Sequential fast 3D MRI following oral ingestion of Gd-DOTA: A new means to assess intestinal transit time.
A magnetic resonance image (MRI)-based method to determine the colonic transit time is described. It is based on the oral ingestion of a single dose of 4 ml Gd-DOTA following an overnight fast and the subsequent acquisition of fast three-dimensional (3D) gradient-echo sequences under apnea conditions. The technique was successfully evaluated in three healthy volunteers. Transit of the contrast agent through the small and large intestines was easily followed. Thus, MRI-based colonic transit time determinations are feasible.
Patak
M A
MA
Institute of Diagnostic Radiology, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Weishaupt
D
D
Fröhlich
J M
JM
Debatin
J F
JF
D000284:Administration, Oral; D003287:Contrast Media / Q000008:administration & dosage*; D005772:Gastrointestinal Transit; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage*
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate