Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents.
In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 microM and 300, respectively.
Xia
P
P
Department of Organic Chemistry, School of Pharmacy, Shanghai Medical University, People's Republic of China.
Yang
Z Y
ZY
Xia
Y
Y
Zheng
Y Q
YQ
Cosentino
L M
LM
Lee
K H
KH
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D019380:Anti-HIV Agents; D013256:Steroids