title: Surgery or radiotherapy for early stages carcinomas of the glottic larynx.
abstract: OBJECTIVE
  The choice of treatment in limited squamous cell carcinoma of the glottic larynx often depends on individual and tumor factors. Data of the literature clearly show that surgery and radiotherapy tend to give identical results in terms of survival. We examined 196 cases of T1-T2/N0 cancers of the glottic larynx. We review the literature and discuss the indications and the efficacy of the various available treatments.
  
  
  METHODS
  196 consecutive cases of T1-T2/N0 cancers of the glottic larynx were examined. In 54.5% the tumor was confined to the vocal cord; in 38.2% it extended to the anterior commissure, in 4.6% to the arytenoid cartilage and in 2.5% to the floor of the ventricle. We performed partial laryngeal surgery in 41.3% (81 cases). Radiotherapy alone was employed in 58.6% (115 cases).
  
  
  RESULTS
  In T1a and T1b cases there was no statistically significant difference in 5-year disease-free survival. In T2 cases the NED survival of patients who underwent partial laryngectomies (90% of cases) was significantly better (P <0.05) than among patients given radiotherapy (73%). NED survival at 5 years in patients with the primary tumor on a vocal cord, ventricle or anterior commissure was 78%, 80% and 81%, respectively, with no statistically significant difference among the various sites. It is possible that involvement of the anterior commissure exposes patients to greater risk of recurrence when radiotherapy alone is used (5 out of 23 cases, 21.7%, compared to 3 out of 52 cases, 5.7%, among our surgically treated patients).
  
  
  CONCLUSIONS
  When the tumor is confined to the vocal cord and mobility is not impaired (T1a), surgery and radiotherapy give comparable results, and the latter yields a better functional outcome. When the anterior commissure is involved, recurrences appear to be less likely after surgery. In T2 glottic carcinoma, surgery gives better results than radiotherapy alone. In any event, the choice of treatment should be patient-specific and based on a careful analysis of the factors involved in each case.
authors.affiliation: Division of Otorhinolaryngology, Ospedale Mauriziano Umberto I, Turin, Italy. magnano@piw.it
authors.forename: M
authors.initials: M
authors.lastname: Magnano
authors.forename: A L
authors.initials: AL
authors.lastname: Cavalot
authors.forename: C F
authors.initials: CF
authors.lastname: Gervasio
authors.forename: W
authors.initials: W
authors.lastname: Lerda
authors.forename: P
authors.initials: P
authors.lastname: Gabriele
authors.forename: R
authors.initials: R
authors.lastname: Orecchia
authors.forename: M G
authors.initials: MG
authors.lastname: Ruo-Redda
authors.forename: G
authors.initials: G
authors.lastname: Beltramo
authors.forename: R
authors.initials: R
authors.lastname: Ragona
authors.forename: G
authors.initials: G
authors.lastname: Cortesina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018579:Patient Selection; D016896:Treatment Outcome