Recombinant baculoviruses as expression vectors for insect and mammalian cells.
Baculovirus expression vectors are widely used for expressing heterologous proteins in cultured insect cells. Recent advances include further development of the system for production of multi-subunit protein complexes, co-expression of protein-modifying enzymes to improve heterologous protein production, and additional applications of baculovirus display technology. The application of modified baculovirus vectors for gene expression in mammalian cells continues to expand.
Kost
T A
TA
Molecular Sciences Department Glaxo Wellcome 5 Moore Drive, Research Triangle Park, NC 27709, USA. tak4306@glaxowellcome.com
Condreay
J P
JP
D000818:Animals; D000941:Antigens / Q000235:genetics / Q000378:metabolism; D016367:Baculoviridae / Q000235:genetics*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D007313:Insecta / Q000821:virology*; D008322:Mammals / Q000821:virology*; D011994:Recombinant Proteins / Q000235:genetics* / Q000378:metabolism; D014614:Vaccines, Synthetic / Q000235:genetics
D000941:Antigens; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic