title: Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.
abstract: Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACC's over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein.
authors.affiliation: Parke-Davis Pharmaceutical Research Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Schelkun
authors.forename: P
authors.initials: P
authors.lastname: Yuen
authors.forename: T C
authors.initials: TC
authors.lastname: Malone
authors.forename: D M
authors.initials: DM
authors.lastname: Rock
authors.forename: S
authors.initials: S
authors.lastname: Stoehr
authors.forename: B
authors.initials: B
authors.lastname: Szoke
authors.forename: K
authors.initials: K
authors.lastname: Tarczy-Hornoch
mesh_terms: D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D008697:Methane