Metallo-beta-lactamase: structure and mechanism.
This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.
Wang
Z
Z
The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.
Fast
W
W
Valentine
A M
AM
Benkovic
S J
SJ
D000595:Amino Acid Sequence; D002384:Catalysis; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016415:Sequence Alignment; D013329:Structure-Activity Relationship; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism*
D001618:beta-Lactamases