Treatment of pyoderma faciale with isotretinoin in a patient with ulcerative colitis.
The explosive onset of fluctuant facial papulonodules, usually in young women, is characteristic of pyoderma faciale. This disorder is neither a true pyoderma nor a variant of acne, but rather a severe form of rosacea. The most effective therapeutic modality appears to be isotretinoin, especially if preceded by a brief course of oral corticosteroids or a short interval of application of potent topical corticosteroids. Despite our concern about the potential adverse effects of systemic retinoids on underlying inflammatory bowel disease, isotretinoin was given to a patient with refractory pyoderma faciale. Response was dramatic, and no ill effects were encountered.
Rosen
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Baylor College of Medicine, Houston, Texas, USA.
Unkefer
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D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D005148:Facial Dermatoses / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D011711:Pyoderma / Q000150:complications / Q000188:drug therapy*; D012393:Rosacea / Q000150:complications / Q000188:drug therapy*; D009626:Terminology as Topic
D007641:Keratolytic Agents; D015474:Isotretinoin