title: Verbal working memory deficit in Parkinson's disease subjects.
abstract: The aim of the present work was to evaluate verbal working memory in patients affected by Parkinson's disease (PD). In particular, tests that explore the functionality of the Articulatory Loop and of the Central Executive during verbal tasks were given. PD patients displayed normal phonological similarity, word length and word frequency effects in a Word span task, thus demonstrating adequate retention capacity of the phonological store, normal functioning of the articulatory rehearsal mechanism and a normal contribution of lexical-semantic knowledge to verbal immediate recall. In the Brown-Peterson task, PD patients showed abnormal performance decay on the letter recall task when articulatory rehearsal was inhibited by a serial subtraction concurrent task. These data provide evidence for normal functioning of the Articulatory Loop in PD patients. However, when the verbal recall task is more attention demanding, PD patients show deficient performance levels, presumably due to depleted processing resources by the Central Executive.
authors.affiliation: IRCCS S. Lucia, Rome, Italy. memolab@hsantalucia.it
authors.forename: A M
authors.initials: AM
authors.lastname: Graceffa
authors.forename: G A
authors.initials: GA
authors.lastname: Carlesimo
authors.forename: A
authors.initials: A
authors.lastname: Peppe
authors.forename: C
authors.initials: C
authors.lastname: Caltagirone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention; D006801:Humans; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000523:psychology*; D013647:Task Performance and Analysis; D014706:Verbal Learning / Q000502:physiology; D014825:Vocabulary