title: Sentinel node biopsy in vulvar malignancies: a preliminary feasibility study.
abstract: Sentinel lymph node biopsies (SLNB) were investigated in 8 cases (6 squamous cell carcinomas, 2 melanomas) of vulvar malignancy. The sentinel node was detected by patent blue dye injection (1 case), pre operative lymphoscintigraphy with intra-operative gamma hand-held probe (2 cases), and combined techniques (5 cases). The procedure was successful in all cases but one (1 invasive squamous cell carcinoma) in which there was medial groin recurrence at 6 months. Nodal invasion was observed in only one case and was confined to the sentinel node. No specific morbidity related to the SLNB procedure occurred. SLNB appears to be a feasible and promising technique, however, requiring further evaluation before being considered as a reliable method to spare inguinofemoral lymphadenectomy in early-stage patients free of sentinel node metastasis, or to be substituted in screening elderly clinically node-negative females.
authors.affiliation: Department of Surgical Oncology, Paul Strauss Cancer Center, 67085 Strasbourg Cedex, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Rodier
authors.forename: J C
authors.initials: JC
authors.lastname: Janser
authors.forename: T
authors.initials: T
authors.lastname: Routiot
authors.forename: E
authors.initials: E
authors.lastname: David
authors.forename: G
authors.initials: G
authors.lastname: Ott
authors.forename: O
authors.initials: O
authors.lastname: Schneegans
authors.forename: J P
authors.initials: JP
authors.lastname: Ghnassia
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery