title: Reversible pancreatitis, hepatitis, and peripheral polyneuropathy associated with parenteral gold therapy.
abstract: A 63-year-old man with seronegative rheumatoid arthritis developed acute pancreatitis, severe hepatitis, and sensorimotor polyneuropathy after receiving 150 mg of intramuscular aurothioglucose (gold). Positive lymphocyte transformation test to gold indicated a cell mediated hypersensitivity to the drug, while multiple investigations ruled out other underlying causes for his illness. After cessation of gold therapy a complete recovery occurred.
authors.affiliation: Department of Internal Medicine C, Rambam Medical Center, Haifa, Israel. mdhaim@tx.technion.ac.il
authors.forename: H
authors.initials: H
authors.lastname: Ben-Ami
authors.forename: S
authors.initials: S
authors.lastname: Pollack
authors.forename: P
authors.initials: P
authors.lastname: Nagachandran
authors.forename: I
authors.initials: I
authors.lastname: Lashevsky
authors.forename: D
authors.initials: D
authors.lastname: Yarnitsky
authors.forename: Y
authors.initials: Y
authors.lastname: Edoute
mesh_terms: D000208:Acute Disease; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D017612:Gold Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012075:Remission, Spontaneous
chemical_list: D017612:Gold Compounds