title: Herpes simplex-associated erythema multiforme (HAEM): a clinical therapeutic dilemma.
abstract: Erythema multiforme of the mouth is an acute vesiculo-ulcerative lesion, which presents a diagnostic and therapeutic challenge to the clinician. Herpes simplex is described as the most frequent cause of this disease. Controversy exists in the literature as to the definition of oral erythema multiforme and the role of systemic corticosteroids in its treatment. Recent treatment protocols advocate the use of systemic acyclovir, especially in cases triggered by the herpes simplex virus. Two cases of successful treatment of oral erythema multiforme with systemic corticosteroids after acyclovir treatment had failed are presented.
authors.affiliation: Department of Oral Medicine, Oral Diagnosis, Oral Radiology, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Katz
authors.forename: A
authors.initials: A
authors.lastname: Livneh
authors.forename: J
authors.initials: J
authors.lastname: Shemer
authors.forename: Y L
authors.initials: YL
authors.lastname: Danon
authors.forename: B
authors.initials: B
authors.lastname: Peretz
mesh_terms: D000208:Acute Disease; D002648:Child; D004359:Drug Therapy, Combination; D004892:Erythema Multiforme / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006560:Herpes Labialis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D012074:Remission Induction; D013283:Stomatitis, Herpetic / Q000175:diagnosis* / Q000188:drug therapy; D017211:Treatment Failure