title: Radiation therapy for a rising PSA level after radical prostatectomy.
abstract: With the advent of routine prostate-specific antigen (PSA) testing in asymptomatic young men, the number of patients undergoing radical prostatectomy is increasing. Effective therapy for the 30% to 40% of men who recur following radical prostatectomy is essential. Salvage radiation therapy for a rising serum PSA level is an effective therapy for controlling local recurrence. The impact of salvage radiotherapy on disease-free survival is promising, but the guidelines of therapy are not well established. The best candidates for salvage radiotherapy are those with a serum PSA level < 2 ng/mL with no palpable recurrence and complete urinary continence.
authors.affiliation: Department of Urology, Wayne State University School of Medicine, and the Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA.
authors.forename: R
authors.initials: R
authors.lastname: Tiguert
authors.forename: J D
authors.initials: JD
authors.lastname: Forman
authors.forename: M
authors.initials: M
authors.lastname: Hussain
authors.forename: D P
authors.initials: DP
authors.lastname: Wood
mesh_terms: D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis
chemical_list: D017430:Prostate-Specific Antigen