title: How do antidepressants work? Prospects for genetic analysis of drug mechanisms.
authors.affiliation: Department of Biology, University of California, San Diego, La Jolla 92093-0349, USA.
authors.forename: W R
authors.initials: WR
authors.lastname: Schafer
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism; D015195:Drug Design; D004351:Drug Resistance / Q000235:genetics; D005473:Fluoxetine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D008954:Models, Biological; D009419:Nerve Tissue Proteins; D010597:Pharmacogenetics; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins; D015398:Signal Transduction
chemical_list: D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D005473:Fluoxetine; D012701:Serotonin