Relative 99mTc-MAG3 renal uptake: reproducibility and accuracy.
The aim of this study was to estimate the reproducibility and accuracy of 99mTc-mercaptoacetyltriglycine (MAG3) relative percentage uptake.


METHODS
Reproducibility was evaluated on healthy volunteers who were submitted twice to a 99mTc-MAG3 renographic study, which used different uptake algorithms, different background corrections and different time intervals. Accuracy was evaluated in a group of patients with symmetrical or asymmetrical relative renal function, who underwent both 99mTc-dimercaptosuccinic acid (DMSA) and 99mTc-MAG3 studies, using the DMSA relative percentage uptake as a reference.


CONCLUSIONS
The methods that combined the best reproducibility and accuracy for estimating 99mTc-MAG3 left-to-right uptake ratio were the integral method, with subrenal or perirenal background correction, and the Patlak-Rutland plot. The use of the integral method without background correction introduced a systematic bias, whereas the slope method resulted in high variability. Therefore these methods cannot be recommended.
Piepsz
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A
Department of Radioisotopes, Centre Hospitalo-Universitaire Saint-Pierre Brussels, Belgium.
Tondeur
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M
Ham
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H
D000328:Adult; D000465:Algorithms; D003627:Data Interpretation, Statistical; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000502:physiology*; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D017263:Technetium Tc 99m Mertiatide; D013997:Time Factors
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D019783:Technetium Tc 99m Dimercaptosuccinic Acid