Molecular approaches to understanding organogenesis.
The elucidation of the molecular mechanisms of mammalian organogenesis is the foundation on which we can build an improved understanding of organ pathology and pathophysiology. This paper uses the lung and the pancreas as paradigms to demonstrate how advances in basic molecular developmental biology research has translated into new appreciation of, and even novel potential treatment strategies for, congenital anomalies and mature diseases of these organs.
Crisera
C A
CA
Laboratory of Developmental Biology and Repair, New York University Medical Center, NY 10016, USA.
Longaker
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MT
Gittes
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GK
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control; D005314:Embryonic and Fetal Development; D005260:Female; D006548:Hernia, Diaphragmatic / Q000196:embryology; D006801:Humans; D007515:Islets of Langerhans / Q000196:embryology; D008168:Lung / Q000002:abnormalities / Q000196:embryology*; D008967:Molecular Biology; D010179:Pancreas / Q000196:embryology*; D010190:Pancreatic Neoplasms; D011247:Pregnancy; D014138:Tracheoesophageal Fistula / Q000196:embryology