title: C3-fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability.
abstract: Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.
authors.affiliation: Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Straface
authors.forename: B
authors.initials: B
authors.lastname: Natalini
authors.forename: D
authors.initials: D
authors.lastname: Monti
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: G
authors.initials: G
authors.lastname: Schettini
authors.forename: M
authors.initials: M
authors.lastname: Bisaglia
authors.forename: C
authors.initials: C
authors.lastname: Fumelli
authors.forename: C
authors.initials: C
authors.lastname: Pincelli
authors.forename: R
authors.initials: R
authors.lastname: Pellicciari
authors.forename: W
authors.initials: W
authors.lastname: Malorni
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002244:Carbon / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D037741:Fullerenes; D006801:Humans; D008855:Microscopy, Electron, Scanning
chemical_list: D000975:Antioxidants; C120713:C(3)-fullero-tris-methanodicarboxylic acid; D003998:Dicarboxylic Acids; D037741:Fullerenes; D002244:Carbon; C069837:fullerene C60