title: Effect of silane treatment and different resin compositions on biological properties of bioactive bone cement containing apatite-wollastonite glass ceramic powder.
abstract: In methylmethacrylate (MMA)-based cements containing bioactive particles, polymethylmetacrylate (PMMA) is known to suppress the bioactivity of Bioglass(R) and apatite-wollastonite glass ceramic (AW-GC). Little is known about the effect of different silane treatment methods on the bioactivity of AW-GC. MMA-based cement plates containing dry silanated AW-GC particles and PMMA particles of different molecular weights (12,000-900,000) were immersed in simulated body fluid (SBF). Cements containing PMMA particles of high molecular weight formed an apatite layer on the surface after 24 h. Using PMMA particles with a molecular weight of 60,000 and AW-GC particles silanated with different methods (dry method vs. slurry method), cement plates were made and immersed in SBF. Only cement plates containing dry silanated AW-GC particles showed apatite formation in SBF after 3 days. In vivo implantation in rat tibias of MMA-based cement containing dry silanated AW-GC particles and PMMA particles (molecular weight 900,000) demonstrated an affinity index of 32.1 +/- 15.8% after 8 weeks of implantation compared to 89.4 +/- 10.7% achieved by bisphenol-A-glycidyl methacrylate based cement containing the same bioactive powder. By using a dry method of silane treatment and high molecular weight PMMA particles, the bioactivity of cement based on MMA monomer was achieved; but further effort is needed to improve the mechanical properties of the composite.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto University, 54 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto 606-8507, Japan.
authors.forename: W F
authors.initials: WF
authors.lastname: Mousa
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kitamura
authors.forename: I A
authors.initials: IA
authors.lastname: Zeineldin
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids; D001843:Bone Cements / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D008297:Male; D020366:Methylmethacrylate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012117:Resins, Synthetic / Q000737:chemistry*; D012821:Silanes; D012824:Silicic Acid / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013977:Tibia
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D012117:Resins, Synthetic; D012821:Silanes; C077777:apatite-wollastonite-containing glass ceramic; D012824:Silicic Acid; D020366:Methylmethacrylate; D019904:Polymethyl Methacrylate