Kawasaki syndrome-like illness associated with infection caused by enterotoxin B-secreting Staphylococcus aureus.
Two children had symptoms and clinical signs that were characteristic of the diagnostic criteria for Kawasaki syndrome, temporally associated with Staphylococcus aureus bacteremia. One child initially had focal osteomyelitis that was evident clinically and radiographically, and radiographic evidence of multifocal osteomyelitis was noted at follow-up. The blood-borne S. aureus isolates from these two patients secreted staphylococcal enterotoxin B and were negative for toxic shock syndrome toxin. Staphylococcal and streptococcal superantigens may play a role in the pathogenesis of some cases of Kawasaki syndrome or Kawasaki syndrome-like illness.
Hall
M
M
Department of Pediatrics, The University of Texas Health Science Center at San Antonio, 78284-7811, USA.
Hoyt
L
L
Ferrieri
P
P
Schlievert
P M
PM
Jenson
H B
HB
D000900:Anti-Bacterial Agents; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004768:Enterotoxins / Q000096:biosynthesis / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy / Q000382:microbiology*; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D013203:Staphylococcal Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification* / Q000378:metabolism; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004768:Enterotoxins