title: Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression.
abstract: Sleep deprivation is a potentially useful non-pharmacological treatment for depression. A relationship between sleep loss and the onset of mania has been reported, so it is possible that a switch from depression into mania after sleep deprivation might be expected in bipolar depressed patients who are treated with sleep deprivation. In a sample of 206 bipolar depressed treated with three cycles of sleep deprivation, alone or in combination with heterogeneous medications, we observed a 4.85% switch rate into mania and a 5.83% switch rate into hypomania. These percentages are comparable to those observed with antidepressant drug treatments.
authors.affiliation: IRCCS Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Colombo
authors.forename: F
authors.initials: F
authors.lastname: Benedetti
authors.forename: B
authors.initials: B
authors.lastname: Barbini
authors.forename: E
authors.initials: E
authors.lastname: Campori
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D003131:Combined Modality Therapy; D003863:Depression / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents