title: Incidence of thyroid cancer in Scandinavia following fallout from atomic bomb testing: an analysis of birth cohorts.
abstract: OBJECTIVE
  The occurrence relation between radioactive fallout from nuclear testing at Novaja Semlja in north-west Russia and the incidence of thyroid cancer in Norway and Sweden was studied following a birth cohort approach.
  
  
  METHODS
  Birth cohorts with presumably different levels of exposure were identified according to calendar year of atomic tests and previous Norwegian estimates of the population dose (born 1947-1950 received low exposure in late childhood, born 1951-1962 received the highest exposure in early childhood, born 1963-1970 were not exposed). For each one-year birth cohort the incidence rates were calculated, with denominators based on exact population figures for each year of follow-up.
  
  
  RESULTS
  In a stratified analysis, the relative risk for the highest exposed cohorts born 1951-1962, compared to those not exposed born 1963-1970, was found to decrease with increasing age from a borderline significant relative risk (RR) of 1.7 (95 percent confidence interval, 95% CI: 1.0-3.0) for children in the age-group 7-14 years to no excess risk among those 20-24 years of age (RR: 0.9; 95% CI: 0.7-1.2). The mean age at diagnosis of thyroid cancer in the age-group 7 14 years was lowest in the birth cohorts with the highest exposure. The Poisson regression analysis showed essentially the same results, with an improved fit when adding an interaction term between age and birth-cohort to a basic model with age, gender, birth-cohort and country.
  
  
  CONCLUSIONS
  These results are compatible with an increased risk of thyroid cancer during childhood and adolescence for subjects exposed to radioactive fallout early in life. Alternative explanations for the pattern of incidence are discussed.
authors.affiliation: Institute of Community Medicine, University of Tromsø, Norway.
authors.forename: E
authors.initials: E
authors.lastname: Lund
authors.forename: M R
authors.initials: MR
authors.lastname: Galanti
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D015331:Cohort Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009689:Nuclear Warfare; D011847:Radioactive Fallout / Q000009:adverse effects*; D018570:Risk Assessment; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology
chemical_list: D011847:Radioactive Fallout