title: Organic leachables from polymer-based dental filling materials.
abstract: Results are reported from a study on the in vitro separation and identification of leachables from three different polymer-based dental filling materials by using a combined method of gas chromatography and mass spectrometry. The median number of separable organic leachables in these materials was between 14 and 22. Of these organic leachables the following were identified and quantified: DL-camphorquinone, 4-dimethylaminobenzoic acid ethyl ester (DMABEE), drometrizole, 1,7,7-trimethylbicyclo[2,2,1]heptane, 2,2-dimethoxy[1,2] diphenyletanone (DMBZ), ethyleneglycol dimethacrylate (EGDMA), and triethyleneglycol dimethacrylate (TEGDMA). Three of the leachables have previously been shown to provoke allergy. The range of log P(ow) values (representing the lipophilicity of these compounds) varied between 1.09 and 4.20. By multivariate data analysis, selected leachables from the tested materials were shown to separate into characteristic patterns. The results contribute to a characterization of potential hazardous compounds in polymer-based dental filling materials.
authors.affiliation: Department of Odontology-Dental Biomaterials, University of Bergen, Norway. henning.lygre@odont.uib.no
authors.forename: H
authors.initials: H
authors.lastname: Lygre
authors.forename: P J
authors.initials: PJ
authors.lastname: Høl
authors.forename: E
authors.initials: E
authors.lastname: Solheim
authors.forename: G
authors.initials: G
authors.lastname: Moe
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D020770:Compomers / Q000737:chemistry; D003188:Composite Resins / Q000737:chemistry; D003764:Dental Materials / Q000737:chemistry*; D003793:Dental Restoration, Permanent; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008689:Methacrylates / Q000737:chemistry; D015999:Multivariate Analysis; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry; D062366:para-Aminobenzoates
chemical_list: C401765:2,2-dimethoxy(1,2)diphenyletanone; D001713:Biphenyl Compounds; D001643:Bridged Bicyclo Compounds; D020770:Compomers; D003188:Composite Resins; D003764:Dental Materials; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; C113049:Solitaire composite resin; D013729:Terpenes; D014230:Triazoles; D062366:para-Aminobenzoates; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; C082069:bornylene; C048339:camphoroquinone; C401764:drometrizole; C004919:ethylene dimethacrylate; C030747:ethyl 4-dimethylaminobenzoate; D010129:4-Aminobenzoic Acid