Post-transcriptional regulation of the parathyroid hormone gene by calcium and phosphate.
Parathyroid hormone messenger RNA levels are regulated by calcium, phosphate and 1,25-dihydroxyvitamin D3. Dietary induced hypocalcaemia increases and hypophosphataemia decreases parathyroid hormone mRNA levels post-transcriptionally. This regulation is mediated by binding of parathyroid cytosolic proteins to the parathyroid hormone mRNA 3'-untranslated region, and in particular the terminal 60 nucleotides of the 3'-untranslated region, thereby determining RNA stability.
Naveh-Many
T
T
Minerva Center for Calcium and Bone Metabolism, Hebrew University Hadassah Medical School, Jerusalem, Israel. tally@cc.huji.ac.il
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D010281:Parathyroid Hormone / Q000235:genetics*; D010710:Phosphates / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics*
D020413:3' Untranslated Regions; D010281:Parathyroid Hormone; D010710:Phosphates; D012333:RNA, Messenger; D002117:Calcitriol; D002118:Calcium