Fatal fulminant hepatic failure due to cyproterone acetate.
Cyproterone acetate is a normally well-tolerated drug that is used widely for the treatment of prostatic carcinoma. Liver toxicity due to its use is not well known. We describe two cases of fatal fulminant hepatitis related to the use of cyproterone acetate.
Friedman
G
G
Department of Pathology, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Lamoureux
E
E
Sherker
A H
AH
D000368:Aged; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D017373:Cyproterone Acetate / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology
D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D017373:Cyproterone Acetate