title: Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development.
abstract: The members of the T-box gene family share a highly conserved DNA binding domain named the T-domain, and important developmental functions. Here we report the cloning of chicken Tbr1 and of murine and chicken Tbr2 (orthologs of the Xenopus eomesodermin gene), the mapping of the murine Tbr2 to chromosome 9, and their pattern of expression during mouse and chick embryogenesis. Both Tbr 1 and 2 have a restricted and conserved domain of expression in the telencephalic pallium of the two species. Chick Tbr2 has a specific and dynamic expression in the gastrulating embryo.
authors.affiliation: Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy. bulfone@tigem.it
authors.forename: A
authors.initials: A
authors.lastname: Bulfone
authors.forename: S
authors.initials: S
authors.lastname: Martinez
authors.forename: V
authors.initials: V
authors.lastname: Marigo
authors.forename: M
authors.initials: M
authors.lastname: Campanella
authors.forename: A
authors.initials: A
authors.lastname: Basile
authors.forename: N
authors.initials: N
authors.lastname: Quaderi
authors.forename: C
authors.initials: C
authors.lastname: Gattuso
authors.forename: J L
authors.initials: JL
authors.lastname: Rubenstein
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D002642:Chick Embryo; D002645:Chickens; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D017386:Sequence Homology, Amino Acid; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C491198:Eomes protein, mouse; D009419:Nerve Tissue Proteins; D020825:T-Box Domain Proteins; C492271:Tbr1 protein, mouse; D014157:Transcription Factors