title: Bone scintigraphy and magnetic resonance imaging in adult-onset Still's disease.
abstract: Adult-onset Still's disease (AOSD) is an acute systemic inflammatory disorder of unknown origin. We report a patient whose AOSD presented with the commonly accepted diagnostic clinical signs and laboratory parameters. The painful joints distinctly demonstrated increased uptake of 99mTc-methylene diphosphonate in scintigraphy and areas of increased gadolinium-enhanced signal in MRI. Biopsies indicated bone marrow edema. AOSD in association with bone marrow edema had not been previously demonstrated. AOSD is often diagnosed after a considerable delay, bone scintigraphy, and magnetic resonance imaging may offer new imaging techniques for early diagnosis and successful therapy in follow-up examinations.
authors.affiliation: Department of Internal Medicine, Karl-Franzens University, Graz, Austria.
authors.forename: W J
authors.initials: WJ
authors.lastname: Schnedl
authors.forename: R W
authors.initials: RW
authors.lastname: Lipp
authors.forename: M
authors.initials: M
authors.lastname: Trinker
authors.forename: G
authors.initials: G
authors.lastname: Ranner
authors.forename: F
authors.initials: F
authors.lastname: Schreiber
authors.forename: G J
authors.initials: GJ
authors.lastname: Krejs
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D010146:Pain; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate