Building a cellular switch: more lessons from a good egg.
Xenopus oocytes mature in response to the steroid hormone progesterone. At the level of a population of oocytes, the response is graded-the higher the concentration of progesterone, the larger the fraction of oocytes that will mature-but at the level of the individual oocyte, the response is all-or-none. The all-or-none character of this cell fate switch is hypothesized to arise out of two properties of the signal transduction machinery that mediates maturation, positive feedback, and ultrasensitivity. This combination of positive feedback plus ultrasensitivity crops up again and again in cellular switches, from the lysis-lysogeny switch in phage-infected bacteria to the action potential in neurons.
Ferrell
J E
JE
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5332, USA. ferrell@cmgm.stanford.edu
D000818:Animals; D005246:Feedback; D005260:Female; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008954:Models, Biological; D009865:Oocytes / Q000254:growth & development / Q000378:metabolism*; D009866:Oogenesis; D015398:Signal Transduction; D014981:Xenopus / Q000254:growth & development / Q000378:metabolism*
D020928:Mitogen-Activated Protein Kinases