Glioblastoma multiforme in a mature ovarian teratoma with recurring brain tumours.
OBJECTIVE
We report a case study to highlight the occurrence of glioblastoma multiforme in an ovarian teratoma.


RESULTS
A 10-year-old girl presented with a left frontal lobe primitive neuroectodermal tumour which was successfully treated. After 6 uneventful years, she developed glioblastoma multiforme located posterior to the site of the initial tumour. Six years later, she presented with a mature cystic teratoma containing glioblastoma multiforme.


CONCLUSIONS
Glioblastoma in an ovarian teratoma is an exceptional event, which might have an initial clinical presentation as a metastatic brain tumour. Alternatively, recurring glial tumours may occur in a genetically predisposed person; the role of radiation and chemotherapy in this context remains to be elucidated.
Yadav
A
A
Department of Pathology, Institut Gustave Roussy, Villejuif, France.
Lellouch-Tubiana
A
A
Fournet
J C
JC
Quazza
J E
JE
Kalifa
C
C
Sainte-Rose
C
C
Jaubert
F
F
D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013724:Teratoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
D014408:Biomarkers, Tumor