Castleman disease presenting with ophthalmic signs and symptoms.
OBJECTIVE
To describe a patient with multicentric Castleman disease who was initially examined with ophthalmic signs and symptoms.


METHODS
Case report. A 71-year-old man was initially examined with swelling of both upper eyelids and diplopia of 2 months' duration.


RESULTS
Medical evaluation and right axillary lymph node biopsy disclosed Castleman disease. Systemic corticosteroid treatment temporarily resolved signs and symptoms, but the patient died of recurrence with cytomegalovirus and Aspergillus infection 10 months after initial examination.


CONCLUSIONS
Multicentric Castleman disease is a rare but distinct disorder that may present initially with ocular signs and symptoms. This disease must be included in the differential diagnosis of orbital pseudotumor and lymphoma.
Kurokawa
T
T
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
Suzuki
S
S
Kawaguchi
K
K
Fujisawa
N
N
Yoshimura
N
N
D000368:Aged; D001228:Aspergillosis / Q000150:complications; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000150:complications; D004172:Diplopia / Q000175:diagnosis* / Q000188:drug therapy; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000188:drug therapy; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity
D005938:Glucocorticoids; C009935:prednisolone acetate; D011239:Prednisolone