title: Pulmonary autograft: should it be used in young patients with rheumatic disease?
abstract: BACKGROUND
  Although pulmonary autograft is being increasingly used to replace the diseased aortic valve with excellent long-term results, its use in the population with rheumatic disease still needs careful evaluation.
  
  
  METHODS
  From October 1993 through March 1998, 102 patients underwent aortic valve replacement with a pulmonary autograft (Ross procedure). The mean age was 27.9 +/- 4.2 years (range, 0.8-56 years). The cause was rheumatic disease in 75 patients (73%), bicuspid aortic valve in 26 patients (26%), and myxomatous aortoarteritis in 1 patient (1%). The root replacement technique was used in all. In addition, 31 patients had 33 associated procedures: mitral valve repair (n = 15 patients), open mitral commissurotomy (n = 15 patients), tricuspid repair (n = 2 patients), and homograft mitral valve replacement (n = 1 patient).
  
  
  RESULTS
  Operative mortality was 6.9% (7 patients). Late mortality was 7.8% (8 patients). Follow-up ranged from 1 to 60 months (mean, 25.3 +/- 15.4 months) and was 98% complete. Two patients required reoperation for failed mitral valve repair, and 2 other patients underwent reoperation for failure of both the autograft and mitral valve repair. Echocardiographic assessment showed moderate to severe aortic regurgitation in 13 patients, along with thickening of the autograft. All of these patients had rheumatic disease and were young (<30 years). Ten of these patients had undergone associated mitral valve procedure. Morphologic and histopathologic examination of explanted autografts showed features compatible with rheumatic valvulitis.
  
  
  CONCLUSIONS
  Pulmonary autograft is susceptible to rheumatic involvement. Young age (<30 years) and associated mitral valve disease are significant risk factors for autograft failure in patients with rheumatic disease. Use of pulmonary autograft in this subgroup of patients requires a cautious approach.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi.
authors.forename: S K
authors.initials: SK
authors.lastname: Choudhary
authors.forename: A
authors.initials: A
authors.lastname: Mathur
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Saxena
authors.forename: P
authors.initials: P
authors.lastname: Chopra
authors.forename: R
authors.initials: R
authors.lastname: Roy
authors.forename: A S
authors.initials: AS
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006349:Heart Valve Diseases / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011664:Pulmonary Valve / Q000637:transplantation*; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D014182:Transplantation, Autologous; D016896:Treatment Outcome