[Evaluation of serum D-arabinitol as a diagnostic test for invasive candidiasis in the urinary tract].
OBJECTIVE
Serum D-arabinitol were measured 1) differentiate between invasive candidasis and colonization in the urinary tract 2) evaluate its efficacy for early diagnosis and treatment monitor of invasive candidasis.


METHODS
1. Laboratory study: Serum D-arabinitol levels were measured in both candida infected rats and control rats. The cut-off levels were determined by the comparison of the two groups. Serum levels of D-arabinitol and CAND-TEC were measured every day per after candida was inoculated. Furthermore, the candida infected rats were treated with fluconazole (0.5 mg/body), and the changes of serum levels of D-arabinitol and CAND-TEC were observed. 2. Clinical study: Serum D-arabinitol, CAND-TEC and beta-D-glucan were measured to evaluate its efficacy for early diagnosis in the group with candida positive urine cultures.


RESULTS
The cut-off levels of D-arabinitol were set 2.0 micrograms/ml, at which sensitivity was high, and specificity acceptable. The serum level of D-arabinitol raised as candida infection was established and lowered after treatment was started. CAND-TEC was negative in all materials. High levels of D-arabinitol and beta-D-glucan was measured in invasive candidasis, and lowered++ by fluconazole treatment. CAND-TEC had a low positive rate.


CONCLUSIONS
Serum D-arabinitol level was sensitive for the early diagnosis of invasive candidasis and its efficacy as a monitor for treatment effects was implied.
Abe
T
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Department of Urology, Tokai University School of Medicine.
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002177:Candidiasis / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003955:Diagnostic Tests, Routine; D007674:Kidney Diseases / Q000175:diagnosis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013402:Sugar Alcohols / Q000097:blood*; D014552:Urinary Tract Infections / Q000175:diagnosis*
D015415:Biomarkers; D013402:Sugar Alcohols; C014999:arabitol