Defining the requirements for immunological control of mycobacterial infections.
Tuberculosis remains a major public health problem throughout the world. Research into the immunological basis of the host-pathogen relationship has recently benefited from the fascinating convergence of genetic data from mouse models and from humans. Latency - the seemingly quiescent phase of bacterial persistence - is the central problem in controlling tuberculosis and will be the next frontier of research.
Murray
P J
PJ
Dept of Infectious Diseases, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA. peter.murray@stjude.org
D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D009161:Mycobacterium / Q000502:physiology*; D009164:Mycobacterium Infections / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control
D016207:Cytokines