Modification of polysulfone with phospholipid polymer for improvement of the blood compatibility. Part 1. Surface characterization.
To improve the surface blood compatibility of polysulfone (PSf) membranes, we prepared novel polymeric additives which have suitable blood compatibility. They were polymers with a phosphorylcholine group, a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit. The MPC polymer could be blended with polysulfone by a solvent evaporation method during membrane processing, and a transparent membrane could be obtained. The mechanical properties of the blend membrane were similar to that of the original PSf membrane. Surface analysis of the blend membrane by X-ray photoelectron spectroscopy and dynamic contact angle measurement revealed that the MPC unit in the polymeric additive was concentrated on the surface of the membrane. The blend membrane significantly reduced plasma protein adsorption compared with that of the PSf membrane.
Ishihara
K
K
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, Japan.
Fukumoto
K
K
Iwasaki
Y
Y
Nakabayashi
N
N
D000327:Adsorption; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001769:Blood / Q000187:drug effects*; D008567:Membranes, Artificial; D010743:Phospholipids / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013450:Sulfones / Q000737:chemistry*; D013499:Surface Properties
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D010743:Phospholipids; D011109:Polymethacrylic Acids; D013450:Sulfones