title: Middle ear adenomatous tumor with a predominant neuroendocrine component.
abstract: A primary adenomatous tumor of the middle ear was examined by light microscopy, ultrastructural and immunohistochemical techniques. In support of its extensive neuroendocrine differentiation, was the diffuse detection of neuron-specific enolase (NSE) and positive immunoreaction with antibodies to chromogranin and synaptophysin. The great majority of tumor cells contained neurosecretory granules and intraluminal mucin production could be focally detected. These characteristics confirm the diagnosis of a middle ear adenomatous tumor (MEAT) of a biphasic nature and with a prominent neuroendocrine component.
authors.affiliation: Department of Pathology, Athens Nation University Medical School, Greece.
authors.forename: H
authors.initials: H
authors.lastname: Paraskevakou
authors.forename: A C
authors.initials: AC
authors.lastname: Lazaris
authors.forename: D C
authors.initials: DC
authors.lastname: Kandiloros
authors.forename: K
authors.initials: K
authors.lastname: Papadimitriou
authors.forename: G
authors.initials: G
authors.lastname: Adamopoulos
authors.forename: P S
authors.initials: PS
authors.lastname: Davaris
mesh_terms: D000236:Adenoma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D002864:Chromogranins / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004428:Ear Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D004432:Ear, Middle / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D018358:Neuroendocrine Tumors / Q000201:enzymology / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D002864:Chromogranins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase