title: Axolotl MHC architecture and polymorphism.
abstract: The MHC of the urodele amphibian Ambystoma mexicanum consists of multiple polymorphic class I loci linked, so far as yet known, to a single class II B locus. This architecture is very different from that of the anuran amphibian Xenopus. The number of class I loci in the axolotl can vary from 6 to 21 according to the haplotypes as shown by cDNA analysis and Southern blot studies in families. These loci can be classified into seven sequence groups with features ranging from the class Ia to the class Ib type. All individuals express genes from at least three of the seven groups, and all individuals possess the class Ia-like type.
authors.affiliation: Basel Institute for Immunology Basel, Switzerland. sammut@bii.ch
authors.forename: B
authors.initials: B
authors.lastname: Sammut
authors.forename: L
authors.initials: L
authors.lastname: Du Pasquier
authors.forename: P
authors.initials: P
authors.lastname: Ducoroy
authors.forename: V
authors.initials: V
authors.lastname: Laurens
authors.forename: A
authors.initials: A
authors.lastname: Marcuz
authors.forename: A
authors.initials: A
authors.lastname: Tournefier
mesh_terms: D000557:Ambystoma / Q000235:genetics* / Q000276:immunology*; D000595:Amino Acid Sequence; D000818:Animals; D015139:Blotting, Southern; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005805:Genes, MHC Class I / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D015789:HLA-A2 Antigen / Q000737:chemistry; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics* / Q000276:immunology*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000276:immunology*; D011487:Protein Conformation
chemical_list: D015789:HLA-A2 Antigen