title: Multiple liver metastases of breast cancer: report of a case successfully treated with hormone-cytokine-chemotherapy.
abstract: The prognosis of patients with hepatic metastasis from breast cancer is usually extremely poor. We present the case of a 39-year-old Japanese woman diagnosed with multiple liver metastasis from breast cancer. A novel approach consisting of hormone-cytokine-chemotherapy with an arterial infusion therapy was carried out. Computed tomography and ultrasonography revealed that the multiple liver metastases were reduced with remaining calcification. Tumor markers decreased rapidly. Complete regression was achieved after these treatments. To date, there has been no relapse during the 8-year follow-up period. These results suggest that the hormone-cytokine-chemotherapy might be a rational modality of treatment against multiple metastatic breast cancer.
authors.affiliation: First Department of Surgery, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Naomoto
authors.forename: H
authors.initials: H
authors.lastname: Sadamori
authors.forename: H
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: T
authors.initials: T
authors.lastname: Yamatsuji
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Hino
authors.forename: H
authors.initials: H
authors.lastname: Isozaki
authors.forename: N
authors.initials: N
authors.lastname: Takakura
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D002291:Carcinoma, Papillary / Q000556:secondary / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D016898:Interferon-alpha / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D017258:Medroxyprogesterone Acetate