Association of CCR5 delta32 with reduced risk of asthma.
We report that individuals carrying the CCR5 delta32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.
Hall
I P
IP
Wheatley
A
A
Christie
G
G
McDougall
C
C
Hubbard
R
R
Helms
P J
PJ
D000293:Adolescent; D000483:Alleles; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D015995:Prevalence; D019713:Receptors, CCR5 / Q000235:genetics*; D012606:Scotland / Q000453:epidemiology
D019713:Receptors, CCR5