title: Antimicrobial resistance patterns in urinary isolates from nursing home residents. Fifteen years of data reviewed.
abstract: The antibiotic resistance patterns of gram-negative bacteria isolated from nursing home patients between 1983 and 1997 were analysed. Escherichia coli was the most prevalent isolate (48%) followed by Proteus spp. (26%) and other Enterobacteriaceae (20%). During the study period, the susceptibility of E. coli decreased for co-trimoxazole (79% to 62%), increased for nitrofurantoin (79% to 91%) and remained unchanged for amoxycillin (41%). Susceptibility to norfloxacin, available from 1990, decreased from 87% to 71%. Similar trends were observed when the susceptibilities of all gram-negative urinary pathogens were combined. The changes in susceptibility can probably be attributed to the empirical prescribing practices in the nursing homes studied.
authors.affiliation: Foundation Nursing Homes SVB, Kerkrade, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Vromen
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Ven
authors.forename: A
authors.initials: A
authors.lastname: Knols
authors.forename: E E
authors.initials: EE
authors.lastname: Stobberingh
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology; D003625:Data Collection; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009426:Netherlands; D009582:Nitrofurantoin / Q000494:pharmacology; D009735:Nursing Homes; D014552:Urinary Tract Infections / Q000382:microbiology*; D014556:Urine / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin