Concurrent administration of amrinone with nitric oxide most improves PaO2/FiO2 in acute respiratory and cardiac failure.
A 55-year-old man developed acute respiratory failure, pulmonary hypertension and left heart failure due to acute myocardial infarction. Nitric oxide (NO) inhalation improved arterial oxygenation, decreased pulmonary arterial pressure and increased cardiac output (CO), but combined use of dobutamine with NO produced increases in pulmonary arterial pressure and pulmonary capillary wedge pressure (PCWP). In this patient, amrinone decreased pulmonary arterial pressure and PCWP, and increased PaO2/FiO2 effectively while increasing CO. Combined use of inhaled NO and intravenous amrinone may have beneficial effects for a patient with acute respiratory and cardiac failure.
Yukioka
H
H
Division of Critical Care Medicine, Osaka City University Medical School, Japan.
Hayashi
M
M
Yamada
T
T
Fujimori
M
M
D000208:Acute Disease; D000676:Amrinone / Q000008:administration & dosage*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D009569:Nitric Oxide / Q000008:administration & dosage*; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000209:etiology; D014665:Vasodilator Agents / Q000008:administration & dosage*
D002316:Cardiotonic Agents; D014665:Vasodilator Agents; D009569:Nitric Oxide; D000676:Amrinone