title: Evaluation and treatment of weight loss in adults with HIV disease.
abstract: Weight loss late in the course of human immunodeficiency virus (HIV) disease is common and often multifactorial. Increased energy expenditure in response to opportunistic disease, as well as to HIV infection itself, can lead to protein-calorie malnutrition similar to that observed in starvation. Weight loss of as little as 5 percent in patients with HIV infection is associated with an increased risk of disease progression. Loss of body cell mass carries a particularly poor prognosis, and aggressive measures should be taken to stop such depletion. Patients exhibiting unexpected weight loss should be carefully examined to exclude decreased food intake, malabsorption, occult infection or neoplasm as the etiology of the weight loss. Early aggressive treatment of HIV disease and underlying opportunistic pathology, along with adequate pharmacologic, hormonal, nutritional and physical therapy, can often restore normal weight and body composition.
authors.affiliation: Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87131, USA.
authors.forename: B
authors.initials: B
authors.lastname: Williams
authors.forename: D
authors.initials: D
authors.lastname: Waters
authors.forename: K
authors.initials: K
authors.lastname: Parker
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications; D000328:Adult; D000465:Algorithms; D000932:Antiemetics / Q000627:therapeutic use; D019167:Appetite Stimulants / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005767:Gastrointestinal Diseases / Q000150:complications; D019247:HIV Wasting Syndrome / Q000175:diagnosis* / Q000178:diet therapy / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D010353:Patient Education as Topic; D012307:Risk Factors; D013664:Teaching Materials; D015431:Weight Loss
chemical_list: D000932:Antiemetics; D019167:Appetite Stimulants