Synthesis of three diosgenyl saponins: dioscin, polyphyllin D, and balanitin 7.
Dioscin, polyphyllin D, and balanitin 7, which belong to a group of structurally similar diosgenyl saponins with promising bioactivities, were synthesized by stepwise glycosylation.
Deng
S
S
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, PR China.
Yu
B
B
Hui
Y
Y
Yu
H
H
Han
X
X
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006031:Glycosylation; D007202:Indicators and Reagents; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009904:Optical Rotation; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
D007202:Indicators and Reagents; D012503:Saponins; C121204:balanitin 7; C121203:polyphyllin D; C019357:dioscin; D004144:Diosgenin