title: Absorption prediction from physicochemical parameters.
abstract: Modern drug design not only focuses on the pharmacological activity of a compound but also considers its ability to be absorbed and to reach its site of action. The prediction of in vivo barrier permeabilities, particularly intestinal absorption and blood-brain barrier passage, are substantial concerns in the development of new drug compounds. For several decades, n-octanol-water partition coefficients dominated absorption prediction. In recent years, the basic physicochemical parameters describing both membrane permeability and lipophilicity have been established. This review provides an outline of some selected absorption-prediction models with emphasis on intestinal absorption.
authors.affiliation: Division of Physiology, GKT School of Biomedical Sciences, King's College London, Strand, London, UK WC2R 2LS.
authors.initials: SD
authors.lastname: Krämer