Tyrosine kinase A-nerve growth factor receptor is antigenically present in dystrophic neurites from a variety of conditions but not in Alzheimer's disease.
Tyrosine kinase A (TrkA), a high affinity receptor for nerve growth factor (NGF), is activated during differentiation and regeneration of selective neuronal population. We investigated presence, distribution and expression of TrkA in frontal cortex from cases with Alzheimer's disease (AD), normal aging and a variety of conditions (AIDS, cystic fibrosis, cerebral infarcts) in which neuroaxonal dystrophy occurs. TrkA was immunocytochemically detected in 90% of dystrophic neurites surrounding amyloid deposits in normal aging, as well as in all not amyloid-related dystrophic neurites identified by ubiquitin immunoreactivity. Conversely, the amyloid associated dystrophic neurites were not TrkA reactive in AD tissue. The levels of TrkA protein and mRNA in AD frontal cortex did not significantly differ from those of non-demented aged controls. The absence of TrkA activation in amyloid associated neurites in AD, but not in normal aging, indicates a different reaction of neuronal tissue to amyloid (protein (Abeta) deposition, and suggests that other factors, besides Abeta, mediate neuronal degeneration in AD.
Marinelli
L
L
Department of Neuroscience, University of Genova, Italy.
Cammarata
S
S
Nobbio
L
L
Schenone
A
A
Zaccheo
D
D
Angelini
G
G
Tabaton
M
M
D015526:AIDS Dementia Complex / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D002544:Cerebral Infarction / Q000378:metabolism; D003550:Cystic Fibrosis / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009136:Muscular Dystrophies / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000378:metabolism; D058225:Plaque, Amyloid / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D020917:Receptor, trkA / Q000378:metabolism*; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism
D012333:RNA, Messenger; D017475:Receptors, Nerve Growth Factor; D014452:Ubiquitins; D020917:Receptor, trkA