Asymmetric synthesis and antitumor activity of cycloalkanin.
Cycloalkanin was accessible by a practical and efficient asymmetric synthesis. The chiral center of the target is introduced via an asymmetric C-arylation of chiral aldehyde in high de. The synthesized cycloalkanin was shown to be significantly active against P388 cell line as assayed by in vitro MIT method.
Wu
X
X
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China.
Xu
L
L
Cai
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388 / Q000473:pathology*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009285:Naphthoquinones