title: [Molecular biology of bladder cancer].
abstract: OBJECTIVE
  To analyze the factors that influence tumor progression and response to therapy.
  
  
  METHODS
  The new prognostic factors involved in the progression of bladder tumors that have been described in the literature, such as tumor antigen expression, molecular growth factors, cell adhesion molecules, oncogenes, tumor suppressor genes and mechanisms of tumor angiogenesis, are reviewed.
  
  
  CONCLUSIONS
  The etiopathogenesis of bladder cancer remains unknown and treatment is based on the clinical stage of the disease. The new tumor markers will permit a more individualized prognosis and treatment can be instituted according to the biological characteristics of the tumor.
authors.affiliation: Departamento de Urología, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
authors.forename: D
authors.initials: D
authors.lastname: Rosell Costa
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire
authors.forename: J E
authors.initials: JE
authors.lastname: Robles
authors.forename: J M
authors.initials: JM
authors.lastname: Berián Polo
mesh_terms: D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000473:pathology*