title: Loss of maternal allele in a child with myelodysplastic syndrome and monosomy 7.
abstract: Monosomy 7 or partial deletion of the long arm of chromosome 7 is frequently described in children with myelodysplastic syndrome and acute myeloblastic leukemia. Parental origin of chromosome 7 in children with sporadic monosomy 7 has been examined very rarely. To investigate if monosomy 7 shows parent-of-origin, we have studied a female child with monosomy 7 and de novo myelodysplastic syndrome by a series of polymorphic polymerase chain reaction markers. We found loss of maternal allele and discussed the results with the previous reports.
authors.affiliation: Department of Genetics, Hacettepe University, Ihsan Dogramaci Children's Hospital, 06100 Sihhiye, Ankara, Turkey. daktas@genetic.gen.hun.ed
authors.forename: D
authors.initials: D
authors.lastname: Aktas
authors.forename: I
authors.initials: I
authors.lastname: Yenicesu
authors.forename: G
authors.initials: G
authors.lastname: Hicsonmez
authors.forename: E
authors.initials: E
authors.lastname: Tuncbilek
mesh_terms: D000483:Alleles; D002675:Child, Preschool; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D009006:Monosomy; D009030:Mosaicism; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D016133:Polymerase Chain Reaction