Plasma lipids and stroke.
High plasma levels of lipids are an important modifiable risk factor for coronary heart disease, but are not established as a risk factor for stroke. Pathophysiologic evidence that links lipids to major systemic artery disease, and the results of clinical trials of coronary heart disease prevention in relation to lipid-lowering suggest that lipids may play an important role in the causation of stroke. We discuss the controversy concerning plasma lipids as a risk factor for stroke. A clinical trial targeted at lowering levels of lipids with the aim of primary stroke prevention would be a timely and important contribution. Armed with this information, we could further clarify the plasma lipid-stroke controversy and move into the 21st century with a better understanding of stroke prevention.
Gorelick
P B
PB
Department of Neurological Sciences, Center for Stroke Research, Rush Medical College and Rush Medical Center, Chicago, Illinois, USA.
Mazzone
T
T
D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications* / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D015994:Incidence; D008055:Lipids / Q000097:blood*; D011322:Primary Prevention; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D015996:Survival Rate
D000960:Hypolipidemic Agents; D008055:Lipids