title: Calcium sulfate- and calcium phosphate-based bone substitutes. Mimicry of the mineral phase of bone.
abstract: Calcium sulfate and calcium phosphate have provided the orthopedic surgeon a viable alternative to autogenous bone grafting as either an osteoconductive bone void filler or a bone graft extender. These materials mimic the mineral phase of bone and are resorbed at a rate similar to the rate of bone formation. Thus, they are able to provide some structural support and prevent ingrowth of fibrous tissue while facilitating creeping substitution by the host bone.
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, California, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Tay
authors.forename: V V
authors.initials: VV
authors.lastname: Patel
authors.forename: D S
authors.initials: DS
authors.lastname: Bradford
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use; D001862:Bone Resorption / Q000503:physiopathology; D018786:Bone Substitutes / Q000737:chemistry* / Q000627:therapeutic use; D016025:Bone Transplantation; D002113:Calcification, Physiologic / Q000502:physiology; D002130:Calcium Phosphates / Q000737:chemistry* / Q000627:therapeutic use; D002133:Calcium Sulfate / Q000737:chemistry* / Q000627:therapeutic use; D003238:Connective Tissue / Q000502:physiology; D006801:Humans; D010012:Osteogenesis / Q000502:physiology; D014182:Transplantation, Autologous
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D002133:Calcium Sulfate