title: [Beta-catenin mutations in a common skin cancer: pilomatricoma].
abstract: The normal hair development requires WNT signalling pathways. A constitutive activation of beta-catenin, one of the components of this cascade, induces an abnormal proliferation of hair matrix cells. This activation is observed in a human skin tumours called pilomatricoma. Mutations of the beta-catenin gene are detected in 75% of the tumours analysed.
authors.affiliation: Laboratoire de dermatologie moléculaire, Institut universitaire de recherche clinique, 641, avenue du Doyen-Giraud, 34093 Montpellier Cedex 5.
authors.forename: M
authors.initials: M
authors.lastname: Durand
authors.forename: J P
authors.initials: JP
authors.lastname: Molès
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D006201:Hair Diseases / Q000235:genetics*; D006801:Humans; D009154:Mutation; D018296:Pilomatrixoma / Q000235:genetics*; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000235:genetics*; D015534:Trans-Activators; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin