Comparison of the response to histamine challenge of the nose and the maxillary sinus: effect of loratadine.
To study the response of the maxillary sinus to histamine provocation, we performed a double-blind, randomized, crossover trial during which nonallergic subjects without symptoms of rhinitis (n = 25) received either 10 mg loratadine or placebo once daily for a week and then underwent nasal challenge with histamine (3, 10, and 30 mg/ml) followed, 24 h later, by a maxillary sinus challenge while still receiving the medication. Nasal challenge with histamine led to significant increases in vascular permeability, reflex nasal secretions, sneezing, and other nasal symptoms. Sinus challenge resulted in significant increases in vascular permeability within the sinus cavity (P < 0.01) and some nasal symptoms but no significant change in reflex nasal secretions. The response of the sinus mucosa to histamine was lower in magnitude than that of the nose. Treatment with loratadine resulted in a significant inhibition of the histamine-induced changes in both nasal and sinus cavities. Our data suggest the lack of a sinonasal reflex response to histamine provocation of the maxillary sinus of nonallergic individuals.
Baroody
F M
FM
Section of Otolaryngology-Head and Neck Surgery, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA. fbaroody@surgery.bsd.uchicago.edu
Gungor
A
A
deTineo
M
M
Haney
L
L
Blair
C
C
Naclerio
R M
RM
D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000503:physiopathology; D017336:Loratadine / Q000494:pharmacology*; D008297:Male; D008443:Maxillary Sinus / Q000187:drug effects / Q000502:physiology*; D009666:Nose / Q000187:drug effects / Q000502:physiology*; D010865:Pilot Projects; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D012709:Serum Albumin / Q000378:metabolism; D012912:Sneezing / Q000502:physiology
D006634:Histamine H1 Antagonists; D012709:Serum Albumin; D017336:Loratadine; D006632:Histamine