title: Formation of triple helices at irregular poly (R.Y) sites located in critical positions in the human bcr promoter.
abstract: Two polypurine sequences interrupted respectively by one and two adjacent pyrimidines have been identified in the promoter of the human bcr gene. Although these targets are irregular they are recognised and tightly bound by AG and GT motif triplex-forming oligonucleotides. Thermodynamic and kinetic data are presented.
authors.affiliation: Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine.
authors.forename: L E
authors.initials: LE
authors.lastname: Xodo
authors.forename: E
authors.initials: E
authors.lastname: Del Terra
authors.forename: B
authors.initials: B
authors.lastname: Scaggiante
authors.forename: G
authors.initials: G
authors.lastname: Manzini
authors.forename: F
authors.initials: F
authors.lastname: Quadrifoglio
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics*; D006801:Humans; D007700:Kinetics; D009690:Nucleic Acid Conformation; D015513:Oncogene Proteins / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D051562:Proto-Oncogene Proteins c-bcr; D013816:Thermodynamics
chemical_list: D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D004247:DNA; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr