Different gastritis features are linked to different gastric neoplasms.
OBJECTIVE
Helicobacter pylori infection induces gastritis, which may evolve to carcinoma or lymphoma. Whether duration of infection and inflammation pattern determine the outcome of the neoplastic process is not known. The aim of this study was to investigate the features of the gastritis associated with neoplasia.


METHODS
Gastritis found in association with carcinoma (100 cases) and lymphoma (45 cases) were graded using the Sydney system.


RESULTS
In particular in the antrum, gastric carcinomas, in particular of the intestinal type, were associated with a chronic (94%, n = 34/36) atrophic (92%, n = 33/36) gastritis and intestinal metaplasia (81%, n = 29/36). In diffuse type carcinomas inflammation was either absent or mild. An active (64%, n = 16/25), chronic gastritis (100%, n = 25/25) with lymphoid hyperplasia (72%, n = 18/25) was found in marginal zone cell lymphoma.


CONCLUSIONS
Our study shows that the (pre)atrophic phases of inflammation are associated with gastric carcinomas. In contrast the active phase of inflammation, characterized by severe activity as well as severe chronicity, is found next to marginal zone cell lymphoma.
Driessen
A
A
Department of Pathology, University Hospitals K.U. Leuven, Belgium.
Ectors
N
N
Van Cutsem
E
E
Penninckx
F
F
Filez
L
L
Pittaluga
S
S
Delabie
J
J
De Wolf-Peeters
C
C
Geboes
K
K
D000328:Adult; D000368:Aged; D001284:Atrophy; D002277:Carcinoma / Q000150:complications / Q000382:microbiology / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D005756:Gastritis / Q000145:classification / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori / Q000254:growth & development; D006801:Humans; D008223:Lymphoma / Q000150:complications / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications* / Q000382:microbiology / Q000473:pathology