[The modelling of the glycolytic oscillations in the potential of the oxidative-reductive status of the brain tissue in waking and anesthetized rats].
It was found that chemical hypoxia created by intraperitoneal injection of potassium cyanide (5-7 mg/kg) induced in both waking and anaesthetized (pentobarbital, 40 mg/kg) albino rats a significant decrease in the brain redox state potential (E) monitored with platinum electrodes. This decrease could be accompanied by a generation in some brain points of local chains of gradually damped quasisinusoidal E oscillations. Such oscillations were more expressed in waking than in anaesthetized animals. The frequency range of these oscillations was 4-7 cycles/min. This is the range of overlapping frequency ranges characteristic for the high level of vigilance (5-20 cycles/min) and slow-wave sleep and drowsiness (1.5-6 cycles/min). The amplitude of the observed oscillations was close to the maximal amplitude of the brain E oscillations characteristic for the high level of vigilance (up to several mV). The obtained evidence favors our suggestion that behavior-related E oscillations are formed by the oscillations in the redox balance of glycolysis. The similarity of the normal physiological oscillations and those simulated by us under abnormal conditions suggest a certain common mechanism of their generation.
Shvets-Ténéta-Guriĭ
T B
TB
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Aleksandrov
V I
VI
Dubinin
A G
AG
Mats
V N
VN
Novikova
M R
MR
Troshin
G I
GI
D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004567:Electrodes, Implanted; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006019:Glycolysis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008959:Models, Neurological; D010084:Oxidation-Reduction / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D051381:Rats; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D004791:Enzyme Inhibitors; D011190:Potassium Cyanide