Recurrent DNA copy number losses associated with metastasis of larynx carcinoma.
Squamous cell carcinomas of the head and neck show frequent and complex chromosome aberrations, but little is known about the changes that occur during the metastatic process. To compare the accumulation of changes in primary and metastatic tumors we analyzed 19 pairs of primary larynx cancer tumors and their metastases. The most frequent changes were found at 3p, 3q, 5p, 9, and 13. Losses at 13, 8p, and 9q were more frequent in metastases than in primary tumors.
Kujawski
M
M
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Sarlomo-Rikala
M
M
Gabriel
A
A
Szyfter
K
K
Knuutila
S
S
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000556:secondary; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D018628:Gene Dosage; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000556:secondary*
D004273:DNA, Neoplasm