Antiulcer effect of the N- and O-beta-D-glucopyranosides of 5-aminosalicylic acid.
Starting from methyl 5-nitrosalicylate (20) the N- and O-beta-glucopyranosyl derivatives (24, 28) of 5-aminosalicylic acid were prepared. The LD50 values of these compounds were determined on mice, and the inhibitory effect of 24 (0.83 mmol/kg) and 28 (1.2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated.
Sztaricskai
F
F
Research Group of Antibiotics, Hungarian Academy of Sciences, Lajos Kossuth University, Debrecen, Hungary.
Takács
I E
IE
Pusztai
F
F
Szabó
G
G
Csípõ
I
I
D000636:Aminosalicylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007213:Indomethacin; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D005960:Glucosides; D007213:Indomethacin