title: Structural abnormalities of chromosome 2 in benign thyroid tumors. Three new cases and review of the literature.
abstract: Here we report our cytogenetic findings on three cases of nodular goiter, all showing structural clonal abnormalities of chromosome 2. In the first case, we found a t(2;3)(q21;q27 or q28) in two nodules of the same patient. The second case revealed a t(2;20;3)(p21;q11.2;p25), and the third case showed a t(1;2)(p22;p13). When the data from the literature and the present cases are summarized, the results suggest the existence of at least three breakpoint clusters of chromosome 2 in benign thyroid tumors or hyperplasias.
authors.affiliation: Center of Human Genetics and Genetic Counseling, University of Bremen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Bol
authors.forename: G
authors.initials: G
authors.lastname: Belge
authors.forename: B
authors.initials: B
authors.lastname: Thode
authors.forename: S
authors.initials: S
authors.lastname: Bartnitzke
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
mesh_terms: D000328:Adult; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic