Protein and RNA of human telomerase as targets for modified oligonucleotides.
Chimeric oligodeoxynucleotides containing phosphorothioate and N3'-->P5' phosphoramidate linkages were synthesized. These oligomers show a high inhibitory activity against human telomerase.
von Janta-Lipinski
M
M
Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Gaertner
K
K
Lehmann
C
C
Scheer
H
H
Schildt
J
J
Matthes
E
E
D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009841:Oligonucleotides / Q000494:pharmacology*; D012313:RNA / Q000187:drug effects*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D012313:RNA; D019098:Telomerase