title: Investigations into the prevention of neonatal Ancylostoma caninum infections in puppies by application of moxidectin to the bitch.
abstract: The aim of this investigation was to examine whether reactivated Ancylostoma caninum larvae can be eliminated by the administration of moxidectin to pregnant bitches. Four pregnant bitches infected experimentally with 20,000 third-stage larvae of A. caninum were treated subcutaneously with 1 mg moxidectin/kg body weight on day 55 of the pregnancy (5-8 days before parturition). Another four experimentally infected pregnant bitches served as controls. The single moxidectin treatment completely prevented lactogenic infections in the puppies. Neither intestinal stages nor somatic larvae could be found. The administration of moxidectin caused no local or systemic side-effects in the bitches. All 22 puppies of the treated bitches were born healthy and remained so during the whole trial period. Beginning during the third week after birth, all 20 puppies of the untreated bitches developed a severe microcytic, hypochromic anaemia and they revealed a total of 8649 intestinal stages of A. caninum after autopsy.
authors.affiliation: Institute of Parasitology, Hannover School of Veterinary Medicine, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Epe
authors.forename: K
authors.initials: K
authors.lastname: Roesler
authors.forename: T
authors.initials: T
authors.lastname: Schnieder
authors.forename: M
authors.initials: M
authors.lastname: Stoye
mesh_terms: D000722:Ancylostoma / Q000187:drug effects*; D000724:Ancylostomiasis / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D000831:Animals, Newborn; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000032:analysis; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D004285:Dogs; D005243:Feces / Q000469:parasitology; D005260:Female; D018942:Macrolides; D051379:Mice; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000909:Antibodies, Helminth; D018942:Macrolides; C027837:moxidectin