Distribution, activity and concentration of cathepsin B and cystatin C in the wall of aortic aneurysm.
Intensity of immunohistochemical reaction to cathepsin B is stronger and to cystatin C weaker in the wall of aortic aneurysm than in normal aorta. Localization of cathepsin B and cystatin C in the aneurysm wall is different from that in the control aorta, but activity and concentration of cystatin C in the aneurysmal wall is lower than in normal aorta. The parietal thrombus of aneurysm also shows high activity of cathepsin B. The obtained results point to participation of cathepsin B in degradation of aneurysmal structural proteins and in enlargement of the aneurysmal size.
Gacko
M
M
Department of Vascular Surgery and Transplantology, University Medical School, Białystok.
Chyczewski
L
L
Chrostek
L
L
D000328:Adult; D000368:Aged; D001011:Aorta / Q000201:enzymology / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000201:enzymology* / Q000473:pathology; D002401:Cathepsin B / Q000378:metabolism*; D055316:Cystatin C; D015891:Cystatins / Q000378:metabolism*; D015853:Cysteine Proteinase Inhibitors / Q000378:metabolism*; D004247:DNA / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors; D004247:DNA; D002401:Cathepsin B