title: Blood-brain barrier and blood volume imaging of cerebral glioma using functional CT: a pictorial review.
abstract: We present five cases of cerebral glioma that illustrate the benefit of functional CT imaging of blood-brain barrier permeability and cerebral blood volume. Functional CT uses Patlak analysis of a single location dynamic sequence to extract physiological information that is useful clinically in the assessment of cerebral gliomas. Functional CT offers distinct advantages over other functional modalities, including clearer delineation of tumour, tumour grading, measurement of tumour activity and monitoring response to therapy.
authors.affiliation: Centre for Functional Imaging, Southern X-ray Clinics and the Wesley Research Institute, Wesley Hospital, Auchenflower, Brisbane, Australia.
authors.forename: D A
authors.initials: DA
authors.lastname: Leggett
authors.forename: K A
authors.initials: KA
authors.lastname: Miles
authors.forename: B B
authors.initials: BB
authors.lastname: Kelley
mesh_terms: D000368:Aged; D001810:Blood Volume; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed / Q000379:methods