title: Preoperative oral granisetron for the prevention of vomiting after strabismus surgery in children.
abstract: OBJECTIVE
  To evaluate the efficacy of oral granisetron for the prevention of postoperative vomiting in children undergoing strabismus surgery.
  
  
  METHODS
  Prospective, randomized, double-masked, placebo-controlled study.
  
  
  METHODS
  A total of 120 children, 4-10 years of age, scheduled for elective strabismus surgery.
  
  
  METHODS
  Patients received oral placebo or granisetron at three different doses (20 microg/kg, 40 microg/kg, 80 microg/kg) 1 hour before surgery.
  
  
  METHODS
  A complete response, defined as no vomiting, no retching, and no need for rescue antiemetic medication, during the first 24 hours after anesthesia was recorded.
  
  
  RESULTS
  A complete response during 0-24 hours after anesthesia occurred in 33% of those who received placebo, 40% who received granisetron 20 microg/kg, 83% who received granisetron 40 microg/kg, and 87% who received granisetron 80 microg/kg (P < 0.05, overall Fisher's exact probability test).
  
  
  CONCLUSIONS
  Preoperative oral granisetron, in doses more than 40 microg/kg, is effective for preventing vomiting after strabismus surgery in children.
authors.affiliation: Department of Anesthesiology, Toride Kyodo General Hospital, Toride City, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D000284:Administration, Oral; D000932:Antiemetics / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009801:Oculomotor Muscles / Q000601:surgery*; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects*; D011300:Preoperative Care / Q000379:methods; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D017829:Granisetron