[The effect of tactivin and levamisole on the development of toxic brain edema-swelling].
Edema-swelling of the brain (ESB) is among the urgent problems of modern medicine. The purpose of the research was the study of the effect of immunotropic agents on formation of the pathologic process. It was demonstrated on a model of toxic ESB that taktivin and levamisole possess antiedemic activity. The effect is dose-dependent and is determined by the structural characteristics of the drugs under study. Unlike taktivin, large doses of levamisole demonstrate synergism with the effect of the edematous factor.
Platonov
I A
IA
Smolensk State Medical Academy, Russia.
Andreeva
T A
TA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001834:Body Water / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D009538:Nicotine; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D013329:Structure-Activity Relationship; D013949:Thymus Extracts / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; D007978:Levamisole; D009538:Nicotine; C036191:T-activin