[An experimental study on effect of atrial natriuretic peptide on intraocular pressure of white rabbits].
OBJECTIVE
To study the therapeutic effect of atrial natriuretic peptide (ANP) on glaucoma.


METHODS
Various doses of ANP were injected subconjunctivally in albino rabbits, and their effects on intraocular pressures (IOPs) were observed.


RESULTS
The IOPs were significantly decreased by the subconjunctival injection of 20, 30, 40 micrograms of ANP, and with a dose of 40 micrograms, the maximum effect of IOP lowering of 0.88-0.15 kPa maintaining for the longest time 7.5 hours was obtained. Generally, one hour after the injection, the maximum effect could be seen. A dose-effect relationship that is the degree of the reduction of IOP increasing with the dose increase of ANP could be observed.


CONCLUSIONS
This study indicates that ANP might play an effective therapeutic role in glaucoma.
Yang
L
L
Ophthalmology Department, 210 PLA Hospital, Dalian.
Guan
J
J
Gao
S
S
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits
D009320:Atrial Natriuretic Factor