title: Dengue epidemic in the State of Rio Grande do Norte, Brazil, in 1997.
abstract: During 1997 a large dengue epidemic occurred in Rio Grande do Norte, a State in north-east Brazil. The co-circulation of dengue virus type 1 and dengue virus type 2 was demonstrated by virus isolation in Aedes albopictus clone C6/36 cell-line and by reverse transcriptase-polymerase chain reaction (RT-PCR). IgM capture enzyme-linked immunosorbent assay confirmed 52.3% of the 8105 studied cases and dengue antigen was demonstrated by immunohistochemical reaction on hepatocytes from 2 out of 5 fatal cases studied. Individual risk factors for development of dengue haemorrhagic fever/dengue shock syndrome, such as hypertension, diabetes mellitus and bronchial asthma, are discussed.
authors.affiliation: Disciplina de Doenças Infecciosas e Parasitárias, Universidade Federal de Mato Grosso do Sul, Rio de Janeiro, Brazil. rivaldoc@alanet.com.br
authors.forename: R V
authors.initials: RV
authors.lastname: Cunha
authors.forename: H G
authors.initials: HG
authors.lastname: Schatzmayr
authors.forename: M P
authors.initials: MP
authors.lastname: Miagostovich
authors.forename: A M
authors.initials: AM
authors.lastname: Barbosa
authors.forename: F G
authors.initials: FG
authors.lastname: Paiva
authors.forename: R M
authors.initials: RM
authors.lastname: Miranda
authors.forename: C C
authors.initials: CC
authors.lastname: Ramos
authors.forename: J C
authors.initials: JC
authors.lastname: Coelho
authors.forename: F B
authors.initials: FB
authors.lastname: dos Santos
authors.forename: R M
authors.initials: RM
authors.lastname: Nogueira
mesh_terms: D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003715:Dengue / Q000175:diagnosis / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008099:Liver / Q000276:immunology; D008297:Male; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
chemical_list: D000956:Antigens, Viral; D007075:Immunoglobulin M