title: Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).
abstract: A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.
authors.affiliation: Pharmaceutical Discovery Division, Ribi ImmunoChem Research, Inc., Hamilton, MT 59840, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Johnson
authors.forename: C G
authors.initials: CG
authors.lastname: Sowell
authors.forename: C L
authors.initials: CL
authors.lastname: Johnson
authors.forename: M T
authors.initials: MT
authors.lastname: Livesay
authors.forename: D S
authors.initials: DS
authors.lastname: Keegan
authors.forename: M J
authors.initials: MJ
authors.lastname: Rhodes
authors.forename: J T
authors.initials: JT
authors.lastname: Ulrich
authors.forename: J R
authors.initials: JR
authors.lastname: Ward
authors.forename: J L
authors.initials: JL
authors.lastname: Cantrell
authors.forename: V G
authors.initials: VG
authors.lastname: Brookshire
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D011817:Rabbits; D013329:Structure-Activity Relationship; D013403:Sugar Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D013403:Sugar Phosphates; D013745:Tetanus Toxoid; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D005944:Glucosamine