Pharmacogenomics: translating functional genomics into rational therapeutics.
Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution.
Evans
W E
WE
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. williams.evans@stjude.org
Relling
M V
MV
D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D011955:Receptors, Drug / Q000235:genetics / Q000378:metabolism
D002352:Carrier Proteins; D004364:Pharmaceutical Preparations; D011955:Receptors, Drug