The promise of comparative genomics in mammals.
Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.
O'Brien
S J
SJ
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA.
Menotti-Raymond
M
M
Murphy
W J
WJ
Nash
W G
WG
Wienberg
J
J
Stanyon
R
R
Copeland
N G
NG
Jenkins
N A
NA
Womack
J E
JE
Marshall Graves
J A
JA
D000818:Animals; D000829:Animals, Domestic / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D005819:Genetic Markers; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008322:Mammals / Q000235:genetics*; D009154:Mutation; D010802:Phylogeny; D012377:Rodentia / Q000235:genetics
D005819:Genetic Markers