Radial scar/complex sclerosing lesion--a problem in the diagnostic work-up of screen-detected breast lesions.
During the first 7.5 years of breast cancer screening in South Australia, 88 radial scar/complex sclerosing lesions were among the mammographically detected abnormalities. A false-positive cytological diagnosis by fine needle biopsy was given in three of 69 such cases with satisfactory smears, a false-positive rate of 4.3% in this particular group. A review of the smears suggested that the false-positive diagnoses could have been avoided if a total or near total absence of a benign epithelial component had been included among the criteria for a malignant diagnosis. However, even after review, atypia was considered sufficiently worrying to be reported as a suspicion of malignancy in 7% of cases.
Orell
S R
SR
BreastScreenSA, Wayville, Australia.
D001707:Biopsy, Needle; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D002921:Cicatrix / Q000473:pathology*; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D012598:Sclerosis