[The effect of thymic peptides on the development of streptozotocin-induced diabetes mellitus].
Streptosotocin was administered to 21 test animals and 19 control ones. Preventively, the former were given T-activin, the latter--saline. 73% of the test animals were free of hyperglycemia, insulinopenia, activation of lipid peroxidation, morphologic evidence of beta-cell damage. In control animals diabetes mellitus arose in 84% manifesting with marked hyperglycemia, insulinopenia, LPO activation, morphological signs of beta-cell damage, lymphocytic infiltration of the islets. From the results obtained it can be concluded that T-activin has a prominent protective effect against diabetes mellitus (chi-square = 6.34, p < 0.05) which can be explained by its antioxidant and immunotropic activity.
Novikov
V I
VI
Molotkov
O V
OV
Podcheko
A P
AP
Babichev
A V
AV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D007328:Insulin / Q000097:blood; D008297:Male; D010179:Pancreas / Q000473:pathology; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D001786:Blood Glucose; D007328:Insulin; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin