Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid.
OBJECTIVE
To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration.


METHODS
31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography.


RESULTS
SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844).


CONCLUSIONS
Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold.
Cekiç
O
O
SSK Ankara Eye Hospital, Department of Vitreoretinal Surgery, Ankara, Turkey.
Batman
C
C
Yasar
U
U
Totan
Y
Y
Basci
N E
NE
Bozkurt
A
A
Zilelioglu
O
O
Kayaalp
S O
SO
D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001826:Body Fluids / Q000378:metabolism*; D015818:Eye Infections, Bacterial / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000601:surgery
D000890:Anti-Infective Agents; D015242:Ofloxacin