title: Basosquamous carcinoma after ultraviolet therapy with artificial sunlight.
abstract: We report a 63-year-old Japanese man with basosquamous carcinoma developing after ultraviolet therapy with artificial sunlight. Because he had had an eczematous lesion on the right leg five years previously, he had received ultraviolet therapy with artificial sunlight from a mercury-quartz lamp for a total of 30 sessions over a 3-year period. Physical examination revealed an irregular erythematous plaque measuring 5 x 6 cm, with slight eruptions and erosions, on the right leg. A brownish plaque, measuring 9 x 12 cm, surrounded the erythematous plaque. Histopathologically, in the nests of atypical cells in the dermis, nuclear palisading was present at the edge of each tumor cluster. Adjacent clusters exhibited transitions to squamous cells and contained horn pearls. Most of the cells of the epidermis and adnexa were atypical, but cells of the normal adnexal epithelium extended over the atypical cells of the epidermis in an umbrella-like fashion in other lesions. We believe that, in the present case, artificial sunlight therapy caused solar keratosis and that this developed into basosquamous carcinoma. To our knowledge, skin cancer developing after ultraviolet therapy with artificial sunlight without PUVA has not previously been reported in the English literature.
authors.affiliation: Division of Dermatology, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Okajima
mesh_terms: D002281:Carcinoma, Basosquamous / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D004485:Eczema / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007869:Leg Injuries / Q000150:complications; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*; D014467:Ultraviolet Therapy / Q000009:adverse effects*