title: [Unusually high level of chromosome variability in cultured human peripheral blood lymphocytes].
abstract: A cytogenetic examination carried out in the inhabitants of Seversk (Tomsk oblast) and workers of the Siberian chemical industrial complex (a complex of nuclear-chemical and fuel plants), living in the same town, revealed unusually high level of spontaneous chromosomal variability both in control and industrial groups (total irradiation doses 1.8 to 3.7 and 9.3 to 15.7 Gy, respectively). The frequencies of cells with chromosomal aberrations (estimated per 100 cells) in control and industrial groups were 4.69, 6.04, and 6.64, respectively, and the total number of aberrations constituted 6.93, 8.47 and 12.06, respectively. These frequencies were several times higher compared to the summarized literature data on the control levels. The high average aberration level was caused by the elevated proportion of chromatid-type aberrations and paired fragments. The reasons for this are unclear. The levels of radioactive background and chemical air pollution in the town were not increased.
authors.affiliation: Research Center of Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Bochkov
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: L D
authors.initials: LD
authors.lastname: Katosova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Iakovleva
authors.forename: S A
authors.initials: SA
authors.lastname: Nazarenko
authors.forename: E O
authors.initials: EO
authors.lastname: Vasil'eva
authors.forename: V I
authors.initials: VI
authors.lastname: Platonova
authors.forename: A N
authors.initials: AN
authors.lastname: Chebotarev
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D014644:Genetic Variation; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D011830:Radiation Effects; D012426:Russia