Glutamate transport and renal function.
Brush border gamma-glutamyltransferase-glutaminase activity and the high-affinity glutamate transporter EAAC1 function as a unit in generating and transporting extracellular glutamate into proximal tubules as a signal that modulates intracellular glutamine/glutamate metabolism, paracellular permeability, and urinary acidification. The reported presence of a second glutamate transporter, GLT1, on the antiluminal tubule surface points to specific functional roles for each subtype in physiological and pathophysiological processes.
Welbourne
T C
TC
Department of Molecular Physiology, Louisiana State University Medical Center, Shreveport, Louisiana 71130, USA. twelbo@lsunc.edu
Matthews
J C
JC
D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D027322:Amino Acid Transport System X-AG; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D050491:Glutamate Plasma Membrane Transport Proteins; D018698:Glutamic Acid / Q000378:metabolism; D007668:Kidney / Q000502:physiology*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D027981:Symporters; D005723:gamma-Glutamyltransferase / Q000502:physiology
D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D050491:Glutamate Plasma Membrane Transport Proteins; D027981:Symporters; D018698:Glutamic Acid; D005723:gamma-Glutamyltransferase