General anaesthetic actions on ligand-gated ion channels.
The molecular mechanisms of general anaesthetics have remained largely obscure since their introduction into clinical practice just over 150 years ago. This review describes the actions of general anaesthetics on mammalian neurotransmitter-gated ion channels. As a result of research during the last several decades, ligand-gated ion channels have emerged as promising molecular targets for the central nervous system effects of general anaesthetics. The last 10 years have witnessed an explosion of studies of anaesthetic modulation of recombinant ligand-gated ion channels, including recent studies which utilize chimeric and mutated receptors to identify regions of ligand-gated ion channels important for the actions of general anaesthetics. Exciting future directions include structural biology and gene-targeting approaches to further the understanding of general anaesthetic molecular mechanisms.
Krasowski
M D
MD
Committee on Neurobiology, University of Chicago, Whitman Laboratory, Illinois 60637, USA. kra3@harper.uchicago.edu
Harrison
N L
NL
D018681:Anesthetics, General / Q000494:pharmacology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D008024:Ligands; D008322:Mammals; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology
D018681:Anesthetics, General; D007473:Ion Channels; D008024:Ligands; D011956:Receptors, Cell Surface