title: Control of cell migration during Caenorhabditis elegans development.
abstract: In Caenorhabditis elegans, cell migration is guided by localized cues, including molecules such as EGL-17/FGF and UNC-6/netrin. These external cues are linked to an intracellular response to migrate, at least in part, by CED-5, a homolog of DOCK180/MBC, and MIG-2, a Rac-like GTPase. In addition, metalloproteases are required for a cell migration that controls organ shape.
authors.affiliation: Program in Cell and Molecular Biology 433 Babcock Drive University of Wisconsin-Madison Madison, WI 53706, USA.
authors.forename: R
authors.initials: R
authors.lastname: Blelloch
authors.forename: C
authors.initials: C
authors.lastname: Newman
authors.forename: J
authors.initials: J
authors.lastname: Kimble
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000235:genetics / Q000254:growth & development; D029742:Caenorhabditis elegans Proteins; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth; D005801:Genes, Homeobox; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D007814:Larva; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D008666:Metalloendopeptidases / Q000235:genetics / Q000502:physiology; D009024:Morphogenesis; D009419:Nerve Tissue Proteins; D000075385:Netrins; D011518:Proto-Oncogene Proteins / Q000502:physiology; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D029742:Caenorhabditis elegans Proteins; D015815:Cell Adhesion Molecules; C112493:EGL-15 protein, C elegans; C105157:Egl-17 protein, C elegans; D006133:Growth Substances; D015801:Helminth Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; C120452:MIG-13 protein, Caenorhabditis elegans; C081538:Mab-5 protein, C elegans; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000075385:Netrins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D017978:Receptors, Growth Factor; D014157:Transcription Factors; C102174:UNC-40 protein, C elegans; C078146:UNC-6 protein, C elegans; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C077588:UNC-5 protein, C elegans; C119674:GON-1 protein, C elegans; D008666:Metalloendopeptidases