Chromosome segregation: dual control ensures fidelity.
A mitotic checkpoint arrests cell cycle progression in response to spindle damage. It now appears that this checkpoint has two separate arms, one that prevents anaphase and a second that prevents cytokinesis and DNA re-replication.
Taylor
S S
SS
School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK. stephen.taylor@man.ac.uk
D000705:Anaphase / Q000502:physiology; D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D002455:Cell Division / Q000502:physiology; D002875:Chromosomes / Q000502:physiology*; D015825:Chromosomes, Fungal / Q000502:physiology; D004261:DNA Replication; D005656:Fungal Proteins / Q000502:physiology; D018386:Kinetochores / Q000502:physiology; D064246:Mad2 Proteins; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D009687:Nuclear Proteins; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D008941:Spindle Apparatus / Q000502:physiology
C070351:BUB2 protein, S cerevisiae; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; C577695:MAD2 protein, S cerevisiae; D064246:Mad2 Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins