title: Gene silencing: RNA makes RNA makes no protein.
abstract: A mutation that disrupts post-transcriptional gene silencing in Neurospora crassa has been found to affect the homologue of a plant-encoded RNA-dependent RNA polymerase. This enzyme may produce a specificity determinant of gene silencing and mediate an epigenetic conversion at the RNA level.
authors.affiliation: The Sainsbury Laboratory, John Innes Centre, Norwich, NR4 7UH, UK. david.baulcombe@bbsrc.ac.uk
authors.forename: D C
authors.initials: DC
authors.lastname: Baulcombe
mesh_terms: D005656:Fungal Proteins / Q000235:genetics; D020868:Gene Silencing; D009154:Mutation; D009492:Neurospora crassa / Q000737:chemistry / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000502:physiology; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics* / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D016372:RNA, Antisense; C119303:QDE1 protein, Neurospora crassa; D012324:RNA-Dependent RNA Polymerase