title: [Role of proteinase inhibitors in the process that provide coupling between body's functional systems].
abstract: The authors make an attempt to substantiate the idea that proteinase inhibitors can produce a noticeable effect on the integration of functions. It is suggested that proteinase inhibitors play a special role in providing coupling between the body's functional systems in the conditions that may disturb the structural and functional integrity of the organism. They paper provides experimental evidence for the effect of the serine proteinase inhibitor alpha 1-antitrypsin on the thermal regulatory system and couples functional systems that provide behavioral responses. Possible mechanisms of systemic action of proteinase inhibitors and their involvement in the integrative activity of the nervous system are discussed.
authors.forename: V N
authors.initials: VN
authors.lastname: Gurin
authors.forename: D B
authors.initials: DB
authors.lastname: Sandakov
authors.forename: A V
authors.initials: AV
authors.lastname: Gurin
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism; D006802:Human Activities; D006801:Humans; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D000515:alpha 1-Antitrypsin / Q000494:pharmacology*
chemical_list: D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin; D010450:Endopeptidases
vernacular_title: O znachenii ingibitorov proteinaz v protsessakh, obespechivaiushchikh sopriazhenie deiatel'nosti funktsional'nykh sistem organizma.