title: Kin protein expression: laminar specificity during rat cerebral cortex development.
abstract: Kin is a mammalian nuclear protein involved in DNA recombination-repair and the regulation of gene expression. The present study explored the expression of the Kin nuclear protein during postnatal development of the rat cerebral cortex, using immunocytochemistry with anti-RecA antibodies. The immunostaining of the Kin protein preferentially occurs within layers IV-V and VIb of the cortex in early postnatal developing brain, whereas in the adult rat this expression is observed unequivocally in all cortical layers. 35S-isotopic in situ hybridization for Kin-17 mRNA confirmed this Kin protein expression pattern and demonstrated its transcription in cortical neurons. This gradual age-related expression during development may have functional implications in the maturation processes of the cortex.
authors.affiliation: INSERM U 480, Neurobiologie des etats de sommeils et déveil, Université Claude Bernard, Lyon, France. ros@sommeil.univ-lyon1.fr
authors.forename: I
authors.initials: I
authors.lastname: Ros
authors.forename: J
authors.initials: J
authors.lastname: Angulo
authors.forename: S
authors.initials: S
authors.lastname: Araneda
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism*; D004268:DNA-Binding Proteins; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009687:Nuclear Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013379:Substrate Specificity; D014018:Tissue Distribution
chemical_list: D004268:DNA-Binding Proteins; C489488:Kin protein, rat; D009687:Nuclear Proteins; D012333:RNA, Messenger