New animal lectin structures.
The past year has provided the X-ray crystal structures of both the N-terminal domain of sialoadhesin and the extracytoplasmic domain of the cation-dependent mannose 6-phosphate receptor. These structures represent the first examples from the I- and P-type lectin families and provide important insights into how these transmembrane-spanning receptors function. In addition, structures of galectin-7 and of the carbohydrate-recognition domain of galectin-3 have given evidence of a new galectin quaternary structure. Finally, the structure of tachylectin-2, the first example of a fivefold symmetric beta-propeller protein, sheds light on the role played by this lectin in horseshoe crab host defense.
Rini
J M
JM
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. james.rini@utoronto.ca
Lobsanov
Y D
YD
D000818:Animals; D000943:Antigens, Differentiation / Q000737:chemistry; D037502:Galectin 3; D037161:Galectins; D006801:Humans; D037102:Lectins / Q000737:chemistry*; D008562:Membrane Glycoproteins / Q000737:chemistry; D008958:Models, Molecular; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D017527:Receptor, IGF Type 2 / Q000737:chemistry; D011971:Receptors, Immunologic / Q000737:chemistry; D063267:Sialic Acid Binding Ig-like Lectin 1
D000943:Antigens, Differentiation; D037502:Galectin 3; D037161:Galectins; C097500:L10 protein, Tachypleus tridentatus; C092525:LGALS7 protein, human; D037102:Lectins; D008562:Membrane Glycoproteins; D017527:Receptor, IGF Type 2; D011971:Receptors, Immunologic; C571166:SIGLEC1 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1