title: Effects of recombinant nitrophorin-2 nitric oxide complex on vascular smooth muscle.
abstract: Nitrophorin-2, isolated from the salivary gland of the blood-sucking insect Rhodnius prolixus, is a nitric oxide (NO) binding protein. We investigated the effects of recombinant nitrophorin-2 NO complex on vascular smooth muscle. The course of relaxation was relative to released NO from recombinant nitrophorin-2 NO complex. Our data suggested nitrophorin-2 was tightly adhesive to the membranes to transport NO into the cell during the insect sting.
authors.affiliation: Department of Medical Zoology, School of Medicine, Mie University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kaneko
authors.forename: H
authors.initials: H
authors.lastname: Shojo
authors.forename: M
authors.initials: M
authors.lastname: Yuda
authors.forename: Y
authors.initials: Y
authors.lastname: Chinzei
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism; D006420:Hemeproteins / Q000737:chemistry / Q000494:pharmacology*; D019476:Insect Proteins / Q000737:chemistry / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D011994:Recombinant Proteins / Q000737:chemistry / Q000494:pharmacology; D012471:Salivary Proteins and Peptides / Q000737:chemistry / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006420:Hemeproteins; D019476:Insect Proteins; D011994:Recombinant Proteins; D012471:Salivary Proteins and Peptides; D014665:Vasodilator Agents; C090560:nitrophorin; D009569:Nitric Oxide; D006152:Cyclic GMP