title: Injection with methylprednisolone proximal to the carpal tunnel: randomised double blind trial.
abstract: OBJECTIVE
  To assess the effect of a 40 mg methylprednisolone injection proximal to the carpal tunnel in patients with the carpal tunnel syndrome.
  
  
  METHODS
  Randomised double blind placebo controlled trial.
  
  
  METHODS
  Outpatient neurology clinic in a district general hospital.
  
  
  METHODS
  Patients with symptoms of the carpal tunnel syndrome for more than 3 months, confirmed by electrophysiological tests and aged over 18 years.
  
  
  METHODS
  Injection with 10 mg lignocaine (lidocaine) or 10 mg lignocaine and 40 mg methylprednisolone. Non-responders who had received lignocaine received 40 mg methylprednisolone and 10 mg lignocaine and were followed in an open study.
  
  
  METHODS
  Participants were scored as having improved or not improved. Improved was defined as no symptoms or minor symptoms requiring no further treatment.
  
  
  RESULTS
  At 1 month 6 (20%) of 30 patients in the control group had improved compared with 23 (77%) of 30 patients the intervention group (difference 57% (95% confidence interval 36% to 77%)). After 1 year, 2 of 6 improved patients in the control group did not need a second treatment, compared with 15 of 23 improved patients in the intervention group (difference 43% (23% to 63%). Of the 28 non-responders in the control group, 24 (86%) improved after methylprednisolone. Of these 24 patients, 12 needed surgical treatment within one year.
  
  
  CONCLUSIONS
  A single injection with steroids close to the carpal tunnel may result in long term improvement and should be considered before surgical decompression.
authors.affiliation: Department of Neurology, Medical Centre Alkmaar, 1800 AM Alkmaar, Netherlands. J.Dammers@mca.alkmaar.nl
authors.forename: J W
authors.initials: JW
authors.lastname: Dammers
authors.forename: M M
authors.initials: MM
authors.lastname: Veering
authors.forename: M
authors.initials: M
authors.lastname: Vermeulen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone