[Frequency of sex chromosome nondisjunction as affected by microtubule destabilization and heat shock in various lines of Drosophila melanogaster].
Vinblastine (Vb), a drug belonging to a group of mitotic poisons, was shown to induce sexual chromosome nondisjunction and loss (SCNL) in oogenesis of different strains of Drosophila melanogaster. Heat shock (37 degrees C, 45 min) decreases the frequency of these events. The highest level of nondisjunction was demonstrated in the temperature-sensitive strain both after heat shock and Vb treatment. No increase of SCNL frequency in oocytes of females treated with griseofulvin (Gf) and Colchicine (Cl), analogues of Vb.
Shvartsman
P Ia
PIa
Russian State Pedagogical University, Department of Genetics and Breeding, St. Petersburg, Russia.
Isaenko
O A
OA
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D005260:Female; D006118:Griseofulvin / Q000494:pharmacology; D018869:Heat-Shock Response / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis / Q000187:drug effects; D009630:Nondisjunction, Genetic; D009866:Oogenesis / Q000502:physiology; D012730:Sex Chromosomes; D013045:Species Specificity; D014747:Vinblastine / Q000494:pharmacology
D006118:Griseofulvin; D014747:Vinblastine; D003078:Colchicine