Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass.
Cardiopulmonary bypass is often followed by pulmonary dysfunction as assessed by measuring the alveolar-arterial oxygenation gradient, intrapulmonary shunt, degree of pulmonary edema, pulmonary compliance, and pulmonary vascular resistance. It is also regarded as a risk factor for development of acute respiratory distress syndrome. On the other hand, cardiopulmonary bypass is associated with a whole body inflammatory response, which involves activation of complement, leukocytes, and endothelial cells with secretion of cytokines, proteases, arachidonic acid metabolites, and oxygen free radicals. Leukocyte adhesion to microvascular endothelium, leukocyte extravasation, and tissue damage are the final steps. Although the inflammatory response to cardiopulmonary bypass often remains at subclinical levels, it can also lead to major organ dysfunction and multiple organ failure. This review article summarizes the recent literature on the molecular and cellular mechanisms involved in the phenomenon of pulmonary dysfunction after cardiopulmonary bypass. It also summarizes reports on the prevalence and mortality of acute respiratory distress syndrome after cardiac surgery.
Asimakopoulos
G
G
Cardiothoracic Unit, Imperial College School of Medicine at Hammersmith Hospital, London, England.
Smith
P L
PL
Ratnatunga
C P
CP
Taylor
K M
KM
D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006801:Humans; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy