[Clinical features of deep mycosis in critical care center--comparison of serological tests and cultures for mycosis].
The clinical features of invasive deep mycosis in the critical care center was studied and the usefulness for determinations of plasma (1-->3)-beta-D-glucan, one of the major structural components of fungi, in making the diagnosis of deep mycosis was evaluated in comparison with that of blood culture and candida antigen titer using CAND-tec kit. A total of 92 febrile patients (mean age = 54.5 yr., M/F = 70/22) in our critical care center were enrolled in this study. Seventeen out of the 92 febrile patients (18.5%) were those with deep mycosis. In the deep mycosis group, there were 10 patients with fungal panperitonitis, 5 with fungaemia, one with candidal pneumonia and one with candidal empyema. A total of 52 blood samples were obtained from 17 patients with deep mycosis. Forty five out of the 52 blood samples (86.5%) were positive for serum (1-->3)-beta-D-glucan while only 10 were culture-positive. In contrast, six (15.0%) out of the 40 blood samples were obtained from 17 patients with deep mycosis were positive for candida antigen by CAND-tec kit. In the critical care center, deep mycosis is a common infection and determination of serum concentration of (1-->3)-beta-D-glucan is found to be a very useful examination in screening of deep mycosis with high sensitivity and specificity.
Kawayama
T
T
Department of Respiratory Medicine, Social Insurance Tagawa Hospital.
Oizumi
K
K
D000946:Antigens, Fungal / Q000097:blood*; D002175:Candida / Q000276:immunology; D004632:Emergency Medical Services; D005260:Female; D005936:Glucans / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D047071:beta-Glucans
D000946:Antigens, Fungal; D005936:Glucans; D047071:beta-Glucans; C033363:beta-1,3-glucan