title: Neurogenesis in the neocortex of adult primates.
abstract: In primates, prefrontal, inferior temporal, and posterior parietal cortex are important for cognitive function. It is shown that in adult macaques, new neurons are added to these three neocortical association areas, but not to a primary sensory area (striate cortex). The new neurons appeared to originate in the subventricular zone and to migrate through the white matter to the neocortex, where they extended axons. These new neurons, which are continually added in adulthood, may play a role in the functions of association neocortex.
authors.affiliation: Department of Psychology, Princeton University, Princeton, NJ 08544, USA. goulde@princeton.edu
authors.forename: E
authors.initials: E
authors.lastname: Gould
authors.forename: A J
authors.initials: AJ
authors.lastname: Reeves
authors.forename: M S
authors.initials: MS
authors.lastname: Graziano
authors.forename: C G
authors.initials: CG
authors.lastname: Gross
mesh_terms: D000375:Aging; D000818:Animals; D001253:Astrocytes / Q000166:cytology; D001369:Axons / Q000648:ultrastructure; D001973:Bromodeoxyuridine; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D002470:Cell Survival; D005260:Female; D020547:Lateral Ventricles / Q000166:cytology; D008252:Macaca fascicularis; D008297:Male; D018613:Microscopy, Confocal; D019579:Neocortex / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D010296:Parietal Lobe / Q000166:cytology* / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology* / Q000502:physiology; D013702:Temporal Lobe / Q000166:cytology* / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology
chemical_list: D001973:Bromodeoxyuridine