title: Auxiliary total artificial heart: A compact electromechanical artificial heart working simultaneously with the natural heart.
abstract: Leading international institutions are designing and developing various types of ventricular assist devices (VAD) and total artificial hearts (TAH). Some of the commercially available pulsatile VADs are not readily implantable into the thoracic cavity of smaller size patients because of size limitation. The majority of the TAH dimensions requires the removal of the patients' native heart. A miniaturized artificial heart, the auxiliary total artificial heart (ATAH), is being developed in these authors' laboratories. This device is an electromechanically driven ATAH using a brushless direct current (DC) motor fixed in a center metallic piece. This pusher plate-type ATAH control is based on Frank-Starling's law. The beating frequency is regulated through the change of the left preload, assisting the native heart in obtaining adequate blood flow. With the miniaturization of this pump, the average sized patient can have the surgical implantation procedure in the right thoracic cavity without removing the native heart. The left and right stroke volumes are 35 and 32 ml, respectively. In vitro tests were conducted, and the performance curves demonstrate that the ATAH produces 5 L/min of cardiac output at 180 bpm (10 mmHg of left inlet mean pressure and 100 mm Hg of left outlet mean pressure). Taking into account that this ATAH is working along with the native heart, this output is more than satisfactory for such a device.
authors.affiliation: Department of Bioengineering, Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Andrade
authors.forename: D
authors.initials: D
authors.lastname: Nicolosi
authors.forename: J
authors.initials: J
authors.lastname: Lucchi
authors.forename: J
authors.initials: J
authors.lastname: Biscegli
authors.forename: A C
authors.initials: AC
authors.lastname: Arruda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: J
authors.initials: J
authors.lastname: Mueller
authors.forename: E
authors.initials: E
authors.lastname: Tayama
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D001794:Blood Pressure; D002302:Cardiac Output; D011211:Electric Power Supplies; D004560:Electricity; D006321:Heart / Q000502:physiology; D006339:Heart Rate; D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006801:Humans; D008422:Materials Testing; D008904:Miniaturization; D011474:Prosthesis Design; D013318:Stroke Volume; D016277:Ventricular Function, Left