title: Lack of association between Helicobacter pylori infection and extracardiac atherosclerosis in dyspeptic elderly subjects.
abstract: BACKGROUND
  There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases.
  
  
  OBJECTIVE
  To determine if there is an association between gastric HP infection and atherosclerosis of cerebral or peripheral arteries in elderly subjects.
  
  
  METHODS
  90 dyspeptic elderly subjects had upper gastro-intestinal endoscopy and the gastroduodenal pathology was identified. HP infection was confirmed by gastric histology and the rapid urease test. Vascular ultrasonography of extracranial cerebral arteries and leg arteries was performed to evaluate (i) the presence of an atherosclerotic lesion, (ii) the total length of all plaques documented and (iii) the number of arteries with atherosclerotic lesions. Statistical analysis was by the chi2 test, Yates's corrected chi2 test, the Mann-Whitney test and logistic regression.
  
  
  RESULTS
  59 subjects were HP-positive. These had a higher prevalence of peptic ulcer disease (P = 0.01) and higher serum levels of IgG anti-HP antibodies (P = 0.0001), but no significant differences in the number of atherosclerotic lesions, the total length of the plaques or the number of arteries with lesions. No significant association of HP positivity was found with diabetes mellitus, hypertension, cigarette smoking or coronary heart disease, nor with serum concentrations of HDL-cholesterol, fibrinogen, triglycerides or glucose.
  
  
  CONCLUSIONS
  Elderly dyspeptic subjects with gastric HP infection had significantly more peptic ulcer disease but no more atherosclerotic lesions than those who were HP-negative. Atherosclerosis was not associated with HP infection. In this cross-sectional study of elderly patients with dyspepsia, no association between HP infection and extracardiac atherosclerosis was found.
authors.affiliation: Division of Geriatric Medicine, S. Bortolo Hospital, Vicenza, Italy. pilotto@mbox.avnet.it
authors.forename: A
authors.initials: A
authors.lastname: Pilotto
authors.forename: F
authors.initials: F
authors.lastname: Rumor
authors.forename: M
authors.initials: M
authors.lastname: Franceschi
authors.forename: G
authors.initials: G
authors.lastname: Leandro
authors.forename: R
authors.initials: R
authors.lastname: Novello
authors.forename: G
authors.initials: G
authors.lastname: Soffiati
authors.forename: M
authors.initials: M
authors.lastname: Scagnelli
authors.forename: F
authors.initials: F
authors.lastname: Di Mario
authors.forename: G
authors.initials: G
authors.lastname: Valerio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000150:complications / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D016480:Helicobacter pylori; D006801:Humans; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D013272:Stomach Diseases / Q000150:complications / Q000382:microbiology*; D016909:Tibial Arteries / Q000000981:diagnostic imaging; D014463:Ultrasonography