Evidence for oxidant stress in chronic pancreatitis.
BACKGROUND
Oxidant stress leading to lipid peroxidation is reported to be the common link in the pathogenesis of chronic pancreatitis irrespective of etiology.


OBJECTIVE
To look for evidence of lipid peroxidation in duodenal juice in patients with chronic pancreatitis.


METHODS
19 patients with chronic pancreatitis (14 tropical, 5 alcoholic) and 19 age- and sex-matched subjects with abdominal pain without any cause were studied. Contents were aspirated from the second part of the duodenum during gastroduodenoscopy. Malonyl dialdehyde (MDA) levels were measured in duodenal juice by the thiobarbituric acid method.


RESULTS
MDA levels were higher in patients than in the control group (mean [SD] 42.6 [17.0] vs 29.2 [11.7] nmol/mL; p < 0.05). On linear and multiple regression analysis, none of the disease factors correlated with duodenal juice MDA levels.


CONCLUSIONS
Lipid peroxidation products are increased in patients with chronic tropical and alcoholic pancreatitis.
Ganesh Pai
C
C
Gastroenterology Unit, Kasturba Medical College, Manipal.
Sreejayan
Rao
M N
MN
D000328:Adult; D002908:Chronic Disease; D004386:Duodenum / Q000378:metabolism; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000737:chemistry; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010195:Pancreatitis / Q000378:metabolism*
D008315:Malondialdehyde