title: Acute lymphocytic leukemia in a six-month-old western lowland gorilla (Gorilla gorilla gorilla).
abstract: A 6-mo-old hand-raised male western lowland gorilla (Gorilla gorilla gorilla) was diagnosed with acute lymphocytic leukemia based on complete blood count and bone marrow cytology. Clinical signs of the disease were pyrexia, abdominal distention, splenomegaly, and lethargy. Acute lymphocytic leukemia has rarely been reported in this species, and therapy was based on human oncologic protocols. Remission induction chemotherapy resulted in complete clearing of leukemia cells from the bone marrow. Consolidation and maintenance chemotherapy followed. Therapy was facilitated by the use of an infusion port for i.v. treatments and an indwelling lumbar catheter for intrathecal therapy. Side effects associated with chemotherapy were inappetence, moderate alopecia, pancytopenia resulting in sepsis, and bleeding tendency. In spite of initial success, the leukemia reappeared 120 days into treatment. The gorilla was euthanized 7 days later when respiratory distress developed. Intensive care by the animal staff was a key factor in the treatment of this gorilla.
authors.affiliation: Oklahoma City Zoological Park, Oklahoma 73111, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Barrie
authors.forename: K A
authors.initials: KA
authors.lastname: Backues
authors.forename: J
authors.initials: J
authors.lastname: Grunow
authors.forename: R
authors.initials: R
authors.lastname: Nitschke
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018420:Ape Diseases / Q000175:diagnosis / Q000188:drug therapy*; D001854:Bone Marrow Cells / Q000473:pathology; D005065:Euthanasia / Q000662:veterinary; D006071:Gorilla gorilla; D007621:Karyotyping / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D012008:Recurrence; D012074:Remission Induction; D013154:Spleen / Q000473:pathology