title: Hypertension as a paraneoplastic syndrome in hepatocellular carcinoma.
abstract: We report a 66-year-old man with hepatocellular carcinoma who was positive for hepatitis B surface antigen, and was hospitalized because of hypoglycemia and hypertension. His plasma renin activity was normal (2.3 ng/ml per h), but concentrations of angiotensin I (>2500 pg/ml) and II (86 pg/ml) were high. Increased angiotensin I level at sites proximal and distal from the confluence of the hepatic vein and the inferior vena cava indicated that the hypertension was provoked by overproduction of angiotensin I from the hepatocellular carcinoma. Previous reports of patients with hepatocellular carcinoma with hypertension due to abnormality of renin-angiotensin system are reviewed.
authors.affiliation: Department of Internal Medicine, National Sanatorium Nishi-Gunma Hospital, Shibukawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: F
authors.initials: F
authors.lastname: Makita
authors.forename: S
authors.initials: S
authors.lastname: Mitsugi
authors.forename: K
authors.initials: K
authors.lastname: Yuasa
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000368:Aged; D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D017809:Fatal Outcome; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D007003:Hypoglycemia / Q000175:diagnosis; D008113:Liver Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008297:Male; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000175:diagnosis*; D012083:Renin / Q000097:blood; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D000804:Angiotensin II; D000803:Angiotensin I; D012083:Renin