title: Prognostic importance of lymphatic reaction pattern in laryngeal carcinoma.
abstract: OBJECTIVE
  Cervical lymph node status is a widely accepted important prognostic parameter in laryngeal carcinoma.
  
  
  METHODS
  In this study, we retrospectively reviewed neck specimens of 46 laryngeal carcinoma patients operated in our clinic. Presence of neck metastasis and pattern of reactivity in nonmetastatic nodes was correlated with recurrence and survival during a follow-up period of at least 2 years.
  
  
  RESULTS
  Fourteen of the patients had at least one metastatic node and survival was 64%; 32 of the patients had reactional nodes only and the survival was 81%. Pattern of lymph node reactivity was evaluated as stimulated in type I (lymphocyte predominance) and type II (germinal center predominance); as unstimulated in type III (histiocytosis and/or normal) and type IV (lymphocyte depletion). Thirty two neck [-] patients had reactional nodes--16 of them were classified as stimulated and 16 of them as unstimulated; the 2-year survivals were 94% and 68%, respectively. In the 14 patients with cervical metastasis (classified according to nonmetastatic reactional nodes) 9 were stimulated and 5 were unstimulated with 2-year survivals of 100% and 0%, respectively.
  
  
  CONCLUSIONS
  Stimulated lymphatic pattern reflects a better prognosis, especially in N+ neck laryngeal cancer patients.
authors.affiliation: Ministry of Health Ankara Hospital, Ankara-Türkiye. mhkorkmaz@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Korkmaz
authors.forename: M
authors.initials: M
authors.lastname: Caydere
authors.forename: E
authors.initials: E
authors.lastname: Dursun
authors.forename: E
authors.initials: E
authors.lastname: Samim
authors.forename: H
authors.initials: H
authors.lastname: Ustün
authors.forename: H
authors.initials: H
authors.lastname: Göcmen
authors.forename: C
authors.initials: C
authors.lastname: Ozeri
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018572:Disease-Free Survival; D015614:Histiocytosis / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008199:Lymphadenitis / Q000145:classification / Q000473:pathology*; D008207:Lymphatic Metastasis; D016131:Lymphocyte Subsets / Q000473:pathology; D008231:Lymphopenia / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate