Expression and function of CD30 on T lymphocytes.
T cell receptor, accessory molecules, cytokines are important regulatory factors that determine the development and function of T lymphocytes. Among them are also molecules belonging to superfamily of tumor necrosis factor receptor (TNFR) which beside CD30 include CD27, CD40, TNFR-I and -II, Fas (CD95), OX40, 4-1BB (CDw137), nerve growth factor receptor, lymphotoxin-beta receptor, Apo3/DR3/Ws1-1/lymphocyte associated receptor of death, DR4, DR5/TNF-related apoptosis-inducing ligand, osteoprotegerin, and TNFR-related 2. CD30 recognized originally on Reed-Sternberg cells of Hodgkin's lymphoma became of interest in studies of Th1 and Th2 cell differentiation. This paper shows recent findings regarding CD30 expression and its pleiotropic role in T cell function. It provides information about controversial role of CD30 as Th2 cell differentiation marker and gives concise insight into the function of this receptor as a signal transducing molecule.
Tarkowski
M
M
Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Lódź, Poland.
D000818:Animals; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D017730:Ki-1 Antigen; D018124:Receptors, Tumor Necrosis Factor