The biotransformation of ent-kaur-16-en-19-oic acid by Rhizopus stolonifer.
Microbial transformation of ent-kaur-16-en-19-oic acid was carried out with R. stolonifer. After seven days of incubation, two metabolites, ent-7 alpha-hydroxy-kaur-16-en-19-oic acid and ent-12 beta-hydroxy-kaur-9(11),16-dien-19-oic acid, were isolated as a result of hydroxylation and hydroxylation/dehydrogenation, respectively. Incubation for 15 days also afforded ent-16 beta,17-dihydroxy-kauran-19-oic acid. The metabolites were identified by spectroscopic methods.
Silva
E A
EA
Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Takahashi
J A
JA
Boaventura
M A
MA
Oliveira
A B
AB
D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000493:pharmacokinetics; D015394:Molecular Structure; D012233:Rhizopus / Q000378:metabolism*; D013057:Spectrum Analysis
D004224:Diterpenes; C014341:argyrophilic acid