title: Epithelial cell proliferation activity of the biliary ductal system with congenital biliary malformations.
abstract: Congenital biliary malformations such as anomalous arrangement of the pancreaticobiliary ductal system (AAPB), congenital cystic dilatation of the common bile duct (CCDB), and congenital biliary strictures at the hepatic hilum (CBSH) are newly designated disease entities and are frequently found in adult patients with biliary malignancy such as gallbladder carcinoma, common bile duct carcinoma, and intrahepatic bile duct carcinoma. In the present study, the relationship of these malformations and biliary malignancy was investigated. We studied 61 gallbladders of patients with AAPB and 56 gallbladders of patients without AAPB; 16 common bile ducts of patients with CCDB (12 with AAPB and 4 without AAPB) and 11 gallbladders of patients without CCDB; and 17 intrahepatic bile ducts of patients with CBSH and 6 intrahepatic bile ducts of patients without CBSH. Tissue sections from the mucosa of the gallbladder, common bile duct, and intrahepatic bile duct were stained for proliferating cell nuclear antigen (PCNA). The PCNA labeling indexes of patients with these malformations were significantly higher than those of patients without these malformations (P < 0.05). Cell proliferation of the epithelia in the biliary ductal system in patients with these congenital biliary malformations was accelerated. Consequently, these congenital malformations appear to be an important risk factor for the occurrence of biliary malignancy.
authors.affiliation: Department of Surgery, Yamanashi Medical University, 1110 Shimokato, Tamaho, Nakakoma, Yamanashi 409-3821, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: R
authors.initials: R
authors.lastname: Tang
authors.forename: K
authors.initials: K
authors.lastname: Kunitomo
authors.forename: J
authors.initials: J
authors.lastname: Itakura
authors.forename: M
authors.initials: M
authors.lastname: Mogaki
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Suda
authors.forename: B
authors.initials: B
authors.lastname: Nobukawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001652:Bile Ducts / Q000002:abnormalities*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D003135:Common Bile Duct / Q000473:pathology*; D046508:Culture Techniques; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005704:Gallbladder / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D018570:Risk Assessment; D012680:Sensitivity and Specificity