[The effect of perftoran on the morphofunctional status of the digestive system organs in experimental duodenal ulcer].
The authors studied the effect of perftoran (PF) on the morpho-functional parameters of alimentary system organs (ASO) (liver, pancreas, stomach, duodenum, and small intestine) in rats with experimental chronic acetate duodenal ulcer. Inflammatory-infiltrative and dystrophic changes were found in the ASO tissues which led to activation of the enzymes superoxide dismutase and catalase in their homogenates. PF pharmacotherapy reduces the inflammatory-infiltrative changes in the ASO tissues and normalizes the enzyme systems of antioxidant protection.
Karimov
Kh Ia
KhIa
2nd Tashkent Medical Institute, Uzbekistan.
Daminov
Sh N
ShN
Khoroshaev
V A
VA
D000085:Acetates; D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004064:Digestive System / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D005466:Fluorocarbons / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051381:Rats; D013997:Time Factors
D000085:Acetates; D001802:Blood Substitutes; D005466:Fluorocarbons; C063334:perftoran