Human papillomavirus as a risk factor for head and neck cancers--a case-control study.
A retrospective, case-control study was conducted to examine the relationship between the presence of human papillomavirus types 16 and 18 (HPV16/18) DNA and the risk of head and neck cancers. Twelve out of 74 (16.2%) head and neck cancers contained HPV16/18 DNA, while 3 out of 70 (4.2%) non-cancer controls showed HPV16/18 positivity by polymerase chain reaction. The presence of HPV16/18 DNA was associated with an increased risk of head and neck cancer formation, showing an odds ratio of 4.32, with a 95% confidence interval of 1.26-14.78. Although its epidemiological impact might be smaller than that of other factors like cigarette smoking, the presence of HPV16/18 DNA in the aerodigestive tract is suggested to be a risk factor for human head and neck cancers.
Nishioka
S
S
Department of Otolaryngology, Okayama University Medical School, Japan.
Fukushima
K
K
Nishizaki
K
K
Gunduz
M
M
Tominaga
S
S
Fukazawa
M
M
Monden
N
N
Watanabe
S
S
Masuda
Y
Y
Ogura
H
H
D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000821:virology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology*; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000453:epidemiology*
D004279:DNA, Viral