title: Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonylpiperidin-1-yl)alkanes as potent antiarrhythmic agents.
abstract: Synthesis and SAR studies of the title compounds have resulted in the identification of structural and physicochemical parameter (Vw) contributing for antiarrhythmic activity. Among the two most promising compounds 3a & 3b, the 3a has shown antiarrhythmic activity comparable to quinidine.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: R C
authors.initials: RC
authors.lastname: Tripathi
authors.forename: S K
authors.initials: SK
authors.lastname: Pandey
authors.forename: K
authors.initials: K
authors.lastname: Kar
authors.forename: M
authors.initials: M
authors.lastname: Dikshit
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004562:Electrocardiography; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000889:Anti-Arrhythmia Agents; D010880:Piperidines