title: Gluten-free diet decreases urinary peptide levels in children with celiac disease.
abstract: BACKGROUND
  Increased urine secretion of peptides has been found in celiac disease, probably resulting from increased intestinal uptake of peptides caused by damage to the small gut mucosa.
  
  
  METHODS
  High-performance liquid chromatography of low-molecular-weight peptides in the urine was performed over 6 months, before and after a gluten-free diet was instituted in children who clinically improved while consuming the diet.
  
  
  RESULTS
  A significant decrease of peptide levels was observed in children consuming the gluten-free diet. Certain peptide peaks thought to be gluten related decreased the most after the patients began the diet.
  
  
  CONCLUSIONS
  Because the peptides decrease in patients consuming a gluten-free diet, it is reasonable to conclude that such peptides have a mostly dietary origin.
authors.affiliation: Department of Pediatrics, Buskerud Central Hospital, Drammen, Norway.
authors.forename: J
authors.initials: J
authors.lastname: Ek
authors.forename: M
authors.initials: M
authors.lastname: Stensrud
authors.forename: K L
authors.initials: KL
authors.lastname: Reichelt
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000178:diet therapy* / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005903:Gliadin / Q000652:urine; D005983:Glutens / Q000008:administration & dosage* / Q000652:urine; D006801:Humans; D008970:Molecular Weight; D010455:Peptides / Q000652:urine*
chemical_list: D010455:Peptides; D005983:Glutens; D005903:Gliadin