Cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis.
In order to find out the relationship between the cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis, 10 cases of asymptomatic cerebral infarction and 10 age-matched control subjects were studied. The cerebrovascular acetazolamide reactivity was measured using xenon computed tomography method. As markers of platelet function, the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were determined. The cerebrovascular acetazolamide reactivity was significantly lower in the asymptomatic cerebral infarction group than in the control group. The plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were higher in the asymptomatic cerebral infarction group than in the control group. There was a significant negative correlation between the cerebrovascular acetazolamide reactivity and the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2. The low cerebrovascular acetazolamide reactivity is considered to be related to platelet activation in asymptomatic cerebral thrombosis.
Oishi
M
M
Department of Neurology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan.
Mochizuki
Y
Y
D000086:Acetazolamide; D000368:Aged; D001160:Arterioles / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010978:Platelet Factor 4 / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014980:Xenon Radioisotopes; D001620:beta-Thromboglobulin / Q000032:analysis
D002257:Carbonic Anhydrase Inhibitors; D014980:Xenon Radioisotopes; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000086:Acetazolamide