title: (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase.
authors.affiliation: Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901, USA. Thomas.Aicher@pharma.novartis.com
authors.forename: T D
authors.initials: TD
authors.lastname: Aicher
authors.forename: R C
authors.initials: RC
authors.lastname: Anderson
authors.forename: G R
authors.initials: GR
authors.lastname: Bebernitz
authors.forename: G M
authors.initials: GM
authors.lastname: Coppola
authors.forename: C F
authors.initials: CF
authors.lastname: Jewell
authors.forename: D C
authors.initials: DC
authors.lastname: Knorr
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: D M
authors.initials: DM
authors.lastname: Sperbeck
authors.forename: L J
authors.initials: LJ
authors.lastname: Brand
authors.forename: R J
authors.initials: RJ
authors.lastname: Strohschein
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: C C
authors.initials: CC
authors.lastname: Vinluan
authors.forename: S S
authors.initials: SS
authors.lastname: Shetty
authors.forename: C
authors.initials: C
authors.lastname: Dragland
authors.forename: E L
authors.initials: EL
authors.lastname: Kaplan
authors.forename: D
authors.initials: D
authors.lastname: DelGrande
authors.forename: A
authors.initials: A
authors.lastname: Islam
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: R J
authors.initials: RJ
authors.lastname: Lozito
authors.forename: W M
authors.initials: WM
authors.lastname: Maniara
authors.forename: R E
authors.initials: RE
authors.lastname: Walter
authors.forename: W R
authors.initials: WR
authors.lastname: Mann
mesh_terms: D000284:Administration, Oral; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005347:Fibroblasts; D006801:Humans; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000378:metabolism; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D011422:Propionates; D047428:Protein Kinase Inhibitors; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D019344:Lactic Acid; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases