title: [Hepatobiliary and pancreatic disorders as risk factors for fat-soluble vitamin deficiencies].
abstract: The aim of this article is to describe the fat-soluble vitamin status in patients with hepatobiliary and pancreatic diseases, and the contribution of these vitamin deficiency or excess to hepatic injury. A considerable number of patients with advanced liver disease and cholestasis might actually be fat-soluble vitamin deficient, although clinical signs of deficiency are uncommonly seen in patients with vitamin A and E deficiency. Increased bone resorption may be the predominant cause of hepatic osteodystrophy. On the other hand, the possible causes of vitamin K deficiency seen in patients with hepatobiliary disease are the decrease of vitamin K absorption from intestine, the disturbance of vitamin K cycle and the decrease of pool area for vitamin K storage. The intake of vitamin A may be associated with the risk of liver cirrhosis in lifetime teetotalers, although the retinyl palmitate reduces hepatic fibrosis in rats.
authors.affiliation: Dept of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shirahata
mesh_terms: D001361:Avitaminosis / Q000209:etiology*; D001649:Bile Duct Diseases / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D010182:Pancreatic Diseases / Q000150:complications*; D014802:Vitamin A Deficiency / Q000209:etiology; D014808:Vitamin D Deficiency / Q000209:etiology; D014811:Vitamin E Deficiency / Q000209:etiology; D014813:Vitamin K Deficiency / Q000209:etiology