title: Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease.
abstract: This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.
authors.affiliation: Melbourne Neuromuscular Research Center, St Vincent's Hospital, Fitzroy, Victoria, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Ojaimi
authors.forename: C L
authors.initials: CL
authors.lastname: Masters
authors.forename: C
authors.initials: C
authors.lastname: McLean
authors.forename: K
authors.initials: K
authors.lastname: Opeskin
authors.forename: P
authors.initials: P
authors.lastname: McKelvie
authors.forename: E
authors.initials: E
authors.lastname: Byrne
mesh_terms: D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
chemical_list: D003576:Electron Transport Complex IV