Antibacterial activity of multiple antigen peptides homologous to a loop region in human lactoferrin.
An 11-residue peptide (FQWQRNMRKVR) homologous to just over half the loop region of human lactoferricin is thought to be responsible for antimicrobial properties of human lactoferricin. Multiple antigen peptides (MAP) of the 11-residue peptide exerted significant antibacterial effects against a broad spectrum of bacteria including MRSA. More than eight branching was favourable for increasing its antibacterial activity. Our report shows a novel possibility for MAP to increase the activity of antibiotic peptides other than simply to stimulate antibody production, as reported so far.
Azuma
M
M
Department of Ecological Engineering, Toyohashi University of Technology, Japan.
Kojima
T
T
Yokoyama
I
I
Tajiri
H
H
Yoshikawa
K
K
Saga
S
S
Del Carpio
C A
CA
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000941:Antigens / Q000494:pharmacology*; D001059:Apoproteins / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000494:pharmacology*; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000941:Antigens; D001059:Apoproteins; D010446:Peptide Fragments; D010455:Peptides; D007781:Lactoferrin