[Elastase anti-elastase imbalance in the pathogenesis of COPD].
Elastase anti-elastase imbalance theory is most important in the pathogenesis of COPD (pulmonary emphysema). Proteolytic activity of neutrophil elastase (NE) plays an important role because of the detachment of cells through proteolysis of extracellular matrix. In addition to proteolytic activity of NE, NE-induced activation of intracellular signaling (MAPK(Erk), Rho and MLCK) participates in NE-induced morphological changes in airway epithelial cells.
Maruoka
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First Department of Internal Medicine, Nihon University School of Medicine.
Hashimoto
S
S
D018450:Disease Progression; D004847:Epithelial Cells; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D019272:Leukocyte Elastase / Q000378:metabolism* / Q000502:physiology; D008168:Lung / Q000166:cytology; D008173:Lung Diseases, Obstructive / Q000209:etiology*; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D054460:rho-Associated Kinases
D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases; D009219:Myosin-Light-Chain Kinase; D020929:Mitogen-Activated Protein Kinase Kinases; D019272:Leukocyte Elastase