title: Transition metal complexes of 2-acetylpyridine o-hydroxybenzoylhydrazone (APo-OHBH): their preparation, characterisation and antimicrobial activity.
abstract: Coordination compounds of some transition metal ions with 2-acetylpyridene-o-hydroxybenzoylhydrazone (APo-OHBH) were synthesized. Their structures have been characterised by elemental analyses, electrical conductance, magnetic moments (at 25 degrees C) and spectral (IR, UV, NMR) studies. The fast atom bombardment (FAB) method was used for obtaining mass spectra of the positive ion FAB studies of the ligand and some metal complexes. The thermal behaviour of selected complexes was investigated by thermal gravimetrical analysis (TGA) and differential thermal analysis (DTA) techniques. The IR spectra show that the ligand acts in a neutral bidentate, neutral tridentate and/or mononegative tridentate fashion depending on the metal salt used and the medium of the reaction. Preliminary pharmacological tests on the ligand and its complexes showed some antimicrobial activity.
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Egypt.
authors.forename: N
authors.initials: N
authors.lastname: Nawar
authors.forename: N M
authors.initials: NM
authors.lastname: Hosny
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004055:Differential Thermal Analysis; D004926:Escherichia coli / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: C122039:2-acetylpyridine o-hydroxybenzoylhydrazone; D000900:Anti-Bacterial Agents; D006835:Hydrazones; D008024:Ligands; D008670:Metals; D011725:Pyridines