title: Xenopus frizzled-2 is expressed highly in the developing eye, otic vesicle and somites.
abstract: Wnts are secreted signaling molecules implicated in a large number of developmental processes. Frizzled proteins have been identified as likely receptors for Wnt ligands in vertebrates and invertebrates. To assess the endogenous role of frizzled proteins during the development of Xenopus laevis, we have identified several frizzled homologs. Here we report the cloning and expression of Xenopus frizzled-2 (xfz2). Xfz2 shows high sequence homology to rat and human frizzleds-2. It is expressed in the developing embryo from late gastrula stages onward. Xfz2 has a wide domain of expression but is concentrated in the eye anlage, otic vesicle, and developing somites.
authors.affiliation: Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Deardorff
authors.forename: P S
authors.initials: PS
authors.lastname: Klein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004423:Ear / Q000196:embryology*; D005123:Eye / Q000196:embryology*; D051157:Frizzled Receptors; D015870:Gene Expression; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D009672:Notochord / Q000196:embryology / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D019170:Somites / Q000378:metabolism*; D013997:Time Factors; D014981:Xenopus; D029867:Xenopus Proteins
chemical_list: C489744:FZD2 protein, Xenopus; C489742:FZD2 protein, human; D051157:Frizzled Receptors; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter; D029867:Xenopus Proteins