[The use of low doses of prednisolone for the treatment of patients with Duchenne-Becker myodystrophy].
A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed. Three-month cycles of prednisolone treatment alternated with three-month cycles of placebo during the year. Each patient received 0.5 mg/kg per day of treatment but with taking in account the alternate days, the daily dose diminished to 0.25 mg/kg/per day. 50 patients with Duchenne-Becker muscular dystrophy participated in this randomized double-blind controlled trial and up to now 3 of them were on the program about 1.5 year and 24 of them--about a year. Preliminary results show some beneficial effects in the absence of manifest side-effects.
Shakhovskaia
N I
NI
Shishkin
S S
SS
Skozobtseva
L F
LF
Shakhovskiĭ
V A
VA
Rodnikova
N I
NI
Lunga
I N
IN
Tarksh
M A
MA
Gerasimova
N L
NL
Krakhmaleva
I N
IN
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004576:Electromyography / Q000187:drug effects / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D009136:Muscular Dystrophies / Q000175:diagnosis / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage*; D013997:Time Factors
D005938:Glucocorticoids; D011239:Prednisolone
Primenenie malykh doz prednizolona dlia lecheniia bol'nykh miodistrofieĭ Diushenna--Bekkera.