Differential regulation of enteric and systemic salmonellosis by slyA.
Mutation of slyA, which reduces Salmonella typhimurium virulence in mice, caused only minor attenuation of S. typhimurium virulence in orally inoculated calves. This correlated with modest reductions in intestinal invasion and enteropathogenic responses in bovine ligated ileal loops. slyA appears to regulate virulence genes involved in systemic, but not enteric, salmonellosis.
Watson
P R
PR
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom.
Paulin
S M
SM
Bland
A P
AP
Libby
S J
SJ
Jones
P W
PW
Wallis
T S
TS
D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000235:genetics; D002417:Cattle; D006460:Hemolysin Proteins / Q000235:genetics; D007413:Intestinal Mucosa / Q000473:pathology; D012481:Salmonella Infections, Animal / Q000473:pathology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D014157:Transcription Factors; D014774:Virulence
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D014157:Transcription Factors; C056785:salmolysin