title: Clomipramine treatment of delusional disorder, somatic type.
abstract: Four patients of delusional disorder, somatic type, were treated with clomipramine 60-120 mg/day. All patients showed marked clinical improvement after 27-57 days of clomipramine treatment. In one case, previous treatments by various antipsychotic drugs including pimozide had been unsuccessful. This report suggests that clomipramine is effective at least for some patients with delusional disorder, somatic type, including pimozide-resistant cases. It is also suggested that there is some association between delusional disorder, somatic type, and serotonergic dysfunction.
authors.affiliation: Department of Neuropsychiatry, Yamagata University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Kawakatsu
authors.forename: T
authors.initials: T
authors.lastname: Nadaoka
authors.forename: N
authors.initials: N
authors.lastname: Okuyama
authors.forename: K
authors.initials: K
authors.lastname: Otani
mesh_terms: D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002997:Clomipramine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006998:Hypochondriasis / Q000188:drug therapy / Q000523:psychology; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000627:therapeutic use; D011602:Psychophysiologic Disorders / Q000188:drug therapy* / Q000523:psychology; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000523:psychology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D010868:Pimozide; D002997:Clomipramine