title: Reduced epinephrine-stimulated lipolytic activity in male golden-mantled ground squirrel during hibernation: an in situ microdialysis study.
abstract: We studied lipolytic activities in vivo in golden mantle ground squirrels during pre-hibernation and hibernation using microdialysis technique. Microdialysis probes were inserted into the abdominal subcutaneous adipose tissues. Baseline lipolysis were assessed by measuring glycerol concentration. Epinephrine-stimulated lipolysis was also examined. Eight squirrels (four male, four female) were studied in each of the two stages. Basal glycerol concentrations were lower in the hibernating state than in the pre-hibernation state in male squirrels (P < 0.05). Epinephrine application induced glycerol release in male and female squirrels (P < 0.001) in both stages. Male squirrels demonstrated a reduced epinephrine-stimulated glycerol release in the hibernating state, which was not observed in female squirrels.
authors.affiliation: Center for Human Nutrition, School of Medicine, University of California, Los Angeles, USA.
authors.forename: M
authors.initials: M
authors.lastname: Flechtner-Mors
authors.forename: H H
authors.initials: HH
authors.lastname: Ditschuneit
authors.forename: I
authors.initials: I
authors.lastname: Yip
authors.forename: A
authors.initials: A
authors.lastname: Alt
authors.forename: R M
authors.initials: RM
authors.lastname: Torres-Schow
authors.forename: S
authors.initials: S
authors.lastname: Membrano
authors.forename: R
authors.initials: R
authors.lastname: Caquin
authors.forename: C
authors.initials: C
authors.lastname: Tam
authors.forename: T
authors.initials: T
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: Heber
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D005990:Glycerol / Q000032:analysis; D006605:Hibernation / Q000187:drug effects* / Q000502:physiology; D019344:Lactic Acid / Q000032:analysis; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D017551:Microdialysis; D012589:Sciuridae; D013997:Time Factors
chemical_list: D019344:Lactic Acid; D005990:Glycerol; D004837:Epinephrine