Inflammation-induced cholestasis.
Inflammatory cytokines produced in response to various infectious and non-infectious stimuli are potent inducers of intrahepatic cholestasis (inflammation-induced cholestasis). The cholestatic effect of cytokines results mainly from inhibition of expression and function of hepatocellular transport systems which normally mediate hepatic uptake and biliary excretion of bile salts and various non-bile salt organic anions (e.g. bilirubin). These cytokine effects are reversible and bile secretory function is restored upon disappearance of the inflammatory injury. This review summarizes the clinical, pathophysiological and molecular aspects of inflammation-induced cholestasis.
Trauner
M
M
Department of Internal Medicine, Karl-Franzens University School of Medicine, Graz, Austria. michael.trauner@kfunigraz.ac.at
Fickert
P
P
Stauber
R E
RE
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D002648:Child; D002779:Cholestasis / Q000097:blood / Q000209:etiology*; D016207:Cytokines / Q000097:blood / Q000633:toxicity; D004731:Endotoxins / Q000097:blood / Q000633:toxicity; D006505:Hepatitis / Q000097:blood / Q000150:complications; D006801:Humans; D007239:Infections / Q000097:blood / Q000150:complications; D007249:Inflammation / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000150:complications; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D011183:Postoperative Complications
D016207:Cytokines; D004731:Endotoxins