title: BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II.
abstract: BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
authors.affiliation: Institut Henri Beaufour, Les Ulis, France.
authors.forename: O
authors.initials: O
authors.lastname: Lavergne
authors.forename: J
authors.initials: J
authors.lastname: Harnett
authors.forename: A
authors.initials: A
authors.lastname: Rolland
authors.forename: C
authors.initials: C
authors.lastname: Lanco
authors.forename: L
authors.initials: L
authors.lastname: Lesueur-Ginot
authors.forename: D
authors.initials: D
authors.lastname: Demarquay
authors.forename: M
authors.initials: M
authors.lastname: Huchet
authors.forename: H
authors.initials: H
authors.lastname: Coulomb
authors.forename: D C
authors.initials: DC
authors.lastname: Bigg
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C121907:BN 80927; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D002166:Camptothecin