Macrolide Analogues of the Novel Immunosuppressant Sanglifehrin: New Application of the Ring-Closing Metathesis Reaction.
Macrocycles containing a conjugated 1,3-diene moiety have been synthesized for the first time in good yields by the ring-closing metathesis reaction [Eq. (1)]. The new compounds represent cyclophilin-binding, simplified analogues of the macrocyclic core of sanglifehrin A, an immunosuppressant which binds with high affinity to cyclophilin.
Martin Cabrejas LM
Novartis Pharma AG, S-350.2.07, CH-4002 Basel (Switzerland).
Rohrbach
S
Wagner
D
Kallen
J
Zenke
G
Wagner
J