title: Cancer gene and immunotherapy: recent developments.
abstract: Gene and immunotherapeutic approaches to treat human malignant tumors are reviewed. Special attention is given to the different strategies of cancer gene therapy and to recent aspects of cytokine-supported tumor immunotherapy or tumor-specific vaccination. The limitations of these therapy approaches are critically discussed especially with respect to immune escape mechanisms.
authors.affiliation: Department of Research/Molecular Cancer Research, Kantonsspital, Basel, Switzerland. jantscheff@ubaclu.unibas.ch
authors.forename: P
authors.initials: P
authors.lastname: Jantscheff
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
authors.forename: C
authors.initials: C
authors.lastname: Rochlitz
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D016207:Cytokines / Q000627:therapeutic use; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D008545:Melanoma / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019139:Tumor Escape
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D016207:Cytokines