title: Sympathetic overactivity from fenfluramine-phentermine overdose.
abstract: A 24-year-old male presented to the emergency department with hyperadrenergic manifestations of fenfluramine-phentermine overdose: tachycardia, mydriasis, fever, diaphoresis, hyperventilation, and combativeness. Sedatives, neuromuscular paralytics, adrenergic antagonists, and mechanical ventilation were required to care for the patient. In addition, the patient had self-inflicted 15% TBSA second-degree burns and developed adult respiratory distress syndrome which required continued intubation and mechanical ventilation for 12 days. The patient had split thickness skin grafts for his leg burns on day 11. He was discharged after a 26-day hospital stay. We are unaware of any previously reported cases of fenfluramine-phentermine overdose with such profound degree of sympathetic storm.
authors.affiliation: Department of Emergency Medicine, University of Kentucky Medical Center, Lexington 40536-0236, USA.
authors.forename: R
authors.initials: R
authors.lastname: Koury
authors.forename: C K
authors.initials: CK
authors.lastname: Stone
authors.forename: J S
authors.initials: JS
authors.lastname: Stapczynski
authors.forename: J
authors.initials: J
authors.lastname: Blake
mesh_terms: D018674:Adrenergic Antagonists / Q000627:therapeutic use; D000328:Adult; D001067:Appetite Depressants / Q000506:poisoning*; D002056:Burns / Q000150:complications*; D004338:Drug Combinations; D062787:Drug Overdose / Q000150:complications / Q000628:therapy; D005277:Fenfluramine / Q000506:poisoning*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000627:therapeutic use; D010645:Phentermine / Q000506:poisoning*; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy; D013406:Suicide, Attempted; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D018674:Adrenergic Antagonists; D001067:Appetite Depressants; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D009466:Neuromuscular Blocking Agents; D005277:Fenfluramine; D010645:Phentermine