title: Spermatogenic ability is different among males in different Y chromosome lineage.
abstract: It is a controversial question whether sperm concentrations in humans are changing. Several researchers have reported on environmental factors affecting sperm quality, but the influence of genetic factors is still not fully understood. In this study, we examined the relationship between Y chromosome haplotypes and sperm concentration in fertile males. In addition, we determined the haplotypes of azoospermic patients. The results show that the mean sperm concentration correlates with Y chromosome type. Moreover, the occurrence of azoospermia is related to one particular Y chromosome lineage. Thus, males with a certain haplotype are at a disadvantage for fathering children. The difference of spermatogenic ability among men is important not only in pursuing male competition as in the past but also as relates to the future of modern human males.
authors.affiliation: Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroki
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Yoshiike
authors.forename: S
authors.initials: S
authors.lastname: Nozawa
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: A A
authors.initials: AA
authors.lastname: Ewis
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Toda
authors.forename: K
authors.initials: K
authors.lastname: Tokunaga
authors.forename: S E
authors.initials: SE
authors.lastname: Kotliarova
authors.forename: N
authors.initials: N
authors.lastname: Kondoh
authors.forename: E
authors.initials: E
authors.lastname: Koh
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: T
authors.initials: T
authors.lastname: Shinka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahori
mesh_terms: D005298:Fertility / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018807:Polymorphism, Single-Stranded Conformational; D013076:Sperm Count; D013091:Spermatogenesis / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics*