title: HLA-DMA and HLA-DMB genotyping in patients with systemic lupus erythematosus.
abstract: OBJECTIVE. To investigate the relation of HLA-DMA and DMB alleles to the development of systemic lupus erythematosus (SLE).
  
  
  METHODS
  We studied HLA-DMA and DMB alleles in 108 patients with SLE and 138 healthy controls using the amplification created restriction site method.
  
  
  RESULTS
  The phenotypic frequency of HLA-DMA*0104 was significantly higher in patients with SLE than in healthy controls. The HLA-DMA and DMB alleles were not related to clinical manifestations and various laboratory tests in patients with SLE.
  
  
  CONCLUSIONS
  HLA-DMA*0104 may be associated with the susceptibility of SLE.
authors.affiliation: Department of Internal Medicine, Kaohsiung Medical College, Taiwan.
authors.forename: J H
authors.initials: JH
authors.lastname: Yen
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: W C
authors.initials: WC
authors.lastname: Tsai
authors.forename: J J
authors.initials: JJ
authors.lastname: Tsai
authors.forename: T T
authors.initials: TT
authors.lastname: Ou
authors.forename: H W
authors.initials: HW
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006681:HLA-D Antigens / Q000032:analysis*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013624:Taiwan
chemical_list: D005819:Genetic Markers; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II