Ontogeny of nitric oxide synthase I and III protein expression and enzymatic activity in the guinea pig hippocampus.
60. NOS enzymatic activity increased throughout prenatal and postnatal life, and attained highest activity in the adult. The developmental profile of NOS III protein expression was similar to that for NOS enzymatic activity. There was differential expression of NOS I protein, which was low in the GD 50 fetus and increased rapidly during fetal development to attain adult level by GD 62. These data suggest that the guinea pig is a reliable animal model in which to investigate the roles of NO in normal hippocampal development and in mediating neuronal injury in this brain region.
Kimura
K A
KA
Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Reynolds
J N
JN
Brien
J F
JF
D000818:Animals; D001835:Body Weight / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology; D006168:Guinea Pigs; D006624:Hippocampus / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III; D009929:Organ Size / Q000502:physiology
D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052250:Nitric Oxide Synthase Type III