title: Hypomania in a patient with congenital familial hypothyroidism and mild mental retardation.
abstract: This is a case of a 25-year-old lady with congenital familial hypothyroidism and mild mental retardation presenting with an affective psychosis. The occurrence of hypomanic symptoms in a severe hypothyroid state is unusual and only one other case has been reported. The possible etiological role of a sharp fall in circulating thyroxine levels and its effects on cerebral catecholamines is proposed.
authors.affiliation: Department of Mental Health, Woodbridge Hospital, Singapore.
authors.forename: R
authors.initials: R
authors.lastname: Mahendran
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000209:etiology* / Q000523:psychology; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000235:genetics; D008607:Intellectual Disability / Q000150:complications* / Q000523:psychology; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D013974:Thyroxine