title: Myelodysplastic syndrome in a patient with adult T-cell leukaemia.
abstract: A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described. The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t-MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13). Although monoclonal integration of human T lymphotropic virus type I (HTLV-I) proviral DNA was detected in the peripheral blood lymphocytes at ATL diagnosis, bone marrow cells at t-MDS diagnosis did not show monoclonal integration of HTLV-I. To our knowledge, this is the first report of t-MDS associated with ATL.
authors.affiliation: Department of Haematology, Imamura Bun-in Hospital, Kagoshima.
authors.forename: H
authors.initials: H
authors.lastname: Kawabata
authors.forename: A
authors.initials: A
authors.lastname: Utsunomiya
authors.forename: S
authors.initials: S
authors.lastname: Hanada
authors.forename: T
authors.initials: T
authors.lastname: Makino
authors.forename: Y
authors.initials: Y
authors.lastname: Takatsuka
authors.forename: S
authors.initials: S
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Suzumiya
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: S
authors.initials: S
authors.lastname: Horiike
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015139:Blotting, Southern; D004279:DNA, Viral / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D004279:DNA, Viral