Evaluation of the genotoxicity of 2,4-dichlorophenoxyacetic acid and its derivatives in mammalian cell cultures.
2,4-dichlorophenoxyacetic acid and its derivatives (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. The genetic toxicity of an ester (2,4-D 2-butoxyethylester) and two salts (2,4-D isopropylamine and 2,4-D triisopropanolamine) was investigated in cultured mammalian cells. The end points used were the induction of chromosomal aberrations in primary cultures of rat lymphocytes and forward mutations at the HGPRT locus of Chinese hamster ovary cells. There was no evidence of genotoxicity for the test materials in the experimental systems used. These results were consistent with the general lack of genotoxic potential for 2,4-D in a number of other test systems.
Gollapudi
B B
BB
Dow Chemical, Building 1803, Midland, MI 48674, USA.
Charles
J M
JM
Linscombe
V A
VA
Day
S J
SJ
Bus
J S
JS
D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000633:toxicity*; D000818:Animals; D016466:CHO Cells; D002869:Chromosome Aberrations; D006224:Cricetinae; D006540:Herbicides / Q000633:toxicity*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008214:Lymphocytes / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D051381:Rats
D006540:Herbicides; D009153:Mutagens; C032767:butoxyethanol ester of 2,4-dichlorophenoxyacetic acid; D015084:2,4-Dichlorophenoxyacetic Acid; D007041:Hypoxanthine Phosphoribosyltransferase