Colonic adenocarcinoma metastatic to the thyroid gland: a case report with immunohistochemical investigation.
Clinically evident metastases of carcinomas to the thyroid gland are rare, particularly from a colorectal primary tumor. We present a case of colonic adenocarcinoma metastatic to the thyroid gland with histopathologic and immunohistochemical findings. A 68-year-old woman with a history of Dukes' stage B colon carcinoma presented a mass in the thyroid gland. The tumor was confirmed to be metastatic adenocarcinoma from the colon. The immunohistochemical findings demonstrated positive staining for cytokeratin 20, low-molecular-weight cytokeratin, villin and carcinoembryonic antigen, but stains were negative for cytokeratin 7 and thyroglobulin.
Kim
C H
CH
Department of Pathology, Korea University Guro Hospital, Seoul.
Park
Y W
YW
Ayala
A G
AG
Ro
J Y
JY
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D000368:Aged; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D008840:Microfilament Proteins / Q000032:analysis; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D016606:Thyroid Nodule / Q000737:chemistry / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D002352:Carrier Proteins; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D008840:Microfilament Proteins; C026615:villin; D007633:Keratins