P760 and P775: MRI contrast agents characterized by new pharmacokinetic properties.
OBJECTIVE
In this paper we discuss novel MR imaging blood pool agents characterized by new pharmacokinetic properties.


METHODS
The pharmacokinetics of the products were studied in a rabbit model. The potential of these new products was demonstrated in experimental MR imaging.


CONCLUSIONS
Three main classes of blood pool agents have been defined and characterized according to their pharmacokinetic properties: low diffusion agents, rapid clearance blood pool agents, slow clearance blood pool agents. Each kind of blood pool agent is expected to have different diagnostic applications.
Port
M
M
GUERBET, Department of Research, Roissy, France. portm@guerbet-group.com
Meyer
D
D
Bonnemain
B
B
Corot
C
C
Schaefer
M
M
Rousseaux
O
O
Simonot
C
C
Bourrinet
P
P
Benderbous
S
S
Dencausse
A
A
Devoldere
L
L
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D006207:Half-Life; D006571:Heterocyclic Compounds / Q000097:blood; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D009942:Organometallic Compounds / Q000097:blood*; D011817:Rabbits
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C120577:gadolinium compound P760; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate