title: The effects of acutely administered low dose sarin on cognitive behaviour and the electroencephalogram in the common marmoset.
abstract: Previous studies have suggested that administration of a clinically sign-free dose of sarin to non-human primates gives rise to subtle changes in brain electrical activity as measured by electroencephalography (EEG) several months following exposure. The functional significances of such changes are unclear. The present study monitored EEG by using implantable radiotelemetry, and also assessed the performance of complex behavioural tasks, in non-human primates for up to 15 months following exposure to a low dose of sarin. Baselines of EEG and behaviour were shown to be stable over several months in control animals. The doses of sarin administered caused erythrocyte cholinesterase inhibitions of 36.4% to 67.1%. Overall, no significant changes in EEG patterns were observed although there were increases in beta 2 amplitude which approached significance (p=0.07). No deleterious effects on performance were seen on the touchscreen mediated discrimination tasks presented from the Cambridge Neuropsychological Test Automated Battery (CANTAB). This study illustrates the validity of the approach employed and makes an important contribution to the investigation of the long-term effects of organophosphorous compounds.
authors.affiliation: Biomedical Sciences Department, CBD Porton Down, Salisbury, Wiltshire, UK. cbmdc@dera.gov.uk
authors.forename: P C
authors.initials: PC
authors.lastname: Pearce
authors.forename: H S
authors.initials: HS
authors.lastname: Crofts
authors.forename: N G
authors.initials: NG
authors.lastname: Muggleton
authors.forename: D
authors.initials: D
authors.lastname: Ridout
authors.forename: E A
authors.initials: EA
authors.lastname: Scott
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002144:Callithrix; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003071:Cognition / Q000187:drug effects*; D003210:Concept Formation / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D005625:Frontal Lobe / Q000187:drug effects; D010364:Pattern Recognition, Visual / Q000187:drug effects; D012193:Reversal Learning / Q000187:drug effects; D012524:Sarin / Q000633:toxicity*; D013686:Telemetry
chemical_list: D002800:Cholinesterase Inhibitors; D012524:Sarin; D000110:Acetylcholinesterase