title: Phase-trafficking reagents and phase-switching strategies for parallel synthesis.
abstract: Strategies for the parallel synthesis of small molecule arrays are reviewed with an emphasis on those approaches that integrate the sciences of organic synthesis and product purification. The use of phase-trafficking reagents (PTRs) and phase-switching strategies are highlighted, which allow the rapid, parallel synthesis of small molecule arrays with built-in purification determinants.
authors.affiliation: Amgen, INC, One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Flynn
mesh_terms: D000215:Acylation; D000478:Alkylation; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry*; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D009930:Organic Chemicals