[Hepatitis G virus infection in hemodialyzed children and adults following kidney transplantation].
Recently, a new human virus hepatitis G virus was identified. The aim of the present study was to use a combination of the reverse transcription-polymerase chain reaction and a new test for antibodies to the viral envelope protein E2 to assess the prevalence of hepatitis G virus infection in sera of children and adults treated with hemodialysis or peritoneal dialysis as well as in sera of those who underwent renal transplantation. Hepatitis G virus RNA prevalence was higher in the shole group of patients with renal failure than in control group. The difference between hepatitis RNA prevalence in transplanted group and in control group was found to be significant. Anti-E2, which are is considered as an indicator of a past hepatitis G virus infection, were detected in the similar rate in the treated and control subjects. Time on hemodialysis was significantly longer in hepatitis G virus infected patients as compared to uninfected patients and all patients with hepatitis G virus RNA have a history of blood transfusions. Patients with renal failure treated with dialysis or subjected to renal transplantation are at increased risk of acquiring the hepatitis G virus infection. Higher rates of the hepatitis G virus RNA and similar prevalence of anti-E2 in patients with renal failure as compared to controls suggest that the rate of hepatitis G virus infection resolution in immunosuppressed patients with renal failure might be lower than in immunocompetent subjects.
Szabó
A
A
I. sz. Gyermekklinika, Semmelweis Orvostudományi Egyetem, Budapest.
Heemann
U
U
Müller
V
V
Reusz
G
G
Sallay
P
P
Viazov
S
S
Tulassay
T
T
D000293:Adolescent; D000328:Adult; D002648:Child; D018067:Flaviviridae / Q000302:isolation & purification*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011183:Postoperative Complications / Q000821:virology; D006435:Renal Dialysis
Hepatitis G vírus infekció vesetranszplantált és dializált gyermek és felnött betegekben.