title: Cybernetic modeling of spontaneous oscillations in continuous cultures of Saccharomyces cerevisiae.
abstract: We have developed a 'cybernetic' model to simulate the dynamic competition between all the available metabolic pathways of yeast Saccharomyces cerevisiae. This computer model predicts all the key experimentally observed aspects of the sustained oscillations in all the measured concentrations in continuous cultures, such as the spontaneous generation of oscillations as well as the variations in period and amplitude of oscillations when the dilution rate or agitation rate are changed.
authors.affiliation: Department of Chemical Engineering, University of Colorado, Boulder 80309-0424, USA. kompala@colorado.edu
authors.forename: D S
authors.initials: DS
authors.lastname: Kompala
mesh_terms: D003198:Computer Simulation; D012441:Saccharomyces cerevisiae / Q000254:growth & development / Q000378:metabolism*