[Humoral immune response against A60 antigen from tuberculosis expectoration and the clinical and radiologic state of patients with with pulmonary tuberculosis].
Serological tests available for diagnosis of tuberculosis can provide the valuable informations about host immune response to the mycobacterial infection. The aim of our study was to assess the correlation between clinical, radiological and bacteriological state of pulmonary tuberculosis patients and the serum concentration of IgG antibodies against A60 antigen of Mycobacterium bovis BCG. 110 active pulmonary tuberculosis patients--56 culture positive and 54 culture negative--were involved into the study. In all patients serum level of IgG ati-A60 antibodies was measured with the use of A60-ELISA test. We found that bacteriologically confirmed pulmonary tuberculosis is associated with higher serum level of anti-A60 antibodies. Our study also showed the significantly higher levels of anti-A60 IgG in patients with cavitary and more progressive forms of this disease. We conclude that the greater antigenic challenge in progressive forms of pulmonary tuberculosis stimulates more expressed antibody response.
Siemińska
A
A
Katedry i Kliniki Chorób Płuc i Gruźlicy AM w Gdańsku.
Wolska-Goszka
L
L
Słomiński
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005122:Exudates and Transudates / Q000382:microbiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology* / Q000382:microbiology
D000942:Antigens, Bacterial; D007074:Immunoglobulin G; C055539:mycobacterial A60 antigen