title: Guaianolides from Centaurea nicolai: antifungal activity.
abstract: A new guaianolide, 3-deacetyl-9-O-acetylsalograviolide A, along with four known closely related lactones, salograviolide A, 9-O-acetylsalograviolide A, kandavanolide and salograviolide B were detected in the aerial parts of the flowering plant Centaurea nicolai. Antifungal tests performed on salograviolide A and its 9-O-acetyl and 3-O-deacetyl-9-O-acetyl derivatives revealed inhibitory activity against Aspergillus niger, A. ochraceus, Penicillium ochrochloron, Cladosporium cladosporoides, Fusarium tricinctum and Phomopsis helianthi. Neither of them was active against Trichoderma viride.
authors.affiliation: Institute for Chemistry, Technology and Metallurgy, Belgrade, Minor Yugoslavia.
authors.forename: V
authors.initials: V
authors.lastname: Vajs
authors.forename: N
authors.initials: N
authors.lastname: Todorović
authors.forename: M
authors.initials: M
authors.lastname: Ristić
authors.forename: V
authors.initials: V
authors.lastname: Tesević
authors.forename: B
authors.initials: B
authors.lastname: Todorović
authors.forename: P
authors.initials: P
authors.lastname: Janaćković
authors.forename: P
authors.initials: P
authors.lastname: Marin
authors.forename: S
authors.initials: S
authors.lastname: Milosavljević
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes