Oxidative stress mediates apoptosis induced by oxidized low-density lipoprotein and oxidized lipoprotein(a).
We measured oxidative stress caused by lipoproteins in human umbilical vein endothelial cells and rabbit aorta. Oxidized lipoprotein(a) was the more potent stimulus over oxidized low density lipoprotein, and we believe that both influence the pathogenesis of atherosclerosis.
Heermeier
K
K
Department of Medicine, Division of Nephrology, University Hospital of Würzburg, Germany.
Schneider
R
R
Heinloth
A
A
Wanner
C
C
Dimmeler
S
S
Galle
J
J
D000818:Animals; D001011:Aorta / Q000166:cytology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001161:Arteriosclerosis / Q000378:metabolism; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology / Q000201:enzymology; D006801:Humans; D017270:Lipoprotein(a) / Q000378:metabolism / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism / Q000494:pharmacology*; D008244:Lysophosphatidylcholines / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011817:Rabbits; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology
D017270:Lipoprotein(a); D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; D017382:Reactive Oxygen Species; C099252:oxidized low density lipoprotein; D013482:Superoxide Dismutase; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases