Plasma endothelin-1 elevation associated with alcohol-induced variant angina.
Vasospastic angina as a result of alcohol ingestion has been reported, but the mechanism of alcohol-induced coronary artery spasm is presently unknown. This report presents 2 cases of alcohol-induced variant angina (VA) with elevated levels of plasma endothelin-1 after alcohol ingestion. In case 1, the plasma endothelin-1 concentration was 3.15 pg/ml before drinking (normal <2.30 pg/ml) and increased to 4.09 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 2.88 pg/ml and 6 months after abstinence, it decreased to 2.03 pg/ml (normal range). In case 2, the plasma endothelin-1 concentration was 2.44 pg/ml before drinking and increased to 4.36 pg/ml when measured 5 h after alcohol ingestion. After 2 months of abstinence, the plasma endothelin-1 concentration was 3.04 pg/ml and 6 months after abstinence, it decreased to 2.09 pg/ml (normal range). These 2 cases suggest that a relationship may exist between alcohol-induced VA and elevation in the plasma endothelin-1 concentration after alcohol ingestion.
Kaku
B
B
Fukui Cardiovascular Center, Shinbo, Japan.
Mizuno
S
S
Ohsato
K
K
Murakami
T
T
Moriuchi
I
I
Arai
Y
Y
Nio
Y
Y
Ohe
K
K
Mabuchi
T
T
Takahashi
Y
Y
Ohnaka
M
M
D000368:Aged; D000434:Alcoholic Beverages / Q000009:adverse effects*; D000788:Angina Pectoris, Variant / Q000097:blood* / Q000139:chemically induced / Q000209:etiology*; D002637:Chest Pain / Q000139:chemically induced; D017023:Coronary Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced; D004562:Electrocardiography; D019332:Endothelin-1 / Q000097:blood* / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013695:Temperance; D013997:Time Factors
D019332:Endothelin-1; D000431:Ethanol