title: Somatostatin receptor imaging and therapy of pancreatic endocrine tumors.
abstract: Somatostatin receptors (SS-Rs) have been found on a variety of neuroendocrine tumors like carcinoids, paragangliomas, as well as on brain and breast tumors. SS-Rs are also present on most pancreatic endocrine tumors, while previous in vitro studies indicate the absence of these receptors on pancreatic duct cancers. Somatostatin receptor scintigraphy with a radionuclide labeled somatostatin analogue, [111In-DTPA0]-octreotide, is a sensitive and specific technique to visualize in vivo the presence of SS-Rs on various tumors. The purpose of this article is to review the somatostatin receptor imaging of pancreatic endocrine tumors and to illustrate the impact of SS-R expression for therapeutic strategies.
authors.affiliation: Department of Surgery, Erasmus Medical Center Rotterdam, The Netherlands. vaneijck@hlkd.azr.nl
authors.forename: C H
authors.initials: CH
authors.lastname: van Eijck
authors.forename: M
authors.initials: M
authors.lastname: de Jong
authors.forename: W A
authors.initials: WA
authors.lastname: Breeman
authors.forename: G D
authors.initials: GD
authors.lastname: Slooter
authors.forename: R L
authors.initials: RL
authors.lastname: Marquet
authors.forename: E P
authors.initials: EP
authors.lastname: Krenning
mesh_terms: D001079:Apudoma / Q000737:chemistry / Q000532:radiotherapy*; D006801:Humans; D007205:Indium Radioisotopes / Q000627:therapeutic use; D015282:Octreotide / Q000378:metabolism / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000532:radiotherapy*; D004369:Pentetic Acid; D017481:Receptors, Somatostatin / Q000032:analysis*
chemical_list: D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; D004369:Pentetic Acid; D015282:Octreotide