title: The TBP-like factor: an alternative transcription factor in metazoa?
abstract: Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms. Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes. Thus, the existence of TLFs presents a challenge to the doctrine that TBP is a universal regulator of transcription in metazoans.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, F-67404 Illkirch, Cedex, C.U. de Strasbourg, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Dantonel
authors.forename: J M
authors.initials: JM
authors.lastname: Wurtz
authors.forename: O
authors.initials: O
authors.lastname: Poch
authors.forename: D
authors.initials: D
authors.lastname: Moras
authors.forename: L
authors.initials: L
authors.lastname: Tora
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D017173:Caenorhabditis elegans / Q000737:chemistry; D017124:Conserved Sequence; D004257:DNA Polymerase II / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D016208:Databases, Factual; D019143:Evolution, Molecular; D007448:Invertebrates / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity; D035182:TATA Box Binding Protein-Like Proteins; D035181:TATA-Box Binding Protein; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014714:Vertebrates / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D035182:TATA Box Binding Protein-Like Proteins; D035181:TATA-Box Binding Protein; D014157:Transcription Factors; D004257:DNA Polymerase II