A case of ALK-positive large T-cell lymphoma expressing epithelial membrane antigen with favorable prognosis.
We describe the case of a 59-year-old woman with Ki-1-negative, T cell-type, anaplastic lymphoma kinase (ALK)-positive large cell lymphoma that was positive for epithelial membrane antigen. She was histopathologically diagnosed as having a metastatic undifferentiated carcinoma from a cervical lymph node biopsy. Clinical and radiographic studies revealed no other primary tumor. The patient underwent a left radical neck dissection. Surgically resected lymph nodes revealed an ALK1-positive large cell lymphoma. Thereafter the patient has had an unusually favorable prognosis.
Sawatsubashi
M
M
Department of Pathology, Saga Medical School, Department of Internal Medicine, Saga Medical School, Nabeshima, Saga, Japan. sawatsu@smsnet.saga-med.ac.jp
Fukushima
N
N
Satoh
T
T
Tsuda
K
K
Shin
T
T
Tokunaga
O
O
D000077548:Anaplastic Lymphoma Kinase; D000954:Antigens, Surface / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis / Q000201:enzymology / Q000556:secondary; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000276:immunology*; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000201:enzymology*; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000201:enzymology*; D008875:Middle Aged; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D020794:Receptor Protein-Tyrosine Kinases
D000954:Antigens, Surface; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases