Nefazadone-induced acute dystonic reaction.
A 53-y-o patient presented approximately 2 h after taking her first dose of nefazadone. Chief complaint was lip smacking with hand and arm gesturing. The patient also took 25 mg meclizine which she had used before with no adverse effects. Diphenhydramine followed by benztropine led to resolution of symptoms within 1 h. Patient subsequently used meclizine with no untoward reactions. Nefazadone should be added to the list of agents that cause acute dystonic reactions.
Burda
A
A
Illinois Poison Center, Chicago, USA.
Webster
K
K
Leikin
J B
JB
Chan
S B
SB
Stokes
K A
KA
D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning; D000932:Antiemetics / Q000627:therapeutic use; D001590:Benztropine / Q000627:therapeutic use*; D004155:Diphenhydramine / Q000627:therapeutic use*; D004347:Drug Interactions; D004421:Dystonia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008468:Meclizine / Q000494:pharmacology*; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D010879:Piperazines; D013997:Time Factors; D014230:Triazoles / Q000506:poisoning*
D018687:Antidepressive Agents, Second-Generation; D000932:Antiemetics; D010276:Parasympatholytics; D010879:Piperazines; D014230:Triazoles; D001590:Benztropine; D008468:Meclizine; C051752:nefazodone; D004155:Diphenhydramine