title: Vasoactive effects of potassium in kidneys of hypertensive rats fed a high-potassium diet.
abstract: METHODS
  Levels of dietary and serum potassium are thought to correlate inversely with vascular resistance and blood pressure. This study examined renal vascular resistance in perfused rat kidneys partially preconstricted with 10 micromol/ phenylephrine, quantifying changes in the resistance when levels of potassium in the perfusate ([K+]o) were varied between 2 and 80 mmol/l.
  
  
  RESULTS
  In kidneys from 17-week-old Wistar-Kyoto rats (WKY strain) fed a normal diet (American Institute of Nutrition AIN-76 diet), the resistance decreased when [K+]o was raised from 4 to 6-20 mmol/l, whereas resistance increased when [K+]o was either lowered to 2 mmol/l or raised above 25 mmol/l. The vasodilation that occurred at 13 mmol/l [K+]o was blocked by 100 micromol/l BaCl2 and 10 micromol/l ouabain in an additive manner, suggesting that both the inward rectifier K+ channel and the Na-K-ATPase underlie the dilation. Kidneys from spontaneously hypertensive rats (SHR strain) fed the AIN-76 diet displayed modestly enhanced vasodilations and vasoconstrictions as compared to WKY. A high-potassium diet (AIN-76 supplemented with 3.5% potassium citrate, provided for 8 weeks) led to exaggerated vasoconstrictive effects of [K+]o, and modestly enhanced vasodilations, in WKY rats. In contrast, the diet led to attenuated vasoconstrictions, and dramatically enhanced vasodilations, in the SHR strain. The diet did not affect the blood pressure increase or weight gain of either strain.
  
  
  CONCLUSIONS
  Changes in the responsiveness of blood vessels to extracellular potassium might underlie some beneficial effects of high-potassium diets in hypertensive individuals.
authors.affiliation: Department of Pharmacology and Neuroscience, The Albany Medical College, New York, USA. murph033@mc.duke.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Murphy
authors.forename: D B
authors.initials: DB
authors.lastname: Cohen
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D017419:Potassium, Dietary / Q000008:administration & dosage*; D051381:Rats; D011921:Rats, Inbred WKY; D012079:Renal Circulation / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D017419:Potassium, Dietary