Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety.
A series of d4T analogues have been synthesised in which the 2',3'-didehydro-2',3'-dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a stereoselective approach has been achieved with view to permit more detailed studies.
Ewing
D F
DF
Department of Chemistry, University of Hull, UK.
Fahmi
N
N
Mackenzie
G
G
Pranzo
A
A
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D018119:Stavudine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D001572:Benzofurans; D018894:Reverse Transcriptase Inhibitors; D018119:Stavudine; C105430:benzofuran