title: [Continuous inhalation administration of surfactant-BL for control of adult respiratory distress syndrome after reconstruction of the abdominal aorta].
abstract: A 62-year-old patient with Leriche's syndrome and critical ischemia of the low extremities has undergone the surgery of aortofemoral grafting. A patient has developed the severe ARDS on the second day of reperfusion (bilateral diffuse infiltrates, PO2/FiO2 < 100, lung injury score was 3). Different ways of administration of bovine surfactant (SURFACTANT BL, Russia) were used during the treatment. Total application time was 84 hours, total dose was 4000 mg (50 mg/kg). Considerable improvement of lung function occurred after start of the continuous inhalation of surfactant with a constant rate of 63 mg/h. Two hours after this step PO2/FiO2 reached 400 mm Hg and remained stable 12 hours more, up to the end of surfactant administration. The patient was soon successfully extubated and discharged on the 25th day after surgery. It is supposed that in spite of a small total dose of bovine surfactant the success was achieved due to an early start of the surfactant replacement, continuous inhalation and its definite rate.
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Shevchenko
authors.forename: O A
authors.initials: OA
authors.lastname: Rozenberg
authors.forename: G G
authors.initials: GG
authors.lastname: Khubulava
authors.forename: V V
authors.initials: VV
authors.lastname: Osovskikh
authors.forename: A E
authors.initials: AE
authors.lastname: Bautin
authors.forename: A A
authors.initials: AA
authors.lastname: Seĭliev
authors.forename: A B
authors.initials: AB
authors.lastname: Sazonov
authors.forename: V A
authors.initials: VA
authors.lastname: Krivtsov
authors.forename: V F
authors.initials: VF
authors.lastname: Khlebov
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002417:Cattle; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D007925:Leriche Syndrome / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D011663:Pulmonary Surfactants