Effect of vitamin E eye drops on naphthalene-induced cataract in rats.
The effect of vitamin E acetate (VEA) eye drops on naphthalene-induced cataract in rats was investigated by Scheimpflug image analysis. The control group was administered only naphthalene (1 g/kg), while the other group was additionally given 1% VEA eye drops into both eyes 5 times a day every day for 9 weeks from the start of naphthalene treatment. During those 9 weeks, the changes of the crystalline lens were documented by an anterior eye segment analysis system (EAS-1000, NIDEK) once a week in mydriasis (Mydrin-P, Santen Pharmaceutical Co., Ltd.). The characteristic density values of the anterior deeper cortex regions were measured. The light scattering intensity of lenses from VEA eye drop-treated animals was significantly lower than that of animals without VEA treatment. This difference was found 1 week, 4 weeks, and from 7 to 9 weeks after the start of naphthalene application. VEA eye drops may have the potential to delay the progression of naphthalene-induced cataract in rats.
Nagata
M
M
Department of Ophthalmology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Kojima
M
M
Sasaki
K
K
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002386:Cataract / Q000517:prevention & control*; D005260:Female; D009281:Naphthalenes / Q000633:toxicity*; D009883:Ophthalmic Solutions; D051381:Rats; D011914:Rats, Inbred BN; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D009281:Naphthalenes; D009883:Ophthalmic Solutions; D014810:Vitamin E; C031721:naphthalene; D024502:alpha-Tocopherol; D024505:Tocopherols