Fibro-osseous lesions of the central nervous system: report of four cases and literature review.
Fibro-osseous lesions, also reported as calcifying pseudoneoplasms of the neural axis, are uncommon lesions of the CNS. We report four additional cases: two extraaxial and two intraaxial, in patients ages 33, 47, 49, and 59 years at presentation. Fibro-osseous lesions involving the CNS demonstrate variable proportions of fibrous stroma, bone, palisading spindle to epithelioid to multinucleated cells in association with a highly distinctive, perhaps pathognomonic, chondromyxoid-like matrix often distributed in a nodular pattern. This histopathologically distinctive lesion can be seen in many regions of the neuraxis, often with a dural association, and most commonly along the vertebral column. It appears to be a slow-growing lesion and, with wide excision, the prognosis is excellent. The etiology remains unclear, but the preponderance of data favors a reactive rather than neoplastic process. If this putative pseudotumor is not recognized histopathologically, a neoplastic or infectious differential might result in inappropriate investigations and potentially harmful therapies.
Qian
J
J
Department of Pathology, Strong Memorial Hospital, University of Rochester, New York 14642, USA.
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Powers
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Rosenblum
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Pilcher
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Shrier
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Stein
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Iannucci
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D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002356:Cartilage / Q000473:pathology; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006099:Granuloma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D014408:Biomarkers, Tumor