title: Is the lack of concurrence of bacterial vaginosis and vaginal candidosis explained by the presence of bacterial amines?
abstract: OBJECTIVE
  We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine.
  
  
  RESULTS
  Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie, C glabrata, C krusei, and C tropicalis).
  
  
  CONCLUSIONS
  We hypothesize that the presence of these and possibly other bacterial amines produced by anaerobes in the vaginal flora and seen in bacterial vaginosis, as in the healthy gut, may explain why candidosis is rarely seen in these instances.
authors.affiliation: Department of Microbiology, University of Oporto School of Medicine, Portugal.
authors.forename: A G
authors.initials: AG
authors.lastname: Rodrigues
authors.forename: P A
authors.initials: PA
authors.lastname: Mârdh
authors.forename: C
authors.initials: C
authors.lastname: Pina-Vaz
authors.forename: J
authors.initials: J
authors.lastname: Martinez-de-Oliveira
authors.forename: A F
authors.initials: AF
authors.lastname: da Fonseca
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D002103:Cadaverine / Q000378:metabolism* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002181:Candidiasis, Vulvovaginal / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D011700:Putrescine / Q000378:metabolism* / Q000494:pharmacology; D014621:Vagina / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000378:metabolism*
chemical_list: D002103:Cadaverine; D011700:Putrescine