Antigenic variation in Plasmodium falciparum: mechanisms and consequences.
In the past year, the major advances in malaria antigenic variation have been concerned with the transcription and switching of variant antigen genes, and the functional expression of regions of the major variant antigen. Also, new variant gene families have been discovered as a result of the Malaria Genome Project.
Newbold
C I
CI
Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK. cnewbold@hammer.imm.ox.ac.uk
D000818:Animals; D000940:Antigenic Variation / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000235:genetics* / Q000276:immunology