title: Application of a self-reinforced polyglycolic acid (SR-PGA) membrane to the closure of an abdominal fascial defect in rats.
abstract: The suitability of a polyglycolic acid (PGA) membrane to fascial closure was tested in 40 rats. To induce collagen synthesis, a fascial strip from the vastus lateralis muscle was applied to the peritoneal side of the PGA membrane. A midline laparotomy was performed, and the incision was covered with the membrane fixed at the edges. The animals were sacrificed at 3, 6, 12, and 28 weeks, at which time macroscopical, histological, and electron microscopical findings, as well as the results of breaking force tests were evaluated. Fascial augmentation had no effect on the results. Ventral hernias were observed in 37.5% of the cases, half of which were observed after 6 weeks postoperatively. In one case, intestinal adhesions to the membrane were found. Inflammatory reaction during the follow-up was moderate and lasted up to 12 weeks. Breaking force decreased up to 6 weeks, after which it slightly increased without reaching the breaking force level of the control animals.
authors.affiliation: Department of Surgery, Kuopio University Hospital, Kuopio, Finland. Antero.Heino@kuh.fi
authors.forename: A
authors.initials: A
authors.lastname: Heino
authors.forename: A
authors.initials: A
authors.lastname: Naukkarinen
authors.forename: T
authors.initials: T
authors.lastname: Pietiläinen
authors.forename: M E
authors.initials: ME
authors.lastname: Merasto
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: T
authors.initials: T
authors.lastname: Pohjonen
authors.forename: E A
authors.initials: EA
authors.lastname: Mäkelä
mesh_terms: D000007:Abdominal Injuries / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D000071938:Fasciotomy; D008297:Male; D008855:Microscopy, Electron, Scanning; D011100:Polyglycolic Acid; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid