[Polymorphism of the IL1RN gene in Spanish patients with ulcerative colitis].
BACKGROUND
The etiology of the inflammatory bowel disease is unknown. Previous studies have shown an association between the allele 2 of IL1RN, the gene that encodes for the interleukin 1 receptor antagonist (IL-1ra), and the inflammatory bowel disease.


METHODS
We have analyzed the incidence of the IL1RN alleles in 41 patients with ulcerative colitis and in 40 healthy subjects.


RESULTS
Our results show the same allelic distribution between the subjects with ulcerative colitis and the healthy population.


CONCLUSIONS
These results suggest that the allelic variants of the VNTR of the IL-1ra gene are not associated to a higher susceptibility to ulcerative colitis in Spanish population.
González Sarmiento
R
R
Departamento de Medicina, Universidad de Salamanca. gonzalez@gugu.usal.es
Araoz
P
P
Rodríguez
R
R
Oliveira
A
A
Feranández Blanco
I
I
Sánchez Rodríguez
A
A
D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000235:genetics*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000235:genetics*; D013030:Spain
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins
Estudio de polimorfismos del gen IL1RN en pacientes españoles con colitis ulcerosa.