title: Secondary acute myeloid leukemia 4 years after the diagnosis of hairy cell leukemia: case report and review of the literature.
abstract: A 49-year-old man diagnosed with hairy cell leukemia (HCL) achieved a complete remission lasting 4 years after treatment with cladrabine and subsequently developed acute myeloid leukemia. Although a wide variety of second malignancies have been noted in HCL with an incidence of 8.7%, acute myeloid leukemia (AML) has been reported only once previously in a splenectomized patient who had been treated with alpha interferon.
authors.affiliation: Department of Medicine, Princess Margaret Hospital, Toronto, Ont., Canada.
authors.forename: F
authors.initials: F
authors.lastname: Al-Fiar
authors.forename: J
authors.initials: J
authors.lastname: Meharchand
authors.forename: J
authors.initials: J
authors.lastname: Curtis
authors.forename: J H
authors.initials: JH
authors.lastname: Lipton
mesh_terms: D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017338:Cladribine / Q000627:therapeutic use; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D017338:Cladribine