Peroxiredoxin I expression in human thyroid tumors.
Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves' disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P = 0.00005) and thyroiditis group (P = 0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance. Immunohistochemistry indicated that Prx I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.
Yanagawa
T
T
Division of Head and Neck Surgery, Chiba Cancer Center Hospital, Japan.
Ishikawa
T
T
Ishii
T
T
Tabuchi
K
K
Iwasa
S
S
Bannai
S
S
Omura
K
K
Suzuki
H
H
Yoshida
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015151:Immunoblotting; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010544:Peroxidases / Q000032:analysis*; D054464:Peroxiredoxins; D017382:Reactive Oxygen Species / Q000378:metabolism; D013961:Thyroid Gland / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000737:chemistry*; D013966:Thyroiditis / Q000378:metabolism; D013974:Thyroxine / Q000096:biosynthesis
D000975:Antioxidants; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D010544:Peroxidases; D054464:Peroxiredoxins; D013974:Thyroxine