Risk of dementia in parents of probands with and without the apolipoprotein E4 allele. The EVA study.
OBJECTIVE
Age, family history of dementia and the epsilon 4 allele of the apolipoprotein E gene have been associated with Alzheimer's disease (AD). Considering the strength of APOE-epsilon 4 as a genetic risk factor for AD, this factor might explain a large part of the association between AD and a family history of dementia. Therefore, in the general population, a higher frequency of dementia should be observed among parents of probands with at least one epsilon 4 allele than in parents of probands without this allele.


METHODS
The study investigated a sample of 1153 volunteers between 59 and 71 years old, genotyped for the APOE gene, all participating in the EVA study. Dementia in their parents was determined using a self reported questionnaire.


RESULTS
The frequency of dementia in 2164 parents was examined and it was found that 245 were demented. The percentage of demented parents was 13.0% in the subgroup of parents of subjects having one or two epsilon 4 alleles and 10.8% in the other subgroup. The relative risk of dementia among parents according to the APOE-epsilon 4 status of probands, was calculated using a Cox model adjusted for the educational level of parents and their history of stroke: RR = 1.21 (95% CI 0.90, 1.63).


CONCLUSIONS
This lack of association supports the observation that in the general population, APOE-epsilon 4 cannot explain a large part of family history of dementia.
Danet
S
S
INSERM U360, Paris, France.
Brousseau
T
T
Richard
F
F
Amouyel
P
P
Berr
C
C
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000235:genetics*; D004522:Educational Status; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D007361:Intelligence Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010290:Parents; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E