Hippocampal theta rhythm in anesthetized rats: role of AMPA glutamate receptors.
The present study describes the effects of intraseptal infusions of 1 nmol AMPA and 12 nmol NBQX on both frequency and amplitude of physostigmine-induced theta rhythm in urethane-anesthetized rats. Infusion of AMPA increased the theta frequency. This effect was blocked by a prior infusion of NBQX. Infusion of NBQX decreased the theta amplitude, and this effect was not altered by AMPA. These results suggest that the septal AMPA/glutamate receptors exert subtle modulatory influences on septohippocampal cells involved in theta rhythm generation.
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Laboratoire de Psychopharmacologie et Processus Cognitifs, Université Paris VII, France.
Bizot
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JC
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000502:physiology*; D012688:Septum Pellucidum / Q000502:physiology; D013826:Theta Rhythm / Q000187:drug effects; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D011810:Quinoxalines; D018091:Receptors, AMPA; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D010830:Physostigmine