title: Genetic engineering of doxorubicin production in Streptomyces peucetius: a review.
abstract: The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.
authors.affiliation: School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Hutchinson
authors.forename: A L
authors.initials: AL
authors.lastname: Colombo
mesh_terms: D000970:Antineoplastic Agents / Q000378:metabolism*; D003630:Daunorubicin / Q000096:biosynthesis / Q000378:metabolism; D004317:Doxorubicin / Q000096:biosynthesis*; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D003630:Daunorubicin