[Regulation of gene expression and vitamin].
Action of 1,25-dihydroxyvitamin D, the most active metabolite of vitamin D, is exerted by the nuclear vitamin D receptor (VDR) mediated gene expression. Toward the expression of vitamin D function, several steps including 1,25-dihydroxyvitamin D production, tissue specific expression of VDR and transcription of target gene by VDR are involved. One of the important progress in vitamin D metabolism is the cloning of 25-hydroxyvitamin D-24-hydroxylase gene and 1 alpha-hydroxylase gene. Structural organization of the human VDR chromosomal gene and its promoter was also important to understand the amount of VDR expressed in tissues. A part of mechanism of tissue specific expression of VDR have recently been reported. Furthermore, VDR recruit several coactivators to achieve vitamin D-induced transactivation. Selective coactivator interaction with VDR may specify the array of biological actions of vitamin D.
Takeda
E
E
Department of Clinical Nutrition, School of Medicine, University of Tokushima.
Yamamoto
H
H
Miyamoto
K
K
D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000502:physiology; D014158:Transcription, Genetic; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism* / Q000502:physiology
D018167:Receptors, Calcitriol; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D