title: Macrolide Analogues of the Novel Immunosuppressant Sanglifehrin: New Application of the Ring-Closing Metathesis Reaction.
abstract: Macrocycles containing a conjugated 1,3-diene moiety have been synthesized for the first time in good yields by the ring-closing metathesis reaction [Eq. (1)]. The new compounds represent cyclophilin-binding, simplified analogues of the macrocyclic core of sanglifehrin A, an immunosuppressant which binds with high affinity to cyclophilin.
authors.affiliation: Novartis Pharma AG, S-350.2.07, CH-4002 Basel (Switzerland).
authors.lastname: Martin Cabrejas LM
authors.initials: S
authors.lastname: Rohrbach
authors.initials: D
authors.lastname: Wagner
authors.initials: J
authors.lastname: Kallen
authors.initials: G
authors.lastname: Zenke
authors.initials: J
authors.lastname: Wagner