Extragonadal teratocarcinoma in chimeric mice.
Chimeric mice often are created through the genetic manipulation of the mouse embryo in the process of developing animal models of disease. These mice have variable percentages of their somatic and germ cells derived from the donor embryonic stem cells and host blastocysts. In the development of mouse models deficient in the breast cancer susceptibility gene 2 (Brca2) or the 70-kd heat shock protein (Hsp70-2), 3-4-week-old chimeras developed single or multiple masses composed of both well-differentiated and poorly differentiated tissues derived from all three germ layers. These cases of extragonadal teratocarcinoma, a rarely reported tumor, may be related to the genetic predisposition of the 129/Ola mouse strain used to generate the embryonic stem cells.
Blackshear
P
P
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Mahler
J
J
Bennett
L M
LM
McAllister
K A
KA
Forsythe
D
D
Davis
B J
BJ
D000818:Animals; D024682:BRCA2 Protein; D002678:Chimera; D004195:Disease Models, Animal; D005834:Genital Neoplasms, Male / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000235:genetics; D012376:Rodent Diseases / Q000235:genetics / Q000473:pathology*; D018243:Teratocarcinoma / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D013737:Testis / Q000473:pathology; D014157:Transcription Factors / Q000235:genetics
D024682:BRCA2 Protein; D018840:HSP70 Heat-Shock Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors