title: Tumid lupus erythematosus.
abstract: BACKGROUND
  Tumid lupus erythematosus (TLE) is a subtype of discoid lupus erythematosus (DLE) whose clinical characteristics rarely have been described in the literature.
  
  
  OBJECTIVE
  To describe the clinical, histopathologic, and other laboratory findings in tumid lupus erythematosus.
  
  
  METHODS
  Clinical and laboratory findings were reviewed in four patients who had been diagnosed with tumid lupus erythematosus by conventional microscopy. The diagnoses were characterized by a superficial and deep perivascular infiltrate of lymphocytes and deposits of mucin in foci in the reticular dermis.
  
  
  RESULTS
  All four patients were young women. Ages ranged from 16 to 39 years (mean 21 years). The lesions consisted of numerous erythematous papules and plaques, some with annular configuration situated in the face and neck, trunk, and upper extremities. All four patients had concurrent lesions of classic DLE, three of them had systemic lupus erythematosus (SLE). Direct immunofluorescence test results were negative in nonexposed lesional skin of two of the patients.
  
  
  CONCLUSIONS
  The clinical findings of concurrent lesions of TLE and classic DLE in the same patient, the presence of lesions of TLE in patients with SLE, and the histologic findings demonstrate that TLE is a distinct manifestation of DLE, and as such, a cutaneous expression of SLE.
authors.affiliation: University of Puerto Rico, School of Medicine, Department of Dermatology, San Juan 00936-5067, USA.
authors.forename: H
authors.initials: H
authors.lastname: Ruiz
authors.forename: J L
authors.initials: JL
authors.lastname: Sánchez
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D009077:Mucins / Q000378:metabolism
chemical_list: D009077:Mucins