title: Cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis.
abstract: In order to find out the relationship between the cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis, 10 cases of asymptomatic cerebral infarction and 10 age-matched control subjects were studied. The cerebrovascular acetazolamide reactivity was measured using xenon computed tomography method. As markers of platelet function, the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were determined. The cerebrovascular acetazolamide reactivity was significantly lower in the asymptomatic cerebral infarction group than in the control group. The plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were higher in the asymptomatic cerebral infarction group than in the control group. There was a significant negative correlation between the cerebrovascular acetazolamide reactivity and the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2. The low cerebrovascular acetazolamide reactivity is considered to be related to platelet activation in asymptomatic cerebral thrombosis.
authors.affiliation: Department of Neurology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Oishi
authors.forename: Y
authors.initials: Y
authors.lastname: Mochizuki
mesh_terms: D000086:Acetazolamide; D000368:Aged; D001160:Arterioles / Q000187:drug effects; D002257:Carbonic Anhydrase Inhibitors; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D010978:Platelet Factor 4 / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014980:Xenon Radioisotopes; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D014980:Xenon Radioisotopes; D001620:beta-Thromboglobulin; D010978:Platelet Factor 4; D000086:Acetazolamide