Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes.
OBJECTIVE
To evaluate optic disc and retinal nerve fiber layer (RNFL) appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT).


METHODS
Prospective, cross-sectional study.


METHODS
Seventy-eight eyes of 78 consecutive normal (n = 17), ocular-hypertensive (n = 23), and glaucomatous subjects (n = 38) were enrolled.


METHODS
Each patient underwent complete ophthalmic examination, achromatic automated perimetry, confocal scanning laser ophthalmoscopy (Heidelberg Retinal Tomography [HRT]), and OCT. Topographic HRT parameters (disc area, cup-disc ratio, rim area, rim volume, cup shape measure, mean RNFL thickness, and cross-sectional area) and mean OCT-generated RNFL thickness were evaluated in each group.


METHODS
OCT and HRT assessment of optic disc and RNFL anatomy.


RESULTS
OCT RNFL thickness showed no difference between normal and ocular-hypertensive eyes (P = 0.15) but was significantly less in glaucomatous eyes (P < 0.001). HRT measurements of rim area, cup-disc ratio, cup shape measure, RNFL thickness, and RNFL cross-sectional area were significantly less in glaucomatous eyes (all P < 0.005) and were correlated with mean OCT RNFL thickness (all P < 0.02). RNFL thickness using OCT or HRT was highly correlated with visual field mean defect during achromatic perimetry (P < 0.0001).


CONCLUSIONS
Both HRT and OCT can differentiate glaucomatous from nonglaucomatous eyes. RNFL thickness measurements using OCT correspond to disc topographic parameters using HRT.
Mistlberger
A
A
Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA.
Liebmann
J M
JM
Greenfield
D S
DS
Pons
M E
ME
Hoh
S T
ST
Ishikawa
H
H
Ritch
R
R
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis*; D009887:Ophthalmoscopy; D009898:Optic Disk / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D011446:Prospective Studies; D014054:Tomography / Q000379:methods*; D058609:Visual Field Tests; D014794:Visual Fields