Applications of the case/multicase SAR method to environmental and public health situations.
The availability of validated and characterized SAR models of toxicological phenomena provides a method to apply SAR technology to a variety of environmental, public health and industrial situations. These include (i) the prioritization of environmental pollutants for control and/or regulation, (ii) the design of multi-action optimized therapeutics from which the potential for unwanted side-effects have been engineered out, (iii) the development of SAR-based computer-driven screening procedure to identify candidate therapeutics based upon combinatorial chemistry or compilations of molecular structures, (iv) the generation of toxicological profiles to be used in the selection of benign chemicals in the early stages of product development.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA.
Cunningham
A R
AR
Zhang
Y P
YP
Klopman
G
G
D000393:Air Pollutants / Q000633:toxicity; D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity*; D004967:Estrogens / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D011634:Public Health / Q000379:methods*; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000379:methods*
D000393:Air Pollutants; D004785:Environmental Pollutants; D004967:Estrogens