title: Avian leukosis virus subgroup J: a rapidly evolving group of oncogenic retroviruses.
abstract: A strain of avian leukosis virus (ALV) belonging to a new envelope subgroup J was isolated in the UK in 1988 from meat-type chickens. The disease caused by the members of this subgroup has since spread very rapidly worldwide and has become one of the major problems facing the broiler meat industry. Molecular characterisation of HPRS -103, the prototype of subgroup J, has shown that it has a structure of a typical ALV with gag, pol and env genes. However the env gene was distinct from that of other ALV s and was closely related to that of novel endogenous retroviral elements designated EAV - HP. As other regions of the genome were closely related to ALV s, it is believed that ALV-J has evolved by recombination with the env sequences of EAV - HP. ALV-J has a tropism for myeloid cells, a feature that may be associated with its ability to induce myeloid leukosis. Recent data show that ALV -J isolates evolve rapidly resulting in sequence changes within the variable regions of the env gene leading to antigenic variation. Eradication programmes established for other subgroups are proving to be effective in eradicating ALV-J from infected flocks.
authors.affiliation: Avian Viral Oncogenesis Group, Division of Immunology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK.
authors.forename: K
authors.initials: K
authors.lastname: Venugopal
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D001354:Avian Leukosis Virus / Q000145:classification / Q000235:genetics / Q000276:immunology; D002645:Chickens; D011201:Poultry Diseases / Q000821:virology