title: Cancer risk in patients with earlier diagnosis of cutaneous melanoma in situ.
abstract: We calculated the short-term and long-term risks of developing cancer among 3,766 patients with a diagnosis of cutaneous melanoma in situ in Sweden from 1958 to 1992. In total, 393 patients developed a primary cancer at any site compared with an expected number of 177 [standardized incidence ratio (SIR) = 2.2, 95% confidence interval (CI) = 2.0-2.4]. Patients below 60 years of age at diagnosis had the highest SIR (2.7, 95% CI = 2.3-3.2). The overall risks were similar between men and women. The highest risk was seen during the first year of follow-up, though the risk remained elevated also after 15 or more years of follow-up. For specific sites, the highest SIR was found for developing invasive cutaneous malignant melanoma (SIR = 22.2). The risk of subsequent primary non-melanoma skin cancer was elevated 8-fold in men and almost 7-fold in women. An elevated risk was also found for female breast cancer (SIR = 1.4). Especially among women, other sites with increased cancer risk (though not significant) were non-Hodgkin's lymphoma (SIR = 1.9), multiple myeloma (3.2) and cancers of the colon (1.6) and pancreas (1.6). In conclusion, patients with melanoma in situ run a generally increased risk of developing primary cancers, especially cutaneous malignant melanoma and non-melanoma skin cancer. The increased long-term risk of cancer after diagnosis of melanoma in situ may be due to continuing carcinogenic exposure or to intrinsic tumor susceptibility.
authors.affiliation: Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Wassberg
authors.forename: M
authors.initials: M
authors.lastname: Thörn
authors.forename: J
authors.initials: J
authors.lastname: Yuen
authors.forename: T
authors.initials: T
authors.lastname: Hakulinen
authors.forename: U
authors.initials: U
authors.lastname: Ringborg
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications*; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D012306:Risk; D012737:Sex Factors; D012878:Skin Neoplasms / Q000150:complications*