title: Papillary renal cell carcinoma with clear cell cytomorphology and chromosomal loss of 3p.
abstract: OBJECTIVE
  Cytogenetic studies on renal cell carcinomas (RCCs) have disclosed a correlation between chromosome aberrations and histomorphological features. Nevertheless, it is still controversial whether the cytomorphology of the tumour cells (clear cell, chromophilic, chromophobe) or their growth pattern (nonpapillary, papillary) is more discriminative for the combined histomorphological-cytogenetic classification of RCCs.
  
  
  RESULTS
  Three RCCs with papillary growth pattern and clear cell cytomorphology were analysed by classical cytogenetics using standard G-banding techniques. Each tumour displayed clonal aberrations leading to loss of terminal 3p chromosomal segments. Monosomy 14 was also consistently found. Trisomy 17 was not observed in any of the tumours.
  
  
  CONCLUSIONS
  This series of three RCCs consisting of clear cells with papillary architecture revealed chromosomal aberrations characteristic for the conventional (clear cell) RCC. Irrespective of the predominant papillary growth pattern, none of the cases were characterized by trisomy of chromosomes 3q, 7, 8, 12, 16, 17 and 20 and loss of Y chromosome which are widely regarded as the most consistent genetic alterations for papillary RCC. Therefore, our cytogenetic findings provide evidence that papillary clear cell RCCs should be classified according to their cytomorphology rather than their growth pattern even when papillary architecture is prominent.
authors.affiliation: Institute of Pathology, Medical School of the Technical University, Aachen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Füzesi
authors.forename: B
authors.initials: B
authors.lastname: Gunawan
authors.forename: F
authors.initials: F
authors.lastname: Bergmann
authors.forename: S
authors.initials: S
authors.lastname: Tack
authors.forename: S
authors.initials: S
authors.lastname: Braun
authors.forename: G
authors.initials: G
authors.lastname: Jakse
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D009006:Monosomy