title: Thymic carcinoma with neuroendocrine differentiation in a calf.
abstract: A neuroendocrine carcinoma originating in the thymus was found in a 7-month-old, castrated male, Japanese Black calf. The neoplasm consisted largely of very primitive cells, characterized by the paucity of cytoplasmic organelles, but a few cells were immunoreactive for somatostatin or neurofilaments. The expression of both cytokeratin and neurofilament protein was a feature of neuroendocrine differentiation. This neoplasm considered to be a tumor of a thymic stem cell, with little but indubitable evidence of differentiation into somatostatin-producing cells.
authors.affiliation: Animal Health Laboratory, Prefecture of Shimane, Izumo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Anjiki
authors.forename: K
authors.initials: K
authors.lastname: Kadota
mesh_terms: D000818:Animals; D018278:Carcinoma, Neuroendocrine / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D007633:Keratins / Q000032:analysis; D008297:Male; D008871:Microvilli / Q000473:pathology; D009919:Orchiectomy; D013953:Thymus Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*
chemical_list: D007633:Keratins