title: Use of high-resolution techniques for the characterization of clotting factor VIII.
abstract: Dealing with the structural characterization of clotting factor VIII (FVIII) requires the application of several high-resolution analytical techniques. Besides the analytical point of view, a detailed knowledge of FVIII structure, production and therapeutic application is necessary. This review gives an overview of most of the currently applied analytical methods and how they deal with the complex analytical problem, investigating FVIII in a sample matrix containing large amounts of accompanying plasma proteins.
authors.affiliation: Octapharma Pharmazeutika Produktionsges.m.b.H., Vienna, Austria. katharina.pock@octapharma.at
authors.forename: K
authors.initials: K
authors.lastname: Pock
authors.forename: A
authors.initials: A
authors.lastname: Rizzi
authors.forename: D
authors.initials: D
authors.lastname: Josic
mesh_terms: D005169:Factor VIII / Q000737:chemistry*; D006801:Humans
chemical_list: D005169:Factor VIII