title: Changing reactivity of caprine and ovine mononuclear phagocytes throughout part of the life cycle of Oestrus ovis: assessment through spontaneous and inductible NO production.
abstract: The in vitro reactivity of monocyte-derived macrophages (MDM) from Oestrus ovis (O. ovis) artificially infested lambs and kids was determined by measuring their production of nitric oxide (NO) during the course of infestation. In both species, crude antigenic preparations obtained from O. ovis first instar larvae (L1) were found to significantly (P < 0.01) inhibit this NO production, whereas O. ovis second instar (L2) extract stimulated it. Furthermore, this NO production by MDM decreased during infestation and was related to blood eosinophilia. It appears that crude antigenic extract from O. ovis modified the NO activity of macrophages from lambs and kids infested with O. ovis larvae.
authors.affiliation: Laboratoire associé Inra de physiopathologie respiratoire des ruminants, Ecole nationale vétérinaire, Toulouse, France. c.duranton@envt.fr
authors.forename: C
authors.initials: C
authors.lastname: Duranton
authors.forename: P
authors.initials: P
authors.lastname: Dorchies
authors.forename: S
authors.initials: S
authors.lastname: Grand
authors.forename: C
authors.initials: C
authors.lastname: Lesure
authors.forename: I P
authors.initials: IP
authors.lastname: Oswald
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004175:Diptera / Q000254:growth & development*; D004478:Ectoparasitic Infestations / Q000503:physiopathology / Q000662:veterinary*; D004804:Eosinophils / Q000502:physiology; D015511:Goat Diseases / Q000469:parasitology / Q000503:physiopathology*; D006041:Goats; D007814:Larva; D007958:Leukocyte Count; D008018:Life Cycle Stages; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology*; D009569:Nitric Oxide / Q000096:biosynthesis; D009573:Nitrites / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology / Q000503:physiopathology*
chemical_list: D009573:Nitrites; D009569:Nitric Oxide