Technetium-99m-HMPAO-labeled leukocyte imaging in patients with seronegative spondyloarthropathies.
OBJECTIVE
Gut inflammation is frequent among patients with seronegative spondyloarthropathies (SSp). The purpose of this study was to evaluate the presence of positive abdominal findings in patients with SSp who did not have clinical symptoms or signs of inflammatory bowel disease (IBD). This represents a new indication for abdominal 99mTc-HMPAO-labeled leukocyte scintigraphy.


METHODS
Eighty-six patients (59 with SSp and 27 controls) were prospectively imaged with 99mTc-HMPAO-labeled leukocytes.


RESULTS
Leukocyte imaging was positive in 33 patients with SSp (56%), 27 of these patients scored between 2+ and 4+ (51%). Four (15%) control patients also had positive findings.


CONCLUSIONS
These findings provide evidence linking SSp with intestinal inflammation. SSp may be an important new indication for 99mTc-HMPAO-labeled autologous leukocyte scintigraphy.
Alonso
J C
JC
Department of Reumatology and Clinical Research Unit, Hospital Complex of Ciudad Real, Spain.
Soriano
A
A
Rubio
C
C
Cuadra
J L
JL
Zarca
M
M
Guerra
P
P
Garcia
A
A
Molino
C
C
D000328:Adult; D001168:Arthritis / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008297:Male; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000000981:diagnostic imaging*; D019690:Technetium Tc 99m Exametazime
D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime