title: Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice.
abstract: Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage.
authors.affiliation: Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Dieterich
authors.forename: H
authors.initials: H
authors.lastname: Bouzourène
authors.forename: A L
authors.initials: AL
authors.lastname: Blum
authors.forename: I E
authors.initials: IE
authors.lastname: Corthésy-Theulaz
mesh_terms: D000818:Animals; D001284:Atrophy; D001428:Bacterial Vaccines / Q000276:immunology*; D002772:Cholera Toxin / Q000276:immunology; D005753:Gastric Mucosa / Q000473:pathology*; D016998:Helicobacter / Q000276:immunology*; D016481:Helicobacter Infections / Q000517:prevention & control*; D018928:Immunity, Mucosal; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000276:immunology; D014510:Urease / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D002772:Cholera Toxin; D014510:Urease