Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.
Yin Yang 1 (YY1) is a zinc finger-containing transcription factor and a target of viral oncoproteins. To determine the biological role of YY1 in mammalian development, we generated mice deficient for YY1 by gene targeting. Homozygosity for the mutated YY1 allele results in embryonic lethality in the mouse. YY1 mutants undergo implantation and induce uterine decidualization but rapidly degenerate around the time of implantation. A subset of YY1 heterozygote embryos are developmentally retarded and exhibit neurulation defects, suggesting that YY1 may have additional roles during later stages of mouse embryogenesis. Our studies demonstrate an essential function for YY1 in the development of the mouse embryo.
Donohoe
M E
ME
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Zhang
X
X
McGinnis
L
L
Biggers
J
J
Li
E
E
Shi
Y
Y
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D010064:Embryo Implantation / Q000235:genetics*; D050981:Erythroid-Specific DNA-Binding Factors; D005260:Female; D005804:Genes, Lethal; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008817:Mice, Mutant Strains / Q000196:embryology*; D009436:Neural Tube Defects; D014157:Transcription Factors / Q000235:genetics*; D050986:YY1 Transcription Factor
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D014157:Transcription Factors; D050986:YY1 Transcription Factor; C494699:Yy1 protein, mouse