Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons.
Action potentials elicited in the axon actively back-propagate into the dendritic tree. During this process their amplitudes can be modulated by internal and external factors. We used a compartmental model of a hippocampal CA1 pyramidal neuron to illustrate how this modulation could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation. The simulations suggest that the time relationship between pre- and postsynaptic activity could help regulate the amplitude of back-propagating action potentials, especially in the distal portion of the dendritic tree.
Migliore
M
M
National Research Council, Institute of Advanced Diagnostic Methodologies, Palermo, Italy. migliore@iaif.pa.cnr.it
Hoffman
D A
DA
Magee
J C
JC
Johnston
D
D
D000200:Action Potentials / Q000502:physiology*; D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D004553:Electric Conductivity; D006624:Hippocampus / Q000166:cytology; D008959:Models, Neurological; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000502:physiology*; D017966:Pyramidal Cells / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D011930:Reaction Time / Q000502:physiology; D013569:Synapses / Q000502:physiology
D015221:Potassium Channels; D011188:Potassium