[Diagnostic and prognostic significance of blood-serum ceruloplasmin, acetylcholinesterase and total proteolytic activity in patients with multiple myeloma].
The study included 82 patients with multiple myeloma (MM) to evaluate the diagnostic and prognostic significance of correlation between of levels of ceruloplasmin (CP), acetylcholinesterase (ACE) and total proteolytic activity (TPA) in blood serum and immunochemical pattern, tumor mass and response to chemotherapy. It was shown that CP, ACE and TPA determination may be used as additional markers to confirm therapeutic benefits, to timely detect relapse and to verify resistance to chemotherapy. It was also demonstrated that resultant decrease in CP and TPA and increase in ACE levels are reliable indicators of changes developing in MM course and remission fulfillment. High values for CP and low ones for ACE point to pathological activity. Both diagnostic and prognostic significance of the indices has been shown. The highest levels of CP and TPA in blood serum were identified in cases of A-myeloma and myeloma of Bence Jones while ACE concentrations in those patients were lower than in G-myeloma which correlated with median survival. Application of said assays might improve diagnosis, management and prognosis of MM.
Bessmel'tsev
S S
SS
Russian Research Institute of Hematology and Transfusiology, St. Petersburg.
Rybakova
L P
LP
Gritskevich
N L
NL
Golota
G Z
GZ
Blinov
M N
MN
Abdulkadyrov
K M
KM
D000110:Acetylcholinesterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D001536:Bence Jones Protein / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000175:diagnosis* / Q000201:enzymology; D009363:Neoplasm Proteins / Q000097:blood*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D001798:Blood Proteins; D009363:Neoplasm Proteins; D001536:Bence Jones Protein; D002570:Ceruloplasmin; D000110:Acetylcholinesterase