Liposclerosing myxofibrous tumor: a radiologic-pathologic-distinct fibro-osseous lesion of bone with a marked predilection for the intertrochanteric region of the femur.
OBJECTIVE
To describe the characteristic features of liposclerosing myxofibrous tumor (LSMFT) of bone.


METHODS
The radiographs and clinical histories of 39 patients (21 male, 18 female; mean age, 42 years; age range, 15-69 years) with histologically verified LSMFT of bone were retrospectively studied.


RESULTS
LSMFT had a predilection for the proximal femur; more than 90% (30 of 33) of the femoral lesions were in the intertrochanteric region. Radiographs showed an indolent growth pattern with a well-defined and often extensively sclerotic margin. The bone contour either was normal or showed mild expansile remodeling. Mineralization within the lesion was not uncommon. Scintigrams showed mild to moderate focal tracer accumulation. Findings at computed tomography reflected those at radiography, whereas magnetic resonance imaging findings were nonspecific. Four (10%) patients had evidence of malignant transformation.


CONCLUSIONS
The radiologic appearance of LSMFT in the intertrochanteric region of the femur is characteristic. The substantial prevalence of malignant transformation associated with LSMFT underscores the need for close observation of this lesion.
Kransdorf
M J
MJ
Department of Radiology, Saint Mary's Hospital, Richmond, VA 23226, USA.
Murphey
M D
MD
Sweet
D E
DE
D000293:Adolescent; D000328:Adult; D000368:Aged; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology / Q000601:surgery; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005269:Femur / Q000473:pathology / Q000601:surgery; D005350:Fibroma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008067:Lipoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed