Genomic imprinting in mammals: an interplay between chromatin and DNA methylation?
Most imprinted loci have key regulatory elements that are methylated on only one of the parental chromosomes. For several of these 'differentially methylated regions', recent studies establish that the unmethylated chromosome has a specialized chromatin organization that is characterized by nuclease hypersensitivity. The novel data raise the question of whether specific proteins and associated chromatin features regulate the allele-specificity of DNA methylation at these imprinting control elements.
Feil
R
R
Programme in Developmental Genetics, The Babraham Institute, Cambridge, UK CB2 4AT. robert.feil@bbsrc.ac.uk
Khosla
S
S
D000483:Alleles; D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D019175:DNA Methylation; D003850:Deoxyribonuclease I / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting / Q000502:physiology*; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D003850:Deoxyribonuclease I