Inhibitory effect of shark liver oil on cutaneous angiogenesis induced in Balb/c mice by syngeneic sarcoma L-1, human urinary bladder and human kidney tumour cells.
The effect of shark liver oil on cutaneous angiogenesis induced in mice by intradermal grafting of tumour cells was evaluated. It was shown that this substance (Ecomer) suppressed neovascular response in mice grafted with sarcoma L-1 syngeneic cells, human kidney cancer and human urinary bladder cancer cells. In addition, strong stimulatory effect of this drug on mice blood granulocyte number and their metabolic activity was observed.
Skopinska-Rózewska
E
E
National Institute of Tuberculosis and Lung Diseases, Department of Immunology, 01-138 Warsaw, Poland.
Krotkiewski
M
M
Sommer
E
E
Rogala
E
E
Filewska
M
M
Bialas-Chromiec
B
B
Pastewka
K
K
Skurzak
H
H
D000818:Animals; D005395:Fish Oils / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D012513:Sarcoma, Experimental / Q000098:blood supply* / Q000188:drug therapy / Q000473:pathology; D012754:Sharks; D012867:Skin / Q000098:blood supply*; D001749:Urinary Bladder Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000473:pathology
D005395:Fish Oils