Effects of long-term administration of testosterone enanthate on glucose metabolism in rhesus monkeys.
The effects of long term administration of testosterone enanthate (TE) on glucose metabolism including glucose tolerance test (GTT) and fasting serum insulin levels were evaluated in adult rhesus monkeys kept under controlled dietary conditions. Adult male rhesus monkeys (n = 9) were administered 50 mg of TE bimonthly for 32 months, whereas control animals were injected the vehicle only. Glucose concentration reached a maximum 5 min after an intravenous glucose load and thereafter decreased gradually to reach near baseline values within 60 min. Significant changes in GTT or t1/2 of glucose were not seen in animals treated with TE, throughout the treatment period. However, serum insulin levels decreased significantly from months 27-32 of TE treatment and returned to baseline values within 3 months of recovery.
Tyagi
A
A
Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India.
Rajalakshmi
M
M
Jeyaraj
D A
DA
Sharma
R S
RS
Bajaj
J S
JS
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004334:Drug Administration Schedule; D005215:Fasting; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D013739:Testosterone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone; C004648:testosterone enanthate