title: [Effects of sodium nucleinate on immunological and nonspecific responsiveness in elderly and senile patients].
abstract: Sixty-two elderly and senile patients with pulmonary tuberculosis were examined. Of them 32 had multimodality therapy involving sodium nucleinate. The inclusion of sodium nucleinate into a complex of therapeutical measures for the patients promotes improvement of T-cellular immunity. The patients taking sodium nucleinate were also found to have enhanced specific immunity against tuberculosis. In these patients, stimulation of immunity and nonspecific responsiveness is accompanied by the higher clinical benefits of treatment, as shown by shorter periods in abacillation, in the cessation of signs of intoxication, and in the resolution of infiltrative events and in the closure of decay cavities.
authors.forename: D A
authors.initials: DA
authors.lastname: Adambekov
authors.forename: V I
authors.initials: VI
authors.lastname: Litvinov
authors.forename: A G
authors.initials: AG
authors.lastname: Koshmuratov
authors.forename: K B
authors.initials: KB
authors.lastname: Mambetov
authors.forename: T S
authors.initials: TS
authors.lastname: Sabyrbekova
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D009696:Nucleic Acids / Q000494:pharmacology*; D012331:RNA, Fungal; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects / Q000276:immunology*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents; D009696:Nucleic Acids; D012331:RNA, Fungal; C013683:sodium nucleinate