Sigmoid colon cancer associated with primary hyperparathyroidism: report of a case.
We present herein a case of sigmoid colon cancer associated with primary hyperparathyroidism (PHP). PHP is known to be associated with malignancy, and decreased intracolonic calcium (Ca) resulting from increased vitamin D (VD) levels may play a role in colorectal carcinogenesis. PHP was diagnosed in this patient by preoperative screening blood chemistry examination. The blood level of intact parathyroid hormone (PTH) was elevated and a parathyroid gland scintigram demonstrated abnormal uptake near the right lower lobe of the thyroid. There was no evidence of bone metastasis, and a sigmoid colectomy was performed with curative intent. The patient had an uneventful postoperative course without a critical elevation of the serum Ca level. This case report suggests that a relationship exists between PHP and colon cancer, and the possible mechanisms of this association are presented in our discussion.
Kawamura
Y J
YJ
Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Japan.
Kazama
S
S
Miyahara
T
T
Masaki
T
T
Muto
T
T
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D000368:Aged; D012809:Colon, Sigmoid / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications*