title: Inhaled nitric oxide reduces pulmonary artery pressures in portopulmonary hypertension.
abstract: Pulmonary artery hypertension in association with liver failure (portopulmonary hypertension [PPHTN]) is a significant barrier to liver transplantation because patients with this condition have a very high mortality when transplantation is undertaken. Inhaled nitric oxide (NO), a potent pulmonary vasodilator, reduces pulmonary artery pressure (PAP) in some patients with primary pulmonary hypertension, but its effect in patients with PPHTN is controversial. We investigated the hemodynamic effects of inhaled NO in 6 patients with PPHTN. Five of 6 patients responded to NO inhalation with decreases in PAP and pulmonary vascular resistance of greater than 10%; these decreases were statistically significant at NO concentrations of 10 and 30 ppm. Cardiac output did not significantly change. We conclude that inhalation of NO reduces PAPs in some patients with PPHTN.
authors.affiliation: Department of Anesthesiology, Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Findlay
authors.forename: B A
authors.initials: BA
authors.lastname: Harrison
authors.forename: D J
authors.initials: DJ
authors.lastname: Plevak
authors.forename: M J
authors.initials: MJ
authors.lastname: Krowka
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001784:Blood Gas Analysis; D006328:Cardiac Catheterization; D000075202:Contraindications; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy; D011669:Pulmonary Wedge Pressure / Q000187:drug effects*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide