title: Successful tracheocarinal transplantation.
abstract: BACKGROUND
  When extensive portions of the trachea and carina are resected, grafting is required.
  
  
  METHODS
  Two experiments were performed in dogs to assess the feasibility of extensive tracheocarinal replacement using short-segment tracheocarinal autografts, only to avoid the immunologic complexity of allografts. To determine the effect of tension on graft survival, extensive tracheal defects (12 to 18 rings) were created in four animals. These were subsequently reconstructed using 6-ring autografts. In the second experiment, three animals underwent excision of a maximal length of trachea determined in experiment 1 including the carina. Long-term viability of each graft was assessed using bronchoscopy and histologic examination.
  
  
  RESULTS
  The limit of tracheal resection successfully reconstructed using a 6-ring autograft was 14 rings (experiment 1). The tracheal grafts in which the tension was greater than 1.2 kg did not maintain their structural integrity. All of the autografts in experiment 2 were subjected to a tension of less than 1.0 kg at the anastomoses, and showed long-term viability.
  
  
  CONCLUSIONS
  We conclude that extensive tracheal and carinal defects may be successfully reconstructed using short-segment tracheocarinal grafts if the anastomoses are subjected to less than 1.0 kg of tension.
authors.affiliation: Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Nakanishi
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: So
authors.forename: M
authors.initials: M
authors.lastname: Sugaya
authors.forename: K
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D000818:Animals; D004285:Dogs; D006085:Graft Survival / Q000502:physiology*; D009852:Omentum / Q000473:pathology / Q000637:transplantation; D013536:Suture Techniques; D013908:Thoracotomy; D014132:Trachea / Q000473:pathology / Q000637:transplantation*; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology