title: Preparation and biopharmaceutical evaluation of nitrofurantoin loaded Eudragit RS100 and Eudragit RL 100 micropellets.
abstract: The objective of the present investigation was to prepare nitrofurantoin micropellets coated with a combination of Eudragit RS 100 and Eudragit RL100 taken in varying ratios to achieve a sustained nitrofurantoin serum and urinary level over a prolonged period of time without any side effect. The method adopted was phase separation coacervation induced by non-solvent addition. The physical nature of the coating film was improved by a protective colloid, polyisobutylene (0% to 3% w/w). The optimized formulations were extensively evaluated for particle size analysis, Scanning Electron Microscopy, stability studies and finally in vitro and in vivo release studies and their statistical evaluation and correlation.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Baidya
authors.forename: S
authors.initials: S
authors.lastname: Bedi
authors.forename: B K
authors.initials: BK
authors.lastname: Gupta
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000328:Adult; D001702:Biopharmaceutics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D006801:Humans; D008863:Microspheres; D009582:Nitrofurantoin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D010316:Particle Size
chemical_list: D000180:Acrylic Resins; C050528:Eudragit RS; D009582:Nitrofurantoin