The high-grade match program of the South-Eastern Organ Procurement Foundation: status at four years.
In summary, the HGM program is a voluntary, multicenter, prospective study of the SEOPF that is open to all transplant centers. The program extends mandatory sharing beyond the UNOS zero-antigen mismatch obligation, and uses preliminary crossmatching via ROP trays to try to facilitate transplantation of the highly sensitized patient. The program encompasses less than 7% of the cadaver kidney transplant activity of the participating centers, so it does not impact the majority of recipients. After 49 months of operation, it has significantly improved access to transplantation for blood group O patients, patients awaiting re-grafts, and those who are highly sensitized (PRA > or = 40%). Additionally, 92% of the HGM recipients have received an allograft with 2 or less antigens mismatched. Enrollment will continue until there is sufficient power to test the null hypothesis of equality of HGM and non-HGM transplants.
Adams
P L
PL
Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Thacker
L R
LR
Blanton
J W
JW
McCune
T R
TR
D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D015144:Southeastern United States; D014019:Tissue Donors / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000458:organization & administration* / Q000706:statistics & numerical data
D000017:ABO Blood-Group System