Local delivery of chlorhexidine using a tooth-bonded delivery system.
Films containing 20% w/w chlorhexidine base (particle size 63-125 microm) in poly(epsilon-caprolactone), MW 35,000-45,000, were prepared by solvent evaporation and sections attached to the mesio-lingual and mesio-buccal surfaces of the lower first molar in healthy volunteers. Saliva (<1.5 microl) was collected on Periopaper and chlorhexidine concentrations measured by HPLC were typically higher in the area immediately adjacent to the tooth-bonded film sections and lower at more distant sites. Analysis of variance of chlorhexidine concentrations, adjacent to the film sections, showed concentrations were significantly different on the buccal and lingual sides of the tooth and depended on the time of sampling (n=5, P<0.05).
Medlicott
N J
NJ
School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand. natalie.medlicott@stonebow.otago.ac.nz
Holborow
D W
DW
Rathbone
M J
MJ
Jones
D S
DS
Tucker
I G
IG
D000284:Administration, Oral; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001840:Dental Bonding; D016503:Drug Delivery Systems; D006801:Humans; D009067:Mouthwashes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010316:Particle Size; D011091:Polyesters / Q000008:administration & dosage; D012463:Saliva / Q000378:metabolism
D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D011091:Polyesters; C016240:polycaprolactone; D002710:Chlorhexidine