title: Efficacy of pefloxacin in acute gonococcal urethritis.
abstract: A clinical trial of pefloxacin as a single oral regimen in the treatment of acute uncomplicated gonococcal infection was evaluated in sixty-four male patients with clinical and laboratory diagnosis of gonococcal urethritis using a single dose of 800 mg pefloxacin. Of the 64 men, 59 (92.2%) were infected by (penicillinase producing Neisseria gonorrhoeae (PPNG) strains, while 5 (7.8%) had non-PPNG strains. The cumulative percentage cure for all infections was 84.4%. Pefloxacin is effective as a single dose therapy for acute gonococcal urethritis in males infected by penicillinase producing and non-penicillinase producing Neisseria gonorrhea in our area of study.
authors.affiliation: Special Treatment Clinic, University College Hospital, Ibadan, Nigeria.
authors.forename: R A
authors.initials: RA
authors.lastname: Bakare
authors.forename: A A
authors.initials: AA
authors.lastname: Oni
authors.forename: A O
authors.initials: AO
authors.lastname: Arowojolu
authors.forename: A O
authors.initials: AO
authors.lastname: Okesola
authors.forename: T T
authors.initials: TT
authors.lastname: Ayuba
authors.forename: A O
authors.initials: AO
authors.lastname: Kehinde
authors.forename: T
authors.initials: T
authors.lastname: Shomuyiwa
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009549:Nigeria; D015366:Pefloxacin / Q000627:therapeutic use*; D010405:Penicillinase; D016896:Treatment Outcome; D014526:Urethritis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000892:Anti-Infective Agents, Urinary; D015366:Pefloxacin; D010405:Penicillinase