Ecological approach of macrolide-lincosamides-streptogramin producing actinomyces from Cuban soils.
We report in this study the frequency of Streptomyces strains to produce macrolide-lincosamide-streptogramin (MLS) antibiotics isolated from Cuban soils. The screening assay is based on the induction of MLS-resistance phenotype in a clinical isolated strain of Staphylococcus aureus S-18. Our results suggest that of 800 Streptomyces strains isolated from different soil samples, 6% were positives in the screening test used. The ferralitic red soil from Pinar del Río (north) provided the major percentage (3.6%) of MLS producing strains. The other soil samples tested belonging to Guira de Melena and Bauta in Havana, Matanzas City, Topes De Collantes (Villa Clara), and Soroa Mountains (Pinar del Rio) hill reached very low percentages.
González
I
I
Biotechnology Department, Centre of Pharmaceutical Chemistry, Cubanacán, Havana, Cuba. ily@biocnic.cneuro.edu.cu
Niebla
A
A
Lemus
M
M
González
L
L
Iznaga
I O
IO
Pérez
M E
ME
Vallin
C
C
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D003462:Cuba; D004352:Drug Resistance, Microbial; D008034:Lincomycin / Q000096:biosynthesis / Q000494:pharmacology; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D012988:Soil Microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000302:isolation & purification* / Q000378:metabolism*; D014769:Virginiamycin / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D014769:Virginiamycin; D008034:Lincomycin