Expression of Chlamydia psittaci- and human immunodeficiency virus-derived antigens on the cell surface of Lactobacillus fermentum BR11 as fusions to bspA.
The basic surface protein, BspA, has been used as a fusion partner to direct peptide antigens from the human immunodeficiency virus gp41 protein and the Chlamydia psittaci OmpA protein to the cell surface of Lactobacillus fermentum BR11. BspA has potential utility in the construction of live vaccines and diagnostic reagents.
Turner
M S
MS
Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Giffard
P M
PM
D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis*; D001426:Bacterial Proteins; D006168:Guinea Pigs; D015700:HIV Envelope Protein gp41 / Q000096:biosynthesis*; D007778:Lactobacillus / Q000235:genetics*; D008565:Membrane Proteins / Q000096:biosynthesis*; D011993:Recombinant Fusion Proteins / Q000032:analysis / Q000096:biosynthesis*
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C105995:BspA protein, bacteria; D015700:HIV Envelope Protein gp41; D008565:Membrane Proteins; D011993:Recombinant Fusion Proteins; C078167:OMPA outer membrane proteins