title: Genetic polymorphisms at the tumour necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis.
abstract: Many studies have previously confirmed high TNFalpha (tumor necrosis factor-alpha) production in sarcoidosis, and have shown that TNFalpha plays an important role in granuloma formation. We investigated TNFA and TNFB (lymphotoxin-alpha) gene polymorphisms in 26 cardiac sarcoidosis patients of Japanese origin. These studies revealed a significant increase in the more uncommon TNFA2 allele in the patient group, suggesting that the TNFA gene controls the genetic susceptibility to cardiac sarcoidosis.
authors.affiliation: Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Kanagawa Medicine, Isehara Kanagawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takashige
authors.forename: T K
authors.initials: TK
authors.lastname: Naruse
authors.forename: A
authors.initials: A
authors.lastname: Matsumori
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: S
authors.initials: S
authors.lastname: Hiramitsu
authors.forename: S
authors.initials: S
authors.lastname: Sasayama
authors.forename: H
authors.initials: H
authors.lastname: Inoko
mesh_terms: D044466:Asian People / Q000235:genetics; D009202:Cardiomyopathies / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007564:Japan; D008233:Lymphotoxin-alpha / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000276:immunology*; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha