title: Electrical and morphological changes of human erythrocytes under high hydrostatic pressure followed by dielectric spectroscopy.
abstract: The electrical and morphological properties of human erythrocytes under high hydrostatic pressure up to 500 MPa have been studied by dielectric spectroscopy. The pressure-induced changes in the dielectric behavior of erythrocyte suspensions indicate that hydrostatic pressure causes the change in cell shape from discoidal to spherical and hemolysis at 200-300 MPa, the formation of buds and spicular processes followed by vesiculation at 300-400 MPa, and the increase in the membrane capacitance at 400-500 MPa.
authors.affiliation: Institute for Chemical Research, Kyoto University, Uji, Japan. asami@tampopo.kuicr.kyoto-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Asami
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D004553:Electric Conductivity; D017097:Electric Impedance; D004907:Erythrocyte Deformability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000473:pathology; D004912:Erythrocytes / Q000166:cytology* / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D006874:Hydrostatic Pressure; D066298:In Vitro Techniques; D008858:Microscopy, Phase-Contrast; D008955:Models, Cardiovascular; D013057:Spectrum Analysis / Q000295:instrumentation
chemical_list: D006454:Hemoglobins