Evaluation of regional liver function by gadolinium-EOB-DTPA-enhanced MR imaging.
We evaluated the role of magnetic resonance (MR) imaging with gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA), in estimating regional liver function in a rat ischemia-reperfusion model. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 min (I-90 group). The ischemic lobes in the I-60 and I-90 groups was clearly visualized as a high intensity area in the T1 images at late phase of Gd-EOB-DTPA enhancement, Moreover, the T1/2 of signal intensity in ischemic lobes significantly correlated with the duration of vascular clamping. We also observed significant correlation between T1/2 and ATP concentration in the liver tissue (r = -0.719, P = 0.04). Our results indicate that MR imaging with Gd-EOB-DTPA is useful for evaluation of regional liver function in rats.
Shimizu
J
J
Second Department of Surgery, Osaka University Medical School, Yamadaoka, Suita City, Japan.
Dono
K
K
Gotoh
M
M
Hasuike
Y
Y
Kim
T
T
Murakami
T
T
Sakon
M
M
Umeshita
K
K
Nagano
H
H
Nakamori
S
S
Kato
N
N
Miyazawa
T
T
Nakamura
H
H
Monden
M
M
D000818:Animals; D003287:Contrast Media; D019786:Gadolinium DTPA; D007089:Image Enhancement; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000502:physiology; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*
D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA