title: Vocal fold granuloma: successful treatment with botulinum toxin.
abstract: Vocal fold granulomas are benign but frequently recurrent lesions that can cause frustration for both the patient and the treating physician. Etiologic factors include endotracheal intubation, vocal abuse, and gastroesophageal reflux. Conventional treatment for granulomas has included medical, voice, and surgical therapy, none with uniform success. In this study 8 patients with vocal fold granulomas were treated with intralaryngeal injection of botulinum toxin. The resultant temporary paresis of the vocal folds allowed for a window of time during which the vocal process could heal and the granulomas could resolve without being exposed to ongoing intermittent contact and friction with the opposing arytenoid. Although the underlying cause of a granuloma must also be addressed, we have found that botulinum toxin can be a useful adjunct to traditional therapy and can lead to avoidance of repetitive surgical procedures.
authors.affiliation: University of California, San Diego, CA 92103-8891, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Orloff
authors.forename: S N
authors.initials: SN
authors.lastname: Goldman
mesh_terms: D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000008:administration & dosage*; D005260:Female; D006099:Granuloma / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014826:Vocal Cord Paralysis / Q000139:chemically induced; D014827:Vocal Cords / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D001905:Botulinum Toxins