Molecular regulation of cell death and therapeutic strategies for cell death induction in prostate carcinoma.
Many of the common molecular alterations associated with prostate cancer progression involve genes known to regulate cell death susceptibility. The significance of these molecular events is discussed in the context of developing and implementing new strategies designed to restore cell death susceptibility in prostate cancer cells and overcome therapeutic resistance.
Gjertsen
B T
BT
Department of Molecular Pathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Logothetis
C J
CJ
McDonnell
T J
TJ
D017209:Apoptosis; D016923:Cell Death / Q000235:genetics / Q000502:physiology*; D015316:Genetic Therapy; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D051028:bcl-2-Associated X Protein
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein