title: Nodular Pneumocystis carinii pneumonia in SIV-infected macaques.
abstract: Pneumocystis carinii (PC) pneumonia is a frequent manifestation of the acquired immunodeficiency syndrome (AIDS) in humans and macaques. An unusual nodular type of PC pneumonia was observed in two simian immunodeficiency virus (SIV)-inoculated rhesus macaques (Macaca mulatta). These animals developed clinical signs of simian AIDS, including anorexia, weight loss, dyspnea, and collapse. Grossly, both animals had multifocal tan-white nodules 1-10 mm in diameter scattered throughout the lungs. One animal had similar nodules involving the diaphragm and thoracic wall. The lungs were characterized by severe PC pneumonia with numerous large nodules consisting of foamy material that compressed adjacent tissue. The nodules had central areas of necrosis and lysis of alveolar septa. Varying degrees of necrotizing vasculitis were observed in areas of nodular PC pneumonia. The presence of PC in intra-alveolar spaces and nodular lesions was confirmed by immunohistochemistry. No evidence of other agents, including viral inclusions, bacteria, fungi, and lung mites, was detected. The animal with the most severe nodular PC pneumonia had vascular involvement with extrapulmonary spread to the diaphragm, thoracic wall, and regional lymph nodes. This unusual type of nodular PC pneumonia has been rarely seen in human AIDS patients.
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: M A
authors.initials: MA
authors.lastname: Simon
authors.forename: F D
authors.initials: FD
authors.lastname: Doddy
authors.forename: K G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: D
authors.initials: D
authors.lastname: Pauley
authors.forename: A A
authors.initials: AA
authors.lastname: Lackner
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D017809:Fatal Outcome; D007150:Immunohistochemistry; D017403:In Situ Hybridization / Q000662:veterinary; D008168:Lung / Q000473:pathology; D008253:Macaca mulatta; D008297:Male; D011010:Pneumocystis / Q000472:pathogenicity*; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000662:veterinary*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*
chemical_list: D000911:Antibodies, Monoclonal