title: The prevalence of Chlamydia pneumoniae antibodies in Thai patients with coronary artery disease.
abstract: Blood samples were obtained from 243 consecutive coronary artery disease (CAD) patients (177 male, 66 female) aged 35-78 years (mean, 61 years) admitted for coronary angiography because of suspected coronary heart disease, and from 115 blood donors (91 male, 24 female) aged 25-60 years (mean, 47 years). Of the 243 CAD patients, 179 (74%) were positive by an ELISA method for Chlamydia pneumoniae antibodies IgG and 132 (54%) were positive for C. pneumoniae IgA. Among the 115 blood donors, 80 (70%) were positive for C. pneumoniae IgG and 49 (43%) were positive for C. pneumoniae IgA. When IgG antibodies were considered, there was no significant difference between CAD patients and healthy controls (OR = 1.29, 95% CI = 0.79-2.10, p > 0.05). In cases of positive IgA antibodies alone, there was a significant difference between CAD patients and healthy controls (OR = 1.58, 95% CI = 1.01-2.4, p = 0.029). If both IgG and IgA antibodies were positive, OR was increased from 1.58 to 1.80 (95% CI = 0.97-3.36, p = 0.044). In conclusion, C. pneumoniae infection is common in Thai people but chronic C. pneumoniae infection is more common in CAD patients than in middle-aged blood donors.
authors.affiliation: Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Leowattana
authors.forename: N
authors.initials: N
authors.lastname: Mahanonda
authors.forename: K
authors.initials: K
authors.lastname: Bhuripunyo
authors.forename: A
authors.initials: A
authors.lastname: Leelarasamee
authors.forename: S
authors.initials: S
authors.lastname: Pokum
authors.forename: B
authors.initials: B
authors.lastname: Suwimol
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D015897:Comorbidity; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D013785:Thailand / Q000453:epidemiology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G