The role of the pineal gland in forming a conditioned reflex to time in rats.
The effects of pinealectomy and melatonin on time-associated conditioned reflex behavior were studied. Removal of the pineal gland hindered the formation of a conditioned reflex in conditions of a fixed time interval in rats. This was accompanied by a shortening of latency and excursions and an increase in the number of intersignal responses. Administration of melatonin (0.1 mg/kg) had the opposite effects, facilitating the development of the conditioned response to time and limiting motor activity.
Arushanyan
E B
EB
Medical Academy, State University, Stavropol'.
Vodolazhskaya
M G
MG
D000161:Acoustic Stimulation; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D008550:Melatonin