Spontaneous resolution rate of grade 1 cervical intraepithelial neoplasia in a private practice population.
OBJECTIVE
The purpose of this study was to assess the rate of spontaneous resolution of grade 1 cervical intraepithelial neoplasia in a private practice patient population.


METHODS
One hundred consecutive women with biopsy-proven grade 1 cervical intraepithelial neoplasia were offered expectant management in the form of repeat Papanicolaou smears every 3 months up to 1 year or treatment. Women with inadequate colposcopic examination, positive endocervical sampling, or discordant Papanicolaou smears were excluded.


RESULTS
Eighty-nine (89%) women agreed to undergo expectant management. Of these, 67 (75.3%) experienced spontaneous resolution of lesions on the basis of 2 subsequent and consecutive normal smears corroborated by colposcopy. The median time to resolution was 9 months (n = 38). Seventeen (19.9%) women were treated at 1 year for persistent atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions by loop electrosurgical conization. Of these, 1 (1.1%) had a more advanced lesion (grade 2 cervical intraepithelial neoplasia). Four (4.5%) had progression before 1 year and were treated. Only 1 (1.1%) patient was lost to follow-up.


CONCLUSIONS
Expectant management of grade 1 cervical intraepithelial neoplasia is safe and cost-effective in a reliable patient population.
Falls
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D000328:Adult; D003127:Colposcopy; D019092:Conization; D004598:Electrosurgery; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D012075:Remission, Spontaneous; D013997:Time Factors; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000628:therapy*