[Biochemical parameters of the metabolism of the intercellular substance of connective tissue, correlating with morphometric signs of long bone lesions in an open aseptic fracture].
The aim of the research was experimental study of dynamics and correlative dependences between biochemical connective tissue matrix metabolism indices (blood serum collagenase, cathepsin B, elastase, antielastase activity, hydroxyproline fractions and glycosaminoglycans concentration) and tissue damage morphometric indices after long bone aseptic osteotomy of rat in terms 3 h-60 days. The most strong and significant correlation was found between cathepsin B, elastase activity indices and dimensions of bone marrow ischemic damage focuses and summarised periosteal regenerates volume in bone fragments.
Grigorovskiĭ
V V
VV
Ukrainian Research Institute for Traumatology and Orthopedics, MPH of Ukraine, Kyiv.
Magomedov
S
S
D000818:Animals; D001207:Asepsis; D001842:Bone and Bones / Q000098:blood supply / Q000378:metabolism*; D002401:Cathepsin B / Q000097:blood; D017364:Collagenases / Q000097:blood; D003238:Connective Tissue / Q000378:metabolism* / Q000473:pathology; D005597:Fractures, Open / Q000378:metabolism* / Q000473:pathology; D006025:Glycosaminoglycans / Q000097:blood; D007511:Ischemia / Q000097:blood / Q000473:pathology; D008297:Male; D010027:Osteotomy; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood; D051381:Rats
D006025:Glycosaminoglycans; D010196:Pancreatic Elastase; D002401:Cathepsin B; D017364:Collagenases