Endothelial adhesion molecules in the development of the vascular tree: the garden of forking paths.
In the past, year targeted null mutation studies have further supported the concept that endothelial cell-matrix and cell-cell adhesion is involved in the formation and maintenance of the network of branched tubes within the vascular tree. In addition, recent results derived from the closely related experimental system of branching tubulogenesis in epithelial cells may provide an appealing model for endothelial biology.
Bazzoni
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G
Laboratory of Vascular Biology Istituto di Ricerche Farmacologiche Mario Negri via Eritrea 62, 20157, Milano, Italy.
Dejana
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Lampugnani
M G
MG
D000818:Animals; D015820:Cadherins / Q000502:physiology; D002135:Calcium-Binding Proteins; D002448:Cell Adhesion; D003598:Cytoskeletal Proteins / Q000502:physiology; D051180:Desmoplakins; D019281:Dimerization; D004730:Endothelium, Vascular / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D018390:Gene Targeting; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000502:physiology*; D009154:Mutation; D018919:Neovascularization, Physiologic; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin
C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D015820:Cadherins; D002135:Calcium-Binding Proteins; C495272:Ctnna1 protein, mouse; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; D018398:Homeodomain Proteins; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010743:Phospholipids; D051880:Receptors, Notch; D000072099:Serrate-Jagged Proteins; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin