title: Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives.
abstract: Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.
authors.affiliation: Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, Belarus.
authors.forename: E I
authors.initials: EI
authors.lastname: Kvasyuk
authors.forename: I A
authors.initials: IA
authors.lastname: Mikhailopulo
authors.forename: R J
authors.initials: RJ
authors.lastname: Suhadolnik
authors.forename: E E
authors.initials: EE
authors.lastname: Henderson
authors.forename: N F
authors.initials: NF
authors.lastname: Muto
authors.forename: K T
authors.initials: KT
authors.lastname: Iacono
authors.forename: J
authors.initials: J
authors.lastname: Homon
authors.forename: W
authors.initials: W
authors.lastname: Pfleiderer
mesh_terms: D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001704:Biopolymers; D016048:Dideoxyadenosine / Q000737:chemistry*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000227:Adenine Nucleotides; D019380:Anti-HIV Agents; D001704:Biopolymers; D009843:Oligoribonucleotides; D018894:Reverse Transcriptase Inhibitors; D016048:Dideoxyadenosine; C023505:2',5'-oligoadenylate; D054303:HIV Reverse Transcriptase