Experimental investigation of I-123 iodoamphetamine in the detection of lung cancer.
Experimentally we investigated the detection of lung cancer with N-isopropyl-p-I-123-iodoamphetamine (I-123 IMP). Various tumors including Lewis lung cancer were used as tumor models. Serial images were obtained. Biodistribution of Lewis lung cancer was performed. In Lewis lung cancer good visualization as in B-16 melanoma and high tumor accumulation were found with IMP. In conclusion, due to its greater accumulation almost equivalent to that in melanotic melanoma, I-123 IMP may have a role in the detection of lung cancer.
Watanabe
N
N
Department of Radiology, Toyama Medical and Pharmaceutical University, Toyama City, Japan. nw31456@ms.toyama-mpu.ac.jp
Yokoyama
K
K
Shuke
N
N
Kinuya
S
S
Aburano
T
T
Tonami
N
N
Seto
H
H
Goodwin
D A
DA
D000818:Animals; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine / Q000493:pharmacokinetics; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D020367:Iofetamine