Six months of desipramine for dysthymia: can dysthymic patients achieve normal social functioning?
BACKGROUND
There is evidence that antidepressant medication improves social dysfunction during acute treatment in dysthymic patients but it is unknown if the gain in social functioning persists or progresses with longer-term antidepressant treatment. We examine the effect of 6 months of desipramine treatment on social functioning in dysthymic patients.


METHODS
Forty-six subjects with DSM-III-R dysthymia (70% with superimposed major depression) who had responded to 10 weeks of open-label desipramine (DMI) treatment received 16 additional weeks of continuation DMI. Social functioning was measured at weeks 0, 10 and 26 with the Social Adjustment Scale-Self Report.


RESULTS
Euthymia was maintained and a marginally significant trend for further improvement in overall social functioning appeared during continuation treatment. Only 24% of subjects achieved normative level of social adjustment after 6 months of DMI treatment.


CONCLUSIONS
The main limitation was the lack of a placebo control group.


CONCLUSIONS
Acute improvement in social functioning persists during continuation treatment. However, most dysthymic patients did not achieve a community level of social adjustment. Significant social dysfunction persists in dysthymic patients with low levels of depressive symptomatology after 6 months of intense DMI treatment.
Friedman
R A
RA
The New York Hospital, Cornell Medical Center, NY 10021, USA.
Markowitz
J C
JC
Parides
M
M
Gniwesch
L
L
Kocsis
J H
JH
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage* / Q000627:therapeutic use; D003891:Desipramine / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D019263:Dysthymic Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012919:Social Behavior; D016896:Treatment Outcome
D000929:Antidepressive Agents, Tricyclic; D003891:Desipramine