title: Anger in healthy men: a PET study using script-driven imagery.
abstract: BACKGROUND
  An understanding of the neurobiological basis of normal emotional processing is useful in formulating hypotheses regarding the pathophysiology of psychiatric illnesses.
  
  
  METHODS
  This study examined the mediating functional neuroanatomy of anger in eight healthy men. Narrative scripts were developed from autobiographical information to induce anger and neutral states. The subjects imagined the content of the narrative scripts to induce anger during positron emission tomography to measure normalized regional cerebral blood flow (rCBF). Psychophysiologic responses and subjective ratings of emotional state were measured for each condition. Statistical parametric maps were constructed to reflect the Anger versus Neutral state contrast.
  
  
  RESULTS
  Anger was associated with activation of the left orbitofrontal cortex, right anterior cingulate cortex affective division, and bilateral anterior temporal poles.
  
  
  CONCLUSIONS
  These results suggest that the subjective experience of anger is associated with rCBF increases in anterior paralimbic regions of the brain.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Dougherty
authors.forename: L M
authors.initials: LM
authors.lastname: Shin
authors.forename: N M
authors.initials: NM
authors.lastname: Alpert
authors.forename: R K
authors.initials: RK
authors.lastname: Pitman
authors.forename: S P
authors.initials: SP
authors.lastname: Orr
authors.forename: M
authors.initials: M
authors.lastname: Lasko
authors.forename: M L
authors.initials: ML
authors.lastname: Macklin
authors.forename: A J
authors.initials: AJ
authors.lastname: Fischman
authors.forename: S L
authors.initials: SL
authors.lastname: Rauch
mesh_terms: D000328:Adult; D000786:Anger / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007092:Imagination; D008032:Limbic System / Q000502:physiology; D008297:Male; D012016:Reference Values; D014055:Tomography, Emission-Computed