Can hepatitis B core antibody positive livers be used safely for transplantation: hepatitis B virus detection in the liver of individuals who are hepatitis B core antibody positive.
A major impediment to the wider application of clinical liver transplantation is the paucity of acceptable organs. Most centers refuse organs that come from donors who are hepatitis B core antibody positive because of a fear of transmission of hepatitis B virus (HBV) infection to the recipient. The risk related to the use of such donor organs has never been assessed in an ordered manner. The presence or absence of polymerase chain reaction detectable HBV-DNA in liver tissue of individuals undergoing liver biopsy for clinical reasons was assessed in 133 consecutive patients. A total of 8.2% of these livers resulted positive for HBV-DNA; interestingly the rate was higher among those who were hepatitis B surface antibody positive (12.5%) as compared to those without detectable hepatitis B surface antibody (5.7%). These data provide measures of putative risk for HBV infection in liver transplant recipients associated with the use of organs obtained from a hepatitis B core antibody positive donor.
Van Thiel
D H
DH
Department of Medicine, Loyola University at Chicago, Maywood, Illinois 60153, USA.
De Maria
N
N
Colantoni
A
A
Friedlander
L
L
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000635:transmission / Q000821:virology; D006510:Hepatitis B Antibodies / Q000378:metabolism*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000821:virology*; D016031:Liver Transplantation / Q000009:adverse effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012449:Safety; D014019:Tissue Donors
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens