title: Ketanserin, an antagonist of 5-HT2A receptor of serotonin, inhibits testosterone secretion by rat Leydig cells in vitro.
abstract: The effect of ketanserin, an antagonist of 5-HT2A receptor of serotonin, added to the culture medium, on basal and LH-stimulated testosterone secretion was studied in primary cultures of adolescent rat Leydig cells. Ketanserin decreased the basal secretion of testosterone but showed an insignificant influence on the LH-stimulated process. It can be concluded that ketanserin may affect the testosterone-secreting cells by an indirect action at the vascular level as well as directly at the level of Leydig cells, at least in adolescent rats, leading to down-regulation of the basal testosterone secretion.
authors.forename: I
authors.initials: I
authors.lastname: Pieścikowska
authors.forename: P
authors.initials: P
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Lukaszyk
authors.forename: L
authors.initials: L
authors.lastname: Górska-Rafińska
authors.forename: M
authors.initials: M
authors.lastname: Balcerek
authors.forename: H
authors.initials: H
authors.lastname: Ludwiczak
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007650:Ketanserin / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013739:Testosterone / Q000378:metabolism
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013739:Testosterone; D007650:Ketanserin