[The nonspecific reactivity of patients with tuberculosis of the respiratory organs and different haptoglobin phenotypes].
In patients with haptoglobin (Hp) 2-2, the incidence rate of tuberculosis of respiratory organs was found out to be 1.7 times as high as among patients with Hp 2-1 and 1-1; in those persons with aggravated heredity this parameter was 3.4 times as high. Based on the above data, in 414 first diagnosed cases with different phenotype pulmonary tuberculosis a comparative analysis has been done of certain factors of nonspecific bodily reactivity, which showed that in patients with Hp 2-2 versus Hp 2-1 blood levels of total haptoglobin, ceruloplasmin get decreased while total proteolytic activity is noted to be on the increase. The lysozyme concentration is significantly lower than in patients with Hp 2-1 and remains within the normal range. Poorly manifest reaction to the infectious agent of ceruloplasmin, total Hp, lysozyme which have distinct effects and are interrelated with mechanisms of immune defense creates a favourable background in subjects with Hp 2-2 for origination, development and progressing of the tuberculous process.
Platonova
I L
IL
D015415:Biomarkers / Q000097:blood; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D010641:Phenotype; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000235:genetics / Q000276:immunology*
D015415:Biomarkers; D006242:Haptoglobins