Teratogenic evaluation of oxacillin.
Teratogenic studies of oxacillin in humans have not been published. The population-based data-set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996 contains 22,865 foetuses or newborns with congenital abnormalities and 38,151 matched control newborns without congenital abnormalities. The mothers of 14 cases and 19 controls were treated with oral oxacillin during pregnancy. A teratogenic risk of oxacillin was not detected in this case-control study.
Czeizel
A E
AE
WHO Collaborating Centre for the Community Control of Hereditary Diseases, Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary.
Rockenbauer
M
M
Sørensen
H T
HT
Olsen
J
J
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007231:Infant, Newborn; D010068:Oxacillin / Q000009:adverse effects* / Q000627:therapeutic use; D010406:Penicillins / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy
D010406:Penicillins; D010068:Oxacillin