title: Preoperative radiotherapy for rectal cancer: implications for surgeons, pathologists and radiologists.
abstract: BACKGROUND
  Over 10,000 new cases of rectal cancer are reported in the UK each year and adjuvant treatments, such as preoperative radiotherapy, are now being used almost routinely.
  
  
  METHODS
  A literature review was performed on the Medline database for English language publications on preoperative radiotherapy and rectal cancer. The radioresponsiveness of rectal cancer, tumour downstaging, radiological staging of irradiated rectal cancer, effects of radiotherapy on anastomotic integrity, anorectal and genitourinary function, the role of preoperative radiotherapy in local excision of rectal cancer, and the histological changes peculiar to radiotherapy were evaluated.
  
  
  CONCLUSIONS
  Following preoperative radiotherapy, rectal cancer may be downstaged or, occasionally, eradicated histologically. Rectal cancer can now be staged accurately before operation, but this is significantly less reliable following irradiation. The pathological specimen must be examined thoroughly before a tumour can be reported to have been eradicated, especially as unique histological changes are produced by radiotherapy. There is no evidence to suggest that preoperative radiotherapy adversely affects anastomotic integrity. It appears that preoperative radiotherapy has some adverse affects on long-term anorectal dysfunction, but this must not distract from its main objectives in rectal cancer, namely reduced local recurrence rates and improved overall survival.
authors.affiliation: Department of Colorectal Surgery, John radcliffe Hospital, Oxford, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Wheeler
authors.forename: B F
authors.initials: BF
authors.lastname: Warren
authors.forename: A C
authors.initials: AC
authors.lastname: Jones
authors.forename: N J
authors.initials: NJ
authors.lastname: Mortensen
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011300:Preoperative Care / Q000379:methods; D011879:Radiotherapy Dosage; D016896:Treatment Outcome