title: Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors.
abstract: A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.
authors.affiliation: Life Sciences Division, Korea Institute of Science and Technology, Seoul.
authors.forename: K I
authors.initials: KI
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Cha
authors.forename: Y S
authors.initials: YS
authors.lastname: Cho
authors.forename: A N
authors.initials: AN
authors.lastname: Pae
authors.forename: C
authors.initials: C
authors.lastname: Jin
authors.forename: J
authors.initials: J
authors.lastname: Yook
authors.forename: H G
authors.initials: HG
authors.lastname: Cheon
authors.forename: D
authors.initials: D
authors.lastname: Jeong
authors.forename: J Y
authors.initials: JY
authors.lastname: Kong
authors.forename: H Y
authors.initials: HY
authors.lastname: Koh
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001392:Azocines; D001667:Binding, Competitive; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D019832:N-Methylscopolamine / Q000737:chemistry; D011485:Protein Binding; D011807:Quinolizines; D011950:Receptors, Cholinergic / Q000737:chemistry*; D011976:Receptors, Muscarinic / Q000737:chemistry; D011978:Receptors, Nicotinic / Q000737:chemistry; D000093843:Quinolizidine Alkaloids
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D001392:Azocines; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007555:Isoxazoles; D019832:N-Methylscopolamine; D011807:Quinolizines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; C004712:cytisine; D000093843:Quinolizidine Alkaloids