Role of gamma interferon in controlling murine chlamydial genital tract infection.
Earlier investigations have not shown an important role for gamma interferon (IFN-gamma) in the early clearance of chlamydial infection from the murine female genital tract. In a model using a human genital isolate of Chlamydia trachomatis in IFN-gamma and IFN-gamma receptor knockout mice, we were able to demonstrate a major role for IFN-gamma in mediating control of infection throughout the course of infection.
Ito
J I
JI
Department of Infectious Diseases, City of Hope National Medical Center, Duarte, California 91010, USA. jito@coh.org
Lyons
J M
JM
D000818:Animals; D002690:Chlamydia Infections / Q000276:immunology*; D002692:Chlamydia trachomatis; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D017471:Receptors, Interferon / Q000502:physiology; D000096743:Interferon gamma Receptor
D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor