title: Bone marrow transplant patients with life-threatening organ failure: when should treatment stop?
abstract: OBJECTIVE
  To discuss issues surrounding life support in bone marrow transplant (BMT) patients, issues that may determine how far we go to keep a deteriorating BMT patient alive--and when we stop trying. How can we define survival chance in BMT patients, and when should prolongation of life be deemed inappropriate? Who should make the decision to terminate support? And how should life support be terminated?
  
  
  METHODS
  Prognostic factors that predict for almost certain nonsurvival have been identified in BMT patients with life-threatening organ failure. The concept of futility raises the question of how low the chance of survival must be before termination of life support is justified--but the concept is flawed, and the value judgments involved in decision making must also be considered. Then, once a decision is made, the manner of withholding or withdrawing life support is also open to discussion.
  
  
  CONCLUSIONS
  Despite controversies, there are areas in which improvements to current practice might be considered. More data are required to determine survival chances of BMT patients with life-threatening organ failure. Greater attention might be devoted, in pretransplant counseling, to issues of intensive life support, with the patient's own views being ascertained before transplantation. And, because technologic possibilities are now imposing fewer boundaries, the problem of finite resources may need to be readdressed, with treatment limits being set down before transplantation.
authors.affiliation: Department of Haematology, University College London Hospitals, England.
authors.forename: A R
authors.initials: AR
authors.lastname: Perry
authors.forename: M M
authors.initials: MM
authors.lastname: Rivlin
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D016223:Advance Directives; D016026:Bone Marrow Transplantation; D005066:Euthanasia, Passive; D006801:Humans; D008020:Life Support Care; D018447:Medical Futility; D009102:Multiple Organ Failure / Q000628:therapy*; D010344:Patient Advocacy; D012307:Risk Factors