Genetic engineering of doxorubicin production in Streptomyces peucetius: a review.
The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.
Hutchinson
C R
CR
School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA.
Colombo
A L
AL
D000970:Antineoplastic Agents / Q000378:metabolism*; D003630:Daunorubicin / Q000096:biosynthesis / Q000378:metabolism; D004317:Doxorubicin / Q000096:biosynthesis*; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D013302:Streptomyces / Q000378:metabolism*
D000970:Antineoplastic Agents; D004317:Doxorubicin; D003630:Daunorubicin