title: Color doppler imaging of the central retinal artery in premature infants undergoing examination for retinopathy of prematurity.
abstract: OBJECTIVE
  Recent attempts have been made to quantify blood flow velocity in the central retinal artery (CRA) of adults using color Doppler imaging (CDI). Although retinal vascular abnormalities are the hallmark of severe retinopathy of prematurity (ROP), normal values have not been established for CRA blood flow velocity in premature infants.
  
  
  METHODS
  CDI of the CRA was successfully performed on 43 eyes in 22 infants (postconceptional ages 32 to 39 weeks) before the infants underwent examination for ROP. Peak systolic velocity (PSV) and end diastolic velocity were recorded from at least 1 eye of each patient. Pourcelot's resistive index was then calculated for each eye studied.
  
  
  RESULTS
  Mean PSV for patients with no ROP (n = 6) was 7.2 +/- 1.5 cm/s, whereas those with any degree of ROP excluding plus disease (n = 9) had a mean PSV of 8.9 +/- 1.8 cm/s. Of the patients with ROP and plus disease (n = 7), the mean PSV was 7.0 +/- 1.6 cm/s. There were no statistically significant differences among these 3 groups (P= .08).
  
  
  CONCLUSIONS
  CDI can be successfully performed on preterm infants and yields values lower than those previously reported in healthy adult subjects. PSV in the CRA may be higher in subjects with ROP in the absence of plus disease; however, further study is needed to determine whether these differences are significant.
authors.affiliation: N. Edgar Miles Center for Pediatric Ophthalmology, Department of Ophthalmology, Medical University of South Carolina, Charleston 29425-2236, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Holland
authors.forename: R A
authors.initials: RA
authors.lastname: Saunders
authors.forename: L E
authors.initials: LE
authors.lastname: Kagemann
authors.forename: E C
authors.initials: EC
authors.lastname: Bluestein
authors.forename: A K
authors.initials: AK
authors.lastname: Hutchinson
authors.forename: D W
authors.initials: DW
authors.lastname: Corson
authors.forename: A
authors.initials: A
authors.lastname: Harris
mesh_terms: D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012161:Retinal Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D012178:Retinopathy of Prematurity / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012189:Retrospective Studies; D018615:Ultrasonography, Doppler, Color