Understanding CNS remyelination: clues from developmental and regeneration biology.
A guiding principle in remyelination research has been to seek clues to its nature in developmental studies on myelination. This "recapitulation hypothesis" argues that the regenerative response involves rerunning much the same programme as occurs during the developmental process. Here we examine the extent to which current evidence supports this hypothesis and whether this is a useful conceptual framework within which to study remyelination and suggest that an equally fruitful approach is to look to regenerative processes in other tissues.
Franklin
R J
RJ
Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. rjf1000@cam.ac.uk
Hinks
G L
GL
D000818:Animals; D001369:Axons / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D009186:Myelin Sheath / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology; D013234:Stem Cells / Q000502:physiology
D006133:Growth Substances