Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees.
A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1beta (MIP-1beta) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1beta. Levels of MIP-1beta and MCP-1 release were differentially regulated during endotoxemia.
Dekkers
P E
PE
Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. P.E.Dekkers@AMC.UVA.NL
Levi
M
M
van Deventer
S J
SJ
van der Poll
T
T
D000818:Animals; D018932:Chemokine CCL2 / Q000378:metabolism*; D054407:Chemokine CCL4; D019446:Endotoxemia / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity*; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism*; D010215:Papio; D010972:Platelet Activating Factor / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D018932:Chemokine CCL2; D054407:Chemokine CCL4; D004731:Endotoxins; D019402:Macrophage Inflammatory Proteins; D010972:Platelet Activating Factor; D014409:Tumor Necrosis Factor-alpha