Effect of bradykinin and its antagonist on survival time after coronary artery occlusion in rats.
The present study was conducted to examine the effect of bradykinin and bradykinin 2 receptor antagonist on survival time in rats with coronary artery ligation for 15 min and continuously. We also evaluated the heart rate and blood pressure responses in the presence and absence of bradykinin and its antagonist. Bradykinin treatment (4 microg and 8 microg/kg IV) significantly (p < 0.05) increased the survival time of rats compared with saline-treated rats with coronary artery ligation for 15 min and continuously. The heart rate and blood pressure responses were significantly (p < 0.001) altered in the presence of coronary artery ligation. Bradykinin antagonist treatment (4 microg/kg IV) abolished the effect of bradykinin and thus reduced the survival time of rats with coronary artery ligation. The mean value of survival time between saline-treated and bradykinin antagonist- plus bradykinin-treated rats did not differ significantly (p > 0.05).
Atif Abbas
S
S
Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang.
Sharma
J N
JN
Pauzi
A
A
Yusof
M
M
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives / Q000494:pharmacology*; D065168:Bradykinin Receptor Antagonists; D003331:Coronary Vessels / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate / Q000187:drug effects; D008026:Ligation; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D016019:Survival Analysis; D013997:Time Factors
D065168:Bradykinin Receptor Antagonists; D001920:Bradykinin