title: In vitro activities of fluoroquinolones against antibiotic-resistant blood culture isolates of viridans group streptococci from across Canada.
abstract: Among 418 blood culture isolates of viridans group streptococci obtained between 1995 and 1997, the in vitro rates of nonsusceptibility to penicillin, erythromycin, tetracycline, and trimethoprim-sulfamethoxazole were 28, 29, 24, and 14%, respectively. The most prevalent group (125 strains) was Streptococcus mitis, followed by Streptococcus sanguis (56 strains). For 236 (56%) strains resistant to one or more antibiotics, the ciprofloxacin MIC at which 90% of the isolates were inhibited (MIC(90)) was 4 microg/ml, whereas the MIC(90)s of trovafloxacin, grepafloxacin, and gatifloxacin were 0.25 microg/ml.
authors.affiliation: Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, University of Toronto, Toronto, Ontario, Canada. jdeazavedo@mtsinai.on.ca
authors.forename: J C
authors.initials: JC
authors.lastname: de Azavedo
authors.forename: L
authors.initials: L
authors.lastname: Trpeski
authors.forename: S
authors.initials: S
authors.lastname: Pong-Porter
authors.forename: S
authors.initials: S
authors.lastname: Matsumura
authors.forename: D E
authors.initials: DE
authors.lastname: Low
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002170:Canada; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D013291:Streptococcus / Q000145:classification* / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones