title: La Pitié heart transplantation: 30-year single center clinical experience.
abstract: At La Pitié Hospital, 1,184 patients underwent cardiac transplantation for end-stage cardiac disease (1,122 orthotopic and 62 heterotopic) between April 1968-November 1998. Since April 1986, 140 patients have been supported using several different mechanical assist devices as a bridge to transplantation. Twenty-four retransplantations (2.2%) were performed for primary graft failure in 4 (17%), refractory acute rejection in 7(29%), coronary graft disease in 11 (46%) and others in 2 (8%) patients. In a case-control study, retransplanted patients were matched with first transplant patients and survival rates at one and 5 years were 59.4% and 38.8% compared with survival rates for retransplanted patients of 45.4% and 31.2%, respectively. Seventy-four patients survived more than 10 years (61 males, 13 females). Mortality did not increase after 10 years. Unfortunately many suffered complications: 77% had hypertension, hypercholesterolemia (22%), hyperuricemia (41%), osteoporosis (11%), osteonecrosis (5%) and diabetes (7%). Renal function remains one of the main problems; 16% had a creatinine > 180 mumol/L and patients are on chronic dialysis.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, La Pitié Salpétrière Hospital, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Pavie
authors.forename: R
authors.initials: R
authors.lastname: Dorent
authors.forename: M
authors.initials: M
authors.lastname: Reagan
authors.forename: R
authors.initials: R
authors.lastname: Akthar
authors.forename: P
authors.initials: P
authors.lastname: Leger
authors.forename: E
authors.initials: E
authors.lastname: Vaissier
authors.forename: J P
authors.initials: JP
authors.lastname: Levasseur
authors.forename: V
authors.initials: V
authors.lastname: Bors
authors.forename: I
authors.initials: I
authors.lastname: Gandjbakhch
mesh_terms: D000206:Actuarial Analysis; D002410:Catholicism; D005260:Female; D006085:Graft Survival; D016027:Heart Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D016519:Hospitals, Religious / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D010297:Paris; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate