Itraconazole oral solution for the treatment of tinea capitis using the pulse regimen.
A 7-year-old boy with Trichophyton tonsurans tinea capitis was cured following the administration of itraconazole oral solution. He had difficulty swallowing tablets or capsules, so the availability of the oral solution was particularly advantageous. The itraconazole was given once daily in a fasting state at a dosage of 3 mg/kg/day as a pulse lasting 1 week. The first two pulses were separated by 2 weeks and the second and third pulse by 3 weeks. The decision whether or not to administer the third pulse was guided by the presence of clinical symptoms and signs of tinea capitis just prior to the scheduled administration. The availability of the oral solution will enable more young children to be considered for treatment of tinea capitis with itraconazole than was possible when only tablets or capsules were available.
Gupta
A K
AK
Department of Dermatology, Sunnybrook Health Science Center, Toronto, Ontario, Canada. agupta@execulink.com
Adam
P
P
Soloman
R
R
Aly
R
R
D000284:Administration, Oral; D000505:Alopecia / Q000209:etiology; D002648:Child; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D014006:Tinea Capitis / Q000150:complications / Q000188:drug therapy*
D017964:Itraconazole