Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs.
The phytochemical investigation of Arum palaestinum resulted in the isolation of two flavone C-glucosides, namely isoorientin (luteolin 6-C-glucoside) and vitexin (apigenin 8-C glucoside). The effects of isoorientin on rat isolated aorta, ileum, trachea and uterus and on guinea-pig uterus were studied. Isoorientin (10(-7)M-6 x 10(-4)M) caused concentration-dependent inhibition of the amplitude and the frequency of the phasic contractions of the rat and guinea-pig uterus but did not affect the isolated aorta, ileum or trachea. The results were discussed in relation to the effects of its aglycone luteolin reported in the literature.
Afifi
F U
FU
Faculty of Pharmacy, University of Jordan, Amman. fatueafi@ju.edu.jo
Khalil
E
E
Abdalla
S
S
D000818:Animals; D047310:Apigenin; D004305:Dose-Response Relationship, Drug; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D047311:Luteolin; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D005419:Flavonoids; D047310:Apigenin; C032731:vitexin; C057912:homoorientin; D047311:Luteolin