Expression of NPY Y1 and CGRP1 receptors in human nasal mucosa: implications in allergic rhinitis.
Numerous nerve fibers containing neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) have been found in the human nasal mucosa by means of immunocytochemistry. We detected NPY Y1 and CGRP1 receptors at the same location using reverse transcriptase-polymerase chain reaction. The possibility of local release in connection with specific target receptors suggests a role for endogenous NPY and CGRP in the regulation of vascular tone, glandular secretion, and epithelial functions.
Uddman
R
R
Department of Otorhinolaryngology, Malmö General Hospital, Sweden.
Cantera
L
L
Cardell
L O
LO
Edvinnsson
L
L
D000328:Adult; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000166:cytology*; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000235:genetics*; D017476:Receptors, Neuropeptide Y / Q000235:genetics*; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics*
D018015:Receptors, Calcitonin Gene-Related Peptide; D017476:Receptors, Neuropeptide Y