Proteolysis and cell migration: creating a path?
Both serine and metalloproteinases have been implicated in the complex integrated events underlying cell migration but no definitive single mechanism has emerged. Work over the past two years linking both membrane and soluble proteinases with integrins and other adhesion proteins and with intracellular signalling systems could herald the beginnings of a potential expansion of our understanding of the role and regulation of proteolysis in cell migration.
Murphy
G
G
School of Biological Sciences University of East Anglia Norwich, NR4 7TJ, UK. g.murphy@uea.ac.uk.
Gavrilovic
J
J
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000293:injuries; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005341:Fibrinolysin / Q000502:physiology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology; D008666:Metalloendopeptidases / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000502:physiology; D010010:Osteoclasts / Q000166:cytology; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000502:physiology; D055293:Receptors, Urokinase Plasminogen Activator; D012697:Serine Endopeptidases / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology
D016326:Extracellular Matrix Proteins; D009363:Neoplasm Proteins; C524898:PLAUR protein, human; C524899:Plaur protein, mouse; D011506:Proteins; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D010450:Endopeptidases; D012697:Serine Endopeptidases; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator; D008666:Metalloendopeptidases