[Do cytokines have any value in the patients with chronic blood circulation insufficiency?].
Heart failure is a common and increasing public problem. Neurohormonal activation plays a role in the pathophysiology of heart failure, but is probably also affected by cytokines. We studied 75 patients with heart failure NYHA functional class II and III-IV, who were treated with angiotensin converting enzyme inhibitor (enarenal), diuretics (furosemide) and digoxine. Their mean age was 63.9 years/range 65-86/, left ventricular ejection fraction in the patients NYHA functional class II and III-IV classes was 68.9% and 47.3% respectively; 12 were females. Significant improvements in NYHA classification were shown. The levels plasma TNF-alpha (tumor necrosis factor-alpha) and interleukin-6 (IL-6) were analysed before and after therapy. The authors showed increased plasma levels TNF-alpha and IL-6 in patients with chronic heart failure. After the treatment the plasma IL-6 levels decreased only in the patients III-IV NYHA functional classes, whereas the treatment had no effect on the plasma TNF-alpha levels.
Mazurek
W
W
Katedry i Kliniki Kardiologii AM we Wrocławiu.
Jołda-Mydłowska
B
B
Halawa
B
B
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002908:Chronic Disease; D004070:Digitalis / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000276:immunology*; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal; D010947:Plants, Toxic; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha