title: Effect of blood flow rate on thrombogenesis in a rabbit extracorporeal circulation model.
abstract: Blood flow is believed to affect the thrombogenicity of extracorporeal circulation (ECC). The purpose of this study was to look at the relationship between blood flow and thrombogenicity in a rabbit model of ECC. Rabbits were anesthetized and systematically heparinized. Bilateral jugular cannulation was performed, and the animals were placed on venovenous ECC. The circuits were composed of 1 m of 1/4 inch size surgical grade polyvinylchloride (PVC) tubing. ECC was maintained for 4 hours. Three experimental groups were studied: a high flow group (n=7; flow rate: 30 ml/min/Kg), low flow group (n=7; flow rate: 10 ml/mg/Kg), and no ECC group (n=7). Platelet count, fibrinogen concentration, PaO2/FiO2, and postmortem findings were evaluated. Platelet consumption was higher with high flow, and fibrinogen consumption was higher with low flow.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, USA.
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: G M
authors.initials: GM
authors.lastname: Annich
authors.forename: J P
authors.initials: JP
authors.lastname: Meinhardt
authors.forename: S
authors.initials: S
authors.lastname: Ichiba
authors.forename: D O
authors.initials: DO
authors.lastname: Brant
authors.forename: R H
authors.initials: RH
authors.lastname: Bartlett
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D005112:Extracorporeal Circulation; D005340:Fibrinogen / Q000378:metabolism; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D011817:Rabbits; D013927:Thrombosis / Q000209:etiology*
chemical_list: D005340:Fibrinogen