Biopharmaceutical production in transgenic livestock.
The production of recombinant human proteins in the milk of transgenic dairy animals offers a safe, renewable source of commercially important proteins that cannot be produced as efficiently in adequate quantities by other methods. A decade of success in expressing a variety of proteins in livestock has brought three human recombinant proteins to human clinical trials. Recent progress has drawn on molecular biology and reproductive physiology to improve the efficiency of producing and reproducing useful transgenic founder animals, and to improve the expression of heterologous proteins in their milk.
Rudolph
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D000818:Animals; D000829:Animals, Domestic / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D030801:Animals, Genetically Modified / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D001688:Biological Products / Q000096:biosynthesis*; D001709:Biotechnology / Q000379:methods*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008892:Milk; D053652:Nuclear Transfer Techniques; D011994:Recombinant Proteins / Q000096:biosynthesis*; D012099:Reproductive Techniques; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D019076:Transgenes / Q000235:genetics
D001688:Biological Products; D011994:Recombinant Proteins