Possible discrepancies between dicentric chromosome frequencies and recorded ionizing radiation doses: in vivo study.
BACKGROUND
The available data on the effects of radiation on humans are limited to the reports of accidental exposure or studies of patients under diagnostic and therapeutic treatment; few reports refer to a occupationally exposed population groups.


METHODS
The research was conducted on 66 subjects employed in the Department of Nuclear Medicine and 41 nonemployed controls. For each of them chromosomal analysis and gamma-spectrometer analysis of 24-hour urine were carried out. Exposure doses were measured using film-badge dosimetry.


RESULTS
The comparison of dosimetric data obtained by film-badge measurements and the frequency of dicentric chromosomes in each subject revealed no correlation between the two observed parameters.


CONCLUSIONS
In view of the above results, the subjects should be studied within job/task groups as they are far more likely to receive comparable doses.
Kubelka
D
D
Institute for Medical Research and Occupational Health, Zagreb, Ksaverska c 2, Croatia. dragan.kubelka@hzzz.hr
Garaj-Vrhovac
V
V
Hebrang
A
A
Simpraga
M
M
D000328:Adult; D002842:Chromatids / Q000235:genetics / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000235:genetics*; D019457:Chromosome Breakage / Q000235:genetics; D002875:Chromosomes / Q000737:chemistry / Q000235:genetics / Q000528:radiation effects* / Q000648:ultrastructure; D005260:Female; D005373:Film Dosimetry; D006801:Humans; D008297:Male; D009684:Nuclear Medicine Department, Hospital; D016273:Occupational Exposure; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D019275:Radiopharmaceuticals / Q000652:urine; D012907:Smoking; D013051:Spectrometry, Gamma; D013997:Time Factors
D019275:Radiopharmaceuticals