title: Hypothermia and the trauma patient.
abstract: Hypothermia has profound effects on every system in the body, causing an overall slowing of enzymatic reactions and reduced metabolic requirements. Hypothermic, acutely injured patients with multisystem trauma have adverse outcomes when compared with normothermic control patients. Trauma patients are inherently predisposed to hypothermia from a variety of intrinsic and iatrogenic causes. Coagulation and cardiac sequelae are the most pertinent physiological concerns. Hypothermia and coagulopathy often mandate a simplified approach to complex surgical problems. A modification of traditional classification systems of hypothermia, applicable to trauma patients is suggested. There are few controlled investigations, but clinical opinion strongly supports the active prevention of hypothermia in the acutely traumatized patient. Preventive measures are simple and inexpensive, but the active reversal of hypothermia in much more complicated, often invasive and controversial. The ideal method of rewarming is unclear but must be individualized to the patient and institution specific. An algorithm reflecting newer approaches to traumatic injury and technical advances in equipment and techniques is suggested. Conversely, hypothermia has selected clinical benefits when appropriately used in cases of trauma. Severe hypothermia has allowed remarkable survivals in the course of accidental circulatory arrest. The selective application of mild hypothermia in severe traumatic brain injury is an area with promise. Deliberate circulatory arrest with hypothermic cerebral protection has also been used for seemingly unrepairable injuries and is the focus of ongoing research.
authors.affiliation: Section of Trauma Services, Vancouver Hospital, BC. andykirk@istar.ca
authors.forename: A W
authors.initials: AW
authors.lastname: Kirkpatrick
authors.forename: R
authors.initials: R
authors.lastname: Chun
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: R K
authors.initials: RK
authors.lastname: Simons
mesh_terms: D000465:Algorithms; D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000503:physiopathology; D001831:Body Temperature / Q000502:physiology; D001930:Brain Injuries / Q000628:therapy; D006321:Heart / Q000503:physiopathology; D006324:Heart Arrest, Induced; D006801:Humans; D007035:Hypothermia / Q000145:classification / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000517:prevention & control; D009104:Multiple Trauma / Q000503:physiopathology / Q000601:surgery; D017694:Rewarming; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000503:physiopathology* / Q000601:surgery