Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.
Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity.
Jamison
J
J
Department of Urology, Summa Health System/N.E. Ohio Universities College of Medicine, Rootstown 44272, USA.
Gilloteaux
J
J
Nassiri
M R
MR
Tsai
C C
CC
Summers
J
J
D000998:Antiviral Agents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008274:Magnesium / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011063:Poly A-U / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*
D000998:Antiviral Agents; D011063:Poly A-U; D008274:Magnesium