title: Infrequent genetic alterations of p53, p16 genes and polymorphism in fhit gene in Indian myelodysplastic syndrome.
abstract: Alterations in the tumor suppressor genes p53, p16, and fhit were studied in myelodysplastic syndrome (MDS) samples of Indian patients. PCR-SSCP analysis showed evidence for the presence of polymorphism in fhit gene in 7 of 15 samples. We failed to get any evidence for mutation in the p53, p16, and fhit genes. These results indicate that mutational inactivation of these genes may not play a major role in the development of myelodysplastic syndrome.
authors.affiliation: Cancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India. lckannan@dapsas1.weizmann.ac.il
authors.forename: K
authors.initials: K
authors.lastname: Kannan
authors.forename: R
authors.initials: R
authors.lastname: Tharu
authors.forename: P M
authors.initials: PM
authors.lastname: Gopinath
authors.forename: T P
authors.initials: TP
authors.lastname: Bharadwaj
authors.forename: A K
authors.initials: AK
authors.lastname: Munirajan
authors.forename: N
authors.initials: N
authors.lastname: Tsuchida
authors.forename: G
authors.initials: G
authors.lastname: Shanmugam
mesh_terms: D017766:Acid Anhydride Hydrolases; D019942:Genes, p16 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009363:Neoplasm Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D011506:Proteins; D000099170:Bis(5'-adenosyl)triphosphatase