[The use of sirdalud in cerebral palsy in children].
30 diplegic children (mean age 11.3 +/- 2.8 years old) with severe form of cerebral palsy received sirdalud monotherapy during 2-6 weeks (1 mg for children under 10 years old and 2 mg for older children, 3 times daily). Positive effects were determined in motor, autonomic and mental (emotional) spheres. Sirdalud was also very effective in patients after orthopedic-surgical treatment. Electroneuromyographic analysis showed the decrease of the synergic tonic activity, as well as the improvement of the supraspinal influences and the segmental interaction. Thus, the small doses of sirdalud are effective without side effects in children with cerebral palsy.
Brin
I L
IL
Kurenkov
A L
AL
Gotlib
V Ia
VIa
D000293:Adolescent; D002547:Cerebral Palsy / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D002648:Child; D003000:Clonidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004576:Electromyography / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D013997:Time Factors
D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine