title: Lipid peroxidation and antioxidant state after laparoscopic and open cholecystectomy.
abstract: OBJECTIVE
  To measure the amount of lipid peroxidation and erythrocyte antioxidation in patients undergoing laparoscopic and open cholecystectomy and healthy controls.
  
  
  METHODS
  Non-randomised study.
  
  
  METHODS
  University hospital, Istanbul.
  
  
  METHODS
  31 patients, of whom 14 underwent open and 17 laparoscopic cholecystectomy, and 15 healthy controls.
  
  
  METHODS
  Heparinised blood samples were taken from the patients immediately after operation and from the healthy controls.
  
  
  METHODS
  Lipid peroxidation index as expressed by thiobarbituric-acid-reactive substances (TBARS) and components of the erythrocyte antioxidant defence system, namely reduced glutathione, reduced glutathione peroxidase (glutathione-Px) and CuZn superoxide dismutase (CuZn SOD) in patients undergoing open or laparoscopic cholecystectomy and healthy controls.
  
  
  RESULTS
  All 4 variables were significantly higher in the cholecystectomy groups than in controls (p < 0.001), and laparoscopic cholecystectomy caused significantly less oxidative stress than the open operation (p < 0.001).
  
  
  CONCLUSIONS
  Both types of cholecystectomy cause oxidative stress and lead to an adaptive antioxidant response in the body. However; both oxidative stress and the antioxidant response are more pronounced after traditional open cholecystectomy.
authors.affiliation: Department of Surgery, Istanbul Medical Faculty, Istanbul University, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Seven
authors.forename: A
authors.initials: A
authors.lastname: Seven
authors.forename: Y
authors.initials: Y
authors.lastname: Erbil
authors.forename: S
authors.initials: S
authors.lastname: Mercan
authors.forename: G
authors.initials: G
authors.lastname: Burçak
mesh_terms: D016022:Case-Control Studies; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood*; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione