Molecular remission in adult T cell leukemia after autologous CD34+ peripheral blood stem cell transplantation.
This report describes a patient with acute-type adult T cell leukemia/lymphoma (ATLL) successfully treated by autologous CD34+ peripheral blood stem cell transplantation after fractionated total body irradiation and high-dose cytarabine and cyclophosphamide. A newly established inverse polymerase chain reaction method was used to demonstrate the disappearance of ATLL clonal cells. The patient achieved a sustained molecular remission after transplantation, but died from opportunistic infection 4 months after transplantation. Thus, autologous CD34+ peripheral blood stem cell transplantation is promising for this type of malignancy. However, a prudent clinical attitude toward immunological fragility after transplantation is needed for better outcome.
Nakane
M
M
Bone Marrow Transplantation Team, Tokyo Metropolitan Komagome Hospital, Japan.
Ohashi
K
K
Sato
Y
Y
Moriya
A
A
Inoue
T
T
Mori
S
S
Tanikawa
S
S
Akiyama
H
H
Maeda
Y
Y
Sasaki
T
T
Karasawa
K
K
Okuyama
Y
Y
Hiruma
K
K
Sakamaki
H
H
D018952:Antigens, CD34; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015458:Leukemia, T-Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D014411:Neoplastic Stem Cells; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D014182:Transplantation, Autologous
D018952:Antigens, CD34