title: Multiple minute digitate hyperkeratoses report of two cases with an updated review and proposal for a new classification.
abstract: Multiple minute digitate hyperkeratoses (MMDH) is a relatively rarely described disorder of keratinization of unknown origin. We noticed that MMDH has been reported in the literature under a variety of synonyms. We observed two patients with MMDH and reviewed the literature. We concluded that MMDH is a skin disorder which can be properly separated from other disorders of keratinization and classified as a distinct entity. Two forms of MMDH exist: MMDH of early onset and MMDH of late onset. Both forms are described occurring in a widespread and in a localized pattern. The early onset form may be hereditary, the late onset form may present as part of a paraneoplastic syndrome.
authors.affiliation: Department of Dermatology, St. Antonius, Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, the Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Ramselaar
authors.forename: J
authors.initials: J
authors.lastname: Toonstra
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003879:Dermatologic Agents / Q000008:administration & dosage; D004817:Epidermis / Q000473:pathology*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000145:classification* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D003879:Dermatologic Agents