Lessons from the rifamycin biosynthetic gene cluster.
There is currently intense interest in unravelling the modus operandi of type I modular polyketide synthases in order to lay the ground work for their use in the combinatorial biosynthesis of new bioactive molecules. Much of our knowledge is derived from studies on 6-deoxyerythronolide B (DEBS), the enzyme assembling the polyketide backbone of erythromycin. Work on the rifamycin polyketide synthase has revealed a number of features that differ from those seen with DEBS.
Floss
H G
HG
Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA. floss@chem.washington.edu.
Yu
T W
TW
D008956:Models, Chemical; D009097:Multienzyme Complexes / Q000378:metabolism; D005810:Multigene Family; D012294:Rifamycins / Q000096:biosynthesis*
D009097:Multienzyme Complexes; D012294:Rifamycins