Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis.
A general association of human and primate lymphotropic herpesviruses (gamma-herpesviruses) with the development of lymphomas, as well as other tumors, especially in immunocompromised hosts, has been well documented. The lack of relevant small animal models for human gamma-herpesviruses has impeded progress in understanding the role of these viruses in the development of chronic disease. Recent research characterizing infection of inbred strains of mice with a murine gamma-herpesvirus, gamma-herpesvirus 68 (gammaHV68), is providing insights into viral and host factors involved in the establishment and control of chronic gamma-herpesvirus infection.
Speck
S H
SH
Department of Pathology, Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110-1093, USA. speck@pathology.wustl.edu
Virgin
H W
HW
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D018142:Gammaherpesvirinae / Q000235:genetics* / Q000502:physiology; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D051379:Mice; D017735:Virus Latency / Q000235:genetics