Circulating levels of soluble CD30 and other markers in colorectal cancer patients.
In a search for new biologic serum tumor markers with prognostic value we evaluated the soluble form of the CD30 (sCD30), a marker of cells producing T helper 2 (Th2)-type cytokines, interleukin-1 receptor antagonist (IL-1ra), soluble interleukin-2 receptor (sIL-2R), soluble tumor necrosis factor -type I, -type II (sTNF-R55, -75) and immunosuppressive acidic protein (IAP) in patients, with advanced colorectal cancer. The data showed that abnormal levels of sCD30 were detected in eight (80.0%) out of ten patients. In contrast, sCD30 levels were not detected in healthy volunteers. The relationship between sCD30, sIL-2R and IAP were positively correlated. In contrast, sCD30 and IL-1ra were negatively correlated. These results suggested that IL-1ra may play a role, at least in part, to inhibit CD30 release, and sCD30 appears to be a new biologic serum tumor marker of possible use in the clinical setting of cancer patients.
Iwagaki
H
H
First Department of Surgery, Okayama University Medical School, Japan.
Hizuta
A
A
Kohka
H
H
Kobashi
K
K
Nitta
Y
Y
Isozaki
H
H
Takakura
N
N
Tanaka
N
N
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D012016:Reference Values; D012795:Sialoglycoproteins / Q000097:blood
D015703:Antigens, CD; D014408:Biomarkers, Tumor; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017730:Ki-1 Antigen; D009363:Neoplasm Proteins; D015375:Receptors, Interleukin-2; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D012795:Sialoglycoproteins; C030193:immunosuppressive acidic protein