title: Glioblastoma multiforme in a mature ovarian teratoma with recurring brain tumours.
abstract: OBJECTIVE
  We report a case study to highlight the occurrence of glioblastoma multiforme in an ovarian teratoma.
  
  
  RESULTS
  A 10-year-old girl presented with a left frontal lobe primitive neuroectodermal tumour which was successfully treated. After 6 uneventful years, she developed glioblastoma multiforme located posterior to the site of the initial tumour. Six years later, she presented with a mature cystic teratoma containing glioblastoma multiforme.
  
  
  CONCLUSIONS
  Glioblastoma in an ovarian teratoma is an exceptional event, which might have an initial clinical presentation as a metastatic brain tumour. Alternatively, recurring glial tumours may occur in a genetically predisposed person; the role of radiation and chemotherapy in this context remains to be elucidated.
authors.affiliation: Department of Pathology, Institut Gustave Roussy, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Yadav
authors.forename: A
authors.initials: A
authors.lastname: Lellouch-Tubiana
authors.forename: J C
authors.initials: JC
authors.lastname: Fournet
authors.forename: J E
authors.initials: JE
authors.lastname: Quazza
authors.forename: C
authors.initials: C
authors.lastname: Kalifa
authors.forename: C
authors.initials: C
authors.lastname: Sainte-Rose
authors.forename: F
authors.initials: F
authors.lastname: Jaubert
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005909:Glioblastoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D018242:Neuroectodermal Tumors, Primitive / Q000737:chemistry / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013724:Teratoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor