Effects of aspirin (acetylsalicylic acid) and Cataflam (potassium diclofenac) on some biochemical parameters in rats.
The effects of graded doses of aspirin (acetylsalicylic acid) and cataflam (potassium diclofenac) on serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, 5'Nucleotidase, methaemoglobin, total and conjaged bilirubin were investigated in wistar rats. Results showed a significant increase (P < 0.05) in the levels of alanine animotransferase, aspartate amino transferase, methaemoglobin, total and conjugated bilirubin upon treatment of animals with both drugs. Aspirin significantly decreased (P < 0.05, P < 0.00) the activity of alkaline phsophatase but increased the activity of 5'ucleotidase while cataflam significantly increased the activity of alkaline phosphatase (P < 0.001) and 5'nucletodase (P < 0.05). These effects were however dose dependent and the biochemical implications of these results are discussed.
Ebong
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PE
Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.
Eyong
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Udosen
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D000410:Alanine Transaminase / Q000097:blood* / Q000187:drug effects; D000469:Alkaline Phosphatase / Q000097:blood* / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood* / Q000187:drug effects; D001241:Aspirin / Q000009:adverse effects*; D001663:Bilirubin / Q000097:blood*; D001835:Body Weight; D004008:Diclofenac / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008111:Liver Function Tests; D008708:Methemoglobinemia / Q000097:blood* / Q000139:chemically induced; D009708:Nucleotidases / Q000097:blood* / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; C030287:nucleotidase; D001241:Aspirin; D001663:Bilirubin