Teicoplanin pharmacokinetics in critically ill paediatric patients.
Twenty-one critically ill children aged between 7 days and 12 years were treated with teicoplanin (three loading dosages of 10 mg/kg at 12 h intervals, followed by a maintenance dosage of 10 mg/kg/day). Serum teicoplanin concentrations were monitored by HPLC. Mean concentrations in plasma 30 min after drug administration were 20 +/- 16.1 mg/L. The volume of distribution was 0.30 L/kg and the terminal half-life was 17.41 h. Only 11% of trough values were >10 mg/L (established as desirable values). In critically ill children a dosage of 10 mg/kg/day does not assure serum trough values >10 mg/L.
Sánchez
A
A
Paediatric Intensive Care Section, Gregorio Marañón University General Hospital, Madrid, Spain.
López-Herce
J
J
Cueto
E
E
Carrillo
A
A
Moral
R
R
D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017334:Teicoplanin / Q000097:blood / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D017334:Teicoplanin