Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease.
Parkinson's disease (PD) is a prevalent movement disorder, and 10-30% of PD is familial. Several neurodegenerative disorders which are collectively called frontotemporal dementia and parkinsonism have been mapped to chromosome 17q and mutations in tau have been identified. The clinical and pathological overlap suggests that these related conditions may be due to mutations in tau. We examined linkage to the candidate region on chromosome 17 including and surrounding tau in eight familial PD kindreds. We found no evidence for linkage and excluded the 6cM candidate region which suggest that in our families, PD is not caused by dominant mutations within tau.
Zareparsi
S
S
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA. zarepars@ohsu.edu
Wirdefeldt
K
K
Burgess
C E
CE
Nutt
J
J
Kramer
P
P
Schalling
M
M
Payami
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics
D016875:tau Proteins