title: Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.
abstract: Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.
authors.affiliation: Taub Alzheimer's Disease Research Center, Staten Island, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mayeux
authors.forename: M X
authors.initials: MX
authors.lastname: Tang
authors.forename: D M
authors.initials: DM
authors.lastname: Jacobs
authors.forename: J
authors.initials: J
authors.lastname: Manly
authors.forename: K
authors.initials: K
authors.lastname: Bell
authors.forename: C
authors.initials: C
authors.lastname: Merchant
authors.forename: S A
authors.initials: SA
authors.lastname: Small
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: H M
authors.initials: HM
authors.lastname: Wisniewski
authors.forename: P D
authors.initials: PD
authors.lastname: Mehta
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C098994:amyloid beta-protein (1-43)