title: [New concepts in the pathogenesis of essential hypertension].
abstract: In Poland over 40% of patients are hypertensive. Majority of them suffer from essential hypertension. Its pathogenesis despite intensive studies is unclear. Many factors are thought to be involved in the pathogenesis of essential hypertension: sodium intake, obesity with insulin resistance, renin-angiotensin system, sympathetic nervous system as well as genetic factors, low birth weight and endothelial dysfunction. At present, the role of endothelin-1 is emphasized.
authors.affiliation: Kliniki Nefrologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku.
authors.forename: E
authors.initials: E
authors.lastname: Zbroch
authors.forename: J
authors.initials: J
authors.lastname: Małyszko
authors.forename: M
authors.initials: M
authors.lastname: Myśliwiec
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000378:metabolism; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000209:etiology* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009765:Obesity / Q000150:complications; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D012982:Sodium, Dietary
chemical_list: D019332:Endothelin-1; D012982:Sodium, Dietary; D000804:Angiotensin II; D009569:Nitric Oxide