The effect of pharmacokinetically guided acute intravenous testosterone administration on electrocardiographic and blood pressure variables.
Previous studies have demonstrated that intravenous testosterone can dilate coronary arteries and increase exercise treadmill time, but the electrocardiographic and hemodynamic effects are unknown. This trial determined the hemodynamic and electrocardiographic effects of dosing intravenous testosterone to achieve a physiologic and a superphysiologic serum testosterone concentration. Twenty men (70.6 +/- 6.2 years) had individualized testosterone bolus and continuous infusions designed to increase the serum testosterone concentration by two (physiologic) and six times baseline (superphysiologic). The men were studied on three occasions when they were randomly allocated to received a placebo, physiologic testosterone regimen, or superphysiologic testosterone regimen. Blood pressures and 12-lead electrocardiograms (ECGs) were taken preinfusion and 28 minutes after initiating the infusion on each visit. The blood pressure (systolic and diastolic) and ECG variables (PR, QRS, QT, QTc, and RR intervals) preinfusion and during the infusion were compared, and the delta changes in the variables were compared between groups. The physiologic testosterone regimen increased the serum testosterone concentration by 2.39 +/- 0.48 times the preinfusion concentration, while the superphysiologic regimen increased it by 6.22 +/- 0.99 times. No significant changes occurred in the blood pressure or ECG variables in any group versus preinfusion values or between the three groups. Exogenously administered intravenous testosterone does not significantly affect the blood pressure or ECG variables when given to achieve physiologic or superphysiologic concentrations.
White
C M
CM
Nuclear Cardiology and Exercise Physiology Laboratory, Hartford Hospital Division of Cardiology, CT 06102-5037, USA.
Ferraro-Borgida
M J
MJ
Moyna
N M
NM
McGill
C C
CC
Ahlberg
A W
AW
Thompson
P D
PD
Heller
G V
GV
D000368:Aged; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D003971:Diastole; D004311:Double-Blind Method; D004562:Electrocardiography; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000493:pharmacokinetics*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013599:Systole; D013739:Testosterone / Q000097:blood / Q000493:pharmacokinetics*
D012739:Gonadal Steroid Hormones; D013739:Testosterone