The First Efficient Iodination of Unactivated Aliphatic Hydrocarbons.
No heavy metals, no enzymes, and a simple protocol: the direct iodination of aliphatic hydrocarbons, which has not been possible to date, can now be carried out in multiphase systems [see for example Eq. (1)]. In situ generated tetraiodomethane serves as a key intermediate in this selective radical chain reaction initiated by a single electron transfer. This room-temperature, efficient transformation is highly regioselective, easy to work-up, and hence widely applicable.
Schreiner
PR
Institut für Organische Chemie der Universität, Tammannstrasse 2, D-37077 Göttingen (Germany).
Lauenstein
O
Butova
ED
Fokin
AA