title: [New therapies in neurology, but who benefits?].
abstract: In recent years several new treatments have been introduced in neurology, sumatriptan in migraine, riluzole in amyotrophic lateral sclerosis, interferon-beta in multiple sclerosis and rivastigmine in Alzheimer's disease. Doubts exist on the effects on functional outcome of these new treatments. Hardly effective drugs are not forced on physicians by the pharmaceutical industry, since physicians are involved in decisions from phase I studies to the final approval of the drugs. The problem is, however, that in clinical studies emphasis is still on statistically significant differences rather than on meaningful differences in the functional status of patients. In conclusion, in clinical studies outcome measures should be chosen more carefully and there is a need for sensitive linear functional scales.
authors.affiliation: Afd. Neurologie, Academisch Medisch Centrum, Amsterdam.
authors.forename: M
authors.initials: M
authors.lastname: Vermeulen
authors.forename: R J
authors.initials: RJ
authors.lastname: de Haan
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy; D000998:Antiviral Agents / Q000627:therapeutic use; D002219:Carbamates / Q000627:therapeutic use; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D008881:Migraine Disorders / Q000188:drug therapy; D009103:Multiple Sclerosis / Q000188:drug therapy; D009422:Nervous System Diseases / Q000188:drug therapy*; D009426:Netherlands; D018696:Neuroprotective Agents / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care / Q000379:methods*; D048448:Phenylcarbamates; D019782:Riluzole / Q000627:therapeutic use; D000068836:Rivastigmine; D018170:Sumatriptan / Q000627:therapeutic use; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D002219:Carbamates; D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D014662:Vasoconstrictor Agents; D016899:Interferon-beta; D019782:Riluzole; D018170:Sumatriptan; D000068836:Rivastigmine