title: High prevalence of activated protein C resistance due to factor V leiden mutation in cases of intrauterine fetal death.
abstract: OBJECTIVE
  To test a possible association between activated protein C resistance and intrauterine fetal death.
  
  
  METHODS
  The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls.
  
  
  RESULTS
  Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P = 0.013).
  
  
  CONCLUSIONS
  Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.
authors.affiliation: Department of Obstetrics and Gynecology, Poriya Hospital, Tiberias, Israel.
authors.forename: H
authors.initials: H
authors.lastname: Rothbart
authors.forename: G
authors.initials: G
authors.lastname: Ohel
authors.forename: J
authors.initials: J
authors.lastname: Younis
authors.forename: N
authors.initials: N
authors.lastname: Lanir
authors.forename: B
authors.initials: B
authors.lastname: Brenner
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009154:Mutation
chemical_list: C095381:factor V Leiden; D005165:Factor V