title: Molecular remission in adult T cell leukemia after autologous CD34+ peripheral blood stem cell transplantation.
abstract: This report describes a patient with acute-type adult T cell leukemia/lymphoma (ATLL) successfully treated by autologous CD34+ peripheral blood stem cell transplantation after fractionated total body irradiation and high-dose cytarabine and cyclophosphamide. A newly established inverse polymerase chain reaction method was used to demonstrate the disappearance of ATLL clonal cells. The patient achieved a sustained molecular remission after transplantation, but died from opportunistic infection 4 months after transplantation. Thus, autologous CD34+ peripheral blood stem cell transplantation is promising for this type of malignancy. However, a prudent clinical attitude toward immunological fragility after transplantation is needed for better outcome.
authors.affiliation: Bone Marrow Transplantation Team, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakane
authors.forename: K
authors.initials: K
authors.lastname: Ohashi
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Moriya
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Tanikawa
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Karasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Okuyama
authors.forename: K
authors.initials: K
authors.lastname: Hiruma
authors.forename: H
authors.initials: H
authors.lastname: Sakamaki
mesh_terms: D018952:Antigens, CD34; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D014411:Neoplastic Stem Cells; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D014182:Transplantation, Autologous
chemical_list: D018952:Antigens, CD34