Preparation and properties of glutaraldehyde cross-linked whey protein-based microcapsules containing theophylline.
Whey protein-based microcapsules containing a model drug, theophylline, were prepared in organic phase, using glutaraldehyde-saturated toluene. In all cases, spherical microcapsules, ranging from <400 to 1000 microm in diameter, were obtained. Results indicated that core crystals were embedded throughout the wall matrix. In all cases, retention efficiency of theophylline was higher than 74% and was not affected by cross-linking conditions. Results of theophylline release in simulated intestinal and gastric fluids at 37 degrees C indicated that the diffusion-governed core release was significantly affected by size of microcapsules, cross-linking conditions, and by type of dissolution medium. In all cases, core release in simulated intestinal fluid was faster than in simulated gastric fluid.
Lee
S J
SJ
Department of Food Science and Technology, University of California, Davis, CA 95616, USA.
Rosenberg
M
M
D002214:Capsules; D005976:Glutaral; D008855:Microscopy, Electron, Scanning; D008894:Milk Proteins / Q000008:administration & dosage*; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry; D000067816:Whey Proteins
D002214:Capsules; D008894:Milk Proteins; D000067816:Whey Proteins; D013806:Theophylline; D005976:Glutaral