title: Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).
abstract: The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
authors.affiliation: School of Chemistry, University of Exeter, Devon, UK.
authors.forename: T
authors.initials: T
authors.lastname: Fryatt
authors.forename: D T
authors.initials: DT
authors.lastname: Goroski
authors.forename: Z D
authors.initials: ZD
authors.lastname: Nilson
authors.forename: C J
authors.initials: CJ
authors.lastname: Moody
authors.forename: H D
authors.initials: HD
authors.lastname: Beall
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011994:Recombinant Proteins / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000970:Antineoplastic Agents; D015363:Quinolones; D011994:Recombinant Proteins; D009247:NADH, NADPH Oxidoreductases