title: Substituted amylose as a matrix for sustained drug release.
abstract: OBJECTIVE
  Amylose derivatives form an important group of polymers, and many of them can be used as drug sustained-release systems.
  
  
  METHODS
  Substituted amylose can be prepared in a 1-step reaction with substituent(s) in a basic medium. The substituents can be represented as (A-R), where (A) serves an epoxy, halide or suitable organic or inorganic function reacting with hydroxyl groups located on the amylose chain, and (R) is an organic radical.
  
  
  RESULTS
  The present work shows the synthesis of different polymers and the effect of different (A) and/or (R) and their different degrees of substitution (n) on the sustained drug release from matrix tablets prepared by direct compression.
  
  
  CONCLUSIONS
  SA polymers are interesting excipients for the preparation of controlled drug release tablets.
authors.affiliation: Faculté de Pharmacie, Université de Montréal, Québec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Chebli
authors.forename: I
authors.initials: I
authors.lastname: Moussa
authors.forename: S
authors.initials: S
authors.lastname: Buczkowski
authors.forename: L
authors.initials: L
authors.lastname: Cartilier
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D000473:Alkanes / Q000494:pharmacology; D000688:Amylose / Q000737:chemistry / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology; D002073:Butanes / Q000494:pharmacology; D002273:Carcinogens / Q000737:chemistry / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D016503:Drug Delivery Systems / Q000379:methods*; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology; D006900:Hydroxylation; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D013607:Tablets / Q000494:pharmacology; D014867:Water / Q000737:chemistry
chemical_list: D000473:Alkanes; D018712:Analgesics, Non-Narcotic; D002073:Butanes; D002273:Carcinogens; D003692:Delayed-Action Preparations; D004852:Epoxy Compounds; D011108:Polymers; D020005:Propanols; D013607:Tablets; D014867:Water; C007548:n-dodecane; D000082:Acetaminophen; D000688:Amylose; C004312:glycidol; C006854:butyl chloride