title: Tumors of the soft tissues composed of large eosinophilic cells.
abstract: Soft tissue neoplasms composed of large eosinophilic cells include benign and malignant tumors with different degrees of biological aggressiveness. The main histotypes discussed in this review are the heterogeneous group of benign and malignant granular cell tumors with neural and non-neural differentiation, alveolar soft part sarcomas, rhabdomyomas, and rhabdomyosarcomas. The salient anatomic, clinical, morphological, and immunophenotypic features in differential diagnosis with metastatic melanomas, carcinomas, and paragangliomas are discussed separately for each histotype.
authors.affiliation: Servizio di Anatomia Patologica, Ospedale Civile di Bassano del Grappa, ULSS 3 Regione Veneto, Bassano del Grappa, Italy.
authors.forename: E S
authors.initials: ES
authors.lastname: d'Amore
authors.forename: V
authors.initials: V
authors.lastname: Ninfo
mesh_terms: D018249:Adenoma, Oxyphilic / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D004804:Eosinophils / Q000473:pathology*; D005887:Gingival Neoplasms / Q000737:chemistry / Q000473:pathology; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology; D006801:Humans; D019042:Muscle Neoplasms / Q000737:chemistry / Q000473:pathology; D018317:Nerve Sheath Neoplasms / Q000737:chemistry / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry / Q000473:pathology; D012207:Rhabdomyoma / Q000737:chemistry / Q000473:pathology; D018234:Sarcoma, Alveolar Soft Part / Q000737:chemistry / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor