Effects of bifemelane on incomplete cerebral ischaemia-induced reduction of long-term potentiation in rat hippocampal neurones in vivo.
In the present study, we investigated the effects of bifemelane on the reduction of hippocampal long-term potentiation after transient ischaemia. Bilateral common carotid arteries were clamped for 10 min. in halothane-anaesthetized rats. Thirty min. before occlusion, bifemelane (25 mg/kg, intraperitoneally) or saline was administered to the rats. Four days after occlusion, we measured long-term potentiation in Schaffer collateral-CA1 synapses and perforant path-dentate gyrus synapses in vivo. Long-term potentiation was significantly reduced in both the Schaffer collateral-CA1 and perforant path-dentate gyrus synapses in the saline-injected group. However bifemelane decreased the ischaemia-induced reduction of long-term potentiation in perforant path-dentate gyrus synapses, but not in Schaffer collateral-CA1 synapses. The findings suggest that bifemelane deserves further attention with regard to possible protective role in ischaemia.
Mori
K
K
Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan. kimori@med.hokudai.ac.jp
Suda
N
N
Togashi
H
H
Matsumoto
M
M
Saito
H
H
Yoshioka
M
M
D000818:Animals; D019540:Area Under Curve; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D002339:Carotid Arteries / Q000473:pathology; D004566:Electrodes; D004594:Electrophysiology; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D018697:Nootropic Agents / Q000494:pharmacology*; D019580:Perforant Pathway / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects
D001559:Benzhydryl Compounds; D018697:Nootropic Agents; C031906:bifemelane