title: Role of sugar re-puckering in the transition of A and B forms of DNA in solution. A molecular dynamics study.
abstract: State of the art molecular dynamic simulations show that simple modification of the sugar puckering of 2'deoxyriboses leads to a reversible change between two stable forms of DNA which resemble very closely the canonical A and B duplex forms. Analysis of the A-type and B-type structures reveals interesting, and previously unknown features of these two families of conformations of the DNA.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Facultat de Química, Universitat de Barcelona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Soliva
authors.forename: F J
authors.initials: FJ
authors.lastname: Luque
authors.forename: C
authors.initials: C
authors.lastname: Alhambra
authors.forename: M
authors.initials: M
authors.lastname: Orozco
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012996:Solutions
chemical_list: D002241:Carbohydrates; D012996:Solutions; D004247:DNA