Homo- and nor-plakotenin, new carboxylic acids from the Palauan sponge Plakortis lita.
A specimen of Plakortis lita from Palau yielded the new carboxylic acids, homo-plakotenin (2a), the sodium salt of homo-plakotenin (2b), the sodium salt of nor-plakotenin (3), the sodium salt of plakotenin (1b), and the known compound plakotenin (1a). The structures of the new acids were elucidated by interpretation of spectral data and by comparison with the known compound. Compounds 1a, 1b, and 2a were found to significantly reduce proliferation of rheumatoid synovial fibroblasts.
Qureshi
A
A
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
Stevenson
C S
CS
Albert
C L
CL
Jacobs
R S
RS
Faulkner
D J
DJ
D000818:Animals; D018501:Antirheumatic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005347:Fibroblasts; D006801:Humans; D019029:Palau; D011161:Porifera / Q000737:chemistry*; D012216:Rheumatic Diseases / Q000473:pathology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013936:Thymidine / Q000378:metabolism
D018501:Antirheumatic Agents; D002264:Carboxylic Acids; C400358:plakotenin; D013936:Thymidine