Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols.
Glyco-S-nitrosothiols, fructose-2-SNAP and glucose-2-SNAP, were synthesized and found to be much more cytotoxic than SNAP in killing DU-145 human prostate cancer cells in vitro.
Hou
Y
Y
Department of Chemistry, Wayne State University, Detroit, MI 48201, USA.
Wang
J
J
Andreana
P R
PR
Cantauria
G
G
Tarasia
S
S
Sharp
L
L
Braunschweiger
P G
PG
Wang
P G
PG
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005632:Fructose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009603:Nitroso Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D020030:Nitric Oxide Donors; D009603:Nitroso Compounds; C110881:S-nitro-N-acetylpenicillamine; C400307:fructose-2-SNAP; C400306:glucose-2-SNAP; D005632:Fructose; D009569:Nitric Oxide; D010396:Penicillamine; D005947:Glucose