[The efficacy of using low doses of immunomodulators for treating experimental tumors].
The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.
Shalimov
S A
SA
Potebnia
G P
GP
Lisovenko
G S
GS
Litvinenko
A A
AA
Keĭsevich
L V
LV
Reshetniak
T A
TA
Volchenskova
I I
II
Maĭdanevich
N N
NN
Semernikov
V A
VA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage*; D019496:Cancer Vaccines / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage*; D018736:DNA Adducts / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D013997:Time Factors; D015008:Yersinia enterocolitica
D000276:Adjuvants, Immunologic; D001685:Biological Factors; D019496:Cancer Vaccines; D018736:DNA Adducts; C057270:cisplatin-DNA adduct; C096287:erbisol; D002945:Cisplatin