title: Bactericidal activity and postantibiotic effect of levofloxacin against anaerobes.
abstract: The bactericidal activity and postantibiotic effect (PAE) of levofloxacin against nine anaerobes were determined. Levofloxacin at concentrations of the MIC and twice the MIC was bactericidal at 24 h to five of nine and nine of nine strains, respectively. The PAE of levofloxacin following a 2-h exposure ranged from 0.06 to 2.88 h.
authors.affiliation: Microbiology Research Laboratory, The University of Illinois at Chicago, Chicago, Illinois 60612, USA. pendland@uic.edu
authors.forename: S L
authors.initials: SL
authors.lastname: Pendland
authors.forename: M
authors.initials: M
authors.lastname: Diaz-Linares
authors.forename: K W
authors.initials: KW
authors.lastname: Garey
authors.forename: J G
authors.initials: JG
authors.lastname: Woodward
authors.forename: S
authors.initials: S
authors.lastname: Ryu
authors.forename: L H
authors.initials: LH
authors.lastname: Danziger
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin