title: A case of melanonychia caused by Exophiala dermatitidis.
abstract: We report a case of a healthy 61-year-old woman with discoloration of the nail on her right big toe. We first treated her with topical steroid and urea under suspected diagnosis of nail eczema, but the lesion remained. In culture, black, shiny, pasty and yeast-like colonies grew repeatedly. Examination of debris from her nail showed dematiaceous spherical cells and hyphal elements. Microscopically, annelloconidia were produced at the apical ends of anellidic conidiogenous cells. This colony grew at 40C. Mitochondrial DNA restriction fragment length polymorphism was analysed in this strain and its restriction pattern confirmed the isolate to be Exophiala dermatitidis. Based on these findings, we diagnosed this nail deformity as fungal melanonychia due to Exophiala dermatitidis. This is the third reported case of this disease.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hata
authors.forename: W
authors.initials: W
authors.lastname: Naka
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D005093:Exophiala; D005260:Female; D006801:Humans; D008875:Middle Aged; D009181:Mycoses; D009260:Nail Diseases / Q000382:microbiology*; D010859:Pigmentation Disorders / Q000209:etiology*