title: Longitudinal follow-up of the intellectual and academic functioning of children receiving central nervous system-prophylactic chemotherapy for leukemia: a four-year final report.
abstract: This longitudinal investigation extends our prospective study of the intellectual and academic functioning of children treated for cancer to 4 years after diagnosis. In the longer term, the children who received central nervous system (CNS) chemotherapy experienced greater neurocognitive deficits, particularly in the area of academic achievement, than did the children who did not receive CNS chemotherapy. Specifically, the CNS chemotherapy-treated children scored lower on academic tests of reading at 3 and 4 years after diagnosis. The results suggest that CNS chemotherapy prophylaxis may adversely effect the development of higher-order mental abilities and cognitive skills during the late-effects period and may also impair academic achievement.
authors.affiliation: Department of Pediatrics, Medical University of South Carolina, Charleston 29425, USA. brownron@musc.edu
authors.forename: R T
authors.initials: RT
authors.lastname: Brown
authors.forename: M G
authors.initials: MG
authors.lastname: Sawyer
authors.forename: G
authors.initials: G
authors.lastname: Antoniou
authors.forename: I
authors.initials: I
authors.lastname: Toogood
authors.forename: M
authors.initials: M
authors.lastname: Rice
mesh_terms: D000124:Achievement; D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011446:Prospective Studies; D012720:Severity of Illness Index
chemical_list: D000970:Antineoplastic Agents