Hamycin treatment of candidiasis in normal and diabetic rats.
Hamycin, a heptaene antifungal antibiotic was compared with amphotericin B in the treatment of established systemic infection with Candida albicans in normal and diabetic rats. In normal rats, orally administered hamycin at 10 mg kg(-1) per day for 7 days reduced Candida colony counts in the kidneys and livers as well as amphotericin B did and was nearly as effective as amphotericin B in a 21-day treatment trial. There was no further reduction in Candida colony counts when normal rats were treated with hamycin at 25 mg kg(-1) twice a day for 7 days. In streptozotocin induced diabetic rats, hamycin at 20 mg kg(-1) per day for either 7 or 21 days compared favourably with amphotericin B in efficacy. Results of the present study suggest that oral hamycin may be useful in the treatment of established disseminated candidiasis in normal as well as diabetic hosts.
Dhuley
J N
JN
Department of Pharmacology and Toxicology, Research and Development Division, Hindustan Antibiotics Ltd., Pimpri, Pune, India.
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002176:Candida albicans / Q000254:growth & development; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D015169:Colony Count, Microbial; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D011090:Polyenes / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats
D000935:Antifungal Agents; D011090:Polyenes; C100114:hamycin; D000666:Amphotericin B