The medullary collecting duct urea transporters.
The terminal inner medullary collecting duct facilitated urea transporter, UT-A1, belongs to a family of four urea transporters. The inner medullary collecting duct also expresses three active urea transporters. Reducing urine concentrating ability in vivo upregulates UT-A1 and alters active urea secretion in the terminal inner medullary collecting duct, and induces active urea reabsorption in the initial inner medullary collecting duct.
Sands
J M
JM
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. jsands@emory.edu
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D007679:Kidney Medulla / Q000502:physiology*; D007685:Kidney Tubules, Collecting / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins; D009404:Nephrotic Syndrome / Q000503:physiopathology; D014508:Urea / Q000378:metabolism*; D014556:Urine / Q000502:physiology; D000096982:Urea Transporters
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D014508:Urea; D000096982:Urea Transporters