title: Neuromyotonia, myocloni, sensory neuropathy and cerebellar symptoms in a patient with antibodies to neuronal nucleoproteins (anti-Hu-antibodies).
abstract: A middle-aged patient presented with subacute muscular stiffness, myocloni of both extremity and facial muscles, gait ataxia and symmetrical distal painful paraesthesias. Electrophysiologically, neuromyotonia was confirmed. High titer anti-Hu antibodies were detected, but no other paraneoplastic antibodies were found. Small-cell lung cancer was diagnosed. Under chemotherapy tumor remission was achieved and, except for minor sensory deficits, neurological symptoms disappeared. This report shows that paraneoplastic syndromes associated with antibodies to neuronal nucleoproteins (anti-Hu antibodies) may be associated with a syndrome including neuromyotonia, sensory neuropathy, cerebellar symptoms and myocloni.
authors.affiliation: Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-University of Munich, Germany. toepfer@fbs.med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Toepfer
authors.forename: M
authors.initials: M
authors.lastname: Schroeder
authors.forename: J W
authors.initials: JW
authors.lastname: Unger
authors.forename: H
authors.initials: H
authors.lastname: Lochmüller
authors.forename: D
authors.initials: D
authors.lastname: Pongratz
authors.forename: W
authors.initials: W
authors.lastname: Müller-Felber
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D051959:ELAV Proteins; D020234:Gait Ataxia / Q000276:immunology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000276:immunology; D009222:Myotonia / Q000276:immunology; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000276:immunology*; D011115:Polyneuropathies / Q000276:immunology; D016601:RNA-Binding Proteins / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D000912:Antibodies, Neoplasm; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins