[Para-aminobenzoic acid--an interferon inducer].
Para-aminobenzoic acid (PABA) was shown to be an early type interferon inductor. PABA (10 micrograms/ml) induced interferon production in vitro in the cells of human peripheral blood and in vivo in albino mice (10 mg/kg). The results of the study suggested that PABA was able to induce production of interferon-alpha/beta in various immunocyte populations. By its interferonogenic activity PABA was comparable with the known interferon inductors. One of the mechanisms of the previously described in vivo antiherpes action of PABA can be attributed to its interferon inducing activity.
Akberova
S I
SI
N.E. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
Tazulakhova
E B
EB
Musaev-Galbinur
P I
PI
Leont'eva
N A
NA
Stroeva
O G
OG
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D004686:Encephalomyocarditis virus / Q000187:drug effects; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D051379:Mice
D000998:Antiviral Agents; D007369:Interferon Inducers; D010129:4-Aminobenzoic Acid