title: Effects of the 5-HT1A receptor agonist 8-OH-DPAT on operant food intake in food-deprived pigs.
abstract: The effects of the 5-HT1A agonist 8-hydroxy-2 (di-n-propylamino)tetralin (8-OH-DPAT) were investigated on operant food intake in food-deprived pigs. In Experiment 1, 8-OH-DPAT (5-20 microg/kg) administered intravenously (i.v.) 15 min prior to the occurrence of feeding produced a dose-related decrease in operant food intake in pigs that had been fasted overnight. The effects were mainly apparent during the first 30 min after the start of the feeding period. In Experiment 2, 8-OH-DPAT (25 and 50 microg/kg, i.v.) administered 60 min prior to the occurrence of feeding in pigs that were fasted overnight also produced significant decreases in food intake. The effects were mainly apparent during the first 30-40 min after the start of the feeding period. In Experiment 3, 8-OH-DPAT (20 microg/kg, i.v.) significantly increased operant feeding in satiated pigs during the first 30 min after administration. These results show that 8-OH-DPAT has complex effects on feeding behaviour in pigs, increasing operant food intake in satiated pigs, while producing a reduction in food intake in food-deprived animals.
authors.affiliation: MAFF Welfare and Behaviour Laboratory, The Babraham Institute, Cambridge, UK.
authors.forename: I S
authors.initials: IS
authors.lastname: Ebenezer
authors.forename: R F
authors.initials: RF
authors.lastname: Parrott
authors.forename: S V
authors.initials: SV
authors.lastname: Vellucci
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D001070:Appetitive Behavior / Q000187:drug effects / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D011985:Receptors, Serotonin / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013552:Swine; D013997:Time Factors
chemical_list: D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin