Treatment of experimental burn wound sepsis by postburn immunization with polyvalent Pseudomonas antigen.
1. Vaccination with a new heptavalent Pseudomonas aeruginosa antigen was found to reduce mortality rates from experimental pseudomonal burn wound sepsis. 2. Adjunctive use of the heptavalent vaccine improved survival of animals with pseudomonal sepsis which were treated with topical antibiotics. 3. Elevated antibody titers following vaccination could be correlated with survival in this model.
Nance
F C
FC
Department of Surgery, Louisiana State University School of Medicine, New Orleans, USA.
Hines
J L
JL
Fulton
R E
RE
Bornside
G H
GH
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D002056:Burns / Q000628:therapy*; D005260:Female; D007114:Immunization; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D051381:Rats; D014946:Wound Infection / Q000628:therapy*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines