title: Assessment of outcome by EC/IC bypass with 123I-iomazenil brain SPECT.
abstract: We report two patients with occlusive cerebrovascular disease who were examined by means of benzodiazepine receptor SPECT(BZR-SPECT) with 123I-iomazenil (IMZ) before extracranial-intracranial bypass surgery (EC/IC bypass). Preoperative low perfusion areas detected by cerebral blood flow SPECT (CBF-SPECT) were divided into two parts on BZR-SPECT images. In the low perfusion areas where the BZR were preserved, regional cerebral blood flow (rCBF) increased on postoperative CBF-SPECT, but where the BZR were not preserved, rCBF did not increase on postoperative CBF-SPECT. On visual inspection, the SPECT images of postoperative CBF-SPECT appeared similar to those of preoperative BZR-SPECT. For evaluation of the ischemic brain condition itself, instead of the cerebral metabolism, the distribution and activity of cerebral neurons indicated by BZR-SPECT with IMZ might be utilized.
authors.affiliation: Department of Neurosurgery, Asahikawa Red Cross Hospital, Japan. makky97@hokkai.or.jp
authors.forename: K
authors.initials: K
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Kamiyama
authors.forename: H
authors.initials: H
authors.lastname: Takamura
authors.forename: S
authors.initials: S
authors.lastname: Gotoh
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications; D001921:Brain / Q000000981:diagnostic imaging*; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000150:complications; D002539:Cerebral Arterial Diseases / Q000150:complications; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000601:surgery*; D002548:Cerebral Revascularization; D005442:Flumazenil / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011963:Receptors, GABA-A / Q000032:analysis; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011963:Receptors, GABA-A; D005442:Flumazenil; C063038:iomazenil