Spin-Echo planar spectroscopic imaging for fast lipid characterization in bone marrow.
Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two-dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
Bao
S
S
Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Guttmann
C R
CR
Mugler
J P
JP
Brookeman
J R
JR
Panych
L P
LP
Kraft
R A
RA
Oshio
K
K
Jaramillo
D
D
Jolesz
F A
FA
Williamson
D S
DS
Mulkern
R V
RV
D000328:Adult; D001853:Bone Marrow / Q000737:chemistry*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007719:Knee Joint / Q000033:anatomy & histology / Q000737:chemistry; D008055:Lipids / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D012016:Reference Values; D013113:Spin Labels; D014280:Triglycerides / Q000032:analysis
D008055:Lipids; D013113:Spin Labels; D014280:Triglycerides