[Isothiorbamin possesses stress-protective action].
It was shown on a model of long-term stress induced by chronic electrostimulation of the ventromedial hypothalamus of rabbits that administration of isothiorbamin in the active periods of the experiment prevents hyperactivation of lipid peroxidation in the blood and myocardium by maintaining the activity of antioxidant enzymes. Isothiorbamin also causes an antiatherogenic effect on the blood lipid spectrum, raises the efficacy of the work of the heart and decreases the stressogenic ischemic disorders of the myocardium.
Nikolaev
V I
VI
St. Petersburg State Medical Academy, Russia.
Denisenko
N P
NP
Zharkov
A N
AN
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011743:Pyrimidines / Q000627:therapeutic use*; D011817:Rabbits; D013315:Stress, Psychological / Q000378:metabolism / Q000517:prevention & control*; D013858:Thiobarbiturates / Q000627:therapeutic use*; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
D011743:Pyrimidines; D013858:Thiobarbiturates; C050596:isothiobarbamin