Arg-gingipain inhibition and anti-bacterial activity selective for Porphyromonas gingivalis by malabaricone C.
Effects of malabaricon C, isolated from nutmeg (Myristica fragrans), on Arg-gingipain activity and growth of several kinds of anaerobic and aerobic microorganisms were investigated. Malabaricone C irreversibly inhibited Arg-gingipain by 50% at a concentration of 0.7 microgram/ml and selectively suppressed Porphyromomas gingivalis growth.
Shinohara
C
C
Sagami Chemical Research Center, Kanagawa, Japan.
Mori
S
S
Ando
T
T
Tsuji
T
T
D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003546:Cysteine Endopeptidases / Q000187:drug effects*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D000080867:Gingipain Cysteine Endopeptidases; D006388:Hemagglutinins / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D018829:Adhesins, Bacterial; D000900:Anti-Bacterial Agents; D015853:Cysteine Proteinase Inhibitors; D000080867:Gingipain Cysteine Endopeptidases; D006388:Hemagglutinins; D012118:Resorcinols; C071787:malabaricone C; D003546:Cysteine Endopeptidases