[Substituted thiazolidinediones and thioxothiazolidinones: synthesis and structure].
Synthesis and physico-chemical properties of 3-(4-bromobenzyl)-, 3-(4-chlorobenzyl)-5-arylidene-thiazolidine-2,4-diones and 3-(4-chlorobenzyl)-4-thioxo-5-arylidene-thiazolidin-2- ones are described. Twelve new products were synthesized by the aldolisation-crotonisation reaction from aromatic aldehydes and N-alkylated thiazolidinediones or thioxothiazolidinones. Seven compounds were preliminary tested for their bacteriostatic activity.
Albuquerque
J F
JF
Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Brasil.
Andrade
A M
AM
Barros
A L
AL
Nascimento
M R
MR
Ximenes
E A
EA
Galdino
S L
SL
Pitta
I R
IR
Perrissin
M
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013844:Thiazoles