title: IL1HY1: A novel interleukin-1 receptor antagonist gene.
abstract: Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%. The gene was mapped to the long arm of chromosome 2, in close proximity to the IL-1 locus. IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types. Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment.
authors.affiliation: Functional Genomics Department, Immunology Group, Hyseq Inc., 670 Almanor Avenue, Sunnyvale, California 94086, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Mulero
authors.forename: A M
authors.initials: AM
authors.lastname: Pace
authors.forename: S T
authors.initials: ST
authors.lastname: Nelken
authors.forename: D B
authors.initials: DB
authors.lastname: Loeb
authors.forename: T R
authors.initials: TR
authors.lastname: Correa
authors.forename: R
authors.initials: R
authors.lastname: Drmanac
authors.forename: J E
authors.initials: JE
authors.lastname: Ford
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001921:Brain / Q000276:immunology; D002460:Cell Line; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005333:Fetus; D005784:Gene Amplification; D015723:Gene Library; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007378:Interleukins; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008969:Molecular Sequence Data; D005810:Multigene Family; D009928:Organ Specificity; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012795:Sialoglycoproteins / Q000737:chemistry / Q000235:genetics; D012867:Skin / Q000196:embryology / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014158:Transcription, Genetic
chemical_list: C507763:IL1RN protein, human; C122187:IL36RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007378:Interleukins; D011506:Proteins; D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins