NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore.
Among non-smokers, the factors resulting in lung carcinogenesis are poorly understood. We conducted a hospital-based case-control analysis of 294 Chinese women, of whom 217 were non-smokers, to evaluate the role of polymorphic N-acetyltransferase (NAT2) as a susceptibility factor for the disease. The proportion of slow acetylator genotypes among non-smoking cases (n = 92) and controls (n = 125) was 38.0 and 24.0%, respectively [odds ratio (OR) 2.0, 95% confidence interval (CI) 1.1-3.7]. No effect of NAT2 genotype was seen among smokers. Among non-smokers, the effect was marked for adenocarcinomas (OR 2.1, 95% CI 1.1-4.0). As NAT2 activity is known to modify risk of arylamine-induced carcinogenesis, our results suggest that exposure to arylamines in the environment may play a role in risk of lung cancer among non-smokers.
Seow
A
A
Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, 16 Medical Drive, Singapore, 117597.
Zhao
B
B
Poh
W T
WT
Teh
M
M
Eng
P
P
Wang
Y T
YT
Tan
W C
WC
Lee
E J
EJ
Lee
H P
HP
D000107:Acetylation; D000230:Adenocarcinoma / Q000201:enzymology / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D000368:Aged; D000588:Amines / Q000009:adverse effects; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003296:Cooking; D004781:Environmental Exposure; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006571:Heterocyclic Compounds / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012846:Singapore / Q000453:epidemiology; D012907:Smoking / Q000453:epidemiology; D016540:Smoking Cessation / Q000706:statistics & numerical data; D014028:Tobacco Smoke Pollution / Q000706:statistics & numerical data
D000588:Amines; D006571:Heterocyclic Compounds; D014028:Tobacco Smoke Pollution; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human