Synthesis and biological evaluation of carbocyclic analogues of lipid X: new nonpolar antagonists of LPS induced TNF production.
We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for endotoxic shock.
Augy-Dorey
S
S
Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France.
Billington
D C
DC
Camara
J A
JA
Gero
S D
SD
Sagnard
I
I
Quiclet-Sire
B
B
Ghezzi
D
D
D000146:Acids, Carbocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004347:Drug Interactions; D006017:Glycolipids / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D012772:Shock, Septic / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000146:Acids, Carbocyclic; D006017:Glycolipids; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C044283:lipid X