Effects of short-course buserelin therapy on adenomyosis. A report of two cases.
BACKGROUND
Hysterectomy and hysteroscopic endometrial ablation remain common treatment of symptomatic adenomyosis for women who have completed childbearing. However, for patients who wish to avoid surgery and in whom adenomyosis is suspected of causing infertility, repeated abortion or physical symptoms, medical treatment with gonadotropin-releasing hormone analogue (GnRH-a) should be considered.


METHODS
Two cases of documented adenomyosis were suspected of causing infertility; both were treated with a three-month course of GnRH-a via a nasal spray. Both patients experienced relief of symptoms and conceived within six months of the cessation of treatment.


CONCLUSIONS
The efficacy and safety of a short course of GnRH-a treatment of adenomyosis may be considered in patients who take less time than others to achieve a significant reduction of uterine size and relief of symptoms and in those who develop side effects.
Huang
F J
FJ
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taiwan.
Kung
F T
FT
Chang
S Y
SY
Hsu
T Y
TY
D000281:Administration, Intranasal; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000627:therapeutic use; D002064:Buserelin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D011247:Pregnancy; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D002064:Buserelin