Clinical efficacy of oxybutynin on sensory urgency as compared with that on motor urgency.
OBJECTIVE
Anticholinergic drug is widely accepted as an effective medication for frequency, urgency and urge incontinence related to detrusor overactivity (motor urgency). In order to elucidate whether anticholinergic drug is also effective for these symptoms related to bladder hypersensitivity (sensory urgency), clinical efficacy of oxybutynin on sensory urgency was compared with that on motor urgency.


METHODS
Twenty-four patients with sensory urgency, and 53 patients with motor urgency were treated with oxybutynin (6 mg/day) for 4 weeks and subjective and objective efficacies were evaluated. Subjective parameters were quantified with urge score (grade 0-3) and daily numbers of voiding and incontinence. Objective efficacies were evaluated with pre-/ postcomparison of cystometric parameters.


RESULTS
Excellent or good overall efficacy was obtained in 62.5% (15/24) of the sensory urgency group and 60.4% (32/53) of the motor urgency group. There was no statistical difference between these two groups. Objective cystometric parameters, bladder volume at first sensation and maximum cystometric capacity, statistically improved after the treatment in both groups.


CONCLUSIONS
The results suggest that oxybutynin works as well on sensory urgency as it does on motor urgency.
Hashimoto
K
K
Department of Urology, Kinki University School of Medicine, Osaka, Japan.
Ohnishi
N
N
Esa
A
A
Sugiyama
T
T
Park
Y
Y
Kurita
T
T
D000368:Aged; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D006801:Humans; D008333:Mandelic Acids / Q000627:therapeutic use*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D014549:Urinary Incontinence / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
D018680:Cholinergic Antagonists; D008333:Mandelic Acids; C005419:oxybutynin