An airbone mold-derived product, beta-1,3-D-glucan, potentiates airway allergic responses.
Repeated inhalation of allergen leads to the down-regulation of allergen-specific IgE responses in non-atopic individuals as well as in mice. This phenomenon is named inhalation-induced IgE tolerance. In contrast, inhaled allergen causes significant IgE and allergic responses in atopic persons. The mechanisms involved in this differential regulation of airway allergen-specific immune responses remain unclear. Besides the allergen exposure of genetically susceptible individuals, environmental contamination is considered to play a role as an initiating factor for airway allergic responses. Using a murine model, we demonstrate here that airborne beta-1, 3-D-glucan, which exists frequently in our environment, particularly in highly humid areas, can abrogate inhalation-induced IgE isotype-specific down-regulation and promote airway eosinophil infiltration to inhaled antigen.
Wan
G H
GH
Graduate Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
Li
C S
CS
Guo
S P
SP
Rylander
R
R
Lin
R H
RH
D000280:Administration, Inhalation; D000485:Allergens / Q000008:administration & dosage*; D000818:Animals; D000946:Antigens, Fungal / Q000008:administration & dosage; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D005936:Glucans / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016753:Interleukin-10 / Q000235:genetics; D018664:Interleukin-12 / Q000235:genetics; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D047071:beta-Glucans
D000485:Allergens; D000946:Antigens, Fungal; D017931:DNA Primers; D005936:Glucans; D007074:Immunoglobulin G; D012333:RNA, Messenger; D047071:beta-Glucans; D016753:Interleukin-10; D018664:Interleukin-12; D007073:Immunoglobulin E; D010047:Ovalbumin; C033363:beta-1,3-glucan