Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode.
The electrochemical reduction of ornidazole was studied at a glassy carbon electrode activated by applying a new pretreatment. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the solvent (aqueous media, mixed aqueous-organic systems) and surfactant was investigated. Linear calibration plots were obtained over the concentration ranges 4x10(-6)-6x10(-4) and 6x10(-6)-6x10(-4) mol l(-1) in 0.2 M H(2)SO(4) and acetate buffer (pH 4.7), respectively. The method was applied to the determination of ornidazole in different drug formulations.
Özkan
SA
Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Ankara, Turkey
Senturk
Z
Biryol
I