title: Influence of chorioamnionitis on developmental outcome in very low birth weight infants.
abstract: OBJECTIVE
  To determine the effect of exposure to chorioamnionitis on developmental outcome in very low birth weight (VLBW) infants.
  
  
  METHODS
  Five hundred four maternal charts (97% of all VLBW infants delivered from 1990 to 1994) were reviewed. A historical cohort study of the 330 infants delivered secondary to preterm premature rupture of membranes or preterm labor was performed. Case subjects (71) were delivered of mothers with chorioamnionitis by clinical criteria; control subjects (259) were delivered of mothers without chorioamnionitis. Bayley index scores at 7 months' corrected age and special care nursery outcomes were compared. One hundred seventy-three subjects were necessary to reject the two-sided null hypothesis with 80% power with a difference in mean Bayley index scores of at least 8.
  
  
  RESULTS
  Neonatal sepsis (8.5% compared with 1.9%; odds ratio [OR] = 4.7, 95% confidence interval [CI] 1.4, 15.9, P = .015) and a low 5-minute Apgar (72% compared with 55%; OR = 2.1, CI 1.2, 3.8, P = .012) occurred more frequently in the chorioamnionitis group. One hundred eighty-seven (68%) of 273 surviving neonates had follow-up. Cases and controls were similar in mean Bayley mental developmental index (91.2 compared with 91.8, P = .84), Bayley psychomotor developmental index (89.8 compared with 89.1, P = .82), and number of infants developmentally delayed. Duration of exposure to chorioamnionitis did not affect neonatal outcome.
  
  
  CONCLUSIONS
  Despite higher rates of sepsis and low Apgar scores, no difference in outcome at 7 months of corrected age was detected in VLBW infants exposed to chorioamnionitis. Contemporary neonatal management may reduce the adverse effects of this exposure.
authors.affiliation: Department of Obstetrics and Gynecology, Center for Statistical Sciences, Brown University, Women and Infants' Hospital, Providence, Rhode Island, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Dexter
authors.forename: M P
authors.initials: MP
authors.lastname: Malee
authors.forename: H
authors.initials: H
authors.lastname: Pinar
authors.forename: J W
authors.initials: JW
authors.lastname: Hogan
authors.forename: M W
authors.initials: MW
authors.lastname: Carpenter
authors.forename: B R
authors.initials: BR
authors.lastname: Vohr
mesh_terms: D000328:Adult; D002821:Chorioamnionitis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D019102:Infant, Very Low Birth Weight; D008297:Male; D011247:Pregnancy