9-Deoxopodophyllotoxin derivatives as anti-cancer agents.
Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung cancer cell lines.
Subrahmanyam
D
D
Natural Products division, Dr. Reddy's Research Foundation, Hyderabad, India.
Renuka
B
B
Kumar
G S
GS
Vandana
V
V
Deevi
D S
DS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011034:Podophyllotoxin