Propafenone disposition during continuous venovenous hemofiltration.
OBJECTIVE
To determine the extent of removal of propafenone by continuous venovenous hemofiltration (CVVH) in a critically ill pediatric patient.


METHODS
A three-year-old white-Japanese girl was admitted to the critical care unit following cardiac surgery. Her postoperative course was complicated by the development of junctional ectopic tachycardia, requiring propafenone, and acute renal failure, which necessitated the use of CVVH. The serum and ultrafiltrate concentrations of propafenone and its 5-hydroxy metabolite were measured to determine both total and CVVH clearance.


CONCLUSIONS
The data from this case report showed that propafenone was not significantly removed by CVVH. Furthermore, the total clearance of propafenone was not affected by the patient's renal or liver function impairment.
Seto
W
W
Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada. wseto@interlog.com
Trope
A E
AE
Gow
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RM
D058186:Acute Kidney Injury / Q000628:therapy; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D002675:Child, Preschool; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008657:Metabolic Clearance Rate; D011405:Propafenone / Q000097:blood / Q000493:pharmacokinetics*
D000889:Anti-Arrhythmia Agents; D011405:Propafenone