Long-term deprivation of oestrogens by ovariectomy potentiates beta-amyloid-induced working memory deficits in rats.
1 In the present study, we examined whether deprivation of oestrogens by ovariectomy could modify learning and memory deficits caused by a continuous intracerebroventricular (i.c.v.) infusion of amyloid beta-peptide (Abeta), the major constituent of senile plaques in AD. 2 Neither long-term (3 months) nor short-term (1 month), deprivation of oestrogens by ovariectomy caused a significant impairment in spatial learning and memory in a water maze and spontaneous alternation behaviour in a Y-maze. 3 A continuous i.c.v. infusion of Abeta-(1-42) caused spatial learning and memory deficits in both ovariectomized and sham-operated rats. 4 The Abeta-induced working memory deficits were significantly potentiated in ovariectomized rats compared with sham-operated rats when mnemonic ability was examined 3 months after ovariectomy. 5 These results suggest that long-term deprivation of oestrogens induced by ovariectomy increases susceptibility to memory deficits produced by Abeta-(1-42) in rats.
Yamada
K
K
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Showa-ku, Nagoya 466-8560, Japan.
Tanaka
T
T
Zou
L B
LB
Senzaki
K
K
Yano
K
K
Osada
T
T
Ana
O
O
Ren
X
X
Kameyama
T
T
Nabeshima
T
T
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007276:Injections, Intraventricular; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D010052:Ovariectomy; D010446:Peptide Fragments / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D016229:Amyloid beta-Peptides; D004967:Estrogens; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D004958:Estradiol; D005640:Follicle Stimulating Hormone