title: [Possibility of false negative results in the diagnosis of lung neoplasms with computerized tomography].
abstract: OBJECTIVE
  To describe the radiological appearance of overlooked malignant pulmonary lesions at CT and to analyze the reasons of misdiagnosis.
  
  
  METHODS
  Ten patients with pulmonary malignant lesions (PML) overlooked at first CT examination were selected among patients with lung cancer who were referred to our institution between 1994 and 1997. CT scans were evaluated by consensus of two chest radiologists with different experience in chest radiology, who were blinded to the final diagnosis.
  
  
  RESULTS
  The overlooked pulmonary lesions were 5 endobronchial cancers and 5 central solitary nodules. The mean diameter of the lesions ranged 1 to 2 cm. Furthermore, 7 patients had associated pleural and/or parenchymal abnormalities. The technical quality of CT examinations was considered good in 2 cases, acceptable in 6 cases, poor in 2 cases. PML were correctly identified in 6/10 cases by the first (more experienced) radiologist and in 4/10 by the second radiologist. Four cases were considered suspect for the presence of PML by the first radiologist, 2 by the second.
  
  
  CONCLUSIONS
  Endobronchial location of the tumors and their small size were the most frequent causes of misdiagnosis of PML at chest CT in our series. However, a systematic evaluation of CT scans can reduce the percentage of missed lesions.
authors.affiliation: Istituto di Scienze Radiologiche dell'Università G. D'Annunzio, Chieti.
authors.forename: J
authors.initials: J
authors.lastname: Mancini
authors.forename: B
authors.initials: B
authors.lastname: Feragalli
authors.forename: C
authors.initials: C
authors.lastname: Ciccotosto
authors.forename: M L
authors.initials: ML
authors.lastname: Storto
authors.forename: A
authors.initials: A
authors.lastname: Guidotti
mesh_terms: D000368:Aged; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed