Correlative and mechanistic QSAR models in toxicology.
An outline is provided on the development and use of correlative and mechanistic approaches to predictive toxicology, with particular emphasis on the experience at the U.S. EPA as applied to assessing the potential hazard posed by new industrial chemicals for which little or no test data are provided under the Toxic Substances Control Act. This information is presented with a historical perspective.
Lipnick
R L
RL
Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, DC 20460, USA.
D000818:Animals; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D011237:Predictive Value of Tests; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000379:methods*; D014481:United States; D014484:United States Environmental Protection Agency
D015386:Hazardous Substances