title: Technetium-99m sulfur colloid scanning and correlative magnetic resonance imaging in patients with hairy cell leukemia and hypocellular bone marrow biopsies after 2-chlorodeoxyadenosine.
abstract: It has been observed that some patients in complete remission (CR) after 2-chlorodeoxyadenosine (2-CdA) for hairy cell leukemia (HCL) have hypocellular bone marrow biopsies despite normal peripheral blood cell counts. This discrepancy between bone marrow cellularity and peripheral blood cell counts suggests the possibility of abnormal sites of hematopoiesis. To determine sites of hematopoiesis, 11 radionuclide scans using technetium-99m (99mTc) sulfur colloid were performed in eight patients. Although no single, pattern was observed on the 99mTc sulfur colloid scans, two of the eight patients, both with virtually aplastic marrows, had multiple areas of increased uptake in the distal appendicular skeleton, suggesting abnormal sites of hematopoiesis. The same two patients had magnetic resonance imaging (MRI), which confirmed the abnormal sites of hematopoiesis.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Robert H. Lurie Cancer Center of Northwestern University Chicago, Illinois 60611, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Siegel
authors.forename: D
authors.initials: D
authors.lastname: Hakimian
authors.forename: W
authors.initials: W
authors.lastname: Spies
authors.forename: E R
authors.initials: ER
authors.lastname: Wollins
authors.forename: L C
authors.initials: LC
authors.lastname: Peterson
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: M S
authors.initials: MS
authors.lastname: Tallman
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D002452:Cell Count / Q000187:drug effects; D017338:Cladribine / Q000627:therapeutic use*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012074:Remission Induction / Q000379:methods; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D017338:Cladribine; D013671:Technetium Tc 99m Sulfur Colloid