title: [Body weight change and fluctuation effects on coronary risk factors in the Japanese middle aged men].
abstract: Body weight change (gain or loss) and fluctuation have been associated with an increased risk of cardiovascular disease and death from all causes. In this study, to determinate the effects of weight change and fluctuation on coronary risk factors (CRF) in Japanese, 242 middle-aged men aged 35-58 years, white-collar workers in Tokyo, were followed for 6-years (1990-1995). Height body weight, systolic (SBP) and diastolic (DBP) blood pressure, total cholesterol (TC), high (HDL-C) and low (LDL-C) density lipoprotein cholesterol, triglyceride (TG), and fasting plasma glucose (FPG) were measured each year at an annual health check-up. Over the 6 time periods, body mass index (BMI: body weight (kg) divided by the squared of the height (m)) mean was calculated as a value for the variable BMI level of each subject (BMImean). Direction and magnitude of the change in a subject's BMI was determined by regression of 6 BMI value on time for each individual slope (BMIslope). BMI fluctuation was defined as the root mean square error (BMIRMSE) of a regression line fitted to each individual's BMI value over time. The slopes of the 7 CRF were calculated using each regression equation over time. The CRF slopes were most strongly related to the baseline value of each risk factor, BMImean and BMIslope. BMIRMSE was not related to CRF slopes. In this population, BMI fluctuation had little impact on CRF compared with BMIslope and BMImean. This study results indicate that weight gain and loss has a much greater effect on CRF than does weight fluctuation in Japanese middle-aged men.
authors.affiliation: Department of Health Promotion Sciences, Tokyo University Graduate School of Medicine.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D015992:Body Mass Index; D003327:Coronary Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014041:Tokyo / Q000453:epidemiology; D015430:Weight Gain; D015431:Weight Loss