title: Evaluation of the neurovirulence test for mumps vaccines.
abstract: Neurovirulence tests in Macaca fascicularis using commercial preparations of different vaccine bulks and a wild-type strain revealed that the test was unable to distinguish mixed from pure populations or a suitable vaccine from a related strain which has been shown to be associated with clinical meningitis. However, the test was able to distinguish a wild-type strain from the vaccine strains successfully. The ability of the test to discriminate between acceptable and unacceptable seeds requires further examination.
authors.affiliation: Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, U.K. mafzal@nibsc.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Afzal
authors.forename: S A
authors.initials: SA
authors.lastname: Marsden
authors.forename: R M
authors.initials: RM
authors.lastname: Hull
authors.forename: P A
authors.initials: PA
authors.lastname: Pipkin
authors.forename: M L
authors.initials: ML
authors.lastname: Bentley
authors.forename: P D
authors.initials: PD
authors.lastname: Minor
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000473:pathology / Q000821:virology; D002552:Cerebral Ventricles / Q000473:pathology / Q000821:virology; D002522:Chlorocebus aethiops; D006801:Humans; D008252:Macaca fascicularis; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000592:standards*; D009109:Mumps virus / Q000472:pathogenicity; D012698:Serologic Tests; D012720:Severity of Illness Index; D014709:Vero Cells; D014774:Virulence
chemical_list: D009108:Mumps Vaccine