title: Co-distribution of sensory gating and impaired niacin flush response in the parents of schizophrenics.
abstract: Complex illnesses may result from the interaction or addition of multiple factors. We examined the familial co-distribution of two abnormalities common in schizophrenia: impaired auditory sensory gating and impaired flush response to niacin. In ten families, the obligate carrier parent had sensory-gating deficits, while eight of the ten parents without a family history of schizophrenia had impaired flush response. No parents had both deficits. The data are consistent with a theory suggesting the interaction of these two factors in some cases of schizophrenia.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences and Denver Veteran's Administration Medical Center, 80262, USA. Merilyne.Waldo@UCHSC.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Waldo
mesh_terms: D005072:Evoked Potentials, Auditory; D005483:Flushing / Q000235:genetics*; D006801:Humans; D009525:Niacin / Q000494:pharmacology*; D010290:Parents; D010468:Perceptual Disorders / Q000175:diagnosis* / Q000235:genetics*; D012559:Schizophrenia / Q000378:metabolism*
chemical_list: D009525:Niacin