Dietary potassium bicarbonate and potassium citrate have a greater inhibitory effect than does potassium chloride on magnesium absorption in wethers.
We addressed the question whether the type of anion in potassium salts affects magnesium absorption and the transmural potential difference by using wethers (n = 8) fed a control diet and diets supplemented with equimolar amounts of KHCO(3), KCl or K-citrate according to a Latin-square design. The control diet contained 10.9 g K/kg dry matter and the high K diets contained 41.3 g K/kg dry matter. Compared with the control diet, KHCO(3) and K-citrate significantly reduced apparent Mg absorption by 9.5 and 6.5%, respectively. Supplemental KCl tended to reduce (P = 0.070) group mean magnesium absorption by 5.5%. Consumption of supplemental KHCO(3) and K-citrate produced a significant increase in the transmural potential difference (serosal side = positive) by 17.1 and 20.7 mV, respectively, whereas the addition of KCl to the diet did not. The individual values for the four diets tended to show a negative correlation (r = -0.336, n = 32, P = 0.060) between the transmural potential difference and apparent magnesium absorption. We conclude that different potassium salts have different effects on magnesium absorption in ruminants as caused by different effects on the transmural potential difference.
Schonewille
J T
JT
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, The Netherlands.
Beynen
A C
AC
Van't Klooster
A T
AT
Wouterse
H
H
Ram
L
L
D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D008274:Magnesium / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D011189:Potassium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D019357:Potassium Citrate / Q000008:administration & dosage / Q000494:pharmacology*; D017680:Potassium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep
D001639:Bicarbonates; D017680:Potassium Compounds; D011189:Potassium Chloride; D019357:Potassium Citrate; C026329:potassium bicarbonate; D008274:Magnesium