Genetic polymorphisms at the tumour necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis.
Many studies have previously confirmed high TNFalpha (tumor necrosis factor-alpha) production in sarcoidosis, and have shown that TNFalpha plays an important role in granuloma formation. We investigated TNFA and TNFB (lymphotoxin-alpha) gene polymorphisms in 26 cardiac sarcoidosis patients of Japanese origin. These studies revealed a significant increase in the more uncommon TNFA2 allele in the patient group, suggesting that the TNFA gene controls the genetic susceptibility to cardiac sarcoidosis.
Takashige
N
N
Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Kanagawa Medicine, Isehara Kanagawa, Japan.
Naruse
T K
TK
Matsumori
A
A
Hara
M
M
Nagai
S
S
Morimoto
S
S
Hiramitsu
S
S
Sasayama
S
S
Inoko
H
H
D044466:Asian People / Q000235:genetics; D009202:Cardiomyopathies / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D007564:Japan; D008233:Lymphotoxin-alpha / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000276:immunology*; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D005819:Genetic Markers; D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha