Developmental regulation of the dopamine D1 receptor in human caudate and putamen.
Perturbations in the developmental regulation of the dopaminergic system have been hypothesized to participate in the age-dependent onset of schizophrenia. Although data from studies of non-human primates suggest that dopamine D1-like receptors decrease during adolescence, less information is available concerning changes in human brain. The present study employed quantitative receptor autoradiography to measure D1-like receptor density and affinity in human caudate and putamen. Samples were obtained postmortem from 15 subjects (9 weeks to 49 years), and grouped a priori into three classes: infants, adolescents, and adults. Receptor density and affinity were assessed by saturation binding with [3H]-SCH23390, a D1 receptor antagonist. A decrease in D1 receptor density was observed from infancy to adulthood, with no change in receptor affinity. The temporal pattern of D1-like receptor expression during maturation may play a role in the interaction of dopamine with other neurotransmitter systems, and in the occurrence and pharmacotherapy of neurological and neuropsychiatric disorders.
Montague
D M
DM
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599-7160, USA.
Lawler
C P
CP
Mailman
R B
RB
Gilmore
J H
JH
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001345:Autoradiography; D001552:Benzazepines / Q000494:pharmacology*; D001665:Binding Sites; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000000981:diagnostic imaging / Q000254:growth & development* / Q000378:metabolism*; D011869:Radioligand Assay; D011877:Radionuclide Imaging; D017447:Receptors, Dopamine D1 / Q000502:physiology*; D012559:Schizophrenia / Q000378:metabolism
D001552:Benzazepines; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1