title: Pathology and drug action in schizophrenia: insights from molecular biology.
abstract: Schizophrenia is a severe disorder of personality which has a genetic basis. Schizophrenia arises from a change in brain development. There is no strong evidence that disturbances in neurotransmitter systems are a primary cause. Anti-psychotic drugs act primarily through D2 and D3 dopamine receptors. The atypical drug clozapine may act through a number of different receptors, including D2, D3 and D4 dopamine receptors. Anti-psychotic drugs are inverse agonists at D2 dopamine receptors.
authors.affiliation: School of Animal and Microbial Sciences, University of Reading, Whiteknights, U.K.
authors.forename: P G
authors.initials: PG
authors.lastname: Strange
mesh_terms: D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D008040:Genetic Linkage; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology; D011954:Receptors, Dopamine / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D004298:Dopamine