title: Candidate neuroanatomic substrates of psychosis in old-aged depression.
abstract: 1. The authors investigated the candidate neuroanatomic substrates underlying delusional thought disorder in old-aged depressed patients by using magnetic resonance imaging (MRI), and examined the relationship between volumes for individual brain structures and clinical correlates of particular relevance to depression: executive cognitive impairment and global severity of depression. 2. MR morphometry was performed on nineteen deluded depressed patients and 26 non-deluded depressed patients, all older than 55 years of age. Subjects were administered a neuropsychological test battery and measures of depression. 3. The absolute volume of prefrontal cortex (PFC) was smaller in the deluded depressed group than in non-deluded depressed group (131.79 +/- 37.26 ml vs. 152.65 +/- 26.13 ml, p = 0.03); a difference that was statistically significant even after adjusting for the effect of whole brain volume (p = 0.01). No group differences were observed in the volumes of the basal ganglia, the temporal lobes, the superior temporal gyri, the amygdala-hippocampal complex, the lateral ventricles, or whole brain. The relative volume of PFC correlated inversely and significantly with the index of Wisconsin Card Sorting Test (WCST) performance (r = -0.76, p < 0.01) in depressed patients. 4. PFC may be one of the candidate neuroanatomic substrates underlying delusional thought disorder in old-aged depression.
authors.affiliation: Department of Neuropsychiatry, Samsung Medical Center, College of Medicine, Sungkyunkwan University, Seoul, Korea.
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: B L
authors.initials: BL
authors.lastname: Kim
authors.forename: S E
authors.initials: SE
authors.lastname: Sohn
authors.forename: S W
authors.initials: SW
authors.lastname: Lim
authors.forename: D G
authors.initials: DG
authors.lastname: Na
authors.forename: C H
authors.initials: CH
authors.lastname: Paik
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
authors.forename: B J
authors.initials: BJ
authors.lastname: Carroll
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D000679:Amygdala / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology / Q000523:psychology; D003702:Delusions / Q000473:pathology / Q000523:psychology; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000473:pathology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D014055:Tomography, Emission-Computed