The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains.
Two synaptic-vesicle proteins, rab3a and synaptophysin, have been studied on post-mortem brain tissues of schizophrenics and healthy controls. We found significantly reduced levels of rab3a in thalamus (p<0.001); for both proteins in gyrus cinguli and hippocampus (p<0.0001); for rab3a in frontal and parietal cortex (p<0.05); and no differences in temporal cortex or cerebellum in schizophrenics compared with controls. Reduced synaptic density may be a prominent feature of the molecular neuropathology of schizophrenia.
Davidsson
P
P
Institute of Clinical Neuroscience, Göteborg University, Sahlgrenska University Hospital/Mölndal, Mölndal, Sweden. pia.davidsson@ms.se
Gottfries
J
J
Bogdanovic
N
N
Ekman
R
R
Karlsson
I
I
Gottfries
C G
CG
Blennow
K
K
D000328:Adult; D000368:Aged; D015415:Biomarkers; D015153:Blotting, Western; D002531:Cerebellum / Q000737:chemistry* / Q000378:metabolism; D002540:Cerebral Cortex / Q000737:chemistry* / Q000378:metabolism; D005089:Exocytosis / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000737:chemistry* / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012559:Schizophrenia / Q000378:metabolism; D013572:Synaptic Vesicles / Q000737:chemistry* / Q000378:metabolism; D016708:Synaptophysin / Q000032:analysis* / Q000378:metabolism; D013788:Thalamus / Q000737:chemistry* / Q000378:metabolism; D020826:rab3A GTP-Binding Protein / Q000032:analysis* / Q000378:metabolism
D015415:Biomarkers; D016708:Synaptophysin; D020826:rab3A GTP-Binding Protein