Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coli.
Enteropathogenic Escherichia coli (EPEC) was found to exhibit a type III secretion-dependent, contact-mediated, hemolytic activity requiring the EspA, EspB, and EspD secreted proteins. EspB and EspD display homology to pore-forming molecules. Our data suggest a mechanism to explain the requirement for all three Esp proteins in the transfer of EPEC proteins, such as Tir, into target cells.
Warawa
J
J
Department of Pathology and Microbiology, School of Medical Sciences, Bristol, England.
Finlay
B B
BB
Kenny
B
B
D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology*; D001426:Bacterial Proteins / Q000502:physiology*; D004926:Escherichia coli / Q000472:pathogenicity*; D029968:Escherichia coli Proteins; D006461:Hemolysis; D008565:Membrane Proteins / Q000502:physiology*; D008969:Molecular Sequence Data; D012756:Sheep
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins; C102051:EspA protein, E coli; C474481:EspD protein, E coli; D008565:Membrane Proteins