Comparison study of combined DTPw-HB vaccines and separate administration of DTPw and HB vaccines in Thai children.
The safety, immunogenicity and tolerability of two different DTPw-HBV combination vaccines, containing 5 and 10 microg of HBsAg; were investigated in comparison with separate administration of DTPw and HBV (10 microg of HBsAg). A three dose primary vaccination course at 2, 4 and 6 months of age was followed by a booster dose at 18 months. All vaccines were safe and well tolerated. The DTPw-HBV combination vaccine containing 10 microg of HBsAg elicited significantly higher anti-HBs titres than the other two vaccines after the primary and booster vaccination course. All vaccines elicited a high response against the other components. Based on these results, DTPw-HBV (10 microg HBsAg) was the most effective vaccine at this schedule.
Poovorawan
Y
Y
Department of Paediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand.
Theamboonlers
A
A
Sanpavat
S
S
Chongsrisawat
V
V
Willems
P
P
Safary
A
A
D000917:Antibody Formation / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D004890:Erythema / Q000139:chemically induced; D005334:Fever / Q000139:chemically induced; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007223:Infant; D010146:Pain / Q000139:chemically induced; D012894:Sleep Stages / Q000187:drug effects; D013997:Time Factors; D014611:Vaccination; D017778:Vaccines, Combined
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined