The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy.
Thrombotic microangiopathy is an uncommon complication of cyclosporin immunosuppression following renal transplantation. We present a 15-year-old girl who developed clinical features of acute rejection, but in whom an early biopsy revealed thrombotic microangiopathy, allowing a change to FK506 immunosuppression resulting in excellent graft recovery.
Burke
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GA
Paediatric Department, Children's Renal Unit, The Richard Bright Kidney Unit, Southmead Hospital NHS Trust, Bristol BS10 5NB, UK,
McGraw
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ME
MacIver
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AG
D000293:Adolescent; D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000098:blood supply*; D019233:Retreatment; D016559:Tacrolimus / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus