The molecular basis of T cell differentiation.
Our laboratory has studied the molecular basis of T helper cell differentiation. We have used reporter transgenic mice, selective hybridization techniques, and studies of cell signaling to show that a complex pattern of gene expression is reprogrammed as the decision is made to become either a Th1 or Th2 cell. Many of these components have been identified, and their mechanisms of action elucidated. Understanding these mechanisms is likely to lead in the long-term to ways to intervene in these processes and, therefore, to direct immune response in therapeutically useful directions.
Flavell
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Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT 06520-8011, USA. fran.manzo@yale.edu
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D005786:Gene Expression Regulation; D048031:JNK Mitogen-Activated Protein Kinases; D051379:Mice; D020928:Mitogen-Activated Protein Kinases; D015398:Signal Transduction; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases