Eudesmin inhibits tumor necrosis factor-alpha production and T cell proliferation.
Possible antiinflammatory effects of eudesmin were examined by assessing the effects on tumor necrosis factor (TNF)-alpha production and lymphocyte proliferation as well as cytotoxicity against murine and human macrophages. The compound significantly inhibited TNF-alpha production by lipopolysaccharide (LPS)-stimulated murine macrophage RAW264.7 without displaying cytotoxicity suggesting that eudesmin may inhibit TNF-alpha production without any interference of normal cell function. It also significantly attenuated T cell proliferation stimulated by concanavalin A (Con A) in a dose-dependent manner.
Cho
J Y
JY
R & D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam, Kyunggi-Do, Korea. jae.cho@ucl.ac.uk
Yoo
E S
ES
Baik
K U
KU
Park
M H
MH
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D017705:Lignans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D005663:Furans; D017705:Lignans; D014409:Tumor Necrosis Factor-alpha; C105875:eudesmin