Peripheral neuropathy in healthy men volunteers anesthetized with 1.25 MAC sevoflurane for 8 hours.
Two men volunteers developed peripheral neuropathy after prolonged anesthesia with 1.25 minimum alveolar concentration sevoflurane at an inflow rate of 2 L/minute of fresh gas that caused concurrent administration of relatively large doses (ppm-hrs) of the degradation product of sevoflurane, compound A. Other similarly treated volunteers had lesser degrees of transient neuropathy. This result does not prove but raises the question of whether compound A or other factors associated with sevoflurane anesthesia can predispose patients to peripheral neuropathy.
Goldberg
M E
ME
Department of Anesthesiology, Cooper Health Systems, University of Medicine and Dentistry of New Jersey, Camden 08103, USA.
Larijani
G E
GE
Eger
E I
EI
D000328:Adult; D000758:Anesthesia / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D004987:Ethers / Q000009:adverse effects*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000009:adverse effects*; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects* / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D000077149:Sevoflurane; D013997:Time Factors
D018685:Anesthetics, Inhalation; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D000077149:Sevoflurane; C078742:fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether