title: Antithrombotic effects of low-molecular-weight heparin calcium (LMWH-Ca) in experimental models.
abstract: The antithrombotic activity of low-molecular-weight heparin calcium (LMWH-Ca) was studied in venous and arterial thrombosis models, arterial thrombosis model in rats, arterio-venous shunt model and venous thrombosis model in rabbits. The data showed that LMWH-Ca reduced thrombus formation in a dose-dependent manner. It suggests that LMWH-Ca is a potent antithrombotic agent for venous thrombosis, and also may be a beneficial therapeutic agent in arterial thrombosis.
authors.affiliation: Department of Pharmacology, China Pharmaceutical University, Nanjing, PRC. phamcol@mailbox.cpu.edu.cn
authors.forename: H
authors.initials: H
authors.lastname: Ji
authors.forename: S P
authors.initials: SP
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.forename: H R
authors.initials: HR
authors.lastname: Cheng
authors.forename: T B
authors.initials: TB
authors.lastname: Ng
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: N S
authors.initials: NS
authors.lastname: Li
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001166:Arteriovenous Shunt, Surgical; D003328:Coronary Thrombosis / Q000188:drug therapy*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; C006871:calcium heparin; D006493:Heparin