Energy metabolism during anaerobic exercise in children with cystic fibrosis and asthma.
OBJECTIVE
The nature of a child's daily physical activity requires both aerobic and anaerobic energy metabolism. Aerobic exercise becomes compromised with advancing airway obstruction in children with cystic fibrosis (CF) and asthma (AS). Whether children with CF will have altered metabolic responses to supramaximal exercise when compared with asthmatics or healthy controls is still undetermined.


METHODS
Twenty-five children with CF, 22 with AS, and 23 healthy controls (CN) performed an incremental graded aerobic and Wingate anaerobic test (WAnT) on a cycle ergometer. Analysis of gas exchange and ventilatory data was collected and averaged every 5 s to estimate ventilatory kinetics and energy system contributions during both tests.


RESULTS
The CF and AS groups had mild lower airway obstruction (FEF25-75% < 80%) as compared with the CN. All three groups demonstrated similar anaerobic (mean and peak power during the WAnT) and aerobic exercise performance (peak oxygen consumption). In contrast to the AS or CN groups, children with CF used a lower percentage of their peak VO2 and V(E) during each phase of the WAnT, suggesting a preferential use of ATP/phosphocreatine and glycolytic energy stores compared with aerobic pathways. Greater reliance on anaerobic pathways during the WAnT in children with CF could be due to the physiologic sequelae underlying chronic obstructive lung disease.


CONCLUSIONS
Oxygen uptake kinetics appeared similar for all three groups. Although the energy needed to perform the WAnT can be met by subjects with CF, abnormalities in energy metabolism may exist for this group during exercise.
Boas
S R
SR
Department of Pediatrics, Children's Memorial Hospital, Chiacago, IL 60614, USA.
Danduran
M J
MJ
McColley
S A
SA
D000293:Adolescent; D015308:Anaerobic Threshold; D000704:Analysis of Variance; D000886:Anthropometry; D001249:Asthma / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D003550:Cystic Fibrosis / Q000503:physiopathology*; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012044:Regression Analysis; D014797:Vital Capacity