title: Consequences of acute normovolaemic haemodilution on haemostasis during major orthopaedic surgery.
abstract: Acute preoperative normovolaemic haemodilution (NHD) is an accepted tool for reducing allogeneic blood transfusion requirements during surgery. At present, little is known of its impact on haemostasis. We have investigated the consequences of NHD on haemostasis by comparing conventional global tests (prothrombin time (PT), activated partial thromboplastin time (aPTT) with more specific measures of coagulation (prothrombin fragment 1 + 2 (F 1 + 2), thrombin-antithrombin III complex (TAT) and fibrinolysis (D-dimer (DD), plasmin-alpha 2-antiplasmin complex (PAP)). Blood samples were collected from two groups (NHD and controls) undergoing elective spinal surgery or pelvic osteotomy until day 3 after operation. The conventional global tests remained within normal limits: there were no significant differences between groups. Although surgery induced significant increases in the more specific measures of coagulation and fibrinolysis, there were no differences between NHD and control patients. Major orthopaedic surgery strongly activates coagulation and fibrinolysis. As the degree of these alterations was similar in haemodiluted and control patients, we suggest that acute preoperative normovolaemic haemodilution itself does not appear to be associated with greater perioperative disturbances in haemostasis.
authors.affiliation: Clinic for Anaesthesia and General Intensive Care Medicine, University of Innsbruck, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Hobisch-Hagen
authors.forename: B
authors.initials: B
authors.lastname: Wirleitner
authors.forename: J
authors.initials: J
authors.lastname: Mair
authors.forename: G
authors.initials: G
authors.lastname: Luz
authors.forename: P
authors.initials: P
authors.lastname: Innerhofer
authors.forename: B
authors.initials: B
authors.lastname: Frischhut
authors.forename: H
authors.initials: H
authors.lastname: Ulmer
authors.forename: W
authors.initials: W
authors.lastname: Schobersberger
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D006438:Hemodilution; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011184:Postoperative Period; D011300:Preoperative Care / Q000379:methods*
chemical_list: D015415:Biomarkers