A longitudinal study of sero-reactivity to Plasmodium falciparum antigen in children and adult living in an endemic area of U.P.
Antibody levels of Pf RESA derived peptide R1 (EENVEHDA-C) from individuals living in malaria endemic areas correlated well with levels of endemicity. Serological and parasitological investigations were done in 32 adults (> 20 yrs) and 35 children (2-5 yrs) for three years; i.e. from 1992-95 periodically in village Piyawoli, U.P. Antibody levels against R1 peptide was estimated by ELISA, and blood smear for P. falciparum and P. vivax were screened using Jaswant Singh-Bhattacharya (JSB) staining. It appeared from our investigations that anti-R1 antibodies had a short span of life, i.e. 6-9 months. The longevity of these antibodies do not differ much in adults and children. The studies do not indicate any protective role for these antibodies. However, the levels of anti-R1 antibodies in a population living under malariogenic condition are related to Pf malaria endemicity.
Roy
A
A
Malaria Research Centre, Delhi, India.
Ansari
M A
MA
Kabilan
L
L
D000328:Adult; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002675:Child, Preschool; D019353:Endemic Diseases; D006801:Humans; D007194:India / Q000453:epidemiology; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology; D010455:Peptides / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*
D000953:Antigens, Protozoan; D010455:Peptides