title: Recurrent cervical carcinoma after primary radical surgery.
abstract: OBJECTIVE
  This study was undertaken to investigate prognostic factors in patients with recurrent cervical carcinoma who had undergone a primary radical hysterectomy and pelvic lymphadenectomy.
  
  
  METHODS
  A retrospective analysis of 177 patients with recurrent cervical carcinoma after radical hysterectomy and pelvic lymphadenectomy for stage IB to II disease at a single institution was performed to evaluate clinicopathologic parameters, time to recurrence, pattern of failure, use of salvage therapy, and survival after recurrence.
  
  
  RESULTS
  The 5-year survival rate from diagnosis of recurrence in this series was 10.1%. Survival after recurrence was significantly decreased in patients with pelvic lymph node metastasis at primary surgery and adenocarcinoma-adenosquamous carcinoma histologic type. Patients with extravaginal recurrences receiving chemoradiation for recurrent cervical carcinoma had significantly better outcomes than those receiving radiation alone. Six patients who had a distant relapse at a sole site had prolonged survival after salvage therapy, which was accomplished by chemoradiation, surgery plus radiotherapy, or surgery alone.
  
  
  CONCLUSIONS
  Our results demonstrate the benefit of adding chemotherapy to radiotherapy in the treatment of recurrent cervical carcinoma. Salvage multimodality treatment should be offered to selected patients who have isolated relapse at a single distant site.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics, Chang Gung Memorial Hospital, Chang Gung University College, Taipei, Taiwan.
authors.forename: C J
authors.initials: CJ
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Lai
authors.forename: H J
authors.initials: HJ
authors.lastname: Huang
authors.forename: J H
authors.initials: JH
authors.lastname: Hong
authors.forename: H H
authors.initials: HH
authors.lastname: Chou
authors.forename: K G
authors.initials: KG
authors.lastname: Huang
authors.forename: J D
authors.initials: JD
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018196:Carcinoma, Adenosquamous / Q000401:mortality / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010388:Pelvis; D011379:Prognosis; D011878:Radiotherapy; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents