[Successful pregnancy after liver transplantation].
Two women aged 32 and 30 years became pregnant following orthotopic liver transplantation. The time intervals between transplantation and conception were 9 years and 9 months, respectively. Both women had immunosuppressive prophylaxis. The course of both pregnancies was uneventful; there were no signs or symptoms of graft rejection. At term, both women were delivered vaginally of female infants, weighing 2510 g (2.3rd-5th percentile) and 3200 g (50th-75th percentile), respectively. The second woman had a normal postpartum period while the first one needed blood transfusion for anaemia due to postpartum haemorrhage. From the literature to date it is concluded that apart from an increased likelihood of opportunistic infections, hypertension, diabetes mellitus, osteoporosis, impaired renal function and foetal growth restriction the outcome of pregnancy in women after a liver transplantation is generally favourable. However, the possible long-term effects of medical treatment on maternal and infant health are unknown.
Wildschut
H I
HI
Academisch Ziekenhuis Rotterdam-Dijkzigt.
Metselaar
H J
HJ
Tilanus
H W
HW
D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007231:Infant, Newborn; D016031:Liver Transplantation / Q000009:adverse effects*; D006473:Postpartum Hemorrhage / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000517:prevention & control; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk / Q000187:drug effects*
D007166:Immunosuppressive Agents