title: Attitudes toward prophylactic oophorectomy and screening utilization in women at increased risk of developing hereditary breast/ovarian cancer.
abstract: OBJECTIVE
  The aim of this study was to evaluate ovarian cancer screening uptake and attitudes toward prophylactic oophorectomy in women at risk of developing hereditary breast/ovarian cancer.
  
  
  METHODS
  Ninety-five unaffected women, who approached 1 of 14 familial cancer clinics for advice about their breast/ovarian cancer risk and surveillance and prophylactic options, were assessed in a cross-sectional design when they attended the clinic.
  
  
  RESULTS
  Among high-risk women ages 30 and over who had not had a prophylactic oophorectomy, 48% reported ever having had an ovarian ultrasound, and among women ages 50 and over 23% had had a serum CA 125 test. Twenty-three percent of women would consider, and 27% would not consider, a prophylactic oophorectomy should the genetic test indicate a germline mutation associated with hereditary breast/ovarian cancer, while 38% were unsure. Twelve percent had already undergone a prophylactic oophorectomy. Interest in prophylactic oophorectomy was associated with increased breast/ovarian cancer anxiety (chi(2) = 5.14, P = 0.023), but not objective cancer risk (chi(2) = 0.40, P = 0.53).
  
  
  CONCLUSIONS
  Findings demonstrate that breast/ovarian cancer anxiety, rather than objective risk, is the major factor which determines women's attitude to prophylactic oophorectomy. Women are likely to benefit from interventions aimed at reducing breast/ovarian cancer anxiety. Research on the impact of prophylactic oophorectomy would be helpful in the development of educational strategies and decision aids to assist women who are trying to make a decision under conditions of uncertainty.
authors.affiliation: Hereditary Cancer Clinic, Prince of Wales Hospital, Sydney, NSW 2031.
authors.forename: B
authors.initials: B
authors.lastname: Meiser
authors.forename: P
authors.initials: P
authors.lastname: Butow
authors.forename: A
authors.initials: A
authors.lastname: Barratt
authors.forename: M
authors.initials: M
authors.lastname: Friedlander
authors.forename: M
authors.initials: M
authors.lastname: Gattas
authors.forename: J
authors.initials: J
authors.lastname: Kirk
authors.forename: G
authors.initials: G
authors.lastname: Suthers
authors.forename: I
authors.initials: I
authors.lastname: Walpole
authors.forename: K
authors.initials: K
authors.lastname: Tucker
mesh_terms: D000328:Adult; D001294:Attitude to Health; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control* / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control* / Q000523:psychology; D010052:Ovariectomy; D012307:Risk Factors