title: Allergic bronchopulmonary aspergillosis due to Aspergillus niger without bronchial asthma.
abstract: A 65-year-old woman was admitted to our hospital with a dry cough and pulmonary infiltrates. Chest radiograph and CT revealed mucoid impaction and consolidations. Peripheral blood eosinophilia and elevated serum IgE were observed. Aspergillus niger was cultured repeatedly from her sputum, but A. fumigatus was not detected. Immediate skin test and specific IgE (RAST) to Aspergillus antigen were positive. Precipitating antibodies were confirmed against A. niger antigen, but not against A. fumigatus antigen. She had no asthmatic symptoms, and showed no bronchial hyperreactivity to methacholine. Thus, this case was diagnosed as allergic bronchopulmonary aspergillosis (ABPA) without bronchial asthma due to A. niger, an organism rarely found in ABPA. The administration of prednisone improved the symptoms and corrected the abnormal laboratory findings.
authors.affiliation: Department of Respiratory Medicine, Hokkaido Keiaikai Minami Ichijyo Hospital, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: S
authors.initials: S
authors.lastname: Tagaki
authors.forename: H
authors.initials: H
authors.lastname: Kon
authors.forename: T
authors.initials: T
authors.lastname: Shibusa
authors.forename: H
authors.initials: H
authors.lastname: Takabatake
authors.forename: A
authors.initials: A
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Sekine
authors.forename: S
authors.initials: S
authors.lastname: Abe
mesh_terms: D000368:Aged; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis / Q000382:microbiology*; D001234:Aspergillus niger / Q000276:immunology* / Q000302:isolation & purification; D001249:Asthma; D005260:Female; D006801:Humans; D011852:Radioallergosorbent Test; D012882:Skin Tests