title: Influenza vaccines: antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population.
abstract: The humoral immune response generated by two commercial influenza vaccines was evaluated in a randomised, double-blind trial performed in the Public Department of Dolo Health District (North-east Italy) during the winter season 1997-1998. Ninety-eight subjects were immunised with a split virus vaccine and ninety-six with a MF59-adjuvanted subunit virus vaccine (SU/MF59). The pre- and postvaccination (approximately 30 days) antibody titres were determined by hemagglutination inhibition test (HI). After immunisation protective titre rates (> or = 1:40) were near 100% against virus A strain and 82.5% against B strain. Both vaccines caused significant rises in geometric mean antibody titres (GMTs); however, people who received SU/MF59 vaccine were found to develop a greater immune response compared to the group immunised with SVV. According to logistic regression analysis the unprotective prevaccination immune status and the use of SU/MF59 were identified as independent factors significantly increasing the response to immunisation.
authors.affiliation: Institute of Hygiene, University of Padua, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Menegon
authors.forename: V
authors.initials: V
authors.lastname: Baldo
authors.forename: C
authors.initials: C
authors.lastname: Bonello
authors.forename: D
authors.initials: D
authors.lastname: Dalla Costa
authors.forename: A
authors.initials: A
authors.lastname: Di Tommaso
authors.forename: R
authors.initials: R
authors.lastname: Trivello
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000917:Antibody Formation; D004311:Double-Blind Method; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D007252:Influenza Vaccines