Immunocytochemical localisation of PTHrP (parathormone-related peptide) in myoepithelial cells of human sweat and parotid glands.
PTHrP is a HHM-inducing peptide. It exhibits certain structural similarity to PTH and the two hormones may act through the same receptors. PTHrP is known to be produced in various tissues as well as during development. In this study we decided to immunocytochemically demonstrate PTHrP in normal skin and squamous cell carcinomas as well as in parotid glands (normal, inflamed and neoplastic). In the skin, PTHrP expression was demonstrated in epidermis and in smooth muscle cell layer of blood vessels. In squamous cell carcinomas, the expression was noted in foci of keratinization. In parotid glands, the peptide was localised in excretory ducts and in blood vessels, while inflammation of the gland and its tumours resulted most frequently in the less intense immunoreaction. The results are consistent with those of other authors. The novel observations include demonstration of PTHrP expression in myoepithelial cells of sweat glands and in parotid glands, where it may be involved in the control of their contractile activity.
Zabel
M
M
Department of Histology and Embryology, University of Medicine, Wrocław, Poland.
Murawski
M
M
Surdyk-Zasada
J
J
Salwa-Zurawska
W
W
Radziemski
A
A
D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D004817:Epidermis / Q000378:metabolism; D004847:Epithelial Cells / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D009132:Muscles / Q000737:chemistry / Q000166:cytology*; D009363:Neoplasm Proteins / Q000032:analysis; D010281:Parathyroid Hormone / Q000032:analysis; D044162:Parathyroid Hormone-Related Protein; D010306:Parotid Gland / Q000166:cytology* / Q000378:metabolism; D010307:Parotid Neoplasms / Q000737:chemistry / Q000473:pathology; D011506:Proteins / Q000032:analysis*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology; D013545:Sweat Glands / Q000166:cytology* / Q000378:metabolism
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins