Osteoconductive materials and their role as substitutes for autogenous bone grafts.
The term osteoconduction applies to a three-dimensional process that is observed when porous structures are implanted into or adjacent to bone. Capillaries, perivascular tissues, and osteoprogenitor cells migrate into porous spaces and incorporate the porous structure with newly formed bone. The observed process is characterized by an initial ingrowth of fibrovascular tissue that invades the porous structure followed by the later development of new bone applied directly within it. This article reviews observations of commonly used osteoconductive matrices to increase understanding of this process.
Cornell
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Department of Surgery, Weill College of Medicine of Cornell University, Hospital for Special Surgery, New York Hospital Medical Center of Queens, Queens, New York, USA.
D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D018786:Bone Substitutes / Q000737:chemistry / Q000627:therapeutic use; D016025:Bone Transplantation; D001842:Bone and Bones / Q000601:surgery; D002196:Capillaries / Q000502:physiology; D002465:Cell Movement; D003238:Connective Tissue / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000502:physiology; D016062:Porosity; D013234:Stem Cells / Q000502:physiology; D013499:Surface Properties; D014182:Transplantation, Autologous
D001672:Biocompatible Materials; D018786:Bone Substitutes