The epidemiological impact of antimeningococcal B vaccination in Cuba.
The incidence of invasive meningococcal disease (IMD) before (1984-1988) and after (1989-1994), a nationwide intervention with VA-MENGOC-BC vaccination started in 1989, was compared. The prevaccination period incidence density (ID> 8.8/10(5) year-person) was higher than the postvaccination ID (ID< 6.5/10(5) year-person). The percentage proportional differences from the start to the end of each period of ID in the vaccinal period was higher (87%) than the prevaccinal (37%) with significant differences among vaccinated groups (< 25 years old). A break-point (Chow test) was confirmed by the decrease in the ID between 1989 and 1990 in children under 1 year old, 5-9, 10-14, 15-19 and 50-54 years. Comparison of ID using maps showed a decrease in IMD in all municipalities during the postvaccination period. These findings support the epidemiological impact of VA-MENGOC-BC vaccination in the reduction of IMD morbidity.
Rodriguez
A P
AP
Instituto de Medicina Tropical 'Pedro Kourí', La Habana, Cuba. antonio@ipk.sld.cu
Dickinson
F
F
Baly
A
A
Martinez
R
R
D000293:Adolescent; D017677:Age Distribution; D000368:Aged; D001428:Bacterial Vaccines / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003462:Cuba / Q000453:epidemiology; D016021:Epidemiologic Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000276:immunology; D008589:Meningococcal Infections / Q000517:prevention & control*; D022401:Meningococcal Vaccines; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000276:immunology*; D012111:Residence Characteristics; D014611:Vaccination
D001428:Bacterial Vaccines; D022401:Meningococcal Vaccines