title: Pigmented central neurocytoma: case report and literature review.
abstract: A case of pigmented central neurocytoma is reported. The tumor showed histologic, immunophenotypic, and ultrastructural features of central neurocytoma. The pigment consisted of an intimate association of lipofuscin and neuromelanin. Pigmented neuroepithelial tumors are rare, and the pigments may be neuromelanin or melanin. Pigmented central neurocytoma has not been described to date. The low proliferation rate of the tumor suggests a delayed turnover of tumor cells as a possible cause of lipofuscin accumulation. Autocatalytic peroxidation of lipofuscin is a possible mechanism of neuromelanin formation.
authors.affiliation: Department of Tissue Pathology, Westmead Hospital, Sydney, Australia.
authors.forename: T H
authors.initials: TH
authors.lastname: Ng
authors.forename: A Y
authors.initials: AY
authors.lastname: Wong
authors.forename: R
authors.initials: R
authors.lastname: Boadle
authors.forename: J S
authors.initials: JS
authors.lastname: Compton
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology; D002455:Cell Division; D006801:Humans; D008062:Lipofuscin; D008297:Male; D018306:Neurocytoma / Q000473:pathology / Q000503:physiopathology
chemical_list: D008062:Lipofuscin