title: Population based study on serum ionised calcium, serum parathyroid hormone, and blood pressure. The Tromsø study.
abstract: OBJECTIVE
  To study associations between serum ionised calcium, serum parathyroid hormone (PTH) and blood pressure.
  
  
  METHODS
  A population based, cross-sectional study was used.
  
  
  METHODS
  Blood pressure, body mass index, serum ionised calcium and serum PTH were measured in 460 males and 486 females in the Tromso study in 1994/1995. None were on medication for hypertension. The data were analysed with a multiple linear regression model.
  
  
  RESULTS
  When looking at subjects with serum ionised calcium<1.39mmol/l, there was a significant negative association (P<0.01) between serum ionised calcium and PTH. There was no association between blood pressure and serum ionised calcium. In both sexes there was a significant positive association between age and serum PTH (P<0.01). For women, but not for men, there was a significant positive association between serum PTH and systolic and diastolic blood pressure (P<0.01). Within each age group there was a difference in both systolic and diastolic blood pressure of 3-10mmHg between the upper and lower serum PTH halves of the female population. Females with hypertension had significantly higher serum PTH levels than the normotensive females (P<0.01).
  
  
  CONCLUSIONS
  Serum PTH is strongly and positively associated with blood pressure in women.
authors.affiliation: Department of Medicine, University Hospital of Tromso, Tromso, Norway. medrj@rito.no
authors.forename: R
authors.initials: R
authors.lastname: Jorde
authors.forename: K H
authors.initials: KH
authors.lastname: Bonaa
authors.forename: J
authors.initials: J
authors.lastname: Sundsfjord
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007477:Ions; D008297:Male; D008875:Middle Aged; D009664:Norway; D010281:Parathyroid Hormone / Q000097:blood*; D011159:Population Surveillance; D012044:Regression Analysis
chemical_list: D007477:Ions; D010281:Parathyroid Hormone; D002118:Calcium