title: Fibre type specificity of haem oxygenase-1 induction in rat skeletal muscle.
abstract: The expression of the inducible haem oxygenase (HO-1) gene was examined in different skeletal muscles. Rats were treated with haemin and a time course of HO-1 mRNA expression was determined in soleus and extensor digitorum longus (EDL) muscles. Fibre type composition and tissue myoglobin content were also measured. We found that HO-1 mRNA expression markedly increased in soleus (type I fibres) muscle but was only slightly affected in EDL (type II fibres). HO-1 expression directly correlated with both percentage of red fibres and tissue myoglobin. These data demonstrate that HO-1 gene expression follows a fibre type-specific pattern which might indicate an important role for this protein in the maintenance of skeletal muscle function.
authors.affiliation: RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Vesely
authors.forename: R
authors.initials: R
authors.lastname: Sanders
authors.forename: C J
authors.initials: CJ
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Motterlini
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004790:Enzyme Induction / Q000235:genetics; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis* / Q000235:genetics; D051547:Heme Oxygenase-1; D006427:Hemin / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000201:enzymology; D018485:Muscle Fibers, Skeletal / Q000201:enzymology*; D018657:Muscle Fibers, Slow-Twitch / Q000201:enzymology; D018482:Muscle, Skeletal / Q000201:enzymology*; D009211:Myoglobin / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009211:Myoglobin; D012333:RNA, Messenger; D006427:Hemin; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; D008058:Dihydrolipoamide Dehydrogenase; D000251:Adenosine Triphosphatases