title: Clinical use of topical retinaldehyde on photoaged skin.
abstract: BACKGROUND
  Retinaldehyde, the natural precursor of retinoic acid, should exert similar effects on photoaged skin.
  
  
  OBJECTIVE
  To establish the efficacy and safety of topical retinaldehyde on photoaged skin.
  
  
  METHODS
  Open and controlled clinical studies using image analysis of silicone skin replicas.
  
  
  RESULTS
  Retinaldehyde proved efficient and safe.
  
  
  CONCLUSIONS
  Retinaldehyde is efficient and well tolerated for the improvement of the signs of photoaging.
authors.affiliation: Department of Dermatology, Hôpital Saint-Jacques, Besançon, France.
authors.forename: P
authors.initials: P
authors.lastname: Creidi
authors.forename: P
authors.initials: P
authors.lastname: Humbert
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D012172:Retinaldehyde / Q000008:administration & dosage*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D012172:Retinaldehyde