High frequency of antibody activity against ribosomal protein S10 in anti-Sm sera from patients with systemic lupus erythematosus.
This study was carried out to clarify the frequency of detection of antibody activity to ribosomal protein S10 (anti-S10) in patients with systemic lupus erythematosus (SLE) with anti-Sm antibodies (anti-Sm), and clinical differences between anti-Sm-positive SLE patients with and without anti-S10. Twenty-seven of 31 serum samples containing anti-Sm reacted with ribosomal protein S10 along with Sm core proteins B/B' and D (87.1%). Four serum samples containing anti-Sm against only B/B' but not D did not react with S10 (12.9%). Patients who had both anti-Sm and anti-S10 showed lower serum complements levels, high frequency of skin lesion and anti-double-stranded DNA antibody. Many anti-Sm antibodies may recognize B/B', D, and S10 simultaneously, and such antibodies may appear in active disease.
Hasegawa
H
H
Department of Medicine (II), Niigata University School of Medicine, Asahimachi Dori 1-757, Niigata 951-8510, Japan.
Uchiumi
T
T
Sato
T
T
Ofuchi
Y
Y
Murakami
S
S
Honda
S
S
Hirose
S
S
Ito
S
S
Nakano
M
M
Arakawa
M
M
Gejyo
F
F
D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D017411:Ribonucleoproteins, Small Nuclear / Q000276:immunology; D012269:Ribosomal Proteins / Q000276:immunology*; D055517:snRNP Core Proteins
D001323:Autoantibodies; D001324:Autoantigens; D017411:Ribonucleoproteins, Small Nuclear; D012269:Ribosomal Proteins; C029537:ribosomal protein S10; D055517:snRNP Core Proteins