title: Prediction of improvement of cerebral perfusion with I-123 iomazenil SPECT.
abstract: We report a case of 61-year old man who was suffering from cerebrovascular disease with right hemiparesis and received I-123 iomazenil (IMZ) SPECT prior to carotid endoarterectomy. Severe stenosis of the right internal carotid artery and occlusion of the left middle cerebral artery (MCA) were revealed by cerebral angiography, and a hypoperfused area in left MCA territory and crossed cerebellar diaschisis (CCD) on I-123 IMP SPECT was demonstrated. In contrast, IMZ SPECT showed symmetric normal distribution. After the carotid endoarterectomy, the hypoperfused area in left MCA territory on IMP SPECT and hemiparesis had improved. It is thought that IMZ SPECT can be a useful tool for the prediction of improvement of cerebral perfusion and the clinical outcome.
authors.affiliation: Department of Radiology, Fukui Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsuchida
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekura
authors.forename: N
authors.initials: N
authors.lastname: Sadato
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ishii
mesh_terms: D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D001921:Brain / Q000000981:diagnostic imaging*; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000601:surgery; D002539:Cerebral Arterial Diseases / Q000000981:diagnostic imaging* / Q000601:surgery; D002544:Cerebral Infarction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000601:surgery; D002560:Cerebrovascular Circulation; D016894:Endarterectomy, Carotid; D005260:Female; D005442:Flumazenil / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007839:Functional Laterality; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000209:etiology; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D005442:Flumazenil; C063038:iomazenil