title: Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey.
abstract: The purpose of the present review is to describe, with particular emphasis on the rhesus monkey, the ontogeny and functional organisation of the hypothalamic GnRH pulse generator. Control of pituitary-gonadal axis in higher primates is provided by a group of some 1,000 GnRH neurons that are diffusely distributed throughout the hypothalamus. After synthesis of a prehormone and formation of the mature decapeptide, GnRH is released in the hypophysial portal circulation and stimulates FSH and LH production.
authors.affiliation: Department of Cell Biology and Physiology, University of Pittsburgh School of Medecine, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Plant
authors.forename: M
authors.initials: M
authors.lastname: el Majdoubi
authors.forename: A R
authors.initials: AR
authors.lastname: Durrant
authors.forename: A
authors.initials: A
authors.lastname: Sahu
mesh_terms: D000375:Aging; D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006066:Gonads / Q000502:physiology*; D007031:Hypothalamus / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D008253:Macaca mulatta / Q000196:embryology / Q000254:growth & development*; D010507:Periodicity; D010902:Pituitary Gland / Q000502:physiology*
chemical_list: D007987:Gonadotropin-Releasing Hormone