Constructing immortalized human cell lines.
Obtaining an abundant supply of human cells with specific differentiated properties is a key issue in many research studies and biotechnology applications. Recent advances in this area include the finding that forced expression of the enzyme telomerase can greatly increase the proliferative potential of at least some types of human cells, and also the development of methods for culturing human stem cells.
Yeager
T R
TR
Children's Medical Research Institute 214 Hawkesbury Road, Westmead, Sydney, NSW 2145, Australia.
Reddel
R R
RR
D002460:Cell Line / Q000821:virology; D002461:Cell Line, Transformed; D004263:DNA Tumor Viruses / Q000235:genetics* / Q000472:pathogenicity; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008967:Molecular Biology / Q000379:methods; D027383:Papillomaviridae / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics; D013234:Stem Cells / Q000821:virology; D019098:Telomerase / Q000235:genetics
D019098:Telomerase