[Echocardiographic findings, pro-ANP and treatment in acute myocardial infarction without overt heart failure].
This study was undertaken to characterise patients without overt heart failure and with a left ventricular ejection fraction > or = 40% 2-7 days following an acute myocardial infarction. Patients with an ejection fraction > or = 40% (n = 868) had a lower prevalence of anterior myocardial infarction (p < 0.001) and lower levels of N-terminal pro-ANP (atrial natriuretic peptide) (p < 0.001) than those with ejection fraction < 40% (n = 305). Patients with ejection fraction > or = 40% had smaller left ventricular volume and mass (p < 0.001). Pro-ANP levels did not correlate significantly with left ventricular volume or ejection fraction in this group. Among patients with ejection fraction < 40%; statistically significant correlations between pro-ANP levels and both ejection fraction and left ventricular endsystolic volume were found. 64% and 61% of patients in the two groups were given thrombolytic treatment. In this study, most patients with acute myocardial infarction had an ejection fraction > or = 40%. Pro-ANP levels were not correlated with the ejection fraction or left ventricular volume. Approximately two thirds of the patients received thrombolytic treatment.
Otterstad
J E
JE
Medisinsk avdeling Vestfold sentralsykehus, Tønsberg.
Hall
C
C
Graving
B
B
Skjaerpe
T
T
Holme
I
I
D000368:Aged; D009320:Atrial Natriuretic Factor / Q000032:analysis; D018849:Controlled Clinical Trials as Topic; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D009664:Norway; D013318:Stroke Volume; D015912:Thrombolytic Therapy; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling
D009320:Atrial Natriuretic Factor