Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.
The present study was conducted to determine the carcinogenicity of dimethylarsinic acid (DMA) administered to male F344 rats in a 2 year bioassay. A total of 144 rats (10 weeks old at the start) were divided into four groups of 36 rats each. Groups 1-4 received DMA (purity 100%) at concentrations of 200, 50, 12.5 and 0 p.p.m. in the drinking water, respectively, for 104 weeks. From weeks 97 to 104, urinary bladder tumors were observed in 12 of 31, eight of 31 and none of 33 in groups 1-3, respectively. No bladder tumors were observed in group 4. The present study demonstrated that long-term p. o. administration of DMA induced urinary bladder carcinomas in male F344 rats. Therefore, the results indicate that DMA is carcinogenic for the rat urinary bladder, which may be related to the human carcinogenicity of arsenicals.
Wei
M
M
Department of Pathology, Osaka City University Medical School, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
Wanibuchi
H
H
Yamamoto
S
S
Li
W
W
Fukushima
S
S
D000284:Administration, Oral; D000818:Animals; D002101:Cacodylic Acid / Q000008:administration & dosage / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D051381:Rats; D011916:Rats, Inbred F344; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*; D019459:Urothelium / Q000187:drug effects / Q000473:pathology
D004785:Environmental Pollutants; D002101:Cacodylic Acid