Transmission of factor VII deficiency through liver transplantation.
The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.
Guy
S R
SR
The Recanati/Miller Transplantation Institute, Mount Sinai Medical Center, Box 1104, One Gustave L. Levy Place, New York, New York 10029-6574, USA.
Magliocca
J F
JF
Fruchtman
S
S
McDonough
P
P
Emre
S
S
Kim-Schluger
L
L
Sheiner
P A
PA
Fishbein
T M
TM
Schwartz
M E
ME
Miller
C M
CM
D000328:Adult; D005168:Factor VII Deficiency / Q000175:diagnosis; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011517:Prothrombin Time; D014019:Tissue Donors