title: Comparison of outcomes research with clinical trials using preexisting data.
abstract: Outcomes research using analysis of preexisting data is a relatively new field with the potential to improve the quality and effectiveness of medical care, and may provide a useful complement to randomized studies. Motivated by the growth of this research in the cardiovascular literature, this review offers a framework to identify the core concepts of outcomes research from database analyses by comparing and contrasting it with the randomized clinical trial.
authors.forename: J G
authors.initials: JG
authors.lastname: Canto
authors.forename: C I
authors.initials: CI
authors.lastname: Kiefe
authors.forename: O D
authors.initials: OD
authors.lastname: Williams
authors.forename: H V
authors.initials: HV
authors.lastname: Barron
authors.forename: W J
authors.initials: WJ
authors.lastname: Rogers
mesh_terms: D015982:Bias; D002309:Cardiology; D015984:Causality; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D003625:Data Collection; D016208:Databases, Factual; D004992:Ethics, Medical; D006302:Health Services Research; D006801:Humans; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic; D012107:Research Design