title: [Hypolipidemic action of ascofuranone in hepatoblastoma G2 cell culture].
abstract: Ascofuranone, an isoprenoid antibiotic, suppressed 14C acetate incorporation into cholesterol, cholesterol ethers, triglycerides, phospholipids and free fatty acids in Hep G2 cell culture. Such a complex action of the antibiotic on lipid synthesis and metabolism was not connected with the inhibition of protein synthesis and the antibiotic toxicity.
authors.affiliation: Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow.
authors.forename: A S
authors.initials: AS
authors.lastname: Trenin
mesh_terms: D002788:Cholesterol Esters / Q000096:biosynthesis; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis; D018197:Hepatoblastoma / Q000378:metabolism* / Q000473:pathology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D010743:Phospholipids / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000494:pharmacology*; D014280:Triglycerides / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
chemical_list: D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D010743:Phospholipids; D012717:Sesquiterpenes; D014280:Triglycerides; C006640:ascofuranone