title: Effects of haloperidol or SCH-23390 on ethanol-induced conditioned taste aversion.
abstract: Dopaminergic systems are thought to play an important role in the motivational effects of ethanol. The present experiments examined the effects of haloperidol (a D2 antagonist) and SCH-23390 (a D1 antagonist) on the acquisition of ethanol-induced conditioned taste aversion. In four separate experiments, adult male Swiss-Webster mice were acclimated to a 2-h/day water restriction regimen. Subsequently they received four conditioning trials consisting of 1-h access to either 0.2 M NaCl (experiments 1-3) or 0.15 % w/v saccharin (experiment 4). After flavor access on trials 1-3, subjects received either haloperidol (0.1, 0.15, or 0.3 mg/kg), SCH-23390 (0.05 mg/kg), or saline followed 30 min later by 0, 2, or 4 g/kg ethanol. Ethanol-flavor pairings reduced subsequent flavor intakes, indicating the development of conditioned taste aversion. Neither haloperidol of SCH-23390 reduced flavor intakes in the absence of ethanol. However, both haloperidol and SCH-23390 reduced ethanol-conditioned aversion depending on ethanol dose and conditioned flavor. These results are consistent with the notion that dopaminergic processes are important for the development of ethanol-induced conditioned taste aversion, and the notion that dopaminergic receptor systems influence both positive and negative motivational effects of ethanol.
authors.affiliation: Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health Sciences University, 97201-3098, USA. risinger@ohsu.edu
authors.forename: F O
authors.initials: FO
authors.lastname: Risinger
authors.forename: M M
authors.initials: MM
authors.lastname: Brown
authors.forename: R A
authors.initials: RA
authors.lastname: Oakes
authors.forename: J A
authors.initials: JA
authors.lastname: Love
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000037:antagonists & inhibitors*; D003213:Conditioning, Psychological / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D000431:Ethanol / Q000008:administration & dosage*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors; D012965:Sodium Chloride / Q000008:administration & dosage; D013649:Taste / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D002492:Central Nervous System Depressants; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D000431:Ethanol; D012965:Sodium Chloride; D006220:Haloperidol