title: Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.
abstract: We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep-onset rapid eye movement (REM) periods in the multiple sleep latency test. Unbearable daytime sleepiness occurred abruptly, which usually led to short-lasting naps, after which the patients felt refreshed. The EDS was successfully reduced by treatment with methylphenidate. In spite of these features similar to narcolepsy, these cases of REM hypersomnia did not present cataplexy or other auxiliary symptoms of narcolepsy, and, furthermore, the class-II human leukocyte antigen DR2 appeared to be negative.
authors.affiliation: Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kuroda
authors.forename: M
authors.initials: M
authors.lastname: Mandai
authors.forename: S
authors.initials: S
authors.lastname: Satani
authors.forename: N
authors.initials: N
authors.lastname: Emura
authors.forename: S
authors.initials: S
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Matsumura
authors.forename: H
authors.initials: H
authors.lastname: Yoneda
mesh_terms: D000328:Adult; D000697:Central Nervous System Stimulants / Q000008:administration & dosage; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D003937:Diagnosis, Differential; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D004576:Electromyography / Q000187:drug effects; D015802:HLA-DR2 Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage; D009290:Narcolepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D017286:Polysomnography; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology
chemical_list: D000697:Central Nervous System Stimulants; D015802:HLA-DR2 Antigen; D008774:Methylphenidate