title: Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies.
abstract: A previously reported patient presenting sensory-dominant neuropathy with antiganglioside antibodies, bound preferentially to polysialogangliosides including GD1b, was autopsied. While axonal degeneration was predominant in the sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decreased F-wave conduction velocities and conduction blocks in motor nerves and decreased or absent sensory action potentials in sensory nerves, with distribution of GD1b in nerve tissues such as dorsal root ganglia and paranodal myelin in the ventral and dorsal roots.
authors.affiliation: Department of Neurology, National Shizuoka Hospital, 24-1 Joto-cho, Shizuoka 420-8533, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Obi
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Takatsu
authors.forename: S
authors.initials: S
authors.lastname: Kusunoki
authors.forename: M
authors.initials: M
authors.lastname: Serizawa
authors.forename: K
authors.initials: K
authors.lastname: Mizoguchi
authors.forename: R
authors.initials: R
authors.lastname: Koike
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000032:analysis*; D001369:Axons / Q000648:ultrastructure; D002102:Cadaver; D005727:Ganglia, Spinal / Q000473:pathology; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D012677:Sensation / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology
chemical_list: D000906:Antibodies; D005732:Gangliosides