title: A retrospective study of the relationship between childhood asthma and respiratory infection during gestation.
abstract: BACKGROUND
  Wheeze in children has been found to be associated with prior antepartum haemorrhage and raised levels of IgE in cord blood, and acute wheezing episodes are intimately linked with respiratory viral infections.
  
  
  OBJECTIVE
  To assess the relationship between maternal presentation with respiratory tract infections in pregnancy and childhood asthma, taking into account factors which could affect presentation.
  
  
  METHODS
  This was a case-control study of 200 asthmatic children, 5-16-year-old, age-matched with one control, having no recorded history of wheeze. Data on respiratory tract infections, maternal wheeze, atopy and smoking was collected from primary care records. Deprivation score was assessed according to small residential areas and subjects were equally distributed between four general practices in Plymouth, UK.
  
  
  RESULTS
  Presentation with respiratory tract infections during pregnancy was significantly associated with childhood asthma (OR 1.69, 95% confidence interval 1.05-2.77, P = 0.03). The association was marginally stronger for infections in the first trimester (OR 2.30, 95% CI 1.05-5.41, P = 0.04) and for those with cough during pregnancy (OR 2.24, 95% CI 1.23-4.22, P = 0.007). The associations remained significant after allowing for the effect of the independent variables (gender, maternal smoking, maternal wheeze, allergic rhinitis, eczema, asthma treatment in pregnancy and deprivation [Townsend] score), using multiple logistic regression analysis (ORs and 95% CIs 1.91, 1.14-3.22; 2.32, 1.01-5.34 and 2.29, 1.17-4.48, respectively). There was also an association between numbers of presentations with respiratory infections and childhood asthma (test for trend, P = 0.02).
  
  
  CONCLUSIONS
  This study has shown an association between presentation with respiratory infection during gestation and childhood asthma. The results were not affected by the other independent variable factors studied and therefore provide some evidence to support the theory that respiratory viruses may be implicated in the aetiology of asthma.
authors.affiliation: Estover Health Centre, Plymouth, UK.
authors.forename: C H
authors.initials: CH
authors.lastname: Hughes
authors.forename: R C
authors.initials: RC
authors.lastname: Jones
authors.forename: D E
authors.initials: DE
authors.lastname: Wright
authors.forename: F F
authors.initials: FF
authors.lastname: Dobbs
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000821:virology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000821:virology; D012141:Respiratory Tract Infections / Q000276:immunology* / Q000821:virology; D012189:Retrospective Studies