title: Ferrous sulphate gel dosimetry and MRI for proton beam dose measurements.
abstract: Ferrous sulphate gel dosimetry has the potential for measurement of absorbed dose distributions in proton therapy. The chemical properties of the gel are altered according to the radiation dose and these changes can be evaluated in three dimensions using MRI. The purpose of this work was to investigate the properties of a ferrous gel used with clinical proton beams. The gel was irradiated with both monoenergetic and range-modulated proton beams. It was then evaluated using MRI. The depth dose by means of the 1/T1 distribution was studied and compared with data from a plane-parallel plate ionization chamber. 1/T1 was shown to be proportional to the dose at a mean proton energy of approximately 90 MeV. The dose response was no different from that obtained using photon beams. However, on normalization at the entrance, the relative 1/T1 at the Bragg peak was 15-20% lower than the corresponding ionization chamber data for the monoenergetic proton beam. Better agreement was found for the modulated beam, but with significant differences close to the distal edge of the 1/T1 distribution. The change in sensitivity with depth was explained by means of a linear energy transfer dependence. This property was further studied using Monte Carlo methods.
authors.affiliation: Department of Radiation Physics, Malmö, Lund University, Malmö University Hospital, Sweden. sven.back@rfa.mas.lu.se
authors.forename: S A
authors.initials: SA
authors.lastname: Bäck
authors.forename: J
authors.initials: J
authors.lastname: Medin
authors.forename: P
authors.initials: P
authors.lastname: Magnusson
authors.forename: P
authors.initials: P
authors.lastname: Olsson
authors.forename: E
authors.initials: E
authors.lastname: Grusell
authors.forename: L E
authors.initials: LE
authors.lastname: Olsson
mesh_terms: D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D005296:Ferrous Compounds / Q000528:radiation effects*; D005782:Gels / Q000528:radiation effects; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011522:Protons; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012680:Sensitivity and Specificity
chemical_list: D005296:Ferrous Compounds; D005782:Gels; D011522:Protons; C020748:ferrous sulfate