Expression pattern of macrophage migration inhibitory factor during embryogenesis.
Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis.
Kobayashi
S
S
Functional Genomics Unit, Gene Targeting Facility, Bethesda, MD 20892, USA.
Satomura
K
K
Levsky
J M
JM
Sreenath
T
T
Wistow
G J
GJ
Semba
I
I
Shum
L
L
Slavkin
H C
HC
Kulkarni
A B
AB
D000818:Animals; D000831:Animals, Newborn; D018507:Gene Expression Regulation, Developmental; D008099:Liver / Q000196:embryology / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D009130:Muscle, Smooth / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D009420:Nervous System / Q000196:embryology / Q000378:metabolism; D013737:Testis / Q000196:embryology / Q000378:metabolism
D008263:Macrophage Migration-Inhibitory Factors