An experimental study of electro-acupuncture on auditory impairment caused by kanamycin in guinea pigs.
Frequency following response (FFR) and auditory brain stem evoked potential response (ABR) were used to determine the auditory acuity in evaluating the effect of electro-acupuncture treatment of kanamycin-induced auditory impairment in guinea pigs. The succinate dehydrogenase (SDH) activity and morphological changes of the inner ear receptors were examined under the light and scanning electron microscope in cochlear spread preparations. The results showed that 1) electro-acupuncture was effective but no significant differences were found among the stimulating wave forms; 2) Tinggong (SI 19), Yifeng (SJ 17), Shenshu (UB 23), Sanyinjiao (Sp 6), Zhubin (K 9) and Waiguan (SJ 5) are all effective acupoints, especially the combination of Tinggong (SI 19), Sanyinjiao (Sp 6) and Zhubin (K 9) acupoints; 3) improvement in the cochlear function and excitability of the cortical and lower auditory center and increase of the mitochondrial SDH activity and energy supply in hair cells might contribute to the mechanism of the treatment.
Liu
Y
Y
Acupuncture, Moxibustion and Massage Department of Zhejiang TCM College, Hangzhou.
Fang
J
J
Sun
D
D
Jin
X
X
Wu
Y
Y
Wang
Y
Y
Song
R
R
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003051:Cochlea / Q000473:pathology; D003638:Deafness / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology*; D015671:Electroacupuncture; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs; D007612:Kanamycin / Q000009:adverse effects*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007612:Kanamycin; D013385:Succinate Dehydrogenase