title: [Frequency of embryonal lethality in various strains of Drosophila melanogaster under conditions of destabilization of microtubule apparatus and as affected by heat shock].
abstract: Efficiency of heat shock and three compounds belonging to a group of mitotic poisons (colchicine (Cl), griseofulvin (Gf) and vinblastine (Vb)) in induction of dominant lethal mutations (DLM) in the Canton S wild type strain and the l(l)ts403 temperature-sensitive strain was shown. The mutagen-sensitive strain, mus(2)201Gl, displays no sensitivity to these drugs according to the DLM criterion. Heat shock followed by the Vb and Gf treatment leads to a reduction in the frequencies of DLM. Conversely, a combination of Cl with heat shock increases the yield of DLM.
authors.affiliation: Russian State Pedagogical University, Department of Genetics and Breeding, St. Petersburg, Russia.
authors.forename: P Ia
authors.initials: PIa
authors.lastname: Shvartsman
authors.forename: O A
authors.initials: OA
authors.lastname: Isaenko
mesh_terms: D000818:Animals; D003078:Colchicine / Q000506:poisoning; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000502:physiology*; D005260:Female; D005804:Genes, Lethal; D006118:Griseofulvin / Q000506:poisoning; D006358:Hot Temperature; D008297:Male; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000187:drug effects; D009154:Mutation; D012769:Shock / Q000235:genetics*; D013045:Species Specificity; D014747:Vinblastine / Q000506:poisoning
chemical_list: D006118:Griseofulvin; D014747:Vinblastine; D003078:Colchicine