Effect of an alpha(2) agonist (mivazerol) on limiting myocardial ischaemia in stable angina.
A specific alpha(2) agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.
Fox
K
K
Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, UK.
Dargie
H J
HJ
de Bono
D P
DP
Oliver
M F
MF
Wülfert
E
E
Kharkevitch
T
T
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; C087969:mivazerol