title: R5 strains of human immunodeficiency virus type 1 from rapid progressors lacking X4 strains do not possess X4-type pathogenicity in human thymus.
abstract: Some individuals infected with only R5 strains of human immunodeficiency virus type 1 progress to AIDS as quickly as individuals harboring X4 strains. We determined that three R5 viruses were much less pathogenic than an X4 virus in SCID-hu Thy/Liv mice, suggesting that R5 virus-mediated rapid disease progression is associated with host, not viral, factors.
authors.affiliation: Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Berkowitz
authors.forename: A B
authors.initials: AB
authors.lastname: van't Wout
authors.forename: N A
authors.initials: NA
authors.lastname: Kootstra
authors.forename: M E
authors.initials: ME
authors.lastname: Moreno
authors.forename: V D
authors.initials: VD
authors.lastname: Linquist-Stepps
authors.forename: C
authors.initials: C
authors.lastname: Bare
authors.forename: C A
authors.initials: CA
authors.lastname: Stoddart
authors.forename: H
authors.initials: H
authors.lastname: Schuitemaker
authors.forename: J M
authors.initials: JM
authors.lastname: McCune
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D013950:Thymus Gland / Q000821:virology*