title: Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.
abstract: A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.
authors.affiliation: Department of Chemistry, Wichita State University, KS 67260, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: Groutas
authors.forename: N M
authors.initials: NM
authors.lastname: Schechter
authors.forename: S
authors.initials: S
authors.lastname: He
authors.forename: H
authors.initials: H
authors.lastname: Yu
authors.forename: P
authors.initials: P
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Tu
mesh_terms: D053818:Chymases; D003499:Cyclic S-Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism*; D012867:Skin / Q000201:enzymology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003499:Cyclic S-Oxides; D004791:Enzyme Inhibitors; D013830:Thiadiazoles; D012697:Serine Endopeptidases; D053818:Chymases