title: Spectral simulations incorporating gradient coherence selection.
abstract: Computer-aided methods can considerably simplify the use of the product operator formalism for theoretical analysis of NMR phenomena, which otherwise becomes unwieldy for anything but simple spin systems and pulse sequences. In this report, two previously available programming approaches using symbolic algebra (J. Shriver, Concepts Magn. Reson. 4, 1-33, 1992) and numerical simulation using object-oriented programming (S. A. Smith, T. O. Levante, B. H. Meier, and R. R. Ernst, J. Magn. Reson. A 106, 75-105, 1994) have been extended to include the use of gradient operators for simulation of spatially localized NMR spectroscopy and gradient coherence selection. These methods are demonstrated using an analysis of the response of an AX(3) spin system to the STEAM pulse sequence and verified with experimental measurements on lactate.
authors.affiliation: MR Unit (114M), University of California at San Francisco, DVA Medical Center, 4150 Clement Street, San Francisco, California 94121, USA.
authors.forename: K
authors.initials: K
authors.lastname: Young
authors.forename: G B
authors.initials: GB
authors.lastname: Matson
authors.forename: V
authors.initials: V
authors.lastname: Govindaraju
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
mesh_terms: D003198:Computer Simulation; D019992:Databases as Topic; D005583:Fourier Analysis; D019344:Lactic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015233:Models, Statistical; D012984:Software
chemical_list: D019344:Lactic Acid