title: Cerebral microembolism diagnosed by transcranial Doppler during total knee arthroplasty: correlation with transesophageal echocardiography.
abstract: BACKGROUND
  Tourniquet deflation following total knee arthroplasty (TKA) frequently results in release of emboli into the pulmonary circulation. Small emboli may gain access to the systemic circulation via a transpulmonary route or through a patent foramen ovale. This study examined the incidence of cerebral microembolism after tourniquet release by transcranial Doppler (TCD) ultrasonography and its correlation with echogenic material detected in the left atrium.
  
  
  METHODS
  Twenty-two adult patients (9 men, 13 women) undergoing TKA were studied with simultaneous TCD ultrasonography and transesophageal echocardiography. Data were recorded after anesthesia induction and tourniquet inflation and during tourniquet deflation. Emboli counts were performed manually off-line. Echogenic material in the left atrium was qualitatively assessed and correlated with TCD data. Patients were examined postoperatively for focal neurologic deficits.
  
  
  RESULTS
  Fifteen patients had unilateral TKA (six left, nine right) and seven had bilateral TKA. Cerebral emboli were detected in 9 of 15 patients (60%) with unilateral TKA and in 4 of 7 patients (57%) with bilateral TKA. Echogenic material was identified in the left atrium in eight patients (two through a patent foramen ovale and six from the pulmonary veins). Emboli counts were significantly higher in patients with bilateral TKA compared with those with unilateral TKA (P<0.05). Duration of tourniquet time in patients with emboli was longer only during bilateral TKA (P<0.05). All patients with echogenic material in the left atrium detected by transesophageal echocardiography had emboli as assessed by TCD ultrasonography. No focal neurologic deficits were identified.
  
  
  CONCLUSIONS
  Cerebral microembolism occurs frequently during tourniquet release, even in the absence of a patient foramen ovale. This passage most likely occurs through the pulmonary capillaries or the opening of recruitable pulmonary vessels.
authors.affiliation: Department of Anesthesiology, University of Florida College of Medicine, Gainesville 32610-0254, USA. sulek@anest2.anest.ufl.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Sulek
authors.forename: L K
authors.initials: LK
authors.lastname: Davies
authors.forename: F K
authors.initials: FK
authors.lastname: Enneking
authors.forename: P A
authors.initials: PA
authors.lastname: Gearen
authors.forename: E B
authors.initials: EB
authors.lastname: Lobato
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014111:Tourniquets; D017585:Ultrasonography, Doppler, Transcranial