title: [Determination of thyroid hormone].
abstract: Measurement of total and free (F) T4 and T3 are widely used as diagnostic methods for thyroid function evaluation. Here we review the clinical usefulness of determination of T4, T3, reverse T3(rT3), FT4 and FT3 in patients with autoimmune thyroid disease (AID). Autoantibodies against thyroid hormone (THAb) are frequently detected in the serum of patients with autoantibodies against thyroglobulin (TgAb) in AID. Spuriously higher FT4 or FT3 values in recent free thyroid hormone assays [Amerlite MAb FT4(FT3) or Amerlex FT4(FT3)] by these THAb (anti-T4 or anti-T3) have been reported. Thus, discrepancy between the clinical findings and the laboratory data from thyroid function test in patients with THAb are found. Simultaneous detection of FT4(FT3) and TSH is the reasonable method to evaluate real thyroid function.
authors.affiliation: Research Institute for Production Development, Nantan General Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Ochi
authors.forename: Y
authors.initials: Y
authors.lastname: Kajita
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D011247:Pregnancy; D013959:Thyroid Diseases / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001323:Autoantibodies; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine