title: Association of IgA nephropathy with Clostridium difficile colitis.
abstract: Immunoglobulin A (IgA) nephropathy, the most common cause of glomerulonephritis worldwide, is usually idiopathic in origin and renal limited. Secondary IgA nephropathy has been associated with systemic disease, including such gastrointestinal tract disturbances as celiac sprue and inflammatory bowel disease. We describe gross hematuria and reversible acute renal failure from IgA nephropathy in a patient with cephalosporin-induced Clostridium difficile colitis. In addition to mesangial IgA and C3 deposition, renal histological examination showed glomerular bleeding, intratubular red blood cell casts, and acute tubular necrosis. To the best of our knowledge, this is the first report of an association between IgA nephropathy and C difficile colitis.
authors.affiliation: Division of Nephrology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. william.gaughan@mail.tju.edu
authors.forename: W J
authors.initials: WJ
authors.lastname: Gaughan
authors.forename: M H
authors.initials: MH
authors.lastname: Hassan
authors.forename: P A
authors.initials: PA
authors.lastname: McCue
authors.forename: J F
authors.initials: JF
authors.lastname: Burke
authors.forename: K
authors.initials: K
authors.lastname: Sharma
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology; D000328:Adult; D020682:Cefixime; D002439:Cefotaxime / Q000009:adverse effects / Q000031:analogs & derivatives; D002511:Cephalosporins / Q000009:adverse effects; D016360:Clostridioides difficile; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000150:complications*; D005260:Female; D005922:Glomerulonephritis, IGA / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000473:pathology
chemical_list: D002511:Cephalosporins; D020682:Cefixime; D002439:Cefotaxime