title: Spectral analysis of laser-Doppler perfusion signal measured during thermal test.
abstract: The method of spectral analysis of laser-Doppler perfusion signal measured during thermal test is proposed. During three 20 min phases with 40, 5, and 40 degrees C of thermal test laser-Doppler perfusion signal was recorded. For each signal phase frequency spectra were calculated using the FFT method. Quantitative parameter Spectral Factor for results evaluation was proposed. In total 94 patients were measured: 69 with Raynaud's phenomenon and 25 normal subjects. Additionally in 18 Raynaud's patients the influence of Nifedipine was studied. Results suggest that proposed parameter is able to differentiate between Raynaud's patients and normal subjects and that is useful for evaluation of Nifedipine effectiveness. However, further studies are needed to improve the method to differentiate between primary and secondary Raynaud's patients.
authors.affiliation: Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland. roman@hrabia.ibib.waw.pl
authors.forename: R
authors.initials: R
authors.lastname: Maniewski
authors.forename: P
authors.initials: P
authors.lastname: Leger
authors.forename: P
authors.initials: P
authors.lastname: Lewandowski
authors.forename: A
authors.initials: A
authors.lastname: Liebert
authors.forename: P
authors.initials: P
authors.lastname: Bendayan
authors.forename: H
authors.initials: H
authors.lastname: Boccalon
authors.forename: L
authors.initials: L
authors.lastname: Bajorski
authors.forename: K O
authors.initials: KO
authors.lastname: Möller
mesh_terms: D000328:Adult; D000465:Algorithms; D016022:Case-Control Studies; D003080:Cold Temperature; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009543:Nifedipine; D011446:Prospective Studies; D011928:Raynaud Disease / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D009543:Nifedipine