Synthesis and in vitro antibacterial activity of C-3' pyridinium cephalosporin derivatives.
The quaternary ammonium cephalosporin derivatives were prepared with various pyridines substituted at the 3 or/and 4 position. Their in vitro antibacterial activities were determined and substituent effect on pyridine nucleus was studied. Preparation of substituted pyridines are also described.
Chung
I H
IH
Biochemicals Research Center, Korea Institute of Science and Technology, Seoul. inchung@kistmail.kist.re.kr
Kim
C S
CS
Seo
J H
JH
Chung
B Y
BY
D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D011726:Pyridinium Compounds