[Cytogenic characteristics and virogenic status of lymphoid cells from malignant baboon lymphomas].
Four lymphoid cell cultures obtained from Papio hamadryads with malignant lymphomas were studied. The cultured cells produced two lymphotropic EBV-like herpes virus of Papio (HVP) and T-lymphotropic monkey retrovirus STLV-1 (HTLV-1 family) or HVP alone. More than 100 subcultured cell lines were shown to remain mixed B- and T-cellular, the levels of T cells of different subpopulations were 15-50%. Cytogenetic investigations showed that one of the 4 cultures was tumorogenic and the others were derived from the normal cells of monkeys with malignant lymphomas. It is suggested that the presence of a cultural virus (viruses) may affect the karyotypes of cells.
Agrba
V Z
VZ
Medvedeva
N M
NM
Iakovleva
L A
LA
Chikobava
M G
MG
Araviashvili
D E
DE
Timanovskaia
V V
VV
Lapin
B A
BA
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology / Q000821:virology*; D015490:HTLV-I Infections / Q000473:pathology / Q000662:veterinary / Q000821:virology; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary / Q000821:virology; D006568:Herpesvirus 1, Cercopithecine / Q000302:isolation & purification*; D008223:Lymphoma / Q000473:pathology* / Q000662:veterinary / Q000821:virology; D010215:Papio; D015303:Simian T-lymphotropic virus 1 / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology*; D014407:Tumor Cells, Cultured