Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls.
OBJECTIVE
To assess the status of lipidsoluble antioxidants (carotenoids, tocopherols, ubiquinone), retinol and their correlation with TRAP (total radical-trapping antioxidant potential) in patients with Crohn's disease.


METHODS
Prospective case-control study.


METHODS
Clinic of Internal Medicine IV/Department of Gastroenterology and Hepatology, University of Vienna Medical School.


METHODS
Plasma antioxidant concentrations were determined in patients with Crohn's disease (n = 24) to evaluate the antioxidant capacity compared to healthy controls (n = 33). Additionally, plasma TRAP (total radical-trapping antioxidant potential) was measured in 13 patients and 22 controls.


RESULTS
All investigated carotenoids (alpha-carotene, beta-carotene and cryptoxanthin) were significantly decreased in patients with Crohn's disease (10.2 +/- 9.3, 16.2 +/- 12.4 and 7.8 +/- 5.5 microg/dl) compared to controls (13.3 +/- 5.1, 34.7 +/- 18.8 and 48.5 +/- 38.4 microg/dl respectively), whereas gamma-tocopherol and ubiquinone were significantly elevated in patients (0.14 +/- 0.07 microg/dl and 82.3 +/- 41.5 microg/dl, controls: 0.09 +/- 0.04 microg/dl and 60.8 +/- 30.0 microg/dl, respectively). Retinol and alpha-tocopherol did not significantly differ from controls. The total radical-trapping antioxidant potential (TRAP) was significantly lower in patients (1.11 +/- 0.28 micromol/l) compared to controls (1.34 +/- 0.26 micromol/l). Antioxidants were neither related to duration or severity of disease nor to disease activity.


CONCLUSIONS
In patients with Crohn's disease several plasma antioxidant parameters are altered and the total radical-trapping antioxidant potential is decreased.
Genser
D
D
Institute of Nutritional Sciences, University of Vienna, Austria.
Kang
M H
MH
Vogelsang
H
H
Elmadfa
I
I
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000097:blood*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000097:blood* / Q000145:classification; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D012907:Smoking / Q000378:metabolism; D012995:Solubility; D014451:Ubiquinone / Q000097:blood; D014810:Vitamin E / Q000097:blood*
D000975:Antioxidants; D014451:Ubiquinone; D014810:Vitamin E; D002338:Carotenoids