Snake venom alpha-neurotoxins and other 'three-finger' proteins.
The review is mainly devoted to snake venom alpha-neurotoxins which target different muscle-type and neuronal nicotinic acetylcholine receptors. The primary and spatial structures of other snake venom proteins as well as mammalian proteins of the Ly-6 family, which structurally resemble the 'three-finger' snake proteins, are also briefly discussed. The main emphasis is placed on recent data characterizing the alpha-neurotoxin interactions with nicotinic acetylcholine receptors.
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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. vits@ibch.siobc.ras.ru
D000595:Amino Acid Sequence; D003039:Cobra Neurotoxin Proteins / Q000737:chemistry; D020916:Conotoxins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012910:Snake Venoms / Q000737:chemistry*
D003039:Cobra Neurotoxin Proteins; D020916:Conotoxins; D009498:Neurotoxins; D009842:Oligopeptides; D012910:Snake Venoms; C087686:alpha-conotoxin ImI; C025154:alpha-cobratoxin