[The determination of the cellular immunity indices in papillomavirus infection of the female genitalia].
The authors studied the impact of HPV infection and HPV-associated cellular intraepithelial neoplasia (CIN) and cancer in situ on indicators of cellular immunity, such as levels of T(CD3+)- and B (CD19+)-lymphocytes as well as those of their subpopulations (CD4+, CD8+, CD3+DR+, CD3-DR+). Female patients presenting with benign states and CIN II as well as those with CIN III and cancer in situ induced by HPV exhibit an apparent decrease in CD3+DR+T-lymphocyte count in their peripheral blood. In benign states and CIN I as well as in CIN III an cancer in situ levels of CD4(+)-cells are noted to be on the decrease while those of CD8+ T-lymphocytes get appreciably increased. Female patients with benign states and CIN I as well as those with CIN III and cancer in situ have a reduction in the index CD4/CD8 compared to the values in controls. The results obtained may have a prognostic significance and will, we believe, help in developing methodological approaches to the immunocorrection of HPV infections and HPV-associated disorders of female genital organs.
Lakatosh
V P
VP
Lazarenko
L M
LM
Spivak
M Ia
MIa
Lianenko
L O
LO
Azarskova
M V
MV
Mikhaĭlenko
O M
OM
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D002278:Carcinoma in Situ / Q000276:immunology; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D018655:Lymphocyte Count; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000276:immunology