Natural interferon therapy: optic nerve ischemic damage?
The purpose of this study was the evaluation of retinal abnormalities during a treatment with natural interferon (IFN-alpha for chronic hepatitis C. Retinal hemorrhages and optic disk edema were found in a 40-year-old woman during IFN-alpha therapy. The disk edema and retinopathy resolved after the INF was discontinued. Although retinal abnormalities correlated with IFN therapy have been described recently by some authors, the pathogenesis is still unclear. Anterior ischemic optic neuropathy occurring in a patient treated with IFN is a probable complication of the therapy.
Norcia
F
F
Ophthalmic Clinic, IRCCS-Policlinico San Matteo, University of Pavia, Italy.
Di Maria
A
A
Prandini
F
F
Redaelli
C
C
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005451:Fluorescein Angiography; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D007511:Ischemia / Q000139:chemically induced*; D009900:Optic Nerve / Q000098:blood supply*; D010211:Papilledema / Q000139:chemically induced / Q000175:diagnosis; D012166:Retinal Hemorrhage / Q000139:chemically induced / Q000175:diagnosis
D000998:Antiviral Agents; D016898:Interferon-alpha