Structure and Mechanism in Cinchona Alkaloid Chemistry: Overturning a 50-Year-Old Misconception.
Long-standing errors of the supposedly established literature, including textbooks and data bases have been corrected: The structure of the hetero-cinchona bases in the crystal and in solution (see scheme) and the mechanism of their formation from quinine and quinidine have been elucidated.
Braje
WM
Institut für Organische Chemie der Universität, Schneiderberg 1B, D-30167 Hannover (Germany).
Wartchow
R
Hoffmann
HM