title: Effects of Dai-kenchu-to on intestinal obstruction following laparotomy.
abstract: To confirm the usefulness of Dai-kenchu-to for intestinal obstruction, investigation of the effects of Dai-kenchu-to on postoperative intestinal adhesion was conducted. Repeated administrations of Dai-kenchu-to (100 or 300 mg/kg) significantly inhibited the formation of intestinal obstruction. Motor disturbance and inflammation are thought to be involved in the etiology of intestinal adhesion. A single treatment of Dai-kenchu-to (300 mg/kg) significantly reduce intestinal transit time in postoperative ileus and chemically induced ileus. Dai-kenchu-to (10(-4) g/ml) significantly inhibited COX-2 activity. These results suggest that Dai-kenchu-to prevents postoperative intestinal adhesion by gastroprokinetic and anti inflammatic effects. Dai-kenchu-to thus demonstrates positive effect on postoperative ileus.
authors.affiliation: Central Research Laboratories, Tsumura & Co., Ibaraki, Japan. hayakawa_terumasa@mail.tsumura.co.jp
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kase
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: A
authors.initials: A
authors.lastname: Ishige
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects*; D007415:Intestinal Obstruction / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D005894:Panax; D004364:Pharmaceutical Preparations; D010936:Plant Extracts / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013627:Talc / Q000009:adverse effects; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D032106:Zanthoxylum; D030521:Zingiberaceae
chemical_list: D004365:Drugs, Chinese Herbal; D004364:Pharmaceutical Preparations; D010936:Plant Extracts; C121414:dai-kenchu-to; D013627:Talc; D011451:Prostaglandin-Endoperoxide Synthases