Lung elastic recoil during breathing at increased lung volume.
During dynamic hyperinflation with induced bronchoconstriction, there is a reduction in lung elastic recoil at constant lung volume (R. Pellegrino, O. Wilson, G. Jenouri, and J. R. Rodarte. J. Appl. Physiol. 81: 964-975, 1996). In the present study, lung elastic recoil at control end inspiration was measured in normal subjects in a volume displacement plethysmograph before and after voluntary increases in mean lung volume, which were achieved by one tidal volume increase in functional residual capacity (FRC) with constant tidal volume and by doubling tidal volume with constant FRC. Lung elastic recoil at control end inspiration was significantly decreased by approximately 10% within four breaths of increasing FRC. When tidal volume was doubled, the decrease in computed lung recoil at control end inspiration was not significant. Because voluntary increases of lung volume should not produce airway closure, we conclude that stress relaxation was responsible for the decrease in lung recoil.
Rodarte
J R
JR
Department of Medicine, Pulmonary Section, Baylor College of Medicine, Houston, Texas 77030, USA. rodarte@bcm.tmc.edu
Noredin
G
G
Miller
C
C
Brusasco
V
V
Pellegrino
R
R
D000328:Adult; D004548:Elasticity; D005652:Functional Residual Capacity; D006801:Humans; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D010991:Plethysmography; D012016:Reference Values; D012143:Respiratory Physiological Phenomena; D013990:Tidal Volume