title: High-frequency pressure fluctuations measured in heart valve patients.
abstract: OBJECTIVE
  Due to the risk of thromboembolic complications, mechanical heart valve patients require life-long anticoagulant therapy, in contrast to bioprosthetic valves. The reason for this is still not fully understood. In vitro studies have demonstrated the presence of cavitation bubbles in the vicinity of mechanical heart valves, but not of bioprosthetic valves. When cavitation bubbles collapse, they release a significant amount of energy, which may damage the formed elements of the blood. A correlation between the presence of cavitation bubbles and high-frequency pressure oscillations has been established in vitro. Thus, the aim of this study was to measure and quantify high-frequency pressure oscillations in patients with normal, bioprosthetic or mechanical aortic valves.
  
  
  METHODS
  Measurements were performed in six patients with normal aortic valves after coronary bypass surgery, in five patients fitted with a Carpentier-Edwards pericardial bioprosthesis, and in nine patients fitted with a St. Jude Medical or CarboMedics aortic valve. High-frequency pressure fluctuations were measured intraoperatively using a hydrophone placed near the aortic annulus. The root mean square (RMS) value of the high-frequency pressure signals were calculated in the frequency range 35-150 kHz.
  
  
  RESULTS
  High-frequency pressure fluctuations, with intensities above the noise floor, were registered only in the vicinity of mechanical heart valve prostheses, and not in the vicinity of normal or bioprosthetic valves. The mean value of RMS pressure fluctuations was 0.5 Pa for normal aortic valves, 0.8 Pa for bioprosthetic valves, and 67 Pa for mechanical valves.
  
  
  CONCLUSIONS
  This study is the first to show the presence of high-frequency pressure fluctuations in patients with mechanical valves.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Skejby Sygehus, Aarhus University Hospital, Denmark.
authors.forename: P K
authors.initials: PK
authors.lastname: Paulsen
authors.forename: B K
authors.initials: BK
authors.lastname: Jensen
authors.forename: J M
authors.initials: JM
authors.lastname: Hasenkam
authors.forename: H
authors.initials: H
authors.lastname: Nygaard
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000502:physiology* / Q000601:surgery; D001705:Bioprosthesis; D001794:Blood Pressure; D004562:Electrocardiography; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011312:Pressure; D012815:Signal Processing, Computer-Assisted