[Evaluation of the nature of brain tumors using methods of nuclear medicine].
FDG-PET studies permit an assessment of the degree of brain tumour malignancy and detection of tumour recurrence. MIBI-SPECT also affords promising results in this respect. In this work, the diagnostic value of MIBI-SPECT was compared with that of FDG-PET for the determination of primary brain tumours malignancy and the detection of recurrent brain tumours. SPECT and PET examination were carried out within a week in 14 patients (12 males, 2 females, mean age: 40 years, range 16-61 years) with brain tumours. Seven patients had a primary tumour, and in a further 7 MRI or the clinical signs and symptoms let to a suspicion of tumour recurrence. All tumours were verified histologically to be gliomas of grades I-IV. The SPECT and PET images were analysed visually and semiquantitatively. In 3 of the investigated 7 primary glioma patients, there was a visibly enhanced MIBI-positive cases, only one had an increased FDG uptake. In 4 of the 7 tumour recurrence cases, either the MIBI or the FDG uptake was visibly increased. All of these were histologically high-grade gliomas. In the remaining low grade tumours (primary of recurrent), neither MIBI nor FDG revealed a pathologically increased uptake. The intensity of radiopharmaceutical uptake at the site of the tumours was visually and semiquantitatively higher for MIBI that for FDG. It is concluded that MIBI-SPECT is a valuable and simple tool for evaluation of the biological characteristics of brain tumours, showing increased uptake of MIBI according to the malignancy and tumour recurrence of brain tumours.
Ambrus
E
E
Központi Izotópdiagnosztikai Laboratórium, Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Kuncz
A
A
Jánoki
G
G
Vörös
E
E
Szakáll
S
S
Balkay
L
L
Emri
M
M
Trón
L
L
Bodosi
M
M
Csernay
L
L
Pávics
L
L
D000818:Animals; D000829:Animals, Domestic; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009683:Nuclear Medicine; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D017256:Technetium Tc 99m Sestamibi