Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF.
The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.
Steinmann
T
T
Entwicklungsgenetik, Zentrum für Molekularbiologie der Pflanzen, Universität Tübingen, Auf der Morgenstelle 1, D-72076 Tübingen, Germany.
Geldner
N
N
Grebe
M
M
Mangold
S
S
Jackson
C L
CL
Paris
S
S
Gälweiler
L
L
Palme
K
K
Jürgens
G
G
D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D017360:Arabidopsis / Q000166:cytology / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins; D001692:Biological Transport; D020126:Brefeldin A / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D003600:Cytosol / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D018517:Plant Roots / Q000254:growth & development / Q000378:metabolism; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000378:metabolism; D012639:Seeds / Q000166:cytology / Q000378:metabolism; D012995:Solubility; D013347:Subcellular Fractions / Q000378:metabolism
D029681:Arabidopsis Proteins; D020662:Guanine Nucleotide Exchange Factors; D007210:Indoleacetic Acids; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C116363:PIN1 protein, Arabidopsis; D011994:Recombinant Proteins; D020126:Brefeldin A; D020727:ADP-Ribosylation Factors