A retrospective look at horses exhibiting unusual clinical signs after exercising on L-NAME.
Three of 5 horses exercising on L-NAME (NG-nitro-L-arginine methyl ester) exhibited unusual clinical signs towards the end of exercise bouts and post-exercise. L-NAME is a nitric oxide synthase inhibitor which blocks synthesis of nitric oxide from L-arginine. The induced absence of nitric oxide may have lead to the clinical signs observed.
Gallatin
L L
LL
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
D000818:Animals; D006736:Horses / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000009:adverse effects*; D009569:Nitric Oxide / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D012189:Retrospective Studies
D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester