title: Relapse and mortality among HIV-infected and uninfected patients with tuberculosis successfully treated with twice weekly directly observed therapy in rural South Africa.
abstract: OBJECTIVE
  To determine post-treatment relapse and mortality rates among HIV-infected and uninfected patients with tuberculosis treated with a twice-weekly drug regimen under direct observation (DOT).
  
  
  METHODS
  Hlabisa, South Africa.
  
  
  METHODS
  A group of 403 patients with tuberculosis (53% HIV infected) cured following treatment with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E) given in hospital (median 17 days), followed by HRZE twice weekly to 2 months and HR twice weekly to 6 months in the community under DOT.
  
  
  METHODS
  Relapses were identified through hospital readmission and 6-monthly home visits. Relapse (culture for Mycobacterium tuberculosis) and mortality given as rates per 100 person-years observation (PYO) stratified by HIV status and history of previous tuberculosis treatment.
  
  
  RESULTS
  Mean (SD) post-treatment follow-up was 1.2 (0.4) years (total PYO = 499); 78 patients (19%) left the area, 58 (14%) died, 248 (62%) remained well and 19 (5%) relapsed. Relapse rates in HIV-infected and uninfected patients were 3.9 [95% confidence interval (CI) 1.5-6.3] and 3.6 (95% CI 1.1-6.1) per 100 PYO (P = 0.7). Probability of relapse at 18 months was estimated as 5% in each group. Mortality was four-fold higher among HIV-infected patients (17.8 and 4.4 deaths per 100 PYO for HIV-infected and uninfected patients, respectively; P<0.0001). Probability of survival at 24 months was estimated as 59% and 81%, respectively. We observed no increase in relapse or mortality among previously treated patients compared with new patients. A positive smear at 2 months did not predict relapse or mortality.
  
  
  CONCLUSIONS
  Relapse rates are acceptably low following successful DOT with a twice weekly rifampicin-containing regimen, irrespective of HIV status and previous treatment history. Mortality is substantially increased among HIV-infected patients even following successful DOT and this requires further attention.
authors.affiliation: Centre for Epidemiological Research in South Africa, Medical Research Council, Durban.
authors.forename: C
authors.initials: C
authors.lastname: Connolly
authors.forename: A
authors.initials: A
authors.lastname: Reid
authors.forename: G
authors.initials: G
authors.lastname: Davies
authors.forename: W
authors.initials: W
authors.lastname: Sturm
authors.forename: K P
authors.initials: KP
authors.lastname: McAdam
authors.forename: D
authors.initials: D
authors.lastname: Wilkinson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality*; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011336:Probability; D012008:Recurrence; D012423:Rural Health; D013019:South Africa; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality* / Q000517:prevention & control
chemical_list: D000995:Antitubercular Agents