title: Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology.
abstract: Covalent dimers of vancomycin linked through the vancosamine sugar moieties of the glycopeptide antibiotic have been synthesized in one step in 67-69% yield. The propensity for self-association of these and related vancomycin covalent dimers is evaluated using surface plasmon resonance technology.
authors.affiliation: Department of Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA.
authors.forename: M
authors.initials: M
authors.lastname: Adamczyk
authors.forename: J A
authors.initials: JA
authors.lastname: Moore
authors.forename: S D
authors.initials: SD
authors.lastname: Rege
authors.forename: Z
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D019281:Dimerization; D011487:Protein Conformation; D020349:Surface Plasmon Resonance; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin