title: Local recurrence after curative excision of the rectum for cancer without adjuvant therapy: role of total anatomical dissection.
abstract: BACKGROUND
  The wide variability of reported local recurrence rates after curative resection of rectal cancer without adjuvant therapy may be a consequence of many different factors. However, few studies have investigated the potential effects of such factors on local recurrence by multivariate analysis. The present study examined clinical and tumour characteristics, operation type and operative technique as potential predictors of local recurrence in patients treated by surgery alone.
  
  
  METHODS
  Prospective data were analysed by bivariate and multivariate methods including actuarial survival and proportional hazards regression.
  
  
  RESULTS
  Local recurrence (pelvic or pelvic and systemic) was diagnosed in 59 of 596 patients. The 5-year actuarial local recurrence rate was 11.1 (95 per cent confidence interval 8.7-14.3) per cent. Independent predictive factors for local recurrence were: positive nodes (hazard ratio (HR) 5.5, P < 0.01); distal margin of 1 cm or less (HR 3.8, P < 0.01); venous invasion (HR 2.0, P = 0.02) and total anatomical dissection of the rectum (HR 2.0, P = 0.01). There was no difference in local recurrence between patients who had the mesorectum divided and those in whom it was totally excised.
  
  
  CONCLUSIONS
  Nodal involvement is the most potent predictor of local recurrence. In patients in whom total anatomical dissection is performed, total mesorectal excision confers no additional protection against local recurrence.
authors.affiliation: Department of Colon and Rectal Surgery, The University of Sydney at Concord Hospital, New South Wales, Australia.
authors.forename: E L
authors.initials: EL
authors.lastname: Bokey
authors.forename: B
authors.initials: B
authors.lastname: Ojerskog
authors.forename: P H
authors.initials: PH
authors.lastname: Chapuis
authors.forename: O F
authors.initials: OF
authors.lastname: Dent
authors.forename: R C
authors.initials: RC
authors.lastname: Newland
authors.forename: G
authors.initials: G
authors.lastname: Sinclair
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D004210:Dissection; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome