[GABA-A receptor subunits and their reactions to neuropharmacological substances].
The structural-functional foundations of the heterogeneity of GABA(A)-receptors are discussed. The heterogeneity of the receptors was revealed by clone-formation methods. The existence of 5 classes of subunits (alpha, beta, gamma, delta, rho) was proved, each of them possessing isoforms (alpha 1-6, beta 1-4, gamma 1-4, delta, rho 1-2). Studies with expression of receptors showed the efficacy of neuroactive drugs of various groups (agonists, antagonists, reversible agonists of benzodiazepine receptors, barbiturates) to be dependent on the subunit composition of the complexes. Because of this, study of the properties of various recombinant receptors is very important for the advancement of neurobiology, neuropathology, neurochemistry, toxicology, and pharmacology.
Golovko
A I
AI
Military Medical Academy, St. Petersburg, Russia.
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology; D008024:Ligands; D011963:Receptors, GABA-A / Q000145:classification / Q000187:drug effects* / Q000502:physiology
D001463:Barbiturates; D008024:Ligands; D011963:Receptors, GABA-A; D001569:Benzodiazepines