Cytokine-induced viral purging--role in viral pathogenesis.
The control of viral infections was previously thought to rely exclusive ly on the antigen-specific destruction of infected cells by the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine- dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.
Guidotti
L G
LG
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. guidotti@scripps.edu
Chisari
F V
FV
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology; D014780:Viruses / Q000276:immunology*
D016207:Cytokines