title: Central nervous system depressant effect of Hoslundia opposita vahl.
abstract: The chloroform extract of the dried root of Hoslundia opposita has been evaluated for effects on the central nervous system (CNS). The extract significantly potentiated the phenobarbitone sleeping time in mice and produced a 60% protection against leptazol-induced convulsion. Neuropharmacological screening revealed CNS depression.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Olajide
authors.forename: S O
authors.initials: SO
authors.lastname: Awe
authors.forename: J M
authors.initials: JM
authors.lastname: Makinde
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000302:isolation & purification / Q000494:pharmacology*; D002725:Chloroform; D004357:Drug Synergism; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D009549:Nigeria; D010634:Phenobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012997:Solvents
chemical_list: D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D012997:Solvents; D002725:Chloroform; D010634:Phenobarbital