Effect of prolonged administration of transdermal estradiol on flow-mediated endothelium-dependent and endothelium-independent vasodilation in healthy postmenopausal women.
In 15 postmenopausal women with no cardiovascular risk factors, hormone replacement with transdermal estradiol (50 microg/day for 2 months) did not enhance flow-mediated endothelium-dependent vasodilation, reduce endothelium-independent vasodilation, and did not modify the pulsatility index and blood flow of the brachial artery. The present data do not support a positive effect of replacement with transdermal estradiol on vessel vasodilation in healthy, postmenopausal women.
Cagnacci
A
A
Institute of Obstetric and Gynecology, University of Modena, Italy. cagnacci@unimo.it
Modena
M G
MG
Malmusi
S
S
Muia
N
N
Volpe
A
A
D000279:Administration, Cutaneous; D001158:Arteries / Q000187:drug effects; D001783:Blood Flow Velocity; D004730:Endothelium, Vascular / Q000378:metabolism*; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008875:Middle Aged; D017698:Postmenopause; D012016:Reference Values; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*
D004958:Estradiol