title: Exchange transfusion treatment in a newborn with phenobarbital intoxication.
abstract: A comatose, 14-day-old boy was referred to our emergency department (ED) after an overdose of phenobarbital, which was used for the treatment of long-standing jaundice. Plasma phenobarbital concentration was 112.4 microg/ml before treatment. One hour after giving albium transfusion, an exchange transfusion, which took about 45 minutes, was performed. Volume of exchange was 400 ml (volume of exchange (ml) = 2 x 85 ml/kg). After the exchange transfusion, the phenobarbital concentration decreased to 50.84 microg/ml. At clinical and laboratory follow-up, the patient recovered fully. This case suggests that exchange transfusion is an effective and successful treatment for phenobarbital intoxication in newborn.
authors.affiliation: Ondokuz Mayis University School of Medicine, Department of Pediatrics, Samsun, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Sancak
authors.forename: S
authors.initials: S
authors.lastname: Küçüködük
authors.forename: H A
authors.initials: HA
authors.lastname: Taşdemir
authors.forename: N
authors.initials: N
authors.lastname: Belet
mesh_terms: D000328:Adult; D062787:Drug Overdose / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000188:drug therapy; D008297:Male; D008508:Medication Errors; D010634:Phenobarbital / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy
chemical_list: D010634:Phenobarbital