title: Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1.
abstract: We report on a male Japanese patient with hairy cell leukemia (HCL). A cytogenetic study with lipopolysaccharide stimuli showed a novel translocation (11;20)(q13;q11) in 10% of the analyzed cells. Northern blot analysis and RT-PCR analysis for cyclin D1 revealed the overexpression of cyclin D1, although the southern blot analysis of PRAD1 gene showed no rearrangement. In this particular case, the t(11;20)(q13;q11) might play some role in the oncogenesis of HCL and the overexpression of cyclin D1.
authors.affiliation: Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. fumishi@hsp.md.shinshu-u.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Kitano
authors.forename: N
authors.initials: N
authors.lastname: Ichikawa
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Kohara
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Motokura
authors.forename: K
authors.initials: K
authors.lastname: Kiyosawa
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002890:Chromosomes, Human, Pair 20; D019938:Cyclin D1 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
chemical_list: D019938:Cyclin D1