Insights into the structure, distribution and function of the cardiac chloride channels.
This review describes the properties and distribution of the three major types of chloride currents that have been studied in cardiac tissue. These include a cAMP- and protein kinase A-dependent current, a calcium-activated current and a swelling-induced current. The study of cardiac anion currents is a less mature field than the study of cardiac cation currents. Consequently, less is known regarding the structure, molecular identity and physiological role of anion currents in comparison to cardiac cation currents. Where known, the available molecular and structural information is also discussed. Although there is no proven physiological role for cardiac chloride currents, the possible clinical electrophysiological roles of cardiac chloride currents are discussed.
Sorota
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Department of Pharmacology, Columbia University, New York, NY 10032, USA. ss47@columbia.edu
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D001693:Biological Transport, Active; D018118:Chloride Channels / Q000235:genetics / Q000378:metabolism*; D004594:Electrophysiology; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D017136:Ion Transport; D009200:Myocardial Contraction / Q000502:physiology*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D018118:Chloride Channels