Restoration of ocular dominance plasticity mediated by adenosine 3',5'-monophosphate in adult visual cortex.
Noradrenaline (NA)-stimulated beta-adrenoreceptors activate adenylate cyclase via excitatory G-proteins (Gs). Activated adenylate cyclase in turn promotes the production of cAMP. Critical roles of cAMP-dependent protein kinase A (PKA) in divergent cellular functions have been shown, including memory, learning and neural plasticity. Ocular dominance plasticity (ODP) is strongly expressed in early postnatal life and usually absent in the mature visual cortex. Here, we asked whether the activation of cAMP-dependent PKA could restore ODP to the aplastic visual cortex of adult cats. Concurrent with brief monocular deprivation, each of the following cAMP-related drugs was directly and continuously infused in the adult visual cortex: cholera toxin (a Gs-protein stimulant), forskolin (a Gs-protein-independent activator of adenylate cyclase) and dibutyryl cAMP (a cAMP analogue). We found that the ocular dominance distribution became W-shaped, the proportion of binocular cells being significantly lower than that in respective controls. We concluded that the activation of cAMP cascades rapidly restores ODP to the adult visual cortex, though moderately. The finding further extends the original hypothesis that the NA-beta-adrenoreceptors system is a neurochemical mechanism of cortical plasticity.
Imamura
K
K
Subfemtomole Biorecognition Project, Japan Science and Technology Corporation, Osaka, Japan.
Kasamatsu
T
T
Shirokawa
T
T
Ohashi
T
T
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002415:Cats; D002772:Cholera Toxin / Q000633:toxicity; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D015290:Second Messenger Systems; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D005576:Colforsin; D003994:Bucladesine; D002772:Cholera Toxin; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D009638:Norepinephrine