Lack of in vitro antimicrosporidian activity of thalidomide.
Thalidomide was evaluated for its in vitro activity against Encephalitozoon species by using the MRC-5 cell system. A cytotoxic effect was observed for concentrations of 10(1) microg/ml (P < 10(5)) and 5 microg/ml (P < 10(5)). Thalidomide did not significantly inhibit the growth of any of the microsporidia under study. These data suggest that thalidomide is not an etiologic treatment in microsporidial enteritis.
Ridoux
O
O
Unité des Rickettsies, CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
Drancourt
M
M
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000704:Analysis of Variance; D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D016819:Encephalitozoon / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D016890:Encephalitozoonosis / Q000188:drug therapy; D015658:HIV Infections / Q000150:complications; D015497:HIV-1; D006801:Humans; D013792:Thalidomide / Q000494:pharmacology* / Q000627:therapeutic use
D019380:Anti-HIV Agents; D013792:Thalidomide