title: [Diagnosis of malignant and benign insulinoma. Experience of the National Institute of Nutrition].
abstract: BACKGROUND
  Insulinomas are uncommon tumors, their incidence is approximately one case for 1 million population per year.
  
  
  OBJECTIVE
  To expose our experience in the diagnosis of these tumors at the Instituto Nacional de la Nutrición Salvador Zubirán.
  
  
  METHODS
  All patients with histologic diagnosis of insulinoma were reviewed; the period was from 1959 to 1996. The methods used for diagnosis and localization as well as the clinical picture according to the benignity or malignity of the tumor were registered.
  
  
  RESULTS
  Eighteen patients were included, four of them with malignant tumors. In two patients islet cell tumors occurred in association with MEN type I, one of them benign and the other malignant. The mean age of patients with benign tumor was 38.2 +/- 13.5 years, in those with malignant tumors it was 51.5 +/- 16.2 years. The median period between symptoms and diagnosis was 34.4 +/- 15 months for benign tumors and 6 +/- 1.1 months for those with malignant tumors (p = 0.02). Patients with increasing weight had benign tumors. The 24 hours fasting test was not done in patients with malignant tumors because of the severity of hypoglycemia. The insulin/glucose ratio in patients with a malignant tumor was 5.2 +/- 4.7, while in patients with a benign tumor it was 1.82 +/- 1.7. The imaging studies showed that three patients with malignant tumors had hepatic metastasis and one had lymph node metastasis. The low accuracy of localization by radiological methods is due to the size of the tumor (> 2 cm).
  
  
  CONCLUSIONS
  Malignant insulinomas are more aggressive and the delay of diagnosis is shorter that in cases with benign tumors. Selective arteriography remains the best preoperative localization procedure.
authors.affiliation: Departamento de Endocrinología del Instituto Nacional de la Nutrición Salvador Zubirán (INNSZ), México, D.F.
authors.forename: J C
authors.initials: JC
authors.lastname: López Alvarenga
authors.forename: N
authors.initials: N
authors.lastname: Cáceres Agreda
authors.forename: L
authors.initials: L
authors.lastname: Rivera
authors.forename: A
authors.initials: A
authors.lastname: Gamboa
authors.forename: F J
authors.initials: FJ
authors.lastname: Gómez Pérez
authors.forename: J A
authors.initials: JA
authors.lastname: Rull
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis; D000328:Adult; D005260:Female; D006077:Government Agencies; D006801:Humans; D007340:Insulinoma / Q000175:diagnosis*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis*