The effects of calcium channel blocker and thyrotropin releasing hormone on acute necrotizing pancreatitis in rats.
The main purpose of this study was to investigate the influence of nimodipine, a calcium channel blocker (CCB) and thyroid-releasing hormone (TRH) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. CCB decreased blood pressure in rats in the control and pancreatitis groups. TRH corrected this decrease. CCB alone had no effect on PO2 serum amylase activity, calcium concentration, liver transaminases, lactate dehydrogenase or the degree of pancreatic damage, except for the serum concentration of creatinine. CCB+TRH reduced the concentrations of serum urea and creatinine, the degree of pancreatic damage, and increased PO2 and serum calcium concentration. CCB and CCB+TRH had no effect on pancreatic myeloperoxidase activity. CCB alone had no effect on the course of ANP, but CCB+TRH had beneficial effects on the course of the ANP and various systems.
Alhan
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E
Department of Surgery, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.
Küçüktülü
U
U
Erçin
C
C
Efe
H
H
Al
S
S
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002108:Ceruletide; D006002:Glycodeoxycholic Acid; D007262:Infusions, Intravenous; D008297:Male; D008991:Monitoring, Physiologic; D009553:Nimodipine / Q000627:therapeutic use*; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D009195:Peroxidase / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D006002:Glycodeoxycholic Acid; D009553:Nimodipine; D013973:Thyrotropin-Releasing Hormone; D002108:Ceruletide; D009195:Peroxidase