L-purine nucleosides as selective antimalarials.
L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.
Gero
A M
AM
School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia.
Perrone
G
G
Brown
D M
DM
Hall
S T
ST
Chu
C K
CK
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000469:parasitology; D010963:Plasmodium falciparum / Q000201:enzymology; D011684:Purine Nucleosides / Q000493:pharmacokinetics / Q000494:pharmacology*
D000962:Antimalarials; D011684:Purine Nucleosides; D000243:Adenosine Deaminase