title: TNM staging, histopathological grading, and tumor-associated antigens in patients with a history of mucoepidermoid carcinoma of the salivary glands.
abstract: BACKGROUND
  The aim of this study was to evaluate the TNM categories and histopathological grading as prognostic factors in mucoepidermoid carcinoma (MEC). In addition, the study was designed to provide baseline data on levels of tumor-associated antigens (TAA) in sera of MEC patients.
  
  
  METHODS
  Fifty-nine patients with MEC of the salivary glands were evaluated.
  
  
  RESULTS
  Reclassified TNM stage, at the time of initial diagnosis, varied considerably. In disease-free patients, none of the tested sera were TAA elevated above the cut-off levels. Our patients who died of tumor metastasis had all been classified as stage III or IV at the time of initial diagnosis. Distant metastases are rarely found even decades after surgical therapy.
  
  
  CONCLUSIONS
  Long-term follow-up is recommended for patients with MEC of the salivary glands. TAA are not elevated in disease-free patients. The value of TAA in the monitoring of MEC patients remains to be evaluated in further studies.
authors.affiliation: Oral and Maxillofacial Surgery Clinic, Eppendorf University Hospital, University of Hamburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Plambeck
authors.forename: R E
authors.initials: RE
authors.lastname: Friedrich
authors.forename: M
authors.initials: M
authors.lastname: Bahlo
authors.forename: S
authors.initials: S
authors.lastname: Bartel-Friedrich
authors.forename: R
authors.initials: R
authors.lastname: Klapdor
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018277:Carcinoma, Mucoepidermoid / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000145:classification / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor