title: P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I.
abstract: A series of potent P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I is described.
authors.affiliation: Cephalon Inc., West Chester, PA 19380-4245, USA.
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: D
authors.initials: D
authors.lastname: Dunn
authors.forename: M
authors.initials: M
authors.lastname: Tao
authors.forename: G
authors.initials: G
authors.lastname: Wells
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Gu
authors.forename: R
authors.initials: R
authors.lastname: Bihovsky
authors.forename: M A
authors.initials: MA
authors.lastname: Ator
authors.forename: R
authors.initials: R
authors.lastname: Siman
authors.forename: J P
authors.initials: JP
authors.lastname: Mallamo
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D002154:Calpain / Q000037:antagonists & inhibitors*; D006801:Humans; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
chemical_list: D000577:Amides; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D002154:Calpain