title: Cogan's syndrome: unsuccessful outcome with early combination therapy.
abstract: Interstitial keratitis and vestibuloauditory symptoms (vertigo and hearing loss) are the typical signs of Cogan's syndrome, a rare inflammatory vascular disease. Signs of vasculitis in many organ systems may appear, among which neurologic problems are sometime predominant. The efficacy of glucocorticoids on the ocular and systemic symptoms is established, but their effect on hearing loss is unknown. We describe a case of Cogan's syndrome with neurological involvement in which early treatment with combination therapy (prednisolone and cyclosporin) failed to bring ear inflammation under control.
authors.affiliation: Cattedra di Reumatologia, Università degli Studi di Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Covelli
authors.forename: G
authors.initials: G
authors.lastname: Lapadula
authors.forename: V
authors.initials: V
authors.lastname: Pipitone
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007634:Keratitis / Q000188:drug therapy; D008775:Methylprednisolone / Q000008:administration & dosage*; D017211:Treatment Failure; D014657:Vasculitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D008775:Methylprednisolone