Unravelling the kinetoplastid paraflagellar rod.
Researchers who study human pathogens are often interested in unique and essential aspects of the biology of the pathogen. Recent progress has been made in understanding such a target in kinetoplastid parasites. The paraflagellar rod is a unique cytoskeletal structure that plays a key role in the life-cycle of these fascinating organisms. This review discusses the protein components and structure of the paraflagellar rod and its function in cell motility.
Maga
J A
JA
Dept of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
LeBowitz
J H
JH
D000818:Animals; D005407:Flagella / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D007891:Leishmania / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure; D009068:Movement; D011506:Proteins; D015800:Protozoan Proteins / Q000502:physiology*; D014345:Trypanosoma / Q000472:pathogenicity / Q000502:physiology*
D011506:Proteins; D015800:Protozoan Proteins; C064816:kinetoplast-associated protein, protozoan