title: Blood gases and sex hormones in women with and without genital descensus.
abstract: BACKGROUND
  Abnormalities in connective tissue and spirometric disorders have previously been found in women with genital descensus.
  
  
  OBJECTIVE
  To evaluate the association of descensus and respiratory function.
  
  
  METHODS
  The blood gases and sex hormones were measured in 130 women scheduled for surgical correction of descensus and 60 matched women without descensus. All subjects were nonsmokers and without past or present cardiorespiratory disease.
  
  
  RESULTS
  Women with descensus had a lower pH (7.39+/-0.04 vs. 7.41+/-0.04, p = 0.01), lower arterial tensions of oxygen (12.7+/-12. vs. 14.1+/-0.9 kPa, p = 0.003) and carbon dioxide (5.1+/-0.4 vs. 5.3+/-0.3 kPa) but a higher hemoglobin concentration (141+/-11 vs. 132+/-9 g/l) and a higher serum progesterone in the follicular phase of the cycle (3.1+/-4 vs. 1.5+/-1 ng/ml, p = 0.03). In 39 (30%) women with descensus, the arterial carbon dioxide tension was below 4.9 kPa. All subjects ventilated more in the luteal compared to the follicular phase of the cycle. In women with descensus, the hemoglobin concentration increased with decreasing arterial oxygen tension (p = 10(-4)) and with decreasing pH (p<10(-3)).
  
  
  CONCLUSIONS
  Women with descensus frequently hyperventilate and, compared with women without descensus, have a lower arterial oxygen tension, increased hemoglobin concentration and slightly lower pH.
authors.affiliation: Department of Biomedical Physics, Medical School in Split, Croatia. fizast@alf.tel.hr
authors.forename: D
authors.initials: D
authors.lastname: Eterović
authors.forename: T
authors.initials: T
authors.lastname: Strinić
authors.forename: Z
authors.initials: Z
authors.lastname: Dujić
authors.forename: M
authors.initials: M
authors.lastname: Boban
mesh_terms: D002245:Carbon Dioxide / Q000097:blood*; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000150:complications / Q000503:physiopathology; D005260:Female; D005498:Follicular Phase; D005831:Genital Diseases, Female / Q000150:complications / Q000503:physiopathology*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006985:Hyperventilation / Q000150:complications / Q000503:physiopathology*; D008183:Luteal Phase; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D017698:Postmenopause; D017697:Premenopause; D011391:Prolapse; D014549:Urinary Incontinence / Q000150:complications / Q000503:physiopathology; D014596:Uterine Prolapse / Q000150:complications / Q000503:physiopathology*
chemical_list: D012739:Gonadal Steroid Hormones; D002245:Carbon Dioxide; D010100:Oxygen