Protection of the myocardium with sodium-hydrogen exchange inhibitors: A cardiac surgical perspective.
Strategies for myocardial protection in cardiac surgery are directed at the prevention of procedure-induced ischemia/reperfusion injury as well as metabolic resuscitation in acute ischemic syndromes. Postreperfusion myocardial dysfunction remains a significant clinical problem, most importantly in certain high-risk patient groups. The large body of experimental evidence demonstrating a significant role for sodium-hydrogen exchange activation in myocardial ischemia/reperfusion injury suggests that the ability to pharmacologically inhibit the exchanger presents a promising new approach to current myocardial preservation techniques.
Myers
M L
ML
Division of Cardiovascular Surgery, London Health Sciences Centre-Victoria Campus, London, Ontario, Canada. ML.Myers@LHSC.ON.CA
D000818:Animals; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D017923:Sodium-Hydrogen Exchangers / Q000037:antagonists & inhibitors* / Q000502:physiology*; D019616:Thoracic Surgical Procedures / Q000009:adverse effects*
D017923:Sodium-Hydrogen Exchangers