title: Activity of vinorelbine on B-chronic lymphocytic leukemia cells in vitro.
abstract: Vinorelbine (VNR) is a new semi-synthetic Vinca rosea alkaloid that has been employed both in combination and as a single agent, showing a significant antitumour activity. Since little is known about VNR in human leukemia, we studied the in vitro cytotoxic effect of VNR on peripheral blood lymphocytes from 18 patients affected by B-chronic lymphocytic leukemia (CLL), employing the INT assay. VNR inhibited fresh B-CLL cells from 15/18 patients in primary cultures, the ID50 doses ranging from 4 ng/ml to 83 micrograms/ml. These data strongly suggest that VNR could be effective in the treatment of B-CLL.
authors.affiliation: Università degli Studi-Azienda Ospedaliera di Careggi, Firenze, Italy.
authors.forename: P A
authors.initials: PA
authors.lastname: Bernabei
authors.forename: I
authors.initials: I
authors.lastname: Landini
authors.forename: B
authors.initials: B
authors.lastname: Bartolozzi
authors.forename: I
authors.initials: I
authors.lastname: Banchelli
authors.forename: A
authors.initials: A
authors.lastname: Degli Innocenti o Nocentini
authors.forename: V
authors.initials: V
authors.lastname: Santini
authors.forename: U O
authors.initials: UO
authors.lastname: Ematologia
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000633:toxicity; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine