[Allograft of frozen nerve in repairing sensory nerve defect].
To observe the effect of allogenic transplantation of deep frozen nerve in repairing sensory nerve defect, 22 patients who had received this type of treatment were followed up for 0.5-5 years. There were 18 males and 4 females in this group, and the average age was 28 years old. Thirty-six nerve defects including the common volar digital nerve, proper volar digital nerve were repaired by allograft of nerves stored at deep frozen (-80 degrees C). The storation period was ranged from 9 days to 1 years. The length of the nerves were 2 cm-12 cm. After follow-up for 3 years (ranged from 7 months-5 years), 23 cases of nerve allograft obtained excellent and good results (63.9%), 10 cases were fair (27.7%) and 3 cases were poor (8.3%). It was concluded that (1) frozen nerve is one of nice materials for repairing the nerve defect (< 5 cm); (2) the immunity of allogenenic nerve is weak; (3) the deep frozen storation can reduce the immunity of nerve; (4) the dimethyl sulfoxide can prevent the nerve tissue from injury by deep frozen; (5) the best temperature and period for deep frozen storation should be studied further.
Tian
L
L
Department of Hand Surgery, Affilicated Centre Hospital of Shenyang Medical College, Shenyang, P.R. China.
Zhan
J
J
Wang
S
S
D000293:Adolescent; D000328:Adult; D015925:Cryopreservation; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods; D005385:Fingers / Q000294:innervation* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009417:Nerve Tissue / Q000637:transplantation; D009926:Organ Preservation; D010525:Peripheral Nerves / Q000601:surgery*; D012584:Sciatic Nerve / Q000637:transplantation; D011984:Sensory Receptor Cells; D013979:Tibial Nerve / Q000637:transplantation