title: Role of serial tumor markers in the surveillance for recurrence in endometrial cancer.
abstract: The aim of this study is to evaluate the usefulness of tumor markers in the follow-up of patients with endometrial cancer. The sera of 23 patients with elevated pretreatment CA125, CA15.3, and CA19.9 were collected at each follow-up visit and analyzed. Eleven patients had normal posttreatment levels and none of them developed recurrence. Twelve patients had one or more increased tumor markers, 7 (58.3%) of them developed recurrence. Among these seven patients, six had CA125 elevated by at least 10-fold and one had elevated CA19.9. The median lead time between elevation of tumor markers and clinical evidence of recurrence was 6 months. Hence posttreatment elevation of CA125 is a useful predictor for recurrence in patients with elevated pretreatment levels.
authors.affiliation: Department of Obstetrics and Gynecology, University of Hong Kong.
authors.forename: S S
authors.initials: SS
authors.lastname: Lo
authors.forename: U S
authors.initials: US
authors.lastname: Khoo
authors.forename: D K
authors.initials: DK
authors.lastname: Cheng
authors.forename: T Y
authors.initials: TY
authors.lastname: Ng
authors.forename: L C
authors.initials: LC
authors.lastname: Wong
authors.forename: H Y
authors.initials: HY
authors.lastname: Ngan
mesh_terms: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D005260:Female; D006801:Humans; D018396:Mucin-1 / Q000097:blood; D011379:Prognosis; D012008:Recurrence
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D018396:Mucin-1