title: Gabapentin does not affect antipyrine clearance.
abstract: The effect of gabapentin on antipyrine clearance was assessed in 12 healthy male volunteers, using a known enzyme inducer, phenytoin, as control. Subjects received gabapentin 400 mg or phenytoin 100 mg three times daily for 2 weeks. Antipyrine tests were performed before, during, and after treatment with gabapentin or phenytoin. In contrast to phenytoin, chronic administration of gabapentin did not affect antipyrine clearance. Gabapentin appears to have little potential for drug interactions.
authors.affiliation: Guy's Drug Research Unit, London, United Kingdom.
authors.forename: E
authors.initials: E
authors.lastname: Allen
authors.forename: L M
authors.initials: LM
authors.lastname: Tsanaclis
authors.forename: S J
authors.initials: SJ
authors.lastname: Wroe
authors.forename: P A
authors.initials: PA
authors.lastname: Reece
authors.forename: A J
authors.initials: AJ
authors.lastname: Sedman
mesh_terms: D000085:Acetates / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D000588:Amines; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics*; D003509:Cyclohexanecarboxylic Acids; D004311:Double-Blind Method; D004347:Drug Interactions; D000077206:Gabapentin; D006207:Half-Life; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D000077206:Gabapentin; D000983:Antipyrine