Stability and compatibility of an aerosol mixture including N-acetylcysteine, netilmicin and betamethasone.
The physicochemical stability and the compatibility between N-acetylcysteine (1 g/5 ml), betamethasone (4 mg/1 ml) and netilmicin (100 mg/1 ml) were studied at room temperature (25+/-2 degrees C) over 1 h. During this study, drug concentrations were measured using three separate HPLC methods with UV detection at t=0, 5, 10, 20, 30, and 60 min. The pH of the mixture was determined. Degradation products of the drugs were assayed using HPLC. This study demonstrates the stability and compatibility of the mixture over 1 h at room temperature. The pinkish non-remnant coloration observed when pouring N-acetylcysteine into a recipient has no effect on the stability of the drug.
Rieutord
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A
Service de Pharmacie et Laboratoire de Toxico-Pharmacologie, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019, Paris, France.
Arnaud
P
P
Dauphin
J F
JF
Brion
F
F
D000111:Acetylcysteine / Q000032:analysis / Q000737:chemistry*; D000336:Aerosols / Q000032:analysis / Q000737:chemistry; D001623:Betamethasone / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D004344:Drug Incompatibility; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D009428:Netilmicin / Q000032:analysis / Q000737:chemistry*; D013997:Time Factors
D000336:Aerosols; D009428:Netilmicin; D001623:Betamethasone; D000111:Acetylcysteine