Solubilization of fluasterone.
Solubilization of nonpolar drugs constitutes one of the most important tasks in parenteral formulations design. This study investigates and assesses the solubility enhancement of Fluasterone by various techniques including cosolvency, micellization, and complexation. Of the solubilizing agents used, the modified beta-cyclodextrins were found to be the most effective. The solubility of Fluasterone is 1.55 x 10(-4) mM, 3.13 mM, and 4.04 mM in water, 20% sulfobutyl ether-beta-cyclodextrin (SBEbetaCD), and 20% hydroxypropyl-beta-cyclodextrin (HPbetaCD), respectively.
Zhao
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Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA.
Li
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Yalkowsky
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SH
D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000737:chemistry; D008823:Micelles; D012995:Solubility; D012997:Solvents; D013501:Surface-Active Agents
D003505:Cyclodextrins; D008823:Micelles; D012997:Solvents; D013501:Surface-Active Agents; D003687:Dehydroepiandrosterone; C106219:5-androstene-16-fluoro-17-one