title: Dietary Approaches to Stop Hypertension: rationale, design, and methods. DASH Collaborative Research Group.
abstract: Epidemiologic studies across societies have shown consistent differences in blood pressure that appear to be related to diet. Vegetarian diets are consistently associated with reduced blood pressure in observational and interventional studies, but clinical trials of individual nutrient supplements have had an inconsistent pattern of results. Dietary Approaches to Stop Hypertension (DASH) was a multicenter, randomized feeding study, designed to compare the impact on blood pressure of 3 dietary patterns. DASH was designed as a test of eating patterns rather than of individual nutrients in an effort to identify practical, palatable dietary approaches that might have a meaningful impact on reducing morbidity and mortality related to blood pressure in the general population. The objectives of this article are to present the scientific rationale for this trial, review the methods used, and discuss important design considerations and implications.
authors.affiliation: Kaiser Permanente Center for Health Research, Honolulu, Hawaii 96813, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Vogt
authors.forename: L J
authors.initials: LJ
authors.lastname: Appel
authors.forename: E
authors.initials: E
authors.lastname: Obarzanek
authors.forename: T J
authors.initials: TJ
authors.lastname: Moore
authors.forename: W M
authors.initials: WM
authors.lastname: Vollmer
authors.forename: L P
authors.initials: LP
authors.lastname: Svetkey
authors.forename: F M
authors.initials: FM
authors.lastname: Sacks
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
authors.forename: J A
authors.initials: JA
authors.lastname: Cutler
authors.forename: M M
authors.initials: MM
authors.lastname: Windhauser
authors.forename: P H
authors.initials: PH
authors.lastname: Lin
authors.forename: N M
authors.initials: NM
authors.lastname: Karanja
mesh_terms: D000328:Adult; D001794:Blood Pressure; D004032:Diet; D014676:Diet, Vegetarian; D006801:Humans; D006973:Hypertension / Q000178:diet therapy* / Q000453:epidemiology; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012107:Research Design