title: Artificial neural networks for computer-aided modelling and optimisation in micellar electrokinetic chromatography.
abstract: The separation process in capillary micellar electrochromatography (MEKC) can be modelled using artificial neural networks (ANNs) and optimisation of MEKC methods can be facilitated by combining ANNs with experimental design. ANNs have shown attractive possibilities for non-linear modelling of response surfaces in MEKC and it was demonstrated that by combining ANN modelling with experimental design, the number of experiments necessary to search and find optimal separation conditions can be reduced significantly. A new general approach for computer-aided optimisation in MEKC has been proposed which, because of its general validity, can also be applied in other separation techniques.
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Havel
authors.forename: M
authors.initials: M
authors.lastname: Breadmore
authors.forename: M
authors.initials: M
authors.lastname: Macka
authors.forename: P R
authors.initials: PR
authors.lastname: Haddad
mesh_terms: D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D003198:Computer Simulation; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D008670:Metals / Q000032:analysis; D016571:Neural Networks, Computer; D012107:Research Design
chemical_list: D008670:Metals; C005390:CDTA; D004492:Edetic Acid