The development of AIDS-associated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6.
B cell hyperactivation accompanies HIV infection and is believed to contribute to the increased incidence of B cell lymphoma in persons with AIDS. To examine B cell activation which precedes the development of AIDS-associated lymphoma, we measured levels of two B cell stimulatory molecules, soluble CD23 (sCD23) and interleukin 6 (IL6), in the serum of HIV-infected individuals prior to the diagnosis of lymphoma. Serum sCD23 was elevated in those subjects who developed lymphoma, compared to AIDS, HIV+, and HIV- controls (P = 0.001). Serum IL6 was significantly elevated in subjects who developed Burkitt's/small noncleaved cell lymphoma (BL/SNC, P = 0.01), but not in those subjects who developed large cell, immunoblastic, or central nervous system lymphomas, compared to CD4-matched AIDS controls who did not have lymphoma. These results suggest that lymphomagenesis of the BL/SNC subtype of AIDS lymphoma reflects B cell hyperactivation of a different nature from that which precedes other subtypes of AIDS-associated B cell lymphoma.
Breen
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EC
Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, California, 90095, USA.
van der Meijden
M
M
Cumberland
W
W
Kishimoto
T
T
Detels
R
R
Martínez-Maza
O
O
D015415:Biomarkers / Q000097:blood; D002051:Burkitt Lymphoma / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008223:Lymphoma / Q000209:etiology / Q000276:immunology; D016483:Lymphoma, AIDS-Related / Q000097:blood*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000276:immunology; D017455:Receptors, IgE / Q000097:blood; D012995:Solubility; D013997:Time Factors
D015415:Biomarkers; D015850:Interleukin-6; D017455:Receptors, IgE