Tissue deposits of hydroxyethyl starch (HES): dose-dependent and time-related.
Tissue deposits occur after administration of plasma substitutes. After hydroxyethyl starch (HES), deposits may last for months, causing pruritus and impairment of function. Because elimination of HES deposits has not been demonstrated in humans, we studied 26 patients, for up to 7 yr after HES administration, to assess HES storage. HES dose ranged from 0.34 to 15.00 g kg-1 body weight, and administration intervals from 1 day to 7 yr. Biopsies of the liver, muscle, spleen, intestine or skin were studied using light and electron microscopy and immunohistochemistry. HES storage was dose-dependent, decreased in all organs with time and was greater in patients suffering from pruritus. We conclude that tissue deposition of HES is transitory and dose-dependent, with differences between subjects in severity and duration.
Sirtl
C
C
Department of Anaesthesiology, St Josef-Hospital, Ruhr-Universität Bochum, Germany.
Laubenthal
H
H
Zumtobel
V
V
Kraft
D
D
Jurecka
W
W
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D011537:Pruritus / Q000139:chemically induced* / Q000473:pathology; D012189:Retrospective Studies; D014018:Tissue Distribution
D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes