[Assessment of genotoxicity and late effects of radiation and chemical exposures].
The 3-month-old female rats received with drinking water PbCl2 or Hg2(NO3)2 in concentrations 100 or 1 mkg/l in account to metal, respectively, during 1 month before and 1 month after single gamma-irradiation with 25 or 50 cGy doses. The features of action of lead- and mercury-ions revealed in combination with low doses radiation. In case of the mercury ions introduction the relationships had been shown between early postradiation biochemical effects (changes of blood leucocyte DNA indexes) and blood granulocyte changes in 1 month after irradiation, and correlation of postradiation repair results with life span shortening as well.
Ivanov
S D
SD
Central Research Institute of Roentgenology and Radiology, St.-Petersburg. sdivanov@radar.spb.ru
Kovan'ko
E G
EG
Popovich
I G
IG
Zabezhinskiĭ
M A
MA
D000818:Animals; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects*; D005260:Female; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D008017:Life Expectancy; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D019216:Metals, Heavy / Q000009:adverse effects*; D009152:Mutagenicity Tests; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009504:Neutrophils / Q000187:drug effects / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D013997:Time Factors
D019216:Metals, Heavy; D004247:DNA