A spatial approach to transcriptional profiling: mechanotransduction and the focal origin of atherosclerosis.
The initiation and progression of focal atherosclerotic lesions has long been known to be associated with regions of disturbed blood flow. Improved precision in experimental models of spatially defined flow has recently been combined with regional and single-cell gene-expression profiling to investigate the relationships linking haemodynamics to vessel-wall pathobiology.
Davies
P F
PF
Institute for Medicine and Engineering, and the Departments of Pathology and Laboratory Medicine, and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. pfd@pobox.upenn.edu
Polacek
D C
DC
Handen
J S
JS
Helmke
B P
BP
DePaola
N
N
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002469:Cell Separation; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D015870:Gene Expression; D006439:Hemodynamics; D006801:Humans; D016372:RNA, Antisense / Q000235:genetics; D012039:Regional Blood Flow; D014158:Transcription, Genetic / Q000235:genetics*
D016372:RNA, Antisense