title: 2-5A-PNA complexes: a novel class of antisense compounds.
abstract: This paper presents the fully automated solid phase synthesis of 2-5A-PNA hybrids. These stable antisense probes cause RNase L mediated hydrolysis of target RNA sequences.
authors.affiliation: Leiden Institute of Chemistry, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Verheijen
authors.forename: S F
authors.initials: SF
authors.lastname: Bayly
authors.forename: M R
authors.initials: MR
authors.lastname: Player
authors.forename: P F
authors.initials: PF
authors.lastname: Torrence
authors.forename: G A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
mesh_terms: D001483:Base Sequence; D004722:Endoribonucleases / Q000737:chemistry; D006868:Hydrolysis; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D016376:Oligonucleotides, Antisense; D020135:Peptide Nucleic Acids; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease