title: Structure-based design and synthesis of a novel class of Src SH2 inhibitors.
abstract: The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
authors.affiliation: ARIAD Pharmaceuticals, Inc., Cambridge, Massachusetts 02139-4234, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Buchanan
authors.forename: R S
authors.initials: RS
authors.lastname: Bohacek
authors.forename: G P
authors.initials: GP
authors.lastname: Luke
authors.forename: M
authors.initials: M
authors.lastname: Hatada
authors.forename: X
authors.initials: X
authors.lastname: Lu
authors.forename: D C
authors.initials: DC
authors.lastname: Dalgarno
authors.forename: S S
authors.initials: SS
authors.lastname: Narula
authors.forename: R
authors.initials: R
authors.lastname: Yuan
authors.forename: D A
authors.initials: DA
authors.lastname: Holt
mesh_terms: D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D018909:src Homology Domains
chemical_list: D013844:Thiazoles