title: Neonatal screening for hearing disorders in infants at risk: incidence, risk factors, and follow-up.
abstract: OBJECTIVE
  To determine the incidence and risk factors for hearing disorders in a selected group of neonates and the feasibility of selective hearing screening.
  
  
  METHODS
  Multicenter prospective trial at five centers in Germany.
  
  
  METHODS
  Enrollment criteria: in addition to previously defined risk factors by the Joint Committee on Infant Hearing (family history of hearing loss, in utero infections, craniofacial anomalies, birth weight <1500 g, critical hyperbilirubinemia, ototoxic medications, bacterial meningitis, postnatal asphyxia, mechanical ventilation >5 days, stigmata, or syndromes associated with hearing loss), the impact of maternal drug abuse, birth weight <10th percentile, persistent pulmonary hypertension, and intracranial hemorrhage more than or equal to grade III or periventricular leukomalacia on infant hearing were evaluated. The screening procedure was performed by automated auditory brainstem response (A-ABR; ALGO 1-plus; Natus Med Inc, San Carlos, CA).
  
  
  METHODS
  univariate analyses of risk factors versus A-ABR results and a multivariate regression analysis were used; additionally, the total test time was recorded.
  
  
  RESULTS
  Seven hundred seventy recordings from 777 infants enrolled consecutively constitute the basis of this analysis. Mean gestational age was 33.8 +/- 4.3 weeks, birth weight 2141 +/- 968 g; 431 infants being male and 339 female; 41 (5.3%) infants exhibited pathologic A-ABR results (16 bilateral and 25 unilateral). Meningitis or sepsis, craniofacial malformations, and familial hearing loss were independent significant risk factors. Median total test time was 25 minutes. Follow-up examinations in 31 infants revealed persistent hearing loss in 18 infants (13 infants sensorineural, 5 from mixed disorders), 7 requiring amplification.
  
  
  CONCLUSIONS
  Hearing screening in high-risk neonates revealed a total of 5% of infants with pathologic A-ABR (bilateral 2%). Significant risk factors were familial hearing loss, bacterial infections, and craniofacial abnormalities. Other perinatal complications did not significantly influence screening results indicating improved perinatal handling in a neonatal population at risk for hearing disorders.
authors.affiliation: Children's Hospital, Medical University, Lübeck, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Witte
authors.forename: A
authors.initials: A
authors.lastname: Hildmann
authors.forename: K H
authors.initials: KH
authors.lastname: Hennecke
authors.forename: K U
authors.initials: KU
authors.lastname: Schunck
authors.forename: K
authors.initials: K
authors.lastname: Maul
authors.forename: U
authors.initials: U
authors.lastname: Franke
authors.forename: H
authors.initials: H
authors.lastname: Fahnenstich
authors.forename: H
authors.initials: H
authors.lastname: Rabe
authors.forename: R
authors.initials: R
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Hartmann
authors.forename: L
authors.initials: L
authors.lastname: Gortner
mesh_terms: D000704:Analysis of Variance; D005260:Female; D005858:Germany / Q000453:epidemiology; D006311:Hearing Disorders / Q000151:congenital* / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015997:Neonatal Screening; D011446:Prospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric