title: Antisecretory effect of peptide YY through neural receptors in the rat jejunum in vitro.
abstract: Basal short circuit current (Isc) was measured in stripped rat jejunum after addition of neural antagonists and of peptide YY (PYY). Basal Isc was slightly (by 10-21%) but significantly inhibited by tetrodotoxin, hexamethonium, idazoxan, and the sigma antagonist BMY 14,802. PYY (10(-7) M) reduced basal Isc by approximately 54%. This inhibition was unchanged by hexamethonium but reduced by 44-68% in the presence of tetrodotoxin, idazoxan, haloperidol, BMY 14,802, and atropine. The Y2 agonist pYY(3-36) was more potent than the Y1 agonist (Leu31,Pro34)PYY. In conclusion, PYY reduces basal Isc in rat jejunum in part through a neural mechanism involving muscarinic receptors, alpha2 adrenoceptors, and sigma receptors and, in part, through a direct effect on enterocytes. The PYY effect seems mainly carried out through Y2-receptor activation.
authors.affiliation: INSERM U410, Faculté de Médecine X. Bichat, Paris, France.
authors.forename: X
authors.initials: X
authors.lastname: Fu-Cheng
authors.forename: A
authors.initials: A
authors.lastname: Souli
authors.forename: J
authors.initials: J
authors.lastname: Chariot
authors.forename: C
authors.initials: C
authors.lastname: Rozé
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D019329:Idazoxan / Q000494:pharmacology; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D008297:Male; D019894:Peptide YY / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D011743:Pyrimidines; C050408:alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol; D019894:Peptide YY; D018738:Hexamethonium; D013779:Tetrodotoxin; D001285:Atropine; D006220:Haloperidol; D019329:Idazoxan