Liquid chromatography-nuclear magnetic resonance spectroscopy.
A general overview of the experimental set-up for performing analytical-scale and nanoliter-scale liquid chromatography-1H nuclear magnetic resonance spectroscopy (LC-1H-NMR) experiments is given. The high power of combining LC with 1H-NMR spectroscopy is demonstrated by two examples, where NMR acquisition was performed either in the continuous-flow mode on the analytical scale or in the stopped-flow mode on the nanoliter scale. Current developments employing the on-line coupling of capillary as well as supercritical fluid separation methods with 1H-NMR spectroscopy together with LC-13C-NMR spectroscopy are discussed.
Albert
K
K
Universität Tübingen, Institut für Organische Chemie, Germany. klaus.albert@uni-tuebingen.de
D002853:Chromatography, Liquid / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*