Ubiquitous expression of a Drosophila adenomatous polyposis coli homolog and its localization in cortical actin caps.
We report the expression pattern of a new adenomatous polyposis coli (APC) homolog called E-APC during Drosophila development. E-APC protein is expressed in all embryonic and larval cells we have examined. In the early blastoderm embryo, we see a striking concentration of E-APC in the cortical actin caps. Microtubules are closely associated with these caps. Since human APC has been reported to bind to microtubules, we investigated whether the cortical E-APC co-localizes with tubulin. However, this was not the case, implying that the putative tubulin-binding property of human APC is not well conserved.
Yu
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MRC Laboratory of Molecular Biology, Cambridge, UK.
Bienz
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D000199:Actins / Q000378:metabolism* / Q000648:ultrastructure; D025601:Adenomatous Polyposis Coli Protein; D000818:Animals; D051186:Armadillo Domain Proteins; D001756:Blastoderm / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism*; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D019476:Insect Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D007814:Larva; D008870:Microtubules / Q000378:metabolism; D008969:Molecular Sequence Data; D012469:Salivary Glands / Q000254:growth & development / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors; D014404:Tubulin / Q000276:immunology / Q000378:metabolism
C495305:ARM protein, Drosophila; D000199:Actins; D025601:Adenomatous Polyposis Coli Protein; D051186:Armadillo Domain Proteins; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D014404:Tubulin