Hepatoprotective activity of Ficus racemosa leaf extract on liver damage caused by carbon tetrachloride in rats.
An extract of the leaves of Ficus racemosa Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing chronic liver damage by subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks. The biochemical parameters SGOT, SGPT, serum bilirubin and alkaline phosphatase were estimated to assess the liver function. The activity of extract was also comparable to a standard liver tonic (Neutrosec).
Mandal
S C
SC
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700 032, India.
Maity
T K
TK
Das
J
J
Pal
M
M
Saha
B P
BP
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000473:pathology*; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin