title: [Serum pro-oxidant and antioxidant factors and risk of Parkinson's disease: population study].
abstract: BACKGROUND
  Several studies suggested a role of 'oxidative stress' (increased production of prooxidants, antioxidants deficiencies or both) in the pathogenesis of Parkinson's disease. In this study we have measured the serum levels of a number of prooxidant and antioxidant substances to evaluate their possible relation with the risk for Parkinson's disease.
  
  
  METHODS
  We assessed the serum levels of iron, ferritin, ansferrin, ceruloplasmine, vitamin A, alpha-carotene, beta-carotene, and alpha-tocopherol, in 28 patients with Parkinson's disease and 85 matched controls. All of them were recruited from a population study.
  
  
  RESULTS
  None of the values studied differed significantly between the two study groups, and none of them were correlated with age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale or the Hoehn and Yahr staging in the Parkinson's disease group.
  
  
  CONCLUSIONS
  These results confirm the previous findings of classic case-control studies, suggesting the absence of relationship of the studied values with the risk for Parkinson's disease.
authors.affiliation: Servicio de Neurología, Hospital 12 de Octubre, Madrid.
authors.forename: J A
authors.initials: JA
authors.lastname: Molina-Arjona
authors.forename: F
authors.initials: F
authors.lastname: de Bustos
authors.forename: J
authors.initials: J
authors.lastname: Benito-León
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: J
authors.initials: J
authors.lastname: Rodríguez
authors.forename: R
authors.initials: R
authors.lastname: Trincado
authors.forename: J
authors.initials: J
authors.lastname: Porta-Etessan
authors.forename: S
authors.initials: S
authors.lastname: Vega
authors.forename: F
authors.initials: F
authors.lastname: Bermejo
mesh_terms: D017668:Age of Onset; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002338:Carotenoids / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D014168:Transferrin / Q000032:analysis; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D016877:Oxidants; D014168:Transferrin; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; C041635:alpha-carotene; D005293:Ferritins; D007501:Iron; D002570:Ceruloplasmin