Binding of pili from uropathogenic Escherichia coli to membranes secreted by human colonocytes and enterocytes.
PapG adhesins mediate the binding of uropathogenic Escherichia coli. Although receptors for these adhesins have not been demonstrated in intestinal epithelia, the colonic microflora includes strains of uropathogenic E. coli. We now report that surfactant-like particles secreted by the human intestine contain receptors for PapG adhesins and may provide an intestinal habitat for uropathogenic bacteria.
Goetz
G S
GS
Department of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.
Mahmood
A
A
Hultgren
S J
SJ
Engle
M J
MJ
Dodson
K
K
Alpers
D H
DH
D018830:Adhesins, Escherichia coli / Q000502:physiology*; D001422:Bacterial Adhesion; D003106:Colon / Q000382:microbiology*; D020895:Enterocytes / Q000382:microbiology*; D004926:Escherichia coli / Q000502:physiology*; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial / Q000502:physiology*; D006801:Humans; D014552:Urinary Tract Infections / Q000382:microbiology*
D018830:Adhesins, Escherichia coli; C092426:PapG protein, E coli; D036781:Fimbriae Proteins