title: Organoapatite growth on an orthopedic alloy surface.
abstract: We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
authors.affiliation: Department of Materials Science and Engineering and Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Hwang
authors.forename: K
authors.initials: K
authors.lastname: Jaeger
authors.forename: J
authors.initials: J
authors.lastname: Hancock
authors.forename: S I
authors.initials: SI
authors.lastname: Stupp
mesh_terms: D001031:Apatites / Q000737:chemistry; D016723:Bone Remodeling; D018786:Bone Substitutes; D008854:Microscopy, Electron; D009985:Orthopedics / Q000379:methods*; D019265:Spectroscopy, Near-Infrared; D014025:Titanium / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D014025:Titanium