Relationships between the modulus of elasticity and tensile strength for pharmaceutical drugs and excipients.
The relationship between the modulus of elasticity and tensile strength for a variety of pharmaceutical drugs and excipients has been explored as a means of generating algorithms for use in computer simulations and expert systems. From literature data two equations have been developed to enable the formulator, from knowledge of one property, to predict the other with a reasonable degree of accuracy. Such relationships are invaluable for use in computer simulation programs or formulation expert systems, enabling formulators to screen potential formulations quickly without the need for extensive experimental work.
Roberts
R J
RJ
Zeneca Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, UK. ron.roberts@alderley.zeneca.com
Rowe
R C
RC
D000465:Algorithms; D003198:Computer Simulation; D004548:Elasticity; D005079:Excipients; D008433:Mathematics; D004364:Pharmaceutical Preparations; D013718:Tensile Strength
D005079:Excipients; D004364:Pharmaceutical Preparations