title: Diphosphoinositol polyphosphates: the final frontier for inositide research?
abstract: The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully controlled. Cellular levels of the diphosphoinositol polyphosphates are regulated by cAMP and cGMP in a protein kinase-independent manner. These inositides can also sense a specific mode of intracellular Ca2+ pool depletion. In this review, we will argue that these are characteristics of highly significant cellular molecules.
authors.affiliation: Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Safrany
authors.forename: J J
authors.initials: JJ
authors.lastname: Caffrey
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: S B
authors.initials: SB
authors.lastname: Shears
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000378:metabolism; D007295:Inositol Phosphates / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D010766:Phosphorylation; D015398:Signal Transduction
chemical_list: D007295:Inositol Phosphates; D017766:Acid Anhydride Hydrolases; C116368:diphosphoinositol polyphosphate phosphohydrolase