Synthesis and antiviral activity of some N-benzenesulphonylbenzimidazoles.
Some N-sulphonylated benzimidazoles were synthesized as potential antiviral agents. Compound 16b and, to a lesser extent, 19b showed activity against two RNA viruses at micromolar concentrations.
Garuti
L
L
Department of Pharmaceutical Science, University of Bologna.
Roberti
M
M
Cermelli
C
C
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D029822:Enterovirus B, Human / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009109:Mumps virus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D014616:Vaccinia virus / Q000187:drug effects; D014709:Vero Cells
D000998:Antiviral Agents; D001562:Benzimidazoles