title: MR angiography with three-dimensional time-of-flight and targeted maximum-intensity-projection reconstructions in the follow-up of intracranial aneurysms embolized with Guglielmi detachable coils.
abstract: OBJECTIVE
  Intra-arterial contrast angiographies are generally used to confirm treatment results of endovascular neurointerventions such as aneurysm obliteration. We compared MR angiography with digital subtraction angiography (DSA) as a follow-up technique for the detection of aneurysmal remnant cavities and arterial patency in patients treated for intracranial aneurysms with Guglielmi detachable coils (GDCs).
  
  
  METHODS
  In 20 consecutive patients, follow-up MR angiography and routine intra-arterial cerebral angiography were performed on the same day 1 to 7 months (mean, 4.5 months) after embolization with GDCs. MR angiographic data were postprocessed for subvolume maximum intensity projections centered on the region of the treated aneurysm. Hard copies of both imaging studies were interpreted independently in a blinded fashion to record and compare remnant cavities, location of residual flow, and adjacent arterial narrowing, using DSA as the standard of reference. The interpreters also established an occlusion grade for the treated aneurysms as evidenced on DSA images and evaluated MR angiograms for artifactual effects.
  
  
  RESULTS
  Overall sensitivity and positive predictive value of MR angiography in revealing aneurysmal remnant cavities were both 90%. Specificity in ruling out a remnant cavity with MR angiography was 91%. One remnant cavity was missed by MR angiography, and in five patients, false adjacent arterial encroachments were reported.
  
  
  CONCLUSIONS
  MR angiography may be useful in the long-term follow-up of successfully treated small and medium-sized aneurysms after concurrent primary verification of their occlusion with DSA.
authors.affiliation: Department of Radiology, Tampere University Hospital, Finland.
authors.forename: V J
authors.initials: VJ
authors.lastname: Kähärä
authors.forename: S K
authors.initials: SK
authors.lastname: Seppänen
authors.forename: P S
authors.initials: PS
authors.lastname: Ryymin
authors.forename: P
authors.initials: P
authors.lastname: Mattila
authors.forename: T
authors.initials: T
authors.lastname: Kuurne
authors.forename: E M
authors.initials: EM
authors.lastname: Laasonen
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002343:Carotid Artery, Internal / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000628:therapy*; D018810:Magnetic Resonance Angiography / Q000295:instrumentation*; D008297:Male; D012680:Sensitivity and Specificity; D016896:Treatment Outcome