title: Translocation (X;1) associated with a nonpapillary carcinoma in a young woman: a new definition for an Xp11.2 RCC subtype.
abstract: We report a translocation (X;1)(p11.2;q21) associated with a nontubulopapillary renal cell carcinoma in a 23-year-old woman. To our knowledge this the first report of such an association. A review of the previously published cases of renal cell carcinoma with t(X;1) and its cytogenetic variants with Xp11.2 anomalies is included. The role of this karyotype abnormality as a clinical marker is discussed. The Xp11.2 abnormality could be a primary abnormality characterizing a particular type of RCC appearing in children and young adults of both sexes and in which the histological aspect is not specific.
authors.affiliation: Pathology and Cytogenetic Laboratory, Val de Grâce Hospital, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Désangles
authors.forename: P
authors.initials: P
authors.lastname: Camparo
authors.forename: C
authors.initials: C
authors.lastname: Fouet
authors.forename: A
authors.initials: A
authors.lastname: Houlgatte
authors.forename: M
authors.initials: M
authors.lastname: Arborio
mesh_terms: D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic; D014960:X Chromosome