Anti-DNA autoantibodies and systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects most of the organs and tissues of the body, causing glomerulonephritis, arthritis, and cerebritis. SLE can be fatal with nephritis, in particular, predicting a poor outcome for patients. In this review, we highlight what has been learned about SLE from the study of mouse models, and pay particular attention to anti-DNA autoantibodies, both as pathological agents of lupus nephritis and as DNA-binding proteins. We summarize the current approaches used to treat SLE and discuss the targeting of anti-DNA autoantibodies as a new treatment for lupus nephritis.
Blatt
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NB
Department of Chemistry, University of Michigan, Ann Arbor 48109-1055, USA.
Glick
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GD
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003429:Cross Reactions; D018736:DNA Adducts; D004195:Disease Models, Animal; D005544:Forecasting; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D051379:Mice; D011506:Proteins / Q000378:metabolism
D000974:Antibodies, Antinuclear; D018736:DNA Adducts; D011506:Proteins