title: Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment.
abstract: OBJECTIVE
  To determine the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in the treatment of hypertrophic scars in lighter- and darker-skinned patients.
  
  
  METHODS
  Prospective, single-blind, randomized, internally controlled, comparison investigation.
  
  
  METHODS
  Large academic dermatology department.
  
  
  METHODS
  Twenty patients with hypertrophic scars (19 completed the laser treatments and 18 completed the silicone gel sheeting treatments).
  
  
  METHODS
  Clinical measurements included hypertrophic scar blood flow, elasticity, and volume. Patients' subjective complaints of pruritus, pain, and burning were also monitored. Histological assessment of fibrosis, number of telangiectasias, and number of mast cells was performed. Statistically significant improvements in clinical measurements and patients' subjective complaints determined treatment success.
  
  
  RESULTS
  Mean scar duration was 32 months (range, 4 months to 20 years). There was an overall reduction in blood flow, volume, and pruritus over time (P = .001, .02, and .005, respectively). However, no differences were detected among treatment and control groups. There was no reduction in pain or burning (0-40 weeks), elasticity (8-40 weeks), or fibrosis (0-40 weeks, n = 5 biopsies) in the treated or control sections of the scars. Unlike in a previous study, the number of mast cells in the scars was similar to the number of mast cells in healthy skin.
  
  
  CONCLUSIONS
  Clinical results demonstrate that the improvements in scar sections treated with silicone gel sheeting and pulsed-dye laser were no different than in control sections.
authors.affiliation: Department of Dermatology, Henry Ford Health System, Detroit, Mich, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Wittenberg
authors.forename: B G
authors.initials: BG
authors.lastname: Fabian
authors.forename: J L
authors.initials: JL
authors.lastname: Bogomilsky
authors.forename: L R
authors.initials: LR
authors.lastname: Schultz
authors.forename: E J
authors.initials: EJ
authors.lastname: Rudner
authors.forename: M L
authors.initials: ML
authors.lastname: Chaffins
authors.forename: G M
authors.initials: GM
authors.lastname: Saed
authors.forename: R L
authors.initials: RL
authors.lastname: Burns
authors.forename: D P
authors.initials: DP
authors.lastname: Fivenson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017439:Cicatrix, Hypertrophic / Q000473:pathology / Q000628:therapy*; D004396:Coloring Agents; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D020034:Silicone Gels; D016037:Single-Blind Method
chemical_list: D004396:Coloring Agents; D020034:Silicone Gels