title: A pilot study of MRI activity before and during interferon beta-1a therapy.
abstract: We compared the number of new gadolinium-enhancing and T2-weighted lesions on six monthly MRI scans in eight patients with relapsing multiple sclerosis before and during treatment with weekly intramuscular interferon beta-1a (Avonex; 30 microg). MRI activity was modestly reduced during treatment (p = 0.016). The treatment effect was also significant after adjusting pretreatment lesion frequency for regression to the mean. Based on this pilot study, Avonex, as approved for treatment of relapsing forms of MS in the United States, reduces new MRI activity.
authors.affiliation: UCSF/Mt. Zion Multiple Sclerosis Center, San Francisco, CA 94115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Waubant
authors.forename: D E
authors.initials: DE
authors.lastname: Goodkin
authors.forename: R
authors.initials: R
authors.lastname: Sloan
authors.forename: P B
authors.initials: PB
authors.lastname: Andersson
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology*; D010865:Pilot Projects
chemical_list: D016899:Interferon-beta; D000068556:Interferon beta-1a