title: Determination of the tissue attenuation factor along two major axes of a high dose rate (HDR) 192Ir source.
abstract: Quantitative information on photon scattering around brachytherapy sources is needed to develop dose calculation formalisms capable of predicting dosimetric parameters with minimal empiricism. Photon absorption and scatter around brachytherapy sources can be characterized using the tissue attenuation factor, defined as the ratio of dose in water to water kerma in free space. In this study, the tissue attenuation factor along two major axes of a high dose rate (HDR) 192Ir source was determined by TLD measurements and MCNP Monte Carlo calculations. A calculational method is also suggested to derive the tissue attenuation factor along the longitudinal source axis from the factor along the transverse axis, using published anisotropy data as input. TLD and Monte Carlo results agreed with each other for both source axes within the statistical uncertainty (approximately +/- 5%) of Monte Carlo calculations. Comparison with published data, available only for the transverse source axis, also showed good agreement within +/- 5%. The shape and magnitude of the tissue attenuation factor are found to be remarkably different between the two axes. The tissue attenuation factor reaches a maximum value of about 1.4 at 8 cm from the source along the longitudinal source axis, while a maximum value of about 1.04 occurs at 3-4 cm from the source along the transverse axis. The calculated tissue attenuation factor along the longitudinal source axis generally reproduced the TLD and Monte Carlo results within +/- 5% at most radial distances.
authors.affiliation: Department of Radiation Physics, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. scho@mdanderson.org
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: R
authors.initials: R
authors.lastname: Muller-Runkel
authors.forename: W F
authors.initials: WF
authors.lastname: Hanson
mesh_terms: D016880:Anisotropy; D055592:Biophysical Phenomena; D001703:Biophysics; D001918:Brachytherapy / Q000706:statistics & numerical data; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009010:Monte Carlo Method; D017785:Photons; D011880:Radiotherapy Planning, Computer-Assisted; D012542:Scattering, Radiation; D013819:Thermoluminescent Dosimetry
chemical_list: D007496:Iridium Radioisotopes