The paraxanthine:caffeine ratio in serum or in saliva as a measure of CYP1A2 activity: when should the sample be obtained?
Spigset
O
O
Division of Clinical Pharmacology, Norrland University Hospital, Umeå, Sweden. olav.spigset@relis.rit.no
Hägg
S
S
Söderström
E
E
Dahlqvist
R
R
D000328:Adult; D019540:Area Under Curve; D002110:Caffeine / Q000097:blood / Q000493:pharmacokinetics*; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D006801:Humans; D008297:Male; D012463:Saliva / Q000378:metabolism*; D013048:Specimen Handling / Q000379:methods*; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
D002110:Caffeine; D013806:Theophylline; D019388:Cytochrome P-450 CYP1A2; C021183:1,7-dimethylxanthine