title: Correlation between endoscopic features of gastric antrum, histology and Helicobacter pylori infection in adults.
abstract: BACKGROUND
  Helicobacter pylori induces histologic inflammation of mucosa variably correlated to different macroscopic features. Recent studies highlight that the presence of Helicobacter pylori could be assessed on the basis of the macroscopic pattern only, in particular nodularity. The present prospective study has correlated this and other endoscopic features, defined by Sydney classification of gastritis, both to Helicobacter pylori presence and histological patterns.
  
  
  RESULTS
  Out of 532 patients, 364 were evaluable. The prevalence of Helicobacter pylori was 51.1% with a different distribution between the endoscopic features. Nodularity showed the highest positive predictive value in detecting the Helicobacter pylori presence (69.9%). The histological findings were: normal 26.9%, non atrophic gastritis 55.2%, atrophic gastritis 17.9%. There was a significant difference between abnormal endoscopic features in detecting the histologic gastritis, with endoscopic atrophy and nodularity showing the highest positive predictive value which reaches 96.7% and 91.8%, respectively. Helicobacter pylori infection and histologic gastritis were also present in 30.9% and 41.8%, respectively, of endoscopically normal subjects. Multivariate analysis has strictly correlated age with all abnormal endoscopic features, metaplasia with endoscopic atrophy, and chronic inflammation (gastritis) with nodularity.
  
  
  CONCLUSIONS
  The single endoscopic features are poorly correlated with histologic changes and Helicobacter pylori status. Biopsies are mandatory in all cases. The causes of the different macroscopic findings are not yet fully understood.
authors.affiliation: Department of Internal Medicine and Gastroenterology, University of Bologna, Italy. calabrese.c@usa.net
authors.forename: C
authors.initials: C
authors.lastname: Calabrese
authors.forename: G
authors.initials: G
authors.lastname: Di Febo
authors.forename: G
authors.initials: G
authors.lastname: Brandi
authors.forename: A M
authors.initials: AM
authors.lastname: Morselli-Labate
authors.forename: A
authors.initials: A
authors.lastname: Areni
authors.forename: C
authors.initials: C
authors.lastname: Scialpi
authors.forename: G
authors.initials: G
authors.lastname: Biasco
authors.forename: M
authors.initials: M
authors.lastname: Miglioli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005260:Female; D005756:Gastritis / Q000175:diagnosis* / Q000473:pathology; D020699:Gastroscopes; D005773:Gastroscopy / Q000379:methods / Q000706:statistics & numerical data; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D007422:Intestines / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000473:pathology; D013270:Stomach / Q000473:pathology*