Casein kinase II inhibitors isolated from two Brazilian plants Hymenaea parvifolia and Wulffia baccata.
Two dihydroflavonol rhamnosides (1 and 2) isolated from the bark of Hymenaea parvifolia and two pentacyclic triterpenoids (3 and 6) obtained from the leaves of Wulffia baccata have been found to exhibit inhibitory effects of casein kinase II (CK-II) dose-dependently, suggesting that at higher doses more than 10 microM, these four compounds may act as potent CK-II suppressors of the CK-II-mediated activation of 60S acidic ribosomal P proteins in vitro.
Ishibashi
M
M
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Oda
H
H
Mitamura
M
M
Okuyama
E
E
Komiyama
K
K
Kawaguchi
K
K
Watanabe
T
T
de Mello Alves
S
S
Maekawa
T
T
Ohtsuki
K
K
D001938:Brazil; D047390:Casein Kinase II; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols; D010766:Phosphorylation / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D012269:Ribosomal Proteins / Q000378:metabolism; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D005419:Flavonoids; D044948:Flavonols; D012269:Ribosomal Proteins; D014315:Triterpenes; C099069:astilbin; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases