T-cell activation and the dynamic world of rafts.
Recent evidence, indicates that T-cell receptor (TCR) triggering and T-cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.
Viola
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Basel Institute for Immunology, Switzerland.
Lanzavecchia
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D000818:Animals; D003599:Cytoskeleton / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell