Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
This study investigates the antinociceptive and antihyperalgesic action caused by i.p., i.t. or i.c.v. injections of amiloride when assessed against formalin, capsaicin-induced licking, acetic acid-induced writhing and glutamate-induced hyperalgesia in mice. The systemic, spinal and supraspinal administration of amiloride causes dose-related antinociception when assessed against acetic acid-induced writhing, formalin and capsaicin-induced licking. In addition, amiloride administered by the same routes produced graded inhibition of glutamate-induced hyperalgesia in mice. Together, these results suggest, that amiloride or its derivatives may constitute a strategy for the development of new antinociceptive drugs.
Ferreira
J
J
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis-SC, Brazil.
Santos
A R
AR
Calixto
J B
JB
D019342:Acetic Acid / Q000494:pharmacology; D000584:Amiloride / Q000008:administration & dosage*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology; D004195:Disease Models, Animal; D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005557:Formaldehyde / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects
D004232:Diuretics; D005557:Formaldehyde; D018698:Glutamic Acid; D000584:Amiloride; D019342:Acetic Acid; D002211:Capsaicin