HLA-DQ1 associated with reflex sympathetic dystrophy.
Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The frequency of HLA-DQ1 was found to be significantly increased compared with control frequencies. The association provides an indication for an organic basis of RSD.
Kemler
M A
MA
Department of Surgery, Maastricht University Hospital, The Netherlands.
van de Vusse
A C
AC
van den Berg-Loonen
E M
EM
Barendse
G A
GA
van Kleef
M
M
Weber
W E
WE
D006683:HLA-DQ Antigens / Q000276:immunology*; D006801:Humans; D012019:Reflex Sympathetic Dystrophy / Q000276:immunology*
D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen