title: Protection of fattening pigs against challenge with Aujeszky's disease virus after a successive intranasal/intramuscular vaccination.
abstract: In this study, the efficacy of successive intranasal (i.n.)/intramuscular (i.m.) vaccination against Aujeszky's disease virus (ADV) was assessed in experimental pigs. The double deletion-mutant Kaplan gE-gl- was used for i.n. vaccination at 4 weeks of age and the commercially available Bartha strain, suspended in an oil-in-water emulsion, was used for the i.m. booster vaccination at 10 weeks of age. Efficacy was compared with that of the traditional double i.m. vaccination with the commercially available Bartha strain at 10 and 14 weeks of age by challenging the pigs at the end of the fattening period. There were significant differences in clinical signs, mean daily weight gain, and virus excretion between the vaccinated groups and the unvaccinated controls; however, the differences between the vaccinated groups were not statistically significant.
authors.affiliation: Laboratory of Virology, Faculty of Veterinary Medicine, University of Gent, Merelbeke, Belgium.
authors.forename: G G
authors.initials: GG
authors.lastname: Labarque
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauwynck
authors.forename: D G
authors.initials: DG
authors.lastname: Maes
authors.forename: M B
authors.initials: MB
authors.lastname: Pensaert
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D011558:Herpesvirus 1, Suid / Q000502:physiology*; D018928:Immunity, Mucosal; D007273:Injections, Intramuscular / Q000662:veterinary; D009500:Neutralization Tests / Q000662:veterinary; D011557:Pseudorabies / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D022421:Pseudorabies Vaccines; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*; D014779:Virus Replication; D017201:Virus Shedding
chemical_list: D022421:Pseudorabies Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines