[The embryo-protective action of antifein derivatives in chloridin-induced teratogenesis].
We studied the effect of propyl- and ethylnorantifein on chloridine-induced abnormalities of extremities in rat embryos. Chloridine (50 and 25 mg/kg, given through the gastric tube) was administered to rats on day 14 of pregnancy, and its embryotoxic effect was estimated from the state of fetuses and implantation sites on day 20 of prenatal development. Propylnorantifein had fetoprotective properties both after intraperitoneal (10 mg/kg) and after intraamniotic (6 and 0.06 micrograms) administration. Ethylnorantifein under similar conditions does not change the action of chloridine, and it prevents the appearance of developmental abnormalities only at the concentration of 0.06 microgram/embryo. These data are discussed in connection with different effects of antifein derivatives on chromatin proteinkinase, which phosphorylates HMG nonhistone proteins.
Bichevaia
N K
NK
Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Chebotar'
N A
NA
Aleksandrova
I Ia
IIa
Stepanov
I I
II
Klement'ev
B I
BI
Sapronov
N S
NS
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D020964:Embryo Loss / Q000139:chemically induced / Q000517:prevention & control; D004622:Embryo, Mammalian / Q000187:drug effects*; D005042:Etimizol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D011247:Pregnancy; D011739:Pyrimethamine / Q000633:toxicity*; D051381:Rats; D013723:Teratogens / Q000633:toxicity*
D007093:Imidazoles; D013723:Teratogens; C026619:propylnorantifein; C014337:Antiphein; D005042:Etimizol; D011739:Pyrimethamine