CYP2D6 and GSTM1 genotypes in a Polish population.
OBJECTIVE
The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population.


METHODS
One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6*3 and CYP2D6*4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative).


RESULTS
Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6*4 and CYP2D6*3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%.


CONCLUSIONS
The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations.
Gawronska-Szklarz
B
B
Department of Pharmacology and Toxicology, Medical University, Szczecin, Poland. gszklarz@r1.pam.szczecin.pl
Wójcicki
M
M
Kuprianowicz
A
A
Kedzierska
K
K
Kedzierski
M
M
Górnik
W
W
Pawlik
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D019389:Cytochrome P-450 CYP2D6 / Q000145:classification / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005982:Glutathione Transferase / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D019389:Cytochrome P-450 CYP2D6; D005982:Glutathione Transferase