title: Effect of sodium cloprostenol and flunixin meglumine on luteolysis and the timing of birth in bitches.
abstract: At birth, the physiological role of prostaglandins in bitches is unclear. Bitches were treated before parturition with either saline, the prostaglandin analogue, sodium cloprostenol, or the prostaglandin synthetase inhibitor, flunixin meglumine. The animals were examined regularly to determine the onset of parturition and a series of blood samples were taken to define the hormonal profiles before, during and after birth. Animals treated with cloprostenol whelped earlier than did controls. In addition, the prostaglandin F2 alpha metabolite surge and decrease in plasma progesterone concentration and rectal temperature were earlier than in controls. Flunixin meglumine disrupted the normal 13,14-dihydro-15-keto prostaglandin F2 alpha profile but did not abolish prostaglandin synthesis completely or delay the onset of labour in treated animals. This study confirms that prostaglandins induce luteolysis and the onset of labour in the bitch. However, the partial inhibition of prostaglandin synthesis does not prevent parturition.
authors.affiliation: Department of Zoology, University of Melbourne, Victoria, Australia.
authors.forename: B J
authors.initials: BJ
authors.lastname: Williams
authors.forename: J R
authors.initials: JR
authors.lastname: Watts
authors.forename: P J
authors.initials: PJ
authors.lastname: Wright
authors.forename: G
authors.initials: G
authors.lastname: Shaw
authors.forename: M B
authors.initials: MB
authors.lastname: Renfree
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D019540:Area Under Curve; D001724:Birth Weight; D001831:Body Temperature / Q000187:drug effects; D003002:Clonixin / Q000031:analogs & derivatives / Q000494:pharmacology; D003008:Cloprostenol / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D004326:Drinking / Q000187:drug effects; D005260:Female; D007745:Labor Onset / Q000187:drug effects*; D003341:Luteolysis / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D011465:Prostaglandins, Synthetic; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D003008:Cloprostenol; D011374:Progesterone; C014558:flunixin meglumine; D015237:Dinoprost; D003002:Clonixin