Expression of the chicken angiotensin II receptor: atypical pattern compared to its mammalian homologues.
We have recently cloned and characterized pharmacologically a chicken angiotensin II receptor (cAT). To evaluate its putative role in developmental processes, we investigated its spatio-temporal distribution in the chicken embryo up to E14. The cAT mRNA is expressed in a developmental manner in the mesonephros and allantois, as well as in the heart, branchial arches or limbs. These results, the first to report the embryonic distribution of an angiotensin receptor in a non-mammalian species, show that its expression pattern does not correspond to either one of the two angiotensin receptor types in mammalian species.
Kempf
H
H
INSERM U36, Collège de France, Paris. hkempf@infobiogen.fr
Corvol
P
P
Gasc
J M
JM
D000482:Allantois / Q000196:embryology / Q000378:metabolism; D000818:Animals; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D017403:In Situ Hybridization; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D008322:Mammals; D008648:Mesoderm / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000378:metabolism
D011945:Receptors, Angiotensin