title: Use of clonidine as a component of the peribulbar block in patients undergoing cataract surgery.
abstract: OBJECTIVE
  This study was designed to determine whether administration of clonidine as a component of a peribulbar block enhanced analgesia increased sedation, improved akinesia, or decreased intraocular pressure.
  
  
  METHODS
  A randomized, double-blinded study was undertaken at a University-affiliated tertiary care hospital. Forty outpatients undergoing unilateral cataract surgery by a single surgeon (J.P.) under peribulbar blockade were evaluated. Patients received either 100 microg (1 mL) clonidine or 1 mL preservative-free normal saline mixed with the local anesthetic (7 mL 1% preservative-free lidocaine). A Honan adapter was applied for 10 minutes after block placement. The outcome measures included sedation scores, intraocular pressure (IOP) before and after peribulbar block, need for supplemental block, 24-hour analgesic requirement, and patient satisfaction.
  
  
  RESULTS
  There were no differences between groups with respect to pain, sedation, or satisfaction scores. There was no difference with respect to onset of akinesia. This study revealed no significant difference in baseline IOP and postperibulbar IOP.
  
  
  CONCLUSIONS
  Clonidine did not alter, in any appreciable way, the perioperative course for patients undergoing cataract operations. We do not recommend clonidine as a component of a peribulbar block in patients undergoing cataract extraction operations.
authors.affiliation: Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA.
authors.forename: N R
authors.initials: NR
authors.lastname: Connelly
authors.forename: G
authors.initials: G
authors.lastname: Camerlenghi
authors.forename: M
authors.initials: M
authors.lastname: Bilodeau
authors.forename: S
authors.initials: S
authors.lastname: Hall
authors.forename: S S
authors.initials: SS
authors.lastname: Reuben
authors.forename: J
authors.initials: J
authors.lastname: Papale
mesh_terms: D000759:Adjuvants, Anesthesia; D000368:Aged; D000700:Analgesics; D000772:Anesthesia, Local; D000779:Anesthetics, Local; D000959:Antihypertensive Agents; D002387:Cataract Extraction; D003000:Clonidine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008012:Lidocaine; D008297:Male; D009068:Movement / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D013997:Time Factors
chemical_list: D000759:Adjuvants, Anesthesia; D000700:Analgesics; D000779:Anesthetics, Local; D000959:Antihypertensive Agents; D008012:Lidocaine; D003000:Clonidine