Semisynthesis and cytotoxicity of amino acetogenins and derivatives.
Semisynthetic derivatives were prepared from two natural annonaceous acetogenins, rolliniastatin-1 and squamocin, and their cytotoxicity was evaluated. Amino derivatives show decreased bioactivity. Isorolliniastatin-1 was found to be much less toxic than rolliniastatin-1 after intraperitoneal administration to mice, although the in vitro cytotoxicity of both compounds was comparable.
Duret
P
P
Laboratoire de Pharmacognosie associéau CNRS (BIOCIS), Facultéde Pharmacie, Université Paris-Sud, Châtenay-Malabry, France.
Hocquemiller
R
R
Gantier
J C
JC
Figadère
B
B
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005663:Furans / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007274:Injections, Intraperitoneal; D007783:Lactones / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C112079:isomurisolenin