[The immunological aspects of a hip joint lesion in childhood].
The paper presents an in-depth analysis of immunological mechanisms of the hip joint synovitis development in children. Studied in the pediatric patients with transient coxitis, Perthes disease, and tuberculous coxitis (n = 54, 15, and 15 respectively) with the aid of flow cytofluorometer FACStar PLUS was the subpopulation of immunocompetent cells with a wide spectrum of MCAB. Controls (n = 35) were sex and age-matched. Comparative analysis of immunological parameters in the above children disclosed a toxic-and-allergic origination of transient synovitis with predominant affection of the T-cell link of immunity (T-helpers failure and activation of T-suppressors). Joint mucose injury was noted to be developing against the background of reduction of serum IgA. Activation of non-specific mechanisms (natural killers, increase in SDH activity) is of compensatory character. Mechanisms of activation of cell processes (expression of panmitogenic receptor CD4+ antigen) in Perthes disease warrant further studies. In patients with tuberculous coxitis, immunological incompetence develops in the presence of cytotoxic reactions and activation of the B-link, with the production of IgM being on the increase but with no essential changes in the IgG fraction. It is necessary that selective stimulators of T-helpers be included into the treatment scheme together with drugs capable of exerting a selective effect on the T-link of immunity.
Bebeshko
A V
AV
Bazyka
D A
DA
D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D005260:Female; D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods; D006621:Hip Joint / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007834:Lasers; D007873:Legg-Calve-Perthes Disease / Q000276:immunology; D008297:Male; D013585:Synovitis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014394:Tuberculosis, Osteoarticular / Q000276:immunology
D000949:Histocompatibility Antigens Class II