title: [Adult's anaplastic CD30+ large cell lymphomas].
abstract: Anaplastic large-cell lymphomas were recognized by Stein in 1985. Less than fifteen years were necessary to confirm this entity, as well as her phenotype and to characterize the t(2;5) (p23;q35) chromosomal abnormality. This rare subgroup of non-Hodgkin's lymphomas (15% of peripheral T cell lymphomas and 8% of all diffuse aggressive lymphomas) is individualized in the Real classification. This disease, which had a bimodal age distribution, is clinically characterized by a diffuse nodal involvement and the frequency of extranodal involvement, especially skin and lungs. Primitive cutaneous anaplastic large cell lymphomas belong to the cutaneous CD30+ lymphoproliferative diseases spectrum. Among peripheral T cell and diffuse aggressive lymphomas, they have the better prognosis. We present in this paper a review of the recent advances in the knowledge, treatment and prognosis of this peculiar entity.
authors.affiliation: Service d'oncologie-radiothérapie, Clinique francheville, 38, boulevard de Vésone, 24000 Périgueux.
authors.forename: L
authors.initials: L
authors.lastname: Cany
authors.forename: P
authors.initials: P
authors.lastname: Soubeyran
authors.forename: V
authors.initials: V
authors.lastname: Boulanger
authors.forename: I
authors.initials: I
authors.lastname: Soubeyran
authors.forename: P
authors.initials: P
authors.lastname: Richaud
authors.forename: H
authors.initials: H
authors.lastname: Eghbali
authors.forename: B
authors.initials: B
authors.lastname: Hoerni
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen