Bioactivities of chalcones.
This review outlines the different bioactivities of a variety of chalcones. The cytotoxic, anticancer, chemopreventative and mutagenic properties of a number of chalcones are described followed by an account of various of these unsaturated ketones as antimicrobial agents. The antiviral, antiprotozoal and insecticidal activities of a variety of chalcones are reviewed as well as the enzyme-inhibitory properties and miscellaneous activities of some of these molecules.
Dimmock
J R
JR
College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan, S7N 5C9, Canada. dimmock@skyway.usask.ca
Elias
D W
DW
Beazely
M A
MA
Kandepu
N M
NM
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D009153:Mutagens / Q000494:pharmacology
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009153:Mutagens; D002599:Chalcone