title: Prevalence of coeliac disease in Turner syndrome.
abstract: This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.
authors.affiliation: Department of Paediatrics, University of Lund, University Hospital, Malmö, Sweden.
authors.forename: S A
authors.initials: SA
authors.lastname: Ivarsson
authors.forename: A
authors.initials: A
authors.lastname: Carlsson
authors.forename: A
authors.initials: A
authors.lastname: Bredberg
authors.forename: J
authors.initials: J
authors.lastname: Alm
authors.forename: S
authors.initials: S
authors.lastname: Aronsson
authors.forename: J
authors.initials: J
authors.lastname: Gustafsson
authors.forename: L
authors.initials: L
authors.lastname: Hagenäs
authors.forename: A
authors.initials: A
authors.lastname: Häger
authors.forename: B
authors.initials: B
authors.lastname: Kriström
authors.forename: C
authors.initials: C
authors.lastname: Marcus
authors.forename: C
authors.initials: C
authors.lastname: Moëll
authors.forename: K O
authors.initials: KO
authors.lastname: Nilsson
authors.forename: T
authors.initials: T
authors.lastname: Tuvemo
authors.forename: O
authors.initials: O
authors.lastname: Westphal
authors.forename: K
authors.initials: K
authors.lastname: Albertsson-Wikland
authors.forename: J
authors.initials: J
authors.lastname: Aman
mesh_terms: D000293:Adolescent; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A; D015995:Prevalence; D013548:Sweden / Q000453:epidemiology; D014424:Turner Syndrome / Q000150:complications*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D005903:Gliadin