title: Is radiosensitive cell line cross-sensitive to heat?: Effect of heat on two rat yolk sac tumor cell lines with different radiosensitivity.
abstract: The differences between two rat yolk sac tumor cell lines, which are of the same origin but differ in their response to irradiation, in thermal sensitivity and development of thermotolerance were investigated. A radiosensitive cell line NMT-1 is consistently less heat sensitive than the radioresistant cell line NMT-1R. The thermotolerances in NMT-1 and in NMT-1R preheated at 43 degrees C for 30 min, respectively, reached peaks at 6 h and at 12 h, but did not completely disappear at 48 h. Thermotolerance with a good correlation between both cell lines with HSP70 accumulation was observed in a different time course after a primary heating.
authors.affiliation: Department of Radiology and Radiation Oncology, Gunma University School of Medicine, Maebashi, Japan. nmihashi@sb.gunma-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Mitsuhashi
authors.forename: M S
authors.initials: MS
authors.lastname: Islam
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: O
authors.initials: O
authors.lastname: Murata
authors.forename: K
authors.initials: K
authors.lastname: Maebayashi
authors.forename: M
authors.initials: M
authors.lastname: Nozaki
authors.forename: T
authors.initials: T
authors.lastname: Akimoto
authors.forename: H
authors.initials: H
authors.lastname: Muramatsu
authors.forename: H
authors.initials: H
authors.lastname: Niibe
mesh_terms: D000818:Animals; D015153:Blotting, Western; D018240:Endodermal Sinus Tumor; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis*; D006358:Hot Temperature; D015151:Immunoblotting; D011836:Radiation Tolerance; D051381:Rats; D013696:Temperature; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000528:radiation effects
chemical_list: D018840:HSP70 Heat-Shock Proteins