title: Injectable bone substitute using a hydrophilic polymer.
abstract: We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to obtain CaP bioactivity in a dental canal or bone defect during percutaneous surgery. Macromolecules provide spaces between CaP ceramic granules and facilitate the role of the biological agents of bone substitution.
authors.affiliation: Equipe INSERM Matériaux d'intérêt Biologique, Faculté de Chirurgie Dentaire, Nantes, France. pweiss@sante.univ-nantes.fr
authors.forename: P
authors.initials: P
authors.lastname: Weiss
authors.forename: O
authors.initials: O
authors.lastname: Gauthier
authors.forename: J M
authors.initials: JM
authors.lastname: Bouler
authors.forename: G
authors.initials: G
authors.lastname: Grimandi
authors.forename: G
authors.initials: G
authors.lastname: Daculsi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D018786:Bone Substitutes / Q000737:chemistry* / Q000494:pharmacology; D002130:Calcium Phosphates / Q000737:chemistry* / Q000494:pharmacology; D005269:Femur / Q000187:drug effects / Q000648:ultrastructure; D020007:Implants, Experimental; D007267:Injections; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010078:Oxazines; D011817:Rabbits; D012212:Rheology; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D010078:Oxazines; C103718:beta-tricalcium phosphate-monocalcium phosphate monohydrate-calcium sulfate hemihydrate mixture; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose