Hypoglycaemic activity of alpha, alpha trehalose-6-phosphate.
Alpha-alpha-trehalose-6-phosphate, synthesized by Oke was screened for hypoglycaemic activity. Alloxan-induced diabetic albino rats and fasted-rabbits were used in the study. The inhibitory activity of trehalose-6-phosphate on trehalase was also assayed. The study shows that alpha-alpha-trehalose-6-phosphate is a glucose analogue with potent anti-hyperglcaemic activity as shown by its hypoglycaemic response in fasted rabbits. The ability of alpha-alpha-trehalose-6-phosphate to attenuate the diabetic toxicity in alloxan-induced diabetic rats confirmed its potent anti-diabetic activity. The mechanism of action of this synthesized compound may be linked with its ability to inhibit trehalase, and increase the activity of the superoxidase dimutase present in the beta-cells of the alloxan-diabetic rats and also being a glucose analogue according to Puls principle, alpha-alpha-trehalose-6-phosphate is able to influence the intermediate metabolism of carbohydrate.
Oke
J M
JM
London School of Pharmacy, University of London.
Watt
R A
RA
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006593:Hexokinase / Q000037:antagonists & inhibitors*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013403:Sugar Phosphates / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors; D014199:Trehalose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D013403:Sugar Phosphates; C082722:trehalose-6-phosphate; D000496:Alloxan; D014199:Trehalose; D006593:Hexokinase