Degeneration of rabbit sensory neurons induced by passive transfer of anti-GD1b antiserum.
Systemic infusion of high-titer anti-GD1b antiserum to two rabbits pre-inoculated with keyhole limpet hemocyanin and Freund's complete adjuvant was performed. The two rabbits had low-titer anti-GD1b antibody in sera. Although no apparent clinical signs were observed, pathological examinations showed vacuolar degeneration with macrophage infiltration in a few axons in the dorsal columns of the spinal cords from the two rabbits. No such pathological changes were observed in the other two pre-inoculated rabbits infused with normal rabbit sera. Anti-GD1b antibody therefore may cause degeneration in rabbit sensory neurons with central axons extending to the dorsal column.
Kusunoki
S
S
Department of Neurology, School of Medicine, University of Tokyo, Japan. kusunoki-tky@umin.ac.jp
Hitoshi
S
S
Kaida
K
K
Murayama
S
S
Kanazawa
I
I
D000818:Animals; D001259:Ataxia / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000276:immunology*; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D008264:Macrophages / Q000473:pathology / Q000502:physiology; D009410:Nerve Degeneration / Q000473:pathology*; D009475:Neurons, Afferent / Q000473:pathology* / Q000502:physiology; D011817:Rabbits; D014617:Vacuoles / Q000502:physiology
D005732:Gangliosides; D007074:Immunoglobulin G; C033851:ganglioside, GD1b