title: Are glomerular filtration rate estimations necessary before high dose methotrexate?
abstract: Glomerular filtration rates (GFR) were estimated in 168 children (227 estimates) before treatment for haematological malignancies with high dose, intravenous methotrexate. Clinical management was altered on the basis of GFR in only two cases, both of whom had tumour lysis syndrome. Routine estimations of GFR do not contribute to management.
authors.affiliation: Department of Haematology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children, London WC1N 3JH, UK.
authors.forename: H
authors.initials: H
authors.lastname: Rees
authors.forename: I M
authors.initials: IM
authors.lastname: Hann
authors.forename: J M
authors.initials: JM
authors.lastname: Chessells
authors.forename: D K
authors.initials: DK
authors.lastname: Webb
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003362:Cost-Benefit Analysis; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects* / Q000502:physiology; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate