title: Intramuscular desmoid tumor (musculoaponeurotic fibromatosis) in two horses.
abstract: Intramuscular desmoid tumors (musculoaponeurotic fibromatosis) were discovered in two young adult horses. The tumor in one horse was in the lateral cervical musculature, and that in the second horse occurred in the pectoral musculature. Histopathologic features were similar in both horses and included proliferation of fibroblasts and cells expressing muscle actin (myofibroblasts), with extensive dissecting fibrosis within muscle. These features are similar to those of desmoid tumors in humans, particularly those also known as musculoaponeurotic fibromatosis. Dissection of these lesions revealed a single central (horse No. 1) or multiple central (horse No. 2) fluid-filled cavities with associated sterile inflammation. The presence of these cavities supports the hypothesis that equine desmoid tumors are traumatic in origin, possibly occurring at sites of injections or bursal rupture. Surgical excision of the tumor in horse No. 1 was apparently curative, but the extent of the tumor in horse No. 2 precluded surgical excision.
authors.affiliation: College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Valentine
authors.forename: F
authors.initials: F
authors.lastname: Del Piero
authors.forename: R B
authors.initials: RB
authors.lastname: Edwards
mesh_terms: D000818:Animals; D017809:Fatal Outcome; D018222:Desmoid Tumors / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology* / Q000601:surgery; D006736:Horses; D007150:Immunohistochemistry; D019042:Muscle Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D009334:Neck Muscles / Q000473:pathology* / Q000601:surgery; D010369:Pectoralis Muscles / Q000473:pathology* / Q000601:surgery