Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans.
To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.
Sofuoglu
M
M
Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA. sufuo001@tc.umn.edu
Dudish-Poulsen
S
S
Nelson
D
D
Pentel
P R
PR
Hatsukami
D K
DK
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology; D016578:Crack Cocaine; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology* / Q000523:psychology; D011374:Progesterone / Q000097:blood; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
D016578:Crack Cocaine; D018765:Dopamine Uptake Inhibitors; D011374:Progesterone; D004958:Estradiol; D003042:Cocaine