title: Castleman disease presenting with ophthalmic signs and symptoms.
abstract: OBJECTIVE
  To describe a patient with multicentric Castleman disease who was initially examined with ophthalmic signs and symptoms.
  
  
  METHODS
  Case report. A 71-year-old man was initially examined with swelling of both upper eyelids and diplopia of 2 months' duration.
  
  
  RESULTS
  Medical evaluation and right axillary lymph node biopsy disclosed Castleman disease. Systemic corticosteroid treatment temporarily resolved signs and symptoms, but the patient died of recurrence with cytomegalovirus and Aspergillus infection 10 months after initial examination.
  
  
  CONCLUSIONS
  Multicentric Castleman disease is a rare but distinct disorder that may present initially with ocular signs and symptoms. This disease must be included in the differential diagnosis of orbital pseudotumor and lymphoma.
authors.affiliation: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kurokawa
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: N
authors.initials: N
authors.lastname: Fujisawa
authors.forename: N
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D001228:Aspergillosis / Q000150:complications; D005871:Castleman Disease / Q000175:diagnosis* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000150:complications; D004172:Diplopia / Q000175:diagnosis* / Q000188:drug therapy; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000188:drug therapy; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; C009935:prednisolone acetate; D011239:Prednisolone