title: Sialoblastoma and epithelial tumors in children: their morphologic spectrum and distribution by age.
abstract: This commentary addresses the histologic spectrum of salivary gland neoplasms in children with emphasis on perinatal tumors. Histopathologically, perinatal tumors fall into four categories: 1) histologically benign with adult counterpart, 2) hamartomas 3) embryomas-sialoblastomas, and 4) histologically and biologically malignant adult analogue tumors. Although the criteria to serrate benign from malignant sialoblastomas are not well-established, the following histologic features would favor an aggressive clinical course: perineural and/or vascular spaces invasion, necrosis, and a cytologic atypia beyond the expected for embryonic epithelium.
authors.affiliation: Department of Pathology, University of Texas, M.D. Anderson Cancer Center, Houston, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Luna
mesh_terms: D017677:Age Distribution; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000628:therapy