Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization.
We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The regions of chromosomal gain and loss identified in this study indicate the location of genes that are potentially important in the development and progression of childhood adrenocortical tumours. Finally, the copy number changes identified in childhood tumours are distinctly different to those seen in adult cases (Kjellman et al (1996) Cancer Res 56: 4219-4223), and we propose that this indicates that childhood tumours are of embryonal origin.
James
L A
LA
CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Kelsey
A M
AM
Birch
J M
JM
Varley
J M
JM
D000236:Adenoma / Q000235:genetics*; D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D016158:Genes, p53; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D009154:Mutation; D009693:Nucleic Acid Hybridization
D004273:DNA, Neoplasm