title: Recombinant baculoviruses as expression vectors for insect and mammalian cells.
abstract: Baculovirus expression vectors are widely used for expressing heterologous proteins in cultured insect cells. Recent advances include further development of the system for production of multi-subunit protein complexes, co-expression of protein-modifying enzymes to improve heterologous protein production, and additional applications of baculovirus display technology. The application of modified baculovirus vectors for gene expression in mammalian cells continues to expand.
authors.affiliation: Molecular Sciences Department Glaxo Wellcome 5 Moore Drive, Research Triangle Park, NC 27709, USA. tak4306@glaxowellcome.com
authors.forename: T A
authors.initials: TA
authors.lastname: Kost
authors.forename: J P
authors.initials: JP
authors.lastname: Condreay
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics / Q000378:metabolism; D016367:Baculoviridae / Q000235:genetics*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D007313:Insecta / Q000821:virology*; D008322:Mammals / Q000821:virology*; D011994:Recombinant Proteins / Q000235:genetics* / Q000378:metabolism; D014614:Vaccines, Synthetic / Q000235:genetics
chemical_list: D000941:Antigens; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic