title: No association of paraoxonase gene polymorphism with atherosclerosis or Alzheimer's disease.
abstract: Both AD and paraoxonase (PON) have been reported to be related to lipids and atherosclerosis, suggesting that the PON gene (PON) is a possible genetic risk factor for AD. We found no association of PON polymorphism with severity of atherosclerosis, densities of AD-type, neuropathologic change, or development of AD in 47 AD and 90 nondemented patients. Our study suggests that PON polymorphism does not play a causal role in the development of atherosclerosis or AD.
authors.affiliation: Department of Neurology, Tokyo Medical and Dental University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sodeyama
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: N
authors.initials: N
authors.lastname: Suematsu
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: E
authors.initials: E
authors.lastname: Otomo
authors.forename: H
authors.initials: H
authors.lastname: Mizusawa
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001161:Arteriosclerosis / Q000235:genetics* / Q000473:pathology; D043303:Aryldialkylphosphatase; D001921:Brain / Q000473:pathology; D004950:Esterases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D004950:Esterases; D043303:Aryldialkylphosphatase