title: [The cholinolytic activity of the new anti-arrhythmia preparation Nibentan].
abstract: In the rabbit isolated right atrium and the rat atrial cells, a new class III antiarrhythmic drug Nibentan was shown to exert an anticholinergic effect contrary to Carbachol: the latter decreased the AP duration to 42 +/- 2% of the control whereas Nibentan restored it to 65 +/- 2%. The anticholinergic effect of the drug was found to be due to inhibition of the acetylcholine-activated potassium current: it was decreased by 79 +/- 3% in the rat isolated single atrial cells. In the rabbit isolated sino-atrial node, Nibentan prevented arrhythmogenic effects of vagal stimulation. The new drug may be quite efficient in treatment of flutter and atrial fibrillation.
authors.affiliation: Cardiological Research Centre, Moscow, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Fedorov
authors.forename: T M
authors.initials: TM
authors.lastname: Vinogradova
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Bogdanov
authors.forename: L V
authors.initials: LV
authors.lastname: Rozenshtraukh
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D016275:Atrial Function; D001549:Benzamides / Q000494:pharmacology*; D002469:Cell Separation / Q000379:methods; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008839:Microelectrodes; D009206:Myocardium / Q000166:cytology; D018408:Patch-Clamp Techniques; D011817:Rabbits; D051381:Rats; D012849:Sinoatrial Node / Q000187:drug effects / Q000502:physiology
chemical_list: D000889:Anti-Arrhythmia Agents; D001549:Benzamides; D018680:Cholinergic Antagonists; C105049:nibentan