Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.
Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.
Greenlee
M L
ML
Department of Medicinal Chemistry, Merck Research Laboratorie, Rahway, NJ 07065, USA.
Laub
J B
JB
Balkovec
J M
JM
Hammond
M L
ML
Hammond
G G
GG
Pompliano
D L
DL
Epstein-Toney
J H
JH
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004952:Esters; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D065093:beta-Lactamase Inhibitors
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D004952:Esters; D013438:Sulfhydryl Compounds; D065093:beta-Lactamase Inhibitors