title: Indomethacin for 3 days is not effective as prophylaxis for heterotopic ossification after primary total hip arthroplasty.
abstract: Although indomethacin is effective in preventing heterotopic ossification (HO) after total hip arthroplasty (THA) when used for 8 to 14 days, side effects are frequently observed. We conducted a prospective, nonrandomized pilot study of prophylaxis for HO in THA using indomethacin for 3 days. We used a 2-stage design for phase 2 clinical data, based on earlier studies in our department. Our study group consisted of 19 patients, of whom 14 (74%) developed HO; 7 (37%) showed grade 1, 4 (21%) grade II, and 3 (15.8%) grade III according to the Brooker classification. We compared these results with 2 historic control groups; one group received indomethacin for 7 days, and the other group received no prophylaxis. We did not see any reduction of the ossification relative to the group that received no prophylaxis. Indomethacin for 3 days seems not to be sufficient to prevent HO.
authors.affiliation: Department of Orthopaedics, University Hospital of Nijmegen, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: van der Heide
authors.forename: R T
authors.initials: RT
authors.lastname: Koorevaar
authors.forename: B W
authors.initials: BW
authors.lastname: Schreurs
authors.forename: A
authors.initials: A
authors.lastname: van Kampen
authors.forename: A
authors.initials: A
authors.lastname: Lemmens
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control*; D015207:Osteoarthritis, Hip / Q000601:surgery; D010865:Pilot Projects; D011446:Prospective Studies; D017211:Treatment Failure
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin