Mucoid presentation of acute enterocolitis in children: a hospital-based case-control study.
A hospital-based case-control study was carried out to clarify the characteristics of mucoid presentation of acute enterocolitis in children. One hundred sixty-eight cases of acute mucoid enterocolitis (study population) were compared with 200 cases of watery diarrhoea and 118 cases of blood dysentery (control groups) on the basis of clinical characteristics and findings on stool examination. Study and control groups were comparable with respect to age, body weight and nutritional status. There was no significant difference in clinical characteristics (duration of diarrhoea, stool frequency, presence of vomiting, fever and dehydration) between patients suffering from mucoid enterocolitis and blood dysentery. However, watery diarrhoea patients had significantly high frequencies of vomiting (p=0.00001) and dehydration (p=0.00001). High numbers of microscopic red blood cells (mean +/- SD: 40.8 +/- 16.8) and white blood cells (40.6 +/- 18.0) were present in faecal samples of the patients with mucoid enterocolitis, which is indicative of infection caused by enteroinvasive enteropathogens. Shigella was a commonly identified enteropathogen in patients with mucoid enterocolitis (40.5%) and in patients with dysentery (46.6%), with no statistically significant difference (p = 0.30). Isolation of Salmonella was statistically similar in study and control groups. However, Entamoeba histolytica was detected in significantly high frequency in patients with mucoid enterocolitis as compared to the patients with dysentery (p = 0.0004) and watery diarrhoea (p = 0.00004). Our results indicate that mucoid enterocolitis patients are infected with enteroinvasive enteropathogens, and that stool examination is useful in establishing the aetiological diagnosis.
Dutta
P
P
Division of Clinical Medicine, National Institute of Cholera and Enteric Diseases, Calcutta, India. icmrnicd@ren.nic.in
Mitra
U
U
Saha
D R
DR
Niyogi
S K
SK
Manna
B
B
Bhattacharya
S K
SK
D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology; D004403:Dysentery / Q000175:diagnosis / Q000382:microbiology / Q000503:physiopathology; D004748:Entamoeba histolytica / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections; D004760:Enterocolitis / Q000175:diagnosis / Q000382:microbiology* / Q000503:physiopathology; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D009093:Mucus; D011897:Random Allocation; D012475:Salmonella / Q000302:isolation & purification; D012760:Shigella / Q000302:isolation & purification