[The "direct mitogen" lead nitrate causes an intensification in lipid peroxidation and Ito cell activation in the rat liver].
We have used biochemical and immunohistochemical methods to study lipid peroxidation and activation of Ito cells in rat liver after a single administration of lead nitrate, a "direct mitogen". Lead nitrate was shown to injure hepatocytes through an increased lipid peroxidation. Response to the injury included increase in the proliferative activity of parenchymal and sinusoidal liver cells. In addition, activation of Ito cells has been noted, which manifested as increased expression of desmin and increased proliferation. However, no transformation of Ito cells into myofibroblasts has been observed. We discuss the possible role of Ito cell activation in creating conditions for the proliferation of liver parenchymal cells after the injury by lead nitrate.
Gumerova
A A
AA
Kazan Medical University, Tatarstan, Russia.
Valeeva
I Kh
IKh
Kiiasov
A P
AP
D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003893:Desmin / Q000187:drug effects / Q000378:metabolism; D007150:Immunohistochemistry; D007854:Lead / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D009566:Nitrates / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D003893:Desmin; D008934:Mitogens; D009566:Nitrates; D018809:Proliferating Cell Nuclear Antigen; D007854:Lead; C017461:lead nitrate