title: Blastocyst implantation: effect of thyroidectomy and thyroxine replacement in the rat.
abstract: The long term effects of thyroidectomy and chronic thyroxine treatment on blastocyst implantations in female albino rats were studies. Implantation was delayed in both thyroidectomized and hyperthyroid rats, as there was no evidence of blastocyst implantation on day 6 of pregnancy. By day 9, when signs of implantation were observed, the number and weights of the implantation sites were significantly reduced in the athyroid and hyperthyroid rats. Both thyroidectomy and chronic thyroxine treatment significantly reduced the fetal sites and increased the incidence of resorptions when compared with the control. It is concluded that a functional thyroid gland is required for normal implantation to occur.
authors.affiliation: Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
authors.forename: A F
authors.initials: AF
authors.lastname: Bolarinwa
authors.forename: S B
authors.initials: SB
authors.lastname: Olaleye
mesh_terms: D000818:Animals; D001481:Basal Metabolism; D004195:Disease Models, Animal; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000209:etiology*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism; D007037:Hypothyroidism / Q000150:complications* / Q000378:metabolism; D010101:Oxygen Consumption; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013965:Thyroidectomy / Q000009:adverse effects*; D013974:Thyroxine / Q000494:pharmacology* / Q000502:physiology
chemical_list: D013974:Thyroxine