title: Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.
abstract: Candida albicans, the most prevalent fungal pathogen in humans, is thought to lack a sexual cycle. A set of C. albicans genes has been identified that corresponds to the master sexual cycle regulators a1, alpha1, and alpha2 of the Saccharomyces cerevisiae mating-type (MAT) locus. The C. albicans genes are arranged in a way that suggests that these genes are part of a mating type-like locus that is similar to the mating-type loci of other fungi. In addition to the transcriptional regulators a1, alpha1, and alpha2, the C. albicans mating type-like locus contains several genes not seen in other fungal MAT loci, including those encoding proteins similar to poly(A) polymerases, oxysterol binding proteins, and phosphatidylinositol kinases.
authors.affiliation: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Hull
authors.forename: A D
authors.initials: AD
authors.lastname: Johnson
mesh_terms: D019870:1-Phosphatidylinositol 4-Kinase / Q000235:genetics; D000595:Amino Acid Sequence; D002176:Candida albicans / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D007438:Introns; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D009875:Operator Regions, Genetic; D011062:Polynucleotide Adenylyltransferase / Q000235:genetics; D011987:Receptors, Steroid / Q000235:genetics; D011995:Recombination, Genetic; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins; D014158:Transcription, Genetic; D014170:Transformation, Genetic; D000098825:Oxysterol Binding Proteins
chemical_list: D018398:Homeodomain Proteins; C096063:MATA1 protein, S cerevisiae; C062928:MATA2 protein, S cerevisiae; D011987:Receptors, Steroid; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D000098825:Oxysterol Binding Proteins; D019870:1-Phosphatidylinositol 4-Kinase; C441760:PIK1 protein, S cerevisiae; D011062:Polynucleotide Adenylyltransferase