title: Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor.
abstract: OBJECTIVE
  Leptomeningeal disease (LMD) significantly affects the prognosis and treatment of pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Examination of CSF for malignant cells, detection of LMD on spinal magnetic resonance imaging (MRI), or both are the methods routinely used to diagnose LMD. A recent study suggested 100% correlation between CSF and MRI findings in children with medulloblastoma. To determine the validity of this hypothesis, we compared the rate of detection of LMD between concurrent lumbar CSF cytology and spinal MRI performed at diagnosis in patients with medulloblastoma or PNET.
  
  
  METHODS
  As a part of diagnostic staging, 106 consecutive patients newly diagnosed with medulloblastoma or PNET were evaluated with concurrent lumbar CSF cytology and spinal MRI. CSF cytology was examined for the presence of malignant cells and spinal MRI was reviewed independently for the presence of LMD.
  
  
  RESULTS
  Thirty-four patients (32%) were diagnosed with LMD based on CSF cytology, spinal MRI, or both. There were 21 discordant results. Nine patients (8.5%) with positive MRI had negative CSF cytology. Twelve patients (11.3%) with positive CSF cytology had negative MRIs. The exact 95% upper bounds on the proportion of patients with LMD whose disease would have gone undetected using either CSF cytology or MRI as the only diagnostic modality were calculated at 14.4% and 17.7%, respectively.
  
  
  CONCLUSIONS
  With the use of either CSF cytology or spinal MRI alone, LMD would be missed in up to 14% to 18% of patients with medulloblastoma or PNET. Thus, both CSF cytology and spinal MRI should routinely be used to diagnose LMD in patients with medulloblastoma or PNET.
authors.affiliation: Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. maryam.fouladi@stjude.org
authors.forename: M
authors.initials: M
authors.lastname: Fouladi
authors.forename: A
authors.initials: A
authors.lastname: Gajjar
authors.forename: J M
authors.initials: JM
authors.lastname: Boyett
authors.forename: A W
authors.initials: AW
authors.lastname: Walter
authors.forename: S J
authors.initials: SJ
authors.lastname: Thompson
authors.forename: T E
authors.initials: TE
authors.lastname: Merchant
authors.forename: J J
authors.initials: JJ
authors.lastname: Jenkins
authors.forename: J W
authors.initials: JW
authors.lastname: Langston
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: L E
authors.initials: LE
authors.lastname: Kun
authors.forename: R L
authors.initials: RL
authors.lastname: Heideman
mesh_terms: D000293:Adolescent; D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002555:Cerebrospinal Fluid / Q000166:cytology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000473:pathology; D011379:Prognosis; D012680:Sensitivity and Specificity