title: Endometrial stromal sarcoma with clonal complex chromosome abnormalities. Report of a case and review of the literature.
abstract: Only eleven endometrial stromal sarcomas (ESS) with clonal chromosomal abnormalities have been reported in the literature. Of these, four have been reported to harbor the t(7;17) translocation. We report here an additional ESS that exhibited clonal complex chromosome abnormalities not described earlier: 38,XX,-1,del(1)(q11),-2,add(2)(p13),-3,der(4)add(4)(p12)psu dic(4;14)(q35;q11.2), add(6)(p21.3),add(7)(q22),del(7)(p11.2p13),-8,-9,add(9)(q34),- 10,add(10)(q24),-11,-11,ins(12;?) (q13;?),-14,-14,-15,ins(15;?)(q22;?),add(16)(q22),add(17)(q11.2),- 18,der(18)t(7;18)(q11.2;p11.2),-19, add(20)(p13),add(21)(p11.2),-22,add(22)(p11.2),+6mar in metaphase cells from primary short-term culture.
authors.affiliation: Department of Pathology, Kochi Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sonobe
authors.forename: J
authors.initials: J
authors.lastname: Iwata
authors.forename: M
authors.initials: M
authors.lastname: Furihata
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: T
authors.initials: T
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D018203:Sarcoma, Endometrial Stromal / Q000235:genetics* / Q000473:pathology