title: Hemostasis of punctured vessels using Doppler-guided high-intensity ultrasound.
abstract: The use of Doppler ultrasound was investigated to determine if it would aid in guiding the application of high-intensity focused ultrasound (HIFU) to stop bleeding from punctured vessels. Major vessels (abdominal aorta, illiac, carotid, common femoral and superficial femoral arteries and the jugular vein) were surgically exposed, punctured and treated in anesthetized pigs. Treatment was applied when the Doppler sounds indicated the focus coincided with the bleeding site. In 89 treatment trials, the average time to achieve major hemostasis (a point where bleeding was reduced to a level of only oozing) was 8 s, and for complete hemostasis was 13 s. These times were significantly shorter than those of an identical former study in which only visual guidance was used. In that study, the average times for major and complete hemostasis were 40 and 62 s, respectively. The advantage of Doppler guidance in applying HIFU in treating bleeding vessels was demonstrated.
authors.affiliation: Department of Bioengineering, University of Washington, Seattle 98195, USA. rmartin@u.washington.edu
authors.forename: R W
authors.initials: RW
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Vaezy
authors.forename: P
authors.initials: P
authors.lastname: Kaczkowski
authors.forename: G
authors.initials: G
authors.lastname: Keilman
authors.forename: S
authors.initials: S
authors.lastname: Carter
authors.forename: M
authors.initials: M
authors.lastname: Caps
authors.forename: K
authors.initials: K
authors.lastname: Beach
authors.forename: M
authors.initials: M
authors.lastname: Plett
authors.forename: L
authors.initials: L
authors.lastname: Crum
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000000981:diagnostic imaging / Q000293:injuries*; D006488:Hemostasis, Surgical / Q000379:methods; D006489:Hemostatic Techniques; D011677:Punctures; D013552:Swine; D013997:Time Factors; D014464:Ultrasonic Therapy / Q000379:methods; D018608:Ultrasonography, Doppler