Significance of the anti-E2 response in self-limited and chronic hepatitis C virus infections in chimpanzees and in humans.
To determine whether there was a correlation between the kinetics or frequency of antibody to mammalian-derived hepatitis C virus (HCV) second envelope protein (E2) and development of chronicity or self-limitation of HCV infections, serial sera were examined for anti-E2, anti-HCV with confirmation with Matrix 2.0 (Abbott Laboratories, Abbott Park, IL), and reverse transcriptase-polymerase chain reaction (RT-PCR) from 6 cases of self-limited infection and 6 cases of chronic infection in chimpanzees, and from 5 cases of self-limited infection and 3 cases of chronic infection in patients. Anti-E2 developed earlier, more frequently, and to higher titer in chimpanzees and patients who were developing chronic infection than in those with self-limited infections. Thus anti-E2 is unlikely to play a role in self-limitation of the infection. However, long-term persistence of anti-E2 correlates with chronic infection. There was little or no correlation between the timing of development of anti-E2 and anti-HCV.
Prince
A M
AM
New York Blood Center, New York, NY 10021, USA. aprince@NYBC.org
Brotman
B
B
Lee
D H
DH
Ren
L
L
Moore
B S
BS
Scheffel
J W
JW
D000818:Animals; D001803:Blood Transfusion; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D002679:Pan troglodytes; D011446:Prospective Studies; D013997:Time Factors; D014759:Viral Envelope Proteins / Q000276:immunology*
D018937:Hepatitis C Antibodies; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus