title: Sensitivity in vitro of Plasmodium falciparum to three currently used antimalarial drugs on the western border of Thailand.
abstract: The sensitivity in vitro of Plasmodium falciparum to mefloquine, quinine and artemisinin was assessed in an area of multi-drug resistance on the Thai-Myanmar border, using the World Health Organization's microtest, based on schizont maturation inhibition. Participating individuals were exclusively those who had contracted their infections within Myanmar. A total of 34 successful tests were carried out for mefloquine and quinine, showing a marked decrease in sensitivity compared to previously published results. Ten artemisinin tests were successful, with many failures due to the poor storage stability of the test plates. The implications of the shelf-life of the artemisinin plates is discussed. These results contribute to setting a base line of sensitivity to artemisinin in vitro.
authors.affiliation: Liverpool School of Tropical Medicine, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Fèvre
authors.forename: G
authors.initials: G
authors.lastname: Barnish
authors.forename: P
authors.initials: P
authors.lastname: Yamokgul
authors.forename: W
authors.initials: W
authors.lastname: Rooney
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D002648:Child; D002675:Child, Preschool; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008297:Male; D015767:Mefloquine / Q000494:pharmacology*; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013785:Thailand
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin; D011803:Quinine; D015767:Mefloquine