Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.
A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.
Groutas
W C
WC
Department of Chemistry, Wichita State University, KS 67260, USA.
Schechter
N M
NM
He
S
S
Yu
H
H
Huang
P
P
Tu
J
J
D053818:Chymases; D003499:Cyclic S-Oxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism*; D012867:Skin / Q000201:enzymology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D003499:Cyclic S-Oxides; D004791:Enzyme Inhibitors; D013830:Thiadiazoles; D012697:Serine Endopeptidases; D053818:Chymases