[Ulcerative stomatitis as clinical clue to inadvertent methotrexate overdose].
Gastrointestinal side effects and the development of toxic liver fibrosis are well-known side effects of low dose methotrexate therapy. A female patient receiving a long term low dose methotrexate therapy for a seronegative chronic polyarthritis developed an ulcerative stomatitis, as clinical clue to an inadvertently given methotrexate overdose. A summary of other side effects of methotrexate and of oral side effects of other cytostatic agents and immunosuppressive drugs is given.
Bauer
J
J
Dermatologische Universitätsklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg.
Fartasch
M
M
Schuler
G
G
Schell
H
H
D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008508:Medication Errors; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D019226:Oral Ulcer / Q000139:chemically induced* / Q000473:pathology; D013280:Stomatitis / Q000139:chemically induced* / Q000473:pathology
D018501:Antirheumatic Agents; D008727:Methotrexate