Parvovirus glomerulonephritis in a patient with sickle cell disease.
A child with sickle cell disease developed glomerulonephritis 10 days following an aplastic crisis induced by human parvovirus B 19 infection. An initial kidney biopsy showed focal proliferative glomerulonephritis, and 1 year later was compatible with focal and segmental glomerulosclerosis. Renal tissue, tested by polymerase chain reaction, was positive for parvovirus, while the patient's blood was negative. For the first time a direct relationship has been demonstrated between parvovirus infection and glomerulonephritis.
Tolaymat
A
A
Nemours Children's Clinic and University of Florida/Jacksonville, 32207, USA.
Al Mousily
F
F
MacWilliam
K
K
Lammert
N
N
Freeman
B
B
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D005921:Glomerulonephritis / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000503:physiopathology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*