Repetitive hydatidiform mole with different male partners.
OBJECTIVE
The aim of this study was to determine the role of parental factors that may relate to the pathogenesis of molar pregnancy.


METHODS
A retrospective review of six patients who had a molar pregnancy with at least two different partners at New England Trophoblastic Disease Center between 1965 and March 1999 was performed.


RESULTS
A total of 34 pregnancies with 20 different partners were observed in 6 patients. These pregnancies resulted in 15 (44.1%) hydatidiform moles, 8 (23.5%) term live births, 7 (20.6%) therapeutic abortions, 3 (8.8%) spontaneous abortions, and 1 preterm delivery. While 5 patients had a molar pregnancy with 2 different partners, 1 patient had a molar pregnancy with 3 different partners. Two patients developed persistent postmolar gestational trophoblastic tumor in 3 (20.0%) of the 15 episodes of molar pregnancy. Three of the male partners reported a total of 7 healthy children from prior relationships.


CONCLUSIONS
The experience in these six patients suggests that a primary oocyte problem may contribute to the development of molar pregnancy.
Tuncer
Z S
ZS
Gillette Center for Women's Cancers, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Bernstein
M R
MR
Wang
J
J
Goldstein
D P
DP
Berkowitz
R S
RS
D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology*; D008297:Male; D011247:Pregnancy; D012189:Retrospective Studies; D012747:Sexual Partners; D014594:Uterine Neoplasms / Q000453:epidemiology*