title: Therapeutic drug use during pregnancy: a comparison in four European countries. OECM Working Group. Occupational Exposures and Congenital Anomalies.
abstract: A drug utilization study was performed using data of the OECM study on Occupational Exposures and Congenital Malformations, which was conducted in six European Registries of Congenital Anomalies (two in France, two in Italy, one in Great Britain, and one in The Netherlands): the mothers were interviewed after delivery for exposures during pregnancy, including use of therapeutic drugs. The analysis of drug use considered only the 1134 control mothers of healthy newborns, and focused on the first trimester of pregnancy: 36.2% of the interviewed mothers used at least one drug (excluding vitamins and minerals) during the first trimester. This rate varied from 22.5% in Glasgow to 50.3% and 44.2% in the French centers. Anti-infectives were the most frequent drugs (12.3% of mothers), then antinauseants (10.6%), and treatments for threatened abortion (5.5%). Important variations between countries were observed, reflecting different medical attitudes towards drug use during pregnancy.
authors.affiliation: INSERM U149 and Paris Registry of Congenital Anomalies, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: De Vigan
authors.forename: H E
authors.initials: HE
authors.lastname: De Walle
authors.forename: S
authors.initials: S
authors.lastname: Cordier
authors.forename: J
authors.initials: J
authors.lastname: Goujard
authors.forename: R
authors.initials: R
authors.lastname: Knill-Jones
authors.forename: S
authors.initials: S
authors.lastname: Aymé
authors.forename: E
authors.initials: E
authors.lastname: Calzolari
authors.forename: F
authors.initials: F
authors.lastname: Bianchi
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D017723:Drug Utilization Review / Q000706:statistics & numerical data*; D005260:Female; D005602:France; D006801:Humans; D007558:Italy; D009426:Netherlands; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012959:Socioeconomic Factors; D006113:United Kingdom