title: Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation.
abstract: Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-alpha production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. The compound significantly inhibited TNF-alpha production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-alpha production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.
authors.affiliation: R & D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam, Kyunggi-Do, Korea. jae.cho@ucl.ac.uk
authors.forename: J Y
authors.initials: JY
authors.lastname: Cho
authors.forename: E S
authors.initials: ES
authors.lastname: Yoo
authors.forename: K U
authors.initials: KU
authors.lastname: Baik
authors.forename: M H
authors.initials: MH
authors.lastname: Park
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D017705:Lignans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D005663:Furans; D017705:Lignans; D014409:Tumor Necrosis Factor-alpha; C105875:eudesmin