title: Sensitivity studies of beam directionality, beam size, and neutron spectrum for a fission converter-based epithermal neutron beam for boron neutron capture therapy.
abstract: Sensitivity studies of epithermal neutron beam performance in boron neutron capture therapy are presented for realistic neutron beams with varying filter/moderator and collimator/delimiter designs to examine the relative importance of neutron beam spectrum, directionality, and size. Figures of merit for in-air and in-phantom beam performance are calculated via the Monte Carlo technique for different well-optimized designs of a fission converter-based epithermal neutron beam with head phantoms as the irradiation target. It is shown that increasing J/phi, a measure of beam directionality, does not always lead to corresponding monotonic improvements in beam performance. Due to the relatively low significance, for most configurations, of its effect on in-phantom performance and the large intensity losses required to produce beams with very high J/phi, beam directionality should not be considered an important figure of merit in epithermal neutron beam design except in terms of its consequences on patient positioning and collateral dose. Hardening the epithermal beam spectrum, while maintaining the specific fast neutron dose well below the inherent hydrogen capture dose, improves beam penetration and advantage depth and, as a desirable by-product, significantly increases beam intensity. Beam figures of merit are shown to be strongly dependent on beam size relative to target size. Beam designs with J/phi approximately 0.65-0.7, specific fast neutron doses of 2-2.6x10(-13) Gy cm2/n and beam sizes equal to or larger than the size of the head target produced the deepest useful penetration, highest therapeutic ratios, and highest intensities.
authors.affiliation: Nuclear Reactor Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: W S
authors.initials: WS
authors.lastname: Kiger
authors.forename: O K
authors.initials: OK
authors.lastname: Harling
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D005214:Fast Neutrons / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011880:Radiotherapy Planning, Computer-Assisted; D012680:Sensitivity and Specificity