Antibiotic hydrogel coated Foley catheters for prevention of urinary tract infection in a rabbit model.
OBJECTIVE
We developed an antibiotic liposome (ciprofloxacin liposome) containing hydrogel for external coating of silicone Foley catheters and evaluated its efficacy in a rabbit model. Our goal was to create a catheter that would hinder the development of catheter associated nosocomial urinary tract infections.


METHODS
We inserted either an untreated, liposomal hydrogel coated or a liposome hydrogel with ciprofloxacin coated 10F silicone Foley catheter into New Zealand White rabbits. We challenged the system with 5x10(6) virulent Escherichia coli at the urethral meatus twice daily for 3 days. Urine cultures were evaluated twice daily for 7 days. When urine cultures became positive, the rabbits were sacrificed and urine, urethral catheter and urethral tissue were cultured.


RESULTS
The time to bacteriuria detection in 50% of the specimens was double for hydrogel with ciprofloxacin coated catheters versus untreated and hydrogel coated catheters. A significant (p = 0.04) improvement in average time to positive urine culture from 3.5 to 5.3 days and a 30% decrease in the bacteriuria rate for hydrogel with ciprofloxacin coated catheters were noted compared to untreated catheters.


CONCLUSIONS
A significant benefit was realized by coating the extraluminal catheter surface with a ciprofloxacin liposome impregnated hydrogel. We believe this procedure will provide a significant clinical advantage, while reducing health care costs substantially.
Pugach
J L
JL
Department of Botany, Centre for Infection and Biomaterial Research, Hospital for Sick Children, University of Toronto, Ontario, Canada.
DiTizio
V
V
Mittelman
M W
MW
Bruce
A W
AW
DiCosmo
F
F
Khoury
A E
AE
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004337:Drug Carriers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D008081:Liposomes; D008297:Male; D011817:Rabbits; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000517:prevention & control*
D000890:Anti-Infective Agents; D004337:Drug Carriers; D008081:Liposomes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002939:Ciprofloxacin