title: Myosin structure: does the tail wag the dog?
abstract: Previous crystal structures of the myosin head have shown two different conformations, postulated to be the beginning and the end of the actomyosin power stroke. A new crystal structure reveals a dramatically different conformation; but how does this conformation fit into the force-generating cycle of actomyosin interactions?
authors.affiliation: Department of Biochemistry & Biophysics, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA. cooke@cgl.ucsf.edu
authors.forename: R
authors.initials: R
authors.lastname: Cooke
mesh_terms: D000205:Actomyosin / Q000737:chemistry / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D008954:Models, Biological; D008958:Models, Molecular; D009119:Muscle Contraction / Q000502:physiology; D009218:Myosins / Q000737:chemistry* / Q000502:physiology; D011487:Protein Conformation
chemical_list: D000255:Adenosine Triphosphate; D000205:Actomyosin; D009218:Myosins