title: Studies of infectivity and pathogenicity of an isolate of Trypanosoma evansi in Yankasa sheep.
abstract: The course of experimental infection and pathogenicity of an isolate of Trypanosoma evansi were investigated using eight infected and six uninfected control Yankasa sheep. The sheep were each infected intravenously via the jugular vein with approximately 2.0 x 10(6) T. evansi parasites. The effects of the parasite on body temperature, packed cell volume (PCV), haemoglobin, erythrocytes, total protein, were monitored three times a week for approximately 9 weeks. Body weights were determined once every week for the duration of the experiment. The results showed that all the infected sheep were positive for the parasite. The prepatent period varied between 3 and 6 days. T. evansi produced parasitaemic waves at an average of 8.3 days interval. Two distinct forms of the disease were produced namely, acute (4-14 days postinfection), and chronic (43-59 days postinfection). Anaemia was a distinct feature of the disease. While the mean rectal temperatures were significantly elevated (P < 0.05), the mean values of the haematological parameters of the infected sheep dropped significantly (P < 0.05) compared to the preinfection levels. Observed clinical signs included pale mucous membrane, epiphora, loss of appetite, emaciation, dullness and rough hair coat together with fluctuating pyrexia which in most cases coincided with rise in parasitaemia. It is suggested that the isolate of T. evansi is pathogenic for Yankasa sheep.
authors.affiliation: Department of Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: P A
authors.initials: PA
authors.lastname: Audu
authors.forename: K A
authors.initials: KA
authors.lastname: Esievo
authors.forename: G
authors.initials: G
authors.lastname: Mohammed
authors.forename: O J
authors.initials: OJ
authors.lastname: Ajanusi
mesh_terms: D000818:Animals; D001831:Body Temperature; D001835:Body Weight; D002162:Camelus; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009549:Nigeria; D018512:Parasitemia / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology*; D013154:Spleen / Q000473:pathology; D014345:Trypanosoma / Q000472:pathogenicity*; D014352:Trypanosomiasis / Q000469:parasitology / Q000662:veterinary*
chemical_list: D006454:Hemoglobins