title: Effects of vitamin E on ozone-induced memory deficits and lipid peroxidation in rats.
abstract: Ozone exposure induces increased production of free radicals which may result in oxidative stress. The objectives of this study were to determine the antioxidant effects of vitamin E on memory deficits and lipid peroxidation due to oxidative stress caused by acute ozone exposure. Rats were exposed to 0.7 p.p.m. ozone for 4 h and 50 mg/kg vitamin E was administered either before or after exposure. Experiment 1 evaluated alterations in short-term and long-term memory in a passive avoidance task. Experiment 2 quantified lipid peroxidation levels of the striatum, hippocampus and frontal cortex. Vitamin E administered before or after ozone exposure blocked memory deterioration and increases in lipid peroxidation levels associated with oxidative stress.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, DF.
authors.forename: A L
authors.initials: AL
authors.lastname: Guerrero
authors.forename: C
authors.initials: C
authors.lastname: Dorado-Martínez
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez
authors.forename: K
authors.initials: K
authors.lastname: Pedroza-Ríos
authors.forename: G
authors.initials: G
authors.lastname: Borgonio-Pérez
authors.forename: S
authors.initials: S
authors.lastname: Rivas-Arancibia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000523:psychology*; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D010083:Oxidants, Photochemical; D018384:Oxidative Stress; D010126:Ozone; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010083:Oxidants, Photochemical; D014810:Vitamin E; D010126:Ozone