Pulmonary toxoplasmosis in bone marrow transplant recipients: report of two cases and review.
Toxoplasma gondii may cause disseminated disease in bone marrow transplant (BMT) recipients. Pulmonary toxoplasmosis in BMT patients is rarely described. Mortality rates of >90% have been previously reported. Since pulmonary toxoplasmosis is extremely difficult to diagnose, it is very often detected only at autopsy. Two cases of pulmonary toxoplasmosis in BMT recipients that were diagnosed by visualization of T. gondii tachyzoites in bronchoalveolar lavage fluid and by a new semi-nested PCR method amplifying 18S rRNA from bronchoalveolar lavage fluid are presented, and the literature on pulmonary toxoplasmosis in BMT patients is reviewed.
Sing
A
A
Max-von-Pettenkofer-Institut für Hygiene and Medizinische Mikrobiologie, and Medizinische Klinik III, Ludwig-Maximilians-Universität, Munich, Germany. sing@m3401.mpk.med.uni-muenchen.de
Leitritz
L
L
Roggenkamp
A
A
Kolb
H J
HJ
Szabados
A
A
Fingerle
V
V
Autenrieth
I B
IB
Heesemann
J
J
D000328:Adult; D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000469:parasitology; D016054:DNA, Protozoan / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008174:Lung Diseases, Parasitic / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D014122:Toxoplasma / Q000235:genetics / Q000302:isolation & purification / Q000648:ultrastructure; D014123:Toxoplasmosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
D016054:DNA, Protozoan