Miniaturized FRET assays and microfluidics: key components for ultra-high-throughput screening.
Assay miniaturization applicable across a wide range of target classes, along with automation and process integration, are well-recognized goals for ultra-high-throughput screening on an industrial scale. This report summarizes the implementation of fluorescence resonance energy transfer (FRET)-based biochemical and cell-based assays in 3456-well NanoWelltrade mark assay plates using key components of Aurora's ultra-high-throughput screening system.
Mere
L
Aurora Biosciences Corporation, 11010 Torreyana Road, San Diego, CA 92121, USA.
Bennett
T
Coassin
P
England
P
Hamman
B
Rink
T
Zimmerman
S
Negulescu
P