title: Neural source estimation from a time-frequency component of somatic evoked high-frequency magnetic oscillations to posterior tibial nerve stimulation.
abstract: OBJECTIVE
  High frequency oscillations (HFOs) evoked by posterior tibial nerve stimulation were recorded using magnetoencephalography (MEG). Time-frequency domain multiple signal classification (TF-MUSIC) algorithm was applied, and the usefulness of this method was demonstrated.
  
  
  METHODS
  Ten normal subjects were studied. To localize sources for the HFOs of those somatosensory evoked fields, we applied two kinds of methods: the single moving dipole (SMD) method and the TF-MUSIC method. The SMD method was applied after digitally band-pass filtering the somatosensory response with a bandwidth of 500-800 Hz. To estimate the locations of sources with the TF-MUSIC algorithm, we first set the target region on the spectrogram of the somatosensory responses. Then, the procedure described in Section 2.2 was applied with this target region.
  
  
  RESULTS
  A clear, isolated region was detected in 6 out of 10 subjects using a time-frequency spectrogram. The averaged distance of the dipole sources between the HFOs and the underlying P37m using the TF-MUSIC algorithm was smaller than using the SMD method.
  
  
  CONCLUSIONS
  The TF-MUSIC algorithm is suitable for extracting a target response whose spectrum changes significantly during the observation.
authors.affiliation: Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan. sakuma@nips.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sakuma
authors.forename: K
authors.initials: K
authors.lastname: Sekihara
authors.forename: I
authors.initials: I
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013979:Tibial Nerve / Q000502:physiology*