title: Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA-5b incompatibility.
abstract: We report out experience in the perinatal management of a complex case of fetal hemolytic disease primarily due to Rhesus incompatibility combined with fetal alloimmune thrombocytopenia. The lowest fetal hemoglobin and platelet levels were 2.6 g/dl and 13,000/microliter, respectively. Intrauterine treatment consisted of six transfusions of packed red cells into the umbilical vein and one transfusion of platelets. The neonate required four transfusions of packed red cells to correct her hyporegenerative erythropoiesis. Postnatal management also included one platelet transfusion, intravenous immunoglobulins and erythropoietin. Although some degree of fetal thrombocytopenia may invariably be found in fetal red cell incompatibility, other rare causes need to be excluded.
authors.affiliation: Department of Fetal Diagnosis and Therapy, University Hospital, Bonn, Germany.
authors.forename: R L
authors.initials: RL
authors.lastname: Schild
authors.forename: J
authors.initials: J
authors.lastname: Hoch
authors.forename: H
authors.initials: H
authors.lastname: Plath
authors.forename: C
authors.initials: C
authors.lastname: Geissen
authors.forename: H
authors.initials: H
authors.lastname: Fahnenstich
authors.forename: C
authors.initials: C
authors.lastname: Dame
authors.forename: M
authors.initials: M
authors.lastname: Hansmann
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D001803:Blood Transfusion; D001805:Blood Transfusion, Intrauterine; D000939:Epitopes / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000150:complications / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000150:complications / Q000276:immunology / Q000628:therapy*; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology / Q000628:therapy*
chemical_list: C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D000939:Epitopes