Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations.
The case is presented of a man with allergic contact dermatitis and occupational asthma due to triglycidylisocyanurate (TGIC), which is used as a hardener in thermosetting powder paint. The contact dermatitis was confirmed by patch testing (TGIC 0.5% and 5% in petrolatum), and the occupational asthma was confirmed by bronchial provocation testing: two challenges to an aerosol of lactose containing TGIC (0.05% and 0.1%, w/w, each for 0.5+1+2+4 min) led to a maximal decrease in FEV1 of 22% and 31% after 6 and 4 h, respectively. Skin prick tests with unconjugated TGIC were possibly positive. This case confirms that exposure to TGIC in powder paints may cause not only contact dermatitis, but also occupational asthma.
Meuleman
L
L
Department of Dermatology, University Hospital, K.U. Leuven, Belgium.
Goossens
A
A
Linders
C
C
Rochette
F
F
Nemery
B
B
D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D001985:Bronchial Provocation Tests; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D010328:Patch Tests; D014227:Triazines / Q000009:adverse effects*
D014227:Triazines; C028786:teroxirone