title: Intoxication due to negative canrenone interference in digoxin drug monitoring.
abstract: Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.
authors.forename: W
authors.initials: W
authors.lastname: Steimer
authors.forename: C
authors.initials: C
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: K
authors.initials: K
authors.lastname: Emmanuilidis
mesh_terms: D000368:Aged; D002192:Canrenone / Q000097:blood*; D004077:Digoxin / Q000097:blood* / Q000506:poisoning*; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D017248:Enzyme Multiplied Immunoassay Technique; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008508:Medication Errors; D009102:Multiple Organ Failure / Q000209:etiology; D018805:Sepsis / Q000150:complications; D013148:Spironolactone / Q000097:blood*
chemical_list: D013148:Spironolactone; D004077:Digoxin; D002192:Canrenone