title: Intravenous lysine vasopressin lowers body temperature in normal and febrile pigs.
abstract: Vasopressin has been implicated as a centrally acting endogenous antipyretic. However, in several species, including the pig, plasma vasopressin concentrations increase during the early stages of fever. This experiment investigated the effects of intravenous lysine vasopressin on core temperature in normal and febrile swine. Lysine vasopressin (20 microg/pig) stimulated cortisol release and induced a 60-min hypothermic episode in normal animals, although a 10-fold lower dose was without effect. The peptide also delayed the pyretic response to bacterial endotoxin (20 microg intravenously). It is speculated that the hypothermic action of circulating vasopressin may involve nitric oxide.
authors.affiliation: Ministry of Agriculture, Fisheries, and Food, Department of Neurobiology, The Babraham Institute, Cambridge, United Kingdom. bob.parrott@bbsrc.ac.uk
authors.forename: R F
authors.initials: RF
authors.lastname: Parrott
authors.forename: S V
authors.initials: SV
authors.lastname: Vellucci
authors.forename: J A
authors.initials: JA
authors.lastname: Goode
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D005334:Fever / Q000188:drug therapy*; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D008236:Lypressin