Some studies on the rodenticidal action of indomethacin.
The oral LD50 of indomethacin for a seven-day observation was found to be 12.58 +/- 1.15 mg/kg. At LD10 of 6.61 mg/kg, a dose to weight ratio of 28 was obtained for a 240 g rat, while at a maximum single dose of 3 mg/kg in man it is only 0.04. Neither diazepam nor phenobarbital influenced death at the doses of both drugs used. However, cholestyramine 2 g/kg/day was found to protect by 50% from the LD100 of indomethacin. Gross pathological studies showed dose-dependent ulceration and perforation (P < 0.001, 12 vs 24 mg/kg) and such lesions occurred in starved rats, were low in bile duct-ligated compared to sham-operated rats (P < 0.001) and were also low in cholestyramine-treated rats. Indomethacin-induced lethality in rats was found to be dose-dependent.
Omogbai
E K
EK
Department of Pharmacology & Toxicology, University of Benin, Nigeria.
Ozolua
R I
RI
Idaewor
P E
PE
Isah
A O
AO
D000284:Administration, Oral; D000818:Animals; D001652:Bile Ducts / Q000601:surgery; D001835:Body Weight / Q000187:drug effects; D002792:Cholestyramine Resin / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D007213:Indomethacin / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D010439:Peptic Ulcer Perforation / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012375:Rodent Control / Q000379:methods; D012378:Rodenticides / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D018675:Toxicity Tests
D012378:Rodenticides; D002792:Cholestyramine Resin; D003975:Diazepam; D007213:Indomethacin; D010634:Phenobarbital