Aerosolised liposomal hamycin for treatment of systemic Candida infections in mice.
Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing hamycin liposomes. The drug, when administered twice daily for 2 h (0.68 mg kg(-1) body weight per day) on days 1, 2 and 3 post inoculation, significantly reduced the numbers of Candida organisms in the kidneys. Aerosol treatment increased the survival time of mice given two 2-h treatments once a week for 4 weeks. A twice weekly 2-h small particle aerosol administration of hamycin for 1, 2, or 3 weeks significantly increased both the mean time of survival and percent survival.
Dhuley
J N
JN
Department of Pharmacology and Toxicology, Hindustan Antibiotics Ltd., Pimpri, Pune, India.
D000336:Aerosols; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy* / Q000401:mortality; D004334:Drug Administration Schedule; D004337:Drug Carriers; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011090:Polyenes / Q000008:administration & dosage; D014018:Tissue Distribution
D000336:Aerosols; D004337:Drug Carriers; D008081:Liposomes; D011090:Polyenes; C100114:hamycin