Serum levels of apoptosis-related molecules in patients with multiple sclerosis and human T-lymphotropic virus Type I-associated myelopathy.
We evaluated the presence of soluble Fas (sFas), Fas ligand (sFasL), and Bcl-2 in the sera of patients with multiple sclerosis (MS) or human T-lymphotropic virus type I (HTLV-1)-associated myelopathy (HAM) using an enzyme-linked immunosorbent assay (ELISA). Patients with MS in the active phase had higher sFas and Bcl-2 levels than had controls (sFas, p < 0.005; Bcl-2, p < 0.05) or patients in the inactive phase (p < 0.05). In addition, significantly increased serum levels of sFas were found in patients with HAM (p < 0.005). Interestingly, levels of sFasL in sera from patients with HAM and MS in the active stage were higher than those from controls or from patients with MS in the inactive stage or from other inflammatory neurologic diseases (OIND), although this was not statistically significant. These results suggest that serum sFas, sFasL, and Bcl-2 may play an important role in the pathogenesis of MS and HAM.
Sakai
T
T
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Inoue
A
A
Koh
C S
CS
Osame
M
M
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000473:pathology / Q000821:virology; D015493:Paraparesis, Tropical Spastic / Q000097:blood* / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood*; D019014:fas Receptor / Q000097:blood*
D008024:Ligands; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor