title: Evaluation of acoustic rhinometry in a nasal provocation test with allergen.
abstract: BACKGROUND
  The objective was to validate acoustic rhinometry (AR) in a nasal challenge with allergen.
  
  
  METHODS
  Nasal response to allergen provocation was based on clinical and symptom scores, cross-sectional changes of the nasal mucosa as measured by AR with the Rhinoklack system, and peak nasal inspiratory flow (PNIF), in atopic and nonatopic volunteers.
  
  
  RESULTS
  After allergen challenge, mean variation in minimal cross-sectional area (deltaMCA), as measured by AR, or in peak nasal inspiratory flow (deltaPNIF) in nonatopic volunteers, was -0.4+/-14.3% and 5.2+/-15.7%, respectively, compared to baseline. This allowed the determination of a reaction threshold of -29% for deltaMCA and of -26% for deltaPNIF. All but one of the 30 atopic patients reached the AR reaction threshold, whereas all patients reached the PNIF reaction threshold. AR and PNIF closely correlated with clinical and symptom scores for nasal congestion, since there was no significant difference at reaction threshold between both methods.
  
  
  CONCLUSIONS
  In an allergen provocation test, AR appears to be as specific and sensitive as peak nasal inspiratory flow, with the advantage of being independent of the patient's active cooperation. Discrepancies between both methods emphasize the role of nasal cavity anatomy in measuring nasal congestion by AR.
authors.affiliation: Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Ganslmayer
authors.forename: F
authors.initials: F
authors.lastname: Spertini
authors.forename: F
authors.initials: F
authors.lastname: Rahm
authors.forename: M H
authors.initials: MH
authors.lastname: Terrien
authors.forename: B
authors.initials: B
authors.lastname: Mosimann
authors.forename: A
authors.initials: A
authors.lastname: Leimgruber
mesh_terms: D000162:Acoustics; D000293:Adolescent; D000328:Adult; D000485:Allergens; D004056:Differential Threshold; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology* / Q000503:physiopathology*; D009299:Nasal Provocation Tests; D012123:Pulmonary Ventilation; D012016:Reference Values; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology
chemical_list: D000485:Allergens