Thermodynamic ionization constants of antihypertensive drugs.
The thermodynamic ionization constants (pKa) of indapamide, clonidine and methyldopa have been determined at 25 degrees C and 35 degrees C by pH titration technique. The pKa varies linearly with mole fraction of dioxane. The thermodynamic parameters have been calculated.
Agrawal
Y K
YK
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India.
Menon
S K
SK
Majumudar
F
F
Jain
V K
VK
D000465:Algorithms; D000959:Antihypertensive Agents / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D013816:Thermodynamics
D000959:Antihypertensive Agents