title: Successful treatment of refractory supraventricular tachycardia by repeat intravascular injection of amiodarone in a fetus with hydrops.
abstract: We report the case of a fetus with supraventricular tachycardia complicated by congestive heart failure and ascites. After failure of initial transplacental treatment, the injection of amiodarone into the umbilical vein combined with evacuation of ascites achieved conversion to sinus rhythm and restored cardiac function thus allowing pregnancy to go to term. This report suggests that direct fetal therapy by umbilical vein puncture and evacuation of effusions constitutes an effective treatment for supraventricular tachycardias with massive fetal hydrops which do not respond to transplacental treatment.
authors.affiliation: Centre de Diagnostic Anténatal, Maternité-Hôpital, CHU Bordeaux, France.
authors.forename: R
authors.initials: R
authors.lastname: Mangione
authors.forename: F
authors.initials: F
authors.lastname: Guyon
authors.forename: A
authors.initials: A
authors.lastname: Vergnaud
authors.forename: M
authors.initials: M
authors.lastname: Jimenez
authors.forename: R
authors.initials: R
authors.lastname: Saura
authors.forename: J
authors.initials: J
authors.lastname: Horovitz
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000008:administration & dosage* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004077:Digoxin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006340:Heart Rate, Fetal; D006801:Humans; D015160:Hydrops Fetalis / Q000150:complications*; D007275:Injections, Intravenous; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000150:complications / Q000188:drug therapy*; D014471:Umbilical Veins
chemical_list: D000889:Anti-Arrhythmia Agents; D004077:Digoxin; D000638:Amiodarone