title: Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis.
abstract: Four patients with severe cystic fibrosis lung disease, anorexia and weight loss, received Megestrol Acetate (MA), as an appetite stimulant. The initial dose was 400-800 mg daily and was continued for 6-15 months. Appetite was improved, with significant weight gain in all patients and an increase in their weight for age percentile from <5% at the start of the study to approximately the 25(th) percentile after 6 months of use and improvement in quality of life. One patient discontinued MA after 6 months, and subsequently appetite and weight were depressed.
authors.affiliation: Section of Pediatric Pulmonology, Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0718, USA.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Nasr
authors.forename: M E
authors.initials: ME
authors.lastname: Hurwitz
authors.forename: R W
authors.initials: RW
authors.lastname: Brown
authors.forename: M
authors.initials: M
authors.lastname: Elghoroury
authors.forename: D
authors.initials: D
authors.lastname: Rosen
mesh_terms: D000293:Adolescent; D000855:Anorexia / Q000188:drug therapy* / Q000209:etiology; D019167:Appetite Stimulants / Q000627:therapeutic use*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D019290:Megestrol Acetate / Q000627:therapeutic use*; D015431:Weight Loss
chemical_list: D019167:Appetite Stimulants; D019290:Megestrol Acetate