Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder.
In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.
Caberlotto
L
L
Karolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
Hurd
Y L
YL
D000328:Adult; D000368:Aged; D001345:Autoradiography; D001714:Bipolar Disorder / Q000378:metabolism*; D003866:Depressive Disorder / Q000378:metabolism; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000096:biosynthesis*; D017397:Prefrontal Cortex / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D012559:Schizophrenia / Q000378:metabolism; D018709:Statistics, Nonparametric
D009478:Neuropeptide Y; D012333:RNA, Messenger