title: Glomerular filtration rate and renal volume in dogs with congenital portosystemic vascular anomalies before and after surgical ligation.
abstract: Glomerular filtration rate (GFR) and renal volume were evaluated in dogs with confirmed portosystemic vascular anomalies (PSVA) before and after surgical ligation of their PSVA. Pre- and postligation CBC, serum biochemistry, urinalysis, abdominal ultrasonography with measurement of renal volume, and per rectal scintigraphy were performed to document resolution of abnormalities consistent with portosystemic shunting. GFR was estimated by plasma 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) clearance before (n = 21) and after (n = 12) surgical correction of PSVA. Preligation 99mTc-DTPA GFR was increased (median, 5.64 mL/minute/kg; range, 3.53-8.49 mL/minute/kg; reference range, 2.83-4.47 mL/minute/kg) in 81% (17/21) of dogs. Postligation 99mTc-DTPA GFR decreased in all 12 evaluated dogs (median change = -42%; P < .001). Preligation renal volume was above the reference range for the left and right kidneys in 71% (10/14) and 69% (11/16) of dogs evaluated, respectively. Right renal volume decreased significantly (n = 5; median change, -45%; P = .03) after surgical ligation of PSVA. These findings document increased GFR and renal volume in dogs with PSVA, which may explain in part the low blood urea nitrogen and serum creatinine concentrations encountered in these dogs. Knowledge of changes in GFR associated with PSVA ligation may prove helpful in the anesthetic, drug, and dietary management of affected dogs.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA. tad6@cornell.edu
authors.forename: T A
authors.initials: TA
authors.lastname: Deppe
authors.forename: S A
authors.initials: SA
authors.lastname: Center
authors.forename: K W
authors.initials: KW
authors.lastname: Simpson
authors.forename: H N
authors.initials: HN
authors.lastname: Erb
authors.forename: J F
authors.initials: JF
authors.lastname: Randolph
authors.forename: N L
authors.initials: NL
authors.lastname: Dykes
authors.forename: A E
authors.initials: AE
authors.lastname: Yeager
authors.forename: A J
authors.initials: AJ
authors.lastname: Reynolds
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000662:veterinary; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D011168:Portal System / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D011300:Preoperative Care / Q000662:veterinary; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D014463:Ultrasonography
chemical_list: D016284:Technetium Tc 99m Pentetate