Mitochondria in the life and death of neurons.
A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.
Budd
S L
SL
CNS Research Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Nicholls
D G
DG
D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D017240:Mitochondrial Myopathies / Q000209:etiology; D008959:Models, Neurological; D019636:Neurodegenerative Diseases / Q000209:etiology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D010300:Parkinson Disease / Q000209:etiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate