Neurohormonal Signaling Pathways and the Regulation of Alzheimer beta-Amyloid Precursor Metabolism.
Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half. Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.
Gandy
S
Department of Psychiatry, New York University, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA and the Fisher Center for Alzheimer Research, The Rockefeller University, New York, NY 10021, USA.