Effects of verapamil and CSL antivenom on Chironex fleckeri (box-jellyfish) induced mortality.
Ovine antivenom prolonged survival in mice challenged with intravenous Chironex fleckeri venom over a limited dose range. Verapamil enhanced the beneficial effect of ovine antivenom. This data suggests that there may be an, as yet undefined, optimal antivenom dose for humans and that verapamil, used in combination with antivenom is an effective agent.
Bloom
D A
DA
Department of Dermatology, School of Medicine, University of Maryland, Baltimore 21201, USA. jburnett@umaryland.edu
Burnett
J W
JW
Hebel
J R
JR
Alderslade
P
P
D000818:Animals; D000997:Antivenins / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003064:Cnidarian Venoms / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003131:Combined Modality Therapy; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D012756:Sheep; D014700:Verapamil / Q000494:pharmacology*
D000997:Antivenins; D002121:Calcium Channel Blockers; D003064:Cnidarian Venoms; D014700:Verapamil