Growth hormone response to oral glucose tolerance and insulin tolerance tests in patients with PCOS.
Polycystic ovary syndrome (PCOS) is characterized by its heterogeneity. This is the reason for the diversity in the clinical manifestations and laboratory findings. In this study we examined the serum levels of growth hormone (GH) in 15 women with PCOS and 5 healthy volunteers following oral administration of 75 gr glucose (OGTT) and intravenous administration of insulin (ITT). The OGTT produced no significant difference between the two groups of women, in the ITT there was a difference between the GH response of the women with PCOS and that of the healthy women. The group with PCOS showed a later, more prolonged, higher response, indicating that the hypothalamus is probably involved in PCOS.
Zournatzi
V
V
2nd Department of Obstetrics and Gynecology, Aristotelian University of Thessaloniki, Greece.
Koios
G
G
Vavilis
D
D
Saravelos
H
H
Tarlatzis
V
V
Bontis
J
J
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D007328:Insulin; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone