Interleukin-10: a cytokine used by tumors to escape immunosurveillance.
The mechanisms whereby malignant cells can elude the recognition of the immune system, by what is termed 'immunological escape', have attracted major attention of tumor immunologists during the past decade. In this review, the role of the immunosuppressive cytokine interleukin-10 (IL-10) will be discussed as a strategy used by tumors to avoid recognition by cytotoxic T lymphocytes (CTL).
Salazar-Onfray
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Department of Oncology, Karolinska Hospital, Stockholm, Sweden. fsalazar@machi.med.uchile.cl
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005805:Genes, MHC Class I / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D016753:Interleukin-10 / Q000276:immunology* / Q000502:physiology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D013491:Suppressor Factors, Immunologic / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic; D019139:Tumor Escape
D013491:Suppressor Factors, Immunologic; D016753:Interleukin-10