An unusual case of intrapulmonary granulocytic sarcoma presenting as interstitial pneumonitis following allogeneic bone marrow transplantation for acute myeloid leukaemia and responding to donor lymphocyte infusion.
We report a 45-year-old female with AML who underwent a T cell-depleted sibling allograft and relapsed a year later with extramedullary disease involving the lung parenchyma and presenting with the clinical and radiological features of interstitial pneumonitis. The patient was treated with donor lymphocyte infusion (DLI) resulting in complete resolution of the radiological signs. The unusual presentation and the management options are discussed.
Kottaridis
P D
PD
Department of Haematology, University College London Hospitals, UK.
Ketley
N
N
Peggs
K
K
Chakraverty
R
R
Ralleigh
G
G
Shaw
P
P
Pezzella
F
F
Goldstone
A H
AH
Devereux
S
S
Mackinnon
S
S
D016026:Bone Marrow Transplantation / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D017710:Lymphocyte Transfusion / Q000009:adverse effects; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local