[A comparative study of the efficacy of pharmacological agents in regulating the level of NADPH in the hepatocytes in an acute lesion].
Experiments on mice with acute toxic damage to the liver induced by thioacetamide (200 mg/kg) demonstrated inhibited activity of enzymes glucose-6-phosphate dehydrogenase (G-6-PDH), NADPH-dependent isocitrate dehydrogenase and malate dehydrogenase in the hepatocyte mitochondrial and microsomal-cytosol fractions. Pharmacotherapy with membranostabilizers and cytochrome P-450 inducers activated the enzymes under study, the degree of activation depended on agents used.
Inoiatova
F Kh
FKh
Central Research Laboratory, Second Tashkent Medical Institute, Uzbekistan.
Khakimov
Z Z
ZZ
D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009249:NADP / Q000187:drug effects* / Q000378:metabolism; D013853:Thioacetamide / Q000633:toxicity; D013997:Time Factors
D000931:Antidotes; D013853:Thioacetamide; D009249:NADP
Sravnitel'noe izuchenie éffektivnosti nekotorykh farmakologicheskikh sredstv v reguliatsii urovnia NADFN v gepatotsitakh pri ikh ostrom porazhenii.