Notch around the clock.
The establishment of a segmental pattern within the vertebrate body plan is achieved during embryogenesis by the somitogenesis process. Two molecular systems have been implicated in this phenomenon: a molecular clock linked to vertebrate segmentation and the Notch signalling pathway. Rhythmic expression of the Lunatic Fringe gene in the presomitic mesoderm has now provided a link between these two systems.
Pourquié
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Laboratoire de Génétique et de Physiologie du Développement (LGPD) CNRS-INSERM-Université de la Méditerranée - AP de Marseille Campus de Luminy, Case 907, 13288, Marseille,France. pourquie@ibdm.univ-mrs.fr
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D016695:Glycosyltransferases; D008565:Membrane Proteins / Q000378:metabolism*; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D011506:Proteins / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D051880:Receptors, Notch; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D014981:Xenopus; D029867:Xenopus Proteins
D051792:Basic Helix-Loop-Helix Proteins; D016695:Glycosyltransferases; D008565:Membrane Proteins; D011506:Proteins; D020794:Receptor Protein-Tyrosine Kinases; D051880:Receptors, Notch; D014157:Transcription Factors; D029867:Xenopus Proteins; C101538:Mesp1 protein, mouse; C107407:Mesp2 protein, mouse; C100015:LFNG protein, Xenopus; C498392:Lfng protein, mouse