Bactericidal activity and postantibiotic effect of levofloxacin against anaerobes.
The bactericidal activity and postantibiotic effect (PAE) of levofloxacin against nine anaerobes were determined. Levofloxacin at concentrations of the MIC and twice the MIC was bactericidal at 24 h to five of nine and nine of nine strains, respectively. The PAE of levofloxacin following a 2-h exposure ranged from 0.06 to 2.88 h.
Pendland
S L
SL
Microbiology Research Laboratory, The University of Illinois at Chicago, Chicago, Illinois 60612, USA. pendland@uic.edu
Diaz-Linares
M
M
Garey
K W
KW
Woodward
J G
JG
Ryu
S
S
Danziger
L H
LH
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D013997:Time Factors
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin