title: Pharmacological improvement of large arteries properties.
abstract: Arterial distensibility reflects mechanical properties of the arterial wall and have, thus a clearcut clinical relevance. This because an arterial distensibility reduction is associated with an increased pulse pressure, an increased cardiac work and a reduced diastolic vital organ perfusion. In recent years it has been demonstrated that arterial distensibility is reduced in marked and mild hypercholesterolemia, in a manner independent from arterial blood pressure values. Arterial mechanical properties are also impaired in heart failure, this leading to a further cardiac damage. This important vascular properties however, can be improved by appropriate treatment, while the time needed for that can be extremely long.
authors.affiliation: Ospedale S. Gerardo dei Tintori, Monza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Giannattasio
authors.forename: M
authors.initials: M
authors.lastname: Failla
authors.forename: I
authors.initials: I
authors.lastname: Calchera
authors.forename: N
authors.initials: N
authors.lastname: Grieco
authors.forename: L
authors.initials: L
authors.lastname: Scandola
authors.forename: A
authors.initials: A
authors.lastname: Grappiolo
authors.forename: G
authors.initials: G
authors.lastname: Mancia
mesh_terms: D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000960:Hypolipidemic Agents