Cutaneous allergic reaction to intramuscular vitamin K1.
A 40-year-old woman with no pre-existing hepatic disease developed a cutaneous allergic reaction to intramuscular vitamin K1. She received this medication prophylactically prior to surgery, developed severe localized, and subsequently generalized, dermatitis, beginning 5 days after administration of the Konakion Cremophor-EL form of vitamin K1 by intramuscular injection at four sites on her thighs. Investigation by patch and intradermal testing revealed delayed-type hypersensitivity to Konakion Cremophor-EL, Konakion Mixed Micelles and pure vitamin K1, but not Cremophor-EL vehicle alone. This case is unusual because the patient was also shown to be patch test positive to vitamin K3 sodium bisulfite.
Wong
D A
DA
Skin and Cancer Foundation, Darlinghurst, New South Wales, Australia.
Freeman
S
S
D000328:Adult; D003875:Drug Eruptions / Q000150:complications / Q000209:etiology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D007273:Injections, Intramuscular; D007428:Intradermal Tests; D010328:Patch Tests; D011537:Pruritus / Q000209:etiology; D014812:Vitamin K / Q000009:adverse effects; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000009:adverse effects*
D014812:Vitamin K; D010837:Vitamin K 1