title: Impairment of renal sodium excretion in tropical residents--phenomenological analysis.
abstract: There is evidence of impaired renal sodium excretion in salt-sensitive African Blacks. A decreased rate of renal sodium chloride (NaCl) excretion, low plasma renin activity and a tendency to elevated blood pressure are the hallmarks of salt sensitivity. Recent evidence indicates that increased proximal and distal tubular fluid reabsorption in some tropical residents may explain the impaired sodium excretion in these people. In this study of a cohort population, we speculated that subjects selected from that population might be salt-sensitive. We therefore measured the sodium balance in 10 normotensive male subjects over 10 consecutive days, after they had ingested a normal or a high amount of sodium, as NaCl (salt) in their diet. We quantified their renal sodium excretion rate by phenomenological analysis of their sodium balance data. We also measured plasma renin activity for 7 consecutive days in a separate group of 6 male and 4 female subjects in order to assess the state of their renin/angiotensin system. We selected all our subjects from a cohort population of 269 subjects randomly selected from a community known to have a high prevalence of primary hypertension. Our data on two separate groups of subjects from the same cohort population revealed delayed renal sodium excretion with t1/2 of about 5 days, compared to published data for normal individuals with t1/2 of less than 24 h. Also, plasma renin activity levels were low. Hence, our subjects are salt-sensitive. Quantification of their renal impairment is important for various reasons: it heightens one's appreciation of the problem of salt retention in African Blacks who are salt-sensitive and it also underlines the importance of the need for further research into the benefits of dietary salt restriction for reducing cardiovascular mortality in African populations, as has been done in some Western countries.
authors.affiliation: Department of Physiology, University of Ghana Medical School, Accra, Ghana. arthur.@compcentre.uz.ac.zw
authors.forename: S K
authors.initials: SK
authors.lastname: Arthur
authors.forename: P A
authors.initials: PA
authors.lastname: Aryee
authors.forename: J
authors.initials: J
authors.lastname: Amuasi
authors.forename: I F
authors.initials: IF
authors.lastname: Hesse
authors.forename: R K
authors.initials: RK
authors.lastname: Affram
mesh_terms: D000328:Adult; D044383:Black People; D001834:Body Water / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D005869:Ghana; D006801:Humans; D007668:Kidney / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000502:physiology*; D012083:Renin / Q000097:blood; D014329:Tropical Climate
chemical_list: D012083:Renin