Glomerulonephritis without IgA deposits in a case of Henoch-Schönlein purpura.
A boy aged 3 years 8 months with Henoch-Schönlein purpura (HSP) developed significant proteinuria with hematuria 2 days after the appearance of purpura rash. Although thought to be purpura nephritis, a percutaneous renal biopsy revealed diffuse mesangial proliferative glomerulonephritis (MesPGN) without deposition of immunoglobulin A or complement. Since his urine screening test during a health check at the age of 3.5 years had been unremarkable, HSP might have played a role in the pathogenesis of his non-IgA MesPGN. To our knowledge, non-IgA MesPGN is an uncommon renal manifestation of HSP.
Tanaka
H
H
Division of Pediatrics, Iwate Prefectural Kitakami Hospital, Kitakami, Japan.
Onodera
N
N
Waga
S
S
Monma
N
N
D002675:Child, Preschool; D003165:Complement System Proteins / Q000378:metabolism; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000209:etiology*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D007070:Immunoglobulin A / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron
D007070:Immunoglobulin A; D003165:Complement System Proteins