title: Comparison of bednets impregnated with different pyrethroids for their impact on mosquitoes and on re-infection with malaria after clearance of pre-existing infections with chlorproguanil-dapsone.
abstract: Comparisons of bednets treated either with alphacypermethrin or lambdacyhalothrin showed similar effectiveness by various entomological criteria. Lambdacyhalothrin was associated with significantly more reports of nasal irritation than alphacypermethrin. The 2 net treatments were equally effective in reducing incidence of new malaria infections and the treated nets were much more effective than untreated nets. These measurements were made after clearing existing infections with chlorproguanil-dapsone. This drug combination was more than 99% effective in clearing infections 1 week after treatment and a study of children taken to an altitude with no malaria transmission showed that there were very few recrudescences.
authors.affiliation: London School of Hygiene and Tropical Medicine, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Maxwell
authors.forename: J
authors.initials: J
authors.lastname: Myamba
authors.forename: K J
authors.initials: KJ
authors.lastname: Njunwa
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: C F
authors.initials: CF
authors.lastname: Curtis
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003622:Dapsone / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007223:Infant; D007306:Insecticides; D008288:Malaria / Q000517:prevention & control*; D009032:Mosquito Control / Q000379:methods*; D002727:Proguanil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011722:Pyrethrins; D012008:Recurrence; D013636:Tanzania
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D007306:Insecticides; D011722:Pyrethrins; C007030:chlorproguanil; D003622:Dapsone; D002727:Proguanil