title: Mid-dermal elastolysis associated with Hashimoto's thyroiditis.
abstract: We report the case of a 38-year-old Caucasian female presenting asymptomatic plaques of fine wrinkling and perifollicular papular protrusions especially on the trunk. Histological examination evidenced loss of elastic fibers in the mid-dermis due to elastophagocytosis, with giant cells and granuloma formation. Moreover, elevated titers of thyroid autoantibodies were detected and thyroid ultrasound revealed echo-poor tissue. These findings met the diagnoses of mid-dermal elastolysis and Hashimoto's thyroiditis. This association has not been reported before. We present a comprehensive overview of the literature and discuss the pathogenetic aspects of mid-dermal elastolysis and the significance of the association with Hashimoto's thyroiditis.
authors.affiliation: Department of Dermatology, J.W. Goethe University, Frankfurt/Main, Germany. erik.senger@t-online.de
authors.forename: T
authors.initials: T
authors.lastname: Gambichler
authors.forename: C
authors.initials: C
authors.lastname: Linhart
authors.forename: M
authors.initials: M
authors.lastname: Wolter
mesh_terms: D000328:Adult; D003240:Connective Tissue Diseases / Q000150:complications* / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000150:complications / Q000473:pathology; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000473:pathology