In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites.
The inhibitory effect of flavonoids and phenolic acids, which could be transformed from flavonoids by human intestinal microflora, on the growth of Helicobacter pylori (HP) was investigated. Ponciretin, hesperetin, naringenin and diosmetin were active against HP. Among them, ponciretin was the most potent and its MIC was 10-20 micrograms/ml. However, these active compounds against HP did nearly not inhibit the urease activity of HP.
Bae
E A
EA
Han
M J
MJ
Kim
D H
DH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D006569:Hesperidin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D011706:Pyloric Antrum
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D044950:Flavanones; D005419:Flavonoids; D010636:Phenols; D006569:Hesperidin; C005273:naringenin; C039602:diosmetin