Anticoagulation with r-hirudin in a patient with acute renal failure and heparin-induced thrombocytopenia.
After a Caesarean section subcutaneous bleeding with a secondary infection occurred accompanied by acute renal failure. Additionally the diagnosis of a heparin-induced thrombocytopenia type II could be made. Therefore, haemodialysis treatments were performed with r-hirudin as an alternative anticoagulation. Even in dialysis dependent acute renal failure a safe anticoagulation with r-hirudin is possible if aPTT and plasma r-hirudin are closely monitored.
Steuer
S
S
Department of Nephrology and Rheumatology, Heinrich-Heine-University Düsseldorf, Germany.
Boogen
C
C
Plum
J
J
Deppe
C
C
Reinauer
H
H
Grabensee
B
B
D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology*; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins / Q000494:pharmacology*; D006801:Humans; D011994:Recombinant Proteins / Q000494:pharmacology; D006435:Renal Dialysis; D013921:Thrombocytopenia / Q000139:chemically induced*
D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin