Development and organization of the hypophysiotropic hypothalamus driving the pituitary-gonadal axis in the rhesus monkey.
The purpose of the present review is to describe, with particular emphasis on the rhesus monkey, the ontogeny and functional organisation of the hypothalamic GnRH pulse generator. Control of pituitary-gonadal axis in higher primates is provided by a group of some 1,000 GnRH neurons that are diffusely distributed throughout the hypothalamus. After synthesis of a prehormone and formation of the mature decapeptide, GnRH is released in the hypophysial portal circulation and stimulates FSH and LH production.
Plant
T M
TM
Department of Cell Biology and Physiology, University of Pittsburgh School of Medecine, USA.
el Majdoubi
M
M
Durrant
A R
AR
Sahu
A
A
D000375:Aging; D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006066:Gonads / Q000502:physiology*; D007031:Hypothalamus / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D008253:Macaca mulatta / Q000196:embryology / Q000254:growth & development*; D010507:Periodicity; D010902:Pituitary Gland / Q000502:physiology*
D007987:Gonadotropin-Releasing Hormone