title: Neuroendocrine differentiation of a metastatic basal cell carcinoma in a patient with basal cell nevus syndrome.
abstract: A 48 year-old white male with basal cell nevus syndrome presented with a metastatic basal cell carcinoma with neuroendocrine features. The tumor manifested aggressive behavior, having deep local invasion and metastases to para-aortic lymph nodes and bone. Neuroendocrine differentiation has rarely been associated with basal cell carcinoma. The histologic, immunohistochemical, and electron microscopic studies of this rare tumor are described.
authors.affiliation: Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City 66160, USA. otawfik@kumc.edu
authors.forename: O
authors.initials: O
authors.lastname: Tawfik
authors.forename: J M
authors.initials: JM
authors.lastname: Casparian
authors.forename: N
authors.initials: N
authors.lastname: Garrigues
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: T
authors.initials: T
authors.lastname: Kestenbaum
authors.forename: F
authors.initials: F
authors.lastname: Chamberlin
authors.forename: Q S
authors.initials: QS
authors.lastname: Khan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001478:Basal Cell Nevus Syndrome / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D013125:Spinal Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010751:Phosphopyruvate Hydratase