title: Expression of the transcriptional intermediary factor TIF1alpha during mouse development and in the reproductive organs.
abstract: Nuclear receptors are important regulators of development and reproduction whose action can be modulated by transcriptional intermediary factors (TIFs). In situ hybridization was used to investigate the expression pattern of the putative nuclear receptor mediator TIF1alpha during mouse embryogenesis and adult life. TIF1alpha is ubiquitously expressed until midgestation. At 12.5 gestational days, TIF1alpha is preferentially expressed in the developing central and peripheral nervous system. Differential expression persists until perinatal stages, with high expression in the brain, nasal epithelium and within proliferating regions of the kidney and teeth. In the adult, TIF1alpha expression is predominant in both the male and female gonads. Immunogold electron microscopy revealed that TIF1alpha protein is most abundant in the nuclei of male germ cells at various stages of their maturation.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP/Collège de France, Strasbourg. karen@igbmc.u-strasbg.fr
authors.forename: K
authors.initials: K
authors.lastname: Niederreither
authors.forename: E
authors.initials: E
authors.lastname: Remboutsika
authors.forename: A
authors.initials: A
authors.lastname: Gansmuller
authors.forename: R
authors.initials: R
authors.lastname: Losson
authors.forename: P
authors.initials: P
authors.lastname: Dollé
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D002467:Cell Nucleus / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D007668:Kidney / Q000502:physiology; D008297:Male; D051379:Mice; D009297:Nasal Mucosa / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D010053:Ovary / Q000196:embryology / Q000502:physiology*; D013116:Spinal Cord / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D013737:Testis / Q000196:embryology / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D014157:Transcription Factors; C093517:transcriptional intermediary factor 1