Computer sequence analysis of human highly conserved zinc finger modules.
We defined a sub-family of zinc finger proteins by computer analyses and comparisons of five new finger domains against protein databases. This subclass of the cysteine-cysteine/histidine-histidine motif shows additional well conserved amino acid patterns and belongs to the human kox and gli-Kruppel gene family, sharing also the same stretches of regulatory zinc finger-containing proteins of mouse and Xenopus. We particularly describe ZF6 cDNA which contains the most interesting sequence, encoding a putative multi-domain regulatory protein.
Petroni
D
D
Dept. of Biomedical Sciences and Technologies, HSR, University of Milan, Italy.
Bartolini
E
E
Chiaramonte
R
R
Ottolenghi
S
S
Comi
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000235:genetics; D016208:Databases, Factual; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014982:Xenopus laevis; D016335:Zinc Fingers / Q000235:genetics*
D018076:DNA, Complementary