Priming stimulation in the basolateral amygdala modulates synaptic plasticity in the rat dentate gyrus.
We investigated the effects of basolateral amygdala (BLA) priming on long-term potentiation (LTP) in the dentate gyrus (DG). In the control animals, the induction of high-frequency stimulation (HFS) to the perforant path (PP) resulted in hippocampal LTP at all the time intervals tested. A priming stimulation to the BLA prior to the application of HFS to the PP resulted in the enhancement of the excitatory post-synaptic potential (EPSP)-LTP and population spike (PS)-LTP in the DG from 90-min post-HFS onwards. These findings suggest that the amygdala has a potential role in the modulation of some aspects of memory that are mediated by the hippocampus.
Akirav
I
I
Department of Psychology, University of Haifa, Israel.
Richter-Levin
G
G
D000200:Action Potentials / Q000502:physiology; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D019580:Perforant Pathway / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology*; D013997:Time Factors