Adhesins in Candida albicans.
The adherent properties of Candida albicans blastoconidia and germ tubes have long been appreciated, but little is known about the mechanisms responsible for adherence. Recently, three genes, ALA1, ALS1 and HWP1, encoding proteins with adherent properties and motifs consistent with linkage to the beta-1, 6-glucan of C. albicans cell walls have provided insight into the topology of protein adhesins. Hwp1, a developmentally regulated adhesin of germ tubes and hyphae, attaches to buccal epithelial cells by an unconventional, transglutaminase-mediated mechanism of adhesion.
Sundstrom
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Department of Medical Microbiology and Immunology, Ohio State University, Columbus, OH 43210-1239, USA. sundstrom.1@osu.edu
D000595:Amino Acid Sequence; D002176:Candida albicans / Q000235:genetics*; D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules; D005656:Fungal Proteins / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000235:genetics; D008969:Molecular Sequence Data
C109455:ALA1 protein, Candida albicans; C093538:ALS1 protein, Candida albicans; D015815:Cell Adhesion Molecules; D005656:Fungal Proteins; C118102:HWP1 protein, Candida albicans; D008562:Membrane Glycoproteins