title: Etiopathogenesis of acute pancreatitis.
abstract: Acute pancreatitis is a disease that has many causes. Each cause seems to affect the acinar cell in some way that results in the premature activation and retention of potent proteolytic enzymes. These activated enzymes then injure the acinar cell and cause the immediate release of cytokines and activate the complement system. Together, these molecules attract and sequester inflammatory cells, in particular neutrophils, which causes further secretion of cytokines, free radicals, and other vasoactive molecules, such as nitric oxide. We propose that the released inflammatory molecules induce local effects, such as pancreatic edema and necrosis, and systemic complications, such as hypotension, tachycardia, fever, capillary leak syndrome, and hypoxia. The cytokines released in the pancreas also stimulate apoptosis, further enhancing the cell death response in pancreatitis. Much of the current research is aimed at understanding the links between these series of events and finding agents that can modulate the cascade of events involved in pancreatitis. What is promising in this endeavor is that the response produced with pancreatitis is nearly identical with all etiologies, suggesting that therapy may not have to be specific to a particular cause. The mechanistic models of AP presented herein are supported by preliminary clinical studies that suggest that protease and cytokine inhibitors may improve the course of AP in specific clinical settings.
authors.affiliation: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: S
authors.initials: S
authors.lastname: Karne
authors.forename: F S
authors.initials: FS
authors.lastname: Gorelick
mesh_terms: D000208:Acute Disease; D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D002769:Cholelithiasis / Q000150:complications; D016207:Cytokines / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism; D006801:Humans; D010195:Pancreatitis / Q000201:enzymology / Q000209:etiology* / Q000473:pathology
chemical_list: D016207:Cytokines; D004792:Enzyme Precursors