title: Immunopathogenesis of crescentic glomerulonephritis.
abstract: Crescentic glomerulonephritis provides an important therapeutic challenge because of its rapidly progressive course and poor outcome. Studies in animal models have elucidated some of the pivotal pathogenetic mechanisms, and human studies increasingly support the clinical relevance of these animal data. Accumulating evidence suggests that crescentic glomerulonephritis results from a complex cell-mediated nephritogenic immune response. Interruption of a number of immune and inflammatory mediators can improve the outcome of this disease.
authors.affiliation: Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. peter.tipping@med.monash.edu.au
authors.forename: P G
authors.initials: PG
authors.lastname: Tipping
authors.forename: A R
authors.initials: AR
authors.lastname: Kitching
authors.forename: M A
authors.initials: MA
authors.lastname: Cunningham
authors.forename: S R
authors.initials: SR
authors.lastname: Holdsworth
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002455:Cell Division; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D018836:Inflammation Mediators