title: Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides.
abstract: HIV-1 DNA integration is carried out by integrase, a viral protein which binds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations of mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which were designed to form an alternate strand triple helix with the U5 LTR end containing two adjacent purine tracts on opposite strands 5'-GGAAAATCTCT-3'/3'-CCTTTTAGAGA-5'.
authors.affiliation: CNRS-UMR 1772, Institut Gustave Roussy, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Brodin
authors.forename: M
authors.initials: M
authors.lastname: Gottikh
authors.forename: C
authors.initials: C
authors.lastname: Auclair
authors.forename: J F
authors.initials: JF
authors.lastname: Mouscadet
mesh_terms: D001483:Base Sequence; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000502:physiology*; D009841:Oligonucleotides / Q000494:pharmacology*; D016662:Virus Integration / Q000187:drug effects*
chemical_list: D009841:Oligonucleotides