title: Lomustine (CCNU) for the treatment of resistant lymphoma in dogs.
abstract: Forty-three dogs with lymphoma that had relapsed or had failed to achieve complete remission to previous chemotherapy were treated with lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea [CCNU]) at a dosage of 90-100 mg/m2 body surface area p.o. every 3 weeks. Durable complete or partial responses occurred in 11 dogs for a median of 86 days. The acutely dose-limiting toxicosis was neutropenia 7 days after administration, resulting in a recommended dosage of 90 mg/m2. Cumulative thrombocytopenia occurred in dogs receiving continued CCNU treatment, and a dose interval of 3 weeks may be too short for continued administration of this drug. Toxicoses evident as fever or central nervous system signs or renal damage were uncommon or rare. CCNU is effective in the treatment of relapsed lymphoma.
authors.affiliation: Harrington Oncology Program, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Moore
authors.forename: C A
authors.initials: CA
authors.lastname: London
authors.forename: C A
authors.initials: CA
authors.lastname: Wood
authors.forename: L E
authors.initials: LE
authors.lastname: Williams
authors.forename: S M
authors.initials: SM
authors.lastname: Cotter
authors.forename: D A
authors.initials: DA
authors.lastname: L'Heureux
authors.forename: A E
authors.initials: AE
authors.lastname: Frimberger
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D019008:Drug Resistance, Neoplasm; D005260:Female; D008130:Lomustine / Q000009:adverse effects / Q000627:therapeutic use*; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009503:Neutropenia / Q000139:chemically induced; D012008:Recurrence; D013921:Thrombocytopenia / Q000139:chemically induced; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008130:Lomustine