Nuclear transport: what a kary-on!
Compartmentalisation in eukaryotic cells presents special problems in macromolecular transport. Here we use the recently determined X-ray structures of a number of components of the nuclear transport machinery as a framework to review current understanding of this fundamental biological process.
Gamblin
S J
SJ
The Division of Protein Structure National Institute for Medical Research The Ridgeway, Mill Hill, London, NW7 1AA, UK. s-gambli@darwin.nimr.mrc.ac.uk.
Smerdon
S J
SJ
D000818:Animals; D001692:Biological Transport; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D028884:Karyopherins; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D020931:ran GTP-Binding Protein / Q000737:chemistry* / Q000378:metabolism*
D028884:Karyopherins; D009687:Nuclear Proteins; D020931:ran GTP-Binding Protein