title: Effect of long-term noise exposure on the developing and developed ear in the Rat.
abstract: There have been reports that the developing ear is more sensitive than the adult ear to noise-induced hearing loss. This was investigated by testing auditory function in rats, both electrophysiologically and histologically, following exposure to broad-band noise (12 h/day for 15 days) at different stages of auditory development (neonates and adults), and also in age-matched controls. An exposure of 90 dB SPL broad-band noise caused no long-term change in auditory function in either age group. A higher exposure (102 dB SPL) caused greater long-term changes in hearing in the adult compared to the young noise-exposed rats, although histology showed greater damage to hair cells in the younger animals. Therefore, functionally, the developing ear does not seem more vulnerable than the developed ear to acoustic trauma.
authors.affiliation: Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. freeman@pob.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Freeman
authors.forename: R
authors.initials: R
authors.lastname: Khvoles
authors.forename: L
authors.initials: L
authors.lastname: Cherny
authors.forename: H
authors.initials: H
authors.lastname: Sohmer
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology; D000818:Animals; D004423:Ear / Q000254:growth & development*; D016057:Evoked Potentials, Auditory, Brain Stem; D006198:Hair Cells, Auditory / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000473:pathology; D009622:Noise / Q000009:adverse effects*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D051381:Rats / Q000502:physiology; D013997:Time Factors