Mossy fiber involvement in progressive supranuclear palsy.
The cerebellar cortex of progressive supranuclear palsy (PSP) cases exhibited a characteristic pathology which occurred neither in healthy aged individuals nor in cases of fully developed Alzheimer's disease. All of the 11 PSP cases studied reveal altered mossy fiber excrescences containing abnormal and hyperphosphorylated tau protein. Moreover, this abnormal material also appeared in cerebellar oligodendrocytes. Accordingly, there is not only the destruction of the cerebellar output system, which is already known, but also the involvement of the cerebellar input system.
Arai
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Department of Anatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D-60590 Frankfurt am Main, Germany.
Braak
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de Vos
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Jansen Steur
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EN
Braak
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H
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D000544:Alzheimer Disease / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000378:metabolism / Q000473:pathology*; D016874:Neurofibrillary Tangles / Q000473:pathology; D009929:Organ Size; D012727:Sex Characteristics; D016622:Silver Staining; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism
D016875:tau Proteins