title: Modulation of enteric cholinergic neurons by hetero- and autoreceptors: cooperation among inhibitory inputs.
abstract: In the guinea-pig colon, acetylcholine (ACh) release from intrinsic cholinergic motor neurons is inhibited by adrenoceptors, opioid and muscarinic receptors. Chronic sympathetic denervation resulted in supersensitivity to the inhibitory effect of DAMGO (mu-opioid agonist) on ACh release and on the peristaltic reflex. After chronic treatment with naltrexone (NTX) supersensitivity to DAMGO and subsensitivity to UK14,304 (alpha2-adrenoceptor agonist) developed for both functional parameters. The facilitatory effect of scopolamine on ACh release remained unchanged after chronic NTX treatment, whereas it was potentiated after chronic sympathetic denervation. These data suggest the existence of a functional interaction between different inhibitory pathways modulating cholinergic motor neurons in the guinea-pig colon. Namely, chronic manipulation of an inhibitory pathway may entail adaptive sensitivity changes in another inhibitory pathway so that homeostasis can be maintained.
authors.affiliation: Department of Internal Medicine and Therapeutics, University of Pavia, Varese VA, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Giaroni
authors.forename: L
authors.initials: L
authors.lastname: Somaini
authors.forename: F
authors.initials: F
authors.lastname: Marino
authors.forename: M
authors.initials: M
authors.lastname: Cosentino
authors.forename: A
authors.initials: A
authors.lastname: Senaldi
authors.forename: F
authors.initials: F
authors.lastname: De Ponti
authors.forename: S
authors.initials: S
authors.lastname: Lecchini
authors.forename: G
authors.initials: G
authors.lastname: Frigo
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D000068438:Brimonidine Tartrate; D002799:Cholinergic Fibers / Q000502:physiology; D003106:Colon / Q000294:innervation*; D003714:Denervation; D006168:Guinea Pigs; D009046:Motor Neurons / Q000502:physiology; D009271:Naltrexone / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D010528:Peristalsis / Q000502:physiology; D011810:Quinoxalines / Q000494:pharmacology; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology; D011957:Receptors, Opioid / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D000316:Adrenergic alpha-Agonists; D011810:Quinoxalines; D018341:Receptors, Adrenergic, alpha-2; D011957:Receptors, Opioid; D000068438:Brimonidine Tartrate; D009271:Naltrexone; D000109:Acetylcholine; D009638:Norepinephrine