Xenotransplantability of human squamous cell lung cancer in nude mice is not affected by angiogenic factors.
Sixty-two human squamous cell lung carcinomas were analyzed for expression of various angiogenic growth factors and their receptors using immunohistochemistry. The data were correlated with xenotransplantability of these tumors in nude mice. None of the factors investigated did show an association with xenotransplantability. However, there was a trend that specimens lacking VEGF165 were established as xenografts at a higher incidence (52%) than those expressing VEGF165 (39%).
Mattern
J
J
Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany. j.mattern@dkfz-heidelberg.de
Koomägi
R
R
Volm
M
M
D000328:Adult; D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000032:analysis / Q000502:physiology*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis; D006085:Graft Survival; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008222:Lymphokines / Q000032:analysis / Q000502:physiology*; D008297:Male; D051379:Mice; D008819:Mice, Nude / Q000502:physiology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000502:physiology*; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D020794:Receptor Protein-Tyrosine Kinases / Q000032:analysis; D017468:Receptors, Fibroblast Growth Factor / Q000032:analysis; D017978:Receptors, Growth Factor / Q000032:analysis; D040262:Receptors, Vascular Endothelial Growth Factor; D013045:Species Specificity; D013939:Thymidine Phosphorylase / Q000032:analysis; D014183:Transplantation, Heterologous; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D009363:Neoplasm Proteins; D010982:Platelet-Derived Growth Factor; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2; D013939:Thymidine Phosphorylase; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor