title: A preliminary investigation of alternatives to fumagillin for the treatment of Loma salmonae infection in rainbow trout.
abstract: The effects of the following six treatments against Loma salmonae, a microsporidian gill pathogen, were examined in rainbow trout: fumagillin (high dose), pyrimethamine + sulphaquinoxaline, albendazole, amprolium, fumagillin (low dose), and metronidazole. The fish were infected by mouth and the treatments were administered at intervals for a period of several weeks. The results were assessed on the basis of (1) delay in the formation of xenomas, and (2) the number of xenomas per gill arch. The first five treatments, in descending order of efficacy, delayed the formation of xenomas (P<0.01), but metronidazole had no such effect. Fumagillin (high or low dose) and albendazole both reduced the number of xenomas present 10 weeks after infection (P<0.01), but the other three treatments did not do so. From these results, both fumagillin and albendazole appeared to be of potential value in controlling L. salmonae infection in trout.
authors.affiliation: Department of Pathology and Microbiology, Atlantic Veterinary College, Charlottetown, Prince Edward Island, C1A 4P3, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Speare
authors.forename: F
authors.initials: F
authors.lastname: Athanassopoulou
authors.forename: J
authors.initials: J
authors.lastname: Daley
authors.forename: J G
authors.initials: JG
authors.lastname: Sanchez
mesh_terms: D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000627:therapeutic use*; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D016881:Microsporidiosis / Q000188:drug therapy / Q000662:veterinary*; D017686:Oncorhynchus mykiss / Q000469:parasitology*; D012717:Sesquiterpenes; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D003510:Cyclohexanes; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; C026211:fumagillin; D015766:Albendazole