Prothrombotic state and elevated levels of plasminogen activator inhibitor-1 in mitral stenosis with and without atrial fibrillation.
Patients with mitral stenosis in sinus rhythm are in a prothrombotic state and have fibrinolytic dysfunction, shown by an increase in levels of the inhibitor of tissue plasminogen activator, D-dimer, and modified antithrombin III. This state may be observed even in patients without dilated left atria (diameter < or =45 mm).
Marín
F
F
Department of Cardiology, General Hospital of Elche, Alicante, Spain.
Roldán
V
V
Monmeneu
J V
JV
Bodí
V
V
Fernández
C
C
de Burgos
F G
FG
Marco
P
P
Sogorb
F
F
D001281:Atrial Fibrillation / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D004452:Echocardiography; D005260:Female; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013917:Thrombin / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D005337:Fibrin; D013917:Thrombin; D010959:Tissue Plasminogen Activator