Genomic plasticity in natural populations of Bordetella pertussis.
We determined the genomic organization of 14 clinical strains of Bordetella pertussis isolated over an 18-month period in Alberta, Canada. The maps of these 14 strains, while demonstrating general similarity of gene order, display a number of examples of genomic rearrangements in the form of large chromosomal inversions.
Stibitz
S
S
Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. stibitz@helix.nih.gov
Yang
M S
MS
D001886:Bordetella pertussis / Q000235:genetics* / Q000302:isolation & purification; D002170:Canada / Q000453:epidemiology; D002876:Chromosomes, Bacterial; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D016680:Genome, Bacterial; D006801:Humans; D014917:Whooping Cough / Q000453:epidemiology / Q000382:microbiology