Facilitation of memory performance by a novel muscarinic agonist in young and old rats.
AF150(S), a partial M1 muscarinic receptor agonist, was tested for its ability to improve performance in rats in a delayed matching-to-position task. Young and old rats received intraperitoneal injections of 0, 1, and 4 mg/kg of AF150(S). AF150(S) significantly enhanced matching accuracy for both young and old rats. Fits of exponential functions to discriminability measures showed that the enhancement was manifest as a reduction in the rate of forgetting. These results indicate that AF150(S) may be a useful therapeutic agent for improving cognitive function.
Ruske
A C
AC
University of Otago, Department of Psychology, Dunedin, New Zealand.
White
K G
KG
D000375:Aging / Q000523:psychology*; D000465:Algorithms; D000818:Animals; D003071:Cognition / Q000187:drug effects; D005260:Female; D008568:Memory / Q000187:drug effects*; D018721:Muscarinic Agonists / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology*
C111926:1-methylpiperidine-4-spiro-(2'-methylthiazoline); D018721:Muscarinic Agonists; D010880:Piperidines; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic; D013844:Thiazoles