Convulsions and respiratory arrest in association with desmopressin administration for the treatment of a bleeding tonsil in a child with borderline haemophilia.
Desmopressin (DDAVP) may be used to augment the action of factor VIII in mild haemophilia. Its use has been associated with serious adverse effects. We report a case of a three-year-old child with a family history of haemophilia who suffered complications due to severe acute hyponatraemia following the administration of this drug for post-tonsillectomy bleeding.
Francis
J D
JD
Department of Anaesthesia and Intensive Care, Bedford Hospital, England.
Leary
T
T
Niblett
D J
DJ
D000233:Adenoidectomy / Q000009:adverse effects; D001049:Apnea / Q000139:chemically induced*; D016063:Blood Loss, Surgical; D002675:Child, Preschool; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000009:adverse effects*; D005169:Factor VIII / Q000008:administration & dosage / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications*; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D008297:Male; D019106:Postoperative Hemorrhage / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced*; D014068:Tonsillectomy / Q000009:adverse effects*
D006490:Hemostatics; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin