The effect of Helicobacter pylori eradication therapy on gastric antral myoelectrical activity and gastric emptying in patients with non-ulcer dyspepsia.
BACKGROUND
Dysmotility of the gastroduodenal region and delayed gastric emptying have been considered to play roles in non-ulcer dyspepsia (NUD). Helicobacter pylori-induced inflammation of the gastric mucosa may affect gastric motility.


OBJECTIVE
To evaluate the effects of H. pylori eradication therapy on gastrointestinal motility and symptoms in NUD patients.


METHODS
: Forty-six NUD patients were examined for gastric emptying, antral myoelectrical activity, H. pylori infection, and symptom scores. In H. pylori-positive NUD patients, gastric emptying, antral myoelectrical activity, and symptom scores were also analysed 2 months after cure of H. pylori infection.


RESULTS
Sixty-seven per cent of NUD patients were H. pylori-positive. Both abnormal gastric emptying and antral myoelectrical activity were observed in NUD patients. H. pylori-positive NUD patients were divided into three groups according to their gastric emptying: the delayed group, the normal group, and the rapid group. In the delayed and rapid gastric emptying groups, the emptying and symptom scores were improved significantly by eradication. There was no improvement in symptom scores in the normal gastric emptying NUD group by the eradication therapy.


CONCLUSIONS
Disturbed gastric emptying and antral myoelectrical activity play roles in NUD. H. pylori-induced disturbed gastric emptying may cause some NUD symptoms. Gastric emptying and symptom scores are improved by H. pylori eradication therapy in NUD patients with disturbed gastric emptying; H. pylori eradication therapy is effective in H. pylori-positive NUD patients with disturbed gastric emptying.
Miyaji
H
H
Second Department of Internal Medicine, Fukui Medical University, Fukui, Japan.
Azuma
T
T
Ito
S
S
Abe
Y
Y
Ono
H
H
Suto
H
H
Ito
Y
Y
Yamazaki
Y
Y
Kohli
Y
Y
Kuriyama
M
M
D000082:Acetaminophen / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000097:blood; D004415:Dyspepsia / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011706:Pyloric Antrum / Q000503:physiopathology*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen