Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases.
Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and beta-catenin and induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.
Kaibuchi
K
K
Division of Signal Transduction Nara Institute of Science and Technology 8916-5, Takayama, Ikoma, 630-0101, Japan. kaibuchi@bs. aist-nara.ac.jp.
Kuroda
S
S
Fukata
M
M
Nakagawa
M
M
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D003598:Cytoskeletal Proteins / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D004285:Dogs; D006801:Humans; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin; D020764:cdc42 GTP-Binding Protein / Q000502:physiology; D020830:rac1 GTP-Binding Protein / Q000502:physiology; D020703:ras GTPase-Activating Proteins; D020741:rho GTP-Binding Proteins / Q000502:physiology*
C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C101203:IQ motif containing GTPase activating protein 1; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin; D020703:ras GTPase-Activating Proteins; D020764:cdc42 GTP-Binding Protein; D020830:rac1 GTP-Binding Protein; D020741:rho GTP-Binding Proteins