Possible mechanism of action of vanadium ions as an antidiabetic agent.
Vanadium compounds, at much higher concentrations than they are typically ingested, are being considered for use in the treatment of diabetes mellitus. They exert an insulin-mimetic effect in an insulin-receptor-independent manner. In our study we obtained new data about the vanadium insulin-receptor-independent mechanism of action on cell membranes. When rat stomach smooth muscle samples are treated with NH4VO3 (10(-7) divided by 10(-5) this action is possibly exhibited with increased influx of Ca2+ through VDCa2+C.
Terziyski
K
K
Department of Physiology and Biophysics, Higher Medical Institute, Plovdiv.
Tzenova
R
R
Milieva
E
E
Vladeva
S
S
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism; D015398:Signal Transduction; D014639:Vanadium / Q000494:pharmacology* / Q000627:therapeutic use
D014639:Vanadium; D011972:Receptor, Insulin; D002118:Calcium