Prognosis in adult AML is precisely predicted by the DISC-assay using the chemosensitivity-index Ci.
We prospectively investigated the correlation between DISC-assay results and clinical response and also survival in patients with AML using a new method of evaluation.
Staib
P
P
Clinic I for Internal Medicine, University of Cologne, Germany.
Lathan
B
B
Schinköthe
T
T
Wiedenmann
S
S
Pantke
B
B
Dimski
T
T
Voliotis
D
D
Diehl
V
V
D000328:Adult; D000616:Aminoglutethimide / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000633:toxicity*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001752:Blast Crisis; D002470:Cell Survival / Q000187:drug effects; D003561:Cytarabine / Q000008:administration & dosage; D003613:Danazol / Q000008:administration & dosage; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D012074:Remission Induction; D016019:Survival Analysis; D013629:Tamoxifen / Q000008:administration & dosage; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D003561:Cytarabine; D013629:Tamoxifen; D000616:Aminoglutethimide; D016179:Granulocyte Colony-Stimulating Factor; D014740:Vidarabine; D003613:Danazol; D015255:Idarubicin