title: Acute hypermagnesemia and respiratory arrest following infusion of MgSO4 for tocolysis.
abstract: Hypermagnesemia (6.95 mmol/l) and respiratory arrest occurred to a 20-year-old female (G3P2002) at 26 weeks of gestation during tocolytic treatment with MgSO4.7H2O (density greater than plasmalyte) injected into an i.v. infusion bag containing 1 l of plasmalyte without mixing. The patient was rescued with calcium gluconate and normal pregnancy continued. It is important to adequately mix an i.v. solution after adding a drug particularly when the drug-containing solution has greater density than the parent i.v. solution.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Louisville Hospital, KY 40292, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Cao
authors.forename: R
authors.initials: R
authors.lastname: Bideau
authors.forename: R
authors.initials: R
authors.lastname: Valdes
authors.forename: R J
authors.initials: RJ
authors.lastname: Elin
mesh_terms: D000328:Adult; D002125:Calcium Gluconate / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000097:blood* / Q000506:poisoning; D011041:Poisoning / Q000188:drug therapy; D011247:Pregnancy; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000188:drug therapy; D015149:Tocolytic Agents / Q000009:adverse effects*
chemical_list: D015149:Tocolytic Agents; D008278:Magnesium Sulfate; D002125:Calcium Gluconate