Gene frequencies of human platelet antigens in the Tunisian population.
Gene frequencies for the human platelet antigens HPA-1, -3 and -5 in the Tunisian population were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on 93 volunteer blood donors (78 were tested for HPA-1, 90 for HPA-3 and 93 for HPA-5). This study shows the highest frequencies of the HPA-1b (0.25) and HPA-5b (0.22) yet recorded. These antigens are considered as markers of a high risk of platelet alloimmunisation in other populations, and for this reason particular attention should be paid in the case of pregnancy or blood transfusion in this population. The 9 base pair deletion located in intron 21 of the GPIIb gene associated with HPA-3b determinant is present in this population. No individual showed the polymorphism associated with HPA-1b (T-->G at codon 40 of the GPIIIa).
Mojaat
N
N
Centre National de Transfusion Sanguine, Tunis, Tunisia.
Halle
L
L
Proulle
V
V
Hmida
S
S
Ben Hamed
L
L
Boukef
K
K
Kaplan
C
C
D016824:Antigens, Human Platelet / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000276:immunology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D014416:Tunisia
D016824:Antigens, Human Platelet