title: [Clinical evaluation and significance of measurement of airway hyperresponsiveness in COPD].
abstract: Airway hyperresponsiveness (HR) is one of the clinical characteristics of bronchial asthma and COPD. HR of COPD has been known to correlate with progress of pulmonary function in COPD. In order to evaluate the necessity of HR measurement, HR of COPD alone, COPD with asthma, asthma and control subjects was compared. Patients with COPD alone exhibited weak HR, while COPD with asthma represented severe HR, which was the same degree with asthmatics. From these results, we should be cautious in measurement of HR in COPD. Especially patients with FEV1 less than 1 L should be prevented from HR test.
authors.affiliation: Dept. Pulmonary Medicine, University of Tsukuba.
authors.forename: K
authors.initials: K
authors.lastname: Masuyama
authors.forename: R
authors.initials: R
authors.lastname: Tsunematsu
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000328:Adult; D000368:Aged; D000403:Airway Resistance; D001249:Asthma / Q000150:complications / Q000503:physiopathology; D016535:Bronchial Hyperreactivity; D001985:Bronchial Provocation Tests / Q000379:methods*; D016085:Bronchoconstrictor Agents; D000075202:Contraindications; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000503:physiopathology*; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D011379:Prognosis
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride