title: Symptom dimensions in old-age schizophrenics. Relationship to neuropsychological and motor abnormalities.
abstract: In most factor analytical studies of schizophrenic symptomatology, a three-factor solution was found. The aim of this study was to investigate symptomatological dimensions in old age and to clarify whether the dimensions correlate differently with neuropsychological and motor parameters. One hundred and thirty-one DSM-III-R chronic schizophrenics (mean age 68 years) were assessed using SANS, SAPS, a neuropsychological test battery and motor scales. Exploratory and confirmatory factor analyses yielded a model with three dimensions (negative, disorganized, paranoid), two of which (negative, disorganized) showed different correlations with neuropsychological and motor phenomena. Thus, three symptomatological dimensions could also be demonstrated in a chronic, old-age schizophrenic sample. The pathophysiological significance of the different correlations with neuropsychological and motor parameters should be clarified in neuroimaging and neuropathological studies.
authors.affiliation: Department of Psychiatry, University of Jena, Germany. sauer@landgraf.med-uni.jena.de
authors.forename: H
authors.initials: H
authors.lastname: Sauer
authors.forename: C
authors.initials: C
authors.lastname: Hornstein
authors.forename: P
authors.initials: P
authors.lastname: Richter
authors.forename: A
authors.initials: A
authors.lastname: Mortimer
authors.forename: S R
authors.initials: SR
authors.lastname: Hirsch
mesh_terms: D000367:Age Factors; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000209:etiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents