Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support.
A general method was developed to generate six-membered cyclic thiazinanes on solid support. Three diversity sites were introduced into this scaffold using primary amines, aldehydes, and 2-bromoalkanoic acids. The methodology to prepare individual cyclic thiazinanes as well as combinatorial libraries of these compounds is described.
Mortezaei
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Affymax Research Institute, Santa Clara, CA 95051, USA. reza_mortezaei@affymax.com
Ida
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Campbell
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DA
D000478:Alkylation; D016208:Databases, Factual; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D013843:Thiazines