[In vitro effect of 1,2-dihydro-3H-1,4-benzodiazepine-2-one derivatives on the platelet aggregation and lipid peroxidation in rats].
There were discovered the anti-aggregative properties of some psychotropic drugs as gidazepam, phenazepam and its derivatives 3-oxyphenazepam, esters of 3-oxyphenazepam, with IC50 values of 8.19-11 x 10(-4) M. On their anti-aggregative effects they exceed of the acetylsalicylic acid (IC50 = 21.3 x 10(-4) M). Only gidazepam, containing in its chemical structure hydrazide fragment, caused significant decrease in the content of MDA. The possibility of involvement of lipid peroxidation in mechanism of its anti-aggregative effect is discussed.
Karaseva
T L
TL
A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Odessa.
Belikova
M V
MV
Pavlovskiĭ
V I
VI
Andronati
K S
KS
Kabanova
T A
TA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats
D014151:Anti-Anxiety Agents; D010975:Platelet Aggregation Inhibitors; D001569:Benzodiazepines; C017928:phenazepam; D008315:Malondialdehyde; D001241:Aspirin; C077010:gidazepam
Vliianie in vitro proizvodnykh 1,2-digidro-3H-1,4-benzdiazepin-2-ona na agregatsiiu trombotsitov i peroksidnoe okislenie lipidov u krys.