The potential of molecular screening.
Clonal genetic alterations such as tumor suppressor, gene mutations, or microsatellite instability are a hallmark of human cancer. These genetic alterations can be detected in clinical samples using DNA amplification techniques and used for early detection of cancer. This article reviews molecular-based approaches for screening of malignancies commonly encountered by the practicing general surgeon.
Ahrendt
S A
SA
Department of Surgery, The Medical College of Wisconsin, Milwaukee, Wisconsin 53326, USA.
Sidransky
D
D
D014408:Biomarkers, Tumor / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D018895:Microsatellite Repeats / Q000235:genetics; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm