Safety and effect on anti-Chlamydia pneumoniae antibody titres of a 1 month course of daily azithromycin in adults with coronary artery disease.
A pilot study of azithromycin treatment following percutaneous coronary revascularization procedures was performed to assess safety and the effect of azithromycin treatment on anti-Chlamydia pneumoniae antibody titres. Patients were randomized to a 1 month course of azithromycin (total dose of 8.0 g) or placebo. Safety and compliance were assessed at 2 and 4 weeks and serological testing was performed on samples obtained at enrolment and at 6 months post-enrolment. Azithromycin was well tolerated at this dose. No effect of treatment on antibody titres was demonstrated. These results support further clinical trials to assess the effect of azithromycin treatment on cardiovascular disease outcomes.
Jackson
L A
LA
Department of Epidemiology, University of Washington, Seattle 98195-7236, USA. lajack@u.washington.edu
Stewart
D K
DK
Wang
S P
SP
Cooke
D B
DB
Cantrell
T
T
Grayston
J T
JT
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000908:Antibodies, Fungal / Q000032:analysis; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D016993:Chlamydophila pneumoniae / Q000187:drug effects / Q000276:immunology*; D003327:Coronary Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000908:Antibodies, Fungal; D017963:Azithromycin