title: A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner.
abstract: We have assessed the possibility of artefacts that can arise in attempting to perform simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) using a small prototype MR compatible PET scanner (McPET). In these experiments, we examine MR images for any major artefacts or loss in image quality due to inhomogeneities in the magnetic field, radiofrequency interference or susceptibility effects caused by operation of the PET system inside the MR scanner. In addition, possible artefacts in the PET images caused by the static and time-varying magnetic fields or radiofrequency interference from the MR system were investigated. Biological tissue and a T2-weighted spin echo sequence were used to examine susceptibility artefacts due to components of the McPET scanner (scintillator, optical fibres) situated in the MR field of view. A range of commonly used MR pulse sequences was studied while acquiring PET data to look for possible artefacts in either the PET or MR images. Other than a small loss in signal-to-noise using gradient echo sequences, there was no significant interaction between the two imaging systems. Simultaneous PET and MR imaging of simple phantoms was also carried out in different MR systems with field strengths ranging from 0.2 to 4.7 T. The results of these studies demonstrate that it is possible to acquire PET and MR images simultaneously, without any significant artefacts or loss in image quality, using our prototype MR compatible PET scanner.
authors.affiliation: Crump Institute for Biological Imaging and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA. rslates@mednet.ucla.edu
authors.forename: R B
authors.initials: RB
authors.lastname: Slates
authors.forename: K
authors.initials: K
authors.lastname: Farahani
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.forename: P K
authors.initials: PK
authors.lastname: Marsden
authors.forename: J
authors.initials: J
authors.lastname: Taylor
authors.forename: P E
authors.initials: PE
authors.lastname: Summers
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: J
authors.initials: J
authors.lastname: Beech
authors.forename: S R
authors.initials: SR
authors.lastname: Cherry
mesh_terms: D016477:Artifacts; D004574:Electromagnetic Fields; D005638:Fruit; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D019047:Phantoms, Imaging; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*