Novel A,B,E-ring-modified camptothecins displaying high lipophilicity and markedly improved human blood stabilities.
Bom
D
D
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Curran
D P
DP
Chavan
A J
AJ
Kruszewski
S
S
Zimmer
S G
SG
Fraley
K A
KA
Burke
T G
TG
D002166:Camptothecin / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005454:Fluorescence Polarization; D006801:Humans; D006868:Hydrolysis; D010715:Phosphatidylglycerols / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship; D059004:Topoisomerase I Inhibitors
D004791:Enzyme Inhibitors; D010715:Phosphatidylglycerols; D059004:Topoisomerase I Inhibitors; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine; D002166:Camptothecin