Y-chromosomal DNA haplotype differences in control and infertile Italian subpopulations.
Y-chromosomal DNA haplotypes were determined in 74 infertile and 216 control Italian males using eight biallelic markers. A significant difference in haplotype frequency was found, but could be explained by the geographical origins of the samples. The Y chromosome is thus a sensitive marker for population substructuring and may be useful for determining whether two population samples come from a single population, for example in association studies.
Previderé
C
C
CRC Chromosome Molecular Biology Group, Department of Biochemistry, University of Oxford, UK.
Stuppia
L
L
Gatta
V
V
Fattorini
P
P
Palka
G
G
Tyler-Smith
C
C
D016022:Case-Control Studies; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D008297:Male; D008957:Models, Genetic; D005810:Multigene Family; D013094:Spermatozoa / Q000002:abnormalities; D014998:Y Chromosome
D005819:Genetic Markers