Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues.
Cyclic analogues of neurotensin (NT) C-terminal fragments NT(8-13) and NT(9-13) were produced via intramolecular nucleophilic substitution of the Tyr(11) phenoxide anion on a 6-bromohexanoyl side chain substituted at position 8 or 9 and tested for NT receptor binding affinity.
Lundquist
J T
JT
Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston 29425, USA.
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T A
TA
D000595:Amino Acid Sequence; D006801:Humans; D009496:Neurotensin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000378:metabolism; D011485:Protein Binding; D018028:Receptors, Neurotensin / Q000378:metabolism*
D010446:Peptide Fragments; D018028:Receptors, Neurotensin; D009496:Neurotensin