title: [Penile carcinoma with humoral hypercalcemia of malignancy (HHM): a case report].
abstract: A 57-year-old male, with 1.5 cm tumor in his prepuce, was admitted to our institute in Feb. 1990. Circumcision and inguinal lymph node dissection was performed under the diagnosis of T1 disease of penile carcinoma. Pathological evaluation revealed well-differentiated squamous cell carcinoma (SCC). In April 1996, the patient revealed recurrence of the disease in the right inguinal lymph nodes and the lower abdomen, that was diagnosed to be poorly differentiated SCC. Laboratory findings showed elevation of serum calcium, parathyroid hormone-related protein (PTHrP) levels. Immunohistochemical staining confirmed production of PTHrP in the tumor tissue. This is the first case report of penile carcinoma that caused humoral hypercalcemia of malignancy in Japan.
authors.affiliation: Department of Urology, School of Medicine, Chiba University.
authors.forename: N
authors.initials: N
authors.lastname: Sekita
authors.forename: Y
authors.initials: Y
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Okano
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: O
authors.initials: O
authors.lastname: Matsuzaki
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000378:metabolism / Q000556:secondary; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes; D044162:Parathyroid Hormone-Related Protein; D010412:Penile Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D011506:Proteins / Q000378:metabolism
chemical_list: D004164:Diphosphonates; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins