title: Failure of preventive effects of 2-deoxy-D-glucose on ischemia-induced gerbil hippocampal neuronal damage by induced hyperthermia.
abstract: Post-ischemic administration of 2-deoxy-D-glucose (2-DG), a glucose antimetabolite, markedly reduces the occurrence of ischemia-induced delayed neuronal death (DND) in the gerbil hippocampus. This means that the reduction of energy dependent metabolism after ischemia prevents ischemia-induced damages of hippocampal neurons. In the present study, we demonstrated hyperthermia during ischemia fails to preserve neurons in hippocampal CA1 of 2-DG treated gerbil following transient forebrain ischemia.
authors.affiliation: Department of Pathology, Gifu University School of Medicine, Gifu, Japan. ahara@cc.gifu-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Iwai
authors.forename: H
authors.initials: H
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Nakashima
authors.forename: Y
authors.initials: Y
authors.lastname: Bunai
authors.forename: T
authors.initials: T
authors.lastname: Uematsu
authors.forename: N
authors.initials: N
authors.lastname: Yoshimi
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D006979:Hyperthermia, Induced; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000473:pathology*
chemical_list: D000963:Antimetabolites; D003847:Deoxyglucose