title: The dielectric properties of neutron irradiated snake venom and its pathological impact.
abstract: The changes in the dielectric properties of a saline solution of Cerastes cerastes snake venom after irradiation with low-level doses of fast neutrons from a Cf-252 source, were investigated. The pathological changes in the internal organs such as liver, kidney spleen, lung and heart of the rats injected with unirradiated and irradiated venom were also studied. The changes in the molecular structure of a diluted saline solution of snake venom were measured through dielectric relaxation studies in the frequency range 0.1-10 MHz at 4 +/- 0.5 degrees C. The absorption spectra of the venom solution were measured in the wavelength range 200 to 600 nm. The results indicated remarkable changes in the molecular radii, shape, relaxation time and dielectric increment of the venom molecules as a result of irradiation. Also, the intensities of the absorption bands of the venom solution decreased as a result of the irradiation process. Furthermore, the pathological examination results indicated that the toxicity of the irradiated venom decreased as compared with that of unirradiated venom, hence increasing the chance of repair of the affected organs.
authors.affiliation: Physics Department, Faculty of Science, Zagazig University, Egypt.
authors.forename: M S
authors.initials: MS
authors.lastname: Hanafy
authors.forename: N A
authors.initials: NA
authors.lastname: Rahmy
authors.forename: M M
authors.initials: MM
authors.lastname: Abd El-Khalek
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D015233:Models, Statistical; D015394:Molecular Structure; D009206:Myocardium / Q000473:pathology; D009502:Neutrons; D011839:Radiation, Ionizing; D051381:Rats; D012910:Snake Venoms / Q000737:chemistry / Q000493:pharmacokinetics / Q000528:radiation effects* / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014783:Viscosity
chemical_list: D012910:Snake Venoms