[A successful cadaveric renal-transplantation in a patient whose serum inorganic fluoride concentrations were extremely elevated during sevoflurane anesthesia].
We gave general anesthesia using sevoflurane to a patient undergoing cadaveric renal transplantation. Although the maximum inorganic fluoride concentration in the serum was unexpectedly high (74 uM) in the perioperative period, urine output from the transplanted kidney started simultaneously with reperfusion of the kidney and renal functions also recovered swiftly. Enzyme induction caused by anticonvulsants, which had been administered prior to operation, was assumed to be the cause of the elevation in serum inorganic fluoride concentrations in the patient. We recognized that inorganic fluoride ion is not a primary factor to aggravate functions of the transplanted kidney and concluded that sevoflurane could be selected as a volatile anesthetic used in renal transplant surgery.
Okutani
R
R
Department of Anesthesiology, Hyogo College of Medicine, Nishinomiya.
Uemura
Y
Y
Tanimoto
M
M
Kurehara
H
H
Fukushima
A
A
D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics; D000927:Anticonvulsants / Q000009:adverse effects; D002102:Cadaver; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation; D008738:Methyl Ethers / Q000493:pharmacokinetics; D008875:Middle Aged; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D000927:Anticonvulsants; D008738:Methyl Ethers; D000077149:Sevoflurane; D003577:Cytochrome P-450 Enzyme System; D005459:Fluorides