title: Role of local cytokines in increased gastric expression of the secretory component in Helicobacter pylori infection.
abstract: Using immunohistochemical staining, we examined the presence of secretory component (SC) on epithelial cells in gastric and duodenal biopsy specimens collected from Helicobacter pylori-infected individuals and healthy controls. Gastric epithelial cells from healthy volunteers expressed low, but detectable, levels of SC. In contrast, significantly higher level of expression of SC (P < 0.001) was observed on epithelial cells in the antra of H. pylori-infected individuals. The antral SC expression correlated with staining for gamma interferon of intraepithelial and lamina propria lymphocytes (r(s) = 0.76 and 0.69, respectively, P < 0.001) and correlated weakly with production of tumor necrosis factor alpha (r(s) = 0.43, P < 0.05), but it did not correlate at all with interleukin-4 production.
authors.affiliation: Departments of Medical Microbiology and Immunology, Göteborg University, Göteborg, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Ahlstedt
authors.forename: C
authors.initials: C
authors.lastname: Lindholm
authors.forename: H
authors.initials: H
authors.lastname: Lönroth
authors.forename: A
authors.initials: A
authors.lastname: Hamlet
authors.forename: A M
authors.initials: AM
authors.lastname: Svennerholm
authors.forename: M
authors.initials: M
authors.lastname: Quiding-Järbrink
mesh_terms: D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology*; D015847:Interleukin-4 / Q000096:biosynthesis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012635:Secretory Component / Q000096:biosynthesis*; D013270:Stomach / Q000276:immunology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology*
chemical_list: D007071:Immunoglobulin A, Secretory; D012635:Secretory Component; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007371:Interferon-gamma