title: Is delayed gastric emptying following pancreaticoduodenectomy related to pylorus preservation?
abstract: BACKGROUND
  Delayed gastric emptying (DGE) is the most frequent postoperative complication after pylorus-preserving pancreaticoduodenectomy (PPPD). This prospective, non-randomized study was undertaken to determine whether the incidence of DGE may be reduced by modifying the original reconstructive anatomy with a retrocolic duodenojejunostomy towards an antecolic duodenojejunostomy.
  
  
  METHODS
  The study was comprised of 51 patients who underwent PPPD between August 1994 and November 1997. The operation was carried out as originally described but was modified by performing the duodenojejunostomy antecolically. Clinical data were recorded prospectively, with special regard to DGE.
  
  
  RESULTS
  After PPPD, the nasogastric tube could be removed at a median of 2 days (range 1-22 days) postoperatively; in two patients, the nasogastric tube was reinserted because of vomiting and nausea. A liquid diet was started at a median of 5 days (3-11 days); the patients were able to tolerate a full, regular diet at a median of 10 days (7-28 days). The overall incidence of DGE was 12% (n=6). No postoperative complications other than DGE were exhibited by 36 patients (71%). In this group, DGE was only seen in one patient (3%). In the second group, where postoperative complications other than DGE occurred (n=15), five patients (30%) exhibited DGE (P=0.002).
  
  
  CONCLUSIONS
  DGE after PPPD seems to be of minor clinical importance following uncomplicated surgery. When taking the results into consideration, it can be said that, despite the lack of a control group, antecolic duodenojejunostomy might be the key to a low incidence of DGE after PPPD. In our experience, DGE is linked to the occurrence of other postoperative complications rather than to pylorus preservation.
authors.affiliation: Department of General Surgery, Georg August University, Robert Koch Strasse 40, D-37075 Göttingen, Germany, ohorstm@med.uni-goettingen.de
authors.forename: O
authors.initials: O
authors.lastname: Horstmann
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: S
authors.initials: S
authors.lastname: Post
authors.forename: R
authors.initials: R
authors.lastname: Nustede
mesh_terms: D005260:Female; D005746:Gastric Emptying; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016577:Pancreaticoduodenectomy / Q000379:methods; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D011708:Pylorus / Q000502:physiology*