title: The role of early renal biopsy in cyclosporin induced thrombotic microangiopathy.
abstract: Thrombotic microangiopathy is an uncommon complication of cyclosporin immunosuppression following renal transplantation. We present a 15-year-old girl who developed clinical features of acute rejection, but in whom an early biopsy revealed thrombotic microangiopathy, allowing a change to FK506 immunosuppression resulting in excellent graft recovery.
authors.affiliation: Paediatric Department, Children's Renal Unit, The Richard Bright Kidney Unit, Southmead Hospital NHS Trust, Bristol BS10 5NB, UK,
authors.forename: G A
authors.initials: GA
authors.lastname: Burke
authors.forename: M E
authors.initials: ME
authors.lastname: McGraw
authors.forename: A G
authors.initials: AG
authors.lastname: MacIver
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000098:blood supply*; D019233:Retreatment; D016559:Tacrolimus / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus