Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: discrimination between drug and ethanol effects.
The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F2 alpha). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F2 alpha being most efficiently antagonized.
Meister
A
A
Institut für Pharmazie, Universität Regensburg, Germany.
Bernhardt
G
G
Christoffel
V
V
Buschauer
A
A
D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D019686:Lamiaceae; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D010276:Parasympatholytics; D010936:Plant Extracts; D000431:Ethanol