Psychotropics and suicide prevention. Implications from toxicological screening of 5281 suicides in Sweden 1992-1994.
BACKGROUND
Systematic clinical investigations of consecutive suicides have found psychiatric disorders in 90-95% of subjects (depressive disorder 30-87%).


OBJECTIVE
To investigate use of psychotropics in men and women of different ages who commit suicide.


METHODS
Results of toxicological screening in 5281 suicides in Sweden 1992-94 were studied.


RESULTS
Psychotropics were detected in 45.3% of the suicides. Antidepressants were detected in 12.4% of the men and 26.2% of the women (7.2% and 14.2%, respectively, of those under 30 years of age). Neuroleptics or antiepileptics (in the absence of antidepressants) were detected in 8.3%, and anxiolytics/hypnotics alone in 20.5% of the subjects. Overdose by an antidepressant was the probable cause of death in 2.1% of the men and 7.9% of the women.


CONCLUSIONS
The pattern of psychotropics detected in toxicology was incongruent with the pattern of diagnoses found in the clinical investigations of suicides mentioned above. Depression appears to be under treated in individuals committing suicide, especially in men and in subjects under 30 years of age.
Isacsson
G
G
Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Sweden. Goran.Isacsson@cnsf.ki.se
Holmgren
P
P
Druid
H
H
Bergman
U
U
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000506:poisoning; D000927:Anticonvulsants / Q000506:poisoning; D000928:Antidepressive Agents / Q000506:poisoning; D014150:Antipsychotic Agents / Q000506:poisoning; D062787:Drug Overdose / Q000453:epidemiology; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000506:poisoning*; D013548:Sweden / Q000453:epidemiology; D000092864:Suicide Prevention
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs