A novel K+ channel blocking toxin from Tityus discrepans scorpion venom.
A novel toxin (TdK1) was purified from the venom of the scorpion Tityus discrepans, sequenced and functionally characterized. It contains 37 amino acid residues and blocks reversible the shakerB K+ channel expressed in SF9 cells with a Kd in the order of 280 nM. The proposed systematic nomenclature for this peptide is alpha-KTx4.3.
D'Suze
G
G
Laboratory of Cellular Neuropharmacology, Biochemistry and Biophysics Center, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela. gdsuze@ivic.ivic.ve
Zamudio
F
F
Gómez-Lagunas
F
F
Possani
L D
LD
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D008970:Molecular Weight; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012604:Scorpion Venoms / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid; D051637:Shaker Superfamily of Potassium Channels
D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012604:Scorpion Venoms; D051637:Shaker Superfamily of Potassium Channels; C120911:alpha-KTx4.3 toxin