Topical ephedrine administration and nasal chemosensory function in healthy human subjects.
OBJECTIVE
To investigate dose-related effects of ephedrine on olfactory function in healthy subjects.


METHODS
Placebo-controlled, randomized, double-blind study.


METHODS
Drug effects were assessed using olfactory and trigeminal psychophysical measures (intensity ratings, odor discrimination, butanol and formic acid thresholds); nasal patency was assessed by means of anterior rhinoresistometry. The investigation was performed in 24 healthy volunteers; subjects were assigned to treatments A, B, or C (3 groups with 8 subjects each; 4 women and 4 men per group). All subjects received either placebo or ephedrine in both nostrils; group A subjects received placebo, and group B and C subjects received ephedrine in dosages of 0.12 and 0.24 mg, respectively.


RESULTS
Treatment with ephedrine produced a tendency toward an increase of nasal airflow. However, during the time of observation there was no significant difference between effects produced by the 2 dosages. Ephedrine had no systematic effect on measures of olfactory function. The only significant correlation to the nasal airflow was found for perceived intensity of the trigeminal stimuli, which increased with increasing flow.


CONCLUSIONS
Ephedrine appeared to have neither negative nor major positive effects on intranasal chemosensory function in healthy subjects. This indicates that ephedrine may be used as a decongestant in studies on olfaction.
Temmel
A F
AF
Department of Otorhinolaryngology, University of Vienna, Austria. andreas.temmel@akh-wien.ac.at
Quint
C
C
Toth
J
J
Herneth
A
A
Hummel
T
T
D000281:Administration, Intranasal; D000328:Adult; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004311:Double-Blind Method; D004809:Ephedrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects*; D011601:Psychophysics; D012123:Pulmonary Ventilation / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D012903:Smell / Q000187:drug effects*; D014276:Trigeminal Nerve / Q000187:drug effects
D004809:Ephedrine