Oligodendroglial gliomatosis cerebri: (1)H-MRS suggests elevated glycine/inositol levels.
Oligodendroglial gliomatosis cerebri is very rare. We describe 42-year-old woman who had low-grade oligodendroglial gliomatosis cerebri confirmed on stereotactic biopsy. The diffuse nature of the tumour was apparent clinically, neurophysiologically, on MRI and on proton magnetic resonance spectroscopy (MRS). She also had an isolated, false-localising partial seventh nerve palsy. MRS, of which there are no previous reports, suggested elevated glycine/inositol levels. This might be explained by the cell lineage from which the tumour arose.
Gutowski
N J
NJ
The National Hospital for Neurology and Neurosurgery and The Institute of Neurology, London, UK.
Gómez-Ansón
B
B
Torpey
N
N
Revesz
T
T
Miller
D
D
Rudge
P
P
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001707:Biopsy, Needle; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009836:Oligodendroglia / Q000473:pathology; D009837:Oligodendroglioma / Q000175:diagnosis / Q000473:pathology*; D013238:Stereotaxic Techniques; D013702:Temporal Lobe / Q000473:pathology
D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D005998:Glycine