Engineering the mouse genome by site-specific recombination.
Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.
Metzger
D
D
Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS/INSERM/ULP Collége de France BP 163, 67404, Illkirch Cedex, CU de Strasbourg, France. metzger@igbmc.u-strasbg.fr
Feil
R
R
D000818:Animals; D002875:Chromosomes; D020868:Gene Silencing; D005818:Genetic Engineering / Q000379:methods; D005822:Genetic Vectors / Q000235:genetics; D016678:Genome; D019426:Integrases / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D016296:Mutagenesis; D016297:Mutagenesis, Site-Directed; D011995:Recombination, Genetic; D014764:Viral Proteins; D014780:Viruses / Q000235:genetics
D014764:Viral Proteins; C045073:Cre recombinase; D019426:Integrases