title: Antioxidant activity of tannin components from Vaccinium vitis-idaea L.
abstract: Reactive oxygen molecules have been implicated as important pathological mediators in many clinical disorders and periodontal disease. To provide possible alternative treatment of periodontal disease, six tannins isolated from Vaccinium vitis-idaea L. were evaluated for anti-lipid peroxidation, anti-superoxide formation and free radical scavenging activity. The results showed that cinnamtannin B1 displayed the strongest anti-lipid peroxidation activity, proanthocyanidin A-1 displayed the strongest superoxide scavenging activity, and epicatechin-(4beta--> 6)-epicatechin-(4beta-->8, 2beta-->O--> 7)-catechin had the strongest anti-superoxide formation effect. We conclude that tannins isolated from V. vitis-idaea L. exhibited multiple antioxidant activity, and could be used for the treatment of periodontal disease.
authors.affiliation: Graduate Institute of Dental Sciences and Department of Periodontics, Kaohsiung Medical College, Japan.
authors.forename: K Y
authors.initials: KY
authors.lastname: Ho
authors.forename: J S
authors.initials: JS
authors.lastname: Huang
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: T C
authors.initials: TC
authors.lastname: Lin
authors.forename: Y F
authors.initials: YF
authors.lastname: Hsu
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D010510:Periodontal Diseases / Q000517:prevention & control; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D017382:Reactive Oxygen Species; D013329:Structure-Activity Relationship; D013481:Superoxides; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D013634:Tannins; D013481:Superoxides; D014969:Xanthine Oxidase