title: The response of distant uninvolved psoriatic skin to standardised injury is not different from that in normal skin.
abstract: The epidermis of uninvolved psoriatic skin is characterised by a slight hyperproliferation and an increase in inflammatory parameters, whereas no differentiation abnormalities are seen. Data with respect to the response of distant uninvolved psoriatic skin to standardised injury are not uniform. In this study, a recently developed multiparameter flow cytometric assay was used to compare the response to tape stripping of uninvolved psoriatic and normal skin. With this method, a parameter for proliferation, differentiation and inflammation was measured simultaneously. Concerning these parameters, no statistically significant differences were found between uninvolved psoriatic skin and normal skin. The mechanism that underlies hyperproliferation in distant uninvolved psoriatic skin does not indicate an intrinsic abnormality in keratinocytes. Inflammatory signals might play a role in this process.
authors.affiliation: Department of Dermatology, University Hospital Nijmegen, The Netherlands. m.vanrossum@derma.azn.nl
authors.forename: M M
authors.initials: MM
authors.lastname: van Rossum
authors.forename: J M
authors.initials: JM
authors.lastname: Mommers
authors.forename: C A
authors.initials: CA
authors.lastname: van Hooijdonk
authors.forename: P E
authors.initials: PE
authors.lastname: van Erp
authors.forename: P C
authors.initials: PC
authors.lastname: van de Kerkhof
mesh_terms: D002452:Cell Count; D002454:Cell Differentiation / Q000502:physiology; D002469:Cell Separation; D005434:Flow Cytometry; D006801:Humans; D008938:Mitosis / Q000187:drug effects; D011565:Psoriasis / Q000473:pathology*; D012867:Skin / Q000293:injuries* / Q000473:pathology*; D014746:Vimentin / Q000494:pharmacology
chemical_list: D014746:Vimentin