title: [Therapy for kidney cell carcinoma with cava thrombus. Importance of extracorporeal circulation and prognostic value of cranial tumor extension].
abstract: In approximately 4-10 % of patients presenting with renal cell cancer the transluminal propagation of a tumor thrombus into the vena cava inferior or the right atrium comes to diagnosis. Recent investigations have indicated that the presence of neoplastic extension into the venous system does not reveal independent prognostic value regarding the clinical course of the disease. Although the complete surgical removal of vena cava thrombosis in patients without simultaneously occurring regional lymph node or distant metastases has become a well established treatment modality, several questions concerning this surgical strategy still remain the subject of ongoing discussions. In the present investigation that included 92 patients with renal cell cancer and intracaval neoplastic extension it was clearly demonstrated that the use of cardiopulmonary bypass, deep hypothermia and circulatory arrest preferably during the removal of intracaval thrombosis extending into the right atrium does not result in a substantially increased treatment-related intra- or postoperative mortality. However, in contrast to a previously reported observation this treatment option did not reveal any substantial impact on the long-term survival of the patients following surgical therapy. Accordingly, the cranial extension of intracaval thrombosis was not identified as a biological variable of any prognostic importance for renal cell cancer patients.
authors.affiliation: Klinik und Poliklinik für Urologie, Medizinische Hochschule Hannover.
authors.forename: M
authors.initials: M
authors.lastname: Kuczyk
authors.forename: T
authors.initials: T
authors.lastname: Münch
authors.forename: S
authors.initials: S
authors.lastname: Machtens
authors.forename: T
authors.initials: T
authors.lastname: Wünning
authors.forename: V
authors.initials: V
authors.lastname: Grünewald
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
authors.forename: K
authors.initials: K
authors.lastname: Höfner
authors.forename: U
authors.initials: U
authors.lastname: Jonas
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007680:Kidney Neoplasms / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D011379:Prognosis; D015996:Survival Rate; D019043:Vascular Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D014682:Vena Cava, Inferior / Q000601:surgery