title: Splenomegaly at a university hospital compared to a nearby county hospital in 317 patients.
abstract: Splenomegaly and massive splenomegaly were diagnostically evaluated retrospectively at Stanford University Hospital in 147 patients over 8 years and compared to the nearby county hospital (Santa Clara Valley Medical Center; VMC) in 170 inpatients over 11 years. Hematologic diseases at Stanford (data for VMC in parentheses) occurred in 66% (35%; p < 0.001) of the patients with splenomegaly and in 84% (54%; p < 0.001) of those with massive splenomegaly. Hepatic diseases occurred in 9% (36%; p < 0.001) of the patients with splenomegaly and in 5% (29%; p < 0.001) of those with massive splenomegaly. Splenectomy was performed in 71% of the patients at Stanford and in 9% of those at VMC (p < 0.001). The combined Stanford-VMC series showed significant associations (p < 0.01): for hematologic diseases with massive splenomegaly, lymphadenopathy, and blood cytoses; for hepatic diseases with hepatomegaly, cytopenias as hypersplenism, and abnormal liver function tests, and for infectious diseases with fever.
authors.affiliation: Departments of Medicine, Stanford University Medical Center, Stanford, CA and Santa Clara Valley Medical Center, San Jose, CA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Swaroop
authors.forename: R A
authors.initials: RA
authors.lastname: O'Reilly
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002140:California; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006766:Hospitals, County; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D008206:Lymphatic Diseases; D008875:Middle Aged; D012189:Retrospective Studies; D013156:Splenectomy; D013163:Splenomegaly / Q000175:diagnosis* / Q000601:surgery