The infant with a vascular tumor.
Vascular birthmarks look alike in various tints of blue, pink, or red. These anomalies are either vascular tumors or vascular malformations. Hemangioma is the most common vascular tumor of infancy, typically appearing in the neonatal period. Hemangiomas grow rapidly during the first year of life and regress slowly during childhood. Treatment is indicated for problematic or endangering hemangiomas, usually the administration of corticosteroids or interferon-alfa, and in some instances, embolization or surgical resection. The more aggressive and rare vascular tumors, kaposiform hemangioendothelioma and tufted angioma, are often associated with thrombocytopenia and coagulopathy (Kasabach-Merritt phenomenon) and less responsive to pharmacological therapy. Vascular tumors, particularly hemangioma, are often confused with vascular malformations; although etiology, histology, and clinical behavior are quite different. Vascular lesions should be biopsied if there is any suspicion of malignancy.
Mueller
B U
BU
Department of Medicine, Harvard Medical School, Children's Hospital, Boston, MA 02115, USA. mueller_b@a1.tch.harvard.edu
Mulliken
J B
JB
D001808:Blood Vessels / Q000002:abnormalities; D003937:Diagnosis, Differential; D006391:Hemangioma; D006801:Humans; D007231:Infant, Newborn; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000628:therapy