Losartan-induced angioedema.
OBJECTIVE
To report a case of angioedema associated with losartan administration.


METHODS
A 45-year-old white man with a history of hypertension and gout was treated with losartan/hydrochlorothiazide, allopurinol, and colchicine. The patient experienced two episodes of angioedema within a 10-hour period. On both occasions the symptoms resolved after treatment.


CONCLUSIONS
Angiotensin-converting enzyme (ACE) inhibitors are associated with a relatively high incidence of angioedema. The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown. The patient reported in this case differs significantly from the two cases reported in the literature because he had normal renal function, no previous exposure to ACE inhibitors, the reaction was of late onset, and the symptoms recurred.


CONCLUSIONS
This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.
Rivera
J O
JO
Cooperative Pharmacy Program, University of Texas Austin, USA. JRivera@utep.edu
D000799:Angioedema / Q000139:chemically induced* / Q000473:pathology; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D019808:Losartan