Likelihood-based diagnostics for influential individuals in non-linear mixed effects model selection.
OBJECTIVE
Data from single individuals, or a small group of subjects may influence non-linear mixed effects model selection. Diagnostics routinely applied in model building may identify such individuals, but these methods are not specifically designed for that purpose and are, therefore, not optimal. We describe two likelihood-based diagnostics for identifying individuals that can influence the choice between two competing models.


METHODS
One method is based on a jackknife of the raw data on the individual level and refitting the model to each new data set. The second method is a calculation which utilises the contribution each individual make to the objective function values under each of the two models. The two methods were applied to model selection during analysis of a real data set.


RESULTS
The agreement between the methods was high. Individuals for whom there was a discrepancy between the methods tended to be those for which neither of the contending models described the data appropriately. Both methods identified individuals that influenced the model selection.


CONCLUSIONS
Two objective, specific and quantitative methods for identifying influential individuals in nonlinear mixed effects model selection have been presented. One of the methods doesn't require additional model fitting and is therefore particularly attractive.
Sadray
S
S
Department of Pharmacy, Faculty of Pharmacy, Uppsala University, Sweden.
Jonsson
E N
EN
Karlsson
M O
MO
D000367:Age Factors; D003627:Data Interpretation, Statistical; D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D010599:Pharmacokinetics