title: Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1.
abstract: Non-invasive delivery of peptide and protein drugs will soon become a reality. This is due partly to a better understanding of the endogenous transport mechanisms, including paracellular transport, endocytosis, and carrier-mediated transport of mucosal routes of peptide and protein drug administration. This paper focuses on work related to the elucidation of structure-function, intracellular trafficking, and regulation of the intestinal dipeptide transporter, PepT1.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA. vincentL@hsc.usc.edu
authors.forename: V H
authors.initials: VH
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Chu
authors.forename: E D
authors.initials: ED
authors.lastname: Mahlin
authors.forename: S K
authors.initials: SK
authors.lastname: Basu
authors.forename: D K
authors.initials: DK
authors.lastname: Ann
authors.forename: M B
authors.initials: MB
authors.lastname: Bolger
authors.forename: I S
authors.initials: IS
authors.lastname: Haworth
authors.forename: A K
authors.initials: AK
authors.lastname: Yeung
authors.forename: S K
authors.initials: SK
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Hamm-Alvarez
authors.forename: C T
authors.initials: CT
authors.lastname: Okamoto
mesh_terms: D001692:Biological Transport; D001702:Biopharmaceutics; D002352:Carrier Proteins / Q000493:pharmacokinetics*; D004151:Dipeptides / Q000493:pharmacokinetics*; D009092:Mucous Membrane / Q000378:metabolism; D009842:Oligopeptides / Q000493:pharmacokinetics*; D000074011:Peptide Transporter 1; D011506:Proteins / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship; D027981:Symporters
chemical_list: D002352:Carrier Proteins; D004151:Dipeptides; D009842:Oligopeptides; D000074011:Peptide Transporter 1; D011506:Proteins; D027981:Symporters