title: Evaluation of recent clinical trials in lupus.
abstract: Clinical trials in lupus pose many challenges, ranging from small numbers of subjects to endpoints that are difficult to quantify. Improved standardization of both design and appropriate endpoints is necessary. Recent trials have been small in number, with few randomized controlled trials. These trials have evaluated therapies such as methotrexate, cyclosporine A, bromocriptine, immunoadsorption columns, and hydroxychloroquine withdrawal. With the advent of improved techniques as well as newer therapeutic agents, options for the treatment of lupus should begin to grow over the next several years in a fashion similar to that which has been seen in rheumatoid arthritis.
authors.affiliation: Division of Rheumatology, University of Pittsburgh School of Medicine, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Brooks
authors.forename: M H
authors.initials: MH
authors.lastname: Liang
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D005069:Evaluation Studies as Topic; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000628:therapy*