title: Stability of antibiotics used for antibiotic-lock treatment of infections of implantable venous devices (ports).
abstract: Antibiotic-lock is a treatment for catheter-related bloodstream infections in which a solution containing heparin and an antibiotic dwells in the lumen of the catheter or port. We tested the stability of vancomycin, cefazolin, ticarcillin-clavulanic acid, ceftazidime, or ciprofloxacin combined with heparin after incubation in vitro at 25 or 37 degrees C for intervals of up to 10 days by bioassay. All the antibiotic solutions except ceftazidime retained >/=90% activity at both 25 and 37 degrees C. Thus, studies of antibiotic-heparin lock solutions with dwell times of up to 10 days are feasible.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, Schneider Children's Hospital of Long Island Jewish Medical Center, New Hyde Park, New York 11040, USA.
authors.forename: T U
authors.initials: TU
authors.lastname: Anthony
authors.forename: L G
authors.initials: LG
authors.lastname: Rubin
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D000925:Anticoagulants / Q000008:administration & dosage / Q000737:chemistry*; D002408:Catheters, Indwelling / Q000009:adverse effects / Q000382:microbiology*; D004355:Drug Stability; D006493:Heparin / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012996:Solutions; D014640:Vancomycin / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D012996:Solutions; D014640:Vancomycin; D006493:Heparin