title: [Effect of total++ time of extracorporeal circulation in in myocardial revascularization surgery on urinary urea nitrogen loss].
abstract: Cardiopulmonary bypass probably should be an important factor increasing surgical stress when heart surgery is focused. This study was undertaken in order to evaluate the role of cardiopulmonary bypass in proteic catabolism. Study group consisted of patients who underwent cardiac aortic bypass graft as an isolated procedure. Inclusion criteria were elective surgery and absence of comorbidities after a rigorous preoperatory evaluation. One hundred and five patients were studied prospectively and urinary nitrogen loss was measured in the first 24 hour postoperative period. Operations performed were standard cardiopulmonary bypass procedures, under cardiopulmonary bypass, moderate hypothermia and hemodilution. Saphenous veins and mammary artery grafts were performed in all cases. Correlation and multiple linear regression were used. There was found no correlation between urinary nitrogen loss and age, gender and time under cardiopulmonary bypass. A positive correlation was found between number of grafts and increased urinary nitrogen loss. Further studies comparing cardiac aortic bypass graft with and without cardiopulmonary bypass are suggested.
authors.affiliation: Departamento de Cirurgia, Universidade Federal de São Paulo-UNIFESP-EPM.
authors.forename: C D
authors.initials: CD
authors.lastname: Magnoni
authors.forename: L E
authors.initials: LE
authors.lastname: Leão
authors.forename: C
authors.initials: C
authors.lastname: Cukier
authors.forename: R
authors.initials: R
authors.lastname: Giudici
mesh_terms: D000328:Adult; D000368:Aged; D005112:Extracorporeal Circulation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009584:Nitrogen / Q000652:urine*; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors; D014508:Urea / Q000652:urine*
chemical_list: D014508:Urea; D009584:Nitrogen