The power of evolution: accessing the synthetic potential of P450s.
Cytochromes P450 can catalyse hydroxylation reactions that are of considerable potential synthetic value, but a number of practical difficulties have hitherto prevented their use for this purpose. Recent advances, including intelligently designed laboratory evolution experiments, promise to overcome these obstacles, and to add P450s to the enzymatic armoury of the chemist.
Roberts
G C
GC
Centre for Mechanisms of Human Toxicity, Hodgkin Building, University of Leicester, PO Box 138, Lancaster Road, Leicester, LE1 9HN, UK. gcr@le.ac.uk
D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000235:genetics; D019020:Directed Molecular Evolution; D006801:Humans; D006900:Hydroxylation
D003577:Cytochrome P-450 Enzyme System