title: Effect of venlafaxine hydrochloride in different preparations of isolated guinea-pig and rat organ tissues.
abstract: A study was undertaken to know better the effects of venlafaxine hydrochloride on the responses of isolated rat vas deferens to noradrenaline and dopamine, those of isolated rat uterus to serotonin and histamine, and those of isolated guinea-pig ileum to acetylcholine and histamine. Venlafaxine hydrochloride increased the response of rat vas deferens to noradrenaline but not to dopamine. Venlafaxine did not alter the response of rat isolated uterus to serotonin. In rat uterus, venlafaxine did not modify the response to histamine but was able to increase it in guinea-pig ileum. An anticholinergic effect was observed with the lowest concentration tested. Although venlafaxine is a selective serotonine reuptake inhibitor in the central nervous system, serotonin uptake was not seen in the rat uterus. The anticholinergic effects observed in the present study might be consistent with some of the side-effects associated with venlafaxine.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Valladolid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Velasco
authors.forename: A
authors.initials: A
authors.lastname: Arruza
authors.forename: M
authors.initials: M
authors.lastname: Maroto
authors.forename: A
authors.initials: A
authors.lastname: Carvajal
authors.forename: E
authors.initials: E
authors.lastname: Fernández del Busto
authors.forename: J
authors.initials: J
authors.lastname: García del Pozo
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D003511:Cyclohexanols / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects; D000069470:Venlafaxine Hydrochloride
chemical_list: D000109:Acetylcholine; D000316:Adrenergic alpha-Agonists; D002316:Cardiotonic Agents; D003511:Cyclohexanols; D004298:Dopamine; D006632:Histamine; D009638:Norepinephrine; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride