title: Factors associated with impairments in new leprosy patients: the AMFES cohort.
abstract: Data on the importance of the delay between onset of symptoms and registration as a risk factor for impairment are sparse. This study investigates the quantitative relationship between this delay, other risk factors and the impairment status in new leprosy patients. It reports on 592 new leprosy patients enrolled in 1988-1992 in the prospective ALERT MDT Field Evaluation Study in central Ethiopia (AMFES). The influence of the risk factors sex, age, delay, PB/MB classification in relation to BI, and prior dapsone treatment on the impairment status at intake is analysed. Estimates for the delay are based on patient recall. For the risk factors, odds ratios on impairment and on severity of impairment were calculated using both univariate and multivariate logistic regression. The registration delay was 2 years or more for 44% of new patients. The prevalence of impairment (WHO impairment grades 1 and 2 combined) increased continuously from 36% for new patients with a delay of 0-1 year to 81% for new patients with delays of 4 years or more. This prevalence also increased continuously with age; it rose from 26% in children to 80% for the age group 60 and over. In the multivariate regression, the odds ratios for new patients to be impaired were statistically significant for all delay categories (baseline 1-2 years) and age groups (baseline 15-29 years). No statistically significant differences in odds ratios were observed with respect to sex and PB/MB classification in relation to BI. Overall, 31% of new patients presented with WHO impairment grade 1 and 23% with grade 2. The risk on grade 2 also increased with the registration delay amongst the impaired new patients. Relatively few impaired males and relatively few impaired MB patients with a BI value of 3 or higher had grade 2 impairment. Registration delay and age are the main risk factors for presentation with impairment. Reduction of delay in central Ethiopia requires re-thinking of control methodologies. The search for ways to reduce delays in diagnosis and treatment should receive high priority in leprosy research and in leprosy control programmes.
authors.affiliation: Department of Public Health, Erasmus University Rotterdam, The Netherlands. Meima@mgz.fgg.eur.nl
authors.forename: A
authors.initials: A
authors.lastname: Meima
authors.forename: P R
authors.initials: PR
authors.lastname: Saunderson
authors.forename: S
authors.initials: S
authors.lastname: Gebre
authors.forename: K
authors.initials: K
authors.lastname: Desta
authors.forename: G J
authors.initials: GJ
authors.lastname: van Oortmarssen
authors.forename: J D
authors.initials: JD
authors.lastname: Habbema
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004185:Disability Evaluation; D004359:Drug Therapy, Combination; D005002:Ethiopia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D007917:Leprostatic Agents