title: Older subjects show no age-related decrease in cardiac baroreceptor sensitivity.
abstract: OBJECTIVE
  To examine the relationship between age, blood pressure and cardiac baroreceptor sensitivity derived from spectral analysis, the Valsalva manoeuvre and impulse response function.
  
  
  METHODS
  We studied 70 healthy normotensive volunteers who were free from disease and not taking medication with cardiovascular or autonomic effects. We measured beat-to-beat arterial blood pressure and used standard surface electrocardiography to record pulse interval under standardized conditions with subjects resting supine as well as during three Valsalva manoeuvres. We performed single, multiple and stepwise regression of patient characteristics against cardiac baroreceptor sensitivity results.
  
  
  RESULTS
  There is a non-linear decline in cardiac baroreceptor sensitivity with advancing age, increasing systolic blood pressure and heart rate values (except for the Valsalva-derived result), but little further decline after the fourth decade. Only age significantly influenced values derived using the Valsalva manoeuvre and impulse response analysis. Using spectral analysis, age, systolic and diastolic blood pressure and heart rate influenced cardiac baroreceptor sensitivity, age contributing to 50% of the variability. Age also influenced the relationship between pulse interval and blood pressure, possibly indicating more non-baroreceptor-mediated changes with advancing age.
  
  
  CONCLUSIONS
  Although age is the dominant factor influencing cardiac baroreceptor sensitivity in this normotensive population, there is little change in mean values after 40 years of age. The differences in the relationship between pulse interval and blood pressure with advancing age have implications for the calculation of cardiac baroreceptor sensitivity using spectral analysis.
authors.affiliation: Department of Medicine for the Elderly, University of Leicester, The Glenfield Hospital, UK.
authors.forename: S L
authors.initials: SL
authors.lastname: Dawson
authors.forename: T G
authors.initials: TG
authors.lastname: Robinson
authors.forename: J H
authors.initials: JH
authors.lastname: Youde
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: M A
authors.initials: MA
authors.lastname: James
authors.forename: P J
authors.initials: PJ
authors.lastname: Weston
authors.forename: R B
authors.initials: RB
authors.lastname: Panerai
authors.forename: J F
authors.initials: JF
authors.lastname: Potter
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012737:Sex Factors; D014636:Valsalva Maneuver