title: Development of design methods for a centrifugal blood pump with a fluid dynamic approach: results in hemolysis tests.
abstract: The purpose of this study was to examine the relationship between local flow conditions and the hemolysis level by integrating hemolysis tests, flow visualization, and computational fluid dynamics to establish practical design criteria for centrifugal blood pumps with lower levels of hemolysis. The Nikkiso centrifugal blood pump was used as a standard model, and pumps with different values of 3 geometrical parameters were tested. The studied parameters were the radial gap between the outer edge of the impeller vane and the casing wall, the position of the outlet port, and the discharge angle of the impeller vane. The effect of a narrow radial gap on hemolysis was consistent with no evidence that the outlet port position or the vane discharge angle affected blood trauma in so far as the Nikkiso centrifugal blood pump was concerned. The radial gap should be considered as a design parameter of a centrifugal blood pump to reduce blood trauma.
authors.affiliation: Department of Mechanical Engineering, Ibaraki University, Hitachi, Japan. masuzawa@mech.ibaraki.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: T
authors.initials: T
authors.lastname: Tsukiya
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: B
authors.initials: B
authors.lastname: Asztalos
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazoe
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Sawairi
authors.forename: Y
authors.initials: Y
authors.lastname: Konishi
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004867:Equipment Design; D005112:Extracorporeal Circulation / Q000295:instrumentation*; D006041:Goats; D006353:Heart-Assist Devices; D006461:Hemolysis; D066298:In Vitro Techniques; D012212:Rheology