Salivary duct carcinoma in five cats.
Carcinomas of salivary gland ducts are described in five cats. The typical histological pattern was the formation of large cell aggregates resembling dilated ducts, often with central necrosis and a looping pattern. All tumours were labelled with antibody to cytokeratins (CKs) 5, 6, 8, 14, 17 and 19. Labelling of tumour cells with CK14 suggested basal cell differentiation. All tumours stained with Jack bean (Canavalia ensiformis) agglutinin (Con A); this is a feature of normal salivary gland ducts but is seen in other salivary gland tumours. Staining of tumour cells at the luminal surface of ductal structures with wheat germ (Triticum vulgaris) agglutinin (WGA) in the cat tumours was similar to that seen in ducts of normal cat salivary glands but occurs in other cat tumours. Other immunohistochemical staining results were unremarkable. 1999 Harcourt Publishers Ltd.
Sozmen
M
M
Comparative Pathology Laboratory, University of Bristol, Veterinary School, Langford, Bristol, BS40 5DU, UK.
Brown
P J
PJ
Eveson
J W
JW
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005260:Female; D007124:Immunoenzyme Techniques / Q000662:veterinary; D007633:Keratins / Q000032:analysis; D008297:Male; D018987:Salivary Ducts / Q000737:chemistry / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*
D014408:Biomarkers, Tumor; D007633:Keratins