Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy.
Recent neuronal activation studies on newborns using functional MRI or near infrared spectroscopy (NIRS) have suggested that the increase in O2 consumption accompanying neuronal activation exceeds the increase in O2 delivery in the visual cortex during photic stimulation. In the present study, we evaluated the cerebral blood oxygenation (CBO) changes induced by auditory stimulation in the frontal lobe of newborns using NIRS. We studied 28 newborns; the postnatal age at CBO measurements was 3.1+/-0.3 days (mean+/-S.E.M.). We measured concentration changes of deoxyhemoglobin (Deoxy-Hb), oxyhemoglobin (Oxy-Hb), and total hemoglobin (Total-Hb) induced by auditory (music) stimulation in the bilateral frontal lobes of the newborns. Twenty-six (92.9%) out of 28 subjects showed increases of Oxy-Hb and Total-Hb during the stimulation. In these subjects, 17 (60.7%) subjects showed an increase of Deoxy-Hb associated with increases of Oxy-Hb and Total-Hb, while nine (32.1%) subjects showed a decrease of Deoxy-Hb. Although the direction of the Deoxy-Hb differed, these two groups did not differ for Oxy-Hb and Total-Hb (P > 0.05). Two (7.1%) subjects showed other changes. The frontal lobe of newborns shows CBO responses similar to those observed in the visual cortex, specifically neuronal activation causes an increase of Deoxy-Hb associated with increases of Oxy-Hb and Total-Hb. These results support the hypothesis that increments in O2 consumption exceed increments in O2 delivery during neuronal activity in newborns.
Sakatani
K
K
Department of Neurosurgery, China-Japan Friendship Hospital, Hepingli, Beijing, People's Republic of China. sakatani@public.east.cn.net
Chen
S
S
Lichty
W
W
Zuo
H
H
Wang
Y P
YP
D000161:Acoustic Stimulation; D001921:Brain / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000502:physiology; D008297:Male; D010100:Oxygen / Q000097:blood* / Q000502:physiology; D010108:Oxyhemoglobins / Q000032:analysis; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin; D010100:Oxygen