title: Synthesis of N-[4-(alkyl)cyclohexyl]-substituted benzamides with anti-inflammatory and analgesic activities.
abstract: Two series of N-[4-(alkyl)cyclohexyl]-substituted benzamides, i.e. a series of N-[4-(tert-butyl)cyclohexyl]-substituted benzamides and a series of N-[4-(ethyl)cyclohexyl]-substituted benzamides, were synthesised and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Facoltà di Farmacia, Università di Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: M
authors.initials: M
authors.lastname: Palomba
authors.forename: B
authors.initials: B
authors.lastname: Asproni
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: F
authors.initials: F
authors.lastname: Palagiano
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: G
authors.initials: G
authors.lastname: Motola
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013055:Spectrophotometry, Infrared; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D002351:Carrageenan