title: [Activity leakage and radiation exposure in radiation synovectomy of the knee: influence of different therapeutic modalities].
abstract: In rheumatic diseases, radiation synovectomy is a reliable method. Meanwhile, radiation synovectomy is an outpatient therapy. In addition, combination with arthroscopic synovectomy is an increasing therapeutic modality. In comparison to the hitherto inpatient modality, a greater lymphatic emigration of the radionuclide and, therefore, a higher radiation exposure is possible. In 35 patients we found radionuclide emigration in 17 cases by whole body scintigraphy, resulting in a 50%-percentile with 68.27%-confidence interval of 1.8 (0.45-4.78)% of the injected yttrium-90-activity. Comparison of 3 groups with the above mentioned therapy modalities resulted in no statistical difference (p>0.05). Because of the found radionuclide emigration, a radiation dose of 0. 1 (0.05-0,18) mSv in women and 0.2 (0.1-0.38) mSv in men was calculated. For lymph nodes, liver, spleen and whole body radiation doses of 619 (154-1644) mSv, 62 (15-165) mSv, 62 (15-165) mSv and 37 (9-99) mSv were calculated. Gonadal radiation dose can be neglected and the morbidity rate for tumors because of the whole body radiation dose is low with a value of 0.4 per thousand. Therefore, radiation synovectomy can be used unlimited by patients age and independent of the therapeutic modality.
authors.affiliation: Klinik für Nuklearmedizin, Klinikum der JLU, Giessen, Friedrichstr. 25 D-35385, Giessen.
authors.forename: R
authors.initials: R
authors.lastname: Klett
authors.forename: M
authors.initials: M
authors.lastname: Puille
authors.forename: H P
authors.initials: HP
authors.lastname: Matter
authors.forename: D
authors.initials: D
authors.lastname: Steiner
authors.forename: H
authors.initials: H
authors.lastname: Stürz
authors.forename: R
authors.initials: R
authors.lastname: Bauer
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011836:Radiation Tolerance; D011874:Radiometry; D011879:Radiotherapy Dosage; D013583:Synovial Membrane / Q000528:radiation effects*; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D015021:Yttrium Radioisotopes