title: Use of topical brimonidine to prevent intraocular pressure elevations following Nd:YAG-laser posterior capsulotomy.
abstract: OBJECTIVE
  To evaluate the efficacy of topical brimonidine tartrate 0.2% (Allergan, Irvine, CA) in the prophylactic treatment of acute intraocular pressure (IOP) rises following Nd:YAG laser posterior capsulotomy.
  
  
  METHODS
  This was a double-masked, randomized, placebo-controlled clinical study in 60 patients who underwent Nd:YAG laser posterior capsulotomy after extracapsular cataract extraction. Two doses of brimonidine or vehicle were administered before and after capsulotomy. Intraocular pressure was measured prior to commencing instillation and for 48 hours postoperatively.
  
  
  RESULTS
  Following posterior capsulotomy, the brimonidine group showed a significant mean percent reduction in IOP, while the vehicle group showed a significant mean percent increase in IOP. At 48 hours, mean IOP of both groups had returned to pre-laser level. There were no differences between the 2 groups in the incidence of clinical adverse experiences.
  
  
  CONCLUSIONS
  Two-dose brimonidine tartrate 0.2% effectively prevents acute IOP rises after Nd:YAG laser posterior capsulotomy.
authors.affiliation: Department of Ophthalmology, University of Patras Medical School, Greece.
authors.forename: S P
authors.initials: SP
authors.lastname: Gartaganis
authors.forename: E K
authors.initials: EK
authors.lastname: Mela
authors.forename: J M
authors.initials: JM
authors.lastname: Katsimpris
authors.forename: J K
authors.initials: JK
authors.lastname: Petropoulos
authors.forename: N K
authors.initials: NK
authors.lastname: Karamanos
authors.forename: J X
authors.initials: JX
authors.lastname: Koliopoulos
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000068438:Brimonidine Tartrate; D002387:Cataract Extraction; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy / Q000009:adverse effects*; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology / Q000517:prevention & control*; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000627:therapeutic use; D011810:Quinoxalines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011810:Quinoxalines; D000068438:Brimonidine Tartrate