title: Influence of increased macrolide consumption on macrolide resistance of common respiratory pathogens.
abstract: The impact of increased macrolide consumption on the resistance of common respiratory pathogens to erythromycin and azithromycin was evaluated. The study focused mainly on azithromycin. During the period from 1991 to 1996, a 3.5-fold increase in macrolide prescriptions for outpatients was observed in Slovenia. Compared to 1994, when no macrolide resistance was evident in Streptococcus pyogenes and noninvasive Streptococcus pneumoniae, a significant increase in macrolide resistance was observed in these two pathogens in 1997. Moraxella catarrhalis remained uniformly susceptible to macrolides. Close monitoring of macrolide resistance of common respiratory pathogens is thus necessary.
authors.affiliation: Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia.
authors.forename: M
authors.initials: M
authors.lastname: Cizman
authors.forename: M
authors.initials: M
authors.lastname: Pokorn
authors.forename: K
authors.initials: K
authors.lastname: Seme
authors.forename: M
authors.initials: M
authors.lastname: Paragi
authors.forename: A
authors.initials: A
authors.lastname: Orazem
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use; D011307:Drug Prescriptions; D004352:Drug Resistance, Microbial; D004363:Drug Utilization; D004917:Erythromycin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009016:Moraxella / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017963:Azithromycin