title: The angiotensin-converting enzyme genotype and microalbuminuria in autosomal dominant polycystic kidney disease.
abstract: Autosomal dominant polycystic kidney disease (AD-PKD) has a variable clinical course. Clinical parameters associated with a worse prognosis are hypertension and proteinuria or microalbuminuria (MA). Because chronic stimulation of the renin-angiotensin system is likely to be present in ADPKD patients, the effect of the angiotensin-converting enzyme insertion/deletion (ACE I/D) genotype on the variability of these clinical parameters was examined in untreated ADPKD patients. Proteinuria and MA were determined in 24-h urine collections. BP measurements were performed with an ambulatory monitor, over 24 h. With analysis of covariance, the ACE genotype was found to be significantly associated with MA, corrected for age, gender, GFR, mean arterial pressure, body surface area, and urinary Na+ excretion (P < 0.05). The patients homozygous for the deletion (DD) had the highest rate of MA (P < 0.05) compared to the patients homozygous for the insertion (II). There was no relationship between the ACE genotype and BP or renal function. A significant positive correlation was found between MA and mean arterial pressure (r = 0.31, P < 0.05), whereas a significant negative correlation was found between MA and renal function (r = -0.28, P < 0.05). In conclusion, in ADPKD patients, MA is partly determined by the ACE I/D polymorphism. Because MA is associated with an enhanced progression toward renal failure, the ACE genotype could help in identifying patients at risk for a worse prognosis.
authors.affiliation: Department of Nephrology, Leiden University Medical Centre, The Netherlands. MEAvdHulst@nephrology.azl.nl
authors.forename: M A
authors.initials: MA
authors.lastname: van Dijk
authors.forename: D J
authors.initials: DJ
authors.lastname: Peters
authors.forename: M H
authors.initials: MH
authors.lastname: Breuning
authors.forename: P C
authors.initials: PC
authors.lastname: Chang
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000201:enzymology* / Q000235:genetics*; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016891:Polycystic Kidney, Autosomal Dominant / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D011379:Prognosis; D011507:Proteinuria / Q000201:enzymology / Q000235:genetics
chemical_list: D007703:Peptidyl-Dipeptidase A