Replacement of internal protein genes, with the exception of the matrix, in equine 1 viruses by equine 2 influenza virus genes during evolution in nature.
To establish the evolutionary association between the equine 1 H7 HA and M genes, phylogenetic analyses of the six internal gene segments of equine 1 influenza viruses (H7N7 subtype) were performed using partial nucleotide sequences. The results demonstrated that five internal genes (PBI, PB2, PA, NP and NS) of equine 1 viruses isolated after 1964 were replaced by those of equine 2 H3N8 viruses. However, the M gene was maintained during the evolution of these equine 1 viruses. These findings suggest a functional association between equine H7 HA and M gene products, most likely M2 protein.
Ito
T
T
Department of Veterinary Public Health, Faculty of Agriculture, Tottori University, Japan.
Kawaoka
Y
Y
Ohira
M
M
Takakuwa
H
H
Yasuda
J
J
Kida
H
H
Otsuki
K
K
D000818:Animals; D019143:Evolution, Molecular; D006734:Horse Diseases / Q000235:genetics / Q000821:virology*; D006736:Horses; D006863:Hydrogen-Ion Concentration; D009980:Influenza A virus / Q000235:genetics*; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000662:veterinary*; D010802:Phylogeny; D011487:Protein Conformation; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins