Trisomy 21 as the sole abnormality in a refractory anemia with ring sideroblasts.
Numerous chromosome abnormalities have been described in myelodysplastic syndromes, but single karyotypic aberrations are much less frequent. We report the case of a 65-year-old woman who presented a trisomy 21 as the sole karyotypic anomaly for a refractory anemia with ring sideroblasts. The nature of such an anomaly is discussed in regard to pathogenesis and prognosis.
Gancberg
D
D
Department of Pathology, CHU Saint-Pierre/ULB Institut Jules Bordet, Brussels, Belgium.
Kentos
A
A
Dargent
J L
JL
Roufosse
C
C
Dzota
G
G
Capel
P
P
Feremans
W
W
Verhest
A
A
D000368:Aged; D000756:Anemia, Sideroblastic / Q000235:genetics*; D001853:Bone Marrow / Q000473:pathology / Q000502:physiology; D004314:Down Syndrome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence