title: A collagen network formation effector from leaves of Premna subscandens.
abstract: As a part of the search for biologically active plant products, M cells, which form a collagen fiber network in vitro after a prolonged culture period, were used. The n-BuOH-soluble fraction of a methanol extract of leaves of Premna subscandens exhibited promotion of collagen network formation by M cells. Extensive isolation work guided by a bioassay afforded a phenylethanoid, acteoside, as an active compound.
authors.affiliation: Institute of Pharmaceutical Sciences, Hiroshima University Faculty of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sudo
authors.forename: K
authors.initials: K
authors.lastname: Kijima
authors.forename: H
authors.initials: H
authors.lastname: Otsuka
authors.forename: T
authors.initials: T
authors.lastname: Ide
authors.forename: E
authors.initials: E
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Isaji
authors.forename: Y
authors.initials: Y
authors.lastname: Kurashina
mesh_terms: D002460:Cell Line; D003094:Collagen / Q000378:metabolism*; D004396:Coloring Agents; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013268:Stimulation, Chemical
chemical_list: D004396:Coloring Agents; D010936:Plant Extracts; D003094:Collagen