Ketanserin, an antagonist of 5-HT2A receptor of serotonin, inhibits testosterone secretion by rat Leydig cells in vitro.
The effect of ketanserin, an antagonist of 5-HT2A receptor of serotonin, added to the culture medium, on basal and LH-stimulated testosterone secretion was studied in primary cultures of adolescent rat Leydig cells. Ketanserin decreased the basal secretion of testosterone but showed an insignificant influence on the LH-stimulated process. It can be concluded that ketanserin may affect the testosterone-secreting cells by an indirect action at the vascular level as well as directly at the level of Leydig cells, at least in adolescent rats, leading to down-regulation of the basal testosterone secretion.
Pieścikowska
I
I
Klein
P
P
Lukaszyk
A
A
Górska-Rafińska
L
L
Balcerek
M
M
Ludwiczak
H
H
D000818:Animals; D002478:Cells, Cultured; D007650:Ketanserin / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013739:Testosterone; D007650:Ketanserin