Cholinergic neurons with monoamine oxidase type B (MAOB)-activity in the laterodorsal tegmental nucleus of the mouse.
No neurons in the laterodorsal tegmental nucleus (LDTg) show monoamine oxidase (MAO) activity in the rat or monkey. However, in our recent study, many LDTg neurons with MAO type B (MAOB)-activity were found in MAOA-deficient mice that were derived from C3H mouse line. In the present study, LDTg neurons with MAOB-activity were found not only in normal C3H mouse but also in BALB/C and C57BL/6 mouse lines: MAO histochemistry revealed LDTg neurons with MAO-activity even after pharmacological suppression of MAOA-activity with clorgyline, a specific MAOA inhibitor, but not after pharmacological suppression of MAOB-activity with deprenyl, a specific MAOB inhibitor. LDTg neurons with MAOB-activity also showed NADPH-diaphorase-activity, a marker of cholinergic neurons.
Ikemoto
K
K
Department of Anatomy, Fujita Health University, School of Medicine, Aichi, Japan. kikemoto@fujita-hu.ac.jp
Kitahama
K
K
Maeda
T
T
Jouvet
M
M
Nagatsu
I
I
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D005260:Female; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008995:Monoamine Oxidase / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D013045:Species Specificity; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000201:enzymology*
D007527:Isoenzymes; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline