Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear.
The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression of Serrate1 (Jagged1), meanwhile becomes restricted to the supporting cells of each sensory patch. Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1.
Morrison
A
A
Imperial Cancer Research Fund, London, UK.
Hodgetts
C
C
Gossler
A
A
Hrabé de Angelis
M
M
Lewis
J
J
D000818:Animals; D002135:Calcium-Binding Proteins; D003051:Cochlea / Q000196:embryology / Q000378:metabolism; D007758:Ear, Inner / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D000072099:Serrate-Jagged Proteins; D001616:beta-Galactosidase / Q000235:genetics
D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; C000606274:Jag1 protein, mouse; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D011506:Proteins; D000072099:Serrate-Jagged Proteins; C064045:delta protein; D001616:beta-Galactosidase