title: Elimination of residual lipid contamination in single volume proton MR spectra of human brain.
abstract: Short echo time 1H NMR spectra of the human brain reveal signals from various metabolites. In addition, resonances from macromolecules are present that may provide further useful information in several brain diseases. The detection of all these signals is possible if excellent volume selection is obtained; even small lipid contamination from surrounding fat tissue leads to strong spectral contamination. It affects the macromolecule resonances in the 0.5 to 2.0 ppm region and some adjacent metabolite signals and jeopardizes their quantitative analysis. This paper demonstrates how spatial contamination from insufficiently dephased signals can be recognized, analysed, and removed in localized STEAM spectroscopy of the brain.
authors.affiliation: Sektion Exp. MR des ZNS, Abteilung für Neuroradiologie and Physikalisches Institut, Universität Tubingen, Germany. uwe.seeger@med.uni-tuebingen.de
authors.forename: U
authors.initials: U
authors.lastname: Seeger
authors.forename: U
authors.initials: U
authors.lastname: Klose
authors.forename: O
authors.initials: O
authors.lastname: Lutz
authors.forename: W
authors.initials: W
authors.lastname: Grodd
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D016477:Artifacts; D001853:Bone Marrow / Q000737:chemistry; D001923:Brain Chemistry; D006801:Humans; D008055:Lipids / Q000032:analysis*; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D009778:Occipital Lobe / Q000737:chemistry; D015203:Reproducibility of Results; D012886:Skull / Q000737:chemistry
chemical_list: D008055:Lipids; D046911:Macromolecular Substances