[Isolation and identification of antibiotics produced by Actinoplanes brasiliensis INA 3802].
In the screening programme for new antibiotics produced by Actinoplanes brasiliensis an antibiotic complex A-3802 was isolated and studied in detail. It had a marked therapeutic effect in the treatment of staphylococcal sepsis in albino mice and was low toxic. Two components of the complex i.e. A-3802-IV-3 and A-3802-IV-4 were identified with the lantibiotics actagardin and its diamide disulfoxide. Antibiotics A-3802-V-4 and A-3802-VI-7 were shown to be new antibiotics of the same group.
Katrukha
G S
GS
Research Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow.
Fedorova
G B
GB
Arkhangel'skaia
N M
NM
Iassein
M
M
Laĭko
A V
AV
Trifonova
Zh P
ZhP
D000192:Actinomycetales / Q000378:metabolism*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification*; D001407:Bacillus / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D051379:Mice; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data
D000596:Amino Acids; D000900:Anti-Bacterial Agents