Cellular changes in rat brain areas associated with neonatal hippocampal damage.
The neonatal destruction of the ventral hippocampus was introduced as a model to recreate features of schizophrenia in the rat. While behavioral consequences of this intervention have been studied in detail, less is known about the cellular processes underlying the deviant behavior. We studied in rats (neonatally or adult lesioned, controls) brain areas receiving or not receiving hippocampal projections. The number of neurons and the expression of the cell markers L-ornithine decarboxylase, nitric oxide synthase/NADPH diaphorase, calretinin and GFAP were estimated. Reduced numbers of neurons and increased immunostaining for ornithine decarboxylase and nitric oxide synthase in the prefrontal, perirhinal and entorhinal cortex of neonatally but not adult lesioned rats or controls demonstrate persistent cellular changes after ventral hippocampus damage.
Bernstein
H G
HG
Department of Psychiatry, University of Magdeburg, Germany.
Grecksch
G
G
Becker
A
A
Höllt
V
V
Bogerts
B
B
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology*; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001927:Brain Diseases / Q000139:chemically induced / Q000473:pathology*; D064032:Calbindin 2; D018690:Excitatory Amino Acid Agonists; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006624:Hippocampus / Q000473:pathology*; D007051:Ibotenic Acid; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I; D009955:Ornithine Decarboxylase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
C576512:Calb2 protein, rat; D064032:Calbindin 2; D018690:Excitatory Amino Acid Agonists; D005904:Glial Fibrillary Acidic Protein; D064030:S100 Calcium Binding Protein G; D007051:Ibotenic Acid; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496322:Nos1 protein, rat; D009252:NADPH Dehydrogenase; D009955:Ornithine Decarboxylase