Relationship between QT interval and heart rate in Alderley Park beagles.
The QT interval and heart rate were measured from the electrocardiogram of 1608 Alderley Park beagles, and the mean QT intervals for 28 values of heart rates between 84 and 192 beats per minute were calculated. These were analysed by linear regression and ranked by Pearson's correlation coefficient for each of eight equations, all of which have been proposed to describe the relationship between QT interval and heart rate. The equation QT=b(square root RR), upon which the calculation of QTc using Bazett's formula is based, did not adequately describe the relationship. QT=b(cube root RR) was a more adequate one-parameter equation. The first-ranked equation was 1/QT=a+b(HR), but its use presents practical and interpretational difficulties; consequently, the second-ranked equation, QT=a+b(log(e)HR), is recommended for routine use.
Davis
A S
AS
Animal Welfare Group, Zeneca Pharmaceuticals, Macclesfield, Cheshire.
Middleton
B J
BJ
D000818:Animals; D004285:Dogs / Q000502:physiology*; D004562:Electrocardiography / Q000662:veterinary; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D016014:Linear Models; D012016:Reference Values