title: Synthesis, toxicological, and pharmacological assessment of some oximes and aldehyde condensation products of 4-hydroxycoumarin.
abstract: The synthesis of condensation products of 4-hydroxycoumarin and nitro-substituted aromatic aldehydes as well as oximes of drugs with anticoagulant activity is described. The acute toxicity of the compounds was studied in mice by oral and intraperitoneal administration. A comparative pharmacological study of the in vivo anticoagulant effects of Warfarin derivatives showed that the new compounds have different anticoagulant activity. 4-Hydroxy-3-[1- (4-chlorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one, oxime 3 showed anticoagulant effect similar to Warfarin and Coumachlor, but its acute toxicity was higher than that of the reference drugs.
authors.affiliation: Department of Industrial Pharmacy, Faculty of Pharmacy, St. Sofia, Bulgaria.
authors.forename: I
authors.initials: I
authors.lastname: Manolov
authors.forename: N D
authors.initials: ND
authors.lastname: Danchev
mesh_terms: D015110:4-Hydroxycoumarins; D000447:Aldehydes; D000818:Animals; D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice; D010091:Oximes; D014859:Warfarin / Q000494:pharmacology / Q000633:toxicity
chemical_list: D015110:4-Hydroxycoumarins; D000447:Aldehydes; D000925:Anticoagulants; D010091:Oximes; D014859:Warfarin; C068805:4-hydroxycoumarin