title: Effects of restorative proctocolectomy on renal and adrenal function.
abstract: OBJECTIVE
  Restorative proctocolectomy is a standard procedure in the surgical treatment of ulcerative colitis and familial adenomatous polyposis. The radical removal of the colorectum with construction of an ileostomy often results in high stoma losses. These may lead to changes in the electrolyte and acid-base balance and to alterations in renal and suprarenal gland function.
  
  
  METHODS
  In this study 33 patients who received an ileoanal pouch before and after proctocolectomy were investigated at different time intervals for electrolyte changes, alteration of the acid-base balance, kidney function, and hormonal changes of the suprarenal glands. Measurements were performed before proctocolectomy, ten days after proctocolectomy with ileal pouch-anal anastomosis under protective loop ileostomy, before ileostomy closure, and 6 to 12 months after ileostomy closure. Neither acute renal failure nor other vital complications were observed.
  
  
  RESULTS
  Statistical analysis showed a significant decrease of urine pH to 5.4 +/- 0.22 (before ileostomy closure) and metabolic acidosis (pH 7.32 +/- 0.04; base excess -1.3 +/- 5.6 (before ileostomy closure)). Likewise, we found a decrease in renal clearance to 86 ml/minute (before ileostomy closure) without signs of tubular damage. The most important change during the phase with ileostomy was a functional secondary hyperaldosteronism with aldosterone levels of 63.2 +/- 70.8 ng/dl (before ileostomy closure). In comparison with preoperative levels, there was a ten-fold increase in mineralocorticoid adrenal activity. Additionally, during the period with protective ileostomy, the hepatic synthesis of aldosterone-18-glucuronide was only slightly increased, and the cortisol/cortisone ratio was extremely decreased.
  
  
  CONCLUSIONS
  These results show that restorative proctocolectomy with ileal pouch-anal anastomosis and protective loop ileostomy significantly influences fluid, electrolyte, and acid-base balance. Functional secondary hyperaldosteronism is of central importance for subsequent renal recompensation. Approximately one-half year after ileostomy closure, the endogenous hormones with mineralocorticoid effects returned to normal levels.
authors.affiliation: Department of Surgery, University of Heidelberg, Germany.
authors.forename: F X
authors.initials: FX
authors.lastname: Huber
authors.forename: J
authors.initials: J
authors.lastname: Stern
authors.forename: U
authors.initials: U
authors.lastname: Hinz
authors.forename: E
authors.initials: E
authors.lastname: Werle
authors.forename: D
authors.initials: D
authors.lastname: Haack
authors.forename: P
authors.initials: P
authors.lastname: Kienle
authors.forename: U
authors.initials: U
authors.lastname: Heuschen
authors.forename: M
authors.initials: M
authors.lastname: Aulmann
authors.forename: C
authors.initials: C
authors.lastname: Decker-Baumann
authors.forename: C
authors.initials: C
authors.lastname: Herfarth
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000305:Adrenal Cortex Hormones / Q000032:analysis; D000311:Adrenal Glands / Q000503:physiopathology*; D003093:Colitis, Ulcerative / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000209:etiology / Q000503:physiopathology; D007081:Ileostomy; D007668:Kidney / Q000503:physiopathology*; D016737:Proctocolectomy, Restorative; D011446:Prospective Studies; D013997:Time Factors; D016482:Urinalysis; D014556:Urine; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones