Structure and mechanism of ATP-dependent proteases.
A general paradigm for energy-dependent proteases is emerging: ATP may be used to unfold the substrate and translocate it through a narrow channel within the enzyme into a central proteolytic chamber. Different members of the family present intriguing elaborations on this model.
Schmidt
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Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA.
Lupas
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Finley
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D000255:Adenosine Triphosphate; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000378:metabolism; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
D018832:Molecular Chaperones; D000255:Adenosine Triphosphate; D012697:Serine Endopeptidases