title: Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices.
abstract: SH3 and WW domains are involved in a variety of intracellular signaling pathways. Recent work has shed light on the mechanism whereby these signaling modules recognize prolines in polyproline ligands, which has implications in the design of ligands selectively targeting these interactions.
authors.affiliation: Cellular Biochemistry & Biophysics Program, Memorial Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: B
authors.initials: B
authors.lastname: Aghazadeh
authors.forename: M K
authors.initials: MK
authors.lastname: Rosen
mesh_terms: D000478:Alkylation; D000818:Animals; D015252:Deoxyribonucleases, Type II Site-Specific / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains / Q000235:genetics*
chemical_list: D008024:Ligands; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases