HLA antigens in patients with variant angina in Japan.
There have been few reports on examining the susceptibility of variant angina. Accordingly, the major histocompatibility complexes (HLA-A, -B, -C, -DR) of unrelated Japanese patients with variant angina were examined. There were no significant differences in the frequency of HLA-A,-B, -C, and -DR antigens between patients and controls (n = 100). Although endothelial dysfunction with pathological abnormalities is suggested to be one of the etiological factors in vasospasm, immunogenetic abnormalities linked to HLA system might not play a role in the pathogenesis of variant angina.
Kishimoto
C
C
The Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. kkishi@kuhp.kyoto-u.ac.jp
Lee
J D
JD
Shimizu
H
H
Ueda
T
T
Maruya
E
E
Saji
H
H
D000328:Adult; D000368:Aged; D000788:Angina Pectoris, Variant / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens