title: Prostaglandin E1 for renal papillary necrosis in a patient with diabetes mellitus.
abstract: We report a case of renal papillary necrosis with diabetes mellitus which was treated with prostaglandin E1. An intravenous infusion of 40 mg/day prostaglandin E1 was given for 14 days in an attempt to improve renal circulation. Treatment resulted in an improved creatinine clearance, renal plasma flow and renogram, and proteinuria was decreased. The administration of prostaglandin E1 produced an improvement in renal haemodynamics and can be considered as a possible therapy for renal papillary necrosis in diabetic patients.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Ozono
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: A
authors.initials: A
authors.lastname: Furusu
authors.forename: K
authors.initials: K
authors.lastname: Shioshita
authors.forename: O
authors.initials: O
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Tsukasaki
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017595:Renal Plasma Flow / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D003404:Creatinine; D000527:Alprostadil