Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro.
Silymarin, a standardized extract from Silybum marianum, inhibited in vitro the copper-induced oxidation of human LDL in a concentration-dependent manner. Silybin, a main flavonolignan of silymarin, appeared to be responsible for this LDL antioxidant effect. Silychristin and silydianin, other flavonolignans of silymarin, acted rather as pro-oxidants, but with regard to their content in silymarin, it did not contribute significantly to the reduction of the total LDL antioxidant capacity of silymarin.
Skottová
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Institute of Medical Chemistry, Medical Faculty, Palacký University, Hnevotínská 3, 775 15 Olomouc, Czech Republic.
Krecman
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Simánek
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D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D017705:Lignans / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000187:drug effects*; D008297:Male; D012838:Silymarin / Q000494:pharmacology*
D000975:Antioxidants; D005419:Flavonoids; D017705:Lignans; D008077:Lipoproteins, LDL; D012838:Silymarin; C099252:oxidized low density lipoprotein