Strategic pooling of compounds for high-throughput screening.
Bringing new medicines to the market depends on the rapid discovery of new and effective drugs, often initiated through the biological testing of many thousands of compounds in high-throughput screening (HTS). Mixing compounds together into pools for screening is one way to accelerate this process and reduce costs. This paper contains both theoretical and experimental data which suggest that careful selection of compounds to be pooled together is necessary in order to reduce the risk of reactivity between compounds within the pools.
Hann
M
M
Department of Biomolecular Structure, Glaxo Wellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire, U.K.
Hudson
B
B
Lewell
X
X
Lifely
R
R
Miller
L
L
Ramsden
N
N
D002853:Chromatography, Liquid; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000706:statistics & numerical data; D013058:Mass Spectrometry; D013329:Structure-Activity Relationship