title: CD30 positive (non-anaplastic) peripheral T-cell lymphoma of the thyroid gland.
abstract: Primary non-Hodgkin's lymphoma of the thyroid gland are infrequent tumors. They almost exclusively derive from B cells of mucosa-associated lymphatic tissue and only a very small minority of them is represented by T cell lymphomas. CD30 molecule, other than in Hodgkin's and Redd-Sternberg' cells, is strictly associated with anaplastic large cell lymphoma and ALK lymphomas, the latter being identified by the monoclonal antibody ALK1. We report a case of CD30-positive non-anaplastic (ALK1-negative) peripheral T cell lymphoma of the thyroid gland and speculate on aspects concerning diagnosis and the morphologic and immunohistochemical findings.
authors.affiliation: Cattedra e Divisione di Ematologia, Ospedale Sclavo, via Tufi 1, 53100 Siena, Italy. forconif@unisi.it
authors.forename: F
authors.initials: F
authors.lastname: Forconi
authors.forename: M
authors.initials: M
authors.lastname: Bocchia
authors.forename: S
authors.initials: S
authors.lastname: Marconcini
authors.forename: C
authors.initials: C
authors.lastname: Bigazzi
authors.forename: M
authors.initials: M
authors.lastname: Milani
authors.forename: G
authors.initials: G
authors.lastname: Fraternali-Orcioni
authors.forename: F
authors.initials: F
authors.lastname: Lauria
mesh_terms: D000328:Adult; D048429:Cell Size; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000276:immunology*
chemical_list: D017730:Ki-1 Antigen