Danazol and multiple hepatic adenomas: peculiar clinical findings in an acromegalic patient.
Hepatic adenomas are rare tumors; they have been associated with the use of anabolic steroids. Acromegaly increases the overall risk of neoplasms. We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis. Treatment of acromegaly with octreotide, followed by successful selective pituitary adenomectomy, stabilized the number and the size of the liver tumors. We suggest that oversecretions of GH and IGF-I were strong promoting factors for liver tumorigenesis in this patient.
de Menis
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Department of Internal Medicine, Ospedale Regionale, Treviso, Italy. EDEMENIS@ULSS.TV.IT
Tramontin
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D000172:Acromegaly / Q000150:complications* / Q000628:therapy; D000236:Adenoma / Q000139:chemically induced* / Q000601:surgery; D000328:Adult; D003613:Danazol / Q000009:adverse effects*; D004965:Estrogen Antagonists / Q000009:adverse effects*; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007889:Leiomyoma / Q000188:drug therapy; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000601:surgery; D015282:Octreotide / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy
D004965:Estrogen Antagonists; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D003613:Danazol; D015282:Octreotide