Synthesis and in vitro cytotoxicity of 1-azaanthraquinone-3-carboxamides.
Five 1-azaanthraquinone-3-carboxamides were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The most active compound, 7b, exhibited cytotoxic activity comparable to doxorubicin.
Lee
H
H
College of Pharmacy, Chungbuk National University, Cheongju, Korea. medchem@trut.chungbuk.ac.kr
Lee
C W
CW
Yang
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SI
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000880:Anthraquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D002452:Cell Count; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D014407:Tumor Cells, Cultured
D000577:Amides; D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin