Synthesis and testing of new modified nucleosides.
New efficient routes for the high-yielding synthesis of several classes of modified nucleosides have been developed. We have prepared both the D- and L-enantiomers of the methylene-expanded oxetanocin isonucleosides 1a-c and the L-2',3'-dideoxy isonucleosides 2abc (both the oxa and thia analogues) as well as new routes for the preparation of L-ribose and 2-deoxy L-ribose 3ab and their modified nucleosides 4.
Jung
M E
ME
Department of Chemistry and Biochemistry, University of California, Los Angeles 90095-1569, USA.
Nichols
C J
CJ
Kretschik
O
O
Xu
Y
Y
D006678:HIV / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D009705:Nucleosides