Development of a poly(2-hydroxyethyl methacrylate) orbital implant allowing direct muscle attachment and tissue ingrowth.
OBJECTIVE
To develop a poly(2-hydroxyethyl methacrylate) orbital implant that allows tissue ingrowth and direct muscle attachment to minimize the risk of extrusion and to enhance cosmesis.


METHODS
Assessment of clinical outcomes and histologic findings after implantation of 18 prototype prostheses into rabbits. The implants were not wrapped with other tissues or materials.


RESULTS
One case of infection was observed but there were no extrusions, with up to 21 months follow-up. Biocolonization was confirmed histologically. Good movement was observed when a cosmetic shell was fitted.


CONCLUSIONS
The prototype prosthesis appears promising, with particular advantages being the direct attachment of extraocular muscles, good cosmesis and movement, and a low complication rate in this pilot study.
Hicks
C R
CR
Biomaterials Department, The Lions Eye Institute, Nedlands, Perth, Western Australia, Australia.
Clayton
A B
AB
Vijayasekaran
S
S
Crawford
G J
GJ
Chirila
T V
TV
Constable
I J
IJ
D000818:Animals; D001672:Biocompatible Materials; D005500:Follow-Up Studies; D009801:Oculomotor Muscles / Q000000981:diagnostic imaging / Q000601:surgery*; D009915:Orbit / Q000000981:diagnostic imaging; D020273:Orbital Implants / Q000592:standards*; D010865:Pilot Projects; D011102:Polyhydroxyethyl Methacrylate; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D011817:Rabbits; D014057:Tomography, X-Ray Computed
D001672:Biocompatible Materials; D011102:Polyhydroxyethyl Methacrylate