title: A Small-Molecule Guanidinium Receptor: The Arginine Cork.
abstract: A highly preorganized, artificial receptor for guanidinium cations binds arginine with high affinity in polar solvents, even in water! The X-ray crystal structure of its bis(N-ethylguanidinium) complex shows the formation of hydrogen bonds between the receptor and the guest (see picture). This observation explains the strength of the complex formed with the dipeptide diarginine (K(d)=50 µM in H(2)O).
authors.affiliation: Department of Chemistry, University of Nevada, Reno, NV 89557-0020 (USA).
authors.initials: TW
authors.lastname: Bell
authors.initials: AB
authors.lastname: Khasanov
authors.initials: MG
authors.lastname: Drew
authors.initials: A
authors.lastname: Filikov
authors.initials: TL
authors.lastname: James