Protein folding in a specialized compartment: the endoplasmic reticulum.
The endoplasmic reticulum ensures proper folding of secretory proteins. In this review, we summarize and discuss the functions of different classes of folding mediators in the secretory pathway and propose updated models of the quality control system.
Zapun
A
A
Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada.
Jakob
C A
CA
Thomas
D Y
DY
Bergeron
J J
JJ
D000818:Animals; D002451:Cell Compartmentation; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D037102:Lectins / Q000378:metabolism; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D019704:Protein Disulfide-Isomerases / Q000378:metabolism; D017510:Protein Folding
D006023:Glycoproteins; D037102:Lectins; D019696:Peptidylprolyl Isomerase; D019704:Protein Disulfide-Isomerases