Cure of beta-thalassaemia major by umbilical cord blood transplantation--a case report of Malaysia's first cord blood transplantation.
A 25-month-old boy with beta-thalassaemia major was presented with an opportunity for umbilical cord blood transplantation when his unborn sibling was diagnosed in utero to be a beta-thalassaemia carrier and also human leucocyte antigen compatible. A barely adequate amount of cord blood was collected at the birth of his sibling and infused into the patient after appropriate chemo-conditioning. Engraftment occurred without major complications. The subject is now alive and well 9 months post-transplant, thus marking our first success in umbilical cord blood transplantation.
Chan
L L
LL
Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia. chanll@medicine.med.um.edu.my
Lin
H P
HP
D015193:Chorionic Villi Sampling; D005260:Female; D005312:Fetal Blood; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D008296:Malaysia; D008297:Male; D014019:Tissue Donors; D017086:beta-Thalassemia / Q000628:therapy*