Inhibition of beta1-integrin expression reduces clone size during early retinogenesis.
We have used an antisense retrovirus strategy to test the role of beta1-integrin in the early period of clone development in the embryonic chick neural retina. Analyses of clone size and dispersion demonstrated a marked effect of reducing the levels of expressed beta1-integrin on this critical phase of retina cell and tissue development.
Skeith
A
A
The Whitney Laboratory, University of Florida, 9505 Ocean Shore Boulevard, Saint Augustine, FL 32086, USA.
Dunlop
L
L
Galileo
D S
DS
Linser
P J
PJ
D000818:Animals; D016375:Antisense Elements (Genetics); D002642:Chick Embryo; D002999:Clone Cells / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D019012:Integrin beta1 / Q000096:biosynthesis*; D012160:Retina / Q000196:embryology / Q000378:metabolism*; D012190:Retroviridae / Q000235:genetics
D016375:Antisense Elements (Genetics); D019012:Integrin beta1