Kanglemycin C vs ciclosporin on immunosuppression in mice.
OBJECTIVE
To study inhibitory effects of kanglemycin C (Kan) on the mouse immune system, and compare with the effects of ciclosporin (Cic).


METHODS
Delayed hypersensitivity (DH) and cyclophosphamide-potentiated DH induced by dinitrofluorobenzene (DNFB); heart allograft and skin allograft; hemolysin; the phagocytosis of the peritoneal macrophage.


RESULTS
Kan (12.5, 25, 50 mg.kg-1.d-1, ig, 8 d) markedly inhibited DH and cyclophosphamide-potentiated DH induced by DNFB (P < 0.01), prolonged survival times of heart and skin allografts (P < 0.01), and decreased the content of hemolysin (P < 0.01), but had no significant effect on the neutral-red phagocytosis of the peritoneal macrophage (P > 0.05).


CONCLUSIONS
Kan had marked suppressive effects on cell-mediated and humoral-mediated immune responses, but no effect on phagocytosis of macrophage.
Li
J M
JM
Department of Pharmacology, Beijing Medical University, China.
Lin
Z B
ZB
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D005260:Female; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D006460:Hemolysin Proteins / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D012294:Rifamycins / Q000494:pharmacology*; D016038:Skin Transplantation; D016042:Transplantation, Heterotopic
D006460:Hemolysin Proteins; D007166:Immunosuppressive Agents; D012294:Rifamycins; C400787:kanglemycin C; D016572:Cyclosporine