Inhibition of Escherichia coli-induced meningitis by carboxyfullerence.
The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose-dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1beta production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli-induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.
Tsao
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Department of Microbiology & Immunology, College of Medicine, National Cheng Kung University, Tainan, Taipei, Taiwan.
Kanakamma
P P
PP
Luh
T Y
TY
Chou
C K
CK
Lei
H Y
HY
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000473:pathology; D002244:Carbon / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D037741:Fullerenes; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000096:biosynthesis; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000998:Antiviral Agents; D037741:Fullerenes; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D002244:Carbon; C069837:fullerene C60