title: Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV.
abstract: The absorbed dose due to photonuclear reactions in soft tissue, lung, breast, adipose tissue and cortical bone has been evaluated for a scanned bremsstrahlung beam of end point 50 MeV from a racetrack accelerator. The Monte Carlo code MCNP4B was used to determine the photon source spectrum from the bremsstrahlung target and to simulate the transport of photons through the treatment head and the patient. Photonuclear particle production in tissue was calculated numerically using the energy distributions of photons derived from the Monte Carlo simulations. The transport of photoneutrons in the patient and the photoneutron absorbed dose to tissue were determined using MCNP4B; the absorbed dose due to charged photonuclear particles was calculated numerically assuming total energy absorption in tissue voxels of 1 cm3. The photonuclear absorbed dose to soft tissue, lung, breast and adipose tissue is about (0.11-0.12)+/-0.05% of the maximum photon dose at a depth of 5.5 cm. The absorbed dose to cortical bone is about 45% larger than that to soft tissue. If the contributions from all photoparticles (n, p, 3He and 4He particles and recoils of the residual nuclei) produced in the soft tissue and the accelerator, and from positron radiation and gammas due to induced radioactivity and excited states of the nuclei, are taken into account the total photonuclear absorbed dose delivered to soft tissue is about 0.15+/-0.08% of the maximum photon dose. It has been estimated that the RBE of the photon beam of 50 MV acceleration potential is approximately 2% higher than that of conventional 60Co radiation.
authors.affiliation: Department of Medical Radiation Physics, Karolinska Institute and University of Stockholm, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Gudowska
authors.forename: A
authors.initials: A
authors.lastname: Brahme
authors.forename: P
authors.initials: P
authors.lastname: Andreo
authors.forename: W
authors.initials: W
authors.lastname: Gudowski
authors.forename: J
authors.initials: J
authors.lastname: Kierkegaard
mesh_terms: D000042:Absorption; D000273:Adipose Tissue / Q000528:radiation effects; D001842:Bone and Bones / Q000528:radiation effects; D001940:Breast / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008297:Male; D008954:Models, Biological; D009010:Monte Carlo Method; D009502:Neutrons; D019047:Phantoms, Imaging; D017785:Photons; D011874:Radiometry / Q000379:methods*; D011878:Radiotherapy / Q000295:instrumentation / Q000379:methods*; D014018:Tissue Distribution