Microbes and sequestered substances as mechanisms for disease: Bartonella and L-forms as common global etiological agents.
The pathogenicity of microbes may be determined by substances sequestered from blood and bound to their constituent lipid. The brain may not perceive substances sequestered by microbes, to interfere with control to maintain normal levels. Pathological conditions can be induced as organisms exposed to antimicrobial substances/conditions and/or deprived of nutrients essential to cell wall synthesis, disintegrate to free lipid-bound compounds and produce L-forms that can deplete nutrients as they revert to bacteria. Microbes may act as active carriers for the continuing interaction of sequestered substances. Changes in the molecular structure of substances effected during sequesteration could cause them to be seen as substances 'synthesized' by an organism. In media that contain substances to inhibit 'contaminants', L-forms can be seen as mycoplasma. Elementary bodies of L-forms with a specific substance or tissue affinity may be seen as 'receptors'. Bartonella are global agents for disease--pleomorphic organisms (description suits Proteus)--and they can be seen as 'contaminants'.
Sood
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faith@giaspn01.vsnl.net.in
Khatpe
D S
DS
Chaudhari
M S
MS
Phatak
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VD
D001473:Bartonella / Q000472:pathogenicity* / Q000502:physiology; D001474:Bartonella Infections / Q000503:physiopathology*; D001921:Brain / Q000382:microbiology; D006801:Humans; D008954:Models, Biological