The role of self-recognition in receptor repertoire development. Members of the Janeway Laboratory.
The role of self-antigen recognition in the development of T and B cells of the adaptive immune system has been studied in several different ways. We have shown that CD4 T cells are selected on self-peptide:self-MHC class II ligands, and in the periphery, they are sustained by contact with the same or similar ligands. We have also observed that B cells are positively selected on unknown and presumed self-ligands. We have used this information to explore autoimmune diseases as well. Finally, we have recently identified the innate immune system as playing a crucial role in regulating expression of costimulatory molecules that are required for induction of adaptive immune responses.
Janeway
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Section of Immunobiology, Yale University School of Medicine, and The Howard Hughes Medical Institute, New Haven, CT 06520-8011, USA. charles.janeway@yale.edu
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*
D001324:Autoantigens; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell