[Role of adhesion molecules in the pathogenesis of COPD].
Recruitment and activation of inflammatory cells such as neutrophils, lymphocytes, and macrophages are important events in the pathogenesis of chronic obstructive pulmonary disease (COPD). Adhesion molecules play an central role in these processes. Several clinical investigations have demonstrated that the expression of ICAM-1 on the bronchial epithelium and E-selectin on bronchial mucosal vessels was increased in the patients with COPD. These findings suggested that adhesion molecules are involved in the pathogenesis of COPD.
Ishii
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Department of Pulmonary Medicine, Jichi Medical School.
D001980:Bronchi / Q000378:metabolism; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000502:physiology; D008173:Lung Diseases, Obstructive / Q000209:etiology* / Q000503:physiopathology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000502:physiology
D015815:Cell Adhesion Molecules