Bullous systemic lupus erythematosus (type I) in a dog.
In human patients with systemic lupus erythematosus, cutaneous subepidermal blistering can occur because of the production of antibodies specific for basement membrane antigens. This condition is referred to as bullous systemic lupus erythematosus (BSLE). A dog was diagnosed with BSLE because it fulfilled the following criteria: (i) a diagnosis of systemic lupus erythematosus by standard methods; (ii) an acquired, vesicular, erosive and ulcerative eruption; (iii) microscopical subepidermal vesicles with neutrophil-predominant inflammation at the dermo-epidermal junction; (iv) deposition of IgG at the epidermal basement membrane zone; and (v) circulating IgG autoantibodies against type VII collagen. Anti-collagen VII type I-BSLE therefore needs to be considered as a possible differential diagnosis for canine autoimmune subepidermal blistering diseases.
Olivry
T
T
Department of Companion Animal and Special Species, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
Savary
K C
KC
Murphy
K M
KM
Dunston
S M
SM
Chen
M
M
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D003094:Collagen / Q000276:immunology; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D004285:Dogs; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*
D001323:Autoantibodies; D003622:Dapsone; D003094:Collagen; D011241:Prednisone