Allelic exclusion in B and T lymphopoiesis.
The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.
Bergman
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Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, The Hebrew University, Hadassah Medical School, Jerusalem, Israel.
D000483:Alleles; D000818:Animals; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics*; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D006410:Hematopoiesis; D006801:Humans; D008745:Methylation; D051379:Mice; D011948:Receptors, Antigen, T-Cell
D011948:Receptors, Antigen, T-Cell