Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein.
The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernatant of SiHa cells, a cervical carcinoma cell line. Extracellular E7 protein, acting as a viral toxin in human immune cells, induces the overproduction of the immune suppressive IFN alpha cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These effects should be taken into account for the design of anti-human cervical carcinoma vaccines.
Le Buanec
H
H
Laboratoire de Physiologie Cellulaire, Pierre et Marie Curie University, Paris, France.
Lachgar
A
A
D'Anna
R
R
Zagury
J F
JF
Bizzini
B
B
Bernard
J
J
Ittelé
D
D
Hallez
S
S
Giannouli
C
C
Burny
A
A
Zagury
D
D
D000818:Animals; D002846:Chromatography, Affinity; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D004926:Escherichia coli / Q000502:physiology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*; D020382:Interleukin-18 / Q000276:immunology; D009856:Oncogene Proteins, Viral / Q000494:pharmacology*; D050725:Papillomavirus E7 Proteins; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
D016207:Cytokines; D007166:Immunosuppressive Agents; D020382:Interleukin-18; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16