title: Prevalence of anti-delta antibodies in central India.
abstract: A total of 238 sera samples from cases of hepatitis, renal failure, thalassaemia, healthy health care workers (HCWs) & asymptomatic HBsAG carriers coming from central India from July 1992 to June 1998, were screened for anti-delta antibodies. Among 238 subjects, 206 were reactive for hepatitis B surface antigen (HBsAg) while 32 were HBsAg non-reactive. The prevalence of anti-delta antibodies was low (1.9%) among 54 patients of acute viral hepatitis (AVH) while it was higher (5.7%) among 52 patients of chronic liver disease (CLD). The anti-delta antibodies positivity among 34 patients with hepatic failure was around 15% and all of them were FHF patients. Among multitransfused subjects such as chronic renal failure (CRF) the prevalence of anti-delta antibodies was low (2.3%). None of the apparently healthy HBsAg reactive HCWs and asymptomatic HBV carriers were reactive for anti-delta antibodies. Similarly anti-delta antibodies could not be detected in HBsAg negative viral hepatitis patients. There is a wide variation in the prevalence of anti-delta antibodies in different parts of India. However, overall prevalence of anti-delta antibodies appears to be lower in the Indian population in comparision to western countries.
authors.affiliation: Choithram Hospital and Research Centre, Indore, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Jaiswal
authors.forename: D S
authors.initials: DS
authors.lastname: Chitnis
authors.forename: K K
authors.initials: KK
authors.lastname: Artwani
authors.forename: G
authors.initials: G
authors.lastname: Naik
authors.forename: A K
authors.initials: AK
authors.lastname: Jain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood*; D019701:Hepatitis D, Chronic / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D003698:Hepatitis Delta Virus / Q000276:immunology*; D006801:Humans; D007194:India / Q000453:epidemiology; D008107:Liver Diseases / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies