The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.
The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.
Chung
W K
WK
Columbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY 10032, USA.
Luke
A
A
Cooper
R S
RS
Rotini
C
C
Vidal-Puig
A
A
Rosenbaum
M
M
Gordon
D
D
Leal
S M
SM
Caprio
S
S
Goldsmith
R
R
Andreu
A L
AL
Bruno
C
C
DiMauro
S
S
Heo
M
M
Lowe
W L
WL
Lowell
B B
BB
Allison
D B
DB
Leibel
R L
RL
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology*; D005091:Exons; D006706:Homeostasis; D006801:Humans; D007473:Ion Channels; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins; D009154:Mutation; D009765:Obesity / Q000235:genetics / Q000503:physiopathology; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3