[Disorders of energy metabolism in the rat brain under extreme exposures: a new method for assessing the energy state of the brain].
We propose a new method to evaluate energy state of the brain based on vital assay for phosphate metabolites and intracellular pH in the brain. A proposed Z-index describes a set of correlations between phosphates involved in brain energy metabolism assayed in vivo by magnetic resonance spectroscopy on 31P nuclei. We tried to use Z-index as a quantitative test for disturbed energy metabolism. Potentialities of Z-index for evaluating rat brain energy state after extreme influences (gamma [correction of X-] irradiation and postoperative shock of the brain cortex) have been demonstrated.
Samenova
N A
NA
Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Dubinskiĭ
V Z
VZ
Konradov
A A
AA
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004734:Energy Metabolism / Q000528:radiation effects*; D005625:Frontal Lobe / Q000601:surgery; D005720:Gamma Rays; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D010710:Phosphates / Q000378:metabolism / Q000528:radiation effects; D051381:Rats; D013997:Time Factors
D010710:Phosphates