Differentiation in a rat PC12 cell line induced by ostruthin and (-)-bornyl ferulate, constituents of a Chinese herbal medicine.
A search for neuritogenic compounds in Chinese herbs resulted in the isolation of two known substances, ostruthin and (-)-bornyl ferulate, from Notopterygium incisum (and/or N. forbesii). Both compounds induced comparable neurite-like structures in 20% of rat PC12 cells at 2 micrograms/ml, and showed cytotoxicity at concentrations higher than 3 micrograms/ml.
Qi
J
J
Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
Ojika
M
M
Sakagami
Y
Y
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003373:Coumaric Acids / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D014468:Umbelliferones / Q000494:pharmacology*
D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D014468:Umbelliferones; C115951:bornyl ferulate; C008719:ostruthin