title: Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo.
abstract: Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF(70-80)) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden.
authors.affiliation: Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales 2042, South Australia, Australia.
authors.forename: D R
authors.initials: DR
authors.lastname: Roach
authors.forename: H
authors.initials: H
authors.lastname: Briscoe
authors.forename: K
authors.initials: K
authors.lastname: Baumgart
authors.forename: D A
authors.initials: DA
authors.lastname: Rathjen
authors.forename: W J
authors.initials: WJ
authors.lastname: Britton
mesh_terms: D000818:Animals; D005260:Female; D006099:Granuloma / Q000382:microbiology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000187:drug effects*; D010446:Peptide Fragments / Q000627:therapeutic use*; D014376:Tuberculosis / Q000382:microbiology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
chemical_list: D010446:Peptide Fragments; D014409:Tumor Necrosis Factor-alpha