Neocrotocembranal from Croton oblongifolius.
A new cembranoid diterpene, neocrotocembranal (3), was isolated from the stem bark of Croton oblongifolius. Its structure was established on the basis of spectroscopic analysis. This compound inhibited platelet aggregation induced by thrombin, with an IC50 value of 47.21 microg/mL, and exhibited cytotoxicity against P-388 cells in vitro, with an IC(50) value of 6.48 microg/mL.
Roengsumran
S
S
Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
Singtothong
P
P
Pudhom
K
K
Ngamrochanavanich
N
N
Petsom
A
A
Chaichantipyuth
C
C
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D066298:In Vitro Techniques; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D019441:Plant Epidermis / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C400350:neocrotocembranal