title: Drosophila myc regulates cellular growth during development.
abstract: Transcription factors of the Myc proto-oncogene family promote cell division, but how they do this is poorly understood. Here we address the functions of Drosophila Myc (dMyc) during development. Using mosaic analysis in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size. dMyc-induced growth promotes G1/S progression but fails to accelerate cell division because G2/M progression is independently controlled by Cdc25/String. We also show that the secreted signal Wingless patterns growth in the wing primordium by modulating dMyc expression. Our results indicate that dMyc links patterning signals to cell division by regulating primary targets involved in cellular growth and metabolism.
authors.affiliation: Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Johnston
authors.forename: D A
authors.initials: DA
authors.lastname: Prober
authors.forename: B A
authors.initials: BA
authors.lastname: Edgar
authors.forename: R N
authors.initials: RN
authors.lastname: Eisenman
authors.forename: P
authors.initials: P
authors.lastname: Gallant
mesh_terms: D000483:Alleles; D000818:Animals; D001824:Body Constitution / Q000235:genetics; D019521:Body Patterning / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D048429:Cell Size / Q000235:genetics; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins; D005260:Female; D005328:Fetal Viability / Q000235:genetics; D007246:Infertility; D009030:Mosaicism; D009154:Mutation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C102284:Myc protein, Drosophila; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors