title: In vitro studies on the effects of some anthelmintics on Cotylophoron cotylophorum (Digenea, Paramphistomidae): a structural analysis.
abstract: The effects of the anthelmintics praziquantel (PZQ), levamisole (LEV), mebendazole (MBZ), fenbendazole (FBZ) and albendazole (ABZ), on the morphology and the histology of a digenetic trematode, Cotylophoron cotylophorum, were studied. Scanning electron micrographs of the drug-treated worms revealed that PZQ was the most effective drug inducing surface damages to a great extent. The parasite exposed to PZQ for 6 h, showed smaller blebs on the oral sucker region as well as on the sensory papillae. These blebs enlarged in size after 24 h and ruptured after 30 h of exposure. The worms treated with LEV showed a few smaller blebs on the ventrolateral margin. In MBZ- and FBZ-treated worms the blebs appeared between the oral and genital sucker after 6 h of incubation. The changes were not apparent in the ABZ-treated worms.
authors.affiliation: Department of Zoology, University of Madras, Chennai, India.
authors.forename: L
authors.initials: L
authors.lastname: Veerakumari
authors.forename: N
authors.initials: N
authors.lastname: Munuswamy
mesh_terms: D015766:Albendazole / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D005273:Fenbendazole / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology*; D008463:Mebendazole / Q000494:pharmacology; D010250:Paramphistomatidae / Q000033:anatomy & histology / Q000187:drug effects*; D011223:Praziquantel / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D007978:Levamisole; D005273:Fenbendazole; D011223:Praziquantel; D008463:Mebendazole; D015766:Albendazole