title: [Liver transplantation with a living related donor in the child].
abstract: OBJECTIVE
  Liver transplantation with living related donor has been recently developed to compensate for the insufficient number of liver grafts for children. The major problem is ethical because it implies voluntary mutilation of a healthy person. This paper report results in 37 living related donors.
  
  
  METHODS
  Recipients were followed in Enfants-Malades Hospital. Investigations and donor surgery were performed at the Digestive Surgery Unit of Beaujon Hospital.
  
  
  RESULTS
  One donor was re-operated for bleeding, and another one a biliary fistula treated with percutaneous drainage for one week. The post-operative course was uneventful in the other donors, with a follow-up of between 2 and 50 months. Thirty-three children are alive (90%), one of them underwent a second transplant for arterial thrombosis. Vascular and infectious complications, and the number of rejection episodes were the same as in transplantations with a deceased donor. Biliary complications were frequent (15 patients out of 37) and significantly increased morbidity. A teenage boy who received a small graft (0.9% of his weight) presented initially with hepatic insufficiency without encephalopathy.
  
  
  CONCLUSIONS
  This technique has been shown to have a good balance between benefits and risks. Our experience confirms this, especially in very young children. Each case should be discussed individually and parental consent should be obtained without external pressure. Experience with this technique should be continued and at the same time the use of cadaveric grafts should be optimized.
authors.affiliation: Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Lacaille
authors.forename: J
authors.initials: J
authors.lastname: Belghiti
authors.forename: F
authors.initials: F
authors.lastname: Sauvat
authors.forename: J L
authors.initials: JL
authors.lastname: Michel
authors.forename: O
authors.initials: O
authors.lastname: Farges
authors.forename: A
authors.initials: A
authors.lastname: Rengeval
authors.forename: S
authors.initials: S
authors.lastname: Sarnacki
authors.forename: N
authors.initials: N
authors.lastname: Sayegh
authors.forename: D
authors.initials: D
authors.lastname: Jan
authors.forename: Y
authors.initials: Y
authors.lastname: Revillon
mesh_terms: D000293:Adolescent; D001660:Biliary Tract Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005190:Family; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D007239:Infections; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D011183:Postoperative Complications; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000209:etiology