Induction of glomerular lesions in the kidneys of mice infected with vero toxin-producing Escherichia coli by lipopolysaccharide injection.
Lipopolysaccharide was injected into germ-free mice after they had been infected with Vero toxin-producing Escherichia coli. Microscopic examination of the kidneys of these mice showed an increased number of mesangial cells and a vacancy in the glomerular capillary lumen. A significant elevation in the expression level of interferon (IFN)-gamma in the kidney may have played a key role in the induction of glomerular lesions, because the administration of neutralizing antibody to IFN-gamma markedly alleviated such lesions.
Shimizu
K
K
Department of Nursing, Tokai University School of Health Sciences, Isehara, Japan.
Tanaka
K
K
Akatsuka
A
A
Endoh
M
M
Koga
Y
Y
D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000276:immunology / Q000473:pathology*; D005856:Germ-Free Life; D005920:Glomerular Mesangium / Q000187:drug effects / Q000473:pathology*; D007371:Interferon-gamma / Q000096:biosynthesis; D007678:Kidney Glomerulus / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D022622:Shiga Toxin 1
D001427:Bacterial Toxins; D008070:Lipopolysaccharides; D022622:Shiga Toxin 1; D007371:Interferon-gamma