Metabotropic glutamate receptors 2 and 3 expressed by astrocytes in rat ventrobasal thalamus.
It has been reported that pharmacologic activation of metabotropic receptors mGluR2/3 may produce inhibition of GABAergic transmission in rat ventrobasal thalamus. We use double immunolabeling to show that: (i) mGluR2/3 is expressed in glial processes surrounding GABAergic terminals, rather than in the terminals themselves, and (ii) mR2/3 positive glial lamellae more frequently surround GABAergic terminals and ascending terminals, than cortical terminals. This suggests involvement of glia in glutamate/GABA interactions in the sensory thalamus.
Mineff
E
E
Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, USA. minev@med.unc.edu
Valtschanoff
J
J
D000344:Afferent Pathways / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D013788:Thalamus / Q000166:cytology / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3; D005680:gamma-Aminobutyric Acid