Neuropeptide Y has a stimulatory action on feeding behavior in goldfish (Carassius auratus).
The purpose of the present study was to elucidate the possible role of neuropeptide Y (NPY) in the feeding regulation in fish. We examined the effects of intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) neuropeptide Y administration on food intake in satiated goldfish, at different time intervals postinjection (0-2, 2-8 and 0-8 h). Food intake was significantly increased by i.c.v. administered neuropeptide Y (1 microg) at 2 h postinjection, while no significant differences in food intake were observed after i.p. treatment. The neuropeptide Y receptor antagonist, neuropeptide Y-(27-36), totally counteracted the stimulatory action of neuropeptide Y on feeding. The possible involvement of neuropeptide Y in the eating behavior evoked by food deprivation has been investigated. Food deprivation by either 24 or 72 h significantly increased feeding, and the neuropeptide Y receptor antagonist attenuated such feeding stimulation. From our findings, we suggest, first, that neuropeptide Y is involved in feeding central regulation in goldfish, acting via specific neuropeptide Y receptors, and second, that hypothalamic neuropeptide Y would be released in response to food deprivation, contributing to generate the consequent eating behavior stimulation in Carassius auratus.
López-Patiño
M A
MA
Departamento Biología Animal II, Facultad de Biología, Universidad Complutense de Madrid, Spain.
Guijarro
A I
AI
Isorna
E
E
Delgado
M J
MJ
Alonso-Bedate
M
M
de Pedro
N
N
D000818:Animals; D019167:Appetite Stimulants / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005215:Fasting / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects*; D006054:Goldfish / Q000502:physiology*; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007276:Injections, Intraventricular / Q000662:veterinary; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*
D019167:Appetite Stimulants; D009478:Neuropeptide Y