title: BMP stimulation of bone response adjacent to titanium implants in vivo.
abstract: The objective of this study was to evaluate the effect of bone morphogenetic protein (BMP) on the bond strength of titanium (Ti) implants at the bone-implant interface. Thirty-six Brånemark screw implants (3.75 mm diameter by 15 mm long) were implanted for 3 and 12 weeks. At 3 weeks after implantation, the mean reverse torque value for implants stimulated with BMP delivered using an atelopeptide type-I collagen carrier (74.2 +/- 5.2 N cm) was observed to be statistically greater (P < 0.000016) than the mean reverse torque value for control Ti implants (32.8 +/- 1.1 N cm). Similarly, at 12 weeks after implantation, the mean reverse torque value for implants stimulated with BMP (89.2 +/- 2.7 N cm) was statistically greater (P < 0.0042) than the mean reverse torque value for control Ti implants (75.8 +/- 2.4 N cm). In addition, histomorphometric evaluations indicated more bone contact with the BMP stimulated implant surfaces compared to the controls after 3 weeks implantation. It was concluded from this study that the use of BMP-atelopeptide type-I collagen mixture is an effective means of obtaining greater bond strength at the bone implant interface within a shorter time period than Ti implants without BMP.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Bessho
authors.forename: D L
authors.initials: DL
authors.lastname: Carnes
authors.forename: R
authors.initials: R
authors.lastname: Cavin
authors.forename: H Y
authors.initials: HY
authors.lastname: Chen
authors.forename: J L
authors.initials: JL
authors.lastname: Ong
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D004337:Drug Carriers; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D014025:Titanium / Q000737:chemistry; D019415:Torque
chemical_list: D019485:Bone Morphogenetic Proteins; D015921:Dental Implants; D004337:Drug Carriers; C059821:atelocollagen; D003094:Collagen; D014025:Titanium