A follow-up study of the acute behavioral effects of benzodiazepine-receptor ligands in humans: comparison of quazepam and triazolam.
Quazepam, a trifluoroethylbenzodiazepine hypnotic, and triazolam, a triazolobenzodiazepine hypnotic, differ in terms of their benzodiazepine-receptor binding profile. Previous studies have suggested that quazepam produces less performance impairment than triazolam. Whether these effects are due to differences between quazepam and triazolam in terms of their benzodiazepine-receptor binding profile or to the testing of insufficient doses is unknown. The present study compared the acute behavioral effects of triazolam (0.1875, 0.3750, and 0.5625 mg), quazepam (30, 60, and 90 mg), and placebo in 12 healthy humans using a within-subjects, placebo-controlled, crossover design. Quazepam and triazolam produced comparable dose-dependent performance impairment and increased ratings of drug effect and drowsy. Quazepam, but not triazolam, increased ratings of dizzy/light-headed, performance impaired, and sleepy. Triazolam, but not quazepam, increased ratings of high. Thus, across a sufficient range of doses, the performance-impairing effects of quazepam were similar to those of triazolam. By contrast, quazepam and triazolam produced somewhat different constellations of participant-rated drug effects. These differential drug effects may be attributable to differences between quazepam and triazolam in terms of their benzodiazepine-receptor binding profile.
Rush
C R
CR
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, USA. CRush41165@aol.com
Ali
J A
JA
D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001519:Behavior / Q000187:drug effects*; D001569:Benzodiazepines; D003071:Cognition / Q000187:drug effects; D018592:Cross-Over Studies; D005260:Female; D005500:Follow-Up Studies; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D007858:Learning / Q000187:drug effects; D008024:Ligands; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects; D011963:Receptors, GABA-A / Q000187:drug effects*; D011795:Surveys and Questionnaires; D014229:Triazolam / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D018757:GABA Modulators; D008024:Ligands; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D014229:Triazolam; C025130:quazepam