Controversies at the cytoplasmic face of the cadherin-based adhesion complex.
Cadherin-mediated cell-cell interactions are modulated by protein interactions at the cytoplasmic face of the membrane. Recent work has shown that phosphorylation of both p120(ctn) and beta-catenin affects their interaction with cadherins and the molecular connections to the cytoskeleton. The cytoskeletal connections most probably include interactions between alpha-catenin, and/or alpha-actinin, vinculin, ZO-1, actin and possibly spectrin.
Provost
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Department of Pathology Yale University School of Medicine 310 Cedar Street, New Haven, CT 06510, USA.
Rimm
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D000818:Animals; D051186:Armadillo Domain Proteins; D015820:Cadherins / Q000737:chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D051177:Catenins; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003593:Cytoplasm / Q000648:ultrastructure*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D019281:Dimerization; D029721:Drosophila Proteins; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry; D046911:Macromolecular Substances; D005810:Multigene Family; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013049:Spectrin / Q000378:metabolism; D015534:Trans-Activators; D016596:Vinculin / Q000378:metabolism; D051178:alpha Catenin; D051176:beta Catenin; D000095002:Delta Catenin
D051186:Armadillo Domain Proteins; C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D051177:Catenins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D046911:Macromolecular Substances; D010750:Phosphoproteins; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin; D016596:Vinculin; D013049:Spectrin; D002118:Calcium; D000095002:Delta Catenin; C000722347:CTNND1 protein, human