Effect of compression speeds on the compaction properties of a 1:1 paracetamol-microcrystalline cellulose mixture prepared by single compression and by combinations of pre-compression and main-compression.
A 1:1 blend of paracetamol and microcrystalline cellulose was compacted at different compression speeds by single compression or combinations of pre- and main-compression. The tensile strengths of the tablets decreased from 0.74+/-0.01 to 0.44+/-0.05 MPa as the compression speed was increased from 78 to 390 mm/s when a single compression pressure of 80 MPa was used to compress the tablets. When combinations of pre- and main-compression of 320 and 240 MPa were used to compress the tablets, tensile strengths decreased from 3.12+/-0.67 MPa at a compression speed of 78 mm/s to 1.24+/-0.36 MPa when the compression speed was 390 mm/s. The energies of compression and the ratio of elastic to plastic energies increased with increase in compression speed. This was because the material was becoming more elastic and more energy was required for the elastic expansion leading to a reduction in the energy available for plastic deformation and bond formation which resulted in a decrease in tensile strengths. Pre-compression played a major role at high compression speeds. The tensile strengths of tablets (1.2+/-0.08 MPa) compressed with a pre-compression of 160 MPa followed by a main-compression of 80 MPa (compression speed of 390 mm/s) were similar to the tensile strengths of tablets (1.1+/-0.10 MPa) compressed using a single compression of 320 MPa at the same compression speed of 390 mm/s. Thus, combinations of lower pressures can be employed to compress the material to the same tensile strength as a high single compression.
Akande
OF
Pharmaceutical Technology and Drug Delivery Group, School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, England, UK
Rubinstein
MH
Rowe
PH
Ford
JL