title: Viral-induced cirrhosis: grading of severity using MR imaging.
abstract: OBJECTIVE
  The purpose of this study was to determine whether MR imaging can be used to grade the severity of cirrhosis.
  
  
  METHODS
  The MR examinations of 46 patients with cirrhosis were retrospectively reviewed independently by two radiologists and correlated with clinical severity assessed by Child-Pugh classification. MR imaging analysis by reviewers who were unaware of clinical status included comparison of volume indexes (computed as the product of three axis measurements) of the spleen and each segment of the liver, and changes in hepatic contour, iron or fat deposition, and presence of varices and collaterals.
  
  
  RESULTS
  Volume index of the spleen and the presence of ascites and varices were significantly and positively correlated (p = .008, .002, .0001, respectively) with the clinical severity of cirrhosis (Child-Pugh classifications), and volume indexes of the posterior, medial, and lateral segments of the liver were significantly and inversely correlated (p = .001, .049, .041, respectively). On an MR scoring system based on four items (volume index of the spleen; volume index of posterior + medial + lateral segments; presence of ascites; and presence of varices and collaterals), averaged total MR scores were 2.5 +/- 0.3, 4.9 +/- 0.6, and 7.9 +/- 0.8 for Child-Pugh grades A, B, and C, respectively (p < .0001). The accuracy of MR scoring in distinguishing between clinical Child-Pugh grade A cirrhosis and further grades was 89%, the sensitivity was 93%, and the specificity was 82%.
  
  
  CONCLUSIONS
  An MR scoring system can be used to grade the severity of cirrhosis.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: D G
authors.initials: DG
authors.lastname: Mitchell
authors.forename: H W
authors.initials: HW
authors.lastname: Hann
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Okazaki
authors.forename: K
authors.initials: K
authors.lastname: Honjo
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
mesh_terms: D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006509:Hepatitis B / Q000150:complications / Q000473:pathology*; D006526:Hepatitis C / Q000150:complications / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000145:classification / Q000473:pathology* / Q000821:virology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA