Craniotomy for tumor treatment in an intraoperative magnetic resonance imaging unit.
OBJECTIVE
The complex three-dimensional anatomic features of the brain and its vulnerability to surgical intervention make the surgical treatment of intracranial tumors challenging. We evaluated the surgical treatment of supratentorial tumors using intraoperative magnetic resonance imaging (MRI), which provides real-time guidance, allows localization of intracranial tumors and their margins, and facilitates continuous assessment of surgical progress.


METHODS
Sixty patients underwent craniotomies for tumor treatment in the General Electric intraoperative MRI unit at the Brigham and Women's Hospital (Boston, MA) during a 1-year period. The patients selected were those with intracranial tumors that were considered difficult to resect because of their locations or previous incomplete operations. Twenty-nine low-grade and 19 high-grade gliomas, 8 metastatic lesions, 2 meningiomas, 1 pineoblastoma, and 1 astroblastoma were resected.


RESULTS
Tumors were accurately localized and targeted, and the extent of resection, as well as any intraoperative complications, could be immediately assessed during surgery. Marked brain shifting occurred during the procedures, and repeated intraoperative imaging allowed surgical accommodation for this shifting. In more than one-third of the cases, intraoperative imaging showed residual tumor when resection appeared complete on the basis of surgical observation alone.


CONCLUSIONS
Intraoperative MRI is a revolutionary tool for the surgical treatment of brain tumors, providing observation of the procedure as it is being performed. With intraoperative MRI, tumor resection is safer, the extent of resection can be directly evaluated, and intraoperative complications can be noted if they occur. Outcomes after resection depend on minimizing injury to normal brain tissue and achieving maximal tumor resection. The use of intraoperative MRI directly affects these factors.
Black
P M
PM
Division of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Alexander
E
E
Martin
C
C
Moriarty
T
T
Nabavi
A
A
Wong
T Z
TZ
Schwartz
R B
RB
Jolesz
F
F
D000328:Adult; D000368:Aged; D001921:Brain / Q000033:anatomy & histology; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery*; D003399:Craniotomy; D005260:Female; D005910:Glioma / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000601:surgery; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D018302:Neoplasms, Neuroepithelial / Q000601:surgery; D010870:Pineal Gland / Q000601:surgery; D010871:Pinealoma / Q000601:surgery; D012189:Retrospective Studies; D015173:Supratentorial Neoplasms / Q000473:pathology / Q000556:secondary / Q000601:surgery*