title: Interferon beta-1a in relapsing-remitting multiple sclerosis.
abstract: The accumulated results from multiple trials have unequivocally demonstrated beneficial effects of interferon beta-1a on disease activity in relapsing-remitting multiple sclerosis, both for clinical and magnetic resonance endpoints. New data suggest that low doses administered once weekly are relatively ineffective and that higher, more frequent doses are required for optimal benefit.
authors.affiliation: Division of Clinical Neurology, University of Nottingham.
authors.forename: L
authors.initials: L
authors.lastname: Blumhardt
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta; D000068556:Interferon beta-1a