title: Nonvasculitic autoimmune inflammatory meningoencephalitis (NAIM): a reversible form of encephalopathy.
abstract: Five patients, age 54 to 80 years, presented between 3 weeks and 18 months after symptomatic onset of progressive cognitive decline, psychosis, and unsteady gait that proved to be due to a steroid-responsive nonvasculitic autoimmune inflammatory meningoencephalitic syndrome. CSF examination showed elevated immunoglobulin (Ig)G index and IgG synthesis rate in all three patients in whom it was checked, and brain biopsy revealed perivascular lymphocytic infiltrates without vessel wall invasion.
authors.affiliation: Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Caselli
authors.forename: B F
authors.initials: BF
authors.lastname: Boeve
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: J D
authors.initials: JD
authors.lastname: O'Duffy
authors.forename: G G
authors.initials: GG
authors.lastname: Hunder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D001808:Blood Vessels / Q000473:pathology; D001921:Brain / Q000473:pathology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D007074:Immunoglobulin G