Comparison of effects on colonic motility and stool characteristics associated with feeding olestra and wheat bran to ambulatory mini-pigs.
The goal of this study was to compare the stool-softening effects of olestra and wheat bran and to determine if changes in patterns of propagating colonic motility were associated with the observed stool softening. Mini-pigs were fed chow (control) or chow supplemented with olestra (80 g/day) or wheat bran (80 g/day) for four days. Proximal colonic motility was monitored continuously, stool viscosity and fecal output measured daily, and cecal-to-anal transit time determined. Compared to controls, olestra and wheat bran significantly softened stool but had no effect on fecal wet weight or colonic transit time. Neither olestra nor wheat bran changed the number of propagating contractions per day, amplitude, motility index, propagation velocity, or the relative distribution of fast and slow propagating contractions. Our data suggest that the stool-softening effects of olestra and wheat bran are not due to direct stimulation of propagating contractions in the colon of the mini-pig.
Greenwood-Van Meerveld
B
B
Oklahoma Foundation for Digestive Research Basic Science Labs., VA Medical Center, Oklahoma City 73104, USA.
Neeley
D E
DE
Tyler
K R
KR
Peters
L J
LJ
McRorie
J W
JW
D000818:Animals; D003106:Colon / Q000187:drug effects; D004043:Dietary Fiber / Q000494:pharmacology*; D019358:Fat Substitutes / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature; D014783:Viscosity
D004043:Dietary Fiber; D019358:Fat Substitutes; D005227:Fatty Acids; D013395:Sucrose; C013692:sucrose polyester