Simultaneous determination of water and enediols or thiols in chemical products and drugs not amenable to direct Karl Fischer titration.
A method proposed for determining water and enediols or thiols is based on consecutive titration of the enediols or thiols by a novel reagent and of water by the conventional Karl Fischer reagent in the same cell. The time for both titrations is 8-20 min. The novel reagent consists of iodine, sodium acetate as a base, and potassium iodide in a nonaqueous solvent system. The method is applicable for quality control of chemical products and drugs during their production and trade.
Kuselman
I
I
National Physical Laboratory of Israel (INPL), Jerusalem, Israel. kuselman@ netvision.net.il
Sherman
F
F
Bourenko
T
T
Shenhar
A
A
D001205:Ascorbic Acid / Q000032:analysis; D005990:Glycerol / Q000031:analogs & derivatives / Q000032:analysis; D006018:Glycols / Q000032:analysis*; D007202:Indicators and Reagents; D007455:Iodine; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011193:Potassium Iodide; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019346:Sodium Acetate; D012997:Solvents; D013438:Sulfhydryl Compounds / Q000032:analysis*; D013607:Tablets; D014867:Water / Q000032:analysis*
D006018:Glycols; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D012997:Solvents; D013438:Sulfhydryl Compounds; D013607:Tablets; D014867:Water; D011193:Potassium Iodide; D019346:Sodium Acetate; D007455:Iodine; C009465:thioglycerol; D005990:Glycerol; D001205:Ascorbic Acid