Synthesis and electrochemical studies of a new iron tetra-catecholamide complex.
A new tetra-catecholamide compound N5,N6-thiodipropanoyl-bis[N1,N10-bis(2,3-dihydroxybenzoyl-spermidi ne)] (H8L) has been synthesised as an iron chelator of Fe (III). Cyclic voltammogram of the iron complex H2LFe run under an argon atmosphere shows a quasi-reversible redox process with E0 = -430 mV vs. SCE in CH3OH/H20 (60/40). This value approaches the range of biological reductants and consequently the complex may mimic the release of iron from enterobactin to the agents which are directly involved in cell metabolism.
Cheraïti
N
N
Laboratoire de Chimie de Coordination Bioorganique et Bioinorganique, ICMO URA, Université de Paris-Sud, Orsay, France.
Brik
M E
ME
Bricard
L
L
Keita
B
B
Nadjo
L
L
Gaudemer
A
A
D002395:Catecholamines / Q000138:chemical synthesis* / Q000737:chemistry; D004563:Electrochemistry; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013058:Mass Spectrometry; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
D002395:Catecholamines; D007502:Iron Chelating Agents; C121653:N5,N6-thiodipropanoylbis(N1,N10-bis(2,3-dihydroxybenzoylspermidine)); D013095:Spermidine