title: Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San'o-shashin-to: a case report.
abstract: The following describes a 76-year-old male with obstructive sleep apnea syndrome successfully treated with a Kampo-formula, San'o-shashin-to (Formula medicamentorum tres ad dispellendi cordis). Polysomnography, performed before and after administration of San'o-shashin-to, revealed that the apnea index decreased from 11.1 events/hour to 4.1 events/hour, and that the apnea plus hypopnea index decreased from 18.4 events/hour to 10.7 events/hour. The patient was normo-weight (body mass index: 20.4 kg/m2), and events of sleep apnea and hypopnea were mostly noted during a non-rapid eye movement sleep. It is possible that San'o-shashin-to has some alleviating effects on the upper airway resistance during sleep.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hisanaga
authors.forename: O
authors.initials: O
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: A
authors.initials: A
authors.lastname: Okabe
authors.forename: H
authors.initials: H
authors.lastname: Tachibana
authors.forename: H
authors.initials: H
authors.lastname: Hagino
authors.forename: T
authors.initials: T
authors.lastname: Mita
authors.forename: I
authors.initials: I
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Tsutsumi
authors.forename: M
authors.initials: M
authors.lastname: Kurachi
authors.forename: T
authors.initials: T
authors.lastname: Itoh
mesh_terms: D000368:Aged; D001143:Arousal / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D017286:Polysomnography / Q000187:drug effects; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000209:etiology; D012894:Sleep Stages / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal