Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a basic 38-amino acid regulatory peptide contained in the adrenal gland and involved in the control of its secretory activity. Bilateral splanchnic-nerve section caused in the rat a significant decrease in PACAP38 adrenal content and concentration, as measured by RIA. In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function.
Ginda
W J
WJ
Department of Histology and Embryology, School of Medicine, Poznan, Poland.
Nussdorfer
G G
GG
Malendowicz
L K
LK
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D003714:Denervation; D005260:Female; D009479:Neuropeptides / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017208:Rats, Wistar; D013153:Splanchnic Nerves / Q000502:physiology / Q000601:surgery*; D013563:Sympathectomy, Chemical
C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016627:Oxidopamine