Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53.
Homozygous arginine at codon 72 (HA72) of p53 was found in 22% of normal cervices and 30.0% of cervical cancers and no significant difference was detected between normal and cervical cancer with or without HPV 16/18. There was no correlation between HA72 and risk of cervical cancer in Chinese.
Ngan
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HY
Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong.
Liu
V W
VW
Liu
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SS
D001120:Arginine; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D016158:Genes, p53; D006720:Homozygote; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D027383:Papillomaviridae / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012307:Risk Factors; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000821:virology
D016159:Tumor Suppressor Protein p53; D001120:Arginine