title: HLA antigens in patients with variant angina in Japan.
abstract: There have been few reports on examining the susceptibility of variant angina. Accordingly, the major histocompatibility complexes (HLA-A, -B, -C, -DR) of unrelated Japanese patients with variant angina were examined. There were no significant differences in the frequency of HLA-A,-B, -C, and -DR antigens between patients and controls (n = 100). Although endothelial dysfunction with pathological abnormalities is suggested to be one of the etiological factors in vasospasm, immunogenetic abnormalities linked to HLA system might not play a role in the pathogenesis of variant angina.
authors.affiliation: The Second Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan. kkishi@kuhp.kyoto-u.ac.jp
authors.forename: C
authors.initials: C
authors.lastname: Kishimoto
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: E
authors.initials: E
authors.lastname: Maruya
authors.forename: H
authors.initials: H
authors.lastname: Saji
mesh_terms: D000328:Adult; D000368:Aged; D000788:Angina Pectoris, Variant / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged
chemical_list: D006680:HLA Antigens