Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex.
Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
Espey
M G
MG
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ellis
R J
RJ
Heaton
R K
RK
Basile
A S
AS
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D018698:Glutamic Acid / Q000134:cerebrospinal fluid*; D015497:HIV-1; D006801:Humans; D008297:Male
D018698:Glutamic Acid