title: Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation.
abstract: Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress that may be ameliorated by antioxidants. Our previous study had shown that rats given dietary supplements of fruit and vegetable extracts with high antioxidant activity for 8 months beginning at 6 months of age retarded age-related declines in neuronal and cognitive function. The present study showed that such supplements (strawberry, spinach, or blueberry at 14.8, 9.1, or 18.6 gm of dried aqueous extract per kilogram of diet, respectively) fed for 8 weeks to 19-month-old Fischer 344 rats were also effective in reversing age-related deficits in several neuronal and behavioral parameters including: oxotremorine enhancement of K(+)-evoked release of dopamine from striatal slices, carbachol-stimulated GTPase activity, striatal Ca(45) buffering in striatal synaptosomes, motor behavioral performance on the rod walking and accelerod tasks, and Morris water maze performance. These findings suggest that, in addition to their known beneficial effects on cancer and heart disease, phytochemicals present in antioxidant-rich foods may be beneficial in reversing the course of neuronal and behavioral aging.
authors.affiliation: United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Joseph
authors.forename: B
authors.initials: B
authors.lastname: Shukitt-Hale
authors.forename: N A
authors.initials: NA
authors.lastname: Denisova
authors.forename: D
authors.initials: D
authors.lastname: Bielinski
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: J J
authors.initials: JJ
authors.lastname: McEwen
authors.forename: P C
authors.initials: PC
authors.lastname: Bickford
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D019587:Dietary Supplements; D004298:Dopamine / Q000378:metabolism; D005638:Fruit; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D015398:Signal Transduction / Q000187:drug effects; D018724:Spinacia oleracea; D013574:Synaptosomes / Q000187:drug effects / Q000502:physiology
chemical_list: D010936:Plant Extracts; D005978:Glutathione; D011188:Potassium; D002118:Calcium; D004298:Dopamine