title: Structure and function of facilitative sugar transporters.
abstract: Sugar transporters from one group of the major facilitator superfamily of membrane transporters. A conserved common central pore structure lies at the heart of these transporters and diverse functionality is brought about by alterations to this pore or regions associated with it. Recent mutagenesis studies of sugar transporters within the framework of tenable models for the distantly related lactose permease argue that this model is a good paradigm for other members of the major facilitator superfamily.
authors.affiliation: Divisions of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. M.Barrett@bio.gla.ac.uk
authors.forename: M P
authors.initials: MP
authors.lastname: Barrett
authors.forename: A R
authors.initials: AR
authors.lastname: Walmsley
authors.forename: G W
authors.initials: GW
authors.lastname: Gould
mesh_terms: D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000201:enzymology; D051272:Glucose Transporter Type 1; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D009004:Monosaccharide Transport Proteins / Q000737:chemistry / Q000502:physiology*; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D051272:Glucose Transporter Type 1; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins