Radiation-induced inflammatory malignant fibrous histiocytoma of the ileum.
A case of inflammatory malignant fibrous histiocytoma of the ileum seemingly induced by radiation is described. A 50-year-old female with a past history of uterine cervical carcinoma and postoperative radiation therapy presented with abdominal pain, fever and leukocytosis. The subserosa of the distal part of the ileum showed a diffuse dense, neutrophilic and lymphocytic infiltrate with dispersed atypical, short spindle- or plump oval-shaped histiocyte-like cells. Pleomorphic mono- or multinucleated giant cells with bizarre nuclei were also intermingled in the lesion. Immunohistochemically, the tumorous atypical cells were positive for vimentin, alpha-smooth muscle actin, alpha-1 antitrypsin and granulocyte colony-stimulating factor. No EBV genomic sequences were detected by in situ hybridization. Flow cytometry showed an aneuploid DNA content with high S-phase fraction. The patient was well with no evidence of tumor at 5 months after surgery. It is important to include this type of tumor in the differential diagnosis of small intestinal lesions accompanied by fever and leukocytosis following radiation.
Fukunaga
M
M
Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Endo
Y
Y
Ushigome
S
S
D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology* / Q000601:surgery; D007082:Ileum / Q000473:pathology*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery
D016179:Granulocyte Colony-Stimulating Factor