Potential intracellular targets for anabolic/anti-catabolic therapies.
The intracellular signalling pathways controlling muscle protein synthesis and proteolysis are potential targets for anabolic/anti-catabolic therapy. In this review, we consider both the potentiation of the effect of anabolic hormones and suppression of the catabolic action of cytokines. Potential candidates, in particular isoforms of the protein kinase C family, and their role in the control of ribosomal action and the ubiquitin-proteasome proteolytic system are discussed.
Palmer
R M
RM
Rowett Research Institute, Bucksbum, Aberdeen, UK. rmp@rri.sari.ac.uk
Thompson
M G
MG
D000818:Animals; D002100:Cachexia / Q000503:physiopathology* / Q000628:therapy*; D016207:Cytokines / Q000037:antagonists & inhibitors; D004357:Drug Synergism; D006728:Hormones / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology*; D009132:Muscles / Q000378:metabolism
D016207:Cytokines; D006728:Hormones