Growth factor network disruption in prostate cancer progression.
Prostate cancer progression is often accompanied by alterations in expression of one or more growth factor receptors and/or their ligands. This commentary examines the hypothesis that the disruption of the normal growth factor network itself is a critical event in prostate cancer progression. If such transition points are proven, there are significant ramifications.
Ware
J L
JL
Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, USA. jlware@hsc.vcu.edu
D019295:Computational Biology; D018450:Disease Progression; D066246:ErbB Receptors / Q000378:metabolism / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000378:metabolism; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism / Q000502:physiology; D014407:Tumor Cells, Cultured
D006133:Growth Substances; D018974:Insulin-Like Growth Factor Binding Protein 4; D066246:ErbB Receptors; D017526:Receptor, IGF Type 1