Anti-Kaposi's sarcoma and antiangiogenic activities of sulfated dextrins.
Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation of endothelial cells into tubes as well as reduce new vessel formation in a placental angiogenesis assay. The antiangiogenic effect of dextrin 6-sulfate is greater than that of dextrin 2-sulfate and is independent of their anti-human immunodeficiency virus type 1 activities.
Thornton
M
M
Departments of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
Barkley
L
L
Mason
J C
JC
Shaunak
S
S
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003912:Dextrins / Q000008:administration & dosage / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007274:Injections, Intraperitoneal; D008208:Lymphatic System / Q000187:drug effects / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D012514:Sarcoma, Kaposi / Q000098:blood supply / Q000188:drug therapy*; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D003912:Dextrins; C091377:dextrin 2-sulfate