No significant effects of sodium aurothiomalate on haem metabolism and mixed function oxygenase activity in patients with rheumatoid arthritis.
OBJECTIVE
Animal studies suggest that gold compounds impair haem synthesis and increase haem degradation and, as a result, reduce activity of the hepatic haemoproteins cytochromes P-450. The aim of this study was to investigate whether intramuscular gold exerts similar effects in patients with rheumatoid arthritis (RA).


METHODS
Urinary porphyrin and precursor excretion, erythrocyte protoporphyrin, and antipyrine clearance, were measured in 6 patients with RA before and 10 weeks after commencement of intramuscular gold.


RESULTS
Parameters of haem metabolism were unaffected by gold. While antipyrine clearance was not statistically changed after gold treatment, in 3 of the patients there was an average decrease in antipyrine clearance of 23%.


CONCLUSIONS
Further studies examining RA patients at different time points are required to investigate further the possibility of reduced hepatic drug metabolising activity during prolonged treatment with gold.
Herrick
A L
AL
University of Manchester Rheumatic Diseases Centre, Hope Hospital, Manchester, UK.
Hodgkiss
R
R
Reed
P
P
Weinkove
C
C
Jayson
M I
MI
Houston
B
B
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D018501:Antirheumatic Agents / Q000008:administration & dosage*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage*; D006418:Heme / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011166:Porphyrins / Q000652:urine; D011524:Protoporphyrins / Q000032:analysis
D018501:Antirheumatic Agents; D011166:Porphyrins; D011524:Protoporphyrins; D006052:Gold Sodium Thiomalate; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D000983:Antipyrine