Origin and evolution of binucleate cells in cultures of HEp-2 cells.
The origin and evolution of binucleate cells in cultures of HEp-2 cells have been studied by means of interval photography and time-lapse video-recording. Binucleate cells most frequently formed by the fusion of two sister cells born in a previous mitosis. The study of binucleate cells has shown that they are a cellular type able to successfully undergo mitosis. However, the mitosis may be bipolar, tripolar or multipolar. The daughter cells arising from these divisions do not follow a clear pattern in the number of nuclei they have, instead showing a wide range of possibilities.
Serrano
A
A
Departament de Biologia Animal, Universitat de València, Spain.
Rodilla
V
V
Pellicer
J A
JA
Pertusa
J
J
D002277:Carcinoma / Q000473:pathology*; D002459:Cell Fusion; D002467:Cell Nucleus / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008938:Mitosis; D014407:Tumor Cells, Cultured