title: [A comparative study of the hemolytic activity of triterpene polyols of the dammarane series].
abstract: We studied membranotropic effect of dammarane-type triterpenes (isolated from birch leaves) with a variable side chain structure, as well as the number and configuration of OH groups as a function of temperature and pH. Polyols with an acyclic side chain and four OH groups proved to have a higher hemolytic activity as compared to polyols with three or five hydroxyl groups. The triterpenes, with tetrahydrofurane cycle as the side chain, exert a hemolytic effect at a more acidic pH (5.0) and higher temperature (45 degrees C), as compared to the polyols with acyclic side chain. Irrespective of the side chain structure, the compounds with a 24(S) configuration lysed the erythrocytes at lower rate, as compared to the compounds with a 24(R) configuration.
authors.affiliation: Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, Vladivostok, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Prokof'eva
authors.forename: E B
authors.initials: EB
authors.lastname: Shentsova
authors.forename: S I
authors.initials: SI
authors.lastname: Stekhova
authors.forename: M M
authors.initials: MM
authors.lastname: Anisimov
authors.forename: N D
authors.initials: ND
authors.lastname: Pokhilo
authors.forename: N I
authors.initials: NI
authors.lastname: Uvarova
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D013256:Steroids / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013696:Temperature; D014197:Trees; D014315:Triterpenes / Q000494:pharmacology*; D000097669:Dammaranes
chemical_list: D010936:Plant Extracts; D013256:Steroids; D014315:Triterpenes; D000097669:Dammaranes