title: Synthesis and some reactions of 2-acetylimidazo[4,5-b]pyridine. Antituberculotic activity of the obtained compounds.
abstract: 2-Acetylimidazo[4,5-b]pyridine was prepared and its reactions with some aromatic amines and sulfur (Willgerodt-Kindler reaction), some aromatic aldehydes, some carboxylic acid hydrazides as well as thiourea were investigated. New imidazo[4,5-b]pyridine derivatives with different substituents in 2-position (N-arylthioamides, imines, alpha, beta-unsaturated ketones, hydrazido-hydrazones and aminothiazole) were obtained. Most of the synthesized compounds were tested in vitro for their antituberculotic activity.
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Bukowski
authors.forename: M
authors.initials: M
authors.lastname: Janowiec
authors.forename: Z
authors.initials: Z
authors.lastname: Zwolska-Kwiek
authors.forename: Z
authors.initials: Z
authors.lastname: Andrzejczyk
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C400590:2-acetylimidazo(4,5-b)pyridine; D000995:Antitubercular Agents; D007093:Imidazoles; D011725:Pyridines