title: Dysidiolide and related gamma-hydroxy butenolide compounds as inhibitors of the protein tyrosine phosphatase, CDC25.
abstract: Synthetic dysidiolide, as well as several related compounds containing a gamma-hydroxybutenolide moiety, were tested in in vitro Cdc25 assays against both synthetic and natural substrates. Contrary to literature values which are in the low micromolar range, we observe only millimolar inhibitory activity for these compounds versus Cdc25 phosphatase.
authors.affiliation: Department of Biochemistry, Mitotix, Inc., Cambridge MA 02139, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Blanchard
authors.forename: D M
authors.initials: DM
authors.lastname: Epstein
authors.forename: M D
authors.initials: MD
authors.lastname: Boisclair
authors.forename: J
authors.initials: J
authors.lastname: Rudolph
authors.forename: K
authors.initials: K
authors.lastname: Pal
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone