Knocking out the stress response.
Transgenic animals and knockout mice have been generated with defined defects in various components of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. These models provide valuable and novel insights into the development, crosstalk, organization, and functioning of the stress system.
Bornstein
S
S
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. bornstes@mail.nih.gov
Böttner
A
A
Chrousos
G
G
D000818:Animals; D004195:Disease Models, Animal; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000503:physiopathology; D013312:Stress, Physiological / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology