Polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in patients with rheumatoid arthritis.
Polymorphisms in the 5'-flanking promoter/enhancer region of the tumor necrosis factor (TNF)-a gene were examined to study the genetic background of rheumatoid arthritis (RA). Four variant alleles, -1,031C/ -863A, -1,031C/-238A, -857T and -308A, were identified and examined in 387 RA patients and 575 healthy Japanese controls. The frequency of the -857T allele in RA patients was significantly higher than that in the controls. However, the HLA-DRB1 analysis in the same subjects showed that the DRB1*0405 allele, which is in linkage disequilibrium with the -857T, was more strongly associated with the disease susceptibility than the -857T allele. These results suggest that the susceptible gene to RA is more closely linked to the HLA-DRB1 locus than to the TNF-alpha locus.
Seki
N
N
Department of Immunology, Kurume University School of Medicine, Japan.
Kamizono
S
S
Yamada
A
A
Higuchi
T
T
Matsumoto
H
H
Niiya
F
F
Kimura
A
A
Tsuchiya
K
K
Suzuki
R
R
Date
Y
Y
Tomita
T
T
Itoh
K
K
Ochi
T
T
D020121:5' Untranslated Regions / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D011110:Polymorphism, Genetic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D020121:5' Untranslated Regions; D014409:Tumor Necrosis Factor-alpha