Amino acid-dependent signal transduction and insulin sensitivity.
Recent developments indicate that amino acids, in addition to their function as substrates for many metabolic pathways, can stimulate a signal transduction pathway that shares components with insulin-stimulated signalling cascades. Insulin sensitivity is dependent on the ambient amino acid concentration. Amino acid-dependent signal transduction is present in all insulin-sensitive tissues and in pancreatic beta cells. A defect in amino acid-dependent signal transduction may result in phenomena similar to those found in diabetes mellitus.
Meijer
A J
AJ
Department of Biochemistry, Academic Medical Center, University of Amsterdam, The Netherlands. a.j.meijer@amc.uva.nl
Sauerwein
H P
HP
D000596:Amino Acids / Q000502:physiology*; D000818:Animals; D007333:Insulin Resistance / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000596:Amino Acids