title: [Response of vasopressin and tyrosine hydroxylase expressing neurons of the rat supraoptic nucleus to chronic osmotic stimulation].
abstract: This study has evaluated the dynamic of intracellular vasopressin and tyrosine hydroxylase contents in the neuron cell bodies in the supraoptic nucleus and in the axons of the posterior lobe in rats drinking 2% NaCl for 1, 2, and 3 weeks. The number of vasopressin-immunoreactive neurons increased by the end of the second week of osmotic stimulation that might be explained by the onset of vasopressin synthesis in the neurons which do not synthesize this neurohormone under normal physiological conditions. The concentration of vasopressin fell down continuously during the first two weeks of salt-loading, apparently, due to predominance of the vasopressin release over its synthesis. Over the third week of salt-loading, the intracellular concentration of vasopressin was not changed significantly suggesting the establishment of the dynamic equilibrium between the vasopressin synthesis and release. The number of tyrosine hydroxylase-immunoreactive neurons and the amount of tyrosine hydroxylase in cell bodies and the large axonal swellings, Herring bodies, increased gradually showing that the rate of tyrosine hydroxylase synthesis prevailed over that of its enzymatic degradation. Thus, the chronic stimulation of vasopressin neurons is accompanied by a number of the adaptive reactions; the most important is related to the onset of vasopressin and tyrosine hydroxylase synthesis in the neurons which do not synthetize both of them under normal conditions.
authors.affiliation: Laboratory of Hormonal Regulations, Russian Academy of Sciences, Moskow, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Abramova
authors.forename: A
authors.initials: A
authors.lastname: Calas
authors.forename: P
authors.initials: P
authors.lastname: Maiily
authors.forename: J
authors.initials: J
authors.lastname: Thibault
authors.forename: M V
authors.initials: MV
authors.lastname: Ugriumov
mesh_terms: D000818:Animals; D001369:Axons / Q000201:enzymology / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D009995:Osmosis; D010902:Pituitary Gland / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000494:pharmacology; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D014667:Vasopressins; D012965:Sodium Chloride; D014446:Tyrosine 3-Monooxygenase