[The frequencies of the vitamin D receptor gene alleles in adults of Han nationality in Beijing area].
Vitamin D receptor (VDR) gene is considered as one of candidate genes related to the genetic basis of bone and mineral metabolism. In order to determine VDR genotypes, we analysed the polymorphisms, or genotypes of Bsm I, Apa I, and Taq I restriction enzymes, by PCR technique in 223 unrelated healthy adults of Han nationality in Beijing area. Some of the VDR genotypes were also confirmed by Southern blotting analysis. We discovered that Chinese had high frequencies of b, a, T alleles, as high as 95%, 75%, and 95% respectively, which were different from those in Caucasians and Japanese, but similar to those in Koreans (P > 0.05). This difference gave us further insight into the different pathogeny of osteoporosis in various ethnics.
Zhao
J
J
PUMC Hospital, Beijing.
Zhou
X
X
Liu
G
G
Meng
X
X
Xing
X
X
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D002681:China; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People
D018167:Receptors, Calcitriol