title: [Influence of postoperative topical application of miotics after cataract extraction on intraocular pressure and the blood-aqueous barrier].
abstract: BACKGROUND
  In the present study we evaluated the influence of topical miotics on intraocular pressure and the blood-aqueous barrier after uncomplicated phacoemulsification and PC-IOL implantation.
  
  
  METHODS
  Fifty-two eyes were randomized into 2 groups: with miotics (n = 28) and without miotics (n = 24). The IOP was measured before, 6 h, 1 and 2 days after surgery. Measurement of aqueous flare was performed before and on days 1 and 2 after surgery. Patients with glaucoma, PEX or previous intraocular surgery were excluded.
  
  
  RESULTS
  In the group without miotics the IOP was 17.9 mm Hg (+/- 3.34) 6 h postoperatively; in the second group it was 15.5 mm Hg (+/- 3.25); P = 0.04. On the first postoperative day the IOP measured in the group without miotics was 15.3 mm Hg (+/- 2.70) and with miotics 13.0 mm Hg (+/- 2. 28); P = 0.007. On the second day in the group without miotics the IOP was 13.9 mm Hg (+/- 3.05) and with miotics 12.60 mm Hg (+/- 2. 19); P = 0.53. The changes in aqueous flare on the first and second day after surgery showed no significant influence of miotics on the blood-aqueous barrier (P > 0.05).
  
  
  CONCLUSIONS
  Immediate postoperative application of topical miotics led to a small yet significant reduction of the IOP during the first 24 h after surgery. Our data suggest that there is no need for pharmacological reduction of the IOP after uncomplicated cataract surgery.
authors.affiliation: Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
authors.forename: I
authors.initials: I
authors.lastname: Tomida
authors.forename: P
authors.initials: P
authors.lastname: Martus
authors.forename: M
authors.initials: M
authors.lastname: Küchle
mesh_terms: D018916:Blood-Aqueous Barrier / Q000187:drug effects*; D002217:Carbachol / Q000008:administration & dosage* / Q000009:adverse effects; D002387:Cataract Extraction; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007910:Lenses, Intraocular; D008916:Miotics / Q000008:administration & dosage* / Q000009:adverse effects; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage* / Q000009:adverse effects; D011182:Postoperative Care
chemical_list: D008916:Miotics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D002217:Carbachol