title: Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain.
abstract: Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions.
authors.affiliation: Division of Obstetrics and Gynecology, Faculty of Health Sciences, Linköping University, Sweden. olof.rugarn@lio.se
authors.forename: O
authors.initials: O
authors.lastname: Rugarn
authors.forename: A
authors.initials: A
authors.lastname: Theodorsson
authors.forename: M
authors.initials: M
authors.lastname: Hammar
authors.forename: E
authors.initials: E
authors.lastname: Theodorsson
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D019004:Galanin / Q000378:metabolism*; D009640:Norethindrone / Q000494:pharmacology*; D010052:Ovariectomy; D010919:Placebos; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D051381:Rats
chemical_list: D010919:Placebos; D011374:Progesterone; D004958:Estradiol; D019004:Galanin; D009640:Norethindrone