title: Adenosquamous carcinoma of the rectum showing endocrine-cell differentiation: report of a case.
abstract: OBJECTIVE
  Previous records of adenosquamous carcinomas with endocrinologic features rarely have been reported. Although the disease behaves in an extremely aggressive manner, chemotherapy after surgery has never been proposed. We used regional chemotherapy for treatment of unresectable liver metastases.
  
  
  METHODS
  Hartmann colostomy was performed and 5-fluorouracil was infused into the hepatic artery for 15 weeks after the operation.
  
  
  RESULTS
  Multiple liver metastases were present at the initial operation. Three months after the start of the chemotherapy, computed tomography showed that metastatic tumors in the liver had disappeared. The patient survived 18 months after the initial operation.
  
  
  CONCLUSIONS
  This case report describes the first successful treatment with adjuvant regional chemotherapy of a patient who had an adenosquamous carcinoma with endocrine-cell differentiation in the rectum and liver metastases.
authors.affiliation: Department of Surgery II, Asahikawa Medical College, Hokkaido, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Kakisaka
authors.forename: Y
authors.initials: Y
authors.lastname: Tokusasi
authors.forename: N
authors.initials: N
authors.lastname: Miyokawa
authors.forename: S
authors.initials: S
authors.lastname: Kasai
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005472:Fluorouracil / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil