[The role of immunological mechanisms in the development of the late sequelae of nuclear disasters].
Effects, both specific and non-specific, were analysed of ionizing radiation in a comparative evaluation of medical sequels of the Chernobyl disaster and of the Semipalatinsk Range nuclear test. A hypothesis is advanced assuming that development of all major bodily morbid conditions is directly related to the dysfunction of certain complex of organs, the thyroid gland in the first place, the thymus gland known to be a central organ of systemic immunogenesis. A breach in the thymus link triggers harmful cascade reactions of neuroimmunoendocrinological regulation, appeared to be responsible for the pathogenesis of practically all pathologies disclosed.
Moskalenko
V F
VF
Vasil'ev
N V
NV
Mal'tsev
V I
VI
Shubik
V M
VM
Gorban'
E N
EN
Bobyleva
O A
OA
Drannik
G N
GN
Cherdyntseva
N V
NV
Koliada
T I
TI
Volianskiĭ
Iu L
IuL
D005786:Gene Expression Regulation / Q000276:immunology / Q000528:radiation effects; D006801:Humans; D009689:Nuclear Warfare; D011210:Power Plants; D011832:Radiation Injuries / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D018788:Radioactive Hazard Release; D012307:Risk Factors; D014586:USSR; D014455:Ukraine