title: In vivo effects of 2-substituted [Mpa1Sar7Arg8]-oxytocin antagonists on postpartum rat.
abstract: A set of oxytocin antagonists consisting of [Mpa1Sar7Arg8]-oxytocin substituted by various conformationally restricted or bulky D amino acids at position 2 were synthetized and biologically tested. In in vivo pharmacological investigations, the effects of these peptides were examined on the spontaneous motor activity of postpartum rat. Three of the newly prepared peptides proved at least as effective in inhibiting uterine contractions as clinically investigated atosiban.
authors.affiliation: Department of Pharmacodynamics, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: I
authors.initials: I
authors.lastname: Zupkó
authors.forename: G K
authors.initials: GK
authors.lastname: Tóth
authors.forename: K
authors.initials: K
authors.lastname: Bakos
authors.forename: F
authors.initials: F
authors.lastname: Fülöp
authors.forename: I
authors.initials: I
authors.lastname: Pávó
authors.forename: J
authors.initials: J
authors.lastname: Havass
authors.forename: G
authors.initials: G
authors.lastname: Falkay
mesh_terms: D000818:Animals; D005260:Female; D010121:Oxytocin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D049590:Postpartum Period; D051381:Rats; D017207:Rats, Sprague-Dawley; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D010121:Oxytocin