Bidirectional signals establish boundaries.
Recent studies have shown that the formation of boundaries between the segments - rhombomeres - of the vertebrate hindbrain depends on bidirectional signalling between neighbouring cells. This signalling is mediated by Eph receptors and their ligands, which has been found to restrict cell intermingling in vitro.
Klein
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European Molecular Biology Laboratory Meyerhofstrasse 1, 69117, Heidelberg, Germany. klein@embl-heidelberg.de
D000818:Animals; D002450:Cell Communication; D004625:Embryo, Nonmammalian / Q000378:metabolism / Q000648:ultrastructure; D017629:Gap Junctions / Q000502:physiology; D008024:Ligands; D008565:Membrane Proteins / Q000502:physiology*; D009024:Morphogenesis; D009419:Nerve Tissue Proteins / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D012249:Rhombencephalon / Q000196:embryology / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology
D008024:Ligands; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D020794:Receptor Protein-Tyrosine Kinases