title: Metabolic and hormonal changes during aerobic exercise in distance runners.
abstract: A group of long-distance runners is studied in order to clarify aspects concerning neuroendocrine mechanisms regulating organic adaptation to maximum effort, with special interest in the function of the growth hormone in fat metabolism and the possible use of ketone bodies as an alternative source of energy. A test is designed on a treadmill with a gradient of 3% and progressive increases in speed of 2 Km/h every 10 min, starting at 6 Km/h, and continuing until exhaustion. Masks are worn to enable the breath by breath measurement of expired gases and the subjects are monitored electrocardiographically using V5. For blood sample collection an antecubital vein is catheterized with a system enabling the replacement of the blood volume extracted by means of perfusion with physiological saline solution, and the increasing concentration of hormones in the blood is evaluated. The results obtained, indicate that epinephrine as well as GH hormones increase significatively from 20 min of exercise in runners promoting changes from carbohydrates to lipids as fuels to carry out exercise. The concomitant variations in energy substrates support the former hypothesis of work. Moreover, the muscle could employ acetylCoA originating from acetoacetate as an alternative metabolic source of fuel during maximum effort.
authors.affiliation: Unidades de Investigación de Fisiología del Ejercicio, Facultad de Medicina, Universidad de Málaga, Spain.
authors.forename: V J
authors.initials: VJ
authors.lastname: Fernández-Pastor
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: A M
authors.initials: AM
authors.lastname: Diego-Acosta
authors.forename: C
authors.initials: C
authors.lastname: Avila
authors.forename: J C
authors.initials: JC
authors.lastname: García
authors.forename: F
authors.initials: F
authors.lastname: Pérez
authors.forename: F
authors.initials: F
authors.lastname: Guirado
authors.forename: N
authors.initials: N
authors.lastname: Noguer
mesh_terms: D000273:Adipose Tissue / Q000502:physiology; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D004837:Epinephrine / Q000097:blood / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D013006:Growth Hormone / Q000097:blood / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007657:Ketone Bodies / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D012143:Respiratory Physiological Phenomena
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D019344:Lactic Acid; D013006:Growth Hormone; D005990:Glycerol; D004837:Epinephrine