title: Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia.
abstract: Zhenxuanyin [symbol: see text] is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes' complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03 g/kg, 0.3 g/kg, 1 g/kg, or 3 g/kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3 g/kg can increase cerebral blood flow (CBF) to the normal level.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Jingyi
authors.forename: M
authors.initials: M
authors.lastname: Yasuhiro
authors.forename: H
authors.initials: H
authors.lastname: Naoya
authors.forename: R C
authors.initials: RC
authors.lastname: Seok
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshiharu
authors.forename: T
authors.initials: T
authors.lastname: Nagara
authors.forename: T
authors.initials: T
authors.lastname: Fumiko
authors.forename: M
authors.initials: M
authors.lastname: Shigeru
authors.forename: K
authors.initials: K
authors.lastname: Junji
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D020367:Iofetamine; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014715:Vertebrobasilar Insufficiency / Q000503:physiopathology*
chemical_list: D004365:Drugs, Chinese Herbal; D020367:Iofetamine