The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia.
Castilla
L H
LH
Garrett
L
L
Adya
N
N
Orlic
D
D
Dutra
A
A
Anderson
S
S
Owens
J
J
Eckhaus
M
M
Bodine
D
D
Liu
P P
PP
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D005038:Ethylnitrosourea / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006098:Granulocytes / Q000166:cytology*; D006410:Hematopoiesis / Q000235:genetics; D015479:Leukemia, Myelomonocytic, Acute / Q000139:chemically induced / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000009:adverse effects; D015514:Oncogene Proteins, Fusion / Q000235:genetics*
C095514:CBFbeta-MYH11 fusion protein; D009153:Mutagens; D015514:Oncogene Proteins, Fusion; D005038:Ethylnitrosourea