Interleukin-11: its biology and prospects for clinical use.
IL-11 is a multifunctional cytokine that has pleiotropic effects on a variety of tissue including the bone marrow and intestinal mucosa. IL-11 is useful in elevating the platelet count in cancer patients with chemotherapy-induced thrombocytopenia and has a cytoprotective effect on the bowel mucosa in a variety of causes of gut damage and a trophic effect on the villi after massive bowel resection.
Grosfeld
J L
JL
Department of Surgery, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Indianapolis, USA.
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Williams
D A
DA
D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D017370:Interleukin-11 / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000187:drug effects*; D010976:Platelet Count / Q000187:drug effects; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy
D017370:Interleukin-11