title: Long-term effect of endoscopic transthoracic sympathicotomy on heart rate variability and QT dispersion in severe angina pectoris.
abstract: We evaluated short and long-term effects on QT dispersion and autonomic balance after endoscopic transthoracic sympathicotomy (ETS). Heart rate variability (HRV) reflects autonomic balance of the heart. QT dispersion is a marker of cardiac electrical instability in patients with ischemic heart disease. Holter recordings for 24 h and a twelve-lead ECG were made prior to, 1 month, 1 year and 2 years after ETS. HRV was analysed in time domain and spectral analysis was performed during controlled respiration in supine position and during head up tilt. Dispersion of QT time and QTc were calculated. Of 88 patients, 62 (60) were eligible for HRV (QT-dispersion) analysis after 1 month, 39 (38) patients after 1 year and 23 (24) patients after 2 years. The HRV analysis showed a significant change of indices reflecting sympatho-vagal balance indicating significantly reduced sympathetic (LF) and increased vagal (HF, rMSSD) tone. These changes still persisted after 2 years. Global HRV increased over time with significant elevation of SDANN after 2 years. QT dispersion was significantly reduced 1 month after surgery and the dispersion was further diminished 2 years later.
  
  
  CONCLUSIONS
  ETS changed HRV and QT dispersion which could imply reduced risk for malignant arrhythmias and death after ETS.
authors.affiliation: Department of Medicine, Borås County Hospital, Sweden. hans.tygesen@telia.com
authors.forename: H
authors.initials: H
authors.lastname: Tygesen
authors.forename: C
authors.initials: C
authors.lastname: Wettervik
authors.forename: G
authors.initials: G
authors.lastname: Claes
authors.forename: C
authors.initials: C
authors.lastname: Drott
authors.forename: H
authors.initials: H
authors.lastname: Emanuelsson
authors.forename: J
authors.initials: J
authors.lastname: Solem
authors.forename: M
authors.initials: M
authors.lastname: Lomsky
authors.forename: G
authors.initials: G
authors.lastname: Rådberg
authors.forename: B
authors.initials: B
authors.lastname: Wennerblom
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D002940:Circadian Rhythm; D017023:Coronary Angiography; D015716:Electrocardiography, Ambulatory; D004724:Endoscopy; D005260:Female; D005728:Ganglia, Sympathetic / Q000503:physiopathology*; D015171:Ganglionectomy / Q000379:methods*; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D015635:Radionuclide Ventriculography; D012189:Retrospective Studies; D018667:Tilt-Table Test