title: Pregnancy does not adversely affect renal transplant function.
abstract: Women with functioning transplanted kidneys often become fertile again. Indeed, renal function, endocrine status and libido rapidly improve after renal transplantation, and 1:50 women of childbearing age become pregnant. However, there is concern regarding the haemodynamic changes of pregnancy, which could lead to a decline in graft function (temporary or permanent). We examined obstetric data and renal parameters in 29 patients and 33 pregnancies. Mean serum creatinine and creatinine clearance remained stable throughout pregnancy and 1 year postpartum. However, there was a significant increase in proteinuria from a mean of 0.45 g/24 h around the time of conception to 1.11 g/24 h at delivery (p<0.05). The proteinuria resolved to baseline levels at 3 months postpartum. We highlight certain parameters to be considered before conception to allow a good obstetric outcome and prolong stable renal function: serum creatinine <150 micromol/l, proteinuria <1 g/day, absence of histological evidence of chronic allograft rejection, controlled blood pressure (140/90) and stability of maintenance immunosuppression.
authors.affiliation: Renal Unit and Renal Transplant Unit, Royal Liverpool University Hospital and The Liverpool Womens' Hospital, Liverpool, UK. avcrowe@aol.com.uk
authors.forename: A V
authors.initials: AV
authors.lastname: Crowe
authors.forename: R
authors.initials: R
authors.lastname: Rustom
authors.forename: C
authors.initials: C
authors.lastname: Gradden
authors.forename: R A
authors.initials: RA
authors.lastname: Sells
authors.forename: A
authors.initials: A
authors.lastname: Bakran
authors.forename: J M
authors.initials: JM
authors.lastname: Bone
authors.forename: S
authors.initials: S
authors.lastname: Walkinshaw
authors.forename: G M
authors.initials: GM
authors.lastname: Bell
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000502:physiology*; D011247:Pregnancy / Q000097:blood / Q000502:physiology* / Q000652:urine; D011507:Proteinuria / Q000175:diagnosis
chemical_list: D003404:Creatinine