Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.
The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.
Williams
J T
JT
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. jeffw@darwin.sfbr.org
Begleiter
H
H
Porjesz
B
B
Edenberg
H J
HJ
Foroud
T
T
Reich
T
T
Goate
A
A
Van Eerdewegh
P
P
Almasy
L
L
Blangero
J
J
D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology*; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D018913:Event-Related Potentials, P300 / Q000235:genetics* / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D010375:Pedigree; D019655:Quantitative Trait, Heritable
D000426:Alcohol Dehydrogenase