A polymorphism in the CYP17 gene is associated with male breast cancer.
The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.
Young
I E
IE
University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK.
Kurian
K M
KM
Annink
C
C
Kunkler
I H
IH
Anderson
V A
VA
Cohen
B B
BB
Hooper
M L
ML
Wyllie
A H
AH
Steel
C M
CM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000728:Androgens / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology / Q000235:genetics; D018567:Breast Neoplasms, Male / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D004967:Estrogens / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics* / Q000378:metabolism
D000728:Androgens; D004967:Estrogens; D013254:Steroid 17-alpha-Hydroxylase