[Anti-thyroid peroxidase antibody].
Anti-thyroid peroxidase antibody(TPOAb) in patients with autoimmune thyroid diseases was identified with anti-microsomal antibody. Highly sensitive assays of TPOAb using radioimmunoassays and enzyme immunoassays have been developed following a hemagglutination assay technique. TPOAb is present in the serum of almost all patients with Hashimoto's thyroiditis, in more than 70% of those with Graves' disease, and, to a variable degree, in patients with nonthyroid autoimmune diseases and some normal subjects. There is a good correlation between the degree of lymphocytic infiltration of the thyroid gland and the titer of TPOAb. Postpartum thyroiditis, usually a transient disorder, occurs with high frequency in women who have TPOAb. TPOAb, in addition to anti-thyroglobulin antibody, was a clinically useful marker for defining autoimmune thyroid diseases and for detecting an underlying autoimmune process in the thyroid, however, its biological importance remains to be clarified at the present time.
Inukai
T
T
Department of Medicine, Koshigaya Hospital, Dokkyo University School of Medicine.
Takemura
Y
Y
D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007453:Iodide Peroxidase / Q000276:immunology*; D011644:Puerperal Disorders / Q000175:diagnosis; D011863:Radioimmunoassay; D013959:Thyroid Diseases / Q000175:diagnosis*
D001323:Autoantibodies; D007453:Iodide Peroxidase