title: Malignant large cell calcifying Sertoli cell tumor of the testis (LCCSCTT). Report of a case in an elderly man and review of the literature.
abstract: Malignant Large Cell Calcifying Sertoli Cell Tumor of the Testis (LCCSCTT) is a rare histological variant of sex cordstromal tumors. It usually arises in young males, sometimes is associated with endocrine abnormalities and has a benign course. It is exceptional in elderly men and the outcome is rarely fatal. We report a case of LCCSCTT in a 73 year-old man with fatal outcome. The tumor involved the right testis and several areas of the tunica albuginea were grossly invaded. Serum levels of HCG, LH and testosterone were normal. Lymphoangiography performed after orchiectomy showed an involvement of the iliac and preaortic lymph nodes. X-ray of the chest showed no lung metastases. A thorough study of the light microscopic, immunohistochemical and ultrastructural appearances was performed. Immunohistochemistry revealed positivity to vimentin, S-100 and NSE. Our observations confirm the previous findings concerning malignant LCCSCTT and point out the histogenesis of the tumor from Sertoli cells.
authors.affiliation: Institute of Pathological Anatomy, University of Bari, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bufo
authors.forename: A
authors.initials: A
authors.lastname: Pennella
authors.forename: G
authors.initials: G
authors.lastname: Serio
authors.forename: M G
authors.initials: MG
authors.lastname: Mastropasqua
authors.forename: G
authors.initials: G
authors.lastname: Cenacchi
authors.forename: H
authors.initials: H
authors.lastname: Rogatsch
authors.forename: G
authors.initials: G
authors.lastname: Mikuz
mesh_terms: D017668:Age of Onset; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002100:Cachexia / Q000209:etiology; D002114:Calcinosis / Q000473:pathology*; D003951:Diagnostic Errors; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009920:Orchitis / Q000175:diagnosis; D012707:Sertoli Cell Tumor / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor