[Role of nuclear matrix proteins in the formation of heterochromatin].
Heterochromatin consists mainly of satellite DNAs (stDNA), the most rapidly evolving type of DNA sequences of the eucaryotic genome. On the other hand, stDNA is involved in the formation of the functionally conserved centromere structure. Centromeres and pericentromeric stDNA, are known to be in association with nuclear matrix or chromosome scaffold at all stages of the cell cycle. Several lines of evidence show that attachment of stDNA to the nuclear matrix is specific. The first defined parts of the genes found in association with nuclear matrix/scaffold, MAR/SAR, possess some common features with the stDNA. A number of different mechanisms have previously been implicated in heterochromatin formation and centromere conservation. The role of nuclear matrix proteins, which are able to recognize common structural features of MAR/SAR and stDNA, in constitutive heterochromatin organization is discussed in the current review.
Lobov
I B
IB
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Podgornaia
O I
OI
D034961:Antigens, Nuclear; D001483:Base Sequence; D002503:Centromere; D004276:DNA, Satellite / Q000737:chemistry / Q000378:metabolism; D006570:Heterochromatin / Q000378:metabolism*; D009687:Nuclear Proteins / Q000502:physiology*; D009690:Nucleic Acid Conformation
D034961:Antigens, Nuclear; D004276:DNA, Satellite; D006570:Heterochromatin; D009687:Nuclear Proteins