Moraxella (Branhamella) catarrhalis BRO beta-lactamase: a lipoprotein of gram-positive origin?
In the past 20 years, BRO beta-lactamase-producing Moraxella catarrhalis strains have emerged. We show that BRO is expressed as a 33-kDa lipoprotein associated with the inner leaflet of the outer membrane. To our knowledge, this is the first description of a lipidated beta-lactamase in a gram-negative species.
Bootsma
H J
HJ
Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Hospital Utrecht, Utrecht, The Netherlands. H.J.Bootsma@lab.azu.nl
Aerts
P C
PC
Posthuma
G
G
Harmsen
T
T
Verhoef
J
J
van Dijk
H
H
Mooi
F R
FR
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis* / Q000276:immunology; D004926:Escherichia coli / Q000201:enzymology / Q000648:ultrastructure; D006094:Gram-Positive Bacteria / Q000737:chemistry*; D007150:Immunohistochemistry; D008074:Lipoproteins / Q000032:analysis / Q000276:immunology; D008854:Microscopy, Electron; D001936:Moraxella catarrhalis / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology; D001618:beta-Lactamases / Q000032:analysis* / Q000276:immunology
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D008074:Lipoproteins; D001618:beta-Lactamases