Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosa.
It is well recognized that lipid in the intestine is a potent inhibitor of gastric secretomotor function. Progress has been made in the identification of the "sensor" for lipid in the intestinal wall. Long-chain free fatty acids are the stimulus both for release of CCK and for the production of functional effects. Long-chain triglyceride requires chylomicron formation for absorption, and there is strong evidence that the postabsorptive products of long-chain triglyceride absorption, including chylomicrons and apolipoproteins, are involved in sensory transduction in the intestinal wall.
Raybould
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CURE: Digestive Diseases Research Center, West Los Angeles Veterans Affairs Medical Center, Los Angeles, California 90095, USA. hrayboul@ucla.edu
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001054:Apolipoproteins A / Q000378:metabolism; D002628:Chemoreceptor Cells / Q000378:metabolism*; D002766:Cholecystokinin / Q000378:metabolism; D002914:Chylomicrons / Q000378:metabolism; D004435:Eating; D005746:Gastric Emptying; D007413:Intestinal Mucosa / Q000294:innervation* / Q000378:metabolism*; D050356:Lipid Metabolism; D015398:Signal Transduction; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism
D000975:Antioxidants; D001054:Apolipoproteins A; D002914:Chylomicrons; D014280:Triglycerides; C022205:apolipoprotein A-IV; D002766:Cholecystokinin