title: Acquired protein C deficiency following cisplatinum-navelbine administration for locally advanced breast cancer. Case report.
abstract: Thromboembolic events have recently been reported following diverse regimens of chemotherapy for breast cancer. This is a report of a 39-year-old woman, a diagnosed case of locally advanced breast cancer, who received many regimens of chemotherapy. She presented with deep venous thrombosis 2 months after starting the cisplatinum-navelbine regimen. Protein C deficiency was the only abnormal coagulation test that normalized after cessation of chemotherapy.
authors.affiliation: Department of Internal Medicine, American University of Beirut, Medical Center, Lebanon.
authors.forename: A
authors.initials: A
authors.lastname: Taher
authors.forename: A
authors.initials: A
authors.lastname: Shamsseddine
authors.forename: N
authors.initials: N
authors.lastname: Saghir
authors.forename: M
authors.initials: M
authors.lastname: Seoud
authors.forename: F
authors.initials: F
authors.lastname: Mourad
authors.forename: B
authors.initials: B
authors.lastname: Dabajah
authors.forename: A
authors.initials: A
authors.lastname: Khalil
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D006801:Humans; D020151:Protein C Deficiency / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000209:etiology; D014747:Vinblastine / Q000009:adverse effects / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D002945:Cisplatin; D000077235:Vinorelbine