The cytotoxicity of anti-PAI-1 oligonucleotides and their conjugates.
The cytotoxicity of anti-PAI-5 hexadecanucleotides (phosphodiesters and phosphorothioates) and their conjugates with lipophilic alcohols was tested in EA.hy 926 hybrid endothelial cells. Some cytotoxicity was found for cholesteryl and bornyl conjugates at concentrations higher than those used for antisense inhibition experiments.
Kobylańska
A
A
Polish Academy of Sciences, Department of Bioorganic Chemistry, Lódź, Poland.
Pluskota
E
E
Pawłowska
Z
Z
Okruszek
A
A
Cierniewski
C S
CS
Stec
W J
WJ
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry / Q000494:pharmacology*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*
D009841:Oligonucleotides; D017395:Plasminogen Activator Inhibitor 1