Gene silencing: Maintaining methylation patterns.
Recent studies of an Arabidopsis gene family have shown that inverted repeats can be potent silencers of other identical sequences in the genome, causing them to become stably methylated at cytosine residues. From mutations affecting this process we are beginning to understand how methylation patterns are maintained.
Jacobsen
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Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, California 90095-1606, USA.
D019747:Aldose-Ketose Isomerases / Q000235:genetics; D000483:Alleles; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics*; D029681:Arabidopsis Proteins; D003596:Cytosine / Q000378:metabolism; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics; D017353:Gene Deletion; D018506:Gene Expression Regulation, Plant / Q000235:genetics*; D020868:Gene Silencing; D009154:Mutation; D014157:Transcription Factors / Q000235:genetics
D029681:Arabidopsis Proteins; C118957:DDM1 protein, Arabidopsis; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D003596:Cytosine; D019747:Aldose-Ketose Isomerases; C029865:phosphoribosylanthranilate isomerase