[Beneficial effect and mechanism of 764-3 on cognitive deficit induced by brain damage in rats].
Animal model of excitotoxic cognitive deficit induced by kainic acid bilaterally injection into caudate nucleus was successfully established in rats. Based on this model, chronic administration of 764-3 (8 mg/(kg.d), i.p.), an extract from Chinese traditional medicine, markedly improved the learning and memory impairment in the injured caudate nucleus rats. Moreover, attenuation of the neuronal loss in caudate nucleus following excitotoxic damage was observed after 764-3 treatment. In addition, results indicated that the mechanism of the effect of 764-3 may be related to the antagonism against the decline of Na(+)-K(+)-ATPase and Ca(2+)-Mg(2+)-ATPase activity in synaptic membrane resulted from excitotoxicity.
Qiao
M
M
Institute of Basic Medical Sciences, CAMS, Beijing.
Zhang
S
S
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced*; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy* / Q000201:enzymology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007608:Kainic Acid; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D007608:Kainic Acid