title: Leishmanicidal activity of combretastatin analogues and heteroanalogues.
abstract: We have investigated the in vitro leishmanicidal activity of representative members from series II-V of combretastatin analogues and heteroanalogues. Most of them exhibited different degrees of activity against various strains of Leishmania spp. The diaryl(heteroaryl)ethane system or the more complex fused heterocyclic stilbenoids, constitute useful skeletal bases to support some kind of antiparasitic activity. Particularly, the incorporation of 2-furyl substituents led to potent antileishmanial compounds, which have been selected for in vivo testing on murine models.
authors.affiliation: Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Salamanca, Spain.
authors.forename: B
authors.initials: B
authors.lastname: del Rey
authors.forename: A C
authors.initials: AC
authors.lastname: Ramos
authors.forename: E
authors.initials: E
authors.lastname: Caballero
authors.forename: A
authors.initials: A
authors.lastname: Inchaustti
authors.forename: G
authors.initials: G
authors.lastname: Yaluff
authors.forename: M
authors.initials: M
authors.lastname: Medarde
authors.forename: A
authors.initials: A
authors.lastname: Rojas de Arias
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D001632:Bibenzyls / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D013045:Species Specificity; D013267:Stilbenes
chemical_list: D000981:Antiprotozoal Agents; D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin