Polydiaxonon prevents adhesions in the rabbit model: a pilot report.
OBJECTIVE
Restrictive strabismus is a common and difficult problem confronted by strabismologists. Several materials have been used to minimize the formation of adhesions after strabismus surgery with varying degrees of success. Polydiaxonon (PDS, Ethicon) is an absorbable, nontoxic, nonporous material. We used it as 25 and 50 microm thick sleeves to study its effectiveness in the prevention of adhesions.


METHODS
Eight eyes of four adult New Zealand White rabbits were used. To simulate the adhesions, a raw scleral bed was created under the superior rectus insertion in study animals and the muscle capsule facing the sclera was opened. Four study eyes had PDS sleeves inserted around the superior rectus; the other four served as controls. After 4 months the animals were killed. The surgical sites were inspected for adhesions. Light microscopy was also performed.


RESULTS
Virtually no adhesion formation was noted in the study eyes. In the control group, however, dense adhesions were seen. Light microscopy confirmed these results. No significant amount of foreign material was found. There was no toxicity resulting from PDS.


CONCLUSIONS
This demonstrated nearly complete prevention of adhesions in the rabbit model. PDS sleeves appear to have potential in surgery for restrictive strabismus.
Sondhi
N
N
Department of Ophthalmology, Indiana University, Indianapolis, USA.
Koseoglu
S T
ST
Bonnin
J M
JM
Fahad
B
B
D020341:Absorbable Implants; D000818:Animals; D004146:Dioxanes / Q000627:therapeutic use*; D009801:Oculomotor Muscles / Q000473:pathology / Q000601:surgery*; D010865:Pilot Projects; D011108:Polymers / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D015422:Scleral Diseases / Q000517:prevention & control*; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
D004146:Dioxanes; D011108:Polymers; C079733:poly-4-dioxan-2-one