title: Mortality and need for reoperation in patients with mild-to-moderate asymptomatic aortic valve disease undergoing coronary artery bypass graft alone.
abstract: BACKGROUND
  Patients presenting for coronary artery bypass graft (CABG) surgery may have concurrent asymptomatic aortic stenosis (AS) or aortic insufficiency (AI). This retrospective study was performed to evaluate outcomes in patients with aortic valve disease undergoing CABG with or without aortic valve replacement (AVR).
  
  
  METHODS
  Study groups included 414 patients undergoing combined AVR and CABG (AVR-CABG group) and 62 patients with asymptomatic mild-to-moderate AS, AI, or both undergoing CABG but not AVR (CABG group). End points included 30-day mortality rate, time to cardiac mortality, time to all-cause mortality, and time to aortic valve reoperation. Reoperation refers to surgery for replacement of the native aortic valve in the CABG group or replacement of the prosthetic aortic valve in the AVR-CABG group. Important patient characteristics affecting outcomes were determined by using Cox proportional-hazard analysis. These variables were then included in multivariable analyses by using logistic regression analysis and Cox proportional-hazard modeling to compare outcomes between each patient group.
  
  
  RESULTS
  No difference was seen in any of the mortality end points between the CABG group and the AVR-CABG group after controlling for significant differences between the groups. However, the need for reoperation for AVR was significantly higher for the CABG group than the AVR-CABG group. For patients followed for up to 6 years, the estimated need for aortic valve reoperation was 24.3% in the CABG group versus 3% in the AVR-CABG group.
  
  
  CONCLUSIONS
  On the basis of these results, patients with asymptomatic AS or AI should be considered for AVR at the time of CABG.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hochrein
authors.forename: J C
authors.initials: JC
authors.lastname: Lucke
authors.forename: J K
authors.initials: JK
authors.lastname: Harrison
authors.forename: T M
authors.initials: TM
authors.lastname: Bashore
authors.forename: W G
authors.initials: WG
authors.lastname: Wolfe
authors.forename: R H
authors.initials: RH
authors.lastname: Jones
authors.forename: J E
authors.initials: JE
authors.lastname: Lowe
authors.forename: W D
authors.initials: WD
authors.lastname: White
authors.forename: D D
authors.initials: DD
authors.lastname: Glower
mesh_terms: D000368:Aged; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency / Q000453:epidemiology* / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000453:epidemiology* / Q000601:surgery; D016022:Case-Control Studies; D001026:Coronary Artery Bypass / Q000401:mortality; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D016015:Logistic Models; D016016:Proportional Hazards Models; D012086:Reoperation; D015996:Survival Rate