Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo.
Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF(70-80)) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.
Roach
D R
DR
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, South Australia, Australia.
Briscoe
H
H
Baumgart
K
K
Rathjen
D A
DA
Britton
W J
WJ
D000818:Animals; D005260:Female; D006099:Granuloma / Q000382:microbiology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000187:drug effects*; D010446:Peptide Fragments / Q000627:therapeutic use*; D014376:Tuberculosis / Q000382:microbiology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha