title: The treatment of hypertriglyceridaemia in menopausal women with transdermal oestradiol therapy.
abstract: The objective of this study was to evaluate the effect of transdermal oestradiol on serum triglycerides in menopausal women with pre-existing mild to moderate hypertriglyceridaemia. Forty-four women, who had had a hysterectomy and who had been maintained on 50 microg unopposed oestradiol for six months, were divided into two groups: those with normal baseline triglyceride concentrations (0.4-2 mmol/L) (n = 34) and those with raised baseline readings (> 2-4 mmol/L) (n = 10). There was a significant reduction in the concentrations of serum triglycerides in both groups [-9.6% (P < 0.001) and -17% (P < 0.001), respectively]. Transdermal oestradiol therapy may be a useful treatment option in menopausal women with pre-existing hypertriglyceridaemia. There is a need to conduct large, prospective, controlled trials using transdermal oestradiol to treat hypertriglyceridaemia in menopausal women.
authors.affiliation: The Menopause Clinic, Bombay, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Bhathena
authors.forename: B S
authors.initials: BS
authors.lastname: Anklesaria
authors.forename: A M
authors.initials: AM
authors.lastname: Ganatra
mesh_terms: D000279:Administration, Cutaneous; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D007044:Hysterectomy; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood
chemical_list: D004958:Estradiol