Renin in exocrine glands of different mouse strains.
The renin-angiotensin system (RAS) controls the regulation of blood pressure and water-mineral balance. Recently, renin has been reported to be synthesized and secreted outside the kidney. The present study investigated immunohistochemically the distribution of renin in exocrine glands, i.e. salivary glands and coagulating glands, in male mice of 13 strains. In some strains, renin was detected in the sublingual and submandibular salivary glands, but not in the parotid glands. It was restricted to the striated or granular portions of excretory ducts. In coagulating glands, variable staining patterns were found. These results demonstrate the existence of variations in renin content in mouse strains and offered a selection of mouse strains for investigation of exocrine gland renin.
Kon
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Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. y-kon@vetmed.hokudai.ac.jp
Endoh
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D000818:Animals; D005088:Exocrine Glands / Q000166:cytology / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains / Q000378:metabolism*; D009115:Muridae; D012083:Renin / Q000378:metabolism*; D012469:Salivary Glands / Q000166:cytology / Q000201:enzymology*; D013045:Species Specificity
D012083:Renin