Rational herbicide design by inhibition of tryptophan biosynthesis.
Compounds designed to mimic the tryptophan synthase alpha subunit reactive intermediate were found to be potent inhibitors of the enzyme. These compounds are herbicidal and the herbicidal mode of action was demonstrated to be due to disruption of tryptophan biosynthesis.
Finn
J
J
American Cyanamid, Agricultural Research, Princeton, NJ 08540, USA.
Langevine
C
C
Birk
I
I
Birk
J
J
Nickerson
K
K
Rodaway
S
S
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D014364:Tryptophan / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D014367:Tryptophan Synthase / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D006540:Herbicides; D014364:Tryptophan; D014367:Tryptophan Synthase