[Modification of the repair processes in chemical mutagenesis in Drosophila melanogaster].
The effect of 1,4-dihydroisonicotinic acid derivative (1,4-DHINA), glutapyrone, on the frequency of sex-linked recessive lethals (SLRL), which were induced by ethyl methanesulfonate (EMS) in spermatozoa, was studied in Drosophila males and females under different exposure conditions. This test was used to analyze repair processes in EMS mutagenesis. Glutapyrone manifested the protective effect after precultivation of males at the stage of larvae and females with glutapyrone. This preparation was shown to have no effect on the frequency of EMS-induced mutations under other conditions (precultivation and subsequent cultivation of mature males with glutapyrone). These data confirmed a key role of indirect mechanisms responsible for the effect of the examined antimutagen. Glutapyrone may be assumed to improve the synthesis or functioning of enzymes involved in the repair of O6-ethylguanine. After adaptive treatment of Drosophila with low doses of the mutagen, glutapyrone increased the fertility of parents but did not suppress chemical mutagenesis.
Kuzhir
T D
TD
Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk.
Dalivelia
O V
OV
Savina
N V
NV
D000222:Adaptation, Physiological; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004260:DNA Repair; D004095:Dihydropyridines / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005260:Female; D005804:Genes, Lethal; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis; D013094:Spermatozoa / Q000187:drug effects
D016587:Antimutagenic Agents; D004095:Dihydropyridines; D005971:Glutamates; C086069:glutapyrone; D005020:Ethyl Methanesulfonate