Determination of telomerase activity for differential analysis of multifocal renal cell carcinomas.
Secondary tumors are found in approximately 12 to 22% of all renal cell carcinoma, and their origin is currently unknown. To determine their potential for malignancy, we examined the telomerase activity of primary tumors and secondary lesions, and found that 86% of the lesions had an identical telomerase status as the related primary tumors, and thus probably share their malignancy potential.
Fiedler
W
W
Institute of Human Genetics and Anthropology, Department of Urology, Friedrich-Schiller-University Jena, Germany. WFIE@mti-n.uni-jena.de
Junker
K
K
Schlichter
A
A
Schubert
J
J
Ernst
G
G
Dahse
R
R
Claussen
U
U
D018262:Adenocarcinoma, Clear Cell / Q000201:enzymology / Q000556:secondary; D002292:Carcinoma, Renal Cell / Q000201:enzymology* / Q000556:secondary; D017931:DNA Primers; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology* / Q000556:secondary; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D017931:DNA Primers; D019098:Telomerase