title: The role of HSP90 in evolution.
abstract: A mechanism by which morphological mutations are stored without expressing phenotypes was unraveled by Rutherford & Lindquist (1998) through genetic studies of Hsp83 (HSP90) in Drosophila. Cryptic mutations are essentially neutral and therefore evolve in the absence of selective constraint. A shift from neutral mutations to selective mutations is induced when flies are exposed to environmental stress. This is a step toward understanding macroevolution in molecular terms.
authors.affiliation: The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-ku, Tokyo 113-8613, Japan. yahara@rinshoken.or.jp
authors.forename: I
authors.initials: I
authors.lastname: Yahara
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D017344:Genes, Insect / Q000235:genetics / Q000502:physiology; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D012641:Selection, Genetic
chemical_list: D018841:HSP90 Heat-Shock Proteins