Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent.
This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.
Mashiko
H
H
Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima-City, Japan.
Niwa
S
S
Kumashiro
H
H
Kaneko
Y
Y
Suzuki
S
S
Numata
Y
Y
Horikoshi
R
R
Watanabe
Y
Y
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage* / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D014196:Trazodone / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D014196:Trazodone