title: Rapid loss of dorsal horn lectin binding after massive brachial plexus axotomy in young rats.
abstract: Lectins are proteins with binding affinities for specific sugars in complex glycoconjugates, some of which have been implicated in limiting synaptic plasticity or modulating nerve growth and guidance. We studied the expression of the glycoconjugate recognized by the isolectin B4 of Griffonia simplicifolia (Gs-IB4) in spinal dorsal horns after massive axotomy of the brachial plexus in weanling rats. Gs-IB4+ binding sites in Rexed's lamina II were rapidly reduced after massive peripheral axotomy. This rapid loss suggests that multiple nerve lesions minimize the number of intact fibers that converge with lesioned fibers into the same cord segments and thus may prevent the plastic changes accompanying the lesion of single nerves.
authors.affiliation: Instituto de Biofisica C. Chagas Filho, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Sant'Anna-da-Costa
authors.forename: S L
authors.initials: SL
authors.lastname: Carvalho
authors.forename: R
authors.initials: R
authors.lastname: Mendez-Otero
authors.forename: L A
authors.initials: LA
authors.lastname: Cavalcante
mesh_terms: D000818:Animals; D019771:Axotomy; D001917:Brachial Plexus / Q000601:surgery*; D005260:Female; D005727:Ganglia, Spinal / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013126:Spinal Nerve Roots / Q000378:metabolism
chemical_list: D037102:Lectins