Limb regeneration: re-entering the cell cycle.
Understanding the cellular plasticity that enables urodeles to regenerate many tissues is important for determining why mammals repair those same tissues with scar. The answer may lie partly in a recently discovered differential responsiveness of urodele cells to factors present in serum at the wound site.
Stocum
D L
DL
Department of Biology Indiana University-Purdue University Indianapolis, Indiana, 46202-3272, USA. dstocum@iupui.edu
D000818:Animals; D002453:Cell Cycle; D002921:Cicatrix / Q000503:physiopathology; D004261:DNA Replication / Q000187:drug effects; D005121:Extremities / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology; D008322:Mammals / Q000502:physiology; D051379:Mice; D018482:Muscle, Skeletal / Q000502:physiology; D010006:Osteoblasts / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D012455:Salamandridae / Q000502:physiology; D013045:Species Specificity; D013917:Thrombin / Q000187:drug effects / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D013917:Thrombin