Selective gene expression increases behavioral sensitivity to cocaine.
Addictive drugs induce a truncated form of fosB in the striatum. A new study shows that mice engineered to mimic this expression pattern are abnormally sensitive to cocaine.
Hyman
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National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, Maryland 20892-9669, USA. shyman@nih. gov.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D005818:Genetic Engineering; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*
D016760:Proto-Oncogene Proteins c-fos; D003042:Cocaine