title: Association between umbilical blood gas parameters and neonatal morbidity and death in neonates with pathologic fetal acidemia.
abstract: OBJECTIVE
  Our purpose was to correlate umbilical artery blood gas parameters with neonatal death and indicators of morbidity in neonates with pathologic fetal acidemia (pH <7.0).
  
  
  METHODS
  We reviewed maternal and neonatal charts of 93 neonates with an umbilical artery pH <7.0 who were delivered at 2 university-based centers. The relationships between umbilical artery pH, PO (2), PCO (2), bicarbonate, base deficit, and neonatal variables-death, need for intubation, cardiopulmonary resuscitation, seizures, hypoxic-ischemic encephalopathy, respiratory distress syndrome, intraventricular hemorrhage, meconium, sepsis, and intrauterine growth restriction-were determined with the Student t test, Mann-Whitney U test, and multiple logistic regression analysis. Data are presented as either median with 25th-75th percentiles or mean +/- SD.
  
  
  RESULTS
  The mean gestational age at delivery was 37.9 +/- 3. 6 weeks, and the mean birth weight was 3003 +/- 866 g. There was no relationship between neonatal death, respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, patent ductus arteriosus, meconium, sepsis, and any umbilical artery blood gas parameter. The PO (2) was not related to any of the variables studied. A lower umbilical artery pH was associated with hypoxic-ischemic encephalopathy (6.69 vs 6.93, P =.03), cardiopulmonary resuscitation (6.83 vs 6.93, P =.03), seizure (6.75 vs 6.93, P =.02), intubation (6.83 vs 6.94, P <.001), and intrauterine growth restriction (6.72 vs 6.93, P =.01). Greater mean base deficit was associated with seizure (20.6 vs 15, P =.01), intubation (18.0 vs 13.7, P <.001), cardiopulmonary resuscitation (18.5 vs 15.0, P =.03), intrauterine growth restriction (22.0 vs 14. 0, P =.02), and hypoxic-ischemic encephalopathy (24.0 vs 14.5, P =. 03). Arterial PCO (2) was higher only in infants with hypoxic-ischemic encephalopathy (138 vs 95.5, P =.048), intubation (106.0 vs 90.5, P =.003), and cardiopulmonary resuscitation (106.5 vs 93.0, P =.04). After control for birth weight and gestational age in the multivariate analysis, base deficit and bicarbonate were independently related to death or morbidity.
  
  
  CONCLUSIONS
  Our data suggest that "pathologic" fetal acidemia is indicated by an umbilical artery pH <7.00 with a metabolic component. The metabolic component of fetal acidemia (ie, base deficit and bicarbonate) is the most important variable in subsequent neonatal morbidity. As expected, the umbilical artery PO (2) has no apparent clinical utility. The ability to predict more accurately which newborn infants with fetal acidemia are at risk of having complications may lead to a more efficient implementation of preventive measures.
authors.affiliation: Department of Obstetrics, The University of Texas-Houston Medical School, Houston, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Andres
authors.forename: G
authors.initials: G
authors.lastname: Saade
authors.forename: L C
authors.initials: LC
authors.lastname: Gilstrap
authors.forename: I
authors.initials: I
authors.lastname: Wilkins
authors.forename: A
authors.initials: A
authors.lastname: Witlin
authors.forename: F
authors.initials: F
authors.lastname: Zlatnik
authors.forename: G V
authors.initials: GV
authors.lastname: Hankins
mesh_terms: D000138:Acidosis / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001034:Apgar Score; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood*; D016887:Cardiopulmonary Resuscitation; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005315:Fetal Diseases / Q000097:blood*; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020925:Hypoxia-Ischemia, Brain / Q000097:blood; D007226:Infant Mortality; D007231:Infant, Newborn; D007440:Intubation; D016015:Logistic Models; D010100:Oxygen / Q000097:blood*; D011247:Pregnancy; D012640:Seizures / Q000097:blood
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen