title: Anatomic segmentation of the intestinal immune response in nonhuman primates: differential distribution of B cells after oral and rectal immunizations to sites defined by their source of vascularization.
abstract: We show that the distribution of specific antibodies and antibody-secreting cells in the intestine after oral and rectal immunizations corresponds to the vascularization and lymph drainage patterns of the gut. Oral immunizations induce antibody responses along the parts of the intestine connected to the superior mesenteric vessels and lymph ducts, whereas rectal immunizations induce antibody responses along the parts of the intestine associated with the inferior mesenteric vessels and ducts.
authors.affiliation: Department of Medical Microbiology, University of Göteborg, Göteborg, Sweden. Kristina.Eriksson@microbio.gu.se
authors.forename: K
authors.initials: K
authors.lastname: Eriksson
authors.forename: M
authors.initials: M
authors.lastname: Quiding-Järbrink
authors.forename: J
authors.initials: J
authors.lastname: Osek
authors.forename: I
authors.initials: I
authors.lastname: Nordström
authors.forename: M
authors.initials: M
authors.lastname: Hjulström
authors.forename: J
authors.initials: J
authors.lastname: Holmgren
authors.forename: C
authors.initials: C
authors.lastname: Czerkinsky
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000285:Administration, Rectal; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology*; D007114:Immunization; D007422:Intestines / Q000098:blood supply / Q000276:immunology*; D008252:Macaca fascicularis