title: Secretory meningioma of the brain. Report of two cases.
abstract: Two cases of cerebral secretory meningioma, occurring in 57 and 33-year-old females are reported. The tumors were located in the tentorial and frontotemporal region, respectively. The general histologic appearance of the tumors was of meningothelial meningioma (case 1) and meningioma with microcystic and angiomatous features (case 2). The most striking histological finding in both tumors were numerous pseudopsammoma bodies, localized chiefly around blood vessels. The inclusions were slightly eosinophilic, stained strongly with PAS method and were differing in size from 3 to 30 microns. Tumor cells containing or surrounding pseudopsammomas were immunopositive for cytokeratin and epithelial membrane antigen. In the first case, individual pseudopsammomas were strongly positive for carcinoembryonic antigen. Some diagnostic aspects of this antigen and problems regarding differential diagnosis in secretory meningioma are briefly discussed.
authors.affiliation: Clinical Department of Neurosurgery and Neurotraumatology, Bytom.
authors.forename: J
authors.initials: J
authors.lastname: Słowiński
authors.forename: J
authors.initials: J
authors.lastname: Kałuza
authors.forename: D
authors.initials: D
authors.lastname: Sabat
authors.forename: R
authors.initials: R
authors.lastname: Mrówka
authors.forename: D
authors.initials: D
authors.lastname: Lange
authors.forename: D
authors.initials: D
authors.lastname: Adamek
authors.forename: M
authors.initials: M
authors.lastname: Betlej
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008577:Meningeal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D013702:Temporal Lobe / Q000473:pathology* / Q000601:surgery