Histopathologic study of presumed parafoveal telangiectasis.
OBJECTIVE
To report the postmortem histopathologic features that closely resemble the clinical features of parafoveal telangiectasis.


METHODS
Light and electron microscopy.


RESULTS
Histopathologic features included macular edema; telangiectatic vessels; retinal, subretinal, and superficial retinal neovascularization; retinal pigment epithelial hyperplasia around neovascular aggregates; retinal-choroidal vascular anastomosis; and superficial pigmented cells with lipofuscin.


CONCLUSIONS
The postmortem histopathologic findings in a 36-year-old woman with Down syndrome and other systemic conditions correlate with features noted in previous reports of presumed parafoveal telangiectasis.
Eliassi-Rad
B
B
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Green
W R
WR
D000328:Adult; D001159:Arterio-Arterial Fistula / Q000209:etiology / Q000473:pathology; D002829:Choroid / Q000098:blood supply / Q000648:ultrastructure; D004314:Down Syndrome / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D005584:Fovea Centralis / Q000098:blood supply* / Q000648:ultrastructure; D006801:Humans; D008269:Macular Edema / Q000209:etiology / Q000473:pathology; D012161:Retinal Artery / Q000002:abnormalities; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology*; D015861:Retinal Neovascularization / Q000209:etiology / Q000473:pathology; D013684:Telangiectasis / Q000150:complications / Q000473:pathology*