title: Comparison of intensity-modulated tomotherapy with stereotactically guided conformal radiotherapy for brain tumors.
abstract: OBJECTIVE
  Intensity-modulated radiotherapy (IMRT) offers the potential to more closely conform dose distributions to the target, and spare organs at risk (OAR). Its clinical value is still being defined. The present study aims to compare IMRT with stereotactically guided conformal radiotherapy (SCRT) for patients with medium size convex-shaped brain tumors.
  
  
  METHODS
  Five patients planned with SCRT were replanned with the IMRT-tomotherapy method using the Peacock system (Nomos Corporation). The planning target volume (PTV) and relevant OAR were assessed, and compared relative to SCRT plans using dose statistics, dose-volume histograms (DVH), and the Radiation Therapy Oncology Group (RTOG) stereotactic radiosurgery criteria.
  
  
  RESULTS
  The median and mean PTV were 78 cm3 and 85 cm3 respectively (range 62-119 cm3). The differences in PTV doses for the whole group (Peacock-SCRT +/-1 SD) were 2%+/-1.8 (minimum PTV), and 0.1%+/-1.9 (maximum PTV). The PTV homogeneity achieved by Peacock was 12.1%+/-1.7 compared to 13.9%+/-1.3 with SCRT. Using RTOG guidelines, Peacock plans provided acceptable PTV coverage for all 5/5 plans compared to minor coverage deviations in 4/5 SCRT plans; acceptable homogeneity index for both plans (Peacock = 1.1 vs. SCRT = 1.2); and comparable conformity index (1.4 each). As a consequence of the transaxial method of arc delivery, the optic nerves received mean and maximum doses that were 11.1 to 11.6%, and 10.3 to 15.2% higher respectively with Peacock plan. The maximum optic lens, and brainstem dose were 3.1 to 4.8% higher, and 0.6% lower respectively with Peacock plan. However, all doses remained below the tolerance threshold (5 Gy for lens, and 50 Gy for optic nerves) and were clinically acceptable.
  
  
  CONCLUSIONS
  The Peacock method provided improved PTV coverage, albeit small, in this group of convex tumors. Although the OAR doses were higher using the Peacock plans, all doses remained within the clinically defined threshold and were clinically acceptable. Further improvements may be expected using other methods of IMRT planning that do not limit the treatment delivery to transaxial arcs. Each IMRT system needs to be individually assessed as the paradigm utilized may provide different outcomes.
authors.affiliation: Neuro-oncology Unit, The Institute of Cancer Research and the Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom.
authors.forename: V S
authors.initials: VS
authors.lastname: Khoo
authors.forename: M
authors.initials: M
authors.lastname: Oldham
authors.forename: E J
authors.initials: EJ
authors.lastname: Adams
authors.forename: J L
authors.initials: JL
authors.lastname: Bedford
authors.forename: S
authors.initials: S
authors.lastname: Webb
authors.forename: M
authors.initials: M
authors.lastname: Brada
mesh_terms: D000465:Algorithms; D001254:Astrocytoma / Q000601:surgery; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D002421:Caudate Nucleus; D003390:Cranial Nerve Neoplasms / Q000601:surgery; D005910:Glioma / Q000601:surgery; D006801:Humans; D008577:Meningeal Neoplasms / Q000601:surgery; D008579:Meningioma / Q000601:surgery; D009897:Optic Chiasm; D016634:Radiosurgery / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*