title: Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles.
abstract: Two series of oxazolidinone derivatives having substituted isoxazoles were synthesized and tested for antibacterial activities against several Gram-positive strains including the resistant strains of Staphylococcus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed in vitro activities (MIC) comparable or superior to the reference compound vancomycin.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
authors.forename: A N
authors.initials: AN
authors.lastname: Pae
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Joo
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: K I
authors.initials: KI
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: H Y
authors.initials: HY
authors.lastname: Koh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007555:Isoxazoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D007555:Isoxazoles; D010080:Oxazoles