title: Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula.
abstract: A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine cyanobacterium Lyngbya majuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolute configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGME amide derivatives by (1)H NMR.
authors.affiliation: College of Pharmacy, Oregon State University, Corvallis, Oregon, 97331-3507, USA.
authors.forename: I P
authors.initials: IP
authors.lastname: Singh
authors.forename: K E
authors.initials: KE
authors.lastname: Milligan
authors.forename: W H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D000458:Cyanobacteria / Q000302:isolation & purification*; D033364:Decapoda / Q000187:drug effects; D006054:Goldfish; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008974:Mollusca / Q000187:drug effects; D013057:Spectrum Analysis
chemical_list: D000935:Antifungal Agents; D007783:Lactones; C400156:tanikolide