title: CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis.
abstract: Interleukin-6 (IL-6) has recently been implicated in multiple sclerosis (MS), since IL-6 deficient mice were resistant to a demyelinating form of experimental autoimmune encephalomyelitis and IL-6 expression was upregulated in MS. The cytokine IL-6 and its action mediating soluble receptors (sIL-6R and sgp130) were measured in cerebrospinal fluid (CSF) and serum of 61 MS patients and 39 controls. In the presence of unchanged IL-6 concentrations, sIL-6R and sgp130 serum levels were significantly increased in MS and correlated with disease severity. Furthermore, sgp130 CSF levels were decreased in MS, suggesting a possibly altered IL-6 regulation in the CSF.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. padberg@nk-i.med.uni-muenchen.de
authors.forename: F
authors.initials: F
authors.lastname: Padberg
authors.forename: W
authors.initials: W
authors.lastname: Feneberg
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: M J
authors.initials: MJ
authors.lastname: Schwarz
authors.forename: D
authors.initials: D
authors.lastname: Körschenhausen
authors.forename: B D
authors.initials: BD
authors.lastname: Greenberg
authors.forename: T
authors.initials: T
authors.lastname: Nolde
authors.forename: N
authors.initials: N
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Trapmann
authors.forename: N
authors.initials: N
authors.lastname: König
authors.forename: H J
authors.initials: HJ
authors.lastname: Möller
authors.forename: H
authors.initials: H
authors.lastname: Hampel
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015703:Antigens, CD / Q000097:blood* / Q000134:cerebrospinal fluid*; D050822:Cytokine Receptor gp130; D004673:Encephalomyelitis, Acute Disseminated / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D019947:Receptors, Interleukin-6 / Q000097:blood; D012995:Solubility
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130