title: Microcystic meningioma arising in a mixed germ cell tumor of the testis: a case report.
abstract: We report a case of a microcystic variant of meningioma arising in a mixed germ cell tumor of the testis composed predominantly of mature and immature teratoma with elements of seminoma and embryonal carcinoma. We believe this is the first such case of a meningioma arising in a teratoma within a gonadal or extragonadal site. The meningiomatous component showed positive immunohistochemical staining for epithelial membrane antigen and a lack of staining for cytokeratin, factor VIII, CD31, and alpha-fetoprotein. Recognition of a non-germ cell tumor arising in the setting of a teratoma in the testis may be prognostically important depending on the nature of the non-germ cell component and whether it has spread beyond the testis.
authors.affiliation: The Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Allen
authors.forename: P C
authors.initials: PC
authors.lastname: Burger
authors.forename: J I
authors.initials: JI
authors.lastname: Epstein
mesh_terms: D000328:Adult; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D008579:Meningioma / Q000473:pathology / Q000503:physiopathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000503:physiopathology; D013736:Testicular Neoplasms / Q000473:pathology / Q000503:physiopathology