title: The utility of endoscopic ultrasonography and endoscopy in the endoscopic mucosal resection of early gastric cancer.
abstract: OBJECTIVE
  To clarify the usefulness of endoscopic ultrasonography (EUS) and endoscopy in the endoscopic mucosal resection (EMR) of early gastric cancer. Patients/Methods-EMR was performed in 61 patients with early gastric cancer over the past five years. The accuracy of the assessment of the depth of cancerous invasion was studied in 49 patients who had EUS before EMR. Forty eight patients were treated with endoscopy alone; in these patients, EUS and endoscopic findings correlated with the clinical course.
  
  
  RESULTS
  Forty six patients showed no changes in the submucosal layer or deeper structures on EUS. Pathologically these included 37 patients with mucosal cancer and nine with submucosal cancer showing very slight submucosal infiltration. Three patients showed diffuse low echo changes in the submucosal layer on EUS; pathologically, these included two with submucosal cancer and one with mucosal cancer with a peptic ulcer scar within the tumour focus. Of 48 patients receiving endoscopic treatment alone, 45 showed no tumour recurrence or evidence of metastases on EUS and endoscopy. Three cases of recurrence were observed. Two of these patients had a surgical gastrectomy, and one was re-treated endoscopically. In the former cases, the surgical results correlated well with assessment by EUS and endoscopy. In addition, the latter patient who was re-treated endoscopically after evaluation with EUS and endoscopy has so far had no recurrence.
  
  
  CONCLUSIONS
  The combined use of EUS and endoscopy is effective in diagnosing the depth of cancerous invasion in patients undergoing EMR as well as in clarifying changes both within and between anatomic levels during follow up.
authors.affiliation: Department of Gastroenterology, Toyohashi City Hospital, Aotake-cho 50, Toyohashi 441, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohashi
authors.forename: K
authors.initials: K
authors.lastname: Segawa
authors.forename: S
authors.initials: S
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Mitake
authors.forename: H
authors.initials: H
authors.lastname: Urano
authors.forename: M
authors.initials: M
authors.lastname: Shimodaira
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: S
authors.initials: S
authors.lastname: Kanamori
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: B
authors.initials: B
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D000368:Aged; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*