Leishmanicidal activity of combretastatin analogues and heteroanalogues.
We have investigated the in vitro leishmanicidal activity of representative members from series II-V of combretastatin analogues and heteroanalogues. Most of them exhibited different degrees of activity against various strains of Leishmania spp. The diaryl(heteroaryl)ethane system or the more complex fused heterocyclic stilbenoids, constitute useful skeletal bases to support some kind of antiparasitic activity. Particularly, the incorporation of 2-furyl substituents led to potent antileishmanial compounds, which have been selected for in vivo testing on murine models.
del Rey
B
B
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Salamanca, Spain.
Ramos
A C
AC
Caballero
E
E
Inchaustti
A
A
Yaluff
G
G
Medarde
M
M
Rojas de Arias
A
A
San Feliciano
A
A
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D001632:Bibenzyls / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D013045:Species Specificity; D013267:Stilbenes
D000981:Antiprotozoal Agents; D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin