Tc-99m-labeling of modified RNA.
The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 37MBq/nmol leading to 1:1-Tc-99m-N3S-aptamers.
Hilger
C S
CS
Schering AG, Research Laboratories, Berlin, FRG.
Willis
M C
MC
Wolters
M
M
Pieken
W A
WA
D001483:Base Sequence; D015609:Organotechnetium Compounds / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012313:RNA