[Hemochromatosis--a rare cause of hypogonadism].
A 28-year-old man presented in 1992 with decreased libido and erectile dysfunction. He was found to have central hypogonadism with low serum levels of testosterone, LH and FSH. Computer tomography of the cella turcica was normal. Apart from hypogonadism, the pituitary function was normal. He was successfully treated with testosterone injections. In June 1995, elevated levels of serum ferritin (4,094 micrograms/l) and transferrin saturation (94%) raised suspicion of hemochromatosis. The diagnosis was confirmed by a percutaneous liver biopsy, and treatment started with regular phlebotomies. After three years of treatment the serum levels of LH and testosterone were normalized. Hypogonadism is, except for diabetes mellitus, the most frequent endocrine disturbance in hemochromatosis. It is found almost exclusively in male patients. It is important to exclude hypogonadism in male patients with hemochromatosis, but it is also important to exclude hemochromatosis in male patients with hypogonadism.
Rishaug
U
U
Medisinsk Klinikk, Oslo.
Bell
H
H
Haug
E
E
D000328:Adult; D007172:Erectile Dysfunction / Q000209:etiology / Q000628:therapy; D006432:Hemochromatosis / Q000150:complications*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000628:therapy; D008297:Male; D018962:Phlebotomy