Muscle necrosis in rats induced by 2-methoxy-p-phenylenediamine.
p-Phenylenediamine, together with several of its amino and alkyl derivatives, are known to be myotoxic in animals and man. In the present study, it was found that 2-methoxy-p-phenylenediamine, a component of oxidative hair dyes, similarly causes necrosis of skeletal muscle (gastrocnemius, diaphragm and tongue) in rats. The myotoxicity of 2-methoxy-p-phenylenediamine was much greater than that of p-phenylenediamine itself. This observation is consistent with the relative efficacy of these substances in disrupting mitochondrial metabolism, an effect which is believed to be responsible for the selective toxicity of p-phenylenediamine derivatives to muscle.
Munday
R
R
AgResearch, Ruakura Agricultural Research Centre, Hamilton, New Zealand.
Manns
E
E
D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D016877:Oxidants / Q000633:toxicity*; D010655:Phenylenediamines / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests
D000840:Anisoles; D016877:Oxidants; D010655:Phenylenediamines; C120924:1,4-diamino-2-methoxybenzene