title: Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring.
abstract: Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2-dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
authors.affiliation: Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago, Santiago de Compostela, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Blanco
authors.forename: O
authors.initials: O
authors.lastname: Caamaño
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: X
authors.initials: X
authors.lastname: García-Mera
authors.forename: A R
authors.initials: AR
authors.lastname: Hergueta
authors.forename: C
authors.initials: C
authors.lastname: López
authors.forename: J E
authors.initials: JE
authors.lastname: Rodríguez-borges
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000494:pharmacology; D029822:Enterovirus B, Human / Q000187:drug effects; D006151:Guanosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D014616:Vaccinia virus / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003503:Cyclobutanes; D006151:Guanosine