Regional variation in the histological appearance of the small and large intestine of the rat following acute and chronic administration of Melo's Conquer Mixture.
The effect of acute and chronic administration of various doses of Melo's Conquer Mixture (MCM) on the histological appearance of the small and large intestine was investigated in albino Wistar rats. Obtained results show that at recommended therapeutic dose, MCM is able to evoke an acute inflammatory response, with infiltration of the mucosa and submucosa by neutrophils, lymphocytes and eosinophils. In addition, there was submucosal lymphoid follicle hyperplasia and increased mucus secreting cells. The severity of these changes were dependent more on prolonged administration than dose. These findings suggest strongly that MCM is a potential toxic agent. We therefore recommend further chemical analysis to identify the possible toxic agent(s) in this mixture.
Didia
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BC
Department of Anatomy and Human Physiology, College of Health Sciences, University of Port Harcourt, Nigeria.
Dapper
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DV
D000818:Animals; D002400:Cathartics / Q000009:adverse effects*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D006965:Hyperplasia; D007079:Ileitis / Q000139:chemically induced* / Q000473:pathology*; D007420:Intestine, Large / Q000187:drug effects* / Q000473:pathology*; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology*; D008278:Magnesium Sulfate / Q000009:adverse effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D031955:Rhamnus / Q000009:adverse effects*; D013997:Time Factors
D002400:Cathartics; D004338:Drug Combinations; D008278:Magnesium Sulfate