title: Atypical chronic myelogenous leukemia following immunosuppressive therapy for severe aplastic anemia.
abstract: Late clonal complications of aplastic anemia (AA) such as acute leukemia, myelodysplastic syndromes or paroxysmal nocturnal hemoglobinuria have been recognized for a long time. To our knowledge, chronic myelogenous leukemia (CML) as a late complication of severe aplastic anemia has as yet not been reported. We report here a case of AA treated successfully with antilymphocytic globulin and cyclosporin in whom Ph1 negative, BCR/ABL negative CML developed 8 years after diagnosis of AA. This case of atypical, secondary CML was refractory to treatment with interferon alpha and hydroxyurea.
authors.affiliation: Department of Hematology, Medical University of Lódź, Poland. robaktad@psk2.am.lodz.pl
authors.forename: T
authors.initials: T
authors.lastname: Robak
authors.forename: M
authors.initials: M
authors.lastname: Kasznicki
authors.forename: B
authors.initials: B
authors.lastname: Strzelecka
authors.forename: J
authors.initials: J
authors.lastname: Bartkowiak
authors.forename: M
authors.initials: M
authors.lastname: Debiec-Rychter
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000209:etiology*; D008297:Male; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents