title: Allelic exclusion in B and T lymphopoiesis.
abstract: The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.
authors.affiliation: Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, The Hebrew University, Hadassah Medical School, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Bergman
mesh_terms: D000483:Alleles; D000818:Animals; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics*; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D006410:Hematopoiesis; D006801:Humans; D008745:Methylation; D051379:Mice; D011948:Receptors, Antigen, T-Cell
chemical_list: D011948:Receptors, Antigen, T-Cell