Drug-induced thrombocytopenia.
Many drugs can induce thrombocytopenia mediated by drug-dependent antiplatelet antibodies. Recent studies have documented specific epitopes for drug-dependent antibody binding on glycoprotein Ib-IX, glycoprotein IIb-IIIa, and platelet-endothelial cell adhesion molecule-1. Molecular identification of antibody binding sites may help to identify susceptible individuals. Management of patients with unexpected thrombocytopenia who are taking multiple drugs remains a difficult clinical problem. A recent systematic review of all published case reports of drug-induced thrombocytopenia ranks drugs according to the strength of clinical evidence for a causal relation to thrombocytopenia. This database is available online at http://moon.ouhsc.edu/jgeorge.
Rizvi
M A
MA
Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Shah
S R
SR
Raskob
G E
GE
George
J N
JN
D006801:Humans; D013921:Thrombocytopenia / Q000139:chemically induced / Q000276:immunology