Schistosoma mansoni: IL-4 is necessary for concomitant immunity in mice.
To ask whether type-2 immune responses serve an essential role in concomitant immunity, that is the prevention of superinfection with Schistosoma mansoni, we compared resistance to a challenge infection in infected wild-type (WT) mice and in infected IL-4-/- mice, which are unable to mount Th2 responses during schistosomiasis. Although WT mice are protected from superinfection, resistance is abrogated in the absence of interleukin (IL)-4. We conclude that IL-4 or IL-4-dependent responses, or both, are necessary for resistance to S. mansoni superinfection in mice.
Brunet
L R
LR
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA.
Kopf
M A
MA
Pearce
E J
EJ
D000818:Animals; D007111:Immunity, Cellular; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D018448:Models, Immunological; D012555:Schistosomiasis mansoni / Q000276:immunology*; D015163:Superinfection; D018418:Th2 Cells
D015847:Interleukin-4