title: A case of soft tissue mesenchymal chondrosarcoma metastatic to skin, clinically mimicking keratoacanthoma.
abstract: We report the first case of metastatic involvement of the skin by a soft tissue mesenchymal chondrosarcoma (MS). A 64-year-old man presented 15 months after resection of a 7.0 cm MS from his left forearm with a rapidly growing, erythematous nodule on the left side of the upper lip. The lesion was clinically interpreted as a keratoacanthoma. The histologic appearance was identical to that of the soft tissue MS; an immunohistochemical stain for CD99 was positive. Lung and bone metastases were subsequently documented. Our case expands the differential diagnosis of malignancies with cartilaginous differentiation that can involve the skin.
authors.affiliation: Department of Pathology, Hospital Universitario de Getafe, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Aramburu-González
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Justo
authors.forename: J
authors.initials: J
authors.lastname: Jiménez-Reyes
authors.forename: C
authors.initials: C
authors.lastname: Santonja
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D018211:Chondrosarcoma, Mesenchymal / Q000737:chemistry / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D007636:Keratoacanthoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000737:chemistry / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules