[The evaluation of the effect of sodium fluoride concentration on the mechanical strength of the femoral bone in growing rats].
The aim of the study was to investigate the effects of different natrium fluoride concentrations on mechanical strength of femoral bone in young growing rats. Forty 6-weeks-old female Wistar rats were randomised into four groups. One group served as a control group receiving distilled water and the other three groups received fluoridated water with NaF at different doses (8, 30 and 60 mg F-/1). All rats were sacrificed after six weeks. The femoral bones were obtained from each rat, and bending strength of the femoral shaft and failure load of the femoral neck were assessed. Bending strength of the femoral shaft decreased significantly after fluoride therapy. The group receiving 8 mg F-/1 showed the highest failure load of the femoral neck, in comparison to the control group and groups receiving 30 and 60 mg F-/1.
Bohatyrewicz
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Katedra i Klinika Ortopedii i Traumatologii, Pomorska Akademia Medyczna w Szczecinie.
D000818:Animals; D005260:Female; D005269:Femur / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar / Q000502:physiology; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000032:analysis*; D013314:Stress, Mechanical
D012969:Sodium Fluoride