The effects of depot leuprorelin on IVF.
The trial studied the effects of depot leuprorelin on the IVF cycle and was done on nine couples. A single intramuscular injection of depot leuprorelin was given to the woman a couple days before ovulation. Seven days after ovulation, the serum progesterone level was measured and showed the same normal level as the natural ovulatory cycle. The progesterone levels varied from 12.59 to 96.0 ng/ml. On day three of the menstruation, the hormonal profiles showed a complete pituitary and ovarian suppression. FSH, LH and estrogen levels were less than 4.1 mIU/ml, 2.8 mIU/ml and 9.4 pg/ml respectively. The hMG stimulation took 11 days on average (9-15 days). A hundred and two oocytes were retrieved and among these there were 86 mature oocytes (84.3%). All oocytes were inseminated despite prematurity and resulted in 82.35 per cent fertilization. Normal fertilization occurred in 77.45 per cent (79/102). Good embryos developed in 58.23 per cent (46/79). No more than three embryos were transferred. Four women conceived, among them there was a set of twins. The implantation rate was 44.44 per cent (4/9). One abortion was found in the early first trimester. The take home baby rate was 33.33 per cent (3/9).
Choavaratana
R
R
Department of Obstetrics and Gynecology, Faculty of Medicine, Mahidol University, Bangkok, Thailand.
Suppinyopong
S
S
Karavakul
C
C
Nilas
M
M
D000328:Adult; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000188:drug therapy*; D007273:Injections, Intramuscular; D016729:Leuprolide / Q000008:administration & dosage*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy / Q000706:statistics & numerical data*; D016896:Treatment Outcome
D003692:Delayed-Action Preparations; D005300:Fertility Agents, Female; D016729:Leuprolide