title: Genetic analysis of familial and multiple malignancies of endometrial cancer.
abstract: The presence of the positive replication errors (RER) phenotype in familial and multiple primary malignancies of endometrial cancer, and its association with a poor prognosis was examined. We analyzed 40 endometrial cancers for RER. Eight endometrial cancers with the RER(+) phenotype at multiple microsatellite loci were detected. The presence of the RER(+) phenotype was higher than in non-familial malignancies. None of the eight cases with the RER(+) phenotype involved multiple primary malignancies; however these patients had shorter survival times. In this study, we suggest that RER examination in endometrial cancer may be useful for establishing a diagnosis of a familial malignancy, and for predicting a poor prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, Hokkaido, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Sagae
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Sugimura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishioka
authors.forename: R
authors.initials: R
authors.lastname: Kudo
mesh_terms: D016889:Endometrial Neoplasms / Q000235:genetics* / Q000401:mortality; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D010641:Phenotype; D011379:Prognosis