title: No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population.
abstract: A polymorphism in intron 8 of the presenilin-1 (PS-1) gene has been demonstrated to increase the risk for developing late-onset Alzheimer disease (AD). Conflicting results exist for the association between this intronic polymorphism and AD probably due to variations in the PS-1 gene among different ethnic groups. We investigated the genetic association between this intronic polymorphism in the PS-1 gene and AD in a homogenous group of German Caucasians. The control group consisted of healthy subjects and depressed patients. There were no significant differences in the distribution of the PS-1 genotypes and allele frequencies between AD patients and controls. Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele.
authors.affiliation: Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany. bagli@uni-bonn.de
authors.forename: M
authors.initials: M
authors.lastname: Bagli
authors.forename: A
authors.initials: A
authors.lastname: Papassotiropoulos
authors.forename: S G
authors.initials: SG
authors.lastname: Schwab
authors.forename: F
authors.initials: F
authors.lastname: Jessen
authors.forename: M L
authors.initials: ML
authors.lastname: Rao
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: R
authors.initials: R
authors.lastname: Heun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D003863:Depression / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D053764:Presenilin-1
chemical_list: D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1