title: A randomized trial of cefepime and ceftazidime for the treatment of community-acquired pneumonia.
abstract: We compared the effectiveness and safety of ceftazidime and cefepime in hospitalized patients with community-acquired pneumonia. The 148 enrolled patients received 2 g ceftazidime three times daily or 2 g cefepime twice daily. The clinical success rate was the same for both drugs. Even the microbiological effectiveness was similar. Both drug regimens were well tolerated. We conclude that 2 g ceftazidime three times daily were as effective as 2 g cefepime twice daily for the treatment of community-acquired pneumonia in hospitalized patients. The cost of ceftazidime treatment was, however, higher than the cost of cefepime treatment.
authors.affiliation: Division of Pneumology - S. Michele M. Laureto Hospital, Putignano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bonfitto
authors.forename: V
authors.initials: V
authors.lastname: Lamorgese
authors.forename: T
authors.initials: T
authors.lastname: De Vietro
authors.forename: M
authors.initials: M
authors.lastname: Malerba
authors.forename: L
authors.initials: L
authors.lastname: Rizzello
authors.forename: S
authors.initials: S
authors.lastname: Scoditti
authors.forename: R
authors.initials: R
authors.lastname: Zuin
mesh_terms: D000368:Aged; D000077723:Cefepime; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D016527:Drug Costs; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D002511:Cephalosporins; D000077723:Cefepime; D002442:Ceftazidime