title: Preparation of alginate gel beads containing chitosan nicotinic acid salt and the functions.
abstract: Calcium-induced alginate gel beads containing chitosan salt (Alg-CS) was prepared using nicotinic acid (NA), a drug for hyperlipidemia, and investigated its two functions in gastrointestinal tract, (a) NA release from Alg-CS, (b) uptake of bile acids into Alg-CS. The amount of NA incorporated in Alg-CS increased according to increment of CS content. NA was rapidly released from Alg-CS in diluted HCl solution (pH 1.2) or physiological saline without disintegration of the beads. When Alg-CS was placed in bile acid solution it took bile acid into itself. About 80% of taurocholic acid dissolved in the medium was taken into Alg-CS. According to increment of bile acid concentration, the uptake amount increased and an approximately linear relationship existed among them.
authors.affiliation: Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: S
authors.initials: S
authors.lastname: Toniwa
authors.forename: E
authors.initials: E
authors.lastname: Miyamoto
authors.forename: S
authors.initials: S
authors.lastname: Kawashima
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000737:chemistry*; D008863:Microspheres; D009525:Niacin / Q000008:administration & dosage / Q000737:chemistry*; D012995:Solubility
chemical_list: D000464:Alginates; D001647:Bile Acids and Salts; D000960:Hypolipidemic Agents; D002686:Chitin; D009525:Niacin; D048271:Chitosan; D002118:Calcium