title: Conventional respiratory viruses recovered from immunocompromised patients: clinical considerations.
abstract: Lower respiratory tract infection is the most common complication in the immunocompromised patient. From January 1991 to December 1995, 785 consecutive patients with suspected respiratory tract infections were studied. One hundred ninety-nine viruses were isolated from 182 (23%) of 785 bronchoalveolar lavage fluid specimens. Cytomegalovirus was isolated from 131 patients, herpes simplex virus was recovered from 31, and conventional respiratory viruses (CRVs) were recovered from 36. There were 9 influenza A viruses, 2 influenza B viruses, 7 parainfluenza viruses, 5 respiratory syncytial viruses, 5 adenoviruses, 6 enteroviruses, and 3 rhinoviruses. We identified 22 patients from whom a CRV was the only microorganism recovered; 13 patients developed pneumonia, 10 had acute respiratory failure, 5 required support with mechanical ventilation, and 5 (23%) died. In conclusion, CRVs are frequent causes of respiratory illnesses and are associated with high rates of morbidity and mortality among immunocompromised patients.
authors.affiliation: Servei de Microbiologia, Unitat de Malalties Infeccioses, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain. mic@santpau.es
authors.forename: N
authors.initials: N
authors.lastname: Rabella
authors.forename: P
authors.initials: P
authors.lastname: Rodriguez
authors.forename: R
authors.initials: R
authors.lastname: Labeaga
authors.forename: M
authors.initials: M
authors.lastname: Otegui
authors.forename: M
authors.initials: M
authors.lastname: Mercader
authors.forename: M
authors.initials: M
authors.lastname: Gurguí
authors.forename: G
authors.initials: G
authors.lastname: Prats
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification; D003587:Cytomegalovirus / Q000302:isolation & purification; D004770:Enterovirus / Q000302:isolation & purification; D006564:Herpesviridae / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D009975:Orthomyxoviridae / Q000302:isolation & purification; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000150:complications / Q000401:mortality / Q000821:virology*; D012229:Rhinovirus / Q000302:isolation & purification; D012307:Risk Factors