Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
The chloroform extract (active components from the exotic weed Trianthema portulacastrum L. of Aizoaceae, showed remarkable effect in the reduction of DENA-induced rat hepatocarcinogenesis. Hepatocarcinogenesis was induced in male Sprague-Dawley rats by a single intraperitonial injection of diethylnitrosoamine (DENA) at a dose of 200 mg/kg body weight. Chloroform extract of T. portulacastrum at a dose of 100 mg/kg/body wt. to the basal medium/per animal once daily was administered following DENA injection. Morphometric evaluation revealed that the fraction reduced the incidence, numerical preponderance, multiplicity and size distribution of visible pre-neoplastic nodules. Further focal lesions showed a reduction of altered liver cell foci/cm2 and a reduction of average focal area. A decrease in the percentage of liver parenchyma occupied by foci all seem to suggest the anticarcinogenic potential of Trianthema portulacastrum in DENA-induced rat hepatocarcinogenesis.
Bhattacharya
S
S
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Chatterjee
M
M
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000633:toxicity*; D004327:Drinking Behavior / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D004052:Diethylnitrosamine; D010634:Phenobarbital