title: Effect of latanoprost on regional blood flow and capillary permeability in the monkey eye.
abstract: OBJECTIVE
  To evaluate the effects of latanoprost on regional blood flow and capillary permeability in the monkey eye.
  
  
  METHODS
  Anesthetized cynomolgus monkeys were unilaterally treated with a single dose containing 6 pg of latanoprost; or 10 microg of PhXA34 (13,14-dihydro-15R, S-17-phenyl-18,19,20-trinor-prostaglandin F2alpha [PGF2alpha]-isopropyl ester), which contains about 50% latanoprost. Regional blood flow in the eye was measured with radioactively labeled microspheres; capillary permeability was measured by determining the extravascular plasma-equivalent albumin space using 125I-albumin, 131I-albumin, and 51Cr-labeled erythrocytes.
  
  
  RESULTS
  Latanoprost or PhXA34 had no or only a slight effect on the regional blood flow when measured 1, 2 1/2, 3, 4 1/2, and 6 hours after dose administration, with the exception of the anterior sclera, in which a moderate increase in blood flow was detected. No effect on capillary permeability to albumin was detected when studied 30 minutes to 2 1/2 hours and 5 to 6 hours after dose administration.
  
  
  CONCLUSIONS
  Latanoprost, a selective prostaglandin F receptor agonist, exerted no or only slight vascular effects for up to 6 hours after dose administration in the monkey eye, with the exception of the anterior sclera, in which a moderate increase in blood flow was detected.
  
  
  CONCLUSIONS
  Naturally occurring prostaglandins may cause marked microcirculatory changes in the eye that could be of clinical concern. Latanoprost, a selective prostaglandin F receptor agonist, seems to be devoid of such effects.
authors.affiliation: Department of Neuroscience, Unit of Pharmacology, Uppsala University, Sweden. Johan.Stjernschantz@neuro.uu.se
authors.forename: J
authors.initials: J
authors.lastname: Stjernschantz
authors.forename: G
authors.initials: G
authors.lastname: Selén
authors.forename: M
authors.initials: M
authors.lastname: Astin
authors.forename: M
authors.initials: M
authors.lastname: Karlsson
authors.forename: B
authors.initials: B
authors.lastname: Resul
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D005123:Eye / Q000098:blood supply* / Q000187:drug effects; D005260:Female; D000077338:Latanoprost; D008252:Macaca fascicularis; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008863:Microspheres; D009883:Ophthalmic Solutions / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost