Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1.
We report on a male Japanese patient with hairy cell leukemia (HCL). A cytogenetic study with lipopolysaccharide stimuli showed a novel translocation (11;20)(q13;q11) in 10% of the analyzed cells. Northern blot analysis and RT-PCR analysis for cyclin D1 revealed the overexpression of cyclin D1, although the southern blot analysis of PRAD1 gene showed no rearrangement. In this particular case, the t(11;20)(q13;q11) might play some role in the oncogenesis of HCL and the overexpression of cyclin D1.
Ishida
F
F
Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. fumishi@hsp.md.shinshu-u.ac.jp
Kitano
K
K
Ichikawa
N
N
Ito
T
T
Kohara
Y
Y
Taniguchi
T
T
Motokura
T
T
Kiyosawa
K
K
D002880:Chromosomes, Human, Pair 11; D002890:Chromosomes, Human, Pair 20; D019938:Cyclin D1 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007943:Leukemia, Hairy Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D019938:Cyclin D1