Peripheral nerve binding patterns of anti-sulphatide antibodies in HIV-infected individuals.
HIV-positive plasma samples from patients with and without neuropathy and with high titre anti-GalS antibodies showed strong binding to the myelin membrane of both fixed and unfixed human sciatic nerve specimens. This staining pattern was also seen with a plasma sample from a patient with IgM paraproteinaemic inflammatory demyelinating neuropathy with anti-GalS IgM antibody. Teased nerve fibres incubated with these anti-GalS antibodies from both HIV and non-HIV plasma samples showed immunofluorescence at the paranodal regions and Schmidt-Lanterman incisures. These data support a potential role for these antibodies in the aetiology of HIV-associated immune mediated neuropathies.
Petratos
S
S
Department of Anatomical Pathology, Royal Melbourne Hospital, Parkville, Australia.
Turnbull
V J
VJ
Papadopoulos
R
R
Ayers
M
M
Gonzales
M F
MF
D003711:Demyelinating Diseases / Q000209:etiology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006017:Glycolipids / Q000276:immunology; D015483:HIV Antibodies / Q000378:metabolism*; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016612:Paraffin Embedding; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D012584:Sciatic Nerve / Q000378:metabolism / Q000473:pathology; D013433:Sulfoglycosphingolipids / Q000276:immunology*
D006017:Glycolipids; D015483:HIV Antibodies; D013433:Sulfoglycosphingolipids