title: Vertebral osteomyelitis in northern Spain. Report of 62 cases.
abstract: OBJECTIVE
  The records of 62 patients with clinical and radiographic evidence of vertebral osteomyelitis and positive bacteriological diagnosis, seen between 1979 and 1996, were reviewed in order to gather data on the epidemiology and the clinical pattern displayed by patients with this condition in northern Spain.
  
  
  RESULTS
  Staphylococcus aureus (15 cases), Mycobacterium tuberculosis (15 cases) and Brucella melitensis (13 cases) were the microorganisms most frequently found in our patient series. After improvement of the sanitary and hygienic control of food products, the role of Brucella melitensis is decreasing as a causative agent (only 3 cases in the last 6 years). Staphylococcus epidermidis, present in 4 cases (6.6%), should be suspected in elderly patients with previous intravenous cannulations (3 of 4 cases). The most frequent risk factors were alcoholism (7 cases), chronic hepatic disease (7 cases), diabetes (6 cases) and previous surgery (6 cases). Delay in diagnosis was high (the mean number of days between the onset of symptoms and diagnosis was 125). The lumbar region was the most commonly affected site. Neurologic involvement was present in 10 patients on admission (16%). ESR was > 50 mm/hr in a high number of cases. Blood cultures were found to be the most valuable routine test. Plain x-rays were normal in 10 patients (16%); in 6 of them Staphylococcus aureus was the responsible organism. Other imaging modalities showed a high sensitivity. Surgical drainage was necessary in 12 individuals (in 7 due to Mycobacterium tuberculosis). Outcome was good in the majority of cases: only 2 patients with associated endocarditis died. Neurologic sequelae were present in another 3 patients.
  
  
  CONCLUSIONS
  Vertebral osteomyelitis can be caused by a variety of pathogens. Therefore, bacteriological studies are necessary to establish the etiologic diagnosis and determine the specific antimicrobial treatment required.
authors.affiliation: Rheumatology Unit, Hospital N.S. de Aránzazu, San Sebastián, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Belzunegui
authors.forename: N
authors.initials: N
authors.lastname: Del Val
authors.forename: J J
authors.initials: JJ
authors.lastname: Intxausti
authors.forename: J R
authors.initials: JR
authors.lastname: De Dios
authors.forename: R
authors.initials: R
authors.lastname: Queiro
authors.forename: C
authors.initials: C
authors.lastname: González
authors.forename: V
authors.initials: V
authors.lastname: Rodríguez-Valverde
authors.forename: M
authors.initials: M
authors.lastname: Figueroa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000995:Antitubercular Agents / Q000008:administration & dosage; D017347:Brucella melitensis; D002006:Brucellosis / Q000188:drug therapy / Q000453:epidemiology*; D002574:Cervical Vertebrae; D003023:Cloxacillin / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D010406:Penicillins / Q000008:administration & dosage; D012307:Risk Factors; D012447:Sacrum; D013030:Spain / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology*; D013211:Staphylococcus aureus; D016896:Treatment Outcome; D014399:Tuberculosis, Spinal / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D010406:Penicillins; D004318:Doxycycline; D003023:Cloxacillin