Rise in plasma oxidized glutathione by experimental hypoglycemia.
Changes in plasma glutathione were investigated under hypoglycemic status. Twelve rabbits were randomly divided into hypoglycemic group (n=6) and saline-injected control group (n=6). Hypoglycemia was induced by intravenous injection of insulin as 10 U/kg and recovered by intravenous glucose injection after 60 minutes. In the control group, saline was intravenously injected in stead of insulin. Plasma levels of oxidized glutathione (GSSG) rose significantly (p<0.01) and remarkably decrease in plasma GSH/GSSG ratio (p<0.05) accompanying increase in serum enzymes in the hypoglycemic group. These results suggest that hypoglycemia might cause change in plasma GSSG which is related to increase of serum enzymes by hypoglycemia.
Jiang
Z L
ZL
The Section of Internal Medicine and Disability Prevention, Disability Science, Division of Medicine, Tohoku University Graduate School, Sendai, Japan. zhongli@mail.cc.tohoku.ac.jp
Sato
T
T
D000818:Animals; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D019803:Glutathione Disulfide / Q000097:blood*; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007004:Hypoglycemic Agents; D007328:Insulin; D008297:Male; D011817:Rabbits
D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D019803:Glutathione Disulfide