[The suppression of c-fos protein expression in the islands of Calleja in damage to the mesostriatal dopaminergic system of the brain].
We found activation c-fos protein in the NO synthase-containing neurons within the islands of Calleja (96.46 +/- 16.03 fos-immunoreactive nuclei per 50 mm section) in control and suppression of this activation after unilateral 6-hydroxydopamine lesions of dopaminergic mesostriatal system of brain (14.31 +/- 4.59 nuclei per section). Since the neuronal activity in the islands of Calleja is associated with the blood supply changes in the basal ganglia we propose that the suppression of c-fos protein expression in this structure after lesions of dopaminergic mesostriatal system reflects the disorders its blood supply.
Shapoval
M V
MV
A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
D000818:Animals; D003864:Depression, Chemical; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology; D009833:Olfactory Pathways / Q000187:drug effects / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*
D009498:Neurotoxins; D020030:Nitric Oxide Donors; D016760:Proto-Oncogene Proteins c-fos; D011954:Receptors, Dopamine; D016627:Oxidopamine; D019001:Nitric Oxide Synthase; D005996:Nitroglycerin