Detection of a Hodgkin/Reed-Sternberg cell specific immunoglobulin gene rearrangement in the serum DNA of a patient with Hodgkin's disease.
We analysed multiple serum samples from a patient with mixed cellularity Hodgkin's disease for the Hodgkin/Reed-Sternberg cell clone-specific rearranged Ig gene sequence. The clone-specific sequence could be detected in DNA extracted from a serum sample obtained during clinical relapse but not in serum samples obtained during or after treatment following relapse.
Kornacker
M
M
Department I of Internal Medicine, University of Cologne, Cologne, Germany.
Jox
A
A
Vockerodt
M
M
Tesch
H
H
Bohlen
H
H
Diehl
V
V
Wolf
J
J
D000328:Adult; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin / Q000235:genetics; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016539:Reed-Sternberg Cells / Q000473:pathology*; D017422:Sequence Analysis, DNA