title: Detection of hepatic tumor perfusion following transcatheter arterial chemoembolization with dynamic susceptibility contrast-enhanced echoplanar imaging.
abstract: The aim of the study was to evaluate the usefulness of the magnetic resonance (MR) perfusion maps in the detection of liver tumor perfusion following transcatheter arterial chemoembolization (TACE). MR dynamic susceptibility contrast-enhanced imaging was performed in 12 patients with 10 confirmed hepatocellular carcinoma and 2 confirmed hepatic metastasis using single-shot echoplanar pulse sequence. Time-intensity curves for all hepatic tumors showed a transient signal drop and the hepatic blood volume (HBV) maps were reconstructed. On the HBV maps, most tumors (80%) demonstrated hyperperfusion before TACE and hypoperfusion following TACE. The site and the degree of residual hyperperfusion within the tumor on the HBV maps correlated well with the areas of hypervascularity on the angiograms. In conclusion, the MR perfusion maps can be a promising technique for detecting the perfusion of the residual tumor tissue following TACE.
authors.affiliation: Department of Diagnostic Radiology, Tuen Mun Hospital, Hong Kong, People's Republic of China.
authors.forename: J H
authors.initials: JH
authors.lastname: Chan
authors.forename: E Y
authors.initials: EY
authors.lastname: Tsui
authors.forename: S H
authors.initials: SH
authors.lastname: Luk
authors.forename: M K
authors.initials: MK
authors.lastname: Yuen
authors.forename: Y K
authors.initials: YK
authors.lastname: Cheung
authors.forename: K P
authors.initials: KP
authors.lastname: Wong
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D003287:Contrast Media; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000098:blood supply* / Q000628:therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA