title: [A case of multiple bone metastases from advanced breast cancer effectively treated with pamidronate].
abstract: A 57-year-old woman, with bone, lymph node and skin metastases underwent mastectomy and extirpation of skin tumors. Chemoenderine-therapy was performed from the 15th day after operation, with a toremifene and CEF regimen consisting of cyclophosphamide, epirubicin and 5-fluorouracil. She had nausea and neurological symptoms from hypercalcemia (21.5 mg/dl) on the 28th day after operation. Her serum PTHrP level was found to be high at 214 pmol/l. We administered pamidronate in a dose of 45 mg biweekly, and she improved. The CEF regimen and pamidronate therapy was continued for 6 cycles and the regions of bone metastases were reduced on the bone scintography. Thereafter she has been administered pamidronate 30 mg/4 weeks as an outpatient with no further symptoms, and serum Ca and PTHrP have remained normal. In conclusion, pamidronate combined with chemotherapy can be a therapeutic option for not only hypercalcemia but also bone metastases of breast cancer.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Nakaguchi
authors.forename: J
authors.initials: J
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Shingai
authors.forename: T
authors.initials: T
authors.lastname: Azama
authors.forename: S
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumoto
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: S
authors.initials: S
authors.lastname: Okajima
authors.forename: F
authors.initials: F
authors.lastname: Sue
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D000077268:Pamidronate; D012878:Skin Neoplasms / Q000556:secondary
chemical_list: D004164:Diphosphonates; D015251:Epirubicin; D003520:Cyclophosphamide; D000077268:Pamidronate; D005472:Fluorouracil