Localization of transforming growth factors beta1 and beta2 and epidermal growth factor in IgA nephropathy.
OBJECTIVE
The localization of transforming growth factor (TGF)-beta1. TGF-beta2 and epidermal growth factor (EGF) was investigated in IgA nephropathy, and was compared with the severity of histological damage (including tubulointerstitial lesions).


METHODS
The enzyme antibody method was used to stain paraffin-embedded sections of renal tissue from 42 patients with IgA nephropathy (19 males and 23 females).


RESULTS
There was a significant correlation between glomerular positivity for TGF-beta1 and TGF-beta2 and the severity of histological damage. There was also a significant correlation between positivity for TGF-beta1 and TGF-beta2 in the tubular epithelium and tubulointerstitial lesions. In contrast, there was no relationship between glomerular positivity for EGF and histological damage, although there was a significant correlation between positivity for EGF in the tubular epithelium and tubulointerstitial lesions.


CONCLUSIONS
These findings suggest that TGF-beta1 and TGF-beta2 may be important in the progression of IgA nephropathy, and that the distribution of EGF may also be a useful marker for the progression of renal damage, including tubulointerstitial lesions.
Taniguchi
Y
Y
Second Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima City, Japan.
Yorioka
N
N
Masaki
T
T
Asakimori
Y
Y
Yamashita
K
K
Yamakido
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D004815:Epidermal Growth Factor / Q000096:biosynthesis*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005922:Glomerulonephritis, IGA / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000378:metabolism / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D014018:Tissue Distribution; D016212:Transforming Growth Factor beta / Q000096:biosynthesis*
D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor