title: Diabetic ketoacidosis precipitated by thyrotoxicosis.
abstract: We report two patients with type 1 diabetes mellitus, previously well controlled with good compliance, presenting with unexplained diabetic ketoacidosis. Following initial correction of the metabolic disorder, persisting tachycardia lead to the diagnosis of thyrotoxicosis. In both cases, treatment with propranolol and carbimazole helped in the stabilization of their metabolic states. Although thyrotoxicosis is known to destabilize diabetes control, we can find no reports of it precipitating diabetic ketoacidosis.
authors.affiliation: Diabetes Centre, North Manchester General Hospital, Crumpsall, Manchester, UK.
authors.forename: A
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: P G
authors.initials: PG
authors.lastname: Wiles
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D016883:Diabetic Ketoacidosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D011433:Propranolol / Q000627:therapeutic use; D013610:Tachycardia / Q000188:drug therapy; D013971:Thyrotoxicosis / Q000150:complications*
chemical_list: D000889:Anti-Arrhythmia Agents; D013956:Antithyroid Agents; D002231:Carbimazole; D011433:Propranolol