title: Serum selenium levels and blood glutathione peroxidase activities in vitiligo.
abstract: It has recently been shown that patients with vitiligo can accumulate epidermal hydrogen peroxide (H2O2) in association with low catalase levels. This study examined serum selenium levels and blood glutathione peroxidase activities in 61 patients and controls. The results showed high serum selenium levels in 56% of the patients. As at least one isoform of glutathione peroxidase requires selenium for its activity, enzyme activities were also evaluated. The overall results were not significantly different compared with controls, but further age-related analysis of the data indicated significantly lower activities in patients up to 46 years. As glutathione peroxidase can also efficiently degrade H2O2, the results of this study could indicate an additional impaired H2O2 metabolism in vitiligo.
authors.affiliation: Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, BD7 1DP, UK.
authors.forename: W D
authors.initials: WD
authors.lastname: Beazley
authors.forename: D
authors.initials: D
authors.lastname: Gaze
authors.forename: A
authors.initials: A
authors.lastname: Panske
authors.forename: E
authors.initials: E
authors.lastname: Panzig
authors.forename: K U
authors.initials: KU
authors.lastname: Schallreuter
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012643:Selenium / Q000097:blood*; D014820:Vitiligo / Q000097:blood* / Q000201:enzymology
chemical_list: D006861:Hydrogen Peroxide; D005979:Glutathione Peroxidase; D012643:Selenium