title: Clinical investigation of atypical adenomatous hyperplasia of the lung.
abstract: The clinicopathologic characteristics of atypical adenomatous hyperplasia (AAH) remain unclear. A total of 137 patients underwent resection for adenocarcinoma of the lung at our institution. Examination of resected lung tissue showed that in addition to adenocarcinoma AAH was present in 26 cases and was not present in 111 cases. All nonsmokers with AAH (n = 13) had earlier-stage disease (stage IA, IB, IIA, and IIB) and no history of respiratory disease. Among patients with stage IA disease, the relapse-free and overall survival curves for those with AAH (n = 14) tended to be better than for those without AAH (n = 40), but the difference was not statistically significant (P = 0.056 and 0.087, respectively). Concurrent presence of AAH may be a favorable prognostic indicator in patients with stage IA adenocarcinoma.
authors.affiliation: Department of Internal Medicine, National Shikoku Cancer Center Hospital, Matsuyama, Japan. ntakigaw@shikoku-cc.go.jp
authors.forename: N
authors.initials: N
authors.lastname: Takigawa
authors.forename: Y
authors.initials: Y
authors.lastname: Segawa
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: H
authors.initials: H
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Mandai
authors.forename: D
authors.initials: D
authors.lastname: Kishino
authors.forename: M
authors.initials: M
authors.lastname: Shimono
authors.forename: M
authors.initials: M
authors.lastname: Ida
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000473:pathology; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects; D016019:Survival Analysis