title: Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role.
abstract: Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a receptor which belongs to the large family of G-protein-coupled receptors (GPCR). Members of this family of receptor proteins are usually glycosylated on extracellular domains. In recent years the role of this glycosylation in cell surface expression/protein folding, ligand recognition and receptor-effector coupling has been investigated. This review summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), oxytocin (OT) and vasopressin (AVP).
authors.affiliation: School of Biochemistry, University of Birmingham, UK.
authors.forename: M
authors.initials: M
authors.lastname: Wheatley
authors.forename: S R
authors.initials: SR
authors.lastname: Hawtin
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000737:chemistry* / Q000502:physiology*; D006031:Glycosylation; D006801:Humans; D016297:Mutagenesis, Site-Directed; D017510:Protein Folding; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins