Molecular controls of radiation-induced apoptosis in the neonatal rat kidney.
The incidence of cell death due to radiation was examined in a neonatal in vivo model. Differences in the induction of apoptosis, amount of cell proliferation, S-phase cell death, Bcl-2 and p-53 expression could best be explained by the differences in the zonal state of differentiation and development. The present in vivo model may thus be useful in testing radiation therapies for renal cancer.
Gobé
G
G
Department of Pathology, University of Queensland Medical School, Brisbane, Australia. g.gobe@mailbox.uq.edu.au
Schoch
E
E
Leighton
J
J
D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects*; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002467:Cell Nucleus / Q000737:chemistry / Q000648:ultrastructure; D002843:Chromatin; D003513:Cycloheximide / Q000494:pharmacology; D007668:Kidney / Q000737:chemistry / Q000166:cytology*; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis* / Q000096:biosynthesis; D051381:Rats; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000096:biosynthesis
D002843:Chromatin; D011500:Protein Synthesis Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D003513:Cycloheximide