title: [Treatment of idiopathic thrombocytopenic purpura in adults: efficacy of domestic intravenous immunoglobulin in immune thrombocytopenia].
abstract: OBJECTIVE
  The study of effectiveness of intravenous immunoglobulin (IVIG) in therapy of idiopathic thrombocytopenic purpura (ITP) in adults.
  
  
  METHODS
  High doses of IVIG (0.2-0.4 g/kg b.w. for 4-6 days) were given to 6 female patients aged 20 to 59 years (median--39 years) with immune thrombocytopenia. 4 patients had primary ITP resistant to glucocorticosteroids (GCS) and 1 female had chronic ITP treated by splenectomy without effect. 1 patient with rheumatoid arthritis developed severe thrombocytopenia combined with agranulocytosis when treated with nonsteroid antiinflammatory drugs.
  
  
  RESULTS
  The response was observed in 5 of 6 patients (in 4 patients resistant to GCS and 1 RA patient). In 3 of them the effect was rated as excellent (platelets level > 150,000 per cubic millimeter), in 2 patients it was good (platelets count from 50,000 to 150,000 per cubic millimeter). Splenectomy was performed in 4 cases with ITP on day 8-14 after IVIG therapy. The 2- and 6-month follow-up evidenced for good results of the surgical treatment. The RA patient showed a stable rise of the blood count. Serious side effects of IVIG therapy were not registered.
  
  
  CONCLUSIONS
  IVIG of Russian produce is effective in the treatment of drug-induced thrombocytopenia and ITP resistant to GCS.
authors.forename: S A
authors.initials: SA
authors.lastname: Pugina
authors.forename: N M
authors.initials: NM
authors.lastname: Evdokimova
authors.forename: G G
authors.initials: GG
authors.lastname: Rastorguev
authors.forename: O S
authors.initials: OS
authors.lastname: Samoĭlova
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: G V
authors.initials: GV
authors.lastname: Sidnev
authors.forename: D M
authors.initials: DM
authors.lastname: Vasil'ev
authors.forename: V V
authors.initials: VV
authors.lastname: Anastasiev
authors.forename: O V
authors.initials: OV
authors.lastname: Milovidova
authors.forename: E V
authors.initials: EV
authors.lastname: Molodovskaia
authors.forename: N N
authors.initials: NN
authors.lastname: Borovkov
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy*; D012426:Russia; D013156:Splenectomy; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous