title: A case of seizures 1 week after the cessation of interferon-alpha therapy.
abstract: We report on a 60-year-old woman with a history of bipolar mood disorder who had seizures and developed a delirious state 1 week after the cessation of interferon-alpha (IFN-alpha) for chronic hepatitis C. The IFN-alpha was administered to the patient for 7 weeks (266 million IU). One week after the cessation of IFN-alpha therapy, the patient had four generalized tonic-clonic seizures over a 2-day period and developed a delirious state for 2 months. We consider these seizures and delirious state to be related to IFN-alpha.
authors.affiliation: Department of Psychiatry, Shimane Medical University, Izumo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Seno
authors.forename: T
authors.initials: T
authors.lastname: Inagaki
authors.forename: M
authors.initials: M
authors.lastname: Itoga
authors.forename: T
authors.initials: T
authors.lastname: Miyaoka
authors.forename: H
authors.initials: H
authors.lastname: Ishino
mesh_terms: D003693:Delirium / Q000139:chemically induced / Q000175:diagnosis; D003700:Delta Rhythm; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000187:drug effects; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis*
chemical_list: D016898:Interferon-alpha