Synthesis and receptor affinity of polysubstituted adenosines.
In a search for potent and selective adenosine agonists it has been found that 2-hexynyladenosine-5'-N-ethyluronamide (HENECA) displays high affinity at rat A2A receptor combined with a good A2A vs A1 selectivity. The finding that HENECA shows good affinity also for A3 receptors prompted us to investigate the effect of various substituents in different positions of this molecule.
Vittori
S
S
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
Camaioni
E
E
Costanzi
S
S
Volpini
R
R
Klotz
K N
KN
Cristalli
G
G
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D011485:Protein Binding; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism
D018047:Receptors, Purinergic P1; D011994:Recombinant Proteins; D000241:Adenosine