title: Root canal anatomy of anterior and premolar teeth in Down's syndrome.
abstract: OBJECTIVE
  The aim of this study was to examine tooth length and root canal anatomy of 281 anterior and premolar teeth from 66 DS individuals using a standard protocol.
  
  
  RESULTS
  The results indicated that root canals in DS are relatively simple and that there is a significant reduction in root and crown length.
  
  
  CONCLUSIONS
  We propose that these observations are commensurate with the suggestion that trisomy 21 exerts its effect by slowing the mitotic cycle and rate of cell proliferation, resulting in generalized retardation of growth.
authors.affiliation: School of Dentistry, Department of Oral Sciences and Orthodontics, University of Otago, Dunedin, New Zealand.
authors.forename: A E
authors.initials: AE
authors.lastname: Kelsen
authors.forename: R M
authors.initials: RM
authors.lastname: Love
authors.forename: J A
authors.initials: JA
authors.lastname: Kieser
authors.forename: P
authors.initials: P
authors.lastname: Herbison
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003786:Dental Pulp Cavity / Q000254:growth & development / Q000473:pathology*; D004314:Down Syndrome / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009811:Odontometry; D012016:Reference Values; D019228:Tooth Crown / Q000254:growth & development / Q000473:pathology*; D014092:Tooth Root / Q000254:growth & development / Q000473:pathology*