Polyglutamine diseases: protein cleavage and aggregation.
Neuronal aggregates of the disease-causing protein, often in the nucleus of affected cells, are a pathological hallmark of the neurodegenerative diseases known as polyglutamine disorders. It was suggested that these nuclear aggregates are the cause of these disorders. However, recent evidence suggests that the aggregates, in fact, are not the pathogenic basis and, instead, may play a role in sequestration of the pathogenic protein.
Zoghbi
H Y
HY
Howard Hughes Medical Institute Baylor College of Medicine Houston, Texas 77030, USA. hzoghbi@bcms.tm.edu
Orr
H T
HT
D000818:Animals; D020169:Caspases / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry / Q000502:physiology*
D010455:Peptides; C097188:polyglutamine; D020169:Caspases