title: Experimental trypanosomiasis of natural hybrids between house mouse subspecies.
abstract: This study characterises the extent of the susceptibility to parasites (first demonstrated with helminths) of hybrids between Mus musculus domesticus and Mus musculus musculus. Experimental infections with Trypanosoma musculi of M. m. domesticus, M. m. musculus and their natural hybrids have been performed to compare their level of resistance/susceptibility. It appears that contrary to the results with helminths, hybrid mice present the same level of resistance/susceptibility to the trypanosome as M. m. musculus and M. m. domesticus individuals. This result is interpreted in the light of the modalities of host parasite interactions and leads us to hypothesise on the role of parasitism in the evolution of the house mouse hybrid zone.
authors.affiliation: Laboratoire Génome, Populations, Interactions, UPR 9060, Université Montpellier II, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Derothe
authors.forename: C
authors.initials: C
authors.lastname: Loubes
authors.forename: M
authors.initials: M
authors.lastname: Perriat-Sanguinet
authors.forename: A
authors.initials: A
authors.lastname: Orth
authors.forename: C
authors.initials: C
authors.lastname: Moulia
mesh_terms: D000818:Animals; D005260:Female; D020022:Genetic Predisposition to Disease; D006790:Host-Parasite Interactions; D006824:Hybridization, Genetic; D007113:Immunity, Innate; D008297:Male; D051379:Mice / Q000145:classification / Q000235:genetics*; D018512:Parasitemia / Q000469:parasitology; D012727:Sex Characteristics; D013045:Species Specificity; D014345:Trypanosoma / Q000502:physiology*; D014352:Trypanosomiasis / Q000276:immunology* / Q000469:parasitology