title: Differential effects of lipopolysaccharide and cholecystokinin on sucrose intake and palatability.
abstract: The differential effects of CCK and lipopolysaccharide (LPS) on sucrose intake and palatability were examined. Rats were injected with LPS (200 microg/kg ip) or NaCl (0.9%, vehicle) and 2 h later received a second injection of either CCK (8 microg/kg ip) or NaCl. In experiment 1, sucrose (0.3 M) intake was monitored for 1 h on three different test days 72 h apart, while in experiment 2, palatability was assessed by means of the taste reactivity test (TRT) on two separate days (72 h apart). In the TRT, orofacial and somatic responses to brief (30 s) intraoral infusions of sucrose were recorded and analyzed for response frequency. Singly, LPS and CCK reduced sucrose intake, with a more pronounced effect from combined LPS and CCK. LPS by itself did not alter sucrose palatability, as evidenced by continuous high levels of ingestive responding. In contrast, CCK-treated rats displayed a pattern of responding indicative of satiety, as did the combined LPS-CCK-treated rats. These results suggest that LPS does not induce hypophagia by altering palatability.
authors.affiliation: Neuroscience Program and Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada. skcross@julian.uwo.ca
authors.forename: S K
authors.initials: SK
authors.lastname: Cross-Mellor
authors.forename: W D
authors.initials: WD
authors.lastname: Kent
authors.forename: K P
authors.initials: KP
authors.lastname: Ossenkopp
authors.forename: M
authors.initials: M
authors.lastname: Kavaliers
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D004357:Drug Synergism; D004435:Eating; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D013395:Sucrose; D002766:Cholecystokinin