GF 109203X, a selective inhibitor of protein kinase C, impairs retention performance in an operant task.
The effects of post-training administration of GF 109203X (5 and 50 ng i.c.v.), a selective inhibitor of protein kinase C, on retention performance were investigated in a positively reinforced lever press task, in male Swiss mice. Both doses of GF 109203X suppressed the spontaneous improvement of performance observed in control animals between the last 5 min of the acquisition session and the first 5 min of the retention session 24 h later. GF 109203X had no effect on food intake and locomotor activity. These data suggest that GF 109203X selectively interferes with mechanisms underlying post-training organization of information and that protein kinase C is involved in this memory process.
Stemmelin
J
J
Laboratoire d'Ethologie et Neurobiologie, URA 1295 du CNRS, Université Louis Pasteur, Strasbourg, France.
Mathis
C
C
Ungerer
A
A
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008301:Maleimides / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D012153:Retention, Psychology / Q000187:drug effects*
D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D011493:Protein Kinase C; C070515:bisindolylmaleimide I