[Once-daily dosage of aminoglycosides--a therapeutic simplification and an economical benefit].
Conventionally, aminoglycosides have been administered in two or three daily doses. Numerous in-vitro and animal experiments and several clinical trials favour a once-daily dosage regimen of aminoglycosides, which provides a more rapid concentration-dependent bacterial killing and is probably less toxic than two or three dosage regimens. In this article the pharmacological and microbiological background for once-daily aminoglycoside administration is reviewed, and some controlled trials are discussed. Recommendations for clinical practice are given.
Berild
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Medisinsk klinikk Aker sykehus, Oslo.
Sjursen
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Digranes
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D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000191:economics; D001424:Bacterial Infections / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics; D017408:Guidelines as Topic; D006801:Humans; D015201:Meta-Analysis as Topic; D009428:Netilmicin / Q000008:administration & dosage / Q000009:adverse effects / Q000191:economics; D016032:Randomized Controlled Trials as Topic
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin