title: Transmyocardial laser revascularization. Early clinical experience.
abstract: OBJECTIVE
  To analyze the initial clinical experience of transmyocardial laser revascularization (TMLR) in patients with severe diffuse coronary artery disease.
  
  
  METHODS
  Between February, 1998 and February, 1999, 20 patients were submitted to TMLR at the Heart Institute (InCor), University of São Paulo Medical School, Brazil, isolated or in association with conventional coronary artery bypass graft (CABG). All patients had severe diffuse coronary artery disease, with angina functional class III/IV (Canadian Cardiovascular Society score) unresponsive to medical therapy. Fourteen patients were submitted to TMLR as the sole therapy, whereas 6 underwent concomitant CABG. Fifty per cent of the patients had either been previously submitted to a CABG or to a percutaneous transluminal coronary angioplasty (PTCA). Mean age was 60 years, ranging from 45 to 74 years.
  
  
  RESULTS
  All patients had three-vessel disease, with normal or mildly impaired left ventricular global function. Follow-up ranged from 1 to 13 months (mean 6.6 months), with no postoperative short or long term mortality. There was significant symptom improvement after the procedure, with 85% of the patients free of angina, and the remaining 15% of the patients showing improvement in functional class, as well as in exercise tolerance.
  
  
  CONCLUSIONS
  This novel technique can be considered a low risk alternative for a highly selected group of patients not suitable for conventional revascularization procedures.
authors.affiliation: Heart Institute-University of São Paulo Medical School, Brazil.
authors.forename: S A
authors.initials: SA
authors.lastname: de Oliveira
authors.forename: L A
authors.initials: LA
authors.lastname: Dallan
authors.forename: L A
authors.initials: LA
authors.lastname: Lisboa
authors.forename: M C
authors.initials: MC
authors.lastname: Chavantes
authors.forename: L A
authors.initials: LA
authors.lastname: Cesar
authors.forename: M J
authors.initials: MJ
authors.lastname: Pardi
authors.forename: A D
authors.initials: AD
authors.lastname: Jatene
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000601:surgery*; D003327:Coronary Disease / Q000601:surgery*; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000379:methods*