[Guidance of commissural axons in the neural tube--related to the induction and differentiation of ventral neurons].
The floor plate cells, located at the ventral midline of the neural tube, secrete diffusible factors such as sonic hedgehog (shh) and netrin-1. It is known that shh induces motor neurons at the basal plate, and that netrin-1 contributes to axon pathfinding of spinal commissural neurons located at the dorsal spinal cord. This review focuses on and discusses the roles of signaling molecules expressed at the floor plate, the rostral diencephalic ventral midline cells, and their underlying tissues; the notochord and the prechordal mesoderm in the induction and differentiation of ventral neurons, and in the guidance of commissural axons.
Ohyama
K
K
Department of Anatomy, Keio University, School of Medicine, Tokyo, Japan.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002454:Cell Differentiation; D002490:Central Nervous System / Q000196:embryology*; D004627:Embryonic Induction; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000235:genetics; D009414:Nerve Growth Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics; D000075388:Netrin-1; D009474:Neurons / Q000166:cytology*; D011506:Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators; D016212:Transforming Growth Factor beta / Q000502:physiology; D025521:Tumor Suppressor Proteins
D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011506:Proteins; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1