Activity of vinorelbine on B-chronic lymphocytic leukemia cells in vitro.
Vinorelbine (VNR) is a new semi-synthetic Vinca rosea alkaloid that has been employed both in combination and as a single agent, showing a significant antitumour activity. Since little is known about VNR in human leukemia, we studied the in vitro cytotoxic effect of VNR on peripheral blood lymphocytes from 18 patients affected by B-chronic lymphocytic leukemia (CLL), employing the INT assay. VNR inhibited fresh B-CLL cells from 15/18 patients in primary cultures, the ID50 doses ranging from 4 ng/ml to 83 micrograms/ml. These data strongly suggest that VNR could be effective in the treatment of B-CLL.
Bernabei
P A
PA
Università degli Studi-Azienda Ospedaliera di Careggi, Firenze, Italy.
Landini
I
I
Bartolozzi
B
B
Banchelli
I
I
Degli Innocenti o Nocentini
A
A
Santini
V
V
Ematologia
U O
UO
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D001402:B-Lymphocytes / Q000187:drug effects / Q000473:pathology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000633:toxicity; D000077235:Vinorelbine
D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine