title: Training ribozymes to switch.
abstract: Ribozymes that are sensitive to cyclic nucleotides have been selected in vitro. Remarkably, the cGMP-dependent ribozymes are specifically activated by a factor of 5,000 - the largest allosteric ribozyme activation by a small molecule seen to date.
authors.affiliation: Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Marshall
authors.forename: A D
authors.initials: AD
authors.lastname: Ellington
mesh_terms: D000494:Allosteric Regulation / Q000187:drug effects; D002384:Catalysis / Q000187:drug effects; D006152:Cyclic GMP / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005818:Genetic Engineering / Q000379:methods*; D009690:Nucleic Acid Conformation / Q000187:drug effects*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016337:RNA, Catalytic / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
chemical_list: D016337:RNA, Catalytic; D006152:Cyclic GMP