Expression of histamine H1 and H2 receptors in human nasal mucosa.
mRNA encoding histamine H1 and H2 receptors were detected in the human nasal mucosa using reverse transcriptase-polymerase chain reaction. The possibility of local release in connection with specific target receptors suggests a role for histamine in the regulation of vascular tone, glandular secretion and epithelial functions.
Uddman
R
R
Department of Oto-rhino-laryngology, Malmö General Hospital, Sweden.
Möller
S
S
Cardell
L O
LO
Edvinsson
L
L
D000328:Adult; D017931:DNA Primers; D018076:DNA, Complementary; D004587:Electrophoresis, Agar Gel; D004848:Epithelium / Q000502:physiology; D005786:Gene Expression Regulation; D006632:Histamine / Q000502:physiology; D006801:Humans; D009297:Nasal Mucosa / Q000098:blood supply / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D012339:RNA, Ribosomal, 28S / Q000032:analysis; D012194:RNA-Directed DNA Polymerase; D011969:Receptors, Histamine H1 / Q000032:analysis* / Q000235:genetics; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000235:genetics; D012220:Rhinitis / Q000378:metabolism / Q000473:pathology; D017422:Sequence Analysis, DNA; D014666:Vasomotor System / Q000502:physiology
D017931:DNA Primers; D018076:DNA, Complementary; D012333:RNA, Messenger; D012339:RNA, Ribosomal, 28S; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; D012194:RNA-Directed DNA Polymerase