Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation.
Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.
Juji
T
T
Japanese Red Cross Central Blood Center, Tokyo.
Watanabe
Y
Y
Ishikawa
Y
Y
Fujiwara
K
K
Tonami
H
H
Tanaka
H
H
Satake
M
M
Akaza
T
T
Tadokoro
K
K
Kodera
Y
Y
Sasazuki
T
T
Morishima
Y
Y
Takaku
F
F
D016824:Antigens, Human Platelet / Q000235:genetics*; D016026:Bone Marrow Transplantation / Q000276:immunology* / Q000401:mortality; D018572:Disease-Free Survival; D000939:Epitopes / Q000235:genetics; D005838:Genotype; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000628:therapy; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D012189:Retrospective Studies; D013997:Time Factors
C071092:5a alloantigen, human; C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D000939:Epitopes; D015778:Minor Histocompatibility Antigens