[Factor VII deficiency and surgery].
Factor VII deficiency is a rare disorder (1/500,000), with manifestations similar to those experienced by patients with haemophilia. Excessive bleeding during surgical procedure is prevented by factor VII administration. We report two cases of patients presenting a factor VII deficiency who were treated for oncological surgery. In the first patient with a severe congenital factor VII deficiency (8%), a continuous infusion of factor VII prevented the development of perioperative bleeding. In the second case, with a probably acquired factor VII deficiency (33%) related to a leiomyosarcoma, bleeding was prevented by a single preoperative factor VII injection.
Ranchère
J Y
JY
Département d'anesthésie-réanimation, centre de lutte contre le cancer Léon-Bérard, Lyon.
Ménart
C
C
Lienhart
A
A
Attali
O
O
D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control; D005167:Factor VII / Q000008:administration & dosage / Q000627:therapeutic use; D005168:Factor VII Deficiency / Q000150:complications* / Q000151:congenital / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D007680:Kidney Neoplasms / Q000150:complications / Q000601:surgery; D007890:Leiomyosarcoma / Q000150:complications / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D014062:Tongue Neoplasms / Q000601:surgery
D005167:Factor VII