title: A simple means of increasing muscle size after spinal cord injury: a pilot study.
abstract: This study tested that hypothesis that skeletal muscle within a year of spinal cord injury (SCI) would respond to intermittent high force loading by showing an increase in size. Three males about 46 weeks post clinically complete SCI underwent surface electrical stimulation of their left or right m. quadriceps femoris 2 days per week for 8 weeks to evoke 4 sets of ten isometric or dynamic actions each session. Conditioning increased average cross-sectional area of m. quadriceps femoris, assessed by magnetic resonance imaging, by 20+/-1% (p = 0.0103). This reversed 48 weeks of atrophy such that m. quadriceps femoris 54 weeks after SCI was the same size as when the patients were first studied 6 weeks after injury. The results suggest that skeletal muscle is remarkably responsive to intermittent, high force loading after almost one year of little if any contractile activity.
authors.affiliation: Department of Exercise Science, The University of Georgia, Athens 30602, USA. gdudley@coe.uga.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Dudley
authors.forename: M J
authors.initials: MJ
authors.lastname: Castro
authors.forename: S
authors.initials: S
authors.lastname: Rogers
authors.forename: D F
authors.initials: DF
authors.lastname: Apple
mesh_terms: D000328:Adult; D001284:Atrophy / Q000517:prevention & control; D004599:Electric Stimulation Therapy; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D007866:Leg / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology / Q000502:physiology*; D010865:Pilot Projects; D013119:Spinal Cord Injuries / Q000473:pathology* / Q000628:therapy*; D013997:Time Factors