title: Prenatal diagnosis of hydronephrosis: impact on renal function and its recovery after pyeloplasty.
abstract: OBJECTIVE
  We reviewed our experience with corrective surgery for congenital ureteropelvic junction obstruction to assess the impact of mode of presentation on renal function at diagnosis and on postoperative recovery of function.
  
  
  METHODS
  We reviewed the records of consecutive children who underwent pyeloplasty or nephrectomy for ureteropelvic junction obstruction during a 5-year period at our hospitals. Patients were divided into those with and without a prenatal diagnosis of hydronephrosis. In each group we compared preoperative and postoperative differential renal function, as measured by nuclear renography.
  
  
  RESULTS
  We identified 89 patients, of whom 51 (57%) and 38 (43%) presented with prenatal and postnatal hydronephrosis, respectively. Kidneys in which hydronephrosis was diagnosed prenatally had better average differential renal function than those in which the condition was detected postnatally (45 versus 37%). This difference was even more significant in kidneys with less than 40% initial function (31 versus 21%). Presentation with a palpable mass was associated with worst renal function (mean 23%). Postoperatively renal function did not recover significantly in either group. There was a minimal increase in postoperative differential renal function in the subgroup of patients in whom initial differential renal function was less than 40%, although there was no significant difference in the 2 groups (6.5 versus 4.8%).
  
  
  CONCLUSIONS
  The early diagnosis of hydronephrosis provided by prenatal ultrasonography is associated with less obstructive nephropathy. Prolonged followup is necessary for studies of the natural history of hydronephrosis because relevant obstruction manifests clinically years later. Despite successful pyeloplasty function recovery is minimal in kidneys with poor function and hydronephrosis diagnosed prenatally. Our findings do not support previous observations that poor function markedly improves after obstruction is relieved.
authors.affiliation: Division of Pediatric Urology, Montreal Children's Hospital, McGill University Health Centre, Quebec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Capolicchio
authors.forename: M P
authors.initials: MP
authors.lastname: Leonard
authors.forename: C
authors.initials: C
authors.lastname: Wong
authors.forename: R
authors.initials: R
authors.lastname: Jednak
authors.forename: A
authors.initials: A
authors.lastname: Brzezinski
authors.forename: J L
authors.initials: JL
authors.lastname: Salle
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000175:diagnosis* / Q000601:surgery*; D007223:Infant; D007668:Kidney / Q000503:physiopathology*; D007682:Kidney Pelvis / Q000601:surgery*; D008297:Male; D011296:Prenatal Diagnosis; D014517:Ureteral Obstruction / Q000151:congenital* / Q000601:surgery*