title: Persistence of iodine deficiency 25 years after initial correction efforts in the Khumbu region of Nepal.
abstract: OBJECTIVE
  To assess the current status of, and understanding about iodine deficiency disorders among Sherpa residents of the Khumbu region of Nepal, 25 years after the introduction of iodised oil injections.
  
  
  METHODS
  Several groups of Khumbu Sherpas were studied and goitre rate, urinary iodine level and cretinism prevalence were measured as indicators of iodine deficiency. Subjects were also questioned in detail about their food consumption, with particular reference to salt use, and about their understanding of the causes and treatment of iodine deficiency disorders.
  
  
  RESULTS
  The prevalences of goitre, deaf-mutism and cretinism were 21%, 1.3% and 0.5% respectively (compared to 92%, 4.7% and 5.9% in 1966). No cretins had been born since 1966. The median urine iodine concentration was 35 microg/L. Most people preferred uniodised Tibetan rock salt, although 44% regularly consumed iodised salt. All granulated salt tested from the local market contained adequate amounts of iodine. Only 11% of those surveyed knew that goitre was caused by iodine deficiency
  
  
  CONCLUSIONS
  Although prevalences of iodine deficiency disorders are much less than 30 years ago, iodine deficiency continues to be a major problem in Khumbu and demands a clear control strategy, combining ongoing iodine supplementation and education. Iodised salt is usually the best approach to control of iodine deficiency disorders for most regions of the world but the Khumbu experience shows that local cultural and commercial factors can severely limit its impact. To be successful, control programme for iodine deficiency disorders also needs assessment of the salt trade, monitoring, education and occasional targeted interventions with iodised oil or other supplements.
authors.affiliation: Kunde Hospital, Solukhumbu District, Nepal. murdo005@mc.duke.edu
authors.forename: D R
authors.initials: DR
authors.lastname: Murdoch
authors.forename: E G
authors.initials: EG
authors.lastname: Harding
authors.forename: J T
authors.initials: JT
authors.lastname: Dunn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000453:epidemiology* / Q000517:prevention & control; D003677:Deficiency Diseases / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D006043:Goiter, Endemic / Q000453:epidemiology* / Q000517:prevention & control; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007223:Infant; D007455:Iodine / Q000172:deficiency* / Q000627:therapeutic use / Q000652:urine; D008297:Male; D008875:Middle Aged; D009390:Nepal / Q000453:epidemiology; D015995:Prevalence; D012720:Severity of Illness Index; D017673:Sodium Chloride, Dietary; D018709:Statistics, Nonparametric
chemical_list: D017673:Sodium Chloride, Dietary; D007455:Iodine