title: Dynamic outflow obstruction due to the transient extensive left ventricular wall motion abnormalities caused by acute myocarditis in a patient with hypertrophic cardiomyopathy: reduction in ventricular afterload by disopyramide.
abstract: A 65-year-old woman was admitted to the coronary care unit because of acute pulmonary edema. Immediate 2-dimensional and Doppler echocardiograms revealed extensive left ventricular wall motion abnormalities and left ventricular hypertrophy with extreme outflow obstruction. Although an ECG showed ST-segment elevation in the anterolateral leads, a coronary arteriogram revealed normal epicardial arteries. Heart failure was relieved after diminishing the dynamic outflow obstruction with disopyramide administration. An endomyocardial biopsy from the right ventricle on the 8th hospital day showed borderline myocarditis. Wall motion abnormalities gradually normalized within 2 weeks. It is speculated that her pulmonary edema would not have been relieved so readily without the immediate reduction in ventricular afterload by disopyramide. These clinical changes over time were observed with serial echo-Doppler examinations.
authors.affiliation: Critical Care Medical Center, Department of Medicine, Wakayama Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Tomobuchi
authors.forename: T
authors.initials: T
authors.lastname: Hano
authors.forename: I
authors.initials: I
authors.lastname: Nishio
mesh_terms: D000208:Acute Disease; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D017023:Coronary Angiography; D004206:Disopyramide / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D009205:Myocarditis / Q000150:complications*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000209:etiology*; D014694:Ventricular Outflow Obstruction / Q000188:drug therapy / Q000209:etiology*
chemical_list: D004206:Disopyramide