Neurodegenerative diseases of Guam: analysis of TAU.
Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam.
Pérez-Tur
J
J
Mayo Clinic Department of Pharmacology, Jacksonville, FL 32224, USA.
Buée
L
L
Morris
H R
HR
Waring
S C
SC
Onstead
L
L
Wavrant-De Vrièze
F
F
Crook
R
R
Buée-Scherrer
V
V
Hof
P R
PR
Petersen
R C
RC
McGeer
P L
PL
Delacourte
A
A
Hutton
M
M
Siddique
T
T
Ahlskog
J E
JE
Hardy
J
J
Steele
J C
JC
D000368:Aged; D000369:Aged, 80 and over; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D003704:Dementia / Q000150:complications / Q000235:genetics*; D005260:Female; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins