title: Indolo[3,2-c]cinnolines with antiproliferative, antifungal, and antibacterial activity.
abstract: A series of indolo[3,2-c]cinnoline derivatives was prepared and tested to evaluate their biological activity. Most of them inhibited the proliferation of leukemia, lymphoma and solid tumor-derived cell lines at micromolar concentrations, whereas none of the compounds were active against HIV-1. With the exception of 7g, all title compounds showed antibacterial activity against gram-positive bacteria, being up to 200 times more potent than the reference drug streptomycin. Some of the indolo[3,2-c]cinnolines were also endowed with good antifungal activity, particularly against Criptococcus neoformans.
authors.affiliation: Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Barraja
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: A
authors.initials: A
authors.lastname: Lauria
authors.forename: A
authors.initials: A
authors.lastname: Passannanti
authors.forename: A M
authors.initials: AM
authors.lastname: Almerico
authors.forename: C
authors.initials: C
authors.lastname: Minnei
authors.forename: S
authors.initials: S
authors.lastname: Longu
authors.forename: D
authors.initials: D
authors.lastname: Congiu
authors.forename: C
authors.initials: C
authors.lastname: Musiu
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010793:Phthalazines / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007211:Indoles; D010793:Phthalazines