Fusaric acid and modification of the subchronic toxicity to rats of fumonisins in F. moniliforme culture material.
Fumonisins and fusaric acid (FA) are mycotoxins produced by Fusarium moniliforme and other Fusarium which grow on corn. Fumonisins cause animal toxicities associated with F. moniliforme and, like F. monliforme, they are suspected human oesophageal carcinogens. Toxic synergism was obtained by simultaneous administration of FA and fumonisin B1 to chicks in ovo. To determine the effect of FA on in vivo toxicity of F. moniliforme culture material (CM), male rats (12 groups, n = 5/ group) were fed diets containing 0.025, 0.10 or 2.5% CM (providing dietary levels of 3.4, 18.4 or 437 ppm fumonisins, respectively) to which, at each CM level, 0, 20, 100 or 400 ppm FA were added. Additionally, an FA control group was fed 400 ppm FA only and an untreated control group was given neither FA nor culture material. Apoptosis and other effects consistent with those caused by fumonisins were present in the kidneys of animals fed 0.025% or more CM and in the livers of animals fed 2.5% CM. FA was without effect. No differences between the untreated and FA control groups were noted and no differences among the four groups (0-400 ppm FA) fed 0.025% CM, the four groups fed 0.10% CM or the four groups fed 2.5% CM were apparent. Thus, FA exerted no synergistic, additive or antagonistic effects on the subchronic in vivo toxicity of fumonisin-producing F. moniliforme.
Voss
K A
KA
Toxicology and Mycotoxin Research Unit, United States Department of Agriculture, Agricultural Research Service, Richard B. Russell Agricultural Research Center, Athens, GA 30604-5677, USA.
Porter
J K
JK
Bacon
C W
CW
Meredith
F I
FI
Norred
W P
WP
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000187:drug effects; D002264:Carboxylic Acids / Q000633:toxicity*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating; D004798:Enzymes / Q000097:blood; D037341:Fumonisins; D005669:Fusaric Acid / Q000633:toxicity*; D005670:Fusarium; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D009183:Mycotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013107:Sphingolipids / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D002264:Carboxylic Acids; D004798:Enzymes; D037341:Fumonisins; D009183:Mycotoxins; D013107:Sphingolipids; D014280:Triglycerides; C056933:fumonisin B1; D002784:Cholesterol; D005669:Fusaric Acid