title: Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C.
abstract: Epidemiological and experimental data suggest that the hepatitis C virus infection might be associated with the development of distinct types of non-Hodgkin's lymphomas. Here, we report a case of a patient with chronic hepatitis C and type II mixed cryoglobulinemia, who developed a primary hepatic non-Hodgkin's B-cell lymphoma. A diffuse, large B-cell lymphoma was diagnosed based on morphological, immunophenotypical and molecular genetic findings. Hepatitis C virus replication, as evaluated by strand-specific reverse transcriptase-polymerase chain reaction, was detected in the nonneoplastic liver, but not in the lymphomatous tissue. High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions.
authors.affiliation: Division of Clinical Pathology, University Hospital, Geneva, Switzerland. rubbia@dim.hcuge.ch
authors.forename: L
authors.initials: L
authors.lastname: Rubbia-Brandt
authors.forename: M A
authors.initials: MA
authors.lastname: Bründler
authors.forename: K
authors.initials: K
authors.lastname: Kerl
authors.forename: F
authors.initials: F
authors.lastname: Negro
authors.forename: R G
authors.initials: RG
authors.lastname: Nador
authors.forename: A
authors.initials: A
authors.lastname: Scherrer
authors.forename: A M
authors.initials: AM
authors.lastname: Kurt
authors.forename: G
authors.initials: G
authors.lastname: Mentha
authors.forename: B
authors.initials: B
authors.lastname: Borisch
mesh_terms: D003449:Cryoglobulinemia / Q000209:etiology; D016174:Hepacivirus / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011859:Radiography