title: Intraoperative high dose fentanyl induces postoperative fentanyl tolerance.
abstract: OBJECTIVE
  In a randomized, double-blind clinical trial, we compared the postoperative analgesic effect and dose consumption of fentanyl after intraoperative high dose and low dose fentanyl administration.
  
  
  METHODS
  Sixty ASA class I to II female patients undergoing total abdominal hysterectomy (TAH), were randomly allocated to receive either 1 microg x kg(-1) (low dose group, n = 30) or 15 microg x kg(-1) (high dose group, n = 30) fentanyl during induction of anesthesia. Anesthesia depth was maintained with inhalation of halothane in the low dose group, or combined with 100 microg x hr(-1) fentanyl i.v. in the high dose group. Postoperative pain was treated with an intravenous patient-controlled analgesia system and was assessed with a visual analog pain score at rest.
  
  
  RESULTS
  Patients in the high dose group had higher pain intensity at four and eight hours postoperatively, more fentanyl consumption and a greater incidence of emesis in the postoperative period of 16 hr than those in the low dose group (P < 0.05). Heart rate, blood pressure, and respiratory rate were similar between the two groups.
  
  
  CONCLUSIONS
  Our results suggest that acute fentanyl tolerance develops after administration of high dose fentanyl during surgery and, consequently, results in a higher postoperative pain intensity and greater fentanyl consumption.
authors.affiliation: Department of Anesthesia, Veterans General Hospital-Kaohsiung, Taiwan, ROC. yychia@isca.vghks.gov.tw
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chia
authors.forename: K
authors.initials: K
authors.lastname: Liu
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: M C
authors.initials: MC
authors.lastname: Kuo
authors.forename: S T
authors.initials: ST
authors.lastname: Ho
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D001784:Blood Gas Analysis; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007044:Hysterectomy; D007432:Intraoperative Period; D008875:Middle Aged; D010147:Pain Measurement / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D005283:Fentanyl