Structure-based design and synthesis of a novel class of Src SH2 inhibitors.
The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
Buchanan
J L
JL
ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts 02139-4234, USA.
Bohacek
R S
RS
Luke
G P
GP
Hatada
M
M
Lu
X
X
Dalgarno
D C
DC
Narula
S S
SS
Yuan
R
R
Holt
D A
DA
D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018909:src Homology Domains
D013844:Thiazoles