title: Concordance between dobutamine Doppler tissue imaging echocardiography and rest reinjection thallium-201 tomography in dysfunctional hypoperfused myocardium.
abstract: OBJECTIVE
  To evaluate the efficiency of the new technique colour Doppler tissue imaging (DTI) by studying the concordance between dobutamine DTI, standard grey scale echocardiography (SE), and rest-reinjection TI-201 tomography (TI) in dysfunctional myocardium.
  
  
  METHODS
  23 patients with chronic wall motion abnormalities and proven coronary artery disease (> 70% diameter stenosis of at least one major coronary artery at angiogram).
  
  
  METHODS
  The contractile reserve and the resting perfusion characteristics of dysfunctional myocardial segments were assessed with low dose dobutamine SE and/or DTI (2.5 up to 20 gamma/kg/min) and TI on a semiquantitative basis. The DTI or SE data were separately compared with TI, on the basis of a 13 segment ventricular model. The resulting score of combined DTI and SE was also compared with TI. Finally the results obtained from DTI were compared with SE.
  
  
  RESULTS
  A total of 142 severely hypokinetic or akinetic segments were visualised. The viability study was feasible in 127 (89%) and 121 (85%) segments with DTI and SE, respectively. TI detected viability more frequently than DTI (84 v 61, p < 0.001) and SE (80 v 50, p < 0.001). However, as many viable segments were detected with combined DTI and SE as with TI (78 v 84, NS). The kappa values between TI and SE, DTI or combined SE and DTI were 0.38, 0.45, and 0.57, respectively, and increased to 0.52 and 0.76, respectively, for SE and DTI versus TI when mid-anterior and mid-inferior segments only were considered. The kappa value between SE and DTI was 0.34.
  
  
  CONCLUSIONS
  DTI is a helpful adjunct to SE, when using low dose dobutamine. This combination revealed as many viable segments as TI and showed a better agreement than DTI or SE alone for the assessment of myocardial viable segments evidenced by TI.
authors.affiliation: Department of Cardiology, University Hospital Bicêtre, 78 rue du Général Leclerc, 94 270 Le Kremlin Bicêtre, France. fahic.larrazet@bct.ap-hop.paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Larrazet
authors.forename: D
authors.initials: D
authors.lastname: Pellerin
authors.forename: D
authors.initials: D
authors.lastname: Daou
authors.forename: S
authors.initials: S
authors.lastname: Witchitz
authors.forename: C
authors.initials: C
authors.lastname: Fournier
authors.forename: A
authors.initials: A
authors.lastname: Prigent
authors.forename: C
authors.initials: C
authors.lastname: Veyrat
mesh_terms: D000318:Adrenergic beta-Agonists; D016009:Chi-Square Distribution; D004280:Dobutamine; D004452:Echocardiography; D018618:Echocardiography, Doppler, Color; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000000981:diagnostic imaging; D015588:Observer Variation; D011237:Predictive Value of Tests; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000318:Adrenergic beta-Agonists; D013794:Thallium Radioisotopes; D004280:Dobutamine