title: Activated protein C resistance: a study among 60 thromboembolic patients in the Singapore population.
abstract: Resistance to activated protein C (APC-R) is the commonest inherited cause of thrombosis among Caucasians. Few studies have been carried out on its prevalence in Asians. We conducted a prospective study on 60 patients with thromboembolism to determine its prevalence in our local population. The Factor V Leiden (VaQ506) mutation associated with this condition was detected by amplification of the Factor V gene by polymerase chain reaction (PCR) and digestion of the fragment with Mnl I. Three patients were found to be heterozygous for this mutation. None of the 3 patients had other concomitant hypercoagulable states. In addition, we studied the prevalence of this condition in Malays which was found to be 0.5%. Our study suggests that the incidence of APC-R is much lower here compared to the West.
authors.affiliation: Department of Haematology, Singapore General Hospital, Singapore.
authors.forename: L C
authors.initials: LC
authors.lastname: Lim
authors.forename: H H
authors.initials: HH
authors.lastname: Tan
authors.forename: L H
authors.initials: LH
authors.lastname: Lee
authors.forename: S L
authors.initials: SL
authors.lastname: Tien
authors.forename: A
authors.initials: A
authors.lastname: Abdul Ghafar
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002681:China / Q000208:ethnology; D015331:Cohort Studies; D015252:Deoxyribonucleases, Type II Site-Specific; D005165:Factor V / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D007194:India / Q000208:ethnology; D008296:Malaysia / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011446:Prospective Studies; D012846:Singapore; D013923:Thromboembolism / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C095381:factor V Leiden; D005165:Factor V; C052155:endodeoxyribonuclease MnlI; D015252:Deoxyribonucleases, Type II Site-Specific