What can the investigation of phosphoinositide signaling system in platelets of schizophrenic patients tell us?
Disturbances in the regulation of the phosphoinositide signaling system have been proposed as a possible biological marker of schizophrenia. This review considers the laboratory investigations of phosphoinositide metabolism in platelets of schizophrenic patients. We suggest that alterations in the inositol phosphate level and a disturbance of calcium homeostasis may be common denominators for the multiple factors implicated in the pathogenesis of schizophrenia. In addition, these abnormalities may account for the diverse clinical and biochemical manifestations of schizophrenia.
Strunecká
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Charles University, Faculty of Sciences, Department of Physiology and Developmental Biology, Prague, Czech Republic. astrun@cesnet.cz
Rípová
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D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000097:blood; D006801:Humans; D010716:Phosphatidylinositols / Q000097:blood*; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012559:Schizophrenia / Q000097:blood*; D015398:Signal Transduction
D010716:Phosphatidylinositols; D017981:Receptors, Neurotransmitter; D002118:Calcium