title: New genes potentially involved in breast cancer metastasis.
abstract: Identification of new genes involved in the pathogenesis of breast cancer opens new avenues for improved diagnostic markers and new molecular targets for improved treatment of this malignancy. In the following we review genes with proved involvement in invasion and metastasis of breast cancer as well as genes which exhibit an expression pattern that correlates with invasion and metastasis.
authors.affiliation: Roche Pharmaceuticals, Penzberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schwirzke
authors.forename: S
authors.initials: S
authors.lastname: Schiemann
authors.forename: A U
authors.initials: AU
authors.lastname: Gnirke
authors.forename: U H
authors.initials: UH
authors.lastname: Weidle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology; D010450:Endopeptidases / Q000235:genetics / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005796:Genes; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000473:pathology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D011480:Protease Inhibitors; D011487:Protein Conformation; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D012377:Rodentia; D015398:Signal Transduction / Q000235:genetics
chemical_list: D015815:Cell Adhesion Molecules; D018797:Cell Cycle Proteins; D016326:Extracellular Matrix Proteins; D006133:Growth Substances; D009363:Neoplasm Proteins; D011480:Protease Inhibitors; D017978:Receptors, Growth Factor; D016660:NAD(P)H Dehydrogenase (Quinone); D010450:Endopeptidases