title: A 5-year clinical evaluation of Norplant implants in Senegal.
abstract: The principal objective of this 5-year clinical study of Norplant implants was to introduce these implants into the family planning program in Senegal and to determine their overall acceptability and safety in Senegalese acceptors. A total of 300 subjects were enrolled into the trial from August 1986 to July 1991. All the women were followed-up for 5 years or until the implants were removed. The pooled cumulative discontinuation rate was 40.8 +/- 2.91 per 100 women resulting in a continuation rate of 59.2 +/- 2.91 per 100 women. Thirteen subjects (4.3%) were lost during the follow-up. Seven pregnancies were reported throughout the 5 years leading to a cumulative pregnancy rate of 3.3 +/- 1.25 per 100 women. Menstrual problems were the reason most often given for early removal during the first 2 years. After year 2, desire for another pregnancy was the main reason for implant removal. The results presented in this study show that the Norplant implant system is a safe, effective, and acceptable method that meets the needs of the Senegalese family planning program.
authors.affiliation: Gynecology and Obstetrics Clinic, University Teaching Hospital Le Dantec, Dakar, Senegal.
authors.forename: M G
authors.initials: MG
authors.lastname: Ba
authors.forename: J C
authors.initials: JC
authors.lastname: Moreau
authors.forename: D
authors.initials: D
authors.lastname: Sokal
authors.forename: R
authors.initials: R
authors.lastname: Dunson
authors.forename: B
authors.initials: B
authors.lastname: Dao
authors.forename: D
authors.initials: D
authors.lastname: Kouedou
authors.forename: F
authors.initials: F
authors.lastname: Diadhiou
mesh_terms: D000328:Adult; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000009:adverse effects; D004343:Drug Implants; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000009:adverse effects; D008599:Menstruation Disturbances / Q000139:chemically induced; D017060:Patient Satisfaction; D011247:Pregnancy; D011446:Prospective Studies; D012675:Senegal
chemical_list: D003271:Contraceptive Agents, Female; D004343:Drug Implants; D016912:Levonorgestrel