C3-fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability.
Anoikia is a type of apoptotic cell death that occurs in cells that are substrate-restricted in their growth. Buckminsterfullerenes represent a new class of chemical compounds with wide potential pharmacological antioxidant activity. In this report we provide the first demonstration that a water-soluble fullerene derivative, C3-fullero-tris-methanodicarboxylic acid, synthesized in our laboratories, is capable of inducing anoikia resistance in epithelial cells by a mechanism involving a 'trophic' effect on cell spreading-associated cytoskeletal components, i.e. on actin microfilaments.
Straface
E
E
Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
Natalini
B
B
Monti
D
D
Franceschi
C
C
Schettini
G
G
Bisaglia
M
M
Fumelli
C
C
Pincelli
C
C
Pellicciari
R
R
Malorni
W
W
D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002244:Carbon / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D037741:Fullerenes; D006801:Humans; D008855:Microscopy, Electron, Scanning
D000975:Antioxidants; C120713:C(3)-fullero-tris-methanodicarboxylic acid; D003998:Dicarboxylic Acids; D037741:Fullerenes; D002244:Carbon; C069837:fullerene C60