Transcription Factors and Hypopituitarism.
Several homeodomain factors are found in the developing anterior pituitary lobe. The production of these developmental transcription factors has distinct temporal and spatial patterns. By interacting with each other, as well as with other extrinsic and intrinsic signals, they control cell determination and specification. Here, we discuss transcription factors that have been shown to have an in vivo role in pituitary cell-type specification.
Cohen
LE
Children's Hospital, Department of Medicine, Division of Endocrinology, 300 Longwood Avenue, Boston, MA 02115, USA.
Radovick
S
Wondisford
FE