title: Computational model of the effects of stochastic conditioning on the induction of long-term potentiation and depression.
abstract: The long-term potentiation (LTP) or long-term depression (LTD) of synaptic strength are currently considered to be the first microscopic steps leading to learning and memory. The great majority of experiments (both in vitro and in vivo) studying the basic mechanisms of LTP and LTD induction use conditioning protocols in which the presynaptic stimuli are delivered at constant frequencies. This is not, however, what is commonly found in vivo, where a highly irregular spiking activity seems to drive most of the neuronal functions. Thus, some important aspects of the induction characteristics of LTP and LTD expressed in vivo might have been overlooked by the experiments. Using a simple schematic model for a synapse we show here that, in fact, the statistical properties of a presynaptic conditioning signal could change the probability to induce LTP and/or LTD, suggesting a new and faster operating mode for a synapse.
authors.affiliation: Institute of Advanced Diagnostic Methodologies, National Research Council, Palermo, Italy. migliore@iaif.pa.cnr.it
authors.forename: M
authors.initials: M
authors.lastname: Migliore
authors.forename: P
authors.initials: P
authors.lastname: Lansky
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D017774:Long-Term Potentiation; D008954:Models, Biological; D013269:Stochastic Processes; D009435:Synaptic Transmission