SHORT COMMUNICATION maternal thyroid dysfunction and c- fos and c- jun expression in rat placenta.
Maternal thyroid dysfunction is associated with perturbed fetal brain development and neurological deficits in adulthood in rat and human. To investigate whether these effects occur secondary to placental dysfunction, c- fos and c- jun expression in placenta from normal (euthyroid) and moderately hypothyroid rat dams were investigated by Northern hybridization analysis. In normal placenta, c- fos expression increased by 74 per cent between 16 and 21 days of gestation (dg) whereas c- jun expression declined by 46 per cent. Moderate maternal hypothyroidism depressed placental c- fos expression by 32 per cent at 19 dg, but elevated c- fos and c- jun expression by 139 and 86 per cent, respectively, at 21 dg. Maternal hypothyroidism may therefore induce c- fos/c- jun -related placental dysfunction, but only relatively late in gestation when fetal thyroid function is already established.
Leonard
A J
AJ
Division of Molecular Endocrinology, UCL Medical School, Mortimer Street, London, W1N 8AA, UK.
Pickard
M R
MR
Sinha
A K
AK
Edwards
P R
PR
Evans
I M
IM
Ekins
R P
RP
D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D016762:Genes, fos; D016758:Genes, jun; D007037:Hypothyroidism / Q000378:metabolism*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley