title: Preoperative pulse wave velocity fails to predict hemodynamic responses to anesthesia and to surgical stimulation.
abstract: OBJECTIVE
  To determine whether pulse wave velocity (PWV), which is a useful indicator of cardiovascular disease, can predict the hemodynamic responses to anesthesia and surgical stimulation in surgical patients.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  Operating rooms at a university hospital.
  
  
  METHODS
  30 ASA physical status I and II female patients presenting for elective gynecologic surgery.
  
  
  METHODS
  Patients who received one of the following anesthesia techniques were studied; isoflurane, sevoflurane and sevoflurane with nitrous oxide (N2O).
  
  
  RESULTS
  Patients underwent preoperative PWV measurements using an automatic PWV measurement device. Systolic blood pressure and heart rate levels were recorded at baseline, during anesthesia, and at skin incision. PWV had no significant correlation with percent changes of systolic blood pressure or heart rate, even after controlling the choice of anesthetic drugs.
  
  
  CONCLUSIONS
  Preoperative PWV fails to predict hemodynamic responses to anesthesia and to surgical stimulation.
authors.affiliation: Department of Anesthesia, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan. ynakata@med.teikyo-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nakata
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Ishiguro
authors.forename: K
authors.initials: K
authors.lastname: Terui
authors.forename: Y
authors.initials: Y
authors.lastname: Niimi
authors.forename: S
authors.initials: S
authors.lastname: Morita
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology; D017558:Elective Surgical Procedures; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D005544:Forecasting; D013509:Gynecologic Surgical Procedures; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage; D011300:Preoperative Care; D011446:Prospective Studies; D011674:Pulse; D012044:Regression Analysis; D000077149:Sevoflurane; D014160:Transducers, Pressure
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D009609:Nitrous Oxide