title: Interstitial high dose rate brachytherapy in locally progressive or recurrent head and neck cancer.
abstract: In a retrospective study, 19 patients with progressive or recurrent head and neck cancer which had been treated with interstitial high dose rate brachytherapy were analysed. All of them had been previously treated with external radiation. Initial therapy further included surgery in 9 cases and chemotherapy in 3 patients. Staging according to the TNM system revealed advanced stage tumors in the majority of patients. Interstitial brachytherapy was carried out with the isotope Iridium-192. The applied total dose at the reference isodose varied between 10 and 30 Gy. Application was fractionated once a week. A complete tumor remission was achieved in 5 patients and partial remission in 10 patients. In 4 patients the tumor continued to grow despite brachytherapy. The mean follow-up in our collective was 21 months. The calculated local control rate was 34% at 24 months. The survival rate was 49% at 12 months and 35% at 24 months. Interstitial brachytherapy is recommended as a palliative treatment in preirradiated squamous cell carcinoma with local recurrence or progression.
authors.affiliation: Abteilung für Strahlentherapie und Radioonkologie, Universitätskrankenhaus Hamburg-Eppendorf, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Krüll
authors.forename: R E
authors.initials: RE
authors.lastname: Friedrich
authors.forename: R
authors.initials: R
authors.lastname: Schwarz
authors.forename: H
authors.initials: H
authors.lastname: Thurmann
authors.forename: R
authors.initials: R
authors.lastname: Schmelzle
authors.forename: W
authors.initials: W
authors.lastname: Alberti
mesh_terms: D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D018450:Disease Progression; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D010166:Palliative Care; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis