Thrombospondin is sequentially expressed and then de-expressed during early pregnancy in the rat uterus.
The expression of thrombospondin on Day 1, Day 3 and Day 6 of pregnancy has been examined in the rat, using light microscopic immunoperoxidase and electron immunogold techniques. The glycoprotein was expressed in the apical, lateral and basal uterine epithelium on Days 1 and 3 but was then de-expressed at the time of implantation on Day 6. We propose that these data suggest a role for thrombospondin in remodellig the uterine epithelium during the plasma membrane transformation, but that it does not play a part in attachment and implantation.
Slater
M
M
Department of Anatomy and Histology F13, The University of Sydney, NSW, Australia.
Murphy
C R
CR
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004847:Epithelial Cells / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D019699:Thrombospondins / Q000096:biosynthesis* / Q000378:metabolism; D014599:Uterus / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure
D019699:Thrombospondins