The dynamics of life and death of malignant lymphocytes.
Normal lymphocytes constantly receive death and survival signals. The balance between these two opposing pathways ensures lymphocyte homeostasis and prevents autoimmunity. This article focuses on the opposing functions of CD40 and Fas receptor/ligand pairs in B-cell lymphoid malignancies and Hodgkin's disease. Understanding these pathways may enhance the future design of immunotherapy against lymphoid malignancies.
Younes
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Department of Lymphoma and Myeloma, UT MD Anderson Cancer Center, Houston, Texas 77030, USA. ayounes@notes.mdacc.tmc.edu
D019013:CD40 Antigens / Q000502:physiology; D016923:Cell Death; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000276:immunology*; D019014:fas Receptor / Q000502:physiology
D019013:CD40 Antigens; D019014:fas Receptor