Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH.
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth.
Armelin
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HA
Departamento de Bioquímica, Universidade de São Paulo, Brasil.
Lotfi
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CF
D000306:Adrenal Cortex Neoplasms / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000502:physiology*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos; D005346:Fibroblast Growth Factors; D000324:Adrenocorticotropic Hormone; D019950:Mitogen-Activated Protein Kinase 1