Shaping excitation at glutamatergic synapses.
Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.
Conti
F
F
Istituto di Fisiologia Umana, Università di Ancona, I-60020 Ancona, Italy.
Weinberg
R J
RJ
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000737:chemistry / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology*; D013569:Synapses / Q000737:chemistry* / Q000502:physiology*
D017470:Receptors, Glutamate; D018698:Glutamic Acid