The interaction between RTX toxins and target cells.
RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell types, and the leukotoxins, which are cell-type- and species-specific. These toxins offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.
Lally
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Leon Levy Research Center for Oral Biology, School of medicine, University of Pennsylvania, Philadelphia, PA 19104-6002, USA. lally@toxin.dental.upenn.edu
Hill
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Kieba
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Korostoff
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D000818:Animals; D017209:Apoptosis; D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D002462:Cell Membrane / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D005098:Exotoxins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D009336:Necrosis
D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; D006460:Hemolysin Proteins; C018579:leukotoxin