title: Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakhstan: sources of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposures in an agricultural region of southern Kazakhstan.
abstract: High levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; up to 208 pg/g fat) were measured in samples of breast milk collected in 1997 from 64 donors [41 first-time mothers (primiparae)] living on state farms in southern Kazakhstan. TCDD was the major contributor (70%) to the toxic equivalents, matching the congener patterns found in breast milk and serum samples collected in 1994 and 1996 from donors in nearby villages. The highest TCDD levels were found in state farms adjacent to a reservoir (zone A), which receives agricultural runoff from cotton fields. TCDD levels in zone A were significantly higher than levels in a region more distant (zone B; > 10 miles) from the reservoir (zone A: mean 53 pg/g, n = 17; zone B: mean 21 pg/g, n = 24; p = 0.0017). Levels of TCDD in breast milk and animal-derived foodstuffs were 10 times U.S. levels. Body burden and dietary data suggest that exposures to TCDD are chronic, environmental, and long term and may be related to the use of chemicals in cotton agriculture. The data suggest that the most likely source is the use of cotton defoliants contaminated with TCDD, and the most likely pathway for human exposure is via the consumption of contaminated foodstuffs.
authors.affiliation: Hazardous Materials Laboratory, California Environmental Protection Agency, Berkeley 94704, USA. kim_hooper@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Hooper
authors.forename: T
authors.initials: T
authors.lastname: Chuvakova
authors.forename: G
authors.initials: G
authors.lastname: Kazbekova
authors.forename: D
authors.initials: D
authors.lastname: Hayward
authors.forename: A
authors.initials: A
authors.lastname: Tulenova
authors.forename: M X
authors.initials: MX
authors.lastname: Petreas
authors.forename: T J
authors.initials: TJ
authors.lastname: Wade
authors.forename: K
authors.initials: K
authors.lastname: Benedict
authors.forename: Y Y
authors.initials: YY
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Grassman
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism; D000383:Agriculture; D001572:Benzofurans / Q000032:analysis; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D005504:Food Analysis; D006801:Humans; D007623:Kazakhstan; D008895:Milk, Human / Q000737:chemistry*; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis*; D012424:Rural Population; D011795:Surveys and Questionnaires
chemical_list: D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins