title: Potential predictors of outcome in patients with tissue loss who undergo infrainguinal vein bypass grafting.
abstract: OBJECTIVE
  Aggressive attempts at limb salvage in patients with ischemic tissue loss are justified by favorable initial results in most patients. The identification of patients whose conditions will not benefit from attempted revascularization remains difficult.
  
  
  METHODS
  This study was designed as a retrospective review of prospectively collected clinical data. The subjects were 210 consecutive patients who underwent infrainguinal vein bypass grafting for ischemic tissue loss in the setting of an academic medical center. Bypass grafting was to the popliteal artery in 56 patients, to the infrapopliteal arteries in 131 patients, and to the pedal arteries in 23 patients. The follow-up examination was complete in 209 of 210 patients. One hundred twenty-five patients underwent blinded review of duplex scan venous mapping and arteriography to determine simplified vein and run-off scores. The outcome measures were the influence of risk factors, venous conduit, and runoff on mortality, limb loss, and graft failure at the 6-month follow-up examination.
  
  
  RESULTS
  One hundred seventy patients (81%) were alive and had limb salvage. Nineteen patients (9.1%) died, with need for a simultaneous inflow procedure and end-stage renal disease being most commonly associated with mortality. Thirty-three patients (15.8%) had undergone amputation: 18 after graft failure, and 15 for progressive tissue loss despite a patent graft. Amputation was significantly more common in patients with diabetes (P =.05) and with poor runoff scores (poor runoff, 44.4% vs good runoff, 7.4%; P <.01). Amputation despite a patent graft also correlated with runoff (poor runoff, 41.7% vs good runoff, 4.3%; P <.01). Twenty-five patients had graft failure without amputation, so that only 145 patients (69.4%) were alive, had limb salvage, and had a patent graft. Run-off score was the strongest predictor of outcome, with 70% of patients with poor run-off scores having death, amputation, or graft failure.
  
  
  CONCLUSIONS
  Aggressive use of infrainguinal vein bypass grafting in patients with ischemic tissue loss results in a high rate of initial limb salvage but significant morbidity and mortality. Arteriographically determined runoff scores appear to potentially identify patients at high risk for a poor initial outcome and may provide a method of selecting patients for primary amputation.
authors.affiliation: Section of Vascular Surgery, Department of Surgery, University of Florida College of Medicine, Naples, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Seeger
authors.forename: H A
authors.initials: HA
authors.lastname: Pretus
authors.forename: L C
authors.initials: LC
authors.lastname: Carlton
authors.forename: T C
authors.initials: TC
authors.lastname: Flynn
authors.forename: C K
authors.initials: CK
authors.lastname: Ozaki
authors.forename: T S
authors.initials: TS
authors.lastname: Huber
mesh_terms: D000671:Amputation, Surgical; D000792:Angiography; D001158:Arteries / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000098:blood supply; D005544:Forecasting; D006085:Graft Survival; D006801:Humans; D007264:Inguinal Canal / Q000098:blood supply; D007511:Ischemia / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000150:complications; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex; D014680:Veins / Q000637:transplantation*