title: Autistic regression with rolandic spikes.
abstract: OBJECTIVE
  This study was designed to further define the electroencephalographic abnormalities seen in the Landau-Kleffner syndrome variants and the associated clinical features.
  
  
  BACKGROUND
  Landau-Kleffner syndrome is rare, but its putative variants are more common.
  
  
  METHODS
  We report two patients with centro-temporal spikes, autistic epileptiform regression, and variably prominent oro-motor symptoms.
  
  
  RESULTS
  The epileptic aphasia pattern found among patients with prominent Rolandic spikes may more frequently involve expressive language than is seen in the typical Landau-Kleffner syndrome, where verbal auditory agnosia is the rule.
  
  
  CONCLUSIONS
  This clinical difference likely reflects the location of the epileptiform activity (centrotemporal as opposed to anterior or mid-temporal) on buccal-lingual function, vocalization, and language production.
authors.affiliation: New York University Medical Center, Department of Neurology, NYC 10016, USA. rn7@IS2.NYU.EDU
authors.forename: R
authors.initials: R
authors.lastname: Nass
authors.forename: O
authors.initials: O
authors.lastname: Devinsky
mesh_terms: D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D013702:Temporal Lobe / Q000503:physiopathology