title: The effect of prolonged exercise on lipid peroxidation in eumenorrheic female runners.
abstract: OBJECTIVE
  Recently a protective role has been demonstrated for estrogens as free radical scavengers. In this study, lipid peroxidation was evaluated in eumenorrheic runners before and after participation in a half-marathon.
  
  
  METHODS
  Seven female runners who participated in regular training (average 25 miles x wk(-1) and reported regular menses (12/yr) served as subjects. Subjects were all in a low estrogen phase of their menstrual cycle as confirmed by menstrual record and plasma estradiol level (42.71 +/- 21.65 pg x mL(-1). Low density lipoprotein oxidation (formation of conjugated dienes) was determined 2 h prerace and 5 min after subject's completion of the race.
  
  
  RESULTS
  Results showed a significant increase in lag phase time of conjugated dienes after prolonged exercise (28.43 +/- 4.89 min vs postrace 35.21 +/- 4.32 min, P < 0.05). No correlation between mean levels of estradiol and mean lipid peroxidation levels at rest, 5 min after exercise, or difference (prepost) was observed.
  
  
  CONCLUSIONS
  Prolonged endurance exercise does not appear to increase potential for lipid peroxidation in trained eumenorrheic runners during a low estrogen phase of the menstrual cycle.
authors.affiliation: Department of Health and Sport Science, University of Dayton, OH 45469-1210, USA.
authors.forename: D
authors.initials: D
authors.lastname: Case
authors.forename: J T
authors.initials: JT
authors.lastname: Baer
authors.forename: M T
authors.initials: MT
authors.lastname: Subbiah
mesh_terms: D000328:Adult; D004958:Estradiol / Q000032:analysis; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008597:Menstrual Cycle / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology; D012420:Running / Q000502:physiology*
chemical_list: D004958:Estradiol