W/O/W Multiple Emulsions Submitted to a Linear Shear Flow: Correlation between Fragmentation and Release.
The present work attempted to apply the theoretical framework described by Taylor to different multiple emulsions under shear. The results were in relatively good agreement with the theory. The correlation between the fragmentation and release studies was well proved. Moreover, these studies showed that mechanisms taking place during the breakup were complex and did not always lead to a total release of the entrapped electrolyte. Some phenomena such as a partial leakage of the internal aqueous compartment or the expulsion of aqueous microglobules covered by a residual lipophilic film were able to restrict the release. Copyright 1999 Academic Press.
Muguet
V
Laboratoire de Dermopharmacologie et Cosmétologie, Laboratoire de Physique Pharmaceutique, Laboratoire de Pharmacie Galénique et de Biopharmacie URA CNRS 1218, Centre d'études Pharmaceutiques, 5 rue J. B. Clément, Châtenay-Malabry, 92296, France
Seiller
M
Barratt
G
Clausse
D
Marty
JP
Grossiord
JL