title: Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease.
abstract: In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE epsilon4 alleles were significantly increased in AD vs. N (chi2 = 33.3, P < 0.000001). However, neither the -491 A/T (chi2 = 1.13, P = 0.29) nor A2M (chi2 = 0.18, P = 0.67) polymorphism was associated with AD risk, suggesting that these polymorphisms do not represent risk factors for AD in the Chinese population.
authors.affiliation: Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Baum
authors.forename: H K
authors.initials: HK
authors.lastname: Ng
authors.forename: L Y
authors.initials: LY
authors.lastname: Chan
authors.forename: I
authors.initials: I
authors.lastname: Sastre
authors.forename: M J
authors.initials: MJ
authors.lastname: Artíga
authors.forename: F
authors.initials: F
authors.lastname: Valdivieso
authors.forename: M J
authors.initials: MJ
authors.lastname: Bullido
authors.forename: H F
authors.initials: HF
authors.lastname: Chiu
authors.forename: C P
authors.initials: CP
authors.lastname: Pang
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005091:Exons; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006723:Hong Kong; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012016:Reference Values; D017384:Sequence Deletion; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000511:alpha-Macroglobulins