title: Increased sensitivity to thyroid hormone replacement therapy followed by hyponatremia and eosinophilia in a patient with long-standing young-onset primary hypothyroidism.
abstract: We describe a 51-year-old woman with long-standing young-onset primary hypothyroidism. Serum cortisol, adrenocorticotropin, and arginine vasopressin levels were normal, but urinary excretion of 17-hydroxycorticosteroid was decreased. Administration of a very small initial dose of thyroid hormone induced severe acute complications including fever, palpitation, and sweating associated with a rapid decrease in serum thyrotropin level, a dramatic increase in serum alkaline-phosphatase level, and a decrease in serum total cholesterol level. A week later, the late complications of nausea, severe hyponatremia, and eosinophilia occurred. Serum cortisol level decreased slightly but remained within normal limits during this hyponatremic period. This rare case suggests that increased sensitivity to thyroid hormone can occur in long-standing primary hypothyroidism with biphasic clinical course of acute thyrotoxic complications followed by severe hyponatremia resembling hypoadrenocorticism.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Fukuoka City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujikawa
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Mizokami
authors.forename: M
authors.initials: M
authors.lastname: Shiratsuchi
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000652:urine; D000324:Adrenocorticotropic Hormone / Q000097:blood; D001127:Arginine Vasopressin / Q000097:blood; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007010:Hyponatremia / Q000097:blood / Q000139:chemically induced*; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D013963:Thyroid Hormones / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use*
chemical_list: D015065:17-Hydroxycorticosteroids; D013963:Thyroid Hormones; D001127:Arginine Vasopressin; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone