[Pigmented pemphigoid].
BACKGROUND
Pigmented bullous pemphigoid has many clinical manifestations. We report a pigmented erythematous form with disseminated bullae.


METHODS
A 70-year-old woman with a history of breast adenocarcinoma developed an eruption of pigmented macules on the trunk and members of 72 hour duration. At five days, there was an eruption of tight bullae. The diagnosis of bullous pemphigoid was retained because of the association of infraepidermic bullae, linear deposits of C3 along the basal membrane and the presence of the 180 kDa minor bullous pemphigoid antigen on immunoblotting.


CONCLUSIONS
The initial pigmented aspect of this bullous pemphigoid suggested disseminated pigmented bullous erythema, but histology data with immunotransfer corrected the diagnosis. This very atypical presentation led us to look for a particular etiology. There was no argument in favor of a malignancy in this patient in complete remission after treatment of her breast adenocarcinoma. The fact that the patient was phototype IV would probably explain the pigmented nature of the initial lesions.
Poulain
J F
JF
Service de Dermatologie et Vénéréologie, CHRU, Amiens.
Carmi
E
E
Thelu
F
F
Lok
C
C
Denoeux
J P
JP
D000368:Aged; D001324:Autoantigens / Q000032:analysis; D001485:Basement Membrane / Q000473:pathology; D003176:Complement C3 / Q000032:analysis; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D015151:Immunoblotting; D010391:Pemphigoid, Bullous / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000473:pathology; D012880:Skin Pigmentation
D001324:Autoantigens; D003176:Complement C3