title: The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.
abstract: Potent and selective thrombin inhibitors have been prepared with a piperazinedione template and L-amino acids. Likewise, incorporation of D-amino acids led to potent inhibitors with a novel mode of binding. Herein, the structure activity relationships and structural aspects of these compounds will be described.
authors.affiliation: Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Cody
authors.forename: C E
authors.initials: CE
authors.lastname: Augelli-Szafran
authors.forename: K A
authors.initials: KA
authors.lastname: Berryman
authors.forename: C
authors.initials: C
authors.lastname: Cai
authors.forename: A M
authors.initials: AM
authors.lastname: Doherty
authors.forename: J J
authors.initials: JJ
authors.lastname: Edmunds
authors.forename: J X
authors.initials: JX
authors.lastname: He
authors.forename: L S
authors.initials: LS
authors.lastname: Narasimhan
authors.forename: J
authors.initials: J
authors.lastname: Penvose-Yi
authors.forename: J S
authors.initials: JS
authors.lastname: Plummer
authors.forename: S T
authors.initials: ST
authors.lastname: Rapundalo
authors.forename: J R
authors.initials: JR
authors.lastname: Rubin
authors.forename: C A
authors.initials: CA
authors.lastname: Van Huis
authors.forename: L
authors.initials: L
authors.lastname: Leblond
authors.forename: P D
authors.initials: PD
authors.lastname: Winocour
authors.forename: M A
authors.initials: MA
authors.lastname: Siddiqui
mesh_terms: D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D015195:Drug Design; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000991:Antithrombins; D010879:Piperazines