title: [Adverse effects of anti-thymocyte globulin/anti-lymphocyte globulin therapy].
abstract: This single-centre study evaluated the adverse effects of anti-thymocyte globulin (ATG) and anti-lymphocyte globulin (ALG) as used for the treatment of aplastic anemia and/or for conditioning regimens prior to stem cell transplantation. ATG/ALG was given to 29 patients a total of 37 times. The incidence of adverse effects was 62.1% (23/37), and fever was the most frequent adverse effect. Therapy was discontinued in only 4 patients (10.8%) due to severe adverse effects. Adverse effects occurred more frequently with ATG (rabbit-derived) than with ALG (horse-derived). Seven patients underwent 2 or 3 cycles of ATG/ALG therapy, for a combined total of 8 times; 6 of those patients (75% (6/8)) experienced adverse effects. Shorter intervals between repeated cycles of therapy appeared to heighten the risk of adverse reactions.
authors.affiliation: Department of Pediatrics, Hokkaido University School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Kaneda
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Iguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Cho
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Arioka
authors.forename: H
authors.initials: H
authors.lastname: Naito
authors.forename: T
authors.initials: T
authors.lastname: Shikano
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*; D019172:Transplantation Conditioning
chemical_list: D000961:Antilymphocyte Serum