Strength of colonic anastomoses and skin incisional wounds in old rats - influence by diabetes and growth hormone.
The influence of advanced age on the mechanical strength of colonic anastomoses and skin incisional wounds in diabetic rats was investigated after 0 (suture binding capacity) and after 7 days of healing. Furthermore, the effects of growth hormone (GH) injections to old diabetic rats were investigated. Diabetes in old rats did not influence the strength of colonic anastomoses after 0 and 7 days. However, in these diabetic animals, the strength of skin incisional wounds was reduced by 27% after 7 days of healing (P< 0.01). GH injections administered to old diabetic rats doubled the mortality compared with that of saline-injected old diabetic rats (P< 0.01). GH injections did not influence the strength formation of either colonic anastomoses or skin incisional wounds in old normal rats. In conclusion, the healing of colonic anastomoses in diabetic rats was not compromised by old age, while the strength of skin wounds was decreased.
Seyer-Hansen
M
M
Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Denmark. tta@ana.au.dk
Andreassen
T T
TT
Oxlund
H
H
D000007:Abdominal Injuries / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000714:Anastomosis, Surgical; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003106:Colon / Q000601:surgery*; D062109:Dermatologic Surgical Procedures; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism* / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries; D015996:Survival Rate; D013718:Tensile Strength; D014945:Wound Healing / Q000187:drug effects
D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone