Interferons as a paradigm for cytokine signal transduction.
Characterization of the ability of interferons to induce immediate early genes led to the identification of the signal transducer and activators of transcription (STAT) signaling paradigm, where a single protein transduces signals directly from the receptor to the nucleus. Subsequent studies have determined that all cytokines transduce pivotal signals through at least one of the seven members of this STAT family. Notably, cytokines can be placed in functional subgroups based on the STATs they activate.
Schindler
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C
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. cws4@columbia.edu
Brutsaert
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S
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D007372:Interferons / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000502:physiology
D016207:Cytokines; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D007372:Interferons