Novel experimental model using free radical-induced emesis for surveying anti-emetic compounds from natural sources.
A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)-glycine (MPG), alpha-tocopherol, and L-ascorbic acid. Tropiseton, a serotonin receptor antagonist, also prevented emesis induced by AAPH. Known anti-emetic drugs and anti-emetic principles from natural sources also showed significant retching inhibition in the experiment using this system.
Yang
Y
Y
Kinoshita
K
K
Koyama
K
K
Takahashi
K
K
Tai
T
T
Nunoura
Y
Y
Watanabe
K
K
D000578:Amidines; D000818:Animals; D000932:Antiemetics / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002645:Chickens; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005609:Free Radicals; D008081:Liposomes; D008297:Male; D016877:Oxidants; D010946:Plants, Medicinal; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000578:Amidines; D000932:Antiemetics; D000975:Antioxidants; D005609:Free Radicals; D008081:Liposomes; D016877:Oxidants; C046728:2,2'-azobis(2-amidinopropane)