Effects of voriconazole on Candida glabrata in vitro.
The effects of voriconazole on the growth, morphology and lipids of Candida glabrata were studied. MIC data showed that voriconazole was up to 32- to 64-fold more active than fluconazole in its ability to inhibit various C. glabrata strains. Voriconazole inhibited the growth of C. glabrata in a dose-dependent fashion. Electron microscope examination showed that voriconazole treatment affected the external and internal morphology of C. glabrata. Treatment of C. glabrata with voriconazole inhibited ergosterol synthesis and led to accumulation of methylated sterols. In contrast, no significant difference in phospholipid composition was observed between treated and untreated cells.
Koul
A
A
Center for Medical Mycology, University Hospitals of Cleveland and Case Western Reserve University, OH 44106-5028, USA.
Vitullo
J
J
Reyes
G
G
Ghannoum
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000737:chemistry / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D015725:Fluconazole / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010743:Phospholipids / Q000032:analysis; D011743:Pyrimidines / Q000494:pharmacology*; D013261:Sterols / Q000032:analysis; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D010743:Phospholipids; D011743:Pyrimidines; D013261:Sterols; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole