Pathogenic light chains and the B-cell repertoire.
Dysfunctional immunoglobulins (Igs) that are prone to aggregation are unavoidably generated by the diverse repertoire of B cells. Here, Fred Stevens and Yair Argon analyse the patterns of mutations that lead to pathological Igs, account for non-random mutations in human Ig sequences and suggest the exertion of selective forces, which contribute to determining and limiting the Ig repertoire.
Stevens
F J
FJ
Biosciences Division, Argonne National Laboratory, Argonne, IL, USA.
Argon
Y
Y
D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D009154:Mutation; D010265:Paraproteinemias / Q000235:genetics / Q000276:immunology; D017510:Protein Folding
D007147:Immunoglobulin Light Chains