title: Glucocorticoids and muscle catabolism.
abstract: Glucocorticoids inhibit protein synthesis and stimulate protein degradation in skeletal muscle and are an important factor in the development of muscle atrophy in various catabolic conditions. Glucocorticoid-stimulated muscle protein breakdown is primarily caused by ubiquitin-proteasome-dependent proteolysis although calcium-dependent protein degradation may also be involved. In certain catabolic conditions, including sepsis, an interaction between glucocorticoids and proinflammatory cytokines is important for the stimulation of muscle protein breakdown.
authors.affiliation: Department of Surgery, University of Cincinnati Medical Center, OH 45267-0558, USA. hasselp@email.uc.edu
authors.forename: P O
authors.initials: PO
authors.lastname: Hasselgren
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D003480:Cushing Syndrome / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D015870:Gene Expression; D005938:Glucocorticoids / Q000494:pharmacology*; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism* / Q000503:physiopathology; D046988:Proteasome Endopeptidase Complex; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D016207:Cytokines; D005938:Glucocorticoids; D009097:Multienzyme Complexes; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D005974:Glutamate-Ammonia Ligase