title: Low risk of vertical transmission of hepatitis C virus by breast milk.
abstract: To evaluate the risk of hepatitis C virus (HCV) transmission via breast milk, we collected 76 samples of breast milk from 73 chronically HCV-infected women and serum samples from their 76 perinatally HCV-exposed children. Enzyme immunoassay and strip immunoblot assay were used for detection of antibodies to HCV, and reverse transcriptase-polymerase chain reaction analysis was used for detection of HCV RNA. None of the 76 samples of breast milk contained HCV RNA, whereas 37 (59.7%) of 62 mothers tested for HCV RNA had HCV viremia. Only 1 of the 76 breast-fed infants had evidence of HCV infection. Because HCV infection in this child was detected 1 month after birth, it seems unlikely that it was transmitted by breast-feeding. These results indicate that HCV infection in pregnant women should not be a contra-indication for breast-feeding.
authors.affiliation: Institute for Medical Microbiology and Immunology, University Hospital Eppendorf, 20246 Hamburg, Germany. polywka@uke.uni-hamburg.de
authors.forename: S
authors.initials: S
authors.lastname: Polywka
authors.forename: M
authors.initials: M
authors.lastname: Schröter
authors.forename: H H
authors.initials: HH
authors.lastname: Feucht
authors.forename: B
authors.initials: B
authors.lastname: Zöllner
authors.forename: R
authors.initials: R
authors.lastname: Laufs
mesh_terms: D001942:Breast Feeding; D005260:Female; D006526:Hepatitis C / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008895:Milk, Human / Q000821:virology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012367:RNA, Viral / Q000032:analysis; D012306:Risk
chemical_list: D012367:RNA, Viral