[Risk factor of liver disorders caused by flutamide--statistical analysis using multivariate logistic regression analysis].
The antiandrogenic drug, flutamide (Odyne), is widely used in the treatment of carcinoma of prostate. It is well known that flutamide has adverse effects of liver disorders. To ascertain the risk of liver disorders before administering this drug, past history and lifestyle preferences were resurveyed in 123 patients who had been treated with flutamide. The results obtained were assessed in relation to the occurrence of liver disorders by multivariate logistic regression analysis. The incidence of liver disorders was 26% (33/123), with 64% of the disorders occurring within 9 months. The chi-square test for dependent variables revealed that three variables, i.e., body mass index, past history of liver disorders and elevated glutamic-pyruvic transaminase levels were significantly related to the incidence of liver disorders (p > 0.05). Multivariate analysis indicated that a history of liver disorders and elevated alanine aminotransferase (ALT) levels were related to a higher incidence of liver disorders. Elevated ALT levels were associated with a higher incidence of liver disorders and smoking was related to a lower incidence of the liver disorders.
Wada
T
T
Department of Urology, Fuji City General Hospital.
Ueda
M
M
Abe
K
K
Kobari
T
T
Yamazaki
H
H
Nakata
J
J
Ikemoto
I
I
Ohishi
Y
Y
Aizawa
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000726:Androgen Antagonists / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005485:Flutamide / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008019:Life Style; D008107:Liver Diseases / Q000201:enzymology / Q000453:epidemiology; D008297:Male; D015999:Multivariate Analysis; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012044:Regression Analysis; D012307:Risk Factors
D000726:Androgen Antagonists; D005485:Flutamide; D000410:Alanine Transaminase