title: Antinociceptive activity of niga-ichigoside F1 from Rubus imperialis.
abstract: This work describes the antinociceptive effect of a triterpene glycoside, niga-ichigoside F1 (1), obtained from an EtOAc extract of the aerial parts of Rubus imperialis. When evaluated against an HOAc-induced writhing model, it exhibited an ID(50) value of 3.1 mg/kg (ip). Moreover, in a formalin-induced pain model, both phases of pain were inhibited by compound 1, with ID(50) values of 2.6 (first phase) and 2.7 (second phase) mg/kg, (ip), respectively.
authors.affiliation: Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Curso de Farmácia/CCS, Universidade do Vale do Itajaí (UNIVALI), 88. 302-202, Itajaí, SC, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Niero
authors.forename: V
authors.initials: V
authors.lastname: Cechinel Filho
authors.forename: M M
authors.initials: MM
authors.lastname: Souza
authors.forename: J L
authors.initials: JL
authors.lastname: Montanari
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
authors.forename: F
authors.initials: F
authors.lastname: Delle Monache
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001938:Brazil; D005557:Formaldehyde; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D012503:Saponins; D005557:Formaldehyde; C090725:niga-ichigoside F1; D019342:Acetic Acid