title: Prevalence of visible disruption of cervical epithelium and cervical ectopy in African women using Depo-Provera.
abstract: Associations between Depo-Provera (injectable, progesterone-only contraceptive) use and visible disruption of cervical epithelium and cervical ectopy were investigated using data collected as part of a cervical cancer screening study in periurban Cape Town, South Africa. Women were interviewed about their contraceptive use, and underwent a gynecologic examination that included two 35-mm photographs of the cervix after application of 5% acetic acid. Photographs of 723 subjects were reviewed (blind to clinical information and using systematic criteria developed before review) for evidence of atrophy and epithelial disruption, including inflammation and ulceration. The percentage of the cervix covered with columnar epithelium (ectopy) was also estimated from the photographs. A random sample of 85 photographs was reviewed again for reliability. A total of 121 current users of Depo-Provera were no more likely to have evidence of epithelial disruption (38%) than 574 nonusers (39%), odds ratio (OR) = 1.37, 95% CI: 0.89-2.11 adjusting for age and parity. The prevalence of significant ectopy (columnar epithelium covering > 10% of the cervix) was also no different among current Depo-Provera users (OR = 1.22, 95% CI: 0.80-1.86 adjusting for age and parity). Reliability of visual scoring of epithelial disruption and ectopy was excellent (kappa = 0.8). Although the underlying prevalence of visible disruption of cervical epithelium was very high, current use of Depo-Provera was not associated with increased prevalence of visible disruption of the cervical epithelium or with ectopy in this sample of African women.
authors.affiliation: Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. lk24@columbia.edu
authors.forename: L
authors.initials: L
authors.lastname: Kuhn
authors.forename: L
authors.initials: L
authors.lastname: Denny
authors.forename: A E
authors.initials: AE
authors.lastname: Pollack
authors.forename: T C
authors.initials: TC
authors.lastname: Wright
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001284:Atrophy; D002584:Cervix Uteri / Q000473:pathology*; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects*; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D013019:South Africa; D014456:Ulcer; D002577:Uterine Cervical Diseases / Q000139:chemically induced* / Q000473:pathology; D002575:Uterine Cervicitis / Q000139:chemically induced
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate