Platelets: preparations, transfusion, modifications, and substitutes.
OBJECTIVE
To summarize current knowledge and recent progress pertaining to platelet concentrate preparations, modifications, and future prospects for platelet substitutes.


METHODS
Current publications identified through a search of an electronic literature database were evaluated and reviewed. Relevant data were abstracted into this article. Abstractions of the data were made depending on their relevance. This review starts with standard methods of platelet preparation and goes on to describe different modifications intended to optimize the product and increase its safety. The article concludes with a discussion of the use of hematopoietic growth factors and novel kinds of platelet components for future use.


CONCLUSIONS
Many modifications in the preparation of platelet transfusions have occurred in recent years. Platelets prepared by standard techniques contain significant numbers of donor leukocytes, which are responsible for several adverse effects. Awareness of this problem has lead to the development of effective means for their removal. Several methods to reduce the risk of viral and bacterial transmission through platelet transfusions are emerging. New technologies in the use of platelet substitutes have attempted to prolong the platelet storage potential and prevent the development of recipient alloimmunization. As the biological activities of growth factors become better understood, the clinical applications of novel recombinant products may redefine the concept of future platelet transfusions. It is important that research continues into the optimal methods for the preparation and use of platelet transfusions to provide maximal clinical benefits with minimal risk of complications.
Silberman
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Department of Pathology, Division of Immunohematology, Loyola University Medical Center, Maywood, Ill 60153, USA.
D001792:Blood Platelets / Q000187:drug effects / Q000382:microbiology / Q000502:physiology; D001802:Blood Substitutes; D015925:Cryopreservation; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D017713:Platelet Transfusion; D010983:Plateletpheresis / Q000379:methods*
D001802:Blood Substitutes; D006133:Growth Substances