Association of urinary leukotriene E4 excretion during aspirin challenges with severity of respiratory responses.
BACKGROUND
Asthmatics with aspirin- (ASA) sensitive respiratory disease (ASRD) have a spectrum of respiratory reactions during oral ASA challenge that vary in severity and are temporally associated with leukotriene (LT) formation.


OBJECTIVE
This study investigates the relationship of the severity of ASA-induced respiratory reactions to urinary LTE(4) excretion.


METHODS
Asthmatics with suspected ASRD underwent oral ASA challenges. Urinary LTE(4) levels were measured at baseline, during the reaction, and after acute ASA desensitization.


RESULTS
Asthmatics who had respiratory reactions during oral ASA challenges were divided into 3 groups: asthmatics with naso-ocular reactions and <15% decline from baseline FEV(1) values (group 1), asthmatics with a decline in FEV(1) of 20% to 30% (group 2), and asthmatics with a decline in FEV(1) of >30% (group 3). There were no significant differences in age, baseline FEV(1) values, use of inhaled corticosteroids, daily prednisone doses, prednisone bursts, duration of reactions, or average provoking doses of ASA among the groups. At baseline group 3 asthmatics had significantly higher urinary LTE(4) levels than those in groups 1 or 2. At the time of respiratory reaction to ASA, the urinary LTE(4) levels rose significantly in all groups but were significantly greater among group 3 asthmatics compared with those in groups 1 and 2.


CONCLUSIONS
The severity of the respiratory reactions during oral ASA challenges was associated with the degree of elevation of baseline LTE(4) synthesis. Our results suggest that asthmatics with ASRD have a spectrum of respiratory tract reactions in which leukotrienes play a distinguishing role.
Daffern
P J
PJ
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
Muilenburg
D
D
Hugli
T E
TE
Stevenson
D D
DD
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000503:physiopathology / Q000652:urine*; D004342:Drug Hypersensitivity / Q000503:physiopathology / Q000652:urine*; D006801:Humans; D017999:Leukotriene E4 / Q000652:urine*; D008875:Middle Aged
D017999:Leukotriene E4; D001241:Aspirin