[The characteristics of the immune status of patients with lichen ruber planus].
All three main components of the immune system (phagocytosis, humoral and cell-mediated immunity) are changed in patients with lichen ruber planus (LRP). Changes in the functional activity of phagocytes manifest by a decreased phagocytic activity of the peripheral blood monocytes towards Staphylococcus aureus and increased production of active oxygen forms during phagocytosis, which are registered by luminol-dependent chemiluminescence. Changes in the humoral immunity consist in increased serum levels of IgG and IgA, and shifts in the cell-mediated immunity manifest by increased count of cytotoxic CD8+ T lymphocytes and decreased functional activity of T cells recorded by the proliferative response to phytohemagglutinin. The greatest shifts in the immune status are observed in patients with erosive ulcerative LRP, which is characterized by the greatest severity and intensity of inflammation.
Rabinovich
O F
OF
Khanukova
L M
LM
Khamidulina
K F
KF
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000097:blood; D017676:Lichen Planus, Oral / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013211:Staphylococcus aureus
D007136:Immunoglobulins