title: Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts.
abstract: GB viruses A and C (GBV-A and GBV-C) have been isolated from humans and non-human primates. Phylogenetic analysis based on full-length polyproteins suggests that these two viruses have a common ancestor. It has now been determined that analysis of subgenomic amino acid sequences in the E2 and NS5 regions of GBV-A and a 345 nucleotide segment in the 5' non-coding (5'NC) region was able to reproduce the phylogenetic relationships obtained by complete polyprotein sequences analysis. Using 5'NC sequences from databases, GBV-A isolates were discriminated into eight genetic groups, each one closely associated with specific primate hosts. Phylogenetic analyses performed on sequences from the epsilon-globin genes of primate hosts on one hand and complete polyprotein sequences from GBV-A and GBV-C isolates on the other suggest that a mechanism of cospeciation could be involved in virus evolution over a period of 35 million years.
authors.affiliation: Dept of Pathology, Center for Tropical Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA2.|Laboratoire de Virologie moléculaire, transfusionnelle et tropicale, Faculté de Médecine, 13385 Marseille, France1.
authors.forename: Rémi N
authors.initials: RN
authors.lastname: Charrel
authors.affiliation: Laboratoire de Virologie moléculaire, transfusionnelle et tropicale, Faculté de Médecine, 13385 Marseille, France1.
authors.forename: Philippe
authors.initials: P
authors.lastname: De Micco
authors.affiliation: Laboratoire de Virologie moléculaire, transfusionnelle et tropicale, Faculté de Médecine, 13385 Marseille, France1.
authors.forename: Xavier
authors.initials: X
authors.lastname: de Lamballerie
mesh_terms: D000818:Animals; D018067:Flaviviridae / Q000145:classification*; D006801:Humans; D010802:Phylogeny; D011323:Primates