title: [Medical-surgical management of left heart valve prosthesis dysfunction due to obstruction. Eleven year's experience].
abstract: We report the surgical-medical experience in left side mechanic prosthesis cardiac valve dysfunction. From January 1986 to June 1997 we included 108 consecutive patients (pts), 24 were men and 84 women, mean age 45 years, they underwent 114 surgical procedures, 104 in mitral and 10 in aortic position.
  
  
  RESULTS
  The dysfunction was due to obstruction in fixed disc in 107 pts and intermitent in 7 pts. The pathological findings were thrombosis in 92 pts, pannus in 9 pts and both in 13 pts. The time interval between valve replacement and dysfunction was from 1 to 247 months, mean 53.8 +/- 56.7. Seventy five percent of patients received inadequate anticoagulant therapy, the mean INR was 2.06 +/- 0.79. In 76% of patients the functional class was III or IV NYHA. The diagnosis was made by clinical and echocardiographic findings in 96% of patients. The surgical procedures included valve replacement in 103, and toilette in 11 pts. The time of extracorporeal circulation in patients who died us survival patients were (159.9 +/- 108.95 vs 87.32 +/- 27.53 min) and aortic cross-clamp (64.8 +/- 20.69 vs 48.28 +/- 23.71 min) respectively (p < 0.001). The overall mortality was 12 pts (10.5%), all in functional class III or IV NYHA (p < 0.05), five patients died during surgical procedure. In conclusion the diagnosis must be established clinically as well as by echocardiography. The risk factors associated with mortality were pulmonary edema, shock, delayed surgery, surgical time prolonged and functional class III or IV NYHA.
authors.affiliation: Hospital de Cardiología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México, D. F.
authors.forename: J S
authors.initials: JS
authors.lastname: Valencia Sánchez
authors.forename: R
authors.initials: R
authors.lastname: Arriaga Nava
authors.forename: A
authors.initials: A
authors.lastname: Martínez Enríquez
authors.forename: J
authors.initials: J
authors.lastname: Navarro Robles
authors.forename: J A
authors.initials: JA
authors.lastname: Palomo Villada
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D011475:Prosthesis Failure; D012092:Replantation; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology / Q000601:surgery
chemical_list: D000925:Anticoagulants