[Toxicologic findings in suicide with doxepin and paroxetine].
A young nurse was found dead in her flat. In chemical-toxicological analysis the following femoral blood drug concentrations were determined: paroxetine 0.176 mg/l, doxepine 82.12 mg/l, desmethyldoxepine 0.34 mg/l. Additionally the drug concentrations were determined in various body fluids and organs. The results of the described fatality are discussed. For interpretation of toxicologic results in antidepressant fatalities ratios of parent drug to metabolite and postmortem drug redistribution should be taken into account.
Musshoff
F
F
Institut für Rechtsmedizin, Universität Bonn.
Grellner
W
W
Madea
B
B
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000493:pharmacokinetics / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000493:pharmacokinetics / Q000506:poisoning*; D004316:Doxepin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000493:pharmacokinetics / Q000506:poisoning*; D013405:Suicide / Q000331:legislation & jurisprudence*; D014018:Tissue Distribution
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D004316:Doxepin; D017374:Paroxetine; C028701:desmethyldoxepin