Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co gamma-rays in Wistar rats.
Radioprotective effects of sodium tungstate (ST) on 60Co gamma-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined. A long-term administration of ST (less than 150 mg/kg body weight/day) for 60-300 days had no significant effects on body and organs weights and survival days. The LD50/60 in 20 weeks old rats was 220 mg/kg body weight/day. Daily administration of 38, 75 or 150 mg from 7 days before and after irradiation to 60 days significantly mitigated the decrease in hematocrit values, especially at 23 days after irradiation (P < 0.05). The highest mitigation rate of the decrease in hematocrit value was observed in rats administered at a dose of 38 mg ST/day. Simultaneously, a dose of 38 mg ST/day inhibited lethal effect of 60Co gamma-rays significantly. The dose-reduction factor for survival of 38 mg ST administered rats was 1.14.
Sato
K
K
Department of Environmental Sciences, Faculty of Science, Ibaraki University, Mito, Japan.
Ichimasa
M
M
Miyahara
K
K
Shiomi
M
M
Nishimura
Y
Y
Ichimasa
Y
Y
D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D005720:Gamma Rays / Q000009:adverse effects; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011836:Radiation Tolerance / Q000187:drug effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017973:Tungsten Compounds / Q000494:pharmacology*
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D017973:Tungsten Compounds; C025399:sodium tungstate(VI)