title: Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients.
abstract: The present study aimed to investigate the prevalence and seasonal variation of hypovitaminosis D (defined as serum 25-hydroxyvitamin D level below 30 nmol/l) among healthy subjects and hospitalized patients living in central Italy. We studied 297 subjects, 131 in February 1997 and 166 in July 1997, subdivided into four groups: (a) young healthy blood donors; (b) healthy postmenopausal women; (c) inpatients with various medical diseases and (d) inpatients engaged in long-term rehabilitation programmes because of various neurological disorders. In all subjects and patients serum levels of 25-hydroxyvitamin D were measured by radioimmunoassay. We found a significant seasonal variation (P < 0.0001) of serum 25-hydroxyvitamin D levels, mean values being higher in summer in all groups, except in patients with a longer hospitalization time (group (d)). In each group, a significantly higher prevalence of hypovitaminosis D was found in winter compared with summer time (P < 0.001), being unexpectedly high in postmenopausal women (winter 32% and summer 4.5%); furthermore, in both seasons, inpatients were characterized by the highest incidences of hypovitaminosis, particularly those in group (d) (winter 82.3% and summer 57.8%). The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.
authors.affiliation: Ospedale San Giovanni Battista, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Romagnoli
authors.forename: P
authors.initials: P
authors.lastname: Caravella
authors.forename: L
authors.initials: L
authors.lastname: Scarnecchia
authors.forename: P
authors.initials: P
authors.lastname: Martinez
authors.forename: S
authors.initials: S
authors.lastname: Minisola
mesh_terms: D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006760:Hospitalization; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012621:Seasons; D014807:Vitamin D / Q000097:blood*; D014808:Vitamin D Deficiency / Q000453:epidemiology*
chemical_list: D014807:Vitamin D; D015652:25-Hydroxyvitamin D 2