title: Multiple osteolysis of peripheral extremities in a patient with adult T cell leukemia/lymphoma.
abstract: A 67-year-old woman with severe pain in the peripheral extremities was admitted to our hospital. Radiography of the peripheral extremities revealed multiple osteolytic lesions. Antibody to human T cell leukemia virus type-I (HTLV-I) was positive, and right radial bone biopsy showed infiltration of adult T cell leukemic (ATL) cells. Irradiation therapy was effective in the osteolytic lesions. In the present case, elevation of IL-6 was detected, suggesting that IL-6 produced by ATL cells is related to their proliferation in the bone, and local osteolysis.
authors.affiliation: Department of Internal Medicine, National Kyushu Medical Center Hospital, Fukuoka.
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Sakai
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005121:Extremities / Q000000981:diagnostic imaging; D005260:Female; D015481:HTLV-I Antibodies / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D010014:Osteolysis / Q000209:etiology* / Q000628:therapy; D011859:Radiography
chemical_list: D015481:HTLV-I Antibodies; D015850:Interleukin-6