title: Autosome search for schizophrenia susceptibility genes in multiply affected families.
abstract: We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3. 6. Nevertheless three regions were suggestive of linkage.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK.
authors.forename: M I
authors.initials: MI
authors.lastname: Rees
authors.forename: I
authors.initials: I
authors.lastname: Fenton
authors.forename: N M
authors.initials: NM
authors.lastname: Williams
authors.forename: P
authors.initials: P
authors.lastname: Holmans
authors.forename: N
authors.initials: N
authors.lastname: Norton
authors.forename: A
authors.initials: A
authors.lastname: Cardno
authors.forename: P
authors.initials: P
authors.lastname: Asherson
authors.forename: G
authors.initials: G
authors.lastname: Spurlock
authors.forename: E
authors.initials: E
authors.lastname: Roberts
authors.forename: E
authors.initials: E
authors.lastname: Parfitt
authors.forename: R
authors.initials: R
authors.lastname: Mant
authors.forename: H
authors.initials: H
authors.lastname: Vallada
authors.forename: E
authors.initials: E
authors.lastname: Dawson
authors.forename: M W
authors.initials: MW
authors.lastname: Li
authors.forename: D A
authors.initials: DA
authors.lastname: Collier
authors.forename: J F
authors.initials: JF
authors.lastname: Powell
authors.forename: S
authors.initials: S
authors.lastname: Nanko
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D002874:Chromosome Mapping / Q000379:methods; D004247:DNA / Q000097:blood; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D004247:DNA