[The role of the oxygen-binding properties of the blood in maintaining pro-oxidant-antioxidant equilibrium in the body].
Tissue pro-oxidant generation under standard conditions is equilibrated with the activity of intra- and extracellular antioxidants; thus some optimal level of pro-oxidant-antioxidant balance is created. Oxygen-dependent nature of lipid peroxidation processes implicates its complex multilevel regulatory system, where systemic mechanisms may dominate upon the intracellular ones. This suggests a necessity in the investigation of body oxygen transport not only in terms of the requirements of energetic metabolism in electron acceptor but also as a physiological mechanism for antioxidant defense and, in general, as the mechanism involved in a maintenance of pro-oxidant-antioxidant balance. The hemoglobin-oxygen affinity has a special place in a complex antioxidant system hierarchy, because it determines the condition of oxygen diffusion to tissues and ultimately the value of tissue pO2. The blood oxygen-binding properties under different hyperthermic states with or without a correction of hemoglobin-oxygen affinity and L-arginine-NO pathway were shown to be involved into a complex integration with elements of different functional systems and to play an important role in complex physiologic mechanisms for the maintenance of pro-oxidant-antioxidant balance. The oxyhemoglobin dissociation curve shift leftwards may have an adaptive effect under conditions of low oxygen utilization because of limitation of oxygen fraction spent on a free radical generation and the following initiation of lipid peroxidation processes.
Zinchuk
V V
VV
Grodno Medical Institute, Belarus.
Borisiuk
M V
MV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005609:Free Radicals / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D010100:Oxygen / Q000097:blood*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D005609:Free Radicals; D006454:Hemoglobins; D017382:Reactive Oxygen Species; D010100:Oxygen