[The inhibitory effects of antioxidant vitamins on serum oxLDL and experimental atherosclerosis of rabbits].
OBJECTIVE
In order to study the inhibitory effects of antioxidant vitamins on serum (low oxidative density lipoproteins, oxLDL) and experimental atherosclerosis in rabbits, 20 rabbits were fed on cholesterol rich diet and antioxidant vitamins (vitamin E, vitamin C and beta carotene) for 12 weeks. oxLDL were tested by ELISA at the beginning of experiment and after 4 weeks 8 weeks.


RESULTS
The results showed that supplement of antioxidant vitamins can decrease the oxLDL level significantly and inhibited development of atherosclerosis lesion around aorta in rabbits.
Chen
D
D
PUMC Hospital, Beijing.
Yang
T
T
Song
F
F
Ruan
G
G
Liu
S
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood* / Q000517:prevention & control; D001205:Ascorbic Acid / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D011817:Rabbits; D014810:Vitamin E / Q000494:pharmacology; D019207:beta Carotene / Q000494:pharmacology*
D000975:Antioxidants; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D019207:beta Carotene; D014810:Vitamin E; D001205:Ascorbic Acid