Metal chelators/antioxidants: approaches to protect erythrocytic oxidative stress injury during Plasmodium berghei infection in Mastomys coucha.
Desferal, N-acetyl penicillamine (metal chelators) and propylgallate, catechin, and reduced glutathione (antioxidants) suppressed the erythrocytic oxidative damage generated during Plasmodium berghei infection in Mastomys coucha. Superoxide anion and lipid peroxide levels were increased and on the contrary, superoxide dismutase activity was noticeably decreased in the infected erythrocytes. Metal chelators/antioxidant treatment to infected animals resulted in restoration of O(2)(-), LPO and SOD to near normal levels. Furthermore, treatment of the above mentioned agents displayed a controlled mortality/survival time and parasitaemia. In conclusion, metal chelators/antioxidants were found to be effective against oxidative stress injury and parasite growth resulting in prolonged survival time of the host during experimental malaria.
Srivastava
P J
PJ
Department of Biochemistry, Central Drug Research Institute, Lucknow-1, India.
Chandra
S
S
Arif
A J
AJ
Singh
C
C
Panday
V
V
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology*; D003676:Deferoxamine / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008288:Malaria / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D009115:Muridae / Q000097:blood / Q000469:parasitology*; D018384:Oxidative Stress / Q000187:drug effects*; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D010962:Plasmodium berghei; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D013481:Superoxides / Q000097:blood
D000975:Antioxidants; D002614:Chelating Agents; D013481:Superoxides; C010005:N-acetylpenicillamine; D002392:Catechin; D013482:Superoxide Dismutase; D005978:Glutathione; D010396:Penicillamine; D003676:Deferoxamine