title: Does laparoscopic cholecystectomy influence peri-sinusoidal cell activity?
abstract: OBJECTIVE
  To investigate the influence of laparoscopic procedures on perisinusoidal cell function.
  
  
  METHODS
  In 31 patients who underwent laparoscopic cholecystectomy for symptomatic cholelithiasis, the serum levels of beta-N-acetyl hexosaminidase (beta-NAH) and hyaluronic acid (HA) were measured. Six female patients, who underwent other laparoscopic procedures, not involving the hepatobiliary system, served as controls.
  
  
  RESULTS
  HA serum levels increased significantly in both study and control groups, while beta-NAH serum levels remained within normal values. Post-operative AST and ALT serum levels increased significantly only in the study group. No elevation of serum ALP was noted in any of our patients, and post-operative bilirubin levels did not increase in patients with normal pre-operative levels.
  
  
  CONCLUSIONS
  Laparoscopic procedures caused detectable damage to Kupffer and endothelial cells as reflected by elevation of post-operative HA serum levels. The damage to the liver hepatocytes and perisinusoidal cells has no clinical significance and the laparoscopic procedure itself is the probable cause of the Kupffer and endothelial cells damage, while other mechanisms caused damage to the hepatocytes.
authors.affiliation: Department of Surgery B, Assaf Harofeh Medical Center, Zerifin, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Bendet
authors.forename: V
authors.initials: V
authors.lastname: Morozov
authors.forename: R
authors.initials: R
authors.lastname: Lavi
authors.forename: M
authors.initials: M
authors.lastname: Panski
authors.forename: A
authors.initials: A
authors.lastname: Halevy
authors.forename: E
authors.initials: E
authors.lastname: Scapa
mesh_terms: D000328:Adult; D000368:Aged; D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000201:enzymology / Q000601:surgery*; D004730:Endothelium, Vascular / Q000201:enzymology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007728:Kupffer Cells / Q000201:enzymology; D008111:Liver Function Tests; D008875:Middle Aged; D011183:Postoperative Complications / Q000201:enzymology*; D001619:beta-N-Acetylhexosaminidases / Q000097:blood*
chemical_list: D006820:Hyaluronic Acid; D001619:beta-N-Acetylhexosaminidases