title: Antisense effects of oligonucleotides complementary to the hairpin of the Leishmania mini-exon RNA.
abstract: We investigated the binding and the translation inhibitory properties of hexadecamers complementary to the mini-exon sequence of the protozoan parasite Leishmania amazonensis. This targeted RNA region folds into a hairpin. Large differences were observed in the antisense properties of the different oligomers although their binding to RNA always requires the disruption of the stem region.
authors.affiliation: INSERM U 386, IFR Pathologies Infectieuses, Université Victor Segalen, Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Compagno
authors.forename: J J
authors.initials: JJ
authors.lastname: Toulmé
mesh_terms: D000818:Animals; D001483:Base Sequence; D005091:Exons; D007891:Leishmania / Q000187:drug effects* / Q000235:genetics; D009690:Nucleic Acid Conformation; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D016053:RNA, Protozoan / Q000737:chemistry*
chemical_list: D016376:Oligonucleotides, Antisense; D016053:RNA, Protozoan