Caries-preventive effects of sodium and amine fluoride dentifrices.
OBJECTIVE
To determine the comparative effects of sodium (NaF) and amine fluoride dentifrices, as well as the effect of different silica abrasives used in NaF dentifrices, on caries formation in rats.


METHODS
Harlan Sprague Dawley mixed sex, weanling, littermate rats were fed a cariogenic diet and inoculated with S. sobrinus strain 6715 to induce caries formation. The dentifrices evaluated contained 0.31% NaF with precipitated silica I as the abrasive system; 0.31% NaF with sodium bicarbonate and hydrated silica; placebo; amine fluoride (0.14%) containing silica (Elmex); 0.31% NaF with precipitated silica II (Sensodyne F); and 0.31% NaF with hydrated silica. Dentifrice slurries were administered 7 days per week for 3 weeks at which time the animals were euthanized and the hemijaws removed, coded and stained with a murexide solution. The recovery of S. sobrinus after the 3-week study clearly showed that all of the six groups were infected with S. sobrinus. The Keyes scoring method was then used to assess the caries formation within the six groups.


RESULTS
Caries scores showed that all five experimental fluoride dentifrices were equally efficacious statistically in reducing caries formation when compared to the placebo with reductions ranging from 26 to 43%.
Warrick
J M
JM
Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis 46202-2876, USA.
Miller
L L
LL
Doan
E J
EJ
Stookey
G K
GK
D000588:Amines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003959:Diamines; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide; D012969:Sodium Fluoride / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018709:Statistics, Nonparametric
D000588:Amines; D002327:Cariostatic Agents; D003802:Dentifrices; D003959:Diamines; D004338:Drug Combinations; D012822:Silicon Dioxide; C495399:Olaflur; D012969:Sodium Fluoride; D005459:Fluorides