Pre-Kaposi's sarcoma: an expansion of the spectrum of Kaposi's sarcoma lesions.
We report on a lymphoedematous form of classic Kaposi's sarcoma (KS) in which characteristic purplish lesions were surrounded by atypical oedematous, flesh-coloured papules. Histological examination of these papular lesions revealed a proliferation of grouped, rather thick-walled capillaries with inflammatory infiltrates. Hot-start PCR amplification with KS 330-233 primer sequences demonstrated the presence of human herpesvirus 8 (HHV-8) sequences. In addition, cells isolated from these oedematous papules showed morphological and immunohistochemical features similar to those reported for KS-derived spindle cells. As a whole, these results suggest that these oedematous papular lesions represent pre-KS lesions and may expand the clinico-pathological spectrum of KS. The role of oedema in their induction is discussed.
Simonart
T
T
Department of Dermatology, Erasme University Hospital, B-1070 Brussels, Belgium.
Dobbeleer
G D
GD
Peny
M
M
Fayt
I
I
Parent
D
D
Vooren
J
J
Noel
J
J
D000368:Aged; D001707:Biopsy, Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D006566:Herpesviridae Infections / Q000175:diagnosis / Q000473:pathology; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000473:pathology*; D012514:Sarcoma, Kaposi / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology