title: Apoptosis. Molecules and mechanisms.
abstract: This review of the molecules and pathways involved in programmed cell death (apoptosis) discriminates triggers of apoptosis (e.g. chemotherapy, radiation, Fas ligation), modulators of apoptosis (e.g. Bcl-2 family members, Bcl-2 interacting proteins, Apafs, IAPs, and Fas/FasL modulators including FLICE and FLIPs), effectors (caspases 1-13) and cleavage substrates (e.g. PARP). Special consideration is given to the structure-function relationship of Bcl-2 family members and to their post-transcriptional modification. Brief references are made to the role of apoptotic pathway in leukemias and lymphomas and to strategies of modulating apoptotic pathways.
authors.affiliation: Department of Molecular Hematology and Therapy, M.D. Anderson Cancer Center, University of Texas, Houston, USA.
authors.forename: M
authors.initials: M
authors.lastname: Konopleva
authors.forename: S
authors.initials: S
authors.lastname: Zhao
authors.forename: Z
authors.initials: Z
authors.lastname: Xie
authors.forename: H
authors.initials: H
authors.lastname: Segall
authors.forename: A
authors.initials: A
authors.lastname: Younes
authors.forename: D F
authors.initials: DF
authors.lastname: Claxton
authors.forename: Z
authors.initials: Z
authors.lastname: Estrov
authors.forename: S M
authors.initials: SM
authors.lastname: Kornblau
authors.forename: M
authors.initials: M
authors.lastname: Andreeff
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D002352:Carrier Proteins / Q000378:metabolism; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000378:metabolism; D053222:Fas Ligand Protein; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007938:Leukemia / Q000473:pathology* / Q000503:physiopathology; D008223:Lymphoma / Q000473:pathology* / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D019014:fas Receptor / Q000502:physiology
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; C506386:CFLAR protein, human; D002352:Carrier Proteins; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases