Anaphylactic response to parasite antigens: IgE and IgG1 independently induce death in Trichinella-infected mice.
The response of animals infected with different Trichinella species (T. spiralis, T. britovi, T. pseudospiralis) to antigens of different Trichinella species was evaluated in outbred mice (CD1) and inbred mice (BALB/c, C3H, SJL, C57BL/6). In mice deficient for IgE or IgG1, T. spiralis only was used. In homologous conditions (i. e., same Trichinella species for antigens and infectious agent) mortality was very high (up to 100% in SJL and C57BL/6). The anaphylactic response in heterologous conditions was much lower and death was observed only in C57BL/6 and SJL mice. Experiments with deficient mice have shown that both specific IgE and IgG1 independently induce a fatal anaphylactic response.
Bruschi
F
F
Institute of General Pathology, University of Perugia, Policlinico Monteluce, Perugia, Italy. f.bruschi@sanitpubb.med.unipi.it
Pozio
E
E
Watanabe
N
N
Gomez-Morales
M A
MA
Ito
M
M
Huang
Y
Y
Binaghi
R
R
D000707:Anaphylaxis / Q000276:immunology* / Q000401:mortality; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology* / Q000633:toxicity; D005260:Female; D015801:Helminth Proteins / Q000032:analysis; D007121:Immunocompetence; D007073:Immunoglobulin E / Q000172:deficiency / Q000502:physiology*; D007074:Immunoglobulin G / Q000502:physiology*; D051379:Mice; D020297:Mice, Congenic; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013997:Time Factors; D014234:Trichinella / Q000737:chemistry / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology* / Q000401:mortality
D000947:Antigens, Helminth; D015801:Helminth Proteins; D007074:Immunoglobulin G; D007073:Immunoglobulin E