Quinolinic acid inhibits DOI-induced head shakes in mice.
Quinolinic acid, a metabolite of tryptophan in the kynurenine pathway, inhibited the 5-HT(2A/2C) direct agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino propane hydrochloride (DOI) induced head shakes in mice in a dose-dependent manner. This effect was observed 10 min after intracerebroventricular (i.c.v.) administration of 0.0625-1 microg/mouse. 3-Hydroxyanthranilic acid, which is the immediate stable precursor of quinolinic acid in the kynurenine pathway, showed a similar effect 60-120 min after subcutaneous (s.c.) administration, without showing any effect 10 min after i.c.v. administration or 20-40 min after s.c. administration. These observations suggest that quinolinic acid can alter central effects mediated via 5-HT2A receptors.
Kariyawasam
S H
SH
Pharmacology Research, Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
Handley
S L
SL
D015095:3-Hydroxyanthranilic Acid / Q000494:pharmacology; D000662:Amphetamines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019416:Head Movements / Q000187:drug effects*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D007737:Kynurenine / Q000378:metabolism; D008297:Male; D051379:Mice; D017378:Quinolinic Acid / Q000494:pharmacology*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D000662:Amphetamines; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; D015095:3-Hydroxyanthranilic Acid; D007737:Kynurenine; D017378:Quinolinic Acid; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine