title: Infrared imaging of cystoid macular edema.
abstract: BACKGROUND
  Cystoid macular edema (CME), a cause of central visual loss, is described in various pathologies. Typically, the fluorescein angiogram confirms the diagnosis and provides qualitative information as to the extent of leakage. This study was performed to investigate the features of cysts and quantify the extent of CME using non-invasive infrared imaging.
  
  
  METHODS
  Eighteen eyes of 16 successive patients with CME in association with a broad spectrum of diseases were included in the study. The diagnosis of CME was established clinically and confirmed by fluorescein angiography. Digital infrared imaging was performed with a research scanning laser ophthalmoscope with different apertures, providing direct confocal and indirect imaging modes, to discriminate superficial features from deeper ones and to emphasize sources of multiple laterally scattered light.
  
  
  RESULTS
  CME was easily detected with infrared imaging in all eyes. Confocal mode visualized the cysts themselves, while indirect mode emphasized borders. Large central cysts were detected as distinct, non-confluent structures. In addition, folds detected with infrared imaging in the macula in 12 of the 18 eyes were not always observed clinically.
  
  
  CONCLUSIONS
  Infrared imaging provides a quick and safe diagnostic tool for patients with CME. The cystoid structures are readily localized and quantified, useful for monitoring CME. Despite differences in the pathophysiology, cysts did not differ qualitatively in a variety of diseases with infrared imaging.
authors.affiliation: Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: A
authors.initials: A
authors.lastname: Remky
authors.forename: E
authors.initials: E
authors.lastname: Beausencourt
authors.forename: M E
authors.initials: ME
authors.lastname: Hartnett
authors.forename: C L
authors.initials: CL
authors.lastname: Trempe
authors.forename: O
authors.initials: O
authors.lastname: Arend
authors.forename: A E
authors.initials: AE
authors.lastname: Elsner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007259:Infrared Rays; D007834:Lasers; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods*