Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.
This investigation is devoted to design of short "switch" oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5'- and/or 3'-terminal positions or one of the pyrimidine heterocyclic bases are developed.
Gottikh
M B
MB
A.N. Belozersky Institute of Physical Chemical Biology, Lomonosov Moscow State University, Russia.
Volkov
E M
EM
Romanova
E A
EA
Oretskaya
T S
TS
Shabarova
Z A
ZA
D001483:Base Sequence; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics*; D007364:Intercalating Agents / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D016662:Virus Integration / Q000187:drug effects*
D019428:HIV Integrase Inhibitors; D007364:Intercalating Agents; D009841:Oligonucleotides