Acylcarnitine analogues as topical, microbicidal spermicides.
Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide.
Savle
P S
PS
Department of Chemistry, Virginia Tech, Blacksburg 24061-0212, USA.
Doncel
G F
GF
Bryant
S D
SD
Hubieki
M P
MP
Robinette
R G
RG
Gandour
R D
RD
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002331:Carnitine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013089:Spermatocidal Agents / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D013089:Spermatocidal Agents; C116917:acylcarnitine; D002331:Carnitine