Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo.
Single gene knock-outs in mice have been used to define the biological role of leukocyte adhesion receptors, Fc-gamma receptors and complement in animal models of immune complex glomerulonephritis. These studies have shown important differences in the role of P-selectin in glomerular inflammation and inflammation at other sites, and have given a new appreciation of the dominant role played by Fc-gamma receptors in immune complex-induced glomerular injury.
Mayadas
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Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. tmayadas@bustoff.bwh.harvard.edu
Rosenkranz
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Cotran
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D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D003165:Complement System Proteins / Q000502:physiology; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000209:etiology / Q000235:genetics* / Q000276:immunology*; D007105:Immune Complex Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D017452:Receptors, IgG / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D019087:Selectins / Q000235:genetics / Q000502:physiology
D015815:Cell Adhesion Molecules; D017452:Receptors, IgG; D019087:Selectins; D003165:Complement System Proteins