A patient with pseudohypoaldosteronism type 1 and respiratory distress syndrome.
We present a patient born at 36 weeks' gestation with respiratory distress, who required 6 days of mechanical ventilation, without a demonstrable infectious cause. He also developed hyponatremia, hypernatriuria, elevated serum aldosterone levels, and probable pseudohypoaldosteronism type 1 (PHA-1). This appears to be the first reported human case of both respiratory distress and a renal salt wasting process with elevated serum aldosterone. In animal models, abnormalities of subunits of the epithelial sodium channel produce respiratory distress and PHA-1. This patient's clinical presentation could be due to the same processes.
Malagon-Rogers
M
M
Department of Pediatrics, University of Tennessee Medical Center at Knoxville, 37919, USA. mmalagon@mc.utmck.edu
D000450:Aldosterone / Q000097:blood; D006801:Humans; D007010:Hyponatremia / Q000150:complications; D007231:Infant, Newborn; D008297:Male; D011546:Pseudohypoaldosteronism / Q000097:blood / Q000145:classification / Q000150:complications* / Q000652:urine; D013902:Radiography, Thoracic; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D012964:Sodium / Q000652:urine
D000450:Aldosterone; D012964:Sodium