title: Rapid enlargement and recurrence of a preexisting intrasellar craniopharyngioma during the course of two pregnancies. Case report.
abstract: Enlargement of preexisting pituitary adenomas during pregnancy is well documented, but this phenomenon is unusual for nonendocrine pituitary tumors such as craniopharyngiomas. Only six cases of craniopharyngioma have been reported as presenting during pregnancy. The authors describe a 19-year-old woman who presented with amenorrhea and galactorrhea caused by an intrasellar mass. Seven months later, when she was 20 weeks pregnant, the patient developed sudden visual dysfunction. Emergency transsphenoidal surgery was performed to restore visual function, and the tumor was found to be a craniopharyngioma. The patient had spontaneous labor and delivered a healthy infant at term. The tumor recurred 4 years later, during her second pregnancy, and was again entirely removed via a second transsphenoidal approach. She again had a normal term delivery. During the 5-year follow-up period she has demonstrated no endocrinological or visual dysfunction. Control magnetic resonance images have revealed no recurrence of the tumor. The transsphenoidal approach seems to be the safest procedure to use during pregnancy to achieve an immediate optic nerve decompression and to preserve pituitary function.
authors.affiliation: Clinic of Neurosurgery, Sisli Etfal Hospital, Istanbul, Turkey. sezar@aidata.com.tr
authors.forename: Y
authors.initials: Y
authors.lastname: Aydin
authors.forename: S M
authors.initials: SM
authors.lastname: Can
authors.forename: A
authors.initials: A
authors.lastname: Gŭlkilik
authors.forename: O
authors.initials: O
authors.lastname: Tŭrkmenoglu
authors.forename: C
authors.initials: C
authors.lastname: Alatli
authors.forename: I
authors.initials: I
authors.lastname: Ziyal
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D003397:Craniopharyngioma / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000601:surgery; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy; D013100:Sphenoid Bone / Q000601:surgery
chemical_list: D006727:Hormone Antagonists; D001971:Bromocriptine