title: Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement.
abstract: Molecular rearrangements of the MLL gene at the 11q23 region have been identified in most cases of infant leukemia, regardless of the phenotype. We present a case of acute myeloid leukemia which coexpressed myeloid and lymphoid markers in a 12-month-old girl. Karyotype analysis revealed the presence of a thus far unreported translocation t(10;11)(p13;p15). Although no 11q23 abnormalities were cytogenetically detectable, an MLL gene molecular rearrangement was found.
authors.affiliation: Servicio de Hematología del Hospital Universitario Marqués de Valdecilla, Santander, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Marco
authors.forename: E
authors.initials: E
authors.lastname: Bureo
authors.forename: M D
authors.initials: MD
authors.lastname: Delgado
authors.forename: C
authors.initials: C
authors.lastname: Richard
authors.forename: M A
authors.initials: MA
authors.lastname: Cuadrado
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez Retortillo
authors.forename: M
authors.initials: M
authors.lastname: Recio
authors.forename: A
authors.initials: A
authors.lastname: Zubizarreta
mesh_terms: D000208:Acute Disease; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase