Pituitary adenylate cyclase activating polypeptide (PACAP) is present in human and cat gastric glands.
In the present work we have studied the occurrence of pituitary adenylate cyclase activating polypeptide (PACAP) in human and cat stomach mucosa using immunohistochemistry. As seen under a light microscope, there were many large rounded and ovoid cells that were PACAP immunopositive, mainly in the neck of the gastric glands of both species. The immunopositive material was predominant in the perinuclear area. The PACAP immunolabeling was specific because the preincubation of the antiserum with PACAP abolished the immunostaining. In human samples under electron microscope, the PACAP immunoreactive cells have shown the characteristics of parietal cells. In faintly stained cells, the localization of DAB reaction product was associated with the surface of the intracellular canaliculi. Cell labeling could not be observed besides parietal cells.
Vincze
E
E
Department of Gastroenterology of the Central Hospital of the Ministry of the Interior, Budapest, Hungary.
Kántor
O
O
Kiss
A
A
Gonda
G
G
Gombás
P
P
Kiss
J
J
Juhász
M
M
Arimura
A
A
Köves
K
K
D000818:Animals; D002415:Cats; D005753:Gastric Mucosa / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009479:Neuropeptides / Q000378:metabolism*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide
C495401:ADCYAP1 protein, human; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide