The effect of the chain length of polynucleotides on their binding with platinum complexes.
The effect of the length of polynucleotides on their binding with platinum complexes was studied. The highest reaction rate was observed in the reaction with guanosine-containing polynucleotides, whereas cytidine- and adenosine-containing polynucleotides were much less efficient. The monoaqua-forms of the platinum complexes exhibited the highest reactivity in the interaction with polynucleotides in solution. The mechanism implies the formation of the monodentate complex at the first stage which is transformed into the corresponding bidentate complex of chelate type at the second stage. Increase in the length of the polynucleotide chain was shown to enhance its interaction with the platinum complexes.
Stefanov
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VE
Department of Biochemistry, St. Petersburg State University, Russia. kutin@hq.bio.lgu.spb.su
Tulub
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Kutin
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D000225:Adenine / Q000737:chemistry; D002945:Cisplatin / Q000737:chemistry / Q000378:metabolism*; D003596:Cytosine / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D018736:DNA Adducts / Q000737:chemistry / Q000378:metabolism; D006147:Guanine / Q000737:chemistry; D007554:Isotopes; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010984:Platinum / Q000737:chemistry; D011119:Polynucleotides / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D018736:DNA Adducts; D007554:Isotopes; D011119:Polynucleotides; D010984:Platinum; D006147:Guanine; D003596:Cytosine; D004247:DNA; D000225:Adenine; D002945:Cisplatin