title: Synthesis and biophysical studies of modified oligonucleotides containing acyclic amino alcohol nucleoside analogs.
abstract: Novel serine derivative of thymine was prepared and incorporated into oligonucleotides. These modified oligonucleotides were studied for their binding affinity with complementary DNA/RNA.
authors.affiliation: Research Division, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Ramasamy
authors.forename: V
authors.initials: V
authors.lastname: Stoisavljevic
mesh_terms: D004247:DNA / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry*; D043264:Phosphodiesterase I; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D012313:RNA / Q000737:chemistry
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009841:Oligonucleotides; D012313:RNA; D004247:DNA; D010727:Phosphoric Diester Hydrolases; D043264:Phosphodiesterase I