title: Antioxidant principles from Ephemerantha lonchophylla.
abstract: One dihydrostilbene and three phenanthrene antioxidants were isolated from an ethanolic extract of the Chinese herbal Ephemerantha lonchophylla. One of these compounds, ephemeranthone (4) is a new natural product. Denbinobin (1) and 3-methylgigantol (3) have been previously isolated from this plant, and 3-ethoxy-5-hydroxy-7-methoxy-1,4-phenanthraquinone (2) is an artifact. The structures of these compounds were determined by spectroscopic analysis. The antioxidative activities for inhibiting human low density lipoprotein oxidation in vitro of compounds 1-4 were determined, and only 4 was active (5.3 times that of probucol).
authors.affiliation: National Research Institute of Chinese Medicine, No. 155-1, Sec 2, Li Nung St., Peitou, Taipei, Taiwan, Republic of China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: M S
authors.initials: MS
authors.lastname: Shiao
authors.forename: Y L
authors.initials: YL
authors.lastname: Huang
authors.forename: C C
authors.initials: CC
authors.lastname: Shen
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL