Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
Synthesis of a number of photoactive thiopurine-containing nucleosides was described. S-methylation of the synthesized compounds in the course of the reaction catalyzed by recombinant human thiopurine S-methyltransferase was studied by UV-spectroscopy.
Korshunova
G A
GA
Belozersky Institute, Moscow, Russia.
Krynetski
E Y
EY
Mtchedlidze
M T
MT
Agapkin
D V
DV
Evans
W E
WE
Krynetskaia
N F
NF
D006801:Humans; D008780:Methyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011994:Recombinant Proteins / Q000737:chemistry
D011684:Purine Nucleosides; D011994:Recombinant Proteins; D008780:Methyltransferases; C022745:thiopurine methyltransferase