title: Mechanism of GnRH receptor signaling: from the membrane to the nucleus.
abstract: The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase C beta. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.
authors.affiliation: Department of Biochemistry, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Shacham
authors.forename: M N
authors.initials: MN
authors.lastname: Cheifetz
authors.forename: H
authors.initials: H
authors.lastname: Lewy
authors.forename: I E
authors.initials: IE
authors.lastname: Ashkenazi
authors.forename: O M
authors.initials: OM
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Seger
authors.forename: Z
authors.initials: Z
authors.lastname: Naor
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D010740:Phospholipases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011966:Receptors, LHRH / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D011494:Protein Kinases; D010740:Phospholipases; D019204:GTP-Binding Proteins