title: The adenovirus that causes hemorrhagic disease of black-tailed deer is closely related to bovine adenovirus-3.
abstract: DNA sequence data was obtained from an adenovirus previously shown to be the cause of a distinctive, fatal hemorrhagic disease of black-tailed deer in California. A 256 base fragment of the viral hexon gene was amplified by PCR from purified adenovirus preparations. The amplicon then was cloned and sequenced. Phylogenetic relationships with other mammalian adenoviruses were also determined. Although sequence analysis of this portion of the hexon gene indicates that the black-tailed deer adenovirus is closely related to bovine adenovirus-3, the biologic properties of the two viruses are clearly distinct.
authors.affiliation: Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Lapointe
authors.forename: J F
authors.initials: JF
authors.lastname: Hedges
authors.forename: L W
authors.initials: LW
authors.lastname: Woods
authors.forename: G H
authors.initials: GH
authors.lastname: Reubel
authors.forename: N J
authors.initials: NJ
authors.lastname: MacLachlan
mesh_terms: D000257:Adenoviridae Infections / Q000150:complications* / Q000821:virology; D000595:Amino Acid Sequence; D000818:Animals; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D002417:Cattle; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D003670:Deer / Q000821:virology*; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D017921:Mastadenovirus / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C018315:hexon capsid protein, Adenovirus