Bleomycin-induced scleroderma: report of a case with a chronic course rather than the typical acute/subacute self-limiting form.
We report a case of bleomycin-induced scleroderma in a 35-year-old woman treated with chemotherapy for Hodgkin's disease. Approximately 6 months after the first chemotherapy cycle, the patient developed skin sclerosis in both arms. The lesion showed no signs of spontaneous clinical amelioration and treatment with steroids was unsuccessful. A partial remission of the skin sclerosis was instead obtained by the administration of D-penicillamine. A family history revealed other cases of autoimmune diseases and HLA typing showed the presence of antigens associated with scleroderma. The association between bleomycin therapy and scleroderma is discussed.
Passiu
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G
Cattedra de Reumatologia II, Dipartimentao di Scienze Mediche, Università di Cagliari, Italy.
Cauli
A
A
Atzeni
F
F
Aledda
M
M
Dessole
G
G
Sanna
G
G
Nurchis
P
P
Vacca
A
A
Garau
P
P
Laudadio
M
M
Mathieu
A
A
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D012074:Remission Induction; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000175:diagnosis
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin