title: A multisubstrate adduct inhibitor of AICAR transformylase.
authors.affiliation: Department of Chemistry, 414 Wartik Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
authors.forename: M
authors.initials: M
authors.lastname: Wall
authors.forename: J H
authors.initials: JH
authors.lastname: Shim
authors.forename: S J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005453:Fluorescence; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D019877:Hydroxymethyl and Formyl Transferases / Q000037:antagonists & inhibitors*; D009097:Multienzyme Complexes / Q000378:metabolism; D009709:Nucleotide Deaminases / Q000378:metabolism; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D011485:Protein Binding; D011622:Pterins / Q000138:chemical synthesis / Q000494:pharmacology; D012265:Ribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D013379:Substrate Specificity
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; D011622:Pterins; D012265:Ribonucleotides; C121665:beta-DADF; D018698:Glutamic Acid; D019877:Hydroxymethyl and Formyl Transferases; D051027:Phosphoribosylaminoimidazolecarboxamide Formyltransferase; D009709:Nucleotide Deaminases; C021436:IMP cyclohydrolase