title: Multichannel cochlear nucleus stimulation.
abstract: Stimulation of the cochlear nucleus (CN) has been used on a limited basis for rehabilitation of a select group of patients with bilateral acoustic neuromas. These patients were implanted with an electrode placed on the surface of the CN after resection of their tumors. Animal studies have demonstrated greater efficiency of a penetrating CN electrode in activating the central auditory system than a surface electrode. The objective of this work was to study the electrically evoked middle latency response generated by stimulation through a penetrating multichannel CN electrode in an animal model. Six pigmented guinea pigs underwent implantation with a penetrating multichannel CN electrode. Threshold, latency, and input-output functions of electrically evoked middle latency responses with different stimulation pads were studied. There were systematic differences in the latency and amplitude of the input-output functions depending on the site of stimulation within the CN. The results support the hypothesis that discrete activation of neuronal subpopulations within the CN is possible with a penetrating multichannel microelectrode.
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor 48109- 0312, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: El-kashlan
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D017626:Cochlear Nucleus / Q000502:physiology*; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D011930:Reaction Time