Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7.
We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.
Franti
M
M
Laboratoire de Virologie, C.E.R.V.I., UPRES EA 2387, Hôpital Pitié-Salpétrière, 75651 Paris Cedex 13, France.
Aubin
J T
JT
Gautheret-Dejean
A
A
Malet
I
I
Cahour
A
A
Huraux
J M
JM
Agut
H
H
D000483:Alleles; D002213:Capsid / Q000235:genetics; D005814:Genes, Viral; D014644:Genetic Variation; D006566:Herpesviridae Infections / Q000821:virology*; D016199:Herpesvirus 7, Human / Q000235:genetics*; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics
D010750:Phosphoproteins; D014759:Viral Envelope Proteins; C105061:glycoprotein B, human herpesvirus 7