title: Arterial pressure in humans during weightlessness induced by parabolic flights.
abstract: Results from our laboratory have indicated that, compared with those of the 1-G supine (Sup) position, left atrial diameter (LAD) and transmural central venous pressure increase in humans during weightlessness (0 G) induced by parabolic flights (R. Videbaek and P. Norsk. J. Appl. Physiol. 83: 1862-1866, 1997). Therefore, because cardiopulmonary low-pressure receptors are stimulated during 0 G, the hypothesis was tested that mean arterial pressure (MAP) in humans decreases during 0 G to values below those of the 1-G Sup condition. When the subjects were Sup, 0 G induced a decrease in MAP from 93 +/- 4 to 88 +/- 4 mmHg (P < 0.001), and LAD increased from 30 +/- 1 to 33 +/- 1 mm (P < 0.001). In the seated position, MAP also decreased from 93 +/- 6 to 87 +/- 5 mmHg (P < 0.01) and LAD increased from 28 +/- 1 to 32 +/- 1 mm (P < 0.001). During 1-G conditions with subjects in the horizontal left lateral position, LAD increased compared with that of Sup (P < 0.001) with no further effects of 0 G. In conclusion, MAP decreases during short-term weightlessness to below that of 1-G Sup simultaneously with an increase in LAD. Therefore, distension of the heart and associated central vessels during 0 G might induce the hypotensive effects through peripheral vasodilatation. Furthermore, the left lateral position in humans could constitute a simulation model of weightlessness.
authors.affiliation: Danish Aerospace Medical Centre of Research and Cardiovascular Laboratory, National University Hospital, DK-2200 Copenhagen, Denmark. damec@inet.uni2.dk
authors.forename: B
authors.initials: B
authors.lastname: Pump
authors.forename: R
authors.initials: R
authors.lastname: Videbaek
authors.forename: A
authors.initials: A
authors.lastname: Gabrielsen
authors.forename: P
authors.initials: P
authors.lastname: Norsk
mesh_terms: D000328:Adult; D016279:Atrial Function, Left / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D002496:Central Venous Pressure / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011311:Pressoreceptors / Q000502:physiology; D016683:Supine Position / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D014893:Weightlessness / Q000009:adverse effects*; D018474:Weightlessness Simulation / Q000379:methods*