title: Synthesis and in vitro antiviral activity of some symmetrical phosphoramidate dimers of AZT.
abstract: The synthesis of some symmetrical phosphoramidate dimers of AZT is presented. The synthetic scheme includes the formation of the symmetrical H-phosphonate diester of AZT, followed by its conversion to several dinucleoside phosphoramidate analogues. The compounds were evaluated for their anti-retroviral activity.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Kers
authors.forename: J L
authors.initials: JL
authors.lastname: Girardet
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: C
authors.initials: C
authors.lastname: Perigaud
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: J
authors.initials: J
authors.lastname: Stawinski
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D019281:Dimerization; D006801:Humans; D009943:Organophosphorus Compounds / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D009943:Organophosphorus Compounds; D015215:Zidovudine