title: Effective cancer therapy with a single injection of interleukin-2 at the site of the tumour.
abstract: Mice with a severe metastasized tumour burden can be cured with a single local injection of interleukin-2. Such a treatment can also be effective against ocular squamous cell carcinoma in cows and transmissible venereal tumours in dogs. We did not notice any toxic effects of this treatment.
authors.affiliation: Department of Cell Biology and Histology, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, The Netherlands. w.denotter@pobox.accu.uu.nl
authors.forename: W D
authors.initials: WD
authors.lastname: Otter
authors.forename: J
authors.initials: J
authors.lastname: Cadée
authors.forename: R
authors.initials: R
authors.lastname: Gavhumende
authors.forename: C J
authors.initials: CJ
authors.lastname: De Groot
authors.forename: W E
authors.initials: WE
authors.lastname: Hennink
authors.forename: R
authors.initials: R
authors.lastname: Stewart
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005134:Eye Neoplasms / Q000188:drug therapy*; D005260:Female; D015552:Injections, Intralesional; D007376:Interleukin-2 / Q000008:administration & dosage*; D008223:Lymphoma / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012074:Remission Induction; D014407:Tumor Cells, Cultured; D014685:Venereal Tumors, Veterinary / Q000188:drug therapy*
chemical_list: D007376:Interleukin-2