title: Neuroimaging findings of four patients with Sandhoff disease.
abstract: Sandhoff disease is a severe form of GM2 gangliosidosis that is caused by the deficiency of both hexosaminidase A and B. Startle reaction, hypotonia, psychomotor retardation, and blindness are the main clinical features. Presented are computed tomography and magnetic resonance imaging findings of four patients with Sandhoff disease diagnosed by enzymatic analyses. Bilateral homogeneous thalamic hyperdensity was evident on computed tomography. Magnetic resonance imaging scans revealed mild cortical atrophy, a thin corpus callosum, and abnormal signal intensities in the caudate nucleus, globus pallidum, putamen, cerebellum, and brainstem. No correlation was evident between the severity of the central nervous system imaging findings and the clinical pictures. In this article the neuroimaging findings of four patients with Sandhoff disease are discussed.
authors.affiliation: Department of Genetics, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yüksel
authors.forename: C
authors.initials: C
authors.lastname: Yalçinkaya
authors.forename: C
authors.initials: C
authors.lastname: Işlak
authors.forename: E
authors.initials: E
authors.lastname: Gündüz
authors.forename: M
authors.initials: M
authors.lastname: Seven
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012497:Sandhoff Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000201:enzymology; D014057:Tomography, X-Ray Computed