title: [Purulent complications in the surgical treatment of patients with mouth cancer and their prevention].
abstract: Local purulent complications after surgical operations for mouth cancer were recorded in 49 (61.3 per cent) out of 80 cases and were mainly due to associations of 2 or more pathogens. The analysis of the factors influencing the development of the complications showed that there was no reliable increase in the number of the complications in the patients subjected at the first stage to the treatment with various antitumor agents: 17 (53.1 per cent) events in the group of the patients subjected to radiotherapy in a total focal dose of 40 Gy, 8 (72.7 per cent) events in the group of the patients subjected to radiotherapy in a dose of more than 60 Gy, 13 (59.1 per cent) events in the group of the patients treated with antitumor drugs and 8 (66.7 per cent) events in the group of the patients operated at the first stage of the treatment. The incidence of osteomyelitis was significantly higher in the group of the patients subjected to radiotherapy before the operation: 13 (30.2 per cent) events vs. 2 (5.4 per cent) in the group of the patients not subjected to radiotherapy. With increasing of the radiation dose, the incidence of osteomyelitis as well increased: 8 (25.0 per cent) osteomyelitis events in the group of the patients subjected to radiotherapy in a dose of 40 Gy and 5 (45.5 per cent) events in the group of the patients subjected to radiotherapy in a dose of more than 60 Gy. The method of osteosynthesis of the lower maxilla with titanium miniplates was also of great importance. The use of various schemes for antibiotic prophylaxis of wound infection in such patients was equally efficient.
authors.affiliation: N.N. Blokhin Research Centre of Oncology, Russian Academy of Medical Sciences, Moscow.
authors.forename: M A
authors.initials: MA
authors.lastname: Kropotov
authors.forename: E G
authors.initials: EG
authors.lastname: Matiakin
authors.forename: A V
authors.initials: AV
authors.lastname: Zheltova
authors.forename: N V
authors.initials: NV
authors.lastname: Dmitrieva
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D010019:Osteomyelitis / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*