The influence of low intake of n-3 fatty acids on platelets in elderly people.
A total of ten healthy elderly subjects ingested one capsule of 600 mg (corresponding to 150 mg docosahexaenoic acid and 30 mg eicosapentaenoic acid) RO-PUFA triglycerides per day and ten others ingested one capsule of 600 mg sunflower oil as a placebo for 42 days. In the n-3 polyunsaturated fatty acids (PUFA) group, a significant decrease of systolic blood pressure was observed, as well as a trend towards a decrease in both platelet activation and basal formation of thromboxane B(2). Also, a slight but significant increase of docosahexaenoic acid was observed in the phosphatidylethanolamine fraction as well as a significant increase of vitamin E level after the n-3 PUFA intake. Moreover, the basal production of malondialdehyde significantly decreased. No modification was observed for all these parameters in the placebo group. We conclude that a small intake of n-3 PUFA decreased the oxidative stress in platelets of elderly people and could be beneficial in subjects with atherothrombotic tendencies by lowering the cell peroxide tone.
Véricel
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Institut National de la Santé et de la Recherche Médicale U. 352, Biochimie & Pharmacologie, Bât 406, INSA-Lyon, 20 Ave A. Einstein, 69621, Villeurbanne, France. evelyne.vericel@insa-lyon.fr
Calzada
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Chapuy
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Lagarde
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D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D005227:Fatty Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D010938:Plant Oils / Q000008:administration & dosage; D015539:Platelet Activation / Q000187:drug effects; D000074242:Sunflower Oil; D013929:Thromboxane B2 / Q000096:biosynthesis
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D010938:Plant Oils; D000074242:Sunflower Oil; D004281:Docosahexaenoic Acids; D008315:Malondialdehyde; D013929:Thromboxane B2; D015118:Eicosapentaenoic Acid; D005979:Glutathione Peroxidase