Moyamoya disease. Report of three cases in Brazilian patients.
Moyamoya disease (MMD) is a chronic occlusive cerebrovascular disease of unknown etiology reported mainly in the Japanese. Most cases occur in children. The disease is rare in non-Oriental adults manifesting itself mostly as intracerebral hemorrhages. We describe MMD in 2 non-Oriental young adults and one adolescent that developed cerebral infarctions. The adults were medicated with aspirin and no medication was given to the adolescent. All patients did not deteriorate in a follow-up period from 1 to 4 years. Although rare, MMD is an important cause of stroke in young individuals and may well be underreported: only 18 patients have been reported till 1997 in Brazil. Neurologists should include MMD in differential diagnosis of ischemic and hemorrhagic strokes in young adults.
Franco
C M
CM
Department of Neurology and Neurosurgery, Universidade Federal de São Paulo-Escola Paulista de Medicina (UNIFESP-EPM), Brazil. clelia@unisys.com.br
Fukujima
M M
MM
de Oliveira
R de M
Rde M
Gabbai
A A
AA
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D001938:Brazil; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009072:Moyamoya Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011859:Radiography
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin