title: A comprehensive view of human chromosome 1.
abstract: Comprehensive representations of human chromosomes combining diverse genomic data sets, localizing expressed sequences, and reflecting physical distance are essential for disease gene identification and sequencing efforts. We have developed a method (CompView) for integrating genomic information derived from available cytogenetic, genetic linkage, radiation hybrid, physical, and transcript-based mapping approaches. CompView generates chromosome representations with substantially higher resolution, coverage, and integration than current maps of the human genome. The CompView process was used to build a representation of human chromosome 1, yielding a map with >13,000 unique elements, an effective resolution of 910 kb, and a marker density of 50 kb. CompView creates comprehensive and fully integrated depictions of a chromosome's clinical, biological, and structural information.
authors.affiliation: Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 USA. white@genome.chop.edu
authors.forename: P S
authors.initials: PS
authors.lastname: White
authors.forename: E P
authors.initials: EP
authors.lastname: Sulman
authors.forename: C J
authors.initials: CJ
authors.lastname: Porter
authors.forename: T C
authors.initials: TC
authors.lastname: Matise
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D018244:Chromosomes, Artificial, Yeast; D002878:Chromosomes, Human, Pair 1; D016208:Databases, Factual; D020224:Expressed Sequence Tags; D008040:Genetic Linkage; D005819:Genetic Markers; D016678:Genome; D006801:Humans; D018895:Microsatellite Repeats; D008957:Models, Genetic; D020161:Physical Chromosome Mapping; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D005819:Genetic Markers; D012333:RNA, Messenger