Thermodynamic studies on hairpin forming antisense-oligodeoxynucleotides directed against hepatitis C virus RNA.
Phosphorothioate and benzyl-modified antisense-oligodeoxynucleotides directed against nucleotides 334-350 of the Hepatitis C Virus RNA form surprisingly stable hairpins. These data contribute to solve a structural detail information in search for a global secondary structure model of the Non Coding Region (NCR) of HCV.
Lehmann
T J
TJ
Institute of Organic Chemistry, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
Eisenhardt
S
S
Engels
J W
JW
D001483:Base Sequence; D016174:Hepacivirus / Q000235:genetics*; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000494:pharmacology; D012367:RNA, Viral / Q000235:genetics*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D016376:Oligonucleotides, Antisense; D012367:RNA, Viral