title: [Peritonitis models in the rat with special reference to laparoscopic therapy options].
abstract: With ongoing development of minimally invasive surgery the laparoscopic techniques are increasingly used also in patients with intra-abdominal inflammatory diseases. The systemic sequelae of laparoscopy are not yet clear. In this study, we investigated three experimental models of peritonitis in rats (cecal ligation and puncture n = 14, cecal stent peritonitis n = 14, implantation of a standardized fecal inoculum n = 18) concerning the therapeutic potential of laparoscopy, reproducibility of the results and clinical relevance (elimination of the inflammatory focus, intraperitoneal modulation of inflammation). The peritonitis model of implantation of a standardized fecal inoculum was shown to be the experimental model with the closest clinical relevance. In this technically simple, reproducible model, the primary inflammatory focus can be eliminated by laparoscopic lavage. A significant difference (p < 0.002) of survival between the groups with and without laparoscopic lavage was found. In addition, the intraperitoneal application of drugs is possible in order to modulate peritoneal and systemic inflammation.
authors.affiliation: Klinik für Chirurgie, Otto-von-Guericke Universität Magdeburg.
authors.forename: M
authors.initials: M
authors.lastname: Pross
authors.forename: H U
authors.initials: HU
authors.lastname: Schulz
authors.forename: T
authors.initials: T
authors.lastname: Manger
authors.forename: D
authors.initials: D
authors.lastname: Kunz
authors.forename: R
authors.initials: R
authors.lastname: Mantke
authors.forename: W
authors.initials: W
authors.lastname: Halangk
authors.forename: H
authors.initials: H
authors.lastname: Lippert
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D004195:Disease Models, Animal; D006801:Humans; D007416:Intestinal Perforation / Q000473:pathology / Q000601:surgery; D010535:Laparoscopy; D008297:Male; D019060:Minimally Invasive Surgical Procedures; D010529:Peritoneal Cavity / Q000473:pathology; D010538:Peritonitis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome