title: The Gregorio Marañón Hospital experience with vertical partial laryngectomies.
abstract: We present a retrospective study of 551 patients treated with conservative surgery for glottic carcinoma at the Gregorio Marañón Hospital between 1962 and 1996. In all, 12% of cases were locally advanced carcinomas. In early-stage carcinomas there were no statistical differences in 5-year survival between those treated by endoscopic laser resection, vertical hemilaryngectomy and radiotherapy. However, tumor recurrence after primary radiotherapy was higher (27%) than with conservative surgery (12%), while the voice preservation rate was significantly higher with surgery (83%) than with radiotherapy (72%). With locally advanced cancer, irradiated patients (to 60 Gy) had a 50% probability of recurrence with a very low chance for salvage by total laryngectomy (5-year survival rate, 38.5%). In contrast, partial laryngectomy could be performed on carefully selected patients, and the results for these patients were comparable to those for smaller lesions (with a 5-year survival rate of 81%).
authors.affiliation: ENT Department, Gregorio Marañón Hospital, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Scola
authors.forename: M
authors.initials: M
authors.lastname: Fernández-Vega
authors.forename: T
authors.initials: T
authors.lastname: Martinez
authors.forename: E
authors.initials: E
authors.lastname: Scola
authors.forename: S
authors.initials: S
authors.lastname: Fernández-Vega
authors.forename: C
authors.initials: C
authors.lastname: Ramírez
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D004724:Endoscopy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016879:Salvage Therapy; D013030:Spain; D015996:Survival Rate; D016896:Treatment Outcome