Genome screen for platelet monoamine oxidase (MAO) activity.
To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01: D6S1018 (p = 0.0004), D2S1328 (p = 0.008), and D2S408 (p = 0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N = 409) gave maximal lod scores of 2. 0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.
Saccone
N L
NL
Department of Psychiatry, Washington University, St. Louis, Missouri, USA. nlims@vodka.wustl.edu
Rice
J P
JP
Rochberg
N
N
Goate
A
A
Reich
T
T
Shears
S
S
Wu
W
W
Nurnberger
J I
JI
Foroud
T
T
Edenberg
H J
HJ
Li
T K
TK
D001792:Blood Platelets / Q000201:enzymology*; D002889:Chromosomes, Human, Pair 2; D002896:Chromosomes, Human, Pair 6; D005190:Family; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood* / Q000235:genetics*; D012907:Smoking
D005819:Genetic Markers; D008995:Monoamine Oxidase