[Inhibin and ovarian cancer].
Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.
Burger
H G
HG
Prince Henry's Institute of Medical Research, Victoria, Australia.
Baillie
A
A
Drummond
A E
AE
Healy
D L
DL
Jobling
T
T
Mamers
P
P
Robertson
D M
DM
Susil
B
B
Cahir
N
N
Shen
Y
Y
Verity
K
K
Fuller
P J
PJ
Groome
N P
NP
Findlay
J K
JK
D002288:Adenocarcinoma, Mucinous / Q000097:blood; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018284:Cystadenocarcinoma, Serous / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000097:blood*; D008875:Middle Aged; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010051:Ovarian Neoplasms / Q000097:blood* / Q000235:genetics; D017698:Postmenopause; D011962:Receptors, FSH / Q000235:genetics
D014408:Biomarkers, Tumor; C029152:G-substrate; D009419:Nerve Tissue Proteins; D011962:Receptors, FSH; D007265:Inhibins