title: Signet-ring cell variant of small lymphocytic lymphoma with a prominent sinusoidal pattern.
abstract: Signet-ring cell lymphoma is a rare morphologic variant of non-Hodgkin's lymphoma characterized by neoplastic lymphoid cells with cytoplasmic vacuoles or eosinophilic globules that impart a signet-ring cell morphology. Although most cases are variants of follicular center B-cell lymphomas, this pattern also can be seen in T-cell lymphomas. An indolent clinical course and prolonged survival have characterized the majority of published cases. We document the case of a 62-year-old African-American woman with diffuse small lymphocytic signet-ring lymphoma having a predominant sinusoidal growth pattern, which, to our knowledge, has not been previously reported. The prominent sinusoidal pattern of signet-ring lymphocytes contributes to its confusion with metastatic signet-ring cell adenocarcinoma. The correct diagnosis is greatly facilitated by the use of appropriate immunohistochemical stains for lymphoid markers.
authors.affiliation: Division of Anatomic Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: D
authors.initials: D
authors.lastname: Ramnani
authors.forename: G
authors.initials: G
authors.lastname: Lindberg
authors.forename: S T
authors.initials: ST
authors.lastname: Gokaslan
authors.forename: J
authors.initials: J
authors.lastname: Albores-Saavedra
mesh_terms: D001365:Axilla / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D018279:Carcinoma, Signet Ring Cell / Q000737:chemistry / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000737:chemistry / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000737:chemistry / Q000648:ultrastructure; D008875:Middle Aged; D014617:Vacuoles / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor