title: Amantadine revisited: an open trial of amantadinesulfate treatment in chronically depressed patients with Borna disease virus infection.
abstract: Amantadinesulfate is a well known substance which has proven useful in the treatment and prophylaxis of viral infections, in treating symptoms of Parkinson's disease, cocaine dependence, and apathy in multiple sclerosis. It has also been reported as having mild antidepressive effects not sufficient to warrant its use as an antidepressant. Striking antidepressive effects in some patients have been attributed to its antiviral activity against human Borna disease virus (BDV) infection which is frequently seen in patients with depressive episodes. In this 8 to 12 week open study of oral amantadine in 30 depressed patients with various states of BDV infection we found a significant antidepressive response in 19 of 30. Peripheral BDV antigen indicating acute infection was cleared in both responders and non-responders, but only in responders peripheral infection was significantly reduced.
authors.affiliation: Department of Gerontopsychiatry, Freie Universität Berlin, Germany. ferszt@zedat.fu-berlin.de
authors.forename: R
authors.initials: R
authors.lastname: Ferszt
authors.forename: K P
authors.initials: KP
authors.lastname: Kühl
authors.forename: L
authors.initials: L
authors.lastname: Bode
authors.forename: E W
authors.initials: EW
authors.lastname: Severus
authors.forename: B
authors.initials: B
authors.lastname: Winzer
authors.forename: A
authors.initials: A
authors.lastname: Berghöfer
authors.forename: G
authors.initials: G
authors.lastname: Beelitz
authors.forename: B
authors.initials: B
authors.lastname: Brodhun
authors.forename: B
authors.initials: B
authors.lastname: Müller-Oerlinghausen
authors.forename: H
authors.initials: H
authors.lastname: Ludwig
mesh_terms: D000547:Amantadine / Q000627:therapeutic use*; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D001890:Borna Disease / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D003863:Depression / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000998:Antiviral Agents; D000547:Amantadine