title: Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report.
abstract: The author presents the case of a patient with gelastic seizures associated with a hypothalamic hamartoma, in whom partial resection of the hamartoma followed by temporal lobectomy and orbitofrontal corticectomy failed to reduce the seizures. Subsequent stereotactic radiofrequency ablation of the hamartoma resulted in progressive improvement in the seizure disorder during a 28-month follow-up period. There is support in the literature for the concept that gelastic seizures originate directly from the hamartoma; however, direct surgical approaches to these lesions pose significant risks. It is proposed that the technique of radiofrequency ablation provides a minimally invasive, low-risk approach for the treatment of hypothalamic hamartomas.
authors.affiliation: Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario, Canada. andrew.parrent@lhsc.on.ca
authors.forename: A G
authors.initials: AG
authors.lastname: Parrent
mesh_terms: D017115:Catheter Ablation; D002648:Child; D004828:Epilepsies, Partial / Q000209:etiology* / Q000601:surgery*; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D007031:Hypothalamus / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008326:Mammillary Bodies / Q000601:surgery; D016634:Radiosurgery; D013702:Temporal Lobe / Q000601:surgery