title: The GPIa C807T dimorphism associated with platelet collagen receptor density is not a risk factor for myocardial infarction.
abstract: The platelet collagen receptor, GPIa/IIa, is an important mediator of platelet adhesion to fibrillar collagens at sites of vascular injury. Recently, a dimorphism at nucleotide 807 of the GPIa cDNA (TTC/TTT in codon 224) was shown to be associated with variation in GPIa/IIa receptor density on the platelet surface. We conducted a case-control study to determine if the 807T allele, linked with increased GPIa/IIa density, contributed to risk of myocardial infarction (MI). DNA from 546 acute MI cases and 507 controls, all aged <75 years, was genotyped for the C807T dimorphism using the TaqManTM system of allelic discrimination. The allelic odds ratio (OR) for MI in the complete cohort was 0.88 (95% CI 0.74-1.05, P = 0.17), indicating that the 807T allele was not associated with an increased risk of MI. There was also no increased risk of MI associated with the homozygous 807TT (P = 0.22) or heterozygous 807CT (P = 0.24) genotypes or for carriers of the 807T allele in any cohort subgroup analysed. We conclude that the GPIa 807T allele is not a risk factor for MI in our population either alone or in combination with other major cardiovascular risk factors.
authors.affiliation: Division of Molecular and Genetic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield. s.a.croft@sheffield.ac.uk
authors.forename: S A
authors.initials: SA
authors.lastname: Croft
authors.forename: K K
authors.initials: KK
authors.lastname: Hampton
authors.forename: J A
authors.initials: JA
authors.lastname: Sorrell
authors.forename: R P
authors.initials: RP
authors.lastname: Steeds
authors.forename: K S
authors.initials: KS
authors.lastname: Channer
authors.forename: N J
authors.initials: NJ
authors.lastname: Samani
authors.forename: M E
authors.initials: ME
authors.lastname: Daly
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D006801:Humans; D016023:Integrins / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism; D038981:Receptors, Collagen; D012307:Risk Factors
chemical_list: D016023:Integrins; D038981:Receptors, Collagen