title: Comparison of nitroglycerin lingual spray and sublingual tablet on time of onset and duration of brachial artery vasodilation in normal subjects.
abstract: This study compared the rapidity of onset, the magnitude, and the duration of action of 2 short-acting nitroglycerin preparations using high-resolution brachial ultrasound. Both sublingual tablet and lingual spray formulations caused maximal vasodilation at 3 minutes; however, the spray provided faster (at 2 minutes), greater, and more prolonged (15 minutes) vasodilation than the tablet.
authors.affiliation: Department of Medicine, Montreal Heart Institute, Quebec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Ducharme
authors.forename: J
authors.initials: J
authors.lastname: Dupuis
authors.forename: S
authors.initials: S
authors.lastname: McNicoll
authors.forename: F
authors.initials: F
authors.lastname: Harel
authors.forename: J C
authors.initials: JC
authors.lastname: Tardif
mesh_terms: D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D000336:Aerosols; D000704:Analysis of Variance; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage*; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D000336:Aerosols; D014665:Vasodilator Agents; D005996:Nitroglycerin