title: Gas chromatographic-mass spectrometric analysis of urinary sugar and sugar alcohols during pregnancy.
abstract: A refined and simplified method has been developed for the simultaneous analysis of urinary sugar and sugar alcohols after urease treatment by using capillary gas chromatography-mass spectrometry (GC-MS). Since carbohydrate metabolism during pregnancy is considered to be diabetogenic, our interest has been concentrated on understanding the mechanism of the metabolic deviation by assessing the glucose excursion and glucose fluxes. The present study suggests that changes of the levels of glucose, sorbitol, fructose, myo-inositol, and 1,5-anhydro-D-glucitol (1,5-AG) may reflect a mild alteration in carbohydrate metabolism that goes undetected by conventional diabetic indicators.
authors.affiliation: Tetsuo Hospital, Nagasaki-ken, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tetsuo
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: I
authors.initials: I
authors.lastname: Matsumoto
mesh_terms: D002241:Carbohydrates / Q000652:urine*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D005951:Glucose Tolerance Test; D006801:Humans; D011247:Pregnancy / Q000652:urine*; D013402:Sugar Alcohols / Q000652:urine*
chemical_list: D002241:Carbohydrates; D013402:Sugar Alcohols