Thalidomide-induced toxic epidermal necrolysis.
Toxic epidermal necrolysis (TEN) is a severe dermatologic disorder associated with mortality of up to 30%. Withdrawal of the causative agent is crucial in its management. Although thalidomide-induced dermatologic disorders rarely were reported before thalidomide was administered to patients positive for the human immunodeficiency virus, hypersensitivity reactions including rash are the agent's major dose-limiting toxicities in this population. As it is prescribed for other immunosuppressed patients, such as those with malignancies, the frequency of dermatologic reactions (including TEN) may increase. A 62-year-old woman developed TEN after approximately 5 weeks of thalidomide therapy for the treatment of a glioblastoma.
Horowitz
S B
SB
College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York 11439, USA.
Stirling
A L
AL
D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D005260:Female; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000209:etiology*; D013792:Thalidomide / Q000009:adverse effects*
D020533:Angiogenesis Inhibitors; D013792:Thalidomide