Syndrome of inappropriate secretion of antidiuretic hormone in malignancy.
OBJECTIVE
To provide a review of pathophysiology, epidemiology, signs and symptoms, diagnosis, treatment, and nursing management of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignancy.


METHODS
Research reports, review articles, and book chapters relevant to SIADH.


CONCLUSIONS
The principle cause of hyponatremia in malignancy is SIADH. Early recognition and prompt treatment can prevent serious neurologic sequelae. Antineoplastic therapy and methods to correct hyponatremia constitute effective treatment strategies.


CONCLUSIONS
Nurses play a major role in nursing assessment, appropriate interventions and symptom control, and promoting resolution of problems and optimal quality of life in patients with malignancy complicated by SIADH.
Keenan
A M
AM
Rush-Presbyterian-St Luke's Medical Center, Chicago, IL, USA.
D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology / Q000451:nursing*; D008175:Lung Neoplasms / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009859:Oncology Nursing