title: Alpha(1)-acid glycoprotein, age, and sex in mood disorders.
abstract: Serum alpha(1)-acid glycoprotein (AAG) reportedly can increase with age in the normal population, especially among women. In 33 patients with unipolar major depression or bipolar disorder, serum AAG was measured by age. The authors noted a positive association with age, particularly in depressed female patients (n=18; r(s)=0.61; P<0.01). The authors discuss implications for drug pharmacokinetics. Investigation of AAG in mood disorders needs to take age and sex into consideration.
authors.affiliation: New York Presbytarian Hospital, Westchester Division, White Plains, NY 10605, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Young
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: B S
authors.initials: BS
authors.lastname: Meyers
authors.forename: T
authors.initials: T
authors.lastname: Kakuma
authors.forename: G S
authors.initials: GS
authors.lastname: Alexopoulos
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000493:pharmacokinetics; D012737:Sex Factors
chemical_list: D009961:Orosomucoid; D011619:Psychotropic Drugs