Pharmacokinetic profile and adverse gastric effect of zinc-piroxicam in rats.
Complexation of piroxicam with zinc extends its absorption time in rats. The time of peak concentration value for complexed piroxicam was 5.27 hr compared to only 2.56 hr for the uncomplexed agent. Piroxicam and zinc-piroxicam show similar inhibitory effects on carrageenin-induced paw edema. Zinc-piroxicam is less irritating than piroxicam on the gastric mucosa.
Tagliati
C A
CA
Depto. de Análises Clínicas e Toxicológicas da Faculdade de Farmácia da Universidade Federal de Minas Gerais, Brazil.
Kimura
E
E
Nothenberg
M S
MS
Santos
S R
SR
Oga
S
S
D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000009:adverse effects / Q000493:pharmacokinetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000493:pharmacokinetics*; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000493:pharmacokinetics*; D002351:Carrageenan / Q000494:pharmacology; D004359:Drug Therapy, Combination; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005753:Gastric Mucosa / Q000378:metabolism*; D006614:Hindlimb; D008297:Male; D010894:Piroxicam / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000473:pathology
D000614:Aminocaproates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010894:Piroxicam; C018802:6-acetylaminocaproic acid; D002351:Carrageenan; D015119:Aminocaproic Acid