Tamoxifen and hypertriglyceridemia.
A patient developed severe hypertriglyceridemia while on treatment with Tamoxifen after a mastectomy and with a statin for a lipid disorder. The mechanism of this side effect and the therapeutic effect of a fibrate are discussed.
Jonkers
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D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D000069059:Atorvastatin; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D002994:Clofibrate / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000188:drug therapy*; D015228:Hypertriglyceridemia / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use; D019821:Simvastatin / Q000627:therapeutic use; D013629:Tamoxifen / Q000009:adverse effects*; D016896:Treatment Outcome
D000924:Anticholesteremic Agents; D018931:Antineoplastic Agents, Hormonal; D006538:Heptanoic Acids; D011758:Pyrroles; D013629:Tamoxifen; D000069059:Atorvastatin; D019821:Simvastatin; D002994:Clofibrate