title: Identification of a hexasaccharide sequence able to inhibit thrombin and suitable for 'polymerisation'.
abstract: Three hexasaccharides, having from low to very high affinity for antithrombin, were synthesised from disaccharide building block precursors. One of them, methyl(sodium 2,3-di-O-methyl-4-O- sodium sulfonato-alpha-L-idopyranosyluronate)-(1-->4)-[(2,3,6-tri-O-sodiu m sulfonato-alpha-D-glucopyranosyl)-(1-->4)-(sodium 2,3-di-O-methyl-alpha-L-idopyranosyluronate)-(1-->4)]2-2,3,6-tri-O-sodiu m sulfonato-alpha-D-glucopyranoside, obtainable from a single disaccharide building block precursor, constitutes a good starting point for obtaining simple oligosaccharidic heparin mimetics able to inhibit the two coagulation factors thrombin and Factor Xa.
authors.affiliation: Sanofi Recherche, Haemobiology Research Department, Toulouse, France.
authors.forename: P
authors.initials: P
authors.lastname: Duchaussoy
authors.forename: G
authors.initials: G
authors.lastname: Jaurand
authors.forename: P A
authors.initials: PA
authors.lastname: Driguez
authors.forename: I
authors.initials: I
authors.lastname: Lederman
authors.forename: F
authors.initials: F
authors.lastname: Gourvenec
authors.forename: J M
authors.initials: JM
authors.lastname: Strassel
authors.forename: P
authors.initials: P
authors.lastname: Sizun
authors.forename: M
authors.initials: M
authors.lastname: Petitou
authors.forename: J M
authors.initials: JM
authors.lastname: Herbert
mesh_terms: D001665:Binding Sites; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry; D007202:Indicators and Reagents; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009904:Optical Rotation; D011108:Polymers; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D007202:Indicators and Reagents; D009844:Oligosaccharides; D011108:Polymers; D006493:Heparin; D013917:Thrombin