The role of cell adhesion molecules in synaptic plasticity and memory.
Studies in the past few years suggest that cell adhesion molecules may play signaling as well as structural roles at adult synapses during plasticity. The observation that many adhesion molecules are expressed both pre-synaptically and post-synaptically raises the possibility that information about synaptic activity might simultaneously be communicated to both sides of the synapse, circumventing the need for distinct anterograde and retrograde messengers.
Murase
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Howard Hughes Medical Institute Division of Biology California Institute of Technology 1200 East California Boulevard, Pasadena, CA 91125, USA.
Schuman
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D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D015820:Cadherins / Q000235:genetics / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D004331:Drosophila melanogaster / Q000378:metabolism; D006624:Hippocampus; D006801:Humans; D019476:Insect Proteins / Q000502:physiology; D016023:Integrins / Q000502:physiology; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009842:Oligopeptides / Q000737:chemistry; D013569:Synapses / Q000502:physiology
D015820:Cadherins; D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D019476:Insect Proteins; D016023:Integrins; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid