title: Host determinants of Helicobacter pylori infection and its clinical outcome.
abstract: Greater than one-half of the world's population harbors Helicobacter pylori. The majority of infected individuals, however, remain asymptomatic, with only 10% to 20% developing diseases, including peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. This article reviews host factors that may predispose an individual to both the acquisition of H. pylori infection and subsequent clinical outcome. Individuals with specific blood group antigens and human leukocyte antigen genotypes may be more susceptible to H. pylori infection. Additional factors, such as the age of acquisition, the host immune response, the site of infection, acid secretion, and interactions with nonhost factors (including bacterial virulence factors and environmental influences) may play a role in determining clinical outcome. Further investigation is required to clarify the mechanisms by which these interactions occur and, more critically, to determine their relative importance. This knowledge will enable the identification of individuals at risk of developing clinical disease with H. pylori infection.
authors.affiliation: Division of Gastroenterology, McGill University, Montreal, Quebec, Canada.
authors.forename: T N
authors.initials: TN
authors.lastname: Nguyen
authors.forename: A N
authors.initials: AN
authors.lastname: Barkun
authors.forename: C A
authors.initials: CA
authors.lastname: Fallone
mesh_terms: D004198:Disease Susceptibility; D005260:Female; D016481:Helicobacter Infections / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology / Q000276:immunology / Q000382:microbiology; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology / Q000276:immunology / Q000382:microbiology