title: A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
authors.affiliation: Department of Medicinal Chemistry, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, USA. pjb5890@glaxowellcome.com
authors.forename: P J
authors.initials: PJ
authors.lastname: Brown
authors.forename: D A
authors.initials: DA
authors.lastname: Winegar
authors.forename: K D
authors.initials: KD
authors.lastname: Plunket
authors.forename: L B
authors.initials: LB
authors.lastname: Moore
authors.forename: M C
authors.initials: MC
authors.lastname: Lewis
authors.forename: J G
authors.initials: JG
authors.lastname: Wilson
authors.forename: S S
authors.initials: SS
authors.lastname: Sundseth
authors.forename: C S
authors.initials: CS
authors.lastname: Koble
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
authors.forename: J M
authors.initials: JM
authors.lastname: Chapman
authors.forename: J M
authors.initials: JM
authors.lastname: Lehmann
authors.forename: S A
authors.initials: SA
authors.lastname: Kliewer
authors.forename: T M
authors.initials: TM
authors.lastname: Willson
mesh_terms: D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000819:agonists*; D011345:Fenofibrate / Q000494:pharmacology; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000819:agonists*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*; D016335:Zinc Fingers
chemical_list: D002087:Butyrates; D004268:DNA-Binding Proteins; D000960:Hypolipidemic Agents; D009687:Nuclear Proteins; D010671:Phenylurea Compounds; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C121804:GW 9578; D011345:Fenofibrate