Pharmacological improvement of large arteries properties.
Arterial distensibility reflects mechanical properties of the arterial wall and have, thus a clearcut clinical relevance. This because an arterial distensibility reduction is associated with an increased pulse pressure, an increased cardiac work and a reduced diastolic vital organ perfusion. In recent years it has been demonstrated that arterial distensibility is reduced in marked and mild hypercholesterolemia, in a manner independent from arterial blood pressure values. Arterial mechanical properties are also impaired in heart failure, this leading to a further cardiac damage. This important vascular properties however, can be improved by appropriate treatment, while the time needed for that can be extremely long.
Giannattasio
C
C
Ospedale S. Gerardo dei Tintori, Monza, Italy.
Failla
M
M
Calchera
I
I
Grieco
N
N
Scandola
L
L
Grappiolo
A
A
Mancia
G
G
D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D014664:Vasodilation / Q000187:drug effects
D000960:Hypolipidemic Agents