Encephalopathy in scleromyxedema.
The authors monitored CSF findings for over 5 months in a patient with a fatal case of scleromyxedema and two episodes of encephalopathy. During both encephalopathy episodes, CSF protein and immunoglobulin G (IgG) levels were elevated without an increased IgG index or IgG synthesis rate. A CSF-dominant increase in the concentration of interleukin-6 (IL-6) also was noted during encephalopathy. These findings suggest a disruption of the blood-brain barrier and that IL-6 may play some role in mediating the encephalopathy. OFF
Johkura
K
K
Department of Neurology, Urafune Hospital, Yokohama City University, Yokohama, Japan.
Susuki
K
K
Hasegawa
O
O
Kuroiwa
Y
Y
Komatsumoto
S
S
D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000209:etiology / Q000473:pathology; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017520:Mucinoses / Q000150:complications*; D009230:Myxedema / Q000150:complications*