title: Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis.
abstract: BACKGROUND
  Lymphocytic gastritis is characterised by an accumulation of lymphocytes in the surface epithelium of the stomach. Lymphocytic gastritis has been linked to coeliac disease and Helicobacter pylori infection.
  
  
  OBJECTIVE
  To determine whether H pylori eradication leads to resolution of the lymphocytic infiltrate and clinical improvement in patients with lymphocytic gastritis, and to determine their HLA status.
  
  
  METHODS
  The Leeds Dyspepsia Questionnaire (LDQ) was administered to 13 patients with lymphocytic gastritis. H pylori serology, (13)C urea breath test (UBT), and upper gastrointestinal endoscopy with sampling of the duodenum, antrum, and corpus were done in all cases and the HLA status was determined. Eleven patients had at least one positive test for H pylori. Patients with lymphocytic gastritis and H pylori infection were treated with a one week course of omeprazole, clarithromycin, and metronidazole. Gastric and duodenal intraepithelial lymphocyte (IEL) counts were performed, along with histological assessment of gastric and duodenal biopsies before and after H pylori eradication.
  
  
  RESULTS
  Two months after treatment there was a significant reduction in gastric IEL counts in both antrum and corpus. There was no significant change in duodenal IEL counts before and after eradication. According to the Sydney grading there was significant improvement in corpus inflammation after eradication. The patients histologically H pylori positive before treatment became H pylori negative. Dyspepsia scores also improved significantly after treatment.
  
  
  CONCLUSIONS
  H pylori eradication treatment in patients with lymphocytic gastritis causes significant improvement in the gastric IEL infiltrate, corpus inflammation, and dyspeptic symptoms. H pylori serology is frequently positive when histology and UBT are negative. Lymphocytic gastritis may represent a specific immune response to H pylori infection.
authors.affiliation: Centre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hayat
authors.forename: D S
authors.initials: DS
authors.lastname: Arora
authors.forename: M F
authors.initials: MF
authors.lastname: Dixon
authors.forename: B
authors.initials: B
authors.lastname: Clark
authors.forename: S
authors.initials: S
authors.lastname: O'Mahony
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004415:Dyspepsia / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D006683:HLA-DQ Antigens / Q000097:blood; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016480:Helicobacter pylori; D006650:Histocompatibility Testing; D006801:Humans; D018655:Lymphocyte Count; D008218:Lymphocytosis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D006683:HLA-DQ Antigens