Plasma amyloid beta-peptide 1-42 and incipient Alzheimer's disease.
Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.
Mayeux
R
R
Taub Alzheimer's Disease Research Center, Staten Island, NY, USA.
Tang
M X
MX
Jacobs
D M
DM
Manly
J
J
Bell
K
K
Merchant
C
C
Small
S A
SA
Stern
Y
Y
Wisniewski
H M
HM
Mehta
P D
PD
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood*; D016229:Amyloid beta-Peptides / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010446:Peptide Fragments / Q000097:blood*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C098994:amyloid beta-protein (1-43)