title: Daily response of blood pressure to day-to-day variation of urinary sodium to potassium ratio.
abstract: The relationship between blood pressure and urinary sodium-to-potassium (Na/K) ratio was assessed in eight healthy men, none of whom used antihypertensive medications. Blood pressure and urinary sodium and potassium concentrations were measured for 11 to 33 days without any dietary restriction. For two of the eight subjects, the urinary Na/K ratio significantly correlated with systolic blood pressure (r=0.70 and 0.45, respectively), and in one of the two subjects, the urinary ratio also positively correlated with diastolic blood pressure (r=0.72). In the others, no relationship between the ratio and blood pressure was observed (r=-0.24 to 0.26). The results indicate that, in some individuals, the daily variation of urinary Na/K ratio is closely correlated with day-to-day changes in blood pressure level, and suggest that the urinary Na/K ratio is useful in the management of the daily sodium and potassium intake balance of hypertensive patients who need to restrict salt intake.
authors.affiliation: Department of Public Health, Nagasaki University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: K
authors.initials: K
authors.lastname: Moji
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Takemoto
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Satoh
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004039:Diet, Sodium-Restricted; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000517:prevention & control / Q000652:urine; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine*; D017419:Potassium, Dietary / Q000009:adverse effects; D012016:Reference Values; D012964:Sodium / Q000652:urine*; D012982:Sodium, Dietary / Q000009:adverse effects
chemical_list: D015415:Biomarkers; D017419:Potassium, Dietary; D012982:Sodium, Dietary; D012964:Sodium; D011188:Potassium