[Graft vs host disease and cytomegalovirus: looking for common pathogenetic link based on discussion about viral super-antigens].
Acute graft-versus-host reaction (GVH) is the most severe complication of allogeneic bone marrow transplantation. It has been shown that higher morbidity and heavier course refers to cytomegalovirus (CMV) seropositive recipients who obtain bone marrow from seronegative donors. In this work hypothetical model linking pathogenesis of acute GVH to CMV infection is discussed. CMV superantigen is postulated to trigger the immunological reaction. Antigen presenting cells of the host expose it on their surface which results in activation of allogeneic T lymphocytes.
Giebel
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D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D006086:Graft vs Host Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D018089:Superantigens / Q000276:immunology*
D018089:Superantigens