title: A disproportionate increase in VO2 coincident with lactate threshold during treadmill exercise.
abstract: OBJECTIVE
  The purpose of this study was to assess the relationship between pulmonary VO2 and running speed over a range of exercise intensities. During constant-load cycle exercise above the lactate threshold (Tlac), it has been shown that VO2 does not attain a steady state within 3 min but continues to rise until either a delayed but elevated steady-state VO2 is attained or exhaustion occurs. Since this greater oxygen cost of exercise (V02 slow component) has only been demonstrated at discrete exercise intensities above Tlac, it was hypothesised that the onset of the VO2 slow component would coincide with Tlac during an incremental test if the stage durations were of sufficient length.
  
  
  METHODS
  Five male subjects (mean +/- SD age 31 +/- 2 yr: VO2peak 60.1 +/- 5.8 mL x kg(-1) x min(-1)) performed four identical treadmill tests within an 8-d period. The tests involved the completion of six stages of 7-min duration. Running speed was increased by 0.5 km x h(-1) between stages. In the first test, fingertip capillary blood was sampled at the end of each stage for determination of Tlac. For all tests expired air was collected into Douglas bags from 3.0 to 3.75 min and from 6.0 to 6.75 min of each stage to determine any increase in V02 (deltaVO2) over the duration of the stage.
  
  
  RESULTS
  The mean deltaVO2 for each stage over the four tests was determined for each subject. Repeated measures ANOVA with post-hoc Tukey tests revealed a significant increase in deltaVO2 at running speeds above, but not below, Tlac.
  
  
  CONCLUSIONS
  The results of this study confirm the close association between the VO2 slow component and the onset of lactic acidosis and demonstrate alinearity in the VO2-exercise intensity relationship above Tlac for incremental treadmill exercise.
authors.affiliation: Department of Exercise and Sport Science, Crewe and Alsager Faculty, the Manchester Metropolitan University, Alsager, United Kingdom. A.M.Jones@mmu.ac.uk
authors.forename: A M
authors.initials: AM
authors.lastname: Jones
authors.forename: H
authors.initials: H
authors.lastname: Carter
authors.forename: J H
authors.initials: JH
authors.lastname: Doust
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D012420:Running / Q000502:physiology*
chemical_list: D019344:Lactic Acid