[The control leprous peripheral neuropathy and chemotherapy].
Clarithromycin(CAM), Roxithromycin(RXM), Minocycline(MINO) and Fosfomycin(FOM) has anti-inflammatory action and immunomodulatory activity, while the anti-mycobacterium leprae activity is shown. CAM and RXM suppress the rat carrageenin edema, and MINO suppresses the rat adjvant arthritis. There is the immunosuppression on adrenocorticosteroid while the inflammatory cytokine is suppressed. CAM, MINO, FOM suppresses the inflammatory cytokine, while it has the immunomodulatory activity. Fusidic acid(FA) suppresses the inflammatory cytokine with the action of being similar to cyclosporin A, and it has the immunomodulatory activity. New macrolides derivatives, CAM and RXM showed the inflammatory regulation, and MINO showed the anti-inflammatory activity with FA. The combination chemotherapy can be enforced, while peripheral neuropathy is prevented by the control of the leprosy reaction.
Gidoh
M
M
Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan. m-gidoh@nih.go.jp
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005578:Fosfomycin / Q000008:administration & dosage; D005672:Fusidic Acid / Q000008:administration & dosage; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage*; D007918:Leprosy / Q000150:complications / Q000188:drug therapy*; D008911:Minocycline / Q000008:administration & dosage; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage; D051381:Rats; D015575:Roxithromycin / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D007917:Leprostatic Agents; D011500:Protein Synthesis Inhibitors; D015575:Roxithromycin; D005578:Fosfomycin; D005672:Fusidic Acid; D008911:Minocycline; D017291:Clarithromycin