title: An overview of cyclophosphamide development and clinical applications.
abstract: In this overview of the pharmacology of the anticancer drug cyclophosphamide, a brief history of the development of this drug from the general class of nitrogen mustards is provided. The antitumor activity of cyclophosphamide and its isomer ifosfamide is discussed through considerations of metabolism, resistance, detoxification, and DNA cross-linking. Clinical uses in general chemotherapy, bone marrow transplantation and immunosuppression are presented. A review with 73 references.
authors.affiliation: Duke Comprehensive Cancer Center and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. colvi003@mc.duke.edu
authors.forename: O M
authors.initials: OM
authors.lastname: Colvin
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use*; D049673:History, 20th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide