Heterocyclic amine formation and the impact of structure on their mutagenicity.
The occurrence and formation of heterocyclic amines in foods is discussed in light of the consistent finding of a new class of imidazopyridines. In addition, a quantitative structure-activity relationship will be presented correlating the potency of these imidazopyridines to predicted chemical properties. Although no strong linear correlation is found between the potency and the chemical properties, a low dipole moment is found to be a qualitative predictor of high mutagenic potency.
Felton
J S
JS
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, University of California, Livermore 94551, USA. felton1@ilnl.gov
Knize
M G
MG
Hatch
F T
FT
Tanga
M J
MJ
Colvin
M E
ME
D007093:Imidazoles / Q000737:chemistry* / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity; D011725:Pyridines / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
D007093:Imidazoles; D009153:Mutagens; D011725:Pyridines