The role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome. A pilot experimental study.
OBJECTIVE
To evaluate the role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome (OHSS).


METHODS
A pilot experimental study.


METHODS
Ovarian hyperstimulation was induced in 5 rabbits using human menopausal gonadotropin/human chorionic gonadotropin, after pretreatment without (control group) or with bovine serum albumin (BSA group).


RESULTS
Despite an increase in serum protein levels, the BSA group showed comparable delta increase in body weight and degree of ascites formation.


CONCLUSIONS
Intravenous albumin did not prevent severe OHSS in a rabbit model despite the observed increase in serum oncotic pressure.
Orvieto
R
R
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
Abir
R
R
Kaplan
B
B
Bar-Hava
I
I
Ben-Rafael
Z
Z
D000818:Animals; D001201:Ascites / Q000188:drug therapy; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D007275:Injections, Intravenous; D016471:Ovarian Hyperstimulation Syndrome / Q000378:metabolism / Q000517:prevention & control*; D010865:Pilot Projects; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000627:therapeutic use*; D013997:Time Factors
D001798:Blood Proteins; D012710:Serum Albumin, Bovine