Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis.
A rapid and simple approach to the chiral separation of sympathomimetic drugs with amino alcohol structure by ligand exchange capillary electrophoresis is described. An N-(2-hydroxyoctyl)-L-4-hydroxyproline/copper(II) complex is used as chiral selector. Thirteen sympathomimetics were resolved, nine with baseline resolution. The influence of pH and composition of the electrolyte on resolution was investigated. The optimal pH for complexation of these amino alcohols was found to be 12.
Schmid
M G
MG
Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
Laffranchini
M
M
Dreveny
D
D
Gübitz
G
G
D019075:Electrophoresis, Capillary / Q000379:methods*; D004809:Ephedrine / Q000031:analogs & derivatives; D004983:Ethanolamines / Q000032:analysis; D006909:Hydroxyproline / Q000031:analogs & derivatives; D015394:Molecular Structure; D010627:Phenethylamines / Q000032:analysis; D013566:Sympathomimetics / Q000302:isolation & purification*; D013578:Synephrine / Q000031:analogs & derivatives / Q000032:analysis
D004983:Ethanolamines; C115824:N-(2-hydroxyoctyl)-4-hydroxyproline; D010627:Phenethylamines; D013566:Sympathomimetics; C026055:oxilofrine; D004809:Ephedrine; D013578:Synephrine; D006909:Hydroxyproline; C084810:bamethan