Paraneoplastic limbic encephalitis associated with small cell carcinoma of the prostate.
A 76-year-old man with primary small cell carcinoma of the prostate died after a subacute illness marked by memory loss and truncal ataxia Post-mortem examination of the central nervous system was consistent with limbic encephalitis and cerebellar degeneration. Although limbic encephalitis is a known complication of small cell carcinoma of the lung, this seems to be the first reported case of limbic encephalitis associated with small cell carcinoma of the prostate. Implications with respect to diagnosis and therapy are discussed.
Stern
R C
RC
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Hulette
C M
CM
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism; D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000378:metabolism; D004660:Encephalitis / Q000175:diagnosis* / Q000378:metabolism; D017809:Fatal Outcome; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008032:Limbic System; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
D016708:Synaptophysin; D017430:Prostate-Specific Antigen