title: Effect of carbogen inhalation on peripheral tissue perfusion and oxygenation in patients suffering from sudden hearing loss.
abstract: The effects of repeated carbogen inhalation on peripheral tissue perfusion and oxygenation were assessed in 5 patients suffering from sudden hearing loss by means of continuously measured subcutaneous tissue oxygen and carbon dioxide tension, transcutaneous oxygen tension, laser Doppler red cell flux, and fingertip temperature. The subcutaneous oxygen tension increased clearly during the carbogen inhalation periods, and also, a smaller increase in subcutaneous carbon dioxide tension was simultaneously noticed. The changes in transcutaneous oxygen tension were even greater and the latency was shorter as compared with the subcutaneous gas tensions. The laser Doppler measurements showed no signs of vasoconstriction during the study. In conclusion, carbogen inhalation increases peripheral tissue oxygenation without microvascular vasoconstriction and with only a minor retention of carbon dioxide.
authors.affiliation: Department of Otorhinolaryngology, Turku University Central Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kallinen
authors.forename: K
authors.initials: K
authors.lastname: Kuttila
authors.forename: K
authors.initials: K
authors.lastname: Aitasalo
authors.forename: R
authors.initials: R
authors.lastname: Grénman
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous / Q000379:methods; D001831:Body Temperature / Q000502:physiology; D002245:Carbon Dioxide / Q000627:therapeutic use*; D003051:Cochlea / Q000098:blood supply*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000628:therapy*; D003639:Hearing Loss, Sudden / Q000628:therapy*; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000627:therapeutic use*; D010101:Oxygen Consumption; D010477:Perfusion; D015424:Reperfusion; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen