[Experimental xenogenic lung transplantation].
Lung transplantation has become a valuable therapeutical option for patients with end stage vascular and parenchymal pulmonary disease. The main limitation is the donor organ shortage, which is for lung transplantation even more pronounced than for other solid organs. Therefore, the search for alternative sources in the field of xenotransplantation as potential bridging to human allograft transplantation has emerged over the last few years. Pulmonary xenotransplantation at this stage is still an experimental procedure. Different concordant and discordant models have been investigated for specific organ functions, but in subhuman models no long-term function could be achieved to date. The purpose of this article is to present recent results in pulmonary xenotransplantation models.
Fraund
S
S
Klinik für Herz- und Gefässchirurgie, Medizinische Hochschule Hannover.
Steinhoff
G
G
Haverich
A
A
D000818:Animals; D006801:Humans; D016040:Lung Transplantation; D008954:Models, Biological; D014183:Transplantation, Heterologous; D016896:Treatment Outcome