[The hemolytic-uremic syndrome].
The microangiopathic thrombotic syndromes--thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS)--are characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, fever and central nervous system abnormalities. Today they are considered as two extremes of a continuous spectrum named TTP--HUS. The syndrome is an uncommon disease with a high mortality rate, despite treatment. The authors describe a case of hemolytic uremic syndrome in a young adult patient. Initially the clinical course and the first biopsy suggested a favourable prognosis, but the early recurrence with severe hypertension was followed by a fatal outcome 6 months later. Concerning this clinical case, the authors present a review of the most recent aspects of the pathogenesis and treatment of this syndrome.
Rodrigues
P A
PA
Serviço de Medicina, Hospital Curry Cabral, Lisboa.
Machado
J
J
Cardoso
O
O
Cruz
J
J
Carvalho
F
F
da Costa
M
M
Proença
R
R
D000293:Adolescent; D001706:Biopsy; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D013997:Time Factors