Amplitude reduction of plasma melatonin rhythm in association with an internal desynchronization in a subject with non-24-hour sleep-wake syndrome.
The plasma melatonin rhythm was measured longitudinally in a subject with non-24-h sleep-wake syndrome, and the amplitude and area under the curve (AUC) of the melatonin rhythm were investigated in relation to the sleep-wake cycle. When the melatonin rhythm and sleep-wake rhythm were internally desynchronized, the amplitude and the AUC were reduced significantly. These parameters were not influenced by external melatonin administration. These results suggest that a causal relationship between the reduction of circadian oscillation and internal desynchronization exists in this subject.
Masubuchi
S
S
Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Hashimoto
S
S
Endo
T
T
Honma
S
S
Honma
K
K
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000097:blood*; D017286:Polysomnography; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D008550:Melatonin