Total synthesis of (+/-)-homoepibatidine.
Total synthesis of (+/-)-homoepibatidine (2), which contains the 8-azabicyclo[3.2.1] octane ring system, was achieved by using palladium-catalyzed Heck-type coupling reaction from 3.
Kim
Y H
YH
College of Pharmacy, SungKyunKwan University, Suwon, Korea.
Won
D Y
DY
Oh
C Y
CY
Lee
K Y
KY
Jeong
J H
JH
Jung
Y H
YH
Ham
W H
WH
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010165:Palladium; D011725:Pyridines / Q000138:chemical synthesis*
D018712:Analgesics, Non-Narcotic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007202:Indicators and Reagents; D011725:Pyridines; D010165:Palladium; C082748:epibatidine