title: Pediatric renal transplantation from the early 1970's through the cyclosporine years at Policlinico University Hospital of Milan.
abstract: In our 27 years' experience, 268 kidney transplantations have been carried out in 243 patients, who were under age 18 at the time of operation. Most (84.7%) received a cadaver donor graft. Immunosuppressive treatment with Cyclosporine (CsA) of the most recent 190 recipients resulted in a one-year graft survival rate gain from 51.0-86.5% compared with conventional azathioprine and prednisone therapy previously administered. The impact of the donor age was perhaps the main factor determining the outcome of pediatric transplantation, with a one-year graft survival rate ranging from 71.0-94.2% for grafts from donors aged 2-24 months or 11-18 years, respectively. Exvivo reconstruction and variations of the standard technique assure better success in the case of small kidneys (9 cases) or grafts with multiple/damaged arteries (58 cases).
authors.affiliation: Division of Vascular Surgery and Kidney Transplantation, Policlinico University Hospital, IRCCS, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Berardinelli
authors.forename: M
authors.initials: M
authors.lastname: Raiteri
authors.forename: A
authors.initials: A
authors.lastname: Vegeto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007223:Infant; D007558:Italy; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000706:statistics & numerical data*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data; D044465:White People
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine