Clinical aspects of alveolar rhabdomyosarcoma with translocation t(1;13)(p36;q14) and hypotetraploidy.
Although most cases of alveolar rhabdomyosarcoma (RMS) are characterized by the chromosomal translocation t(2;13)(q35;q14), several cases have been reported with a variant t(1;13)(p36;q14). We present the clinical, morphological and cytogenetic features of an alveolar RMS in a 4-year-old boy. Chromosomal analysis revealed a hypertriploid to hypotetraploid karyotype with a t(1;13)(p36;q14) in all tumor cells. It appears that alveolar RMS with t(1;13) occurs in younger children and displays a higher incidence to upper and lower extremity than tumors with t(2;13).
Gunawan
B
B
Georg-August-University, Department of Pathology, Göttingen, Germany.
Füzesi
L
L
Granzen
B
B
Keller
U
U
Mertens
R
R
Steinau
G
G
Schumpelick
V
V
D000782:Aneuploidy; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D018572:Disease-Free Survival; D006801:Humans; D007621:Karyotyping; D008297:Male; D009364:Neoplasm Recurrence, Local; D018232:Rhabdomyosarcoma, Alveolar / Q000235:genetics* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic