Recent advances in the solid phase synthesis of drug-like heterocyclic small molecules.
Phage display is a biological system which facilitates the cloning and rapid selection of peptides from large combinatorial libraries. In compa-rison to the chemical combinatorial approach, the advantages of phage display lie in its simplicity and replicability. While phage display has many diverse applications, this review will focus on the use of phage peptide libraries to discover epitopes recognised by monoclonal antibodies. As monoclonal antibodies are useful tools for the detection of proteins and for the investigation of molecular interactions, the identification of their epitopes will serve to elucidate the structure and function of proteins, as well as aid in the discovery of new drugs and the development of vaccines.
Andres
C J
CJ
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P. O. Box 5100, Wallingford, CT 06492-7660, USA. andresc@bms.com
Denhart
D J
DJ
Deshpande
M S
MS
Gillman
K W
KW
D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations