Candida isolates from neonates: frequency of misidentification and reduced fluconazole susceptibility.
Systemic candidiasis affects 1.6 to 4.5% of very low birth weight (</= 1,500 g) infants. A specimen archive of Candida strains from intensive care nurseries was created; it currently houses 98 isolates from 17 institutions. Eight isolates (8.2%) were misidentified at the referring institution. The MICs of fluconazole for seven isolates (7.1%, all non-C. albicans species, one misidentified initially) were >8 microg/ml.
Rowen
J L
JL
Departments of Pediatrics, University of Texas Medical Branch, Galveston, Texas 77555, USA. jrowen@utmb.edu
Tate
J M
JM
Nordoff
N
N
Passarell
L
L
McGinnis
M R
MR
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification*; D002176:Candida albicans / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003951:Diagnostic Errors; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D013045:Species Specificity
D000935:Antifungal Agents; D015725:Fluconazole