title: [Bone marrow recovery after irradiation of the spine].
abstract: BACKGROUND
  Imaging of bone marrow by radio labeled antibodies against NCA-95 antigen of human granulocytes offers the possibility to visualize granulopoietic activity. After radiotherapy, a reduced uptake delineates the radiation field. Aim of our investigation was the study of strength and duration of this effect.
  
  
  METHODS
  We analyzed 80 cases of patients irradiated for different primary or metastatic malignancies including parts of the spine who received a bone marrow scan for re-staging or during follow-up. Activity uptake of vertebrae inside and outside the irradiation portal was evaluated by ROI and the ratio was taken as measure of bone marrow suppression.
  
  
  RESULTS
  A depression of granulopoietic bone marrow activity was seen even after a few fractions of 1.8 or 2 Gy (Figure 1). Depending on time since irradiation (Figure 2), we found a bone marrow recovery. In patients without bone metastasis, regeneration could be complete, whereas in patients treated for metastases, it was incomplete in all cases (Figure 3).
  
  
  CONCLUSIONS
  For a certain time after irradiation, radioimmunoimaging delineates the irradiation portal by showing depression of granulopoiesis. Later on, it also shows bone marrow regeneration after radiotherapy. This may be helpful in reconstruction of radiation portals or in toxicity estimation during multimodal cancer therapy.
authors.affiliation: Klinik für Strahlentherapie, Rheinisch-Westfälischen Technischen Hochschule Aachen. Ursula.Schleicher@post.rwth-aachen.de
authors.forename: U M
authors.initials: UM
authors.lastname: Schleicher
authors.forename: B M
authors.initials: BM
authors.lastname: Dohmen
authors.forename: S
authors.initials: S
authors.lastname: Gripp
authors.forename: R
authors.initials: R
authors.lastname: Bares
authors.forename: U
authors.initials: U
authors.lastname: Büll
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000528:radiation effects*; D005260:Female; D006098:Granulocytes / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D013997:Time Factors