Asymmetric synthesis of some substituted-3-phenyl prolines.
The asymmetric synthesis of carboxyphenyl prolines was performed according to Schöllkopf methodology, to prepare possible antagonists of the metabotropic glutamate receptor mGluR1.
Micheli
F
F
Glaxo Wellcome S.p.A., Medicines Research Centre, Verona, Italy. fm20244@glaxowellcome.co.uk
Di Fabio
R
R
Marchioro
C
C
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D018756:GABA Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*
D018756:GABA Antagonists; D018094:Receptors, Metabotropic Glutamate; D011392:Proline