A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Brown
P J
PJ
Department of Medicinal Chemistry, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, USA. pjb5890@glaxowellcome.com
Winegar
D A
DA
Plunket
K D
KD
Moore
L B
LB
Lewis
M C
MC
Wilson
J G
JG
Sundseth
S S
SS
Koble
C S
CS
Wu
Z
Z
Chapman
J M
JM
Lehmann
J M
JM
Kliewer
S A
SA
Willson
T M
TM
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000819:agonists*; D011345:Fenofibrate / Q000494:pharmacology; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000819:agonists*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*; D016335:Zinc Fingers
D002087:Butyrates; D004268:DNA-Binding Proteins; D000960:Hypolipidemic Agents; D009687:Nuclear Proteins; D010671:Phenylurea Compounds; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C121804:GW 9578; D011345:Fenofibrate