title: Solubility profiles of some isoxazolyl-naphthoquinone derivatives.
abstract: Water, ethanol and n-hexane solubility and pH-solubility behavior of a homologous series of isoxazolyl-naphthoquinone derivatives, which exhibit important biological activity, were studied. Their pK(a) values were determined spectrophotometrically as well as from their pH-solubility profiles. Also, the molar aqueous solubility of these compounds was estimated with the equations developed by Yalkowsky and Valvani using the data of their melting points and octanol/water partition coefficients.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Granero
authors.forename: M M
authors.initials: MM
authors.lastname: de Bertorello
authors.forename: M C
authors.initials: MC
authors.lastname: Briñón
mesh_terms: D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D000431:Ethanol / Q000737:chemistry; D006586:Hexanes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007555:Isoxazoles / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D000442:Octanols / Q000737:chemistry; D012995:Solubility; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D006586:Hexanes; D007555:Isoxazoles; D009284:Naphthols; D000442:Octanols; D014867:Water; C026385:n-hexane; D000431:Ethanol