Association of estrogen receptor gene polymorphisms with endometriosis.
OBJECTIVE
To explore the association of the estrogen receptor two-allele (point) polymorphism and multiallele (microsatellite) polymorphism with endometriosis.


METHODS
Case-control study.


METHODS
Genetics and Endoscopy Unit, Department of Obstetrics and Gynecology, Ioannina University HOSPITAL, Ioannina, Greece.


METHODS
Fifty-seven women with surgically and histologically diagnosed endometriosis of stages I-IV.


METHODS
Diagnostic laparoscopy.


METHODS
Frequency and distribution of the estrogen receptor gene polymorphisms.


RESULTS
There was a statistically significant difference between the patients and the controls in the frequency of the two-allele Pvu II polymorphism (0.72 vs. 0.49) and in the median repeats of the (TA)n multiallele polymorphism (15 vs. 20 repeats). In both groups, linkage was found between the fewer (TA)n repeats (range, 12-19) and the positive Pvu II polymorphism.


CONCLUSIONS
The variability of the estrogen receptor gene likely contributes to the pathogenesis of endometriosis.
Georgiou
I
I
Department of Obstetrics and Gynecology, Ioannina University Hospital and Ioannina University Medical School, Greece.
Syrrou
M
M
Bouba
I
I
Dalkalitsis
N
N
Paschopoulos
M
M
Navrozoglou
I
I
Lolis
D
D
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
D011960:Receptors, Estrogen