title: The etiology and treatment of traumatic and septic shock.
abstract: Disseminated intravascular coagulation can cause multiple organ failure including adult respiratory distress syndrome by obstruction of visceral microcirculation by microclots. It was reasoned that if a clot causes vascular obstruction, lysing the clot by a plasminogen activator would be of value.
authors.affiliation: Department of Surgery, Texas Tech University Health Sciences Center, El Paso 79905, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Hardaway
mesh_terms: D000328:Adult; D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology / Q000517:prevention & control; D010960:Plasminogen Activators / Q000627:therapeutic use; D011175:Positive-Pressure Respiration; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000628:therapy; D012772:Shock, Septic / Q000209:etiology* / Q000628:therapy*; D012774:Shock, Traumatic / Q000209:etiology* / Q000628:therapy*; D013552:Swine; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator