Synthesis and antiviral activity of L-2'-deoxy-2'-up-fluoro-4'-thionucleosides.
L-2'-Deoxy-2'-up-fluoro-4'-thionucleosides were efficiently synthesized from D-xylose via L-4-thioarabitol derivative as a key intermediate and evaluated for antiviral activities against HIV-1, HSV-1,2 and HBV.
Jeong
L S
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Moon
H R
HR
Yoo
S J
SJ
Lee
S N
SN
Kim
H D
HD
Chun
M W
MW
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D013872:Thionucleosides