title: Serum mucin antigen (CASA) as a marker of amiodarone-induced pulmonary toxicity.
abstract: Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity.
authors.affiliation: Department of Obstetrics & Gynaecology, University of Queensland, Brisbane, Australia.
authors.forename: P L
authors.initials: PL
authors.lastname: Devine
authors.forename: W J
authors.initials: WJ
authors.lastname: Siebert
authors.forename: S L
authors.initials: SL
authors.lastname: Morton
authors.forename: B
authors.initials: B
authors.lastname: Scells
authors.forename: R J
authors.initials: RJ
authors.lastname: Quin
authors.forename: W F
authors.initials: WF
authors.lastname: Heddle
authors.forename: P V
authors.initials: PV
authors.lastname: Zimmerman
authors.forename: P J
authors.initials: PJ
authors.lastname: Donohoe
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000097:blood; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000097:blood; D006334:Heart Function Tests; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000175:diagnosis*; D018396:Mucin-1 / Q000097:blood*; D011659:Pulmonary Gas Exchange
chemical_list: D000889:Anti-Arrhythmia Agents; D018396:Mucin-1; D000638:Amiodarone