[Therapeutic potential of glucocorticoids inhalation in bronchial asthma].
OBJECTIVE
To assess effectiveness and safety of inhalation glucocorticoids (budesonide, beklometasone dipropionate) in bronchial asthma (BA).


METHODS
19 BA patients (8 males and 11 females) inhaled glucocorticoids for 9 months.


RESULTS
The treatment reduced the need in inhalation of short-acting beta-2-adrenomimetics, episodes of asphyxia occurred less frequently. A significant improvement of bronchial permeability was achieved only after 3 months of therapy. Blood levels of hydrocortisone, concentrations of magnesium, calcium and potassium in the serum, red cells and 24-h urine, serum osteocalcin, lumbar vertebral tissue density 3, 6 and 9 months after the treatment start were almost similar to the baseline.


CONCLUSIONS
Glucocorticoids for inhalation are clinically effective in BA. They should be used for not less than 3 months. Topical steroids in mean therapeutic doses had no negative effects on the levels of hydrocortisone, mineral metabolism and bone tissue.
Emel'ianov
A V
AV
Shevelev
S E
SE
Amosov
V I
VI
Murzin
B A
BA
Shubin
S A
SA
D000280:Administration, Inhalation; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001507:Beclomethasone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001980:Bronchi / Q000378:metabolism; D019819:Budesonide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010539:Permeability; D011188:Potassium / Q000097:blood; D012129:Respiratory Function Tests; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D015675:Osteocalcin; D019819:Budesonide; D008274:Magnesium; D001507:Beclomethasone; D011188:Potassium; D002118:Calcium; D006854:Hydrocortisone