title: Papillary adenoma of the distal common bile duct.
abstract: A 73-year-old man with a papillary adenoma located in the distal common bile duct is reported. He underwent pylorus-preserving pancreatoduodenectomy. The lesion in the common bile duct featured papillary proliferation of the epithelium and fibrous elements with diffuse infiltration by inflammatory cells. Positive staining for MIB-1 (Ki-67) and p53 was identified in the nuclei of the proliferative epithelium. These findings suggested the malignant potential of this lesion. Further progress in imaging diagnostic techniques should increase the frequency with which such lesions are discovered. Even now, if mural irregularities and defects are found in the extrahepatic biliary system, especially the distal common bile duct, the possibility of such borderline biliary adenoma should be taken into consideration when making a diagnosis.
authors.affiliation: Second Department of Surgery, Asahikawa Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inagaki
authors.forename: A
authors.initials: A
authors.lastname: Ishizaki
authors.forename: S
authors.initials: S
authors.lastname: Kino
authors.forename: K
authors.initials: K
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Yokoyama
authors.forename: I
authors.initials: I
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Ojima
authors.forename: Y
authors.initials: Y
authors.lastname: Tokusashi
authors.forename: N
authors.initials: N
authors.lastname: Miyokawa
authors.forename: S
authors.initials: S
authors.lastname: Kasai
mesh_terms: D002759:Adenoma, Bile Duct / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003138:Common Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D019160:Endosonography; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000473:pathology; D016577:Pancreaticoduodenectomy; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53