Development of an immunocontraceptive vaccine. Current status.
Development of an effective and modern contraceptive vaccine is a key factor in the global issue of regional population growth as well as agricultural, medical, economic and social development. A review was done of the current medical literature concerning development of an immunocontraceptive vaccine and relative molecular biology technology. Various approaches have been taken to identify candidate-specific antigens for immunocontraceptive development, such as sperm, zona pellucida and hormonal antigens. Suppressed fertility and the reversibility of these effects on mammalian species, including humans, have been demonstrated. The successful results obtained so far support the continued investigation for an effective immunocontraceptive vaccine.
Feng
H
H
Department of Urology, University of Iowa, Iowa City, USA. HuaiFeng@aol.com
Sandlow
J I
JI
Sparks
A E
AE
Sandra
A
A
D000818:Animals; D000941:Antigens / Q000276:immunology; D003269:Contraception, Immunologic; D005260:Female; D006728:Hormones / Q000276:immunology; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000276:immunology; D014612:Vaccines; D015044:Zona Pellucida / Q000276:immunology
D000941:Antigens; D006728:Hormones; D014612:Vaccines