title: Using the spleen for time-delay correction of the input function in measuring hepatic blood flow with oxygen-15 water by dynamic PET.
abstract: By the spleen, we calculated a time-delay correction of the input function for quantitation of hepatic blood flow with oxygen-15 water and dynamic positron emission tomography. The time delay (deltat) between the sample site and the spleen was calculated based on nonlinear multiple regression analysis when splenic blood flow was determined. Then hepatic blood flow was quantified by a method using the input function and incorporating deltat, which was assumed to be equal to the time delay between the sample site and the liver. Then hepatic arterial and portal blood flows were estimated separately as well as the delay time for passage within the organs of the portal circulation. The mean coefficient of variation and the mean sum of squares of errors decreased to about 70% when total hepatic blood flow was calculated from the results for regions of interest in three slices of the same liver segment. We concluded that using the spleen for time-delay correction of the input function for measuring hepatic blood flow by this method gave satisfactory results.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan. taniguchi@1surg.kpu-m.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Taniguchi
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Kunishima
authors.forename: T
authors.initials: T
authors.lastname: Koh
authors.forename: M
authors.initials: M
authors.lastname: Masuyama
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: A
authors.initials: A
authors.lastname: Oguro
authors.forename: H
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006499:Hepatic Artery / Q000502:physiology; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008102:Liver Circulation; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics*; D011169:Portal Vein / Q000502:physiology; D012016:Reference Values; D013154:Spleen / Q000098:blood supply / Q000000981:diagnostic imaging*; D013997:Time Factors; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D010104:Oxygen Radioisotopes