P'-extended alpha-ketoamide inhibitors of proteasome.
A series of potent P'-extended alpha-ketoamide inhibitors of chymotrypsin-like activity of proteasome is described.
Chatterjee
S
S
Department of Chemistry, Cephalon Inc., West Chester, PA 19380-4245, USA.
Dunn
D
D
Mallya
S
S
Ator
M A
MA
D001120:Arginine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D003546:Cysteine Endopeptidases / Q000187:drug effects*; D015853:Cysteine Proteinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000187:drug effects*; D046988:Proteasome Endopeptidase Complex; D013329:Structure-Activity Relationship
D015853:Cysteine Proteinase Inhibitors; D009097:Multienzyme Complexes; D001120:Arginine; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex