title: [Second generation topical antihistaminics].
abstract: The article presents two topical antihistaminics: levocabastine and azelastine. Most attention is paid to discussing the pharmacokinetics and antihistamine, antiallergic and antiinflammatory activities of these drugs. Their clinical usefulness in allergic rhinitis and conjunctivitis is also presented. Finally the authors describe the adverse reaction observed after administrating of topical antihistaminics.
authors.affiliation: Kliniki Pneumonologii i Alergologii IMW AM w Lodzi, Oddział Ftizjopneumonologii.
authors.forename: M
authors.initials: M
authors.lastname: Pietrzkowicz
authors.forename: I
authors.initials: I
authors.lastname: Grzelewska-Rzymowska
mesh_terms: D000287:Administration, Topical; D018926:Anti-Allergic Agents / Q000493:pharmacokinetics*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics*; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism; D010793:Phthalazines / Q000493:pharmacokinetics*; D010880:Piperidines / Q000493:pharmacokinetics*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006634:Histamine H1 Antagonists; D010793:Phthalazines; D010880:Piperidines; D003577:Cytochrome P-450 Enzyme System; C047340:levocabastine; C020976:azelastine
vernacular_title: Leki przeciwhistaminowe drugiej generacji o działaniu miejscowym.