Which T cells cause psoriasis?
Today, T cells appear to be the main protagonists in the pathogenesis of psoriasis vulgaris. This article summarizes how T cells might contribute to the generation of psoriatic skin lesions. It discusses the preferential T cell receptor usage and the putative mode of T cell activation in psoriatic skin lesions, and how streptococcal throat infections could be involved in disease manifestations. The results are integrated into a pathogenetic concept which considers psoriasis as a T-cell mediated autoimmune disorder.
Prinz
J C
JC
Department of Dermatology, Klinikum Innenstadt, Ludwig-Maximilians-University, Munich, Germany. joerg.prinz@irz.uni-muenchen.de
D001327:Autoimmune Diseases / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology; D015329:Gene Rearrangement, T-Lymphocyte / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D008213:Lymphocyte Activation / Q000502:physiology; D010612:Pharyngitis / Q000382:microbiology; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013290:Streptococcal Infections / Q000276:immunology / Q000503:physiopathology; D018089:Superantigens / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*
D011948:Receptors, Antigen, T-Cell; D018089:Superantigens