title: [Acute lymphoblastic leukemia with breast infiltration during the second trimester of pregnancy and followed by successful delivery].
abstract: A 27-year-old pregnant woman was admitted to a local hospital because of headache, nausea, and general fatigue. Her blood examination showed leukocytosis, anemia, and thrombocytopenia. She was referred to our hospital in March 1998. Her bone marrow was normocellular with an excess of blasts (89.1%, peroxidase stain(-), PAS stain(-)) that displayed a positive immunophenotype for CD2, CD4, CD5, CD7, CD34, CD38, and CD71. Chromosome analysis revealed complex abnormal karyotypes. The patient was given a diagnosis of acute lymphoblastic leukemia associated with central nervous system and breast infiltration, and received induction chemotherapy during the second trimester of her pregnancy. After she achieved complete remission, a cesarean section was performed, and a healthy baby delivered. Our experience in this case demonstrated that combination chemotherapy during the second trimester of pregnancy is feasible.
authors.affiliation: Department of Clinical Immunology and Hematology, Sapporo City General Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Bohgaki
authors.forename: A
authors.initials: A
authors.lastname: Notoya
authors.forename: M
authors.initials: M
authors.lastname: Mukai
authors.forename: M
authors.initials: M
authors.lastname: Kohno
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001940:Breast / Q000473:pathology*; D002585:Cesarean Section; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D017254:Leukemic Infiltration; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology* / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D012074:Remission Induction