Memory consolidation in Drosophila operant visual learning.
A new conditioning procedure, developed for the operant learning paradigm at the flight simulator, leads to stronger learning scores in wild-type flies. This procedure produces mean learning indices up to LI = 0.52. The heat-avoidance behavior acquired during training is very difficult to extinguish during extinction. Memory decays quickly during the first 3 hr after training and still is measurable 48 hr later. Disruption experiments demonstrate that memory can be disrupted by cold anesthesia within the first approximately 20 min after training, whereas KCl- and CXM-feeding regimens abolish memory soon after training and 3 hr later, respectively. These results initially suggest at least three distinct memory phases involved in memory consolidation in Drosophila after operant conditioning.
Xia
S
S
Laboratory of Visual Information Processing, Institute of Biophysics, Beijing, People's Republic of China.
Liu
L
L
Feng
C
C
Guo
A
A
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D003513:Cycloheximide / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000502:physiology*; D005108:Extinction, Psychological; D006358:Hot Temperature; D008568:Memory / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*
D011189:Potassium Chloride; D003513:Cycloheximide