Conservation and divergence of axon guidance mechanisms.
Analysis of axon guidance mechanisms in vertebrates, Caenorhabditis elegans, and Drosophila melanogaster has led to the identification of several signaling pathways, many of which are strikingly conserved in function. Recent studies indicate that several axon guidance mechanisms are highly conserved in all animals, whereas others, though still conserved in a general sense, show strong evolutionary divergence at a detailed mechanistic level.
Chisholm
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Sinsheimer Laboratories Department of Biology University of California Santa Cruz, California 96054, USA. chisholm@biology.ucsc.edu
Tessier-Lavigne
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D000818:Animals; D001369:Axons / Q000502:physiology*; D005075:Biological Evolution; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D017027:Protein Tyrosine Phosphatases