Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome.
We performed serial measurements of plasma endothelin-1 and cytokine levels (interleukin-1, interleukin-6, and tumor necrosis factor-alpha) in 23 children with severe acute respiratory distress syndrome during their first 7 days of disease. We report plasma endothelin-1 and interleukin-6 levels are increased in patients with acute respiratory distress syndrome, and that plasma endothelin-1 levels are significantly greater early in the clinical course of nonsurvivors than survivors. We conclude that plasma endothelin-1 levels are markedly increased in children with severe acute respiratory distress syndrome and speculate that high levels may serve as an early marker of poor outcome.
Dobyns
E L
EL
The Pediatric Heart Lung Center, Section of Pediatric General Critical Care, Denver, Colorado 80218, USA.
Eells
P L
PL
Griebel
J L
JL
Abman
S H
SH
D015415:Biomarkers; D002675:Child, Preschool; D003120:Colorado / Q000453:epidemiology; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D011379:Prognosis; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015415:Biomarkers; D019332:Endothelin-1; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha