Sense and specificity: a molecular identity for nociceptors.
Recent cloning efforts have identified families of ligand- or voltage-gated ion channels that are expressed by pain-sensing primary afferent neurons. Pharmacological, electrophysiological and genetic studies are beginning to reveal how these signaling molecules specify roles for subsets of sensory neurons in the pain pathway.
Caterina
M J
MJ
Department of Cellular and Molecular Pharmacology University of California - San Francisco, 94143-0450, USA. mcateri@itsa.ucsf.edu
Julius
D
D
D000143:Acids / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D004594:Electrophysiology; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism; D009411:Nerve Endings / Q000502:physiology; D009619:Nociceptors / Q000378:metabolism*; D011955:Receptors, Drug / Q000502:physiology; D015222:Sodium Channels / Q000502:physiology
D000143:Acids; D007473:Ion Channels; D011955:Receptors, Drug; D015222:Sodium Channels; D000255:Adenosine Triphosphate