Triterpenoid saponins from Ilex kudincha.
Ten new triterpene saponins, ilekudinosides A-J (2, 6-8, 10, 13-17), together with seven known triterpene saponins, ilexoside XLVIII (1); cynarasaponin C (5); latifolosides A (9), C (3), G (12), and H (4); and kudinoside G (11), were isolated from an aqueous extract of the leaves of Ilex kudincha. They possessed oleanane- and ursane-type triterpenoids as the aglycons. The structures were elucidated by 1D and 2D NMR experiments, including ROE difference, HOHAHA difference, 1H-1H COSY, and 1H-13C COSY (HMQC, HMBC) methods and sugar analysis. Compounds 1 and 5 exhibited acyl CoA cholesteryl acyl transferase (ACAT) inhibitory activity.
Nishimura
K
K
R&D Institute of Health Science, Kayaku Co. Ltd., 560 Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan.
Miyase
T
T
Noguchi
H
H
D002240:Carbohydrate Sequence; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D007564:Japan; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D002785:Sterol O-Acyltransferase