title: Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds.
abstract: In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date.
authors.affiliation: The Salk Institute for Biological Studies, Gene expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037-1099, USA.
authors.forename: K
authors.initials: K
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Yonei-Tamura
authors.forename: J C
authors.initials: JC
authors.lastname: Izpisúa Belmonte
mesh_terms: D000595:Amino Acid Sequence; D000825:Animal Structures / Q000378:metabolism*; D000818:Animals; D030161:Avian Proteins; D005123:Eye / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D015027:Zebrafish; D029961:Zebrafish Proteins
chemical_list: D030161:Avian Proteins; D020825:T-Box Domain Proteins; C103172:T-box transcription factor 5; C491196:TBX4 protein, Gallus gallus; D029961:Zebrafish Proteins; C491194:tbx4 protein, zebrafish