[Pristinamycin in the outpatient treatment of acute sinusitis in adults].
TWO MAIN GERMS: The risk of severe complications of acute bacterial sinusitis warrants empirical antibiotic therapy targeted against the two main causal agents: S. pneumoniae and H. influenzae.
A double-blind placebo-controlled randomized multicentric study conducted with two treatment arms including 310 patients has demonstrated that pristinamycin, 2 g/d for 8 days, has a clinical efficacy equivalent to cefuroxime axetil, 500 mg/d.


CONCLUSIONS
Pristinamycin is an interesting alternative to beta-lactams for the first intention treatment of purulent acute sinusitis in adults. Its efficacy against penicillin-resistant pneumococci and H. influenzae is a further reason for its use in case of failure after conventional treatments.
Pessey
J J
JJ
D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000553:Ambulatory Care; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012852:Sinusitis / Q000188:drug therapy*; D016896:Treatment Outcome; D014769:Virginiamycin / Q000494:pharmacology / Q000627:therapeutic use*
D010919:Placebos; D014769:Virginiamycin