title: Variation of 17 RFLP markers on chromosome 13 in southeastern Spain.
abstract: The allele frequency distribution of 17 nuclear DNA restriction polymorphisms at 15 loci on chromosome 13 was examined in a sample of 70 unrelated autochthonous individuals from La Alpujarra rural mountainous region in Southeastern Spain. The markers typed, 14 associated with anonymous segments and three located on coding regions, constitute a subset from the battery of the nuclear RFLPs previously proposed for population studies (Bowcock et al. 1991). In our sample no Hardy-Weinberg equilibrium deviations were present and the average heterozygosity over all loci was 0.367 +/- 0.031. The significant differences for five markers observed between our sample and a Spanish Basque group underline the usefulness of this kind of DNA markers for the analysis of populations relationships even at the continental level.
authors.affiliation: Departamento de Biologia, Unidad de Antropologia, Facultad de Biologia, Universidad Complutense, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Santander
authors.forename: F
authors.initials: F
authors.lastname: Luna
authors.forename: P
authors.initials: P
authors.lastname: Moral
mesh_terms: D000328:Adult; D000483:Alleles; D002882:Chromosomes, Human, Pair 13; D003241:Consanguinity; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D012424:Rural Population
chemical_list: D005819:Genetic Markers