Two new cytotoxic carbonimidic dichlorides from the nudibranch Reticulidia fungia.
Two new sesquiterpenes, reticulidins A (1) and B (2), containing a rare functional group, N=CCl(2), have been isolated together with known congeners from the nudibranch Reticulidia fungia and their structures elucidated by spectroscopic data. Both 1 and 2 were cytotoxic against KB and L1210 cells.
Tanaka
J
J
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan. jtanaka@sci-u.ryukyu.ac.jp
Higa
T
T
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007094:Imides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D007094:Imides; C400157:reticulidia A; C400158:reticulidia B