Multifocal polyradiculoneuropathy and carcinoma of the thymus.
We studied a patient with polyradiculoneuropathy with anaplastic carcinoma of the thymus. Motor manifestations dominated. Postmortem examinations indicated that the primary changes were in the spinal nerve roots, peripheral nerves and, possibly, the spinal anterior horn cells. The posterior funiculi and posterior root ganglia were also affected, implying multifocal and multiphasic degeneration. This unusual polyradiculoneuropathy is a form of carcinomatous neuropathy.
Ohtake
T
T
Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, Japan. ohtaket@tmnh.fuchu.tokyo.jp
Nishimura
M
M
Oda
M
M
D000368:Aged; D000870:Anterior Horn Cells / Q000473:pathology; D002277:Carcinoma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D005727:Ganglia, Spinal / Q000473:pathology; D006801:Humans; D010525:Peripheral Nerves / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000473:pathology / Q000503:physiopathology