Adrenomedullin-like immunoreactivity in the rat hypothalamo-neurohypophysial tract.
Adrenomedullin-like immunoreactivity in the hypothalamo-neurohypophysial tract in colchicine-treated and hypophysectomized rats was examined by immunohistochemistry. Adrenomedullin-like immunoreactive (AM-LI) neurons were localized in the hypothalamic areas, including the paraventricular nuclei and the supraoptic nuclei. Abundant AM-LI fibers and varicosities were found in the hypothalamoneurohypophysial tract and the internal zone of the median eminence in the colchicine-treated and hypophysectomized rats, whereas in control rats few AM-LI fibers were observed. These results suggest that the axons of the AM-LI neurons in the hypothalamus may terminate in the neurohypophysis.
Ueta
Y
Y
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Hara
Y
Y
Setiadji
V S
VS
Isse
T
T
Shibuya
I
I
Kitamura
K
K
Kangawa
K
K
Matsuo
H
H
Eto
T
T
Hattori
Y
Y
Yamashita
H
H
D053607:Adrenomedullin; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D007016:Hypophysectomy; D007030:Hypothalamo-Hypophyseal System / Q000737:chemistry*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry; D010455:Peptides / Q000276:immunology / Q000302:isolation & purification*; D010904:Pituitary Gland, Posterior / Q000737:chemistry* / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000737:chemistry
D010455:Peptides; D053607:Adrenomedullin; D003078:Colchicine