title: Detection of a Hodgkin/Reed-Sternberg cell specific immunoglobulin gene rearrangement in the serum DNA of a patient with Hodgkin's disease.
abstract: We analysed multiple serum samples from a patient with mixed cellularity Hodgkin's disease for the Hodgkin/Reed-Sternberg cell clone-specific rearranged Ig gene sequence. The clone-specific sequence could be detected in DNA extracted from a serum sample obtained during clinical relapse but not in serum samples obtained during or after treatment following relapse.
authors.affiliation: Department I of Internal Medicine, University of Cologne, Cologne, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kornacker
authors.forename: A
authors.initials: A
authors.lastname: Jox
authors.forename: M
authors.initials: M
authors.lastname: Vockerodt
authors.forename: H
authors.initials: H
authors.lastname: Tesch
authors.forename: H
authors.initials: H
authors.lastname: Bohlen
authors.forename: V
authors.initials: V
authors.lastname: Diehl
authors.forename: J
authors.initials: J
authors.lastname: Wolf
mesh_terms: D000328:Adult; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin / Q000235:genetics; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D016539:Reed-Sternberg Cells / Q000473:pathology*; D017422:Sequence Analysis, DNA