Reversible pancreatitis, hepatitis, and peripheral polyneuropathy associated with parenteral gold therapy.
A 63-year-old man with seronegative rheumatoid arthritis developed acute pancreatitis, severe hepatitis, and sensorimotor polyneuropathy after receiving 150 mg of intramuscular aurothioglucose (gold). Positive lymphocyte transformation test to gold indicated a cell mediated hypersensitivity to the drug, while multiple investigations ruled out other underlying causes for his illness. After cessation of gold therapy a complete recovery occurred.
Ben-Ami
H
H
Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel. mdhaim@tx.technion.ac.il
Pollack
S
S
Nagachandran
P
P
Lashevsky
I
I
Yarnitsky
D
D
Edoute
Y
Y
D000208:Acute Disease; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D017612:Gold Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012075:Remission, Spontaneous
D017612:Gold Compounds