title: [Clinical success of treatment of chronic otitis media using topical and peroral administration of ofloxacin].
abstract: The paper presents results of the treatment of 32 patients (35 ears) with chronic otitis media and long lasting purulent otorrhea with local and oral ofloxacin. The patients were divided in two groups. Group A included 17 patients (49%), with previous middle ear surgery. Group B comprised 15 patients (18 ears, 51%) treated with local and systemic antimicrobial drugs. Ofloxacin was administered after taking the swab sample, and the duration of treatment was the same in all patients. The most frequently isolated microorganisms were P. aeruginosa (50%), S. aureus (17.7%) and Proteus sp. (14.7%). Upon the completion of treatment which lasted two weeks, 76% of patients in group A had no otorrhea, and in group B 95% of patients were free of otorrhea. At follow-up three months after the treatment, the success rate of ofloxacin therapy remained the same in group A. In group B in four cases there was recurrence of otorrhea, so the success rate in this group decreased to 72%. Ofloxacin treatment gave good result in reduction of otorrhea, regardless of the earlier treatment of chronic otitis media.
authors.affiliation: Sluzba za bolesti uha, grla i nosa, Opća bolnica Zadar.
authors.forename: M
authors.initials: M
authors.lastname: Kovacić
authors.forename: B
authors.initials: B
authors.lastname: Dzelalija
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage*; D010035:Otitis Media, Suppurative / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin