Nefazodone-induced clitoral priapism.
A case is presented of painful priapism of the clitoris lasting 3 days, with a strong temporal association with the administration of nefazodone hydrochloride. Priapism has been described as a rare side-effect of drugs with high alpha1-adrenergic blocking potential. However, the alpha1-adrenergic blocking potential of nefazodone is moderate. Drug-induced clitoral priapism has been described for citalopram, bromocriptine, fluoxetine and trazodone combined with fluoxetine. To our knowledge, this is the first report in the literature about priapism of the clitoris associated with nefazodone.
Brodie-Meijer
C C
CC
Netherlands Pharmacovigilance Foundation Lareb, Hertogenbosch. amsterdam@lareb.nl
Diemont
W L
WL
Buijs
P J
PJ
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D002987:Clitoris / Q000187:drug effects*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010879:Piperazines; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014623:Vaginal Diseases / Q000139:chemically induced* / Q000473:pathology
D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone