title: The effects of target and distractor familiarity on visual search in de novo Parkinson's disease patients: latent inhibition and novel pop-out.
abstract: De novo Parkinson's disease (PD) patients identified presence or absence of a unique shape presented with homogeneous distractors. Response time (RT) was examined as a function of prior experience with target and/or distractor assessing latent inhibition (LI; slower RTs to a target that was formerly a distractor against a background of distractors that were formerly targets as compared with a novel target with distractors that were formerly targets) and novel pop-out effects. PD patients were slower than controls in detecting test-phase targets compared with preexposure-phase targets. Female PD patients with right-side motor symptoms had elevated LI compared with female controls and female PD patients with left-side symptoms. Male PD patients with right-side symptoms did not exhibit LI. Results are discussed in terms of the dopamine hypothesis and the reciprocal relationship between PD and schizophrenia.
authors.affiliation: Department of Psychology, Tel Aviv University, Ramat Aviv, Israel. lubow@freud.tau.ac.il
authors.forename: R E
authors.initials: RE
authors.lastname: Lubow
authors.forename: R
authors.initials: R
authors.lastname: Dressler
authors.forename: O
authors.initials: O
authors.lastname: Kaplan
mesh_terms: D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014796:Visual Perception / Q000502:physiology*