title: Stability of cefepime in peritoneal dialysis solution.
abstract: OBJECTIVE
  To determine the stability of cefepime in peritoneal dialysis solution.
  
  
  METHODS
  Cefepime HCl was added to premade bags of Delflex peritoneal dialysis solution with 1.5% dextrose to produce a cefepime concentration of approximately 100 microg/mL. Peritoneal dialysis solution bags were stored at 4, 25, and 37 degrees C to simulate refrigeration, room temperature, and body temperature, respectively. Samples were drawn at scheduled times up to 336, 168, and 48 hours, respectively, after the addition of cefepime HCl. Cefepime concentrations were measured by HPLC.
  
  
  METHODS
  This study was performed at a university-affiliated tertiary care hospital.
  
  
  METHODS
  If the mean concentration of the samples at a given time and condition was >90% of the initial concentration, cefepime was considered stable at that time and condition.
  
  
  RESULTS
  The mean HPLC results for samples drawn at each time and condition were all >90%.
  
  
  CONCLUSIONS
  Cefepime is stable in peritoneal dialysis solution with dextrose 1.5% for 14 days refrigerated, seven days at room temperature, and 48 hours at 37 degrees C.
authors.affiliation: Department of Pharmacy, University of Virginia Health System, Charlottesville, USA. jcwunc@belsouth.net
authors.forename: J C
authors.initials: JC
authors.lastname: Williamson
authors.forename: D F
authors.initials: DF
authors.lastname: Volles
authors.forename: P L
authors.initials: PL
authors.lastname: Lynch
authors.forename: P D
authors.initials: PD
authors.lastname: Rogers
authors.forename: D M
authors.initials: DM
authors.lastname: Haverstick
mesh_terms: D000077723:Cefepime; D002511:Cephalosporins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015314:Dialysis Solutions / Q000737:chemistry*; D004355:Drug Stability; D010530:Peritoneal Dialysis; D013696:Temperature; D013997:Time Factors
chemical_list: D002511:Cephalosporins; D015314:Dialysis Solutions; D000077723:Cefepime