title: Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer.
abstract: In a population-based case-control study of pancreatic cancer conducted in three areas of the USA, 484 cases and 2099 controls were interviewed to evaluate the aetiologic role of several medical conditions/interventions, including diabetes mellitus, cholecystectomy, ulcer/gastrectomy and allergic states. We also evaluated risk associated with family history of cancer. Our findings support previous studies indicating that diabetes is a risk factor for pancreatic cancer, as well as a possible complication of the tumour. A significant positive trend in risk with increasing years prior to diagnosis of pancreatic cancer was apparent (P-value for test of trend = 0.016), with diabetics diagnosed at least 10 years prior to diagnosis having a significant 50% increased risk. Those treated with insulin had risks similar to those not treated with insulin (odds ratio (OR) = 1.6 and 1.5 respectively), and no trend in risk was associated with increasing duration of insulin treatment. Cholecystectomy also appeared to be a risk factor, as well as a consequence of the malignancy. Subjects with a cholecystectomy at least 20 years prior to the diagnosis of pancreatic cancer experienced a 70% increased risk, which was marginally significant. In contrast, subjects with a history of duodenal or gastric ulcer had little or no elevated risk (OR = 1.2; confidence interval = 0.9-1.6). Those treated by gastrectomy had the same risk as those not receiving surgery, providing little support for the hypothesis that gastrectomy is a risk factor for pancreatic cancer. A significant 40% reduced risk was associated with hay fever, a non-significant 50% decreased risk with allergies to animals, and a non-significant 40% reduced risk with allergies to dust/moulds. These associations, however, may be due to chance since no risk reductions were apparent for asthma or several other types of allergies. In addition, we observed significantly increased risks for subjects reporting a first-degree relative with cancers of the pancreas (OR = 3.2), colon (OR = 1.7) or ovary (OR = 5.3) and non-significantly increased risks for cancers of the endometrium (OR = 1.5) or breast (OR = 1.3). The pattern is consistent with the familial predisposition reported for pancreatic cancer and with the array of tumours associated with hereditary non-polyposis colon cancer.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Silverman
authors.forename: M
authors.initials: M
authors.lastname: Schiffman
authors.forename: J
authors.initials: J
authors.lastname: Everhart
authors.forename: A
authors.initials: A
authors.lastname: Goldstein
authors.forename: K D
authors.initials: KD
authors.lastname: Lillemoe
authors.forename: G M
authors.initials: GM
authors.lastname: Swanson
authors.forename: A G
authors.initials: AG
authors.lastname: Schwartz
authors.forename: L M
authors.initials: LM
authors.lastname: Brown
authors.forename: R S
authors.initials: RS
authors.lastname: Greenberg
authors.forename: J B
authors.initials: JB
authors.lastname: Schoenberg
authors.forename: L M
authors.initials: LM
authors.lastname: Pottern
authors.forename: R N
authors.initials: RN
authors.lastname: Hoover
authors.forename: J F
authors.initials: JF
authors.lastname: Fraumeni
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002763:Cholecystectomy / Q000706:statistics & numerical data; D016001:Confidence Intervals; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D005743:Gastrectomy / Q000706:statistics & numerical data; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D009679:Nuclear Family; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D012016:Reference Values; D012042:Registries; D012307:Risk Factors; D012907:Smoking; D013276:Stomach Ulcer / Q000453:epidemiology; D014481:United States / Q000453:epidemiology