title: Use of corticosteroids in glomerulonephritis related to infective endocarditis: three cases and review.
abstract: We report the cases of three patients treated for infective endocarditis (IE) for whom corticosteroids were added to the antibiotic treatment. They all had clinical and biological evidence of immune-mediated glomerulonephritis. The microorganisms responsible for IE were Coxiella burnetii, Streptococcus bovis, and Cardiobacterium hominis. Median duration of IE before antimicrobial therapy was 7 months. In all patients, renal function deteriorated despite appropriate antimicrobial treatment for a mean duration of 16 days, but it improved after addition of corticosteroid therapy. All patients were cured of IE. A literature review revealed four additional cases of IE-related glomerulonephritis in which adjunctive immunosuppressive therapy was considered to be effective. Although corticosteroid therapy is generally not recommended for IE, it should be considered for patients whose renal dysfunction secondary to glomerulonephritis does not improve with appropriate antimicrobial treatment, especially if the duration of the illness is long.
authors.affiliation: Department of Infectious and Tropical Diseases, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Le Moing
authors.forename: F
authors.initials: F
authors.lastname: Lacassin
authors.forename: M
authors.initials: M
authors.lastname: Delahousse
authors.forename: X
authors.initials: X
authors.lastname: Duval
authors.forename: P
authors.initials: P
authors.lastname: Longuet
authors.forename: C
authors.initials: C
authors.lastname: Leport
authors.forename: J L
authors.initials: JL
authors.lastname: Vildé
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D011241:Prednisone