title: Glutathione S-transferase alpha levels in epileptic and healthy women preconceptionally and throughout pregnancy.
abstract: We studied plasma GSTA1-1 concentrations in preconceptionally recruited epileptic women who received antiepileptic drugs (n = 99) and a control group of healthy women (n = 106). Mean plasma GSTA1-1 concentrations in the control group did not show significant changes preconceptionally and throughout pregnancy. Six weeks postpartum, however, a significant increase in the mean plasma GSTA1-1 concentration (p < 0.001) was found as compared to preconceptional levels and levels during pregnancy. The mean plasma GSTA1-1 concentration in epileptic women was significantly higher in the 4th gestational week compared to those determined in healthy pregnant women (1.68 versus 1.08 microg/l, p < 0.001). Values between the groups in the second and third trimester and postpartum period showed no significant differences.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital Nijmegen, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Zusterzeel
authors.forename: M F
authors.initials: MF
authors.lastname: Knapen
authors.forename: E M
authors.initials: EM
authors.lastname: Roes
authors.forename: R P
authors.initials: RP
authors.lastname: Steegers-Theunissen
authors.forename: W H
authors.initials: WH
authors.lastname: Peters
authors.forename: H M
authors.initials: HM
authors.lastname: Merkus
authors.forename: E A
authors.initials: EA
authors.lastname: Steegers
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000473:pathology; D004827:Epilepsy / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology*
chemical_list: D000927:Anticonvulsants; D005982:Glutathione Transferase