title: Modulation of the inflammatory reaction and neutrophil defense of the bovine lactating mammary gland by growth hormone.
abstract: This review is focused on the possible interactions of prolactin and somatotrope hormone in the modulation of inflammation of the mammary gland. Several different models are examined: Escherichia coli, Streptococcus uberis, and endotoxin mastitis. Subsequently, the release of growth hormone and insulin-like growth factor during fever and mastitis, the immunophysiological effects of GH on E. coli mastitis, S. uberis and endotoxin mastitis, the galactopoietic action of rBST on healthy and mastitis cows as well as the immunologic effects of GH on leukocytes in healthy and diseased cows are discussed. It can be concluded that the underlying regulation of the neuro-endocrine network is fundamental in the normal function of the immune system.
authors.affiliation: Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium. christian.burvenich@rug.ac.be
authors.forename: C
authors.initials: C
authors.lastname: Burvenich
authors.forename: M J
authors.initials: MJ
authors.lastname: Paape
authors.forename: D
authors.initials: D
authors.lastname: Hoeben
authors.forename: H
authors.initials: H
authors.lastname: Dosogne
authors.forename: A M
authors.initials: AM
authors.lastname: Massart-Leën
authors.forename: J
authors.initials: J
authors.lastname: Blum
mesh_terms: D000818:Animals; D002417:Cattle; D004731:Endotoxins / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D005260:Female; D013006:Growth Hormone / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D007334:Insulin-Like Growth Factor I / Q000276:immunology / Q000378:metabolism; D007774:Lactation; D008321:Mammary Glands, Animal / Q000276:immunology* / Q000503:physiopathology; D008414:Mastitis, Bovine / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D008892:Milk / Q000737:chemistry / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology*; D011388:Prolactin / Q000276:immunology*; D013290:Streptococcal Infections / Q000276:immunology / Q000628:therapy / Q000662:veterinary*
chemical_list: D004731:Endotoxins; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone