High IL-18 (interferon-gamma inducing factor) concentration in a purine nucleoside phosphorylase deficient patient.
The plasma concentration of IL-18 (interferon-gamma inducing factor) was severely increased in a 3 year old boy with purine nucleoside phosphorylase (PNP) deficiency. The presence and activity of IL-18 were confirmed by immunoblotting and bioassay, respectively. These results suggest that IL-18 may be abundantly produced and secreted into plasma by PNP deficient macrophages in PNP deficiency.
Yamamoto
T
T
Third Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.
Moriwaki
Y
Y
Matsui
K
K
Takahashi
S
S
Tsutsui
H
H
Yoshimoto
T
T
Okamura
H
H
Nakanishi
K
K
Kurosawa
Y
Y
Yamaguchi
S
S
Sasaki
Y
Y
Higashino
K
K
D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008264:Macrophages / Q000201:enzymology; D008297:Male; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*
D015415:Biomarkers; D020382:Interleukin-18; D011683:Purine-Nucleoside Phosphorylase