The prolactin response to fenfluramine in schizophrenia is associated with negative symptoms.
We examined the serotonergic system in drug-free inpatients [schizophrenia (n=28) and schizoaffective (n=7)] by administering a challenge dose of oral dl-fenfluramine (fenfluramine) in a controlled angiocatheter study. Seventeen of these patients were also randomized to a placebo condition in addition to receiving fenfluramine. Response to fenfluramine as reflected by changes in serum prolactin and cortisol were examined by repeated measures ANOVA, as well as Area Under the Curves (AUCs). The prolactin response, but not the cortisol response, was significantly correlated with measures of negative symptoms.
Sharma
R P
RP
Department of Psychiatry, University of Illinois at Chicago, USA.
Singh
V
V
Janicak
P G
PG
Javaid
J I
JI
Pandey
G N
GN
D000284:Administration, Oral; D000328:Adult; D010054:Brief Psychiatric Rating Scale; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis*; D012720:Severity of Illness Index
D005277:Fenfluramine; D011388:Prolactin; D006854:Hydrocortisone