Design of peptides derived from anti-IgE antibody for allergic treatment.
We have designed and synthesized peptides derived from an anti-IgE antibody which has a potential for the treatment of allergy. It was indicated that conformational restriction of peptide via an intramolecular disulfide bond improved the binding affinity for IgE and that the peptide might have an ability to inhibit the IgE-receptor interaction.
Takahashi
M
M
Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
Ohgitani
Y
Y
Ueno
A
A
Mihara
H
H
D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D017455:Receptors, IgE / Q000037:antagonists & inhibitors
D018926:Anti-Allergic Agents; D000888:Antibodies, Anti-Idiotypic; D007135:Immunoglobulin Variable Region; D010455:Peptides; D017455:Receptors, IgE; C026408:anti-IgE antibodies; D007073:Immunoglobulin E