title: Self-protection by cardiac myocytes against hypoxia and hyperoxia.
abstract: Cardiac muscle must maintain a continuous balance between its energy supply and work performed. An important mechanism involved in achievement of this balance is cross talk via chemical signals between cardiac myocytes and the cardiac muscle vascular system. This has been demonstrated by incubating isolated cardiac myocytes in different concentrations of oxygen and then assaying the conditioned media for vasoactive substances on isolated aortic rings and small-resistance arteries. With increasing oxygen concentrations above 6%, cardiac myocytes produce increasing amounts of angiotensin I, which is converted to angiotensin II by the blood vessel. The angiotensin II stimulates vascular endothelial cells to secrete endothelin and increase vascular tone. Below 6% oxygen, cardiac myocytes secrete adenosine, which acts directly on vascular smooth muscle to block the effect of alpha-adrenergic agonists and reduce vascular tone. In an intact heart, the net effect of these 2 regulatory systems would be the maintenance of oxygen concentration within a narrow range at the cardiac myocytes. By acting as oxygen sensors, cardiac myocytes modulate vascular tone according to the needs of the myocytes and reduce potential problems of hypoxia and extensive formation of reactive oxygen species.
authors.affiliation: Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA. bsg@mail.med.upenn.edu
authors.forename: S
authors.initials: S
authors.lastname: Winegrad
authors.forename: D
authors.initials: D
authors.lastname: Henrion
authors.forename: L
authors.initials: L
authors.lastname: Rappaport
authors.forename: J L
authors.initials: JL
authors.lastname: Samuel
mesh_terms: D000241:Adenosine / Q000378:metabolism / Q000502:physiology; D000809:Angiotensins / Q000502:physiology; D000818:Animals; D001011:Aorta / Q000502:physiology; D018496:Hyperoxia / Q000378:metabolism / Q000517:prevention & control*; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008638:Mesenteric Arteries / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D014655:Vascular Resistance / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000378:metabolism; D014665:Vasodilator Agents / Q000378:metabolism; D014666:Vasomotor System / Q000502:physiology
chemical_list: D000809:Angiotensins; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000241:Adenosine; D010100:Oxygen