[The aspects of adenylate cyclase activity regulation in myocardium cell membranes during hypokinesia].
Nonstimulated and isoproterenol, GTF, GITF, NaF stimulated activities of the adenylate cyclase in sarcolemma in white rats' myocardium was studied after two weeks of hypokinesia. As was established, in restrained animals the sensitivity of adenylate cyclase to the specified agents was increased and transition to the bimodal GTF regulation took place. It is hypothesised that involvement of membrane-bound Gi-proteins in the adrenergic effects on cardiomyocytes is one of mechanisms of the cardiotropic effects of restraint and heart distresses.
Bulanova
K Ia
KIa
Komar
E S
ES
Lobanok
L M
LM
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism; D006162:Guanylate Cyclase / Q000378:metabolism; D018476:Hypokinesia / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D012508:Sarcolemma / Q000201:enzymology
D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase