title: Postnatal proliferation of DRG non-neuronal cells in vitamin E-deficient rats.
abstract: Changes in the number of satellite cells in neuron body sheaths in dorsal root ganglia (DRGs) were studied from 1 to 5 months of age in control and in vitamin E-deficient rats; furthermore, the satellite cell proliferation rate was detected in the same groups of animals with immunohistochemistry for 5-bromo-2'-deoxyuridine (BrdU). The number of satellite cells in sheaths of DRG neurons increased in the period of life considered both in control and in vitamin E-deficient rats. Satellite cell proliferation was observed in both groups, but its rate was found to be higher in vitamin E-deficient rats. The results obtained in control rats confirm that mitotic ability is retained by satellite cells in adulthood and show that at least some of newborn satellite cells add to the pre-existing population. The results obtained in vitamin E-deficient rats suggest that a faster turnover in satellite cell population takes place in these animals and support the idea that vitamin E could be an exogenous factor controlling cell proliferation.
authors.affiliation: Istituto di Scienze Morfologiche, Università di Urbino, I-61029 Urbino, Italy. t.cecchini@uniurb.it
authors.forename: T
authors.initials: T
authors.lastname: Cecchini
authors.forename: P
authors.initials: P
authors.lastname: Ferri
authors.forename: S
authors.initials: S
authors.lastname: Ciaroni
authors.forename: R
authors.initials: R
authors.lastname: Cuppini
authors.forename: P
authors.initials: P
authors.lastname: Ambrogini
authors.forename: S
authors.initials: S
authors.lastname: Papa
authors.forename: P
authors.initials: P
authors.lastname: Del Grande
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D002455:Cell Division; D005727:Ganglia, Spinal / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D008297:Male; D008938:Mitosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014811:Vitamin E Deficiency / Q000378:metabolism / Q000473:pathology*
chemical_list: D001973:Bromodeoxyuridine