title: Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection.
abstract: Normal mice inoculated intravenously with 50 microg trehalose-6,6'-dimycolate, a glycolipid component of the cell wall of Mycobacterium, in an oil-in-water emulsion (TDM emulsion) acquired a high resistance to intranasal lethal infection of an influenza virus. In contrast, TDM emulsion-treated T-cell receptor delta gene mutant (TCR delta-/-) mice acquired insufficient resistance against the lethal influenza virus infection. The patterns of insufficient resistance were identical to the results obtained previously with mice which were depleted of T-lymphocytes bearing gammadelta T-cell receptors (gammadelta T-cells) by in vivo administration of anti-gammadelta T-cell receptor monoclonal antibody (Hoq et al, J. Gen. Virol. 78: 1597-1603, 1997). These results strongly suggest that the gammadelta T-cells play an important non-specific role in resistance against influenza virus infection.
authors.affiliation: Department of Microbiology, Asahikawa Medical College, Japan.
authors.forename: M M
authors.initials: MM
authors.lastname: Hoq
authors.forename: T
authors.initials: T
authors.lastname: Suzutani
authors.forename: K
authors.initials: K
authors.lastname: Nakaya
authors.forename: I
authors.initials: I
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Shibaki
authors.forename: S
authors.initials: S
authors.lastname: Itohara
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Azuma
mesh_terms: D000818:Animals; D003311:Cord Factors / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D019676:Genes, T-Cell Receptor delta; D007113:Immunity, Innate; D009980:Influenza A virus; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009154:Mutation; D009169:Mycobacterium tuberculosis; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000401:mortality; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
chemical_list: D003311:Cord Factors; D004655:Emulsions