Blockade of dopamine D2, but not of D1 receptors in the rat globus pallidus induced Fos-like immunoreactivity in the caudate-putamen, substantia nigra and entopeduncular nucleus.
In the present study, we investigated Fos-like immunoreactivity (FLI) evoked by pallidal dopamine (DA) D1 and D2 receptor blockade in the caudate-putamen (CPu), substantia nigra (SN) and entopeduncular nucleus (EP), i.e. major target areas of pallidal efferents. Results demonstrate that infusion of the selective D1 antagonist SCH23390 (1 and 4 microg/0.5 microl) into the globus pallidus (GP) did not induce FLI in the CPu, SN and EP. In contrast, intrapallidal infusion of a low dose of the selective D2 antagonist S(-)-sulpiride (15 microg/0.5 microl) induced FLI restricted to the CPu. A higher dose of intrapallidal S(-)-sulpiride (25 microg/0.5 microl) induced FLI in the CPu as well as in the SN and EP. These findings add further evidence to notion that the GP plays a central role in the basal ganglia circuitry and demonstrate an involvement of extrastriatal DA via D2 receptors.
Hauber
W
W
Abteilung Tierphysiologie, Biologisches Institut, Universität Stuttgart, Germany. hauber@po.uni-stuttgart.de
Lutz
S
S
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005917:Globus Pallidus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000276:immunology / Q000378:metabolism*; D011699:Putamen / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism
D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D016760:Proto-Oncogene Proteins c-fos; D017447:Receptors, Dopamine D1