulin secretion, 24-h urine C-peptide was measured in twelve women with rheumatoid arthritis who were not taking any medicine and stayed in Koda hospital for a diet therapy which lasted 55 days. They were basically placed on a 1200 kcal/day vegan diet combined with three 3-5-day fasting periods (200 kcal/day). Urine C-peptide excretion markedly decreased from 31-40 to 8-14 micrograms/day during the fasting periods. Among the anthropometric variables examined, the average level of urine C-peptide excretions measured in the fasting periods showed a significant correlation with the percentage and the amount of body fat. However, such correlation was not observed while the calorie intake was 1200 kcal. No clinical laboratory parameter showed a significant correlation with urinary C-peptide excretion. These results suggest that the major determinant of urine C-peptide excretion is food intake and that hyperinsulinemia could be easily improved by restricting energy intake.
authors.affiliation: Department of Clinical Laboratory Medicine, University of Tokyo Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Futamura
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: S
authors.initials: S
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Aihara
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Koda
authors.forename: K
authors.initials: K
authors.lastname: Nakahara
mesh_terms: D001172:Arthritis, Rheumatoid / Q000178:diet therapy; D002096:C-Peptide / Q000652:urine*; D002149:Energy Intake; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000178:diet therapy
chemical_list: D002096:C-Peptide