title: Molecular characterization of the ligand-receptor interaction of neuropeptide Y.
abstract: Neuropeptide Y (NPY) consists of 36 amino acids and is one of the most abundant peptides in the peripheral and central nervous system. Several subtypes of NPY receptors have been described (Y1- y6) using segments and analogues of NPY. The Y1-, Y2- and the Y5-receptor, which have been cloned, belong to the G-protein coupled hormone receptor family and will be specially addressed, because they are the endogenous binding sites of neuropeptide Y in human. In contrast, Y4-receptors recognize endogenous PP, Y3 receptors are discussed controversially and the y6-receptor is truncated in human. In this review, we summarize the data of neuropeptide Y with respect to ligand binding, selectivity, receptor structures and ligand-receptor complexes by using ligand analogues, site directed mutagenesis and photoaffinity labeling.
authors.affiliation: Swiss Federal Institute of Technology Zürich, Department of Pharmacy, Winterthurer Str. 190, Zürich, CH 8057, Zürich.
authors.forename: N
authors.initials: N
authors.lastname: Ingenhoven
authors.forename: A G
authors.initials: AG
authors.lastname: Beck-Sickinger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001067:Appetite Depressants / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000737:chemistry / Q000494:pharmacology*; D017476:Receptors, Neuropeptide Y / Q000737:chemistry / Q000187:drug effects*
chemical_list: D001067:Appetite Depressants; D008024:Ligands; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y