title: Stenosis of the main artery supplying an organ: effect of end-organ vascular compliance on the poststenotic peak systolic velocity.
abstract: Prior studies have shown variable results using poststenotic peak systolic velocity to detect hemodynamically significant renal artery stenoses. We postulated that vascular compliance, which affects the arterial waveform and varies by a factor of at least 5 in vivo, affects the peak systolic velocity, perhaps explaining the aforementioned variable results using peak systolic velocity to detect stenoses. A hydraulic model was used to investigate the relationship between end-organ vascular compliance and the peak systolic velocity. The peak systolic velocity was found to be mildly dependent on vascular compliance, decreasing with decreasing compliance. These results help explain some of the reported variability using peak systolic velocity to detect hemodynamically significant renal artery stenoses, but the effect is not great enough to explain the variability completely. Other factors not investigated in this study must exist that also affect peak systolic velocity.
authors.affiliation: Department of Radiology, University of Michigan Meidcal Center, Ann Arbor 48109-0326, USA.
authors.forename: R O
authors.initials: RO
authors.lastname: Bude
authors.forename: J M
authors.initials: JM
authors.lastname: Rubin
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D004867:Equipment Design; D006439:Hemodynamics; D018056:Hemorheology; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D016014:Linear Models; D008953:Models, Anatomic; D011673:Pulsatile Flow / Q000502:physiology; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015203:Reproducibility of Results; D013599:Systole; D018608:Ultrasonography, Doppler; D018924:Vascular Capacitance / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology