Effects of recombinant nitrophorin-2 nitric oxide complex on vascular smooth muscle.
Nitrophorin-2, isolated from the salivary gland of the blood-sucking insect Rhodnius prolixus, is a nitric oxide (NO) binding protein. We investigated the effects of recombinant nitrophorin-2 NO complex on vascular smooth muscle. The course of relaxation was relative to released NO from recombinant nitrophorin-2 NO complex. Our data suggested nitrophorin-2 was tightly adhesive to the membranes to transport NO into the cell during the insect sting.
Kaneko
Y
Y
Department of Medical Zoology, School of Medicine, Mie University, Japan.
Shojo
H
H
Yuda
M
M
Chinzei
Y
Y
D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D006420:Hemeproteins / Q000737:chemistry / Q000494:pharmacology*; D019476:Insect Proteins / Q000737:chemistry / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D011994:Recombinant Proteins / Q000737:chemistry / Q000494:pharmacology; D012471:Salivary Proteins and Peptides / Q000737:chemistry / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
D006420:Hemeproteins; D019476:Insect Proteins; D011994:Recombinant Proteins; D012471:Salivary Proteins and Peptides; D014665:Vasodilator Agents; C090560:nitrophorin; D009569:Nitric Oxide; D006152:Cyclic GMP