(-)-Pindolol increases dialysate concentrations of dopamine and noradrenaline, but not serotonin, in the frontal cortex of freely-moving rats.
(-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels were not significantly modified. In contrast, (-)-propranolol (2.5) did not modify FCX dialysate levels of DA, NA (or 5-HT) alone and abolished the facilitatory influence of (-)-pindolol (10.0) upon levels of DA, though not NA. In contrast to (-)-propranolol, (-)-pindolol exerts, a facilitatory influence upon frontocortical dopaminergic and adrenergic, but not serotonergic, transmission.
Millan
M J
MJ
Institut de Recherches Servier, Psychopharmacology Department, Paris, France.
Gobert
A
A
D000818:Animals; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009068:Movement / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D010869:Pindolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D010869:Pindolol; D004298:Dopamine; D009638:Norepinephrine