Pharmacokinetic characteristics of minocycline in debilitated elderly patients.
A pharmacokinetic study of minocycline was performed in 12 debilitated elderly patients who had suffered from acute bacterial respiratory infections. Serial intravenous administrations of 100 mg minocycline were performed at least 10 times (infused for 1 hour, every 12 hours). Blood samples were obtained at 0, 1, 3, and 10 hours after initiating the first and fifth dose and 1 hour after the ninth dose (total, 9 points). The serum concentrations of unchanged minocycline were measured using high-performance liquid chromatography. The obtained data were analyzed using a two-compartment model in 11 cases and a one-compartment model in 1 case. Other clinical data were also collected simultaneously. The mean age of the subjects was 82 +/- 6 years. The elimination half-lives at beta-phase averaged 25.0 +/- 16.4 hours, the volume of distribution averaged 32.9 +/- 13.4 L, and the total clearance averaged 1.14 +/- 0.49 L/h. The correlation coefficient between the expected trough concentration of minocycline in steady-state and the dose per 1 kg body weight was.54 (P =.06), suggesting that dosage should be adjusted by body weight when administered to debilitated elderly patients. The present data are considered to be important and clinically useful because little information is available concerning the pharmacokinetics of minocycline in elderly patients.
Yamamoto
T
T
Medical Research Institute, Tokyo Medical and Dental University, Tokyo.
Takano
K
K
Matsuyama
N
N
Koike
Y
Y
Minshita
S
S
Sanaka
M
M
Kuyama
Y
Y
Yamakana
M
M
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism*; D013223:Statistics as Topic; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008911:Minocycline