Vitamin-D receptor genotype does not predict bone mineral density, bone turnover, and growth in prepubertal children.
We examined whether the polymorphism for BsmI restriction enzyme in the vitamin-D receptor (VDR) gene influenced radial (distal third) and lumbar (L2-L4) bone mineral density (BMD), phospho-calcium metabolism (calcium, phosphate, intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D), biochemical markers of bone formation (osteocalcin and carboxy-terminal propeptide of type-I procollagen) and bone resorption (carboxy-terminal telopeptide of type-I collagen and urinary cross-linked N-telopeptides of type I collagen), insulin-like growth factor I and insulin-like growth factor-binding protein 3, and growth in 209 healthy prepubertal children (112 males and 97 females) aged 7.1-10.0 years. Genotype frequencies were BB 19%, Bb 46%, and bb 35% in the pooled group of children. Clinical findings, dietary calcium intake, calcium density, and physical activity rate were not different (p NS) among the VDR genotypes. Radial BMD, lumbar BMDarea and lumbar BMD adjusted for the apparent bone volume (BMDvolume), and all the biochemical parameters did not differ (p NS) in relation to the VDR genotype. In conclusion, our data show that polymorphism for BsmI restriction enzyme in the VDR gene is not associated with radial and lumbar BMD, parameters of phospho-calcium metabolism and bone turnover, growth hormone-dependent growth factors, and growth in prepubertal children.
Baroncelli
G I
GI
Endocrine Unit, Division of Pediatrics, Department of Reproductive Medicine and Pediatrics, University of Pisa, Italy.
Federico
G
G
Bertelloni
S
S
Ceccarelli
C
C
Cupelli
D
D
Saggese
G
G
D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002136:Calcium, Dietary; D002648:Child; D005260:Female; D005838:Genotype; D006128:Growth / Q000235:genetics*; D006801:Humans; D008297:Male; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism
D002136:Calcium, Dietary; D018167:Receptors, Calcitriol; D002118:Calcium