[Significance of eosinophilic granulocytes in relation to allergy and aspirin intolerance in patients with sinusitis polyposa].
BACKGROUND
The development of nasal polyps might be influenced by different factors such as mucosal inflammation. Infiltration with eosinophils is a common finding, although in largely different quantitis.


METHODS
We investigated 58 patients suffering from nasal polyps who were assigned for endonasal sinus surgery based on endoscopic and CT findings. Out of these patients, 52% have already had sinus surgery and had recurrent polyps. All patients were subjected to both, allergy testing and a functional in vitro test for aspirin intolerance. During surgery, tissue samples were gained and send for histological examination with special respect to eosinophil infiltration.


RESULTS
Eosinophil infiltration was observed in 66% of all patients. 37 patients (64%) exhibited aspirin intolerance only, four (7%) had a positive allergy test only, in 9 patients (15%) both, allergy and aspirin intolerance were diagnosed. Allergy and aspirin intolerance were accompanied by eosinophil tissue infiltration. Eosinophil infiltration was more common and more severe if allergy and aspirin intolerance were found together compared with the tissue eosinophilia in patients with either one entity.


CONCLUSIONS
This study confirms the importance of eosinophil infiltration in the pathogenesis of severe or recurrent nasal polyps based on allergy and aspirin intolerance. A coincidance of allergy and aspirin intolerance was found in an unexpected high number of patients.
Kaldenbach
T
T
Hals-, Nasen-, Ohrenklinik und Poliklinik der Johannes Gutenberg-Universität Mainz.
Schäfer
D
D
Gosepath
J
J
Bittinger
F
F
Klimek
L
L
Mann
W J
WJ
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D004802:Eosinophilia / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology / Q000473:pathology; D009298:Nasal Polyps / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D009299:Nasal Provocation Tests; D012008:Recurrence; D012086:Reoperation; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D012307:Risk Factors; D012852:Sinusitis / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
D001241:Aspirin