Effect of calcitonin on bone healing following titanium implant insertion.
The purpose of this study was to evaluate the effects of calcitonin administration on bone healing, following titanium implant insertion. Thirty adult New Zealand rabbits received one implant in each femur. Fifteen animals were randomized to provide test (calcitonin) and control (saline solution) groups. The animals were sacrificed 7, 14, 21, 28 and 42 days after the surgical procedure. The analyzed parameters were new endosteal/periosteal bone length, new endosteal/periosteal bone area and total cortical length. Considering treatment, histometric measurements showed significant differences (p < 0.05) favoring the control group considering periosteal bone length and periosteal bone area, the other parameters were statistically similar between control and test groups.
Nociti
F H
FH
Department of Prosthesis and Periodontology, University of Campinas, Piracicaba S.P., Brazil.
Sallum
E A
EA
Toledo
S
S
Newman
H N
HN
Sallum
A W
AW
D000704:Analysis of Variance; D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002116:Calcitonin / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous / Q000706:statistics & numerical data; D004353:Drug Evaluation, Preclinical; D009336:Necrosis; D016348:Osseointegration; D011817:Rabbits; D011897:Random Allocation; D013997:Time Factors; D014025:Titanium; D014945:Wound Healing / Q000187:drug effects*
D002116:Calcitonin; D014025:Titanium