title: Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections.
abstract: Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of both virus-specific and non-virus-specific T cell populations mold T cell responses to viral infections.
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. raymond.welsh@ummed.edu
authors.forename: R M
authors.initials: RM
authors.lastname: Welsh
authors.forename: J M
authors.initials: JM
authors.lastname: McNally
mesh_terms: D000818:Animals; D017209:Apoptosis; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*