title: [The local immunity of the urinary system in patients with recurrent urolithiasis].
abstract: 51 patients with urolithiasis complicated by pyelonephritis in the active phase of inflammation were studied for the condition of local immunity by determining the urine content of secretory immunoglobulin A (SIgA) under conditions of combined treatment with making use of phlogenzyme, a drug of II-generation systemic enzymotherapy (SE). Recordable in this patients population was a marked increase in the urine level of SIgA. Incorporation in a combined treatment of phlogenzyme results in normalizing the status of the urinary system local immunity. Evidence has been obtained on the lack of parallelism in the dynamics between the serum IgA content and urine concentration of SIgA, which fact suggests independence of local immunity. Our theory is that an appreciable increase in the urine level of SIgA in patients with urolithiasis concurrent with pyelonephritis may have an important part to play in the genesis of nephrolithiasis.
authors.forename: A V
authors.initials: AV
authors.lastname: Borisov
mesh_terms: D000328:Adult; D000368:Aged; D001963:Bromelains / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007109:Immunity; D007071:Immunoglobulin A, Secretory / Q000652:urine; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000209:etiology / Q000276:immunology / Q000628:therapy; D012008:Recurrence; D012431:Rutin / Q000031:analogs & derivatives / Q000627:therapeutic use; D014357:Trypsin / Q000627:therapeutic use; D014545:Urinary Calculi / Q000150:complications / Q000276:immunology* / Q000628:therapy; D014551:Urinary Tract / Q000276:immunology* / Q000601:surgery
chemical_list: D004338:Drug Combinations; D007071:Immunoglobulin A, Secretory; C119937:Phlogenzym; D012431:Rutin; D001963:Bromelains; D014357:Trypsin