title: Effector pathways in immune mediated central nervous system demyelination.
abstract: Multiple sclerosis is generally regarded to be a primarily T-cell driven disease. Recent evidence has refocused interest on antibodies. Adhesion molecules, matrix metalloproteinases, chemokines and cytokines, and nitric oxide and oxygen metabolites all participate in the amplification and effector stages of the disease.
authors.affiliation: Department of Neurology, Karl-Franzens Universität Graz, Austria. bc.kieseier@kfunigraz.ac.at
authors.forename: B C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: M K
authors.initials: MK
authors.lastname: Storch
authors.forename: J J
authors.initials: JJ
authors.lastname: Archelos
authors.forename: G
authors.initials: G
authors.lastname: Martino
authors.forename: H P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D018925:Chemokines / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D008666:Metalloendopeptidases / Q000276:immunology; D009103:Multiple Sclerosis / Q000201:enzymology / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D008666:Metalloendopeptidases