title: [Giant condylomata acuminata (Buschke-Löwenstein tumor)].
abstract: METHODS
  A 59-year-old woman had for 3 weeks been suffering from painful, moist skin changes on the external genitals, for 3 months having noticed vegetations in the anogenital and perineal region. She had been fatigued and lacking in energy since then. Her last gynecological examination had been 20 years ago. Examination of the skin on admission revealed extensive plaque and cauliflower-like warts and large areas of maceration in the anogenital region, the labia and perineum, with large areas of maceration. Nodules were clearly palpable in the left labium majora: the inner aspects were markedly reddened and had some cutaneous erosions. These findings suggested giant condyloma (GC; Buschke-Löwenstein tumour).
  
  
  METHODS
  Biopsy showed marked condylomatous epithelial proliferations which, with the formation of markedly thickened epithelial cones, had reached the stage of a verrucous carcinoma.
  
  
  METHODS
  Under local anti-inflammatory and adstringent medications the inflammatory reaction quickly subsided. Vulvectomy was performed to remove the tumour.
  
  
  CONCLUSIONS
  Giant condyloma (Buschke-Löwenstein tumour) is a rare pseudocancereous lesion. If human papilloma viruses of type 16 or 18 is demonstrated in the lesions, malignant degeneration should be considered. Histological examination is essential to differentiate it from squamous cell carcinoma.
authors.affiliation: Klinik für Hautkrankheiten, Friedrich-Schiller-Universität Jena.
authors.forename: C
authors.initials: C
authors.lastname: Greif
authors.forename: A
authors.initials: A
authors.lastname: Bauer
authors.forename: W
authors.initials: W
authors.lastname: Wigger-Alberti
authors.forename: P
authors.initials: P
authors.lastname: Elsner
mesh_terms: D018289:Carcinoma, Verrucous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003218:Condylomata Acuminata / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery