title: Anoxia/induced membrane changes in human red blood cells.
abstract: The cation-osmotic hemolysis was studied in human red blood cells incubated under anoxic conditions. In relation to the time course of anoxia, two phases of hemolysis were distinguished. A significant decrease of hemolysis was found between 3 and 24 h of incubation. On the other hand, hemolysis was significantly increased after prolonged incubation (48-72 h). Using the method of cation-osmotic hemolysis, the properties of two membrane constituents, spectrine membrane skeleton and membrane bilayer, were studied. The relation between cation-osmotic hemolysis and erythrocyte deformability is being discussed.
authors.affiliation: Department of Pharmacology, Medical Faculty, Safárik University, Slovak Republic. mojzis@central.medic.upjs.sk
authors.forename: A
authors.initials: A
authors.lastname: Nicák
authors.forename: J
authors.initials: J
authors.lastname: Mojzis
authors.forename: M
authors.initials: M
authors.lastname: Jandoseková
authors.forename: L
authors.initials: L
authors.lastname: Mirossay
mesh_terms: D004910:Erythrocyte Membrane / Q000473:pathology*; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D006461:Hemolysis; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000473:pathology*