[Premixing of 5% dextrose in Ringer's acetate solution with propofol reduces incidence and severity of pain on propofol injection].
The purpose of this study was to compare the effect of premixed 5% dextrose in Ringer's acetate solution and premixed lidocaine with propofpl on the reduction of pain during injection of propofol in adult patients. We conducted a prospective, randomized, double-blinded trial. Ninety-six patients were randomly allocated to one of three groups according to the agents added to 1% propofol 20 ml; Group C, normal saline 2 ml, Group L, 2% lidocaine 2 ml, and Group A, 5% dextrose in Ringer's acetate solution 2 ml. The pain on injection was rated as none, mild, moderate, or severe. Seventy percent of patients in the C group experienced pain, while 33% and 25% of patients experienced pain in the A group and the L group, respectively. Forty-two percent of patients in the C group complained moderate to severe pain but only one patient in both A group and L group. In conclusion, 5% dextrose in Ringer's acetate solution premixed with 200 mg propofol significantly reduces incidence and severity of pain associated with propofol injection and is easier to use than premixed lidocaine.
Nonaka
A
A
Department of Anesthesiology, Yamanashi Medical University.
Tamaki
F
F
Sugawara
T
T
Oguchi
T
T
Kashimoto
S
S
Kumazawa
T
T
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D004311:Double-Blind Method; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D007552:Isotonic Solutions; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D012996:Solutions
D007552:Isotonic Solutions; C028570:Ringer's acetate; D012996:Solutions; D008012:Lidocaine; D005947:Glucose; D015742:Propofol