title: Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans.
abstract: To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.
authors.affiliation: Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA. sufuo001@tc.umn.edu
authors.forename: M
authors.initials: M
authors.lastname: Sofuoglu
authors.forename: S
authors.initials: S
authors.lastname: Dudish-Poulsen
authors.forename: D
authors.initials: D
authors.lastname: Nelson
authors.forename: P R
authors.initials: PR
authors.lastname: Pentel
authors.forename: D K
authors.initials: DK
authors.lastname: Hatsukami
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology; D016578:Crack Cocaine; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology* / Q000523:psychology; D011374:Progesterone / Q000097:blood; D012727:Sex Characteristics; D011795:Surveys and Questionnaires
chemical_list: D016578:Crack Cocaine; D018765:Dopamine Uptake Inhibitors; D011374:Progesterone; D004958:Estradiol; D003042:Cocaine