[Influence of PEEP on left ventricular diastolic function].
We investigated the influence of PEEP on left ventricular diastolic function using the pressure-volume loops by employing a micromanometer catheter and a conductance catheter placed in the left ventricle of the eight mongrel dogs. Time constant of diastolic interval was shortened under the condition of 15 cmH2O of PEEP compared with the control value (PEEP 0 cmH2O) and the diastolic stiffness constant was prolonged under 15 cmH2O of PEEP. It was considered that the shortened time constant of diastolic interval was due to the decrease of preload. The prolongation of diastolic stiffness constant was possibly due to compression of the heart by increased intrapleural pressure. We conclude that decreased compliance of left ventricle caused by PEEP might impair the left ventricular function.
Satoh
M
M
Department of Anesthesiology, School of Medicine, Keio University, Tokyo.
Takeda
J
J
Yamada
T
T
Koyama
K
K
Kondoh
M
M
Toyoda
Y
Y
D000818:Animals; D002302:Cardiac Output; D003971:Diastole / Q000502:physiology; D004285:Dogs; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D016277:Ventricular Function, Left