title: Assessment of goiter in an area of endemic iodine deficiency.
abstract: Urinary iodone (UI) excretion and sonographically measured thyroid volume were investigated in 195 subjects living in 6 separate villages in the Casamance region of southeastern Senegal, West Africa. A comparison of goiter prevalence using thyroid palpation and volume measurement and of iodine excretion expressed as micrograms per gram (microg/g) creatinine or micrograms per deciliter (microg/dl) urine was undertaken, and possible pathogenetic factors were investigated. Ultrasound measured thyroid volumes were above the recommended upper limit of the reference range for an area replete in iodine in 83.1% or females, 52.3% of males, and 80.0% of children aged 13 years or younger. Overall sensitivity and specificity for palpation compared to sonographically demonstrated thyroid enlargement was 51.7% and 91.5%, respectively. Thyroid enlargement was not associated with ethnic origin, thiocyanate ingestion, HLA DR/DQ phenotype frequency, or thyroid growth-stimulating immunoglobulin (TGI) positivity. Median UI was 32 microg/g creatinine with 65.0% having values consistent with iodine deficiency (< 50 microg/g). When results were expressed as micrograms per deciliter, the percentage having values consistent with iodine deficiency (< 5.0 microg/dl) increased to 95.7%. The findings suggest a primary role for iodine deficiency in goitrogenesis in the study population. They demonstrate that classification of the severity of the endemia in this or other study populations in areas of iodine deficiency is dependent on the methods used to determine goiter prevalence (palpation or ultrasound measured thyroid enlargement), or dietary iodine status (iodine excretion expressed as micrograms per gram creatinine or micrograms per deciliter urine).
authors.affiliation: Endocrine Laboratory, Department of Medicine and Therapeutics, University College Dublin, Ireland. ppa.smyth@ucd.ie
authors.forename: P P
authors.initials: PP
authors.lastname: Smyth
authors.forename: C
authors.initials: C
authors.lastname: Darke
authors.forename: A B
authors.initials: AB
authors.lastname: Parkes
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: John
authors.forename: A M
authors.initials: AM
authors.lastname: Hetherton
authors.forename: J H
authors.initials: JH
authors.lastname: Lazarus
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity; D005260:Female; D006043:Goiter, Endemic / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010173:Palpation; D012675:Senegal / Q000453:epidemiology; D013861:Thiocyanates / Q000652:urine; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D013861:Thiocyanates; D007455:Iodine