title: Risk factors for early filtration failure requiring suture release after primary glaucoma triple procedure with adjunctive mitomycin.
abstract: OBJECTIVE
  Postoperative release of scleral flap closure suture is useful in trabeculectomy combined with cataract surgery. We determined risk factors for early filtration failure requiring suture release during the first month after primary glaucoma triple procedure.
  
  
  METHODS
  The medical records of 71 consecutive patients with primary open-angle glaucoma who underwent a primary glaucoma triple procedure (primary trabeculectomy, phacoemulsification, and posterior chamber intraocular lens implantation) were reviewed. Suture release had been performed in 24 of the patients for early filtration failure with postoperative intraocular pressure greater than the target value during the first postoperative month. The long-term filtration failure was defined according to 2 criteria based on medical dependency and requirement of additional surgical procedure for intraocular pressure control. Cox proportional hazards multivariate analysis was performed to identify independent risk factors.
  
  
  RESULTS
  African American race (P = .02), more than 2 preoperative glaucoma drugs (P = .02), and intraocular pressure greater than 14 mm Hg during the first postoperative week (P = .006) were identified as significant independent risk factors requiring suture release for filtration failure during the first postoperative month. Their significance was further confirmed by Kaplan-Meier survival analysis with Mantel-Cox log-rank test (P = .03, P = .02, and P = .001, respectively).
  
  
  CONCLUSIONS
  African American race, more than 2 preoperative medications, and intraocular pressure greater than 14 mm Hg in the first postoperative week are major independent risk factors for initial filtration failure requiring suture release during the first month after primary glaucoma triple procedure. Presence of the risk factors may warrant a more aggressive antiproliferative regimen and/or earlier suture release.
authors.affiliation: Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Mich 48201-1423, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Morris
authors.forename: M O
authors.initials: MO
authors.lastname: Peracha
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.forename: S C
authors.initials: SC
authors.lastname: Cha
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kim
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D005260:Female; D005902:Glaucoma, Open-Angle / Q000208:ethnology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D008937:Mitomycins / Q000627:therapeutic use*; D015999:Multivariate Analysis; D018918:Phacoemulsification; D011183:Postoperative Complications; D012307:Risk Factors; D012590:Sclera / Q000601:surgery; D013536:Suture Techniques; D014130:Trabeculectomy; D017211:Treatment Failure
chemical_list: D008937:Mitomycins