Chiroptical rhythmicity, Part 1: Description of a novel phenomenon.
A novel chiroptical phenomenon named "chiroptical rhythmicity" is described. Chiroptical rhythmicity consists of multiple reversible circular dichroism Cotton effect sign inversions that follow a rhythmical pattern with respect to the continuous addition of a ligand (L-His) to the sample (a septi(p-phenylene)-based receptor bound to phosphatidylcholine bilayers). Decrease and blue-shift of the 1La absorption of the oligophenylene chromophore indicated that partial "H" aggregation occurs during chiroptical rhythmicity. Based on stereochemical considerations for monomeric and tetrameric oligophenylenes, a hypothetical mechanism is discussed.
Ghebremariam
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Department of Chemistry, Georgetown University, Washington, DC 20057, USA.
Matile
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D002942:Circular Dichroism; D008024:Ligands; D008051:Lipid Bilayers / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010713:Phosphatidylcholines / Q000737:chemistry; D011955:Receptors, Drug / Q000737:chemistry; D013237:Stereoisomerism
D008024:Ligands; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D011955:Receptors, Drug