P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I.
A series of potent P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I is described.
Chatterjee
S
S
Cephalon Inc., West Chester, PA 19380-4245, USA.
Dunn
D
D
Tao
M
M
Wells
G
G
Gu
Z Q
ZQ
Bihovsky
R
R
Ator
M A
MA
Siman
R
R
Mallamo
J P
JP
D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D002154:Calpain / Q000037:antagonists & inhibitors*; D006801:Humans; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
D000577:Amides; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D002154:Calpain