title: Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.
abstract: Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).
authors.affiliation: Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
authors.forename: N H
authors.initials: NH
authors.lastname: Lin
authors.forename: M A
authors.initials: MA
authors.lastname: Abreo
authors.forename: D E
authors.initials: DE
authors.lastname: Gunn
authors.forename: S A
authors.initials: SA
authors.lastname: Lebold
authors.forename: E L
authors.initials: EL
authors.lastname: Lee
authors.forename: J T
authors.initials: JT
authors.lastname: Wasicak
authors.forename: A M
authors.initials: AM
authors.lastname: Hettinger
authors.forename: J F
authors.initials: JF
authors.lastname: Daanen
authors.forename: D S
authors.initials: DS
authors.lastname: Garvey
authors.forename: J E
authors.initials: JE
authors.lastname: Campbell
authors.forename: J P
authors.initials: JP
authors.lastname: Sullivan
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: S P
authors.initials: SP
authors.lastname: Arneric
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D018679:Cholinergic Agonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D018679:Cholinergic Agonists; D004987:Ethers