[Variability of the structure of neurotoxins from the scorpion Orthochirus scrobiculosus from various natural habitats].
To study the structural variability of the Os3 neurotoxin from the venom of scorpion Orthochirus scrobiculosus inhabiting Uzbekistan and Turkmenia, a cloning method for the family of cDNAs that encode the highly homologous Os3-like polypeptides was developed. The Turkmenian scorpion venom was shown to contain a family of closely related Os3-like polypeptides. Mass-spectrometry indicated that crude venoms from scorpions in-habiting these two regions of Central Asia differ in the amino acid composition of their toxic components depending on the habitat.
Lipkin
A V
AV
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. lipus@ibch.siobc.ras.ru
Grishin
E V
EV
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D012604:Scorpion Venoms / Q000737:chemistry*; D012605:Scorpions / Q000145:classification*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D018076:DNA, Complementary; D009498:Neurotoxins; D010455:Peptides; D012604:Scorpion Venoms; C121713:neurotoxin Os3 protein, Orthochirus scrobiculosus