title: Origin and evolution of binucleate cells in cultures of HEp-2 cells.
abstract: The origin and evolution of binucleate cells in cultures of HEp-2 cells have been studied by means of interval photography and time-lapse video-recording. Binucleate cells most frequently formed by the fusion of two sister cells born in a previous mitosis. The study of binucleate cells has shown that they are a cellular type able to successfully undergo mitosis. However, the mitosis may be bipolar, tripolar or multipolar. The daughter cells arising from these divisions do not follow a clear pattern in the number of nuclei they have, instead showing a wide range of possibilities.
authors.affiliation: Departament de Biologia Animal, Universitat de València, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Serrano
authors.forename: V
authors.initials: V
authors.lastname: Rodilla
authors.forename: J A
authors.initials: JA
authors.lastname: Pellicer
authors.forename: J
authors.initials: J
authors.lastname: Pertusa
mesh_terms: D002277:Carcinoma / Q000473:pathology*; D002459:Cell Fusion; D002467:Cell Nucleus / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008938:Mitosis; D014407:Tumor Cells, Cultured