Donor lung pretreatment with prostaglandin E(1) does not improve lung graft preservation.
Prostaglandin E(1) (PGE(1)) is widely used to improve early graft function after lung transplantation, but some studies have questioned its benefits. Therefore we evaluated the effect of donor pretreatment with PGE(1) in our porcine model of single lung transplantation. Donors received PGE(1) or placebo intravenously before flushing the pulmonary artery with modified Euro-Collins solution. After cold storage, the excised left lung was transplanted. Ischemic time was 4 h. We used our right side heart bypass model to measure standardized pulmonary vascular resistance and to study blood flow distribution between recipient's native and transplanted lung. Systemic and pulmonary hemodynamics and gas exchange were also measured. After transplantation, pulmonary vascular resistance was significantly higher in the transplanted lung, which received only one fourth of the total pulmonary blood flow. PGE(1) pretreatment did not improve pulmonary hemodynamic parameters, or gas exchange.
Vainikka
T
T
Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland.
Heikkilä
L
L
Kukkonen
S
S
Toivonen
H
H
Verkkala
K
K
Mattila
S
S
D000527:Alprostadil / Q000627:therapeutic use*; D000818:Animals; D015925:Cryopreservation; D006439:Hemodynamics / Q000187:drug effects; D008168:Lung / Q000187:drug effects*; D016040:Lung Transplantation; D011292:Premedication; D011652:Pulmonary Circulation / Q000187:drug effects; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D013552:Swine; D014019:Tissue Donors; D014655:Vascular Resistance / Q000187:drug effects
D000527:Alprostadil