The antioxidative effect of ganhuangenin against lipid peroxidation.
The antioxidative effect of ganhuangenin (GHG), isolated from Scutellaria baicalensis Georgi, was examined by measuring its ability to suppress the formation of phospatidylcholine hydroperoxide (PCOOH). The results show that a pretreatment with GHG effectively suppressed PCOOH formation, which was initiated by the peroxyl-generating oxidant, AAPH (2,2'-azobis-2-aminopropane hydrochloride). The protective action of GHG against the formation of the PCOOH was observed in liver, lung, and kidney. When compared with other known antioxidants, we found the antioxidative potency of GHG to be greater than that of alpha-tocopherol. Our data strongly indicate that GHG is a powerful antioxidant against lipid peroxidation and is, therefore, responsible for this prophylactic effect.
Lim
B O
BO
Department of Physiology, The University of Texas Health Science Center, San Antonio, Texas, 78284-7756, USA.
Yu
B P
BP
Kim
S C
SC
Park
D K
DK
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology
D000975:Antioxidants; D005419:Flavonoids; D010713:Phosphatidylcholines; D010936:Plant Extracts; C057590:phosphatidylcholine hydroperoxide; D019207:beta Carotene; D014810:Vitamin E; C047101:ganhuangenin; D011794:Quercetin