Antigen delivery by attenuated Bacillus anthracis: new prospects in veterinary vaccines.
This report summarizes the recent investigations on the use of Bacillus anthracis as a live vector for delivery of antigens. Recombinant strains were constructed by engineering the current live Sterne vaccine. This vaccine, used to prevent anthrax in cattle, causes side-effects due to anthrax toxin activities. Bacteria producing a genetically detoxified toxin factor were devoid of lethal effects and were as protective as the Sterne strain against experimental anthrax. Moreover, B. anthracis expressing a foreign antigen controlled by an in vivo inducible promoter were able to generate either antibody or cellular protective responses against heterologous diseases.
Brossier
F
F
Unité Toxines et Pathogénie Bactériennes, Institut Pasteur, Paris, France.
Mock
M
M
Sirard
J C
JC
D000818:Animals; D000881:Anthrax / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary*; D000942:Antigens, Bacterial / Q000276:immunology* / Q000627:therapeutic use; D001408:Bacillus anthracis / Q000276:immunology*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control; D014611:Vaccination; D014614:Vaccines, Synthetic
D000942:Antigens, Bacterial; D014614:Vaccines, Synthetic