title: Cardiovascular, autonomic, and plasma catecholamine responses in unilateral and bilateral carotid artery stenosis.
abstract: OBJECTIVE
  To determine impairment of baroreceptor afferent activity, which may affect cardiovascular autonomic function in patients with unilateral and bilateral carotid artery stenosis. Comparison was made with normal subjects and hypertensive patients.
  
  
  METHODS
  A series of cardiovascular autonomic function tests along with plasma noradrenaline (norepinephrine) measurements were performed in 46 patients with carotid artery stenosis (CAS); 23 had unilateral and 23 had bilateral stenosis. Comparison was made with 21 hypertensive patients (with a similar degree of raised blood pressure), and 27 normal subjects.
  
  
  RESULTS
  Over a third of patients with unilateral and bilateral CAS had postural hypotension. Heart rate did not rise appropriately in CAS despite the postural fall in blood pressure. Pressor responses in CAS were preserved. Heart rate responses to respiratory stimuli were attenuated. Plasma noradrenaline concentrations rose normally during head up tilt.
  
  
  CONCLUSIONS
  A substantial proportion with CAS had postural hypotension and attenuated heart rate responses. This was not due to sympathetic vasoconstrictor or cardiac parasympathetic failure, thus suggesting impaired afferent baroreceptor activity, probably secondary to involvement of the carotid sinus. Cardiovascular autonomic testing and assessment of postural hypotension and factors enhancing it may be of clinical relevance in such patients, especially as the symptoms of postural hypotension overlap with those due to thromboembolism.
authors.affiliation: Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Vascular Surgery and Neurology, Imperial College School of Medicine at St Mary's, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Akinola
authors.forename: C J
authors.initials: CJ
authors.lastname: Mathias
authors.forename: A
authors.initials: A
authors.lastname: Mansfield
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Wolfe
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: T
authors.initials: T
authors.lastname: Tegos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001341:Autonomic Nervous System / Q000503:physiopathology*; D002319:Cardiovascular System / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000097:blood* / Q000503:physiopathology*; D002395:Catecholamines / Q000097:blood* / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology
chemical_list: D002395:Catecholamines