FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.
We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.
Xie
M H
MH
Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Holcomb
I
I
Deuel
B
B
Dowd
P
P
Huang
A
A
Vagts
A
A
Foster
J
J
Liang
J
J
Brush
J
J
Gu
Q
Q
Hillan
K
K
Goddard
A
A
Gurney
A L
AL
D000230:Adenocarcinoma; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002455:Cell Division; D002460:Cell Line; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D003001:Cloning, Molecular; D015179:Colorectal Neoplasms; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D015870:Gene Expression; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D020161:Physical Chromosome Mapping; D011485:Protein Binding / Q000187:drug effects; D021382:Protein Sorting Signals; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D012160:Retina / Q000196:embryology / Q000378:metabolism; D016415:Sequence Alignment; D013577:Syndrome; D014407:Tumor Cells, Cultured
C117476:FGF19 protein, human; D021382:Protein Sorting Signals; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D011993:Recombinant Fusion Proteins; D005346:Fibroblast Growth Factors; D006493:Heparin; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4