title: The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.
abstract: The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
authors.affiliation: Department of Molecular Carcinogenesis, Leiden University, The Netherlands.
authors.forename: C W
authors.initials: CW
authors.lastname: van der Houven van Oordt
authors.forename: R
authors.initials: R
authors.lastname: Smits
authors.forename: T G
authors.initials: TG
authors.lastname: Schouten
authors.forename: J J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
authors.forename: S L
authors.initials: SL
authors.lastname: Williamson
authors.forename: A
authors.initials: A
authors.lastname: Luz
authors.forename: P
authors.initials: P
authors.lastname: Meera Khan
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Eb
authors.forename: M L
authors.initials: ML
authors.lastname: Breuer
authors.forename: R
authors.initials: R
authors.lastname: Fodde
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000818:Animals; D004814:Epidermal Cyst / Q000235:genetics; D005260:Female; D018222:Desmoid Tumors / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D019656:Loss of Heterozygosity / Q000235:genetics; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000235:genetics; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics; D014965:X-Rays