Depression, coronary events, platelet inhibition, and serotonin reuptake inhibitors.
There is substantial clinical evidence that the incidence of depression and mortality after acute coronary events are strongly related. As mediators of coronary thrombosis, platelets may represent a link between these events, and could be possibly targeted by therapy with serotonin reuptake inhibitors.
Nair
G V
GV
Gurbel
P A
PA
O'Connor
C M
CM
Gattis
W A
WA
Murugesan
S R
SR
Serebruany
V L
VL
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002986:Clinical Trials as Topic; D003863:Depression / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000523:psychology*; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D020280:Sertraline / Q000494:pharmacology / Q000627:therapeutic use*
D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline