title: Pathogenic light chains and the B-cell repertoire.
abstract: Dysfunctional immunoglobulins (Igs) that are prone to aggregation are unavoidably generated by the diverse repertoire of B cells. Here, Fred Stevens and Yair Argon analyse the patterns of mutations that lead to pathological Igs, account for non-random mutations in human Ig sequences and suggest the exertion of selective forces, which contribute to determining and limiting the Ig repertoire.
authors.affiliation: Biosciences Division, Argonne National Laboratory, Argonne, IL, USA.
authors.forename: F J
authors.initials: FJ
authors.lastname: Stevens
authors.forename: Y
authors.initials: Y
authors.lastname: Argon
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000737:chemistry / Q000235:genetics*; D008958:Models, Molecular; D009154:Mutation; D010265:Paraproteinemias / Q000235:genetics / Q000276:immunology; D017510:Protein Folding
chemical_list: D007147:Immunoglobulin Light Chains