The effect of da-fang-feng-tang on treatment of type II collagen-induced arthritis in DBA/1 mice.
Da-Fang-Feng-Tang (DFFT), which is believed to be effective for treating human rheumatoid arthritis (RA), was given to DBA/1 mice at the onset of type II collagen-induced arthritis (CIA) to examine its effect. Granules of the crude DFFT extract were administered by gastric gavage at a dose of 1.6 g/kg/day for 12 weeks, starting the day CIA began. The levels of anticollagen IgG antibody were significantly decreased in the sera of the DFFT-treated group compared with the control group from weeks 2 to 7 after the onset of CIA. The severity of arthritis in the DFFT-treated group was markedly alleviated when compared with the control group. In addition, histological examination of the DFFT-treated group showed less cartilage and bone erosion. These results suggest that administration of DFFT suppressed the development of CIA in mice and support the belief that DFFT is effective in treating human RA.
Wang
L R
LR
Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
Ishiguro
N
N
Yamada
E
E
Nishida
Y
Y
Sato
K
K
Iwata
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D007074:Immunoglobulin G; C400344:da-fang-feng-tang; D003094:Collagen