title: Chronic lymphoedema and angiosarcoma.
abstract: Angiosarcoma has frequently been described arising within chronic lymphoedema of the upper limb following mastectomy and radiotherapy for carcinoma of the breast. We report a case of angiosarcoma arising in a lymphoedematous leg that had been subjected to radiotherapy 20 years previously for Hodgkin's disease. The diagnosis was expedited once the patient noticed the development of bleeding nodules. Prognosis of angiosarcoma is poor with treatment options being wide-excision surgery, palliative radiotherapy or chemotherapy. Unusual bruised areas or bleeding nodules developing within chronic lymphoedematous limbs should be biopsied to exclude the diagnosis.
authors.affiliation: Department of Dermatology, The Royal Liverpool University Hospital NHS Trust, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Azurdia
authors.forename: D M
authors.initials: DM
authors.lastname: Guerin
authors.forename: J L
authors.initials: JL
authors.lastname: Verbov
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002908:Chronic Disease; D017809:Fatal Outcome; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007866:Leg / Q000528:radiation effects; D008204:Lymphangiosarcoma / Q000209:etiology*; D008209:Lymphedema / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000209:etiology*; D010166:Palliative Care; D011379:Prognosis; D012878:Skin Neoplasms / Q000209:etiology*