title: Effectiveness of radiation therapy in nephrotic syndrome associated with advanced lung cancer.
abstract: Paraneoplastic nephrotic syndrome is rare, bur occurs mostly in lung cancer. The glomerular lesion usually exhibits membranous nephropathy. Although surgical therapy has been shown to be effective, the treatment of a paraneoplastic nephrotic syndrome has always been a challenge. Currently no standard therapy has been established, if the paraneoplastic nephrotic syndrome is associated with advanced cancer with unresectable lesions. We present 2 cases having paraneoplastic nephrotic syndrome associated with advanced squamous cell carcinoma of the lung. Radiation therapy of the primary tumor effectively caused regression of the paraneoplastic nephrotic syndrome without affecting the renal function. Our results suggest that irradiation can be the first choice in the treatment of nephrotic syndrome, if the primary tumor is unresectable.
authors.affiliation: Department of Medicine III, Okayama University Medical School, Okayama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shikata
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Shikata
authors.forename: H
authors.initials: H
authors.lastname: Makino
mesh_terms: D000368:Aged; D004487:Edema / Q000532:radiotherapy; D015433:Glomerulonephritis, Membranous / Q000000981:diagnostic imaging / Q000209:etiology / Q000532:radiotherapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000532:radiotherapy*; D010257:Paraneoplastic Syndromes / Q000532:radiotherapy; D011507:Proteinuria / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed