The ethylene-response pathway: signal perception to gene regulation.
Tremendous strides have been made in the past year toward elucidating the ethylene-response pathway. Ethylene is perceived by a family of histidine kinase-like receptors, which negatively regulate ethylene responses. Binding of ethylene requires a copper cofactor, and proper receptor function relies on a copper transporter. Downstream, EIN2 is a structurally novel protein containing an integral membrane domain. In the nucleus, the EIN3 family of DNA-binding proteins regulates transcription in response to ethylene, and an immediate target of EIN3 is a DNA-binding protein of the AP2/EREBP family.
Chang
C
C
Department of Cell Biology and Molecular Genetics, Maryland Agricultural Experiment Station, HJ Patterson Hall, University of Maryland, College Park, MD 20742, USA. cc203@umail.umd.edu
Shockey
J A
JA
D017360:Arabidopsis / Q000235:genetics / Q000502:physiology*; D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D005030:Ethylenes / Q000378:metabolism / Q000494:pharmacology*; D018506:Gene Expression Regulation, Plant; D000071677:Histidine Kinase; D009687:Nuclear Proteins / Q000502:physiology; D010940:Plant Proteins / Q000502:physiology*; D011494:Protein Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors
D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; C119963:EIN2 protein, Arabidopsis; C106987:EIN3 protein, Arabidopsis; D005030:Ethylenes; D009687:Nuclear Proteins; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D014157:Transcription Factors; C083750:ethylene receptors, plant; C036216:ethylene; D011494:Protein Kinases; D000071677:Histidine Kinase