Myocardial uptake of technetium-99m-furifosmin (Q12) versus technetium-99m-sestamibi (MIBI).
OBJECTIVE
This study was performed to compare the myocardial uptake of Tc-99m-furifosmin (Q12) versus Tc-99m-sestamibi (MIBI) in correlation to the whole-body uptake under resting conditions.


METHODS
21 patients with coronary artery disease and no rest ischemia were examined. A whole-body scan was performed 60 min. p.i. under resting conditions. A quantification of the uptake (whole-body, heart and right lung) was done by ROI technique.


RESULTS
The heart-to-lung ratio of Q12 (1.56 +/- 0.191) was significantly lower as compared to MIBI (1.94 +/- 0.197; p < 0.01). In contrast, the heart-to-whole-body ratios (Q12 versus MIBI: 0.027 +/- 0.012 versus 0.026 +/- 0.004; p < 0.76) did not differ. The lung-to-whole-body ratio (Q12 versus MIBI: 0.018 +/- 0.009 versus 0.013 +/- 0.002; p < 0.17) were different, but did not reach significance.


CONCLUSIONS
These data show that under resting conditions the total myocardial uptake of Q12 does not differ significantly from that of MIBI. However, the pulmonary uptake of Q12 is slightly higher, resulting in a significant lower heart-to-lung ratio. These findings imply a lower image quality of Q12 compared to MIBI.
Bangard
M
M
Klinik für Nuklearmedizin, Universitätsklinik Bonn, Deutschland. bangard@mailer.meb.uni-bonn.de
Bender
H
H
Grünwald
F
F
Hümmelgen
M
M
Willkomm
P
P
Palmedo
H
H
Lüderitz
B
B
Biersack
H J
HJ
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D005663:Furans / Q000493:pharmacokinetics*; D015902:Gamma Cameras; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D005663:Furans; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078496:technetium Tc 99m Q12; D017256:Technetium Tc 99m Sestamibi