[Cytomegalovirus and arterial disease. Current aspects].
The cytomegalovirus (CMV) is the only microbial agent implicated in three particular types of arterial disease: coronary disease of the transplanted heart, post-angioplasty restenosis and atherosclerosis. The object of this article is to analyse the recent data on the role of CMV in these pathologies with an exhaustive review of the literature. The available data is mainly epidemiological but the interpretation is difficult because of the multiplicity and imperfections of the diagnostic techniques of the infection. However, the results are quite concordant in favour of a real association. Different physiopathological mechanisms are proposed. In coronary disease of the transplanted heart, the lesions could be initiated by an inflammatory process. In post-angioplasty restenosis, the virus seems able to trigger cellular proliferation by inhibiting the mechanisms of apoptosis. Finally, in atherosclerosis, CMV infection seems to promote atherothrombotic processes and accelerate the progression of atherosclerotic plaques by activating inflammatory cells. Direct methods of detection of viral DNA show the presence of the virus within these lesions. There is, therefore, epidemiological, anatomo-pathological and physiopathological evidence in favour of a relationship between CMV infection and these three forms of arterial disease.
Lozinguez
O
O
Centre de recherche Claude-Bernard sur les maladies vasculaires, Paris.
Arnaud
E
E
Velut
J G
JG
Tiev
K P
KP
Fiessinger
J N
JN
Emmerich
J
J
D017130:Angioplasty / Q000009:adverse effects*; D001161:Arteriosclerosis / Q000601:surgery*; D003327:Coronary Disease / Q000601:surgery*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006083:Graft Occlusion, Vascular / Q000821:virology*; D016027:Heart Transplantation; D006801:Humans; D011183:Postoperative Complications / Q000821:virology