Induction of antitumor immunity using intercellular adhesion molecule 1 (ICAM-1) transfection in mouse glioma cells.
We investigated the role of intercellular adhesion molecule 1 (ICAM-1) expression in tumorigenicity of gliomas and the antitumor effects of glioma cells genetically engineered to express ICAM- 1. Mouse glioma cells transfected with ICAM-1 grew in T-cell deficient mice but not in syngeneic mice. Vaccination with ICAM-1-transfected tumor cells markedly inhibited the growth of subcutaneously inoculated gliomas but not gliomas located in the brain. In vivo antibody ablation study revealed that CD4+ T, CD8+ T and NK cells were all required to produce the antitumor effect of SR/ICAM- 1. In this study, we demonstrated the therapeutic potential of vaccination with ICAM-1-overexpressing tumor cells for the control of the tumor growth.
Kikuchi
T
T
The Institute of DNA Medicine, Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan. oncol-tk@po.iijnet.or.jp
Joki
T
T
Akasaki
Y
Y
Abe
T
T
Ohno
T
T
D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy*; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D005910:Glioma / Q000473:pathology / Q000628:therapy*; D007114:Immunization; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*; D016176:T-Lymphocyte Subsets; D014162:Transfection; D014407:Tumor Cells, Cultured
D019496:Cancer Vaccines; D018799:Intercellular Adhesion Molecule-1