Antioxidants from Lespedeza homoloba. (I).
The stems of Lespedeza homoloba yielded eight new and three known phenolic compounds. Their structures have been elucidated on the basis of their spectral data. These compounds had strong antioxidative activity against lipid peroxidation in the rat brain homogenate test. 3,9-Dihydroxypterocarp-6a-en and lespedezol A2 showed significant antiallergic activity in allergic (type I) mice.
Miyase
T
T
School of Pharmaceutical Sciences, University of Shizuoka, Japan. miyase@ys7.u-shizuoka-ken.ac.jp
Sano
M
M
Nakai
H
H
Muraoka
M
M
Nakazawa
M
M
Suzuki
M
M
Yoshino
K
K
Nishihara
Y
Y
Tanai
J
J
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D007887:Fabaceae / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D013481:Superoxides / Q000378:metabolism
D018926:Anti-Allergic Agents; D000975:Antioxidants; D010636:Phenols; D013481:Superoxides