The moving target: mechanisms of HIV persistence during primary infection.
The vigorous host immune responses detected during primary HIV infection fail to prevent the establishment of chronic infection because HIV has evolved multiple strategies to make these responses ineffective. Here, Hugo Soudeyns and Giuseppe Pantaleo discuss the mechanisms that allow HIV to persist in the host.
Soudeyns
H
H
Laboratory of AIDS Immunopathogenesis, Dept of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland.
Pantaleo
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G
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D008213:Lymphocyte Activation; D009154:Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014779:Virus Replication