title: Retrograde cerebral perfusion as an adjunct to prolonged hypothermic circulatory arrest.
abstract: OBJECTIVE
  This study was designed to evaluate the use of retrograde cerebral perfusion (RCP) combined with deep hypothermic circulatory arrest (DHCA) in the treatment of complex congenital and adult cardiac disease.
  
  
  METHODS
  Retrospective chart review of 52 cardiac surgery patients (34 male and 18 female; age range, 3 weeks to 89 years old; mean age, 60 years old) who received RCP in conjunction with DHCA from July 1991 through August 1998.
  
  
  RESULTS
  Surgical procedures consisted of the following: (1) repair of ascending aortic aneurysms (n = 16); (2) repair of type A aortic dissection (n = 16); (3) repair of arch aneurysms (n = 10); (4) renal cell carcinoma with tumor extension to the inferior vena cava (IVC) and right atrium (n = 5); (6) coronary artery bypass grafting and concomitant aortic valve replacement with calcified aorta (n = 2); (7) Norwood procedure and take down of a Pott's shunt (n = 2); and (8) massive air embolism treatment (n = 1). Mean RCP time was 39 min (range, 3 to 88 min). Thirteen patients had RCP times > 60 min. Mean core temperature (rectal or bladder) was 19 degrees C (range, 15 degrees to 28 degrees C). There were six early deaths, four of which were related to persistent low-output cardiac failure, and two resulted from perioperative stroke. All remaining patients recovered fully without neurologic deficits.
  
  
  CONCLUSIONS
  RCP is a reliable and technically appealing tool that does the following: (1) it improves DHCA safety and is applicable in a variety of clinical settings with relative ease; (2) it potentially provides oxygen and nutritional support to the brain during DHCA; (3) it helps remove air and other debris from the cerebral vessels; and (4) it is useful in dealing with congenital heart disease and tumor extension into the IVC.
authors.affiliation: Department of Surgery, University of California at Los Angeles Medical Center, Los Angeles, CA 90095-1741, USA. fesmaili@surgery.medsch.ucla.edu
authors.forename: F
authors.initials: F
authors.lastname: Esmailian
authors.forename: H
authors.initials: H
authors.lastname: Dox
authors.forename: A
authors.initials: A
authors.lastname: Sadeghi
authors.forename: K
authors.initials: K
authors.lastname: Eghbali
authors.forename: H
authors.initials: H
authors.lastname: Laks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000098:blood supply*; D006348:Cardiac Surgical Procedures; D002423:Cause of Death; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006330:Heart Defects, Congenital / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006331:Heart Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007036:Hypothermia, Induced; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D020521:Stroke / Q000401:mortality / Q000503:physiopathology