Numerical simulation of motility patterns of the small bowel. II. Comparative pharmacological validation of a mathematical model.
A model of a locus of the small bowel, described earlier by the authors (Miftakhov et al., 1999) was validated in a comparison of the results of numerical simulations of pharmacological compounds to their effects in biological studies. The actions of the following four classes of drugs were simulated, those: (i) acting on the sarcoplasmic reticulum, (ii) altering the permeability of L- and T-type Ca(2+)channels on the smooth muscle membrane, (iii) motilides, and (iv) benzodiazepines. The strong qualitative resemblance between the theoretical and experimental results supports the robustness of the model.
Miftakhov
R N
RN
Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52246, USA.
Abdusheva
G R
GR
Christensen
J
J
D001569:Benzodiazepines / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003198:Computer Simulation; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects*; D008954:Models, Biological; D009037:Motilin / Q000494:pharmacology; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D012433:Ryanodine / Q000494:pharmacology
D002121:Calcium Channel Blockers; D001569:Benzodiazepines; D012433:Ryanodine; D009037:Motilin