[Volume-sensitive anion conductivity in a human prostatic carcinoma cell line].
For the first time membrane anion current activated in response to the cell swelling following exposure to hypotonic solution has been found in human prostate carcinoma cell line LNCaP. The development of hypotonicity-evoked current required 5 to 10 min to the maximum and was almost completely reversible upon return to the solution with normal osmolarity. Not absolute selectivity for Cl- ions of the respective cell volume-sensitive channels has been shown.
Shuba
Ia M
IaM
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine.
Skryma
R N
RN
Prevars'ka
N B
NB
D000230:Adenocarcinoma / Q000503:physiopathology*; D000838:Anions; D018118:Chloride Channels / Q000502:physiology; D003470:Culture Media; D004553:Electric Conductivity; D006801:Humans; D007038:Hypotonic Solutions; D008198:Lymph Nodes / Q000503:physiopathology*; D008207:Lymphatic Metastasis; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D018408:Patch-Clamp Techniques; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D014407:Tumor Cells, Cultured
D000838:Anions; D018118:Chloride Channels; D003470:Culture Media; D007038:Hypotonic Solutions