title: A programme for short-term withdrawal from benzodiazepines in geriatric hospital inpatients: success rate and effect on subjective sleep quality.
abstract: OBJECTIVE
  We tested the hypothesis that a short-term programme for withdrawal of benzodiazepines (BZD) is feasible in hospitalized geriatric patients.
  
  
  METHODS
  Fifty-six geriatric subjects who had been taking BZD for at least 3 months were asked to discontinue these drugs upon admission to the inpatient ward. A withdrawal programme including initial substitution therapy combined with psychological consulting was offered. The usual BZD medication was replaced by either lormetazepam 1 mg or trazodone 50 mg, administered at bedtime. After 1 week of replacement therapy all sedative medication was stopped. The subjective estimations of sleep quality were evaluated four times during a period of 6 weeks.
  
  
  RESULTS
  Forty-nine patients agreed to participate. In this group four subjects (8.2%) resumed BZD use while in the hospital and another seven subjects (14.3%) relapsed after discharge. Therefore, the overall success rate was 77.6% in the group of volunteers and 67. 9% in the total group of eligible patients. The data of the present study further demonstrate that no major withdrawal symptoms occurred and that the subjective quality of sleep remained virtually unchanged in the course of the programme. The sleep quality was not significantly different in patients on trazodone versus patients on lormetazepam. The success rate was similar in both drug substitution groups.
  
  
  CONCLUSIONS
  Short-term withdrawal of BZD may be achieved in two-thirds of elderly hospital inpatients without deterioration of sleep quality or other deleterious side-effects.
authors.affiliation: Service of Internal Medicine, University Hospital, Ghent, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Petrovic
authors.forename: D
authors.initials: D
authors.lastname: Pevernagie
authors.forename: N
authors.initials: N
authors.lastname: Van Den Noortgate
authors.forename: A
authors.initials: A
authors.lastname: Mariman
authors.forename: W
authors.initials: W
authors.lastname: Michielsen
authors.forename: M
authors.initials: M
authors.lastname: Afschrift
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance; D012893:Sleep Wake Disorders / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders / Q000534:rehabilitation*
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines