CYP1A1.
CYP1A1 plays an important role in the metabolism of polycyclic hydrocarbons that occur in the environment and several studies suggest that the genetic polymorphism of the gene may play a role in the predisposition to cancer. In order to evaluate the function of CYP1A1 in vivo as a host factor determinant of environmentally-caused cancers in humans, additional investigations are needed involving not only molecular epidemiological approaches in different ethnic populations but also more direct approaches such as the use of gene-targeted mice as a model system.
Kawajiri
K
K
Department of Biochemistry, Saitama Cancer Center Research Institute, Ina, Japan.
D000818:Animals; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000502:physiology*; D004781:Environmental Exposure; D020022:Genetic Predisposition to Disease / Q000145:classification / Q000235:genetics*; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D051379:Mice; D017720:Molecular Epidemiology; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000235:genetics*; D010641:Phenotype; D011083:Polycyclic Compounds / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics*
D011083:Polycyclic Compounds; D019363:Cytochrome P-450 CYP1A1