Acute effect of nitric oxide on Raynaud's phenomenon in scleroderma.
Intra-arterial infusions of L-arginine and sodium nitroprusside significantly decreased the occurrence of laboratory-induced Raynaud's phenomenon in scleroderma patients. Raising the concentration of nitric oxide may be of therapeutic value in this population.
Freedman
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RR
Girgis
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R
Mayes
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MD
D000328:Adult; D001120:Arginine / Q000008:administration & dosage*; D003080:Cold Temperature; D005260:Female; D005385:Fingers / Q000098:blood supply; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D009599:Nitroprusside / Q000008:administration & dosage*; D011928:Raynaud Disease / Q000097:blood / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000097:blood / Q000188:drug therapy*; D014664:Vasodilation / Q000187:drug effects
D009599:Nitroprusside; D009569:Nitric Oxide; D001120:Arginine