Gene therapy for osteoinduction.
One application of gene therapy that holds great promise is the stimulation of bone formation. Gene therapy offers several potential advantages over other methods of osteoinduction and current research suggests that it may be a feasible treatment option for the orthopedic surgeon in the near future. This article reviews the basic concepts and strategies of gene therapy and evaluates the current research using gene therapy to induce bone formation and enhance healing.
Scaduto
A A
AA
Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, California, USA.
Lieberman
J R
JR
D001854:Bone Marrow Cells / Q000166:cytology; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000235:genetics; D005240:Feasibility Studies; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D010012:Osteogenesis / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics; D014945:Wound Healing / Q000235:genetics
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta