8-aminoquinolines as anticoccidials - Part III.
Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.
Armer
R E
RE
Animal Health Discovery, Pfizer Central Research, Kent.
Barlow
J S
JS
Chopra
N
N
Dutton
C J
CJ
Greenway
D H
DH
Greenwood
S D
SD
Lad
N
N
Shaw
J
J
Thompson
A P
AP
Thong
K W
KW
Tommasini
I
I
D000634:Aminoquinolines / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D003049:Coccidiostats / Q000737:chemistry / Q000494:pharmacology*; D004539:Eimeria / Q000187:drug effects; D013329:Structure-Activity Relationship
D000634:Aminoquinolines; D003049:Coccidiostats