Thrombin and trypsin receptors: the same mechanism of signalling on cellular surfaces.
Proteinase-activated receptors (PARs), ubiquitous surface molecules participating on many biological processes have been recently discovered. Specific receptors for thrombin (PAR-1 and PAR-3) and trypsin (PAR-2) are described in this review. They belong to a family of G protein-coupled receptors activated by amino acid sequence of N-terminal part of bound ligand revealed by site-specific proteolysis. PARs participate in tissue growth and differentiation, regeneration and reparation, inflammatory response regulation, malignant transformation, but even in vascular tonus and blood pressure regulation. (Fig. 5, Ref. 35.)
Olejar
T
T
Institute of Biophysics, 1st Medical School, Charles University, Prague. 1159@post.cz
Nouza
K
K
D000818:Animals; D006801:Humans; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D011956:Receptors, Cell Surface / Q000502:physiology*; D018179:Receptors, Thrombin / Q000502:physiology*; D015398:Signal Transduction; D013379:Substrate Specificity
D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin