title: Silicon synaptic conductances.
abstract: We have developed compact analog integrated circuits that simulate two synaptic excitatory conductances. A four-transistor circuit captures the dynamics of an excitatory postsynaptic current caused by a real AMPA conductance. A six-transistor circuit simulates the effects of a real voltage-dependent NMDA conductance. The postsynaptic current dynamics are modeled by a current mirror integrator with adjustable gain. The voltage dependence of the silicon NMDA conductance is realized by a differential pair. We show the operation of these silicon synaptic conductances and their integration with the silicon neuron (Mahowald and Douglas, 1991).
authors.affiliation: Institut für Neuroinformatik (ETHZ/UNIZ), Zürich, Switzerland. chris@ini.phys.ethz.ch
authors.forename: C
authors.initials: C
authors.lastname: Rasche
authors.forename: R J
authors.initials: RJ
authors.lastname: Douglas
mesh_terms: D000200:Action Potentials / Q000502:physiology; D003202:Computers, Analog; D004553:Electric Conductivity; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D016571:Neural Networks, Computer; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D018091:Receptors, AMPA / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012825:Silicon; D013569:Synapses / Q000502:physiology*; D014173:Transistors, Electronic
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D012825:Silicon