title: Long-term functional morbidity after mild hyperthermic isolated limb perfusion with melphalan.
abstract: OBJECTIVE
  To assess long-term functional morbidity in patients entered in the prospective randomized EORTC trial investigating the role of adjuvant isolated limb perfusion (ILP) with melphalan for high-risk primary melanoma.
  
  
  METHODS
  In 65 patients (ILP 36, wide excision only 29), limb circumference and joint mobility measurements were performed on the treated and the contralateral limb after a mean interval of 48 months after primary treatment. The two treatment groups were comparable regarding age, sex distribution, percentage of skin grafts or regional lymph-node dissections, and interval between primary treatment and physical measurements.
  
  
  RESULTS
  None of the patients had severe complaints of the treated limb at the time of analysis. The ankle suffered most from ILP, with a statistical significant restricted extension in approximately 40% of the perfused patients. Abduction of the shoulder was minimally affected in treated upper limbs, probably as a result from the formation of scar tissue after axillary lymph-node dissection. Although no significant differences could be demonstrated in the circumference of upper or lower limbs, atrophy was seen in 24% of perfused lower limbs. Of the five perfused patients who developed oedema, four had also undergone a regional lymph-node dissection.
  
  
  CONCLUSIONS
  This risk of long-term functional morbidity should be weighed against the possible advantages of ILP in patients with limb melanoma or sarcoma.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute (Antoni van Leeuwenhoek ziekenhuis), Amsterdam, The Netherlands.
authors.forename: B C
authors.initials: BC
authors.lastname: Vrouenraets
authors.forename: G J
authors.initials: GJ
authors.lastname: in't Veld
authors.forename: O E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: G W
authors.initials: GW
authors.lastname: van Slooten
authors.forename: J A
authors.initials: JA
authors.lastname: van Dongen
authors.forename: B B
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects*; D001132:Arm; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects* / Q000379:methods; D005060:Europe; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007866:Leg; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000009:adverse effects*; D008875:Middle Aged; D011446:Prospective Studies; D016059:Range of Motion, Articular; D012720:Severity of Illness Index
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan