title: MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy.
abstract: The authors used serial gradient-echo MRIs to detect new small hemorrhages in patients with previous lobar hemorrhage. Of 24 lobar hemorrhage patients (17 diagnosed with probable and 7 with possible amyloid angiopathy) who prospectively underwent repeat MRI 1.5 years after initial study, 9 (38%) demonstrated additional hemorrhages at follow-up. Interrater agreement was high. New hemorrhages were more frequent in patients with probable amyloid angiopathy (8 of 17, 47%) with more hemorrhages at baseline (p < 0.01). These results suggest a role for gradient-echo MRI in assessing disease progression in amyloid angiopathy.
authors.affiliation: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Greenberg
authors.forename: H C
authors.initials: HC
authors.lastname: O'Donnell
authors.forename: P W
authors.initials: PW
authors.lastname: Schaefer
authors.forename: E
authors.initials: E
authors.lastname: Kraft
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011446:Prospective Studies