title: [Artificial amniotic fluid instillation in premature rupture of fetal membranes and extreme prematurity as alternative therapy].
abstract: We report two cases of premature rupture of membranes and oligohydramnios (gestational age: 23rd/24th week). In both pregnancies artificial instillation of amniotic fluid (AIF) was performed once a week. We hypothesize that fetal head compression with impaired cerebral perfusion due to oligohydramnios causes periventricular leukomalacia. Prolongation of gestation of 36/23 days without neurological lesion support this method. Surveillance of these pregnancies in a perinatal center has to include very early detection of chorioamnionitis. If not so, gained prolongation of pregnancy with a lower rate of cerebral damage becomes harmful due to infection. Clinical benefits and disadvantages of this technique have to be evaluated in a prospective randomized trial.
authors.affiliation: Universitätsfrauenklinik Leipzig.
authors.forename: R
authors.initials: R
authors.lastname: Faber
authors.forename: E
authors.initials: E
authors.lastname: Robel-Tillig
authors.forename: C
authors.initials: C
authors.lastname: Vogtmann
authors.forename: H
authors.initials: H
authors.lastname: Stepan
authors.forename: B
authors.initials: B
authors.lastname: Viehweg
mesh_terms: D000653:Amniotic Fluid; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007322:Instillation, Drug; D007752:Obstetric Labor, Premature / Q000000981:diagnostic imaging / Q000628:therapy*; D016104:Oligohydramnios / Q000000981:diagnostic imaging / Q000628:therapy*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal