Genetic control of cortical regionalization and connectivity.
Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distinct functional areas of the cerebral cortex in neonatal mice.
Rubenstein
J L
JL
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143-0984, USA. jlrr@cgl.ucsf.edu
Anderson
S
S
Shi
L
L
Miyashita-Lin
E
E
Bulfone
A
A
Hevner
R
R
D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000737:chemistry / Q000502:physiology; D015415:Biomarkers; D001933:Brain Stem / Q000166:cytology; D015820:Cadherins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins; D051797:Inhibitor of Differentiation Protein 2; D051379:Mice; D008815:Mice, Inbred Strains; D019579:Neocortex / Q000166:cytology* / Q000196:embryology* / Q000254:growth & development; D009419:Nerve Tissue Proteins / Q000235:genetics; D009434:Neural Pathways / Q000166:cytology* / Q000196:embryology* / Q000254:growth & development; D039942:Neuropilin-1; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D036141:Receptor, EphA7; D011956:Receptors, Cell Surface / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D044094:Receptors, Melatonin; D012097:Repressor Proteins; D013116:Spinal Cord / Q000166:cytology; D020825:T-Box Domain Proteins; D013788:Thalamus / Q000166:cytology; D014157:Transcription Factors; D051153:Wnt Proteins
D015415:Biomarkers; D015820:Cadherins; C504541:Cdh8 protein, mouse; D004268:DNA-Binding Proteins; D006023:Glycoproteins; C497452:Idb2 protein, mouse; D051797:Inhibitor of Differentiation Protein 2; D009419:Nerve Tissue Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D012097:Repressor Proteins; D020825:T-Box Domain Proteins; C492271:Tbr1 protein, mouse; D014157:Transcription Factors; D051153:Wnt Proteins; C095937:Wnt7b protein, mouse; D039942:Neuropilin-1; D020794:Receptor Protein-Tyrosine Kinases; D036141:Receptor, EphA7; C087310:K cadherin