Production of guanine from NH(4)CN polymerizations.
The synthesis of adenine from the polymerization of concentrated ammonium cyanide solutions is well known. We show here that guanine is also produced by this reaction but at yields ranging from 10 to 40 times less than that of adenine. This synthesis is effective at both +80 and -20 degrees C. Since high concentrations of NH(4)CN are obtainable only by freezing, this prebiotic synthesis would be applicable to frozen regions of the primitive Earth, the Jovian satellite Europa and other icy satellites, and the parent body of the Murchison meteorite.
Levy
M
M
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0506, USA.
Miller
S L
SL
Oró
J
J
D003486:Cyanides; D019418:Evolution, Chemical; D006147:Guanine / Q000138:chemical synthesis*; D008956:Models, Chemical; D000069497:Origin of Life; D013816:Thermodynamics
D003486:Cyanides; D006147:Guanine; C026524:ammonium cyanide