title: Dose distributions using kilovoltage x-rays and dose enhancement from iodine contrast agents.
abstract: In x-ray phototherapy of brain tumours, the tumour is loaded with iodine and exposed to kilovoltage x-rays. Due to the high photoelectric cross sections of iodine, substantial photoelectric interactions occur. The flux of photoelectrons, characteristic x-rays and Auger electrons produce a localized dose enhancement. A modified computed tomography scanner, CTRx, can be used both for tumour localization and delivery of the dose enhancement therapy. Monte Carlo methods were employed to simulate the treatment of iodinated brain tumours with a CTRx. The calculated results reveal the effect of tumour iodine concentration on dose distribution, the degree of skull bone sparing with the application of multiple arcs, and the homogeneity of tumour dose distribution versus iodine concentration. A comparison with 10 MV stereotactic radiosurgery treatment shows the potential of CTRx treatment relative to conventional treatment modalities.
authors.affiliation: Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles 90095, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Mesa
authors.forename: A
authors.initials: A
authors.lastname: Norman
authors.forename: T D
authors.initials: TD
authors.lastname: Solberg
authors.forename: J J
authors.initials: JJ
authors.lastname: Demarco
authors.forename: J B
authors.initials: JB
authors.lastname: Smathers
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000532:radiotherapy* / Q000601:surgery; D003287:Contrast Media / Q000627:therapeutic use*; D006801:Humans; D007455:Iodine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008959:Models, Neurological; D015233:Models, Statistical; D009010:Monte Carlo Method; D011829:Radiation Dosage; D016634:Radiosurgery; D012886:Skull / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007455:Iodine