title: Poststroke depression and its role in rehabilitation of inpatients.
abstract: OBJECTIVE
  To identify the prevalence of poststroke depression (PSD) in a population of patients admitted for rehabilitation of neurologic sequelae of their first stroke, to recognize reliable prognostic factors associated with the occurrence of PSD, and to evaluate the impact of PSD on the results of rehabilitation treatment.
  
  
  METHODS
  In a prospective study of 470 of 508 consecutive patients admitted to a rehabilitation hospital for sequelae of their first stroke, the relation between 23 independent variables and the development of depression was assessed by using a logistic regression analysis (forward stepwise). In addition, the impact of PSD on basal disability and on rehabilitation results was assessed by multiple measures (length of stay, efficiency, effectiveness, and percent of low responders on activities of daily living [ADL] and mobility).
  
  
  RESULTS
  PSD occurred in 129 patients (27.4%). Being female and having more than 8 years of schooling were associated with a higher probability of developing depression (odds ratio [OR] = 1.94, 95% confidence interval [CI] = 1.27-2.96, and OR = 1.61, 95% CI = 1.04-2.48, respectively). No association was found with site or side of cerebral lesion. In a logistic model, depression was a significant independent predictor (OR = 1.99, 95% CI = 1.14-3.46) of low response on ADL in spite of treatment.
  
  
  CONCLUSIONS
  PSD occurs especially in female patients and in patients with a high level of education and, even if treated, may affect rehabilitation results. No association was found between brain lesion location and PSD.
authors.affiliation: I.R.C.C.S. Santa Lucia, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Paolucci
authors.forename: G
authors.initials: G
authors.lastname: Antonucci
authors.forename: L
authors.initials: L
authors.lastname: Pratesi
authors.forename: M
authors.initials: M
authors.lastname: Traballesi
authors.forename: M G
authors.initials: MG
authors.lastname: Grasso
authors.forename: S
authors.initials: S
authors.lastname: Lubich
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000368:Aged; D001925:Brain Damage, Chronic / Q000523:psychology / Q000534:rehabilitation; D002561:Cerebrovascular Disorders / Q000523:psychology / Q000534:rehabilitation*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D010555:Personality Inventory; D011379:Prognosis; D012307:Risk Factors; D012803:Sick Role; D016896:Treatment Outcome