[The relationship between polymorphism of LMP2 and LMP7 genes and the phenotype of ankylosing spondylitis].
OBJECTIVE
To evaluate the relationship of the polymorphism of LMP2 and LMP7 genes and the phenotype of patients with ankylosing spondylitis(AS).


METHODS
One hundred and eighteen blood samples were collected from patients with AS and acute anterior uveitis(AAU). HLA-B(27) typing was performed and LMP2 and LMP7 amplified fragment length polymorphisms were determined after PCR and digestion with Cfo I restriction enzyme in the study.


RESULTS
There was a significantly increased LMP2 BB genotype frequency in patients with AS+AAU(86.9%) and AAU(87%), compared with controls(53.3%) and AS patients(63.1%)(P<0.05); the odds ratio(OR) relating LMP2 BB and AAU was 5.83, and the OR for AS+AAU was 3.71. No difference was found between adult AS and junior AS and between AS patients with and without extraspinal arthritis. No difference was found in LMP7 genotype.


CONCLUSIONS
The polymorphism of LMP2 gene is strongly associated with the development of AAU in AS patients and in uncomplicated AAU patients, but not with the age at onset and the type of joints affected.
Ding
H
H
Arthritis Research and Clinic Center, People's Hospital, Beijing Medical University, Beijing, 100044 P.R.China. ding-haiming@hotmail.com
Lu
H
H
Jiang
D
D
Chen
Z
Z
Lin
J
J
Wang
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003546:Cysteine Endopeptidases; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009097:Multienzyme Complexes; D010641:Phenotype; D016133:Polymerase Chain Reaction; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000235:genetics*; D014763:Viral Matrix Proteins / Q000235:genetics*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D009097:Multienzyme Complexes; D011506:Proteins; D014763:Viral Matrix Proteins; D003546:Cysteine Endopeptidases; C077436:LMP7 protein; D046988:Proteasome Endopeptidase Complex