[Expression of CD44 variant isoform in urine samples of urothelial cancer patient].
CD44v8-10 variant isoform is frequently expressed in many kinds of cancers. We have already reported that 77% of bladder cancer specimens expressed CD44v8-10 and using CD44v8-10/CD44v10 competitive reverse transcription-polymerase chain reaction (CC-RT-PCR), we detected exfoliated urothelial cancer cells in urine samples of urothelial cancer patients (Int J Cancer 79: 560, 1998, J Urol 160: 2004). In this paper, we review the expressing of CD44 variant isoform in various kinds of cancers, and the principle of CC-RT-PCR which can be a novel screening method for urothelial cancer.
Hara
I
I
Department of Urology, School of Medicine, Kobe University.
Miyake
H
H
Gohji
K
K
Arakawa
S
S
Kamidono
S
S
D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics / Q000652:urine*; D020033:Protein Isoforms / Q000235:genetics / Q000652:urine; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D018960:Hyaluronan Receptors; D020033:Protein Isoforms