title: Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials.
abstract: The availability of robust quantitative biological markers that are correlated with qualitative psychiatric phenotypes can potentially improve the power of linkage methods to detect quantitative-trait loci influencing psychiatric disorders. We apply a variance-component method for joint multipoint linkage analysis of multivariate discrete and continuous traits to the extended pedigree data from the Collaborative Study on the Genetics of Alcoholism, in a bivariate analysis of qualitative alcoholism phenotypes and quantitative event-related potentials. Joint consideration of the DSM-IV diagnosis of alcoholism and the amplitude of the P300 component of the Cz event-related potential significantly increases the evidence for linkage of these traits to a chromosome 4 region near the class I alcohol dehydrogenase locus ADH3. A likelihood-ratio test for complete pleiotropy is significant, suggesting that the same quantitative-trait locus influences both risk of alcoholism and the amplitude of the P300 component.
authors.affiliation: Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. jeffw@darwin.sfbr.org
authors.forename: J T
authors.initials: JT
authors.lastname: Williams
authors.forename: H
authors.initials: H
authors.lastname: Begleiter
authors.forename: B
authors.initials: B
authors.lastname: Porjesz
authors.forename: H J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: T
authors.initials: T
authors.lastname: Reich
authors.forename: A
authors.initials: A
authors.lastname: Goate
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: L
authors.initials: L
authors.lastname: Almasy
authors.forename: J
authors.initials: J
authors.lastname: Blangero
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology*; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D018913:Event-Related Potentials, P300 / Q000235:genetics* / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D010375:Pedigree; D019655:Quantitative Trait, Heritable
chemical_list: D000426:Alcohol Dehydrogenase