title: Prevention of postoperative air leakage from lungs using a purified human collagen membrane-polyglycolic acid sheet.
abstract: BACKGROUND
  Human amnion has useful biomedical applications because it contains a large amount of human collagen fibers. We prepared purified human collagen membrane (HCM) from human amnion and used it to develop a new sheet by combining it with synthetic bioabsorbable polyglycolic acid (PGA) mesh. We evaluated its efficacy in preventing air leakage from the lungs of dogs.
  
  
  METHODS
  In 20 dogs, HCM-PGA sheet (n = 5), sheets using fibrin glue with a separate application method (n = 5), a mixed application method (n = 5), and fibrin glue alone (n = 5), were used as dressing materials after partial lung resection.
  
  
  RESULTS
  The HCM-PGA sheet using fibrin glue with a separate application method was shown to be significantly more effective by an air leakage pressure test than the other three methods. These results indicate that the HCM-PGA sheet is useful for preventing air leakage from the lung.
  
  
  CONCLUSIONS
  The HCM-PGA sheet is more effective than conventional fibrin glue for controlling postoperative air leakage.
authors.affiliation: Department of Artificial Organs, Research Center for Biomedical Engineering, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: M
authors.initials: M
authors.lastname: Teramachi
authors.forename: T
authors.initials: T
authors.lastname: Kiyotani
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000650:Amnion; D000818:Animals; D001684:Biological Dressings; D002823:Chorion; D003094:Collagen; D004285:Dogs; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology / Q000517:prevention & control*; D011013:Pneumonectomy; D011027:Pneumoperitoneum / Q000473:pathology / Q000517:prevention & control*; D011100:Polyglycolic Acid; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D016156:Respiratory Tract Fistula / Q000473:pathology / Q000517:prevention & control*; D013526:Surgical Mesh
chemical_list: D015718:Fibrin Tissue Adhesive; D011100:Polyglycolic Acid; D003094:Collagen