Linkage analysis of the hph-1 mutation and the GTP cyclohydrolase I structural gene.
Our research establishes genetic linkage between the hph-1 mutation and the GTP-CH I structural gene. Our results indicate that these two loci are within an 8 cM region with 95% confidence. This finding lends additional support for the use of the hph-1 mouse mutant as a bona fide model system for the human disorder GTP-CH I to further our understanding of the molecular mechanisms involved in the disease pathology of GTP-CH I deficiency.
Montañez
C S
CS
Department of Biological Sciences, Wichita State University, 1845 Fairmount, Wichita, Kansas 67260-0026, USA.
McDonald
J D
JD
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D006136:GTP Cyclohydrolase / Q000172:deficiency / Q000235:genetics*; D005796:Genes / Q000235:genetics; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains; D009154:Mutation
D006136:GTP Cyclohydrolase