title: In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies.
abstract: With the dopaminergic presynaptic ligand FP-CIT and single photon emission tomography we have shown a severe dopaminergic degeneration in a patient with a necropsy confirmed diagnosis of dementia with Lewy bodies (DLB). We suggest that functional imaging of the nigrostriatal dopamine pathway helps to distinguish DLB from Alzheimer's disease during life.
authors.forename: Z
authors.initials: Z
authors.lastname: Walker
authors.forename: D C
authors.initials: DC
authors.lastname: Costa
authors.forename: P
authors.initials: P
authors.lastname: Ince
authors.forename: I G
authors.initials: IG
authors.lastname: McKeith
authors.forename: C L
authors.initials: CL
authors.lastname: Katona
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003704:Dementia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D008297:Male; D009410:Nerve Degeneration; D009474:Neurons / Q000378:metabolism; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes
chemical_list: D019275:Radiopharmaceuticals; D014326:Tropanes; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; D004298:Dopamine