Expression of transforming growth factor-beta superfamily receptors in developing rat eyes.
OBJECTIVE
To ascertain the role played by the transforming growth factor (TGF)-beta superfamily in retinal development by determining the changes in the expression patterns of their receptors during development of the normal rat retina.


METHODS
The expression of type I and type II receptors of the TGF-beta superfamily was observed at the protein level in rat eyes at embryonic age 17 days (E17), at birth (P0), at postnatal days 3, 6, 9, and at 11 weeks (P3, P6, P9, and adult, respectively).


RESULTS
Activin type I receptor and BMP type IB receptor were first detected in P6 and P3 retinas, respectively, at the protein level, and activin type II receptor was first detected in the P0 retina. The other receptors (TGF-beta type I and II receptors, activin type IB receptor, BMP types IA and II receptors) were detected at E17. The period from P0 to P9 corresponded to the period of dynamic changes in the rat retinal development.


CONCLUSIONS
The results suggest that the expression of TGF-beta superfamily is regulated along with retinal development and may be related to retinal development.
Yamada
H
H
Department of Ophthalmology, Faculty of Medicine, University of Tokyo, Japan.
Obata
H
H
Kaji
Y
Y
Yamashita
H
H
D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; D000818:Animals; D052005:Bone Morphogenetic Protein Receptors, Type I; D052006:Bone Morphogenetic Protein Receptors, Type II; D007124:Immunoenzyme Techniques; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D017978:Receptors, Growth Factor / Q000378:metabolism; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*; D012160:Retina / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism
D017978:Receptors, Growth Factor; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D030301:Activin Receptors, Type II; C498220:Bmpr2 protein, rat; D052005:Bone Morphogenetic Protein Receptors, Type I; D052006:Bone Morphogenetic Protein Receptors, Type II; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; C000625843:Tgfbr1 protein, rat