Discontinuation symptoms with nefazodone.
OBJECTIVE
We report a patient who developed discontinuation symptoms following nefazodone cessation.


METHODS
The patient experienced nausea, vomiting, diarrhoea, ataxia, insomnia, marked agitation, headache and flu-like symptoms.


METHODS
She was reluctant to recommence nefazodone and was symptomatically treated with oxazepam.


RESULTS
The patient recovered completely in 10 days.


CONCLUSIONS
Nefazodone discontinuation can result in withdrawal symptoms and therefore needs to be tapered gradually. Those who have experienced discontinuation symptoms with other antidepressants in the past may be at increased risk.
Rajagopalan
M
M
Grampians Psychiatry Services, Ballarat Health Services, Victoria, Australia. mani@giant.net.au
Little
J
J
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D010879:Piperazines; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology*; D014230:Triazoles / Q000009:adverse effects* / Q000627:therapeutic use
D018687:Antidepressive Agents, Second-Generation; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone