title: Implications of body fat distribution in an older twin population.
abstract: BACKGROUND
  As people age, fat becomes preferentially deposited in the abdominal region over the periphery, and such changes are thought to be associated with adverse metabolic outcomes. We were interested in whether body mass index (BMI) and waist-hip ratio (WHR) are differentially associated with fasting insulin levels, triglycerides, and blood pressure (systolic and diastolic) in an older population. We were also interested in whether these associations change after controlling for genetic influences.
  
  
  METHODS
  Data were obtained as part of the Swedish Adoption/Twin Study of Aging. All blood samples and anthropometric measures were assessed from 1989-1991 except insulin, which was assessed from 1986-1988. The sample contains 263 twin pairs (97 monozygotic and 166 dizygotic), 56% women, average age 65 years.
  
  
  RESULTS
  In men and women, WHR and BMI were significantly associated with all the metabolic variables except for diastolic blood pressure. When BMI's association with the metabolic variables was assessed independent of WHR, it remained significantly associated with all metabolic variables except diastolic blood pressure in men and triglycerides in women. When WHR's association with the metabolic variables was assessed independent of BMI, it did not remain significantly associated with any of the metabolic variables in men and remained significantly associated with insulin and diastolic pressure in women. After controlling for genetic effects, the relationship between WHR and the metabolic variables became nonsignificant. However, BMI remained significantly associated with systolic blood pressure and triglycerides in men, independent of WHR.
  
  
  CONCLUSIONS
  The results suggest that overall body fat is important to consider in relation to these metabolic parameters in older individuals. The results also suggest that BMI may share associations with blood pressure and triglycerides beyond those that can be attributed to familial influences.
authors.affiliation: Department of Biobehavioral Health, Pennsylvania State University, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Nelson
authors.forename: G P
authors.initials: GP
authors.lastname: Vogler
authors.forename: N L
authors.initials: NL
authors.lastname: Pedersen
authors.forename: Y
authors.initials: Y
authors.lastname: Hong
mesh_terms: D000273:Adipose Tissue / Q000502:physiology*; D000300:Adoption; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001824:Body Constitution; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D007328:Insulin; D014280:Triglycerides