Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats.
Physostigmine is known to antagonize ketamine anesthesia. In this study, effects of physostigmine (0.1 mg kg(-1) i.p.) on ketamine (100 mg kg(-1) i.p.)-induced anesthesia time and noradrenaline release from the medial prefrontal cortex in rats were examined. Ketamine produced anesthesia for 27+/-1 min and increased noradrenaline release to 405% of the basal. Physostigmine significantly reduced anesthesia time to 23+/-1 min (p<0.05), and noradrenaline to 248% (p<0.05). Therefore, noradrenaline release may play an important role in ketamine anesthesia.
Kubota
T
T
Department of Anesthesiology, University of Hirosaki School of Medicine, 5 Zaifu-cho, Hirosaki, Japan.
Hirota
K
K
Anzawa
N
N
Yoshida
H
H
Kushikata
T
T
Matsuki
A
A
D000758:Anesthesia; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010830:Physostigmine / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000778:Anesthetics, Dissociative; D002800:Cholinesterase Inhibitors; D007649:Ketamine; D010830:Physostigmine; D009638:Norepinephrine