Calcium as a versatile second messenger in the control of gene expression.
The elevation of intracellular calcium is a major effector of stimulus-induced physiological change in a variety of cell types. Such change is invariably complex and frequently involves the activation of gene expression. Calcium signals are often able to activate different subsets of genes within the same cell, the basis for which has been unclear. Recent studies have revealed that a number of differing properties of the calcium signal are responsible for distinct cellular responses.
Hardingham
G E
GE
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, England. geh@mrc-lmb.cam.ac.uk
Bading
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H
D000818:Animals; D002118:Calcium / Q000502:physiology*; D020013:Calcium Signaling; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D020218:Response Elements; D015290:Second Messenger Systems / Q000502:physiology*
D017362:Cyclic AMP Response Element-Binding Protein; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium