title: Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes.
abstract: The effect of growth phase on expression of virulence-associated factors was studied by Northern hybridization in an M1T1 clinical isolate of Streptococcus pyogenes. Expression of M protein, C5a peptidase, and capsule was maximal in the exponential phase of growth, while streptococcal pyrogenic exotoxins A and B and mitogenic factor were maximally expressed in later phases of growth.
authors.affiliation: Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Unnikrishnan
authors.forename: J
authors.initials: J
authors.lastname: Cohen
authors.forename: S
authors.initials: S
authors.lastname: Sriskandan
mesh_terms: D001426:Bacterial Proteins; D003546:Cysteine Endopeptidases / Q000235:genetics; D006801:Humans; D012333:RNA, Messenger / Q000032:analysis; D013297:Streptococcus pyogenes / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D012333:RNA, Messenger; D003546:Cysteine Endopeptidases; C042477:streptopain