Interleukin-10 in Epstein-Barr virus-associated post-transplant lymphomas.
We used enzyme-linked immunosorbent assays (ELISA) to investigate the presence of interleukin-10 (IL-10) in the serum of patients developing post-transplant lymphomas. Serum IL-10 was detected in 14 out of 19 cases with a lymphoma or Hodgkin's disease, with higher values being observed in patients who had developed a lymphoma within the first few months post-transplantation, and who had an aggressive form of the disease. Eleven out of the 14 patients in whom IL-10 was detected had Epstein Barr virus-positive tumors. And 11 out of 14 patients died of lymphomas. In most of the patients who had detectable IL-10 at the time of diagnosis of the lymphoma, the IL-10 had not been present previously, but it was found in the serum of 7 out of 9 dialysis patients, and in 8 out of 17 stable transplant patients. We conclude that IL-10 plays a role in the development of the more severe forms of post-transplant lymphomas, and may be secreted by tumor cells. However. data from patients with chronic renal failure or patients undergoing immunosuppressive therapy must be treated with caution.
Garnier
J L
JL
Department of Nephrology, Transplantation and Clinical Immunology, Hôpital Edouard Herriot, Lyon, France. geti@lyon151.inserm.fr
Blanc-Brunat
N
N
Vivier
G
G
Rousset
F
F
Touraine
J L
JL
D002051:Burkitt Lymphoma / Q000097:blood* / Q000209:etiology / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016753:Interleukin-10 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D011379:Prognosis; D014412:Tumor Virus Infections / Q000097:blood / Q000209:etiology
D016753:Interleukin-10