title: Chloride and ethyl ester morpholine thiourea derivatives and their Ni(II) complexes. Crystal and molecular structures of the thiourea derivative L-leucine methyl ester and its complexes with Cu(II) and Pt(II). Growth of the pathogenic fungus Botrytis cinerea.
abstract: We have synthesized a series of ligands (1, 3, 4, 6 and 7) and some of their complexes with Ni(II), Cu(II) and Pt(II) (2, 5, 8 and 9). These compounds were studied and characterized by elemental analysis, IR and UV-Vis spectra, conductivity measurements in solution, FAB+/MS, 1H and 13C NMR, ESR, etc. Compound 7 crystallized in the orthorhombic space group P2(1)2(1)2(1), with Z = 4. Unit cell parameters were as follows: a = 21.307(2) A, alpha = 90 degrees, b = 12.498(1) A, beta = 90 degrees, c = 7.7232(4) A, gamma = 90 degrees. For seven of these compounds, the antifungal activity of a major pathogen responsible for important crop damage was studied. In general, inhibition by the ligands was higher than that of the complexes. When the thiourea was linked to some diethyl groups, the compounds showed higher antifungal activity than the morpholine groups. Compound 3 achieved total inhibition (100%).
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Rodríguez-Fernández
authors.forename: E
authors.initials: E
authors.lastname: García
authors.forename: M R
authors.initials: MR
authors.lastname: Hermosa
authors.forename: A
authors.initials: A
authors.lastname: Jiménez-Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Mar Sánchez
authors.forename: E
authors.initials: E
authors.lastname: Monte
authors.forename: J J
authors.initials: JJ
authors.lastname: Criado
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D020171:Botrytis / Q000254:growth & development*; D002712:Chlorides / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D006860:Hydrogen Bonding; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009025:Morpholines / Q000737:chemistry; D013057:Spectrum Analysis; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D002712:Chlorides; D004952:Esters; D008670:Metals; D009025:Morpholines; C037574:morpholine; D013890:Thiourea