[The role of nitrogen oxide in migraine attack].
Views are surveyed on the role of nitrogen oxide in the pathogenesis of migraine attacks. There is some evidence that molecule plays an important role in these attacks through vasodilation in the central nervous system. In the process of nitrogen oxide release glutaminergic receptors of NMDA type participate modulating the activity of serotoninergic receptors. Increased synthesis of nitrogen oxide can follow spreading cortical ischaemia, histamine release from mast cells in the meninges and also through activation of the trigeminovascular system. The hypothesis of active role of NO in the pathogenesis of migraine attacks is supported by the analysis of the mechanism of action of drugs effective in the treatment of that disease.
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Kliniki Neurologicznej Wojskowego Instytutu Medycyny Lotniczej w Warszawie.
D006152:Cyclic GMP / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000096:biosynthesis*; D011433:Propranolol / Q000627:therapeutic use*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D017661:Receptors, Presynaptic; D012701:Serotonin / Q000378:metabolism; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004791:Enzyme Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate; D017661:Receptors, Presynaptic; D014665:Vasodilator Agents; D009569:Nitric Oxide; D012701:Serotonin; D011433:Propranolol; D006152:Cyclic GMP; D019331:NG-Nitroarginine Methyl Ester