title: Effects of soft drink and table beer consumption on insulin response in normal teenagers and carbohydrate drink in youngsters.
abstract: There is ample evidence that breast cancer susceptibility is induced during the developmental stages of the human breast where, in a manner related to sex-steroid hormones, insulin plays an important role. In turn, nutrition might be implicated. Regular soft drinks and table beer, both carbohydrate-containing drinks, are candidates affecting insulin concentrations. Eleven teenagers, between the ages of 13 and 17 years, consumed a soft drink and a table beer in a crossover study. The blood levels of insulin and glucose were related to anthropomorphometric and endocrine factors. In contrast to table beer, consumption of regular soft drinks induced a fast and dramatic increase in both glucose and insulin concentration within a maximum 1 hour after consumption. The insulin response was linearly correlated to the body mass index (BMI). Children with a small increase in BMI are highly sensitive to regular soft drinks with regard to glucose and insulin response. The finding suggests a vicious circle of high caloric drinks, increase in BMI and insulin response. It is one of the nutritional pathways which might affect susceptibility for breast cancer in youngsters. Table beer, a drink with fermented sugars, does not share these effects on carbohydrate metabolism.
authors.affiliation: European Cancer Prevention Organization, Gebouw C, Diepenbeek, Belgium. janssens.ECP@skynet.be
authors.forename: J P
authors.initials: JP
authors.lastname: Janssens
authors.forename: N
authors.initials: N
authors.lastname: Shapira
authors.forename: P
authors.initials: P
authors.lastname: Debeuf
authors.forename: L
authors.initials: L
authors.lastname: Michiels
authors.forename: R
authors.initials: R
authors.lastname: Putman
authors.forename: L
authors.initials: L
authors.lastname: Bruckers
authors.forename: D
authors.initials: D
authors.lastname: Renard
authors.forename: G
authors.initials: G
authors.lastname: Molenberghs
mesh_terms: D000293:Adolescent; D001515:Beer; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000209:etiology; D002253:Carbonated Beverages; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin