Growth factors and nutrients in the short bowel syndrome.
Massive intestinal resection often results in long-term dependence on parenteral nutrition (TPN). In an effort to enhance bowel rehabilitation, the amino acid glutamine, growth hormone and a diet optimized to enhance absorption have been administered to >300 patients with the short bowel syndrome. Initially about 60% of the patients were weaned from TPN and an additional 30% had reduced TPN requirements. At long-term follow up (2 years) 40% of the group remained off TPN, 40% had reduced TPN requirements, and 20% had the same requirements. This report addresses issues such as the optimization of diet and provides a care map which should enhance the rehabilitation of patients with the short bowel syndrome.
Wilmore
D W
DW
Laboratories for Surgical Metabolism and Nutrition, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D004750:Enteral Nutrition; D005228:Fatty Acids, Essential / Q000172:deficiency; D005973:Glutamine / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D010289:Parenteral Nutrition, Total; D012778:Short Bowel Syndrome / Q000534:rehabilitation / Q000628:therapy*
D005228:Fatty Acids, Essential; D005973:Glutamine; D019382:Human Growth Hormone