Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models.
The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.
Benoit-Vical
F
F
Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, 34060 Montpellier Cedex 2, France.
Robert
A
A
Meunier
B
B
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008665:Metalloporphyrins / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D008665:Metalloporphyrins; D012717:Sesquiterpenes; D002738:Chloroquine; C031327:artemisinin