Design and application of multimodular peptide synthetases.
Nonribosomal peptide synthetases produce bioactive peptides of great structural diversity. Their modular organization makes them amenable to the construction of hybrid enzymes that synthesize novel products. New strategies for combinatorial approaches are being developed from the recent advances in nonribosomal peptide synthesis on the genetic, biochemical and structural level.
Mootz
H D
HD
Fachbereich Chemie/Biochemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35032, Marburg, Germany. Mootz@ps1515.chemie.uni-marburg.de
Marahiel
M A
MA
D001709:Biotechnology; D015195:Drug Design; D004792:Enzyme Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D066298:In Vitro Techniques; D010453:Peptide Synthases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015202:Protein Engineering; D011499:Protein Processing, Post-Translational
D004792:Enzyme Precursors; D010453:Peptide Synthases