title: Interaction of Qinghaosu (Artemisinin) with Cysteine Sulfhydryl Mediated by Traces of Non-Heme Iron.
abstract: The antimalarial action of 1,2,4-trioxanes such as qinghaosu (QHS) may take place through the mechanism shown schematically: In the presence of cysteine traces of non-heme iron (FeSO(4)) may cleave the peroxy bond of QHS rapidly, and the transient carbon-centered radical can attack the sulfur ligand to form a covalent bond.
authors.affiliation: State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road Shanghai 200032 (China).
authors.initials: Y
authors.lastname: Wu
authors.initials: ZY
authors.lastname: Yue
authors.initials: YL
authors.lastname: Wu