title: Total parenteral nutrition and tumor growth in malnourished patients with gastric cancer.
abstract: OBJECTIVE
  Evidence that total parenteral nutrition (TPN) can stimulate tumor growth in humans is scanty and contradictory. The purpose of this study was to evaluate the impact of TPN on tumor cell proliferation in malnourished patients receiving preoperative TPN.
  
  
  METHODS
  We evaluated variations in the S-phase cell fraction, defined as 3H-thymidine labeling index (TLI), before and after 10 days of TPN or non-administration of nutritional support in 19 malnourished patients (weight loss, > or = 10%) with gastric cancer. TLI was determined on endoscopic biopsies at the time of diagnosis, and subsequently on the operative specimen or through intraoperative sampling.
  
  
  RESULTS
  At diagnosis, a higher median TLI value was observed in the control than in the TPN group. Administration of TPN enhanced tumor cell proliferation in 50% of patients; however, at surgery there was no difference in the median TLI value of the two groups.
  
  
  CONCLUSIONS
  The TPN regimen seems to be associated with increased tumor cell proliferation, even though this stimulating effect was moderate and at surgery the TLIs of TPN patients and controls were not different. Although the potential stimulation probably has little consequence for patients receiving short-term preoperative nutrition, it may call for further investigation in cancer patients undergoing long-term home TPN.
authors.affiliation: Divisione di Chirurgia dell'Apparato Digerente A, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bozzetti
authors.forename: C
authors.initials: C
authors.lastname: Gavazzi
authors.forename: L
authors.initials: L
authors.lastname: Cozzaglio
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: P
authors.initials: P
authors.lastname: Spinelli
authors.forename: G
authors.initials: G
authors.lastname: Viola
mesh_terms: D000328:Adult; D000368:Aged; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009748:Nutrition Disorders / Q000209:etiology / Q000628:therapy*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications* / Q000209:etiology* / Q000473:pathology