title: Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella.
abstract: Secobatzelline A (1), a new batzelline natural analogue, and secobatzelline B (2), a likely artifact formed during the isolation procedure, have been isolated from a deep-water marine sponge of the genus Batzella. Secobatzellines A and B inhibited the phosphatase activity of calcineurin, and secobatzelline A inhibited the peptidase activity of CPP32. Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described.
authors.affiliation: Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, USA. sgunaseker@hboi.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Gunasekera
authors.forename: P J
authors.initials: PJ
authors.lastname: McCarthy
authors.forename: R E
authors.initials: RE
authors.lastname: Longley
authors.forename: S A
authors.initials: SA
authors.lastname: Pomponi
authors.forename: A E
authors.initials: AE
authors.lastname: Wright
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D019703:Calcineurin / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D011161:Porifera / Q000737:chemistry*; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D011480:Protease Inhibitors; C400359:secobatzelline A; C400360:secobatzelline B; D019703:Calcineurin