Effect of dexamethasone on bovine airway smooth muscle cell proliferation.
Airway smooth muscle proliferation is a key component of airway wall remodelling that occurs as a consequence of inflammation in asthma. Studies were conducted to examine the effect of dexamethasone on airway smooth muscle cell (ASMC) proliferation in vitro. Dexamethasone (25-250 nM) significantly inhibited DNA synthesis and cell division induced by beta-hexosaminidase A (Hex A, 50 nM) in bovine ASMC. The inhibitory effect of dexamethasone on DNA synthesis was variable depending on the growth factors: significant effect was observed on Hex A and insulin; no significant effect was observed on epidermal growth factor and fetal bovine serum.
Dixon
E R
ER
The Crippled Children's Foundation Research Center at LeBonheur Children's Medical Center, Memphis, Tennessee, USA.
Weinberg
J A
JA
Lew
D B
DB
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001249:Asthma / Q000473:pathology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006965:Hyperplasia; D009130:Muscle, Smooth / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects / Q000473:pathology
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone