[The linkage of the major histocompatibility complex to autoimmune thyroid diseases].
To investigate the association between human leukocyte antigen (HLA) and development of autoimmune thyroid diseases such as Graves' disease (GD), Hashimoto's thyroiditis (HT), and Graves' disease patients with undetectable TSH-binding inhibitor immunoglobulin (TBII-negative GD), HLA typing was done. 1. We previously reported increased frequencies of HLA-A2 and DPB1*0501 in TBII-positive GD patients, 2. significantly increased frequencies of HLA-A2 and DPB4*0101 in patients with HT, 3. more TBII-negative GD patients having both HLA-B46 and DPB1*0202 than those having each allele alone, suggesting that these 2 alleles may play a synergistic role in controlling the susceptibility to TBII-negative GD, and 4. contrarily that the frequencies of DQA1*0102 in HT patients and of DQB1*0501 in GD patients were significantly decreased, suggesting that DQA1*0102 and DQB1*0501 might confer resistance to the development of HT and GD.
Tamai
H
H
Kuma Hospital.
Matsubayashi
S
S
Kimura
A
A
D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics* / Q000276:immunology; D008297:Male; D013959:Thyroid Diseases / Q000235:genetics* / Q000276:immunology