2-5A-PNA complexes: a novel class of antisense compounds.
This paper presents the fully automated solid phase synthesis of 2-5A-PNA hybrids. These stable antisense probes cause RNase L mediated hydrolysis of target RNA sequences.
Verheijen
J C
JC
Leiden Institute of Chemistry, The Netherlands.
Bayly
S F
SF
Player
M R
MR
Torrence
P F
PF
van der Marel
G A
GA
van Boom
J H
JH
D001483:Base Sequence; D004722:Endoribonucleases / Q000737:chemistry; D006868:Hydrolysis; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*
D016376:Oligonucleotides, Antisense; D020135:Peptide Nucleic Acids; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease