title: Sequence specific interaction of the photoactive drug hypericin depends on the structural arrangement and the stability of the structure containing its specific 5AG3 target: a resonance Raman spectroscopy study.
abstract: The resonance Raman spectra of three oligonucleotides with different lengths containing a specific 5'AG3' target doublet for hypericin - a potent antiretroviral and anticancer photoactive agent, and their 1:1 and 1:2 (oligonucleotide: hypericin) complexes are reported. It is shown that the structural arrangement of the oligonucleotides, their structural stability and the local structural arrangement around the 5'AG3' hypericin target, are the factors which determine the formation of a stable, specifically bounded DNA-hypericin complexes.
authors.affiliation: Department of Biophysics, P.J. Safárik University, Kosice, Slovakia.
authors.forename: E
authors.initials: E
authors.lastname: Kocisová
authors.forename: L
authors.initials: L
authors.lastname: Chinsky
authors.forename: P
authors.initials: P
authors.lastname: Miskovský
mesh_terms: D000873:Anthracenes; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000378:metabolism*; D013059:Spectrum Analysis, Raman; D013329:Structure-Activity Relationship
chemical_list: D000873:Anthracenes; D009838:Oligodeoxyribonucleotides; D011838:Radiation-Sensitizing Agents; D010569:Perylene; C004965:hypericin; D004247:DNA