[Transfusion-related lung injury edema].
BACKGROUND
Transfusion-related acute lung injury (TRALI) is a relatively rare but potentially severe complication of blood transfusion that should be diagnosed.


METHODS
The origin of this complication is most often an immunological leucocyte conflict due to transfused plasma HLA antibodies. Prevention (anti-HLA antibody screening in blood donors and elimination of blood products from immunized donors) is discussed.


CONCLUSIONS
Transfusion-related acute lung injury should be suspected in transfusion-related respiratory distress, after elimination of potential pulmonary edema due to overloading. An immunologic cause should always be searched for. Leukodepletion of blood products and harmonization in blood donor selection should prevent this rare complication.
Fruchart
M F
MF
ETS AP-HP, Hôtel-Dieu, Paris, France.
Klaren
J
J
Belhocine
R
R
Ben Hadj Amor
H
H
D000208:Acute Disease; D000328:Adult; D001782:Blood Donors; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D011247:Pregnancy; D011654:Pulmonary Edema / Q000209:etiology* / Q000276:immunology / Q000517:prevention & control; D012131:Respiratory Insufficiency / Q000209:etiology; D065227:Transfusion Reaction
D006680:HLA Antigens; D007518:Isoantibodies