title: Splanchnic hemodynamics and gut mucosal-arterial PCO(2) gradient during systemic hypocapnia.
abstract: The effects of hypocapnia [arterial PCO(2) (Pa(CO(2))) 15 Torr] on splanchnic hemodynamics and gut mucosal-arterial P(CO(2)) were studied in seven anesthetized ventilated dogs. Ileal mucosal and serosal blood flow were estimated by using laser Doppler flowmetry, mucosal PCO(2) was measured continuously by using capnometric recirculating gas tonometry, and serosal surface PO(2) was assessed by using a polarographic electrode. Hypocapnia was induced by removal of dead space and was maintained for 45 min, followed by 45 min of eucapnia. Mean Pa(CO(2)) at baseline was 38.1 +/- 1.1 (SE) Torr and decreased to 13.8 +/- 1.3 Torr after removal of dead space. Cardiac output and portal blood flow decreased significantly with hypocapnia. Similarly, mucosal and serosal blood flow decreased by 15 +/- 4 and by 34 +/- 7%, respectively. Also, an increase in the mucosal-arterial PCO(2) gradient of 10.7 Torr and a reduction in serosal PO(2) of 30 Torr were observed with hypocapnia (P < 0.01 for both). Hypocapnia caused ileal mucosal and serosal hypoperfusion, with redistribution of flow favoring the mucosa, accompanied by increased PCO(2) gradient and diminished serosal PO(2).
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Guzman
authors.forename: J A
authors.initials: JA
authors.lastname: Kruse
mesh_terms: D000472:Alkalosis, Respiratory / Q000097:blood / Q000503:physiopathology; D000818:Animals; D001158:Arteries / Q000378:metabolism; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D006339:Heart Rate / Q000502:physiology; D016857:Hypocapnia / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D012126:Respiratory Dead Space / Q000502:physiology; D013152:Splanchnic Circulation / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen