title: Chronic tolerance and sensitization to alcohol in sons of alcoholics: II. Replication and reanalysis.
abstract: Data from D. B. Newlin and J. B. Thomson (1991) were reanalyzed, and data from an independent replication study were analyzed, relative to tonic (baseline) and phasic (response to alcohol challenge) aspects of drinking alcohol administered at the same dose on several occasions. Among the high-risk men (sons of alcoholic fathers), linear trends across days for resting (predrinking) baselines were opposite to alcohol-evoked changes for finger pulse amplitude, finger temperature, and skin conductance in Study 1 and for pulse transit time and body sway (static ataxia) in Study 2. In contrast, the structure of the low-risk men's (sons of nonalcoholic parents) data was precisely the opposite. Results are discussed in terms of sensitization as a potential mechanism that relates vulnerability to final manifestation of addictive behavior.
authors.affiliation: Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA. dnewlin@irp.nida.nih.gov
authors.forename: D B
authors.initials: DB
authors.lastname: Newlin
authors.forename: J B
authors.initials: JB
authors.lastname: Thomson
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D004856:Postural Balance / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012307:Risk Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol