title: Strontium is a potent and selective inhibitor of sensory irritation.
abstract: BACKGROUND
  Irritant contact dermatitis occurs following topical exposure to many chemicals found in cosmetics, personal care products, drugs, and during occupational exposure. Signs and symptoms may include sensory irritation (sting, burn, and/or itch), erythema, edema, and vesiculation.
  
  
  OBJECTIVE
  In an attempt to discover new classes of anti-irritant compounds without anesthetic properties, I observed that topical application of strontium salts to intact skin produced potent suppression of sting, burn, and itch caused by many irritant chemicals.
  
  
  METHODS
  Chemically and biologically unrelated irritants were applied with or without strontium salts to the skin of healthy women with self-reported sensitive skin in double-blind, vehicle-controlled, random-treatment assignment trials and sensory irritation was assessed.
  
  
  RESULTS
  Strontium application as a pretreatment or mixed with the irritant substantially suppressed sensory irritation without local anesthetic side-effects.
  
  
  CONCLUSIONS
  Strontium salts represent a new class of selective inhibitors of sensory irritation and irritant dermatitis.
authors.affiliation: Immunology and Allergy Division, Department of Pediatrics, University of California, San Diego, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Hahn
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D017453:Dermatitis, Irritant / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage*; D013324:Strontium / Q000008:administration & dosage*
chemical_list: D009566:Nitrates; C104873:strontium nitrate; C025700:strontium chloride; D013324:Strontium