[The biogenic amine content of rat tissues in the postresuscitation period following hemorrhagic shock and the effect of the preparation semax].
LPO products were measured in plasma and biogenic amines (serotonin, adrenalin, noradrenalin) in tissues of rats in different periods after hemorrhagic shock provoked by taking blood and maintenance of arterial pressure at the level of 40 mm Hg for 1 hour. Resuscitation was conducted by administration of autoblood. It was found that splenic serotonin levels decreased on experiment day 7 and went up on day 28. On late experiment stages noradrenalin levels in the adrenals were high. Early after resuscitation the trend was noted to higher LPO products concentration in plasma and serotonin in the brain stem. Intravenous injection of semax prevented serotonin fall in the spleen on experiment day 7. It is suggested that biogenic amines, especially serotonin system, are involved in mechanisms of postresuscitation disorders, in cerebral defects in particular, through prolongation of secondary hypoxia early after hemorrhagic shock and activation of hypothalamo-hypophyso-adrenal system late after the shock.
Bastrikova
N A
NA
Shestakova
S V
SV
Antonova
S V
SV
Krushinskaia
Ia V
IaV
Goncharenko
E N
EN
Kudriashova
N Iu
NIu
Novoderzhkina
I S
IS
Sokolova
N A
NA
Kozhura
V L
VL
D000311:Adrenal Glands / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D001933:Brain Stem / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D012151:Resuscitation / Q000379:methods; D012771:Shock, Hemorrhagic / Q000378:metabolism* / Q000628:therapy; D013154:Spleen / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D001679:Biogenic Amines; D008055:Lipids; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone