title: Patterns of macrolide resistance determinants among community-acquired Streptococcus pneumoniae isolates over a 5-year period of decreased macrolide susceptibility rates.
abstract: Erythromycin resistance rates were found to be increased, from 7.1 in 1993 to 32.8% in 1997, among community-acquired Streptococcus pneumoniae isolates from the Siena area of central Italy. Most of the erythromycin-resistant isolates carried ermAM determinants and were also resistant to josamycin and clindamycin, whereas a minority (5.8%) carried mefA determinants and remained susceptible to the latter drugs.
authors.affiliation: Istituto di Clinica delle Malattie Infettive, Sezione di Microbiologia, Università di Siena, 53100-Siena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Oster
authors.forename: A
authors.initials: A
authors.lastname: Zanchi
authors.forename: S
authors.initials: S
authors.lastname: Cresti
authors.forename: M
authors.initials: M
authors.lastname: Lattanzi
authors.forename: F
authors.initials: F
authors.lastname: Montagnani
authors.forename: C
authors.initials: C
authors.lastname: Cellesi
authors.forename: G M
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017714:Community-Acquired Infections; D004352:Drug Resistance, Microbial / Q000502:physiology; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007558:Italy; D008826:Microbial Sensitivity Tests; D011018:Pneumonia, Pneumococcal / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin