title: [The effect of 5-HT 2 antagonist for urinary frequency symptom on diabetes mellitus patients].
abstract: 17 cases of patients with diabetes mellitus who had urinary frequency symptom for which anti-cholinergic agents proved ineffective were given Sarpogrelate Hydrochloride (Anplag), a selective 5-HT 2 receptor antagonist. Efficacy was judged using IPSS and QOL scores after 2 weeks medications, these showed that all cases had improved their urinary frequency during the days as well as the night. This was especially true for the QOL score. One time urinary volume markedly increased, but there was no statistical significance after medication in maximum flow rate and residual urine. At the same time, a separate group of 14 mainly BPH cases did not improve entirely. It is believed that reaction in the detrusor muscle with hyperreflexia of diabetes mellitus patients can reach 5-HT, and its reaction is believed to reach via the 5-HT 2 receptor. This paper is a first clinical report of making use of 5-HT 2 antagonist as hyperactive detrusor on diabetes mellitus patients.
authors.affiliation: Nihon University School of Medicine, Surugadai Nihon University Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
authors.forename: M
authors.initials: M
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Sugimoto
authors.forename: T
authors.initials: T
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Fuse
authors.forename: N
authors.initials: N
authors.lastname: Kawata
authors.forename: H
authors.initials: H
authors.lastname: Hirakata
authors.forename: H
authors.initials: H
authors.lastname: Hosokawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D013386:Succinates / Q000627:therapeutic use*; D014555:Urination Disorders / Q000188:drug therapy* / Q000209:etiology
chemical_list: D012702:Serotonin Antagonists; D013386:Succinates; C064294:sarpogrelate