Rabies vaccine. Developments employing molecular biology methods.
Rabies vaccines produced by means of molecular biology are described. Recombinant vaccines employing either viruses as vectors (vaccinia, adenovirus, poxvirus, baculovirus, plant viruses) or a plasmid vector carrying the rabies virus glycoprotein gene are discussed. Synthetic peptide technology directed to rabies vaccine production is also presented.
Paolazzi
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Servicio Vacuna Antirrábica, Instituto Nacional de Producción de Biológicos, A.N.L.I.S., Buenos Aires, Argentina. mhedrera@ffyb.UBA.AR
Pérez
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De Filippo
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D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000956:Antigens, Viral; D016367:Baculoviridae / Q000235:genetics; D004274:DNA, Recombinant / Q000235:genetics; D005822:Genetic Vectors; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D010942:Plant Viruses / Q000235:genetics; D011212:Poxviridae / Q000235:genetics; D011818:Rabies / Q000517:prevention & control* / Q000821:virology*; D011819:Rabies Vaccines / Q000235:genetics*; D014614:Vaccines, Synthetic / Q000235:genetics; D014616:Vaccinia virus / Q000235:genetics; D014759:Viral Envelope Proteins / Q000235:genetics
D000956:Antigens, Viral; D004274:DNA, Recombinant; D006023:Glycoproteins; D011819:Rabies Vaccines; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus