title: Responsiveness of clinical measures in children with oligoarticular juvenile chronic arthritis.
abstract: OBJECTIVE
  To compare the relative responsiveness of outcome measures in children with oligoarticular course juvenile chronic arthritis (JCA).
  
  
  METHODS
  Twenty-six consecutive children with JCA and < or =4 joints involved were assessed at admission and after 3 months of followup. Outcome measures included physician and parent global assessments, functional ability as measured by the Childhood Health Assessment Questionnaire (CHAQ), articular variables, and laboratory indicators of systemic inflammation. Responsiveness was calculated with the standardized response median, the effect size, and the Guyatt method.
  
  
  RESULTS
  The physician global assessment of disease activity, the active joint count, the global articular severity score, and the number and score of swollen joints proved consistently more responsive with either responsiveness measure used. The parent global assessment of the child's well being, the scores of joints with pain/tenderness and limited range of motion, and the number of joints with limited range of motion showed intermediate responsiveness. The CHAQ, morning stiffness, and laboratory indicators of systemic inflammation were the least responsive measures.
  
  
  CONCLUSIONS
  The subjective estimation of disease activity by the physician and the articular variables were the more responsive outcome measures in children with oligoarticular JCA. The assessment of functional ability as measured by the CHAQ showed a poor sensitivity to clinical change in this subset of patients with JCA.
authors.affiliation: Dipartimento di Scienze Pediatriche dell'Università, IRCCS Policlinico S. Matteo, Pavia, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Ruperto
authors.forename: A
authors.initials: A
authors.lastname: Ravelli
authors.forename: D
authors.initials: D
authors.lastname: Migliavacca
authors.forename: S
authors.initials: S
authors.lastname: Viola
authors.forename: A
authors.initials: A
authors.lastname: Pistorio
authors.forename: C
authors.initials: C
authors.lastname: Duarte
authors.forename: A
authors.initials: A
authors.lastname: Martini
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D005260:Female; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D007223:Infant; D008297:Male; D017063:Outcome Assessment, Health Care; D011795:Surveys and Questionnaires