title: Human dirofilariasis in the European Union.
abstract: The dog parasites Dirofilaria immitis and D. (Nochtiella) repens, well known as zoonotic agents, are widely distributed in southern Europe. Although both species are canine parasites, infection with immature worms has been found in humans, who develop nodules, mainly in subcutaneous tissue or in lung parenchyma arising from branches of the pulmonary artery. In humans, the parasites do not usually reach the adult stage and microfilaremia is absent, as has been shown by diagnosis using invasive methods for removing the nodules. In this article, Antonio Muro, Claudio Genchi, Miguel Cordero and Fernando Simón review the current situation concerning the clinical and epidemiological aspects, immune response and diagnosis of human dirofilariases.
authors.affiliation: Laboratorio de Parasitolog a, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Muro
authors.forename: C
authors.initials: C
authors.lastname: Genchi
authors.forename: M
authors.initials: M
authors.lastname: Cordero
authors.forename: F
authors.initials: F
authors.lastname: Simón
mesh_terms: D000328:Adult; D000367:Age Factors; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis / Q000097:blood; D000947:Antigens, Helminth / Q000737:chemistry / Q000276:immunology; D004183:Dirofilaria immitis / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D004184:Dirofilariasis / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D004285:Dogs; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019105:Random Amplified Polymorphic DNA Technique; D014195:Travel; D015047:Zoonoses
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth