title: The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling.
abstract: Recent years have seen an exponentially increasing interest in the molecular mechanisms of signal transduction. Much of the focus has been on protein tyrosine kinase-mediated signalling, while the study of protein tyrosine phosphatases has lagged behind. We predict that the phosphatases will become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the-art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in T lymphocyte activation.
authors.affiliation: Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. tmustelin@skcc.org
authors.forename: T
authors.initials: T
authors.lastname: Mustelin
authors.forename: J
authors.initials: J
authors.lastname: Brockdorff
authors.forename: L
authors.initials: L
authors.lastname: Rudbeck
authors.forename: A
authors.initials: A
authors.lastname: Gjörloff-Wingren
authors.forename: S
authors.initials: S
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Tailor
authors.forename: M
authors.initials: M
authors.lastname: Saxena
mesh_terms: D000818:Animals; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism*
chemical_list: D011948:Receptors, Antigen, T-Cell; D017027:Protein Tyrosine Phosphatases