title: Total hepatectomy and liver transplantation for metastatic neuroendocrine tumors of the pancreas - a single center experience with ten patients.
abstract: BACKGROUND
  Metastatic neuroendocrine pancreatic tumors have a poor prognosis. We have studied retrospectively the efficacy of liver transplantation as ultimate therapy of otherwise untreatable symptomatic neuroendocrine hepatic metastases originating in the pancreas.
  
  
  METHODS
  We reviewed our experience of liver transplantation (LTx) for hepatic metastases of neuroendocrine pancreatic tumors in ten patients. The indication for liver grafting was seen in cases of irresectable metastases and when patients were suffering from otherwise untreatable tumor-associated symptoms due to massive hormonal release or large intra-abdominal tumor bulk.
  
  
  RESULTS
  In four patients, the primary tumors had been removed before LTx, in five patients simultaneously with LTx and in one case 46 months after grafting. There was no operative mortality. After hepatectomy and LTx, all patients had complete relief of symptoms and all preoperatively increased hormonal levels returned to normal. In nine of ten patients, the transplant procedure had the potential for cure, whereas, in one patient, the primary tumor had remained in situ at LTx and was removed 46 months later by an R2-resection. At present, nine patients are alive with a median follow-up of 33 months (range 13.5 months to 117 months). The one patient in whom the primary tumor was removed after transplantation died due to massive intra-abdominal tumor spread 68 months after LTx. Currently, two patients are without evidence of disease, but one of them after re-operation because of lymph-node metastases 8 months after transplantation. The longest disease-free survival is now more than 7 years. In seven of nine patients, tumor recurred between 1.5 months and 48 months after transplantation.
  
  
  CONCLUSIONS
  Patients with otherwise untreatable symptomatic neuroendocrine hepatic metastases of pancreatic origin may benefit from total hepatectomy and liver transplantation with regard to symptomatic relief and long-term survival, despite frequent recurrence of disease. In some patients, liver transplantation may even offer the chance for cure.
authors.affiliation: Klinik und Poliklinik für Allgemein- und Transplantationschirurgie, Universitätsklinikum Essen, Hufelandstr. 55, D-45122 Essen, Germany,
authors.forename: H
authors.initials: H
authors.lastname: Lang
authors.forename: H J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Flemming
authors.forename: B
authors.initials: B
authors.lastname: Nashan
authors.forename: G F
authors.initials: GF
authors.lastname: Scheumann
authors.forename: K J
authors.initials: KJ
authors.lastname: Oldhafer
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
authors.forename: R
authors.initials: R
authors.lastname: Raab
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011379:Prognosis; D013997:Time Factors