Recent developments and applications of liquid-phase strategies in organic synthesis.
Chemistry on soluble polymer supports, termed liquid-phase organic synthesis, is developing into an increasingly viable alternative or adjunct to the classical solid-phase approach across the broad spectrum of polymer-supported organic chemistry. Recent advances in the field include the use of soluble polymers in the combinatorial synthesis of peptide and small-molecule libraries, as catalyst and reagent supports, and as functionalized polymer-quench reagents for purifying solution-phase combinatorial libraries.
Wentworth
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Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA. paulw@scripps.edu
D002625:Chemistry, Organic / Q000639:trends*; D019151:Peptide Library; D011108:Polymers / Q000138:chemical synthesis*
D019151:Peptide Library; D011108:Polymers