title: [Brain perfusion changes after head trauma assessed by cerebral SPECT with aminophylline test].
abstract: Tomographic cerebral blood flow SPECT scanning using Tc-99m-HMPAO was performed before and after i.v. administration of aminophylline in 36 patients between 6 months to 11 years after closed head trauma. Asymmetries of brain perfusion were found in 34 patients, normal rCBF distribution in 2 patients. Bi-focused asymmetries on the presumed line: trauma-contra coup were seen in 64% of the patients. In 70.4% of the patients with brain perfusion asymmetries the CT scan was normal. The aminophylline test improved the perfusion in 42% of the patients, indicating preserved perfusion reserve. Persistence of brain perfusion alterations after head trauma exists. Aminophylline test may be useful in the assessment of brain perfusion reserve in post-traumatic focus. Brain perfusion SPECT scans may be useful for medico-legal purposes.
authors.affiliation: Oddziału Neurologicznego Szpitala Marynarki Wojennej w Gdańsku.
authors.forename: P
authors.initials: P
authors.lastname: Lyczak
authors.forename: P
authors.initials: P
authors.lastname: Lass
authors.forename: M
authors.initials: M
authors.lastname: Sygitowicz
authors.forename: E
authors.initials: E
authors.lastname: Stepień-Koćmiel
authors.forename: E
authors.initials: E
authors.lastname: Mierzejewska
authors.forename: T
authors.initials: T
authors.lastname: Bandurski
authors.forename: G
authors.initials: G
authors.lastname: Romanowicz
mesh_terms: D000086:Acetazolamide / Q000493:pharmacokinetics*; D000328:Adult; D000628:Aminophylline / Q000493:pharmacokinetics*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001930:Brain Injuries / Q000175:diagnosis*; D002257:Carbonic Anhydrase Inhibitors / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D010726:Phosphodiesterase Inhibitors; D019275:Radiopharmaceuticals; D000628:Aminophylline; D019690:Technetium Tc 99m Exametazime; D000086:Acetazolamide