Comparison of necrotic characteristics and benefits between 50% acetic acid and pure ethanol in local hepatic injection: a study in rats.
This study compares the characteristics of acetic acid and pure ethanol in local hepatic injection and identifies the possible benefits from acetic acid by an animal model. We injected 0.03 ml of pure ethanol and 0.01 ml of 50% acetic acid separately into different sites of the same liver. The shape and diameter of the lesions were recorded at 0 min, 5 min and 15 min, and 5 lesions were also reviewed one day later. The lesions induced by pure ethanol were irregular, whereas those induced by 50% acetic acid were round or oval. The diameter of lesions induced by 50% acetic acid was 2.62 +/- 0.58 mm initially and increased to 4.50 +/- 0.84 mm and 5.25 +/- 0.75 mm at 5 min and 15 min, (5 min compared with 0 min, p < 0.0001; 15 min compared with 5 min, p < 0.001) respectively. The diameters of lesions induced by pure ethanol did not increase. The diffusion diameter at 5 min and 15 min were 1.88 mm and 2.63 mm respectively. Furthermore, viable liver cells were occasionally found in two lesions induced by pure ethanol. Acetic acid had a more homogeneous distribution and better infiltrating ability than pure ethanol and may be superior to pure ethanol in local injection therapy of HCC. But more clinical trials in the treatment HCC should be carried out.
Hou
C
C
Department of Occupational Medicine, Kaohsiung Medical College Hospital, Taiwan, Republic of China.
Chen
S C
SC
Chang
W Y
WY
Chen
C H
CH
D019342:Acetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol; D019342:Acetic Acid