title: The biotransformation of ent-kaur-16-en-19-oic acid by Rhizopus stolonifer.
abstract: Microbial transformation of ent-kaur-16-en-19-oic acid was carried out with R. stolonifer. After seven days of incubation, two metabolites, ent-7 alpha-hydroxy-kaur-16-en-19-oic acid and ent-12 beta-hydroxy-kaur-9(11),16-dien-19-oic acid, were isolated as a result of hydroxylation and hydroxylation/dehydrogenation, respectively. Incubation for 15 days also afforded ent-16 beta,17-dihydroxy-kauran-19-oic acid. The metabolites were identified by spectroscopic methods.
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: E A
authors.initials: EA
authors.lastname: Silva
authors.forename: J A
authors.initials: JA
authors.lastname: Takahashi
authors.forename: M A
authors.initials: MA
authors.lastname: Boaventura
authors.forename: A B
authors.initials: AB
authors.lastname: Oliveira
mesh_terms: D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000493:pharmacokinetics; D015394:Molecular Structure; D012233:Rhizopus / Q000378:metabolism*; D013057:Spectrum Analysis
chemical_list: D004224:Diterpenes; C014341:argyrophilic acid