Possibility of inhibin as a regulator of androstenedione production by the ovary during the period of delayed ovulation in a vespertilionid bat, Scotophilus heathi.
The aim of the present study was to evaluate the role of inhibin in regulating androstenedione production by the ovary of Scotophilus heathi during the period of delayed ovulation. Inhibin alone increased the androstenedione synthesis in vitro by the ovary during all reproductive phases, but augmented the hCG induced androstenedione production only during November. The follicles produced significantly higher androstenedione as compared to the stromal or granulosa cell in response to both hCG and inhibin. However, inhibin augmented hCG stimulated androstenedione in the stromal cell only. Immunoreactivity of inhibin subtype alpha, betaA and betaB were mainly localized in the thecal and interstitial cell from September to November and then declined during the preovulatory period. However, in granulosa cells weak to moderate immunoreactivity of all inhibin subtype was observed during these phases. These results indicate the possible role of inhibin in regulating androstenedione synthesis by the ovary and thus. may be indirectly responsible for causing delayed ovulation in S. heathi.
Doval
J
J
Department of Zoology, Banaras Hindu University, Varanasi, India.
Krishna
A
A
D000735:Androstenedione / Q000096:biosynthesis*; D000818:Animals; D002685:Chiroptera / Q000378:metabolism*; D005260:Female; D005496:Follicular Atresia / Q000187:drug effects / Q000378:metabolism; D006107:Granulosa Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D007265:Inhibins / Q000494:pharmacology / Q000502:physiology*; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D010060:Ovulation / Q000378:metabolism*; D012621:Seasons
D000735:Androstenedione; D007265:Inhibins