title: Helicobacter antibodies in Finnish centenarians.
abstract: BACKGROUND
  The prevalence of helicobacter antibodies increases with age and, in many developed countries, is highest in people born before 1940. Data on very old subjects are, however, limited. In this study we wanted to determine whether the age-related increase in the seroprevalence of H. pylori infection continues even in the oldest age group alive in Finland, the centenarians.
  
  
  METHODS
  Sera from 173 subjects (93% of all centenarians alive in Finland in 1991) were available for the present study. IgG and IgA antibodies against H. pylori were determined by an in-house enzyme immunoassay. To estimate the influence of atrophic gastritis on the prevalence of helicobacter antibodies, serum pepsinogen I (PG I) concentrations and parietal cell antibodies (PCAs) were measured by an enzyme immunoassay and indirect immunofluorescence, respectively.
  
  
  RESULTS
  The prevalence of helicobacter antibodies in Finnish centenarians was 66%. Low PG I values (<28 microg/l) were found in 36% and positive PCAs in 16% of the subjects studied. The prevalence of PCAs was especially high (50%) in H. pylori-negative subjects with low PG I values, suggesting severe gastric atrophy.
  
  
  CONCLUSIONS
  The age-related increase in H. pylori seroprevalence did not continue in the oldest age group alive in Finland. This may be explained partly by a relatively high frequency of atrophic gastritis (as suggested by low PG I values) in H. pylori-negative centenarians, but other factors--such as selective H. pylori-related mortality--may also have contributed to the fairly low seroprevalence (66%) observed.
authors.affiliation: Department of Bacteriology and Immunology, The Haartman Institute, University of Helsinki, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Rehnberg-Laiho
authors.forename: J
authors.initials: J
authors.lastname: Louhija
authors.forename: H
authors.initials: H
authors.lastname: Rautelin
authors.forename: J
authors.initials: J
authors.lastname: Jusufovic
authors.forename: R
authors.initials: R
authors.lastname: Tilvis
authors.forename: A
authors.initials: A
authors.lastname: Miettinen
authors.forename: T U
authors.initials: TU
authors.lastname: Kosunen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D005387:Finland / Q000453:epidemiology; D019084:Fluorescent Antibody Technique, Indirect; D005757:Gastritis, Atrophic / Q000453:epidemiology / Q000382:microbiology; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D020116:Pepsinogen A / Q000097:blood; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D020116:Pepsinogen A