Mild trimethylaminuria caused by common variants in FMO3 gene.
Mild to transient trimethylaminuria is caused by common variants in the FMO3 gene leading to greatly reduced enzyme activity in vivo. FMO3 deficiency may have clinical relevance well beyond unpleasant body odour.
Zschocke
J
J
Kohlmueller
D
D
Quak
E
E
Meissner
T
T
Hoffmann
G F
GF
Mayatepek
E
E
D000328:Adult; D002648:Child; D005808:Genes, Recessive; D014644:Genetic Variation; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000652:urine*; D008744:Methylamines / Q000652:urine*; D020125:Mutation, Missense; D010105:Oxygenases / Q000172:deficiency / Q000235:genetics*; D013577:Syndrome
D008744:Methylamines; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); C023336:trimethylamine