[Heterotropic heart transplantation in young patients with elevated pulmonary vascular resistance].
Right heart failure due to elevated PVR is one of the major causes of mortality and morbidity after orthotopic heart transplantation. In 5 patients (median age 14 years) with dilated or restrictive cardiomyopathy and important elevation of the PVR, a heterotopic heart transplantation was performed using the technique reported by Yacoub (the donor pulmonary artery was implanted on the recipient right atrium). All the patients presented with at least two of the following parameters: PVR/m2 > 6 U, transpulmonary gradient > 15 mmHg, mean pulmonary pressure > 50 mmHg. One patient with restrictive cardiomyopathy died three months after transplantation of severe failure of the native right ventricle. The other four patients, with a mean follow-up of 29 months, are in good clinical and hemodynamic condition and later post-operative catheterizations showed a progressive reduction of the pulmonary pressure.


CONCLUSIONS
Our experience suggests that this type of heterotopic heart transplantation can be performed successfully in patients with secondary pulmonary hypertension. Particular attention should be paid to patients with restrictive cardiomyopathy and important right ventricle dysfunction, in which a complete heterotopic heart transplantation could be a better solution.
Gamba
A
A
Unità Operativa di Cardiochirugia Azienda Ospedaliera Ospedali Riuniti di Bergamo.
Fiocchi
R
R
Mamprin
F
F
Senni
M
M
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002311:Cardiomyopathy, Dilated / Q000601:surgery; D002313:Cardiomyopathy, Restrictive / Q000601:surgery; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D014655:Vascular Resistance / Q000502:physiology