Large cell calcifying Sertoli cell tumor of the testis: a clinicopathological, immunohistochemical, and ultrastructural study of two cases.
Large cell calcifying Sertoli cell tumor of the testis (LCCSCT) is a rare tumor that is usually benign and multifocal. It may be associated with hereditary endocrine anomalies such as Carney's and Peutz-Jeghers syndromes. Malignant forms are exceptional. Two cases of LCCSCT, one malignant and one benign are described. Both were composed of cords and trabeculae of large polygonal cells embedded in a myxoid and fibrous stroma with areas of calcification. The malignant tumor showed nuclear atypia, necrosis, and abundant mitoses. The cells were positive for vimentin and S-100 protein, and the intercellular space for laminin and collagen type IV. By electron microscopy, nucleolonemas and multilayered basal lamina were seen. The benign tumor was positive for vimentin and S-100 protein, and ultrastructurally showed less basal lamina.
Cano-Valdez
A M
AM
Department of Surgical Pathology, Instituto Nacional de Cancerología, México, DF.
Chanona-Vilchis
J
J
Domínguez-Malagón
H
H
D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D002114:Calcinosis / Q000473:pathology*; D002466:Cell Nucleolus / Q000648:ultrastructure; D003094:Collagen / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis; D008297:Male; D009418:S100 Proteins / Q000032:analysis; D012707:Sertoli Cell Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D013736:Testicular Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
D007797:Laminin; D009418:S100 Proteins; D014746:Vimentin; D003094:Collagen