Failure of preventive effects of 2-deoxy-D-glucose on ischemia-induced gerbil hippocampal neuronal damage by induced hyperthermia.
Post-ischemic administration of 2-deoxy-D-glucose (2-DG), a glucose antimetabolite, markedly reduces the occurrence of ischemia-induced delayed neuronal death (DND) in the gerbil hippocampus. This means that the reduction of energy dependent metabolism after ischemia prevents ischemia-induced damages of hippocampal neurons. In the present study, we demonstrated hyperthermia during ischemia fails to preserve neurons in hippocampal CA1 of 2-DG treated gerbil following transient forebrain ischemia.
Hara
A
A
Department of Pathology, Gifu University School of Medicine, Gifu, Japan. ahara@cc.gifu-u.ac.jp
Niwa
M
M
Iwai
T
T
Yano
H
H
Nakashima
M
M
Bunai
Y
Y
Uematsu
T
T
Yoshimi
N
N
Mori
H
H
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D006979:Hyperthermia, Induced; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000473:pathology*
D000963:Antimetabolites; D003847:Deoxyglucose