[Detection of TT DNA virus (TTV) in blood donors and patients with hepatitis of unclear etiology].
A new human infective agent: TT virus (TTV) has been recently identified. The polymerase chain reaction detected TTV DNA in the sera of 5 (31.3%) out of 16 children with acute hepatitis, 5 (17.2%) out of 29 children and 3 (14.3%) out of 21 adults with liver diseases of unknown etiology, and 18 (13.2%) out of 136 free-of-charge blood donors. These results indicate a high prevalence of TTV infection in Russia and absence of an obvious correlation between this infection and nonA, nonB, nonC hepatitis in examined patients. Phylogenetic analysis of amplified fragments of viral DNA from 3 patients selected at random showed that the isolated strains belong to subtype 1a, most prevalent in the world.
Isaeva
E I
EI
Kuzin
S N
SN
Stepanov
A N
AN
Uchaĭkin
V F
VF
Ross
R S
RS
Rossendorf
M
M
Viazov
S O
SO
L'vov
D K
DK
D000328:Adult; D001782:Blood Donors; D002648:Child; D004266:DNA Virus Infections / Q000453:epidemiology; D004267:DNA Viruses / Q000235:genetics*; D004279:DNA, Viral / Q000097:blood / Q000302:isolation & purification*; D006505:Hepatitis / Q000097:blood* / Q000821:virology; D006801:Humans; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012426:Russia / Q000453:epidemiology
D004279:DNA, Viral