New insights into the pathogenesis of interstitial nephritis.
Emerging data on the role of interstitial inflammation in progressive renal disease are redefining our understanding of the pathogenic mechanisms of chronic kidney damage. Recent experimental evidence emphasizes the role for both immune and non-immune mechanisms in interstitial nephritis. New observations regarding maneuvers that downregulate such injurious renal responses may direct further studies that develop new therapeutic modalities.
Meyers
C M
CM
University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia 19104, USA. meyersc@mail.med.upenn.edu
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism; D007684:Kidney Tubules / Q000276:immunology; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000276:immunology; D009569:Nitric Oxide / Q000378:metabolism; D011507:Proteinuria / Q000150:complications; D016212:Transforming Growth Factor beta / Q000378:metabolism
D018925:Chemokines; D016212:Transforming Growth Factor beta; D000804:Angiotensin II; D009569:Nitric Oxide; D007371:Interferon-gamma