title: 3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis.
abstract: Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul.
authors.forename: A N
authors.initials: AN
authors.lastname: Pae
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: H Y
authors.initials: HY
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Joo
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: K I
authors.initials: KI
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: H Y
authors.initials: HY
authors.lastname: Koh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010080:Oxazoles