[Use of antioxidant defense of tissues in free microsurgical transplant of complex-composite flaps].
In experiment on 25 epigastric muscular flaps of rabbits the possibilities of the flap tissues damage prophylaxis in the ischemia period were studied up as well as their defense from peroxidal and the free-radicals oxidation of the membrane phospholipids in the reperfusion period. There were noted suppression of the lipid's peroxidation processes, the raise of the flap's tissues antioxidant defense, the cellular and subcellular membranes stabilization with preservation of the vessels endothelium integrity after preliminary intraarterial infusion of the lipin, unithiol, ascorbic acid and isoptin mixture into the flap. The data obtained witness the perspective of the studied preparations application during microsurgical transplantation of composite complexes of tissues.
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D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D002462:Cell Membrane / Q000378:metabolism; D002614:Chelating Agents / Q000008:administration & dosage; D004730:Endothelium, Vascular / Q000378:metabolism; D005609:Free Radicals; D007261:Infusions, Intra-Arterial; D015227:Lipid Peroxidation; D009930:Organic Chemicals; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D013524:Surgical Flaps; D014494:Unithiol / Q000008:administration & dosage; D014665:Vasodilator Agents / Q000008:administration & dosage; D014700:Verapamil / Q000008:administration & dosage
D000890:Anti-Infective Agents; D000975:Antioxidants; D002614:Chelating Agents; D005609:Free Radicals; D009930:Organic Chemicals; D010743:Phospholipids; D014665:Vasodilator Agents; C088310:lipine; D014494:Unithiol; D014700:Verapamil; D001205:Ascorbic Acid