title: Historical perspectives and current advancements in the bacteriology and medical therapy of struvite urinary stone disease.
abstract: Struvite calculi have afflicted man for thousands of years. Despite recent advances in surgical technology to treat these disabling stones, high recurrence rates and inability to remove all stone fragments remain significant problems. Previous non-surgical alternatives have been disappointing because of low success rates, increased side effects or poor tolerability. New research in this area continues to provide insight into origins of lithogenesis and non-invasive therapy for calculi caused by infection.
authors.affiliation: Clinical Instructor, Department of Urology, University of California at San Francisco School of Medicine, San Francisco, California, USA.
authors.forename: B F
authors.initials: BF
authors.lastname: Schwartz
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017616:Magnesium Compounds / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D000069877:Struvite; D014510:Urease / Q000037:antagonists & inhibitors; D014545:Urinary Calculi / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D000069877:Struvite; D014510:Urease