Noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil.
OBJECTIVE
To describe a case of transient, noninfectious crystalline keratopathy after postoperative subconjunctival 5-fluorouracil.


METHODS
Case report. Slit-lamp biomicroscopic examinations were performed during serial office examinations.


RESULTS
A 69-year-old woman underwent an uncomplicated trabeculectomy with adjunctive sponge 5-fluorouracil application for 5 minutes in her left eye. Postoperative treatment included topical prednisolone acetate, ciprofloxacin, and scopolamine. She was initially examined with intrastromal corneal crystalline deposits 5 days after her first postoperative subconjunctival injection of 5-fluorouracil. The deposits completely disappeared 4 days later without addition to or change in treatment.


CONCLUSIONS
Transient, noninfectious, crystalline, intrastromal corneal deposits may develop after adjunctive subconjunctival 5-fluorouracil administration.
Rothman
R F
RF
Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA. rrothman@nyee.edu
Liebmann
J M
JM
Ritch
R
R
D000368:Aged; D000963:Antimetabolites / Q000009:adverse effects*; D003228:Conjunctiva; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D017889:Exfoliation Syndrome / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D014130:Trabeculectomy
D000963:Antimetabolites; D005472:Fluorouracil