title: Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation.
abstract: Three clustered mouse chemokine genes, ABCD-1, -2 and -3, are all expressed highly in dendritic cells and, at various levels, in activated B cells. T cell-independently activated B cells express ABCD-1 and -2, but not -3. T cell-dependently activated B cells express all three. ABCD-1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1 and 2. ABCD-2 preferentially attracts type 2 helper T cells, while ABCD-3 does not attract T cells at all. Both ABCD-1 and ABCD-2 bind to the same receptor (CCR4). In addition, ABCD-1 binds to a second, unknown, receptor on a separate T cell population. The three chemokines might guide T cell-independent as well as -dependent responses with two types of CD4+ T cells.
authors.affiliation: Basel Institute for Immunology Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Schaniel
authors.forename: F
authors.initials: F
authors.lastname: Sallusto
authors.forename: C
authors.initials: C
authors.lastname: Ruedl
authors.forename: P
authors.initials: P
authors.lastname: Sideras
authors.forename: F
authors.initials: F
authors.lastname: Melchers
authors.forename: A G
authors.initials: AG
authors.lastname: Rolink
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D054414:Chemokine CCL17; D054422:Chemokine CCL22; D054428:Chemokine CX3CL1; D019742:Chemokines, CC / Q000235:genetics / Q000502:physiology; D020523:Chemokines, CX3C / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008565:Membrane Proteins / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: C106230:CCL17 protein, human; C515482:CCL22 protein, human; C515538:CX3CL1 protein, human; C499538:Ccl17 protein, mouse; C515483:Ccl22 protein, mouse; D054414:Chemokine CCL17; D054422:Chemokine CCL22; D054428:Chemokine CX3CL1; D019742:Chemokines, CC; D020523:Chemokines, CX3C; C515539:Cx3cl1 protein, mouse; D008565:Membrane Proteins; D012333:RNA, Messenger