Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors.
A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.
Choi
K I
KI
Life Sciences Division, Korea Institute of Science and Technology, Seoul.
Cha
J H
JH
Cho
Y S
YS
Pae
A N
AN
Jin
C
C
Yook
J
J
Cheon
H G
HG
Jeong
D
D
Kong
J Y
JY
Koh
H Y
HY
D000470:Alkaloids / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001392:Azocines; D001667:Binding, Competitive; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D007555:Isoxazoles / Q000737:chemistry*; D015394:Molecular Structure; D019832:N-Methylscopolamine / Q000737:chemistry; D011485:Protein Binding; D011807:Quinolizines; D011950:Receptors, Cholinergic / Q000737:chemistry*; D011976:Receptors, Muscarinic / Q000737:chemistry; D011978:Receptors, Nicotinic / Q000737:chemistry; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001372:Aza Compounds; D001392:Azocines; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007555:Isoxazoles; D019832:N-Methylscopolamine; D011807:Quinolizines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; C004712:cytisine; D000093843:Quinolizidine Alkaloids