[The role of the lungs in regulating the generation of active forms of oxygen by the phagocytes, the concentration of immunoglobulins and the complement activity].
Experiments on 25 intact dogs, 2 calves and clinical tests in 45 patients have shown that in the blood of the aorta or pulmonary vein leaving the lungs there is a rise in generation of active oxygen forms by leukocytes, their phagocytic activity, the activity of myeloperoxidase, NADPN-oxidase, complement, immunoglobulins content. As to the liver, kidneys, spleen, no such increased generation of active oxygen forms by leukocytes was registered. The results suggest an important role of the lungs in regulation of free radical activity of leukocytes, their phagocytic ability and thus in anti-infection defense of the body.
Kogan
A Kh
AKh
Manuĭlov
B M
BM
Tsypin
A B
AB
Losev
N I
NI
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D002417:Cattle; D003167:Complement Activation / Q000502:physiology*; D003165:Complement System Proteins / Q000032:analysis; D004285:Dogs; D006330:Heart Defects, Congenital / Q000503:physiopathology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008163:Luminescent Measurements; D008168:Lung / Q000502:physiology*; D008175:Lung Neoplasms / Q000503:physiopathology; D010586:Phagocytes / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013211:Staphylococcus aureus
D007136:Immunoglobulins; D017382:Reactive Oxygen Species; D003165:Complement System Proteins