Adult T-cell leukemia/lymphoma in which the pathohistological diagnosis was identical to that of Ki-1 positive anaplastic large cell lymphoma.
A 65-year-old man developed severe lumbago and a loss of appetite two months before presentation. A computerized tomograph at admission revealed soft tissue masses destroying the Th12, L4 and L5 vertebral bones. We diagnosed the lesions to be metastatic bone tumors, but the primary focus could not be determined. Just after the irradiation treatment, abnormal lymphocytes were detected in the peripheral blood cells. Under the suspicion of adult T-cell leukemia/ lymphoma (ATL), we thus performed a lymph node biopsy. The specimens were histologically composed of Ki-1 positive anaplastic large cell lymphoma (ALCL). The lymphoma cells demonstrated a biclonal integration of HTLV-1 proviral DNA. After 6 cycles of chemotherapy, the patient has demonstrated a partial and favorable remission from ATL.
Takahara
T
T
Division of Internal Medicine, Nippon Steel Yawata Memorial Hospital, Kitakyushu.
Masutani
K
K
Kajiwara
E
E
Sadoshima
S
S
Misago
M
M
Sasaguri
Y
Y
Onoyama
K
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D008297:Male; D009382:Neoplasms, Unknown Primary; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification*; D011859:Radiography; D012074:Remission Induction; D016662:Virus Integration
D004279:DNA, Viral; D017730:Ki-1 Antigen