title: Bleomycin-induced scleroderma: report of a case with a chronic course rather than the typical acute/subacute self-limiting form.
abstract: We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
authors.affiliation: Cattedra de Reumatologia II, Dipartimentao di Scienze Mediche, Università di Cagliari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Passiu
authors.forename: A
authors.initials: A
authors.lastname: Cauli
authors.forename: F
authors.initials: F
authors.lastname: Atzeni
authors.forename: M
authors.initials: M
authors.lastname: Aledda
authors.forename: G
authors.initials: G
authors.lastname: Dessole
authors.forename: G
authors.initials: G
authors.lastname: Sanna
authors.forename: P
authors.initials: P
authors.lastname: Nurchis
authors.forename: A
authors.initials: A
authors.lastname: Vacca
authors.forename: P
authors.initials: P
authors.lastname: Garau
authors.forename: M
authors.initials: M
authors.lastname: Laudadio
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D012074:Remission Induction; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000903:Antibiotics, Antineoplastic; D001761:Bleomycin