Pathological evaluation of renal tumors in children: international society of pediatric oncology approach.
In the majority of European countries, children with renal tumors now enter the SIOP-93-01 Trial and Study. The objective of this Study is to refine methods of treatment especially in stage I patients. The role of institutional pathologists is important in this trial. There are new criteria for stages I and II, a new SIOP Working Classification of Renal Tumors of Childhood, and morphologic and prognostic similarities of pretreated and non-pretreated anaplastic cases. Specific problems encountered in assessing tumors treated with preoperative chemotherapy, administered to the majority of children over 6 months of age entering the SIOP Study, are discussed. The identification of a new low-risk group, the completely necrotic Wilms tumor, is outlined.
Boccon-Gibod
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LA
Department of Pediatric Pathology, Hôpital d'Enfants Armand-Trousseau, Paris, France.
D000708:Anaplasia / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005602:France; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D008495:Medical Oncology; D009367:Neoplasm Staging; D009396:Wilms Tumor / Q000473:pathology / Q000628:therapy