title: Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic-uremic syndrome.
abstract: Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to have greater virulence for humans. STEC strains carrying eae and belonging to serogroup O157 or O111 have been responsible for the vast majority of outbreaks of STEC disease reported to date. Here we describe a STEC O113:H21 strain lacking eae that was responsible for a cluster of three cases of hemolytic-uremic syndrome. This strain produces a single Stx2-related toxin and adheres efficiently to Henle 407 cells.
authors.affiliation: Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A. 5006, Australia.
authors.forename: A W
authors.initials: AW
authors.lastname: Paton
authors.forename: M C
authors.initials: MC
authors.lastname: Woodrow
authors.forename: R M
authors.initials: RM
authors.lastname: Doyle
authors.forename: J A
authors.initials: JA
authors.lastname: Lanser
authors.forename: J C
authors.initials: JC
authors.lastname: Paton
mesh_terms: D018829:Adhesins, Bacterial; D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000097:blood; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001427:Bacterial Toxins / Q000235:genetics*; D002352:Carrier Proteins; D002648:Child; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D029968:Escherichia coli Proteins; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D022603:Shiga Toxins
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001427:Bacterial Toxins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D022603:Shiga Toxins; C073819:eaeA protein, E coli