title: Regional cerebral blood flow abnormalities in chronic solvent abusers.
abstract: This study aimed to reveal regional abnormalities of cerebral blood flow (CBF) and their relation to amotivational syndrome which causes poor social prognosis in solvent abusers Sixteen chronic solvent abusers (12 males and four females) along with five normal subjects underwent single photon emission computed tomography with N-isopropyl-p[123I]iodoamphetamine. The patients received a clinical evaluation with the Scale for the Assessment of Negative Symptoms. Using a semiquantitative method (normalized by the parietal cortex count), patients showed a statistically significant decrease in regional cerebral blood flow (rCBF) in the bilateral prefrontal cortices (P<0.01). In addition, the severity of hypoperfusion in the bilateral prefrontal cortices was related to the degree of severity of the avolition-apathy scale on SANS (left; P<0.05, right; P<0.01) even after excluding the effect of antipsychotics. These results suggest that rCBF abnormalities, especially in the prefrontal cortex, develop in chronic solvent abusers, and that this frontal hypoperfusion may be a biological basis of amotivational syndrome.
authors.affiliation: Department of Neuropsychiatry, Chiba University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: N
authors.initials: N
authors.lastname: Yamanouchi
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: S
authors.initials: S
authors.lastname: Noda
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000139:chemically induced / Q000000981:diagnostic imaging; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009042:Motivation; D017397:Prefrontal Cortex / Q000098:blood supply; D011569:Psychiatric Status Rating Scales; D012039:Regional Blood Flow / Q000187:drug effects; D012917:Social Adjustment; D012997:Solvents / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D012997:Solvents