title: Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees.
abstract: A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1beta (MIP-1beta) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1beta. Levels of MIP-1beta and MCP-1 release were differentially regulated during endotoxemia.
authors.affiliation: Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. P.E.Dekkers@AMC.UVA.NL
authors.forename: P E
authors.initials: PE
authors.lastname: Dekkers
authors.forename: M
authors.initials: M
authors.lastname: Levi
authors.forename: S J
authors.initials: SJ
authors.lastname: van Deventer
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000378:metabolism*; D054407:Chemokine CCL4; D019446:Endotoxemia / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity*; D019402:Macrophage Inflammatory Proteins / Q000378:metabolism*; D010215:Papio; D010972:Platelet Activating Factor / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
chemical_list: D018932:Chemokine CCL2; D054407:Chemokine CCL4; D004731:Endotoxins; D019402:Macrophage Inflammatory Proteins; D010972:Platelet Activating Factor; D014409:Tumor Necrosis Factor-alpha