title: Myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML) and chronic myeloproliferative disorder (CMPD) in cats.
abstract: Histological, enzyme histochemical and ultrastructural findings in three cases of feline bone marrow neoplasia are described. The following changes were observed: in myelodysplastic syndrome (MDS), a low medullary blast count, strongly atypical (micromegakaryocytic) proliferative megakaryocytopoiesis, hypoplastic erythrocytopoiesis with impairment of differentiation, multifocal extravasation and lymphoid aggregates; in acute myeloid leukaemia (AML), medullary proliferation of undifferentiated cell types; in chronic myeloIproliferative disorder (CMPD), trilinear medullary proliferation with complete cellular maturation, osteomyelosclerosis and extramedullary haemopoiesis. In two cases (MDS, AML), ultrastructural demonstration of C-type virus particles (feline leukaemia virus) suggested a viral aetiology.
authors.affiliation: Institute of Veterinary Pathology, University of Munich, Veterinaerstrasse 13, Munich, D-80539, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Breuer
authors.forename: W
authors.initials: W
authors.lastname: Hermanns
authors.forename: J
authors.initials: J
authors.lastname: Thiele
mesh_terms: D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D002371:Cat Diseases / Q000473:pathology* / Q000821:virology; D002415:Cats; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017988:Gammaretrovirus / Q000302:isolation & purification; D007951:Leukemia, Myeloid / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology / Q000648:ultrastructure; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D009196:Myeloproliferative Disorders / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013154:Spleen / Q000473:pathology
chemical_list: D000914:Antibodies, Viral