[Effect of partial hepatectomy on the invertor mechanism of regulation of the Na+,K+-ATPase activity in hepatocytes of rats of various ages].
Age peculiarities of partial hepatectomy effect on the hepatocytes plasma membrane Na+, K(+)-ATPase activity and its insulin-induced stimulation has been studied. It has been shown that partial hepatectomy does not change basal Na+, K(+)-ATPase activity in adult rats. In old partial hepatectomised rats Na+, K(+)-ATPase activity is slightly higher than in control old rats, although this increase is not statistically significant. At the same time, partial hepatectomy acts differently on the insulin-induced Na+, K(+)-ATPase activation in adult and old rats. Insulin activates Na+, K(+)-ATPase at the same extent both in control and partial hepatectomized adult animals. In old hepatectomized rats, but not in old control animals, insulin stimulates Na+, K(+)-ATPase activity as well as. Thus hepatectomy "rejuvenates" old hepatocytes and results in recovery of invertor mechanism of Na+, K(+)-ATPase activation.
Frol'kis
V V
VV
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv.
Kobzar'
A L
AL
Sokolova
O V
OV
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001481:Basal Metabolism; D002462:Cell Membrane / Q000502:physiology; D004789:Enzyme Activation; D006498:Hepatectomy; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013268:Stimulation, Chemical
D007328:Insulin; D000254:Sodium-Potassium-Exchanging ATPase