Insulin-stimulated taurine uptake in rat retina and retinal pigment epithelium.
Taurine is found at millimolar concentration in the retina and retinal pigment epithelium. High concentrations of taurine are essential for maintenance of retinal function. Taurine uptake by retina and retinal pigment epithelium was significantly enhanced by physiological concentrations of insulin as well as by high glucose concentrations. The results indicate that both, glucose and insulin enhanced taurine uptake occur through an increase in transport capacity which offset an additional, small decrease in affinity of the taurine carrier. Similar results were observed in retina and retinal pigment epithelium from streptozotocin-induced diabetic rats, suggesting that glucose and insulin regulate the taurine carrier through the same mechanism.
Salceda
R
R
Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, D.F., Mexico. rsalceda@ifisiol.unam.mx
D000818:Animals; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D007328:Insulin; D013654:Taurine