title: [An experimental validation of the use of levomycetin preparations for the treatment of burns infected with Pseudomonas aeruginosa].
abstract: Application of 1% of chloramphenicol (gel and cream) for local treatment of Pseudomonas aeruginosa burn infection has been studied in experiment. In vivo, both medical forms show pronounced therapeutic effect, they promote elimination of P. aeruginosa from wounds and decrease inflammation. In noninfected thermal trauma in laboratory animals application of gel and cream of chloramphenicol reduces transition from the phase of inflammation to the phase of reparation by 3-8 days and prevents infection of the burn wound by conditionally pathogenic microflora.
authors.affiliation: Kharkov State Medical University, Ukraine.
authors.forename: V L
authors.initials: VL
authors.lastname: Tkachenko
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Tsyganenko
authors.forename: N A
authors.initials: NA
authors.lastname: Liapunov
authors.forename: E P
authors.initials: EP
authors.lastname: Bezuglaia
authors.forename: V V
authors.initials: VV
authors.lastname: Minukhin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002056:Burns / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D002701:Chloramphenicol / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005782:Gels; D051379:Mice; D008808:Mice, Inbred CBA; D009824:Ointments; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D009824:Ointments; D002701:Chloramphenicol