title: [Experimental study of prostacyclin on the survival of random skin flaps].
abstract: The purpose of this experiment was to observe the effect of PGI2 on the survival of the random skin flap. White rats used in the experiment were divided into preoperation (prevention) group, postoperation (treatment) group and the control group. A super-long random skin flap was created on the back of the animal. Postoperatively, the treatment group received intravenous injection of PGI2 while the control group received intravenous injection of normal saline. The blood supply, metabolism and hemorheology of the flap were analyzed. Results showed that the relative blood flow on the distal part of the flap was 41.3% in the treatment group and 22.4% in the control group. The survival rate of the flap of the treatment group was higher than that of the control. There were no differences between the prevention and the control groups. It is concluded that early postoperative injection of PGI2 could improve blood supply and rheology of the flap and increase its survival rate.
authors.affiliation: Department of Plastic Surgery, Nanfang Hospital, First Military Medical University, Guangzhouz.
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: J
authors.initials: J
authors.lastname: Luo
mesh_terms: D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps
chemical_list: D011464:Epoprostenol