title: 9-Deoxopodophyllotoxin derivatives as anti-cancer agents.
abstract: Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung cancer cell lines.
authors.affiliation: Natural Products division, Dr. Reddy's Research Foundation, Hyderabad, India.
authors.forename: D
authors.initials: D
authors.lastname: Subrahmanyam
authors.forename: B
authors.initials: B
authors.lastname: Renuka
authors.forename: G S
authors.initials: GS
authors.lastname: Kumar
authors.forename: V
authors.initials: V
authors.lastname: Vandana
authors.forename: D S
authors.initials: DS
authors.lastname: Deevi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011034:Podophyllotoxin