title: Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives.
abstract: In a search for antiprotozoan compounds, 34 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan activity. In vivo assays of compounds which showed remarkable in vitro activity against T. vaginalis were carried out.
authors.affiliation: Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Ochoa
authors.forename: E
authors.initials: E
authors.lastname: Pérez
authors.forename: R
authors.initials: R
authors.lastname: Pérez
authors.forename: M
authors.initials: M
authors.lastname: Suárez
authors.forename: E
authors.initials: E
authors.lastname: Ochoa
authors.forename: H
authors.initials: H
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Gómez Barrio
authors.forename: S
authors.initials: S
authors.lastname: Muelas
authors.forename: J J
authors.initials: JJ
authors.lastname: Nogal
authors.forename: R A
authors.initials: RA
authors.lastname: Martínez
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000994:Antitrichomonal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D051379:Mice; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014247:Trichomonas Vaginitis / Q000188:drug therapy / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D013829:Thiadiazines