title: The interaction between RTX toxins and target cells.
abstract: RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell types, and the leukotoxins, which are cell-type- and species-specific. These toxins offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.
authors.affiliation: Leon Levy Research Center for Oral Biology, School of medicine, University of Pennsylvania, Philadelphia, PA 19104-6002, USA. lally@toxin.dental.upenn.edu
authors.forename: E T
authors.initials: ET
authors.lastname: Lally
authors.forename: R B
authors.initials: RB
authors.lastname: Hill
authors.forename: I R
authors.initials: IR
authors.lastname: Kieba
authors.forename: J
authors.initials: J
authors.lastname: Korostoff
mesh_terms: D000818:Animals; D017209:Apoptosis; D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D002462:Cell Membrane / Q000378:metabolism*; D003603:Cytotoxins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D005098:Exotoxins / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D006801:Humans; D009336:Necrosis
chemical_list: D001427:Bacterial Toxins; D003603:Cytotoxins; D005098:Exotoxins; D006460:Hemolysin Proteins; C018579:leukotoxin