title: Adult asthmatics sensitized to cats and dogs: symptoms, severity, and bronchial hyperresponsiveness in patients with furred animals at home and patients without these animals.
abstract: BACKGROUND
  Domestic furred animals are important sources of allergens in asthma, but few clinical studies have investigated the effects of exposure to or elimination of these allergens. The objective of this study was to investigate whether pet-sensitized asthmatics with pets at home have worsened asthma, compared with similar asthmatics without pets.
  
  
  METHODS
  In a cross-sectional epidemiologic study, 129 adult asthmatics sensitized to cats or dogs were investigated by interviews, skin prick tests, specific IgE, eosinophil counts, and bronchial methacholine challenge tests. Patients with a cat or dog at home (n=39) were compared with subjects without pets (n=90).
  
  
  RESULTS
  More subjects with pets had symptoms, inhaled or oral steroids, abnormal peak-flow records, higher eosinophil counts, and a higher degree of bronchial hyperresponsiveness than subjects without pets. Asthmatics with pets more frequently ascribed their symptoms to their home environment, but fewer of them reported that their symptoms were elicited by contact with cats or dogs.
  
  
  CONCLUSIONS
  This study strongly indicates that living with a cat or a dog aggravates symptoms and biomarkers of airway inflammation in asthmatics sensitized to cats or dogs. The study indicates that avoidance of these allergens may be an important measure in the treatment of sensitized asthmatics.
authors.affiliation: Department of Medicine, Roskilde County Hospital, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Plaschke
authors.forename: C
authors.initials: C
authors.lastname: Janson
authors.forename: B
authors.initials: B
authors.lastname: Balder
authors.forename: O
authors.initials: O
authors.lastname: Löwhagen
authors.forename: B
authors.initials: B
authors.lastname: Järvholm
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D000818:Animals; D000829:Animals, Domestic; D001249:Asthma / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity; D001985:Bronchial Provocation Tests; D002415:Cats; D003430:Cross-Sectional Studies; D004285:Dogs; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate
chemical_list: D000485:Allergens; D007073:Immunoglobulin E