title: [Fibrinogen and lipids: associated risk factors for ischemic cerebral stroke].
abstract: The study included 55 patients (18 females, 37 males); aged 32-75 yr. who divided into three groups according to the severity of clinical picture: 12 people with reversible ischaemic stroke (RIS), 20 with progressive ischaemic stroke (PIS), 23 with complete stroke (CS). Levels of total cholesterol, high density lipoproteins (HDL), apolipoproteins A1 and B (ApoA1 and ApoB), fibrinogen (Fb) and Lp (a) were measured. Lipid factor of atherosclerosis (ATHi) was quantified. Qualitative evaluation of lipids contents in cerebrospinal fluid (CSR) was performed. Distribution of cholesterol--containing lipids among the fractions, despite low values, had clearly atherogenic profile. 12% patients with irreversible ischaemic stroke, 16% with progressive ischaemic stroke and 85% with complete stroke had Fb level above 4 g/l. Lp (a) levels in all cases were significantly higher in the cells isolated from CSF. The severity of the stroke correlated with increasing levels of lipids in the cells isolated from SF. There was correlation between LDL cholesterol and content of lipids in the cells from CSF.
authors.affiliation: Katedry i Kliniki Neurologii PAM w Szczecinie.
authors.forename: K
authors.initials: K
authors.lastname: Honczarenko
authors.forename: B
authors.initials: B
authors.lastname: Torbus-Lisiecka
authors.forename: Z
authors.initials: Z
authors.lastname: Osuch
authors.forename: D
authors.initials: D
authors.lastname: Nocoń
authors.forename: P
authors.initials: P
authors.lastname: Nowacki
authors.forename: A
authors.initials: A
authors.lastname: Potemkowski
authors.forename: A
authors.initials: A
authors.lastname: Narolewska
mesh_terms: D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D008055:Lipids; D005340:Fibrinogen