Mapping regulatory networks in microbial cells.
Genome sequences are the blueprints of diverse life forms but they reveal little information about how cells make coherent responses to environmental changes. The combined use of gene fusions, gene chips, 2-D polyacrylamide gel electrophoresis, mass spectrometry and 'old-fashioned' microbial physiology will provide the means to reveal a cell's regulatory networks and how those networks are integrated.
VanBogelen
R A
RA
Parke-Davis Pharmaceutical Research Division, Warner-Lambert, Ann Arbor, MI 48105, USA.
Greis
K D
KD
Blumenthal
R M
RM
Tani
T H
TH
Matthews
R G
RG
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D015180:Electrophoresis, Gel, Two-Dimensional; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D013058:Mass Spectrometry / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis; D014176:Protein Biosynthesis; D014158:Transcription, Genetic