title: Long-term stability of morphine and bupivacaine mixture for spinal use.
abstract: From clinical studies it has been proven that morphine in combination with bupivacaine is applicable in cancer pain. The availability of a ready to use parental dosage form of morphine and bupivacaine is comfortable for health care workers. Stability of a morphine or a bupivacaine preparation or a combination of both in a PVC cassette or polypropylene syringe for spinal use is examined in several studies. Apart from one study no data on long-term stability of morphine-bupivacaine mixture is available. A forced degradation study and a shelf-life study at room temperature (20-25 degrees C) were started on morphine hydrochloride 0.2 mg/ml and bupivacaine hydrochloride 7.5 mg/ml in 50 ml sterilized glass bottles type II. The results of the stability study showed that this mixture was stable up to 18 months at room temperature, whereafter morphine showed a slight degradation (5%) and bupivacaine remained stable.
authors.affiliation: Department of Clinical Pharmacy, University Hospital Nijmegen, The Netherlands.
authors.forename: C M
authors.initials: CM
authors.lastname: Essink-Tjebbes
authors.forename: D M
authors.initials: DM
authors.lastname: Burger
authors.forename: M
authors.initials: M
authors.lastname: Beelen
authors.forename: E W
authors.initials: EW
authors.lastname: Wuis
authors.forename: Y A
authors.initials: YA
authors.lastname: Hekster
mesh_terms: D000701:Analgesics, Opioid / Q000032:analysis*; D000779:Anesthetics, Local / Q000032:analysis*; D002045:Bupivacaine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007278:Injections, Spinal; D009020:Morphine / Q000032:analysis*; D019999:Pharmaceutical Solutions; D013696:Temperature
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D004338:Drug Combinations; D019999:Pharmaceutical Solutions; D009020:Morphine; D002045:Bupivacaine