Unbalanced translocation t(1;3)(p12-13;q11) in meningiomas as the unique feature of chordoid differentiation.
Chordoid meningioma is a rare histological subtype of meningiomas. Cytogenetic analysis of three cases revealed the unique feature of an unbalanced translocation der(1)t(1;3)(p12-13;q11) that was ascertained by chromosome microdissection and reverse fluorescence in situ hybridization. As the t(1;3) has not been observed in other subtypes of meningioma, it may represent a specific cytogenetic marker of chordoid meningiomas. It is not yet clear whether a fusion gene or the combined loss of genes from chromosome arms 1p and 3p is the pathogenetically important outcome of the translocation.
Steilen-Gimbel
H
H
Neurosurgical Clinic, Saarland University, Homburg/Saar, Germany.
Niedermayer
I
I
Feiden
W
W
Freiler
A
A
Steudel
W I
WI
Zang
K D
KD
Henn
W
W
D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002817:Chordoma / Q000235:genetics* / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic