title: Hypoxemia and hypercapnia during exercise and sleep in patients with cystic fibrosis.
abstract: BACKGROUND
  In patients with cystic fibrosis (CF), it has been proposed that hypoxemia and hypercapnia occur during episodes of stress, such as exercise and sleep, and that respiratory muscle weakness because of malnutrition may be responsible.
  
  
  METHODS
  Pulmonary function, respiratory muscle strength, and nutrition were assessed and correlated with the degree of hypoxemia and hypercapnia during exercise and sleep in 14 patients with CF and 8 control subjects.
  
  
  RESULTS
  Despite no differences in maximum static inspiratory pressure (PImax) between the two groups, the CF group developed more severe hypoxemia (minimum oxyhemoglobin saturation [SpO2], 89 +/- 5% vs 96 +/- 2%; p < 0.001) and hypercapnia (maximum transcutaneous CO2 tension [PtcCO2], 43 +/- 6 vs 33 +/- 7 mm Hg; p < 0.01) during exercise. Similarly, during sleep, the CF group developed greater hypoxemia (minimum SpO2, 82 +/- 8% vs 91 +/- 2%; p < 0.005), although CO2 levels were not significantly different (maximum PtcCO2, 48 +/- 7 vs 50 +/- 2 mm Hg). Within the CF group, exercise-related hypoxemia and hypercapnia did not correlate with FEV1, residual volume/total lung capacity ratio (RV/TLC), PImax, or body mass index (BMI). Hypoxemia and hypercapnia during sleep correlated with markers of gas trapping (RV vs minimum arterial oxygen saturation [r = -0.654; p < 0.05]), RV vs maximum PtcCO2 (r = 0.878; p < 0.001), and RV/TLC vs maximum PtcCO2 (r = 0.790; p < 0.01) but not with PImax or BMI.
  
  
  CONCLUSIONS
  Patients with moderately severe CF develop hypoxemia and hypercapnia during exercise and sleep to a greater extent than healthy subjects with similar respiratory muscle strength and nutritional status. Neither respiratory muscle weakness nor malnutrition are necessary to develop hypoxemia or hypercapnia during exercise or sleep.
authors.affiliation: Department of Respiratory Medicine and Monash University Medical School, Alfred Hospital, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Bradley
authors.forename: P
authors.initials: P
authors.lastname: Solin
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: D
authors.initials: D
authors.lastname: Johns
authors.forename: E H
authors.initials: EH
authors.lastname: Walters
authors.forename: M T
authors.initials: MT
authors.lastname: Naughton
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000502:physiology; D003550:Cystic Fibrosis / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000150:complications*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D009752:Nutritional Status; D005082:Physical Exertion; D011653:Pulmonary Diffusing Capacity; D015656:Respiratory Mechanics; D012132:Respiratory Muscles / Q000503:physiopathology; D012890:Sleep
chemical_list: D002245:Carbon Dioxide