title: PUVA treatment of vitiligo: a retrospective study of Turkish patients.
abstract: BACKGROUND
  Psoralen plus ultraviolet A (PUVA) is considered to be the treatment of choice for subtotal vitiligo; however, it is time consuming and carries certain health risks for both patients and physicians. This study attempts to evaluate the efficacy of the treatment in Turkish vitiligo patients.
  
  
  METHODS
  We have performed a retrospective study of 33 patients with vitiligo who received systemic PUVA therapy during the period 1985 to 1997, and have evaluated their response to treatment.
  
  
  RESULTS
  Overall, 28 patients (84%) showed some improvement; 12 patients experienced a repigmentation of 51-75% and six patients achieved greater than 75% repigmentation. Face and trunk lesions showed better repigmentation than other areas, whereas hands, feet, perioral, and periorbital areas were generally refractory to treatment. The age of the patient, age at onset of the disease, sex, disease duration, and degree of depigmentation prior to initiation of therapy had no influence on PUVA-induced repigmentation.
  
  
  CONCLUSIONS
  The distribution of vitiliginous skin must be taken into consideration before the initiation of PUVA therapy, as the response to treatment varies greatly with different body sites; hands, feet, perioral, and periorbital regions are particularly treatment resistant.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Sahin
authors.forename: U
authors.initials: U
authors.lastname: Hindioğlu
authors.forename: A
authors.initials: A
authors.lastname: Karaduman
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D012880:Skin Pigmentation / Q000187:drug effects; D016896:Treatment Outcome; D014421:Turkey; D014820:Vitiligo / Q000188:drug therapy*