HLA-DPB1 alleles in house dust mite allergic patients.
Associations were sought between the presence of allergic sensitivity to Der p 1, a major allergen from the house dust mite, and the HLA-DPB1 genotype. Whilst allergic patients did not differ from controls in DPB1 allelic distribution, there was a correlation of DPB1*11011 with strongly reactive T-cell proliferative responses to Der p 1 and high titre specific IgE to Dermatophagoides pteronyssinus.
O'Brien
R M
RM
University of Melbourne Department of Medicine at Western Hospital Footscray, Victoria, Australia.
Tait
B D
BD
Varney
M D
MD
Thomas
W R
WR
D000483:Alleles; D000485:Allergens / Q000235:genetics / Q000276:immunology; D000818:Animals; D039741:Antigens, Dermatophagoides; D004391:Dust / Q000009:adverse effects*; D005838:Genotype; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006682:HLA-DP Antigens / Q000235:genetics* / Q000276:immunology; D059868:HLA-DP beta-Chains; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D016130:Immunophenotyping; D008925:Mites / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins; D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains