Myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML) and chronic myeloproliferative disorder (CMPD) in cats.
Histological, enzyme histochemical and ultrastructural findings in three cases of feline bone marrow neoplasia are described. The following changes were observed: in myelodysplastic syndrome (MDS), a low medullary blast count, strongly atypical (micromegakaryocytic) proliferative megakaryocytopoiesis, hypoplastic erythrocytopoiesis with impairment of differentiation, multifocal extravasation and lymphoid aggregates; in acute myeloid leukaemia (AML), medullary proliferation of undifferentiated cell types; in chronic myeloIproliferative disorder (CMPD), trilinear medullary proliferation with complete cellular maturation, osteomyelosclerosis and extramedullary haemopoiesis. In two cases (MDS, AML), ultrastructural demonstration of C-type virus particles (feline leukaemia virus) suggested a viral aetiology.
Breuer
W
W
Institute of Veterinary Pathology, University of Munich, Veterinaerstrasse 13, Munich, D-80539, Germany.
Hermanns
W
W
Thiele
J
J
D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure / Q000821:virology; D002371:Cat Diseases / Q000473:pathology* / Q000821:virology; D002415:Cats; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017988:Gammaretrovirus / Q000302:isolation & purification; D007951:Leukemia, Myeloid / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008533:Megakaryocytes / Q000473:pathology / Q000648:ultrastructure; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D009196:Myeloproliferative Disorders / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D013154:Spleen / Q000473:pathology
D000914:Antibodies, Viral