[Validation of the preparation of individual doses of 51Cr-EDTA in syringes].
The 51Cr-EDTA is one of the radiopharmaceuticals more used in the glomerular filtration rate determination. The necessity to prepare a daily reference dose every time that are prepared the patient's doses can go to a poor exploitation of the multidose vial. One way of improving its use consists on the preparation of individual doses in ready syringes to inject, for several days, employing only one of them as a standard. The aim of this study was to evaluate the storing of 51Cr-EDTA individual doses at room temperature and at 4 degrees C during 4 weeks, analyzing the radiochemical purity, the sterility and the radiopharmaceutical retention into the syringe. The results obtained showed that the radiochemical purity remains stable, always been greater than the value recommended for its use (> 95%). Likewise, there were not microorganism contamination nor 51Cr-EDTA appreciable retention into the syringes. We concluded that the preparation of individual doses of 51Cr-EDTA in syringes and their conservation at room temperature, or at 4 degrees C, during a period of 4 weeks, neither influence in the radiopharmaceutical quality nor increase its retention into the syringe.
Iglesias Allende
F
F
Servicio de Medicina Nuclear, Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona, 08907, España.
Gomes Barreto
V
V
Roca Engroñat
M
M
García Seguí
V
V
Benítez Segura
A
A
Mora Salvadó
J
J
Martín-Comín
J
J
D002860:Chromium Radioisotopes / Q000008:administration & dosage*; D004340:Drug Contamination; D004349:Drug Packaging; D004356:Drug Storage; D004492:Edetic Acid / Q000008:administration & dosage*; D005919:Glomerular Filtration Rate; D006801:Humans; D007267:Injections; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D012015:Reference Standards; D013594:Syringes; D013696:Temperature
D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; D004492:Edetic Acid