[Content of fibroblasts, macrophages, granulocytes and lymphocytes in the connective tissue regenerate of the skin in wound healing as affected by noradrenaline, acetylcholine, propranolol and atropine].
Effects of acetylcholine, noradrenaline, atropine and propranolol on cell number in connective tissue regenerates of the skin in wound healing were studied in white rats. Noradrenaline causes the decrease of inflammatory reaction, fibroblast content in regenerate and basophilia of their cytoplasm. Acetylcholine conversely increases cell reaction, but slows down the re-modelling of connective tissue regenerate. The definite dynamic balance between catecholamine and acetylcholine systems of reparation processes regulation in wound healing is noted. This balance could deviate under external influences. The expression of various cellular element reaction to the dermal regenerate on adreno- and cholinotropic influences tends to change during wound healing.
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Department of Histology, A.A. Bogomolets National Medical University, Kiev, Ukraine.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002452:Cell Count / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects
D001285:Atropine; D011433:Propranolol; D000109:Acetylcholine; D009638:Norepinephrine