title: 3He ion-beam analysis of water uptake and drug delivery.
abstract: 3He ion-beam analysis utilises a micronuclear reaction analysis (of deuterium and carbon) and microparticle induced X-ray emission (in this case silicon and chlorine), to determine an elemental map of the surface of a sample. This study used D(2)O to model the behaviour of water in poly(tetrahydrofurfuryl methacrylate-polyethyl methacrylate) and chlorhexidine diacetate doped silicone elastomers. The poly(tetrahydrofurfuryl methacrylate-polyethyl methacrylate) systems demonstrated an initial Fickian absorption process (diffusion coefficient 1.1 x 10(-11) m(2)s(-1)) which indicated the 2-stage nature of the polymer's absorption kinetics. The doped silicone samples demonstrated an osmotic mechanism for the controlled release of drugs, with correlation between the D(2)O and the chlorhexidine diacetate inclusions increasing during the experiment. The technique proved valuable in the analysis of delivery polymers and will undoubtedly have further applications in the development of drug delivery systems.
authors.affiliation: Department of Biomaterials in Relation to Dentistry, IRC in Biomedical Materials, St. Barts. and Royal London School of Medicine and Dentistry, Queen Mary Westfield College, University of London, London, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Riggs
authors.forename: A S
authors.initials: AS
authors.lastname: Clough
authors.forename: P M
authors.initials: PM
authors.lastname: Jenneson
authors.forename: D W
authors.initials: DW
authors.lastname: Drew
authors.forename: M
authors.initials: M
authors.lastname: Braden
authors.forename: M P
authors.initials: MP
authors.lastname: Patel
mesh_terms: D002710:Chlorhexidine / Q000008:administration & dosage / Q000737:chemistry; D017666:Deuterium Oxide; D004058:Diffusion; D016503:Drug Delivery Systems; D011108:Polymers; D012828:Silicones; D014867:Water
chemical_list: D011108:Polymers; D012828:Silicones; D014867:Water; D017666:Deuterium Oxide; D002710:Chlorhexidine