title: Association of Lewis blood group with ischaemic heart disease.
abstract: A total of 96 patients (74 males and 22 females) with ischaemic heart disease (IHD) who presented at a hospital in north India for cardiac bypass surgery, percutaneous coronary angioplasty or unstable angina were investigated for Lewis blood group phenotypes. A hundred and four normal healthy blood donors matched for age and sex served as controls. Lewis blood group typing was carried out on red cells using saline haemagglutination technique in a test tube with monoclonal antisera. 29.1 per cent of IHD patients had Le(a-b-) phenotype compared to 9.6 per cent of controls (P < 0.01). The relative risk of IHD for Le(a-b-) phenotype was found to be highly significant (risk = 3.87). We conclude that there is an increased frequency of Le(a-b-) phenotype among Indian patients with IHD.
authors.affiliation: Department of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
authors.forename: R
authors.initials: R
authors.lastname: Chaudhary
authors.forename: J S
authors.initials: JS
authors.lastname: Shukla
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007983:Lewis Blood Group Antigens; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000209:etiology; D012307:Risk Factors
chemical_list: D007983:Lewis Blood Group Antigens