title: Multi-organellar disorders of pigmentation: intracellular traffic jams in mammals, flies and yeast.
abstract: Several different mutant genes in humans, mice and Drosophila, most of which were identified initially on the basis of reduced pigmentation, have been associated with defects of multiple cytoplasmic organelles - melanosomes, lysosomes and granules. Recent discoveries show that several of these mutations directly affect components in the pathway of organelle-specific protein trafficking, and provide new insights into the relationships of these pathways in mammals, flies and yeast.
authors.affiliation: Human Medical Genetics Program, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B161, Denver, CO 80262, USA. richard.spritz@uchsc.edu
authors.forename: R A
authors.initials: RA
authors.lastname: Spritz
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D009154:Mutation; D015388:Organelles / Q000378:metabolism; D010859:Pigmentation Disorders / Q000235:genetics* / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins