Ketamine suppresses c-fos expression in dorsal horn neurons after acute constrictive sciatic nerve injury in the rat.
Fos immunoreactivity within the spinal cord in a model of neuropathic pain was studied. Dorsal horn neurons in laminae I and II exhibited selective expression within the tibial, peroneal and posterior cutaneous nerve territories which, in turn, was suppressed during ketamine but not halothane anesthesia. Fos immunoreactive neurons have a unique response pattern to neuropathic pain which is sensitive to ketamine.
Huang
W
W
Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
Simpson
R K
RK
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology; D006614:Hindlimb; D007649:Ketamine / Q000494:pharmacology*; D008959:Models, Neurological; D009409:Nerve Crush; D009437:Neuralgia / Q000503:physiopathology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries / Q000502:physiology* / Q000503:physiopathology; D012867:Skin / Q000294:innervation; D013116:Spinal Cord / Q000502:physiology* / Q000503:physiopathology
D016760:Proto-Oncogene Proteins c-fos; D007649:Ketamine; D006221:Halothane