[Intra-arterial chemotherapy in the treatment of liver metastases of colorectal cancer].
OBJECTIVE
The authors evaluate the value of hepatic intrarterial chemotherapy (HAC) as an alternative treatment for hepatic metastases from colo-rectum cancer unsuited to radical surgery.


METHODS
This study evaluates the physiopathological and pharmacodynamic bases for this type of treatment, the correct procedure for patient staging and selection, the surgical technique used to insert the infusional system, surgical complications and those linked to endoarterial treatment, the evaluation of response and the results. Complications correlated to the infusional system were evaluated in a total of 1223 patients in 10 non-randomised studies and 7 randomised studies taken from the literature. Complications correlated to chemotherapy were analysed in a total of 777 patients from 8 randomised studies and 7 randomised using FUDR. Special emphasis was placed on the possible association of locoregional and systemic treatment in order to prevent extrahepatic progression, the main cause of death in patients undergoing a single cycle of HAC.


RESULTS
By comparing locoregional and systemic treatment taken from a number of randomised and non-randomised studies, the results were evaluated in terms of objective response and survival.


CONCLUSIONS
There was no proportional increase in survival rates compared to systemic treatment only, in spite of the large proportion of objective responses achieved using locoregional treatment alone.
Lupo
F
F
Dipartimento di Discipline Chirurgiche e Anatomiche, Università degli Studi, Palermo.
Lisuzzo
A
A
Cajozzo
M
M
Vitale
D
D
La Mendola
G
G
Di Tora
P
P
Bazan
P
P
D000230:Adenocarcinoma / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary*; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000473:pathology*; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000556:secondary*; D009367:Neoplasm Staging; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D016896:Treatment Outcome
D000970:Antineoplastic Agents
La chemioterapia intrarteriosa nel trattamento delle metastasi epatiche da cancro del colon-retto.