High levels of GM(1)-ganglioside and GM(1)-ganglioside beta-galactosidase in the parotid gland: a new model for secretory mechanisms of the parotid gland.
A new model for the subcellular basis of parotid secretion is presented in this article. GM(1)-ganglioside, typically found in neural tissues, is shown to be abundant in the parotid gland. This ganglioside may play a central role in membrane turnover mechanisms underlying exocytosis/endocytosis in its role as a promoter of membrane fusion or a fusogen. The lysosome and lysosomal hydrolases also play a central role in this model in catabolism of GM(1)-ganglioside. Consequently, high levels of the lysosomal hydrolase acidic beta-galactosidase are demonstrated in the salivary gland. GM(1)-gangliosidosis of the parotid glands, as described in mice, appears to be the first single-gene heritable disease found so far in the salivary glands.
Nowroozi
N
N
Departments of Orthodontics and Basic Sciences, University of Southern California School of Dentistry, Los Angeles, California, USA.
Kim
S
S
Segawa
A
A
Warita
H
H
Rice
D H
DH
Denny
P C
PC
Zernik
J H
JH
D008949:Adenoma, Pleomorphic / Q000737:chemistry; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D005677:G(M1) Ganglioside / Q000032:analysis*; D006801:Humans; D051379:Mice; D010306:Parotid Gland / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism*; D010307:Parotid Neoplasms / Q000737:chemistry; D001616:beta-Galactosidase / Q000032:analysis*
D005677:G(M1) Ganglioside; D001616:beta-Galactosidase