Role of fatty acid beta-oxidation and calcium-independent phospholipase A2 in ischemic acute renal failure.
Membrane phospholipolysis during ischemic cell injury is accompanied by the activation of a novel calcium-independent phospholipase A2 in the proximal tubule. Long-chain fatty acid metabolic products produced by phospholipase A2 activation accumulate during ischemia as a result of the inhibition of fatty acid beta-oxidation on the mitochondria and peroxisomes. Altogether, lysophospholipids, long-chain acyl carnitines, and long-chain acyl coenzyme A inhibit proximal tubule Na+K(+)-ATPase. Metabolic regulation of the gene expression of fatty acid beta-oxidation enzymes during ischemic acute renal failure may represent a novel therapeutic maneuver to enhance the recovery of kidney function during ischemia.
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Department of Medicine, University of Arkansas for Medical Science, Little Rock 72205, USA.
D058186:Acute Kidney Injury / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2
D005227:Fatty Acids; D010741:Phospholipases A; D054467:Phospholipases A2; D002118:Calcium