Paracetamol-induced fulminant hepatic failure in a child after 5 days of therapeutic doses.
We report the case of a two and a half year-old girl who developed fulminant hepatic failure following 5 days of regular oral ingestion of paracetamol, approximately 90 mg x kg-1 x day-1. She presented with the typical findings of hepatomegaly, encephalopathy, high ammonia levels, high transaminases, hypoglycaemia and lactic acidosis. After stabilization, she was transferred to a specialist paediatric liver failure unit and fortunately she made a full recovery with intensive medical management.
Morton
N S
NS
University of Glasgow, UK.
Arana
A
A
D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000201:enzymology / Q000628:therapy; D006801:Humans; D007223:Infant; D008111:Liver Function Tests
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen