title: [The pharmacological correction of hemodynamics during the simulation of the early period of adaptation to weightlessness].
abstract: Investigations of volunteered subjects in whom antiorthostatic hypokinesia was modeled by tilting the cranial end of the body by -15 degrees were to answer whether pharmacological countermeasures of the vestibular/autonomous syndrome (motion sickness, sea sickness) alter the orthostatic tolerance and cardiovascular parameters. As was stated, the drugs allow controlled correction of hemodynamic resistance to the head-down tilt. Ephedrine, phencarol, ephedrine combined with scopolamine and pipolphen, and stugeron normalized cerebral circulation. Medicaments were unable to moderate the sympathoadrenal reaction to the head-down tilt; however, blood concentrations of catecholamines were significantly lower than in the control. The greatest effect was achieved using ephedrine and ephedrine plus pipolphen.
authors.forename: V S
authors.initials: VS
authors.lastname: Shashko
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Modin
authors.forename: S L
authors.initials: SL
authors.lastname: Il'ina
authors.forename: V V
authors.initials: VV
authors.lastname: Sabaev
authors.forename: A V
authors.initials: AV
authors.lastname: Shashkov
authors.forename: M G
authors.initials: MG
authors.lastname: Potapov
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D004452:Echocardiography / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010992:Plethysmography, Impedance / Q000187:drug effects; D018667:Tilt-Table Test / Q000379:methods / Q000706:statistics & numerical data; D013997:Time Factors; D018474:Weightlessness Simulation / Q000379:methods / Q000706:statistics & numerical data; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes