title: A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N).
abstract: We report herein the identification of a new HLA-A null allele. This allele, A*0105N, was detected during histocompatibility testing of a cord blood donor and the respective mother. Serologic typing results contrasted those obtained with DNA typing that alone showed the presence of HLA-A*01. ThisA*0105N was due to a nucleotide deletion in exon 4 that altered the reading frame, causing a premature termination.
authors.affiliation: Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy. nitpmi@polic.cilea.it
authors.forename: F
authors.initials: F
authors.lastname: Poli
authors.forename: P
authors.initials: P
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: Scalamogna
authors.forename: L
authors.initials: L
authors.lastname: Crespiatico
authors.forename: N
authors.initials: N
authors.lastname: Ghidoli
authors.forename: G
authors.initials: G
authors.lastname: Puglisi
authors.forename: G
authors.initials: G
authors.lastname: Sirchia
mesh_terms: D000483:Alleles; D001483:Base Sequence; D004247:DNA; D005091:Exons / Q000235:genetics*; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D017384:Sequence Deletion
chemical_list: D015234:HLA-A Antigens; C403924:HLA-A*01:04N antigen; D015788:HLA-A1 Antigen; D004247:DNA