title: The effect of APOE on dementia is not through atherosclerosis: the Rotterdam Study.
abstract: The APOE genotype is involved in atherosclerosis, and atherosclerosis increases the risk of dementia, in particular among carriers of the APOE-epsilon4 allele. We studied, in a population-based setting (244 dementia cases; 1,002 nondemented controls), whether APOE is associated with dementia through atherosclerosis. As neither adjusting nor stratification for atherosclerosis altered the association of APOE with dementia, our study suggests that atherosclerosis is not an intermediate factor.
authors.affiliation: Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Slooter
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: A
authors.initials: A
authors.lastname: Ott
authors.forename: M L
authors.initials: ML
authors.lastname: Bots
authors.forename: J C
authors.initials: JC
authors.lastname: Witteman
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
mesh_terms: D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics* / Q000523:psychology*; D003704:Dementia / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D012016:Reference Values
chemical_list: D001057:Apolipoproteins E