Preparation and properties of totally synthetic immunogens.
Although the induction of antibodies and T cells by synthetic peptides representing defined antigenic determinants is a routine laboratory procedure, their use as vaccines has not yet been generally realised. There are a number of reasons for this and paramount is the limitation of valency which affects not only immunogenicity, but also the coverage of the antigenic universe. This paper is a review of our own work in which we have assembled synthetic peptides into multivalent artificial proteins and then examined their immunological properties.
Jackson
D C
DC
Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia. d.jackson@microbiology.unimelb.edu.au
Fitzmaurice
C J
CJ
Brown
L E
LE
Zeng
W
W
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology; D014614:Vaccines, Synthetic
D000939:Epitopes; D014614:Vaccines, Synthetic