Selective effect of cyclosporine monotherapy for pure red cell aplasia not associated with granular lymphocyte-proliferative disorders.
Morphological characteristics of lymphocytes and the response to cyclosporine treatment have revealed some unique patients with pure red cell aplasia. Lymphocytes from these patients consisted mainly of non-granulated lymphocytes. All of the patients were successfully managed by cyclosporine monotherapy irrespective of prior treatment. A reduction in lymphocyte mass was not a prerequisite for the remission of pure red cell aplasia, and responses occurred within 1 month from the start of therapy. Clonal T-cell proliferation was detected in four patients, which raised the possibility of idiopathic pure red cell aplasia being associated with a clonal proliferation of T cells. An examination of the lymphocytes in patients with pure red cell aplasia could potentially be used to plan better therapeutic modalities and assess prognosis.
Yamada
O
O
Department of Haematology, Tokyo Women's Medical College, Tokyo, Japan. yamadoa@lab.twmc.ac.jp
Motoji
T
T
Mizoguchi
H
H
D000328:Adult; D000368:Aged; D002455:Cell Division; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012010:Red-Cell Aplasia, Pure / Q000188:drug therapy* / Q000235:genetics; D013601:T-Lymphocytes / Q000473:pathology; D016896:Treatment Outcome
D016572:Cyclosporine