Influence of the design for fixation implants on local infection: experimental study of dynamic compression plates versus point contact fixators in rabbits.
OBJECTIVE
Comparison of infection resistance after local bacterial challenge associated with two different designs for fixation implants: the conventional dynamic compression plate (DCP) and the point contact fixator (PC-Fix).


METHODS
Randomized, prospective study in experimental animals. Grouped sequential experimental procedure. Observation time was twenty-eight days, with twenty animals per group.


METHODS
Following surgery, animals were kept without restrictions in individual hutches.


METHODS
Forty White New Zealand rabbits. Thirty-eight animals, nineteen per group, were included in the final evaluation.


METHODS
Under sterile conditions, specially manufactured titanium DCP or PC-Fix of identical dimensions were fixed to rabbit tibiae. After wound closure, different concentrations of Staphylococcus aureus, between 2 x 10(4) and 2 x 10(8) colony-forming units (CFU), were inoculated percutaneously at the implant site.


METHODS
Implants, underlying bone, and surrounding soft tissues were removed under sterile conditions and quantitatively evaluated for bacterial growth. Infection was defined as positive bacterial growth at the bone-implant interface.


RESULTS
The overall infection rate was 45 percent. The infection dose of 50 percent (ID50) was 7.08 x 10(5) CFU for the DCP group and 8.51 x 10(6) CFU for the PC-Fix group. The infection rate was 63 percent (twelve of nineteen animals) for the DCP group and 26 percent (five of nineteen animals) for the PC-Fix group. This difference was statistically significant (p = 0.022).


CONCLUSIONS
After local bacterial challenge, we found a statistically significant difference in the infection rates depending on the implant design. The higher infection resistance associated with the PC-Fix design seems to be related to the reduced contact area at the bone-implant interface.
Arens
S
S
AO ASIF Research Institute, Davos, Switzerland.
Eijer
H
H
Schlegel
U
U
Printzen
G
G
Perren
S M
SM
Hansis
M
M
D000818:Animals; D001860:Bone Plates; D004305:Dose-Response Relationship, Drug; D006622:Hip Prosthesis / Q000009:adverse effects*; D016268:Internal Fixators; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D011817:Rabbits