Regulatory T cells and inflammatory bowel disease.
Recent studies have identified interleukin 10 as a differentiation factor for a novel subset of immune suppressive regulatory T cells. Here, Hervé Groux and Fiona Powrie discuss the role that these cells play in the regulation of immune responses to enteric antigens and suggest that a deficiency in these cells might be involved in the pathogenesis of inflammatory bowel disease.
Groux
H
H
INSERM U343, Hôpital de l'Archet, Route de Saint Antoine de Ginestières, 06200 Nice, France. groux@unice.fr
Powrie
F
F
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D016753:Interleukin-10 / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology
D016753:Interleukin-10