Role of insulin-like growth factor binding protein 1 in human pregnancy.
Insulin-like growth factors and their binding proteins are key regulators of fetal and maternal tissue growth and development during human pregnancy. Insulin-like growth factors, particularly IGF-II, are produced in abundance by the trophoblast cells of the placenta, whereas one of the insulin-like growth factor binding proteins, IGFBP-1, is the major secretory product of the maternal decidualized endometrium. This spatial (and temporal expression) of the insulin-like growth factor axis infers a sophisticated paracrine regulatory mechanism for controlling insulin-like growth factor function. This paper reviews the potential roles of IGFBP-1 in human pregnancy by examining its effects on growth, metabolism and migration at the maternal-fetal interface and how these might be influenced by autocrine-paracrine post-translational modifications.
Westwood
M
M
Department of Medicine, University of Manchester, UK.
D000818:Animals; D019898:Autocrine Communication; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000502:physiology*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D051379:Mice; D019899:Paracrine Communication; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000502:physiology*; D011499:Protein Processing, Post-Translational
D018970:Insulin-Like Growth Factor Binding Protein 1; D011257:Pregnancy Proteins