title: A polymorphism in the CYP17 gene is associated with male breast cancer.
abstract: The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.
authors.affiliation: University of Edinburgh Department of Pathology, Molecular Medicine Centre, UK.
authors.forename: I E
authors.initials: IE
authors.lastname: Young
authors.forename: K M
authors.initials: KM
authors.lastname: Kurian
authors.forename: C
authors.initials: C
authors.lastname: Annink
authors.forename: I H
authors.initials: IH
authors.lastname: Kunkler
authors.forename: V A
authors.initials: VA
authors.lastname: Anderson
authors.forename: B B
authors.initials: BB
authors.lastname: Cohen
authors.forename: M L
authors.initials: ML
authors.lastname: Hooper
authors.forename: A H
authors.initials: AH
authors.lastname: Wyllie
authors.forename: C M
authors.initials: CM
authors.lastname: Steel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000728:Androgens / Q000097:blood; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology / Q000235:genetics; D018567:Breast Neoplasms, Male / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D004967:Estrogens / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics* / Q000378:metabolism
chemical_list: D000728:Androgens; D004967:Estrogens; D013254:Steroid 17-alpha-Hydroxylase