Septins: cytoskeletal polymers or signalling GTPases?
Septins are a family of conserved proteins that have been implicated in a variety of cellular functions involving specialized regions of the cell cortex and changes in cell shape. The biochemistry and localization of septins suggest that they form a novel cytoskeletal system or that they function as scaffolds for the assembly of signalling complexes. This article discusses septin biochemistry and septin-interacting proteins, focusing on the missing link between the structure and biochemical properties of septin proteins, and on how they function at a molecular level in processes such as cytokinesis and yeast budding.
Field
C M
CM
Dept of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. cfield@hms.harvard.edu
Kellogg
D
D
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology*; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D008322:Mammals; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D020558:GTP Phosphohydrolases