title: Design of peptides derived from anti-IgE antibody for allergic treatment.
abstract: We have designed and synthesized peptides derived from an anti-IgE antibody which has a potential for the treatment of allergy. It was indicated that conformational restriction of peptide via an intramolecular disulfide bond improved the binding affinity for IgE and that the peptide might have an ability to inhibit the IgE-receptor interaction.
authors.affiliation: Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ohgitani
authors.forename: A
authors.initials: A
authors.lastname: Ueno
authors.forename: H
authors.initials: H
authors.lastname: Mihara
mesh_terms: D018926:Anti-Allergic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D007073:Immunoglobulin E / Q000276:immunology; D007135:Immunoglobulin Variable Region / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000378:metabolism / Q000627:therapeutic use; D017455:Receptors, IgE / Q000037:antagonists & inhibitors
chemical_list: D018926:Anti-Allergic Agents; D000888:Antibodies, Anti-Idiotypic; D007135:Immunoglobulin Variable Region; D010455:Peptides; D017455:Receptors, IgE; C026408:anti-IgE antibodies; D007073:Immunoglobulin E