Immune modulation by proteins secreted from cells infected by vaccinia virus.
Vaccinia virus comprises the live vaccine that was used for vaccination against smallpox. Following the eradication of smallpox, vaccinia virus was developed as an expression vector that is now used widely in biological research and vaccine development. In recent years vaccinia virus and other poxviruses have been found to express a collection of proteins that block parts of the host response to infection. Some of these proteins are secreted from the infected cell where they bind and neutralise host cytokines, chemokines and interferons (IFN). In this paper three such proteins that bind interleukin (IL)-1 beta, type I IFNs and CC chemokines are described. The study of these immunomodulatory molecules is enhancing our understanding of virus pathogenesis, yielding fundamental information about the immune system, and providing new molecules that have potential application for the treatment of immunological disorders or infectious diseases.
Smith
G L
GL
Sir William Dunn School of Pathology, University of Oxford, U.K.
Symons
J A
JA
Alcamí
A
A
D000818:Animals; D019742:Chemokines, CC / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D009500:Neutralization Tests; D011485:Protein Binding; D014615:Vaccinia / Q000276:immunology* / Q000821:virology; D014616:Vaccinia virus / Q000254:growth & development / Q000276:immunology / Q000378:metabolism*; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism*
D019742:Chemokines, CC; D007370:Interferon Type I; D007375:Interleukin-1; D014764:Viral Proteins