Large cell, epithelioid, telangiectatic osteoblastoma: a unique pseudosarcomatous variant of osteoblastoma.
A previously undescribed large-cell, epithelioid, and aneurysmal variant of osteoblastoma with minimal osteoid-production--simulating telangiectatic osteosarcoma, epithelioid angiosarcoma, and metastatic carcinoma is reported. The tumor occurred in the mandible of a 14-year-old girl. The light microscopic, immunohistochemical, ultrastructural, cell proliferation, and DNA-ploidy studies, as well as the 7-year disease-free follow-up period all indicate a benign osteoblastic tumor. Cytogenetically, the tumor had a pseudodiploid karyotype, distinguished by a complex t(1;5;17;22) and a terminal 1q deletion. Recognition of this unique, pseudomalignant variant of osteoblastoma is important to avoid an erroneous diagnosis of malignancy.
Angervall
L
L
Department of Pathology, Sahlgrenska University Hospital, Göteborg, Sweden.
Persson
S
S
Stenman
G
G
Kindblom
L G
LG
D000293:Adolescent; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007621:Karyotyping; D008339:Mandibular Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D018215:Osteoblastoma / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D011859:Radiography; D013684:Telangiectasis / Q000473:pathology*
D004247:DNA