Comparison of ketoprofen and carprofen administered prior to orthopedic surgery for control of postoperative pain in dogs.
OBJECTIVE
To compare analgesic and adverse effects of ketoprofen and carprofen when used to control pain associated with elective orthopedic surgeries in dogs.


METHODS
Prospective randomized clinical trial.


METHODS
93 client-owned dogs: 46 undergoing reconstruction of the cranial cruciate ligament, 47 undergoing femoral head and neck excision, and 15 control dogs anesthetized for radiographic procedures.


METHODS
Dogs undergoing surgery were randomly given ketoprofen, carprofen, or saline (0.9% NaCl) solution, SC, prior to surgery. Pain score and serum cortisol concentration were recorded for 12 hours after surgery for all dogs. When pain score was > or = 7, oxymorphone was administered i.m. Bleeding time was measured prior to and during surgery.


RESULTS
The proportion of dogs that required oxymorphone was significantly higher for the carprofen and placebo groups than for the ketoprofen group. Pain score for the placebo group was significantly higher than for the ketoprofen and carprofen groups, 2, 8, and 9 hours after surgery. Cortisol concentration was significantly higher for the placebo group than for the carprofen group at 4 and 6 hours after surgery. Significant differences were not detected between ketoprofen and carprofen groups with respect to pain score and cortisol concentration. Bleeding time was significantly longer for the ketoprofen group than for the other groups during surgery. One dog treated with ketoprofen developed a hematoma at the surgical site.


CONCLUSIONS
Ketoprofen and carprofen given prior to surgery were effective for postoperative pain relief in dogs. However, ketoprofen should not be used when noncompressible bleeding may be a problem.
Grisneaux
E
E
Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, PQ, Canada.
Pibarot
P
P
Dupuis
J
J
Blais
D
D
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001760:Bleeding Time / Q000662:veterinary; D016063:Blood Loss, Surgical / Q000662:veterinary; D001794:Blood Pressure; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D000075202:Contraindications; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D004283:Dog Diseases / Q000517:prevention & control / Q000601:surgery*; D004285:Dogs; D004311:Double-Blind Method; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D011229:Preanesthetic Medication / Q000662:veterinary*; D011446:Prospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D016861:Cyclooxygenase Inhibitors; D007660:Ketoprofen; C007005:carprofen; D006854:Hydrocortisone