title: An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.
abstract: An olfactory receptor gene was identified near the 3' breakpoint of a naturally occurring deletion (HPFH-1) in the human beta-globin gene cluster on chromosome 11p15.5. The gene encodes an amino acid sequence that is 40 to 51% identical to that of a set of olfactory receptors that have only recently been identified as a distinct family of receptors. There are two orthologous genes in the mouse that encode amino acid sequences that are 73 and 71% identical, respectively, to that encoded by the human gene. This olfactory receptor gene is expressed at the RNA level in human and murine erythroid cells at all stages of development. This aberrant expression is probably due to the location of the gene in the transcriptionally active chromatin domain of the extended beta-globin gene cluster in erythroid cells.
authors.affiliation: Clinical Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Feingold
authors.forename: L A
authors.initials: LA
authors.lastname: Penny
authors.forename: A W
authors.initials: AW
authors.lastname: Nienhuis
authors.forename: B G
authors.initials: BG
authors.lastname: Forget
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002880:Chromosomes, Human, Pair 11; D004247:DNA; D005319:Fetal Hemoglobin; D017353:Gene Deletion; D015870:Gene Expression; D005914:Globins / Q000235:genetics*; D006453:Hemoglobinopathies / Q000235:genetics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D018035:Receptors, Odorant / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012260:Ribonucleases; D017422:Sequence Analysis, DNA; D014407:Tumor Cells, Cultured
chemical_list: C122168:OR52A1 protein, human; D018035:Receptors, Odorant; D005914:Globins; D004247:DNA; D005319:Fetal Hemoglobin; D012260:Ribonucleases