title: Developmental evolution: Axial patterning in insects.
abstract: The Drosophila bicoid gene is well known for encoding a protein that forms a morphogenetic gradient with a key role in anterior patterning of the fruitfly embryo. Recent results suggest the evolution of bicoid might have involved dramatic changes in function - essentially the invention of a new regulatory protein.
authors.affiliation: University Museum of Zoology, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, UK.
authors.forename: P
authors.initials: P
authors.lastname: Dearden
authors.forename: M
authors.initials: M
authors.lastname: Akam
mesh_terms: D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000502:physiology*; D004330:Drosophila / Q000196:embryology; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000737:chemistry; D018398:Homeodomain Proteins / Q000378:metabolism / Q000502:physiology; D019476:Insect Proteins / Q000502:physiology; D007313:Insecta / Q000196:embryology*; D012097:Repressor Proteins / Q000378:metabolism; D015534:Trans-Activators / Q000502:physiology; D014231:Tribolium / Q000196:embryology
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; C085607:Zen protein, Drosophila; C056478:bcd protein, Drosophila