title: Synthesis and in vitro antibacterial activity of C-3' pyridinium cephalosporin derivatives.
abstract: The quaternary ammonium cephalosporin derivatives were prepared with various pyridines substituted at the 3 or/and 4 position. Their in vitro antibacterial activities were determined and substituent effect on pyridine nucleus was studied. Preparation of substituted pyridines are also described.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Seoul. inchung@kistmail.kist.re.kr
authors.forename: I H
authors.initials: IH
authors.lastname: Chung
authors.forename: C S
authors.initials: CS
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Seo
authors.forename: B Y
authors.initials: BY
authors.lastname: Chung
mesh_terms: D001419:Bacteria / Q000187:drug effects; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; D011726:Pyridinium Compounds