title: Cystoid macular edema after cataract surgery with intraocular vancomycin.
abstract: OBJECTIVE
  To determine whether the use of supplemental prophylactic vancomycin in the irrigating solution during extracapsular lens extraction is associated with increased incidence of cystoid macular edema.
  
  
  METHODS
  Prospective, randomized, double-masked clinical study.
  
  
  METHODS
  Consecutive series of 118 patients 60 years of age or older undergoing cataract surgery.
  
  
  METHODS
  The study group received an irrigating balanced salt solution supplemented with vancomycin (10 microg/ml), and the control group received the salt solution only. Fluorescein angiography was performed 1 and 4 months after surgery.
  
  
  METHODS
  Evidence of angiographic and clinical cystoid macular edema, and visual acuity at 1 and 4 months after surgery.
  
  
  RESULTS
  The rate of postoperative angiographic cystoid macular edema was significantly higher in the study patients than in the control group at 1 month (55% vs. 19%, P = 0.0006) and 4 months (26% vs. 4%, P = 0.0099). The rates of clinical macular edema were 23% and 7%, respectively, at 1 month (P = 0.011) and 20% versus 0% at 4 months (P = 0.006). Visual acuity of 20/30 or better was noted at 4 months after surgery in 76% of the study group compared to 95.5% of the control group.
  
  
  CONCLUSIONS
  The role of preventive intracameral vancomycin during intraocular surgery should be reassessed in view of the associated increase in the incidence of angiographic cystoid macular edema.
authors.affiliation: Department of Ophthalmology, Rabin Medical Center, Petah Tiqva, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Axer-Siegel
authors.forename: H
authors.initials: H
authors.lastname: Stiebel-Kalish
authors.forename: I
authors.initials: I
authors.lastname: Rosenblatt
authors.forename: E
authors.initials: E
authors.lastname: Strassmann
authors.forename: Y
authors.initials: Y
authors.lastname: Yassur
authors.forename: D
authors.initials: D
authors.lastname: Weinberger
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002387:Cataract Extraction / Q000009:adverse effects / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D015994:Incidence; D019654:Lens Implantation, Intraocular; D008269:Macular Edema / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014640:Vancomycin / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin