Radial microbrain form of micrencephaly: possible association with carbamazepine.
A premature infant exposed to carbamazepine in utero had a markedly undersized brain on cranial ultrasonogram. Postmortem examination of the brain revealed no evidence of hypoxic-ischemic injury, hemorrhage, infarction, congenital infection, or calcification. The normal cortical gyral pattern, normal residual germinal matrix, and normal cortical lamination suggested the diagnosis of a radial microbrain form of micrencephaly.
Hashimoto
L N
LN
Department of Pediatrics, Eastern Virginia Medical School, Norfolk, USA.
Bass
W T
WT
Green
G A
GA
Werner
A L
AL
Reagan
T J
TJ
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008831:Microcephaly / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D012640:Seizures / Q000188:drug therapy; D014463:Ultrasonography
D000927:Anticonvulsants; D002220:Carbamazepine