title: [Therapeutic failure of melarsoprol among patients treated for late stage T.b. gambiense human African trypanosomiasis in Uganda].
abstract: The failure rate of melarsoprol after treatment of late stage cases of Human African Trypanosomiasis (HAT) is usually under 7%, even though the drug has been used for such treatment over the past 50 years. We report a melarsoprol treatment failure rate of 26.9% among 428 patients treated in Northern Uganda. Whatever its origin, this observation, the first documented in a HAT focus, is alarming, particularly since no second line trypanocidal drug is actually available for the treatment of late stage HAT. We believe that the current worrisome situation of HAT in several African countries and the risk of emergence of other foci of resistance, argue in favour of a greater attention on the part of the scientific community and the pharmaceutical companies being paid to this problem.
authors.affiliation: Epicentre, Kampala, Ouganda. epi@imul.com
authors.forename: D
authors.initials: D
authors.lastname: Legros
authors.forename: C
authors.initials: C
authors.lastname: Fournier
authors.forename: M
authors.initials: M
authors.lastname: Gastellu Etchegorry
authors.forename: F
authors.initials: F
authors.lastname: Maiso
authors.forename: E
authors.initials: E
authors.lastname: Szumilin
mesh_terms: D004351:Drug Resistance; D006801:Humans; D008549:Melarsoprol / Q000627:therapeutic use*; D017211:Treatment Failure; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014353:Trypanosomiasis, African / Q000188:drug therapy*; D014454:Uganda
chemical_list: D014344:Trypanocidal Agents; D008549:Melarsoprol