Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).
A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.
Johnson
D A
DA
Pharmaceutical Discovery Division, Ribi ImmunoChem Research, Inc., Hamilton, MT 59840, USA.
Sowell
C G
CG
Johnson
C L
CL
Livesay
M T
MT
Keegan
D S
DS
Rhodes
M J
MJ
Ulrich
J T
JT
Ward
J R
JR
Cantrell
J L
JL
Brookshire
V G
VG
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D011817:Rabbits; D013329:Structure-Activity Relationship; D013403:Sugar Phosphates / Q000138:chemical synthesis* / Q000494:pharmacology; D013745:Tetanus Toxoid / Q000276:immunology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D013403:Sugar Phosphates; D013745:Tetanus Toxoid; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D005944:Glucosamine