title: Mechanism of overshoot in cardiac function during recovery from submaximal exercise in man.
abstract: BACKGROUND
  A sudden increase (overshoot) in the left ventricular ejection fraction during the recovery from maximal exercise has been reported in patients with coronary artery disease, but its mechanism has not been fully clarified. We investigated whether this phenomenon may occur in normal subjects, and whether it depends on the intensity of exercise.
  
  
  METHODS
  Thirteen normal subjects (mean [+/- SD] age, 59 +/- 8 years old) performed two levels (25 W and 50 W) of mild-intensity, constant-work-rate exercise for 6 min on a cycle ergometer. Left ventricular function was monitored continuously during the recovery from exercise using a computerized cadmium telluride detector.
  
  
  RESULTS
  An overshoot was observed in the ejection fraction during the first minute of recovery compared with the end-exercise value. The overshoot in the ejection fraction during recovery after the 50-W exercise was greater than that seen after the 25-W exercise. An overshoot phenomenon in stroke volume was also observed during the recovery from 50-W exercise.
  
  
  CONCLUSIONS
  The overshoot in cardiac function observed during the early phase of recovery, which was caused mainly by an immediate decrease in end-systolic volume, occurred even after exercise of mild intensity. This phenomenon appears to suggest the existence of a transient mismatch between cardiac contractility and afterload reduction during the recovery from mild-intensity exercise, even in normal subjects.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kano
authors.forename: A
authors.initials: A
authors.lastname: Koike
authors.forename: T
authors.initials: T
authors.lastname: Yajima
authors.forename: Y
authors.initials: Y
authors.lastname: Koyama
authors.forename: F
authors.initials: F
authors.lastname: Marumo
authors.forename: M
authors.initials: M
authors.lastname: Hiroe
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D012016:Reference Values; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*