title: Pax 6: mastering eye morphogenesis and eye evolution.
abstract: Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis. It is proposed that the various eye-types found in metazoa are derived from a common prototype, monophyletically, by a mechanism called intercalary evolution.
authors.affiliation: Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland. gehring@ubaclu.unibas.ch
authors.forename: W J
authors.initials: WJ
authors.lastname: Gehring
authors.forename: K
authors.initials: K
authors.lastname: Ikeo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D004268:DNA-Binding Proteins / Q000235:genetics*; D005123:Eye / Q000254:growth & development*; D005136:Eye Proteins / Q000235:genetics*; D018398:Homeodomain Proteins; D006801:Humans; D008969:Molecular Sequence Data; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D017386:Sequence Homology, Amino Acid
chemical_list: D004268:DNA-Binding Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins