title: The role of high resolution ultrasound with guided cytology of groin lymph nodes in the management of squamous cell carcinoma of the vulva: a pilot study.
abstract: The accuracy of high resolution ultrasound with guided fine needle aspiration cytology in detecting inguinal lymph node involvement was assessed in 24 women undergoing radical vulvectomy and groin node dissection for squamous cell vulval cancer. Of the 43 groins dissected, ultrasound correctly diagnosed the lymph node status in 36, with five false positive and two false negative results. Cytology in 40 groins showed no false positive and five false negative results. The sensitivity and specificity for the combined techniques were 83% and 82% respectively. Assessed together, the combined technique failed to detect metastatic disease in two groins; in both cases the extent of nodal metastatic involvement was a solitary focus < 3 mm in diameter. The ultrasound and fine needle aspiration procedure is safe and well tolerated and can be repeated as needed for surveillance. The authors suggest that this procedure should be evaluated further to determine whether a policy of individual selection for lymphadenectomy can be implemented based on this technique.
authors.affiliation: Department of Radiology, Royal Marsden Hospital, London, UK.
authors.forename: E C
authors.initials: EC
authors.lastname: Moskovic
authors.forename: J H
authors.initials: JH
authors.lastname: Shepherd
authors.forename: D P
authors.initials: DP
authors.lastname: Barton
authors.forename: P A
authors.initials: PA
authors.lastname: Trott
authors.forename: N
authors.initials: N
authors.lastname: Nasiri
authors.forename: J M
authors.initials: JM
authors.lastname: Thomas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007264:Inguinal Canal; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*