title: Relationships between the actin cytoskeleton and cell volume regulation.
abstract: The actin cytoskeleton mediates a variety of essential biological functions in cells, including division, shape changes, and movement. A number of studies have suggested that the abundant submembranous actin cytoskeleton present in the cortex of many cell types is involved in the regulation of cell volume. This relationship is supported by numerous works which document the changes in the structural organization of the actin cytoskeleton which accompany cell volume changes and the F-actin-dependence of the regulatory volume responses. In addition, other studies demonstrate structural and functional relationships between the actin cytoskeleton and the membrane transporters known to be involved in cell volume homeostasis. This review provides a summary of the current level of knowledge in this area and discusses the mechanisms which may underlie the linkage between the actin cytoskeleton and cell volume regulation.
authors.affiliation: Department of Biology, Dickinson College, Carlisle, Pennsylvania 17013, USA. henson@dickinson.edu
authors.forename: J H
authors.initials: JH
authors.lastname: Henson
mesh_terms: D000199:Actins / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D048429:Cell Size / Q000502:physiology*; D002478:Cells, Cultured; D018118:Chloride Channels / Q000378:metabolism; D003599:Cytoskeleton / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology; D012491:Salt Gland
chemical_list: D000199:Actins; D002352:Carrier Proteins; D018118:Chloride Channels