Fetal middle-cerebral and umbilical artery flow assessments after glucose challenge test.
OBJECTIVE
To determine whether a change occurs in fetal middle-cerebral and umbilical artery flow after glucose challenge testing.


METHODS
Fetal middle-cerebral and umbilical artery flow was assessed by Color Dopppler technology in 21 pregnant patients before and after the 50-g glucose challenge test. The resistance index (IR) was evaluated separately for each vessel. Statistical significance was determined by Chi-square test and repeated measurement analysis with two co-variates.


RESULTS
After glucose ingestion the RI was significantly decreased in the middle-cerebral artery, but not in the umbilical artery. A significant increase in RI was recorded in the umbilical artery when maternal plasma glucose level exceeded 102 mg%.


CONCLUSIONS
Maternal ingestion of glucose significantly alters blood flow velocimetry in the fetal middle-cerebral and umbilical arteries. These changes may lead to the misinterpretation of normal results. It is therefore recommended that sonographic flow velocimetry assessment not be performed early after concentrated glucose ingestion.
Pardo
J
J
Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
Orvieto
R
R
Rabinerson
D
D
Bar
J
J
Hod
M
M
Kaplan
B
B
D000328:Adult; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000502:physiology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000502:physiology; D016009:Chi-Square Distribution; D005314:Embryonic and Fetal Development; D005260:Female; D005951:Glucose Tolerance Test; D018056:Hemorheology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy / Q000502:physiology*; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging* / Q000502:physiology
D001786:Blood Glucose