Successful treatment of post-influenza pseudomembranous necrotising bronchial aspergillosis with liposomal amphotericin, inhaled amphotericin B, gamma interferon and GM-CSF.
A case of aspergillus tracheobronchitis following influenza A infection in an immunocompetent 35 year old woman is described that required prolonged mechanical ventilation for airways obstruction. Treatment included liposomal amphotericin, inhaled amphotericin, gamma interferon and GM-CSF. Liposomal amphotericin therapy was associated with reversible hepatosplenomegaly. Inhaled corticosteroids with continued antifungal therapy were used for the management of severe recurrent airway obstruction. After a prolonged course of treatment she survived with fixed airways obstruction unresponsive to corticosteroids.
Boots
R J
RJ
Department of Anaesthesiology and Intensive Care, Herston, Queensland, Australia 4029.
Paterson
D L
DL
Allworth
A M
AM
Faoagali
J L
JL
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy*; D001234:Aspergillus niger; D001991:Bronchitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000150:complications; D007371:Interferon-gamma / Q000627:therapeutic use*; D014136:Tracheitis / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D000666:Amphotericin B; D007371:Interferon-gamma