Hepatoprotective activity of leaves of Cassia occidentalis against paracetamol and ethyl alcohol intoxication in rats.
Cassia occidentalis L. (Caesalpiniaceae), commonly known as 'Kasondi', is used in Unani medicine for liver ailments and is an important ingredient of several polyherbal formulations marketed for liver diseases. The hepatoprotective effect of aqueous-ethanolic extract (50%, v/v) of leaves of kasondi was studied on rat liver damage induced by paracetamol and ethyl alcohol by monitoring serum transaminase (aspartate amino transferase and serum alanine amino transferase), alkaline posphatase, serum cholesterol, serum total lipids and histopathological alterations. The extract of leaves of the plant produced significant hepatoprotection.
Jafri
M A
MA
Department of Ilmul Advia, Faculty of Medicine(Unani), Jamia Hamdard, New Delhi, India.
Jalis Subhani
M
M
Javed
K
K
Singh
S
S
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001522:Behavior, Animal / Q000187:drug effects; D002366:Cassia / Q000737:chemistry*; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000097:blood; D004347:Drug Interactions; D000431:Ethanol / Q000633:toxicity*; D007194:India; D008055:Lipids / Q000097:blood; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008111:Liver Function Tests / Q000379:methods; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate
D008055:Lipids; D010936:Plant Extracts; D000082:Acetaminophen; D000431:Ethanol; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase