title: Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report.
abstract: The transmission of a deleted in azoospermia (DAZ) deletion from a severely oligozoospermic patient to his son following intracytoplasmic sperm injection (ICSI) treatment is reported. The case report highlights the fertilizing capacity of spermatozoa carrying Y chromosome deletions in patients treated with ICSI and stresses the importance of genetic counselling in severe male infertility.
authors.affiliation: Institute of Reproductive Medicine and Department of Obstetrics and Gynaecology of the University, Domagkstr. 11, D-48129 Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kamischke
authors.forename: J
authors.initials: J
authors.lastname: Gromoll
authors.forename: M
authors.initials: M
authors.lastname: Simoni
authors.forename: H M
authors.initials: HM
authors.lastname: Behre
authors.forename: E
authors.initials: E
authors.lastname: Nieschlag
mesh_terms: D000328:Adult; D000075364:Deleted in Azoospermia 1 Protein; D005307:Fertilization in Vitro / Q000379:methods*; D017353:Gene Deletion; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D008845:Microinjections; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014998:Y Chromosome
chemical_list: C118459:CDY1 protein, human; C485564:CDY2A protein, human; C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D009687:Nuclear Proteins; D011506:Proteins; D016601:RNA-Binding Proteins