[Long-term results of comprehensive treatment for cervical cancer with poor prognosis].
The data on a randomized treatment of 100 patients with locally advanced cervical carcinoma are discussed. Half of the patients received complex therapy while the rest--radiation alone (control). The modality also included immunotherapy with epithalamin 100 mg, intramuscularly, neoadjuvant intraarterial polychemotherapy with 5-fluorouracil 2 g/m2 and cisplatin 100 mg/m2, concurrent radiotherapy with an interval and 4-6 courses of adjuvant polychemotherapy. As a consequence, short-term results improved by 18.8% in cases tumor size under T3; end-results--by 14%. Improvement in survival was accounted for by causing tumor process to slow down considerably. The adjuvant polychemotherapy component was thought to be responsible for a 25.4% increase in one-year survival and 12.5%--in 3-year survival.
Vishnevskaia
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N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Ministry of Health of the Republic of Belarus, Minsk.
Kosenko
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D010455:Peptides / Q000627:therapeutic use*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D000276:Adjuvants, Immunologic; D010455:Peptides; C027437:epithalamin; D002945:Cisplatin; D005472:Fluorouracil