Lactic dehydrogenase virus inhibits allergic immunoglobulin E production: in vivo molecular analysis of cytokines.
The effects of lactic dehydrogenase virus (LDV) infection on allergic immunoglobulin (Ig)E production and interleukin (IL)-4 gene expression were studied. LDV infection suppressed antigen-induced IgE production in sensitized mice. The elevations of IL-4 gene expression in spleen and mesenteric lymph nodes 3 and 7 days after ovalbumin challenge were suppressed significantly in LDV-infected mice compared with control mice. The expression of the interferon (IFN)-gamma gene of mesenteric lymph nodes was significantly increased in LDV-infected mice. These results suggest that LDV infection suppressed antigen-induced IgE production by decreasing IL-4 production, and that suppression of IL-4 gene expression may be mediated by a mutual inhibition mechanism between T helper (Th)1 and Th2 cells.
Morimoto
M
M
Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan.
Iwata
H
H
Hayashi
T
T
D000485:Allergens / Q000276:immunology; D000818:Animals; D018174:Arterivirus Infections / Q000276:immunology*; D015870:Gene Expression; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D007772:Lactate dehydrogenase-elevating virus / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology
D000485:Allergens; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma; D010047:Ovalbumin