Regulation of inducible gene expression by the transcription factor NF-kappaB.
The transcription factor NF-kappaB plays a critical role in regulating inducible gene expression in immune responses. The activation of NF-kappaB is regulated at multiple levels, probably reflecting a need to maintain a tight control of its activity. We have recently discovered that direct phosphorylation of NF-kappaB itself is essential for its transcriptional activity and that phosphorylation acts as a switch to determine association of nuclear NF-kappaB with histone acetylases vs deacetylases.
Ghosh
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Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06526, USA. sankar.gosh@yale.edu
D000818:Animals; D050882:CREB-Binding Protein; D002135:Calcium-Binding Proteins; D017868:Cyclic AMP-Dependent Protein Kinases; D005786:Gene Expression Regulation; D006655:Histone Deacetylases; D006801:Humans; D008562:Membrane Glycoproteins; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D010766:Phosphorylation; D050857:Synaptotagmins; D015534:Trans-Activators; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D050857:Synaptotagmins; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; D017868:Cyclic AMP-Dependent Protein Kinases; D006655:Histone Deacetylases