[The pharmacological blockade of the cardiac and gastric enteric ganglia by a new parasympatholytic].
The blocking effects of a newly synthetized compound N-decyltropine bromide (IEM-1556), on pentagastrin-, carbachol- and histamine-induced gastric secretion in chronic dogs, on stress-induced changes in gastric mucosa in rats, on vagus-induced effect in heart and on arterial blood pressure in rats were studied. The effects were compared with those produced by hexamethonium, a conventional ganglionic blocking agent. IEM-1556 inhibited gastric secretion and acid output for a much longer time than hexamethonium did. It also effectively protected gastric mucosa against stress-induced erosions and hemorrhages. IEM-1556 much more effectively blocked the vagus-induced reduction of the heart rate than hexamethonium did, and, in contrast to latter, did not reduce the arterial blood pressure. The results suggest that IEM-1556 is a highly selective blocking agent for parasympathetic and enteric ganglia versus sympathetic ganglia.
Remizov
I M
IM
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Berehova
T V
TV
Hroĭsman
S D
SD
Kharchenko
M M
MM
Purnyn'
O E
OE
Skok
V I
VI
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005726:Ganglia, Parasympathetic / Q000187:drug effects* / Q000502:physiology; D005730:Ganglionic Blockers / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D018738:Hexamethonium / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013270:Stomach / Q000294:innervation*; D013276:Stomach Ulcer / Q000188:drug therapy; D014326:Tropanes / Q000494:pharmacology* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D005730:Ganglionic Blockers; C121316:N-decyltropine bromide; D010276:Parasympatholytics; D014326:Tropanes; D018738:Hexamethonium