Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers.
Polysomnography, blood concentration and core body temperature recordings were performed on 12 healthy volunteers with administration of trazodone and placebo. Trazodone increased slow wave sleep (SWS), and decreased the average, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with amplitude (the difference between the highest and lowest temperature) and %SWS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.
Yamadera
H
H
Department of Neuropsychiatry, Nippon Medical School Tokyo, Japan.
Suzuki
H
H
Nakamura
S
S
Endo
S
S
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000493:pharmacokinetics / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D017286:Polysomnography / Q000187:drug effects*; D016037:Single-Blind Method; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology; D014196:Trazodone / Q000493:pharmacokinetics / Q000494:pharmacology*
D018687:Antidepressive Agents, Second-Generation; D006993:Hypnotics and Sedatives; D014196:Trazodone