title: Otitis media in infants aged 0-8 weeks: frequency of associated serious bacterial disease.
abstract: OBJECTIVE
  To determine the frequency of serious bacterial infection in well appearing infants aged 0-8 weeks with isolated otitis media (OM).
  
  
  METHODS
  Infants with confirmed OM underwent tympanocentesis with middle ear fluid (MEF) culture and complete sepsis evaluation. Enrolled infants were admitted to the hospital for parenteral antibiotics until blood, urine, and CSF cultures were negative for 48 hours.
  
  
  RESULTS
  Forty non-toxic appearing infants were enrolled between January 1994 and April 1995, of whom 15 (38%) had a documented rectal temperature > or =38 degrees C. Bacterial pathogens were isolated from MEF cultures in 25 (62.5%) infants. All afebrile infants had negative blood, urine, and cerebrospinal fluid cultures (upper limit (UL) 95% CI 0.11). Only two febrile infants had positive cultures from sites other than the MEF (UL 95% CI 0.36).
  
  
  CONCLUSIONS
  In our study population, previously healthy, non-toxic appearing afebrile infants aged 2-8 weeks and having isolated OM infrequently have an associated serious bacterial infection, suggesting that outpatient treatment with oral antibiotics and close follow-up may be an option. Further studies with large numbers of infants are necessary to confirm this conclusion.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Milwaukee, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Nozicka
authors.forename: J G
authors.initials: JG
authors.lastname: Hanly
authors.forename: D J
authors.initials: DJ
authors.lastname: Beste
authors.forename: S F
authors.initials: SF
authors.lastname: Conley
authors.forename: H M
authors.initials: HM
authors.lastname: Hennes
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000150:complications / Q000453:epidemiology*; D001826:Body Fluids / Q000382:microbiology; D004432:Ear, Middle / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010033:Otitis Media / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D015995:Prevalence; D011446:Prospective Studies; D018805:Sepsis / Q000150:complications / Q000453:epidemiology*
chemical_list: D000900:Anti-Bacterial Agents