title: The nature of intracrine peptide hormone action.
abstract: Current theory holds that peptide hormone action results from hormone binding to cell-surface receptors, with the generation of intracellular second messengers. However, a growing body of evidence suggests that intracellular peptide hormone, either internalized or synthesized in situ, can exert physiologically relevant effects. These effects are diverse and poorly understood. I propose that such intracrine action can serve to modulate cellular function over time and thereby play a role in biological memory of various sorts, in the maintenance of hormonal responsiveness, and in cellular differentiation.
authors.affiliation: Division of Research, Alton Ochsner Medical Foundation, New Orleans, La 70121, USA.
authors.forename: R
authors.initials: R
authors.lastname: Re
mesh_terms: D002454:Cell Differentiation / Q000502:physiology*; D006728:Hormones / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D010455:Peptides / Q000378:metabolism / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology
chemical_list: D006728:Hormones; D010455:Peptides; D011956:Receptors, Cell Surface