Pharmacological effects of Agapanthus africanus on the isolated rat uterus.
The Agapanthus africanus plant is used by South African traditional healers as a phytomedicine in herbal remedies to treat pregnancy-related ailments and to augment labour. It has already been shown that an aqueous extract of A. africanus causes smooth muscle contractions in the isolated uterus and ileum preparations. In the present study, the effects of an aqueous extract of A. africanus leaves was examined on receptor systems involved in contraction of the uterine smooth muscle in order to determine the mechanism of its pharmacological effect relevant to its ethnic use to augment labour. The extract was tested on the isolated rat uterus preparation. The aqueous extract of A. africanus leaves was found to exhibit agonist activity on uterine muscarinic receptors and to promote the synthesis of prostaglandins in the oestrogenized rat uterus. Some pharmacological justification for the ethnic use of A. africanus as a herbal oxytocic in prolonged labour has been provided.
Veale
D J
DJ
Department of Experimental and Clinical Pharmacology, Medical School, University of the Witwatersrand, Johannesburg, South Africa. theveales@icon.co.za
Havlik
I
I
Oliver
D W
DW
Dekker
T G
TG
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D008519:Medicine, Traditional; D018721:Muscarinic Agonists / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D013019:South Africa; D014599:Uterus / Q000187:drug effects*
D018721:Muscarinic Agonists; D010936:Plant Extracts; D011453:Prostaglandins; D010121:Oxytocin; D004054:Diethylstilbestrol; D001285:Atropine; D000109:Acetylcholine; D007213:Indomethacin