[Effect of homolymph on some elements of antioxidants in peripheral blood of lung cancer patients].
The influence of homolymph and of that incubated with chemopreparations on in vitro activity of antioxidants of blood was compared to establish a possible mechanism of effective application of homolymphochemotherapy for locally advanced tumors of the lung. As a result of homolymph injection into the blood, mainly non-enzymatic systems of antioxidant defense by lymphocytes were affected. This was probably due to their being disposed of in the course of host-against-transplant reaction to heterogenous antigens of donor lymph. Neutrophil functional activity was shown to pick up again as homolymph and chemotherapeutic drugs interacted with blood. A possible therapeutic effect of homolymph and chemopreparations on blood may be alleviating lung tumor suppression of granulocytes.
Sidorenko
Iu S
IuS
Research Institute of Oncology, Ministry of Health of the RF, Rostov-on-Don.
Frantsiiants
E M
EM
Musienko
N V
NV
Tkacheva
G N
GN
Shalashnaia
E V
EV
Kartashov
S Z
SZ
Kas'ian
E G
EG
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism*; D003131:Combined Modality Therapy; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007267:Injections; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D008196:Lymph / Q000276:immunology*; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology*; D014184:Transplantation, Homologous
D000975:Antioxidants
Vliianie gomolimfy na nekotorye zven'ia antiokislitel'noĭ zashchity perifericheskoĭ krovi bol'nykh rakom lëgkogo.