title: Aggressive (malignant) epithelial odontogenic ghost cell tumor.
abstract: A 57-year-old man had an expanding cystic lesion of the anterior maxilla that demonstrated destruction and disruption of local structures. A cystic odontogenic neoplasm as well as various forms of odontogenic carcinoma was suspected. Incisional biopsy and microscopic examination revealed an aggressive epithelial odontogenic tumor with histologic features suggesting malignant transformation from an odontogenic cyst. The patient continues to refuse further treatment despite remaining tumor. This case further documents the malignant potential of a calcifying odontogenic cyst and the existence of at least an aggressive or possibly malignant form of epithelial odontogenic ghost cell tumor. To date, metastatic work-up has not been performed.
authors.affiliation: Oral &amp Maxillofacial Pathology, Armed Forces Institute of Pathology, Washington, DC, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Castle
authors.forename: D M
authors.initials: DM
authors.lastname: Arendt
mesh_terms: D000328:Adult; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D018333:Odontogenic Cyst, Calcifying / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed