Histopathologic comparison of human coronary in-stent and post-balloon angioplasty restenotic tissue.
Histomorphometric studies for smooth muscle cells, macrophages, tissue factor, collagen, and cell proliferation were performed on 20 atherectomy specimens from patients with in-stent restenosis and 20 specimens from patients with post-balloon PTCA restenosis. Smooth muscle cell content was larger and proliferation index was higher in in-stent restenotic tissue; macrophage, tissue factor, and collagen content were larger in post-balloon percutaneous transluminal coronary angioplasty restenotic tissue, suggesting a more cellular and proliferative response with less thrombogenic potential in human tissue from in-stent restenosis than tissue from post-balloon percutaneous transluminal coronary angioplasty restenosis.
Moreno
P R
PR
The Gill Heart Institute, University of Kentucky, Lexington, USA. pmoreno@pop.uky.edu
Palacios
I F
IF
Leon
M N
MN
Rhodes
J
J
Fuster
V
V
Fallon
J T
JT
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D017225:Atherectomy, Coronary; D002455:Cell Division; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006083:Graft Occlusion, Vascular / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000000981:diagnostic imaging / Q000473:pathology; D011475:Prosthesis Failure; D015607:Stents; D018084:Ultrasonography, Interventional