A clinical and pathological study on the characteristics and factors influencing the prognosis of crescentic glomerulonephritis using a cluster analysis.
Crescentic glomerulonephritis (CrGN) is expressed by a rapidly progressive lesion. However, there is no unanimous view on the factors that affect the prognosis. We carried out a follow-up study of 109 CrGN patients consisting of 54 males (age 55.3 +/- 15.7) and 55 females (age 54.0 +/- 16.3) by a cluster analysis using pathomorphological parameters at the time of biopsy, and thus found two categories which were significantly different regarding the speed of progress (P = 0.0249). The component factors of rapidly progressive CrGN included a combination of several factors such as: (i) a high frequency of crescents; (ii) frequent sclerosis and hyalinosis in the glomeruli with crescents; (iii) extensive tubulo-interstitial damage (cellular, fibrocellular and fibrous) in the renal cortex; (iv) hyperproteinuria; (v) high mean blood pressure; and (vi) anemia. Thus, the prognosis of CrGN is regulated by no single factor but instead by a complex combination of mutually associated factors.
Sasatomi
Y
Y
Second Department of Pathology, Fukuoka University School of Medicine, Japan.
Kiyoshi
Y
Y
Takabeyashi
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D016000:Cluster Analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011507:Proteinuria; D012307:Risk Factors; D015996:Survival Rate
D003404:Creatinine