title: [The genotype-based haplotype relative risk and transmission disequilibrium test analyses of familial febrile convulsions].
abstract: OBJECTIVE
  To confirm the linkage of familial febrile convulsions to the short arm of chromosome 6(6p) or the long arm of chromosome 8(8q).
  
  
  METHODS
  The authors finished genotyping of Pst I locus on the coding region of heat shock protein (HSP) 70, 5'untranslated region of HSP70-1, 3' untranslated region of HSP70-2, D8S84 and D8S85. The data were processed by the genotype-based haplotype relative risk(GHRR) and transmission disequilibrium test(TDT) methods in PPAP.
  
  
  RESULTS
  Some signs of association and disequilibrium between D8S85 and FC were shown by GHRR and TDT.
  
  
  CONCLUSIONS
  A suspect linkage of familial febrile convulsions to the long arm of chromosome 8 has been proposed.
authors.affiliation: Department of Pediatrics, The First Teaching Hospital of Beijing Medical University, Beijing, 100034 P. R. China. pedlab@public.east.cn.net
authors.forename: Y
authors.initials: Y
authors.lastname: Qi
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: Z
authors.initials: Z
authors.lastname: Guo
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Pan
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Bao
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.forename: L
authors.initials: L
authors.lastname: Zou
authors.forename: Q
authors.initials: Q
authors.lastname: Lin
mesh_terms: D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D012306:Risk; D003294:Seizures, Febrile / Q000235:genetics*