Solution and adsorption behaviour of lecithin surfactants in CFC suspensions: a light scattering study in aerosol propellants.
The behaviour of the lecithin Epikuron 200 was studied in solution in a chlorofluorocarbon (CFC) aerosol propellant (P113) using light scattering to determine the micellar structure as a function of temperature. At room temperature Epikuron 200 formed micelles with a radius of approximately 25 nm. The radius increased with decreasing temperature until a phase boundary was reached at 15-16 degrees C, below which the micellar radius increased rapidly to 150-250 nm. This was accompanied by a large increase in the viscosity and turbidity of the solution. We consider that this behaviour is due to the formation of large wormlike micelles similar to those reported for lecithin in cyclohexane. The adsorption of Epikuron 200 on salbutamol sulphate was measured over this temperature range. The adsorbed amount of Epikuron 200 increased with decreasing temperature, and the hemimicelle concentration decreased rapidly at a temperature corresponding to the threshold for the formation of wormlike micelles. It is likely that these structures do form in CFC-MDI systems (particularly during cold-fill formulation), and that the structure of the adsorbed surfactant layer changes at low temperature. This may have implications for the formulation of stable aerosol suspensions.
Malik
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School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, UK.
Washington
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Purewal
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TS
D000327:Adsorption; D000336:Aerosols; D017402:Chlorofluorocarbons / Q000008:administration & dosage*; D008027:Light; D008823:Micelles; D009330:Nebulizers and Vaporizers; D010713:Phosphatidylcholines / Q000737:chemistry*; D012542:Scattering, Radiation; D012996:Solutions; D013501:Surface-Active Agents / Q000737:chemistry*; D013535:Suspensions
D000336:Aerosols; D017402:Chlorofluorocarbons; D008823:Micelles; D010713:Phosphatidylcholines; D012996:Solutions; D013501:Surface-Active Agents; D013535:Suspensions