The prognosis of stage A patients treated with the antiandrogen chlormadinone acetate.
To determine the efficacy of the antiandrogen chlormadinone acetate as a treatment option for stage A prostate cancer, a retrospective analysis of 111 patients who received chlormadinone acetate was done. Of 55 stage A1 patients, progression was seen in one patient (1.8%) 8 years after the diagnosis. Six out of 56 stage A2 patients (10.7%) showed disease progression at 1-7 years (mean 68 months) after the diagnosis. Progression rates associated with antiandrogen therapy for stage A1 and stage A2 patients were lower than those without treatment reported in the literature. It could be assumed that antiandrogen treatment with chlormadinone acetate inhibited the progression.
Kubota
Y
Y
Department of Urology, Yamagata University School of Medicine, Japan.
Nakada
T
T
Sasagawa
I
I
Yanai
H
H
Itoh
K
K
Suzuki
H
H
D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D002715:Chlormadinone Acetate / Q000627:therapeutic use*; D018450:Disease Progression; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D045167:Progesterone Congeners / Q000627:therapeutic use; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate
D000726:Androgen Antagonists; D045167:Progesterone Congeners; D002715:Chlormadinone Acetate