title: Leukotriene modifiers in the management of asthma.
abstract: Leukotrienes play a major role in the underlying pathophysiology of asthma. Leukotriene-receptor antagonists and direct leukotriene-synthesis inhibitors may be important new agents in maintenance therapy for asthma. Their role may also extend to attenuating exercise-induced and allergen-induced bronchospasm. This article reviews the effectiveness of available leukotriene modifiers in various clinical studies, reviews their adverse effects profile, and discusses their potential roles in the management of asthma.
authors.affiliation: Department of Pharmacy Services, Detroit Medical Center, Detroit Receiving Hospital, MI 48201, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Elnabtity
authors.forename: R F
authors.initials: RF
authors.lastname: Singh
authors.forename: M A
authors.initials: MA
authors.lastname: Ansong
authors.forename: T J
authors.initials: TJ
authors.lastname: Craig
mesh_terms: D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*
chemical_list: D020024:Leukotriene Antagonists