title: First trimester sonographic diagnosis of holoprosencephaly.
abstract: OBJECTIVE
  To describe our experience with sonographic diagnosis of fetal holoprosencephaly in first trimester.
  
  
  METHODS
  A total of three fetuses with early prenatal diagnosis of holoprosencephaly were sonographically evaluated and followed up.
  
  
  RESULTS
  The study revealed that all showed monoventricular cavity, fused thalami, no falx and cavum septum pellucidum. All of them were correctly diagnosed sonographically in the first trimester. Extracranial anomalies had also been identified in all three fetuses and all of them had facial abnormalities. Cytogenetic studies were successfully carried out in only one case. No polyhydramnios was demonstrated in all cases.
  
  
  CONCLUSIONS
  This small series indicates that holoprosencephaly can be diagnosed in the first trimester. The most valuable clue to the diagnosis is the demonstration of the single ventricle.
authors.affiliation: Department of Obstetrics and Gynecology, Chiang Mai University, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Tongsong
authors.forename: C
authors.initials: C
authors.lastname: Wanapirak
authors.forename: P
authors.initials: P
authors.lastname: Chanprapaph
authors.forename: S
authors.initials: S
authors.lastname: Siriangkul
mesh_terms: D000328:Adult; D005260:Female; D016142:Holoprosencephaly / Q000000981:diagnostic imaging*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal