title: Identification of aminoethylcysteine ketimine decarboxylated dimer in human plasma.
abstract: Aminoethylcysteine ketimine decarboxylated dimer (AECK-DD) is a natural sulfur-containing tricyclic compound detected, until now, in human urine and bovine cerebellum. Recently, the antioxidant properties of this compound, and particularly its protective effect on the in vitro oxidation of low-density lipoproteins, have been demonstrated. In this paper, the identification of AECK-DD in human plasma by means of gas chromatography, high-performance liquid chromatography and gas chromatography-mass spectrometry, performed after a simple and fast purification procedure, is reported.
authors.affiliation: Dipartimento di Scienze Biochimiche A. Rossi Fanelli, Università di Roma La Sapienza, Rome, Italy. mmatares@axcasp.caspur.it
authors.forename: R M
authors.initials: RM
authors.lastname: Matarese
authors.forename: A
authors.initials: A
authors.lastname: Macone
authors.forename: R
authors.initials: R
authors.lastname: Antonini
authors.forename: A
authors.initials: A
authors.lastname: Maggio
authors.forename: A
authors.initials: A
authors.lastname: Antonucci
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood; D009025:Morpholines / Q000097:blood* / Q000302:isolation & purification
chemical_list: C086349:5,9a-dihydro-5-oxopyrrolo(2,1-c-3,4-b')dithiomorpholine; D008074:Lipoproteins; D009025:Morpholines