title: The structural biology of the developing dental enamel matrix.
abstract: The biomineralization of the dental enamel matrix with a carbonated hydroxyapatite mineral generates one of the most remarkable examples of a vertebrate mineralized tissue. Recent advances in the molecular biology of ameloblast gene products have now revealed the primary structures of the principal proteins involved in this extracellular mineralizing system, amelogenins, tuftelins, ameloblastins, enamelins, and proteinases, but details of their secondary, tertiary, and quaternary structures, their interactions with other matrix and or cell surface proteins, and their functional role in dental enamel matrix mineralization are still largely unknown. This paper reviews our current knowledge of these molecules, the probable molecular structure of the enamel matrix, and the functional role of these extracellular matrix proteins. Recent studies on the major structural role played by the amelogenin proteins are discussed, and some new data on synthetic amelogenin matrices are reviewed.
authors.affiliation: Center for Craniofacial Molecular Biology, School of Dentistry, Los Angeles, California 90089, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Fincham
authors.forename: J
authors.initials: J
authors.lastname: Moradian-Oldak
authors.forename: J P
authors.initials: JP
authors.lastname: Simmer
mesh_terms: D000566:Amelogenesis; D053523:Amelogenin; D000595:Amino Acid Sequence; D000818:Animals; D003743:Dental Enamel / Q000737:chemistry* / Q000254:growth & development / Q000648:ultrastructure*; D003746:Dental Enamel Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D013499:Surface Properties
chemical_list: D053523:Amelogenin; D003746:Dental Enamel Proteins; D008903:Minerals