Polyneuropathy as initial manifestation of systemic sclerosis (scleroderma).
We report the first case of a young female patient who developed a sensory-motor polyneuropathy, without any skin or internal involvement characteristic of SSc, but with a serological positivity of antitopoisomerase I antibodies. After 4 years she developed a rapid skin tightening with lung involvement, in a full blown picture of the diffuse subset of SSc. The case suggests that the peripheral nervous system deserves more attention, in particular in the earliest phase of SSc.
Knupp-Oliveira
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Department of Pediatrics, Universidade Federal do Rio de Janeiro, Brasil.
Cerinic
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MM
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D004264:DNA Topoisomerases, Type I / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000503:physiopathology
D001323:Autoantibodies; D004264:DNA Topoisomerases, Type I