T cell malignant lymphoma in the central nervous system after acute lymphoblastic leukemia in a child.
A malignant lymphoma developed in the central nervous system (CNS) of a 7-year-old boy 5 years after he had received chemotherapy and cranial irradiation for acute lymphoblastic leukemia (ALL). Bone marrow analysis of the original leukemia showed a pre-B cell phenotype, whereas the resected brain tumor showed a T cell phenotype on immunophenotypic analysis. Because of this difference in immunophenotype, and because the patient had received multiple-drug chemotherapy and 1,800 cGy of cranial irradiation for the original ALL, we consider that the malignant lymphoma was a second neoplasm. This is a very rare case in two respects: it was a malignant lymphoma arising in the CNS as a second neoplasm after ALL and a T cell lymphoma occurring in a child.
Uetsuka
S
S
Department of Neurosurgery, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505 Japan.
Kajiwara
K
K
Suehiro
E
E
Nishizaki
T
T
Ito
H
H
Kawasaki
K
K
D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology; D002675:Child, Preschool; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000209:etiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*