[The effect of medikhronal on the biogenic amine level in the brain structures and blood of animals with alcohol dependence].
Peculiarities of changes in the content of biogenic amines in the brain structures (hypothalamus, midbrain and new cortex) and blood of rats under alcohol intoxication and formation of alcohol dependence were investigated, and the effect of medichronal and its components on the mentioned processes was found out. It has been established that accumulation of acetaldehide plays a considerable role in the mechanism of formation of alcohol dependence. Changes in the level of ethanol (E) and AcA in blood after the arrival of exogenic E to the organism evokes phase dynamics of content of biogenic amines in the blood and brain sections. Medichronal components, binding and inactivating AcA, as well as taking the mutually supplementing effect on synthesis of biogenic amines, promote normalization of the mentioned processes and elimination of alcohol dependence.
Kharchenko
N K
NK
Ukrainian Scientific-Research Institute of Social and Forensic Psychiatry, Ministry of Public Health of Ukraine, Kiev.
D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005561:Formates / Q000627:therapeutic use*; D005947:Glucose / Q000627:therapeutic use*; D005998:Glycine / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013997:Time Factors
D000427:Alcohol Deterrents; D001679:Biogenic Amines; D004338:Drug Combinations; D005561:Formates; C088648:medikhronal; D005947:Glucose; D005998:Glycine