Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung.
The pulmonary toxicity of two potential environmental pollutants was studied in rats 1, 7 and 30 days after a single intratracheal instillation of lead nitrate and Dithane M-45 (mancoceb), either individually or in various combinations. The cell count, protein, phospholipids and lactate dehydrogenase level were determined in the bronchoalveolar lavage fluid, as were the protein, phospholipids and acid phosphatase contents in the lung tissue. Lead nitrate and Dithane M-45 induced acute inflammation reactions with different features. The effects of mixtures of lead nitrate and Dithane M-45 were found to be different from those of the individual components.
Adamis
Z
Z
OKK National Institute of Chemical Safety, Budapest, Hungary.
Tátrai
E
E
Honma
K
K
Ungváry
G
G
D000135:Acid Phosphatase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005355:Fibrosis; D005659:Fungicides, Industrial / Q000633:toxicity*; D015386:Hazardous Substances / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D008344:Maneb / Q000031:analogs & derivatives* / Q000633:toxicity; D009566:Nitrates / Q000633:toxicity*; D010743:Phospholipids / Q000378:metabolism; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests; D015038:Zineb / Q000031:analogs & derivatives* / Q000633:toxicity
D005659:Fungicides, Industrial; D015386:Hazardous Substances; D009566:Nitrates; D010743:Phospholipids; D011506:Proteins; D008344:Maneb; D007854:Lead; C011453:dithane M-45; C017461:lead nitrate; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase; D015038:Zineb