title: Synthesis of alkenyl acyclonucleosides derivatives of 5-halogenouracil as antiviral and antitumoral agents.
abstract: Alkenyl acyclonucleosides derivatives of 5-halogenouracil have been synthesized via Michael addition reaction. These compounds were treated by allylbromide, propargylbromide or ethylbromoacetate to give the corresponding N-1,N-3-disubstituted 5-halogenouracil.
authors.affiliation: Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Rochdi
authors.forename: M
authors.initials: M
authors.lastname: Taourirte
authors.forename: N
authors.initials: N
authors.lastname: Redwane
authors.forename: H B
authors.initials: HB
authors.lastname: Lazrek
authors.forename: J L
authors.initials: JL
authors.lastname: Barascut
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014498:Uracil / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009705:Nucleosides; D014498:Uracil