[The laboratory diagnosis of autoimmune thyroid diseases in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station].
Serum antibodies to thyroid tissue antigens were tested by enzyme immunoassay and the thyroid hormonal status was analyzed in 80 liquidators of the Chernobyl accident consequences. Antibodies to thyroglobulin in concentration of 160.7 +/- 10.5 IU/ml were detected in 11 (13.7%) subjects 11-12 years after the accident. Antibodies to thyroperoxidase were detected in this cohort: the reaction was positive in 2.5% cases and weakly positive in 5%. Groups of liquidators with changed thyroid functional activity in the T3-T4-TTH system were identified. Immunochemical screening for thyroid hormones and antibodies is an affective method for the diagnosis of autoimmune thyroid diseases in liquidators.
Drygina
L B
LB
Alkhutova
N A
NA
Strukov
E L
EL
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis; D011210:Power Plants; D018788:Radioactive Hazard Release; D013959:Thyroid Diseases / Q000175:diagnosis*; D013961:Thyroid Gland / Q000276:immunology; D013997:Time Factors; D014455:Ukraine
D001323:Autoantibodies