title: Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine.
abstract: The title ketone, a supposed metabolite of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinoli zine (MIQ), was prepared and found different on chromatographic comparison from the isolated metabolite M4. However, the pharmacological screening of this compound evidenced, among others, some interesting properties as inhibition of arachidonic acid induced platelet aggregation and protection from both hypobaric and cyanide induced hypoxia in mice. These activities suggest a possible cerebroprotective action to be further investigated.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Genova, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Grandi
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: A
authors.initials: A
authors.lastname: Sparatore
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000494:pharmacology; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003486:Cyanides / Q000037:antagonists & inhibitors / Q000633:toxicity; D000431:Ethanol; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011807:Quinolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
chemical_list: C121777:9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo(2,3-a)quinolizine; D000897:Anti-Ulcer Agents; D003486:Cyanides; D007211:Indoles; D018696:Neuroprotective Agents; D010975:Platelet Aggregation Inhibitors; D011807:Quinolizines; D016718:Arachidonic Acid; D000431:Ethanol