title: [Therapeutic potential of glucocorticoids inhalation in bronchial asthma].
abstract: OBJECTIVE
  To assess effectiveness and safety of inhalation glucocorticoids (budesonide, beklometasone dipropionate) in bronchial asthma (BA).
  
  
  METHODS
  19 BA patients (8 males and 11 females) inhaled glucocorticoids for 9 months.
  
  
  RESULTS
  The treatment reduced the need in inhalation of short-acting beta-2-adrenomimetics, episodes of asphyxia occurred less frequently. A significant improvement of bronchial permeability was achieved only after 3 months of therapy. Blood levels of hydrocortisone, concentrations of magnesium, calcium and potassium in the serum, red cells and 24-h urine, serum osteocalcin, lumbar vertebral tissue density 3, 6 and 9 months after the treatment start were almost similar to the baseline.
  
  
  CONCLUSIONS
  Glucocorticoids for inhalation are clinically effective in BA. They should be used for not less than 3 months. Topical steroids in mean therapeutic doses had no negative effects on the levels of hydrocortisone, mineral metabolism and bone tissue.
authors.forename: A V
authors.initials: AV
authors.lastname: Emel'ianov
authors.forename: S E
authors.initials: SE
authors.lastname: Shevelev
authors.forename: V I
authors.initials: VI
authors.lastname: Amosov
authors.forename: B A
authors.initials: BA
authors.lastname: Murzin
authors.forename: S A
authors.initials: SA
authors.lastname: Shubin
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D001507:Beclomethasone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001980:Bronchi / Q000378:metabolism; D019819:Budesonide / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010539:Permeability; D011188:Potassium / Q000097:blood; D012129:Respiratory Function Tests; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D015675:Osteocalcin; D019819:Budesonide; D008274:Magnesium; D001507:Beclomethasone; D011188:Potassium; D002118:Calcium; D006854:Hydrocortisone