Human bronchial artery blood flow after lung Tx with direct bronchial artery revascularization.
The inaccuracy of measuring human bronchial artery blood flow has previously been considerable. En bloc double-lung transplantation with bronchial artery revascularization (BAR) using a single conduit offers the unique opportunity of direct measurement of the total bronchial artery blood flow. In eight en bloc double-lung-transplanted patients with complete BAR, the basal blood flow was measured by using a 0.014-in. Doppler guide wire and arteriography. The average peak velocity in the conduit was 12-73 cm/s [+/-2.1 (SD) cm/s], and the conduit diameter was 1.7-3.1 mm [+/-0.10 (SD) mm], giving individual basal flow values between 19 and 67 ml/min [+/-5 (SD) ml/min], or 0.2-1.9% of estimated cardiac output. In three patients basal measurements were followed by injection of nitroglycerin and verapamil into the conduit. This increased the bronchial artery flow to 121-262% of basal values (31-89 ml/min). The measured values appear more physiologically plausible than previous bronchial artery blood flow measurements in humans.
Nørgaard
M A
MA
Department of Cardiothoracic Surgery, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark. bar@rh.dk
Hove
J D
JD
Efsen
F
F
Saunamäki
K
K
Hesse
B
B
Pettersson
G
G
D000792:Angiography; D001981:Bronchial Arteries / Q000187:drug effects / Q000502:physiology* / Q000601:surgery*; D002302:Cardiac Output / Q000502:physiology; D006801:Humans; D017078:Laser-Doppler Flowmetry; D016040:Lung Transplantation / Q000502:physiology*; D005996:Nitroglycerin / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014656:Vascular Surgical Procedures; D014664:Vasodilation / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D014665:Vasodilator Agents; D014700:Verapamil; D005996:Nitroglycerin