title: Oral and topical antibiotic therapy of complete, primary acquired nasolacrimal duct obstruction in adults.
abstract: OBJECTIVE
  To determine whether patients with complete, acquired nasolacrimal duct obstruction may be treated with broad spectrum oral antibiotics and office lacrimal irrigation.
  
  
  METHODS
  In a retrospective review, patients with complete, primary acquired nasolacrimal duct obstruction (NLDO) were divided by predominant symptoms and signs into two main groups: (a) those with tearing and/or mucous discharge and (b) those with previous acute dacryocystitis and/or lacrimal sac mucocele. All patients received a therapeutic trial of oral and topical antibiotics followed by lacrimal irrigation.
  
  
  RESULTS
  Five of 55 patients with tearing and/or mucous discharge showed significant improvement after treatment with a mean follow-up of 16.5 months. A sixth patient with mucous and tearing had resolution of the mucous discharge but persistent tearing and blockage of the nasolacrimal system to irrigation. Two of 20 patients with lacrimal sac mucocele or history of acute dacryocystitis avoided surgery while 18 opted for early lacrimal surgical intervention.
  
  
  CONCLUSIONS
  Conservative management of complete acquired NLDO consisting of oral and topical antibiotics and appropriately timed office lacrimal drainage system irrigation may be considered in selected patients.
authors.affiliation: Department of Ophthalmology, UMD-New Jersey Medical School, Newark, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Mauriello
authors.forename: C
authors.initials: C
authors.lastname: Guzman
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents; D003607:Dacryocystitis / Q000209:etiology / Q000517:prevention & control; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000150:complications / Q000188:drug therapy*; D009078:Mucocele / Q000209:etiology / Q000517:prevention & control; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents