title: 8-aminoquinolines as anticoccidials - Part III.
abstract: Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
authors.affiliation: Animal Health Discovery, Pfizer Central Research, Kent.
authors.forename: R E
authors.initials: RE
authors.lastname: Armer
authors.forename: J S
authors.initials: JS
authors.lastname: Barlow
authors.forename: N
authors.initials: N
authors.lastname: Chopra
authors.forename: C J
authors.initials: CJ
authors.lastname: Dutton
authors.forename: D H
authors.initials: DH
authors.lastname: Greenway
authors.forename: S D
authors.initials: SD
authors.lastname: Greenwood
authors.forename: N
authors.initials: N
authors.lastname: Lad
authors.forename: J
authors.initials: J
authors.lastname: Shaw
authors.forename: A P
authors.initials: AP
authors.lastname: Thompson
authors.forename: K W
authors.initials: KW
authors.lastname: Thong
authors.forename: I
authors.initials: I
authors.lastname: Tommasini
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D003049:Coccidiostats / Q000737:chemistry / Q000494:pharmacology*; D004539:Eimeria / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000634:Aminoquinolines; D003049:Coccidiostats