[The development of the syndrome of congestive parenchymatous organs under conditions of short-term hypokinesia].
Five series of head-down (-10 degrees to -30 degrees, up to 18 hr) tilt tests were performed with participation of 65 healthy male subjects. The ultrasonic technique was used to investigate the liver, spleen, pancreas, kidney, and the main abdominal vessels, i.e. aorta in the abdomen and superior mesenteric artery, interior caval, portal, and splenic veins. A few hours of HDT already brought about a complex of load-deprivation reflexes (the syndrome of stagnant parenchymal organs) characterized by a prolonged venous congestion in the abdominal organs-vessels system, increases in sizes and blood filling of the liver, spleen, pancreas, kidney, and the main arteries and veins in this hemodynamic region. This was the first time when increases in pancreas including its head, body and tail, and the abdominal blood vessels were quantified at the beginning of adaptation to HDT. The load-deprivation reflexes arising in this period were hemodynamic by nature. Considering the significant functional strain of the abdominal organs and vessels and particularly the limited control of excessive blood flow towards the pancreas and kidneys, there is a good reason to look into the ways to improve the existing countermeasures against the consequences of immobilization for humans both in general clinic and preventive medicine, and in short- and long-term space missions.
Bednenko
V S
VS
Stupakov
G P
GP
Nesterov
M A
MA
Mukhin
V A
VA
D000005:Abdomen / Q000098:blood supply* / Q000000981:diagnostic imaging; D000222:Adaptation, Physiological; D000328:Adult; D018475:Head-Down Tilt / Q000009:adverse effects / Q000502:physiology; D006801:Humans; D018476:Hypokinesia / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D012039:Regional Blood Flow; D013577:Syndrome; D013997:Time Factors; D014463:Ultrasonography; D018474:Weightlessness Simulation / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data