Activities of new antimicrobial agents (trovafloxacin, moxifloxacin, sanfetrinem, and quinupristin-dalfopristin) against Bacteroides fragilis group: comparison with the activities of 14 other agents.
The antimicrobial activities of trovafloxacin, moxifloxacin, sanfetrinem, quinupristin-dalfopristin, and 14 other antimicrobial agents against 218 Bacteroides fragilis group strains were determined. A group of 10 imipenem-resistant strains were also tested. Imipenem, meropenem, and sanfetrinem had the lowest MICs of all of the beta-lactams. Quinupristin-dalfopristin inhibited all of the strains at 2 microg/ml. Overall, the MICs of trovafloxacin and moxifloxacin for 90% of the strains tested were 1 and 2 microg/ml, respectively.
Betriu
C
C
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, 28040 Madrid, Spain. cbetriu@efd.net
Gómez
M
M
Palau
M L
ML
Sánchez
A
A
Picazo
J J
JJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D001441:Bacteroides fragilis / Q000187:drug effects*; D024841:Fluoroquinolones; D007769:Lactams; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology*; D011804:Quinolines; D014769:Virginiamycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D007769:Lactams; D009287:Naphthyridines; D011804:Quinolines; C104757:sanfetrinem; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; C080163:trovafloxacin; D000077266:Moxifloxacin