A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.
Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors.
Neznanov
N
N
The Burnham Institute, La Jolla, California 92037, USA.
Man
A K
AK
Yamamoto
H
H
Hauser
C A
CA
Cardiff
R D
RD
Oshima
R G
RG
D000483:Alleles; D000818:Animals; D004268:DNA-Binding Proteins; D005260:Female; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D019278:Matrix Metalloproteinase 3 / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009857:Oncogenes; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012097:Repressor Proteins; D015534:Trans-Activators / Q000235:genetics*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C107465:ERF protein, human; C494070:Ets2 protein, mouse; D050787:Proto-Oncogene Protein c-ets-2; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D019278:Matrix Metalloproteinase 3