Site-specific consultation for a chemical mixture.
The Agency for Toxic Substances and Disease Registry (ATSDR) uses the weight of evidence methodology to evaluate interactions of chemical mixtures. In the process, toxicity, toxicokinetics, and toxicodynamics of chemical components of the mixture are carefully examined. Based on the evaluation, predictions are made that can be used in real-life situations at hazardous waste sites. In this paper, health outcomes were evaluated for a mixture of eight compounds that were found at a specific site. These eight chemicals were identified and possibly associated with human exposure. The health assessors could consider similar thought processes when evaluating chemical mixtures at hazardous waste sites.
Pohl
H R
HR
Agency for Toxic Substances and Disease Registry, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
Roney
N
N
Fay
M
M
Chou
C H
CH
Wilbur
S
S
Holler
J
J
D000814:Aniline Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D000880:Anthraquinones / Q000493:pharmacokinetics / Q000633:toxicity; D001391:Azo Compounds / Q000493:pharmacokinetics / Q000633:toxicity; D004146:Dioxanes / Q000493:pharmacokinetics / Q000633:toxicity; D004347:Drug Interactions; D004781:Environmental Exposure / Q000009:adverse effects*; D004811:Epichlorohydrin / Q000493:pharmacokinetics / Q000633:toxicity; D015386:Hazardous Substances / Q000493:pharmacokinetics / Q000633:toxicity*; D006256:Hazardous Waste / Q000009:adverse effects*; D006801:Humans; D019800:Phenol / Q000493:pharmacokinetics / Q000633:toxicity; D011108:Polymers / Q000493:pharmacokinetics / Q000633:toxicity; D011409:Propylene Glycols / Q000493:pharmacokinetics / Q000633:toxicity; D018570:Risk Assessment; D014481:United States; D014483:United States Dept. of Health and Human Services
D000814:Aniline Compounds; D000880:Anthraquinones; D001391:Azo Compounds; D004146:Dioxanes; D015386:Hazardous Substances; D006256:Hazardous Waste; D011108:Polymers; D011409:Propylene Glycols; D004811:Epichlorohydrin; C012504:polypropylene glycol; D019800:Phenol; C025223:1,4-dioxane; C003898:2-anisidine; C023650:aniline