title: [The hemolytic-uremic syndrome].
abstract: The microangiopathic thrombotic syndromes--thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS)--are characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal dysfunction, fever and central nervous system abnormalities. Today they are considered as two extremes of a continuous spectrum named TTP--HUS. The syndrome is an uncommon disease with a high mortality rate, despite treatment. The authors describe a case of hemolytic uremic syndrome in a young adult patient. Initially the clinical course and the first biopsy suggested a favourable prognosis, but the early recurrence with severe hypertension was followed by a fatal outcome 6 months later. Concerning this clinical case, the authors present a review of the most recent aspects of the pathogenesis and treatment of this syndrome.
authors.affiliation: Serviço de Medicina, Hospital Curry Cabral, Lisboa.
authors.forename: P A
authors.initials: PA
authors.lastname: Rodrigues
authors.forename: J
authors.initials: J
authors.lastname: Machado
authors.forename: O
authors.initials: O
authors.lastname: Cardoso
authors.forename: J
authors.initials: J
authors.lastname: Cruz
authors.forename: F
authors.initials: F
authors.lastname: Carvalho
authors.forename: M
authors.initials: M
authors.lastname: da Costa
authors.forename: R
authors.initials: R
authors.lastname: Proença
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D013997:Time Factors