Action of Sosiho-Tang on systemic and local anaphylaxis by anal administration.
The herbal formulation Soshiho-Tang (SS-Tang) has been used against allergic disease for generations, and still occupies an important place in traditional medicine in Korea. Previously, we reported that SS-Tang potently inhibited mast cell- mediated anaphylaxis when orally administered. In this study, we investigated the effect of SS-Tang by anal administration in anaphylaxis responses. SS-Tang dose-dependently inhibited compound 48/80-induced systemic anaphylaxis with doses of 10(-4) to 1 g/kg 1 h before anally administered. Of special note, SS-Tang inhibited systemic anaphylaxis completely with a dose of 1 g/kg. SS-Tang reduced plasma histamine levels induced by compound 48/80 significantly. However, the mortality was 100% when SS-Tang was administered after compound 48/80 treatment. SS-Tang (10(-1) g/kg) also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE antibody by 30.9%. These results provide evidence that anal therapy of SS-Tang may be beneficial in the treatment of systemic and local anaphylaxis.
Kim
H M
HM
College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Kim
Y Y
YY
Jang
H Y
HY
Moon
S J
SJ
An
N H
NH
D000285:Administration, Rectal; D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D006632:Histamine / Q000097:blood; D007723:Korea; D008518:Medicine, East Asian Traditional; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D018926:Anti-Allergic Agents; D000888:Antibodies, Anti-Idiotypic; D010936:Plant Extracts; C026408:anti-IgE antibodies; C580585:soshiho-tang; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine