Lignan and phenylpropanoid glycosides from Lancea tibetica and their antitumor activity.
A new lignan glucoside, the first 7,9'-monoepoxyte-trahydrofuran type lignan with the cis-relationship of H-7 and H-8, named tibeticoside (1), as well as ten known compounds have been isolated from the medicinal plant (roots, stems and leaves) Lancea tibetica. The structure of tibeticoside (1) has been elucidated on the basis of chemical and spectral evidence, especially by 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY). In addition, sylvatesmin (6) exhibited effective antitumor activity on B16 cells.
Su
B
B
Department of Chemistry, Lanzhou University, People's Republic of China.
Zhu
Q
Q
Gao
K
K
Yuan
C
C
Jia
Z
Z
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects*; D002681:China; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D008516:Medicine, Chinese Traditional; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves; D018517:Plant Roots; D018547:Plant Stems; D010946:Plants, Medicinal; D020005:Propanols / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D017705:Lignans; D010936:Plant Extracts; D020005:Propanols