Renal expression of insulin-like growth factor-l in acute renal failure: a preliminary report.
Renal expression of insulin-like growth factor-I (IGF-I) was examined in the specimens obtained at renal biopsy from five patients with acute renal failure (ARF) at the recovering phase. IGF-I peptide and mRNA were demonstrated in the cytoplasm of the epithelial cells of focal proximal tubules in four patients in whom renal function had been ameliorating. The stainings of IGF-I peptide and mRNA were intense in patients with favorable prognosis. Either IGF-I immunoreactivity or mRNA was not detected in the renal tissues in five cases with chronic renal insufficiency and four patients with renal carcinoma. Our preliminary findings suggest that IGF-I is locally produced in the kidney during the recovery period of ARF and might play roles in the repair processes, and extend the experimental observations in animal models into human pathophysiology.
Nishiki
M
M
Department of Medicine, Shimane Medical University, Izumo, Japan.
Murakami
Y
Y
Kawaguchi
M
M
Hashimoto
R
R
Hatta
T
T
Otani
H
H
Kanatsu
K
K
Kajiwara
H
H
Osamura
R Y
RY
Kato
Y
Y
D058186:Acute Kidney Injury / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D006801:Humans; D007124:Immunoenzyme Techniques; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D007668:Kidney / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics
D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I