Menstrual and reproductive factors for salivary gland cancer risk in women.
Several observations suggest that salivary gland cancer may be, in part, a hormonally dependent disease. We examined associations between hormonally mediated life events and salivary gland cancer risk in a population-based case-control study. Of 76 women diagnosed between 1989 and 1993, 63 (83%) were interviewed. Of 111 population controls, 83 (75%) were interviewed. Early menarche (OR = 4.1, 95% CI = 1.4-12.1) and nulliparity (OR = 2.6, 95% CI = 1.0-6.7) were associated with increased risk whereas late age at first full-term pregnancy (OR = 0.19, 95% CI = 0.3-1.2) and longer duration of oral contraceptive use (OR = 0.31, 95% CI = 0.10-1.0) were associated with diminished risk. These findings are consistent with a hormonal component in salivary gland cancer risk.
Horn-Ross
P L
PL
Northern California Cancer Center, Union City 94587-3106, USA.
Morrow
M
M
Ljung
B M
BM
D000328:Adult; D000368:Aged; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D002979:Climacteric; D005260:Female; D006801:Humans; D008572:Menarche; D008597:Menstrual Cycle; D008875:Middle Aged; D011247:Pregnancy; D017584:Reproductive History; D012307:Risk Factors; D012468:Salivary Gland Neoplasms / Q000453:epidemiology / Q000209:etiology*; D013223:Statistics as Topic