Energy-resolved mass spectrometry: a comparison of quadrupole cell and cone-voltage collision-induced dissociation.
Collision-induced dissociation (CID) can be effected in the interface region between atmospheric pressure ionization sources and single quadrupole mass analyzers. By varying the electric field in these cone-voltage CID experiments energy-resolved mass spectra can be obtained leading to breakdown graphs exploring the energy evolution of the fragmentation pathways. The breakdown graphs obtained from these cone-voltage CID studies are very comparable to those obtained by varying the collision energy in the quadrupole collision cell of a BEqQ mass spectrometer. The comparison has been made for the protonated peptides H-Leu-Gly-Gly-OH, H-Gly-Leu-Gly-OH, H-Gly-Gly-Leu-OH and Leu-enkephalin
Harrison
A G
AG
Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada. aharriso@alchemy.chem.utoronto.ca
D000818:Animals; D004743:Enkephalin, Leucine / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D010455:Peptides / Q000737:chemistry*
D010455:Peptides; D004743:Enkephalin, Leucine