Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing.
A new human cDNA was cloned and termed alpha-catulin, based on sequence similarity with both alpha-CATenins and vincULIN. The mRNA is present ubiquitously, although low expression levels are found in neural tissues. The genomic organization of the alpha-catulin gene CTNNAL1 is closely related to that of the alphaE-catenin gene CTNNA1, but not at all to that of the vinculin gene. Alternative splicing of the last exon generates a frameshift, resulting in a truncated protein with a new carboxy-terminus.
Janssens
B
B
Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology (VIB)-University of Ghent, B-9000, Ghent, Belgium.
Staes
K
K
van Roy
F
F
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D017124:Conserved Sequence; D003598:Cytoskeletal Proteins / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017421:Sequence Analysis; D051178:alpha Catenin
C495273:CTNNA1 protein, human; C495274:CTNNAL1 protein, human; D003598:Cytoskeletal Proteins; D018076:DNA, Complementary; D051178:alpha Catenin