[Urine C-peptide excretion in hypocaloric states and factors affecting its excretion].
Recent evidence suggests that hyperinsulinemia may contribute to the development of various risk factors of atherosclerosis. To examine the effects of energy intake on insulin secretion, 24-h urine C-peptide was measured in twelve women with rheumatoid arthritis who were not taking any medicine and stayed in Koda hospital for a diet therapy which lasted 55 days. They were basically placed on a 1200 kcal/day vegan diet combined with three 3-5-day fasting periods (200 kcal/day). Urine C-peptide excretion markedly decreased from 31-40 to 8-14 micrograms/day during the fasting periods. Among the anthropometric variables examined, the average level of urine C-peptide excretions measured in the fasting periods showed a significant correlation with the percentage and the amount of body fat. However, such correlation was not observed while the calorie intake was 1200 kcal. No clinical laboratory parameter showed a significant correlation with urinary C-peptide excretion. These results suggest that the major determinant of urine C-peptide excretion is food intake and that hyperinsulinemia could be easily improved by restricting energy intake.
Futamura
A
A
Department of Clinical Laboratory Medicine, University of Tokyo Hospital.
Hashimoto
Y
Y
Okubo
S
S
Aihara
T
T
Watanabe
H
H
Fujita
A
A
Koda
M
M
Nakahara
K
K
D001172:Arthritis, Rheumatoid / Q000178:diet therapy; D002096:C-Peptide / Q000652:urine*; D002149:Energy Intake; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000178:diet therapy
D002096:C-Peptide