title: The birthdates of GABA-immunoreactive amacrine cells in the rat retina.
abstract: The birthdates of GABAergic amacrine cells in the rat retina were investigated by immunocytochemistry using anti-GABA and anti-bromodeoxyuridine (BrdU) antisera. The ratio of co-localization of GABA to BrdU increased gradually from embryonic-day 13 (E13) and showed a peak value on E18 in the central retina and on E20 in the periphery. After birth, until postnatal-day 3 (P3), a few co-localized cells were observed in the inner nuclear layer (INL). However, in the peripheral retina, co-localized cells were observed in the INL and ganglion cell layer until P5. Our results suggest that the birthdates of GABA-immunoreactive cells vary, depending on cell-type and that there is a temporal lag in the GABA-immunoreactive cell production in the peripheral retina relative to the central retina.
authors.affiliation: Department of Anatomy, College of Medicine, The Catholic University of Korea, Banpo-dong, Socho-gu, Seoul 137-701, Korea,
authors.forename: M Y
authors.initials: MY
authors.lastname: Lee
authors.forename: S L
authors.initials: SL
authors.lastname: Shin
authors.forename: S H
authors.initials: SH
authors.lastname: Han
authors.forename: M H
authors.initials: MH
authors.lastname: Chun
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001973:Bromodeoxyuridine / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000166:cytology / Q000196:embryology*; D012165:Retinal Ganglion Cells / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D001973:Bromodeoxyuridine