A metalloprotease prepares the way.
In the nematode Caenorhabditis elegans gonad shape and size is determined by the migration of a leader cell, which is at the tip of the growing gonad arm. A metalloprotease secreted by the leader cell has recently been found to play an essential role in this process, preparing the way ahead for the cell's migration.
Moerman
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Department of Zoology 6270 University Boulevard University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4,. moerman@zoology.ubc.ca
D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; D000818:Animals; D001485:Basement Membrane; D017173:Caenorhabditis elegans / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D029742:Caenorhabditis elegans Proteins; D002417:Cattle; D019070:Cell Lineage; D002465:Cell Movement / Q000502:physiology*; D019483:Disintegrins / Q000235:genetics; D012734:Disorders of Sex Development; D054278:Embryonal Carcinoma Stem Cells; D005109:Extracellular Matrix / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D017930:Genes, Reporter; D006066:Gonads / Q000166:cytology / Q000254:growth & development; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology*; D007814:Larva; D020778:Matrix Metalloproteinase 2 / Q000502:physiology; D008666:Metalloendopeptidases / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology*; D005810:Multigene Family; D009124:Muscle Proteins / Q000502:physiology; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000166:cytology; D010446:Peptide Fragments / Q000235:genetics; D011347:Procollagen / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013045:Species Specificity
D029742:Caenorhabditis elegans Proteins; D019483:Disintegrins; D016326:Extracellular Matrix Proteins; D015801:Helminth Proteins; D009124:Muscle Proteins; D010446:Peptide Fragments; D011347:Procollagen; D011993:Recombinant Fusion Proteins; C047202:procollagen Type I N-terminal peptide; D051722:ADAM Proteins; D000071097:ADAMTS1 Protein; C486323:Adamts1 protein, mouse; C119674:GON-1 protein, C elegans; D008666:Metalloendopeptidases; D020778:Matrix Metalloproteinase 2