[The adaptational intracellular mechanisms regulating energy homeostasis during intermittent normobaric hypoxia].
Rats trained to intermittent normobaric hypoxia (INH) developed an increase of the glycogen contents in the heart and liver parenchymatous cells. Fatty acids seem to be the main source for synthesis of the intracellular glycogen. The intracellular transformation of the lipid energy substrate into the carbohydrates maintains the energy homeostasis in hepatocytes and cardiomyocytes during hypoxic intervals of the INH thus creating the necessary conditions. This kind of regulating the substance supply of the cell energy supports the organism stability under various effects.
Lebkova
N P
NP
Russian Medical Academy of Postgraduation Education, Moscow, Russia.
Chizhov
A Ia
AIa
Bobkov
Iu I
IuI
D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006321:Heart / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology*; D000860:Hypoxia / Q000473:pathology / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar