title: The clinical status of cadaveric renal transplant patients treated for 10 year with cyclosporine therapy.
abstract: In this paper we assessed the clinical status of 150 cadaveric renal transplant patients who received cyclosporine without interruption for 10 yr. The mean creatinine clearance was 59.2 +/- 15.71 at 1 yr and 55.6 +/- 24.91 mL/min at 10 yr (p = 0.039). Patients were subdivided into four quartiles according to the mean creatinine clearance at 1 yr. The 14 patients with the lowest quartile showed a significant decrease of creatinine clearance from the 1st to 10th year (from 31.5 +/- 5.83 to 24.8 +/- 14.00 mL/min; p = 0.038) while no difference between the mean creatinine clearance at 1 and at 10 yr was found in the other three quartiles. At 10 yr, 84.6% patients needed antihypertensive therapy, a rate similar to that seen at 1 yr (81.4%). The mean plasma cholesterol (253 +/- 57.8 mg/dL) and triglyceride (197 +/- 113.1 mg/dL) at 10 yr were similar to those found at +/- yr (243 +/- 48.2 and 201 +/- 143.0 mg/dL, respectively). Most patients have a high degree of rehabilitation 10 yr after uninterrupted cyclosporine therapy and all patients but 3 were able to work.
authors.affiliation: Divisione di Nefrologia e Dialisi, IRCCS, Ospedale Maggiore, Milan, Italy. croff1@polic.cilea.it
authors.forename: C
authors.initials: C
authors.lastname: Ponticelli
authors.forename: A
authors.initials: A
authors.lastname: Aroldi
authors.forename: A
authors.initials: A
authors.lastname: Elli
authors.forename: G
authors.initials: G
authors.lastname: Montagnino
authors.forename: A
authors.initials: A
authors.lastname: Vegeto
authors.forename: A
authors.initials: A
authors.lastname: Tarantino
mesh_terms: D000328:Adult; D002102:Cadaver; D003404:Creatinine / Q000378:metabolism; D016572:Cyclosporine / Q000627:therapeutic use*; D003920:Diabetes Mellitus; D004651:Employment; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000009:adverse effects; D008055:Lipids / Q000097:blood; D008297:Male; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D007166:Immunosuppressive Agents; D008055:Lipids; D016572:Cyclosporine; D003404:Creatinine