title: Quality of life in end-stage renal disease patients after successful kidney transplantation: development of the ESRD symptom checklist - transplantation module.
abstract: The End-Stage Renal Disease Symptom Checklist - Transplantation Module (ESRD-SCL((R))) was developed to assess the specific physical and psychological quality of life of renal transplant recipients, with a special focus on side effects of immune system suppression therapy. A list of potentially relevant items was administered to 458 transplant recipients. The symptoms present in >20% of patients were chosen, and factor analysis was used to create the final questionnaire which consists of 43 items in six dimensions: (1) limited physical capacity (10 items; internal consistency: Cronbach's alpha = 0.85); (2) limited cognitive capacity (8 items, alpha = 0.82); (3) cardiac and renal dysfunction (7 items, alpha = 0. 76); (4) side effects of corticosteroids (5 items, alpha = 0.77); (5) increased growth of gum and hair (5 items, alpha = 0.78), and (6) transplantation-associated psychological distress (8 items, alpha = 0.80). All questions are scored on a five-point Likert scale. Validity was demonstrated in correlation with corresponding SF-36 scales and in a stepwise hierarchical regression model predicting the subscales of the ESRD-SCL by sociodemographic and medical data. The ESRD-SCL was found to have adequate reliability, test-retest correlations in a subsample of 88 stable patients after 1 year, and construct validity.
authors.affiliation: Institute for Medical Psychology, Center for Internal Medicine, University Clinics, University of Essen, Germany. franke@uni-essen.de
authors.forename: G H
authors.initials: GH
authors.lastname: Franke
authors.forename: J
authors.initials: J
authors.lastname: Reimer
authors.forename: M
authors.initials: M
authors.lastname: Kohnle
authors.forename: P
authors.initials: P
authors.lastname: Luetkes
authors.forename: N
authors.initials: N
authors.lastname: Maehner
authors.forename: U
authors.initials: U
authors.lastname: Heemann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003710:Demography; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D015203:Reproducibility of Results; D012959:Socioeconomic Factors; D013223:Statistics as Topic