Scavenger receptor BI and cholesterol trafficking.
Scavenger receptor BI (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
Williams
D L
DL
Department of Pharmacological Sciences, University Medical Centre, State University of New York at Stony Brook, 11794, USA. dave@pharm.sunysb.edu
Connelly
M A
MA
Temel
R E
RE
Swarnakar
S
S
Phillips
M C
MC
de la Llera-Moya
M
M
Rothblat
G H
GH
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology; D018955:CD36 Antigens; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism; D008565:Membrane Proteins; D011971:Receptors, Immunologic / Q000378:metabolism* / Q000502:physiology; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D001053:Apolipoproteins; D018955:CD36 Antigens; D002788:Cholesterol Esters; C059714:HDL cholesteryl ester; D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D002784:Cholesterol