A new statistical method for transfer coefficient calculations in the framework of the general multiple-compartment model of transport for radionuclides in biological systems.
A new and simple statistical procedure (STATFLUX) for the calculation of transfer coefficients of radionuclide transport to animals and plants is proposed. The method is based on the general multiple-compartment model, which uses a system of linear equations involving geometrical volume considerations. By using experimentally available curves of radionuclide concentrations versus time, for each animal compartment (organs), flow parameters were estimated by employing a least-squares procedure, whose consistency is tested. Some numerical results are presented in order to compare the STATFLUX transfer coefficients with those from other works and experimental data.
Garcia
F
F
Instituto de Física, Universidade de São Paulo, Brazil.
Arruda-Neto
J D
JD
Manso
M V
MV
Helene
O M
OM
Vanin
V R
VR
Rodriguez
O
O
Mesa
J
J
Likhachev
V P
VP
Filho
J W
JW
Deppman
A
A
Perez
G
G
Guzman
F
F
de Camargo
S P
SP
D000818:Animals; D001692:Biological Transport; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D010944:Plants / Q000378:metabolism; D011868:Radioisotopes / Q000493:pharmacokinetics*; D012984:Software; D014018:Tissue Distribution
D011868:Radioisotopes