Effect of Cryptotympana atrata extract on compound 48/80-induced anaphylactic reactions.
We studied the effect of the aqueous extract of Cryptotympana atrata Fabricius on anaphylactic reactions. Cryptotympana atrata completely inhibited compound 48/80-induced systemic anaphylactic shock at doses of 0.5 and 1.0 g/kg. When Cryptotympana atrata was given as pretreatment at concentrations ranging from 0.025 to 1.0 g/kg, the plasma histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. Cryptotympana atrata also inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. In addition, when Cryptotympana atrata was added, the level of cAMP in RPMC transiently and significantly increased about 14-fold compared with that of control cells. Our studies provide evidence that Cryptotympana atrata may be beneficial in the treatment of nonspecific anaphylactic reactions.
Shin
T Y
TY
College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea.
Park
J H
JH
Kim
H M
HM
D000707:Anaphylaxis / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006632:Histamine / Q000097:blood*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D015996:Survival Rate; D013997:Time Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity*
D010936:Plant Extracts; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D000242:Cyclic AMP