title: Effects of permanent tracheostomy on respiratory reflexes to lung inflation and capsaicin in sevoflurane-anaesthetized dogs.
abstract: The aim of this study was to evaluate the effects of permanent tracheostomy on baseline breathing, reflex responses to lung hyperinflation (1.5 kPa) and right atrial capsaicin injection (5 micrograms/kg) before and at 3 and 5 weeks after tracheostomy in sevoflurane-anaesthetized spontaneously breathing dogs (n = 6). In all observation periods, apnoeic responses, represented by an increase in expiration time after lung inflation and right atrial capsaicin injection, were consistently observed to be a result of the Hering-Breuer inflation reflex and the pulmonary C-fibre chemoreflex. Investigation at 3 and 5 weeks after tracheostomy revealed no significant evidence of changing baseline breathing pattern or reflex responses to lung inflation and capsaicin in any ventilatory variable (inspiration time, expiration time, tidal volume, expired ventilation, and end-tidal PCO2) from levels recorded before surgery. These results indicate that permanent tracheostomy, at least up to 5 weeks, does not affect the baseline breathing pattern, the Hering-Breuer inflation reflex or the pulmonary C-fibre chemoreflex. Further, our investigation provides a useful canine model in respiratory physiology.
authors.affiliation: Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan. tmutoh@ucdavis.edu
authors.forename: T
authors.initials: T
authors.lastname: Mutoh
authors.forename: A
authors.initials: A
authors.lastname: Kanamaru
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Tsubone
mesh_terms: D018685:Anesthetics, Inhalation; D000818:Animals; D001049:Apnea / Q000662:veterinary; D002211:Capsaicin / Q000494:pharmacology; D004285:Dogs / Q000502:physiology* / Q000601:surgery; D005260:Female; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008738:Methyl Ethers; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane; D014139:Tracheostomy / Q000379:methods / Q000662:veterinary*
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D002211:Capsaicin