Tolerance to vascularized organ allografts in large-animal models.
Although studies of tolerance induction in large animals remain limited compared with murine studies, a number of encouraging observations have been recently reported - especially in nonhuman primate models. The development of antibodies or proteins binding to costimulatory molecules and of an immunotoxin that is active on T cells have been particularly important advances leading to expanded opportunities for extending strategies for tolerance induction to large animals.
Kawai
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Massachusetts General Hospital, Room White 510, Department of Surgery, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. kawai@helix.mgh.harvard.edu
Sachs
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Cosimi
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D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD / Q000187:drug effects; D000943:Antigens, Differentiation / Q000187:drug effects; D018122:B7-1 Antigen / Q000187:drug effects; D051940:B7-2 Antigen; D001808:Blood Vessels; D016026:Bone Marrow Transplantation; D060908:CTLA-4 Antigen; D007108:Immune Tolerance; D018796:Immunoconjugates; D008213:Lymphocyte Activation / Q000187:drug effects; D008212:Lymphocyte Depletion; D008562:Membrane Glycoproteins / Q000187:drug effects; D011323:Primates / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects; D014184:Transplantation, Homologous / Q000276:immunology* / Q000379:methods*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D060908:CTLA-4 Antigen; D018796:Immunoconjugates; D008562:Membrane Glycoproteins; D000069594:Abatacept