title: Neuroprotective effects of early vs. late administration of dantrolene in experimental status epilepticus.
abstract: We examined the effects of dantrolene, an inhibitor of intracellular calcium release, on hippocampal neuronal damage associated with 140 min of limbic status epilepticus in the rat. Dantrolene (10 mg/kg i.p.) was administered after either 30 min or 140 min of status epilepticus. Early administration was associated with a significant reduction in the amount of neuronal injury in all hippocampal subregions, while late administration was associated with less neuronal injury in area CA3 only. These findings suggest that a substantial portion of seizure-induced hippocampal injury is associated with release of calcium from intracellular stores, and that early administration of dantrolene may be a useful adjunct to anticonvulsant treatment of status epilepticus.
authors.affiliation: Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, KY 40292, USA.
authors.forename: M
authors.initials: M
authors.lastname: Niebauer
authors.forename: M
authors.initials: M
authors.lastname: Gruenthal
mesh_terms: D000818:Animals; D016923:Cell Death; D003620:Dantrolene / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D008032:Limbic System / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D018696:Neuroprotective Agents; D003620:Dantrolene