Absorbed doses to patients from 191Pt-, 193mPt- and 195mPt-cisplatin.
Cisplatin, a chemotherapeutic drug, can be synthesized using radioactive platinum and then used for pharmacokinetic studies and tumor imaging. We have calculated the absorbed doses to various organs and tissues as well as the effective doses from 191Pt-, 193mPt- and 195mPt-cisplatin after administration to humans for diagnostic purposes. Liver was the organ that received the highest absorbed dose. The effective dose from 191Pt-, 193mPt- and 195mPt-cisplatin was 0.10 +/- 0.02, 0.17 +/- 0.04 and 0.23 +/- 0.05 mSv/MBq respectively.
Areberg
J
J
Department of Radiation Physics, Malmö University Hospital, Sweden. johan.areberg@rfa.mas.lu.se
Norrgren
K
K
Mattsson
S
S
D000042:Absorption; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002945:Cisplatin / Q000493:pharmacokinetics*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D010984:Platinum / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D011868:Radioisotopes; D011874:Radiometry / Q000379:methods; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D011868:Radioisotopes; D010984:Platinum; D002945:Cisplatin