title: Hepatic lipidosis associated with cobalt deficiency in Omani goats.
abstract: Livers from 36 of 684 (5.3%) apparently healthy goats examined at an abattoir in the greater Muscat area of Oman exhibited gross pathological findings characterized by extremely pale, friable, fatty livers encompassing the entire organ. Histopathologically, diffuse hepatic lipidosis and occasional bile duct proliferation were observed. Periodic acid Schiff-positive, diastase-resistant pigment was observed in the macrophages lining the sinusoids. These histopathological lesions were consistent with those characteristic of ovine white liver disease. Cobalt analysis revealed that normal livers had six times more cobalt and a 3-fold less fat content than those measured in the fatty livers. This is the first report of an association between cobalt deficiency and hepatic lipidosis in Omani goats.
authors.affiliation: Sultan Qaboos University, College of Agriculture, Department of Animal and Veterinary Sciences, Muscat, Sultanate of Oman.
authors.forename: E H
authors.initials: EH
authors.lastname: Johnson
authors.forename: D E
authors.initials: DE
authors.lastname: Muirhead
authors.forename: K
authors.initials: K
authors.lastname: Annamalai
authors.forename: G J
authors.initials: GJ
authors.lastname: King
authors.forename: R
authors.initials: R
authors.lastname: Al-Busaidy
authors.forename: M S
authors.initials: MS
authors.lastname: Hameed
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000473:pathology; D003035:Cobalt / Q000032:analysis* / Q000172:deficiency*; D003677:Deficiency Diseases / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D015511:Goat Diseases / Q000473:pathology*; D006041:Goats; D008064:Lipidoses / Q000473:pathology / Q000662:veterinary*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000737:chemistry / Q000166:cytology / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology / Q000662:veterinary*; D009850:Oman; D012756:Sheep
chemical_list: D008055:Lipids; D003035:Cobalt