title: Is splenectomy for massive splenomegaly safe in children?
abstract: OBJECTIVE
  To study and analyze the causes, etiology, morbidity, mortality and therapeutic value of splenectomy performed for massive splenomegaly in children.
  
  
  METHODS
  The medical records of 115 children less than 18 years old who had splenectomy for various hematological disorders were reviewed. Twenty of them had splenectomy for massive splenomegaly (spleen weight > or =1,000 g). The records of these were reviewed for age at operation, gender, hematological diagnosis, indication for splenectomy, operative procedures, postoperative complications, and outcome.
  
  
  RESULTS
  Twenty children had splenectomy for massive splenomegaly. There were 16 males and 4 females. Their ages ranged from 4 to 15 years (mean 11.2). Twelve had sickle cell disease, 5 had sickle-beta-thalassemia, 1 had beta-thalassemia major, 1 had thalassemia intermediate, and 1 had chronic myeloid leukemia. The indications for splenectomy were hypersplenism in 11, recurrent splenic sequestration crisis in 8, and splenic abscess in 1. The transfusion requirements in the patient with beta-thalassemia major decreased markedly postoperatively from 18 transfusions/year to only 4 transfusions/year; and for those with hypersplenism, there was a marked improvement in their blood parameters following splenectomy. The patient with thalassemia intermediate required no more blood transfusions. There was no mortality. The immediate postoperative morbidity was 10% for those with massive splenomegaly compared with 6.3% for those with splenomegaly <1,000 g.
  
  
  CONCLUSIONS
  With good perioperative management, splenectomy in children with massive splenomegaly is both safe and effective.
authors.affiliation: Department of Surgery, Qatif Central Hospital, Saudi Arabia.
authors.forename: A H
authors.initials: AH
authors.lastname: Al-Salem
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009017:Morbidity; D009026:Mortality; D011183:Postoperative Complications; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects*; D013163:Splenomegaly / Q000601:surgery*; D013789:Thalassemia / Q000150:complications / Q000601:surgery