Influvac: a safe Madin Darby Canine Kidney (MDCK) cell culture-based influenza vaccine.
Influenza vaccine production technology based on large scale cell culture technology has been developed. From the characterization of the continuous cell line MDCK as well as drug safety studies we conclude that this cell line and the cell culture system are suitable for biological production. The Down Stream Process (DSP) of the virus-containing harvest fluids guarantees sufficient inactivation of influenza viruses and adequate removal or inactivation of putative adventitious or endogenous viruses, mycoplasma or bacteria. Our data indicate that the tissue culture-based production technology is feasible.
Brands
R
R
Solvay Pharmaceuticals B.V., Weesp, The Netherlands.
Visser
J
J
Medema
J
J
Palache
A M
AM
van Scharrenburg
G J
GJ
D000818:Animals; D002460:Cell Line / Q000821:virology; D003257:Consumer Product Safety; D004285:Dogs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000254:growth & development / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D014776:Virus Cultivation
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines