Acquired protein C deficiency following cisplatinum-navelbine administration for locally advanced breast cancer. Case report.
Thromboembolic events have recently been reported following diverse regimens of chemotherapy for breast cancer. This is a report of a 39-year-old woman, a diagnosed case of locally advanced breast cancer, who received many regimens of chemotherapy. She presented with deep venous thrombosis 2 months after starting the cisplatinum-navelbine regimen. Protein C deficiency was the only abnormal coagulation test that normalized after cessation of chemotherapy.
Taher
A
A
Department of Internal Medicine, American University of Beirut, Medical Center, Lebanon.
Shamsseddine
A
A
Saghir
N
N
Seoud
M
M
Mourad
F
F
Dabajah
B
B
Khalil
A
A
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects; D005260:Female; D006801:Humans; D020151:Protein C Deficiency / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D020246:Venous Thrombosis / Q000209:etiology; D014747:Vinblastine / Q000009:adverse effects / Q000031:analogs & derivatives; D000077235:Vinorelbine
D014747:Vinblastine; D002945:Cisplatin; D000077235:Vinorelbine