Does formate reduce alpha-ketoglutarate and ammonia to glutamate?
The reported reduction of alpha-ketoglutarate and ammonia by formate is much slower than described (Morowitz et al., 1995). The formate reduction if any is small under these conditions. Glutamate is produced from a reduction by a second molecule of alpha-ketoglutarate involving an oxidative decarboxylation.
Maughan
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Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093-0506, USA.
Miller
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D000641:Ammonia / Q000378:metabolism*; D005561:Formates / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008956:Models, Chemical; D010084:Oxidation-Reduction; D012996:Solutions
D005561:Formates; D007656:Ketoglutaric Acids; D012996:Solutions; C030544:formic acid; D018698:Glutamic Acid; D000641:Ammonia