title: Fundoplication provides effective and durable symptom relief in patients with Barrett's esophagus.
abstract: BACKGROUND
  Columnar-lined esophagus with intestinal metaplasia (IM), also called Barrett's esophagus, is a manifestation of severe gastroesophageal reflux (GER) and may predict poor symptom relief and high failure rate after fundoplication. We compared symptom scores and reoperation rates in GER patients with and without Barrett's esophagus.
  
  
  METHODS
  Between July 1992 and July 1997, 646 patients underwent fundoplication (626 laparoscopic). Of 150 endoscopic biopsies of suspected columnar-lined esophagus, 80 confirmed IM, 50 identified cardiac or fundic epithelium, and 20 revealed only esophagitis. Typical GER symptoms were scored by patients preoperatively and postoperatively (0 to 4 scale). We compared symptom response (Wilcoxon rank sum test) and failure rates (t test) in patients with IM and GER controls without IM. Preoperative data were available for 74 IM patients and 496 controls. One-year follow-up was available in 45 IM patients and 301 controls. Intermediate follow-up (2 to 5 years) was available in 20 IM patients and 99 controls.
  
  
  RESULTS
  Preoperatively and postoperatively, patients with IM reported heartburn, regurgitation, and dysphagia scores similar to controls. Procedure failure, requiring redo fundoplication, appeared more likely in IM patients than controls (6.3% versus 2.5%), but this difference did not reach statistical significance (P = 0.061).
  
  
  CONCLUSIONS
  Fundoplication provides equivalent symptom relief for patients with and without IM.
authors.affiliation: Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Farrell
authors.forename: C D
authors.initials: CD
authors.lastname: Smith
authors.forename: R E
authors.initials: RE
authors.lastname: Metreveli
authors.forename: A B
authors.initials: AB
authors.lastname: Johnson
authors.forename: K D
authors.initials: KD
authors.lastname: Galloway
authors.forename: J G
authors.initials: JG
authors.lastname: Hunter
mesh_terms: D001471:Barrett Esophagus / Q000150:complications / Q000473:pathology / Q000601:surgery*; D003680:Deglutition Disorders; D005500:Follow-Up Studies; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000473:pathology / Q000601:surgery*; D006356:Heartburn; D006801:Humans; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome