The mobile order solubility equation applied to polyfunctional molecules: The non-hydroxysteroids in aqueous and non aqueous solvents.
The solubility equation for real solutions derived from the thermodynamics of mobile order in liquids is used to predict the solubility of non-hydroxysteroids in water and in common polar and nonpolar organic solvents. Strictly obtained on a thermodynamic basis, the model allows not only correct predictions of the solubilities from the knowledge of a limited number of characteristics of solutes and solvents, but also enables a better understanding of the solution process and of the factors that determine solubility. Some practical rules are derived which might help to orient the choice of a solvent for liquid pharmaceutical forms.
Ruelle
P
Institut d'Analyse Pharmaceutique, Section de Pharmacie, Université de Lausanne, BEP, CH-1015, Lausanne, Switzerland
Farina-Cuendet
A
Kesselring
UW