Are prostaglandins involved in atrial natriuretic peptide mechanisms of cardiovascular control?
Atrial natriuretic peptide (ANP) can excite cardiac nerve endings and invoke a decrease in arterial blood pressure and a reduction in renal sympathetic nerve activity. Our laboratory has previously demonstrated that this renal depressor reflex was invoked by systemic injection of ANP and not by the direct application of ANP to the epicardium, a major locus for vagal afferents. We now examine whether inhibition of prostaglandin synthesis impairs reflex responses that are normally associated with ANP injections. Renal sympathetic nerve activity, arterial blood pressure, and heart rate were recorded in anesthetized rats. Indomethacin was used to inhibit prostaglandin synthesis through the cyclooxygenase pathway. The ANP-mediated decrease in arterial blood pressure and renal sympathetic nerve activity, observed when prostaglandin synthesis was inhibited, did not differ significantly from the decreases observed in these parameters when prostaglandin synthesis was not inhibited. Heart rate remained unchanged. Our results suggest that the sympatho-inhibitory effects of ANP do not require prostaglandins as intermediary compounds.
Bandali
K S
KS
Department of Physiology, University of Toronto, ON, Canada.
Ackermann
U
U
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D051546:Cyclooxygenase 2; D006339:Heart Rate / Q000187:drug effects*; D007527:Isoenzymes / Q000502:physiology; D007668:Kidney / Q000294:innervation; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects
D007527:Isoenzymes; D011453:Prostaglandins; D009320:Atrial Natriuretic Factor; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases