title: Body fat distribution with long-term dietary restriction in adult male rhesus macaques.
abstract: Dietary restriction (DR) is the only intervention that has been shown to increase average and median life span in laboratory rodents. The effect of long-term, moderate DR on body composition and fat distribution was evaluated in male rhesus monkeys. Thirty animals (8-14 years of age)fed either 30% less than baseline intake (R, n = 15) or allowed to eat to satiety (C, n = 15), have been assessed semiannually using somatometrics and dual-energy alpha-ray absorptiometry (DXA)for 7.5 years. R subjects have reduced body weight (p <.0001), total body fat (p < .0001), and percentage body fat located in the abdominal region (p < .05). In addition, there has been a sustained reduction in plasma leptin concentrations (p <.001). These findings suggest reduced risk for common morbidities, such as insulin resistance, dyslipidemia, and type 2 diabetes mellitus, that are associated with advancing age and increased levels of bodyfat, especially in the visceral depot.
authors.affiliation: Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Colman
authors.forename: J J
authors.initials: JJ
authors.lastname: Ramsey
authors.forename: E B
authors.initials: EB
authors.lastname: Roecker
authors.forename: T
authors.initials: T
authors.lastname: Havighurst
authors.forename: J C
authors.initials: JC
authors.lastname: Hudson
authors.forename: J W
authors.initials: JW
authors.lastname: Kemnitz
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000818:Animals; D001823:Body Composition; D001835:Body Weight; D004032:Diet; D020738:Leptin; D008253:Macaca mulatta; D008297:Male; D009765:Obesity / Q000150:complications; D011506:Proteins / Q000032:analysis
chemical_list: D020738:Leptin; D011506:Proteins