title: Lesion volume and clinical outcome in stereotactic pallidotomy and thalamotomy.
abstract: Postoperative lesion volume and clinical outcome were assessed in 19 Parkinson's disease (PD) patients who received posteroventral pallidotomy, and in 14 essential tremor (ET) patients who received ventrolateral thalamotomy. Before and after surgery, PD patients were evaluated using the Unified PD Rating Scale (UPDRS), and ET patients were evaluated using the Fahn-Tolosa-Marin (FTM) tremor rating scale. Inner and total lesion volumes were determined with postoperative MR imaging and three-dimensional data segmentation. Lesion volumes were compared to percent improvement in UPDRS and FTM scores, using Spearman's rank-order correlation test. No rank-order correlations were found between lesion volume and clinical improvement in either the PD or the ET patients. In performing stereotactic surgery for movement disorders, any lesion volume within a prescribed range may be equally effective in relieving symptoms associated with PD or ET.
authors.affiliation: Imaging Resource Center, University of Kansas Medical Center, Kansas City, KS 66103, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Goodman
authors.forename: S
authors.initials: S
authors.lastname: Wilkinson
authors.forename: J
authors.initials: J
authors.lastname: Overman
authors.forename: W C
authors.initials: WC
authors.lastname: Koller
authors.forename: A
authors.initials: A
authors.lastname: Tröster
authors.forename: R
authors.initials: R
authors.lastname: Pahwa
authors.forename: K
authors.initials: K
authors.lastname: Lyons
authors.forename: J
authors.initials: J
authors.lastname: Kieltyka
authors.forename: J
authors.initials: J
authors.lastname: Burns
authors.forename: M
authors.initials: M
authors.lastname: Gordon
mesh_terms: D000368:Aged; D005260:Female; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000601:surgery*; D016896:Treatment Outcome