Effect of diethylstilbestrol on reproductive function.
OBJECTIVE
To review the effects of in utero exposure to diethylstilbestrol (DES) on müllerian development and subsequent reproductive function.


METHODS
The literature on DES and reproductive function was reviewed and summary data are presented. The studies were identified through the computerized MEDLINE database and a manual search of relevant bibliographies.


RESULTS
In utero exposure to DES resulted in reduced fertility and increased rates of ectopic pregnancy, spontaneous abortion, and preterm delivery.


CONCLUSIONS
An understanding of the reproductive performance of women who were exposed to DES in utero is useful for counseling these patients regarding their risks and treatment options.
Goldberg
J M
JM
Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Ohio 44195, USA. goldbej@cesmtp.ccf.org
Falcone
T
T
D004054:Diethylstilbestrol / Q000009:adverse effects*; D005187:Fallopian Tubes / Q000002:abnormalities; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced / Q000453:epidemiology / Q000628:therapy; D005836:Genitalia, Female / Q000002:abnormalities; D006801:Humans; D009095:Mullerian Ducts / Q000187:drug effects; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000453:epidemiology / Q000628:therapy; D018873:Pregnancy Rate; D011297:Prenatal Exposure Delayed Effects; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000002:abnormalities
D004054:Diethylstilbestrol