Mammalian neural induction and brain pattern formation.
In summary, as I mentioned, I have long be focusing on the cerebellum. I first talked about the IP3 receptor in relation to the Purkinje cells. Ca2+ release through IP3 receptor regulates the fertilization, cell division, and dorso-ventral axis formation. It is also involved in learning and memory system. Gene called Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is one of the genes important in cerebellar pattern formation. Zic2 is essential in making our brain. Zic3 is important in the right and left axis formation. Purkinje cell and granule cell positioning are really nicely determined. But we now have two genes that determine the positioning, that may help to form a very nice and beautiful structure of the cerebellum. The principles and evidences obtained through the study of the cerebellum are found to be applied to other part of the brain, presumably because the cerebellum is phylogenetically old and plays an important information processing for motor movement.
Mikoshiba
K
K
Department of Molecular Neurobiology, University of Tokyo, Japan.
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D015220:Calcium Channels / Q000172:deficiency / Q000378:metabolism; D020013:Calcium Signaling; D002524:Cerebellar Ataxia / Q000209:etiology; D002531:Cerebellum / Q000196:embryology / Q000378:metabolism; D004627:Embryonic Induction / Q000235:genetics; D004827:Epilepsy / Q000209:etiology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D051379:Mice; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency / Q000378:metabolism
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D009419:Nerve Tissue Proteins; D018160:Receptors, Cytoplasmic and Nuclear