Variation in the diffusion and release of ribonuclease through and from esterified hyaluronic acid membranes: effect of changes in matrix characteristics.
50 h) were detected for the transport and release of a model protein (ribonuclease A) compared with that for the translucent region which showed no lag time. The results highlight the importance of carefully controlling matrix formation to ensure reproducible transport and release characteristics from polymer matrices.
Simon
L D
LD
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66045, USA.
Stella
V J
VJ
Charman
W N
WN
Charman
S A
SA
D004058:Diffusion; D016503:Drug Delivery Systems; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D012259:Ribonuclease, Pancreatic / Q000008:administration & dosage / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D006820:Hyaluronic Acid; D012259:Ribonuclease, Pancreatic