title: Cerebral amyloid angiopathy in an aged great spotted woodpecker (Picoides major).
abstract: A male great spotted woodpecker (Picoides major), which was at least 16 years old, died due to general weakening. Cerebral vascular walls, including capillaries, were positively stained with Congo red with green-gold birefringence, and some of which showed a severe deposition of the Congophilic materials resulting in a corona-like fibrillar radiating structure. The Congophilic materials were positive for beta amyloid protein, but negative for prion protein. Only a few senile plaque-like structures were observed in the cortex by PAM stain and beta amyloid immunostain. The present case is the first observation of cerebral amyloid angiopathy in avian species and will indicate the presence of such age-related cerebral lesions also in birds.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. anakaya@mail.ecc.u-tokyo.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Katayama
authors.forename: A
authors.initials: A
authors.lastname: Ikawa
authors.forename: K
authors.initials: K
authors.lastname: Miyawaki
authors.forename: J
authors.initials: J
authors.lastname: Shinozuka
authors.forename: K
authors.initials: K
authors.lastname: Uetsuka
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Doi
mesh_terms: D000818:Animals; D001717:Birds / Q000502:physiology*; D001921:Brain / Q000473:pathology*; D002386:Cataract / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D058225:Plaque, Amyloid / Q000473:pathology