[Heterogeneity of chloroquine resistant malaria in Senegal].
In order to evaluate the in vivo efficacy of chloroquine in the treatment of P. falciparum malaria, studies have been carried out in Richard-Toll, Fatick and Tambacounda, 3 areas where dynamics of transmission, population movements, as well as prophylactic and curative practises are different. Failure rates in treatment were 13% in site 1 (Richard-Toll) where medical pressure and population movements are high. In sites 2 and 3 (Fatick and Tambacounda), the failure rate was 3%. Even if medical pressure is lower in the latter site (Tambacounda), the higher transmission could be a factor in the spreading of resistance. A surveillance system and better use of chloroquine must be undertaken.
Gaye
O
O
Service de parasitologie, Faculté de médecine, UCAD, Dakar, Sénégal. ogaye@ucad.refer.sn
Soumaré
M
M
Sambou
B
B
Faye
O
O
Dieng
Y
Y
Diouf
M
M
Bah
I B
IB
Dieng
T
T
N'dir
O
O
Diallo
S
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000635:transmission; D012675:Senegal; D017211:Treatment Failure
D002738:Chloroquine