Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients.
OBJECTIVE
To assess the safety and potential efficacy of a mechanical ventilation strategy designed to reduce stretch-induced lung injury in acute respiratory distress syndrome.


METHODS
Prospective, randomized, controlled clinical trial.


METHODS
Eight intensive care units in four teaching hospitals.


METHODS
Fifty-two patients with acute respiratory distress syndrome.


METHODS
Traditional tidal volume patients: tidal volume 10-12 mL/kg ideal body weight, reduced if inspiratory plateau pressure was > 55 cm H2O (7.3 kPa). Small tidal volume patients: tidal volume 5-8 mL/kg ideal body weight, to keep plateau pressure < 30 cm H2O (4.0 kPa).


RESULTS
Mean tidal volumes during the first 5 days in traditional and small tidal volume patients were 10.2 and 7.3 mL/kg, respectively (p < .001), with mean plateau pressure = 30.6 and 24.9 cm H2O (3.3 kPa), respectively (p < .001). There were no significant differences in requirements for positive end-expiratory pressure or FIO2, fluid intakes/outputs, requirements for vasopressors, sedatives, or neuromuscular blocking agents, percentage of patients that achieved unassisted breathing, ventilator days, or mortality.


CONCLUSIONS
The reduced tidal volume strategy used in this study was safe. Failure to observe beneficial effects of small tidal volume ventilation treatment in important clinical outcome variables may have occurred because a) the sample size was too small to discern small treatment effects; b) the differences in tidal volumes and plateau pressures were modest; or c) reduced tidal volume ventilation is not beneficial.
Brower
R G
RG
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shanholtz
C B
CB
Fessler
H E
HE
Shade
D M
DM
White
P
P
Wiener
C M
CM
Teeter
J G
JG
Dodd-o
J M
JM
Almog
Y
Y
Piantadosi
S
S
D000328:Adult; D001784:Blood Gas Analysis; D001835:Body Weight; D002985:Clinical Protocols; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013990:Tidal Volume
D010100:Oxygen