title: Coordinated polar localization of auxin efflux carrier PIN1 by GNOM ARF GEF.
abstract: The plant hormone auxin is transported in a polar manner along the shoot-root axis, which requires efflux carriers such as PIN1. Asymmetric localization of PIN1 develops from a random distribution in Arabidopsis early embryogenesis. Coordinated polar localization of PIN1 is defective in gnom embryos. GNOM is a membrane-associated guanine-nucleotide exchange factor on ADP-ribosylation factor G protein (ARF GEF). Thus, GNOM-dependent vesicle trafficking may establish cell polarity, resulting in polar auxin transport.
authors.affiliation: Entwicklungsgenetik, Zentrum für Molekularbiologie der Pflanzen, Universität Tübingen, Auf der Morgenstelle 1, D-72076 Tübingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Steinmann
authors.forename: N
authors.initials: N
authors.lastname: Geldner
authors.forename: M
authors.initials: M
authors.lastname: Grebe
authors.forename: S
authors.initials: S
authors.lastname: Mangold
authors.forename: C L
authors.initials: CL
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Paris
authors.forename: L
authors.initials: L
authors.lastname: Gälweiler
authors.forename: K
authors.initials: K
authors.lastname: Palme
authors.forename: G
authors.initials: G
authors.lastname: Jürgens
mesh_terms: D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D017360:Arabidopsis / Q000166:cytology / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins; D001692:Biological Transport; D020126:Brefeldin A / Q000494:pharmacology; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D003600:Cytosol / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D018517:Plant Roots / Q000254:growth & development / Q000378:metabolism; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000378:metabolism; D012639:Seeds / Q000166:cytology / Q000378:metabolism; D012995:Solubility; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D020662:Guanine Nucleotide Exchange Factors; D007210:Indoleacetic Acids; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C116363:PIN1 protein, Arabidopsis; D011994:Recombinant Proteins; D020126:Brefeldin A; D020727:ADP-Ribosylation Factors