title: Analysis of the H gene, the central untranslated region and the proximal coding part of the F gene of wild-type and vaccine canine distemper viruses.
abstract: This paper summarizes the results of the genetic analysis of several parts of the genome of canine distemper virus (CDV) field isolates and vaccine viruses. The haemagglutinin (H) gene analysis showed that recent viruses did not differ significantly from vaccine strains. The analysis of the long untranslated region between the matrix (M) and fusion (F) gene revealed distinct genetic heterogeneity. The putative F protein start codon AUG461 of vaccine strain Onderstepoort was found to be mutated in all wild-type isolates and in another vaccine strain. The proximal coding part of the F gene was well conserved. Phylogenetic analysis of this segment showed the presence of several cocirculating CDV genotypes.
authors.affiliation: Institute of Virology, Veterinary School Hannover, Germany. lhaas@viro.tiho-hannover.de
authors.forename: L
authors.initials: L
authors.lastname: Haas
authors.forename: H
authors.initials: H
authors.lastname: Liermann
authors.forename: T C
authors.initials: TC
authors.lastname: Harder
authors.forename: T
authors.initials: T
authors.lastname: Barrett
authors.forename: M
authors.initials: M
authors.lastname: Löchelt
authors.forename: V
authors.initials: V
authors.lastname: von Messling
authors.forename: W
authors.initials: W
authors.lastname: Baumgärtner
authors.forename: I
authors.initials: I
authors.lastname: Greiser-Wilke
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004217:Distemper Virus, Canine / Q000235:genetics*; D004285:Dogs; D005814:Genes, Viral; D005838:Genotype; D006389:Hemagglutinins, Viral / Q000235:genetics; D014760:Viral Fusion Proteins / Q000235:genetics; D014765:Viral Vaccines / Q000235:genetics*
chemical_list: C104413:H protein, Dolphin morbillivirus; D006389:Hemagglutinins, Viral; D014760:Viral Fusion Proteins; D014765:Viral Vaccines; C076619:F protein, Phocine distemper virus