Monitoring of radical scavenging activity of peroral administration of the Kampo medicine Sho-saiko-to in rats.
The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (*OH) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for Ka (absorption rate constant), Tmax (peak concentration time), T1/2 (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, *OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.
Egashira
T
T
Department of Pharmacology, Oita Medical University, Hasama-machi, Japan.
Takayama
F
F
Yamanaka
Y
Y
Komatsu
Y
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015764:Bepridil / Q000031:analogs & derivatives* / Q000378:metabolism; D001713:Biphenyl Compounds; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000097:blood / Q000378:metabolism; D007564:Japan; D020835:Medicine, Kampo; D010851:Picrates; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013481:Superoxides / Q000097:blood / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; D017665:Hydroxyl Radical; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl