title: Primary pulmonary hypertension in cirrhosis of liver.
abstract: BACKGROUND
  Primary pulmonary hypertension (PPH) is a grave association of portal hypertension, and is potentially fatal in liver transplant candidates.
  
  
  OBJECTIVE
  To investigate the prevalence of PPH among cirrhotics with portal hypertension.
  
  
  METHODS
  43 cirrhotics with portal hypertension (Child B 22, C 14), after screening for cardiopulmonary diseases, were evaluated by hemodynamic study.
  
  
  RESULTS
  PPH was detected in 2 cases (4.7%), both in Child B, hepatitis B and C viruses being the etiologies. Neither had portal axis thrombosis. Two other cases also had pulmonary hypertension, but with high pulmonary capillary wedge pressure (PCWP). The 41 cases without and 2 cases with PPH had, respectively, mean pulmonary artery pressure (MPAP) 16.3 (5.9) mmHg, 26 mmHg and 33 mmHg; PCWP 11.5 (6.7) mmHg, 12 mmHg and 11 mmHg; transpulmonary pressure gradient 4.8 (2.6) mmHg (n = 27), 14 mmHg and 22 mmHg; and pulmonary vascular resistance 80.2 (55.8) dyne.sec.cm-5 (n = 27), 155.6 dyne.sec.cm-5 and 366.7 dyne.sec.cm-5. No correlation of MPAP was found with either Child-Pugh scoring (r2 = 0.0347) or with hepatic venous pressure gradient (r2 = 0.0021).
  
  
  CONCLUSIONS
  PPH has a prevalence of 4.7% among cirrhotics with portal hypertension; it bears no relation with severity of liver disease.
authors.affiliation: Department of Medicine, Institute of Post Graduate Medical Education and Research, Calcutta.
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: P K
authors.initials: PK
authors.lastname: Biswas
authors.forename: J
authors.initials: J
authors.lastname: Biswas
authors.forename: T K
authors.initials: TK
authors.lastname: Das
authors.forename: B K
authors.initials: BK
authors.lastname: De
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology*; D006976:Hypertension, Pulmonary / Q000453:epidemiology / Q000209:etiology*; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure