Orally administered Panax ginseng extract decreases platelet adhesiveness in 66% hepatectomized rats.
The effect of oral administration of Panax ginseng extract (GE) on platelet adhesiveness was examined in 66% hepatectomized rats. A significant decrease in platelet adhesiveness was obtained when 125 mg/kg/day GE was administered for 6 days before and after hepatectomy. The total cholesterol concentration in the serum was also decreased by GE administration. Food intake was unaffected by GE administration. Serum parameters indicating liver and kidney function were unchanged after GE administration except for lipid metabolic parameters. Because enhanced platelet adhesiveness and hyperlipidemia induces atherosclerosis, these results suggest that orally administered GE is capable of improving the atherosclerotic condition associated with hepatectomy.
Cui
X
X
First Department of Surgery, Niigata University School of Medicine, Japan.
Sakaguchi
T
T
Shirai
Y
Y
Hatakeyama
K
K
D000818:Animals; D001774:Blood Chemical Analysis; D002784:Cholesterol / Q000097:blood; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006498:Hepatectomy; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008297:Male; D005894:Panax / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D010973:Platelet Adhesiveness / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol