title: Granulocytic sarcoma of the thymus in a nonleukaemic patient.
abstract: We report a case of granulocytic sarcoma arising from the thymus in a 17-year-old nonleukaemic patient. The patient presented with an anterior mediastinal tumour and underwent surgical resection. Histological examination showed a diffuse infiltrate of immature round cells in the thymus. Tumour cells were diffusely peroxidase positive, but naphthol AS-D chloroacetate esterase negative. Immunohistochemical staining revealed expression of CD34 and terminal deoxynucleotidyl transferase (TdT), but not of CD13 and CD33. Ultrastructurally, electron-dense or medium-density granules were present in the cytoplasm. Four months after successful autogenic bone marrow transplantation, pleural and pericardial fluid contained tumour cells with azurophilic granules, which expressed CD13 and CD33, but not CD34 and TdT. The patient died of the disease 18 months after clinical manifestation, but still without developing leukaemia. The granulocytic sarcoma in the present case may have originated from myeloid precursors in the thymus and remained within the extramedullary site despite the differentiation into a more committed myeloid lineage at the relapse.
authors.affiliation: Department of Pathology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8867, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hishima
authors.forename: M
authors.initials: M
authors.lastname: Fukayama
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Shiozawa
authors.forename: N
authors.initials: N
authors.lastname: Funata
authors.forename: H
authors.initials: H
authors.lastname: Sakamaki
authors.forename: M
authors.initials: M
authors.lastname: Koike
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D013953:Thymus Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure