title: Making drugs out of oligonucleotides: a brief review and perspective.
abstract: I provide a brief review and perspective thoughts concerning the antisense oligonucleotide, drug discovery paradigm.
authors.affiliation: Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Cook
mesh_terms: D015195:Drug Design; D009841:Oligonucleotides / Q000138:chemical synthesis*
chemical_list: D009841:Oligonucleotides