title: Preparation and properties of totally synthetic immunogens.
abstract: Although the induction of antibodies and T cells by synthetic peptides representing defined antigenic determinants is a routine laboratory procedure, their use as vaccines has not yet been generally realised. There are a number of reasons for this and paramount is the limitation of valency which affects not only immunogenicity, but also the coverage of the antigenic universe. This paper is a review of our own work in which we have assembled synthetic peptides into multivalent artificial proteins and then examined their immunological properties.
authors.affiliation: Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, The University of Melbourne, Parkville, Australia. d.jackson@microbiology.unimelb.edu.au
authors.forename: D C
authors.initials: DC
authors.lastname: Jackson
authors.forename: C J
authors.initials: CJ
authors.lastname: Fitzmaurice
authors.forename: L E
authors.initials: LE
authors.lastname: Brown
authors.forename: W
authors.initials: W
authors.lastname: Zeng
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology; D014614:Vaccines, Synthetic
chemical_list: D000939:Epitopes; D014614:Vaccines, Synthetic