title: Rare AIDS-defining diseases in the Swiss HIV Cohort Study.
abstract: The objective of this study was to investigate the spectrum and frequency of rare AIDS-defining diseases in the Swiss HIV Cohort Study. AIDS-defining diseases contributing less than 1% to the absolute number of all recorded AIDS-defining diseases in at least one of five periods (1988-1990, 1991-1992, 1993-1994, 1995-1996, 1997) were defined as being rare. A total of 9110 HIV-infected subjects were included in this study. Over the entire 9-year period, the following rare diseases were diagnosed: progressive multifocal leukoencephalopathy (n = 138), disseminated cryptococcosis (n = 67), visceral herpes simplex disease (n = 66), primary cerebral lymphoma (n = 65), indeterminate cerebral lesion (n = 50), cryptococcal meningitis (n = 34), Mycobacterium kansasii disease (n = 32), recurrent Salmonella septicemia (n = 22), intestinal isosporiasis (n = 21), candidiasis of the trachea, bronchi and lungs (n = 19), toxoplasma retinitis (n = 16), disseminated toxoplasmosis (n = 8), invasive cervical carcinoma (n = 8), extrapulmonary Pneumocystis disease (n = 5), disseminated histoplasmosis (n = 1) and disseminated coccidioidomycosis (n = 1). Rare diseases accounted for 7.3% of all AIDS-defining diseases over the entire 9-year period. Physicians should be aware of the likelihood of a broad spectrum of AIDS-defining diseases in HIV-infected patients.
authors.affiliation: Outpatient Department of Internal Medicine, University of Basel, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Burckhardt
authors.forename: P
authors.initials: P
authors.lastname: Sendi
authors.forename: D
authors.initials: D
authors.lastname: Pfluger
authors.forename: W
authors.initials: W
authors.lastname: Zimmerli
authors.forename: R
authors.initials: R
authors.lastname: Nüesch
authors.forename: H C
authors.initials: HC
authors.lastname: Bucher
authors.forename: J
authors.initials: J
authors.lastname: Drewe
authors.forename: N
authors.initials: N
authors.lastname: Gyr
authors.forename: M
authors.initials: M
authors.lastname: Battegay
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000453:epidemiology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D003453:Cryptococcosis / Q000150:complications / Q000453:epidemiology; D003710:Demography; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000453:epidemiology; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000453:epidemiology; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000453:epidemiology; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D013557:Switzerland / Q000453:epidemiology