title: In vitro activities of BMS-207147 against over 600 contemporary clinical bloodstream isolates of Candida species from the SENTRY Antimicrobial Surveillance Program in North America and Latin America.
abstract: We compared the in vitro activity of BMS-207147, an investigational triazole, with those of itraconazole and fluconazole against 613 clinical bloodstream isolates of Candida spp. collected from SENTRY participating hospitals during 1997 and 1998. Overall, BMS-207147 was the most active azole against all Candida spp. While both BMS-207147 and itraconazole displayed a stepwise decrease in activity against isolates for which the fluconazole MICs were elevated, BMS-207147 had two- to fourfold greater activity than itraconazole both against Candida spp. that were dose-dependently fluconazole susceptible and against those that were fluconazole resistant.
authors.affiliation: Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
authors.forename: S A
authors.initials: SA
authors.lastname: Messer
authors.forename: A
authors.initials: A
authors.lastname: Houston
authors.forename: R J
authors.initials: RJ
authors.lastname: Hollis
authors.forename: G V
authors.initials: GV
authors.lastname: Doern
authors.forename: R N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification*; D004305:Dose-Response Relationship, Drug; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D007843:Latin America; D008826:Microbial Sensitivity Tests; D009656:North America; D011159:Population Surveillance; D013844:Thiazoles / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D013844:Thiazoles; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; C104066:ER 30346