Ovarian responses to hCG stimulation: insulin resistance/hyperinsulinaemia vs. insulin deficiency.
Polycystic ovary syndrome is a heterogeneous disorder characterized by signs and symptoms of hyperandrogenism and insulin resistance. We present the clinical and hormonal features in an adolescent girl who had distinct intervals of insulin deficiency and insulin resistance/hyperinsulinaemia. This case report confirms that insulin resistance/hyperinsulinaemia exacerbates ovarian hyperandrogenism.
Witchel
S F
SF
Division of Paediatric Endocrinology, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Arslanian
S
S
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D001786:Blood Glucose / Q000032:analysis; D006063:Chorionic Gonadotropin; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use; D007333:Insulin Resistance; D007986:Luteinizing Hormone / Q000097:blood; D008687:Metformin / Q000627:therapeutic use; D010053:Ovary / Q000187:drug effects / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013268:Stimulation, Chemical; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D006063:Chorionic Gonadotropin; D007004:Hypoglycemic Agents; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D008687:Metformin