title: Imaging functional activation of the auditory cortex during focal repetitive transcranial magnetic stimulation of the primary motor cortex in normal subjects.
abstract: Positron emission tomography (PET) during focal repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising approach to study cortical connectivity in awake humans. However, the noise caused by the discharging magnetic coil might have confounding effects on the rTMS-related cortical activation pattern. In twelve healthy volunteers, 18-fluoro-2-deoxy-D-glucose (18FDG) PET was employed to visualize the functional activation of the primary auditory cortex (PAC) during 2 Hz rTMS of the left primary sensorimotor hand area. Magnetic stimuli (1800) were applied at an intensity of 140% of motor resting threshold during the uptake period of 18FDG. Though all subjects wore earplugs, rTMS-related noise induced a consistent bilateral increase of regional glucose utilization in the PAC (P < 0.05, corrected). Thus, rTMS-related acoustic input needs to be taken into account in combined rTMS/PET studies.
authors.affiliation: Department of Neurology, Technische Universität München, Munich, Germany. hartwig.siebner@neuro.med.tu-muenchen.de
authors.forename: H R
authors.initials: HR
authors.lastname: Siebner
authors.forename: M
authors.initials: M
authors.lastname: Peller
authors.forename: F
authors.initials: F
authors.lastname: Willoch
authors.forename: C
authors.initials: C
authors.lastname: Auer
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
authors.forename: A
authors.initials: A
authors.lastname: Drzezga
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
authors.forename: B
authors.initials: B
authors.lastname: Conrad
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D007839:Functional Laterality; D005947:Glucose / Q000378:metabolism; D006225:Hand / Q000294:innervation; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012016:Reference Values; D012984:Software; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods; D050781:Transcranial Magnetic Stimulation
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose