title: A prospective coagulation study including resistance to activated protein C and mutations in factors V and II in venous leg ulcers.
abstract: Hypercoagulable states have been reported to be associated with venous leg ulcers. In an attempt to investigate the prevalence of hypercoagulable states in patients with venous leg ulcers, we performed a prospective case-control study for the presence of coagulation defects in such patients, including resistance to activated protein C (APC), factor V Leiden mutation and a newly described mutation in factor II. Results were compared with those obtained in a control group. APC resistance was found in four of 33 patients tested, but only one was found to be heterozygous for the factor V Leiden mutation. Factor II mutation was found in two of 30 patients tested. Our findings show that the prevalence of coagulation abnormalities is not different in patients with venous leg ulcers from controls in our study, suggesting that only selected patients with venous ulcers and a history of recurrent deep venous thrombosis should be investigated for the presence of coagulation defects.
authors.affiliation: Institut de Recherche sur la Peau Service de Dermatologie, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Ribeaudeau
authors.forename: P
authors.initials: P
authors.lastname: Senet
authors.forename: J M
authors.initials: JM
authors.lastname: Cayuela
authors.forename: X
authors.initials: X
authors.lastname: Fund
authors.forename: C
authors.initials: C
authors.lastname: Paul
authors.forename: C
authors.initials: C
authors.lastname: Robert
authors.forename: M L
authors.initials: ML
authors.lastname: Scrobohaci
authors.forename: L
authors.initials: L
authors.lastname: Dubertret
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D000990:Antithrombin III / Q000032:analysis; D001778:Blood Coagulation Disorders / Q000235:genetics*; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000097:blood / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics*; D018180:Thrombomodulin / Q000032:analysis
chemical_list: D017152:Antibodies, Antiphospholipid; D018180:Thrombomodulin; C095381:factor V Leiden; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin