[The effect of central serotonin administration on the neurogenic damage to the gastric mucosa due to chronic social stress in inbred mice].
A reiterated negative experience of intermale confrontations for 3 and 10 days resulted in aggravation of neurogenic ulceration of gastric mucosa in defeated males from all strains of mice under study, the number of mucosa erosions being 2-3-fold greater than in winners or control animals. Administration of serotonine into the lateral ventricles increased the number of erosions in intact mice of all genotypes. In experimental groups, a considerable diversity was found in respect to the effects of exogenous serotonine on the gastric mucosa. Following 10 days of the stress, both in winners and losers, a decrease of the gastric mucosa sensitivity to central serotonine was revealed.
Koriakina
L A
LA
Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, Novosibirsk, Russia.
D000374:Aggression / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002908:Chronic Disease; D003220:Conflict, Psychological; D003404:Creatinine / Q000008:administration & dosage*; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000502:physiology*; D012701:Serotonin / Q000008:administration & dosage*; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology*
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine