title: RMPs: recombination/replication mediator proteins.
abstract: Enzymes for DNA replication and recombination need to gain access to single-stranded DNA (ssDNA) but ssDNA-binding proteins (SSBs) present an obstacle to the formation of enzyme-ssDNA replication and recombination complexes. A specialized class of SSBs, which we designate as recombination/replication mediator proteins (RMPs), promotes enzyme- ssDNA assembly by overcoming SSB inhibition. RMPs exhibit strong conservation of function across divergent species, and display species-specific interactions with SSB and enzymes to neutralize the SSB barrier to enzyme-ssDNA assembly.
authors.affiliation: Dept of Biochemistry and Center for X-ray Crystallography, The University of Vermont College of Medicine, Burlington, VT 05405-0068, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Beernink
authors.forename: S W
authors.initials: SW
authors.lastname: Morrical
mesh_terms: D017122:Bacteriophage T4 / Q000235:genetics; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000502:physiology*; D011995:Recombination, Genetic
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins