Methylenecyclopropane analogues of nucleosides: synthesis, absolute configuration, and enantioselectivity of antiviral effect of (R)-(-)- and (S)-(+)-synadenol.
Synthesis, absolute configuration and antiviral activity of enantiomeric antiviral agents (R)-(-)- and (S)-(+)-synadenol (2 and 3a) are described.
Qiu
Y L
YL
Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.
Hempel
A
A
Camerman
N
N
Camerman
A
A
Geiser
F
F
Ptak
R G
RG
Breitenbach
J M
JM
Kira
T
T
Li
L
L
Gullen
E
E
Cheng
Y C
YC
Drach
J C
JC
Zemlicka
J
J
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006515:Hepatitis B virus / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism
D000998:Antiviral Agents; D003521:Cyclopropanes; C116544:synadenol; D000225:Adenine