Little contribution of GB virus C to the development of primary hepatocellular carcinoma in Japan.
RNA of GB virus C was searched for in sera from 109 patients with primary hepatocellular carcinoma. It was detected in 11 patients (10%), and was more frequent than in 3 of 342 blood donors (0.9%) (P < 0.001). The 11 patients included 4 of 29 patients (14%) with hepatitis B surface antigen and 7 of 74 patients (9%) with antibody to hepatitis C virus. RNA of GB virus C was not detected in any of 4 patients without hepatitis B surface antigen or antibody to hepatitis C virus. These results suggest that GB virus C may contribute little to the development of primary hepatocellular carcinoma in Japan.
Nishiyama
Y
Y
Second Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
Hino
K
K
Sawada
N
N
Tsuda
F
F
D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D018067:Flaviviridae / Q000302:isolation & purification*; D016174:Hepacivirus / Q000302:isolation & purification; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D018937:Hepatitis C Antibodies / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral