title: Determination of extent and activity with radionuclide imaging in Erdheim-Chester disease.
abstract: Erdheim-Chester disease usually involves the diaphyseal and metaphyseal regions of tubular bones and various visceral organs. A 56-year-old woman presented with the histologically confirmed diagnosis of Erdheim-Chester disease. A Tc-99m MDP bone scan revealed the entire extent of the skeletal disease and showed unusual involvement of the epiphyses and axial skeleton. In addition to MRI, a Ga-67 citrate scan including SPECT showed extensive soft-tissue infiltration of different organs. Both Tc-99m MDP and Ga-67 scintigraphy are useful tools in determining the distribution of this rare disease.
authors.affiliation: Department of Nuclear Medicine, University Hospital, Westfälische Wilhelms-Universität, Münster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Franzius
authors.forename: J
authors.initials: J
authors.lastname: Sciuk
authors.forename: C
authors.initials: C
authors.lastname: Bremer
authors.forename: M
authors.initials: M
authors.lastname: Kempkes
authors.forename: O
authors.initials: O
authors.lastname: Schober
mesh_terms: D001706:Biopsy; D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D001927:Brain Diseases / Q000000981:diagnostic imaging; D018483:Diaphyses / Q000000981:diagnostic imaging; D004838:Epiphyses / Q000000981:diagnostic imaging; D005260:Female; D005487:Foam Cells / Q000473:pathology; D005710:Gallium Radioisotopes; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging; D008875:Middle Aged; D009916:Orbital Diseases / Q000000981:diagnostic imaging; D010305:Parotid Diseases / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate; D015899:Tomography, Emission-Computed, Single-Photon; D014973:Xanthomatosis / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate