p21-activated protein kinase: a crucial component of morphological signaling?
The mechanisms by which Rho family GTPases (Rho, Rac and Cdc42) regulate coordinated changes to the actin cytoskeleton are being elucidated. This review will focus on the current evidence that the p21-activated kinases (PAKs) are involved in regulating some of the diverse cytoskeletal changes induced by Rac and Cdc42. PAKs have been shown to be required for processes including neurite formation and axonal guidance, development of cell polarity and motile responses. Signaling molecules interacting with PAKs that might contribute to the regulation of such processes have recently been identified.
Daniels
R H
RH
Depts of Immunology and Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Bokoch
G M
GM
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D016764:Cell Polarity; D003599:Cytoskeleton / Q000378:metabolism*; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors; D054461:Lim Kinases; D009218:Myosins / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000378:metabolism*; D064067:Rho Guanine Nucleotide Exchange Factors; D015398:Signal Transduction / Q000502:physiology*; D020764:cdc42 GTP-Binding Protein; D054462:p21-Activated Kinases; D020741:rho GTP-Binding Proteins
D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D064067:Rho Guanine Nucleotide Exchange Factors; D011494:Protein Kinases; D054461:Lim Kinases; D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases; D019204:GTP-Binding Proteins; D009218:Myosins; D020764:cdc42 GTP-Binding Protein; D020741:rho GTP-Binding Proteins