A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer.
Colorectal carcinoma is an important cause of cancer morbidity and mortality. 5-fluorouracil has been the major chemotherapeutic agent for the treatment of colorectal carcinoma for the past four decades. This regimen is noncurative, and its impact on survival is unclear. Attempts at identifying more effective chemotherapeutic agents for colorectal cancer have yielded oral formulations and prodrugs of 5-fluorouracil with apparently equivalent efficacy. Specific thymidylate synthase inhibitors are now available. Platinum analogues with activity in colorectal carcinoma, and no cross-resistance to the antimetabolites have also been developed. The topoisomerase I inhibitors represent a new class of agents with a novel mechanism of action. These agents are in phase II and Phase III clinical trials, others have been approved for clinical use within the last 3 years.
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Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005472:Fluorouracil / Q000031:analogs & derivatives; D005971:Glutamates / Q000627:therapeutic use; D006147:Guanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D000068437:Pemetrexed; D017671:Platinum Compounds / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D005641:Tegafur / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D000970:Antineoplastic Agents; D005971:Glutamates; D017671:Platinum Compounds; D011725:Pyridines; D011799:Quinazolines; D013876:Thiophenes; D000068437:Pemetrexed; D003841:Deoxycytidine; D005641:Tegafur; C073482:eniluracil; D014498:Uracil; D006147:Guanine; D000069287:Capecitabine; C068874:raltitrexed; D005472:Fluorouracil; C104201:gimeracil