N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Williams
T M
TM
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA.
Bergman
J M
JM
Brashear
K
K
Breslin
M J
MJ
Dinsmore
C J
CJ
Hutchinson
J H
JH
MacTough
S C
SC
Stump
C A
CA
Wei
D D
DD
Zartman
C B
CB
Bogusky
M J
MJ
Culberson
J C
JC
Buser-Doepner
C
C
Davide
J
J
Greenberg
I B
IB
Hamilton
K A
KA
Koblan
K S
KS
Kohl
N E
NE
Liu
D
D
Lobell
R B
RB
Mosser
S D
SD
O'Neill
T J
TJ
Rands
E
E
Schaber
M D
MD
Huff
J R
JR
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051231:Farnesyltranstransferase; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D007093:Imidazoles; D010879:Piperazines; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase