Association of lymphocytic colitis with linear IgA dermatosis.
The case of a 66-year-old female patient is presented, who suffered from chronic watery diarrhea. In addition, she developed linear IgA dermatosis after oral treatment of a presumed yeast infection with nystatin. To evaluate the reason for her diarrhea, colonoscopy was performed. The macroscopic aspect of the colon mucosa was described as normal with no specific alterations for chronic inflammatory bowel disease or for bacterial infections. In contrast, the histologic examination revealed the typical characteristics of lymphocytic colitis. This disease is thought to be caused by immunological reactions against as yet unknown luminal antigens. After treatment with steroids and dapsone the diarrhea as well as the skin disease disappeared. To our knowledge, the present report describes for the first time the association of linear IgA dermatosis with lymphocytic colitis after oral treatment with nystatin. A possible causative link between these two disease entities is discussed.
Stüber
E
E
Department of Internal Medicine, University Hospital of Kiel.
Swensson
O
O
Nitsche
R
R
Nickel
T
T
Sticherling
M
M
Christophers
E
E
Fölsch
U R
UR
D000284:Administration, Oral; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects; D001706:Biopsy; D015153:Blotting, Western; D002908:Chronic Disease; D003092:Colitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D003622:Dapsone / Q000627:therapeutic use; D003967:Diarrhea / Q000209:etiology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008775:Methylprednisolone / Q000627:therapeutic use; D009761:Nystatin / Q000008:administration & dosage / Q000009:adverse effects; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D007070:Immunoglobulin A; D009761:Nystatin; D003622:Dapsone; D008775:Methylprednisolone