Genetic analysis of familial and multiple malignancies of endometrial cancer.
The presence of the positive replication errors (RER) phenotype in familial and multiple primary malignancies of endometrial cancer, and its association with a poor prognosis was examined. We analyzed 40 endometrial cancers for RER. Eight endometrial cancers with the RER(+) phenotype at multiple microsatellite loci were detected. The presence of the RER(+) phenotype was higher than in non-familial malignancies. None of the eight cases with the RER(+) phenotype involved multiple primary malignancies; however these patients had shorter survival times. In this study, we suggest that RER examination in endometrial cancer may be useful for establishing a diagnosis of a familial malignancy, and for predicting a poor prognosis.
Kobayashi
K
K
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Hokkaido, Japan.
Sagae
S
S
Takeda
T
T
Sugimura
M
M
Nishioka
Y
Y
Kudo
R
R
D016889:Endometrial Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D010641:Phenotype; D011379:Prognosis