title: Total Synthesis of Quinoxapeptin A-C: Establishment of Absolute Stereochemistry.
abstract: The relative and absolute stereochemistry of the naturally occurring potent HIV reverse transcriptase (RT) inhibitors 1 and 2, quinoxapeptin A and B, were established by total synthesis. Their synthetic precursor 3 (dubbed quinoxapeptin C) was found to be a more potent HIV-1 RT inhibitor and to lack the potent cytotoxic activity characteristic of 1 and 2.
authors.affiliation: Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors.initials: DL
authors.lastname: Boger
authors.initials: MW
authors.lastname: Ledeboer
authors.initials: M
authors.lastname: Kume
authors.initials: Q
authors.lastname: Jin