Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation.
An effective treatment of myeloid leukemias would rely on inducing myeloid cells to undergo differentiation. It has been demonstrated that inhibition of IMPDH with mycophenolic acid or tiazofurin resulted in inhibition of cell growth as well as induction of differentiation. We synthesized a number of bis(phosphonate) analogues of tiazofurin-, benzamide-, and mycophenolic-adenine dinucleotide which were found to be cytotoxic as well as effective inducers of cell differentiation.
Pankiewicz
K W
KW
Codon Pharmaceuticals, Inc., Gaithersburg, MD 20877, USA.
Lesiak-Watanabe
K
K
D000227:Adenine Nucleotides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002454:Cell Differentiation / Q000187:drug effects*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology; D009173:Mycophenolic Acid / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000227:Adenine Nucleotides; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009943:Organophosphorus Compounds; D007168:IMP Dehydrogenase; D009173:Mycophenolic Acid