[Evaluation of dissolution behavior for the products containing tegafur and uracil].
Generic drugs are widely used with the object of cost saving in many Japanese therapeutic scenes now. The products containing the same active ingredient(s), even if they are innovative drugs or generic ones, must be designed to possess the equivalent quality. In this report, we observed the dissolution behavior patterns of three generic drugs that contain Tegafur and Uracil, drugs A, B, and C, and compared them with that of an innovative product, UFT. Drugs B and C were similar to UFT in the dissolution rate of Tegafur, but drug A was not. On the dissolution rate of Uracil, all the generic products, drugs A, B and C, did not amount to the level equivalent to that of UFT. Therefore, these generic products did not indicate the same dissolution behavior pattern as UFT. It was suggested that the pharmaceutical technology used in the manufacture was not equivalent even if the products of the same dosage form contain the same kind and content of the active ingredient(s).
Azuma
M
M
Department of Pharmacy, University Hospital, School of Medicine, University of Tokushima, Japan.
Ichimaru
K
K
Ishiki
K
K
Umeda
T
T
Shono
F
F
Kujime
T
T
Houchi
H
H
Minakuchi
K
K
D002214:Capsules; D004338:Drug Combinations; D016568:Drugs, Generic; D012995:Solubility; D005641:Tegafur / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*
D002214:Capsules; D004338:Drug Combinations; D016568:Drugs, Generic; D005641:Tegafur; D014498:Uracil