Synthesis of 1-(2-aminophenyl)isoquinolines and the biological activity of their cis-dichloro platinum(II) complexes.
The broad biological effects of isoquinolines prompted us to use them as chelating, nonleaving ligands in cis-platinum(II) antitumor complexes. The synthesis of several 1-(2-aminophenyl)isoquinoline derivatives with different levels of hydrogenation and varying substitution of the phenyl ring is reported. These compounds constitute a new class of ligands for the synthesis of oligocyclic platinum(II) complexes. In vitro cytotoxicity tests indicate that the most basic amine ligands afford the most effective complexes. Two of the new complexes were more potent against L1210 murine leukemia cells than the well-established antitumor compound cisplatinum.
von Nussbaum
F
F
Institut für Organische Chemie der Universität München, Butenandtstrasse 5-13, D-81377 München, Germany.
Miller
B
B
Wild
S
S
Hilger
C S
CS
Schumann
S
S
Zorbas
H
H
Beck
W
W
Steglich
W
W
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D002455:Cell Division / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007546:Isoquinolines; D017671:Platinum Compounds