title: A case of renal juxtaglomerular cell tumor: usefulness of segmental sampling to prove autonomic secretion of the tumor.
abstract: A 27-year-old female patient had been treated for hypertension with conventional therapy for years, because renal vein renin levels failed to show lateralization in renal venous samplings and a renal juxtaglomerular cell tumor (RJGCT) had gone undiagnosed. Abdominal computed tomography revealed a mass at the middle of the right kidney. The right renal venogram demonstrated distinct segmental veins from the upper pole and from the middle and lower poles in the right kidney. On segmental renin sampling from each renal vein, the plasma renin concentration (PRC) of the segmental veins from the middle and lower poles was higher than that from other sites. We diagnosed RJGCT of the right kidney and performed right-sided nephrectomy. After the resection, the PRC rapidly decreased. Immunohistochemical studies using antihuman renin antibodies revealed positive staining of the tumor cells. It is an important strategy to make a segmental sampling at the site as close as possible to the RJGCT.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Koriyama
authors.forename: M
authors.initials: M
authors.lastname: Kakei
authors.forename: K
authors.initials: K
authors.lastname: Yaekura
authors.forename: M
authors.initials: M
authors.lastname: Nakazaki
authors.forename: S
authors.initials: S
authors.lastname: Morimitsu
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: C
authors.initials: C
authors.lastname: Tei
authors.forename: K
authors.initials: K
authors.lastname: Ueno
authors.forename: N
authors.initials: N
authors.lastname: Miyazono
authors.forename: M
authors.initials: M
authors.lastname: Nakajo
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D009392:Nephrectomy; D010690:Phlebography; D012082:Renal Veins / Q000000981:diagnostic imaging; D012083:Renin / Q000097:blood*
chemical_list: D012083:Renin