title: Effect of selective versus nonselective beta blockade on QT dispersion in patients with nonischemic dilated cardiomyopathy.
abstract: We retrospectively examined the electrocardiograms in all of our patients with nonischemic dilated cardiomyopathy and normal sinus rhythm before and after at least 3 months of metoprolol (n = 12), bucindolol (n = 8), carvedilol (n = 6), or no beta blocker (n = 9). Both beta1-selective and nonselective beta-adrenergic blockade reduced QTc dispersion equally in patients with dilated cardiomyopathy.
authors.affiliation: Department of Internal Medicine, The University of Texas Southwestern Medical Centers, Dallas 75216, USA.
authors.forename: S I
authors.initials: SI
authors.lastname: Fesmire
authors.forename: L G
authors.initials: LG
authors.lastname: Marcoux
authors.forename: D S
authors.initials: DS
authors.lastname: Lyyski
authors.forename: M K
authors.initials: MK
authors.lastname: Sprague
authors.forename: H L
authors.initials: HL
authors.lastname: Kennedy
authors.forename: E J
authors.initials: EJ
authors.lastname: Eichhorn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D002227:Carbazoles / Q000494:pharmacology; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D000077261:Carvedilol; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D008875:Middle Aged; D011412:Propanolamines / Q000494:pharmacology; D012189:Retrospective Studies; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; C024307:bucindolol; D008790:Metoprolol