Autosome search for schizophrenia susceptibility genes in multiply affected families.
We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were distributed throughout the autosomes at an average spacing of 12.8 cM. The data were analysed with two-point linkage analysis (MLINK) and heterogeneity testing (HOMOG). Several genetic models were used ranging from near dominant to fully recessive. Multi-point analysis was performed for 27 regions demonstrating either contiguously positive lod scores in two or more consecutive markers, and in regions with two-point lod score(s) of 1.0 or above in a single marker. A proportion of the multi-point regions have been implicated in previous studies, thereby decreasing risk of false-positive results. However neither our two-point, nor multi-point scores reached the threshold value for significance of 3. 6. Nevertheless three regions were suggestive of linkage.
Rees
M I
MI
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK.
Fenton
I
I
Williams
N M
NM
Holmans
P
P
Norton
N
N
Cardno
A
A
Asherson
P
P
Spurlock
G
G
Roberts
E
E
Parfitt
E
E
Mant
R
R
Vallada
H
H
Dawson
E
E
Li
M W
MW
Collier
D A
DA
Powell
J F
JF
Nanko
S
S
Gill
M
M
McGuffin
P
P
Owen
M J
MJ
D002874:Chromosome Mapping / Q000379:methods; D004247:DNA / Q000097:blood; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers; D004247:DNA