The etiology and treatment of traumatic and septic shock.
Disseminated intravascular coagulation can cause multiple organ failure including adult respiratory distress syndrome by obstruction of visceral microcirculation by microclots. It was reasoned that if a clot causes vascular obstruction, lysing the clot by a plasminogen activator would be of value.
Hardaway
R M
RM
Department of Surgery, Texas Tech University Health Sciences Center, El Paso 79905, USA.
D000328:Adult; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control; D010960:Plasminogen Activators / Q000627:therapeutic use; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000628:therapy; D012772:Shock, Septic / Q000209:etiology* / Q000628:therapy*; D012774:Shock, Traumatic / Q000209:etiology* / Q000628:therapy*; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator