title: Percutaneous sonography-guided fine needle aspiration biopsy of colonoscopic biopsy-negative colonic lesions.
abstract: BACKGROUND
  Pre-operative tissue diagnosis with colonoscopy is not always possible in patients with colonic lesions.
  
  
  OBJECTIVE
  To study the usefulness and efficacy of percutaneous ultrasound-guided aspiration biopsy of colonic lesions.
  
  
  METHODS
  Fifty consecutive patients with colonic lesions in whom colonoscopic brush cytology and biopsy were either negative or the lesion was not accessible on colonoscopy on two attempts, underwent percutaneous ultrasound-guided fine-needle aspiration biopsy. The results were compared with surgical findings.
  
  
  RESULTS
  Fine-needle aspiration biopsy revealed adenocarcinoma in 40 patients; one had lymphoma, 2 had tuberculosis, 2 had abscess and 5 patients had negative aspiration. Forty-eight patients (excluding 2 with tuberculosis) underwent laparotomy and the diagnoses on aspiration biopsy were confirmed. Of the 5 negative aspirations, 3 had adenocarcinoma, one had tuberculosis and one intussusception. Thus, we had sensitivity of 91.8%, specificity of 100%, predictive value of positive results 100%, predictive value of negative results 20%, and percentage of false negative results 8.1%. Two patients developed complications--hemorrhage into the peritoneum and sepsis due to perforation at the site of aspiration; both survived after surgery.
  
  
  CONCLUSIONS
  Percutaneous ultrasound-guided aspiration biopsy may be attempted for diagnosis of colonic lesions in situations where it may be the only means of obtaining a cytological diagnosis before surgery.
authors.affiliation: Department of Gastroenterology, Sher-e-Kashmir Institute of Medical Sciences, Soura, Srinagar.
authors.forename: G
authors.initials: G
authors.lastname: Javid
authors.forename: G M
authors.initials: GM
authors.lastname: Gulzar
authors.forename: B
authors.initials: B
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D001707:Biopsy, Needle / Q000379:methods; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014463:Ultrasonography