title: Synthesis and in vitro cytotoxicity of 1-azaanthraquinone-3-carboxamides.
abstract: Five 1-azaanthraquinone-3-carboxamides were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The most active compound, 7b, exhibited cytotoxic activity comparable to doxorubicin.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, Korea. medchem@trut.chungbuk.ac.kr
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: S I
authors.initials: SI
authors.lastname: Yang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D002452:Cell Count; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000577:Amides; D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin