title: Glaucoma surgery: are there new perspectives in perioperative pharmacology?
abstract: The literature directed at perioperative pharmacologic advances in relation to glaucoma filtration surgery is reviewed. The successful use of subconjunctival anesthesia demonstrates a new alternative in preoperative glaucoma surgical anesthesia. The intraoperative use of the antimetabolites mitomycin C and 5-fluorouracil in both traditional filtration and glaucoma drainage implantation surgery has been expanded. The use of the antifibrinolytic agents urokinase and recombinant tissue plasminogen activator adds a new and controversial dimension to postoperative pharmacologic therapy.
authors.affiliation: Devers Eye Institute, Legacy Health Care System, Portland, OR 97210, USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Donohue
authors.forename: G A
authors.initials: GA
authors.lastname: Cioffi
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D018463:Filtering Surgery; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D016685:Mitomycin / Q000627:therapeutic use*
chemical_list: D000963:Antimetabolites; D005343:Fibrinolytic Agents; D016685:Mitomycin; D005472:Fluorouracil