[Separate and combined mutagenic effect of radiation and asbestos on the micronucleus test in experiments].
We investigated the isolated and combined mutagenic effect (ME) of radiation (gamma-irradiation, 0.5 or 2 Gy) and asbestos (i.p. 10 mg/mice) in mice CBA. We studied also the antioxidant activity and malonic dialdehyde concentration in blood serum as possible mechanism of ME and its possible modification. For the ME the micro-nuclei incidence in polychromatic bone marrow erythrocytes was scored. The reciprocal modification (potentiation) of both radiation and asbestos ME was established for combination "radiation, 2 Gy + asbestos", the additivity--for combination "radiation, 0.5 Gy + asbestos".
Frash
V N
VN
Scientific Research Institute of Pulmonology, Ural Division, Ekaterinburg, Russia. 2175@dialup.mplik.ru
Pavlov
V A
VA
Ubakov
S A
SA
D000818:Animals; D001194:Asbestos / Q000009:adverse effects*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D016296:Mutagenesis / Q000187:drug effects* / Q000528:radiation effects*; D011829:Radiation Dosage; D013997:Time Factors
D001194:Asbestos