title: Metabolic activation of the subependymal zone after cortical injury.
abstract: The subependymal zone (SEZ) of the adult mammalian forebrain contains a population of progenitor cells that proliferate in response to brain injury. This study examined the effect of cortical injury on metabolic activity in the SEZ using quantitative histochemistry of cytochrome oxidase. The SEZ showed significantly enhanced cytochrome oxidase activity in rats with electrolytic cortical injuries relative to sham-operated controls, while other brain regions showed no such changes. The results indicate that the SEZ had increased oxidative energy demands, and thus provide metabolic evidence that SEZ cells are activated in response to brain injury.
authors.affiliation: Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 78712, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Valla
authors.forename: J L
authors.initials: JL
authors.lastname: Humm
authors.forename: T
authors.initials: T
authors.lastname: Schallert
authors.forename: F
authors.initials: F
authors.lastname: Gonzalez-Lima
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D002540:Cerebral Cortex / Q000293:injuries*; D003576:Electron Transport Complex IV / Q000378:metabolism; D004789:Enzyme Activation; D004805:Ependyma / Q000201:enzymology / Q000378:metabolism*; D006651:Histocytochemistry; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D012016:Reference Values
chemical_list: D003576:Electron Transport Complex IV