[DNA repair and apoptosis].
DNA damage induced by exo- and endogenous agents triggers two opposite mechanisms--DNA repair and programmed cell death. The latter contains a phase of DNA degradation. Both mechanisms compete for DNA as a substrate and for the cell energy supply. The interaction and competition of these processes influence the pattern of cell death (from pure apoptosis to necrosis). Synergetic and competitive relations between DNA-repair and apoptosis are reviewed.
Tronov
V A
VA
Institute of Chemical Physics, Russian Academy of Sciences, Moscow.
D017209:Apoptosis / Q000235:genetics*; D004249:DNA Damage; D004260:DNA Repair