title: Clinical evaluation of repeat apheresis donors in Japan.
abstract: OBJECTIVE
  To ascertain the safety of repeat apheresis donation, hematological and biochemical tests were performed on 511 donors with a donation rate of over 6 times per year for a period of 12-19 months.
  
  
  METHODS
  Repeat donors who had apheresis more than 6 times in the previous year were chosen. Data for the repeat donors at the start of the experiments were compared with those at the end of the study. Blood samples were taken prior to donation. Serum protein, albumin, immunoglobulin G, A, and M, serum ferritin levels were determined by biochemical tests.
  
  
  RESULTS
  When compared to prospective donors of 400 ml, WBC, lymphocytes, and serum ferritin levels were lower in a roughly frequency-dependent manner in female and male donor groups at the beginning of the study. All the data for the male group remained almost constant with increasing frequency of apheresis donation. However, in the female group, ferritin levels significantly decreased with over 21 donations.
  
  
  CONCLUSIONS
  The present data showed that the serum ferritin level of the female donors decreased the most with increasing frequency of apheresis donation. The cumulative RBC left in the collecting chamber and for the laboratory test is discussed in relation to a possible cause of iron deficiency in frequent apheresis donors.
authors.affiliation: Japanese Red Cross Aichi Blood Center, Aichi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Furuta
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Mizuno
authors.forename: T
authors.initials: T
authors.lastname: Kamiya
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
authors.forename: T
authors.initials: T
authors.lastname: Nakase
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
authors.forename: M
authors.initials: M
authors.lastname: Takenaka
authors.forename: T
authors.initials: T
authors.lastname: Ohkawa
authors.forename: S
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Kiyokawa
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: N
authors.initials: N
authors.lastname: Sekine
authors.forename: I
authors.initials: I
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D001781:Blood Component Removal; D001782:Blood Donors; D001798:Blood Proteins / Q000032:analysis; D004906:Erythrocyte Count; D005069:Evaluation Studies as Topic; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007564:Japan; D007958:Leukocyte Count; D008297:Male; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D007136:Immunoglobulins; D012709:Serum Albumin; D005293:Ferritins