title: Increased levels of nitric oxide metabolites in urine from leprosy patients in reversal reaction.
abstract: We measured the metabolites of NO [nitrite (NO2-) and nitrate (NO3-)] in urine from Ethiopian patients suffering from leprosy. The urinary level of NO2-/NO3- in a group of healthy Ethiopians was 1020 +/- 471 microM (n = 22). Leprosy patients in reversal reaction had significantly higher levels of NO2-/NO3- (1817 +/- 492 microM, p < 0.001, n = 12) than both the control group and leprosy patients who were not in reversal reaction (1079 +/- 446 microM, n = 12). We conclude that the reversal reaction in leprosy in associated with increased urinary levels of nitric oxide metabolites.
authors.affiliation: Department of Medical Microbiology, Faculty of Health Sciences, Linköping University, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Schön
authors.forename: N
authors.initials: N
authors.lastname: Gebre
authors.forename: T
authors.initials: T
authors.lastname: Sundqvist
authors.forename: H S
authors.initials: HS
authors.lastname: Habetmariam
authors.forename: T
authors.initials: T
authors.lastname: Engeda
authors.forename: S
authors.initials: S
authors.lastname: Britton
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D007918:Leprosy / Q000175:diagnosis / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism / Q000652:urine*; D011379:Prognosis; D012008:Recurrence; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide