Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties.
Straight chain compounds having a phenylisoserine unit and an oxetane ring at the alpha- and omega- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.
Fuji
K
K
Institute for Chemical Research, Kyoto University, Japan.
Watanabe
Y
Y
Ohtsubo
T
T
Nuruzzaman
M
M
Hamajima
Y
Y
Kohno
M
M
D000438:Alcohols / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004988:Ethers, Cyclic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000737:chemistry*; D012694:Serine / Q000031:analogs & derivatives* / Q000737:chemistry; D014404:Tubulin / Q000737:chemistry
D000438:Alcohols; D000972:Antineoplastic Agents, Phytogenic; D004988:Ethers, Cyclic; D014404:Tubulin; D012694:Serine; C010286:beta-phenylisoserine; C005287:oxetane; D017239:Paclitaxel