[Pathological changes in thrombocyte-vascular and coagulative hemostasis under the influence of lead chloride and their correction by using a synthetic analog of prostacyclin].
It has been established that plumbum chloride possesses a marked toxic action on the membranes of the formed elements, in particular, the thrombocytes, activates the release of the factors of thrombocyte aggregations, resulting in an increase of their adhesive and aggregation properties. The research studies the influence of the stable prostacycline analogue MM-706 and thrombocytic-vascular, as well as coagulative hemostasis in rats at a background of plumbum intoxication. We have discovered a marked protective action of MM-706 on the thrombocytes which is manifested through a decrease of the index of a spontaneous thrombocyte aggregation and percentage of adhesive thrombocytes, normalization of the general potential of hemocoagulation and time characteristics of a thromboelastogram.
Myslyts'kyĭ
V F
VF
Bucovinian State Medical Academy, Ministry of Public Health of the Ukraine, Chernovcsy.
Podolian
S K
SK
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D007854:Lead / Q000494:pharmacology*; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013916:Thrombelastography / Q000187:drug effects / Q000706:statistics & numerical data
D010975:Platelet Aggregation Inhibitors; C081773:MM 706; D007854:Lead; C029891:lead chloride; D011464:Epoprostenol