Combinatorial search of substituted beta-cyclodextrins for phosphatase-like activity.
Thirteen per-6-akylamino-6-deoxy-beta-cyclodextrin libraries (beta-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-beta-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyzep-nitrophenyl phosphate in the presence of Zn2+.
Yu
J
J
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 60612, USA.
Zhao
Y
Y
Holterman
M J
MJ
Venton
D L
DL
D020650:Combinatorial Chemistry Techniques; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D013058:Mass Spectrometry; D015394:Molecular Structure; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010744:Phosphoric Monoester Hydrolases; C031215:betadex