title: [Hyperkalemic periodic muscle paralysis in primary adrenocortical insufficiency. A case report].
abstract: 20-years old man was admitted to the hospital because of a few paroxysmal muscle paralysis episodes with pronounced periodic hiperkalemia (maximal 9.8 mmol/l). The first episode was preceded by a very hard physical effort. Primary adrenal insufficiency was recognised on the basis of clinical, humoral and biochemical examinations. There was elevated ACTH and a very low serum level of cortisol and aldosterone. There was slight metabolic acidosis and hiponatremia. The patient was treated with hydrocortisone and fludrocortisone acetate (Cortineff) with positive result. During one year of this therapy his general condition was very good and clinical, humoral and biochemical signs (except of metabolic acidosis) resolved. Neurological symptoms and a very high serum kalium level were the most important signs of primary adrenal insufficiency in the presented case.
authors.affiliation: Katedry i Kliniki Chorób Wewnetrznych i Nefrologii Akademii Medycznej w Warszawie.
authors.forename: J
authors.initials: J
authors.lastname: Przedlacki
authors.forename: M
authors.initials: M
authors.lastname: Debowska
authors.forename: J
authors.initials: J
authors.lastname: Matuszkiewicz-Rowińska
authors.forename: P
authors.initials: P
authors.lastname: Janik
mesh_terms: D000138:Acidosis / Q000209:etiology; D000309:Adrenal Insufficiency / Q000097:blood* / Q000150:complications* / Q000188:drug therapy; D000324:Adrenocorticotropic Hormone / Q000097:blood* / Q000652:urine; D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000652:urine; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000627:therapeutic use / Q000652:urine; D006947:Hyperkalemia / Q000150:complications*; D007010:Hyponatremia / Q000209:etiology; D008297:Male; D018482:Muscle, Skeletal; D010243:Paralysis / Q000209:etiology*; D010507:Periodicity
chemical_list: D000893:Anti-Inflammatory Agents; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D005438:Fludrocortisone; D006854:Hydrocortisone