title: Giant proteases: beyond the proteasome.
abstract: Proteasomes and related proteases are thought to be the principal machinery responsible for intracellular protein degradation. A new class of giant proteases has been discovered that can augment the catabolic functions of proteasomes and, under some conditions, may even substitute for proteasomes altogether.
authors.affiliation: Department of Biochemistry, University of Iowa, Bowen Science Building, 51 Newton Road, Iowa City, Iowa 52242-1109, USA.
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: R E
authors.initials: RE
authors.lastname: Cohen
mesh_terms: D000626:Aminopeptidases; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D010450:Endopeptidases / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D007091:Image Processing, Computer-Assisted; D008854:Microscopy, Electron; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D013822:Thermoplasma / Q000201:enzymology
chemical_list: D009097:Multienzyme Complexes; D010450:Endopeptidases; C102094:tricorn protease; D000626:Aminopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex