title: [Clinical and experimental rationale of policatan administration in upper respiratory tract inflammation].
abstract: Experimental and clinical trials of policatan in ENT inflammation have established that maximal antiinflammatory effect of the drug manifests in experimental serotonin, histamine and corragenin edema, less pronounced--in formaline-induced edema. The drug accelerated healing of infected burn ulcer in rabbit nose by 37%. This may be explained not only antiinflammatory effect of policatan, but also by stimulation of macrophage phagocytosis and bacteriostatic potential. Policatan proved effective in acute and chronic maxillary sinusitis, chronic frontal sinusitis and rhinitis, chronic hyperplastic maxilloethmoiditis. The drug reduced contamination with pathogenic and opportunistic microflora and reestablished saprophyte microflora.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: N K
authors.initials: NK
authors.lastname: Sanzharovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Ostrovskiĭ
authors.forename: L A
authors.initials: LA
authors.lastname: Martynova
authors.forename: E S
authors.initials: ES
authors.lastname: Temkin
authors.forename: L S
authors.initials: LS
authors.lastname: Mazanova
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004333:Drug Administration Routes; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015636:Magnesium Chloride / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008875:Middle Aged; D008903:Minerals; D011817:Rabbits; D051381:Rats; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D008903:Minerals; C072517:bishofit; D015636:Magnesium Chloride