[The determination of clozapine in blood and urine by gas chromatography-mass spectrometry].
A method for measuring closapine in the blood and urine by gas chromatography-mass spectrometry as a trifluoroacetic derivative is proposed. The threshold level for closapine detection is 25 ng/ml in the blood and 30 ng/ml in the urine. Calibration curves are linear in the range 0.025-5 mcg/ml for the blood and 0.03-50 mcg/ml for the urine. The method can be used in forensic chemical and clinical toxicological analysis.
Melent'ev
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AB
Kurochkina
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IV
D014150:Antipsychotic Agents / Q000032:analysis* / Q000302:isolation & purification; D001826:Body Fluids / Q000737:chemistry*; D002138:Calibration; D003024:Clozapine / Q000032:analysis* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans
D014150:Antipsychotic Agents; D003024:Clozapine