Cerebral blood flow regulation under activation of the primary somatosensory cortex during electrical stimulation of the forearm.
Coupling of neuronal activity to cerebral blood flow (CBF) is widely accepted, but the exact mechanism is still under investigation. We assessed the responses of CBF coupled with electrical activity over the primary somatosensory cortex (S-I) during electrical stimulation of the contralateral forearm in cats. CBF in S-I was monitored using laser-Doppler flowmetry (LDF), and electrical activity was recorded with a tungsten microelectrode. The effects of varying stimulus intensity and frequency were examined to assess the optimal stimulation parameters. CBF increased within 10 sec after onset of stimulation, sustained the plateau level, and returned to the pre-stimulus level after cessation of stimulation. The maximum response was obtained at 4 Hz under a constant intensity. Optimal stimulus intensity at 4 Hz ranged from 8 to 10 V. At intensity higher than 10 V, CBF increases reached a near-plateau level, while mean arterial blood pressure (MABP) decreased slightly. Electrical activity was recorded at the same restricted area where CBF increased. Low frequency components of the power spectrum of electrical activity increased as the CBF increase became greater. A tight coupling of CBF increases to neuronal activation is suggested, and CBF regulation may be affected by stimulation parameters.
Ichimi
K
K
Department of Neurosurgery, Nagoya University School of Medicine, Japan.
Kuchiwaki
H
H
Inao
S
S
Shibayama
M
M
Yoshida
J
J
D000818:Animals; D002415:Cats; D002536:Cerebral Arteries / Q000502:physiology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D005542:Forearm / Q000502:physiology; D017078:Laser-Doppler Flowmetry; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D009474:Neurons / Q000502:physiology; D013003:Somatosensory Cortex / Q000098:blood supply / Q000502:physiology*