title: A prospective comparison of magnetic resonance cholangiopancreatography with endoscopic retrograde cholangiopancreatography in the evaluation of patients with suspected biliary tract disease.
abstract: OBJECTIVE
  To determine the diagnostic accuracy of magnetic resonance cholangiopancreatography (MRCP) compared with direct cholangiography in the detection of biliary tract disease.
  
  
  METHODS
  MRCP was performed in 100 patients in whom direct cholangiographic correlation (ERCP, n = 98; PTC, n = 9; intraoperative cholangiography, n = 3) was available for comparison. The MRCP examinations were performed using a two-dimensional multi-slice, fast spin echo (FSE) technique and a local surface coil. The diagnoses at direct cholangiography were choledocholithiasis in 30 patients, benign and malignant strictures in 28 patients and normal bile ducts in 42 patients. The nature of the strictures (benign, n = 2; tumour, n = 18; lymphnode recurrence, n = 3; unknown histology, n = 5) was determined by one or more of the following procedures: surgery (n = 8), biopsy (n = 15), cytology (n = 6) and cross-sectional imaging/follow-up findings (n = 3).
  
  
  RESULTS
  MRCP diagnosed choledocholithiasis with a sensitivity of 93%, specificity of 99% and accuracy of 97 %. It resulted in two false-negative and one false-positive findings when compared with direct cholangiography. MRCP accurately diagnosed the presence and level of strictures in all patients. The overall sensitivity, specificity and accuracy of MRCP in the detection of bile duct lesions were 97%, 98% and 97%, respectively.
  
  
  CONCLUSIONS
  MRCP has a high diagnostic accuracy when compared with direct cholangiography in the detection of bile duct disease.
authors.affiliation: The Department of Radiology, Beaumont Hospital and The Royal College of Surgeons in Ireland, Dublin.
authors.forename: J C
authors.initials: JC
authors.lastname: Varghese
authors.forename: M A
authors.initials: MA
authors.lastname: Farrell
authors.forename: G
authors.initials: G
authors.lastname: Courtney
authors.forename: H
authors.initials: H
authors.lastname: Osborne
authors.forename: F E
authors.initials: FE
authors.lastname: Murray
authors.forename: M J
authors.initials: MJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001649:Bile Duct Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D001660:Biliary Tract Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D042882:Gallstones / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method