[Features of the radiosensitivity of cells from ataxia-telangiectasia patients].
Cell survival, single and double DNA strand breaks formation and removal, spontaneous and induced chromosome aberrations and sister chromatid exchange (SCE) levels in gamma-irradiated cells of patients with ataxia-telangiectasia (AT) were studied. Except SCE all of the above indexes of AT cells sensitivity, were higher, than in normal human cells, but lower, than it is commonly characteristic of AT cells in literature. A conclusion is that the analysed AT cells belong to the AT-variant form. Possible mechanisms of high radiosensitivity of AT cells, accompanied by radioresistance of DNA replication, are discussed. The authors suppose that the DNA repair defect in AT cells is not primary.
Khomasuridze
M M
MM
Genetical and Ecological Centre, Georgian Ministry of Public Health, Tbilisi.
Spivak
I M
IM
Pleskach
N M
NM
Mikhel'son
V M
VM
D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology*; D002869:Chromosome Aberrations; D004249:DNA Damage; D004261:DNA Replication; D005720:Gamma Rays; D006801:Humans; D011836:Radiation Tolerance; D012854:Sister Chromatid Exchange