Frequency of sister chromatid exchange in chrysotile-exposed workers.
Chrysotile, which is an industrial carcinogen, has been shown to induce a dose-dependent increase in the frequency of sister chromatid exchange (SCE) in vitro. Authors designed this study to examine the increase of SCEs frequency in the workers occupationally exposed to chrysotile. Heparinized whole blood samples from 45 chrysotile-exposed and 45 control volunteers were cultured for 72 h. The significant difference of SCE frequency was found between chrysotile-exposed workers and control group. The highest SCEs frequency was found in chrysotile-exposed smokers, and the lowest in control non-smokers. The effect of chrysotile exposure on SCEs was marginally significant after controlling the effects of age and smoking by multiple regression analysis.
Lee
S H
SH
Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Banpodong, Seoul, South Korea. ashlee@cmc.cuk.ac.kr
Shin
M
M
Lee
K J
KJ
Lee
S Y
SY
Lee
J T
JT
Lee
Y H
YH
D000328:Adult; D000367:Age Factors; D000395:Air Pollutants, Occupational / Q000009:adverse effects* / Q000592:standards; D001194:Asbestos / Q000009:adverse effects* / Q000592:standards; D002273:Carcinogens / Q000009:adverse effects* / Q000592:standards; D005260:Female; D006801:Humans; D007723:Korea; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D012044:Regression Analysis; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects
D000395:Air Pollutants, Occupational; D002273:Carcinogens; D001194:Asbestos