title: Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
abstract: This study investigates the antinociceptive and antihyperalgesic action caused by i.p., i.t. or i.c.v. injections of amiloride when assessed against formalin, capsaicin-induced licking, acetic acid-induced writhing and glutamate-induced hyperalgesia in mice. The systemic, spinal and supraspinal administration of amiloride causes dose-related antinociception when assessed against acetic acid-induced writhing, formalin and capsaicin-induced licking. In addition, amiloride administered by the same routes produced graded inhibition of glutamate-induced hyperalgesia in mice. Together, these results suggest, that amiloride or its derivatives may constitute a strategy for the development of new antinociceptive drugs.
authors.affiliation: Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis-SC, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Ferreira
authors.forename: A R
authors.initials: AR
authors.lastname: Santos
authors.forename: J B
authors.initials: JB
authors.lastname: Calixto
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D000584:Amiloride / Q000008:administration & dosage*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology; D004195:Disease Models, Animal; D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005557:Formaldehyde / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects
chemical_list: D004232:Diuretics; D005557:Formaldehyde; D018698:Glutamic Acid; D000584:Amiloride; D019342:Acetic Acid; D002211:Capsaicin