Fatty acids: links between genes involved in fatty acid and cholesterol metabolism.
Fatty acids are a major constituent of dietary fats and form an integral part of the cellular membrane and lipoproteins. The gene regulatory potential of fatty acids has long been recognized, but the precise regulatory mechanisms are unknown. The regulatory ability of fatty acids on the expression of a number of genes together with potential mechanisms and pathways of regulation are reviewed. In this review, we emphasize a key aspect of regulation mediated by the sterol regulatory element binding-protein, and its effects on sterol regulatory elements.
Worgall
T S
TS
Institute of Human Nutrition, Columbia University, New York, NY, USA.
Deckelbaum
R J
RJ
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D008040:Genetic Linkage; D006801:Humans; D013261:Sterols / Q000378:metabolism; D014158:Transcription, Genetic
D005227:Fatty Acids; D013261:Sterols; D002784:Cholesterol