Comparative in vitro and in vivo effects of antioxidants.
We have investigated the effects of reactive oxygen species (ROS) in a wide variety of systems, both in vitro and in vivo, with particular attention to their genetic effects. Some of the results of these studies, as they relate to the protective effects of antioxidants, are discussed.
Anderson
D
D
BIBRA International, Carshalton, Surrey, UK.
Phillips
B J
BJ
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity; D016466:CHO Cells; D002374:Catalase / Q000737:chemistry / Q000494:pharmacology; D002869:Chromosome Aberrations; D002986:Clinical Trials as Topic; D020552:Comet Assay; D006224:Cricetinae; D005979:Glutathione Peroxidase / Q000737:chemistry; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D015162:Micronucleus Tests; D017382:Reactive Oxygen Species / Q000378:metabolism; D012854:Sister Chromatid Exchange; D013482:Superoxide Dismutase / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*; D019820:Xanthine; D014969:Xanthine Oxidase
D000975:Antioxidants; D017382:Reactive Oxygen Species; D001761:Bleomycin; D013481:Superoxides; D014810:Vitamin E; D019820:Xanthine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D001205:Ascorbic Acid