Highly sequence selective nonmacrocyclic two-armed receptors for peptides.
Simple nonmacrocyclic two armed receptors have been synthesized to create a new class of sequence-selective receptors for peptides. Screening several examples of these simple compounds against a 24,389-member library of N-acetyl tripeptides revealed novel binding properties.
Iorio
E J
EJ
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Still
W C
WC
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003514:Cyclohexylamines / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000378:metabolism; D019151:Peptide Library; D010455:Peptides / Q000378:metabolism*
D000814:Aniline Compounds; D002614:Chelating Agents; D003514:Cyclohexylamines; D009842:Oligopeptides; D019151:Peptide Library; D010455:Peptides