title: [Rapid pulse injection of indocyanine green angiography for evaluation of choroidal venous circulation].
abstract: OBJECTIVE
  To investigate the influence of the injection duration on the early phase of indocyanine green fundus angiography, we performed indocyanine green fundus angiography using a rapid pulse injection method, and compared early-phase findings with those obtained using a previous injection method.
  
  
  METHODS
  Rabbit eyes were used. Normal eyes (10), eyes with chorioretinal atrophy (5), and eyes with occlusion of vortex veins (5) were examined.
  
  
  RESULTS
  In normal eyes, rapid pulse injection resulted in visualization of some small bright fluorescent boluses from 6 to 12 seconds after injection, whereas with the previous method they were unclear. In eyes with occlusion of vortex veins, rapid pulse injection resulted in visualization of delayed hyperfluorescence of choroidal veins against the background, and the region of delayed venous filling could easily be determined. In eyes with chorioretinal atrophy, only the rapid pulse injection clearly revealed delayed filling of choroidal veins.
  
  
  CONCLUSIONS
  The rapid pulse injection method enabled detection of lesions which were not clearly visible using the previous injection method, and is useful for study of choroidal circulation.
authors.affiliation: Department of Ophthalmology, Osaka City University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kano
mesh_terms: D000818:Animals; D002829:Choroid / Q000098:blood supply*; D005451:Fluorescein Angiography / Q000379:methods*; D007208:Indocyanine Green / Q000008:administration & dosage*; D007267:Injections; D011817:Rabbits; D014680:Veins / Q000502:physiology
chemical_list: D007208:Indocyanine Green