Evidence for immunosuppression associated with Jembrana disease virus infection of cattle.
Jembrana disease virus (JDV) is a newly recognised bovine lentivirus causing an acute disease syndrome in Bali cattle (Bos javanicus) in Indonesia. We evaluated the effect of JDV infection on the antibody response to chicken ovalbumin (cOVA) and Brucella abortus Strain 19 in Bali cattle. In infected cattle the IgG and IgM response to cOVA was suppressed and delayed and the IgG response to B. abortus Strain 19 was delayed. The results indicate that the humoral immune response is suppressed and delayed in JDV infected cattle.
Wareing
S
S
Division of Veterinary and Biomedical Sciences, Murdoch University, WA, Australia. wareing@numbat.murdoch.edu.au
Hartaningsih
N
N
Wilcox
G E
GE
Penhale
W J
WJ
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D002004:Brucella Vaccine / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007108:Immune Tolerance; D016180:Lentivirus Infections / Q000276:immunology / Q000662:veterinary*; D017960:Lentiviruses, Bovine / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D011897:Random Allocation; D014611:Vaccination / Q000662:veterinary
D000914:Antibodies, Viral; D002004:Brucella Vaccine; D010047:Ovalbumin