Radiopaque 2,8-dihydroxyadenine lithiasis.
2,8-Dihydroxyadenine (DHA) lithiasis is a rare type of urinary stone disease and the deficiency of adenine phosphoribosyltransferase (APRT) activity is known to be the cause of this disease. To identify a 2,8-DHA stone is important because this stone is well managed by medical therapy. Regarding a radiological finding, previous reports have considered 2,8-DHA to be radiolucent like uric acid stone. This report is a case of radiopaque 2,8-DHA stone and proposes that the composition of urinary stones should always be investigated for adequate medical treatment.
Yagisawa
T
T
Department of Urology, Tokyo Women's Medical College, Japan.
Yamazaki
Y
Y
Toma
H
H
Kamatani
N
N
D000225:Adenine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D000228:Adenine Phosphoribosyltransferase / Q000172:deficiency / Q000235:genetics; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry* / Q000000981:diagnostic imaging* / Q000235:genetics; D008875:Middle Aged; D011859:Radiography; D013057:Spectrum Analysis
C002993:2,8-dihydroxyadenine; D000228:Adenine Phosphoribosyltransferase; D000225:Adenine