title: Supplementary report on experimental autumn crocus (Colchicum autumnale L.) poisoning in cattle: morphological evidence of apoptosis.
abstract: Previously we reported that tissue destruction characterized by the presence of karyopyknotic, karyorrhectic and mitotically arrested cells was seen in alimentary epithelial cells and lymphocytes in the lymphoid and hemopoietic systems of cattle experimentally administered with autumn crocus (Colchicum autumnale L.). This report deals with the mechanism of acute cellular injury following experimental autumn crocus poisoning in cattle as demonstrated by the in situ DNA strand break analysis and electron microscopy. The analyses revealed that cellular injury caused by autumn crocus was closely associated with apoptosis.
authors.affiliation: Department of Veterinary Pathology, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Furuoka
authors.forename: M
authors.initials: M
authors.lastname: Haritani
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D017209:Apoptosis; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology* / Q000503:physiopathology; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology; D002843:Chromatin / Q000187:drug effects / Q000473:pathology; D003079:Colchicum / Q000633:toxicity*; D003593:Cytoplasm / Q000473:pathology; D004064:Digestive System / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D020287:In Situ Nick-End Labeling; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D007421:Intestine, Small / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008938:Mitosis; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011041:Poisoning / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D013154:Spleen / Q000187:drug effects / Q000473:pathology
chemical_list: D002843:Chromatin