title: L-purine nucleosides as selective antimalarials.
abstract: L-nucleosides selectively enter malaria infected erythrocytes and have the unique ability to be metabolised by the malarial adenosine deaminase. This has allowed us to design novel L-nucleosides as potential anti-malarials.
authors.affiliation: School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, Australia.
authors.forename: A M
authors.initials: AM
authors.lastname: Gero
authors.forename: G
authors.initials: G
authors.lastname: Perrone
authors.forename: D M
authors.initials: DM
authors.lastname: Brown
authors.forename: S T
authors.initials: ST
authors.lastname: Hall
authors.forename: C K
authors.initials: CK
authors.lastname: Chu
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000469:parasitology; D010963:Plasmodium falciparum / Q000201:enzymology; D011684:Purine Nucleosides / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D011684:Purine Nucleosides; D000243:Adenosine Deaminase