Protection against cytotoxic effects of arsenic by dietary supplementation with crude extract of Emblica officinalis fruit.
Dietary administration of a crude aqueous extract of Emblica officinalis Gaertn. fruit reduced significantly the cytotoxic effects of sodium arsenite administered orally. The crude extract (685 mg/kg bw) was given daily by gavaging to age and sex matched laboratory bread Swiss albino mice for 7 and 14 days, followed by a single dose of sodium arsenite (2.5 mg/kg bw = 1/10 of LD(50)). The animals were killed after 24 h and chromosome preparations made following a schedule of colchicine-fixative-air drying-Giemsa. The endpoints screened were chromosomal aberrations and damaged cells. The crude extract reduced arsenic damage bringing the cells almost to the normal level.
Biswas
S
S
Vivekananda Institute of Medical Sciences, 99 Sarat Bose Road, Calcutta 700 026, India.
Talukder
G
G
Sharma
A
A
D000818:Animals; D001151:Arsenic; D020261:Arsenic Poisoning; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002869:Chromosome Aberrations; D019587:Dietary Supplements; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*
D010936:Plant Extracts; D020011:Protective Agents; D001151:Arsenic