title: A comparison of treatment strategies for endometrial adenocarcinoma: analysis of financial impact.
abstract: OBJECTIVE
  The aim of this study was to investigate the influence of three treatment strategies for adenocarcinoma of the endometrium on the utilization of adjuvant radiation therapy and the medical charges associated with each pattern of practice.
  
  
  METHODS
  Three clinical algorithms felt to represent practice patterns for patients with endometrial cancer were considered: (1) comprehensive surgical staging of all patients, with adjuvant pelvic radiation reserved for documented cases of extrauterine disease, (2) total abdominal hysterectomy with bilateral salpingo-oophorectomy (TAH/BSO) with lymph node dissection reserved for cases of myometrial invasion, followed by adjuvant radiation based on the presence of uterine risk factors, and (3) TAH/BSO followed by intraoperative pathologic assessment of the uterus and consultation with a "surgical" oncologist for comprehensive staging. Each algorithm was applied to a cohort of 190 surgically staged patients identified through a retrospective medical records review. The use of radiation in each algorithm was quantified and the associated financial impact was estimated using hospital charges.
  
  
  RESULTS
  Treatment algorithm 1 yielded the lowest charges per patient at $12,778.52. Treatment algorithms 2 and 3 had associated charges per patient of $15,997.02 and $17,343.44, respectively.
  
  
  CONCLUSIONS
  Approaches to care that lead to cost-effective utilization of health care resources should be pursued.
authors.affiliation: Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama, 35233, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Barnes
authors.forename: P Y
authors.initials: PY
authors.lastname: Roland
authors.forename: M
authors.initials: M
authors.lastname: Straughn
authors.forename: L C
authors.initials: LC
authors.lastname: Kilgore
authors.forename: R D
authors.initials: RD
authors.lastname: Alvarez
authors.forename: E E
authors.initials: EE
authors.lastname: Partridge
mesh_terms: D000230:Adenocarcinoma / Q000191:economics* / Q000473:pathology / Q000628:therapy*; D000465:Algorithms; D017281:Cost of Illness; D016889:Endometrial Neoplasms / Q000191:economics* / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D012189:Retrospective Studies