Cobalamin deficiency associated with erythroblastic anemia and methylmalonic aciduria in a border collie.
Anemia due to cobalamin deficiency is a rare genetic disorder that has been recognized in dogs only recently. This report concerns a 14-month-old border collie that presented for chronic, nonregenerative anemia. Cytological examination of a peripheral blood smear showed the presence of erythroblasts. Serum cobalamin levels were below reference ranges reported for clinically normal dogs. A methylmalonic aciduria was found on urinalysis. These signs are consistent with the anemia in Imerslund-Graesbeck syndrome reported in humans. Anemia due to cobalamin deficiency responds to parenteral vitamin B12 therapy, and affected animals have a good prognosis for recovery.
Morgan
L W
LW
Friendship Hospital for Animals, Washington, DC 20016, USA.
McConnell
J
J
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000652:urine; D004285:Dogs; D005260:Female; D008764:Methylmalonic Acid / Q000652:urine*; D014806:Vitamin B 12 Deficiency / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D017086:beta-Thalassemia / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*
D008764:Methylmalonic Acid