[Assessment of the brainstem and the cerebellar lesions and myelination using magnetic resonance images in children with Down syndrome].
Magnetic resonance images were carried out in the children with Down syndrome aged 2-4 years old compared with the values of the age-matched controls. The pons and cerebellar vermis were significantly smaller and the cerebral peduncles were narrower in Down syndrome. None of the patients showed delay of myelination. These findings suggest hypoplasia of the pons and cerebellum in Down syndrome.
Komaki
H
H
Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo.
Hamaguchi
H
H
Hashimoto
T
T
D001933:Brain Stem / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology*; D002675:Child, Preschool; D004314:Down Syndrome / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016555:Matched-Pair Analysis; D009186:Myelin Sheath / Q000473:pathology*