Enhancement of memory in cannabinoid CB1 receptor knock-out mice.
We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB receptors play a crucial role in the process of memory storage and retrieval.
Reibaud
M
M
CNS Department, Research Center of Vitry-Alfortville, Rhône-Poulenc Rorer, Vitry-sur-Seine, France. michel.reibaud@rp-rorer.fr
Obinu
M C
MC
Ledent
C
C
Parmentier
M
M
Böhme
G A
GA
Imperato
A
A
D000818:Animals; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011957:Receptors, Opioid / Q000502:physiology*; D013997:Time Factors
D011957:Receptors, Opioid