Nematode ageing: Putting metabolic theories to the test.
The increased life span caused by certain mutations in the nematode Caenorhabditis elegans has been interpreted in terms of two metabolic theories of ageing: the oxidative damage theory and the rate of living theory. New findings support the former, but not the latter interpretation.
Gems
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Department of Biology, University College London, 4 Stephenson Way, London, NW1 2HE, UK. d.gems@galton.ucl.ac.uk
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins; D002467:Cell Nucleus / Q000378:metabolism; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D008136:Longevity; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism; D009154:Mutation; D010101:Oxygen Consumption / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin / Q000235:genetics
C104339:CLK-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D019869:Phosphatidylinositol 3-Kinases; C100662:AGE-1 protein, C elegans; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin