title: Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease.
abstract: As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.
authors.affiliation: Department of Neurological Sciences, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Kordower
authors.forename: S
authors.initials: S
authors.lastname: Palfi
authors.forename: E Y
authors.initials: EY
authors.lastname: Chen
authors.forename: S Y
authors.initials: SY
authors.lastname: Ma
authors.forename: T
authors.initials: T
authors.lastname: Sendera
authors.forename: E J
authors.initials: EJ
authors.lastname: Cochran
authors.forename: E J
authors.initials: EJ
authors.lastname: Cochran
authors.forename: E J
authors.initials: EJ
authors.lastname: Mufson
authors.forename: R
authors.initials: R
authors.lastname: Penn
authors.forename: C G
authors.initials: CG
authors.lastname: Goetz
authors.forename: C D
authors.initials: CD
authors.lastname: Comella
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D007124:Immunoenzyme Techniques; D007276:Injections, Intraventricular; D008297:Male; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000008:administration & dosage*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000473:pathology
chemical_list: C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents