Apolipoprotein E promoter and alpha2-macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease.
In this study, we investigated two newly reported polymorphisms in association with late onset Alzheimer's disease (AD) in Chinese. They were a -491 A/T polymorphism in the Apolipoprotein E (APOE) promoter region and a five base pair deletion at exon 18 of alpha2-Macroglobin (A2M). There were 196 AD and 180 normal controls (N), which were age- and sex-matched. APOE epsilon4 alleles were significantly increased in AD vs. N (chi2 = 33.3, P < 0.000001). However, neither the -491 A/T (chi2 = 1.13, P = 0.29) nor A2M (chi2 = 0.18, P = 0.67) polymorphism was associated with AD risk, suggesting that these polymorphisms do not represent risk factors for AD in the Chinese population.
Chen
L
L
Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Shatin.
Baum
L
L
Ng
H K
HK
Chan
L Y
LY
Sastre
I
I
Artíga
M J
MJ
Valdivieso
F
F
Bullido
M J
MJ
Chiu
H F
HF
Pang
C P
CP
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005091:Exons; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006723:Hong Kong; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012016:Reference Values; D017384:Sequence Deletion; D000511:alpha-Macroglobulins / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000511:alpha-Macroglobulins