Calcium and strontium metabolic studies in patients on CAPD.
BACKGROUND
Strontium is known to affect calcium metabolism both experimentally and in clinical studies on conditions other than end-stage renal failure (ESRF) and continuous ambulatory peritoneal dialysis (CAPD).


OBJECTIVE
To investigate Sr metabolism in relation to that of Ca in ESRF patients undergoing CAPD, and the possible influence of the duration of treatment.


METHODS
Cross-sectional observational study.


METHODS
University medical center and Institute of Nuclear Physics.


METHODS
Twenty-four patients on CAPD; 14 chronic renal failure (CRF) patients not on dialysis, and 52 healthy controls.


METHODS
Calcium and Sr content of serum, urine or dialysate effluent, and selected dietary products.


RESULTS
Calcium and Sr are absorbed by the intestinal tract of healthy subjects with equal efficiency. Serum Ca levels were considerably lower in CRF patients than in healthy subjects and patients on CAPD (p < 0.001). Serum Sr was significantly higher in both CAPD and CRF patients than in healthy controls (p < 0.001). The Sr/Ca ratio in the sera of the healthy subjects was defined by the preferential excretion of Sr over Ca by the kidney. This preferential excretion was lost during renal failure. During treatment there was a tendency for the uptake of both Ca and Sr to increase.


CONCLUSIONS
Strontium is accumulated in the body during renal failure and CAPD cannot restore normal levels. Considering the varying effects of different doses of Sr on bone metabolism experimentally, it would be interesting to determine by further studies the possible significance of the observed Sr accumulation for renal bone disease.
Apostolidis
N
N
First Propaedeutic Surgical Clinic, Athens University Medical School, Hippokration Hospital, Greece.
Paradellis
T
T
Karydas
A
A
Manouras
A
A
Katirtzoglou
N
N
Mayopoulou-Symvoulidou
D
D
D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003430:Cross-Sectional Studies; D015314:Dialysis Solutions / Q000032:analysis; D005260:Female; D005504:Food Analysis; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013324:Strontium / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000652:urine; D013997:Time Factors
D015314:Dialysis Solutions; D002118:Calcium; D013324:Strontium