title: Olfactory dysfunction in multiple sclerosis: relation to longitudinal changes in plaque numbers in central olfactory structures.
abstract: Scores on the University of Pennsylvania Smell Identification Test (UPSIT), as well as the numbers of MRI-determined plaques within the inferior frontal and temporal lobes, were obtained on three or four separate occasions in each of five MS patients over an 18- to 20-month period. A close association was observed, longitudinally, between the remission and exacerbation of plaque numbers and UPSIT scores, with more plaques reflecting lower UPSIT scores. These observations further support the hypothesis that olfactory loss in MS is associated with fluctuations in plaque numbers in central olfactory brain regions.
authors.affiliation: Smell & Taste Center, Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Doty
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: L J
authors.initials: LJ
authors.lastname: Mannon
authors.forename: D M
authors.initials: DM
authors.lastname: Yousem
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology*; D009830:Olfactory Bulb / Q000473:pathology* / Q000503:physiopathology*