title: Successful eradication of mucormycosis occurring in a pulmonary allograft.
abstract: The zygomycetes are saprophytic fungi that rarely cause disease in the normal human host. In immunocompromised individuals, these organisms can cause invasive infections, collectively called mucormycosis. Mucormycosis is associated with a high mortality rate, especially in organ transplant recipients. In this report, we describe the first case of successfully treated mucormycosis involving a pulmonary allograft. Treatment consisted of surgical excision of the affected lobe and chest wall and lipid-complex amphotericin B. The lipid complex formulation permitted a prolonged course of therapy that was likely critical to eradication of the infection.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Hunstad
authors.forename: A H
authors.initials: AH
authors.lastname: Cohen
authors.forename: J W
authors.initials: JW
authors.lastname: St Geme
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D005260:Female; D016041:Heart-Lung Transplantation / Q000009:adverse effects*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D009090:Mucorales / Q000302:isolation & purification; D009091:Mucormycosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D011013:Pneumonectomy / Q000379:methods*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B