Spontaneous Formation of the Bioactive Form of the Tuberculosis Drug Isoniazid.
It works even without the enzyme: The formation of the bioactive form 1 of isoniazid inside Mycobacterium tuberculosis does not depend on specific interactions within the active site of the inhibited enzyme, but rather relies on the fast addition of acyl radicals to electron-deficient heterocycles such as NAD(+).
Wilming
M
Lehrstuhl für Organische Chemie I der Universität, Universitätsstrasse 150, D-44780 Bochum (Germany).
Johnsson
K