Fatal status epilepticus associated with olanzapine therapy.
OBJECTIVE
To report a case of fatal status epilepticus in a patient using olanzapine with no known underlying cause or predisposing factor for seizure.


METHODS
A 41-year-old white woman developed witnessed seizures at home that progressed to status epilepticus. She subsequently died from secondary rhabdomyolysis and disseminated intravascular coagulation. She had been taking olanzapine for five months prior to the event. No other toxic, metabolic, or anatomic abnormalities were identified pre- or postmortem to explain the seizures. Her seizures were a probable adverse drug reaction based on the Naranjo scale.


CONCLUSIONS
This is the first case of fatal status epilepticus described that has been associated with the use of olanzapine. The pharmacodynamics of olanzapine are similar to those of clozapine, which has been described to induce seizures in 1-4% of patients. It is possible that this patient may have suffered seizures due to a similar effect. Alternate explanations include neuroleptic malignant syndrome and alcohol or benzodiazepine withdrawal seizures, although her clinical history does not suggest these etiologies.


CONCLUSIONS
Although olanzapine has infrequently been associated with seizures in premarketing studies, its potential to induce them exists. Postmarketing surveillance should continue to determine how significant this effect may be.
Wyderski
R J
RJ
Department of Internal Medicine, School of Medicine, Wright State University, Dayton, OH 45409, USA. rjwyderski@mvh.org
Starrett
W G
WG
Abou-Saif
A
A
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D012307:Risk Factors; D013226:Status Epilepticus / Q000139:chemically induced* / Q000503:physiopathology
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine