The Concept of Docking/Protecting Groups in Biohydroxylation.
A general principle for biohydroxylation, in which time-consuming screening and enrichment techniques are avoided, is demonstrated by the introduction of a docking/protecting group into the substrate. This facilitates acceptance by the microorganism and allows the use of a narrow range of microorganisms, for example Beauveria bassiana ATTC 7159 (B. b.), for the hydroxylation of compounds with diverse structures. After the biohydroxylation, the docking/protecting group is removed (see scheme).
Braunegg
G
Spezialforschungsbereich F01 Biokatalyse, Institut für Organische Chemie der Technischen Universität Graz, Stremayrgasse 16, A-8010 Graz (Austria).
de Raadt A
Feichtenhofer
S
Griengl
H
Kopper
I
Lehmann
A
Weber
HJ