[The effect of tropoxin on the neurogenic and vasogenic inflammation of the dura mater vessels].
Subchronic administration of tropoxin (in doses of 7.5 and 10 mg/kg) caused dose-dependent blocking of 131I-albumin plasma transudation from the dura mater vessels, induced by electrical stimulation of the trigeminal ganglion and intravenous infusion of the agonist of 5-HT2B/2C receptors metachlorophenylpiperazine. The antimigraine agent metisergid produced a similar effect. A single injection of metisergid and tropoxin did not block albumin transudation. A 3 mg/kg dose of mianserin prevented the blocking effect of tropoxin and metisergid on plasma exudation into the dura mater. It is suggested that the mechanism of the tropoxin antimigraine effect is realized through the presynaptic 5-HT1 receptors of afferent endings of the trigeminal nerve and the postsynaptic 5-HT2B/2C receptors of the dura mater vessels.
Amelin
A V
AV
Valdman Institute of Pharmacology, St. Petersburg, Russia.
Ivanov
V E
VE
Ignatov
Iu D
IuD
Tumelevich
B Ch
BCh
Pushkarev
A A
AA
Usachev
N I
NI
D000818:Animals; D001372:Aza Compounds / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004388:Dura Mater / Q000098:blood supply* / Q000378:metabolism; D008297:Male; D008784:Methysergide / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism; D020293:Vasculitis, Central Nervous System / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D010879:Piperazines; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D012711:Serum Albumin, Radio-Iodinated; C015068:1-(3-chlorophenyl)piperazine; D008784:Methysergide