[The evaluation of galanin, gonadotropin and estradiol levels in girls with simple weight loss due to amenorrhea].
Pathophysiology of weight loss related amenorrhea is not fully understood. Disturbances in GnRH pulsatility play a key role in this state. There is a group of neuropeptides (CRH, TRH) which inhibit GnRH secretion and also neuropeptides (galanin, Neuropeptide Y) which can stimulate GnRH release. Therefore the aim of study was to evaluate the serum galanin, FSH, LH, estradiol levels in young women with secondary amenorrhea after weight loss and in normal women Serum galanin, FSH, LH, estradiol levels were measured with the use of radioimmunoassay methods. There was no significant difference in serum galanin levels between amenorrheic women and control. FSH, LH and estradiol levels in amenorrheic women were significantly lower than in control. We conclude that serum galanin levels appear to be comparable in amenorrheic and normal women.
Meczekalski
B
B
Katedry i Kliniki Endokrynologii Ginekologicznej Akademii Medycznej w Poznaniu.
Warenik-Szymankiewicz
A
A
Halerz-Nowakowska
B
B
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000175:diagnosis / Q000523:psychology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D019004:Galanin / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015431:Weight Loss
D004958:Estradiol; D019004:Galanin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone