Bombesin injection into the central amygdala influences feeding behavior in the rat.
The present study was performed to determine whether low doses (10 or 40 ng) of bombesin microinjected into the amygdala could modify solid food intake. Forty ng of bombesin in 24 h deprived rats caused transient inhibition of food intake. This inhibitory effect was eliminated by prior bombesin antagonist treatment. A series of quantitative behavioral tests indicated that low doses of bombesin application specifically reduced food intake without altering the behavioral pattern or influencing the body temperature. The present results suggest, that bombesin-like peptides may act as a satiety signal in the central part of the amygdala.
Vígh
J
J
Department of Zoology and Neurobiology, Faculty of Natural Sciences, Janus Pannonius University, Pécs, Hungary.
Lénárd
L
L
Fekete
E
E
Hernádi
I
I
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001839:Bombesin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005508:Food Deprivation; D008297:Male; D051381:Rats
C051814:bombesin, Phe(12), Leu(14)-; D001839:Bombesin