title: Monte Carlo calculations of dose distributions around 32P and 198Au stents for intravascular brachytherapy.
abstract: 3D dose distributions are calculated for a 32P impregnated stent and a 198Au stent for intravascular brachytherapy with the EGS4 Monte Carlo simulation code. The stents were modeled as a combination of eight helicoidal struts. This allowed investigation of the effect of the stent geometry and the electron absorption in the strut material on the dose distributions. Absorbed dose to water was calculated at radial distances ranging from 50 microm to 5 mm from the stent surface. The dose distributions around the stents are compared to the dose distribution around an intravascular brachy-therapy 192Ir source, also calculated with the EGS4 Monte Carlo code. The dose profiles near the struts show hot spots. At 50 microm distance a peak to valley ratio of 3 for 32P and 6 for 198Au in the dose distribution is obtained. For both the isotopes the inhomogeneities decrease with distance and at a radial depth of 350 microm the effect becomes negligible. The calculations showed the importance of the effect of the absorption in the stent material as this leads to a dose decrease to 67% for the 198Au stent and to 77% for 32P near the stent at a distance of 2 mm from the stent axis. It is concluded that from the dosimetric point of view, the 198Au stent is inferior to the 32P stent and the 192Ir source. Application of the 198Au stent in clinical practice requires further investigation of the importance of the adventitia in the restenosis process, and the tolerance dose of the intima.
authors.affiliation: Department of Biomedical Physics, University of Gent, Belgium.
authors.forename: N
authors.initials: N
authors.lastname: Reynaert
authors.forename: F
authors.initials: F
authors.lastname: Verhaegen
authors.forename: Y
authors.initials: Y
authors.lastname: Taeymans
authors.forename: M
authors.initials: M
authors.lastname: Van Eijkeren
authors.forename: H
authors.initials: H
authors.lastname: Thierens
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D055592:Biophysical Phenomena; D001703:Biophysics; D001808:Blood Vessels / Q000528:radiation effects*; D001918:Brachytherapy / Q000295:instrumentation* / Q000706:statistics & numerical data; D003251:Constriction, Pathologic; D006050:Gold Radioisotopes / Q000627:therapeutic use; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009010:Monte Carlo Method; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use; D011880:Radiotherapy Planning, Computer-Assisted / Q000706:statistics & numerical data; D015607:Stents
chemical_list: D006050:Gold Radioisotopes; D010761:Phosphorus Radioisotopes