title: Serial use of bedside CKMB/myoglobin device to detect acute myocardial infarction in emergency department chest pain patients.
abstract: A qualitative bedside device (Spectral Diagnostics, Toronto, Canada) for CKMB and myoglobin (MYOG) detection was evaluated in emergency department (ED) patients with chest pain to determine performance characteristics. At presentation (0 h) and at three hours (3 h), serum was analyzed in the ED with results considered positive if either 0-h or 3-h CKMB or MYOG bands were visible. The results were compared with the diagnosis of myocardial infarction (MI) per hospital discharge diagnosis (n = 132, 87%) or telephone follow-up (n = 19; 1 patient lost to follow-up). Of 151 study patients, 30 (20%) were diagnosed with MI; all were admitted to hospital. On electrocardiogram (EKG), 17 (57%) MI patients had ST-segment elevation. At 0-h, 26 of 30 (87%) MI patients were positive for CKMB/MYOG. By 3 h, 21 of 23 (91%) MI patients were positive for CKMB/MYOG; 7 MI patients were already admitted to hospital. Combining 0-h and 3-h results, the device sensitivity for MI was 93% (28/30) with specificity of 54%. Combining device results plus diagnostic EKG, sensitivity was found to be 100% (30/30). If the device result was positive, then the odds ratio for having an ischemic complication was 6.5. We conclude that the CKMB/MYOG device identified most MI patients at ED presentation and 3 h later. Combining device results with EKG detected all MI patients in the ED.
authors.affiliation: Highland Hospital, Oakland, California, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Young
authors.forename: P
authors.initials: P
authors.lastname: Murthi
authors.forename: M A
authors.initials: MA
authors.lastname: Levitt
authors.forename: Y
authors.initials: Y
authors.lastname: Gawad
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002637:Chest Pain / Q000175:diagnosis; D003402:Creatine Kinase / Q000097:blood*; D004562:Electrocardiography; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis*; D009211:Myoglobin / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase