title: Is there a correlation between degree of splenomegaly, symptoms and hypersplenism? A study of 218 patients with Gaucher disease.
abstract: Despite the prevalence of splenomegaly as a sign in many disorders, there have been no studies that correlate the degree of organomegaly with the symptoms generally ascribed to splenic enlargement. The degree of splenomegaly was compared with five overt symptoms of mechanical displacement, i.e. chronic abdominal pain, abdominal discomfort, early satiety, pain while lying on the side, or attacks of acute (colicky) left upper quadrant pains. We have also employed splenomegaly as seen in Gaucher disease as a paradigm to determine whether there is a correlation between the degree of splenomegaly and the parameters of hypersplenism. Although there was a statistically significant correlation between degree of splenomegaly and blood counts, this proved to be clinically negligible. Surprisingly, there was also no correlation between degree of splenomegaly and any of symptoms investigated.
authors.affiliation: Gaucher Clinic, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Gielchinsky
authors.forename: D
authors.initials: D
authors.lastname: Elstein
authors.forename: I
authors.initials: I
authors.lastname: Hadas-Halpern
authors.forename: A
authors.initials: A
authors.lastname: Lahad
authors.forename: A
authors.initials: A
authors.lastname: Abrahamov
authors.forename: A
authors.initials: A
authors.lastname: Zimran
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005776:Gaucher Disease / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000209:etiology* / Q000473:pathology; D007223:Infant; D007958:Leukocyte Count; D010976:Platelet Count; D013163:Splenomegaly / Q000209:etiology*