Lineages and transcription factors in the specification of vertebrate primary sensory neurons.
Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.
Anderson
D J
DJ
Howard Hughes Medical Institute Division of Biology 216-76 California Institute of Technology Pasadena, California 91125, USA. barres@stanford.edu
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002460:Cell Line / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology*; D029867:Xenopus Proteins
D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C101907:neurogenin, Xenopus