Facile synthesis of N-protected gamma and delta-amino-beta-keto-esters.
The C-acylation of Meldrum's acid by protected amino acids, using isopropenyl chloroformate (IPCF) as the condensing agent, is described. The process is used to synthesize gamma and delta-amino-beta-keto-esters.
Li
B
B
Department of Chemistry, Hunter College / CUNY, New York City, NY 10021, USA.
Franck
R W
RW
D000215:Acylation; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared
D004952:Esters