title: Somatosensory evoked potentials in severe traumatic brain injury: a blinded study.
abstract: OBJECTIVE
  Beginning in 1979, the results of somatosensory evoked potential (SSEP) monitoring have been used to predict outcome in patients who have suffered severe brain trauma. The data indicate that if the cortical components of the SSEPs were bilaterally absent, the outcome was always death or a vegetative state, but previous studies have not been blinded. The aims of this study were to correlate the results of SSEP recordings with the outcome in a prospectively blinded manner and to assess whether monitoring of SSEPs was a useful adjunct to clinical judgment in the prediction of outcome.
  
  
  METHODS
  The authors studied 105 severely head injured patients (median Glasgow Coma Scale score of 6) who were admitted to the Waikato Intensive Care Unit. The upper limb SSEPs were classified according to the central conduction time (CCT) as normal, of increased latency, or absent. The outcome as assessed using the Glasgow Outcome Scale (GOS) score was evaluated 12 months after the injury.
  
  
  CONCLUSIONS
  Of 51 patients with a bilaterally normal CCT, 29 (57%) had a good outcome (GOS Score 5). Any delay in CCT was associated with a decreased incidence of good outcome (30%). Unilateral absence of the cortical component of the SSEP was usually associated with a poor outcome (death or severe disability), and bilateral absence was always associated with a poor outcome. The authors conclude that SSEPs correlate well with outcome and that this is not the result of investigator bias.
authors.affiliation: Department of Intensive Care, Waikato Hospital, Hamilton, New Zealand. sleighj@hwl.co.nz
authors.forename: J W
authors.initials: JW
authors.lastname: Sleigh
authors.forename: J H
authors.initials: JH
authors.lastname: Havill
authors.forename: R
authors.initials: R
authors.lastname: Frith
authors.forename: D
authors.initials: D
authors.lastname: Kersel
authors.forename: N
authors.initials: N
authors.lastname: Marsh
authors.forename: D
authors.initials: D
authors.lastname: Ulyatt
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000401:mortality / Q000503:physiopathology*; D006233:Persons with Disabilities; D005073:Evoked Potentials, Somatosensory; D015600:Glasgow Coma Scale; D006801:Humans; D009431:Neural Conduction; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011930:Reaction Time; D016037:Single-Blind Method; D013997:Time Factors