Novel polymorphism in the 5'-untranslated region of the interleukin-4 gene.
We found a novel polymorphism C/T change at position -34 counting from the first ATG codon, of the interleukin-4 (IL-4) gene, located between the TATA box and the first ATG on exon 1. The allelic frequency of this C/T polymorphism in 64 independent Japanese samples was 0.37:0.63. In addition, PCR-restriction fragment length polymorphism analysis revealed that the -34T/T polymorphism was always associated with -590T/T, a known polymorphism that increases IL-4 transcriptional activity.
Takabayashi
A
A
Department of Pediatrics, Kyushu University, Fukuoka, Japan.
Ihara
K
K
Sasaki
Y
Y
Kusuhara
K
K
Nishima
S
S
Hara
T
T
D020121:5' Untranslated Regions / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D003062:Codon / Q000235:genetics; D005091:Exons; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D007564:Japan; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D020121:5' Untranslated Regions; D003062:Codon; D015847:Interleukin-4