title: Synthesis of piperazine derivatives and evaluation of their antihistamine and antibradykinin effects.
abstract: Piperazine derivatives were prepared as histamine antagonists. Some of the synthesized compounds showed dual antagonistic activity against bradykinin as well as histamine.
authors.affiliation: School of Pharmacy, Ewha Womans University, Seoul, Korea.
authors.forename: H Y
authors.initials: HY
authors.lastname: Choo
authors.forename: B J
authors.initials: BJ
authors.lastname: Chung
authors.forename: S H
authors.initials: SH
authors.lastname: Chung
mesh_terms: D000818:Animals; D065168:Bradykinin Receptor Antagonists; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats
chemical_list: D065168:Bradykinin Receptor Antagonists; D006634:Histamine H1 Antagonists; D010879:Piperazines