[Xenotransplantation. Possibilities of animal breeding].
The pig is the most likely donor organism for xenotransplantation of organs to humans. However, since this constellation is discordant, hyperacute rejection needs to be overcome. This review summarises current strategies of genetically modifying pigs for xenotransplantation. Limitations of the classical method of DNA-microinjection and new perspectives arising from the possibility of cloning animals from cultured cells are discussed.
Wolf
E
E
Lehrstuhl für Molekulare Tierzucht und Haustiergenetik-Genzentrum, Ludwig-Maximilians-Universität München.
Schernthaner
W
W
Müller
S
S
Brem
G
G
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D001947:Breeding; D019976:Cloning, Organism; D018014:Gene Transfer Techniques; D006801:Humans; D013552:Swine / Q000235:genetics*; D014183:Transplantation, Heterologous