title: Complete remission in acute myeloid leukaemia with t(8;21) following treatment with G-CSF: flow cytometric analysis of in vivo and in vitro effects on cell maturation.
abstract: A 75-year-old patient diagnosed as having acute myeloid leukaemia with t(8;21) received G-CSF alone as induction therapy. Complete remission was achieved following 2 weeks of treatment. Flow cytometric analysis, performed by CD45 technique modified by the introduction of preliminary gating with LDS-751, confirmed the disappearance of blast cells along with myeloid maturation. Finally, in vitro studies demonstrated that G-CSF, as compared to other differentiation inducers, was able to induce a striking effect toward neutrophilic differentiation.
authors.affiliation: Division of Haematology, Cardarelli General Hospital, Napoli, Italy. ferrara@itb.it
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: R
authors.initials: R
authors.lastname: Di Noto
authors.forename: A
authors.initials: A
authors.lastname: Viola
authors.forename: C
authors.initials: C
authors.lastname: Russo
authors.forename: P
authors.initials: P
authors.lastname: Boccuni
authors.forename: S
authors.initials: S
authors.lastname: Costantini
authors.forename: A
authors.initials: A
authors.lastname: Dello Russo
authors.forename: C
authors.initials: C
authors.lastname: Lo Pardo
authors.forename: L
authors.initials: L
authors.lastname: Del Vecchio
mesh_terms: D000208:Acute Disease; D000368:Aged; D002455:Cell Division; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005434:Flow Cytometry; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D016179:Granulocyte Colony-Stimulating Factor