title: Effect of an alpha(2) agonist (mivazerol) on limiting myocardial ischaemia in stable angina.
abstract: A specific alpha(2) agonist, mivazerol, known to be effective in reducing myocardial ischaemia when given intravenously immediately before an exercise tolerance test, produced a significant increase in exercise duration and time to the onset of angina when given orally over a two week period to 25 patients with stable angina. A non-significant trend to reduction in electrocardiographic signs of ischaemia was also noted. The clinical relevance of this improvement now needs to be tested in larger numbers.
authors.affiliation: Department of Cardiology, Royal Brompton and Harefield NHS Trust, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Fox
authors.forename: H J
authors.initials: HJ
authors.lastname: Dargie
authors.forename: D P
authors.initials: DP
authors.lastname: de Bono
authors.forename: M F
authors.initials: MF
authors.lastname: Oliver
authors.forename: E
authors.initials: E
authors.lastname: Wülfert
authors.forename: T
authors.initials: T
authors.lastname: Kharkevitch
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D017202:Myocardial Ischemia / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; C087969:mivazerol