title: The human homolog of Sex comb on midleg (SCMH1) maps to chromosome 1p34.
abstract: Polycomb group genes were originally identified in Drosophila as repressors required to maintain the silenced state of homeotic loci. About ten Polycomb group genes have been cloned in Drosophila, and mammalian homologs have been identified for most of these. Here, we isolate cDNAs encoding two isoforms of a human homolog of Drosophila Sex comb on midleg (Scm), named Sex comb on midleg homolog-1 (SCMH1). Overall, SCMH1 has 94% identity to its mouse counterpart Scmh1, and 41% identity to Scm, and contains two 1(3)mbt domains, and the SPM domain that are characteristic of Scm. SCMH1 is widely expressed in adult tissues, and maps to chromosome 1p34.
authors.affiliation: Chiron Corporation, Emeryville, CA 94608-2916, USA.
authors.forename: J
authors.initials: J
authors.lastname: Berger
authors.forename: H
authors.initials: H
authors.lastname: Kurahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Takihara
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: H W
authors.initials: HW
authors.lastname: Brock
authors.forename: F
authors.initials: F
authors.lastname: Randazzo
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D006801:Humans; D019476:Insect Proteins / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D063150:Polycomb Repressive Complex 1; D063146:Polycomb-Group Proteins; D020033:Protein Isoforms; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C066770:Pc protein, Drosophila; D063146:Polycomb-Group Proteins; D020033:Protein Isoforms; D012097:Repressor Proteins; C099357:SCM protein, Drosophila; D063150:Polycomb Repressive Complex 1