title: Metastasis-related genes in prostate cancer.
abstract: The identification of genes specifically related to the development of metastatic disease in prostate cancer is complicated by tumor cell heterogeneity and the presence of expressed sequences that are not related to metastasis. A system was designed to minimize these complications using differential display-polymerase chain reaction (DD-PCR) together with genetically paired cell lines derived from primary mouse prostate cancer and their associated metastases generated in vivo by the metastatic mouse prostate cancer reconstitution model. Using this system, a number of metastasis-related sequences were identified, including a cDNA that encodes caveolin-1.
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Bangma
authors.forename: Y
authors.initials: Y
authors.lastname: Nasu
authors.forename: C
authors.initials: C
authors.lastname: Ren
authors.forename: T C
authors.initials: TC
authors.lastname: Thompson
mesh_terms: D000818:Animals; D051242:Caveolin 1; D022461:Caveolins; D016158:Genes, p53; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: C495540:CAV1 protein, human; C495541:Cav1 protein, mouse; D051242:Caveolin 1; D022461:Caveolins; D008565:Membrane Proteins