title: A short and efficient synthesis of 4-[2,2-dimethyl-4(tol-4-yl)benzochrom-3-en-7-yl]benzoic acid - a potent retinoic acid receptor antagonist.
abstract: An efficient synthesis of a potent RAR antagonist is described starting from disubstituted beta-naphthol. The functional groups on 2 and 3 positions of the beta-naphthol 5 were elaborated into benzochromanone 8. The title compound was prepared by Suzuki coupling of the left and right hand pieces.
authors.affiliation: Department of Chemistry, Allergan Inc, Irvine CA 92623, USA.
authors.forename: V
authors.initials: V
authors.lastname: Vuligonda
authors.forename: R A
authors.initials: RA
authors.lastname: Chandraratna
mesh_terms: D001565:Benzoates / Q000138:chemical synthesis*; D001578:Benzopyrans / Q000138:chemical synthesis*; D018168:Receptors, Retinoic Acid / Q000037:antagonists & inhibitors*
chemical_list: C121652:4-(2,2-dimethyl-4-(tol-4-yl)benzochrom-3-en-7-yl)benzoic acid; D001565:Benzoates; D001578:Benzopyrans; D018168:Receptors, Retinoic Acid