A Rational Approach to Selective Recognition of NH(4)(+) over K(+).
An ion-selective electrode (ISE) based on receptor 1 is highly selective for binding NH(4)(+) over K(+) (lg K(NH(4)(+)/K(+))=-2.6); the three imine nitrogen atoms in 1 are ideally positioned for hydrogen bonding with the tetrahedral NH(4)(+) ion. This selectivity is considerably greater than that found for commercial ISEs based on nonactin (lg K(NH(4)(+)/K(+))=-1.0).
Chin
J
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6 (Canada).
Walsdorff
C
Stranix
B
Oh
J
Chung
HJ
Park
SM
Kim
K