title: State-of-the-art in liquid chromatography-mass spectrometry.
abstract: Impressive progress has been made in the technology and application of combined liquid chromatography-mass spectrometry (LC-MS) in the past decennium. From a technique, that could only be used by a specialist, it has developed into a routinely applicable technique. LC-MS has become the method-of-choice of analytical support in many stages of drug development within pharmaceutical industries and has found its way into environmental, biochemical and other laboratories. This paper provides a perspective on the current technology, principles and applications of LC-MS.
authors.affiliation: Hyphen MassSpec Consultancy, Leiden, The Netherlands.
authors.forename: W M
authors.initials: WM
authors.lastname: Niessen
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*