title: Chemoenzymatic synthesis and antitumor promoting activity of 6'- and 3-esters of 2-O-beta-D-glucosylglycerol.
abstract: Through a simple chemoenzymatic approach 6'- and 3-esters of 2-O-beta-D-glucosylglycerol 1, with short-medium length fatty acid acyl chains, were prepared. The study of their in vitro antitumor promoting effect on Epstein-Barr virus early antigen (EBV-EA) activation, in comparison with that of the 1-esters previously described, confirms the significant activity of such monoacylated glycoglycerolipid analogues and establishes for the glucose series that the 1-substitution and the hexanoyl chain are the proper structural features for the maximum activity.
authors.affiliation: Dipartimento di Chimica e Biochimica Medica, Università di Milano, Italy. diego.colombo@unimi.it
authors.forename: D
authors.initials: D
authors.lastname: Colombo
authors.forename: F
authors.initials: F
authors.lastname: Compostella
authors.forename: F
authors.initials: F
authors.lastname: Ronchetti
authors.forename: A
authors.initials: A
authors.lastname: Scala
authors.forename: L
authors.initials: L
authors.lastname: Toma
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
mesh_terms: D016588:Anticarcinogenic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000956:Antigens, Viral / Q000187:drug effects / Q000276:immunology; D002460:Cell Line; D004952:Esters; D005989:Glycerides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D004952:Esters; D005989:Glycerides; D006027:Glycosides