title: Effect of mandibular advancement splint on psycho-intellectual derangements in patients with sleep apnea syndrome.
abstract: The mandibular advancement splint (MAS) was recently introduced for the management of sleep apnea syndrome (SAS), although its effects on psycho-intellectual functions have not been elucidated yet. We examined psycho-intellectual function before and after treatment with MAS in patients with SAS. Twenty patients with SAS underwent psycho-intellectual function testing before and after treatment with MAS for 3 to 4 weeks. The apnea index significantly decreased from 19.0+/-15.6 to 2.4+/-1.9. The state anxiety score significantly decreased from 44.6+/-12.1 to 33.7+/-11.1, the trait anxiety score significantly decreased from 46.2+/-13.4 to 37.6+/-13.8, and the depression scale score significantly decreased from 39.2+/-11.0 to 30.8+/-9.9 with MAS treatment. By the Cornell Medical Index and the Yatabe-Guilford test, the patients became less neurotic and less eccentric after treatment. By the Uchida-Kraepelin psychodiagnostic test, calculation ability significantly increased from 1247.4+/-402.1 to 1950.2+/-651.9. We conclude that MAS treatment reduces apneic episodes and improves psycho-intellectual derangements in patients with SAS.
authors.affiliation: The Fourth Department of Internal Medicine, Kinki University School of Medicine, Osakasayama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nambu
authors.forename: Y
authors.initials: Y
authors.lastname: Nagasaka
authors.forename: E
authors.initials: E
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Hamada
authors.forename: M
authors.initials: M
authors.lastname: Fukuoka
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000209:etiology* / Q000523:psychology; D003863:Depression / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D019186:Mandibular Advancement / Q000295:instrumentation*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011569:Psychiatric Status Rating Scales; D012891:Sleep Apnea Syndromes / Q000097:blood / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy*; D013165:Splints; D016896:Treatment Outcome
chemical_list: D010100:Oxygen