Ki-67 is strongly prognostic in synovial sarcoma: analysis based on 86 patients from the Scandinavian Sarcoma group register.
In a study based on formalin-fixed paraffin-embedded material from 86 patients with primary synovial sarcoma located in the extremities or on the trunk wall, the prognostic importance of MIB-1 index, p53-expession and tumour size was analysed. Multivariate analysis identified two metastatic risk factors: increasing tumour size and MIB-1 > 9%. The 5-year metastasis-free survival-rate for patients with tumour size < or = 5 cm + MIB-1 < 10% was 0.83 (95% confidence interval (CI) 0.64-0.92) compared to 0.31 (95% CI 0.11-0.53) in cases with tumour size > 5 cm + MIB-1 > or = 10%. Our study shows that metastatic disease in synovial sarcoma is closely related to MIB-1 index. Using our model based on tumour size and MIB-1 index, cases with good and poor prognosis can easily be discriminated. Therefore our model can be used to identify patients who should be considered for adjuvant chemotherapy.
Skytting
B T
BT
Department of Orthopedics, Stockholm Soder Hospital, Sweden.
Bauer
H C
HC
Perfekt
R
R
Nilsson
G
G
Larsson
O
O
D034961:Antigens, Nuclear; D015415:Biomarkers / Q000032:analysis; D002467:Cell Nucleus / Q000473:pathology; D016001:Confidence Intervals; D018572:Disease-Free Survival; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D008940:Mitotic Index; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009687:Nuclear Proteins / Q000032:analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000401:mortality* / Q000473:pathology*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D034961:Antigens, Nuclear; D015415:Biomarkers; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53