title: Transmission of factor VII deficiency through liver transplantation.
abstract: The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.
authors.affiliation: The Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, Box 1104, One Gustave L. Levy Place, New York, New York 10029-6574, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Guy
authors.forename: J F
authors.initials: JF
authors.lastname: Magliocca
authors.forename: S
authors.initials: S
authors.lastname: Fruchtman
authors.forename: P
authors.initials: P
authors.lastname: McDonough
authors.forename: S
authors.initials: S
authors.lastname: Emre
authors.forename: L
authors.initials: L
authors.lastname: Kim-Schluger
authors.forename: P A
authors.initials: PA
authors.lastname: Sheiner
authors.forename: T M
authors.initials: TM
authors.lastname: Fishbein
authors.forename: M E
authors.initials: ME
authors.lastname: Schwartz
authors.forename: C M
authors.initials: CM
authors.lastname: Miller
mesh_terms: D000328:Adult; D005168:Factor VII Deficiency / Q000175:diagnosis; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011517:Prothrombin Time; D014019:Tissue Donors