Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain.
Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions.
Rugarn
O
O
Division of Obstetrics and Gynecology, Faculty of Health Sciences, Linköping University, Sweden. olof.rugarn@lio.se
Theodorsson
A
A
Hammar
M
M
Theodorsson
E
E
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D019004:Galanin / Q000378:metabolism*; D009640:Norethindrone / Q000494:pharmacology*; D010052:Ovariectomy; D010919:Placebos; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D051381:Rats
D010919:Placebos; D011374:Progesterone; D004958:Estradiol; D019004:Galanin; D009640:Norethindrone