Treatment of obstructive sleep apnea syndrome with a Kampo-formula, San'o-shashin-to: a case report.
The following describes a 76-year-old male with obstructive sleep apnea syndrome successfully treated with a Kampo-formula, San'o-shashin-to (Formula medicamentorum tres ad dispellendi cordis). Polysomnography, performed before and after administration of San'o-shashin-to, revealed that the apnea index decreased from 11.1 events/hour to 4.1 events/hour, and that the apnea plus hypopnea index decreased from 18.4 events/hour to 10.7 events/hour. The patient was normo-weight (body mass index: 20.4 kg/m2), and events of sleep apnea and hypopnea were mostly noted during a non-rapid eye movement sleep. It is possible that San'o-shashin-to has some alleviating effects on the upper airway resistance during sleep.
Hisanaga
A
A
Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Saitoh
O
O
Fukuda
H
H
Kurokawa
K
K
Okabe
A
A
Tachibana
H
H
Hagino
H
H
Mita
T
T
Yamashita
I
I
Tsutsumi
M
M
Kurachi
M
M
Itoh
T
T
D000368:Aged; D001143:Arousal / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D017286:Polysomnography / Q000187:drug effects; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000209:etiology; D012894:Sleep Stages / Q000187:drug effects; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal