title: 1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.
abstract: The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, UK.
authors.forename: T K
authors.initials: TK
authors.lastname: Vinh
authors.forename: M
authors.initials: M
authors.lastname: Ahmadi
authors.forename: P O
authors.initials: PO
authors.lastname: Delgado
authors.forename: S F
authors.initials: SF
authors.lastname: Perez
authors.forename: H M
authors.initials: HM
authors.lastname: Walters
authors.forename: H J
authors.initials: HJ
authors.lastname: Smith
authors.forename: P J
authors.initials: PJ
authors.lastname: Nicholls
authors.forename: C
authors.initials: C
authors.lastname: Simons
mesh_terms: D000616:Aminoglutethimide / Q000494:pharmacology; D000735:Androstenedione / Q000378:metabolism; D001141:Aromatase / Q000378:metabolism; D047072:Aromatase Inhibitors; D001572:Benzofurans / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D007659:Ketones / Q000138:chemical synthesis; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D047072:Aromatase Inhibitors; D001572:Benzofurans; D004791:Enzyme Inhibitors; D007659:Ketones; D013777:Tetrazoles; D014230:Triazoles; D000616:Aminoglutethimide; D000735:Androstenedione; D001141:Aromatase