Assessment of ethanol intake. Current tests and new assays on the horizon.
The number of tests used for the detection of ethanol ingestion is increasing. The field is rapidly moving beyond ethanol alone as a marker of ethanol intake. The combined measurement of carbohydrate deficient transferrin, FAEEs, 5-HTOL/5-HIAA, acetaldehyde adducts, and phosphatidylethanol may one day be used to approximate the time and amount of ethanol ingestion. The ultimate configuration of a panel of tests for monitoring ethanol intake awaits the results of studies that identify the clinical usefulness of each marker.
Laposata
M
M
Department of Pathology, Massachusetts General Hospital, Boston 02114-2696, USA.
D000079:Acetaldehyde / Q000032:analysis; D000435:Alcoholic Intoxication / Q000175:diagnosis*; D015415:Biomarkers / Q000032:analysis; D002849:Chromatography, Gas; D000431:Ethanol / Q000032:analysis*; D020404:Glycerophospholipids / Q000032:analysis; D006801:Humans; D006917:Hydroxytryptophol / Q000032:analysis; D007525:Isoelectric Focusing; D012463:Saliva / Q000737:chemistry; D014168:Transferrin / Q000031:analogs & derivatives / Q000032:analysis; D014822:Vitreous Body / Q000737:chemistry
D015415:Biomarkers; D020404:Glycerophospholipids; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; C051521:phosphatidylethanol; D006917:Hydroxytryptophol; D000431:Ethanol; D000079:Acetaldehyde