Antioxidant protection against iron toxicity: plasma changes during cardiopulmonary bypass in neonates, infants, and children.
Cardiopulmonary bypass surgery is associated with the release of low molecular mass iron, which increases the saturation of plasma transferrin to over 50% in all adult patients treated. In a significant minority, however plasma transferrin becomes 100% iron saturated and non-transferrin bound iron can be detected in the plasma. An iron-saturated transferrin is also a common physiological finding in normal term and pre-term infants at a time when their plasma antioxidants, which protect against iron toxicity and radical scavenging, are profoundly different from those seen in adults. This study was conducted to assess the extent to which antioxidants, which protect against iron toxicity, are altered in neonates, infants, and children undergoing cardiopulmonary bypass surgery.
Mumby
S
S
Directorate of Anaesthesia and Critical Care, Royal Brompton and Harefield NHS Trust, and The National Heart and Lung Institute, London, UK.
Chaturvedi
R
R
Brierley
J
J
Lincoln
C
C
Petros
A
A
Redington
A
A
Gutteridge
J M
JM
D000975:Antioxidants / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D002570:Ceruloplasmin / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D016166:Free Radical Scavengers; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007501:Iron / Q000009:adverse effects* / Q000097:blood*; D008297:Male; D012016:Reference Values; D013438:Sulfhydryl Compounds / Q000097:blood; D014168:Transferrin / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D013438:Sulfhydryl Compounds; D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin