title: Deconstructing heme.
abstract: Heme degradation plays important biological roles, ranging from generating light-absorbing compounds in plants to facilitating iron homeostasis in mammals. The X-ray crystal structure of human heme oxygenase-1, which instigates the degradation process, reveals insights into the enzymatic mechanism of this important process.
authors.forename: S I
authors.initials: SI
authors.lastname: Beale
authors.forename: J I
authors.initials: JI
authors.lastname: Yeh
mesh_terms: D000818:Animals; D001665:Binding Sites; D002244:Carbon / Q000737:chemistry / Q000378:metabolism; D003460:Crystallization; D018360:Crystallography, X-Ray; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000737:chemistry* / Q000378:metabolism*; D051547:Heme Oxygenase-1; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins; D011487:Protein Conformation; D017510:Protein Folding; D012995:Solubility; D013379:Substrate Specificity
chemical_list: D008024:Ligands; D008565:Membrane Proteins; D006418:Heme; D002244:Carbon; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1