title: Influence of dietary n-3 polyunsaturated fatty acid on experimental tooth movement in rats.
abstract: This study was conducted to investigate the influence of dietary n-3 polyunsaturated fatty acid on experimental tooth movement. This acid substantially reduces the production of arachidonic acid. Sixty 4-week-old male Wistar strain rats were divided into experimental and control groups. Animals in the experimental group were fed a purified diet containing 10% refined fish oil (rich in n-3 fatty acid); control animals were fed a diet containing 10% corn oil (rich in n-6 fatty acid). After 6 weeks, the maxillary first molars were moved buccally with an initial force of 20 g for periods of 0, 3, 7, or 14 days. Tooth movement in the experimental group was 80% of that seen in the controls. The number of osteoclasts on the pressure side during tooth movement was nearly 60% of that seen in controls, and the degree of bone resorption was 80%. The data suggest that a diet enriched with fish oil reduces osteoclastic activity and subsequent alveolar bone resorption that is the key to experimental tooth movement.
authors.affiliation: Department of Orthodontics, Hiroshima University, School of Dentistry, Japan. yiwami@ipc.hiroshima-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Iwami-Morimoto
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Tanne
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000517:prevention & control*; D000539:Alveolar Process / Q000187:drug effects*; D000704:Analysis of Variance; D000821:Animal Feed; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects; D003799:Dental Stress Analysis; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D008297:Male; D010010:Osteoclasts / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques / Q000009:adverse effects
chemical_list: D015525:Fatty Acids, Omega-3