title: Serum soluble intercellular adhesion molecule 1 and interleukin 8 levels in familial Mediterranean fever.
abstract: OBJECTIVE
  Familial Mediterranean fever (FMF) is a disease of unknown etiology characterized by recurrent attacks of polyserositis (peritonitis, pleuritis, and arthritis) and fever. We measured levels of soluble intercellular adhesion molecule 1 (sICAM-1) and interleukin 8 (IL-8), which are important mediators in leukocyte-endothelial adhesion and leukocyte accumulation in tissues.
  
  
  METHODS
  sICAM-1 and IL-8 levels were studied in 30 patients with FMF during attacks and remission, along with 23 healthy and 26 disease controls. sICAM-1 and IL-8 levels were measured with commercial ELISA systems.
  
  
  RESULTS
  Median levels of sICAM-1 were significantly elevated in patients with FMF during attacks (FMF-a) and remission periods (FMF-r) compared to healthy controls (HC) (FMF-a: 600 ng/ml, FMF-r: 520 ng/ml, HC: 353 ng/ml; FMF-a vs. HC: p<0.0001, FMF-r vs. HC: p = 0.002). IL-8 levels were also significantly elevated in FMF-a compared to HC (37 vs. 25 pg/ml; p = 0.009), but not during remission (26 pg/ml; p = 0.7). A significant correlation was observed between sICAM-1 and IL-8 levels (r = 0.33, p = 0.01). sICAM-1 levels also correlated significantly with erythrocyte sedimentation rate, C-reactive protein, and fibrinogen levels of patients with FMF.
  
  
  CONCLUSIONS
  Increased levels of sICAM-1 and IL-8 in FMF suggest that neutrophils are active with increased adhesion in FMF. Since increased levels of sICAM-1 are also observed during remission, subclinical disease activity and inflammation seem to be present in some patients.
authors.affiliation: Division of Rheumatology, Faculty of Medicine, Marmara University, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Direskeneli
authors.forename: H
authors.initials: H
authors.lastname: Ozdogan
authors.forename: C
authors.initials: C
authors.lastname: Korkmaz
authors.forename: T
authors.initials: T
authors.lastname: Akoglu
authors.forename: H
authors.initials: H
authors.lastname: Yazici
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D010505:Familial Mediterranean Fever / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D016209:Interleukin-8; D018799:Intercellular Adhesion Molecule-1