title: Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders.
abstract: The therapeutic effect of methylcobalamin (Met-12) on sleep-wake rhythm disorders was examined in a double-blind test. In the test group which was given a large dosage, a higher percentage of improvement was found compared to the control group with a small dosage, although the difference was not significant. The test group inconsistently showed significant improvement in both the sleep-wake cycle parameters and in clinical symptoms. The tendency was for the results to show a beneficial effect of Met-12 on rhythm disorders. However, because the percentage of improvement was low and significant improvement was inconsistent, Met-12 might be considered to have a low therapeutic potency and possible use as a booster for other treatment methods of the disorders.
authors.affiliation: National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Okawa
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Mishima
authors.forename: H
authors.initials: H
authors.lastname: Yamadera
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ishizuka
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Higuchi
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: H
authors.initials: H
authors.lastname: Furuta
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Kuroda
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Uchimura
authors.forename: H
authors.initials: H
authors.lastname: Nagayama
authors.forename: T
authors.initials: T
authors.lastname: Miike
authors.forename: K
authors.initials: K
authors.lastname: Kamei
mesh_terms: D000339:Affect / Q000187:drug effects; D001143:Arousal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D012894:Sleep Stages / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014851:Wakefulness / Q000187:drug effects*
chemical_list: C019476:mecobalamin; D014805:Vitamin B 12