Vaccination against Taenia solium cysticercosis in pigs using native and recombinant oncosphere antigens.
Pigs were immunised with antigens derived from Taenia solium oncospheres or with a pool of three recombinant antigens from Taenia ovis, and subsequently challenged with T. solium eggs. The native oncosphere antigens induced 83% protection against viable, and 89% protection against the total number of cysticerci established following the challenge infection. Immunisation with the recombinant T. ovis antigens induced 93% protection against the establishment of viable cysticerci, and 74% protection against the total number of cysticerci. These results, and those achieved elsewhere with Taenia saginata and T. ovis, support the possibility of developing a practical vaccine to assist in the control of transmission of T. solium through pigs.
Plancarte
A
A
Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM, D.F., Mexico.
Flisser
A
A
Gauci
C G
CG
Lightowlers
M W
MW
D000818:Animals; D000947:Antigens, Helminth / Q000627:therapeutic use*; D003551:Cysticercosis / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D003552:Cysticercus / Q000276:immunology / Q000302:isolation & purification; D009132:Muscles / Q000469:parasitology; D011994:Recombinant Proteins / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000517:prevention & control*; D013621:Taenia / Q000276:immunology; D014611:Vaccination / Q000662:veterinary*; D014614:Vaccines, Synthetic / Q000627:therapeutic use*
D000947:Antigens, Helminth; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic