title: Administration of diminazene aceturate or imidocarb dipropionate for treatment of cytauxzoonosis in cats.
abstract: Bobcats (Lynx rufus) are the reservoir hosts for Cytauxzoon felis, the causative agent of cytauxzoonosis. Cytauxzoonosis is a highly fatal tickborne blood protozoal disease of domestic and exotic cats. Treatment of clinically affected cats has generally been unrewarding. In our report, 6 of 7 cats had signs of illness and laboratory findings indicative of cytauxzoonosis and were successfully treated with 2 i.m. injections of diminazene aceturate or imidocarb dipropionate (2 mg/kg [0.9 mg/lb] of body weight, each). One cat died after the first injection of diminazene. Additional treatment with isotonic fluids i.v. and heparin s.c. were used as supportive care for dehydration and disseminated intravascular coagulation that were detected by laboratory testing between diminazene or imidocarb treatments. Atropine was effective in recovery and preventing adverse reactions associated with imidocarb treatment of 1 cat.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Greene
authors.forename: K
authors.initials: K
authors.lastname: Latimer
authors.forename: E
authors.initials: E
authors.lastname: Hopper
authors.forename: G
authors.initials: G
authors.lastname: Shoeffler
authors.forename: K
authors.initials: K
authors.lastname: Lower
authors.forename: F
authors.initials: F
authors.lastname: Cullens
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001769:Blood / Q000469:parasitology; D001803:Blood Transfusion / Q000662:veterinary; D001831:Body Temperature; D002371:Cat Diseases / Q000188:drug therapy* / Q000469:parasitology; D002415:Cats; D004133:Diminazene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004906:Erythrocyte Count / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D006402:Hematologic Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D006493:Heparin / Q000627:therapeutic use; D007095:Imidocarb / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007273:Injections, Intramuscular / Q000662:veterinary; D007552:Isotonic Solutions / Q000627:therapeutic use; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D016792:Piroplasmida / Q000187:drug effects; D011528:Protozoan Infections / Q000188:drug therapy; D011529:Protozoan Infections, Animal; D016482:Urinalysis / Q000662:veterinary
chemical_list: D000981:Antiprotozoal Agents; D007552:Isotonic Solutions; D007095:Imidocarb; D006493:Heparin; C003915:diminazene aceturate; D004133:Diminazene; C031719:imidocarb dipropionate