Paramunity-inducing effects of vaccinia strain MVA.
Vaccinia virus MVA is harmless for humans and animals both locally and parenterally. It offers paraspecific activities similar to those of comparable attenuated viruses of other pox genera, e.g. avipox or parapox. At the systemic level, MVA protects baby mice against lethal challenge with vesicular stomatitis virus (dose-response curve). MVA raises phagocytosis and NK-cell activity in humans and animals, whilst encouraging the induction of interferon alpha, interleukin-2 and -12 and colony-stimulating activity at the same time. The paramunity-inducing properties of MVA make it an ideal vector for the insertion of foreign genes. It is superior to other virus vectors because of its complex function. Inactivated MVA is also suitable as an inducer of paramunity.
Vilsmeier
B
B
Chair of Medical Microbiology, Infectious and Epidemic Diseases, Faculty of Veterinary Medicine, Ludwig-Maximilians-University of Munich.
D000818:Animals; D002460:Cell Line; D004285:Dogs; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007962:Leukocytes / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis; D018353:Rhabdoviridae Infections / Q000276:immunology*; D012899:Smallpox / Q000276:immunology* / Q000517:prevention & control; D012900:Smallpox Vaccine; D013601:T-Lymphocytes / Q000276:immunology*; D014616:Vaccinia virus / Q000276:immunology*; D014721:Vesicular stomatitis Indiana virus
D016898:Interferon-alpha; D007376:Interleukin-2; D012900:Smallpox Vaccine; D018664:Interleukin-12