[Antibacterial peptides isolated from the urine of healthy adults].
Gel chromatography on Sephadex G-25, DEAE Sephadex A-25 and electrophoresis were used for isolation of two peptides from urine of healthy adults. Isolated peptides exhibited a higher antibacterial activity than antibiotics penicillin and tetracycline. The inhibitory zone of these peptides is similar to that of ampicillin. Chemical analysis of the isolated peptides revealed that one is composed of 5 and the other of 7 amino acids. In both peptides was the concentration of glycine the highest from all amino acids. the highest. (Tab. 1, Fig. 4, Ref. 22.)
Adam
J
J
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Safarikiensis University, Kosice, Slovakia.
Chavkova
Z
Z
Surzin
J
J
Grega
B
B
D000328:Adult; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000652:urine; D002850:Chromatography, Gel; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D010455:Peptides; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010455:Peptides