title: Demonstration of HPV 24 in long-standing Heck's disease with malignant transformation.
abstract: We report on the rare case of a 64-year-old European woman with a viral acanthoma of the oral mucosa of the clinical Heck type with unprecedented molecular-biological proof of HPV 24 DNA and so far undescribed malignant transformation with a long existence of the vegetation. After surgical therapy a circumscribed relapse of viral acanthoma developed, which responded favourably to a combined antiviral and antiproliferative therapy with acitretin perorally and interferon, first subcutaneously, later intralesionally for 3 months.
authors.affiliation: Department of Dermatology and Venerology, Otto-von-Guericke-University, Magdeburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Niebrügge
authors.forename: E
authors.initials: E
authors.lastname: Villiers
authors.forename: K
authors.initials: K
authors.lastname: Gerlach
authors.forename: I
authors.initials: I
authors.lastname: Franke
authors.forename: H
authors.initials: H
authors.lastname: Gollnick
mesh_terms: D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000473:pathology / Q000821:virology*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology*; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000473:pathology*
chemical_list: D004279:DNA, Viral