Metronidazole ototoxicity--report of two cases.
Two cases of bilateral moderate to severe sensorineural hearing loss due to oral administration of metronidazole are reported. There has been only one case report of deafness following metronidazole therapy in the world literature. The hearing loss recovered gradually in a period of four to six weeks following withdrawal of drug and oral steroid therapy. The possible mechanism of ototoxicity is discussed. Awareness by the treating physician of ototoxicity due to any drug is stressed.
Iqbal
S M
SM
Department of Otorhinolaryngology, JLN Hospital, Bhilai, India.
Murthy
J G
JG
Banerjee
P K
PK
Vishwanathan
K A
KA
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001301:Audiometry, Pure-Tone; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects*; D011239:Prednisolone / Q000627:therapeutic use; D014012:Tinnitus / Q000139:chemically induced* / Q000188:drug therapy
D000890:Anti-Infective Agents; D005938:Glucocorticoids; D008795:Metronidazole; D011239:Prednisolone