title: Quinoline alkaloids from Acronychia laurifolia.
abstract: Bioassay-directed fractionation of a root extract of Acronychia laurifolia (Rutaceae) using the KB-V1+ human tumor cell line led to the isolation of six quinoline alkaloids. One of these alkaloids is novel, namely, 2,3-methylenedioxy-4,7-dimethoxyquinoline and the other five were identified as the known compounds, evolitrine, gamma-fagarine, skimmianine, kokusaginine and maculosidine. Two known bis-tetrahydrofuran lignans, sesamolin and yangambin, were also identified. The structure of the new alkaloid was determined by spectroscopic methods. All of the isolates were evaluated against a panel of human cancer cell lines; four of the alkaloids showed weak cytotoxic activity.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
authors.forename: B
authors.initials: B
authors.lastname: Cui
authors.forename: H
authors.initials: H
authors.lastname: Chai
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
authors.forename: F D
authors.initials: FD
authors.lastname: Horgen
authors.forename: B
authors.initials: B
authors.lastname: Hansen
authors.forename: D A
authors.initials: DA
authors.lastname: Madulid
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010944:Plants / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D011804:Quinolines