Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin.
Belaud-Rotureau
M A
MA
Laboratoire d'Hématologie, Hôpital Haut-Levêque, 33604 Pessac, France.
Lacombe
F
F
Durrieu
F
F
Vial
J P
JP
Lacoste
L
L
Bernard
P
P
Belloc
F
F
D017209:Apoptosis; D053148:Caspase 3; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007976:Leupeptins / Q000378:metabolism* / Q000494:pharmacology; D009336:Necrosis; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D020298:U937 Cells; D019014:fas Receptor / Q000378:metabolism
D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D004791:Enzyme Inhibitors; D007976:Leupeptins; C064769:N-acetylsphingosine; D019014:fas Receptor; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; C032854:leupeptin; D013110:Sphingosine