[Brachytherapy of the tumor bed after breast conserving surgery: new radiotherapeutic option in the management of early breast cancer].
OBJECTIVE
To initiate fractionated, interstitial high dose rate brachytherapy of the tumour bed as the sole radiation modality after breast conserving surgery.


METHODS
In 41 cases of selected stage I-II breast cancer the tumour bed was marked with titanium clips during breast conserving surgery. The tumour bed was implanted with flexible plastic catheters to deliver postoperative radiotherapy. In 8 cases 7 x 4.33 Gy (30.3 Gy), in 33 cases 7 x 5.2 Gy (36.4 Gy) interstitial 192Ir high dose rate brachytherapy was given to the clipped area. Irradiation of the whole conserved breast was omitted. The radiation side effects were assessed by mammograms and MRI-examinations.


RESULTS
At a median follow up of 17 (4-36) months neither distant nor regional failure was observed. Local recurrence was detected in 1/41 (2.4%) case. G2 radiation side effects were observed in 2/21 (9.5%).


CONCLUSIONS
Postoperative sole brachytherapy of the tumour bed with careful patient selection and adequate quality assurance seems to be a feasible alternative to whole breast teletherapy. Sole brachytherapy shortens the time of radiotherapy from 5-6 weeks to 5 days, and reduces the costs of treatment. The skin and volume sparing effect of interstitial irradiation may decrease the side effects of radiotherapy.
Polgár
C
C
Sugárterápiás Osztály, Országos Onkológiai Intézet, Budapest.
Major
T
T
Somogyi
A
A
Fodor
J
J
Sulyok
Z
Z
Tóth
J
J
Forrai
G
G
Németh
G
G
D000328:Adult; D000368:Aged; D001918:Brachytherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009367:Neoplasm Staging; D010347:Patient Care Planning; D011182:Postoperative Care; D011879:Radiotherapy Dosage
A tumorágy egyedüli brachyterápiája emlömegtartó mütét után: új sugárterápiás lehetöség a korai emlörák kezelésében.