Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis.
Shah
J H
JH
EntreMed, Inc., 9640 Medical Center Drive, Rockville, Maryland 20850, USA. jamsheds@entremed.com
Swartz
G M
GM
Papathanassiu
A E
AE
Treston
A M
AM
Fogler
W E
WE
Madsen
J W
JW
Green
S J
SJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005977:Glutarates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C120834:2-methyl-2-(1-oxoisoindol-2-yl)glutaric acid; D000970:Antineoplastic Agents; D005977:Glutarates; D007211:Indoles; D013792:Thalidomide