title: Tc-99m-labeling of modified RNA.
abstract: The synthesis of Tc-99m-labeled, modified RNA is reported. This new class of radiopharmaceuticals is of potential interest as target specific imaging agents. The preparation of N3S-RNA was achieved by coupling protected MAG2-units to amino modified ON's. The N3S-RNA was Tc-99m-labeled with 90-95% radiochemical yield and specific activities of 37MBq/nmol leading to 1:1-Tc-99m-N3S-aptamers.
authors.affiliation: Schering AG, Research Laboratories, Berlin, FRG.
authors.forename: C S
authors.initials: CS
authors.lastname: Hilger
authors.forename: M C
authors.initials: MC
authors.lastname: Willis
authors.forename: M
authors.initials: M
authors.lastname: Wolters
authors.forename: W A
authors.initials: WA
authors.lastname: Pieken
mesh_terms: D001483:Base Sequence; D015609:Organotechnetium Compounds / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000737:chemistry*
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012313:RNA