Transcription: Common cofactors and cooperative recruitment.
Mammalian counterparts of the yeast SRB/MED transcriptional 'mediator' complex have recently been identified. These complexes define a common cofactor requirement for diverse transcriptional activators and underscore the conserved nature of the transcriptional machinery among eukaryotic organisms.
Wu
W H
WH
Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.
Hampsey
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D000818:Animals; D056850:Cyclin-Dependent Kinase 8; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D029721:Drosophila Proteins; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D056892:Mediator Complex; D012319:RNA Polymerase II / Q000502:physiology; D016601:RNA-Binding Proteins; D012097:Repressor Proteins / Q000502:physiology; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000502:physiology; D035362:Transcription Factor TFIID; D014157:Transcription Factors / Q000502:physiology*; D019473:Transcription Factors, TFII / Q000502:physiology; D015533:Transcriptional Activation
D029721:Drosophila Proteins; D005656:Fungal Proteins; C110184:MED7 protein, S cerevisiae; D056892:Mediator Complex; C095061:RGR1 protein, S cerevisiae; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D017412:Ribonucleoprotein, U1 Small Nuclear; C118425:SAGA protein, Emericella nidulans; C082148:SRB4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D035362:Transcription Factor TFIID; D014157:Transcription Factors; D019473:Transcription Factors, TFII; C089969:snf protein, Drosophila; D056850:Cyclin-Dependent Kinase 8; D018844:Cyclin-Dependent Kinases; C498309:SSN3 protein, S cerevisiae; D012319:RNA Polymerase II