title: A novel K+ channel blocking toxin from Tityus discrepans scorpion venom.
abstract: A novel toxin (TdK1) was purified from the venom of the scorpion Tityus discrepans, sequenced and functionally characterized. It contains 37 amino acid residues and blocks reversible the shakerB K+ channel expressed in SF9 cells with a Kd in the order of 280 nM. The proposed systematic nomenclature for this peptide is alpha-KTx4.3.
authors.affiliation: Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. gdsuze@ivic.ivic.ve
authors.forename: G
authors.initials: G
authors.lastname: D'Suze
authors.forename: F
authors.initials: F
authors.lastname: Zamudio
authors.forename: F
authors.initials: F
authors.lastname: Gómez-Lagunas
authors.forename: L D
authors.initials: LD
authors.lastname: Possani
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D008970:Molecular Weight; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012604:Scorpion Venoms / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid; D051637:Shaker Superfamily of Potassium Channels
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012604:Scorpion Venoms; D051637:Shaker Superfamily of Potassium Channels; C120911:alpha-KTx4.3 toxin