Vascular remodeling in hypertensive transgenic mice.
We physiologically and histopathologically analyzed vascular damage due to hypertension and vascular remodeling in hypertensive transgenic mice (Tsukuba hypertensive mice; THM). Pubertal (6-week-old) THM already had hypertension similar to blood pressure in adult THM due to an enhanced renin angiotensin system (RAS). They progressively developed remarkable vascular hypertrophy composed of dedifferentiation of vascular smooth muscle cells (VSMCs) and extracellular matrix accumulation in the thoracic aorta, and VSMC hyperplasia was predominant in the abdominal aorta. THM are therefore a useful animal model for studying vascular remodeling mediated by enhanced RAS.
Nishijo
N
N
Laboratory Animal Research Center, University of Tsukuba, Ibaraki, Japan.
Takamine
S
S
Sugiyama
F
F
Kimoto
K
K
Taniguchi
K
K
Horiguchi
H
H
Ogata
T
T
Murakami
K
K
Fukamizu
A
A
Yagami
K
K
D000450:Aldosterone / Q000652:urine; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000503:physiopathology; D001013:Aorta, Thoracic / Q000473:pathology / Q000503:physiopathology; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006965:Hyperplasia / Q000473:pathology; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D006984:Hypertrophy / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000503:physiopathology*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology
D000450:Aldosterone; D012083:Renin