Primary hepatic diffuse large B-cell lymphoma in a patient with chronic hepatitis C.
Epidemiological and experimental data suggest that the hepatitis C virus infection might be associated with the development of distinct types of non-Hodgkin's lymphomas. Here, we report a case of a patient with chronic hepatitis C and type II mixed cryoglobulinemia, who developed a primary hepatic non-Hodgkin's B-cell lymphoma. A diffuse, large B-cell lymphoma was diagnosed based on morphological, immunophenotypical and molecular genetic findings. Hepatitis C virus replication, as evaluated by strand-specific reverse transcriptase-polymerase chain reaction, was detected in the nonneoplastic liver, but not in the lymphomatous tissue. High grade non-Hodgkin's lymphomas, although rare complications, have to be considered as part of the spectrum of hepatitis C virus-related hepatic lesions.
Rubbia-Brandt
L
L
Division of Clinical Pathology, University Hospital, Geneva, Switzerland. rubbia@dim.hcuge.ch
Bründler
M A
MA
Kerl
K
K
Negro
F
F
Nador
R G
RG
Scherrer
A
A
Kurt
A M
AM
Mentha
G
G
Borisch
B
B
D003449:Cryoglobulinemia / Q000209:etiology; D016174:Hepacivirus / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011859:Radiography