title: Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities.
abstract: Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis.
authors.affiliation: The NEPI Foundation, Medical Research Centre, Malmö University Hospital, Sweden. gunnar.lindberg@nepi.net
authors.forename: G
authors.initials: G
authors.lastname: Lindberg
authors.forename: L
authors.initials: L
authors.lastname: Råstam
authors.forename: P
authors.initials: P
authors.lastname: Nilsson-Ehle
authors.forename: A
authors.initials: A
authors.lastname: Lundblad
authors.forename: J
authors.initials: J
authors.lastname: Ranstam
authors.forename: A R
authors.initials: AR
authors.lastname: Folsom
authors.forename: G L
authors.initials: GL
authors.lastname: Burke
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D012795:Sialoglycoproteins / Q000097:blood*
chemical_list: D015415:Biomarkers; D012795:Sialoglycoproteins; D019158:N-Acetylneuraminic Acid