Stability and compatibility of tacrolimus and fluconazole in 0.9% sodium chloride.
OBJECTIVE
To determine the physical compatibility and chemical stability of tacrolimus injection and fluconazole injection combined in a range of concentrations used clinically for intravenous Y-site co-administration over 3 hours.


METHODS
Tacrolimus injection (Prograf) was combined with fluconazole injection (Diflucan) in volumetric glass flasks at room temperature (23 degrees C to 25 degrees C) to form final concentrations of 5 or 20 micrograms/mL and 500 or 1,500 micrograms/mL, respectively. Immediately after preparation and at 1.5 and 3 hours, triplicate samples and controls were visually inspected and assayed in duplicate by high-performance liquid chromatography; pH of the samples was also determined.


METHODS
University of Michigan College of Pharmacy.


METHODS
Not applicable.


METHODS
Not applicable.


METHODS
Initial and subsequent concentrations of tacrolimus and fluconazole at 1.5 and 3 hours.


RESULTS
More than 99% of the initial concentration of each drug remained in all samples throughout the study period. There was no color change, and the pH of the samples did not change appreciably.


CONCLUSIONS
Tacrolimus and fluconazole are stable and compatible in a range of clinically used concentrations for 3 hours and can be intravenously co-administered through a Y-site.
Johnson
C E
CE
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065, USA. cejohn@umich.edu
Truong
N M
NM
D000935:Antifungal Agents / Q000737:chemistry*; D003131:Combined Modality Therapy; D004344:Drug Incompatibility; D004347:Drug Interactions; D004355:Drug Stability; D015725:Fluconazole / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry*; D016559:Tacrolimus / Q000737:chemistry*; D013997:Time Factors
D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D012965:Sodium Chloride; D015725:Fluconazole; D016559:Tacrolimus