Multiple red blood cell antibodies produced by donor B lymphocytes after ABO-matched allogeneic bone marrow transplantation.
A 50-year-old man with AML[M2,t(8;21)] underwent BMT from his younger sister. At that time, he had no unexpected antibody and his blood type was O(+), CcDEe. The type of Kidd was not examined. The donor's blood type was O(+), CCDee, Jk(a+b-). One year after the BMT, the patient's blood type had changed to that of the donor's and anti-E antibody was detected. Despite the use of platelet concentrates (PCs) only, anti-c antibody was later identified. We conclude that there is a need to check red cell antibodies at regular intervals, even when using PCs only, for earlier detection of unexpected antibodies after BMT.
Tasaki
T
T
Department of Clinical Pathology, Iwate Medical University, Japan. ttasaki@cap.iwate-med.ac.jp
Sasaki
S
S
Gotoh
K
K
Itoh
C
C
Itoh
S
S
Kuriya
S
S
D000017:ABO Blood-Group System / Q000276:immunology*; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000378:metabolism*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System