title: [Portal vein thrombosis in children: clinical and laboratory study of 26 cases].
abstract: Portal vein thrombosis represents one of the most frequent causes of portal hypertension in childhood. The aim of the present study was to describe the clinical and laboratorial characteristics of portal vein thrombosis in pediatric patient. We studied 26 children with diagnosis of portal vein thrombosis through splenoportography (two patients) and ultrasound scan (24 patients) which ages varied from 2 months to 11 years and 4 months (median-5 years and 3 months). Data of the patient history, physical and laboratories examination were used to a retrospective study which was done through medical record analysis. The main complaint of the examination was hematemesis, which was found in 57.6%. In 26.9% a possible risk factor for portal vein thrombosis was found [catheterization of the umbilical vein (four), sepsis (two), omphalitis (one)]. Splenomegaly was present in all cases and the associated illness to portal vein thrombosis were: hepatoportal sclerosis (three), cytomegalovirus infection (two), blastomycosis (two), virus C (two), virus B (one) and virus A (one). The time between the first bleeding and the examination at University of Campinas Hospital, in Campinas, SP, Brazil, varied from 0.23 months to 54 months with a median of 12 months. Only 11.5% of patients underwent the endoscopy with sclerotherapy before going to University of Campinas Hospital. Aminotransferases' activities were considered normal in 20 patients. We could conclude that: 1. The most frequent initial symptom was hematemesis. 2. The known risk factors for portal vein thrombosis were present in about 1/3 of the cases. 3. Laboratorial exams usually indicated absence of hepatocitic lesions. 4. The efforts towards sending the patient to a reference center were late with a delayed diagnostic and with delayed effective therapeutic conduct. 5. In about 50% of the cases there was PVT associated with other hepatic diseases.
authors.affiliation: Departamento de Pediatria e Gastrocentro da Faculdade de Ciências Médicas da Universidade Estadual de Campinas-FCM/UNICAMP. yamada@datakor.com.br
authors.forename: R M
authors.initials: RM
authors.lastname: Yamada
authors.forename: M M
authors.initials: MM
authors.lastname: Antunes
authors.forename: S R
authors.initials: SR
authors.lastname: Cardoso
authors.forename: M de F
authors.initials: Mde F
authors.lastname: Servidoni
authors.forename: G
authors.initials: G
authors.lastname: Hessel
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011169:Portal Vein; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000453:epidemiology / Q000503:physiopathology*