title: Possible mechanism of action of vanadium ions as an antidiabetic agent.
abstract: Vanadium compounds, at much higher concentrations than they are typically ingested, are being considered for use in the treatment of diabetes mellitus. They exert an insulin-mimetic effect in an insulin-receptor-independent manner. In our study we obtained new data about the vanadium insulin-receptor-independent mechanism of action on cell membranes. When rat stomach smooth muscle samples are treated with NH4VO3 (10(-7) divided by 10(-5) this action is possibly exhibited with increased influx of Ca2+ through VDCa2+C.
authors.affiliation: Department of Physiology and Biophysics, Higher Medical Institute, Plovdiv.
authors.forename: K
authors.initials: K
authors.lastname: Terziyski
authors.forename: R
authors.initials: R
authors.lastname: Tzenova
authors.forename: E
authors.initials: E
authors.lastname: Milieva
authors.forename: S
authors.initials: S
authors.lastname: Vladeva
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D014639:Vanadium / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014639:Vanadium; D011972:Receptor, Insulin; D002118:Calcium