title: Markov chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation.
abstract: We describe a Markov Chain Monte Carlo analysis of five human Y- chromosome microsatellite polymorphisms based on samples from five diverse populations. Our analysis provides strong evidence for mutational bias favoring increase in length at all loci. Estimates of population coalescent times and population size from our two largest samples, one African and one European, suggest that the African population is older but smaller and that the English East Anglian population has undergone significant expansion, being larger but younger. We conclude that Markov Chain Monte Carlo analysis of microsatellite haplotypes can uncover information not apparent when the microsatellites are considered independently. Incorporation of population size as a variable should allow us to estimate the timing and magnitude of major historical population trends.
authors.affiliation: Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Cooper
authors.forename: N J
authors.initials: NJ
authors.lastname: Burroughs
authors.forename: D A
authors.initials: DA
authors.lastname: Rand
authors.forename: D C
authors.initials: DC
authors.lastname: Rubinsztein
authors.forename: W
authors.initials: W
authors.lastname: Amos
mesh_terms: D000465:Algorithms; D000483:Alleles; D004739:England; D019143:Evolution, Molecular; D006239:Haplotypes; D006801:Humans; D007558:Italy; D007564:Japan; D008297:Male; D008390:Markov Chains; D018895:Microsatellite Repeats; D009010:Monte Carlo Method; D009154:Mutation; D009549:Nigeria; D013019:South Africa; D014998:Y Chromosome