[Broadening of the organ specificity of the action of polynucleotide interferon inducers].
Interferon titers in the blood and brain of mice and their protection from the herpes virus were compared after the animal exposure to poly(G).poly(C) duplex, both native and modified with cis-diammine dichloroplatinum (II). It was shown that the duplex platination especially at the level of the poly(G) strand resulted in sharp rising of the interferon titers in the extracts of the animal brain and rearrangement of the types of interferon induced in the brain to predominance of gamma-interferon. The interferonogenesis indices correlated with the duplex protective activity against the herpes virus. It was concluded that the platinum binding could increase the membrane specificity of the duplex and stimulate its penetration through the hematoencephalic barrier. Possible structural changes in the duplex under the action of platinum (II) resulting in the observed effect are discussed.
Aksenov
O A
OA
Research Institute of Pediatric Diseases, Russian Academy of Medical Sciences, St. Petersburg.
Platonova
G A
GA
Timkovskiĭ
A L
AL
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology; D006566:Herpesviridae Infections / Q000188:drug therapy*; D007369:Interferon Inducers / Q000494:pharmacology*; D051379:Mice; D009928:Organ Specificity; D011119:Polynucleotides / Q000494:pharmacology*; D017186:Titrimetry
D007369:Interferon Inducers; D011119:Polynucleotides; D002945:Cisplatin