[The clinico-metabolic characteristics of the course of a chlamydial infection in newborns].
A clinical and laboratory investigation was done in 68 full-term newborn babies, with clinical forms of Chlamydia infection having been identified. There have also been studied cellular and humoral links of immunity, hormonal profile, system of peroxidation, antioxidant defence. In Chlamydia infection in full-term newborns presenting with acute bronchopulmonary pathologies during the acute phase of the illness, signs are noted of activation of processes of free-radical lipid oxidation against the background of retardation of the antioxidant defense, with synthesis of hormones of the thyroidal, hypophyseal and adrenal systems being on the increase. Metabolic changes are directly related to immunologic responsiveness which is characterized by weakness of primary immune response. The degree the above changes make themselves known depend on the clinical form of Chlamydia-associated infection. The identified metabolic changes may be the basis of causative factors for change in capacity of newborn infants with chlamydial infection to adapt.
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D000208:Acute Disease; D000917:Antibody Formation; D002690:Chlamydia Infections / Q000097:blood* / Q000151:congenital / Q000175:diagnosis / Q000276:immunology; D002692:Chlamydia trachomatis; D005609:Free Radicals / Q000097:blood; D006728:Hormones / Q000097:blood; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D015227:Lipid Peroxidation
D005609:Free Radicals; D006728:Hormones