Interactions of HIV-1 with antigen-presenting cells.
There is currently much interest in the numerical and functional loss of antigen-presenting cells (APC) in HIV-1 disease and the contribution that this may make to HIV-1 pathology. The HIV-1 virus can interfere with the normal function of APC in a number of ways involving inappropriate signalling. These include changes in cytokine balance, cell-surface molecule expression and intracellular signalling pathways. This review examines how HIV-1 is able to disregulate APC function and discusses possible outcomes for the function of the immune system.
Hewson
T
T
Department of Pathology, University of Edinburgh Medical School, Edinburgh, United Kingdom. t.j.hewson@ed.ac.uk
Lone
N
N
Moore
M
M
Howie
S
S
D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000821:virology; D017209:Apoptosis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D016207:Cytokines / Q000096:biosynthesis; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000209:etiology / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008561:Membrane Fusion; D011110:Polymorphism, Genetic; D015728:Receptors, HIV / Q000235:genetics; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000276:immunology; D014779:Virus Replication
D016207:Cytokines; D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D006680:HLA Antigens; D015728:Receptors, HIV