[The effect of astrocytoma cells on secretion of cytokines by autologous lymphocytes].
Immunotherapy is one of the experimental methods used in the treatment of brain tumours. The development of astrocytomas is accompanied by decreased activity of lymphocytes, namely inhibition of mitogen-induced proliferation and decreased cytokine secretion, which is an adverse event in the course of disease. In the present study, astrocytoma cells obtained from human tumours and cocultured with autologous lymphocytes inhibited cytokine secretion by those lymphocytes.
Kowalski
J
J
Zakładu Farmakologii Klinicznej, Slaskiej Akademii Medycznej w Katowicach.
Stachura
Z
Z
Bierzyńska-Macyszyn
G
G
Madej
A
A
Belowski
D
D
Herman
Z S
ZS
D001254:Astrocytoma / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D016207:Cytokines / Q000172:deficiency* / Q000378:metabolism*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D016207:Cytokines