title: MRI detection of suprasellar germinoma causing central diabetes insipidus.
abstract: This is a case report of an 18-year-old man with central diabetes incipidus (DI). An MRI done three months after the onset of the DI did not disclose a responsible lesion. Four months later, a second MRI showed the location of the tumor origin at the upper pituitary stalk and median eminence. Eight months later, the tumor occupied the hypothalamic area. The tumor became large and contrast-making enough to be visible on MRI between 3 and 4 months after the onst of DI. Besides the suprasellar tumor, another mass was noted in the pineal region. The growth pattern of the latter mass corresponded well to that of the former. Although the MRI is a sensitive diagnostic tool for the detection of intracranial tumors, no adequate rationale has been given as to how the MRI might be repeated for children and adolescents who have been diagnosed as having the central DI, when their initial MRIs may have been normal. In our patient, the superconductive thin slice MRI revealed the suprasellar germinoma 4 months after the onset. The suprasellar and pineal tumors in this report originated and developed simultaneously. This may indicate a multi-center origin of the tumor. Another possibility is a very early dissemination from the onset of the tumor development.
authors.affiliation: Department of Neurological Surgery, Chiba University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: D
authors.initials: D
authors.lastname: Uchida
authors.forename: I
authors.initials: I
authors.lastname: Tatsuno
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Yamaura
mesh_terms: D000293:Adolescent; D003131:Combined Modality Therapy; D003919:Diabetes Insipidus / Q000209:etiology*; D018237:Germinoma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D012658:Sella Turcica