title: A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images.
abstract: An optimized dynamic gradient echo sequence with two echoes is used to obtain data that can be analyzed with indicator dilution theory as well as with pharmacokinetic theory. Taking advantage of the simultaneity of T(*)(2) and T(1) information, both theories can be employed and merged to interpret consistently the observed effects of the redistribution of a contrast agent (gadopentetate dimeglumine) into the tissue from first pass onward. The regional cerebral blood volume (rCBV) and the exchange rate of the contrast agent between the vascular and the interstitial space through the blood-brain barrier are analyzed for each pixel in a two-step algorithm. Two values for rCBV are obtained with different weighting for the microvascular fraction of the blood volume. Because the analysis, called PELEAKAN, is capable of separating effects related to perfusion (through intravascular blood volume) and to leakage in places where the blood-brain barrier is damaged, it is an appropriate tool for evaluating these parameters in brain tumors, and we show clinical examples of this analysis in brain tumor patients.
authors.affiliation: Groupe de Recherche en Imagerie et Spectroscopie Nucléaires, 69008 Lyon, France. emmanuel.barbier@lsgrisn1.univ-lyon1.fr
authors.forename: E L
authors.initials: EL
authors.lastname: Barbier
authors.forename: J A
authors.initials: JA
authors.lastname: den Boer
authors.forename: A R
authors.initials: AR
authors.lastname: Peters
authors.forename: A R
authors.initials: AR
authors.lastname: Rozeboom
authors.forename: J
authors.initials: J
authors.lastname: Sau
authors.forename: A
authors.initials: A
authors.lastname: Bonmartin
mesh_terms: D000328:Adult; D001810:Blood Volume; D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010539:Permeability
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA