[Effect of acute moderate isovolumic hemodilution on the pharmacokinetics of vecuronium].
OBJECTIVE
To determine the effect of acute moderate isovolemic hemodilution on pharmacokinetics of vecuronium.


METHODS
Twenty-six adult patients, ASA grade I, undergoing elective plastic surgery, were randomly divided equally into the control and hemodilution group. The blood samples were taken for 5 hours following intravenous bolus of 100 micrograms/kg of vecuronium in two groups. The plasma concentrations of vecuronium were determined with an improved fluorometry and the pharmacokinetic parameters were obtained by fitting the data with a 3P87 program.


RESULTS
The disposition of vecuronium can be best described by a three compartment open model. As comparison with the control group, the values of Vc and Vdss in hemodilution group were greater than that in the control, while T1/2 beta was markedly prolonged in this group. There were no significant differences in T1/2 phi, T1/2 alpha, K12, K21, K13, K31, K10, MRT, AUC, and Cl between the two groups.


CONCLUSIONS
Acute moderate isovolemic hemodilution could change the pharmacokinetics of vecurinium, particularly in distribution and elimination phases.
Xue
F
F
Plastic Surgery Hospital, CAMS, Beijing.
Liu
Q
Q
Zou
Q
Q
An
G
G
Luo
L
L
D000293:Adolescent; D000328:Adult; D006438:Hemodilution / Q000379:methods; D006801:Humans; D009455:Neurofibroma / Q000378:metabolism / Q000601:surgery; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D012888:Skull Neoplasms / Q000378:metabolism / Q000601:surgery; D013518:Surgery, Plastic; D014673:Vecuronium Bromide / Q000493:pharmacokinetics*
D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide