title: Imidazothiadiazine dioxides: synthesis and antiviral activity.
abstract: A new series of imidazothiadiazine dioxides, including the first acyclonucleosides derived from this heterocycle moiety, has been synthesized. A wide-spectrum antiviral screening was performed. Some of the N-1 benzyl imidazothiadiazines and the new acyclonucleosides showed interesting anti-CMV or anti-HIV activity. These structures could be considered as new lead compounds for antiviral drug research.
authors.affiliation: Instituto de Química Médica (CSIC), Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: A I
authors.initials: AI
authors.lastname: Esteban
authors.forename: A
authors.initials: A
authors.lastname: Herrero
authors.forename: C
authors.initials: C
authors.lastname: Ochoa
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D013829:Thiadiazines