[Genetic characteristics of variants of human immunodeficiency virus type 1, causing an epidemic among substance abusers in Commonwealth of Independent States countries].
Gag/env nucleotide sequences of human immunodeficiency virus type 1 (HIV-1) variants detected in drug users in Russia, Ukraine, and Belarus are analyzed. Two HIV-1 subtypes A and B circulate in this risk group. Genetic variability within one subtype is no higher than 3.1 and 3.9% for gag and env genes, respectively, suggesting the same source of infection in populations of drug users infected with the same subtype. Recombinant viruses with gagAenvB genotype, genetically related to parental strains of subtypes A and B, circulate in this risk group. This is the first report about HIV-1 recombinant of the two subtypes, for which both parental strains are known, directly confirming the in vivo recombination between different subtypes.
Bobkov
A F
AF
Pokrovskiĭ
V V
VV
Selimova
L M
LM
Ladnaia
N N
NN
Kazennova
E V
EV
Bobkova
M R
MR
Khanina
T A
TA
Kravchenko
A V
AV
Iurin
O G
OG
Saukhat
S R
SR
D017517:Commonwealth of Independent States / Q000453:epidemiology; D015752:Genes, env; D015750:Genes, gag; D005838:Genotype; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D010802:Phylogeny; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications*