[Clinical and immunochemical characteristics of remittent multiple sclerosis].
Immunochemical monitoring was used to examine 37 patients with remittent multiple sclerosis (MS) for 3 years. There were changes in the blood concentrations of the supernatants IL-1 beta, IL-2, IL-6, alpha-TNF, in the serum levels of the adhesion molecule sVCAM, the neurospecific proteins GFAP and alpha 2GP. Only does active MS show a simultaneous increase in the serum concentrations of SVCAM and GFAP and alpha 2GP, which may be used as a test for the objectification of MS aggravation, the efficiency of therapy. The revealed higher secretion of antiinflammatory of cytokines at all disease stages, no recovery of blood-brain barrier responsiveness and at remission provide evidence for the likelihood of a permanent immunopathological process in MS with prevailing inflammatory and destructive changes during a clinical exacerbation and of the induction of active astrogliosis at its remission.
Gusev
E I
EI
Beliaeva
I A
IA
Chekhonin
V P
VP
Demina
T L
TL
Boĭko
A N
AN
Buglak
A V
AV
Gurina
O I
OI
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001812:Blood-Brain Barrier; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000097:blood / Q000276:immunology*; D006801:Humans; D007378:Interleukins / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology; D012008:Recurrence; D016211:Transforming Growth Factor alpha / Q000097:blood / Q000276:immunology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood / Q000276:immunology*
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D007378:Interleukins; D016211:Transforming Growth Factor alpha; D019010:Vascular Cell Adhesion Molecule-1