Secondary supratentorial anaplastic astrocytoma following treatment of medulloblastoma.
The development of secondary tumours is a rare but well known late effect of radiation therapy of lesions in the central nervous system. Most radiation-induced tumours are of mesenchymal origin, but on rare occasions gliomas can occur. We describe a patient in whom a supratentorial anaplastic astrocytoma developed 15 years after surgery and radiotherapy for a childhood posterior fossa medulloblastoma. A concise review of the pertinent literature is given.
Van Calenbergh
F
F
Department of Neurosurgery, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
D'Haen
B
B
Dom
R
R
Menten
J
J
Plets
C
C
D001254:Astrocytoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D001921:Brain / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D002648:Child; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery