Antibiotic susceptibility patterns and beta-lactamase production of animal and human isolates of Campylobacter in Lagos, Nigeria.
Forty-three stool samples and rectal swabs were collected from diarrhoeic and 20 non-diarrhoeic patients under 5 years of age at various general hospitals in Lagos. A total of 110 faecal samples from animals (101 from chickens and 9 from pigs) were obtained from Mitchel farm, Agege and Oshodi--Isolo Local Government farms at Ejigbo. Campylobacter species were isolated from 6 (13.9%) of 43 children with gastroenteritis and none from 20 asymptomatic subjects. Forty-nine (48.5%) isolates from the hundred and one faecal specimen were isolated from chicken, while 3 (33.33%) out of 9 were from pigs. Campylobacter jejuni was the most prevalent accounting for 79% of the total isolates and C. coli accounted for 25%. All the human strains were gentamicin sensitive, while streptomicin and cloxacillin were resistant. Erythromycin had a high activity (83.3%) on human strains and only 59.6% activity on animal strains. About ten percent (9.6%) of the strains produced beta-lactamase.
Smith
S I
SI
Genetics and Blood Disorders Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria. NIMR@home.metrong.com
Sansa
T I
TI
Coker
A O
AO
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects* / Q000201:enzymology; D002645:Chickens; D006801:Humans; D008826:Microbial Sensitivity Tests; D013552:Swine; D001618:beta-Lactamases / Q000096:biosynthesis*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases