title: Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats.
abstract: The effect of cromolyn sodium local pre-treatment on capsaicin-induced rhinitis in rats was studied by analyzing tissue changes due to edema, inflammatory cell infiltration and IgA upregulation. Nasal mucosa samples were stained with hematoxylin-eosin and examined immunohistochemically with monoclonal IgA antibodies. Changes were analyzed at 6, 12 and 72 h after capsaicin treatment and were scored semiquantitatively. Results showed that local cromolyn pre-treatment modified all parameters observed in the nasal mucosa following capsaicin-induced rhinitis in the rats.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital "Sestre milosrdnice", Vinogradska 29, HR-10000 Zagreb, Croatia.
authors.forename: T
authors.initials: T
authors.lastname: Baudoin
authors.forename: L
authors.initials: L
authors.lastname: Kalogjera
authors.forename: Z
authors.initials: Z
authors.lastname: Ferencić
authors.forename: H
authors.initials: H
authors.lastname: Cupić
authors.forename: B
authors.initials: B
authors.lastname: Pegan
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D002211:Capsaicin / Q000633:toxicity*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D011292:Premedication; D051381:Rats; D017208:Rats, Wistar; D012220:Rhinitis / Q000139:chemically induced* / Q000473:pathology; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D018927:Anti-Asthmatic Agents; D007070:Immunoglobulin A; D004205:Cromolyn Sodium; D002211:Capsaicin