Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity.
Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.
Coley
S C
SC
Department of Neuroradiology, University College London Medical School, England.
Porter
D A
DA
Calamante
F
F
Chong
W K
WK
Connelly
A
A
D000755:Anemia, Sickle Cell / Q000188:drug therapy; D016026:Bone Marrow Transplantation; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001931:Brain Mapping; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D004058:Diffusion; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D020258:Neurotoxicity Syndromes / Q000175:diagnosis*; D016511:Severe Combined Immunodeficiency / Q000188:drug therapy
D007166:Immunosuppressive Agents; D016572:Cyclosporine