title: Aspiration pneumonia in pediatric age group: etiology, predisposing factors and clinical outcome.
abstract: BACKGROUND
  Aspiration pneumonia in children is an important disease in terms of the morbidity and mortality associated with it. The objective of this study is to characterize the cases of aspiration pneumonia on the basis of the predisposing factors, types of aspiration syndromes, materials aspirated and their clinical outcome.
  
  
  METHODS
  A total of 107 patients diagnosed as having aspiration pneumonia, were included in this study. Cases were between 0-15 years of age, admitted to the Aga Khan University Hospital (AKUH) over five years.
  
  
  RESULTS
  The most common form of aspiration syndrome seen was chemical pneumonitis (52.1%). The three most common factors predisposing to pulmonary aspiration were accidental ingestion (37.4%), altered consciousness (34.6%) and neurologic disorders (29%). Children who aspirated oropharyngeal flora were at higher odds to require mechanical ventilation than those aspirating inert fluids and particulate matter (OR = 6.4, 95% CI: 1.5-29.2, p = 0.003). Milk (31.8%), kerosene (21.5%) and oral secretions (19.6%) were the most common materials aspirated. Betel nuts were the most commonly aspirated foreign body. Patients aspirating oral secretions and milk were seen to have a relatively worse clinical outcome than those aspirating kerosene oil.
  
  
  CONCLUSIONS
  Aspiration pneumonia is a relatively uncommon clinical entity at AKUH in children. However, it does cause significant morbidity and mortality.
authors.affiliation: Aga Khan University Medical College, Aga Khan University Hospital, Karachi.
authors.forename: R M
authors.initials: RM
authors.lastname: Karim
authors.forename: I A
authors.initials: IA
authors.lastname: Momin
authors.forename: I I
authors.initials: II
authors.lastname: Lalani
authors.forename: S S
authors.initials: SS
authors.lastname: Merchant
authors.forename: A A
authors.initials: AA
authors.lastname: Sewani
authors.forename: B S
authors.initials: BS
authors.lastname: Hassan
authors.forename: N
authors.initials: N
authors.lastname: Mahmood
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D015984:Causality; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D011015:Pneumonia, Aspiration / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome