Dystroglycan inside and out.
Dystroglycan connects the extracellular matrix and cytoskeleton. Key findings in the past year indicate that dystroglycan interacts with a wider repertoire of extracellular ligands than originally appreciated, that dystroglycan plays a critical role in organizing extracellular matrix molecules on the cell surface and in basement membranes, and that at least two human pathogens utilize dystroglycan to gain access to host cells. Together, these advances begin to help elucidate important biological roles for dystroglycan in development and disease.
Henry
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Howard Hughes Medical Institute Department of Physiology and Biophysics Department of Neurology University of Iowa College of Medicine 400 Eckstein Medical Research Building, Iowa City, IA 52242, USA. michael-henry@uiowa.edu.
Campbell
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D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001422:Bacterial Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D049030:Dystroglycans; D005109:Extracellular Matrix / Q000378:metabolism; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D051380:GRB2 Adaptor Protein; D006801:Humans; D007797:Laminin / Q000378:metabolism; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology; D009136:Muscular Dystrophies / Q000378:metabolism; D009166:Mycobacterium leprae / Q000378:metabolism; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011506:Proteins / Q000502:physiology; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; D007797:Laminin; D008024:Ligands; D008562:Membrane Glycoproteins; D009124:Muscle Proteins; D011506:Proteins; C051609:peripheral membrane protein 43K; D049030:Dystroglycans; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human