[The relationship between apolipoprotein E gene polymorphism and coronary heart disease and arteriosclerotic cerebral infarction].
OBJECTIVE
To detect the relationship between ApoE gene polymorphism and coronary heart disease(CHD), arteriosclerotic cerebral infarction(ACI).


METHODS
Exon 4 of ApoE gene was analyzed in normal group(87 cases), CHD group(78 cases) and ACI group(55 cases) by a combination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct AgNO(3) staining technique.


RESULTS
Between the control group and CHD group, ACI group, chi(2) test showed no significant difference in genotype of E3/E3 (P>0.5, P>0.1, respectively); while mu test showed no significant difference in allele epsilon(2)(P>0.25, P>0.1, respectively), epsilon(4)(P>0.1, P>0.25, respectively) of ApoE.


CONCLUSIONS
No relationship between ApoE gene polymorphism and CHD and ACI was noted in this study.
Cao
W
W
Department of Medical Genetics, Harbin Medical University, Harbin, 150086 P.R.China. zhanggy@ems.hrbma.edu.cn
Chen
F
F
Teng
L
L
Wang
S
S
Fu
S
S
Zhang
G
G
D001057:Apolipoproteins E / Q000235:genetics*; D002544:Cerebral Infarction / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E