Secretory immunoglobulin A and cardiovascular reactions to mental arithmetic, cold pressor, and exercise: effects of beta-adrenergic blockade.
We investigated the influence of sympathetic nervous system processes on mucosal immunity by comparing the effects of beta-adrenoceptor blockade with 40 mg propranolol and placebo on secretory immunoglobulin A (sIgA) at rest and during paced serial arithmetic, cold pressor, and submaximal cycling. These tasks produced patterns of cardiovascular activity indicative of combined alpha- and beta-adrenergic, alpha-adrenergic, and beta-adrenergic activation, respectively. The effectiveness of the beta blockade was confirmed by the attenuation under propranolol of the shortening of the cardiac preejection period and the tachycardia elicited by mental arithmetic and exercise. The cold pressor test did not affect sIgA under either the placebo or the propranolol. Mental arithmetic increased sIgA concentration, and this increase was not blocked by propranolol. Exercise elicited increases in both sIgA concentration and sIgA secretion rate, which were not diminished by beta blockade. These data suggest that sIgA is not regulated by beta-adrenergic mechanisms.
Winzer
A
A
School of Sport and Exercise Sciences, University of Birmingham, UK.
Ring
C
C
Carroll
D
D
Willemsen
G
G
Drayson
M
M
Kendall
M
M
D000319:Adrenergic beta-Antagonists; D000328:Adult; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D003080:Cold Temperature; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011340:Problem Solving / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013312:Stress, Physiological / Q000276:immunology* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D007071:Immunoglobulin A, Secretory; D011943:Receptors, Adrenergic, beta