Auditory brainstem responses, electrocochleograms, and cochlear microphonics in the myelin deficient mutant hamster 'bt'.
Electrophysiological studies of the auditory pathway were performed on the mutant hamster 'bt' which is known to have myelin deficiencies in the central nervous system. Auditory brainstem responses (ABRs), electrocochleograms (EcochGs), and cochlear microphonics (CMs) were recorded. ABRs in 'bt' demonstrated markedly transformed waveforms with significantly prolonged latencies. EcochG in 'bt' showed significantly prolonged N1 latencies of the compound action potentials (CAPs) while 'bt' showed normal CMs. The myelin deficient mutant hamster 'bt' may have myelin deficiencies not only in the brainstem auditory pathway but also in the cochlear nerve.
Naito
R
R
Department of Otolaryngology, University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo, Japan. rex-tky@umin.ac.jp
Murofushi
T
T
Mizutani
M
M
Kaga
K
K
D000818:Animals; D003051:Cochlea / Q000502:physiology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology*; D006224:Cricetinae; D004594:Electrophysiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D008647:Mesocricetus / Q000235:genetics*; D009154:Mutation / Q000502:physiology*; D009186:Myelin Sheath / Q000235:genetics*