title: Impact of ranitidine on prognosis after simple closure of perforated duodenal ulcer.
abstract: OBJECTIVE
  This randomized controlled study was carried out to evaluate the role of H2 receptor antagonists after simple closure of perforated duodenal ulcer.
  
  
  METHODS
  A total of 192 patients who underwent simple closure for perforated duodenal ulcer were divided into two groups (A: study group and B: control group). Group A patients were treated with H2 receptor antagonists, while the patients in group B received placebo. Only 174 patients were available for endoscopic follow up.
  
  
  RESULTS
  At the end of 24 weeks, only 6 patients out of 90 (6.6%) in group A as compared to 18 patients out of 84 (21.4%) in group B had persistent symptoms of ulcer disease as well as endoscopically proven ulcer (p < 0.05).
  
  
  CONCLUSIONS
  The results indicate that H2 receptor antagonists have a definite role and endoscopic follow up is mandatory to define those cases who actually need definitive surgery.
authors.affiliation: Dayanand Medical College & Hospital, Ludhiana, Punjab, India.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: R S
authors.initials: RS
authors.lastname: Chhina
authors.forename: A
authors.initials: A
authors.lastname: Ghosh
authors.forename: R
authors.initials: R
authors.lastname: Kaura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000188:drug therapy / Q000601:surgery*; D011184:Postoperative Period; D011379:Prognosis; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D011899:Ranitidine