title: Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity.
abstract: Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 60612, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: M J
authors.initials: MJ
authors.lastname: Holterman
authors.forename: D L
authors.initials: DL
authors.lastname: Venton
mesh_terms: D020650:Combinatorial Chemistry Techniques; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D013058:Mass Spectrometry; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010744:Phosphoric Monoester Hydrolases; C031215:betadex