title: Effects of short courses of different doses of prednisone and dexamethasone on serum third component of complement (C3) levels in dogs.
abstract: The effect of different doses of prednisone and dexamethasone on serum C3 levels was determined in 35 dogs. Dogs in Group A (n = 15) were administered prednisone (1.1 mg/kg/day) for 14 days; dogs in Group B (n = 10) were given prednisone at 2.2 mg/kg/day for 7 days; dogs in group C (n = 10) were administered dexamethasone (0.25 g/kg/day) for 7 days. Serum C3 concentrations were determined using a sandwich ELISA in samples obtained before and after glucocorticoid administration. Concentrations were expressed as a percentage of a reference standard. No statistically significant differences were found after glucocorticoid administration in all groups. Thus, short-term administration of prednisone and dexamethasone at commonly used doses did not result in significantly lower serum C3 levels.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Córdoba, Spain. pv2lusor@lucano.uco.es
authors.forename: R
authors.initials: R
authors.lastname: Lucena
authors.forename: P J
authors.initials: PJ
authors.lastname: Ginel
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: M
authors.initials: M
authors.lastname: Novales
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003176:Complement C3 / Q000378:metabolism*; D003907:Dexamethasone / Q000008:administration & dosage*; D004285:Dogs / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D008297:Male; D011241:Prednisone / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D003176:Complement C3; D003907:Dexamethasone; D011241:Prednisone