[The use of the clinical biochemical Epitest kit in children with epilepsy].
57 children aged 3-15 years were examined: children with epilepsy (n = 26), children with epileptic syndrome (n = 16) and children with other neurologic pathology (n = 15). Control group included 25 healthy children. Diagnostic efficiency of the epileptic test was investigated on the basis of the detection of autoantibodies (aAb) to glutamate receptor of AMPA type in blood serum of the patients. It was shown that children with epilepsy had elevated level of aAb to AMPA receptors in blood in comparison with that of the healthy children. The level of aAb to AMPA receptors correlated with severity of the disease and location of the epileptic focus. The authors recommend the "Epitest" as an additional biochemical tool for differential diagnosis of children's epilepsy.
Iatsuk
S L
SL
Izykenova
G A
GA
Skuliabin
D I
DI
Dambinova
S A
SA
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000097:blood / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D006801:Humans; D011933:Reagent Kits, Diagnostic; D018091:Receptors, AMPA / Q000276:immunology; D012680:Sensitivity and Specificity; D013577:Syndrome
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D011933:Reagent Kits, Diagnostic; D018091:Receptors, AMPA