[The evaluation of the bioavailability of isosorbide 5-mononitrate].
The aim of this study was to investigate the bioavailability of isosorbide mononitrate (IS-5MN) after oral administration of Monocard 20 mg-capsules, made in "Synteza" â Pharmaceutical-Chemical Company in Poznań. Effox 20 mg, coated tablets from Schwarz Pharma, was used as an counterpart of Monocard 20 mg. The concentrations of IS-5MN in healthy volunteers' plasma were determined by using Hewlett Packard gas chromatography.


CONCLUSIONS
The bioavailability of IS-5MN after oral administration of Monocard 20 mg is the same as after oral administration of Effox 20 mg, whose clinical efficacy was tested before. This conclusion confirms the same value of AUC, tmax, cmax and other pharmacokinetic parameters of Monocard 20 mg and Effox 20 mg.
Dyderski
S
S
Katedry i Zakładu Farmacji Klinicznej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu.
Szkutnik
D
D
Drobnik
L
L
Szymańska-Shawkat
E
E
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000493:pharmacokinetics*
D014665:Vasodilator Agents; D011433:Propranolol; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate