title: IgA-gliadin antibodies, IgA-containing circulating immune complexes, and IgA glomerular deposits in wasting marmoset syndrome.
abstract: BACKGROUND
  Marmosets in captivity are highly susceptible to wasting marmoset syndrome (WMS), the aetiology of which is still not fully determined.
  
  
  METHODS
  The level of IgA-gliadin antibodies (IgA-AGA), of IgA-containing circulating immune complexes (IgA-CIC), and the degree of glomerular IgA deposits were compared between marmosets suffering from WMS and animals not affected by the disorder.
  
  
  RESULTS
  Both IgA-AGA and IgA-CIC were demonstrable in all groups of monkeys investigated. IgA-AGA and IgA-CIC were significantly higher in monkeys with WMS than in non-affected animals. There was a significant correlation between the glomerular IgA-deposition and titre of IgA-AGA. The group of marmosets strongly positive for glomerular IgA deposits comprised significantly more animals suffering from WMS than the group without deposits. In the diet of the animals a considerable amount of gliadin-like cereal proteins was assayed.
  
  
  CONCLUSIONS
  There are several parallels between the human disorders (coeliac disease and IgA-nephropathy/Berger's disease) and the changes observed in WMS. It should be further investigated if WMS in marmosets is a suitable animal model for both human diseases.
authors.affiliation: German Primate Centre, Göttingen.
authors.forename: C
authors.initials: C
authors.lastname: Schroeder
authors.forename: A A
authors.initials: AA
authors.lastname: Osman
authors.forename: D
authors.initials: D
authors.lastname: Roggenbuck
authors.forename: T
authors.initials: T
authors.lastname: Mothes
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000276:immunology*; D002144:Callithrix; D005260:Female; D005903:Gliadin / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis*; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D012016:Reference Values; D019282:Wasting Syndrome / Q000276:immunology*
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D005903:Gliadin