Evaluation of oxidative stress parameters in blood of patients with laryngeal carcinoma.
OBJECTIVE
In this study, plasma lipid peroxidation as assessed by thiobarbituric acid reactive substances and erythrocyte antioxidant status markers namely CuZn superoxide dismutase, glutathione peroxidase, glutathione and plasma levels of vitamin C and E were investigated in 20 patients with larygneal carcinoma and 15 healthy controls.


METHODS
Lipid peroxidation was observed to be significantly higher (0.01 > p > 0.001) in the larynx carcinoma group in comparison to the healthy controls. Both stage I + 11 and stage III carcinoma patients were observed to have significantly higher thiobarbituric acid reactive substances than the control group. A significant difference was found in plasma vitamin E level between the control group and stage I + 11 and stage III carcinoma patients (p < 0.01, 0.05 > p > 0.02, respectively).


RESULTS
Our findings reveal the presence of increased lipooxidative damage in laryngeal carcinoma patients, but no change with respect to the endogenous antioxidant components-GSH, GSH Px, and CuZn SOD.
Seven
A
A
Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Turkey.
Civelek
S
S
Inci
E
E
Inci
F
F
Korkut
N
N
Burçak
G
G
D000328:Adult; D000975:Antioxidants / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000473:pathology; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018384:Oxidative Stress / Q000502:physiology*; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D014810:Vitamin E