title: [Short interval change of 99mTc-ethyl cysteinate dimer single photon emission computed tomography in Wilson's disease].
abstract: We studied short interval change of cranial computed tomography (CT), magnetic resonance imaging (MRI) and 99mTc-ethyl cysteinate dimer single photon emission computed tomography (99mTc-ECD SPECT) in a case of Wilson's disease. Before treatment, CT scan showed low density changes in the bilateral thalamus and basal ganglia, and MRI demonstrated high intensity in same lesions. 99mTc-ECD SPECT study revealed a hypoperfusion in bilateral thalamus. After 2 months under D-penicillamine therapy, neurological findings had improvement. Hypoperfusion in the thalamus with 99mTc-ECD SPECT significantly improved, whereas abnormal findings of CT scan and MRI persisted. 99mTc-ECD SPECT study may be useful for the planning of the treatment of Wilson's disease.
authors.affiliation: Department of Neurology, Shimizu Municipal Hospital, Shizuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Imai
authors.forename: H
authors.initials: H
authors.lastname: Nozaki
authors.forename: K
authors.initials: K
authors.lastname: Miyata
authors.forename: Y
authors.initials: Y
authors.lastname: Terayama
authors.forename: N
authors.initials: N
authors.lastname: Ishihara
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D015609:Organotechnetium Compounds; D010396:Penicillamine / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D013788:Thalamus / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D010396:Penicillamine; C059659:technetium Tc 99m bicisate; D003545:Cysteine