[Regulation of the contact sensitivity reaction by suppression of T gamma delta lymphocytes].
Contact sensitivity (CS) is a classical example of in vivo T cell mediated immune response that is under regulation. It is well known that in normal mice suppression of CS can be mediated by T alpha beta cells tolerized by prior exposure to high dose of antigen (Ag). In this paper it was shown that treatment of defective TCR alpha -/- or TCR beta -/- mice with high dose of Ag may result in induction of T gamma delta suppressor cells, that are able to inhibit both adoptive cell transfer of CS in vivo and IFN-gamma production in vitro. These suppressor cells are characterized as: TCR gamma delta+, CD3+, CD4-, CD8-, CD28+, CD40L+, CD95 (Fas)+, Fc gamma R+ and NK1.1-. Suppression mediated by T gamma delta cells showed antigen specificity, but was not restricted by the MHC. T gamma delta suppressor cells express very strong down-regulatory activity where even 2.5 x 10(3) T gamma delta cells could suppress 7 x 10(7) CS-effector cells. Presented data may suggest that IL-4 released by T gamma delta suppressor cells is involved in the mechanism of their down-regulatory function.
Szczepanik
M
M
Katedra Immunologii Collegium Medicum UJ w Krakowie.
D000222:Adaptation, Physiological; D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D015536:Down-Regulation; D000939:Epitopes / Q000276:immunology; D007108:Immune Tolerance; D051381:Rats; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000939:Epitopes; D016692:Receptors, Antigen, T-Cell, gamma-delta