[Dependence of antigenic properties of human and avian influenza A virus NP proteins on strain variations in the amino acid sequence].
Human and avian influenza A strains with a known amino acid sequence of NP protein were studied in radioimmunoprecipitation test with a panel of anti-NP monoclonal antibodies. Two of 7 MAbs (315 and IVE8) reacted with variable epitopes. One of the epitopes was present only in human strains, while the other in both human and avian strains, but absent in gull strains and in one human strain, A/Puerto Rico/8/34 (H1N1). The variations recognized by antibodies 315 and IVE8 correlated with amino acid substitutes in positions 16 and 353, respectively.
Krichevets
S G
SG
Varich
N L
NL
Rudneva
I A
IA
Kaverin
N V
NV
D019943:Amino Acid Substitution; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002460:Cell Line; D004285:Dogs; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D015531:Radioimmunoprecipitation Assay; D013045:Species Specificity; D014758:Viral Core Proteins / Q000737:chemistry / Q000276:immunology*
D000911:Antibodies, Monoclonal; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D014758:Viral Core Proteins