A retrospective study of Creutzfeldt-Jakob disease in Belgium.
Using data from Belgian neuropathological archives, completed with the results of a comprehensive study of available medical records, we found 100 patients who fulfilled diagnostic criteria for probable or definite Creutzfeldt-Jakob d1551isease (CJD). Mean age at death was 63 years. The median disease duration was 9 months. Progressive mental deterioration was present in all cases, whereas signs of cerebellar dysfunction and myoclonus were found in approximately 80% of the patients. In 50% of the population, the EEG revealed characteristic abnormalities. Ninety-six patients suffered from the sporadic type of CJD, while 4 suffered from a hereditary form. In our series, we could find no evidence for the new variant, neither for an iatrogenic cause.
Pals
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Born Bunge Foundation, University of Antwerp, Wilrijk, Belgium.
Van Everbroeck
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B
Sciot
R
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Godfraind
C
C
Robberecht
W
W
Dom
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R
Laterre
C
C
Martin
J J
JJ
Cras
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P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001530:Belgium / Q000453:epidemiology; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies