title: [Atrial fibrillation--new knowledge yields new therapeutic possibilities].
abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia prompting treatment. Advances in our knowledge of the pathophysiology of AF provide the basis for new and improved treatment modalities. Thus, focal excitation and localised impulse conduction defects are possible trigger factors which can be counteracted by focal ablation and pacing synchronisation, respectively. Perpetuation of AF, caused by continuous multisite re-entry, is promoted by successive shortening of repolarisation. Internal defibrillation and anatomical limitation of re-entry are treatments that counteract perpetuation of the arrhythmia. Current knowledge of AF and the application of new treatments are discussed by the Lund AF research group.
authors.affiliation: Avdelningen för kardiologi, S:t Petersburg, Ryssland. bertil.olsson@kard.lu.se
authors.forename: S B
authors.initials: SB
authors.lastname: Olsson
authors.forename: J
authors.initials: J
authors.lastname: Carlson
authors.forename: T
authors.initials: T
authors.lastname: Fåhraeus
authors.forename: A
authors.initials: A
authors.lastname: Hansson
authors.forename: E
authors.initials: E
authors.lastname: Hertervig
authors.forename: M
authors.initials: M
authors.lastname: Ingemansson
authors.forename: O
authors.initials: O
authors.lastname: Kongstad
authors.forename: C J
authors.initials: CJ
authors.lastname: Lindholm
authors.forename: C
authors.initials: C
authors.lastname: Meurling
authors.forename: P
authors.initials: P
authors.lastname: Platonov
authors.forename: A
authors.initials: A
authors.lastname: Roijer
authors.forename: S
authors.initials: S
authors.lastname: Yuan
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D004562:Electrocardiography; D006801:Humans