[An experimental validation of the use of levomycetin preparations for the treatment of burns infected with Pseudomonas aeruginosa].
Application of 1% of chloramphenicol (gel and cream) for local treatment of Pseudomonas aeruginosa burn infection has been studied in experiment. In vivo, both medical forms show pronounced therapeutic effect, they promote elimination of P. aeruginosa from wounds and decrease inflammation. In noninfected thermal trauma in laboratory animals application of gel and cream of chloramphenicol reduces transition from the phase of inflammation to the phase of reparation by 3-8 days and prevents infection of the burn wound by conditionally pathogenic microflora.
Tkachenko
V L
VL
Kharkov State Medical University, Ukraine.
Tsyganenko
A Ia
AIa
Liapunov
N A
NA
Bezuglaia
E P
EP
Minukhin
V V
VV
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002056:Burns / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D002701:Chloramphenicol / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005782:Gels; D051379:Mice; D008808:Mice, Inbred CBA; D009824:Ointments; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005782:Gels; D009824:Ointments; D002701:Chloramphenicol