[The quantification of energy-rich phosphates in healthy and damaged heart muscle by SLOOP 31P-MR spectroscopy. Spatial localization with optimal pointspread function].
OBJECTIVE
A quantitative 31P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium.


METHODS
31P spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by 1H images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard.


RESULTS
31P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease.


CONCLUSIONS
31P-MR spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.
Beer
M
M
Institut für Röntgendiagnostik, Universität Würzburg. meinrad.beer@mail.uni-wuerzburg.de
Landschütz
W
W
Meininger
M
M
Seyfarth
T
T
Viehrig
M
M
Sandstede
J
J
Pabst
T
T
Kenn
W
W
Horn
M
M
Harre
K
K
von Kienlin
M
M
Neubauer
S
S
Hahn
D
D
D000255:Adenosine Triphosphate / Q000032:analysis; D002311:Cardiomyopathy, Dilated / Q000378:metabolism*; D004562:Electrocardiography; D004734:Energy Metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010710:Phosphates / Q000032:analysis*; D010725:Phosphocreatine / Q000032:analysis
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate