Analysis of macromolecular structure and dynamics by electron cryo-microscopy.
Electron cryo-microscopy has yielded a wealth of detailed new information on structures of biological macromolecules ranging from alphabeta-tubulin at 3.7 A resolution to hepatitis B virus at 7.4 A resolution, as well as a number of membrane proteins at 6-8 A resolution. Much of this progress was made possible by recent advances in instrumentation and image processing techniques.
Kühlbrandt
W
W
Max-Planck-Institute of Biophysics, Department of Structural Biology, Heinrich-Hoffmann-Strasse 7, Frankfurt am Main, D-60528, Germany. kuehlbrandt@biophys.mpg.de.
Williams
K A
KA
D000818:Animals; D020285:Cryoelectron Microscopy / Q000379:methods*; D018360:Crystallography, X-Ray / Q000379:methods; D006515:Hepatitis B virus / Q000648:ultrastructure; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy; D008565:Membrane Proteins / Q000648:ultrastructure; D008958:Models, Molecular
D008565:Membrane Proteins