title: Optimal stimulus duration for intraoperative facial nerve monitoring.
abstract: OBJECTIVE
  The charge delivered to the facial nerve during intraoperative facial nerve monitoring (IOFNM) is the product of the stimulation amplitude and the duration for which the pulse of charge is applied. In the literature, no standard for pulse duration exists, precluding meaningful comparison of IOFNM between studies. The optimal stimulus pulse duration can be derived from facial nerve strength duration curve analysis and calculation of chronaxy. Chronaxy is directly related to the time constant, tau, of the neuronal membrane, and is a function of neuronal membrane resistance and capacitance.
  
  
  METHODS
  A prospective trial of facial nerve stimulation in both an animal and a human model.
  
  
  METHODS
  Five rabbits and 17 humans underwent intraoperative stimulation of healthy facial nerves. Pulse durations using pulses of 10, 20, 50, and 100 microseconds were employed, and the corresponding threshold stimulation amplitudes were recorded. From these data sets, strength duration curves were plotted and chronaxy values calculated.
  
  
  RESULTS
  Average chronaxy values of 18 microseconds in the rabbit and 32 microseconds in the human were found. Given IOFNM system accuracy limitations, the optimal pulse duration for facial nerve stimulation is 50 microseconds.
  
  
  CONCLUSIONS
  Most commercially available intraoperative monitoring systems employ a pulse duration default setting of 100 microseconds. Doubling of the 50-microsecond optimal pulse duration may result in a loss of sensitivity of predictive facial nerve data. Both the stimulation amplitude and the selected pulse duration should be reported by investigators so that meaningful comparison of the IOFNM data in the literature can be made.
authors.affiliation: Department of Otorhinolaryngology, Weill College of Medicine of Cornell University, New York, NY 10021, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Selesnick
mesh_terms: D000818:Animals; D004576:Electromyography; D005154:Facial Nerve / Q000502:physiology*; D006801:Humans; D008297:Male; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods*; D010865:Pilot Projects; D011446:Prospective Studies; D011817:Rabbits; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors