Tumor angiogenesis in patients with laryngeal cancer.
Tumor angiogenesis was evaluated in 60 patients with primary laryngeal cancer by quantitating the microvessel density with antibodies against factor VIII. The microvessel density was then correlated with T stage, N stage, histologic grade and patient survival. A direct correlation was found between increased tumor angiogenesis and T stage, histologic grade and a shorter survival rate.
Kupisz
K
K
Department of Otolaryngology, University Medical School of Lublin, Poland.
Chibowski
D
D
Klatka
J
J
Klonowski
S
S
Stepulak
A
A
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000473:pathology; D007825:Laryngectomy; D007830:Larynx / Q000098:blood supply / Q000473:pathology; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate