[The pharmacological correction of hemodynamics during the simulation of the early period of adaptation to weightlessness].
Investigations of volunteered subjects in whom antiorthostatic hypokinesia was modeled by tilting the cranial end of the body by -15 degrees were to answer whether pharmacological countermeasures of the vestibular/autonomous syndrome (motion sickness, sea sickness) alter the orthostatic tolerance and cardiovascular parameters. As was stated, the drugs allow controlled correction of hemodynamic resistance to the head-down tilt. Ephedrine, phencarol, ephedrine combined with scopolamine and pipolphen, and stugeron normalized cerebral circulation. Medicaments were unable to moderate the sympathoadrenal reaction to the head-down tilt; however, blood concentrations of catecholamines were significantly lower than in the control. The greatest effect was achieved using ephedrine and ephedrine plus pipolphen.
Shashko
V S
VS
Modin
A Iu
AIu
Il'ina
S L
SL
Sabaev
V V
VV
Shashkov
A V
AV
Potapov
M G
MG
D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D004452:Echocardiography / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D010992:Plethysmography, Impedance / Q000187:drug effects; D018667:Tilt-Table Test / Q000379:methods / Q000706:statistics & numerical data; D013997:Time Factors; D018474:Weightlessness Simulation / Q000379:methods / Q000706:statistics & numerical data; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes