MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy.
The authors used serial gradient-echo MRIs to detect new small hemorrhages in patients with previous lobar hemorrhage. Of 24 lobar hemorrhage patients (17 diagnosed with probable and 7 with possible amyloid angiopathy) who prospectively underwent repeat MRI 1.5 years after initial study, 9 (38%) demonstrated additional hemorrhages at follow-up. Interrater agreement was high. New hemorrhages were more frequent in patients with probable amyloid angiopathy (8 of 17, 47%) with more hemorrhages at baseline (p < 0.01). These results suggest a role for gradient-echo MRI in assessing disease progression in amyloid angiopathy.
Greenberg
S M
SM
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
O'Donnell
H C
HC
Schaefer
P W
PW
Kraft
E
E
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies