Immune deficiency, immune silencing, and clonal exhaustion of T cell responses during viral infections.
Analyses of the complex regulatory networks leading to T cell survival, death, and immune deficiency have been aided in the past year by the dramatic development of new technologies to identify T cells and assess T cell function. These new techniques have shown that functional inactivation and apoptotic elimination of both virus-specific and non-virus-specific T cell populations mold T cell responses to viral infections.
Welsh
R M
RM
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. raymond.welsh@ummed.edu
McNally
J M
JM
D000818:Animals; D017209:Apoptosis; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*