title: Lessons from the rifamycin biosynthetic gene cluster.
abstract: There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of erythromycin. Work on the rifamycin polyketide synthase has revealed a number of features that differ from those seen with DEBS.
authors.affiliation: Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA. floss@chem.washington.edu.
authors.forename: H G
authors.initials: HG
authors.lastname: Floss
authors.forename: T W
authors.initials: TW
authors.lastname: Yu
mesh_terms: D008956:Models, Chemical; D009097:Multienzyme Complexes / Q000378:metabolism; D005810:Multigene Family; D012294:Rifamycins / Q000096:biosynthesis*
chemical_list: D009097:Multienzyme Complexes; D012294:Rifamycins