title: Microbiologic spectrum and susceptibility of isolates: part I. Postoperative endophthalmitis. Endophthalmitis Research Group.
abstract: OBJECTIVE
  To present the microbial spectrum and susceptibilities of isolates in postoperative endophthalmitis.
  
  
  METHODS
  Isolates from 206 eyes of 206 patients who underwent vitrectomy for postoperative endophthalmitis were examined.
  
  
  RESULTS
  One-hundred twelve (54.4%) of 206 vitreous samples were culture positive and 14 (12.5%) of 112 culture-positive cases were polymicrobial, yielding a total of 126 isolates. Isolates included 59 (46.8%) gram-positive cocci, eight (6.3%) gram-positive bacilli, 33 (26.2%) gram-negative organisms, five (4.0%) Actino-mycetes-related organisms, and 21 (16.7%) fungi. Susceptibilities to amikacin, ceftazidime, chloramphenicol, cefazolin, ciprofloxacin, gentamicin, and vancomycin are reported.
  
  
  CONCLUSIONS
  This is the largest, single-center, prospective series on microbial susceptibilities in postoperative endophthalmitis. We report a high prevalence of gram-negative species and fungi, suggesting that empiric therapy should include coverage for gram-negative pathogens and for fungal pathogens in appropriate settings.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Cambridge, Massachusetts, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Kunimoto
authors.forename: T
authors.initials: T
authors.lastname: Das
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Jalali
authors.forename: A B
authors.initials: AB
authors.lastname: Majji
authors.forename: U
authors.initials: U
authors.lastname: Gopinathan
authors.forename: S
authors.initials: S
authors.lastname: Athmanathan
authors.forename: T N
authors.initials: TN
authors.lastname: Rao
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification*; D015169:Colony Count, Microbial; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology*; D005658:Fungi / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011183:Postoperative Complications / Q000188:drug therapy / Q000382:microbiology*; D011446:Prospective Studies; D014822:Vitreous Body / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents