title: Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents.
abstract: Polymer-supported reagents and sequestering agents may be used to generate an array of variously substituted hydroxamic acid derivatives as potential inhibitors of matrix metalloproteinases without any chromatographic purification step.
authors.affiliation: Department of Chemistry, University of Cambridge, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Caldarelli
authors.forename: J
authors.initials: J
authors.lastname: Habermann
authors.forename: S V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods; D006877:Hydroxamic Acids / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D061965:Matrix Metalloproteinase Inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D011108:Polymers / Q000737:chemistry; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D011719:Pyrazines; D013449:Sulfonamides
chemical_list: C097658:CGS 27023A; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D061965:Matrix Metalloproteinase Inhibitors; D011108:Polymers; D011480:Protease Inhibitors; D011719:Pyrazines; D013449:Sulfonamides; D008666:Metalloendopeptidases