title: [Nicotinamide in combined treatment of chronic pancreatitis].
abstract: OBJECTIVE
  To evaluate effects of nicotinamide on insulin secretion in glucose tolerance test and on blood clotting in patients with chronic pancreatitis (CP).
  
  
  METHODS
  30 patients with CP of alcoholic etiology received combined treatment with enzyme medicines. In addition, some of them were administered nicotinamide as 2.5% solution for 2 weeks (1 ml twice a day). Before the treatment and during its course, measurements were made of fasting and post glucose test values of insulin secretion and thromboelastogram.
  
  
  RESULTS
  Both basal and stimulated insulin secretion in CP patients was low compared to control subjects. Nicotinamide significantly increased basal secretion of insulin and insignificantly aroused its glucose-stimulated secretion. Nicotinamide promoted reduction of hypercoagulation and time to remission.
  
  
  CONCLUSIONS
  Nicotinamide administration is thought valid for correction of endocrine pancreatic function and hemocoagulation in patients with alcoholic CP.
authors.forename: A S
authors.initials: AS
authors.lastname: Loginov
authors.forename: B N
authors.initials: BN
authors.lastname: Matiushin
authors.forename: O V
authors.initials: OV
authors.lastname: Astaf'eva
authors.forename: T V
authors.initials: TV
authors.lastname: Nilova
authors.forename: L V
authors.initials: LV
authors.lastname: Vinokurova
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D019512:Pancreatitis, Alcoholic / Q000097:blood / Q000188:drug therapy*; D011863:Radioimmunoassay; D012074:Remission Induction; D013916:Thrombelastography; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D005765:Gastrointestinal Agents; D007328:Insulin; D009536:Niacinamide