title: Genomics for food biotechnology: prospects of the use of high-throughput technologies for the improvement of food microorganisms.
abstract: Functional genomics is currently the most effective approach for increasing the knowledge at the molecular level of metabolic and adaptive processes in whole cells. High-throughput technologies, such as DNA microarrays, and improved two-dimensional electrophoresis methods combined with tandem mass-spectroscopy, supported by bioinformatics, are useful tools for food biotechnology, which depends on detailed knowledge of the properties of food microbes (and pathogens) in their industrial, food and consumer environments. Genomics of food microbes, based on rapidly emerging genome sequence information, generates valuable knowledge that can be used for metabolic engineering, improving cell factories and development of novel preservation methods. Furthermore, pre- and probiotic studies, characterization of stress responses, studies of microbial ecology and, last but not least, development of novel risk assessment procedures will be facilitated.
authors.affiliation: Department of Genetics Groningen Biomolecular Sciences and Biotechnology Institute University of Groningen PO Box 14, 9750 AA, Haren, The Netherlands. o.p.kuipers@biol.rug.nl
authors.forename: O P
authors.initials: OP
authors.lastname: Kuipers
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology; D005516:Food Microbiology; D005524:Food Technology / Q000379:methods* / Q000639:trends; D005544:Forecasting; D015964:Gene Expression Regulation, Bacterial; D005821:Genetic Techniques; D019344:Lactic Acid / Q000378:metabolism; D017045:Lactococcus / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins; D019344:Lactic Acid