title: Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent.
abstract: This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima-City, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mashiko
authors.forename: S
authors.initials: S
authors.lastname: Niwa
authors.forename: H
authors.initials: H
authors.lastname: Kumashiro
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Numata
authors.forename: R
authors.initials: R
authors.lastname: Horikoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D014196:Trazodone / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone