5-Fluoro-1-(3,4-dideoxy-3-fluoro-6-0-trityl-beta-D-glycero-hex-3-eno- pyranos-2-ulosyl (uracil): anticancer agent.
1,2:5,6-Di-0-isopropylidene glucofuranose on mild oxidation, reduction, fluorination and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-alpha-D-glucopyranose. This was coupled with silylated 5 fluorouracil. The nucleoside was deacetylated and after several subsequent protection and deprotection and final oxidation afforded the title compound.
Ollapally
A P
AP
Department of Chemistry, Florida Agricultural and Mechanical University, Tallahassee 32307, USA.
Bennouna-Dorange
I
I
Whitaker
T L
TL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000473:pathology; D005472:Fluorouracil / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology
C120718:5-fluoro-1-(3,4-dideoxy-3-fluoro-6-O-trityl-glycero-hex-3-eno-pyranos-2-ulosyl); D000970:Antineoplastic Agents; D009005:Monosaccharides; D005472:Fluorouracil