title: Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila ten(m)/odd Oz gene, in the central nervous system.
abstract: Zebrafish ten-m3 and ten-m4 encode proteins highly similar to the product of Drosophila pair-rule gene ten(m)/odd Oz (odz). Their products contain eight epidermal growth factor (EGF)-like repeats that resemble mostly those of the extracellular matrix molecule tenascin. During segmentation period, ten-m3 is expressed in the somites, notochord, pharyngeal arches, and the brain, while expression of ten-m4 is mainly restricted to the brain. In the developing brain, ten-m3 and ten-m4 expression delineates several compartments. Interestingly, ten-m3 and ten-m4 show expression patterns complementary to each other in the developing forebrain and midbrain along both rostrocaudal and dorsoventral axes, depending on developmental stages and locations.
authors.affiliation: Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mieda
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Hirate
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary / Q000032:analysis; D004330:Drosophila; D029721:Drosophila Proteins; D015870:Gene Expression; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D019063:Tenascin / Q000378:metabolism*; D013997:Time Factors; D015027:Zebrafish; D029961:Zebrafish Proteins
chemical_list: D018076:DNA, Complementary; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C089140:Ten-m protein, Drosophila; D019063:Tenascin; D029961:Zebrafish Proteins; C405067:tenm3 protein, zebrafish; C405068:tenm4 protein, zebrafish