Photosensitivity diseases: cutaneous lupus erythematosus.
Ultraviolet radiation plays an important role in the induction of lesions in many patients with cutaneous lupus. In the photosensitive subset of lupus, subacute cutaneous lupus, the effects of ultraviolet radiation likely act in concert with specific autoantibodies, particularly anti-Ro-related autoantibodies, to produce lesions. Potential effects of ultraviolet radiation on the induction of cutaneous lupus, and the potential interplay of specific autoantibodies with ultraviolet radiation are discussed. The steps involved in the induction of cutaneous lupus lesions by ultraviolet radiation have not been fully elucidated. Recent advances in phototesting and analysis of the genetics of lupus should clarify the events leading to photosensitive cutaneous lupus lesions.
Lee
L A
LA
Department of Medicine, Denver Health Medical Center, Colorado, USA. Lela.Lee@UCHSC.edu
Farris
A D
AD
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens / Q000032:analysis; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000209:etiology* / Q000276:immunology; D013472:Sunlight / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
D001323:Autoantibodies; D001324:Autoantigens