title: The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.
abstract: The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.
authors.affiliation: Columbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY 10032, USA.
authors.forename: W K
authors.initials: WK
authors.lastname: Chung
authors.forename: A
authors.initials: A
authors.lastname: Luke
authors.forename: R S
authors.initials: RS
authors.lastname: Cooper
authors.forename: C
authors.initials: C
authors.lastname: Rotini
authors.forename: A
authors.initials: A
authors.lastname: Vidal-Puig
authors.forename: M
authors.initials: M
authors.lastname: Rosenbaum
authors.forename: D
authors.initials: D
authors.lastname: Gordon
authors.forename: S M
authors.initials: SM
authors.lastname: Leal
authors.forename: S
authors.initials: S
authors.lastname: Caprio
authors.forename: R
authors.initials: R
authors.lastname: Goldsmith
authors.forename: A L
authors.initials: AL
authors.lastname: Andreu
authors.forename: C
authors.initials: C
authors.lastname: Bruno
authors.forename: S
authors.initials: S
authors.lastname: DiMauro
authors.forename: M
authors.initials: M
authors.lastname: Heo
authors.forename: W L
authors.initials: WL
authors.lastname: Lowe
authors.forename: B B
authors.initials: BB
authors.lastname: Lowell
authors.forename: D B
authors.initials: DB
authors.lastname: Allison
authors.forename: R L
authors.initials: RL
authors.lastname: Leibel
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D005091:Exons; D006706:Homeostasis; D006801:Humans; D007473:Ion Channels; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins; D009154:Mutation; D009765:Obesity / Q000235:genetics / Q000503:physiopathology; D000071247:Uncoupling Protein 3
chemical_list: D002352:Carrier Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3