Antimicrobial activity of xanthones from Calophyllum species, against methicillin-resistant Staphylococcus aureus (MRSA).
During the past 5 years, a considerable number of known and new xanthones from the Calophyllum species of Sri Lanka have been isolated and characterized. We have investigated the antimicrobial activity of Calophyllum xanthones, with a special reference to methicillin-resistant Staphylococcus aureus (MRSA). These activity studies were carried out using the agar plate method. Calozeloxanthone, a xanthone which has been isolated from C. moonii and C. lankensis, showed the highest activity against methicillin-resistant S. aureus (MRSA) strains at a concentration of 8.3 microg/ml. Hence, calozeyloxanthone appears to hold promise as an antimicrobial agent in the treatment of infections with S. aureus, including methicillin-sensitive S. aureus (MRSA), and should be investigated further.
Dharmaratne
H R
HR
Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka.
Wijesinghe
W M
WM
Thevanasem
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008712:Methicillin / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects*; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C400965:calozeloxanthone; C400966:calozeyloxanthone; D008712:Methicillin