title: Alterations of nasal mucociliary transport in patients with hypertrophy of the inferior turbinates, deviations of the nasal septum and chronic sinusitis.
abstract: Mucociliary transport (MCT) represents the first barrier of the nasal fossae and paranasal sinuses against various biological and physical insults. We studied the nasal MCT time using a mixture of vegetable charcoal powder and 3% saccharin in three groups of patients suffering from hypertrophy of the inferior turbinates, deviations of the nasal septum or chronic sinusitis. The mean values of the nasal MCT in the first two groups were practically identical to the normal ones. In contrast, significantly delayed times were found in patients with chronic sinusitis (P < 0.01). Findings indicate that this delay is determined by an increase in viscoelasticity of the mucus following the acute release of mediators of inflammation, together with a reduction in the periciliary stratum, which slows down the metachronous wave of the MCT.
authors.affiliation: E.N.T. Institute, Policlinico Le Scotte, University of Siena, V.le Bracci, I-53100 Siena, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Passàli
authors.forename: R
authors.initials: R
authors.lastname: Ferri
authors.forename: G
authors.initials: G
authors.lastname: Becchini
authors.forename: G C
authors.initials: GC
authors.lastname: Passàli
authors.forename: L
authors.initials: L
authors.lastname: Bellussi
mesh_terms: D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000503:physiopathology*; D002908:Chronic Disease; D002925:Ciliary Motility Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology; D009297:Nasal Mucosa / Q000503:physiopathology; D009300:Nasal Septum / Q000503:physiopathology*; D012016:Reference Values; D012852:Sinusitis / Q000503:physiopathology*; D014420:Turbinates / Q000503:physiopathology*