title: Relative dosimetry using active matrix flat-panel imager (AMFPI) technology.
abstract: The first examination of the use of active matrix flat-panel arrays for dosimetry in radiotherapy is reported. Such arrays are under widespread development for diagnostic and radiotherapy imaging. In the current study, an array consisting of 512 x 512 pixels with a pixel pitch of 508 microm giving an area of 26 x 26 cm2 has been used. Each pixel consists of a light sensitive amorphous silicon (a-Si:H) photodiode coupled to an a-Si:H thin-film transistor. Data was obtained from the array using a dedicated electronics system allowing real-time data acquisition. In order to examine the potential of such arrays as quality assurance devices for radiotherapy beams, field profile data at photon energies of 6 and 15 MV were obtained as a function of field size and thickness of overlying absorbing material (solid water). Two detection configurations using the array were considered: a configuration (similar to the imaging configuration) in which an overlying phosphor screen is used to convert incident radiation to visible light photons which are detected by the photodiodes; and a configuration without the screen where radiation is directly sensed by the photodiodes. Compared to relative dosimetry data obtained with an ion chamber, data taken using the former configuration exhibited significant differences whereas data obtained using the latter configuration was generally found to be in close agreement. Basic signal properties, which are pertinent to dosimetry, have been investigated through measurements of individual pixel response for fluoroscopic and radiographic array operation. For signal levels acquired within the first 25% of pixel charge capacity, the degree of linear response with dose was found to be better than 99%. The independence of signal on dose rate was demonstrated by means of stability of pixel response over the range of dose rates allowed by the radiation source (80-400 MU/min). Finally, excellent long-term stability in pixel response, extending over a 2 month period, was observed.
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109, USA. elmohri@umich.edu
authors.forename: Y
authors.initials: Y
authors.lastname: El-Mohri
authors.forename: L E
authors.initials: LE
authors.lastname: Antonuk
authors.forename: J
authors.initials: J
authors.lastname: Yorkston
authors.forename: K W
authors.initials: KW
authors.lastname: Jee
authors.forename: M
authors.initials: M
authors.lastname: Maolinbay
authors.forename: K L
authors.initials: KL
authors.lastname: Lam
authors.forename: J H
authors.initials: JH
authors.lastname: Siewerdsen
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D004582:Electronics, Medical / Q000295:instrumentation; D005471:Fluoroscopy; D006801:Humans; D010315:Particle Accelerators; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D011874:Radiometry / Q000295:instrumentation* / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted; D011882:Radiotherapy, High-Energy; D012680:Sensitivity and Specificity