title: Sporadic Creutzfeldt-Jakob disease presenting as major depression.
abstract: We describe a 68-year-old white woman who initially had symptoms of major depression and was admitted to a psychiatric hospital where she had electroconvulsive therapy. With failure of psychiatric treatment and subsequent rapidly progressive dementia, she had left frontal brain biopsy. The biopsy revealed spongiform changes, the hallmark of Creutzfeldt-Jakob disease (CJD). We report a case of sporadic CJD with unusual initial presentation of psychiatric symptoms.
authors.affiliation: Department of Medicine, Greater Baltimore Medical Center, MD, USA.
authors.forename: T T
authors.initials: TT
authors.lastname: Jiang
authors.forename: H
authors.initials: H
authors.lastname: Moses
authors.forename: H
authors.initials: H
authors.lastname: Gordon
authors.forename: E
authors.initials: E
authors.lastname: Obah
mesh_terms: D000368:Aged; D015415:Biomarkers; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D003866:Depressive Disorder / Q000175:diagnosis*; D003951:Diagnostic Errors; D004569:Electroencephalography; D005260:Female; D006801:Humans; D011328:Prions / Q000032:analysis
chemical_list: D015415:Biomarkers; D011328:Prions