Relationship of serum cholesterols and vitamin E to depressive status in the elderly.
Various relationships of serum cholesterols and alpha-tocopherol in the blood to depressive status as assessed by a short version of the Geriatric Depression Score (GDS) were cross-sectionally and longitudinally investigated in the elderly using multivariate analysis. Subjects comprised 504 residents (195 men and 309 women) aged 65 years and over in a rural community. Neither cholesterols nor alpha-tocopherol significantly related to depressive status in either sex, adjusted for age and educational attainment in cross-sectional analysis. However, both total cholesterol and alpha-tocopherol at baseline significantly prevented a 4-year longitudinal progression of depressive status in men alone, adjusted for age, education, and the GDS score at baseline. LDL + VLDL cholesterol related in the same fashion as total cholesterol, whereas HDL cholesterol did not significantly relate to the progression of depressive status.
Shibata
H
H
Department of Social Welfare, Tokyo Metropolitan Institute of Gerontology, Japan.
Kumagai
S
S
Watanabe
S
S
Suzuki
T
T
D000367:Age Factors; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003430:Cross-Sectional Studies; D003863:Depression / Q000145:classification* / Q000503:physiopathology; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D012423:Rural Health; D012737:Sex Factors; D014810:Vitamin E / Q000097:blood*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D014810:Vitamin E; D002784:Cholesterol