title: Chlamydospore formation in Candida albicans requires the Efg1p morphogenetic regulator.
abstract: Chlamydospore formation of the fungal pathogen Candida albicans was found to depend on the Efg1 protein, which regulates the yeast-hyphal transition. Isogenic mutants lacking EFG1 or encoding T206A and T206E variants did not differentiate chlamydospores, while cek1, cph1, or tpk2 mutations had no effect. Furthermore, filamentation of efg1 cph1 double mutants in microaerophilic conditions suggests a novel Efg1p/Cph1p-independent filamentation pathway in C. albicans.
authors.affiliation: Institut für Mikrobiologie, Heinrich-Heine-Universität, D-40225 Düsseldorf, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Sonneborn
authors.forename: D P
authors.initials: DP
authors.lastname: Bockmühl
authors.forename: J F
authors.initials: JF
authors.lastname: Ernst
mesh_terms: D002176:Candida albicans / Q000502:physiology*; D004268:DNA-Binding Proteins; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D013172:Spores, Fungal / Q000502:physiology; D013329:Structure-Activity Relationship; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; C121438:EFG1 protein, Candida albicans; D005656:Fungal Proteins; D014157:Transcription Factors