The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.
Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp(3),Leu(8)]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu(8)]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 microg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.
Johnson
M D
MD
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Ko
M
M
Choo
K S
KS
Traynor
J R
JR
Mosberg
H I
HI
Naughton
N N
NN
Woods
J H
JH
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D017421:Sequence Analysis
D009842:Oligopeptides; D010455:Peptides; C087249:phyllolitorin, des-Trp-3,Leu-8-; D001839:Bombesin; D011761:Pyrrolidonecarboxylic Acid