Structure and function of the P-type ATPases.
The P-type ATPases are integral membrane proteins that generate essential transmembrane ion gradients in virtually all living cells. The structures of two of these have recently been elucidated at a resolution of 8 A. When considered together with the large body of biochemical information that has accrued for these transporters and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by these proteins.
Scarborough
G A
GA
Department of Pharmacology, CB 7365 Mary Ellen Jones Building, University of North Carolina, Chapel Hill, NC 27599, USA. gas@med.unc.edu
D000818:Animals; D001692:Biological Transport; D000252:Calcium-Transporting ATPases / Q000737:chemistry / Q000502:physiology*; D003593:Cytoplasm; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
D006180:Proton-Translocating ATPases; D000252:Calcium-Transporting ATPases