title: Synthesis of modified thiopurine nucleosides for structural characterization of human thiopurine S-methyltransferase.
abstract: Synthesis of a number of photoactive thiopurine-containing nucleosides was described. S-methylation of the synthesized compounds in the course of the reaction catalyzed by recombinant human thiopurine S-methyltransferase was studied by UV-spectroscopy.
authors.affiliation: Belozersky Institute, Moscow, Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Korshunova
authors.forename: E Y
authors.initials: EY
authors.lastname: Krynetski
authors.forename: M T
authors.initials: MT
authors.lastname: Mtchedlidze
authors.forename: D V
authors.initials: DV
authors.lastname: Agapkin
authors.forename: W E
authors.initials: WE
authors.lastname: Evans
authors.forename: N F
authors.initials: NF
authors.lastname: Krynetskaia
mesh_terms: D006801:Humans; D008780:Methyltransferases / Q000737:chemistry*; D011487:Protein Conformation; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011994:Recombinant Proteins / Q000737:chemistry
chemical_list: D011684:Purine Nucleosides; D011994:Recombinant Proteins; D008780:Methyltransferases; C022745:thiopurine methyltransferase