No evidence for association of multiple sclerosis with the complement factors C6 and C7.
Four genome screens in multiple sclerosis have been completed and each has identified evidence for linkage in the pericentromeric region of chromosome 5. This region encodes a number of candidate genes including those for the complement components C6, C7 and C9. We have used a multiplexed oligoligation assay (OLA) to test single nucleotide polymorphisms (SNPs) from the C6 and C7 genes for evidence of association with multiple sclerosis in our sibling pair families. There was no statistically significant difference in the allele frequencies of these polymorphisms in the index cases from our families when compared with locally derived controls. No evidence for transmission distortion was seen with any of the polymorphisms, or with the haplotype built from the three SNPs from the C7 gene. Despite offering themselves as potential candidates these complement genes appear not to confer susceptibility to multiple sclerosis.
Chataway
J
J
University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK.
Sawcer
S
S
Sherman
D
D
Hobart
M
M
Fernie
B
B
Coraddu
F
F
Feakes
R
R
Broadley
S
S
Gray
J
J
Jones
H B
HB
Clayton
D
D
Goodfellow
P N
PN
Compston
A
A
D001327:Autoimmune Diseases / Q000235:genetics*; D016022:Case-Control Studies; D003183:Complement C6 / Q000235:genetics*; D003184:Complement C7 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic
D003183:Complement C6; D003184:Complement C7