PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
Wrobel
J
J
Wyeth-Ayerst Research, Inc., CN 8000, Princeton, New Jersey 08543-8000, USA.
Sredy
J
J
Moxham
C
C
Dietrich
A
A
Li
Z
Z
Sawicki
D R
DR
Seestaller
L
L
Wu
L
L
Katz
A
A
Sullivan
D
D
Tio
C
C
Zhang
Z Y
ZY
D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D051379:Mice; D008820:Mice, Obese; D008958:Models, Molecular; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D005663:Furans; D007004:Hypoglycemic Agents; D011994:Recombinant Proteins; D013876:Thiophenes; D017027:Protein Tyrosine Phosphatases