title: Synthesis and biological evaluation of carbocyclic analogues of lipid X: new nonpolar antagonists of LPS induced TNF production.
abstract: We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for endotoxic shock.
authors.affiliation: Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France.
authors.forename: S
authors.initials: S
authors.lastname: Augy-Dorey
authors.forename: D C
authors.initials: DC
authors.lastname: Billington
authors.forename: J A
authors.initials: JA
authors.lastname: Camara
authors.forename: S D
authors.initials: SD
authors.lastname: Gero
authors.forename: I
authors.initials: I
authors.lastname: Sagnard
authors.forename: B
authors.initials: B
authors.lastname: Quiclet-Sire
authors.forename: D
authors.initials: D
authors.lastname: Ghezzi
mesh_terms: D000146:Acids, Carbocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004347:Drug Interactions; D006017:Glycolipids / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012772:Shock, Septic / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D000146:Acids, Carbocyclic; D006017:Glycolipids; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C044283:lipid X