Incorrectly folded aromatic polyketides from polyketide reductase deficient mutants.
Compounds produced by the polyketide ketoreductase deficient Streptomyces mutants HO61 and P67 are described. The structures of the compounds indicate that ketoreductase activity is required for correct condensation of the polyketide chain in the biosynthesis of aromatic polyketides.
Kunnari
T
T
Galilaeus Oy, Kaarina, Finland. tero.kunnari@galilaeus.fi
Ylihonko
K
K
Hautala
A
A
Klika
K D
KD
Mäntsälä
P
P
Hakala
J
J
D000429:Alcohol Oxidoreductases / Q000235:genetics*; D001426:Bacterial Proteins; D004988:Ethers, Cyclic / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D016296:Mutagenesis; D013302:Streptomyces / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D001426:Bacterial Proteins; D004988:Ethers, Cyclic; D000429:Alcohol Oxidoreductases; C087192:polyketide synthase ketoreductase