[Effect of L-arg and SNP on pulmonary arterial pressure and vascular structural changes of chronically hypoxic rats].
The effects of L-arginine (L-arg) and sodium nitroprusside (SNP) on pulmonary arterial pressure, the percentage of muscularization of intra-acinar vessels and ultrastructural changes of extra pulmonary artery and pulmonary arteriole of chronically hypoxic rats were studied. The results showed that: (1) Both L-arg and SNP decreased mean pulmonary arterial pressure of chronically hypoxic rats significantly. (2) Both L-arg and SNP reduced the percentage of muscularization of intra-acinar vessels of chronically hypoxic rats significantly. (3) Both L-arg and SNP protected pulmonary artery from the damages of endothelium and the changes in smooth muscle cell phenotype by hypoxia. These results suggested that exogenous nitric oxide might play a role in the protection of pulmonary arterial function and structure which alleviate the development of pulmonary hypertension induced by chronic hypoxia.
Lin
H
H
Institute of Basic Medical Sciences, CAMS, Beijing.
Cai
Y
Y
Song
W
W
Zhou
X
X
Gong
Y
Y
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001120:Arginine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004730:Endothelium, Vascular / Q000648:ultrastructure; D006976:Hypertension, Pulmonary / Q000473:pathology*; D000860:Hypoxia / Q000150:complications / Q000473:pathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D009599:Nitroprusside / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000503:physiopathology / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D009599:Nitroprusside; D001120:Arginine