title: A population-based study on tetanus antitoxin levels in The Netherlands.
abstract: We assessed the tetanus immunity of the general Dutch population and of religious groups refusing vaccination by means of population-based study to evaluate the effect of tetanus vaccination. More than 95% of those born after the introduction of routine vaccination had tetanus antitoxin levels above the minimum protective level. After the sixth vaccination, a fall in tetanus antitoxin levels occurred. Nevertheless, immunisation in accordance with the routine programme most likely induces protection for much longer than two decades. Not only many members of religious groups who refuse vaccination, but also many adults born before the introduction of vaccination lack tetanus immunity. These cohorts might benefit most from (re)vaccination.
authors.affiliation: Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: de Melker
authors.forename: S
authors.initials: S
authors.lastname: van den Hof
authors.forename: G A
authors.initials: GA
authors.lastname: Berbers
authors.forename: N J
authors.initials: NJ
authors.lastname: Nagelkerke
authors.forename: H C
authors.initials: HC
authors.lastname: Rümke
authors.forename: M A
authors.initials: MA
authors.lastname: Conyn-van Spaendonck
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012737:Sex Factors; D013743:Tetanus Antitoxin / Q000097:blood*; D013745:Tetanus Toxoid / Q000276:immunology; D014611:Vaccination
chemical_list: D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid