High prevalence of activated protein C resistance due to factor V leiden mutation in cases of intrauterine fetal death.
OBJECTIVE
To test a possible association between activated protein C resistance and intrauterine fetal death.


METHODS
The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls.


RESULTS
Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P = 0.013).


CONCLUSIONS
Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.
Rothbart
H
H
Department of Obstetrics and Gynecology, Poriya Hospital, Tiberias, Israel.
Ohel
G
G
Younis
J
J
Lanir
N
N
Brenner
B
B
D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009154:Mutation
C095381:factor V Leiden; D005165:Factor V