Inspiratory flow rates through a novel dry powder inhaler (Clickhaler) in pediatric patients with asthma.
Inspiratory flow profiles through a novel dry powder inhaler (DPI) (Clickhaler; Innovata Biomed Ltd, St. Albans, UK) were recorded in 17 pediatric patients (aged 7-16 years) with stable mild to moderate asthma. Most patients (n = 14) could generate high peak inspiratory flows (PIFs) (> 60 L/min) and high flows early in the flow profile. These flows have been shown to be adequate to deaggregate and deliver micronized drug with this delivery system.
Nantel
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Barnett Medical Aerosol Research Laboratory, St. Joseph's Hospital, McMaster University, Hamilton, Ontario, Canada.
Newhouse
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D000280:Administration, Inhalation; D000293:Adolescent; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D009330:Nebulizers and Vaporizers; D011208:Powders; D012815:Signal Processing, Computer-Assisted
D000336:Aerosols; D011208:Powders