title: ROC analysis of three perfusion display options for ECG-gated perfusion SPECT in severe CAD.
abstract: OBJECTIVE
  The simultaneous computation and display of wall motion and perfusion patterns in a single 3D ventricular model would considerably ease the assessment of ECG-gated Tc-99m-sestamibi SPECT, yet the effect on the accuracy of allocating regional perfusion has so far not been validated.
  
  
  METHODS
  3D perfusion mapping (3D Perfusion/Motion Map Software) was compared to the visual assessment of ungated tomographic slices and polar perfusion mapping (Cedars-Sinai PTQ) by correlation analysis and receiver operating characteristics (ROC) analysis at different cut-off levels for coronary stenoses in 50 patients (11 single-, 22 two-, 16 three-vessel disease). Ungated SPECT data were obtained by adding the intervals prior to reconstruction and displaying conventional tomographic slices. All display options were visually assessed in 8 ventricular segments according to a 4-point scoring system and compared to the graded results of coronary angiography.
  
  
  RESULTS
  All three display options showed a comparable diagnostic performance for the detection of severe stenoses. The diagnostic gain for the detection of stenoses above 59% was highest for ungated tomographic slices, followed by ungated polar mapping and 3D mapping. Regional assessment revealed a limited performance of 3D mapping in the proximal anterior and distal lateral wall. Polar mapping showed a balanced regional performance.
  
  
  CONCLUSIONS
  3D Perfusion mapping provides comparable information to conventional display options with the highest diagnostic strength in severe stenoses. Further improvement of the algorithm is needed in the definition of the valve plane.
authors.affiliation: University Clinic Nuclear Medicine, Vienna. THOMAS.LEITHA@akh-wien.ac.at
authors.forename: T
authors.initials: T
authors.lastname: Leitha
authors.forename: H
authors.initials: H
authors.lastname: Bailer
authors.forename: M
authors.initials: M
authors.lastname: Gwechenberger
authors.forename: M
authors.initials: M
authors.lastname: Pruckmayer
authors.forename: A
authors.initials: A
authors.lastname: Staudenherz
authors.forename: G
authors.initials: G
authors.lastname: Kronik
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging; D006328:Cardiac Catheterization / Q000379:methods; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000592:standards*
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi