Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects.
Piperazine derivatives were prepared as histamine antagonists. Some of the synthesized compounds showed dual antagonistic activity against bradykinin as well as histamine.
Choo
H Y
HY
School of Pharmacy, Ewha Womans University, Seoul, Korea.
Chung
B J
BJ
Chung
S H
SH
D000818:Animals; D065168:Bradykinin Receptor Antagonists; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats
D065168:Bradykinin Receptor Antagonists; D006634:Histamine H1 Antagonists; D010879:Piperazines