Smokers and haemodynamic responses to desflurane.
Changes in basic haemodynamic variables following a sudden increase in the concentration of inspired desflurane administered during anaesthesia were compared in 30 female smokers and 30 nonsmokers. Smokers had significantly greater percentage increases in heart rate (p = 0.02), systolic and diastolic blood pressure (p < 0.005 and = 0.01, respectively) and rate-pressure product (p < 0.005). Such increases were reached faster by smokers for both systolic and diastolic blood pressures (p < 0.01) and for rate-pressure product (p = 0.02). The peak values of rate pressure product reached were sufficient to warrant caution when using desflurane for anaesthesia in smokers.
Fitz-Henry
J
J
Nottingham City Hospital, Nottingham NG5 1PB, UK.
Curran
J
J
Griffiths
D
D
D000328:Adult; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D000077335:Desflurane; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000494:pharmacology; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D012907:Smoking / Q000503:physiopathology*
D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane