Lbx2, a novel murine homeobox gene related to the Drosophila ladybird genes is expressed in the developing urogenital system, eye and brain.
We describe the cloning, expression pattern, and genomic organization of Lbx2, a murine homologue of the Drosophila and mammalian ladybird genes. Lbx2 includes a homeodomain motif most closely related to those of Lbx1 and the Drosophila ladybird proteins. Lbx2 transcripts are first detected at E10.5 when they are located in the gonadal component of the urogenital ridge. Expression of Lbx2 dramatically increases by E11.5 in the urogenital ridges, and in the cranial surface ectoderm. At later stages, Lbx2 transcripts are expressed in the brain and organs derived from the urogenital ridge, including the gonadal tubercle, kidneys, and adrenal glands. From E14.5 to birth, Lbx2 expression is evident in the developing retinal neuroepithelium and the vibrissa.
Chen
F
F
Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Liu
K C
KC
Epstein
J A
JA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D005123:Eye / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics; D014566:Urogenital System / Q000196:embryology*
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C086967:Lbe protein, Drosophila; C491868:Lbx1h protein, mouse; C121637:Lbx2h protein, mouse; D009124:Muscle Proteins; D014157:Transcription Factors; C103969:lbl protein, Drosophila