[Changes in the behavior and EEG of rats administered penicillin and a physiological solution into the amygdalar basal nuclei].
Three weeks after implantation of the electrodes for EEG recording, hyperactivation of the basal nucleus of rat's amygdala was produced by a local injection of penicillin (0.5 mcl, 1% solution). Saline injection of the same volume served as control. The hyperactivation of the amygdala resulted in a long-lasting (at least for 3 weeks) increase in the locomotor activity against the background and deficit in exploratory behavior and rise of the level of anxiety and fear. The behavioral changes were accompanied by a long-term disruption of the hippocampal theta rhythm, appearance and slowing of the immobility-related high-voltage spindles, and increase in the EEG dominant frequency in the state of emotional tension. Saline injection led to a short-time (up to 1 week) decrease in locomotor and exploratory activity and increase in anxiety. These phenomena were accompanied by a short-time disruption of the theta rhythm and appearance of the 10-13-Hz oscillations characteristic for the state of emotional tension.
Pankova
N B
NB
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Kryzhanovskiĭ
G N
GN
Kuznetsov
Iu B
IuB
Latanov
A V
AV
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003292:Convulsants / Q000008:administration & dosage* / Q000494:pharmacology; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods / Q000706:statistics & numerical data; D005583:Fourier Analysis; D008297:Male; D010400:Penicillin G / Q000008:administration & dosage* / Q000494:pharmacology; D010406:Penicillins / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013997:Time Factors
D003292:Convulsants; D010406:Penicillins; D012996:Solutions; D010400:Penicillin G