[Platelet aggregation test in specific immunotherapy].
The aim of study was to investigate the effect of a specific immunotherapy (sIT) on the results of the platelet aggregation test (agregometr, chronolog Corp. Broomall, Pa model 345) in patients with inhalant allergy. The trial consisted of 57 patients with seasonal allergic rhinitis (exclusively allergic to grass pollens) and 55 patients with perennial allergic rhinitis sensitive to house dust mite Dermatophagoides pteronyssinus. sIT was applied in only 29 patients suffering from pollinosis and 27 sensitive to house dust mite. The remaining patients were subjected to routine pharmacotherapy alone. The control group consisted of 30 laboratory workers with no history of atopy. Platelet aggregation test was performed before sIT and after 2 years course of treatment and finally revealed the partial improvement of the impaired aggregation capacity of platelets which suggest their involvement in the mechanism of sIT. There was no correlation between the platelets function and IgE serum level and the clinical efficacy of sIT as well.
Rogala
B
B
Klinika Chorób Wewnetrznych i Alergologii, Slaskiej Akademii Medycznej w Katowicach.
Gumprecht
J
J
D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008925:Mites; D010974:Platelet Aggregation / Q000276:immunology*; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology* / Q000628:therapy*