title: Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse.
abstract: No neurons in the laterodorsal tegmental nucleus (LDTg) show monoamine oxidase (MAO) activity in the rat or monkey. However, in our recent study, many LDTg neurons with MAO type B (MAOB)-activity were found in MAOA-deficient mice that were derived from C3H mouse line. In the present study, LDTg neurons with MAOB-activity were found not only in normal C3H mouse but also in BALB/C and C57BL/6 mouse lines: MAO histochemistry revealed LDTg neurons with MAO-activity even after pharmacological suppression of MAOA-activity with clorgyline, a specific MAOA inhibitor, but not after pharmacological suppression of MAOB-activity with deprenyl, a specific MAOB inhibitor. LDTg neurons with MAOB-activity also showed NADPH-diaphorase-activity, a marker of cholinergic neurons.
authors.affiliation: Department of Anatomy, Fujita Health University, School of Medicine, Aichi, Japan. kikemoto@fujita-hu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ikemoto
authors.forename: K
authors.initials: K
authors.lastname: Kitahama
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Jouvet
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
mesh_terms: D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008995:Monoamine Oxidase / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D013045:Species Specificity; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline