title: Characterization and inhibitory effect of antibacterial dental resin composites incorporating silver-supported materials.
abstract: Resin composites with antibacterial activity may be useful for preventing the secondary caries frequently seen around restorations. The purposes of this study were to investigate antibacterial light-activated dental resin composites incorporating each of two silver-supported antibacterial materials and evaluate their long-lasting inhibitory effect against Streptococcus mutans. Two types of silver-supported antibacterial materials, Novaron (N) and Amenitop (AM) were used. These antibacterial materials were incorporated into TEGDMA-UDMA-based light-activated resin composites, and the antibacterial activities and mechanical properties of these composites, and also the release of silver ions, were examined. Two silver-supported antibacterial materials inhibited the growth of the major oral pathogen S. mutans. The minimum inhibitory concentration in suspensions of N and AM against S. mutans was 40 microg/mL and 30 microg/mL, respectively. Composites incorporating 5 wt % (N-5) or more of Novaron and 7 wt % (AM-7) or more of Amenitop inhibited the growth of S. mutans after immersion in water for 6 months. There was no or extremely little release of silver ions from the N-5 and AM-7 composites after 1 day or after 6 months of immersion in water. No significant difference in either compressive or flexural strength was observed between the control and the N-5 composites after 1 day or after 6 months of storage in water. However, for the AM-5 composite, there was a significant difference in both strength parameters between the two immersion periods. These results indicate that a light-activated dental resin composite incorporating silver-supported antibacterial material such as Novaron may be useful clinically because of its long-lasting inhibitory effect against S. mutans and its favorable mechanical properties.
authors.affiliation: Department of Fixed Prosthodontics, Nagasaki University School of Dentistry, 1-7-1, Sakamoto, Nagasaki 852-8588, Japan. keiichi@net.nagasaki-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Tanagawa
authors.forename: M
authors.initials: M
authors.lastname: Atsuta
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D003188:Composite Resins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012834:Silver; D013295:Streptococcus mutans / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003188:Composite Resins; D012834:Silver