Phenotypic analysis of peripheral lymphocyte subpopulations in hydatid patients.
Peripheral T-lymphocytes were analyzed in three groups of people: (1) individuals with current liver hydatid disease (hydatid patients, n = 20), (2) persons who had undergone surgical cyst removal at least 2 years previously (recovered patients, n = 9), and (3) a control group of healthy volunteers (uninfected controls, n = 13). Group 1 was subdivided according to cyst status, relapse of disease, and the presence or absence of symptoms. Percentages of lymphocytes expressing CD3, CD4, CD8, CD56, CD25, CD45RA, CD45RO, and HLA-DR were determined. Symptomatic patients had proportionally fewer CD3+ CD8 + lymphocytes than the control group (P=0.038). Hydatid patients with active cysts had proportionally more natural killer cells (CD56 + CD8-) than the control group (P = 0.028).
Hernández
A
A
Unidad Central de Investigación, Facultad de Medicina, Universitat de Valencia, Hospital Clínico Universitario, Spain.
O'Connor
J E
JE
Mir
A
A
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D004444:Echinococcosis, Hepatic / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007963:Leukocytes, Mononuclear / Q000166:cytology; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD