Response to HBV vaccine in relation to anti-HCV and anti-HBc positivity: a study in intravenous drug addicts.
Drug addicts represent the group of young adults with the lowest response to hepatitis B virus (HBV) vaccine. A study was carried out on 110 current intravenous heroin users attending the service providing assistance to intravenous drug users (IVDUs) (SERT) in Padua: 66.4% of them were found anti-hepatitis C virus (HCV)-positive and 33.6% were anti-HBc positive; 29.9% were positive for both. The subjects were vaccinated with 10 microg of yeast-derived vaccine at months 0, 1 and 2 (fast schedule). The overall response rate was 66.4%. Response seems to be affected by positivity to anti-HBc, but not to HCV infection.
Minniti
F
F
Department of Gastroenterology, University of Padua, Italy.
Baldo
V
V
Trivello
R
R
Bricolo
R
R
Di Furia
L
L
Renzulli
G
G
Chiaramonte
M
M
D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000096:biosynthesis* / Q000097:blood; D003932:Heroin; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000097:blood / Q000276:immunology* / Q000821:virology
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D017325:Hepatitis B Vaccines; D018937:Hepatitis C Antibodies; D003932:Heroin