Stability of cefepime in peritoneal dialysis solution.
OBJECTIVE
To determine the stability of cefepime in peritoneal dialysis solution.


METHODS
Cefepime HCl was added to premade bags of Delflex peritoneal dialysis solution with 1.5% dextrose to produce a cefepime concentration of approximately 100 microg/mL. Peritoneal dialysis solution bags were stored at 4, 25, and 37 degrees C to simulate refrigeration, room temperature, and body temperature, respectively. Samples were drawn at scheduled times up to 336, 168, and 48 hours, respectively, after the addition of cefepime HCl. Cefepime concentrations were measured by HPLC.


METHODS
This study was performed at a university-affiliated tertiary care hospital.


METHODS
If the mean concentration of the samples at a given time and condition was >90% of the initial concentration, cefepime was considered stable at that time and condition.


RESULTS
The mean HPLC results for samples drawn at each time and condition were all >90%.


CONCLUSIONS
Cefepime is stable in peritoneal dialysis solution with dextrose 1.5% for 14 days refrigerated, seven days at room temperature, and 48 hours at 37 degrees C.
Williamson
J C
JC
Department of Pharmacy, University of Virginia Health System, Charlottesville, USA. jcwunc@belsouth.net
Volles
D F
DF
Lynch
P L
PL
Rogers
P D
PD
Haverstick
D M
DM
D000077723:Cefepime; D002511:Cephalosporins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D015314:Dialysis Solutions / Q000737:chemistry*; D004355:Drug Stability; D010530:Peritoneal Dialysis; D013696:Temperature; D013997:Time Factors
D002511:Cephalosporins; D015314:Dialysis Solutions; D000077723:Cefepime