Clinical remission of xeroderma pigmentosum-associated squamous cell carcinoma with isotretinoin and chemotherapy: case report.
We report the case of a 7-year old boy with xeroderma pigmentosum and a large squamous cell carcinoma of the cheek. He received a combination of isotretinoin (1 mg/kg/day) and chemotherapy for a period of 3 months and showed complete remission of the tumor. Treatment modalities of malignancies in xeroderma pigmentosum are reviewed and discussed in relation to the literature. The advantages of our protocol were emphasized because of the rapid improvement in a short time with minimal side effects.
Saade
M
M
Division of Hematology-Oncology, Lebanese University Medical School, Beirut. yarasade@dm.net.lb
Debahy
N E
NE
Houjeily
S
S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000494:pharmacology / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014983:Xeroderma Pigmentosum / Q000188:drug therapy* / Q000473:pathology
D007641:Keratolytic Agents; D015474:Isotretinoin; D002945:Cisplatin; D005472:Fluorouracil