title: Hepatocellular carcinoma with metastasis to the rib complicated by hemothorax. An autopsy case.
abstract: A 64-year old man was admitted to our hospital with multiple hepatocellular carcinoma (HCC) lesions in the liver, lung and bone. Three weeks after admission, the patient became complicated with right upper chest pain. A chest radiograph showed a marked increase in right pleural effusion. Thoracentesis demonstrated a hemothorax. Despite treatment with a continuous pleural tap and blood transfusions, the patient's clinical status worsened and he developed severe dyspnea. His right pleural effusion might be considered to be caused by a rupture of the HCC metastasis in the right 2nd rib. The patient died due to respiratory and hepatic failure 26 hours after his occurring the pleural effusion. An autopsy revealed moderately differentiated HCC in the liver, lung and bone. The HCC metastasis of the right 2nd rib was found to have torn the nearby pleura. We described a rare case in which hemothorax was caused by a ruptured rib-based HCC.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: M
authors.initials: M
authors.lastname: Hashiguchi
authors.forename: K
authors.initials: K
authors.lastname: Azuma
authors.forename: J
authors.initials: J
authors.lastname: Shimono
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000556:secondary*; D006491:Hemothorax / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012272:Ribs