title: P'-extended alpha-ketoamide inhibitors of proteasome.
abstract: A series of potent P'-extended alpha-ketoamide inhibitors of chymotrypsin-like activity of proteasome is described.
authors.affiliation: Department of Chemistry, Cephalon Inc., West Chester, PA 19380-4245, USA.
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: D
authors.initials: D
authors.lastname: Dunn
authors.forename: S
authors.initials: S
authors.lastname: Mallya
authors.forename: M A
authors.initials: MA
authors.lastname: Ator
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000187:drug effects*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000187:drug effects*; D046988:Proteasome Endopeptidase Complex; D013329:Structure-Activity Relationship
chemical_list: D015853:Cysteine Proteinase Inhibitors; D009097:Multienzyme Complexes; D001120:Arginine; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex