Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina.
A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0.03-0.07 microgram ml-1 against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.
Strobel
Gary A
GA
Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA.
Miller
R Vincent
RV
Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA.
Martinez-Miller
Concepcion
C
Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA.
Condron
Margaret M
MM
Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Teplow
David B
DB
Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Hess
W M
WM
Department of Botany and Range Science, Brigham Young University, Provo, UT 84601, USA.
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003470:Culture Media; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D010456:Peptides, Cyclic; C122176:cryptocandin