title: Serologic evidence of heparin sensitization in cancer patients receiving heparin flushes of venous access devices.
abstract: Cancer patients with venous access devices (VADs) often receive daily flushes of heparin. Even this relatively small heparin exposure has been reported to induce immune-mediated thrombocytopenia. To estimate how frequently this occurs we tested for heparin-related antibodies in 49 patients receiving daily heparin flushes of their VADs. Although one-third of the patients showed evidence of heparin sensitization on at least one occasion during their surveillance, their antibody titers were generally low and typical of those found in other cohorts of patients who become sensitized to heparin but do not develop secondary thrombocytopenia. However, one patient developed a positive serotonin release assay indicative of a more significant sensitization, but without thrombocytopenia. Therefore, our observations suggest that heparin-induced thrombocytopenia (HIT) related to heparin flushes of VADs is uncommon but still an important diagnosis to entertain.
authors.affiliation: Hematology Service, Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Mayo
authors.forename: A M
authors.initials: AM
authors.lastname: Cullinane
authors.forename: P K
authors.initials: PK
authors.lastname: Merryman
authors.forename: M K
authors.initials: MK
authors.lastname: Horne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D002408:Catheters, Indwelling; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D010976:Platelet Count; D011159:Population Surveillance; D012701:Serotonin / Q000378:metabolism; D013921:Thrombocytopenia / Q000139:chemically induced / Q000276:immunology
chemical_list: D000906:Antibodies; D000925:Anticoagulants; D012701:Serotonin; D006493:Heparin