title: The role of the barostat in human research and clinical practice.
abstract: The barostat is a recently developed device used to study the physiology and pathophysiology of the motor and sensory functions of the gastrointestinal tract. It can monitor volume changes while maintaining a set constant pressure and deliver controlled distensions of gastrointestinal organs. Simultaneously, motility and visceral perception may be assessed. The barostat has contributed to the understanding of physiological processes in the gastrointestinal tract with regard to regulation of tone, compliance, enteric reflexes, sensation and processing of signals to and from the gut. In addition, the barostat has been used to study various gastrointestinal disorders. In functional bowel disorders, objective abnormalities in visceral sensitivity and enteric reflexes have been demonstrated. Numerous other diseases, gastrointestinal in origin as well as systemic diseases affecting the gut, have been studied. In the near future, the barostat may become a clinically useful tool for the objective diagnosis of motor and sensitivity disorders of the gut and for monitoring the effectiveness of therapy.
authors.affiliation: Dept. of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Schaar
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: A A
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D017704:Baroreflex; D004068:Digestive System Physiological Phenomena; D005762:Gastroenterology / Q000295:instrumentation*; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D008365:Manometry / Q000295:instrumentation; D011312:Pressure