[Role of heat-shock proteins in cardioprotection of patients operated on for ischemic heart disease].
Major stress protein HSP72 is known to participate in protecting cells and organisms against harmful factors including ischemia, trauma etc. Under study was the level of HSP72 in the myocardium of 32 patients with coronary disease operated in Military-medical academy. HSP72 was detected in probes of the right atria before and after pre-cardiopulmonary bypass in all cases induction of HSP72 was observed in 40% of patients, and directly correlated with the time of cardiopulmonary bypass and standing of the disease. The cardioprotective effect of the elevated pre-operational level of HSP72 was shown to be proportionate to the lower activity of cardiospecific enzymes, creatine phosphokinase (CK-MB). It is suggested that HSP72 is involved in the mechanism of cardioprotection during cardiopulmonary bypass.
Shevchenko
Iu L
IuL
Demidov
O N
ON
Tyrenko
V V
VV
Svistov
A S
AS
Belevitin
A B
AB
Karpishchenko
A I
AI
Komarova
E Iu
EIu
Popova
T V
TV
Kinev
A V
AV
Margulis
B A
BA
D000328:Adult; D000368:Aged; D001011:Aorta / Q000601:surgery; D001706:Biopsy; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D003402:Creatine Kinase / Q000097:blood; D003627:Data Interpretation, Statistical; D004591:Electrophoresis, Polyacrylamide Gel; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology; D006360:Heat-Shock Proteins / Q000032:analysis / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology; D009206:Myocardium / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D003402:Creatine Kinase