title: Pupillary responses evoked during verbal fluency tasks indicate semantic network dysfunction in schizophrenia.
abstract: Pupillary responses, which index task controlled processing load, were recorded during semantic and phonemic fluency tasks to examine controlled search and automatic semantic network deficits in patients with schizophrenia. Word retrieval was more impaired on semantic than on phonemic fluency, but only during the first 15 seconds of trials. Pupillary dilation was greater on phonemic than on semantic fluency in nonpsychiatric participants but was greater on semantic than on phonemic fluency in the patients, during the first 15 seconds of trials. Thus, early in semantic fluency trials, patients with schizophrenia showed poorer word retrieval and abnormally high demand for frontal lobe controlled search processes, suggesting impairments in the temporal lobe automatic semantic memory processes that normally facilitate word retrieval.
authors.affiliation: Department of Psychiatry, University of California, San Diego, USA. egranholm@ucsd.edu
authors.forename: E
authors.initials: E
authors.lastname: Granholm
authors.forename: D
authors.initials: D
authors.lastname: Chock
authors.forename: S
authors.initials: S
authors.lastname: Morris
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D010700:Phonetics; D012025:Reflex, Pupillary / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012660:Semantics; D013702:Temporal Lobe / Q000503:physiopathology; D014706:Verbal Learning / Q000502:physiology; D014825:Vocabulary