title: Nematode ageing: Putting metabolic theories to the test.
abstract: The increased life span caused by certain mutations in the nematode Caenorhabditis elegans has been interpreted in terms of two metabolic theories of ageing: the oxidative damage theory and the rate of living theory. New findings support the former, but not the latter interpretation.
authors.affiliation: Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, UK. d.gems@galton.ucl.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Gems
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D002467:Cell Nucleus / Q000378:metabolism; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D009154:Mutation; D010101:Oxygen Consumption / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin / Q000235:genetics
chemical_list: C104339:CLK-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D019869:Phosphatidylinositol 3-Kinases; C100662:AGE-1 protein, C elegans; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin