title: Delayed-onset ticlopidine-induced cholestatic jaundice.
abstract: An 86-year-old man experienced a rash approximately 2 weeks after starting ticlopidine therapy, necessitating discontinuation of the drug. About 1 month later, despite discontinuation, he developed jaundice and liver test abnormalities. These resolved gradually over the next few months. Based on case reports and the drug's pharmacokinetic profile, a high index of suspicion for ticlopidine-induced jaundice is prudent in patients with recent exposure to the agent who have evidence of liver damage.
authors.affiliation: Department of Pharmacy, Bronx VA Medical Center, New York 10468, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Kubin
authors.forename: O
authors.initials: O
authors.lastname: Sherman
authors.forename: K B
authors.initials: KB
authors.lastname: Hussain
authors.forename: L
authors.initials: L
authors.lastname: Feinman
mesh_terms: D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine