title: Autoreactive T cells in murine lupus: origins and roles in autoantibody production.
abstract: The conventional paradigm to explain systemic lupus erythematosus (SLE) is that disease results from tissue deposition of pathogenic autoantibodies and immune complexes, secondary to activation of autoreactive B cells in the context of help from alphabeta T cells. Recent work in murine lupus has confirmed this notion and demonstrated that autoantigen-specific alphabeta T cells are absolutely required for full penetrance of disease, with such autoreactive alphabeta T cells, even in Fas-intact mice, likely arising from defects in peripheral tolerance. These studies have also revealed a network of regulation that also involves nonclassical pathogenic and downregulatory alphabeta and gammadelta T cells, suggesting that the lupus immune system involves more complex interactions than the conventional paradigm suggests.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8031, USA. joseph.craft@yale.edu
authors.forename: J
authors.initials: J
authors.lastname: Craft
authors.forename: S
authors.initials: S
authors.lastname: Peng
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: S
authors.initials: S
authors.lastname: Fatenejad
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D004195:Disease Models, Animal; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001323:Autoantibodies