Regular exercise, plasminogen activator inhibitor-1 (PAI-1) activity and the 4G/5G promoter polymorphism in the PAI-1 gene.
The aim of this controlled randomised clinical trial was to investigate the effects of regular low to moderate intensity physical activity on plasminogen activator inhibitor-1 (PAI-1) activity during three years while taking into account the 4G/5G polymorphism in the promoter of the PAI-1 gene. Male subjects (age 52-62 years, n = 132) were randomised into an exercise or a (non-intervention) reference group. Aerobic threshold increased by 8.8% (p = 0.025) in the exercise group, and decreased by 1.1% in the non-intervention group, while PAI-1 activity did not change significantly in either study group. However, homozygotes for the 4G allele in the exercise group showed a 36% reduction in PAI-1 (p = 0.025). In conclusion, although regular moderate physical activity did not decrease PAI-I activity in the whole group, regular exercise may be effective for controlling elevated PAI-1 level in subjects homozygous for the 4G allele.
Väisänen
S B
SB
Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland. sari.vaisanen@uku.fi
Humphries
S E
SE
Luong
L A
LA
Penttilä
I
I
Bouchard
C
C
Rauramaa
R
R
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis / Q000235:genetics / Q000502:physiology; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D017931:DNA Primers; D017395:Plasminogen Activator Inhibitor 1