The influence of nifedipine on blood-brain barrier permeability during bicuculline-induced seizures.
The influence of the calcium channel blocker nifedipine plus bicuculline-induced seizures on the permeability of the blood-brain barrier to protein was studied in rats. Evans-blue was used as a blood-brain barrier tracer. Four groups of rats were studied. Group I: control, Group II: Nifedipine, Group III: bicuculline-induced seizure, Group IV: Nifedipine + seizure. The mean value for Evans-blue dye in the brain was found to be 0.23+/-0.03 mg/g in control animals and 0.32+/-0.06 mg/g in the group of all rats during nifedipine-induced hypotension. This difference between control and hypotensive animals was not statistically significant (p < 0.5). Mean value for Evans-blue dye in the brain was found to be 1.4+/-0.3 mg/g in bicuculline-induced seizure, and 0.73+/-40.2 mg/g in the group of nifedipine plus bicuculline-induced seizures. This difference between Group III and Group IV was found statistically significant (p < .01). The calcium channel blocker nifedipine significantly prevents the blood brain barrier disruption during bicuculline-induced seizure.
Oztaş
B
B
Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
D000818:Animals; D001640:Bicuculline; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002196:Capillaries / Q000187:drug effects / Q000378:metabolism; D003292:Convulsants; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005070:Evans Blue / Q000493:pharmacokinetics*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D010873:Pinocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D002121:Calcium Channel Blockers; D003292:Convulsants; D005070:Evans Blue; D009543:Nifedipine; D001640:Bicuculline