Motor cortex activation in Parkinson's disease: dissociation of electrocortical and peripheral measures of response generation.
This study investigated characteristics of motor cortex activation and response generation in Parkinson's disease with measures of electrocortical activity (lateralized readiness potential [LRP]), electromyographic activity (EMG), and isometric force in a noise-compatibility task. When presented with stimuli consisting of incompatible target and distractor elements asking for responses of opposite hands, patients were less able than control subjects to suppress activation of the motor cortex controlling the wrong response hand. This was manifested in the pattern of reaction times and in an incorrect lateralization of the LRP. Onset latency and rise time of the LRP did not differ between patients and control subjects, but EMG and response force developed more slowly in patients. Moreover, in patients but not in control subjects, the rate of development of EMG and response force decreased as reaction time increased. We hypothesize that this dissociation between electrocortical activity and peripheral measures in Parkinson's disease is the result of changes in motor cortex function that alter the relation between signal-related and movement-related neural activity in the motor cortex. In the LRP, this altered balance may obscure an abnormal development of movement-related neural activity.
Praamstra
P
P
Department of Neurology, University Hospital Nijmegen, The Netherlands.
Plat
E M
EM
Meyer
A S
AS
Horstink
M W
MW
D000368:Aged; D001767:Blinking / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology; D009622:Noise / Q000009:adverse effects; D010300:Parkinson Disease / Q000503:physiopathology*; D011596:Psychomotor Disorders / Q000175:diagnosis; D011930:Reaction Time; D013997:Time Factors