title: Carcinosarcoma of the ampulla of Vater: a case report with immunohistochemical and ultrastructural studies.
abstract: Carcinosarcoma of the duodenum has not been reported previously, although this type of tumor has been detected in other organs. We present here a case of carcinosarcoma of the duodenum, including immunohistochemical and electron microscopical findings. An ulcerating tumor, located in the duodenal ampullary region, contained two divergent components: ordinary differentiated tubular adenocarcinoma, and sarcomatoid tissue composed of spindle tumor cells. Immunohistochemically, the adenocarcinoma cells were stained with antibodies against epithelial markers including keratin and CA19-9. In contrast, the sarcomatoid tissue was strongly positive for vimentin and was focally positive for myoglobin, keratin, and CA19-9. We speculate that the sarcomatoid element of the carcinosarcoma arose from part of the ordinary adenocarcinoma tissue.
authors.affiliation: Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kijima
authors.forename: T
authors.initials: T
authors.lastname: Takeshita
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tanahashi
authors.forename: A
authors.initials: A
authors.lastname: Suto
authors.forename: H
authors.initials: H
authors.lastname: Izumika
authors.forename: H
authors.initials: H
authors.lastname: Miki
authors.forename: Y
authors.initials: Y
authors.lastname: Terasaki
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Tamaoki
authors.forename: H
authors.initials: H
authors.lastname: Omiya
mesh_terms: D014670:Ampulla of Vater; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000175:diagnosis* / Q000648:ultrastructure; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor