Membranous glomerulonephritis induced in the pig by antibody to angiotensin-converting enzyme: considerations on its relevance to the pathogenesis of human idiopathic membranous glomerulonephritis.
In the course of studies on the humoral consequences of swine to primate xenotransplantation, the investigators induced formation of glomerular subepithelial immune deposits and tubular lesions in pigs injected with heterologous antibody to angiotensin-converting enzyme. This study describes the morphology of the lesions, discusses their mechanism, explains their relevance for understanding the pathogenesis of human idiopathic membranous glomerulonephritis, and proposes future directions for investigations.
Maruyama
S
S
Department of Physiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA.
Cantu
E
E
Demartino
C
C
Vladutiu
A
A
Caldwell
P R
PR
Wang
C Y
CY
D'Agati
V
V
Godman
G
G
Stern
D M
DM
Andres
G
G
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004727:Endothelium / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry; D015433:Glomerulonephritis, Membranous / Q000201:enzymology* / Q000276:immunology / Q000473:pathology*; D000882:Haplorhini; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D051379:Mice; D018613:Microscopy, Confocal; D007703:Peptidyl-Dipeptidase A / Q000276:immunology*; D011817:Rabbits; D011863:Radioimmunoassay; D051381:Rats; D012680:Sensitivity and Specificity; D012710:Serum Albumin, Bovine / Q000276:immunology; D013045:Species Specificity; D013552:Swine
D000906:Antibodies; D007074:Immunoglobulin G; D012710:Serum Albumin, Bovine; D007703:Peptidyl-Dipeptidase A