Effect of dietary supplementation of vitamin E in partial inhibition of Russell's viper venom phospholipase A2 induced hepatocellular and microsomal membrane damage in rats.
The current investigation furnishes a good correlation between the alpha-tocopherol content of the liver and microsomes and corresponding inhibition of Russell's viper venom phospholipase A2 inflicted damage to them. Dietary supplementation of d1-alpha-tocopherol at a concentration of 100 mg and 200 mg per kg of diet displayed less damage caused by venom phospholipase A2 in sharp contrast to the vitamin E deficient rats. alpha-tocopherol due presumably to the formation of complexes with the phospholipid hydrolysis products of the membranes, plays a significant role in membrane stabilization.
Mukherjee
A K
AK
Department of Biochemistry, Burdwan Medical College, India.
Maity
C R
CR
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D019587:Dietary Supplements; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010741:Phospholipases A / Q000633:toxicity*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014757:Viper Venoms / Q000633:toxicity*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D010743:Phospholipids; D014757:Viper Venoms; D014810:Vitamin E; D002784:Cholesterol; D010741:Phospholipases A; D054467:Phospholipases A2