title: Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum.
abstract: OBJECTIVE
  This study investigates the effect of fosfomycin on the tumoricidal efficacy of cisplatinum.
  
  
  METHODS
  Prospective study utilizing the FaDu squamous cell carcinoma cell line and a nude mouse tumor xenograft model.
  
  
  METHODS
  Tumor cell growth was assessed in vitro in the presence of cisplatinum and/or fosfomycin utilizing the MTT assay. An optimal cisplatinum dose and dosing schedule was established in a nude mouse tumor xenograft model of squamous cell carcinoma. Using this model, fosfomycin was tested at three dosages and tumor growth monitored over 4 weeks.
  
  
  RESULTS
  Mice treated with cisplatinum and fosfomycin had smaller tumors than those treated with cisplatinum alone (P<.01).
  
  
  CONCLUSIONS
  This study is the first demonstration that fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum in vivo. This suggests that fosfomycin may be useful in preventing cisplatinum-induced ototoxicity and nephrotoxicity in humans without altering the tumor response rate.
authors.affiliation: University of Texas Southwestern, Department of Otolaryngology, Dallas, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Jordan
authors.forename: N D
authors.initials: ND
authors.lastname: Schwade
authors.forename: J M
authors.initials: JM
authors.lastname: Truelson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005578:Fosfomycin / Q000494:pharmacology*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000517:prevention & control; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011446:Prospective Studies; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D002945:Cisplatin