Juxtaglomerular cell tumor with retroperitoneal fibrosis and secondary immune-complex glomerulonephritis: a possible contribution of the renin angiotensin system to renal fibrosis.
We present a case of a 25-year-old woman with a renin-secreting juxtaglomerular cell tumor, retroperitoneal fibrosis associated with glomerular hypertrophy, glomerulonephritis, and marked tubulointerstitial alterations. Myofibroblasts, as shown by positive immunostaining for alpha-smooth muscle actin, were found along with transforming growth factor-beta (TGF-beta) in the interstitium of the tumor-free kidney. Regarding the pathogenesis of renal fibrosis and glomerular hypertrophy, this case may provide evidence not only experimentally but also clinically that the renin-angiotensin system plays an important role because angiotensin II is known to induce renal fibrosis associated with increased TGF-beta and the appearance of myofibroblasts.
Moriya
H
H
Second Department of Internal Medicine, National Defense Medical College, Namiki, Tokorozawa, Saitama, Japan.
Ishida
A
A
Nakabayashi
I
I
Nishiyama
J i
Ji
Kobayashi
S
S
D000199:Actins / Q000032:analysis; D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System; D012185:Retroperitoneal Fibrosis / Q000209:etiology / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000032:analysis*
D000199:Actins; D016212:Transforming Growth Factor beta; D012083:Renin