title: Thermodynamic ionization constants of antihypertensive drugs.
abstract: The thermodynamic ionization constants (pKa) of indapamide, clonidine and methyldopa have been determined at 25 degrees C and 35 degrees C by pH titration technique. The pKa varies linearly with mole fraction of dioxane. The thermodynamic parameters have been calculated.
authors.affiliation: Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India.
authors.forename: Y K
authors.initials: YK
authors.lastname: Agrawal
authors.forename: S K
authors.initials: SK
authors.lastname: Menon
authors.forename: F
authors.initials: F
authors.lastname: Majumudar
authors.forename: V K
authors.initials: VK
authors.lastname: Jain
mesh_terms: D000465:Algorithms; D000959:Antihypertensive Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013816:Thermodynamics
chemical_list: D000959:Antihypertensive Agents