title: [Brain oxygen extraction fraction as an indicator for shunting operation in normal pressure hydrocephalus].
abstract: It is still difficult for neurosurgeons to determine which patients with suspected idiopathic normal pressure hydrocephalus (NPH) should undergo shunting. We need to find a more accurate indicator to predict the effect of shunting. We introduced a new preoperative examination of brain oxygen extraction fraction (OEF) and examined whether preoperative OEF value is effective for prediction of the surgical results. Global brain OEF was calculated from oxygen contents of arterial blood (AO2) and jugular venous blood (VjO2) selectively sampled from the right jugular bulb using the Seldinger method: OEF = (AO2-VjO2)/AO2. Since June 1996 we have treated 9 patients suspected of idiopathic and 10 patients suspected of secondary NPH. OEF in non-NPH patients with dilated ventricle (n = 10) and in infarct patients (n = 85) were 0.33 +/- 0.02 and 0.38 +/- 0.06, respectively. In contrast, OEF increased both in idiopathic NPH (0.42 +/- 0.04) and secondary NPH (0.45 +/- 0.02), and the NPH patients with the higher preoperative OEF values showed the better symptomatic recovery. The present study suggests that brain function may be reversible when OEF can be increased and that OEF can be a useful indicator for predicting the effect of a shunting operation in NPH.
authors.affiliation: Department of Neurosurgery, Kochi Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mima
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Kazita
authors.forename: T
authors.initials: T
authors.lastname: Nakajoh
authors.forename: K
authors.initials: K
authors.lastname: Chokyu
authors.forename: K
authors.initials: K
authors.lastname: Mori
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism*; D002302:Cardiac Output; D002557:Cerebrospinal Fluid Shunts; D002560:Cerebrovascular Circulation; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D007427:Intracranial Pressure; D008875:Middle Aged; D010092:Oximetry; D010101:Oxygen Consumption; D018579:Patient Selection