title: A 'de novo' arisen case of angioedema C1-inhibitor deficiency dependent: possible mutagenic effect of azathioprine?
abstract: It is reported that a C1-inhibitor (CI-INH) deficiency dependent angiodema case arose 'de novo' in a child without a family history of this disease. His mother was undergoing immunosuppressive therapy (50 mg of azathioprine plus 8 mg of methyl-prednisolone daily) during pregnancy, uninterrupted for seven years because of a kidney transplant. All the other known causes of acquired C1-INH deficiency were excluded. An involvement of an azathioprine-induced C1-INH gene mutation is hypothised.
authors.forename: S
authors.initials: S
authors.lastname: Guastafierro
authors.forename: A
authors.initials: A
authors.lastname: D'Apuzzo
authors.forename: G
authors.initials: G
authors.lastname: Verrazzo
authors.forename: G
authors.initials: G
authors.lastname: Lucivero
authors.forename: L
authors.initials: L
authors.lastname: Coppola
mesh_terms: D000799:Angioedema / Q000139:chemically induced* / Q000503:physiopathology; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001379:Azathioprine / Q000009:adverse effects*; D002675:Child, Preschool; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency*; D050718:Complement C1 Inhibitor Protein; D005260:Female; D006801:Humans; D008297:Male; D009153:Mutagens; D011247:Pregnancy
chemical_list: D000964:Antimetabolites, Antineoplastic; D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; D009153:Mutagens; D001379:Azathioprine