[Stereospecific anomalies in DNA structure of Saccharomyces chromosomes IV, VII, VIII, X and XI].
Using an original computer program we analysed complete nucleotide sequences of chromosomes IV, VII, VIII, X and XI in yeast. Data about 5 largest stereospecific anomalies in each chromosome are presented together with those for 5 genes with highest CAI in each chromosome. Clusters of different stereospecific anomalies are demonstrated, including trains of not overlapping anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA (Soidla, Lukina, 1998). Together with confirming the earlier noticed connection between stereospecific anomalies and genes with high expression level (coding mostly proteins of translation machinery of cell and glycolytic enzymes), here we also noticed an obvious high incidence of transcription apparatus genes being located at (or near) largest stereospecific anomalies.
Soĭdla
T R
TR
Institute of Cytology, Russian Academy of Sciences, St. Petersburg.
Lukina
N I
NI
D015825:Chromosomes, Fungal; D003062:Codon / Q000235:genetics; D016681:Genome, Fungal; D005810:Multigene Family; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D012984:Software
D003062:Codon