Effect of cromolyn pre-treatment on capsaicin-induced rhinitis in rats.
The effect of cromolyn sodium local pre-treatment on capsaicin-induced rhinitis in rats was studied by analyzing tissue changes due to edema, inflammatory cell infiltration and IgA upregulation. Nasal mucosa samples were stained with hematoxylin-eosin and examined immunohistochemically with monoclonal IgA antibodies. Changes were analyzed at 6, 12 and 72 h after capsaicin treatment and were scored semiquantitatively. Results showed that local cromolyn pre-treatment modified all parameters observed in the nasal mucosa following capsaicin-induced rhinitis in the rats.
Baudoin
T
T
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital "Sestre milosrdnice", Vinogradska 29, HR-10000 Zagreb, Croatia.
Kalogjera
L
L
Ferencić
Z
Z
Cupić
H
H
Pegan
B
B
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D002211:Capsaicin / Q000633:toxicity*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D011292:Premedication; D051381:Rats; D017208:Rats, Wistar; D012220:Rhinitis / Q000139:chemically induced* / Q000473:pathology; D015854:Up-Regulation / Q000187:drug effects
D018927:Anti-Asthmatic Agents; D007070:Immunoglobulin A; D004205:Cromolyn Sodium; D002211:Capsaicin