[The duration of the action of a single dose of aspirin, kurantil and nicotinic acid during pregnancy complicated by EPH gestosis].
Disorders in the system of blood aggregation state control (BASC) reflects the severity of OPH-gestosis (edema, proteinuria, hypertension). The duration of the therapeutic effect of the applied antithrombotics has not been studied essentially. The parameters and duration of the effective responses in the BASC system after a single dose of aspirin, curantyl, and nicotinic acid were studied in 45 females with OPH-gestosis of moderate severity. The deaggregation effect of aspirin lasted 48 h, that of nicotinic acid persisted for 7 h., the effect of curantyl developed in 72 h. and lasted 24 h. The prescription of individually selected and controlled doses of activators of fibrinolysis and deaggregants makes it possible to abolish disorders of the BASC system in pregnant females with OPH-gestosis of moderate severity.
Udut
V V
VV
Institute of Pharmacology, Tomsk Research Center, Siberian Branch of Russian Academy of Medical Sciences, Russia.
Kairov
G T
GT
Borodulina
E V
EV
V'iugova
L M
LM
D000704:Analysis of Variance; D001241:Aspirin / Q000008:administration & dosage*; D004176:Dipyridamole / Q000008:administration & dosage*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D009525:Niacin / Q000008:administration & dosage*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D011225:Pre-Eclampsia / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D013997:Time Factors
D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D009525:Niacin; D004176:Dipyridamole; D001241:Aspirin
O dlitel'nosti deĭstviia odnokratnoĭ dozy aspirina, kurantila i nikotinovoĭ kisloty pri beremennosti, oslozhnennoĭ OPG-gestozom.