Prader-Willi syndrome.
Prader-Willi syndrome is a multi system disorder characterized by neonatal hypotonia, later obesity, hyperphagia and mental retardation. It occurs sporadically, either as a result of microdeletion of chromosome 15p (70%) or as a result of maternal disomy of chromosome 15 (30%). The major problems encountered by parents are those of hyperphagia, food-seeking and obesity, and conduct disorder, particularly tantrums or oppositional behaviour.
Couper
R
R
Department of Paediatrics, University of Adelaide, Women's and Children's Hospital, North Adelaide, South Australia, Australia. rcouper@medicine.adelaide.edu.au
D000293:Adolescent; D000328:Adult; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000209:etiology / Q000628:therapy; D002648:Child; D002884:Chromosomes, Human, Pair 15; D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D006963:Hyperphagia / Q000628:therapy; D007231:Infant, Newborn; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000209:etiology / Q000628:therapy; D011218:Prader-Willi Syndrome / Q000235:genetics / Q000503:physiopathology / Q000523:psychology