The coronin family of actin-associated proteins.
Coronin was first isolated from Dictyostelium, but similar proteins have been identified in many species and individual cell types. The coronin-like protein in yeast promotes actin polymerization and also interacts with microtubules. Dictyostelium mutants lacking coronin are impaired in cytokinesis and all actin-mediated processes. Analysis of coronin-GFP (green-fluorescent protein) fusions and knockout mutants shows that coronin participates in the remodelling of the cortical actin cytoskeleton that is responsible for phagocytosis and macropinocytosis. Likewise, in mammalian neutrophils, a coronin-like protein is also associated with the phagocytic apparatus. The diversity of function in this family of actin-associated proteins is just beginning to be explored.
de Hostos
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Tropical Disease Research Unit, University of California, San Francisco, VAMC 113B, 4150 Clement St, San Francisco, CA 94121, USA. hostos@socrates.ucsf.edu
D000199:Actins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001704:Biopolymers; D004023:Dictyostelium / Q000235:genetics / Q000378:metabolism; D004705:Endocytosis; D005544:Forecasting; D005656:Fungal Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008322:Mammals / Q000378:metabolism; D008840:Microfilament Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology / Q000648:ultrastructure; D008870:Microtubules / Q000378:metabolism; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D000199:Actins; D001704:Biopolymers; D005656:Fungal Proteins; D015801:Helminth Proteins; D008840:Microfilament Proteins; C072061:coronin proteins