The role of oxidative stress in diseases caused by mineral dusts and fibres: current status and future of prophylaxis and treatment.
Inhalation of silica and asbestos fibres by humans can lead to fibrosis of the lung and cancer. Different mechanistic approaches, including oxidative stress, are used for prophylactic and therapeutic interventions to attenuate the fibrogenic and carcinogenic effects of these particles. Thus far, most of these therapeutic interventions have been only partly successful. A review of the mechanisms which are thought to be involved in mineral particle-induced toxicity and the relevant therapeutic interventions used to date to counteract these mechanisms, will help formulate better prophylactic and treatment intervention strategies in the future.
Gulumian
M
M
National Centre for Occupational Health and Department of Medical Biochemistry, Johannesburg, South Africa.
D000818:Animals; D001195:Asbestosis / Q000517:prevention & control; D001665:Binding Sites; D004391:Dust / Q000009:adverse effects*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D019016:Mineral Fibers / Q000009:adverse effects*; D009784:Occupational Diseases / Q000517:prevention & control*; D018384:Oxidative Stress; D012822:Silicon Dioxide; D013499:Surface Properties
D004391:Dust; D019016:Mineral Fibers; D012822:Silicon Dioxide