title: PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
authors.affiliation: Wyeth-Ayerst Research, Inc., CN 8000, Princeton, New Jersey 08543-8000, USA.
authors.forename: J
authors.initials: J
authors.lastname: Wrobel
authors.forename: J
authors.initials: J
authors.lastname: Sredy
authors.forename: C
authors.initials: C
authors.lastname: Moxham
authors.forename: A
authors.initials: A
authors.lastname: Dietrich
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: D R
authors.initials: DR
authors.lastname: Sawicki
authors.forename: L
authors.initials: L
authors.lastname: Seestaller
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: A
authors.initials: A
authors.lastname: Katz
authors.forename: D
authors.initials: D
authors.lastname: Sullivan
authors.forename: C
authors.initials: C
authors.lastname: Tio
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D051379:Mice; D008820:Mice, Obese; D008958:Models, Molecular; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D005663:Furans; D007004:Hypoglycemic Agents; D011994:Recombinant Proteins; D013876:Thiophenes; D017027:Protein Tyrosine Phosphatases