Cytogenetic localization of the growth and reproduction complex (Grc) in the rat and in the mouse and its position in relation to RT1.EC and other loci in the rat MHC.
The segment of rat chromosome 20 (RNO20p12) that contains the classical loci of the major histocompatibility complex (MHC; RT1.A-RT1.E) also contains genes affecting growth, reproduction and susceptibility to chemical carcinogens (the Grc) and multiple genes encoding class I MHC antigens (the EC region). The relative positions of the MHC, Grc, and EC region have not been demonstrated explicitly, although they have been postulated from genetic mapping studies. The present study was undertaken to map these regions cytogenetically by several different approaches using cosmids specific for the Rps 18, Hspa1 and Bat1 genes. The order was shown to be: centromere-Rps 18-Hspa1-Bat1-EC-Grc.
Helou
K
K
Göteborg University, Gothenburg, Sweden.
Yan
Q
Q
Yuan
X J
XJ
Kunz
H W
HW
Levan
G
G
Gill
T J
TJ
D000818:Animals; D002874:Chromosome Mapping; D005805:Genes, MHC Class I; D006128:Growth / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D008285:Major Histocompatibility Complex; D051379:Mice; D051381:Rats; D012098:Reproduction / Q000235:genetics
D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat