Translocation (10;11)(p13;p15) in an infant acute myeloid leukemia with MLL gene rearrangement.
Molecular rearrangements of the MLL gene at the 11q23 region have been identified in most cases of infant leukemia, regardless of the phenotype. We present a case of acute myeloid leukemia which coexpressed myeloid and lymphoid markers in a 12-month-old girl. Karyotype analysis revealed the presence of a thus far unreported translocation t(10;11)(p13;p15). Although no 11q23 abnormalities were cytogenetically detectable, an MLL gene molecular rearrangement was found.
Marco
F
F
Servicio de Hematología del Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Bureo
E
E
Delgado
M D
MD
Richard
C
C
Cuadrado
M A
MA
Pérez Retortillo
J A
JA
Recio
M
M
Zubizarreta
A
A
D000208:Acute Disease; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000235:genetics*; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase