Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells.
The activation and subsequent proliferation of peripheral T cells requires the engagement of the T cell and a cytokine receptor, typically the IL-2 or IL-4 receptors. Critical to understanding the regulation of peripheral T cells is the knowledge of the unique contributions of each receptor to full T cell activation and cell cycle progression. Mice deficient in Stat5a and Stat5b have demonstrated the essential role that these highly related proteins play in cell cycle progression following peripheral T cell activation. Here we demonstrate that activation of the Stat5 proteins by tyrosine phosphorylation is uniquely contributed by cytokine receptor signaling and specifically does not occur through the T cell receptor complex.
Moriggl
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Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Sexl
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Piekorz
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Topham
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Ihle
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D000818:Animals; D017252:CD3 Complex / Q000276:immunology; D016207:Cytokines / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007376:Interleukin-2 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D051379:Mice; D008894:Milk Proteins; D010766:Phosphorylation; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000502:physiology; D019948:Receptors, Interleukin-4 / Q000502:physiology; D050799:STAT5 Transcription Factor; D013601:T-Lymphocytes / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*
D017252:CD3 Complex; D016207:Cytokines; D004268:DNA-Binding Proteins; D007376:Interleukin-2; D008894:Milk Proteins; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D019948:Receptors, Interleukin-4; D050799:STAT5 Transcription Factor; C494093:Stat5a protein, mouse; C494096:Stat5b protein, mouse; D015534:Trans-Activators; D015847:Interleukin-4; D004247:DNA