Adenovirus vectors for gene delivery.
Recent endeavors in the development of adenovirus as a gene vector have focused on the modification of virus tropism, the accommodation of larger genes, and the increase in stability and control of transgene expression. Whereas partial or total deletions of viral genes increase the cloning capacity and partly reduce the cellular immune response, control of the humoral response, which often precludes efficient readministration, remains a challenge.
Benihoud
K
K
Laboratoire de Vectorologie et Transfert de Gènes UMR1582 CNRS/Rhône-Poulenc Gencell/IGR Institut Gustave Roussy 94805, Villejuif, France. benihoud@igr.fr
Yeh
P
P
Perricaudet
M
M
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D007107:Immune System / Q000821:virology; D019076:Transgenes