Histological demonstration of haemosiderin deposits in lungs and liver from victims of chronic physical child abuse.
In the context of chronic physical child abuse, two entities have been described based on macroscopical and radiological criteria: the battered baby syndrome and the shaken baby syndrome. However, in some autopsy cases, clinico-radiological information may not be available. In these cases, histological examinations are necessary to look for sequelae of repeated haemorrhages, particularly in organs likely to have suffered traumatisms such as the lungs, or in organs belonging to the mononucleated macrophage resorption system, such as the liver and the spleen. We examined a series of 15 young children who died from proven chronic child abuse and compared them with 15 sex and age-matched control subjects who died from natural causes with no history of child abuse. Using Perl's stain for iron, we identified haemosiderin deposits in pulmonary, hepatic and splenic samples and the deposits were evaluated qualitatively and quantitatively. Haemosiderin deposits were significantly (P < 0.001) more abundant in the lungs and liver of the chronic abuse victims than in those of the control subjects. However, they were not significantly more abundant in the spleens of child abuse victims than in controls. We conclude that haemosiderin deposits in lungs and liver could be proposed as a marker for chronic physical child abuse. This study stresses the importance of systematic histological examination to look for pulmonary and hepatic haemosiderin deposits in cases in which chronic child abuse is suspected.
Dorandeu
A
A
Department of Pathology and Forensic Medicine, Hôpital Raymond Poincaré, 104 boulevard R. Poincaré, F-92380, Garches, France. anapath.garches@rpc.ap-hop-paris.fr
Perie
G
G
Jouan
H
H
Leroy
B
B
Gray
F
F
Durigon
M
M
D001497:Battered Child Syndrome / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D002649:Child Abuse / Q000175:diagnosis / Q000331:legislation & jurisprudence*; D002675:Child, Preschool; D005260:Female; D006485:Hemosiderin / Q000032:analysis*; D006486:Hemosiderosis / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000473:pathology*; D008297:Male; D012680:Sensitivity and Specificity
D015415:Biomarkers; D006485:Hemosiderin