[Morphologic changes in the rat inferior olive after its neurotoxic destruction with different doses of 2-acetylpyridine].
Neurotoxic effect of 3 acetylpyridine administered in different doses to adult outbred albino rats caused morphological changes in neurons of inferior olive: nucleus translocation towards cell body periphery with central chromatolysis, cytoplasm homogenisation complete dissolution of chromatophilic substance, disappearance of cell contours with glia preservation. The most severe lesion of the nervous tissue was observed in basal olive and dorsal accessory olive in all cases studied. Majority of neurons remained unchanged in medial accessory olive and its subdivisions.
Melik-Musian
A B
AB
Laboratory of Central Nervous System Physiology, L.A. Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan.
Oganesian
E A
EA
Fanardzhian
V V
VV
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity*; D009847:Olivary Nucleus / Q000187:drug effects* / Q000473:pathology; D011725:Pyridines / Q000633:toxicity*; D051381:Rats
D009498:Neurotoxins; D011725:Pyridines; C010835:3-acetylpyridine