Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives.
Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.
Kvasyuk
E I
EI
Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, Belarus.
Mikhailopulo
I A
IA
Suhadolnik
R J
RJ
Henderson
E E
EE
Muto
N F
NF
Iacono
K T
KT
Homon
J
J
Pfleiderer
W
W
D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001704:Biopolymers; D016048:Dideoxyadenosine / Q000737:chemistry*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000494:pharmacology; D016133:Polymerase Chain Reaction; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000227:Adenine Nucleotides; D019380:Anti-HIV Agents; D001704:Biopolymers; D009843:Oligoribonucleotides; D018894:Reverse Transcriptase Inhibitors; D016048:Dideoxyadenosine; C023505:2',5'-oligoadenylate; D054303:HIV Reverse Transcriptase