Altered lipid peroxidation and antioxidant potential in human uterine tumors.
A comparative study of lipid peroxidation and antioxidant potential has been made in human uterus and uterine tumor. Two types of uterine tumor used are: tumor (I), a fibroid which is the commonest benign solid tumor in uterus and tumor (II), an adenomyoma. Tumor microsomes are less susceptible to lipid peroxidation induced by both enzymic (NADPH-ADP-Fe3+ and xanthine-xanthine-oxidase) and non-enzymic (ascorbate-Fe2+) systems except in the case of tumor (II) microsomes when induced with xanthine-xanthine oxidase. Resistance of tumor microsomes to lipid peroxidation is associated with the low content of substrates in the form of polyunsaturated fatty acids (PUFAs), higher level of alpha-tocopherol, reduced glutathione and protein thiols and altered enzymic antioxidant potential (catalase and superoxide dismutase).
Ray
S
S
Department of Chemistry, Bose Institute, Calcutta, India.
Chakrabarti
P
P
D000975:Antioxidants / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D014594:Uterine Neoplasms / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D005227:Fatty Acids; D014810:Vitamin E; D005978:Glutathione