The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction.
The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.
Lupher
M L
ML
ICOS Corporation, Bothell, WA 98021, USA.
Rao
N
N
Eck
M J
MJ
Band
H
H
D000818:Animals; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D050721:Proto-Oncogene Proteins c-cbl; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D044767:Ubiquitin-Protein Ligases
D011518:Proto-Oncogene Proteins; D011971:Receptors, Immunologic; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D011505:Protein-Tyrosine Kinases; C067419:CBL protein, human