title: Risk factors associated with the failure of a venous leg ulcer to heal.
abstract: BACKGROUND
  Venous leg ulcers afflict a significant portion of the population. The most popular form of therapy for venous leg ulcers is a compression bandage (eg, Unna boot), a therapy that is frequently unsuccessful.
  
  
  OBJECTIVE
  To describe risk factors associated with the failure of a wound to heal when treated with a limb-compression bandage for 24 weeks.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Single-center outpatient specialty clinic at an academic medical center.
  
  
  METHODS
  Two hundred sixty consecutive patients with chronic venous leg ulcers.
  
  
  METHODS
  The magnitude of the effect of a given risk factor on the probability that a wound will heal within 24 weeks of care.
  
  
  RESULTS
  Based on an assessment of leg wounds during initial office visits, we observed that the failure of a wound to heal within 24 weeks was significantly associated with larger wound area, measured in square centimeters (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.11-1.27), duration of the wound in months (OR, 1.09; 95% CI, 1.04-1.16), history of venous ligation or venous stripping (OR, 4.58; 95% CI, 1.84-11.36), history of hip or knee replacement surgery (OR, 3.52; 95% CI, 1.12-11.08), ankle brachial index of less than 0.80 (OR, 3.52; 95% CI, 1.12-11.08), and the presence of fibrin on more than 50% of the wound surface (OR, 3.42; 95% CI, 1.38-8.45).
  
  
  CONCLUSIONS
  Several risk factors are associated with the failure of a patient's venous leg ulcer to heal while using limb-compression therapy. It is prudent to consider these factors when referring a patient to a wound care subspecialists or for alternative therapies.
authors.affiliation: Department of Dermatology, Center for Clinical Epidemiology, and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA. dmargoli@cceb.med.upenn.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Margolis
authors.forename: J A
authors.initials: JA
authors.lastname: Berlin
authors.forename: B L
authors.initials: BL
authors.lastname: Strom
mesh_terms: D000368:Aged; D001458:Bandages; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D017211:Treatment Failure; D014945:Wound Healing