Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury.
We aimed to investigate the cardio-protective role of taurine with low calcium level against reperfusion damage by adding taurine to extracellular fluid. Guinea-pig hearts were mounted on Langendorf perfusion apparatus and different compositions of perfusion solutions were prepared for each experimental group. After 20 min of normothermic ischemia the hearts were reperfused. Pre-ischemic, post-ischemic and post-reperfusion percentage changes of heart rate and contractile force were compared. Post-reperfusion tissue weight, malondialdehyde (MDA) and prostaglandin E-like activity (PGE-like activity) were assessed. Taurine-added low-calcium perfusion solution significantly decreased the postischemic myocardial injury.
Oz
E
E
Department of Physiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Erbaş
D
D
Gelir
E
E
Aricioğlu
A
A
D000818:Animals; D002118:Calcium / Q000627:therapeutic use*; D004338:Drug Combinations; D004347:Drug Interactions; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009200:Myocardial Contraction / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011458:Prostaglandins E / Q000032:analysis; D015427:Reperfusion Injury / Q000188:drug therapy*; D013654:Taurine / Q000627:therapeutic use*
D004338:Drug Combinations; D011458:Prostaglandins E; D013654:Taurine; D008315:Malondialdehyde; D002118:Calcium