New insights into the in vivo function of heterotrimeric G-proteins through gene deletion studies.
A huge number of receptors signals through heterotrimeric G-proteins to regulate a wide variety of physiological processes. The ability to modify G-protein expression in vivo provides a powerful new tool to analyze the function of G-protein-mediated signalling pathways. Genetic ablation of G-protein alpha-subunit genes is continuing to give new insights into the physiological roles of heterotrimeric G-proteins. This review highlights recent advances resulting from such genetic approaches to the study of G-protein-mediated signalling.
Offermanns
S
S
Institut für Pharmakologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany. stoff@zedat.fu-berlin.de
D000818:Animals; D001259:Ataxia / Q000097:blood / Q000235:genetics; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002531:Cerebellum / Q000503:physiopathology; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000502:physiology; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D017353:Gene Deletion; D018628:Gene Dosage; D051379:Mice; D008817:Mice, Mutant Strains; D015539:Platelet Activation; D015398:Signal Transduction / Q000502:physiology*
D019204:GTP-Binding Proteins; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D019205:GTP-Binding Protein alpha Subunits, Gs