Regional cerebral glucose metabolism and blood flow in a patient with Marchiafava-Bignami disease.
We report functional neuroimaging studies of a 54-year-old man with Marchiafava-Bignami disease (MBD). Glucose metabolic images obtained by [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography showed diffusely reduced whole brain metabolism and strongly decreased metabolism in the frontal and parietal lobes, orbital gyrus, and thalamus. Cerebral perfusion images showed a similarly decreased radioactivity pattern as the metabolic images. Functional neuroimages would be useful for understanding the pathophysiologic processes of MBD.
Ishii
K
K
Division of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Ikerjiri
Y
Y
Sasaki
M
M
Kitagaki
H
H
Mori
E
E
D019973:Alcohol-Related Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D020367:Iofetamine; D005947:Glucose