title: Application of mortality prediction systems to individual intensive care units.
abstract: OBJECTIVE
  To evaluate the predictive accuracy of the severity of illness scoring systems in a single institution.
  
  
  METHODS
  A prospective study conducted by collecting data on consecutive patients admitted to the medical intensive care unit over 20 months. Surgical and coronary care admissions were excluded.
  
  
  METHODS
  Veterans Affairs Medical Center at Buffalo, New York.
  
  
  METHODS
  Data collected on 302 unique, consecutive patients admitted to the medical intensive care unit.
  
  
  METHODS
  None.
  
  
  RESULTS
  Data required to calculate the patients' predicted mortality by the Mortality Probability Model (MPM) II, Acute Physiology and Chronic Health Evaluation (APACHE) II and Simplified Acute Physiology Score (SAPS) II scoring systems were collected. The probability of mortality for the cohort of patients was analyzed using confidence interval analyses, receiver operator characteristic (ROC) curves, two by two contingency tables and the Lemeshow-Hosmer chi-square statistic. Predicted mortality for all three scoring systems lay within the 95 % confidence interval for actual mortality. For the MPM II, SAPS II and APACHE II, the c-index (equivalent to the area under the ROC curve) was 0.695 +/- 0.0307 SE, 0.702 +/- 0.063 SE and 0.672 +/- 0.0306 SE, respectively, which were not statistically different from each other but were lower than values obtained in previous studies.
  
  
  CONCLUSIONS
  Although the overall mortality was consistent with the predicted mortality, the poor fit of the data to the model impairs the validity of the result. The observed outcome could be due to erratic quality of care, or differences between the study population and the patient population in the original studies. The data cannot be used to distinguish between these possibilities. To increase predictive accuracy when studying individual intensive care units and enhance quality of care assessments it may be necessary to adapt the model to the patient population.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Veterans Affairs Health Care System of Western New York, State University of New York at Buffalo, New York, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Patel
authors.forename: B J
authors.initials: BJ
authors.lastname: Grant
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D017052:Hospital Mortality; D006787:Hospitals, Veterans; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009518:New York; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index