title: Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis.
abstract: In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.
authors.affiliation: Department of Physiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: E
authors.initials: E
authors.lastname: Cantu
authors.forename: C
authors.initials: C
authors.lastname: Demartino
authors.forename: A
authors.initials: A
authors.lastname: Vladutiu
authors.forename: P R
authors.initials: PR
authors.lastname: Caldwell
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: V
authors.initials: V
authors.lastname: D'Agati
authors.forename: G
authors.initials: G
authors.lastname: Godman
authors.forename: D M
authors.initials: DM
authors.lastname: Stern
authors.forename: G
authors.initials: G
authors.lastname: Andres
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004727:Endothelium / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry; D015433:Glomerulonephritis, Membranous / Q000201:enzymology* / Q000276:immunology / Q000473:pathology*; D000882:Haplorhini; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D051379:Mice; D018613:Microscopy, Confocal; D007703:Peptidyl-Dipeptidase A / Q000276:immunology*; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D012680:Sensitivity and Specificity; D012710:Serum Albumin, Bovine / Q000276:immunology; D013045:Species Specificity; D013552:Swine
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D007703:Peptidyl-Dipeptidase A