Homologous regulation of 5-HT1A receptor mRNA in adult rat hippocampal dentate gyrus.
Short-term adrenalectomy induces a loss of mature granular neuronal phenotypes in the hippocampal dentate gyrus; injection of 5-HT1A receptor agonist reverses this effect. Adrenalectomy also induces an increase of expression of 5-HT1A receptor mRNA in the dentate gyrus. This study tested the effect of 5-HT1A agonist on this adrenalectomy-induced increase of 5-HT1A mRNA. Five, 9 and 18 days after adrenalectomy, 5-HT1A receptor mRNA is increased in the granular layer of the dentate gyrus. The increase is nearly 100% at day 18 after adrenalectomy. 5-HT1A agonist treatment decreased 5-HT1A mRNA both at 9 (20%) and 18 days (34%) after adrenalectomy. Our results indicated that a 5-HT1A agonist can partly reverse the adrenalectomy-induced increase of 5-HT1A mRNA and loss of mature granular neuronal phenotypes in hippocampal dentate gyrus.
Huang
J
J
Department of Biology, New York University, NY 10003, USA.
Azmitia
E C
EC
D000315:Adrenalectomy; D000818:Animals; D018891:Dentate Gyrus / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D011743:Pyrimidines; D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; C043077:ipsapirone