title: Efficacy and safety of an intravenous induction therapy for treatment of disseminated Mycobacterium avium complex infection in AIDS patients: a pilot study.
abstract: Monotherapy with macrolides for the treatment of disseminated Mycobacterium avium complex (MAC) bacteraemia leads to drug resistance and relapse of bacteraemia. Gastrointestinal intolerance is a common reason for treatment withdrawal of multidrug regimens. We have assessed the efficacy and safety of initial parenteral therapy together with a macrolide, for disseminated MAC infection, defined as two positive blood cultures, in AIDS patients. Patients received a daily infusion of amikacin 15 mg/kg + ethambutol 20 mg/kg + ciprofloxacin 400 mg/day, for 1 month, together with a macrolide by oral route. Fifteen patients were included and 13 (86%) achieved negative culture before the end of parenteral therapy.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital de l'Archet I, Nice, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Roger
authors.forename: M
authors.initials: M
authors.lastname: Carles
authors.forename: I
authors.initials: I
authors.lastname: Agussol-Foin
authors.forename: L
authors.initials: L
authors.lastname: Pandiani
authors.forename: O
authors.initials: O
authors.lastname: Keïta-Perse
authors.forename: V
authors.initials: V
authors.lastname: Mondain
authors.forename: F
authors.initials: F
authors.lastname: De Salvador
authors.forename: P
authors.initials: P
authors.lastname: Dellamonica
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D018942:Macrolides; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy*; D010865:Pilot Projects
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides