Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume.
Rats were trained on an operant task and then received striatal lesions and grafts. Grafts were derived either from whole-ganglionic eminences or restricted to the lateral eminence. When retested 4 months later; graft-associated behavioural recovery was only apparent with extensive retesting. There was no difference in performance between rats that received whole-dissection or lateral-dissection grafts, and no correlation between performance and the amount of striatal-like (P-zone) tissue within the graft. It is suggested that P-zone reconstruction may be necessary, but not sufficient for behavioural recovery, which may additionally depend upon rehabilitative training.
Brasted
P J
PJ
MRC Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK.
Watts
C
C
Torres
E M
EM
Robbins
T W
TW
Dunnett
S B
SB
D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology* / Q000637:transplantation*; D016332:Fetal Tissue Transplantation; D007839:Functional Laterality; D007858:Learning / Q000502:physiology*; D008297:Male; D051381:Rats; D011930:Reaction Time; D013997:Time Factors