title: Repetitive hydatidiform mole with different male partners.
abstract: OBJECTIVE
  The aim of this study was to determine the role of parental factors that may relate to the pathogenesis of molar pregnancy.
  
  
  METHODS
  A retrospective review of six patients who had a molar pregnancy with at least two different partners at New England Trophoblastic Disease Center between 1965 and March 1999 was performed.
  
  
  RESULTS
  A total of 34 pregnancies with 20 different partners were observed in 6 patients. These pregnancies resulted in 15 (44.1%) hydatidiform moles, 8 (23.5%) term live births, 7 (20.6%) therapeutic abortions, 3 (8.8%) spontaneous abortions, and 1 preterm delivery. While 5 patients had a molar pregnancy with 2 different partners, 1 patient had a molar pregnancy with 3 different partners. Two patients developed persistent postmolar gestational trophoblastic tumor in 3 (20.0%) of the 15 episodes of molar pregnancy. Three of the male partners reported a total of 7 healthy children from prior relationships.
  
  
  CONCLUSIONS
  The experience in these six patients suggests that a primary oocyte problem may contribute to the development of molar pregnancy.
authors.affiliation: Gillette Center for Women's Cancers, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Tuncer
authors.forename: M R
authors.initials: MR
authors.lastname: Bernstein
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: D P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: R S
authors.initials: RS
authors.lastname: Berkowitz
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012747:Sexual Partners; D014594:Uterine Neoplasms / Q000453:epidemiology*