Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.
Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.
Ryder
T R
TR
Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA.
Hu
L Y
LY
Rafferty
M F
MF
Lotarski
S M
SM
Rock
D M
DM
Stoehr
S J
SJ
Taylor
C P
CP
Weber
M L
ML
Miljanich
G P
GP
Millerman
E
E
Szoke
B G
BG
D000161:Acoustic Stimulation; D000595:Amino Acid Sequence; D000814:Aniline Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D002121:Calcium Channel Blockers; C121658:PD 181283; D007930:Leucine