Cyclosporine A-induced cell cycle arrest and cell death in renal epithelial cells.
We studied the effects of cyclosporine A (CsA) on the proliferation of LLC-PK1 proximal tubule epithelial cells. DNA damage was found to be an early event in CsA nephrotoxicity and could be a sensitive indicator of CsA injury in renal epithelial cells. Cell cycle arrest induced by CsA was coincident with elevated p53 levels. It is possible that trans-activating p21 may mediate the halting of the cell cycle through the CsA-induced accumulation of p53.
Lally
C
C
Department of Pharmacology, University College Dublin, Ireland.
Healy
E
E
Ryan
M P
MP
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology*; D004847:Epithelial Cells / Q000166:cytology* / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology*; D018374:LLC-PK1 Cells / Q000166:cytology / Q000187:drug effects; D013552:Swine
D007166:Immunosuppressive Agents; D016572:Cyclosporine