title: Pearling in cells: a clue to understanding cell shape.
abstract: Gradual disruption of the actin cytoskeleton induces a series of structural shape changes in cells leading to a transformation of cylindrical cell extensions into a periodic chain of "pearls." Quantitative measurements of the pearling instability give a square-root behavior for the wavelength as a function of drug concentration. We present a theory that explains these observations in terms of the interplay between rigidity of the submembranous actin shell and tension that is induced by boundary conditions set by adhesion points. The theory allows estimation of the rigidity and thickness of this supporting shell. The same theoretical considerations explain the shape of nonadherent edges in the general case of untreated cells.
authors.affiliation: Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Bar-Ziv
authors.forename: T
authors.initials: T
authors.lastname: Tlusty
authors.forename: E
authors.initials: E
authors.lastname: Moses
authors.forename: S A
authors.initials: SA
authors.lastname: Safran
authors.forename: A
authors.initials: A
authors.lastname: Bershadsky
mesh_terms: D000199:Actins / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D002460:Cell Line; D048429:Cell Size; D003599:Cytoskeleton / Q000648:ultrastructure*; D008857:Microscopy, Interference / Q000379:methods; D008954:Models, Biological
chemical_list: D000199:Actins