title: Applications of amorphous track models in radiation biology.
abstract: The average or amorphous track model uses the response of a system to gamma-rays and the radial distribution of dose about an ion's path to describe survival and other cellular endpoints from proton, heavy ion, and neutron irradiation. This model has been used for over 30 years to successfully fit many radiobiology data sets. We review several extensions of this approach that address objections to the original model, and consider applications of interest in radiobiology and space radiation risk assessment. In the light of present views of important cellular targets, the role of target size as manifested through the relative contributions from ion-kill (intra-track) and gamma-kill (inter-track) remains a critical question in understanding the success of the amorphous track model. Several variations of the amorphous model are discussed, including ones that consider the radial distribution of event-sizes rather than average electron dose, damage clusters rather than multiple targets, and a role for repair or damage processing.
authors.affiliation: NASA Johnson Space Center, Houston, TX 77058, USA. Fcucinot@ems.jsc.nasa.gov
authors.forename: F A
authors.initials: FA
authors.lastname: Cucinotta
authors.forename: H
authors.initials: H
authors.lastname: Nikjoo
authors.forename: D T
authors.initials: DT
authors.lastname: Goodhead
mesh_terms: D000818:Animals; D004247:DNA / Q000528:radiation effects; D004735:Energy Transfer; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D018499:Linear Energy Transfer; D016014:Linear Models; D008954:Models, Biological; D015233:Models, Statistical; D009154:Mutation; D011829:Radiation Dosage; D011853:Radiobiology / Q000295:instrumentation / Q000379:methods*; D018570:Risk Assessment
chemical_list: D004247:DNA