title: Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor.
abstract: A novel series of 5,6,7,8-tetrahydroquinazolines, 4,5,6,7-tetrahydroindazoles and 4,5,6,7-tetrahydrobenzothiazoles has been prepared, having high affinity and selectivity for the dopamine D3 receptor. The 4-methoxy-5,6,7,8-tetrahydroquinazoline 6i and 2-amino-4,5,6,7-tetrahydrobenzothiazole 8 proved to be agonists with among the highest D3 receptor affinities and selectivities reported to date.
authors.affiliation: SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK.
authors.forename: K Y
authors.initials: KY
authors.lastname: Avenell
authors.forename: I
authors.initials: I
authors.lastname: Boyfield
authors.forename: M S
authors.initials: MS
authors.lastname: Hadley
authors.forename: C N
authors.initials: CN
authors.lastname: Johnson
authors.forename: D J
authors.initials: DJ
authors.lastname: Nash
authors.forename: G J
authors.initials: GJ
authors.lastname: Riley
authors.forename: G
authors.initials: G
authors.lastname: Stemp
mesh_terms: D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006571:Heterocyclic Compounds; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D013764:Tetrahydronaphthalenes; C006561:2-aminotetralin