[Apoptosis and gamma rays].
Gamma radiation can induce cell death in lymphocytes. Apoptosis is characterized by numerous morphological, biochemical and molecular modifications measurable using various methods. Some radioprotectors have antioxidant properties and are able to inhibit radiation-induced DNA fragmentation and caspase activation. There are several caspases that cleave proteolytically many proteins and trigger phosphatidylserine externalization recognized by phagocytes. Three main proteins are involved in the regulation of radiation-induced apoptosis: p53, Fas and Bcl-2. The pharmacological regulation of cell death is discussed in order to investigate the subsequent effects related to cell regeneration following radiation injury.
Mathieu
J
J
Département de Radiobiologie et de Radiopathologie, Centre de Recherches du Service de Santé des Armées, La Tronche.
Richard
S
S
Ballester
B
B
Chancerelle
Y
Y
Multon
E
E
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011837:Radiation-Protective Agents / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D019253:Proto-Oncogene Proteins c-bcl-2; D011837:Radiation-Protective Agents; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor