title: Upper gut dysmotility in slow-transit constipation: is it evidence for a pan-enteric neurological deficit in severe slow transit constipation?
abstract: Although constipation is common only a small fraction meet the criteria of slow transit constipation. Those that do are resistant to treatment and present a significant clinical problem to the physician and surgeon. Evidence has been accumulating over many years that the impaired colonic motility is part of a generalized motility defect. There are several reports of oesophageal dysmotility, delayed gastric emptying and slow small bowel transit. These abnormalities are not secondary to a distended colon since they are still seen after colonic cleansing and even after colectomy. The manometric abnormalities of small bowel motility are hard to assess unless done over a prolonged period (24 h) because of the great variability observed. The clinical picture of slow transit constipation is quite different from chronic intestinal pseudo-obstruction and the manometric abnormalities are much less obvious. The possibility of an underlying autonomic disturbance warrants further study.
authors.affiliation: Division of Gastroenterology, University Hospital, Nottingham, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Spiller
mesh_terms: D003106:Colon / Q000294:innervation*; D003248:Constipation / Q000473:pathology / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D005772:Gastrointestinal Transit; D006801:Humans; D008365:Manometry; D016065:Myoelectric Complex, Migrating; D013997:Time Factors