title: Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.
abstract: Four patients with cystic fibrosis (CF) were examined with combined hyperpolarized helium 3-enhanced and conventional proton magnetic resonance (MR) imaging. After inhalation of the polarized 3He gas, single breath-hold, gradient-echo images (resonant frequency of 3He) were obtained to depict lung ventilation. Conventional T2-weighted fast spin-echo (hydrogen) images were also obtained to depict morphologic abnormalities. 3He images were successfully and reproducibly generated that showed both morphologic abnormalities and, often more extensive, ventilation abnormalities. 3He MR imaging may provide a method for evaluating progression of pulmonary disease in patients with CF.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: L F
authors.initials: LF
authors.lastname: Donnelly
authors.forename: J R
authors.initials: JR
authors.lastname: MacFall
authors.forename: H P
authors.initials: HP
authors.lastname: McAdams
authors.forename: J M
authors.initials: JM
authors.lastname: Majure
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: D P
authors.initials: DP
authors.lastname: Frush
authors.forename: P
authors.initials: P
authors.lastname: Bogonad
authors.forename: H C
authors.initials: HC
authors.lastname: Charles
authors.forename: C E
authors.initials: CE
authors.lastname: Ravin
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D006371:Helium; D006801:Humans; D007089:Image Enhancement; D007554:Isotopes; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results
chemical_list: D007554:Isotopes; D006371:Helium