Serial changes in cardiovascular and renal function of rabbits ingesting a high-fat, high-calorie diet.
To explore the mechanisms of obesity-induced hypertension we analyzed the sequential changes in cardiovascular and renal function in adult rabbits switched to high-fat diet (HFD) for 8 weeks. Animals were housed in metabolic cages for continuous 24-h recording of arterial pressure by telemetry and daily urine collection. High-fat diet induced a progressive increase in body weight (+47%) and a rapid rise in mean arterial pressure, heart rate, and glomerular filtration rate that stabilized, respectively, at 14%, 31% and 68% greater than control values. Time-course analysis of changes in blood pressure may reveal two components of obesity-induced hypertension, an early phase related to HFD itself and a later phase related to weight gain.
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Institute of Physiology, University of Fribourg, Switzerland.
Tempini
A
A
Montani
J P
JP
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004041:Dietary Fats / Q000009:adverse effects*; D002149:Energy Intake / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D009765:Obesity / Q000503:physiopathology; D011817:Rabbits; D012964:Sodium / Q000097:blood / Q000378:metabolism; D013686:Telemetry; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000502:physiology; D015430:Weight Gain / Q000502:physiology
D004041:Dietary Fats; D012964:Sodium