Fetal alcohol exposure attenuates interleukin-1beta-induced fever: neuroimmune mechanisms.
Central mechanisms for the attenuating effects of fetal alcohol exposure (FAE) on interleukin-1beta (IL-1beta)-induced fever were studied in adult male offspring of dams fed a liquid diet supplemented with ethanol (E), in pair-fed (P) control and in normal (N) offspring. Hypothalamic levels of IL-1 were significantly lower in E than in N rats at 2 h, but not at 4 and 6 h, after intraperitoneal administration of lipopolysaccharide. Fever induced by intracerebroventricular (i.c.v.) IL-1 was significantly lower in E than in N and P rats. In contrast, E rats showed a normal febrile response to i.c.v. prostaglandin-E2. Thus, whereas FAE does not affect central thermoregulatory mechanisms, per se, FAE alters the kinetics of hypothalamic IL-1 production/appearance and decreases the responsiveness of central mechanisms which mediate the febrile response to IL-1.
Taylor
A N
AN
Department of Neurobiology and Brain Research Institute, School of Medicine, University of California Los Angeles, 90095, USA. ataylor@mednet.ucl.edu
Tio
D L
DL
Yirmiya
R
R
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000437:Alcoholism / Q000503:physiopathology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood; D015232:Dinoprostone / Q000633:toxicity; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000276:immunology*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D007031:Hypothalamus / Q000737:chemistry; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced*; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D016753:Interleukin-10 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008070:Lipopolysaccharides / Q000633:toxicity; D008124:Locomotion / Q000187:drug effects; D008297:Male; D015213:Neuroimmunomodulation; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D000431:Ethanol; D000324:Adrenocorticotropic Hormone; D015232:Dinoprostone; D003345:Corticosterone