title: The effect of excitotoxic lesions centered on the perirhinal cortex in two versions of the radial arm maze task.
abstract: Rats with bilateral ibotenic acid lesions centered on the perirhinal cortex and sham-operated controls were tested in 2 versions of a spatially guided radial arm maze task. Lesioned rats made significantly more errors and required more sessions to reach criterion relative to controls in the standard radial maze task. When they were tested in a delayed nonmatch to sample version of this task, lesioned rats made more errors during the predelay phase and at both the 30-s and 10-min delays of the postdelay phase. These findings provide further support for the hypothesis that the role of the perirhinal cortex in object recognition memory may include reference to some spatial aspect of the environment.
authors.affiliation: Department of Psychology and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
authors.forename: P
authors.initials: P
authors.lastname: Liu
authors.forename: D K
authors.initials: DK
authors.lastname: Bilkey
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology / Q000601:surgery; D018690:Excitatory Amino Acid Agonists; D006185:Habituation, Psychophysiologic; D007051:Ibotenic Acid; D008297:Male; D018782:Maze Learning; D008845:Microinjections; D009833:Olfactory Pathways / Q000502:physiology* / Q000503:physiopathology / Q000601:surgery; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception; D013687:Telencephalon / Q000502:physiology
chemical_list: D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid