The urinary excretion of deoxypyridinium cross-links is higher in diabetic than in nondiabetic adolescents.
We have measured the urinary excretion of deoxypyridinium (D-Pyr) crosslinks, a sensitive and specific marker of bone resorption, in morning urine in 102 healthy, nonhospitalized, Caucasian subjects (8-18 years) and in 18 diabetic subjects (12-17 years). The free D-Pyr crosslinks were measured using the Pyrilinks D-Assay. In the diabetic subjects, plasma glucose was regulated throughout the night by a constant infusion of insulin and a variable infusion of 24% glucose. In the nondiabetic subjects, the excretion of D-Pyr increased until 12-14 years of age, and thereafter decreased, and the excretion of D-Pyr/hour was correlated with the height Z-score. The excretion of D-Pyr/hour and the D-Pyr/creatinine ratio was higher in the diabetic adolescents than in the nondiabetic adolescents. In subjects over the age of 12, the D-pyr/creatinine ratio was higher in males than in females. In conclusion, in healthy children and adolescents, the excretion of D-Pyr peaks at 12-14 years of age. The D-Pyr excretion is higher in diabetic than in nondiabetic adolescents, suggesting increased bone resorption in diabetic adolescents.
Bjørgaas
M
M
Department of Clinical Chemistry, University Hospital of Trondheim, N-7006 Trondheim, Norway.
Haug
E
E
Johnsen
H J
HJ
D000293:Adolescent; D000596:Amino Acids / Q000652:urine*; D001786:Blood Glucose / Q000378:metabolism; D001862:Bone Resorption / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000652:urine*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D012016:Reference Values
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; C036020:deoxypyridinoline; D003404:Creatinine