title: Tumor lysis syndrome.
abstract: OBJECTIVE
  To review the pathophysiology, clinical manifestations, and management of tumor lysis syndrome.
  
  
  METHODS
  Published articles, case reports, and book chapters on tumor lysis syndrome.
  
  
  CONCLUSIONS
  Tumor lysis syndrome is a very serious and sometimes life-threatening complication of cancer treatment. Identification of patients at risk and initiation of preventative interventions are the focus of medical and nursing management. Ongoing monitoring during and following cancer treatment is necessary to promote early response to changes in patient condition and minimize adverse events.
  
  
  CONCLUSIONS
  Early recognition of signs and symptoms and clinical management of tumor lysis syndrome is a challenging responsibility of the oncology nurse.
authors.affiliation: Ohio State University Medical Center, Arthur G. James Hospital & Research Institute, Columbus, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Ezzone
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D009859:Oncology Nursing; D015275:Tumor Lysis Syndrome / Q000209:etiology / Q000451:nursing* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea