Drug discrimination under a concurrent fixed-ratio fixed-ratio schedule.
Pigeons were trained to discriminate 5.0 mg/kg pentobarbital from saline under a two-key concurrent fixed-ratio 10 fixed-ratio 40 schedule of food presentation, in which the fixed-ratio component with the lower response requirement was programmed to reinforce responding on one key after drug administration (pentobarbital-biased key) and on the other key after saline administration (saline-biased key). After responding stabilized, pigeons averaged 98% of their responses on the pentobarbital-biased key during training sessions preceded by pentobarbital, and they averaged 90% of their responses on the saline-biased key during training sessions preceded by saline. In test sessions preceded by doses of pentobarbital, chlordiazepoxide, or ethanol, pigeons switched from responding on the saline-biased key at low doses to responding on the pentobarbital-biased key at higher doses (the dose-response curve was quantal). High doses of phencyclidine produced responding on both keys, whereas pigeons responded almost exclusively on the saline-biased key after all doses of methamphetamine. These and previous experiments using concurrent reinforcement schedules to study drug discrimination illustrate that the schedule of reinforcement is an important determinant of the shape of dose-effect curves in drug-discrimination experiments.
McMillan
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Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205, USA. mcmillandonalde@exchange.uams.edu
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D000818:Animals; D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D002707:Chlordiazepoxide; D004193:Discrimination Learning; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D007273:Injections, Intramuscular; D008297:Male; D008694:Methamphetamine; D009042:Motivation; D010424:Pentobarbital; D010622:Phencyclidine; D012055:Reinforcement Schedule
D002492:Central Nervous System Depressants; D000697:Central Nervous System Stimulants; D000431:Ethanol; D008694:Methamphetamine; D002707:Chlordiazepoxide; D010424:Pentobarbital; D010622:Phencyclidine