Gene silencing: RNA makes RNA makes no protein.
A mutation that disrupts post-transcriptional gene silencing in Neurospora crassa has been found to affect the homologue of a plant-encoded RNA-dependent RNA polymerase. This enzyme may produce a specificity determinant of gene silencing and mediate an epigenetic conversion at the RNA level.
Baulcombe
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DC
The Sainsbury Laboratory, John Innes Centre, Norwich, NR4 7UH, UK. david.baulcombe@bbsrc.ac.uk
D005656:Fungal Proteins / Q000235:genetics; D020868:Gene Silencing; D009154:Mutation; D009492:Neurospora crassa / Q000737:chemistry / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics / Q000502:physiology; D016372:RNA, Antisense / Q000235:genetics / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics* / Q000378:metabolism
D005656:Fungal Proteins; D016372:RNA, Antisense; C119303:QDE1 protein, Neurospora crassa; D012324:RNA-Dependent RNA Polymerase