title: Is megalencephaly specific to autism?
abstract: Several recent reports have described the presence of increased head circumference (megalencephaly) in patients with autism. Although some studies have described reports of megalencephaly in other disorders such as schizophrenia in adults, few such studies have been performed in children and adolescents. In the present study, the authors compared 20 subjects with autism/ pervasive developmental disorder (DSM-IV; all males; mean age = 10.9 years) with 20 controls with attention deficit hyperactivity disorder (DSM-IV; all males; mean age = 11.1 years). Four subjects and five controls had evidence of megalencephaly. In addition to their core symptoms, the autistic subjects with megalencephaly were hyperactive and impulsive. These findings suggest that megalencephaly may not be specific to autism, and when present, it may index the presence of additional symptoms such as hyperactivity and impulsivity.
authors.affiliation: University of Michigan, Ann Arbor 48109-0390, USA. mghaziud@umich.edu
authors.forename: M
authors.initials: M
authors.lastname: Ghaziuddin
authors.forename: J
authors.initials: J
authors.lastname: Zaccagnini
authors.forename: L
authors.initials: L
authors.lastname: Tsai
authors.forename: S
authors.initials: S
authors.lastname: Elardo
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis; D001321:Autistic Disorder / Q000175:diagnosis*; D002508:Cephalometry; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis; D019465:Craniofacial Abnormalities / Q000175:diagnosis*; D006801:Humans; D007175:Impulsive Behavior / Q000175:diagnosis; D008297:Male; D012016:Reference Values