title: Single-cell models: promise and limitations.
abstract: This article describes the development of single-cell models, their uses and accomplishments, the barriers to the greater adoption, and a perspective on challenges to the biochemical engineering community where the single-cell model approach may be used advantageously. In particular, it may become an important tool in relating genomic information to cellular regulation and dynamics.
authors.affiliation: School of Chemical Engineering, Cornell University, Ithaca, NY 14853-5201, USA. mls@cheme.cornell.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Shuler
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D006801:Humans; D008954:Models, Biological