title: N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Williams
authors.forename: J M
authors.initials: JM
authors.lastname: Bergman
authors.forename: K
authors.initials: K
authors.lastname: Brashear
authors.forename: M J
authors.initials: MJ
authors.lastname: Breslin
authors.forename: C J
authors.initials: CJ
authors.lastname: Dinsmore
authors.forename: J H
authors.initials: JH
authors.lastname: Hutchinson
authors.forename: S C
authors.initials: SC
authors.lastname: MacTough
authors.forename: C A
authors.initials: CA
authors.lastname: Stump
authors.forename: D D
authors.initials: DD
authors.lastname: Wei
authors.forename: C B
authors.initials: CB
authors.lastname: Zartman
authors.forename: M J
authors.initials: MJ
authors.lastname: Bogusky
authors.forename: J C
authors.initials: JC
authors.lastname: Culberson
authors.forename: C
authors.initials: C
authors.lastname: Buser-Doepner
authors.forename: J
authors.initials: J
authors.lastname: Davide
authors.forename: I B
authors.initials: IB
authors.lastname: Greenberg
authors.forename: K A
authors.initials: KA
authors.lastname: Hamilton
authors.forename: K S
authors.initials: KS
authors.lastname: Koblan
authors.forename: N E
authors.initials: NE
authors.lastname: Kohl
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: R B
authors.initials: RB
authors.lastname: Lobell
authors.forename: S D
authors.initials: SD
authors.lastname: Mosser
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Neill
authors.forename: E
authors.initials: E
authors.lastname: Rands
authors.forename: M D
authors.initials: MD
authors.lastname: Schaber
authors.forename: J R
authors.initials: JR
authors.lastname: Huff
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051231:Farnesyltranstransferase; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D004791:Enzyme Inhibitors; D007093:Imidazoles; D010879:Piperazines; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase