[The future of antifungal agents. Non azole antifungal agents].
We investigated the efficacy of non-azole antifungal agents. Long circulating immunoliposomal amphotericin B was potent in murine invasive pulmonary aspergillosis. The concentration of AMPH-B was still high in the lung after 6 hours of 34A-PEG-liposomal AMPH-B. Lipid nanosphere amphotericin B (NS-718) showed efficacy against pulmonary aspergillosis in rats and pulmonary cryptococcosis in mice. The renal toxicity of NS-718 was estimated to be lower than that of AMPH-B from the results of the toxicity study in the rat infusion model. FK 463, a novel (1,3)-beta-D-glucan synthase inhibitor, showed efficacy against azole-resistant Candida albicans in murine experimental disseminated candidiasis. FK463 could be a promising drug and the therapy of choice for azole resistant C. albicans infection.
Maesaki
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto Nagasaki 852-8501.
Hossain
M A
MA
Sasaki
E
E
Hashiguchi
K
K
Higashiyama
Y
Y
Yoshitsugu
Y
Y
Tomono
K
K
Tashiro
T
T
Kohno
S
S
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology; D004337:Drug Carriers; D054714:Echinocandins; D005437:Flucytosine; D005658:Fungi / Q000201:enzymology; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology; D008081:Liposomes; D008565:Membrane Proteins; D000077551:Micafungin; D051379:Mice; D009181:Mycoses / Q000188:drug therapy; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D029702:Schizosaccharomyces pombe Proteins
D000935:Antifungal Agents; D004337:Drug Carriers; D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D008081:Liposomes; D008565:Membrane Proteins; D010456:Peptides, Cyclic; D029702:Schizosaccharomyces pombe Proteins; D000666:Amphotericin B; D005437:Flucytosine; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase; D000077551:Micafungin