The effects of vasoconstrictor on transmission of impulses in the peripheral nerve.
The effects of extraneural and intramuscular applications of l-adrenaline on peripheral nerve function were examined. Change in the compound action potential was monitored until a complete conduction block was obtained if it occurred within 100 min. Extraneural application of 0.5 ml l-adrenaline to an isolated segment of the sciatic nerve of the rat in three concentrations of 1:100,000; 1:10,000, and 1:2,000 resulted in complete conduction block within 8 min. However, intramuscular injections of similar concentrations resulted in concentration dependent neural blockades with the highest concentration causing conduction blockade in 27.1 +/- 8.0 min.
Falaiye
V O
VO
Department of Oral and Maxillofacial Surgery, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Rood
J P
JP
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular; D008297:Male; D009407:Nerve Block / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D004837:Epinephrine