title: Our experience on the association of a new physical and medical therapy in patients suffering from induratio penis plastica.
abstract: OBJECTIVE
  To check the efficiency of shock waves in the treatment of induratio penis plastica. The Minilith SL1, successfully used in orthopedic or salivary stones because of its lithotriptic power, can be used to break plaques in Peyronie's disease.
  
  
  METHODS
  A total of 130 patients affected with Peyronie's disease were entered into a prospective trial. Patients with completely calcified plaques as determined by ultrasound evaluation were excluded. We divided the patients into three treatment groups: (A) shock waves alone in 21 patients; (B) a combination of shock waves and verapamil (perilesional injection) in 36 patients, and (C) verapamil alone in 73 patients. First, we treated all groups A and B patients 3 times, 20 min each time, with a Minilith SL1, and then only the patients of the second group received a complete cycle of twelve injections of verapamil (10 mg) every 2 weeks for 6 months. The group of 73 patients (group C) treated during the previous 2 years with a medical therapy (only injection of verapamil) was used as a control group.
  
  
  RESULTS
  Ultrasound evaluation showed a reduction of plaque in 11/21 group A patients and 7/36 group B patients. The treatment was tolerated very well and only 11 petechiae in some patients were noticed after ESW treatment.
  
  
  CONCLUSIONS
  The therapeutic association of shock waves with verapamil injection is an effective nonoperative treatment for the stabilization of Peyronie's disease.
authors.affiliation: Department of Urology of Naples 'Federico II', Italy.
authors.forename: V
authors.initials: V
authors.lastname: Mirone
authors.forename: C
authors.initials: C
authors.lastname: Imbimbo
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: F
authors.initials: F
authors.lastname: Fusco
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000628:therapy; D019220:High-Energy Shock Waves / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010411:Penile Induration / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D014463:Ultrasonography; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D014700:Verapamil