title: Neurodegenerative diseases of Guam: analysis of TAU.
abstract: Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam.
authors.affiliation: Mayo Clinic Department of Pharmacology, Jacksonville, FL 32224, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Tur
authors.forename: L
authors.initials: L
authors.lastname: Buée
authors.forename: H R
authors.initials: HR
authors.lastname: Morris
authors.forename: S C
authors.initials: SC
authors.lastname: Waring
authors.forename: L
authors.initials: L
authors.lastname: Onstead
authors.forename: F
authors.initials: F
authors.lastname: Wavrant-De Vrièze
authors.forename: R
authors.initials: R
authors.lastname: Crook
authors.forename: V
authors.initials: V
authors.lastname: Buée-Scherrer
authors.forename: P R
authors.initials: PR
authors.lastname: Hof
authors.forename: R C
authors.initials: RC
authors.lastname: Petersen
authors.forename: P L
authors.initials: PL
authors.lastname: McGeer
authors.forename: A
authors.initials: A
authors.lastname: Delacourte
authors.forename: M
authors.initials: M
authors.lastname: Hutton
authors.forename: T
authors.initials: T
authors.lastname: Siddique
authors.forename: J E
authors.initials: JE
authors.lastname: Ahlskog
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: J C
authors.initials: JC
authors.lastname: Steele
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D003704:Dementia / Q000150:complications / Q000235:genetics*; D005260:Female; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins