3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis.
Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities.
Pae
A N
AN
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
Kim
S Y
SY
Kim
H Y
HY
Joo
H J
HJ
Cho
Y S
YS
Choi
K I
KI
Choi
J H
JH
Koh
H Y
HY
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D010080:Oxazoles