title: Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma.
abstract: Intubation granuloma of the larynx is an iatrogenic disease which is induced by endotracheal intubation. It has basically been managed by conservative medical treatment with observation. Surgical excision can be considered as a last resort due to the high recurrence rate which subjects the patients to repeated anaesthesia. The purpose of this study is to evaluate the therapeutic effect of topical steroid in intubation granuloma, comparing the results of conservative medical treatment with, or without, surgery (Group I, 14 patients) and inhalant therapy with topical budesonide (Group II, 20 patients). In Group I, complete disappearance of granuloma occurred in six cases within a year (42.8 per cent) with conservative therapy only. Microlaryngeal surgery was performed on the eight cases of persisting granuloma after conservative therapy for a year, resulting in two cases of recurrence. In Group II, the granuloma disappeared completely in 85 per cent within six months and in 95 per cent within 12 months without any remarkable side-effects. We concluded that intubation granuloma of the larynx could be treated with topical inhalant steroid as the first choice of therapy rather than other medical treatment or surgical intervention.
authors.affiliation: Department of Otolaryngology, College of Medicine, Pusan National University, Korea.
authors.forename: H J
authors.initials: HJ
authors.lastname: Roh
authors.forename: E K
authors.initials: EK
authors.lastname: Goh
authors.forename: K M
authors.initials: KM
authors.lastname: Chon
authors.forename: S G
authors.initials: SG
authors.lastname: Wang
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019819:Budesonide / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006102:Granuloma, Laryngeal / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D019819:Budesonide