Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats.
BACKGROUND
Comparative evaluation of propacetamol and morphine on the cold restraint stress ulcers in rats.


METHODS
The present study compared the effects of propacetamol hydrochloride (250 and 500 mg.kg-1 i.p.) and morphine hydrochloride (10 mg.kg-1 i.p.) against gastric mucosal damage induced by cold/restraint stress (4 degrees C for 3 h) in rats. Morphometrical and histomorphological studies were carried out. Mean ulcer number and length were calculated.


RESULTS
The results show that propacetamol in the lower dose tested decreases the ulcer number and length by 56.4% (p > 0.05) and by 68.94% (p < 0.01). After propacetamol 500 mg.kg-1 the ulcer number and length were found significantly decreased by 74.83% and 83.5%. Marked decrease was found in morphine-pretreated group (-77.03% and -85.09%). The morphometrical results have been confirmed histomorphologically.


CONCLUSIONS
It might be concluded that morphine (10 mg.kg-1) and propacetamol (500 mg.kg-1) are equipotent in their ability to prevent the stress ulceration in rats.
Marazova
K
K
Department of Pharmacology, Faculty of Medicine, Faculty Hospital S. Anna, Sofia, Bulgaria.
Klouchek
E
E
Popov
A
A
Frangov
P
P
Di Massa
A
A
D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003080:Cold Temperature / Q000009:adverse effects; D008297:Male; D011355:Prodrugs / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical / Q000009:adverse effects; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011355:Prodrugs; D000082:Acetaminophen; C063776:propacetamol