Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets.
The effect of dietary taurine on endogenous hypercholesterolemia induced by a phenobarbital-containing diet was investigated. Supplemented taurine did not affect the concentrations of serum cholesterol, but further potentiated the accumulation of hepatic cholesterol in the hypercholesterolemic state induced by phenobarbital. It is suggested that taurine might amplify the hepatic cholesterogenesis in phenobarbital-induced hypercholesterolemia.
Mochizuki
H
H
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Takido
J
J
Yokogoshi
H
H
D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004032:Diet; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000737:chemistry; D006937:Hypercholesterolemia / Q000097:blood* / Q000139:chemically induced*; D006993:Hypnotics and Sedatives; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010634:Phenobarbital; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*
D001647:Bile Acids and Salts; D006993:Hypnotics and Sedatives; D013654:Taurine; D002784:Cholesterol; D010634:Phenobarbital