title: IFN gamma inhibits porcine reproductive and respiratory syndrome virus replication in macrophages.
abstract: This study reports the effect of IFN gamma on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFN gamma profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFN gamma on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFN gamma may play an important role in protection.
authors.affiliation: Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Bautista
authors.forename: T W
authors.initials: TW
authors.lastname: Molitor
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000502:physiology*; D011994:Recombinant Proteins; D013552:Swine / Q000821:virology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011994:Recombinant Proteins; D007371:Interferon-gamma