Positron emission tomography in juvenile Alexander disease.
A 13-year-old boy with cervical kyphosis was diagnosed as having juvenile Alexander disease because of the typical MRI findings, abnormally elevated alphaB-crystallin and heat shock protein 27 in the cerebrospinal fluid. Positron emission tomography with 18F-fluorodeoxyglucose demonstrated hypometabolism in the frontal white matter corresponding to the areas with leukodystrophy. However, the overlying gray matter preserved normal glucose metabolism.
Sawaishi
Y
Y
Department of Pediatrics, Akita University School of Medicine, Japan. sawaishi@med.akita-u.ac.jp
Hatazawa
J
J
Ochi
N
N
Hirono
H
H
Yano
T
T
Watanabe
Y
Y
Okudera
T
T
Takada
G
G
D000293:Adolescent; D000326:Adrenoleukodystrophy / Q000000981:diagnostic imaging* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008607:Intellectual Disability / Q000000981:diagnostic imaging* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000473:pathology; D009128:Muscle Spasticity / Q000000981:diagnostic imaging* / Q000473:pathology; D013131:Spine / Q000000981:diagnostic imaging; D013577:Syndrome; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed