title: [Role of heat-shock proteins in cardioprotection of patients operated on for ischemic heart disease].
abstract: Major stress protein HSP72 is known to participate in protecting cells and organisms against harmful factors including ischemia, trauma etc. Under study was the level of HSP72 in the myocardium of 32 patients with coronary disease operated in Military-medical academy. HSP72 was detected in probes of the right atria before and after pre-cardiopulmonary bypass in all cases induction of HSP72 was observed in 40% of patients, and directly correlated with the time of cardiopulmonary bypass and standing of the disease. The cardioprotective effect of the elevated pre-operational level of HSP72 was shown to be proportionate to the lower activity of cardiospecific enzymes, creatine phosphokinase (CK-MB). It is suggested that HSP72 is involved in the mechanism of cardioprotection during cardiopulmonary bypass.
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Shevchenko
authors.forename: O N
authors.initials: ON
authors.lastname: Demidov
authors.forename: V V
authors.initials: VV
authors.lastname: Tyrenko
authors.forename: A S
authors.initials: AS
authors.lastname: Svistov
authors.forename: A B
authors.initials: AB
authors.lastname: Belevitin
authors.forename: A I
authors.initials: AI
authors.lastname: Karpishchenko
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Komarova
authors.forename: T V
authors.initials: TV
authors.lastname: Popova
authors.forename: A V
authors.initials: AV
authors.lastname: Kinev
authors.forename: B A
authors.initials: BA
authors.lastname: Margulis
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000601:surgery; D001706:Biopsy; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D003402:Creatine Kinase / Q000097:blood; D003627:Data Interpretation, Statistical; D004591:Electrophoresis, Polyacrylamide Gel; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology; D006360:Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
chemical_list: D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D003402:Creatine Kinase