[Dose the administration of low-dose aprotinin contribute to an anti-inflammatory effect in coronary artery bypass grafting?].
A study was conducted to determine whether the administration of low-dose aprotinin contributed to an anti-inflammatory effect in coronary artery bypass grafting. Levels of the inflammatory cytokines; IL-6, IL-8, and GEL, were measured before and after cardiopulmonary bypass, then 1, 3 and 6 days after coronary artery bypass grafting, in a group of patients given aprotinin (n = 7) and a control group (n = 15). A comparison of the levels of all these inflammatory cytokines between the two groups revealed no significant difference at any time point. This indicates, that low-dose aprotinin did not contribute to an anti-inflammatory effect in coronary artery bypass grafting.
Shirasawa
B
B
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.
Hamano
K
K
Gohra
H
H
Katoch
T
T
Fujimura
Y
Y
Zempo
N
N
Esato
K
K
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D007611:Aprotinin / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D019272:Leukocyte Elastase / Q000097:blood; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D007611:Aprotinin; D019272:Leukocyte Elastase