title: Preoperative and postoperative topical tretinoin on high-tension excisional wounds and full-thickness skin grafts in a porcine model: A pilot study.
abstract: BACKGROUND
  Tretinoin induces neovascularization and the formation of collagen when applied topically.
  
  
  OBJECTIVE
  The goal was to determine whether preoperative and postoperative treatment with tretinoin enhances the healing of high-tension, full-thickness excisional wounds and the survival of full-thickness skin grafts.
  
  
  METHODS
  A blinded, randomized, placebo-controlled pilot study involved high-tension excisional wounds and full-thickness skin grafts treated perioperatively with tretinoin in a porcine model.
  
  
  RESULTS
  Perioperative treatment of high-tension excisional surgery sites with tretinoin appeared to have no consistent beneficial or adverse effects on wound healing or scar spreading. In the full-thickness skin graft model, a trend toward impaired wound healing was noted.
  
  
  CONCLUSIONS
  The collagen-inducing effects of topical tretinoin do not appear to enhance the healing of high-tension excisional surgery wounds in a porcine model. Tretinoin does not appear to improve the survival of full-thickness skin grafts and, in fact, a detrimental effect was apparent in our model.
authors.affiliation: Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Otley
authors.forename: S M
authors.initials: SM
authors.lastname: Gayner
authors.forename: I
authors.initials: I
authors.lastname: Ahmed
authors.forename: E J
authors.initials: EJ
authors.lastname: Moore
authors.forename: R K
authors.initials: RK
authors.lastname: Roenigk
authors.forename: D A
authors.initials: DA
authors.lastname: Sherris
mesh_terms: D000287:Administration, Topical; D000818:Animals; D006085:Graft Survival; D010865:Pilot Projects; D011182:Postoperative Care; D011300:Preoperative Care; D016038:Skin Transplantation; D013552:Swine; D013556:Swine, Miniature; D020858:Tissue and Organ Harvesting; D014212:Tretinoin / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D014212:Tretinoin