Terminal differentiation and left-handed Z-DNA: a review.
Nucleic acids control the expression of genes, and different conformations of DNA structure may regulate cell death. Left-handed Z-DNA, which is speculated to function as a transcriptional enhancer, may be directly influenced by the destructive effects of terminal differentiation. The nicking-denaturation of double-stranded Z-DNA could possibly initiate and enhance terminal differentiation within specific tissues.
Gagna
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CE
Department of Pathology and Laboratory Medicine, Rm #C508c, University of Medicine and Dentistry of New Jersey-Medical School, 185 S. Orange Avenue, Newark, NJ 07103, USA.
Kuo
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Hr
Lambert
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WC
D000818:Animals; D016923:Cell Death; D002454:Cell Differentiation; D004247:DNA; D005786:Gene Expression Regulation; D006801:Humans; D009691:Nucleic Acid Denaturation
D004247:DNA