title: [Transfusion-related lung injury edema].
abstract: BACKGROUND
  Transfusion-related acute lung injury (TRALI) is a relatively rare but potentially severe complication of blood transfusion that should be diagnosed.
  
  
  METHODS
  The origin of this complication is most often an immunological leucocyte conflict due to transfused plasma HLA antibodies. Prevention (anti-HLA antibody screening in blood donors and elimination of blood products from immunized donors) is discussed.
  
  
  CONCLUSIONS
  Transfusion-related acute lung injury should be suspected in transfusion-related respiratory distress, after elimination of potential pulmonary edema due to overloading. An immunologic cause should always be searched for. Leukodepletion of blood products and harmonization in blood donor selection should prevent this rare complication.
authors.affiliation: ETS AP-HP, Hôtel-Dieu, Paris, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Fruchart
authors.forename: J
authors.initials: J
authors.lastname: Klaren
authors.forename: R
authors.initials: R
authors.lastname: Belhocine
authors.forename: H
authors.initials: H
authors.lastname: Ben Hadj Amor
mesh_terms: D000208:Acute Disease; D000328:Adult; D001782:Blood Donors; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011654:Pulmonary Edema / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D012131:Respiratory Insufficiency / Q000209:etiology; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies