Acute hypermagnesemia and respiratory arrest following infusion of MgSO4 for tocolysis.
Hypermagnesemia (6.95 mmol/l) and respiratory arrest occurred to a 20-year-old female (G3P2002) at 26 weeks of gestation during tocolytic treatment with MgSO4.7H2O (density greater than plasmalyte) injected into an i.v. infusion bag containing 1 l of plasmalyte without mixing. The patient was rescued with calcium gluconate and normal pregnancy continued. It is important to adequately mix an i.v. solution after adding a drug particularly when the drug-containing solution has greater density than the parent i.v. solution.
Cao
Z
Z
Department of Pathology and Laboratory Medicine, University of Louisville Hospital, KY 40292, USA.
Bideau
R
R
Valdes
R
R
Elin
R J
RJ
D000328:Adult; D002125:Calcium Gluconate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000097:blood* / Q000506:poisoning; D011041:Poisoning / Q000188:drug therapy; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000188:drug therapy; D015149:Tocolytic Agents / Q000009:adverse effects*
D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D002125:Calcium Gluconate