The effect of folic acid on the drug metabolizing liver function in man with viral hepatitis.
The investigations were carried out on 31 patients (16 men and 15 women, at the age of 20-50) with viral hepatitis. The all patients were divided at two groups. The first group (12 man) received usual treatment (diet, corsil), the second group (19 man) received in addition to the base treatment folic acid (5 mg per day, 10 days). It was found, that at patients with viral hepatitis was decreased the activity of monooxygenase system of liver. So, period of semielimination (T1/2) of antipyrine (AP) was greater in 1,4 time, area under the pharmacokinetic curve - 1,5 time and clearance was below by 39% than in volunteers (29 man). On day of treatment only by corsil, the rate of elimination of AP and clearance were increased by 34 and 31% (p < 0.05) respectively, T1/2 was decreased by 23% (p < 0.05) and area under the pharmacokinetic curve - 17 %. On 10 day of treatment by corsil with folic acid (5 mg per day), the rate of elimination of AP and clearance was increased by 43% (p < 0.05), area under the pharmacokinetic curve and T 1/2 were decreased by 30 and 33% (p < 0.05) respectively. The positive effect of folic acid in treatment of hepatitis at restoration period may be cause participating its derivatives in de novo nucleotide synthesis.
Zviarynski
I U
IU
Laboratory of Biochemical Pharmacology, Institute of Biochemistry, Grodno, Belarus. zverin@biochem.belpak.grodno.by
Zavodnik
L B
LB
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000983:Antipyrine / Q000493:pharmacokinetics; D001663:Bilirubin / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D006506:Hepatitis A / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D005492:Folic Acid; D000410:Alanine Transaminase; D001663:Bilirubin; D000983:Antipyrine