Note: caution in use of empirical equations for pharmacodynamic indirect response models.
An empirical equation was recently proposed and used to characterize inhibitory drug effects on production of an endogenous substance. The limitations of this empirical equation are described utilizing mathematical equations and simulations based on the exact differential equation for Indirect Response Model I. The latter is preferable for fitting data using indirect response models.
Krzyzanski
W
W
Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14260, USA.
Jusko
W J
WJ
D003627:Data Interpretation, Statistical; D008954:Models, Biological; D010599:Pharmacokinetics