title: [Clinico-laboratory effectiveness of modern ointments with a polyethylene glycol base in the treatment of purulent wounds].
abstract: The 25-year experience with the underbandage treatment of soft tissue purulent wounds of various location and genesis with modern ointments with polyethylene glycol as the basis was analyzed. Levocin, levomecole, dioxycole, 5-percent dioxydinic, 1-percent iodopyronic, 0.5-percent quinifuryl and furagel ointments proved to preserve their high activity against aerobic grampositive and gramnegative flora. 10-percent mafenide acetate ointment had a high selective effect on Pseudomonas aeruginosa. The new ointments nitacid and streptonitole containing nitazole and white streptocide were highly active against both aerobic and anaerobic infections. The use of the ointments with the polyethylene glycol as the basis made it possible to decrease 2 times the period of the patient hospitalization in surgical units and to shorten the terms of the systemic antibacterial therapy. The marked therapeutic effect of such ointments due to their high dehydrating capacity and broad antibacterial spectrum enabled to consider them as the drugs of choice in the local treatment of purulent wounds during the 1st phase of the wound process, trophic and decubic ulcers, infected burns, diabetic and atherosclerotic gangrene, furuncles, carbuncles, mastitis, etc. The ointments in the water soluble vehicle can be as well used with success for the prophylactic treatment of infected wounds after the suture. The multitarget effect of the ointments in the water soluble vehicle and their ability to prevent severe purulent complications permitted to consider them as the 1st order drugs in cases of emergency.
authors.affiliation: A.V. Vishnevsky Institute of Surgery, Russian Academy of Medical Sciences, Moscow.
authors.forename: L A
authors.initials: LA
authors.lastname: Blatun
authors.forename: A M
authors.initials: AM
authors.lastname: Svetukhin
authors.forename: A A
authors.initials: AA
authors.lastname: Pal'tsyn
authors.forename: N A
authors.initials: NA
authors.lastname: Liapunov
authors.forename: V A
authors.initials: VA
authors.lastname: Agafonov
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007753:Laboratories; D008826:Microbial Sensitivity Tests; D009824:Ointments; D011092:Polyethylene Glycols; D016896:Treatment Outcome; D014946:Wound Infection / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D009824:Ointments; D011092:Polyethylene Glycols