Involvement of Fas/FasL system in the pathogenesis of autoimmune diseases and Wilson's disease.
The interaction of Fas with FasL has been demonstrated to be implicated in the pathogenesis of several autoimmune and liver diseases. Recently, attention has been focused on the hypothesis that thyrocytes and beta cells undergo massive Fas/FasL-mediated apoptosis during autoimmune response. Similarly, hepatocyte cell death occurring following copper accumulation points towards the same mechanism.
Stassi
G
G
Department of Surgical, Anatomical and Oncological Sciences, University of Palermo, Italy.
Di Felice
V
V
Todaro
M
M
Cappello
F
F
Zummo
G
G
Farina
F
F
Trucco
M
M
De Maria
R
R
D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D053222:Fas Ligand Protein; D006527:Hepatolenticular Degeneration / Q000209:etiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D013967:Thyroiditis, Autoimmune / Q000209:etiology*; D019014:fas Receptor / Q000502:physiology*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor