Effects of reducing submandibular blood flow on secretory responses to parasympathetic stimulation in anaesthetized cats.
Submandibular secretory responses to stimulation of the parasympathetic chorda-lingual nerve were investigated in five anaesthetized cats before, during and after withdrawal of blood (ca 20 ml kg-1) in order to investigate the consequences of a reduced blood flow through the gland. Stimulation at different frequencies (2, 4, 6 and 8 Hz) evoked a frequency-dependent increase in the flow of submandibular saliva, sodium concentration, electrolyte and protein output. When the blood pressure was reduced (by about 50%) there was a significant reduction in submandibular blood flow and the secretion of both saliva and protein during stimulation. Under each set of conditions the flow of saliva was linearly related to the blood flow through the gland. It is concluded that submandibular secretory responses to electrical stimulation of the parasympathetic innervation can be significantly attenuated when the blood flow through the gland is reduced under the conditions employed in this study.
Hanna
S J
SJ
Physiological Laboratory, University of Cambridge, UK.
Brelen
M E
ME
Edwards
A V
AV
D000768:Anesthesia, General; D000818:Animals; D001794:Blood Pressure; D002415:Cats; D003714:Denervation; D004558:Electric Stimulation; D008036:Lingual Nerve / Q000502:physiology / Q000601:surgery; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010477:Perfusion; D012039:Regional Blood Flow / Q000502:physiology; D012463:Saliva / Q000378:metabolism*; D012472:Salivation / Q000502:physiology*; D013363:Submandibular Gland / Q000098:blood supply* / Q000294:innervation / Q000378:metabolism