title: Plasma choline concentrations in children requiring long-term home parenteral nutrition: a case control study.
abstract: BACKGROUND
  Low plasma free choline concentration has been associated with elevated serum hepatic aminotransferase concentrations and hepatic steatosis in adults who need home parenteral nutrition (HPN). We sought to determine if plasma free choline is similarly reduced in children who need home total parenteral nutrition (TPN).
  
  
  METHODS
  We compared the plasma free choline concentration in 21 children who required long-term HPN with 31 normal controls. Patients had received HPN for 75 +/- 13 (SD) months (range 3-206 months). All control children ingested a normal, mixed, nonvegetarian diet.
  
  
  RESULTS
  The mean plasma free choline concentration in the children receiving HPN was significantly lower than normal children (6.6 +/- 4.3 vs 8.0 +/- 2.3 nmol/mL, p = .002). Plasma free choline concentration was correlated with age (r = -0.43, p = .049). Using multiple linear regression analysis for age, sex, and squared age (considered in order to account for possible nonlinearity between choline and age), HPN children showed a steady and significant decline in plasma free choline concentration with increased age at the rate of 0.03 nmol/mL per month. Plasma lipid bound choline concentration did not vary with age. No relationship was seen between either plasma free and lipid bound choline concentration and amount of daily IV lipid infusion. A significant negative correlation was observed between plasma free choline concentration and aspartate aminotransferase (AST) and alanine aminostransferase (ALT) (r = -0.72, p = .04 and r = -0.80, p = .02, respectively).
  
  
  CONCLUSIONS
  Our data support the notion that patients who need long-term HPN without significant enteral feeding have a significant risk for the development of choline deficiency with its associated hepatic dysfunction.
authors.affiliation: Division of Pediatric Gastroenterology and Nutrition, UCLA School of Medicine, California, USA.
authors.forename: S
authors.initials: S
authors.lastname: Misra
authors.forename: C
authors.initials: C
authors.lastname: Ahn
authors.forename: M E
authors.initials: ME
authors.lastname: Ament
authors.forename: H J
authors.initials: HJ
authors.lastname: Choi
authors.forename: D J
authors.initials: DJ
authors.lastname: Jenden
authors.forename: M
authors.initials: M
authors.lastname: Roch
authors.forename: A L
authors.initials: AL
authors.lastname: Buchman
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002794:Choline / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D016331:Parenteral Nutrition, Home; D013997:Time Factors
chemical_list: D008055:Lipids; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002794:Choline