title: Age-associated differences in immunoglobulin G1 (IgG1) and IgG2 subclass antibodies to pneumococcal polysaccharides following vaccination.
abstract: Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups.
authors.affiliation: Department of Internal Medicine and Center for Vaccine Development, Saint Louis University, St. Louis, Missouri, USA. lottenkr@slu.edu
authors.forename: K R
authors.initials: KR
authors.lastname: Lottenbach
authors.forename: C M
authors.initials: CM
authors.lastname: Mink
authors.forename: S J
authors.initials: SJ
authors.lastname: Barenkamp
authors.forename: E L
authors.initials: EL
authors.lastname: Anderson
authors.forename: S M
authors.initials: SM
authors.lastname: Homan
authors.forename: D C
authors.initials: DC
authors.lastname: Powers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007223:Infant; D008875:Middle Aged; D022242:Pneumococcal Vaccines; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines