Modification of subcutaneous adipose tissue by a methylxanthine formulation: a double-blind controlled study.
BACKGROUND
Excessive subcutaneous adipose tissue is typically treated by physically removing the fat through liposuction, but cost and accessibility have popularized alternative treatments for reducing adipose tissue thickness.


OBJECTIVE
The purpose of this study was to test the absolute and relative effectiveness of a liposome-encapsulated caffeine-based cream in modifying subcutaneous adipose tissue.


METHODS
Forty-one patients consented and completed the double-blind, single-center, placebo-controlled study. Caliper measurements, tape measurements, and photographs were taken over a 2-month period.


RESULTS
Both concentrations of the cream were found to significantly reduce the thickness of the adipose tissue in all areas of the body. In addition, the more concentrated cream was significantly more effective than the less concentrated cream in the areas of the hips and the triceps.


CONCLUSIONS
The caffeine-based liposome-encapsulated cream significantly reduced the thickness of the subcutaneous fat over a 2-month period.
Lesser
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Ritvo
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Moy
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D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000886:Anthropometry; D002110:Caffeine / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004337:Drug Carriers; D005260:Female; D006801:Humans; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D009824:Ointments; D014970:Xanthines / Q000008:administration & dosage* / Q000494:pharmacology
D004337:Drug Carriers; D008081:Liposomes; D009824:Ointments; D014970:Xanthines; C008514:methylxanthine; D002110:Caffeine