title: In vitro antitrypanosomal activity of Moringa stenopetala leaves and roots.
abstract: The leaves and the root extracts of Moringa stenopetala were tested in vitro against trypomastigotes of Trypanosoma brucei, Trypanosoma cruzi and L. donovani amastigotes. The fresh root wood ethanol extract and the dried leaves acetone extract were found to be active against T. brucei with an ED(50) value of 9.2 microg/mL and 10.0 microg/mL respectively. All the other extracts were inactive against all the tested parasite forms.
authors.affiliation: Department of Biology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
authors.forename: Y
authors.initials: Y
authors.lastname: Mekonnen
authors.forename: V
authors.initials: V
authors.lastname: Yardley
authors.forename: P
authors.initials: P
authors.lastname: Rock
authors.forename: S
authors.initials: S
authors.lastname: Croft
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D006224:Cricetinae; D007893:Leishmania donovani / Q000302:isolation & purification*; D008647:Mesocricetus; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D018517:Plant Roots; D010945:Plants, Edible; D010946:Plants, Medicinal; D013154:Spleen / Q000469:parasitology; D014344:Trypanocidal Agents / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents