[The participation of glutaminergic transmission in the mechanism of movement disorders induced by reverse rotation in white mice].
Administration of MK-801 or IEM-1754 prevented akinesia in mice induced by reversing rotation, not less effectively than scopolamine. Quaternary adamantane derivative IEM-1857 was ineffective. IEM-1925 enhanced the locomotor disturbance induced by reversing rotation due, probably, to different spectrum of its antiglutamate action. The data obtained suggest involvement of glutamate synaptic transmission in development of locomotor disturbances of a vestibular origin.
Lukomskaia
N Ia
NIa
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, Russia.
Zhabko
E P
EP
Gmiro
V E
VE
D000218:Adamantane / Q000031:analogs & derivatives; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D012399:Rotation / Q000009:adverse effects*; D012601:Scopolamine / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
D018691:Excitatory Amino Acid Antagonists; D018727:Muscarinic Antagonists; D017470:Receptors, Glutamate; D016291:Dizocilpine Maleate; D012601:Scopolamine; D000218:Adamantane