title: [Genetic distances and taxonomic analysis of human populations of the Volga-Ural region based on data on DNA polymorphism].
abstract: DNA polymorphism was studied in the human diallelic loci MET and D7S23 linked to the cystic fibrosis gene, diallelic locus PAH (the phenylketonuria gene), polyallelic locus ApoB, and hypervariable DNA sequences identified by means of DNA fingerprinting with phage M13 DNA as a probe. The obtained data were used to calculate genetic distances and perform taxonomic analysis of populations of the Volga-Ural region (Turkic and Finno-Ugric ethnic groups). The DNA polymorphic systems studied were demonstrated to be highly informative; their advantages and disadvantages were revealed. According to the data obtained, the genetic distances that were calculated from DNA fingerprints more adequately reflected the genetic relationships between the populations studied than the distances calculated from the allelic frequencies of four DNA loci. It was also found that, in population studies, it would suffice to analyze only the 3.5-6 kb fingerprint fragment that is most suitable for reading, rather than the entire fingerprint obtained.
authors.affiliation: Department of Biochemistry and Cytochemistry, Ufa Research Center, Russian Academy of Sciences, Russia.
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: I M
authors.initials: IM
authors.lastname: Khidiatova
authors.forename: T V
authors.initials: TV
authors.lastname: Viktoronva
authors.forename: R I
authors.initials: RI
authors.lastname: Fatkhlislavoma
authors.forename: A R
authors.initials: AR
authors.lastname: Galeeva
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics; D002874:Chromosome Mapping; D003550:Cystic Fibrosis / Q000235:genetics; D004247:DNA / Q000235:genetics*; D016172:DNA Fingerprinting; D003710:Demography; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D010661:Phenylketonurias / Q000235:genetics; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D012426:Russia
chemical_list: D001055:Apolipoproteins B; D005819:Genetic Markers; D004247:DNA