title: Differential uptake of TI-201 by small-cell lung cancer in a patient with pneumoconiosis-related pulmonary nodules.
abstract: A 68-year-old man with pneumoconiosis was thought to have small-cell lung cancer based on the results of a biopsy of a bone tumor. Three pulmonary nodules were observed on a chest radiograph. Compared with a chest radiograph taken 4 months earlier, one of the nodules had grown. It was difficult to differentiate this nodule from pneumoconiosis-related benign pulmonary nodules from the appearance on the chest radiograph and CT. Ga-67 scintigraphy and TI-201 lung SPECT were performed to characterize these nodules. TI-201 SPECT showed differential high uptake in the enlarged nodule, whereas Ga-67 scintigraphy showed equally intense uptake in all these nodules. Transbronchial biopsy of the nodule that showed high TI-201 uptake revealed cancer cell nests against a background of interstitial fibrosis. The pathologic diagnosis was small-cell lung cancer that had developed in lung scar tissue. This case suggests the utility of TI-201 in scintigraphic assessments of pneumoconiosis-related pulmonary nodules when lung cancer is suspected.
authors.affiliation: Department of Radiology, Asahikawa Medical College, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shuke
authors.forename: N
authors.initials: N
authors.lastname: Tonami
authors.forename: H
authors.initials: H
authors.lastname: Shintani
authors.forename: T
authors.initials: T
authors.lastname: Kameyama
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Kinuya
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Michigishi
authors.forename: T
authors.initials: T
authors.lastname: Aburano
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D005710:Gallium Radioisotopes; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008297:Male; D011009:Pneumoconiosis / Q000150:complications / Q000000981:diagnostic imaging*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes; D013794:Thallium Radioisotopes