title: [Non-conventional fractionation in the irradiation of transitional cell tumors of the urinary bladder].
abstract: OBJECTIVE
  To analyze the potentials of non-conventional fractionated radiotherapy regimens for transitional cell tumors of the urinary bladder.
  
  
  METHODS
  The biological principles and clinical aspects taken into account in the design of non-conventional fractionated radiotherapy and the possibility of incorporating the foregoing to enhance the efficacy of the treatment protocols that are widely utilized are briefly analyzed.
  
  
  RESULTS
  Non-conventional fractionation enhances the results achieved with conventional radiotherapeutic regimens and should be included together with chemotherapy and cystectomy in the treatment of bladder cancer.
  
  
  CONCLUSIONS
  Preservation of the bladder while maintaining or improving the cure rate continues to be the principal aim of treatment in cancer of the urinary bladder. The foregoing can be achieved with chemoradiotherapeutic regimens that include non-conventional fractionation of the radiation dose. A better understanding and knowledge of the factors that may have an influence on the therapeutic response and outcome can enhance patient selection for cystectomy.
authors.affiliation: Servicio de Oncología Radioterápica, Hospital Nuestra Señora de Candelaria, Santa Cruz de Tenerife, España.
authors.forename: A
authors.initials: A
authors.lastname: Villar Rodriguez
authors.forename: J C
authors.initials: JC
authors.lastname: Martínez Cedrés
authors.forename: C
authors.initials: C
authors.lastname: Fuentes Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Espiñeíra Yanes
authors.forename: M D
authors.initials: MD
authors.lastname: Perez Suárez
authors.forename: M A
authors.initials: MA
authors.lastname: Cabezón Pons
authors.forename: C M
authors.initials: CM
authors.lastname: Borque Molinos
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*