title: Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.
abstract: Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratorie, Rahway, NJ 07065, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Greenlee
authors.forename: J B
authors.initials: JB
authors.lastname: Laub
authors.forename: J M
authors.initials: JM
authors.lastname: Balkovec
authors.forename: M L
authors.initials: ML
authors.lastname: Hammond
authors.forename: G G
authors.initials: GG
authors.lastname: Hammond
authors.forename: D L
authors.initials: DL
authors.lastname: Pompliano
authors.forename: J H
authors.initials: JH
authors.lastname: Epstein-Toney
mesh_terms: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004952:Esters; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D065093:beta-Lactamase Inhibitors
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D004952:Esters; D013438:Sulfhydryl Compounds; D065093:beta-Lactamase Inhibitors