title: [Study of chronic graft-vs-host disease, infection and immune reconstitution in patients surviving more than one year after bone marrow transplantation from unrelated donors].
abstract: We studied the immune reconstitution and incidence of chronic graft-vs-host disease (GVHD) and infection in 25 patients who survived more than 1 year after bone marrow transplantation (BMT) from unrelated donors for treatment of leukemia. Of the 25 patients, 4 died after 1 year post-transplantation. The causes of death were relapse of leukemia (2 patients), obstructive bronchiolitis (1 patient), and hepatic failure (1 patient). Only 2 of 14 patients who were under 30 years of age at the time of their BMT developed chronic GVHD, however, 7 of 11 patients 30 years of age or older developed chronic GVHD. Lower karnofsky scores were displayed by 6 of the older patients with chronic GVHD but by none of the younger patients with chronic GVHD. These results underscored the importance of care for older patients with chronic GVHD.CD4-positive T cells, and especially CD4 * CD45RA-positive T cells, had not recovered to a normal range even 2 years after BMT. Longer follow-up will be necessary.
authors.affiliation: Department of Hematology and Bone Marrow Transplantation Center, Meitetsu Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Sao
authors.forename: K
authors.initials: K
authors.lastname: Kitaori
authors.forename: C
authors.initials: C
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: H
authors.initials: H
authors.lastname: Yamanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Morishima
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000401:mortality; D002908:Chronic Disease; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000453:epidemiology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D015994:Incidence; D007239:Infections / Q000453:epidemiology*; D008875:Middle Aged; D015996:Survival Rate; D016176:T-Lymphocyte Subsets; D013997:Time Factors; D014019:Tissue Donors
chemical_list: D007136:Immunoglobulins