title: Lineages and transcription factors in the specification of vertebrate primary sensory neurons.
abstract: Recent advances have indentified some of the key transcriptional regulators of mammalian genes, the neurogenins. Neurogenins 1 and 2 appear to control distinct sublineages for different classes of sensory neurons, including a 'pioneer' lineage for proprioceptors specified early in neural crest migration. Neurogenins act via a cascade of downstream transcriptional regulators, some of which have been identified.
authors.affiliation: Howard Hughes Medical Institute Division of Biology 216-76 California Institute of Technology Pasadena, California 91125, USA. barres@stanford.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Anderson
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002460:Cell Line / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology*; D029867:Xenopus Proteins
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C101907:neurogenin, Xenopus