Immunocytochemical localization of cPLA2 in rat and monkey spinal cord.
Rat spinal cord contains a high level of calcium-dependent cytosolic phospholipase A2 (PLA2) activity. A dense immunoreactivity is present in motor neurons from cervical, thoracic, lumbar, and sacral regions of rat spinal cord. Under normal conditions, this enzyme liberates arachidonic acid, a polyunsaturated fatty acid that is a second messenger itself, and a precursor for eicosanoids. However, under pathological conditions during spinal cord injury, intracellular calcium increases so the cytosolic PLA2 may also be involved in the release and accumulation of arachidonic acid, eicosanoids, and lipid peroxides.
Ong
W Y
WY
Department of Anatomy, National University of Singapore, Singapore.
Horrocks
L A
LA
Farooqui
A A
AA
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron; D010741:Phospholipases A / Q000032:analysis* / Q000378:metabolism; D054467:Phospholipases A2; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000201:enzymology* / Q000648:ultrastructure; D013119:Spinal Cord Injuries / Q000378:metabolism*
D016718:Arachidonic Acid; D010741:Phospholipases A; D054467:Phospholipases A2