title: Im-trityl protection of histidine.
abstract: A rational attempt to prepare FmocHis(piTrt)OH regiospecifically gave in fact the well-known tau-trityl isomer, and experiments with model systems indicate that the prospects for access to pi-trityl histidine derivatives, which would be of great value for the racemization-free synthesis of histidine-containing peptides, are poor.
authors.affiliation: The Dyson Perrins Laboratory, University of Oxford, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Harding
authors.forename: J H
authors.initials: JH
authors.lastname: Jones
authors.forename: A N
authors.initials: AN
authors.lastname: Sabirov
authors.forename: V V
authors.initials: VV
authors.lastname: Samukov
mesh_terms: D006639:Histidine / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
chemical_list: D014320:Triphenylmethyl Compounds; D006639:Histidine; C003723:trityl chloride