title: Cost of bacterial vaginosis in pregnancy. Decision analysis and cost evaluation of a clinical study in Germany.
abstract: OBJECTIVE
  To estimate the economic impact of screening for and treatment of bacterial vaginosis during early pregnancy.
  
  
  METHODS
  Data from a clinical study that aligned two screening and treatment strategies and a no-screening or treatment strategy with three gynecologic practices in Berlin were used in decision tree analysis. Costs applied to the clinical outcomes were determined from standard German references and the charges from university clinics.
  
  
  RESULTS
  Practices A and B screened all 600 patients in the early second trimester and treated the positive cases with clindamycin 2% vaginal cream (A) or a Lactobacillus preparation (B), which incurred lower total costs, $493,159 and $497,619, as compared to practice C (total costs, $534,926), which did not screen or treat for bacterial vaginosis. Including costs of screening and treatment, the net savings of practice A as compared to practice C was estimated to be $47,316.
  
  
  CONCLUSIONS
  The presence of more preterm, premature and low-birth-weight infants added costs for practice C. The estimated cost savings lend support to the value of screening and treatment for bacterial vaginosis in early pregnancy.
authors.affiliation: Thomas D. Szucs Medical Economics Research Group, Munich, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Müller
authors.forename: K
authors.initials: K
authors.lastname: Berger
authors.forename: N
authors.initials: N
authors.lastname: Dennemark
authors.forename: M
authors.initials: M
authors.lastname: Oleen-Burkey
mesh_terms: D000282:Administration, Intravaginal; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D003365:Costs and Cost Analysis; D005260:Female; D005858:Germany; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007778:Lactobacillus; D007752:Obstetric Labor, Premature / Q000209:etiology / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000191:economics* / Q000628:therapy; D016585:Vaginosis, Bacterial / Q000150:complications / Q000191:economics* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin