title: Disappearance of wheezing during epidural lidocaine anesthesia in a patient with bronchial asthma.
abstract: OBJECTIVE
  Local anesthetics in blood absorbed from the epidural space attenuate bronchial hyperreactivity to chemical stimuli. However, it is not documented whether local anesthetics at clinically relevant concentrations improve active wheezing in patients with bronchial asthma.
  
  
  METHODS
  We managed a 60-year-old man with bronchial asthma and active wheezing under continuous epidural anesthesia using plain lidocaine. The wheezing gradually diminished 20 minutes after the epidural injection of 13 mL 2% lidocaine and completely disappeared over 155 minutes during continuous epidural injection of 2% lidocaine (6 mL/h). The plasma concentrations of lidocaine in arterial blood during the epidural anesthesia ranged from 2.5 to 3.9 microg/mL. Wheezing reappeared 55 minutes after termination of the continuous epidural injection of lidocaine. The plasma concentration of lidocaine at this time was 1.9 microg/mL.
  
  
  CONCLUSIONS
  At clinically relevant concentrations, lidocaine in the blood absorbed from the epidural space may improve bronchospasm in patients with bronchial asthma.
authors.affiliation: Department of Anesthesiology, School of Medicine, Fukuoka University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shono
authors.forename: K
authors.initials: K
authors.lastname: Higa
authors.forename: I
authors.initials: I
authors.lastname: Harasawa
authors.forename: H
authors.initials: H
authors.lastname: Sugano
authors.forename: K
authors.initials: K
authors.lastname: Dan
mesh_terms: D000767:Anesthesia, Epidural; D000779:Anesthetics, Local / Q000097:blood; D000783:Aneurysm / Q000150:complications / Q000601:surgery; D001249:Asthma / Q000150:complications / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000150:complications / Q000503:physiopathology; D005263:Femoral Artery; D006801:Humans; D008012:Lidocaine / Q000097:blood; D008297:Male; D008875:Middle Aged; D012135:Respiratory Sounds / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine