title: Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds.
abstract: Efficient syntheses of ent-isozonarol (6a), ent-isozonarone (7a) and ent-chromazonarol (8) from (-)-sclareol (12) are described. 6a and 7a show a significative antitumoral activity.
authors.affiliation: Instituto de Biotecnologia, Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain. afbarre@goliat.ugr.es
authors.forename: A F
authors.initials: AF
authors.lastname: Barrero
authors.forename: E J
authors.initials: EJ
authors.lastname: Alvarez-Manzaneda
authors.forename: M M
authors.initials: MM
authors.lastname: Herrador
authors.forename: R
authors.initials: R
authors.lastname: Chahboun
authors.forename: P
authors.initials: P
authors.lastname: Galera
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D014966:Xanthenes; C121655:chromazonarol