Lymphocyte glutathione levels in acute leukemia.
The current interest in the clinical significance of the glutathione estimation in leukemia is due to its widespread effect on the cell constituent and cell function of the hematopoietic system. It helps and protects the cells against free radicals and reactive oxygen products. The present study was conducted to estimate glutathione levels in lymphocytes of 20 patients with acute leukemia before and after chemotherapy to observe the relation of glutathione level to response to chemotherapy. Twenty age and sex matched healthy volunteers served as control. In acute myeloid leukemia, the levels were almost double than that of controls (P<0.001). In acute lymphoid leukemia they were 2.5 times of the control. Lymphocyte glutathione levels was higher in active phase of disease than in remission. Lymphocyte glutathione level could act as a marker of leukemic activity and may help to predict onset of relapse. But, it is not only the determinant of response to chemotherapy.
Singh Ghalaut
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Department of Biochemistry, Postgraduate Institute of Medical Sciences, Rohtak, India.
Kharb
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Ghalaut
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PS
Rawal
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D000293:Adolescent; D000328:Adult; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy
D005978:Glutathione