title: Analysis of 57 nonagenarian cancer patients treated by radical radiotherapy: a survey of eight institutions.
abstract: BACKGROUND
  As the human society grows more aged, it is considered important to elucidate factors essential in applying radical radiotherapy (RT) to the elderly, with ages as high as 90 years and greater.
  
  
  METHODS
  A retrospective survey was conducted for patients 90 years of age or older who received radiotherapy with radical intent in eight leading institutions in Japan from 1990 through 1995.
  
  
  RESULTS
  Fifty-seven nonagenarian patients were studied. Their ages ranged up to 98 (median 91) and there was a strong female preponderance (M/F: 16/41). The distribution by site was as follows: head and neck, 16; skin and adnexae, 11; uterine cervix, 7; esophagus, 6. The prevailing histopathological diagnosis was squamous cell carcinoma (34), followed by adenocarcinomas (8). The highest age at RT was 98 years [female, skin cancer, died of senility 2.5 years after treatment, with no evidence of disease (NED)] and the longest survivor is 102 years old (female, glottic cancer T2, age at RT 93, alive NED for 8 years, uses wheel-chair). The rate of completion of treatment was 75% (43/57), if the treatment field was limited to the gross primary tumor volume only and if the cumulative dose was above 80% of the tolerable adult dose. Familial escort was necessary for most of the patients in completing the day-to-day RT.
  
  
  CONCLUSIONS
  Radiotherapy is feasible with radical intent even in the elderly, if the treatment field is limited to the gross primary tumor volume only, if the cumulative dose is above 80% of the tolerable adult dose and if familial support is adequate.
authors.affiliation: Division of Radiology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan. hikeda@east.ncc.go.jp
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: S
authors.initials: S
authors.lastname: Ishikura
authors.forename: M
authors.initials: M
authors.lastname: Oguchi
authors.forename: H
authors.initials: H
authors.lastname: Niibe
authors.forename: A
authors.initials: A
authors.lastname: Yorozu
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: N
authors.initials: N
authors.lastname: Fuwa
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Teshima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D004938:Esophageal Neoplasms / Q000532:radiotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000401:mortality* / Q000532:radiotherapy*; D011379:Prognosis; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000532:radiotherapy; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy