Analysis of periprosthetic capsular tissue from women with silicone breast implants by magic-angle spinning NMR.
The amount of silicone (polydimethylsiloxane [PDMS]) in capsular tissue surgically removed from women with breast implants was measured by using (29)Si and (1)H magic-angle spinning solid-state NMR spectroscopy. Twelve women having smooth surface silicone gel-filled implants, including a subject with "low-bleed" double-lumen implants, had detectable levels of PDMS ranging from 0. 05 to 9.8% silicon in wet tissue (w/w). No silicon-containing compounds other than PDMS were detected. No correlation was found between the amount of PDMS measured in the capsular tissue and the length of implantation time (Pearson correlation coefficient, r = 0. 22). The results showed no relationship between higher amounts of PDMS and capsular contracture (p = 0.74) or other symptoms (p = 0. 53). Magn Reson Med 42:436-441, 1999.
Garrido
L
L
Biomaterials Laboratory, NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA. garrido@nmr.mgh.harvard.edu
Young
V L
VL
D001940:Breast / Q000737:chemistry*; D018427:Breast Implants; D005260:Female; D006801:Humans; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012828:Silicones / Q000032:analysis*; D018709:Statistics, Nonparametric
D012828:Silicones