title: Analysis of the clinical benefit of 5-fluorouracil and radiation treatment in locally advanced pancreatic cancer.
abstract: OBJECTIVE
  To assess the palliative benefit of 5-fluorouracil (5-FU) and radiotherapy in patients with surgically unresectable localized pancreatic cancer.
  
  
  METHODS
  Twenty-five patients with locally advanced surgically unresectable symptomatic pancreatic cancer received 5-FU chemotherapy and local radiation therapy. They were retrospectively reviewed in regard to their clinical benefit response (a composite of measurement of pain assessment, weight, and Karnofsky performance status [KPS]), as well as radiological response, time to progression, and overall survival.
  
  
  RESULTS
  Median survival for the 25 patients was 9 months and median progression-free survival was 6 months. Thirty-two percent of patients survived in excess of 1 year. Analgesic requirements increased >50% in 2 patients and KPS deteriorated in 10 patients. Of the 13 remaining patients, 2 sustained a >7% weight loss and 2 gained weight post-treatment. Six patients improved in one parameter of analgesic consumption, weight loss or KPS without deteriorating in any others. Thus, the clinical benefit response index for 5-FU-radiation was 6/25 (24%). In terms of tumor response, 8 patients (44%) demonstrated a reduction in tumor volume post-treatment, 4 of whom (22%) experienced a >50% reduction. Four additional patients had radiologically stable disease.
  
  
  CONCLUSIONS
  In this retrospective analysis, the clinical benefit response index for 5-FU-radiation was 24%, a value similar to the 23.8% reported for single agent gemcitabine. The median survival of 7 months was also similar to the 5.65 months reported for gemcitabine. The radiological partial response rate of 22% and the 1-year survival of 32% were higher for 5-FU-radiation than the reported values for gemcitabine. A randomized trial would be necessary to compare 5-FU-radiation to gemcitabine directly; however, from this review it did not appear that the overall palliative benefit of 5-FU-radiation was inferior to gemcitabine.
authors.affiliation: Department of Radiation Oncology, London Regional Cancer Centre and University of Western Ontario, Canada.
authors.forename: B J
authors.initials: BJ
authors.lastname: Fisher
authors.forename: F E
authors.initials: FE
authors.lastname: Perera
authors.forename: W
authors.initials: W
authors.lastname: Kocha
authors.forename: A
authors.initials: A
authors.lastname: Tomiak
authors.forename: M
authors.initials: M
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Vincent
authors.forename: G S
authors.initials: GS
authors.lastname: Bauman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies
chemical_list: D000700:Analgesics; D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil