title: Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex.
abstract: Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Espey
authors.forename: R J
authors.initials: RJ
authors.lastname: Ellis
authors.forename: R K
authors.initials: RK
authors.lastname: Heaton
authors.forename: A S
authors.initials: AS
authors.lastname: Basile
mesh_terms: D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D018698:Glutamic Acid / Q000134:cerebrospinal fluid*; D015497:HIV-1; D006801:Humans; D008297:Male
chemical_list: D018698:Glutamic Acid