title: Serum markers of brain damage and outcome prediction in patients after severe head injury.
abstract: The objective of the study was to investigate the validity of outcome prediction after severe head injury using serum levels of S-100B protein and neuron specific enolase. Eighty-two patients with severe head injury were included in this prospective study. Venous blood samples were taken after admission and every 24 h for a maximum of 10 consecutive days. For values of S-100 from 0 to 2.5 micrograms/l, and for values of NSE from 0 to 100 micrograms/l the sensitivity and specificity of incremental values as a predictor of unfavourable outcome were calculated and Receiver Operator Characteristics curves were plotted. Serum S-100 protein was found to be clearly superior to neuron specific enolase in terms of predicting outcome with higher specificity, sensitivity, positive and negative predictive value. According to our experience, S-100B protein represents the most promising serum marker of brain cell damage currently under investigation.
authors.affiliation: Department of Neurosurgery, University of Leipzig, Germany. araa@medizin-uni-leipzig.de
authors.forename: A
authors.initials: A
authors.lastname: Raabe
authors.forename: C
authors.initials: C
authors.lastname: Grolms
authors.forename: V
authors.initials: V
authors.lastname: Seifert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001925:Brain Damage, Chronic / Q000097:blood / Q000175:diagnosis*; D006259:Craniocerebral Trauma / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011446:Prospective Studies; D009418:S100 Proteins / Q000097:blood; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase