Novel findings about 24,25-dihydroxyvitamin D: an active metabolite?
The physiological role of 24,25-dihydroxyvitamin D remains controversial. Recent results suggest that 24,25-dihydroxyvitamin D is essential for fracture healing, and binding sites for 24,25-dihydroxyvitamin D have been identified in fracture callus tissue. Mice deficient in the 25-hydroxyvitamin D-24-hydroxylase enzyme provide novel genetic tools in which to study the role of 24,25-dihydroxyvitamin D in bone development and fracture repair.
St-Arnaud
R
R
Genetics Unit, Shriners Hospital for Children, Montréal, Québec, Canada. rst-arnaud@shriners.mcgill.ca
D015650:24,25-Dihydroxyvitamin D 3 / Q000378:metabolism*; D000818:Animals; D001846:Bone Development / Q000502:physiology*; D002117:Calcitriol / Q000378:metabolism; D002356:Cartilage / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency / Q000378:metabolism; D017102:Fracture Healing / Q000502:physiology*; D006801:Humans; D051379:Mice; D013250:Steroid Hydroxylases / Q000172:deficiency / Q000378:metabolism; D065668:Vitamin D3 24-Hydroxylase
D015650:24,25-Dihydroxyvitamin D 3; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D065668:Vitamin D3 24-Hydroxylase; D002117:Calcitriol