title: Bone changes in leprosy patients with disabilities/deformities (a clinico-radiological correlation).
abstract: One hundred and ten leprosy patients (96 males and 14 females, mean age 45.3 years) with disabilities/deformities were examined radiologically to evaluate bone changes and correlating them with clinical parameters. Most patients (98) had paucibacillary leprosy. The mean duration of leprosy was 7.4 years and that of deformity was 4.1 years. Ten patients presented with reaction. Seventy-five (68.2%) patients had received a full course of antileprosy treatment. The overall prevalence of bone changes was 87.3% (96 patients); specific, non-specific, osteoporotic and facial changes were seen in 44.5%, 75.5%, 38.2% and 9.1% of the patients respectively. Among the specific bone changes, primary periosteitis (28.2%) and "bone cysts" (22.7%) were the more common findings. Among the non-specific bone changes, terminal phalangeal absorption (48.2%), soft tissue changes (44.5%) and concentric absorption (32.7%) were more common. Specific bone changes showed a significant (P < 0.05) increase with lack of or incomplete antileprosy treatment. Non-specific bone changes showed significant correlation (P < 0.05) with increasing duration of disease, lack of or partial treatment and rising disability index. Osteoporotic changes showed a significant relationship with rising disability index.
authors.affiliation: Department of Dermatology and STD, JIPMER, Pondicherry.
authors.forename: H
authors.initials: H
authors.lastname: Choudhuri
authors.forename: D M
authors.initials: DM
authors.lastname: Thappa
authors.forename: R H
authors.initials: RH
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Elangovan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006233:Persons with Disabilities / Q000145:classification*; D005147:Facial Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005530:Foot Deformities / Q000000981:diagnostic imaging / Q000473:pathology*; D006226:Hand Deformities / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012720:Severity of Illness Index
chemical_list: D007917:Leprostatic Agents