title: Drug related negative side-effects is a common reason for poor compliance in hormone replacement therapy.
abstract: OBJECTIVE
  The reasons for poor compliance with hormone replacement therapy (HRT) and, in particular drug-related reasons, have not yet been fully elucidated. In this study, a cohort of peri- or postmenopausal women--mainly workers from a small town and surrounding rural area--was studied. The aim of the study was to investigate why some women never start or discontinue HRT, even when great effort has been made to inform and fulfill the demands of the patient.
  
  
  METHODS
  All women who were given a HRT prescription at a gynecological practice between September 1991 and December 1992 participated in a longitudinal study. A written questionnaire was mailed to these patients in 1996. Data from the questionnaire was supplemented with information from the medical records. Care of patients included initial information, follow-up within 4 months, yearly visits supplemented with contacts on demand.
  
  
  RESULTS
  356 women received the questionnaire, among which 92% replied. A total of 2% never started HRT. Seventy-five percent continued the therapy for more than 3 years. Reasons for discontinuing HRT were negative side-effects (35%), desire to find out if climacteric symptoms had ended (26%), fear of cancer and thrombosis (25%), weariness of bleeding (19%) and a wish to deal with the problems 'naturally' (15%).
  
  
  CONCLUSIONS
  Compliance with HRT can be high if adequate information is given and follow-ups are made. The main reason for poor compliance was negative side-effects, most likely progestin-related. The results of this study suggest that the future challenge will be to minimize negative side-effects of HRT.
authors.affiliation: Department of Obstetrics and Gynecology, Umeå University Hospital, Sweden. inger.bjorn@tea.mail.telia.com
authors.forename: I
authors.initials: I
authors.lastname: Björn
authors.forename: T
authors.initials: T
authors.lastname: Bäcksröm
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D017698:Postmenopause; D011795:Surveys and Questionnaires; D013548:Sweden; D016312:Treatment Refusal