title: Ultrasonographically guided injection of corticosteroids for the treatment of retroseptal capillary hemangiomas in infants.
abstract: OBJECTIVE
  Injection of corticosteroids is a well-documented and successful mode of treatment for periorbital capillary hemangiomas. Because of the greater potential risk involved with retrobulbar injections, no prior study has described this treatment for tumors located behind the orbital septum. Although retroseptal intraorbital capillary hemangiomas comprise only 7% of all adnexal capillary hemangiomas, complications such as optic nerve compression or astigmatism may necessitate treatment.
  
  
  METHODS
  Three patients with deep orbital hemangiomas that caused vision-threatening complications were treated with intralesional injections of triamcinolone and betamethasone. Orbital injection was performed with use of real-time ultrasonographic guidance of the needle. This technique was valuable in providing continuous, accurate, and safe advancement of the needletip in the orbit to avoid the globe and orbital walls. Ultrasonography also permitted precise placement of the needle tip within the tumor and visualization of the injected material.
  
  
  RESULTS
  Significant improvement was demonstrated in all cases on the basis of both ultrasonographic measurements and regression of clinical manifestations such as astigmatism, chemosis, proptosis, and optic nerve pallor. No complications were noted.
  
  
  CONCLUSIONS
  Intralesional injection of corticosteroids to treat retroseptal and retrobulbar capillary hemangiomas was found to be a safe and effective treatment modality in our patients. Positioning of the injecting needle was guided by ultrasonography.
authors.affiliation: Jules Stein Eye Institute, Department of Ophthalmology, University of California-Los Angeles School of Medicine, 90095, USA.
authors.forename: D
authors.initials: D
authors.lastname: Neumann
authors.forename: S J
authors.initials: SJ
authors.lastname: Isenberg
authors.forename: A L
authors.initials: AL
authors.lastname: Rosenbaum
authors.forename: R A
authors.initials: RA
authors.lastname: Goldberg
authors.forename: V H
authors.initials: VH
authors.lastname: Jotterand
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000627:therapeutic use; D001251:Astigmatism / Q000209:etiology; D001623:Betamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D003229:Conjunctival Diseases / Q000209:etiology; D004487:Edema / Q000209:etiology; D005094:Exophthalmos / Q000209:etiology; D005134:Eye Neoplasms / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D018324:Hemangioma, Capillary / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007267:Injections; D008279:Magnetic Resonance Imaging; D009901:Optic Nerve Diseases / Q000209:etiology; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage* / Q000627:therapeutic use; D014463:Ultrasonography
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D014221:Triamcinolone; D001623:Betamethasone