title: Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease.
abstract: We studied the effect of antileukotriene therapy for the relief of sinus symptoms in patients with aspirin triad disease (ATD). We reviewed the charts of 18 ATD patients who had received antileukotriene therapy. All patients had undergone previous sinus surgery. We then designed a questionnaire to determine the level of each patient's symptoms of chronic rhinosinusitis before and after antileukotriene therapy. Responses were converted to symptom scores. For each patient, the role of therapy in the relief of sinus symptoms was evaluated in three ways: by total symptom scores, by self-reports of overall benefit, and by findings on endoscopic nasal examination. Fifteen of the 18 patients completed the questionnaire. Symptom scores for both major and minor symptoms indicated that nine patients had improved following antileukotriene therapy; three other patients reported some overall benefit from therapy, despite no improvement in their symptom scores. Endoscopic nasal examination findings were consistent with the reports of overall benefit. We conclude that antileukotriene therapy is an effective treatment for most patients whose symptoms of chronic rhinosinusitis persist following sinus surgery.
authors.affiliation: Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA.
authors.forename: S O
authors.initials: SO
authors.lastname: Ulualp
authors.forename: B M
authors.initials: BM
authors.lastname: Sterman
authors.forename: R J
authors.initials: RJ
authors.lastname: Toohill
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017060:Patient Satisfaction; D048448:Phenylcarbamates; D012189:Retrospective Studies; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013449:Sulfonamides; D011795:Surveys and Questionnaires; D013577:Syndrome; D014105:Tosyl Compounds / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; D001241:Aspirin; C062735:zafirlukast