A novel sesterterpenoid, nitiol, as a potent enhancer of IL-2 gene expression in a human T cell line, from the Peruvian folk medicine "Hercumpuri" (Gentianella nitida).
A novel sesterterpenoid designated as nitiol (1), possessing enhancement activity of IL-2 gene expression in a human T cell line, was isolated from the Peruvian folk medicine "Hercampuri" (Gentianella nitida). The structure was elucidated by extensive spectroscopic investigation.
Kawahara
N
N
National Institute of Health Sciences (NIHS), Tokyo, Japan.
Nozawa
M
M
Kurata
A
A
Hakamatsuka
T
T
Sekita
S
S
Satake
M
M
D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000235:genetics; D019169:Jurkat Cells / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry*; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
D007376:Interleukin-2; D012333:RNA, Messenger; D013729:Terpenes; C401231:nitiol