Ultrastructural localization of Sm15 and Sm25, two major tegumental adult worm antigens of Schistosoma mansoni.
Sm15 and Sm25 are two of the principal tegumental antigens recognized by antibodies from mice protectively vaccinated with adult worm tegumental membranes and may therefore be potential vaccine candidate antigens. Using antibodies affinity purified from anti-tegumental membrane anti-sera, and antibodies raised against the recombinant antigens, Sm15 and Sm25 were shown to be located specifically in the tegument of adult worms being distributed throughout the syncitium but not associated with the outer membrane.
Abath
F G
FG
Instituto Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Brazil. fabath@gene.dbbm.fiocruz.br
Hirst
E M
EM
Hagan
P
P
Simpson
A J
AJ
D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis*; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000032:analysis*; D051379:Mice; D016253:Microscopy, Immunoelectron; D012550:Schistosoma mansoni / Q000737:chemistry / Q000276:immunology / Q000648:ultrastructure*
D000947:Antigens, Helminth; D008562:Membrane Glycoproteins; C068960:Sm25 antigen, Schistosoma mansoni