title: Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls.
abstract: OBJECTIVE
  To assess the status of lipidsoluble antioxidants (carotenoids, tocopherols, ubiquinone), retinol and their correlation with TRAP (total radical-trapping antioxidant potential) in patients with Crohn's disease.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  Clinic of Internal Medicine IV/Department of Gastroenterology and Hepatology, University of Vienna Medical School.
  
  
  METHODS
  Plasma antioxidant concentrations were determined in patients with Crohn's disease (n = 24) to evaluate the antioxidant capacity compared to healthy controls (n = 33). Additionally, plasma TRAP (total radical-trapping antioxidant potential) was measured in 13 patients and 22 controls.
  
  
  RESULTS
  All investigated carotenoids (alpha-carotene, beta-carotene and cryptoxanthin) were significantly decreased in patients with Crohn's disease (10.2 +/- 9.3, 16.2 +/- 12.4 and 7.8 +/- 5.5 microg/dl) compared to controls (13.3 +/- 5.1, 34.7 +/- 18.8 and 48.5 +/- 38.4 microg/dl respectively), whereas gamma-tocopherol and ubiquinone were significantly elevated in patients (0.14 +/- 0.07 microg/dl and 82.3 +/- 41.5 microg/dl, controls: 0.09 +/- 0.04 microg/dl and 60.8 +/- 30.0 microg/dl, respectively). Retinol and alpha-tocopherol did not significantly differ from controls. The total radical-trapping antioxidant potential (TRAP) was significantly lower in patients (1.11 +/- 0.28 micromol/l) compared to controls (1.34 +/- 0.26 micromol/l). Antioxidants were neither related to duration or severity of disease nor to disease activity.
  
  
  CONCLUSIONS
  In patients with Crohn's disease several plasma antioxidant parameters are altered and the total radical-trapping antioxidant potential is decreased.
authors.affiliation: Institute of Nutritional Sciences, University of Vienna, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Genser
authors.forename: M H
authors.initials: MH
authors.lastname: Kang
authors.forename: H
authors.initials: H
authors.lastname: Vogelsang
authors.forename: I
authors.initials: I
authors.lastname: Elmadfa
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002338:Carotenoids / Q000097:blood*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000097:blood* / Q000145:classification; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D012907:Smoking / Q000378:metabolism; D012995:Solubility; D014451:Ubiquinone / Q000097:blood; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D014451:Ubiquinone; D014810:Vitamin E; D002338:Carotenoids