title: Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals.
abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a basic 38-amino acid regulatory peptide contained in the adrenal gland and involved in the control of its secretory activity. Bilateral splanchnic-nerve section caused in the rat a significant decrease in PACAP38 adrenal content and concentration, as measured by RIA. In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function.
authors.affiliation: Department of Histology and Embryology, School of Medicine, Poznan, Poland.
authors.forename: W J
authors.initials: WJ
authors.lastname: Ginda
authors.forename: G G
authors.initials: GG
authors.lastname: Nussdorfer
authors.forename: L K
authors.initials: LK
authors.lastname: Malendowicz
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D003714:Denervation; D005260:Female; D009479:Neuropeptides / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017208:Rats, Wistar; D013153:Splanchnic Nerves / Q000502:physiology / Q000601:surgery*; D013563:Sympathectomy, Chemical
chemical_list: C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D016627:Oxidopamine