title: [Three cases of semi-invasive pulmonary aspergillosis occurring in healthy or diabetic individuals].
abstract: We encountered three cases of suspected semi-invasive pulmonary aspergillosis, occurring in healthy or diabetic patients. Radiographic findings disclosed cavity formation in 2 of the patients, but only nodular lesions in 1. The beta-D glucan level was elevated in 1 patient, but was within the normal range in the other 2. Morphological findings indicated that all 3 patients had pulmonary aspergillosis. Following the oral administration of FLCZ to 1 patient and ITCZ to the other 2 for about 2 months, the radiographic lesions resolved and hematologic inflammatory reactions cleared up. Gefter et al and Sider et al have defined 2 types of aspergillosis that occur in mildly immuno-compromised or healthy individuals: the semi-invasive type, which destroys pulmonary tissue without vascular invasion and leads to cavity formation; and the locally invasive type, which is characterized by nodular or massive radiographic lesions without cavity formation. Semi-invasive aspergillosis was diagnosed in all 3 of the cases we reported.
authors.affiliation: Fifth Department of Internal Medicine, Tokyo Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Kashiwabara
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Shimizutani
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: G
authors.initials: G
authors.lastname: Sarashina
authors.forename: F
authors.initials: F
authors.lastname: Tuchida
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: H
authors.initials: H
authors.lastname: Yagyu
authors.forename: K
authors.initials: K
authors.lastname: Matsuoka
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000175:diagnosis; D048909:Diabetes Complications; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis; D008297:Male; D008875:Middle Aged