title: Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.
abstract: Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.
authors.affiliation: Immunology Division, Jichi Medical School, Tochigi-Ken 329-0498, Tokyo 107-0062, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishizawa
authors.forename: H
authors.initials: H
authors.lastname: Okamoto
authors.forename: F
authors.initials: F
authors.lastname: Tsuda
authors.forename: T
authors.initials: T
authors.lastname: Aikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Sugai
authors.forename: K
authors.initials: K
authors.lastname: Konishi
authors.forename: Y
authors.initials: Y
authors.lastname: Akahane
authors.forename: M
authors.initials: M
authors.lastname: Ukita
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Miyakawa
authors.forename: M
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D002213:Capsid / Q000737:chemistry / Q000235:genetics; D002908:Chronic Disease; D004266:DNA Virus Infections / Q000821:virology*; D004267:DNA Viruses / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D006518:Hepatitis Viruses / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D006525:Hepatitis, Viral, Human / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
chemical_list: D004279:DNA, Viral