Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant condition clinically characterized by behavioral, cognitive, and motor disturbances. Until now, at least 13 different FTDP-17 families that show linkage to chromosome 17q21 have been described. To characterize the FTDP-17 candidate region, flanked by the markers D17S1789 and D17S1804, we constructed a physical map in P1 and PAC clones. A detailed transcript map was generated by positioning known genes and EST clusters to the physical map. In total, we investigated 150 STSs mapped to this region. In addition, novel transcripts were isolated by exon-trapping. We were able to localize 19 known genes and a number of ESTs to this chromosomal region. Furthermore, seven novel genes were identified for which we isolated the full-length sequence.
Froelich
S
S
Section of Geriatric Medicine, Karolinska Institutet, Huddinge, S-14186, Sweden. susanne.froelich@neurotec.ki.se
Houlden
H
H
Rizzu
P
P
Chakraverty
S
S
Baker
M
M
Kwon
J
J
Nowotny
P
P
Isaacs
A
A
Nowotny
V
V
Wauters
E
E
van Baren
M J
MJ
Oostra
B A
BA
Hardy
J
J
Lannfelt
L
L
Goate
A
A
Hutton
M
M
Lendon
C L
CL
Heutink
P
P
D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D003704:Dementia / Q000235:genetics*; D005091:Exons; D020224:Expressed Sequence Tags; D005799:Genes, Dominant; D005819:Genetic Markers; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D020734:Parkinsonian Disorders / Q000235:genetics*; D020161:Physical Chromosome Mapping; D016875:tau Proteins
D017931:DNA Primers; D005819:Genetic Markers; C054369:MAPT protein, human; D008869:Microtubule-Associated Proteins; D016875:tau Proteins