Necrobiotic cutaneous T-cell lymphoma.
We report 3 patients with granulomatous cutaneous T-cell lymphoma (CTCL) who showed necrobiosis histologically with palisading granulomas. Although granulomatous change may be present in up to 4% of cases of CTCL, necrobiosis is rare. Misdiagnosis may occur if epidermotropism is minimal or if atypical cells are masked by the granulomatous infiltrate. T-cell receptor gene analysis confirmed the presence of clonal T-cell populations in lesional skin from all 3 cases.
Woollons
A
A
St John's Institute of Dermatology, St Thomas's Hospital, London, United Kingdom.
Darvay
A
A
Khorshid
S M
SM
Whittaker
S
S
Jones
R R
RR
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis; D017441:Necrobiotic Disorders / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*