Low-density lipoprotein receptor-related protein (LRP) gene 766T polymorphism and Parkinson's disease.
The C766T polymorphism in exon 3 of the low-density lipoprotein receptor-related protein (LRP) gene is underrepresented in Alzheimer's disease (AD) compared with normal subjects. We examined this polymorphism in 186 patients with Parkinson's disease (PD) and 187 age-matched normal Chinese subjects in addition to 227 newborns representing the general population. The fraction of individuals with 766T was 12.8% in normal subjects and 11.3% in patients with PD, not a significant difference (p = 0.77). The odds ratio was 0.86 with a 95% confidence interval of 0.44-1.69, thus the LRP C766T polymorphism does not play a major role in risk for PD, although the possibility cannot be excluded that it plays a minor role or is a significant risk factor in other ethnic groups.
Baum
L
L
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Shatin, NT, China.
Dong
Z Y
ZY
Ng
H K
HK
Law
L K
LK
Woo
J
J
Pang
C P
CP
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D005838:Genotype; D006723:Hong Kong; D006801:Humans; D007231:Infant, Newborn; D008077:Lipoproteins, LDL / Q000235:genetics*; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D008077:Lipoproteins, LDL