title: Factor VIII inhibitors in patients with hemophilia A.
abstract: In 58 hemophilia A patients aged 1-18 years (mean 9.5 +/- 4.7 years), the prevalence of inhibitors was found to be 27% by the Bethesda method in November 1995. Inhibitor activity was not detected in any of 14 patients with mild hemophilia while it was present in 9 of 27 (33%) patients with moderate, and 7 of 17 (41%) with severe disease. During follow-up, the inhibitors were transient in 10 of 16 patients (17%) and the prevalence of inhibitors was 10% at the end of the study. Our study has demonstrated that the patients' age, factor VIII (F VIII) coagulant activity levels, type of F VIII replacement therapy, and frequency of F VIII administration affect inhibitor development, and these factors should be considered in the follow-up of hemophiliacs.
authors.affiliation: Department of Pediatric Hematology, Dokuz Eylül University, Faculty of Medicine, Izmir, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Oren
authors.forename: I
authors.initials: I
authors.lastname: Yaprak
authors.forename: G
authors.initials: G
authors.lastname: Irken
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007223:Infant
chemical_list: D005169:Factor VIII