title: Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics.
abstract: Chondroid lipoma is a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its histopathologic features may resemble hibernoma, myxoid liposarcoma, myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In this study, a chondroid lipoma was analyzed by fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and metaphase fluorescence in situ hybridization. The results demonstrate that chondroid lipoma exhibits a characteristic pattern by fine-needle aspiration cytology, including a mixture of benign adipose tissue with lipoblastlike cells, and chondroblastlike cells with a fibrochondroid matrix. Cytogenetically, a three-way rearrangement between chromosomes 1, 2, and 5 was found, together with an 11;16 translocation with a breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region shown to be rearranged frequently in hibernoma. The presence of a karyotype of low complexity, but without any of the genetic aberrations characteristic for other types of soft-tissue tumors, indicate that chondroid lipoma develops along a unique pathogenetic pathway.
authors.affiliation: Department of Clinical Genetics, University Hospital, Lund, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Gisselsson
authors.forename: H A
authors.initials: HA
authors.lastname: Domanski
authors.forename: M
authors.initials: M
authors.lastname: Höglund
authors.forename: B
authors.initials: B
authors.lastname: Carlén
authors.forename: F
authors.initials: F
authors.lastname: Mertens
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D002356:Cartilage / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D002871:Chromosome Banding; D020223:Chromosome Painting; D002877:Chromosomes, Human; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008854:Microscopy, Electron; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic
chemical_list: D004273:DNA, Neoplasm