title: Migratory ichthyosiform dermatosis with type 2 diabetes mellitus and insulin resistance.
abstract: BACKGROUND
  In addition to the well-defined hereditary primary ichthyoses, many sporadic or less well-defined keratinization disorders with or without systemic manifestations have been reported. Herein we describe ichthyosiform dermatosis associated with type 2 diabetes mellitus.
  
  
  METHODS
  The patients were members of a large Arab family with heavy consanguinity. Eighteen members were affected with a variously severe scaly disorder. They showed migratory polycyclic keratotic scaly plaques evolving into diffuse generalized scaling or complete remission. Acanthosis nigricans-like lesions were also noted, and there was an association with type 2 diabetes mellitus. A scarcity of intercorneocyte lamellae and reduction in lamellar body contents were observed.
  
  
  CONCLUSIONS
  We could not find a report of a similar dermatosis. Furthermore, an association between ichthyosis and diabetes has not been documented. Therefore, we believe that this may constitute a new entity.
authors.affiliation: Department of Dermatology, Rabin Medical Center, Petah Tiqva, Israel. gilyos@singnet.com.sg
authors.forename: G
authors.initials: G
authors.lastname: Yosipovitch
authors.forename: B
authors.initials: B
authors.lastname: Mevorah
authors.forename: M
authors.initials: M
authors.lastname: David
authors.forename: M
authors.initials: M
authors.lastname: Feinmesser
authors.forename: E
authors.initials: E
authors.lastname: Hodak
authors.forename: B
authors.initials: B
authors.lastname: Gabay
authors.forename: J
authors.initials: J
authors.lastname: Ammash
authors.forename: P M
authors.initials: PM
authors.lastname: Elias
mesh_terms: D000293:Adolescent; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree