title: [Clinical features, diagnosis and treatment for trophic, late radiation ulcers and ulcers undergone malignant transformation].
abstract: Clinical and histological examinations of 1562 patients with trophic and advanced radiation ulcers were carried out during 30 years. Malignant transformation of the ulcers has been revealed in 14 of them: sarcoma--in 1, and cancer--in 13. From all the patients with advanced radiation ulcers, malignant transformation was detected in 7.07%, and in cases of ulcers of the other genesis--in 0.81% of cases. Malignant transformation of ulcers of non-radiation genesis occurs on the average after 19 years, and of radiation one--after 3.8 years. Early diagnosis of skin cancer, at the site of the ulceris rather difficult and depends thoroughly on oncological alert and timely morphological examination of various skin areas. A new, rather perspective and relatively simple method of treatment for ulcerative forms of cancer of the skin is photodynamic therapy (PhDT). This method showed to be effective even in those patients who failed conventional methods of treatment (relapses), or had contraindications. PhDT has broaden the armory of the oncologists and oncodermatologists for treatment of complicated forms of cancer of the skin.
authors.forename: P I
authors.initials: PI
authors.lastname: Tostykh
authors.forename: E F
authors.initials: EF
authors.lastname: Stranadko
authors.forename: U M
authors.initials: UM
authors.lastname: Koraboev
authors.forename: V A
authors.initials: VA
authors.lastname: Duvanskiĭ
authors.forename: M R
authors.initials: MR
authors.lastname: Kalinin
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Vatlin
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011832:Radiation Injuries / Q000150:complications*; D012509:Sarcoma / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D017319:Photosensitizing Agents