title: Amphicrine tumor.
abstract: The term amphicrine refers to cells, and tumors, which show both exocrine and endocrine features. Author s aim was to analyse the characteristics of these neoplasms. 40 suspicious cases were reviewed. Mucin-stains (PAS, diastase-PAS, Stains-all, Alcian-blue), immunohistochemistry (antibodies against Neuron-Specific Enolase (NSE), and Chromogranin A (CGA), and electronmicroscopic studies were performed to demonstrate exocrine and/or endocrine features of the tumor cells. By means of these methods, 16 cases turned out to be amphicrine tumors. Among them, there were 4 sinonasal, 1 bronchial, 1 mediastinal, 8 gastrointestinal and 2 suprarenal gland neoplasms. In connection to the subject, a brief review is given of amphicrine tumor, regarding its etiological and pathological aspects. These tumors form a distinct clinicopathological entity and should be separated from both neuroendocrine tumors and adenocarcinomas.
authors.affiliation: Uzsoki Municipal Hospital, Department of Pathology, Uzsoki utca 29., Budapest, H-1145, Hungary. mandlasz@mail.matav.hu
authors.forename: L
authors.initials: L
authors.lastname: Mándoky
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000648:ultrastructure; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D001984:Bronchial Neoplasms / Q000473:pathology / Q000648:ultrastructure; D002276:Carcinoid Tumor / Q000175:diagnosis / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009077:Mucins / Q000032:analysis; D018193:Neoplasms, Complex and Mixed / Q000175:diagnosis* / Q000473:pathology* / Q000648:ultrastructure; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000648:ultrastructure
chemical_list: D009077:Mucins