Pregnancies resulting from in vitro matured oocytes retrieved from patients with polycystic ovary syndrome after priming with human chorionic gonadotropin.
OBJECTIVE
To describe pregnancies that resulted from in vitro matured oocytes derived from two unstimulated, anovulatory patients with polycystic ovary syndrome after priming with hCG before oocyte retrieval.


METHODS
Case series.


METHODS
McGill Reproductive Center, Royal Victoria Hospital, McGill University.


METHODS
Two women with polycystic ovary syndrome.


METHODS
Progesterone induction of a withdrawal bleeding episode. The administration of subcutaneous hCG 36 hours before oocyte retrieval in a natural menstrual cycle. In vitro maturation of immature oocytes, fertilization, and ET. Luteal support with oral estrogen and progesterone.


METHODS
Pregnancy outcome.


RESULTS
Two clinical pregnancies were confirmed after oocyte maturation in vitro, fertilization with intracytoplasmic sperm injection, and ET.


CONCLUSIONS
The administration of hCG 36 hours before harvesting of immature oocytes may improve the maturational and developmental competence of the oocytes and the pregnancy rates of unstimulated patients with polycystic ovary syndrome.
Chian
R C
RC
McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. rchian@rvhob2.lan.mcgill.ca
Buckett
W M
WM
Too
L L
LL
Tan
S L
SL
D000328:Adult; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000473:pathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting
D006063:Chorionic Gonadotropin