From global expression data to gene networks.
Allowing the parallel monitoring of the transcription of thousands of genes, microarrays constitute a powerful technique for functional genomics. In a recent paper, a clustering method and a local alignment software were combined to identify DNA motifs in sets of yeast genes endowed with similar transcription profiles throughout mitosis (1). Identifying various known transcriptional binding sites together with new putative ones, the authors made a significant step towards a systematic characterization of the regulatory structure of genomic networks. BioEssays 1999;21:895-899.
Thieffry
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Unité de Bioinformatique, IBMM-ULB, 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium. denis@dbm.ulb.ac.be
D015374:Biosensing Techniques; D002453:Cell Cycle; D003201:Computers; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D016678:Genome; D020407:Internet; D005810:Multigene Family; D015003:Yeasts
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