HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus.
OBJECTIVE. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE).


METHODS
We studied HLA-DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method.


RESULTS
The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE.


CONCLUSIONS
HLA-DMA*0104 may be associated with the susceptibility of SLE.
Yen
J H
JH
Department of Internal Medicine, Kaohsiung Medical College, Taiwan.
Chen
C J
CJ
Tsai
W C
WC
Tsai
J J
JJ
Ou
T T
TT
Liu
H W
HW
D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006681:HLA-D Antigens / Q000032:analysis*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013624:Taiwan
D005819:Genetic Markers; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II