Gastric neuroendocrine cells and secretory products.
The ECL cell is the most common cell type in the oxyntic mucosa of the stomach. It is producing a number of peptides and amines where histamine and chromogranin A seems to be the most important and abundant products. Recent data indicate a direct correlation between ECL-cell mass and circulating chromogranin A levels. Chromogranin A and its splice products might serve as growth promoting agents in ECL-cell hyperplasia or gastric carcinoids.
Oberg
K
K
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
D000818:Animals; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D004064:Digestive System / Q000196:embryology; D019861:Enterochromaffin-like Cells / Q000378:metabolism; D019858:Enteroendocrine Cells / Q000378:metabolism*; D004848:Epithelium / Q000196:embryology; D006640:Histidine Decarboxylase / Q000378:metabolism; D006801:Humans; D009490:Neurosecretory Systems / Q000166:cytology* / Q000502:physiology; D016708:Synaptophysin / Q000378:metabolism
D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin; D006640:Histidine Decarboxylase