Antimicrobial and antitumor activities of mycosporulone.
The conditions for optimal production of mycosporulone (1) are given. Its cytotoxic, antimicrobial, and antitumor activities are described. The biological activities of 1 were compared with those of known antibacterial, antifungal, and antitumor agents. The compound was particularly active against Pseudomonas aeruginosa and Staphylococcus aureus (resistant to penicillin). Compound 1 was not toxic to normal human cells (MRC(5)), although it exhibited cytotoxic activity against the human tumor cell lines MDA-MB 231 and PC(3) and the murine L-1210 leukemia cell line.
Guiraud
P
P
EA-588 Environnement-Santé, Groupe pour l'Etude du Devenir des Xénobiotiques dans l'Environnement (GEDEXE), UFR Pharmacie BP138, 38043 Meylan Cedex, France.
Steiman
R
R
Seigle-Murandi
F
F
Buarque De Gusmao
N
N
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003510:Cyclohexanes / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D013141:Spiro Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D003510:Cyclohexanes; D013141:Spiro Compounds; C400135:mycosporulone