Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines.
A series of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo[3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.
Yum
E K
EK
Korea Research Institute of Chemical Technology, Yusung, Taejon.
Kang
S K
SK
Kim
S S
SS
Choi
J K
JK
Cheon
H G
HG
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D015394:Molecular Structure; D054328:Proton Pump Inhibitors; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors; D011804:Quinolines; D000431:Ethanol