[Serum pro-oxidant and antioxidant factors and risk of Parkinson's disease: population study].
BACKGROUND
Several studies suggested a role of 'oxidative stress' (increased production of prooxidants, antioxidants deficiencies or both) in the pathogenesis of Parkinson's disease. In this study we have measured the serum levels of a number of prooxidant and antioxidant substances to evaluate their possible relation with the risk for Parkinson's disease.


METHODS
We assessed the serum levels of iron, ferritin, ansferrin, ceruloplasmine, vitamin A, alpha-carotene, beta-carotene, and alpha-tocopherol, in 28 patients with Parkinson's disease and 85 matched controls. All of them were recruited from a population study.


RESULTS
None of the values studied differed significantly between the two study groups, and none of them were correlated with age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale or the Hoehn and Yahr staging in the Parkinson's disease group.


CONCLUSIONS
These results confirm the previous findings of classic case-control studies, suggesting the absence of relationship of the studied values with the risk for Parkinson's disease.
Molina-Arjona
J A
JA
Servicio de Neurología, Hospital 12 de Octubre, Madrid.
de Bustos
F
F
Benito-León
J
J
Jiménez-Jiménez
F J
FJ
Rodríguez
J
J
Trincado
R
R
Porta-Etessan
J
J
Vega
S
S
Bermejo
F
F
D017668:Age of Onset; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D002338:Carotenoids / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D016877:Oxidants / Q000097:blood*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000097:blood / Q000453:epidemiology*; D015995:Prevalence; D012306:Risk; D012720:Severity of Illness Index; D013030:Spain / Q000453:epidemiology; D014168:Transferrin / Q000032:analysis; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
D000975:Antioxidants; D016877:Oxidants; D014168:Transferrin; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; C041635:alpha-carotene; D005293:Ferritins; D007501:Iron; D002570:Ceruloplasmin