[Nucleic acid syntheses and molecular recognition].
Syntheses of nucleic acids are of importance not only in the natural product chemistry but also in the molecular recognition study in biology. This review describes syntheses of RNA and DNA, which were found to be related each other. Deoxyinosine probes were developed for cloning genes with degenerated codons. Synthetic genes for c-Ha-ras and T4 endonuclease V provided new approaches in recognition of nucleic acids by proteins. Antibodies specific for photo-damaged pyrimidines in DNA have been studied by cloning and mutating their genes.
Ohtsuka
E
E
Health Sciences University of Hokkaido, Japan.
D004247:DNA / Q000138:chemical synthesis*; D004249:DNA Damage; D015342:DNA Probes; D004260:DNA Repair; D043224:Deoxyribonuclease (Pyrimidine Dimer); D004706:Endodeoxyribonucleases; D020868:Gene Silencing; D011905:Genes, ras / Q000235:genetics; D007288:Inosine / Q000031:analogs & derivatives; D009154:Mutation; D012313:RNA / Q000138:chemical synthesis*; D016337:RNA, Catalytic; D014764:Viral Proteins
D015342:DNA Probes; D016337:RNA, Catalytic; D014764:Viral Proteins; D007288:Inosine; D012313:RNA; D004247:DNA; D004706:Endodeoxyribonucleases; C470698:endonuclease V, phage T4; D043224:Deoxyribonuclease (Pyrimidine Dimer); C012271:deoxyinosine