Synthesis and biophysical studies of modified oligonucleotides containing acyclic amino alcohol nucleoside analogs.
Novel serine derivative of thymine was prepared and incorporated into oligonucleotides. These modified oligonucleotides were studied for their binding affinity with complementary DNA/RNA.
Ramasamy
K S
KS
Research Division, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.
Stoisavljevic
V
V
D004247:DNA / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D012313:RNA / Q000737:chemistry
D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D012313:RNA; D004247:DNA; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I