title: Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis.
abstract: Studies of the association between HHV-6 and multiple sclerosis are hindered by the difficulty in discriminating between latent and active infection. A follow up study was undertaken of patients with multiple sclerosis, searching peripheral blood mononuclear cells for molecular markers associated with HHV-6 latency and lytic replication. The results show that HHV-6 is latent and did not support systemic infection in patients with multiple sclerosis. Likewise, patients with multiple sclerosis did not show any evidence of active infection with other human herpesviruses HHV-7 and HHV-8.
authors.affiliation: Departments of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rotola
authors.forename: E
authors.initials: E
authors.lastname: Cassai
authors.forename: M R
authors.initials: MR
authors.lastname: Tola
authors.forename: E
authors.initials: E
authors.lastname: Granieri
authors.forename: D
authors.initials: D
authors.lastname: Di Luca
mesh_terms: D000293:Adolescent; D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D015654:Herpesvirus 6, Human / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000821:virology*; D016133:Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral