title: Stereotactic irradiation of skull base meningiomas with high energy protons.
abstract: Nineteen patients with inextirpable skull base meningioma with involvement of neurovascular structures were given irradiation with a 180 MeV proton beam at the The Svedberg Laboratory, Uppsala, Sweden. The patients were treated seated in a fixed position with a stereotactic approach. Titanium-markers to the outer table served for identification and verification of the target positioning for dose planning and irradiation. The patients were given a total dose of 24 Gy in four consecutive daily 6 Gy fractions. All patients have been followed for at least 36 months. So far no meningiomas have progressed after treatment. Two patients have developed corticosteroid responsive oedema in the target area 6 moths after treatment. Late, but not serious, symptoms of side effects have been observed in one patient.
authors.affiliation: Department of Neurosurgery, University Hospital, Uppsala, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Gudjonsson
authors.forename: E
authors.initials: E
authors.lastname: Blomquist
authors.forename: G
authors.initials: G
authors.lastname: Nyberg
authors.forename: L
authors.initials: L
authors.lastname: Pellettieri
authors.forename: A
authors.initials: A
authors.lastname: Montelius
authors.forename: E
authors.initials: E
authors.lastname: Grusell
authors.forename: C
authors.initials: C
authors.lastname: Dahlgren
authors.forename: U
authors.initials: U
authors.lastname: Isacsson
authors.forename: A
authors.initials: A
authors.lastname: Lilja
authors.forename: B
authors.initials: B
authors.lastname: Glimelius
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008875:Middle Aged; D011522:Protons; D011859:Radiography; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D011882:Radiotherapy, High-Energy / Q000379:methods*; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
chemical_list: D011522:Protons