title: Osteoinductive bone graft substitutes for spinal fusion: a basic science summary.
abstract: An understanding of precise biologic mechanisms at work during spinal fusion healing is just beginning to evolve. Current molecular biology research has shown this process to be multifactorial and extremely complex. With the advent of improved animal models to study the biology of spinal fusion, essential information regarding the basic science behind arthrodesis has advanced knowledge of this process. Moreover, with advances in local gene therapy as well as osteoinductive proteins and osteoinductive carrier matrices, the orthopedic surgeon will soon enter into a new era of biologic manipulation for fusion.
authors.affiliation: Department of Orthopaedic Surgery, The Emory Spine Center, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Ludwig
authors.forename: S D
authors.initials: SD
authors.lastname: Boden
mesh_terms: D000818:Animals; D001695:Biology; D001857:Bone Matrix; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000627:therapeutic use; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation; D003648:Decalcification Technique; D004195:Disease Models, Animal; D015316:Genetic Therapy; D006801:Humans; D008967:Molecular Biology; D010012:Osteogenesis; D011994:Recombinant Proteins; D013123:Spinal Fusion / Q000379:methods*; D014945:Wound Healing
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D011994:Recombinant Proteins