title: [10 years' experience of using cultured human skin cells for the treatment of thermal burns].
abstract: The authors have developed a unique method of treating extensive burns by transplantation of the cultivated cells on the affected area. The main elements of the transplant are not keratinocytes but fibroblasts, and this is a principal difference with other methods. The transplanted fibroblasts actively synthesize DNA, collagen, fibronectin, glycosaminoglycanes which comprise the extracellular matrix formed by cells. The method is simple, cost-effective, provides high percentage of fibroblast transplant survival, essential acceleration of the burn area epithelialization as compared to other methods. This method was applied in the treatment of 517 patients in various hospitals of the country.
authors.affiliation: A. V. Vishnevsky Institute of Surgery, Moscow.
authors.forename: V P
authors.initials: VP
authors.lastname: Tumanov
authors.forename: A A
authors.initials: AA
authors.lastname: Alekseev
authors.forename: L I
authors.initials: LI
authors.lastname: Budkevich
mesh_terms: D000328:Adult; D002056:Burns / Q000601:surgery*; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D012867:Skin / Q000166:cytology*; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome