title: [The evolution of the clinical course of infectious endocarditis].
abstract: As many as 188 records of IE patients were studied as were 67 autopsies of deceased persons. Significant changes in the clinical course of IE were disclosed over the past 10-15 years versus previous 15: more prominent role of staphylococcal and gram-negative flora in the etiology of the illness, with microbial associations-caused IE cases having become more common. Diagnostic value of hemoculture did not appear to show much promise. The following items were found to be important risk factors for IE: prior viral and bacterial infection, invasive interventions, and chronic somatic diseases. There prevailed those IE forms having appeared on the intact heart valves in elderly persons and those at a mature age. In the course of the illness there tended to be more toxic and allergic manifestations, thromboembolic complications, and extensive vascular pathology.
authors.forename: I K
authors.initials: IK
authors.lastname: Asauliuk
authors.forename: M P
authors.initials: MP
authors.lastname: Boĭchak
authors.forename: S I
authors.initials: SI
authors.lastname: Zagorodniĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000150:complications / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D013923:Thromboembolism / Q000209:etiology / Q000473:pathology