title: Implementation of ICP-MS protocols for uranium urinary measurements in worker monitoring.
abstract: The uranium concentration in human urine spiked with natural uranium and rat urine containing metabolized depleted uranium was determined by ICP-MS. The use of ICP-MS was investigated without any chemical treatment or after the different stages of a purification protocol currently carried out for routine monitoring. In the case of spiked urine, the measured uranium concentrations were consistent with those certified by an intercomparison network in radiotoxicological analysis (PROCORAD) and with those obtained by alpha spectrometry in the case of the urine containing metabolized uranium. The quantitative information which could be obtained in the different protocols investigated shows the extent to which ICP-MS provides greater flexibility for setting up appropriate monitoring approaches in radiation protection routines and accidental situations. This is due to the combination of high sensitivity and the accuracy with which traces of uranium in urine can be determined in a shorter time period. Moreover, it has been shown that ICP-MS measurement can be used to quantify the 235U isotope, which is useful for characterizing the nature of the uranium compound, but difficult to perform using alpha spectrometry.
authors.affiliation: Institut de Protection et de Sûreté Nucléaire, Département de Protection de la santé de l'Homme et de Dosimétrie, IPSN, Fontenay-aux-Roses, France. nicolas.baglan@ipsn.fr
authors.forename: N
authors.initials: N
authors.lastname: Baglan
authors.forename: C
authors.initials: C
authors.lastname: Cossonnet
authors.forename: F
authors.initials: F
authors.lastname: Trompier
authors.forename: J
authors.initials: J
authors.lastname: Ritt
authors.forename: P
authors.initials: P
authors.lastname: Bérard
mesh_terms: D000818:Animals; D006801:Humans; D016273:Occupational Exposure; D011834:Radiation Monitoring / Q000379:methods* / Q000592:standards; D051381:Rats; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014501:Uranium / Q000493:pharmacokinetics / Q000652:urine*
chemical_list: D014501:Uranium