Immunization of laboratory animals with ultraviolet-attenuated larvae against homologous challenge infection with Trichinella britovi.
Immunogenicity of Trichinella britovi (Japanese isolate, cord ISS 408) muscle larvae irradiated with 5 mJ/cm2 of short wavelength ultraviolet (UV) was studied using homologous challenge infections. SCID mice vaccinated with UV-attenuated larvae showed no resistance, although its congenic CB-17 mice exhibited remarkable immunity. Following challenge vaccinated Mongolian gerbils, Meriones unguiculatus, did not show significant immunity. Use of these animal models vaccinated with UV-attenuated larvae will contribute to the investigation of immune mechanisms against Trichinella infection and also to the development of a vaccine of trichinellosis.
Nakayama
H
H
Department of Parasitology, Hirosaki University School of Medicine, Aomori, Japan.
Inaba
T
T
Nargis
M
M
Chisty
M
M
Ito
M
M
Kamiya
H
H
D000818:Animals; D005849:Gerbillinae; D007814:Larva / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D016513:Mice, SCID; D013045:Species Specificity; D014234:Trichinella / Q000276:immunology* / Q000302:isolation & purification / Q000528:radiation effects; D014235:Trichinellosis / Q000276:immunology*; D014611:Vaccination