title: [Severe interstitial lung disease from pathologic gastroesophageal reflux in children].
abstract: Interstitial lung diseases comprise a heterogeneous group of pulmonary conditions that cause restrictive lung disease of poor prognosis, especially if growth failure, pulmonary hypertension and fibrosis appears. We report on the case of a girl of 11 years of age who suffered from severe nonallergic asthma in early childhood and who developed severe interstitial pulmonary disease caused by gastro-oesophageal reflux at the age of 8 years. This diagnosis was established by lung biopsy, bronchoalveolar lavage and a high amount of lipid-laden alveolar macrophages, 2-level pH measurement and oesophageal biopsy. Because therapy with oral and inhaled steroids failed and Omeprazol showed benificial effects, hemifundoplication according to THAL was performed. At present the lung function is clearly normal and there is no need of any medicaments. Following the history, we can assume the pathological gastro-oesophageal reflux to be the cause of the disease. It is important to state that there were no typical symptoms at any time pointing to gastro-oesophageal reflux disease. The development of pulmonary disease by pathological reflux is very often caused by "silent aspiration". Very typically there are no symptoms such as vomiting, heartburn and pain but only signs of chronic lung disease.
authors.affiliation: Abt. allg. Pädiatrie II, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
authors.forename: P
authors.initials: P
authors.lastname: Ahrens
authors.forename: B
authors.initials: B
authors.lastname: Weimer
authors.forename: D
authors.initials: D
authors.lastname: Hofmann
mesh_terms: D001249:Asthma / Q000150:complications*; D002648:Child; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
vernacular_title: Schwere interstitielle Lungenerkrankung durch pathologische gastroösophageale Refluxaktivität im Kindesalter.