title: Protein and RNA of human telomerase as targets for modified oligonucleotides.
abstract: Chimeric oligodeoxynucleotides containing phosphorothioate and N3'-->P5' phosphoramidate linkages were synthesized. These oligomers show a high inhibitory activity against human telomerase.
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: von Janta-Lipinski
authors.forename: K
authors.initials: K
authors.lastname: Gaertner
authors.forename: C
authors.initials: C
authors.lastname: Lehmann
authors.forename: H
authors.initials: H
authors.lastname: Scheer
authors.forename: J
authors.initials: J
authors.lastname: Schildt
authors.forename: E
authors.initials: E
authors.lastname: Matthes
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D009841:Oligonucleotides / Q000494:pharmacology*; D012313:RNA / Q000187:drug effects*; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D012313:RNA; D019098:Telomerase