Synthesis and antitumour activity of novel diterpenequinone salvicine and the analogs.
A novel diterpenequinone named salvicine (4), structurally modified derivative of a natural product, and a series of the novel analogs have been prepared. Most of the analogs were found to be potently active against tumor cell lines in vitro. Further study on 4 in vivo demonstrated that it possessed a significant antineoplastic activity against murine S-180 Sarcoma and Lewis lung cancer, and human lung adenocarcinoma xenografts A-549 and LAX-83. The preclinical studies of 4 are now under way.
Zhang
J S
JS
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, People's Republic of China. jszhang@mail.shcnc.ac.cn
Ding
J
J
Tang
Q M
QM
Li
M
M
Zhao
M
M
Lu
L J
LJ
Chen
L J
LJ
Yuan
S T
ST
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; C122096:salvicine