On the inhibitory activities of a new boron compound and ultrasound against the mouse ascites tumour.
The inhibitory effects of a new boron compound, dihydroxy (oxybiguanido) boron (III) hydrochloride monohydrate (HB), and ultrasound (US) of a frequency 25 kHz on the growth of ascites tumour in female Swiss mice were studied by monitoring the survival, weight of tumour-associated material, tumour cell count, serum alkaline phosphatase activity and the haematological parameters of the treated animals. 5-Fluorouracil (5-FU), a well-known anticancer agent, was used as positive control. While HB exhibited a very significant antitumour action, US alone produced a small but significant inhibitory effect. The combination of US with HB or 5-FU produced an extra antitumour action as compared to the actions of these chemicals used singly. The mechanisms of action of the new boron compound (HB) and US are discussed.
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Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta, India.
Ghosh
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Bag
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Chatterjee
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D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001896:Boron Compounds / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood / Q000201:enzymology / Q000628:therapy*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004906:Erythrocyte Count / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006454:Hemoglobins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D015996:Survival Rate; D014464:Ultrasonic Therapy
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D001896:Boron Compounds; D006454:Hemoglobins; C121738:dihydroxy(oxybiguanido)boron (III); D000469:Alkaline Phosphatase; D005472:Fluorouracil