A novel method to highly versatile monomeric PNA building blocks by multi component reactions.
A novel approach to monomeric PNA building blocks by a solution phase Ugi multi component reaction (MCR) is described. The reaction is easily performed in 96 well plates. The products precipitate from the reaction solution and are thus obtained in high yields and purity. Those products are not amenable by another multi step synthesis in such a diversity.
Dömling
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Morphochem AG, Martinsried, Germany. alexander.doemling@morphochem.de
Chi
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KZ
Barrère
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D000588:Amines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*
D000588:Amines; D020135:Peptide Nucleic Acids