title: Salvage therapy of refractory and relapsed acute leukemia with high dose mitoxantrone and high dose cytarabine.
abstract: We have assessed the outcome of 66 refractory and relapsed acute leukemia patients treated with high dose mitoxantrone and cytarabine. Therapy consisted of a total dose of 40-60 mg/m2 mitoxantrone and 3 g/m2 of cytarabine daily on 5 consecutive days. A total of 28 patients were treated for primary resistant and 38 patients for early or late relapsed leukemia. A total of 35 patients achieved CR. Four patients died during the induction course. Toxicity was acceptable and comparable to other salvage regimens. The median disease-free and overall survivals were 4 and 6 months, respectively. Although this regimen is effective in achieving remission in refractory leukemia, its duration is short.
authors.affiliation: Institute of Hematology, The Chain Sheba Medical Center, Tel-Hasomer, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Raanani
authors.forename: O
authors.initials: O
authors.lastname: Shpilberg
authors.forename: S
authors.initials: S
authors.lastname: Gillis
authors.forename: A
authors.initials: A
authors.lastname: Avigdor
authors.forename: I
authors.initials: I
authors.lastname: Hardan
authors.forename: M
authors.initials: M
authors.lastname: Berkowicz
authors.forename: O
authors.initials: O
authors.lastname: Sofer
authors.forename: I
authors.initials: I
authors.lastname: Lossos
authors.forename: A
authors.initials: A
authors.lastname: Chetrit
authors.forename: D
authors.initials: D
authors.lastname: Ben-Yehuda
authors.forename: I
authors.initials: I
authors.lastname: Ben-Bassat
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008942:Mitoxantrone / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012008:Recurrence; D012074:Remission Induction; D016879:Salvage Therapy; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D003561:Cytarabine; D008942:Mitoxantrone