Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation.
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
Ohashi
H
H
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Takasaki, Gunma, Japan.
Ueno
A
A
Nakao
T
T
Ito
J
J
Kimura
K
K
Ishikawa
M
M
Kawai
H
H
Iijima
H
H
Osawa
T
T
D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry* / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
D018926:Anti-Allergic Agents; D001565:Benzoates; C111298:sulochrin