title: Giant juvenile xanthogranuloma of the tongue.
abstract: Juvenile xanthogranulomas (JXGs) are rare, benign, fibrohistiocytic lesions. They usually appear as one or more cutaneous papules on the head, neck, or trunk in infants. Twelve cases of oral JXGs have been reported, four of which involved the tongue. We present a 6-year-old girl with a large tongue mass diagnosed as JXG after an excisional biopsy. Histological and immunohistochemical staining results are presented. This is the first reported case of a giant oral JXG. A review of the literature on these unusual lesions is presented, along with discussion of their differential diagnosis and key aspects of the patient's evaluation, management, and pathological diagnosis.
authors.affiliation: Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: N L
authors.initials: NL
authors.lastname: Shapiro
authors.forename: D J
authors.initials: DJ
authors.lastname: Malis
authors.forename: C C
authors.initials: CC
authors.lastname: Charon
authors.forename: G F
authors.initials: GF
authors.lastname: Billman
authors.forename: D B
authors.initials: DB
authors.lastname: Kearns
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D009626:Terminology as Topic; D014057:Tomography, X-Ray Computed; D014060:Tongue Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014972:Xanthogranuloma, Juvenile / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery