Are atopic individuals genetically predisposed to produce a specific protease profile in antigen processing?
Genetic factors play a major role in the development of allergic diseases such as asthma and atopic dermatitis. Since allergic response involves immune processes such as antigen-processing and -presentation, it is conceivable that the genes involved in the regulation of these processes may be crucial in determining an individual's susceptibility to allergic diseases. In this paper, it is proposed that proteases, used in antigen-processing, are involved in the genetic predisposition to allergic diseases.
Ong
P Y
PY
White Memorial Medical Center, Los Angeles, CA, USA.
Hirsch
A T
AT
D000818:Animals; D017951:Antigen Presentation / Q000235:genetics* / Q000502:physiology; D010450:Endopeptidases / Q000096:biosynthesis*; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008957:Models, Genetic
D010450:Endopeptidases