Complete remission in acute myeloid leukaemia with t(8;21) following treatment with G-CSF: flow cytometric analysis of in vivo and in vitro effects on cell maturation.
A 75-year-old patient diagnosed as having acute myeloid leukaemia with t(8;21) received G-CSF alone as induction therapy. Complete remission was achieved following 2 weeks of treatment. Flow cytometric analysis, performed by CD45 technique modified by the introduction of preliminary gating with LDS-751, confirmed the disappearance of blast cells along with myeloid maturation. Finally, in vitro studies demonstrated that G-CSF, as compared to other differentiation inducers, was able to induce a striking effect toward neutrophilic differentiation.
Ferrara
F
F
Division of Haematology, Cardarelli General Hospital, Napoli, Italy. ferrara@itb.it
Di Noto
R
R
Viola
A
A
Russo
C
C
Boccuni
P
P
Costantini
S
S
Dello Russo
A
A
Lo Pardo
C
C
Del Vecchio
L
L
D000208:Acute Disease; D000368:Aged; D002455:Cell Division; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005434:Flow Cytometry; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor