title: Primary malignant melanoma of the uterine cervix: case report and review of the literature.
abstract: This is a case report and review of the literature on primary melanoma of the cervix. There have been only 26 published cases of primary cervical melanoma and most are poorly documented and doubtful. The patients' ages ranged from 26 to 78 years old with a mean age of 55 +/- 13 years. The main presenting symptom was vaginal bleeding (83.0%). The majority of the patients, 88%, presented in stage I or II. Treatment varied from a simple excision of a cervical mass to a radical hysterectomy with lymph node dissection and adjuvant radiation or chemotherapy. Our patient presented with vaginal bleeding and was diagnosed as having stage IIa cervical melanoma. She underwent a radical hysterectomy, partial vaginectomy, and pelvic and paraaortic lymph node dissection. She received adjuvant radiation therapy and her survival was 29 months. The prognosis of primary cervical melanoma is usually poor and unpredictable. We recommend a radical hysterectomy and vaginectomy, if necessary, to obtain negative surgical margins of at least 2 cm. We advocate lymphadenectomy only for grossly positive nodes.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami-School of Medicine, Miami, Florida, 33136, USA.
authors.forename: G
authors.initials: G
authors.lastname: Cantuaria
authors.forename: R
authors.initials: R
authors.lastname: Angioli
authors.forename: J
authors.initials: J
authors.lastname: Nahmias
authors.forename: R
authors.initials: R
authors.lastname: Estape
authors.forename: M
authors.initials: M
authors.lastname: Penalver
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008545:Melanoma / Q000628:therapy*; D014594:Uterine Neoplasms / Q000628:therapy*