title: [The Berlipril and Retalzem treatment of hypertension patients: the dynamics of the clinico-hemodynamic indices and of the vasodilating humoral factors].
abstract: Submitted in the paper are data on clinical, hemodynamic, and neurohumoral effects of monotherapy with an inhibitor of the angiotensin-converting enzyme berlipril (enalapril maleate) and a calcium antagonist of the benzothiazepine series retalzem (diltiazem resinate) versus their combination therapy. The combination therapy offers a number of important advantages over monotherapy with the above-named agents, consisting in apparent hypotensive action and a greater activation of endothelium-derived vasodilating and antiaggregation substances.
authors.forename: S N
authors.initials: SN
authors.lastname: Koval'
authors.forename: T G
authors.initials: TG
authors.lastname: Starchenko
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Gorb
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Pen'kova
authors.forename: Kh D
authors.initials: KhD
authors.lastname: Khasanova
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D018377:Neurotransmitter Agents; D004656:Enalapril; D004110:Diltiazem
vernacular_title: Lechenie berliprilom i retalzemom bol'nykh gipertonicheskoĭ bolezn'iu: dinamika kliniko-gemodinamicheskikh pokazateleĭ i vazodilatiruiushchikh gumoral'nykh faktorov.