Lentiviruses as gene delivery vectors.
Lentivirus vectors are already used as effective gene delivery tools in cells from liver, retina, skeletal muscle and the central nervous system. In the past year, new and exciting data from gene transfer experiments in human hematopoietic progenitor cells have been obtained. Furthermore, new generations of HIV-1 based lentivirus vectors as well as new potentially less pathogenic HIV-2 based vectors have been described; however, old and new obstacles remain to be cleared.
Federico
M
M
Laboratory of Virology Istituto Superiore di Sanità Viale Regina Elena 299 00161, Rome, Italy. federico@virus1.net.iss.it
D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods; D005822:Genetic Vectors; D015497:HIV-1 / Q000235:genetics; D015498:HIV-2 / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000821:virology*; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
D018952:Antigens, CD34; D014764:Viral Proteins