title: Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells.
abstract: We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
authors.affiliation: Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. aslomin@wpo.it.luc.edu
authors.forename: A
authors.initials: A
authors.lastname: Slominski
authors.forename: C E
authors.initials: CE
authors.lastname: Gomez-Sanchez
authors.forename: M F
authors.initials: MF
authors.lastname: Foecking
authors.forename: J
authors.initials: J
authors.lastname: Wortsman
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000096:biosynthesis; D000804:Angiotensin II / Q000494:pharmacology; D003345:Corticosterone / Q000096:biosynthesis*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D006801:Humans; D007700:Kinetics; D008545:Melanoma / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000804:Angiotensin II; C042509:18-hydroxydeoxycorticosterone; D003900:Desoxycorticosterone; D000450:Aldosterone; D011374:Progesterone; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone