title: Structure and mechanism of ATP-dependent proteases.
abstract: A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA.
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: A N
authors.initials: AN
authors.lastname: Lupas
authors.forename: D
authors.initials: D
authors.lastname: Finley
mesh_terms: D000255:Adenosine Triphosphate; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D018832:Molecular Chaperones; D000255:Adenosine Triphosphate; D012697:Serine Endopeptidases