Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice.
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.
Dieterich
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C
Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland.
Bouzourène
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H
Blum
A L
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Corthésy-Theulaz
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IE
D000818:Animals; D001284:Atrophy; D001428:Bacterial Vaccines / Q000276:immunology*; D002772:Cholera Toxin / Q000276:immunology; D005753:Gastric Mucosa / Q000473:pathology*; D016998:Helicobacter / Q000276:immunology*; D016481:Helicobacter Infections / Q000517:prevention & control*; D018928:Immunity, Mucosal; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000276:immunology; D014510:Urease / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D001428:Bacterial Vaccines; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D002772:Cholera Toxin; D014510:Urease