title: Prognostic factors relating to survival in uterine endometrioid carcinoma.
abstract: OBJECTIVE
  Epidemiologic and clinicohistopathologic prognostic factors of uterine endometrioid carcinomas were analyzed. The association of estrogen related factors, focused on adenomyosis in the prognosis of endometrioid carcinomas was also examined.
  
  
  METHODS
  Risk factors of surgically treated 286 patients with endometrioid carcinoma (Stage I-III) were statistically analyzed.
  
  
  RESULTS
  Overall a recurrence-free 5-year survival rate was 81% (Stage I, 94%, Stage II, 71% and Stage III, 40%). Significant prognostic factors were lymph node metastases (P = 0.0035) and serosal/parametrial invasion (P = 0.014) by multivariate analysis. Endometrioid carcinomas with co-existing adenomyosis tend to be associated with endometrial hyperplasia (P = 0.04, Fisher's exact test), diagnosed in less invasive status (myometrial invasion, P = 0.004 and serosal/parametrial invasion, P = 0.006) and therefore have a favorable prognosis (P = 0.01, log rank test).
  
  
  CONCLUSIONS
  A favorable prognosis of endometrioid carcinomas with co-existing estrogen related factors (adenomyosis and endometrial hyperplasia) was suggested.
authors.affiliation: Department of Gynecologic Oncology, Chiba Cancer Center, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hirai
authors.forename: M
authors.initials: M
authors.lastname: Hirono
authors.forename: T
authors.initials: T
authors.lastname: Oosaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Yoshihara
authors.forename: O
authors.initials: O
authors.lastname: Matsuzaki
mesh_terms: D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000401:mortality* / Q000473:pathology* / Q000556:secondary; D004715:Endometriosis; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology*
chemical_list: D004967:Estrogens