CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis.
Interleukin-6 (IL-6) has recently been implicated in multiple sclerosis (MS), since IL-6 deficient mice were resistant to a demyelinating form of experimental autoimmune encephalomyelitis and IL-6 expression was upregulated in MS. The cytokine IL-6 and its action mediating soluble receptors (sIL-6R and sgp130) were measured in cerebrospinal fluid (CSF) and serum of 61 MS patients and 39 controls. In the presence of unchanged IL-6 concentrations, sIL-6R and sgp130 serum levels were significantly increased in MS and correlated with disease severity. Furthermore, sgp130 CSF levels were decreased in MS, suggesting a possibly altered IL-6 regulation in the CSF.
Padberg
F
F
Department of Psychiatry, Ludwig-Maximilian University, Munich, Germany. padberg@nk-i.med.uni-muenchen.de
Feneberg
W
W
Schmidt
S
S
Schwarz
M J
MJ
Körschenhausen
D
D
Greenberg
B D
BD
Nolde
T
T
Müller
N
N
Trapmann
H
H
König
N
N
Möller
H J
HJ
Hampel
H
H
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D015703:Antigens, CD / Q000097:blood* / Q000134:cerebrospinal fluid*; D050822:Cytokine Receptor gp130; D004673:Encephalomyelitis, Acute Disseminated / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D019947:Receptors, Interleukin-6 / Q000097:blood; D012995:Solubility
D015703:Antigens, CD; C494199:IL6ST protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130