title: Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists.
abstract: We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus 43210-1291, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Bergmeier
authors.forename: D J
authors.initials: DJ
authors.lastname: Lapinsky
authors.forename: R B
authors.initials: RB
authors.lastname: Free
authors.forename: D B
authors.initials: DB
authors.lastname: McKay
mesh_terms: D000157:Aconitine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D019439:Chromaffin Cells / Q000187:drug effects / Q000378:metabolism; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; C054634:methyllycaconitine; D000157:Aconitine