Allelic frequencies of six (CA)n microsatellite markers of the dystrophin gene in the Korean population.
Using the polymerase chain reaction, we examined the allele frequencies and heterozygosities of six (CA)n markers of the dystrophin gene in Koreans. Allele frequencies of these markers were different from those reported for Caucasians. The heterozygosity values for these markers range from 29 to 86%. With the exception of the STR50 marker, these values were lower than those of Caucasians. However, all markers except for the 3'CA marker showed PIC values over 0.5, suggesting a high degree of polymorphism. Therefore, this study will be useful in linkage analysis for Duchenne and Becker muscular dystrophy families in the Korean population.
Kim
U K
UK
Department of Molecular Biology, Seoul National University, Seoul, Korea.
Cho
M S
MS
Chae
J J
JJ
Kim
S H
SH
Hong
S S
SS
Lee
S H
SH
Namkoong
Y
Y
Lee
C C
CC
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016189:Dystrophin / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D007723:Korea; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009136:Muscular Dystrophies / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods
D016189:Dystrophin