Left bronchial isomerism, normal atrial arrangement and bronchomalacia mimicking asthma: a new syndrome?
Three children who presented with steroid-resistant airflow obstruction are described. They all had bronchomalacia in the setting of a rare visceral arrangement, namely left bronchial isomerism with normal atrial arrangement. Imaging and, in two cases, a normal residual volume in the face of severe airflow obstruction were diagnostic pointers to a nonasthmatic cause of wheeze. Although the association of these abnormalities may be coincidental, together they may constitute a new clinical syndrome.
Bush
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Dept of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK.
D000015:Abnormalities, Multiple / Q000175:diagnosis*; D001249:Asthma / Q000151:congenital* / Q000175:diagnosis; D001980:Bronchi / Q000002:abnormalities*; D001982:Bronchial Diseases / Q000151:congenital* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006325:Heart Atria / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D013577:Syndrome