State-of-the-Art lecture: influence of exercise training on neurogenic control of blood pressure in spontaneously hypertensive rats.
Exercise training plays an important role in the reduction of high blood pressure. In this review, we discuss the effect of distinct intensities of exercise training on the reduction of high blood pressure in spontaneously hypertensive rats (SHR). In addition, we present some hemodynamic mechanisms and associated neural controls by which exercise training attenuates hypertension in SHR. Low-intensity exercise training is more effective in reducing high blood pressure than is high-intensity exercise training in SHR. The decrease in blood pressure is due to resting bradycardia, and in consequence, lower cardiac output. Sympathetic attenuation to the heart is the major explanation for the resting bradycardia. Recovery of the sensitivity of baroreflex control of heart rate, which is usually impaired in SHR, is an important neurogenic component involved in the benefits elicited by exercise training.
Krieger
E M
EM
Hypertension Unit, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. edkrieger@incor4.incor.usp.br
Brum
P C
PC
Negrão
C E
CE
D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D013564:Sympathetic Nervous System / Q000503:physiopathology*