title: Effect of HLA mismatches on the outcome of hematopoietic transplants.
abstract: Hematopoietic cell transplantation from unrelated volunteer donors for the treatment of hematological malignancy can be optimized by complete and precise matching for HLA class I and II alleles between the donor and recipient. Survival is improved when the donor and recipient are matched for HLA-A, -B, -C, -DRB, -DQB1 and -DPB1 alleles. The risks of clinically severe graft-versus-host disease, graft failure and mortality are increased in the presence of multilocus mismatching. These findings demonstrate that HLA allelic differences are biologically relevant in human transplantation.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA. epetersd@fhcrc.org
authors.forename: E W
authors.initials: EW
authors.lastname: Petersdorf
authors.forename: E M
authors.initials: EM
authors.lastname: Mickelson
authors.forename: C
authors.initials: C
authors.lastname: Anasetti
authors.forename: P J
authors.initials: PJ
authors.lastname: Martin
authors.forename: A E
authors.initials: AE
authors.lastname: Woolfrey
authors.forename: J A
authors.initials: JA
authors.lastname: Hansen
mesh_terms: D006084:Graft Rejection; D006085:Graft Survival; D006402:Hematologic Diseases / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans