title: Evaluation of postural stability in workers exposed to lead at a secondary lead smelter.
abstract: Postural sway testing was carried out on a group of 145 workers exposed to lead in a secondary lead smelter and 84 workers not exposed to lead in a hinge manufacturing plant. All workers were measured for blood lead levels (BLL) and erythrocyte zinc protoporphyrin (ZPP) concentrations at the time of testing and both a total cumulative and a time-weighted average BLL value was constructed for the lead exposed workers. The lead exposed workers mean BLL at the time of testing was 38.9 microg/dl and the non-exposed workers mean was 2.3 microg/dl. ZPP levels averaged 55.2 microg/dl for exposed workers and 18.9 microg/dl for non-exposed workers. Total cumulative BLL averaged 83476 microg/dl days for the exposed workers, with a mean time-weighted average BLL of 35.1 microg/dl. Six tests of postural stability, four two leg conditions and two single leg conditions were administered to all subjects using a force platform to produce measurements of sway for comparison purposes. The two leg conditions also manipulated the visual and proprioceptive systems. A statistically significant association was observed for sway measurements and the current BLL for all workers, but not with the current BLL of only the lead exposed workers. No statistically significant associations were present with the cumulative measures of long-term exposure. Of the six tests of sway, only the single leg conditions showed significant exposure effects. The results suggest effects of lead exposure among those with average BLL near 40.0 microg/dl, but only in the most challenging one leg conditions.
authors.affiliation: U.S. Department of Health and Human Services, Public Health Service/Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Sciences, Cincinnati, Ohio 45226, USA. RBDI@CDC.GO
authors.forename: R B
authors.initials: RB
authors.lastname: Dick
authors.forename: L E
authors.initials: LE
authors.lastname: Pinkerton
authors.forename: E F
authors.initials: EF
authors.lastname: Krieg
authors.forename: R E
authors.initials: RE
authors.lastname: Biagini
authors.forename: J A
authors.initials: JA
authors.lastname: Deddens
authors.forename: W S
authors.initials: WS
authors.lastname: Brightwell
authors.forename: P L
authors.initials: PL
authors.lastname: Grubb
authors.forename: B T
authors.initials: BT
authors.lastname: Taylor
authors.forename: J M
authors.initials: JM
authors.lastname: Russo
mesh_terms: D004791:Enzyme Inhibitors / Q000097:blood; D004912:Erythrocytes / Q000737:chemistry; D006801:Humans; D007854:Lead / Q000097:blood* / Q000633:toxicity*; D016273:Occupational Exposure / Q000009:adverse effects*; D004856:Postural Balance / Q000187:drug effects*; D011524:Protoporphyrins / Q000097:blood*; D011597:Psychomotor Performance / Q000187:drug effects; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead