[Comparison of 201Tl-SPECT and MRI using Gd-DTPA for glioma].
201Tl-SPECT was performed in 25 patients with a pathological diagnosis of glioma. The lesion-to-normal (L/N) ratio of the glioblastoma group (n = 7) was found to be higher than that of the low-grade glioma group (n = 7; Mann-Whitney U-test, p < 0.0167). 201Tl accumulation in the tumor corresponded to contrast enhancement on MRI in 95% of cases. An insufficient blood-brain barrier was considered to be the primary contributor to 201Tl accumulation. In five cases, there was a discrepancy between the extent of 201Tl accumulation and the Gd-DTPA enhanced area. In these cases, the area of 201Tl accumulation was larger than the area of Gd-DTPA enhancement. This may result from damage to the blood-brain barrier that is not severe enough to be detected with Gd-DTPA or from additional factors other than change in the blood-brain barrier. 201Tl-SPECT is able to demonstrate the extent of glioma more accurately than contrast-enhanced MRI.
Yamada
T
T
Department of Radiology, Tohoku University School of Medicine.
Maruoka
S
S
Yamada
S
S
Sonobe
M
M
D001932:Brain Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003287:Contrast Media; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013793:Thallium; D015899:Tomography, Emission-Computed, Single-Photon
D003287:Contrast Media; D019275:Radiopharmaceuticals; C027549:thallium chloride; D013793:Thallium; D019786:Gadolinium DTPA