title: Kojic acid--a new leading molecule for a preparation of compounds with an anti-neoplastic potential.
abstract: Kojic acid as a molecule of natural origin may serve as template for the synthesis of new biologically active compounds. The synthetic KA (pyranone) derivatives possess various kinds of biological activities which are related by their similarity to flavonoids. The most important property is the antifungal and antineoplastic activity and capability of chelating metals. It is shown that the antineoplastic activity of kojic acid derivatives is based on various mechanisms of action on different levels of cellular metabolism and functions what makes this compound interesting for future investigation as cytotoxic agent.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, Safat.
authors.forename: L
authors.initials: L
authors.lastname: Novotný
authors.forename: P
authors.initials: P
authors.lastname: Rauko
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Hamid
authors.forename: A
authors.initials: A
authors.lastname: Váchalková
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000188:drug therapy; D011753:Pyrones / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011753:Pyrones; C011890:kojic acid