title: Is the coexistence of mutations in the genes of factor V and MTHFR a predisposing factor for massive skin necrosis due to loxoscelism?
abstract: A 28-year-old previously healthy man was diagnosed as having an extensive necrotic lesion of his calf due to loxoscelism. One year later he was diagnosed as having co-inheritance of mutations in factor V and methyl tetrahydrofolate reductase (MTHFR). This is the first report of a possible etiologic connection between loxoscelism necrotic lesions and thrombogenic diseases.
authors.affiliation: Medical Corps, Israel Defense Forces, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Mandel
authors.forename: I
authors.initials: I
authors.lastname: Grotto
authors.forename: M
authors.initials: M
authors.lastname: Gdalevich
authors.forename: D
authors.initials: D
authors.lastname: Mimouni
authors.forename: I
authors.initials: I
authors.lastname: Ashkenazi
authors.forename: J
authors.initials: J
authors.lastname: Haviv
authors.forename: O
authors.initials: O
authors.lastname: Shpilberg
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D009336:Necrosis; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D012867:Skin / Q000473:pathology*; D001098:Spider Bites / Q000235:genetics* / Q000473:pathology
chemical_list: D005165:Factor V; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)