[Combined action of xenobiotics on the status of the antioxidant system of the body].
The chronic combined inhalational effect of lead, radon, nitric oxides (NO, NO2) and amorphous hydrophobic silicon dioxide on the activity of enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase, g-glutamyl transpeptidase, peroxidases and also on the protein reducing glutathione concentration of the mongrel male-rat was investigated. It has been shown that organism antioxidant system displaces activity toward of the most widespread xenobiotics, expressing the rising of itself activity during whole experience. The dynamic of changes of the antioxidant system activity also was analyzed. Moreover, at the first step of our experience there was the sharp activity rise as a result of action of the mechanisms of adaptation and compensation. At the following intermediate step we were observing exhaustion of the antioxidant system and including of additional powers at the last step.
Hirin
S V
SV
Ukrainian Research Institute of Industrial Medicine, Ministry of Public Health of Ukraine, Kryvyi Rig.
D000280:Administration, Inhalation; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D007854:Lead / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology; D011886:Radon / Q000494:pharmacology; D051381:Rats; D012822:Silicon Dioxide / Q000494:pharmacology; D015262:Xenobiotics / Q000494:pharmacology*
D000975:Antioxidants; D015262:Xenobiotics; D007854:Lead; D009569:Nitric Oxide; D012822:Silicon Dioxide; D011886:Radon