title: [Binding affinity to steroid hormone receptors and antiproliferative action on MCF-7 cells of coumarin derivatives and isoflavonoids].
abstract: The study of the relative binding affinity to steroïd hormonal receptors and of the antiproliferative action on MCF-7 cells of 3-arylcoumarines, 3-aryl-4-hydroxycoumarines, isoflavanones, isoflavan-4-ols and isoflavones, indicates a weak activity in the case of some representatives of coumarines.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, Chatenay-Malabry.
authors.forename: S
authors.initials: S
authors.lastname: Kirkiacharian
authors.forename: H
authors.initials: H
authors.lastname: Chidiack
authors.forename: D
authors.initials: D
authors.lastname: Philibert
authors.forename: P
authors.initials: P
authors.lastname: Van De Velde
authors.forename: F
authors.initials: F
authors.lastname: Bouchoux
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects; D003374:Coumarins / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000493:pharmacokinetics / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D013329:Structure-Activity Relationship; D013950:Thymus Gland / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D003374:Coumarins; D007529:Isoflavones; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D011994:Recombinant Proteins