title: Evaluation of the cytocompatibility of three endodontic materials.
abstract: The goal of this in vitro study was to evaluate the relative cytocompatibility of three endodontic materials: calcium hydroxide, a calcium oxide-based compound, and a zinc oxide-eugenol-based sealer. The evaluation was conducted 24, 72, and 168 h after contact with the compounds and involved three complementary techniques: a colorimetric cytotoxicity test, scanning electron microscopy, and flow cytometry. The results we obtained confirmed the initial cytotoxicity of the zinc oxide-eugenol-based sealer and showed that the calcium oxide-based compound had the same relative cytocompatibility as calcium hydroxide.
authors.affiliation: Department of Endodontics, Faculty of Dentistry, University of Rennes, France.
authors.forename: M
authors.initials: M
authors.lastname: Guigand
authors.forename: P
authors.initials: P
authors.lastname: Pellen-Mussi
authors.forename: A
authors.initials: A
authors.lastname: Le Goff
authors.forename: J M
authors.initials: JM
authors.lastname: Vulcain
authors.forename: M
authors.initials: M
authors.lastname: Bonnaure-Mallet
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D017610:Calcium Compounds / Q000633:toxicity; D002126:Calcium Hydroxide / Q000633:toxicity; D002453:Cell Cycle / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004341:Drug Evaluation; D005434:Flow Cytometry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000633:toxicity; D012387:Root Canal Filling Materials / Q000633:toxicity*; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D017610:Calcium Compounds; D010087:Oxides; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C016538:lime; D002126:Calcium Hydroxide