[Bone marrow transplantation in the treatment of autoimmune diseases. ISAMAIR Group].
EXPERIMENTAL BASIS AND CLINICAL OBSERVATIONS: Remission of an autoimmune disease has been observed in certain patients after bone marrow allograft from a healthy donor. Autoimmune disease in the donor can also be transmitted to an unaffected recipient. These phenomena would be hematopoietic-dependent. BONE MARROW ALLOGRAFTS: Indications for the treatment of refractory autoimmune diseases are exceptional due to the related mortality even in patients without malignant hematologic disease. A NEW THERAPEUTIC CONCEPT: Therapeutic intensification, followed with autologous peripheral stem cell grafts, a procedure with a mortality below 3% in 1997, constitutes a therapeutic alternative in these difficult indication concerning severe refractory autoimmune diseases including: sclerodermia, vasculitis, lupus, inflammatory myositis, autoimmune cyopenia.
Farge
D
D
Service de Médecine interne, Hôpital Saint Louis, Paris.
Breban
M
M
Guillevin
L
L
Piette
J C
JC
Cabane
J
J
Cherin
P
P
Cosserat
J
J
Sicard
D
D
Ribaud
P
P
Marolleau
J P
JP
Bouscary
D
D
Mariette
X
X
Gisselbrecht
C
C
Gluckman
E
E
D001327:Autoimmune Diseases / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous