[The effect of the ultraviolet irradiation of the blood and of hemosorption on the biochemical signs of endogenous intoxication in asthma patients].
Effects were studied of ultraviolet irradiation of blood and of hemosorption on nonspecific signs of inflammation and endotoxic syndrome such as serum level of medium-weight molecules and percentage of their hydrophobic portion, the content of sialic acids and seromucoid, the binding capacity of blood proteins, and extent of conformational alterations in albumin. It has been ascertained that medium-molecular weight substances are a factor in the pathogenesis of endotoxic syndrome in patients with bronchial asthma, which fact is a reflection of exacerbation of the illness. It is suggested that medium-molecular weight substances might have a part in the decline of the blood protein transport function and in progressing of the conformational alterations in the principal transport protein albumin. Hemosorption and ultraviolet irradiation of blood make for alleviation of endotoxic syndrome and offer advantage of shortening the time the remission supervenes in. The above techniques have direct antiinflammatory and detoxicating effects.
Tkachenko
Iu Ia
IuIa
D000208:Acute Disease; D000328:Adult; D001249:Asthma / Q000097:blood / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D001769:Blood / Q000528:radiation effects*; D003131:Combined Modality Therapy; D006464:Hemoperfusion; D006801:Humans; D008970:Molecular Weight; D010455:Peptides / Q000097:blood; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000628:therapy*; D014467:Ultraviolet Therapy
D015415:Biomarkers; D010455:Peptides