The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality.
We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17-2.13 and RR = 2.12; 95% CI = 1.11-4.05, respectively). Women with a family history seemed to be more susceptible to the detrimental effects of smoking; not to the effects of other risk factors. We found no effect modification by family history in men.
Boer
J M
JM
Department of Chronic Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Feskens
E J
EJ
Verschuren
W M
WM
Seidell
J C
JC
Kromhout
D
D
D000328:Adult; D001835:Body Weight; D003327:Coronary Disease / Q000401:mortality*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking