Imidazothiadiazine dioxides: synthesis and antiviral activity.
A new series of imidazothiadiazine dioxides, including the first acyclonucleosides derived from this heterocycle moiety, has been synthesized. A wide-spectrum antiviral screening was performed. Some of the N-1 benzyl imidazothiadiazines and the new acyclonucleosides showed interesting anti-CMV or anti-HIV activity. These structures could be considered as new lead compounds for antiviral drug research.
Martínez
A
A
Instituto de Química Médica (CSIC), Madrid, Spain.
Esteban
A I
AI
Herrero
A
A
Ochoa
C
C
Andrei
G
G
Snoeck
R
R
Balzarini
J
J
De Clercq
E
E
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D013829:Thiadiazines