Transient evoked otoacoustic emissions in laboratory animals.
Transient evoked otoacoustic emissions (TEOAEs) are much used clinically. However, it has been difficult to record them in small laboratory animals, and experimental manipulations designed to determine the generation mechanisms of this type of emission could not be performed. After refining the technique, based on the use of short clicks and a short amplifier gain suppression period, TEOAEs were recorded using the same instrumentation and techniques in rabbits, Psammomys obesus (fat sand rats), mice, rats and guinea pigs. Distortion product emissions were also recorded. The responses in each species differed with respect to threshold, magnitude, frequency spectrum and duration (endpoint). The ability to record TEOAEs routinely in laboratory animals should now allow for further experimentation on the mechanisms of their generation, on the cochlear amplifier in general and on the comparison of TEOAEs with distortion product emissions in individual species and animals.
Khvoles
R
R
Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Freeman
S
S
Sohmer
H
H
D000161:Acoustic Stimulation / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D000830:Animals, Laboratory; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000502:physiology*; D006168:Guinea Pigs; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors