Determinants of pathogenicity of echovirus 9 in men: significance of a functional RGD-motif.
In this study, we investigated nine independent echovirus 9 isolates obtained from sick children in 1995. It is discovered that these isolates differ in respect to their pathogenicity for newborn mice indicating that the degree of human pathogenicity of an echovirus 9 variant does not necessarily correlate with mouse pathogenicity. Nevertheless, all virus variants are found to code for an RGD-motif within their VP1 protein. Hence, the RGD-motif and its highly conserved flanking regions are the conditio sine qua non, but, as expected, not sufficient for the mouse-pathogenic character.
Nelsen-Salz
B
B
Institut für Virologie der Universität zu Köln, Germany. birgit.nelsen-salz@medizin.uni-koeln.de
Schildgen
O
O
Klein
M
M
Hadaschik
D
D
Eggers
H J
HJ
Zimmermann
H
H
D000595:Amino Acid Sequence; D000818:Animals; D002213:Capsid / Q000737:chemistry*; D036022:Capsid Proteins; D002648:Child; D002675:Child, Preschool; D004459:Echovirus 9 / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000502:physiology*
D036022:Capsid Proteins; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid