[Suicidal self poisoning with disulfiram in a 15-year old boy with resulting encephalopathy].
Acute intentional overdoses of disulfiram (app. 30 g) is reported in 15-years-old boy. The neurological disturbances as nystagmus, coma, seizures and than impairment of memory and perception were dominated in the clinical picture. During MRI examination the areas of different signal from corpus callosum were detected which can be referred to focus of demyelinisation. The patient recovered and was discharged from the hospital after 30 days. Neuropsychological examinations have suggested dysfunction of CNS. The control MRI examination 90 days later, did not reveal any pathological changes in the brain.
Goszcz
H
H
Kliniki Toksykologii KMP i ChS Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Groszek
B
B
Urbanik
A
A
Szczepańska
L
L
Wiernikowski
A
A
D000293:Adolescent; D003337:Corpus Callosum / Q000187:drug effects / Q000473:pathology; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004221:Disulfiram / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D009483:Neuropsychological Tests; D009759:Nystagmus, Pathologic / Q000139:chemically induced; D012640:Seizures / Q000139:chemically induced; D013406:Suicide, Attempted
D004221:Disulfiram