title: [Validation of the three-dimensional method of sestamibi gated-SPECT in the calculation of the left ventricular ejection fraction in patients with ischemic heart disease. Comparison with contrast ventriculography].
abstract: OBJECTIVE
  Tomography with acquisition synchronized with electrocardiography, gated-tomography, allows the assessment of left ventricular contractile function. The accuracy of a new method of gated-tomography, based on the three dimensional representation of the left ventricle to calculate the ejection fraction was validated by means of comparison with contrast ventriculography.
  
  
  METHODS
  We studied 85 patients with ischemic cardiopathy, and ejection fraction was calculated by contrast ventriculography and sestamibi-gated-tomography, at rest and throughout 10 micrograms/kg/min of dobutamine. Furthermore, we assessed the extent of perfusion defect, as well as the number of segments with activity below 50% of the total 13 segments in which the tomographic slices were divided.
  
  
  RESULTS
  Gated-tomography was significantly correlated to contrast ventriculography in the calculation of ejection fraction, both with acquisition at rest (r = 0.80) and throughout Dobutamine (r = 0.82). The average underestimation of gated-tomography calculation of ejection fraction was significantly greater for the rest study (-0.12 [IC 95% 0.04, -0.30]) than the dobutamine study (-0.07 [IC 95% 0.09, -0.24]). Patients with greater perfusion defects (4 o more segments) had no differences in underestimation of ejection fraction (-0.13 [IC 95% 0.03, -0.30] versus -0.11 [IC 95% 0.07, -0.29]).
  
  
  CONCLUSIONS
  The three-dimensional method of gated-tomography accurately assesses the ejection fraction. The underestimation determined by this method was lower in the study done with viable doses of dobutamine. The extent of perfusion defect had no deleterious effect on gated-tomography in the calculation of ejection fraction.
authors.affiliation: Departamento de Cardiología Intervencionista, Hospital do Meixoeiro, Vigo, Pontevedra. romeo@arrakis.es
authors.forename: R
authors.initials: R
authors.lastname: Ruiz-Salmerón
authors.forename: E
authors.initials: E
authors.lastname: Ponce de León
authors.forename: A
authors.initials: A
authors.lastname: López
authors.forename: R
authors.initials: R
authors.lastname: Guitián
authors.forename: D
authors.initials: D
authors.lastname: Romeo
authors.forename: V
authors.initials: V
authors.lastname: del Campo
authors.forename: R
authors.initials: R
authors.lastname: Mantilla
authors.forename: J
authors.initials: J
authors.lastname: Pasalodos
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis / Q000503:physiopathology*; D003627:Data Interpretation, Statistical; D005069:Evaluation Studies as Topic; D005260:Female; D015637:Gated Blood-Pool Imaging; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D013318:Stroke Volume; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi