Cardiovascular and thermoregulatory responses to vasotocin and angiotensin II in the pigeon.
The cardiovascular and thermoregulatory effects of intrahypothalamically (preoptic/anterior hypothalamus) and intravenously injected arginine vasotocin (AVT) and [Val5]angiotensin II (ANG II) were measured at 2 degrees C in the pigeon (Columba livia). In addition, the effects of intrahypothalamic and intravenous injections of AVT on respiratory rates were measured at 10-15 degrees C. Intrahypothalamic and intravenous AVT (500 ng and 20 micrograms/kg, respectively) reduced shivering and body temperature but had no effects on blood pressure, heart rate or respiratory rate. Intrahypothalamic (500 ng and 1 microgram) and intravenous (3 micrograms/kg) ANG II elevated blood pressure. If the blood pressure increased slowly, the shivering and body temperature also increased, whereas a rapid rise in blood pressure inhibited shivering and lowered body temperature. Intravenous ANG II produced tachycardia but intrahypothalamic ANG II did not affect the heart rate.
Hassinen
E
E
Department of Biology, University of Oulu, Finland.
Pyörnilä
A
A
Hissa
R
R
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D010856:Columbidae / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007275:Injections, Intravenous; D008297:Male; D008845:Microinjections; D012768:Shivering / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014668:Vasotocin / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D014668:Vasotocin