title: Multicystic autoimmune thyroiditis-like disease associated with HIV infection. A case report.
abstract: BACKGROUND
  Human immunodeficiency virus (HIV) infection and resulting acquired immunodeficiency syndrome (AIDS) may involve virtually every organ system, including the endocrine glands. Thyroid dysfunction most commonly reflects advanced disease and generally resembles euthyroid sick syndrome. Rarely do opportunistic infections, hemorrhage, neoplasms and drugs account for alterations in thyroid tissue. Multiple lymphoepithelial cysts of parotid gland and thymus have been identified, but similar findings in thyroid gland have not been reported.
  
  
  METHODS
  A 41-year-old, HIV-seropositive woman, asymptomatic for seven years, developed a squamous cell carcinoma of the cervix with local-regional extension. At the same time, bilateral complex thyroid cysts and high titers of antimicrosomal antibodies (1/6,400) were detected. Ultrasound-guided fine needle aspiration biopsy of the thyroid showed a heterogeneous lymphocytic population with a reactive appearance and occasional groups of epithelial cells with an immature squamous pattern, along with cytologic features of autoimmune thyroiditis. Immunocytochemistry was positive for CD20, CD3 and CD5. Immunoglobulin heavy chain gene rearrangement by polymerase chain reaction from cytologic material showed a polyclonal lymphoid population. External radiotherapy resulted in a significant reduction in the pelvic lesion. Four months after diagnosis, abdominal ultrasound displayed multiple hepatic metastasis, the patient's condition rapidly deteriorated, and she died about a month later.
  
  
  CONCLUSIONS
  This case had unique features and probably represented an AIDS-related lesion and distinct entity.
authors.affiliation: Department of Pathology, Hospital Sirio Libanes, São Paulo, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Mitteldorf
authors.forename: A C
authors.initials: AC
authors.lastname: Misiara
authors.forename: I E
authors.initials: IE
authors.lastname: de Carvalho
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003560:Cysts / Q000150:complications / Q000276:immunology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D013959:Thyroid Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis
chemical_list: D015703:Antigens, CD