title: Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists.
abstract: Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Ryder
authors.forename: L Y
authors.initials: LY
authors.lastname: Hu
authors.forename: M F
authors.initials: MF
authors.lastname: Rafferty
authors.forename: S M
authors.initials: SM
authors.lastname: Lotarski
authors.forename: D M
authors.initials: DM
authors.lastname: Rock
authors.forename: S J
authors.initials: SJ
authors.lastname: Stoehr
authors.forename: C P
authors.initials: CP
authors.lastname: Taylor
authors.forename: M L
authors.initials: ML
authors.lastname: Weber
authors.forename: G P
authors.initials: GP
authors.lastname: Miljanich
authors.forename: E
authors.initials: E
authors.lastname: Millerman
authors.forename: B G
authors.initials: BG
authors.lastname: Szoke
mesh_terms: D000161:Acoustic Stimulation; D000595:Amino Acid Sequence; D000814:Aniline Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology; D013329:Structure-Activity Relationship
chemical_list: D000814:Aniline Compounds; D002121:Calcium Channel Blockers; C121658:PD 181283; D007930:Leucine