title: A phase II study of a three-drug combination (cisplatin, ifosfamide and vinorelbine) plus granulocyte-colony stimulating factor in advanced non small cell lung cancer.
abstract: Twenty-nine patients with advanced non-small-cell lung cancer (NSCLC) were treated with a combination of cisplatin 20 mg/m2 days 1-3, ifosfamide 1500 mg/m2 days 1-2 (plus mesna as uroprotector) and vinorelbine 25 mg/m2 days 1 and 5; filgrastim was given at the dose of 300 microg subcutaneously from day 8 to day 15. A response rate of 28% was observed. The activity of this combination in an outpatient setting, with acceptable toxicity, has been demonstrated.
authors.affiliation: Dept. of Medical Oncology, Ospedale S. Andrea, La Spezia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tognoni
authors.forename: L
authors.initials: L
authors.lastname: Cadenotti
authors.forename: F
authors.initials: F
authors.lastname: Pensa
authors.forename: F
authors.initials: F
authors.lastname: Vaira
authors.forename: A
authors.initials: A
authors.lastname: Vigani
authors.forename: L
authors.initials: L
authors.lastname: Bancalari
authors.forename: S
authors.initials: S
authors.lastname: Cordani
authors.forename: R
authors.initials: R
authors.lastname: Maggiani
authors.forename: P A
authors.initials: PA
authors.lastname: Canessa
authors.forename: P
authors.initials: P
authors.lastname: Pronzato
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D015080:Mesna / Q000008:administration & dosage; D008875:Middle Aged; D020011:Protective Agents / Q000008:administration & dosage; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives
chemical_list: D020011:Protective Agents; D016179:Granulocyte Colony-Stimulating Factor; D014747:Vinblastine; D015080:Mesna; D002945:Cisplatin; D007069:Ifosfamide