Dichlorodiaportin, diaportinol, and diaportinic acid: three novel isocoumarins from penicillium nalgiovense
Three novel isocoumarin (or isochromen) metabolites, dichlorodiaportin [3-(3, 3-dichloro-2-hydroxy-propyl)-8-hydroxy-6-methoxy-isochromen-1-one] (1), diaportinol [3-(2, 3-dihydroxy-propyl)-8-hydroxy-6-methoxy-isochromen-1-one] (2), and diaportinic acid [2-hydroxy-3-(8-hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)-propanoic acid] (3), were isolated from the cultures of Penicillium nalgiovense along with citreoisocoumarin (4) and 6-methyl-citreoisocoumarin (5). Their structures were elucidated by spectroscopic methods including UV, MS, and NMR.
Larsen
TO
Mycology Group, Department of Biotechnology, 221, Technical University of Denmark, 2800 Lyngby, and Novo Nordisk A/S, Novo Nordisk Park, 2760 Malov, Denmark.
Breinholt
J