title: Acute pancreatitis after cardiac transplantation and other cardiac procedures: case-control analysis in 24,631 patients.
abstract: Previous series have identified an increased risk of developing acute postoperative pancreatitis in heart transplant recipients and other cardiac surgical patients, and some suggest that mortality is significantly increased when pancreatitis occurs in the transplant setting. We conducted a retrospective case-control analysis of adult patients undergoing orthotopic heart transplant or other cardiac procedures from April 1985 through June 1996 at our medical center. Specific risk factors for outcome were assessed including low cardiac output, intra-aortic balloon pump usage, exogenous calcium repletion, immunosuppression, cytomegalovirus infection, cholelithiasis, prior pancreatitis, and Acute Physiology and Chronic Health Evaluation (APACHE) II scores. There was a 30-fold increase in the incidence of pancreatitis in the heart transplant group [12 of 394 (3%) vs 27 of 24,237 (0.1%); P < 0.01]. Compared with the nontransplant cardiopulmonary bypass patients, the transplant patients experienced a statistically significant increased incidence of immunosuppression and three or more risk factors. Transplant patients with pancreatitis demonstrated a significant increase in APACHE II scores and the incidence of three or more risk factors compared with their transplant control group. Patients undergoing nontransplant cardiac procedures and developing pancreatitis had significantly increased cross-clamp times, incidence of low cardiac output, APACHE II scores, and incidence of three or more risk factors compared with their nontransplant cohort. In conclusion, there is a significant increase in the incidence of pancreatitis after orthotopic heart transplant compared with other cardiac procedures. Analysis demonstrates the additive effect of multiple individual risk factors. Immunosuppression confers significant additional risk for pancreatitis in the orthotopic heart transplant patient.
authors.affiliation: Department of Surgery, Vanderbilt University Medical Center and St. Thomas Hospital, Nashville, Tennessee 37232-4753, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Herline
authors.forename: C W
authors.initials: CW
authors.lastname: Pinson
authors.forename: J K
authors.initials: JK
authors.lastname: Wright
authors.forename: J
authors.initials: J
authors.lastname: Debelak
authors.forename: Y
authors.initials: Y
authors.lastname: Shyr
authors.forename: D
authors.initials: D
authors.lastname: Harley
authors.forename: W
authors.initials: W
authors.lastname: Merrill
authors.forename: T
authors.initials: T
authors.lastname: Starkey
authors.forename: R
authors.initials: R
authors.lastname: Pierson
authors.forename: W C
authors.initials: WC
authors.lastname: Chapman
mesh_terms: D018806:APACHE; D000208:Acute Disease; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000706:statistics & numerical data; D016022:Case-Control Studies; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects* / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome