Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.
The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.
Persons
D A
DA
Department of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Paulson
R F
RF
Loyd
M R
MR
Herley
M T
MT
Bodner
S M
SM
Bernstein
A
A
Correll
P H
PH
Ney
P A
PA
D016475:3T3 Cells; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D020451:Contig Mapping; D005622:Friend murine leukemia virus; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009115:Muridae; D020033:Protein Isoforms / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D012192:Retroviridae Infections / Q000235:genetics; D013045:Species Specificity; D013154:Spleen / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D014412:Tumor Virus Infections / Q000235:genetics
D020033:Protein Isoforms; D011956:Receptors, Cell Surface; C080835:RON protein; D020794:Receptor Protein-Tyrosine Kinases