title: Does early detection of ureteropelvic junction obstruction improve surgical outcome in terms of renal function?
abstract: OBJECTIVE
  Prenatal ultrasound leads to the early detection of hydronephrosis. When followed by the early diagnosis of ureteropelvic junction obstruction surgical treatment, if indicated, is associated with minimal morbidity. We attempt to prove the benefits of this therapeutical approach from the point of view of renal function.
  
  
  METHODS
  From 1979 to 1997, 452 patients with ureteropelvic junction obstruction underwent dismembered pyeloplasty. Of these patients 113 with comparable data were retrospectively evaluated. Patients were divided into group 1-50 who presented with prenatal hydronephrosis and group 2-63 with neonatal hydronephrosis who were lost to followup and who then presented with symptoms leading to the diagnosis of ureteropelvic junction obstruction. In each group the diagnostic criteria and indications for surgery were identical based on symptomatology, ultrasound and renal scan. Patients with bilateral disease, solitary kidney or vesicoureteral reflux were excluded from study. In groups 1 and 2 median patient age at surgery was 11 months and 5 years, and average postoperative followup was 4.2 and 3.2 years, respectively.
  
  
  RESULTS
  In 41 of the 50 group 1 and 60 of the 63 group 2 patients hydronephrosis was severe and the renal pelvis was more than 3 cm. wide. Poor relative renal function (less than 30%) was significantly more pronounced in group 2 than in group 1 (56 of 63 patients or 89% versus 6 of 50 or 12%, p <0.05). In all 113 patients postoperative followup ultrasound and renal scan revealed significant improvement in hydronephrosis and washout curve pattern. There was a significant difference in the 2 groups in regard to renal function improvement postoperatively (66% of group 1 versus 16% of group 2 patients, p <0.05).
  
  
  CONCLUSIONS
  We believe that patients who undergo prenatal imaging and are diagnosed early with ureteropelvic junction obstruction should be carefully and meticulously followed. Special efforts should be made to ensure that patients are not lost to followup. After any sign of deterioration develops early surgery is indicated. According to our data operative treatment results in improved renal function.
authors.affiliation: Department of Urology, Diagnostic Radiology and Nuclear Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Chertin
authors.forename: A
authors.initials: A
authors.lastname: Fridmans
authors.forename: M
authors.initials: M
authors.lastname: Knizhnik
authors.forename: I
authors.initials: I
authors.lastname: Hadas-Halperin
authors.forename: D
authors.initials: D
authors.lastname: Hain
authors.forename: A
authors.initials: A
authors.lastname: Farkas
mesh_terms: D002675:Child, Preschool; D006801:Humans; D006869:Hydronephrosis / Q000503:physiopathology* / Q000601:surgery*; D007223:Infant; D007668:Kidney / Q000503:physiopathology*; D007682:Kidney Pelvis / Q000601:surgery*; D012189:Retrospective Studies; D014517:Ureteral Obstruction / Q000503:physiopathology* / Q000601:surgery*