[The relationship of the permeability coefficients of testosterone with solubility parameters of vehicles].
The effects of vehicles on the penetration through rat skin of testosterone were investigated. The solubilities of testosterone in various vehicles and the fluxes through rat abdomen skin had been determined. The solubility parameters of testosterone (delta i) and vehicles (delta v(n)) were calculated by Hildebrand's method. There was a good inverse parabola correlation between the log permeability coefficients (logp) and (delta v(n)). When delta v(n) approched delta i the permeability coefficients of testosterone approched the minimum as its limit.
Hu
F
F
Zhejiang Branch, CAMS, Hangzhou.
Liang
W
W
Shong
J
J
Wu
Q
Q
D000818:Animals; D010539:Permeability; D014677:Pharmaceutical Vehicles; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption; D012995:Solubility; D012997:Solvents; D013739:Testosterone / Q000493:pharmacokinetics*
D014677:Pharmaceutical Vehicles; D012997:Solvents; D013739:Testosterone