title: The effects of immunosuppression on the induction and immunogenicity of chemically induced sarcomas.
abstract: The induction of chemically induced sarcomas does not appear to be accelerated by immunosuppression with antilymphocyte serum. Tumors induced in immunosuppressed mice contain tumor-specific transplantation antigens of antigenic strength comparable to that of those produced in normal hosts. Transplanted tumors will appear and grow more quickly in ALS-treated mice. Moreover, ALS pretreatment can block the recognition of and response to tumor-specific transplantation antigens.
authors.affiliation: Department of Surgery, Boston University School of Medicine, Mass., USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Fisher
authors.forename: R C
authors.initials: RC
authors.lastname: Davis
authors.forename: J A
authors.initials: JA
authors.lastname: Mannick
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000961:Antilymphocyte Serum / Q000494:pharmacology; D007165:Immunosuppression Therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation; D011817:Rabbits; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D000961:Antilymphocyte Serum