title: Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis.
abstract: The degree of calcification as well as the structural changes of the elastic fibres in the ligamentum flavum in patients with degenerative lumbar spinal stenosis were evaluated and the results were compared to those of patients without spinal stenosis. In 21 patients (13 male, 8 female) with lumbar spinal stenosis the ligamentum flavum was removed, histologically processed and stained. The calcification, the elastic/collagenous fibre ratio as well as the configuration of the fibres were evaluated with an image analyzing computer. As a control group, 20 ligaments of 10 human corpses were processed in the same way. The results were statistically analysed using the Mann-Whitney-Wilcoxon test (alpha = 0.05) and the t-test (alpha = 0.05). Nearly all the ligaments of patients with lumbar spinal stenosis were calcified (average 0.17%, maximum 3.8%) and showed relevant fibrosis with decreased elastic/collagenous fibre ratio. There was a significant correlation between age and histological changes (P<0.05). In the control group we only found minimal calcification in 3 of 20 segments (average 0.015%). No relevant fibrosis was found and the configuration of elastic fibres showed no pathologic changes. The results of this study illustrate the important role of histological changes of the ligamentum flavum for the aetiology of lumbar spinal stenosis.
authors.affiliation: Department of Orthopaedics (RKU), University of Ulm, Germany.
authors.forename: P K
authors.initials: PK
authors.lastname: Schräder
authors.forename: D
authors.initials: D
authors.lastname: Grob
authors.forename: B A
authors.initials: BA
authors.lastname: Rahn
authors.forename: J
authors.initials: J
authors.lastname: Cordey
authors.forename: J
authors.initials: J
authors.lastname: Dvorak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D017843:Ligamentum Flavum / Q000473:pathology*; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013130:Spinal Stenosis / Q000473:pathology*