title: Synthesis and antiviral activity of D- and L-isodideoxy nucleosides with exocyclic-methylene.
abstract: Novel D- and L-isodideoxynucleosides were synthesized starting from D- and L-xylose and evaluated for antiviral activities against HIV-1, HSV-1, HSV-2, HBV and HCMV, respectively.
authors.affiliation: Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: L S
authors.initials: LS
authors.lastname: Jeong
authors.forename: S J
authors.initials: SJ
authors.lastname: Yoo
authors.forename: H R
authors.initials: HR
authors.lastname: Moon
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008826:Microbial Sensitivity Tests
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; D006838:Hydrocarbons; C030011:carbene; D008697:Methane