[Treatment of idiopathic thrombocytopenic purpura in adults: efficacy of domestic intravenous immunoglobulin in immune thrombocytopenia].
OBJECTIVE
The study of effectiveness of intravenous immunoglobulin (IVIG) in therapy of idiopathic thrombocytopenic purpura (ITP) in adults.


METHODS
High doses of IVIG (0.2-0.4 g/kg b.w. for 4-6 days) were given to 6 female patients aged 20 to 59 years (median--39 years) with immune thrombocytopenia. 4 patients had primary ITP resistant to glucocorticosteroids (GCS) and 1 female had chronic ITP treated by splenectomy without effect. 1 patient with rheumatoid arthritis developed severe thrombocytopenia combined with agranulocytosis when treated with nonsteroid antiinflammatory drugs.


RESULTS
The response was observed in 5 of 6 patients (in 4 patients resistant to GCS and 1 RA patient). In 3 of them the effect was rated as excellent (platelets level > 150,000 per cubic millimeter), in 2 patients it was good (platelets count from 50,000 to 150,000 per cubic millimeter). Splenectomy was performed in 4 cases with ITP on day 8-14 after IVIG therapy. The 2- and 6-month follow-up evidenced for good results of the surgical treatment. The RA patient showed a stable rise of the blood count. Serious side effects of IVIG therapy were not registered.


CONCLUSIONS
IVIG of Russian produce is effective in the treatment of drug-induced thrombocytopenia and ITP resistant to GCS.
Pugina
S A
SA
Evdokimova
N M
NM
Rastorguev
G G
GG
Samoĭlova
O S
OS
Sorokina
I V
IV
Sidnev
G V
GV
Vasil'ev
D M
DM
Anastasiev
V V
VV
Milovidova
O V
OV
Molodovskaia
E V
EV
Borovkov
N N
NN
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D012426:Russia; D013156:Splenectomy; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous