[CD44 gene expression in cancerous thyroid cells].
The peculiarities of alternative CD44 mRNA splicing in thyroid cancer tissue of children from radiocontaminated areas was investigated. CD44 gene expression in thyroid cancer tissues of children exposed to radiation resembled that in spontaneously emerged cancers. It was concluded that CD44 gene expression is not the primary target of radioactive irradiation. Probably, the CD44 mRNA splicing deregulation is the consequence of cancer.
Pisarchik
A V
AV
Kartel'
N A
NA
Ermak
G Z
GZ
Figge
J
J
D017398:Alternative Splicing / Q000235:genetics / Q000528:radiation effects; D001483:Base Sequence; D002291:Carcinoma, Papillary / Q000235:genetics*; D002648:Child; D017931:DNA Primers; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics* / Q000528:radiation effects; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics* / Q000528:radiation effects; D008969:Molecular Sequence Data; D009857:Oncogenes / Q000235:genetics* / Q000528:radiation effects; D016133:Polymerase Chain Reaction / Q000379:methods; D011210:Power Plants; D012333:RNA, Messenger / Q000235:genetics / Q000528:radiation effects; D018788:Radioactive Hazard Release; D002094:Republic of Belarus; D013961:Thyroid Gland / Q000528:radiation effects; D013964:Thyroid Neoplasms / Q000235:genetics*; D014455:Ukraine
D017931:DNA Primers; D018960:Hyaluronan Receptors; D012333:RNA, Messenger