title: Impact of Helicobacter pylori infection on serum gastrin in haemodialysis patients.
abstract: BACKGROUND
  Helicobacter pylori infection is associated with increased gastrin release in patients with normal renal function. Hypergastrinaemia is a common finding in haemodialysis patients and, in many cases, may be linked to H. pylori infection. The aim of this study was to examine the effect of H. pylori infection, and its eradication, on elevated gastrin levels in haemodialysis patients.
  
  
  METHODS
  Eighty-nine dyspeptic patients were included in the study. While 44 patients had normal renal function, the remaining 45 were end-stage renal failure patients. Patients were assigned to one of four groups according to their H. pylori and renal function status. Infected patients were re-evaluated after 2 months following eradication treatment. Serum gastrin levels were measured in these groups both before and after eradication treatment.
  
  
  RESULTS
  Haemodialysis patients with H. pylori infection had higher serum gastrin levels than did H. pylori negative haemodialysis patients (321+/-131 pg/ml vs 154+/-25 pg/ml) (P<0.05). Mean serum gastrin concentration was 152+/-21 pg/ml in the non-uraemic H. pylori-positive group. This value was 58+/-17 pg/ml in the non-uraemic H. pylori-negative group (P<0.05). There were significant decreases in serum gastrin levels from pre- to post-eradication of H. pylori in the infected haemodialysis and non-uraemic patient groups (312+/-131 pg/ml to 179+/-85 pg/ml and 152+/-21 pg/ml to 72+/-2.4 pg/ml respectively, P<0.05). Four patients in group Ib and 5 patients in group IIb who had persistent infection did not have a decrease in serum gastrin level. All patients with successful eradication had a decrease in serum gastrin concentration.
  
  
  CONCLUSIONS
  Our findings suggest that H. pylori infection contributes to hypergastrinaemia in haemodialysis patients. More research is needed regarding the clinical consequences of hypergastrinaemia in these individuals.
authors.affiliation: Gastroenterology Department, Biochemistry Division and Nephrology Department, Baskent University, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Gür
authors.forename: S
authors.initials: S
authors.lastname: Boyacioglu
authors.forename: C
authors.initials: C
authors.lastname: Gül
authors.forename: M
authors.initials: M
authors.lastname: Turan
authors.forename: M
authors.initials: M
authors.lastname: Gürsoy
authors.forename: C
authors.initials: C
authors.lastname: Baysal
authors.forename: N
authors.initials: N
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D008297:Male; D006435:Renal Dialysis
chemical_list: D000900:Anti-Bacterial Agents; D005755:Gastrins