title: Mucosal tissue oxygenation of the porcine jejunum during normothermic cardiopulmonary bypass.
abstract: Cardiopulmonary bypass (CPB) has been associated with intestinal tissue hypoxia, but direct measurements of mucosal oxygenation have not been performed. In anaesthetized pigs, jejunal mucosal oxygen tension and microvascular haemoglobin oxygen saturation were measured by a Clark-type electrode and tissue reflectance spectrophotometry. In pigs, normothermic CPB with systemic oxygen transport equivalent to baseline values was performed. In control animals, mucosal oxygen tension and mucosal haemoglobin oxygen saturation were mean 5.01 (SD 1.08) kPa and 38.0 (2.3)%, respectively. CPB was associated with a decrease in mucosal oxygen tension to 2.26 (1.21) kPa, decrease in mucosal microvascular haemoglobin oxygen saturation to 26.0 (3.9)% and appearance of oscillations in mucosal microvascular haemoglobin oxygen saturation. With CPB, arterial lactate concentrations increased from 1.77 (1.37) to 3.52 (1.58) mmol litre-1, but transvisceral lactate and splanchnic venous-arterial carbon dioxide tension gradients remained unchanged. Our results support the concept that CPB is associated with diminished oxygenation of intestinal mucosa that is probably caused by regional redistribution.
authors.affiliation: Department of Anaesthesia and Intensive Care, University Hospital Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Haisjackl
authors.forename: R
authors.initials: R
authors.lastname: Germann
authors.forename: W
authors.initials: W
authors.lastname: Hasibeder
authors.forename: B
authors.initials: B
authors.lastname: Schwarz
authors.forename: N
authors.initials: N
authors.lastname: Salak
authors.forename: W
authors.initials: W
authors.lastname: Pajk
authors.forename: J
authors.initials: J
authors.lastname: Bonatti
authors.forename: W
authors.initials: W
authors.lastname: Nussbaumer
authors.forename: G
authors.initials: G
authors.lastname: Klima
authors.forename: W
authors.initials: W
authors.lastname: Kox
authors.forename: N
authors.initials: N
authors.lastname: Mutz
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D006439:Hemodynamics; D007413:Intestinal Mucosa / Q000098:blood supply / Q000378:metabolism*; D007583:Jejunum / Q000098:blood supply / Q000378:metabolism*; D008833:Microcirculation; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D010313:Partial Pressure; D011897:Random Allocation; D013552:Swine; D013696:Temperature
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen