title: Acylzirconocene Chloride as an "Unmasked" Acyl Anion: Enantioselective 1,2-Addition to alpha,beta-Unsaturated Ketone Derivatives.
abstract: The chiral monodentate phosphane ligand (R)-MOP facilitated the first enantioselective nucleophilic 1,2-addition of an "unmasked" acyl anion to a carbonyl group in the Pd(II)-catalyzed reaction of alpha,beta-unsaturated ketones with acylzirconocene chlorides [Eq. (1), 66 % ee, 88 % yield; (R)-MOP=(R)-2-(diphenylphosphanyl)-2'-methoxy-1,1'-binaphthyl].
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan).
authors.initials: Y
authors.lastname: Hanzawa
authors.initials: N
authors.lastname: Tabuchi
authors.initials: K
authors.lastname: Saito
authors.initials: S
authors.lastname: Noguchi
authors.initials: T
authors.lastname: Taguchi