title: [Fetal and neonatal mortality from 22 weeks of amenorrhea in the Loire area].
abstract: BACKGROUND
  The Pays de Loire has a low perinatal mortality indicators among French regions but this could be due to under-notification.
  
  
  OBJECTIVE
  To explore this hypothesis we undertook a survey in order to identify all fetal and neonatal deaths occurring at a gestionnal age of 22 weeks or more. We also tried to examine and analyze the causes of death.
  
  
  METHODS
  All maternity (26) and neonatal wards (5) in the region took part in the survey in 1995. Clinicians were asked to fill out a questionnaire for all deaths occurring from gestational age (GA) 22 weeks and/or concerning a birthweight of a least 500 g. Only perinatal deaths related to parents living in the Pays de Loire were included in the study.
  
  
  RESULTS
  Two hundred and sixty seven perinatal deaths were identified out of a total 29,440 births (9.1 /1000). Eighty three (2.8 /1000) were termination of pregnancy for medical reasons, of which 82% were motivated by chromosomic illness. Ninety-nine stillbirths fell (3.4 /1000) into two GA periods: 24 to 27 weeks (20%) and 38 to 41 weeks (2%). The cause of stillbirths remained unknown in 50% of cases despite a post-mortem examination rate of 87%. There were 29 deaths (1 /1000) in the immediate per and post-partum, 40% of which occurred at GA 22 to 25 weeks. Another 38% occurred at GA 36 to 40 weeks and these were related to undectected malformations or infections. Neonatal and intensive care units reported 56 neonatal deaths (1.9 /1000). GA was under 33 weeks for 44% of them. Deaths were caused by usual complications of severe prematurity, neurologic diseases and malformations. Thirty-two percent of total deaths were not notified to the French Authority: 25% of deaths for termination of pregnancy for medical reasons and 7% for stillbirths and per and post partum deaths.
  
  
  CONCLUSIONS
  This survey suggests that the Pays de Loire perinatal mortality indicators remained low compared with other French regions, even after adjustment for this under notification. This casts doubts on the validity of perinatal mortality monitoring based on official notifications. The cause may lie in the inadequacy of legislation of the particular circumstances of perinatal deaths.
authors.affiliation: Service d'Epidémiologie, CHU Rennes.
authors.forename: B
authors.initials: B
authors.lastname: Branger
authors.forename: F
authors.initials: F
authors.lastname: Beringue
authors.forename: M F
authors.initials: MF
authors.lastname: Nomballais
authors.forename: C
authors.initials: C
authors.lastname: Bouderlique
authors.forename: J P
authors.initials: JP
authors.lastname: Brossier
authors.forename: C
authors.initials: C
authors.lastname: Savagner
authors.forename: G
authors.initials: G
authors.lastname: Seguin
authors.forename: G
authors.initials: G
authors.lastname: Boog
authors.forename: J C
authors.initials: JC
authors.lastname: Rozé
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data; D015982:Bias; D002423:Cause of Death; D005260:Female; D005313:Fetal Death / Q000453:epidemiology* / Q000209:etiology; D005602:France / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D011159:Population Surveillance / Q000379:methods; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires