Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells.
The exposure of human lymphoid leukemia Molt 4B cells to phytol which was isolated from Lolium multiflorum Lam and identified by MS, and 1H- and 13C-NMR, led to both growth inhibition and the induction of programmed cell death (apoptosis). Morphological change showing apoptotic bodies was observed in the cells treated with phytol. The fragmentation by phytol of DNA to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition by phytol of Molt 4B cells results from the induction of apoptosis in the cells.
Komiya
T
T
Faculty of Bioresources, Mie University, Tsu-city, Mie 514-0001, Japan.
Kyohkon
M
M
Ohwaki
S
S
Eto
J
J
Katsuzaki
H
H
Imai
K
K
Kataoka
T
T
Yoshioka
K
K
Ishii
Y
Y
Hibasami
H
H
D017209:Apoptosis / Q000187:drug effects*; D053938:DNA Fragmentation / Q000187:drug effects; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D008129:Lolium; D010836:Phytol / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D010836:Phytol