title: Heterocyclic amine formation and the impact of structure on their mutagenicity.
abstract: The occurrence and formation of heterocyclic amines in foods is discussed in light of the consistent finding of a new class of imidazopyridines. In addition, a quantitative structure-activity relationship will be presented correlating the potency of these imidazopyridines to predicted chemical properties. Although no strong linear correlation is found between the potency and the chemical properties, a low dipole moment is found to be a qualitative predictor of high mutagenic potency.
authors.affiliation: Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, University of California, Livermore 94551, USA. felton1@ilnl.gov
authors.forename: J S
authors.initials: JS
authors.lastname: Felton
authors.forename: M G
authors.initials: MG
authors.lastname: Knize
authors.forename: F T
authors.initials: FT
authors.lastname: Hatch
authors.forename: M J
authors.initials: MJ
authors.lastname: Tanga
authors.forename: M E
authors.initials: ME
authors.lastname: Colvin
mesh_terms: D007093:Imidazoles / Q000737:chemistry* / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry* / Q000633:toxicity; D011725:Pyridines / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D009153:Mutagens; D011725:Pyridines