The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma.
The expression of thymidine phosphorylase (TP) and the density of microvessel in advanced gastric carcinoma were examined by immunohistochemistry to evaluate the significance of TP. The expression of TP was negative in 72 cases, positive in 54. The microvessel density correlated with the expression of TP. In total cases, patients with TP-positive tumours survived longer than those with TP-negative tumours. In patients treated with fluorouracil derivatives (FUs), the expression of TP significantly correlated with favourable prognosis and with unfavourable prognosis in those not treated with FUs. The patients with TP-positive tumours, the prognosis of patients treated with FUs was significantly better than that of those not treated with FUs. In patients with TP-positive tumours, treatment with FUs and lymph node metastasis were independent prognostic factors according to the Cox proportional hazards model. Depth of invasion and lymph node metastasis were independent prognostic factors in patients with TP-negative tumours. The determination of the expression of TP might be useful for predicting the efficacy of post-operative chemotherapy using FUs to prevent recurrence in advanced gastric carcinoma patients who undergo curative gastrectomy.
Saito
H
H
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Tsujitani
S
S
Oka
S
S
Kondo
A
A
Ikeguchi
M
M
Maeta
M
M
Kaibara
N
N
D000230:Adenocarcinoma / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D002196:Capillaries / Q000473:pathology; D003131:Combined Modality Therapy; D004790:Enzyme Induction; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000201:enzymology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000201:enzymology* / Q000235:genetics; D011379:Prognosis; D016016:Proportional Hazards Models; D013274:Stomach Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013939:Thymidine Phosphorylase / Q000096:biosynthesis* / Q000235:genetics; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D013939:Thymidine Phosphorylase; D005472:Fluorouracil