title: Analysis of time-density curves of contrast media for improvement of chest dynamic incremental CT.
abstract: OBJECTIVE
  The goal of this work was to analyze time-density curves (TDCs) of contrast media (CM) in the mediastinal vasculature to optimize chest dynamic incremental CT.
  
  
  METHODS
  Forty-three patients were injected with nonionic CM into the forearm veins with injection rates (ml/s), durations (s), and total amounts (ml) of 2.0, 20, and 40 (protocol 1); 4.0, 20, and 80 (protocol 2); and 2.0, 40, and 80 (protocol 3). TDCs were obtained for the pulmonary trunk (PA) and ascending (AA) and descending (DA) aorta from dynamic scans. Areas under the curves (AUCs) of TDCs for imaginary 30 s scans were evaluated.
  
  
  RESULTS
  AUC peaks were obtained after 10, 17, and 19 s (PA, AA and DA; protocol 1; 9, 16, and 18 s (protocol 2); and 18, 25, and 28 s (protocol 3) delay time.
  
  
  CONCLUSIONS
  Better chest dynamic incremental CT would be expected with scan midpoints a little after the end of injection of CM.
authors.affiliation: Department of Nuclear Medicine and Radiology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Akaizawa
authors.forename: R
authors.initials: R
authors.lastname: Gotou
authors.forename: M B
authors.initials: MB
authors.lastname: Imran
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: A
authors.initials: A
authors.lastname: Qureshy
authors.forename: S
authors.initials: S
authors.lastname: Kinomura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: H
authors.initials: H
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage; D007479:Iopamidol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008175:Lung Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging; D008875:Middle Aged; D013902:Radiography, Thoracic / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media; C057937:iomeprol; D007472:Iohexol; D007479:Iopamidol