title: How membrane proteins travel across the mitochondrial intermembrane space.
abstract: A newly discovered family of small proteins in the yeast mitochondrial intermembrane space mediates import of hydrophobic proteins from the cytoplasm into the inner membrane. Loss of one of these chaperone-like proteins from human mitochondria results in a disease that causes deafness, muscle weakness and blindness.
authors.affiliation: Dept of Biochemistry, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
authors.forename: C M
authors.initials: CM
authors.lastname: Koehler
authors.forename: S
authors.initials: S
authors.lastname: Merchant
authors.forename: G
authors.initials: G
authors.lastname: Schatz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D018832:Molecular Chaperones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D013577:Syndrome
chemical_list: D008565:Membrane Proteins; D018832:Molecular Chaperones