[Treatment of Barrett esophagus with argon plasma coagulation with acid suppression--a prospective study].
26 patients with a Barrett's esophagus of at least 2 cm length (medium 4.9 cm) were treated with a combination of repeated argon-plasma-coagulation (APC) and a long-term acid suppression using proton pump inhibitors controlled by a 2 h pH monitoring. Eleven out of 26 patients (42%) showed endoscopically and histologically a complete eradication of the metaplastic cylindric epithelium (intention--to treat analysis). Nine patients (35%) had an endoscopic complete remission but remnants of the cylindric epithelium were found at the histologic examination. On an average one APC-session was necessary for 1 cm of initial length of the Barrett's esophagus. No serious complications were seen. It remains unclear if this therapy can reduce the long-term risks for adenocarcinoma of the esophagus in patients with Barrett's esophagus.
Martin
W R
WR
Medizinischen Klinik C, Klinikum der Stadt Ludwigshafen am Rhein gGmbH.
Jakobs
R
R
Spiethoff
A
A
Maass
S
S
Riemann
J F
JF
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001471:Barrett Esophagus / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology / Q000601:surgery; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D064747:Lansoprazole; D017075:Laser Coagulation; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D054328:Proton Pump Inhibitors; D016896:Treatment Outcome
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D009853:Omeprazole