title: [The C(27)-steroid hormones ecdysterone and calcitriol activate the phosphoinositol cycle in its membrane phase].
abstract: We have examined in vivo the capacities of two C27-steroid hormones-phytoecdysteroid ecdysterone (20-hydroxyecdysone, 10(-8) M) and calcitriol (1 alpha, 25-dihydroxyvitamin D3, 10(-12) M), as a modulators of phosphoinositide cycle in the brain and heart cells. Severe lines of evidence indicate that both hormones may acts as positive regulators of phosphoinositide hydrolysis by phospholipases C and D in membrane (0.5-30 min) pre-genomic phase of its actions. Thus, our findings identify ecdysterone, like calcitriol, as a positive regulator of [Ca2+]i, and protein kinase in the mammalian cells.
authors.affiliation: A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
authors.forename: A V
authors.initials: AV
authors.lastname: Kotsiuruba
authors.forename: O M
authors.initials: OM
authors.lastname: Bukhanevich
authors.forename: O F
authors.initials: OF
authors.lastname: Mehed'
authors.forename: S S
authors.initials: SS
authors.lastname: Tarakanov
authors.forename: A H
authors.initials: AH
authors.lastname: Berdishev
authors.forename: A V
authors.initials: AV
authors.lastname: Tuhanova
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000502:physiology*; D004441:Ecdysterone / Q000502:physiology*; D006868:Hydrolysis; D008566:Membranes / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010739:Phospholipase D / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000502:physiology*; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols; D004441:Ecdysterone; D010738:Type C Phospholipases; D010739:Phospholipase D; D002117:Calcitriol