title: Whole blood and plasma amino acid transfers across the portal drained viscera and liver of the pig.
abstract: Whole blood (WB) and plasma (P) amino acid transfers across the portal drained viscera and the liver were determined during 6 h of a constant p-aminohippuric acid infusion in three hourly-fed Landrace x Large-White pigs (30.5 kg, mean live weight) surgically prepared with chronically inserted catheters in a mesenteric vein (MV), the portal vein (PV), an hepatic vein (HV) and the carotid artery (CA). Plasma and WB amino acid concentrations were determined in the CA, PV and HV. The plasma/WB ratios showed no significant differences for vessels except for lysine and glutamate for which this ratio is significantly higher in the HV and in the PV for lysine. This suggests that the PV lysine and HV glutamate were preferentially transported in the plasma. In the PV, threonine, valine and alanine are transported by both plasma and red blood cells. These data show that the contribution of plasma and whole blood to amino acid transport can be different between amino acids and between individual tissues.
authors.affiliation: Station de recherches porcines, Inra, Saint-Gilles, France. lefloch@st-gilles.rennes.inra.fr
authors.forename: N
authors.initials: N
authors.lastname: Le Floc'h
authors.forename: N
authors.initials: N
authors.lastname: Mézière
authors.forename: B
authors.initials: B
authors.lastname: Sève
mesh_terms: D000409:Alanine / Q000097:blood; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001224:Aspartic Acid / Q000097:blood; D001692:Biological Transport; D018698:Glutamic Acid / Q000097:blood; D005973:Glutamine / Q000097:blood; D006503:Hepatic Veins; D008239:Lysine / Q000097:blood; D008642:Mesenteric Veins; D010949:Plasma / Q000378:metabolism*; D011169:Portal Vein; D013552:Swine / Q000097:blood*; D013912:Threonine / Q000097:blood; D014633:Valine / Q000097:blood; D010130:p-Aminohippuric Acid
chemical_list: D000596:Amino Acids; D005973:Glutamine; D013912:Threonine; D001224:Aspartic Acid; D018698:Glutamic Acid; D014633:Valine; D008239:Lysine; D000409:Alanine; D010130:p-Aminohippuric Acid