Toxic shock syndrome toxin-1 (TSST-1) antibody levels in burned children.
Young children with burns are at risk of developing a toxic shock-like illness during the first 2-3 days after the injury. The staphylococcal exotoxin, toxic-shock syndrome toxin-1 (TSST-1) is implicated in development of this illness. Low levels or absence of anti-TSST-1 antibodies may indicate susceptibility to this illness. Anti-TSST-1 antibody levels were measured in consecutive cases admitted to the children's burns unit. Results of antibody levels in 38 of the youngest children, aged 0.04-4.0 years are reported. At the time of admission to the unit 50% of the children had IgG antibodies to TSST-1. A higher number of young burned children had antibodies to TSST-1 than expected.
Childs
C
C
MRC Trauma Group, Regional Paediatric Burns Unit, Booth Hall Children's Hospital, Manchester, UK. cchilds@man.ac.uk
Edwards Jones
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V
Dawson
M
M
Davenport
P J
PJ
D001427:Bacterial Toxins; D015415:Biomarkers; D002056:Burns / Q000150:complications / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D004768:Enterotoxins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D007231:Infant, Newborn; D012772:Shock, Septic / Q000276:immunology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens
D001427:Bacterial Toxins; D015415:Biomarkers; D004768:Enterotoxins; D007074:Immunoglobulin G; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal