Diphosphoinositol polyphosphates: the final frontier for inositide research?
The diphosphoinositol polyphosphates comprise a group of highly phosphorylated compounds which have a rapid rate of metabolic turnover through tightly-regulated kinase/phosphohydrolase substrate cycles. The phosphohydrolases occur as multiple isoforms, the expression of which is apparently carefully controlled. Cellular levels of the diphosphoinositol polyphosphates are regulated by cAMP and cGMP in a protein kinase-independent manner. These inositides can also sense a specific mode of intracellular Ca2+ pool depletion. In this review, we will argue that these are characteristics of highly significant cellular molecules.
Safrany
S T
ST
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Caffrey
J J
JJ
Yang
X
X
Shears
S B
SB
D017766:Acid Anhydride Hydrolases / Q000378:metabolism; D007295:Inositol Phosphates / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D010766:Phosphorylation; D015398:Signal Transduction
D007295:Inositol Phosphates; D017766:Acid Anhydride Hydrolases; C116368:diphosphoinositol polyphosphate phosphohydrolase