title: [Heterogeneity of chloroquine resistant malaria in Senegal].
abstract: In order to evaluate the in vivo efficacy of chloroquine in the treatment of P. falciparum malaria, studies have been carried out in Richard-Toll, Fatick and Tambacounda, 3 areas where dynamics of transmission, population movements, as well as prophylactic and curative practises are different. Failure rates in treatment were 13% in site 1 (Richard-Toll) where medical pressure and population movements are high. In sites 2 and 3 (Fatick and Tambacounda), the failure rate was 3%. Even if medical pressure is lower in the latter site (Tambacounda), the higher transmission could be a factor in the spreading of resistance. A surveillance system and better use of chloroquine must be undertaken.
authors.affiliation: Service de parasitologie, Faculté de médecine, UCAD, Dakar, Sénégal. ogaye@ucad.refer.sn
authors.forename: O
authors.initials: O
authors.lastname: Gaye
authors.forename: M
authors.initials: M
authors.lastname: Soumaré
authors.forename: B
authors.initials: B
authors.lastname: Sambou
authors.forename: O
authors.initials: O
authors.lastname: Faye
authors.forename: Y
authors.initials: Y
authors.lastname: Dieng
authors.forename: M
authors.initials: M
authors.lastname: Diouf
authors.forename: I B
authors.initials: IB
authors.lastname: Bah
authors.forename: T
authors.initials: T
authors.lastname: Dieng
authors.forename: O
authors.initials: O
authors.lastname: N'dir
authors.forename: S
authors.initials: S
authors.lastname: Diallo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000635:transmission; D012675:Senegal; D017211:Treatment Failure
chemical_list: D002738:Chloroquine