CD30 positive (non-anaplastic) peripheral T-cell lymphoma of the thyroid gland.
Primary non-Hodgkin's lymphoma of the thyroid gland are infrequent tumors. They almost exclusively derive from B cells of mucosa-associated lymphatic tissue and only a very small minority of them is represented by T cell lymphomas. CD30 molecule, other than in Hodgkin's and Redd-Sternberg' cells, is strictly associated with anaplastic large cell lymphoma and ALK lymphomas, the latter being identified by the monoclonal antibody ALK1. We report a case of CD30-positive non-anaplastic (ALK1-negative) peripheral T cell lymphoma of the thyroid gland and speculate on aspects concerning diagnosis and the morphologic and immunohistochemical findings.
Forconi
F
F
Cattedra e Divisione di Ematologia, Ospedale Sclavo, via Tufi 1, 53100 Siena, Italy. forconif@unisi.it
Bocchia
M
M
Marconcini
S
S
Bigazzi
C
C
Milani
M
M
Fraternali-Orcioni
G
G
Lauria
F
F
D000328:Adult; D048429:Cell Size; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000032:analysis*; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000276:immunology*
D017730:Ki-1 Antigen