title: Laminar cortical necrosis in central nervous system lupus: sequential changes in MR images.
abstract: A 44-year-old woman with systemic lupus erythematosus developed central nervous system lupus presenting with headache, fever, cloudiness of consciousness, and psychotic symptoms. T1-weighted and proton MR images showed laminar high intensity lesions in the parietal and temporal cortex bilaterally. T2-weighted images of the lesions showed low signal intensity. Treatment with corticosteroids alleviated the clinical symptoms within 7 months. The low T2 and high T1 signal abnormalities disappeared in a year and in 5 years, respectively. The laminar cortical lesions on MR images were suggested to represent cortical necrosis associated with central nervous system lupus.
authors.affiliation: Department of Neurology, Okayama University Medical School, Japan. kkashi@cc.okayama-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kashihara
authors.forename: S
authors.initials: S
authors.lastname: Fukase
authors.forename: I
authors.initials: I
authors.lastname: Kohira
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000328:Adult; D020274:Autoimmune Diseases of the Nervous System / Q000209:etiology* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D019965:Neurocognitive Disorders / Q000209:etiology*