Im-trityl protection of histidine.
A rational attempt to prepare FmocHis(piTrt)OH regiospecifically gave in fact the well-known tau-trityl isomer, and experiments with model systems indicate that the prospects for access to pi-trityl histidine derivatives, which would be of great value for the racemization-free synthesis of histidine-containing peptides, are poor.
Harding
S J
SJ
The Dyson Perrins Laboratory, University of Oxford, UK.
Jones
J H
JH
Sabirov
A N
AN
Samukov
V V
VV
D006639:Histidine / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D014320:Triphenylmethyl Compounds; D006639:Histidine; C003723:trityl chloride