title: Effects of ovariectomy on bone morphology in maxillae of mature rats.
abstract: Postmenopausal oestrogen deficiency results in bone loss (osteoporosis) in humans and experimental animals. The loss of trabecular bone in the ovariectomized (OVX) rat provides a useful experimental model of post-menopausal osteoporosis. At 5 months after ovariectomy of 3-month-old female rats, the mid and distal femurs and maxillae were dissected and processed for quantitative backscattered electron microscopic examinations. Histomorphometric analysis of femurs in OVX rats showed significant loss in metaphyseal trabecular bone areas compared with sham-operated controls; no significant bone loss was observed in the cortical bone areas of mid-diaphyses in OVX rats. Net bone areas in the maxillae of OVX rats was similar to that of sham-operated controls. Bone structure of maxillae in OVX rats was also similar to that in controls. Our results suggest that, in this animal model of osteoporosis, prominent bone loss occurs mainly in the bone areas formed by endochondral ossification such as distal femurs, but those areas formed by intramembranous ossification such as mid-femurs and maxillae sustained less effects by OVX.
authors.forename: A
authors.initials: A
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Debari
authors.forename: R
authors.initials: R
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Kawawa
authors.forename: N S
authors.initials: NS
authors.lastname: Ramamurthy
authors.forename: L M
authors.initials: LM
authors.lastname: Golub
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000648:ultrastructure*; D004195:Disease Models, Animal; D004967:Estrogens / Q000172:deficiency; D005260:Female; D005269:Femur / Q000648:ultrastructure; D006801:Humans; D008437:Maxilla / Q000648:ultrastructure; D008854:Microscopy, Electron / Q000379:methods; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000473:pathology; D010052:Ovariectomy / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012542:Scattering, Radiation
chemical_list: D004967:Estrogens