Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists.
We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors.
Bergmeier
S C
SC
Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus 43210-1291, USA.
Lapinsky
D J
DJ
Free
R B
RB
McKay
D B
DB
D000157:Aconitine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000187:drug effects / Q000378:metabolism; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000470:Alkaloids; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; C054634:methyllycaconitine; D000157:Aconitine