title: Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow.
abstract: Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two-dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Bao
authors.forename: C R
authors.initials: CR
authors.lastname: Guttmann
authors.forename: J P
authors.initials: JP
authors.lastname: Mugler
authors.forename: J R
authors.initials: JR
authors.lastname: Brookeman
authors.forename: L P
authors.initials: LP
authors.lastname: Panych
authors.forename: R A
authors.initials: RA
authors.lastname: Kraft
authors.forename: K
authors.initials: K
authors.lastname: Oshio
authors.forename: D
authors.initials: D
authors.lastname: Jaramillo
authors.forename: F A
authors.initials: FA
authors.lastname: Jolesz
authors.forename: D S
authors.initials: DS
authors.lastname: Williamson
authors.forename: R V
authors.initials: RV
authors.lastname: Mulkern
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000737:chemistry*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007719:Knee Joint / Q000033:anatomy & histology / Q000737:chemistry; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D012016:Reference Values; D013113:Spin Labels; D014280:Triglycerides / Q000032:analysis
chemical_list: D008055:Lipids; D013113:Spin Labels; D014280:Triglycerides