title: Multifocal osteosarcoma as second tumor after childhood retinoblastoma.
abstract: We present a case of multifocal osteosarcoma (MFOS) arising 11.5 years after successful treatment of bilateral retinoblastoma. The clinical, imaging and pathological findings at onset, after therapy, and during follow-up are described. Fluorescent in situ hybridization did not reveal a deletion of the RB-1 retinoblastoma gene, although the presence of an inactivating mutation invisible to this method cannot be ruled out. The MFOS may have been a second multifocal tumor associated with the original retinoblastoma or a post-irradiation sarcoma with extensive metastases.
authors.affiliation: Department of Diagnostic Imaging, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Potepan
authors.forename: R
authors.initials: R
authors.lastname: Luksch
authors.forename: G
authors.initials: G
authors.lastname: Sozzi
authors.forename: A
authors.initials: A
authors.lastname: Testi
authors.forename: A
authors.initials: A
authors.lastname: Laffranchi
authors.forename: G M
authors.initials: GM
authors.lastname: Danesini
authors.forename: A
authors.initials: A
authors.lastname: Parafioriti
authors.forename: R
authors.initials: R
authors.lastname: Giardini
authors.forename: I
authors.initials: I
authors.lastname: Spagnoli
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000209:etiology; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D012516:Osteosarcoma / Q000175:diagnosis* / Q000209:etiology; D011859:Radiography; D011877:Radionuclide Imaging; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging*; D012175:Retinoblastoma / Q000532:radiotherapy*