Inhibition of neutrophil apoptosis by verotoxin 2 derived from Escherichia coli O157:H7.
In order to evaluate the pathological role of verotoxin 2 (VT2), we investigated the effects of VT2 on neutrophil apoptosis in vitro. The results showed that VT2 caused a significant delay in spontaneous neutrophil apoptosis and that the effect was abrogated by a protein kinase C inhibitor. These data indicate that longer survival of neutrophils may aggravate neutrophil-mediated tissue damage in VT2-associated diseases.
Liu
J
J
Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa 228-8555, Japan.
Akahoshi
T
T
Sasahana
T
T
Kitasato
H
H
Namai
R
R
Sasaki
T
T
Inoue
M
M
Kondo
H
H
D017209:Apoptosis / Q000187:drug effects*; D001427:Bacterial Toxins / Q000633:toxicity*; D053938:DNA Fragmentation; D004768:Enterotoxins / Q000633:toxicity*; D019453:Escherichia coli O157 / Q000472:pathogenicity*; D006358:Hot Temperature; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D022622:Shiga Toxin 1; D022641:Shiga Toxin 2; D019311:Staurosporine / Q000494:pharmacology
D001427:Bacterial Toxins; D004768:Enterotoxins; D022622:Shiga Toxin 1; D022641:Shiga Toxin 2; D019311:Staurosporine