Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors.
Structure-activity relationship studies on our newly identified anti-HCMV compounds, the 1,6-naphthyridines led to the identification of isoquinoline-6-carboxamides as potent and selective anti-HCMV agents.
Chan
L
L
BioChem Pharma Inc., Québec Canada.
Jin
H
H
Stefanac
T
T
Wang
W
W
Lavallée
J F
JF
Bédard
J
J
May
S
S
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D007546:Isoquinolines / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007546:Isoquinolines