[Biology of the papillomavirus infections: V. Vaccine developments].
Several genotypes of human papillomaviruses (HPV) are recognised as aetiologic factors for cervical cancer, and viral DNA account for more 99% of cases. Thus, prevention of HPV infection by, for example, types 16 and 18, should reduce the world-wide incidence of cervical cancer. Many strategies are being developed for the control of HPV-associated lesions of the uterine cervix: prophylactic vaccines which elicit neutralizing antibodies to prevent HPV infection, and therapeutic vaccines which induce a T-cytotoxic response to early viral oncoproteins. Experimental trials are being conducted to test mucosal immunization with an ideal antigen delivery system. Vaccination strategies elicit a protective antibody response in animal species, but in humans, strategies which are likely to be effective in the control of HPV-associated preneoplastic and neoplastic lesions of the uterine cervix are still under investigation.
Seilles
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E
Laboratoire de virologie-biologie cellulaire-immunologie, UPRES EA 2085, Institut d'étude et de transfert de gènes, Faculté de médecine et de pharmacie-de Besançon, 2, place Saint-Jacques, 25030 Besançon Cedex.
Riethmuller
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D
Mougin
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C
D000818:Animals; D000914:Antibodies, Viral / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D015513:Oncogene Proteins / Q000276:immunology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D030361:Papillomavirus Infections / Q000517:prevention & control*; D053918:Papillomavirus Vaccines; D011230:Precancerous Conditions / Q000517:prevention & control / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014412:Tumor Virus Infections / Q000517:prevention & control*; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control / Q000821:virology; D014611:Vaccination; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines
D000914:Antibodies, Viral; D004279:DNA, Viral; D015513:Oncogene Proteins; D053918:Papillomavirus Vaccines; D014764:Viral Proteins; D014765:Viral Vaccines