Polymorphism of the 5'-flanking region of the tumor necrosis factor (TNF)-alpha gene and susceptibility to human T-cell lymphotropic virus type I (HTLV-I) uveitis.
The genetic background of human T-cell lymphotropic virus type I (HTLV-I) uveitis (HU) was investigated by studying the distribution of 5 polymorphisms of the 5'-flanking promoter/enhancer region of the tumor necrosis factor (TNF)-alpha gene in patients with HU, together with patients with adult T-cell leukemia (ATL), asymptomatic HTLV-I carriers, and healthy controls. The frequencies of the -1,031C allele (T-->C transition at position -1,031) and -863A allele (C-->A transition at position -863) in the HU patients, but neither in the ATL patients nor in the carriers, were significantly higher than those in the controls. The -1,031C and -863A alleles, in the absence of the HLA B61 or the DRB1*0901 allele which is in linkage disequilibrium with these alleles, were associated with increased susceptibility to HU. These results suggest that the -1,031C and -863A alleles might be genetic risk factors for HU.
Seki
N
N
Department of Immunology, Kurume University School of Medicine, Kurume, Japan.
Yamaguchi
K
K
Yamada
A
A
Kamizono
S
S
Sugita
S
S
Taguchi
C
C
Matsuoka
M
M
Matsumoto
H
H
Nishizaka
S
S
Itoh
K
K
Mochizuki
M
M
D000328:Adult; D002353:Carrier State / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000276:immunology; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D015490:HTLV-I Infections / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007564:Japan; D011110:Polymorphism, Genetic; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014605:Uveitis / Q000235:genetics / Q000276:immunology / Q000821:virology*
D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D014409:Tumor Necrosis Factor-alpha