Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds.
Efficient syntheses of ent-isozonarol (6a), ent-isozonarone (7a) and ent-chromazonarol (8) from (-)-sclareol (12) are described. 6a and 7a show a significative antitumoral activity.
Barrero
A F
AF
Instituto de Biotecnologia, Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Granada, Spain. afbarre@goliat.ugr.es
Alvarez-Manzaneda
E J
EJ
Herrador
M M
MM
Chahboun
R
R
Galera
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014966:Xanthenes; C121655:chromazonarol