Biphenotypic hematological malignancy with T-lymphoid and myeloid differentiation: association with t(3;12)(p25;q24.3). Case report and review of the literature.
Biphenotypic hematological malignancies of T-lymphoid and myeloid differentiation are relatively rare and have most commonly been associated with t(8;13). However, this entity is invariably associated with eosinophilia and generally progresses to acute leukemia within a year of diagnosis. We describe a case of a biphenotypic hematological malignancy with T-lymphoid and myeloid differentiation without associated eosinophilia; however, there was an association with t(3;12)(p25;q24.3) as a sole abnormality and progression to acute leukemia within 10 months of presentation. This association with such a malignancy has not previously been described. Additional cases need to be accrued to determine the prognostic significance and clinical implications of such an association.
Dunphy
C H
CH
Department of Pathology, St. Louis University Health Sciences Center, MO, USA.
Batanian
J R
JR
D014408:Biomarkers, Tumor; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D019337:Hematologic Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor