Plasma lipid concentrations during episodic occupational stress.
The possibility that stress affects plasma lipid concentrations has been the subject of recent investigation, but the findings are equivocal in nonlaboratory settings. To determine whether psychological stress contributes to variability in plasma lipid concentrations and concomitant changes in health behaviors, the effect of increased work load on plasma lipids and apolipoproteins was examined in 173 lawyers. Plasma cholesterol, triglyceride, and apolipoprotein concentrations were studied during periods of high work load (corresponding to impending tax deadlines) and during periods of usual work load. Self-reports of stress, work load, and time pressure, and cortisol, blood pressure, and heart rate were measured to verify that impending deadlines were associated with increased stress levels. Health behaviors which may affect plasma lipoprotein concentrations, including dietary intake and exercise, were also examined. High work load was accompanied by increases in self-reported work load among lawyers most directly affected by the impending deadlines. Plasma apolipoprotein B and triglycerides increased during periods of high work load (M = 1.9 mg/dL, SD = 10.1 and M = 5.3, SD = 34.4, respectively). No changes in dietary intake and exercise were observed. Psychological stress (high work load) is associated with potentially atherogenic changes in plasma lipid concentrations. While the lipoprotein effect of this short-term work stress is small, the effects of longer-term stress on multiple rise factors including triglycerides and apolipoprotein B could have significance for the development of coronary artery disease.
McCann
B S
BS
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104-2499, USA.
Benjamin
G A
GA
Wilkinson
C W
CW
Retzlaff
B M
BM
Russo
J
J
Knopp
R H
RH
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006339:Heart Rate; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007603:Jurisprudence; D008055:Lipids / Q000097:blood*; D008297:Male; D016273:Occupational Exposure; D012621:Seasons; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood; D014861:Washington; D016526:Workload / Q000523:psychology*
D001053:Apolipoproteins; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D006854:Hydrocortisone