Correlation between cerebral oxygen saturation measured by near-infrared spectroscopy and jugular oxygen saturation in patients with severe closed head injury.
Near-infrared spectroscopy has been used to monitor cerebral oxygen saturation during cerebral circulatory arrest and carotid clamping. However, its utility has not been demonstrated in more complex situations, such as in patients with head injuries. The authors tested this method during conditions that may alter the arteriovenous partition of cerebral blood in different ways.


METHODS
The authors compared changes in measured cerebral oxygen saturation and other hemodynamic parameters, including jugular venous oxygen saturation, in nine patients with severe closed head injury during manipulation of arterial carbon dioxide partial pressure and after mean arterial pressure was altered by vasopressors.


RESULTS
The Bland and Altman representation of cerebral oxygen saturation versus jugular oxygen saturation showed a uniform scatter. Values for changing arterial carbon dioxide partial pressure were: bias = 1.1%, 2 SD = +/-21%, absolute value; and those for alterations in mean arterial pressure: bias = 3.7%, 2 SD = +/-24%, absolute value. However, a Bland and Altman plot of changes in cerebral oxygen saturation versus changes in jugular oxygen saturation had a negative slope (alteration in arterial carbon dioxide partial pressure: bias = 2.4%, 2 SD = +/-17%, absolute value; alteration in mean arterial pressure: bias = -4.9%, 2 SD = +/-31%, absolute value). Regression analysis showed that changes in cerebral oxygen saturation were positively correlated with changes in jugular venous oxygen saturation during the carbon dioxide challenge, whereas correlation was negative during the arterial pressure challenge.


CONCLUSIONS
Cerebral oxygen saturation assessed by near-infrared spectroscopy does not adequately reflect changes in jugular venous oxygen saturation in patients with severe head injury. Changes in arteriovenous partitioning, infrared-spectroscopy contamination by extracerebral signal, algorithm errors, and dissimilar tissue sampling may explain these findings.
Ter Minassian
A
A
Réanimation chirurgicale, Centre Hospitalier Universitaire Larrey, Angers, France. lBeydon.angers@invivo.edu
Poirier
N
N
Pierrot
M
M
Menei
P
P
Granry
J C
JC
Ursino
M
M
Beydon
L
L
D000280:Administration, Inhalation; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology; D016489:Head Injuries, Closed / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007601:Jugular Veins; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
D002245:Carbon Dioxide; D010100:Oxygen