title: Novel polymorphism in the 5'-untranslated region of the interleukin-4 gene.
abstract: We found a novel polymorphism C/T change at position -34 counting from the first ATG codon, of the interleukin-4 (IL-4) gene, located between the TATA box and the first ATG on exon 1. The allelic frequency of this C/T polymorphism in 64 independent Japanese samples was 0.37:0.63. In addition, PCR-restriction fragment length polymorphism analysis revealed that the -34T/T polymorphism was always associated with -590T/T, a known polymorphism that increases IL-4 transcriptional activity.
authors.affiliation: Department of Pediatrics, Kyushu University, Fukuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takabayashi
authors.forename: K
authors.initials: K
authors.lastname: Ihara
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Kusuhara
authors.forename: S
authors.initials: S
authors.lastname: Nishima
authors.forename: T
authors.initials: T
authors.lastname: Hara
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D003062:Codon / Q000235:genetics; D005091:Exons; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D007564:Japan; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D020121:5' Untranslated Regions; D003062:Codon; D015847:Interleukin-4