Relation between two independent DNA-repair pathways in different groups of naevi.
The relation between 2 DNA-repair systems was investigated in 3 groups of naevi (naevus cell naevi, dysplastic naevi, fibromatous naevi) using the correlation coefficient according to Spearman. In the group of naevus cell naevi, only 1 significant correlation between MSH2 and GADD34 expression was found. In the group of dysplastic naevi, 9 significant and highly significant correlations between GADD genes and mismatch repair genes were found. In the group of fibromatous naevi, MLH1 correlated significantly with GADD45 and highly significant with GADD34 expression. Different correlations in naevi groups investigated show the different functional connections between the genes of DNA repair.
Korabiowska
M
M
Department of Cytopathology, Georg-August University, Göttingen, Germany.
Brinck
U
U
Kellner
S
S
Droese
M
M
Berger
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000943:Antigens, Differentiation; D018797:Cell Cycle Proteins; D002648:Child; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein; D009506:Nevus / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014176:Protein Biosynthesis; D054645:Protein Phosphatase 1; D011506:Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism
D000943:Antigens, Differentiation; D018797:Cell Cycle Proteins; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; C087519:PPP1R15A protein, human; D054645:Protein Phosphatase 1; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein