Inappropriate antidiuretic hormone secretion after high-dose thiotepa.
High-dose thiotepa has been successfully included in a variety of conditioning regimens for stem cell transplantation in hematological and solid neoplasms. Toxicity of high-dose thiotepa mainly manifests as profound myeloablation and some degree of liver damage. We report a case of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with primary CNS lymphoma who underwent therapy with high-dose thiotepa.
Sica
S
S
Divisione Ematologia, Istituto di Semeiotica Medica, Università Cattolica Sacro Cuore, Rome, Italy.
Cicconi
S
S
Sorà
F
F
Chiusolo
P
P
Piccirillo
N
N
Laurenti
L
L
La Barbera
E O
EO
Giordano
G
G
Leone
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D013852:Thiotepa / Q000008:administration & dosage / Q000009:adverse effects*; D019172:Transplantation Conditioning / Q000009:adverse effects*
D013852:Thiotepa