title: Evaluation of the consolidation period during osteodistraction using computed tomography.
abstract: The use of distraction osteogenesis offers an alternative approach to the correction of craniofacial deformities. However, little is known with respect to the appropriate length of the consolidation period for the newly formed bone. The objective of this study was to evaluate, by quantitative computed tomography, the regenerate bone produced during osteodistraction of the dog mandible at three different consolidation times. Twelve skeletally mature male beagle dogs were equally separated into three experimental groups. Each dog underwent 10 mm of bilateral distraction osteogenesis to lengthen the mandible. After the distraction period, the bone was allowed to consolidate for 4, 6, or 8 weeks, at which time the animals were sacrificed and the mandibles harvested for computed tomographic imaging. The results demonstrate a significantly lower mean bone density of the regenerate in the 4 week group when compared with either the 6 or 8 week groups (P < .01). There was no significant difference, however, in mean bone density between the 6 and 8 week groups.
authors.affiliation: Department of Orthodontics, Texas A&M University System-Baylor College of Dentistry, Texas, USA.
authors.forename: S W
authors.initials: SW
authors.lastname: Smith
authors.forename: R C
authors.initials: RC
authors.lastname: Sachdeva
authors.forename: J B
authors.initials: JB
authors.lastname: Cope
mesh_terms: D000818:Animals; D015519:Bone Density; D001861:Bone Regeneration / Q000502:physiology; D004285:Dogs; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D019857:Osteogenesis, Distraction / Q000295:instrumentation; D017063:Outcome Assessment, Health Care / Q000379:methods; D011184:Postoperative Period; D014057:Tomography, X-Ray Computed