title: Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation.
abstract: The inhibiting and disaggregating effect of desalted and fractionated herbal extract of Galega officinalis L. on platelet aggregation in vitro is studied. At a concentration of 35 micrograms/ml in a platelet-rich plasma (PRP) the fraction inhibits 50% of aggregation by ADP and at 125 micrograms/ml PRP it inhibits fully the aggregation of PRP by ADP. At a concentration of 40 micrograms/ml PRP the fraction inhibits the initiation of platelet aggregation by collagen and at 50 micrograms/ml PRP inhibits the initiation of aggregation by thrombin. At a concentration of 65 micrograms/ml PRP the fraction can disaggregate 50% of the aggregated platelet-rich plasma by ADP and 25% of aggregated PRP by collagen.
authors.affiliation: Department of Biophysics, Faculty of Medicine, Thracian University, Stara Zagora, Bulgaria.
authors.forename: A T
authors.initials: AT
authors.lastname: Atanasov
authors.forename: V
authors.initials: V
authors.lastname: Spasov
mesh_terms: D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*
chemical_list: D006146:Guanidines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C074315:galegine