Proton magnetization transfer of metabolites in human brain.
Off-resonance or pulsed on-resonance saturation pulses were used together with localized proton magnetic resonance spectroscopy in three brain regions of 20 healthy individuals. Statistically significant signal attenuations were observed for creatine-containing metabolites in posterior-parietal brain (12%), basal ganglia (18%), and cerebellum (15%). N-acetyl- and choline-containing metabolites were not significantly attenuated upon application of saturation pulses in either brain region. The findings are interpreted to reflect possible magnetization transfer between pools of creatine-containing metabolites with different molecular mobility. Magn Reson Med 42:417-420, 1999.
Meyerhoff
D J
DJ
Magnetic Resonance Unit, Department of Veterans Affairs Medical Center and Department of Radiology, University of California San Francisco, San Francisco, California, USA. djmey@itsa.ucsf.edu
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002794:Choline / Q000378:metabolism*; D003401:Creatine / Q000378:metabolism*; D003627:Data Interpretation, Statistical; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons
D011522:Protons; D001224:Aspartic Acid; D000431:Ethanol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline