title: Developmental patterns of cartilage.
abstract: The current state of knowledge of cartilage differentiation leaves many questions unanswered. This review provides an up-to-date examination of current thinking on the subject of developmental patterns in cartilage formation. We will discuss the current model of limb elongation as well as the molecular aspects of chondrogenesis and growth plate formation. This will then be compared with the limited information currently known about the molecular aspects of osteoarthritis.
authors.affiliation: Department of Orthopaedic Surgery, Barnes-Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway, St. Louis, Missouri 63110, USA. sandelll@msnotes.wustl.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Sandell
authors.forename: P
authors.initials: P
authors.lastname: Adler
mesh_terms: D000818:Animals; D019521:Body Patterning; D001842:Bone and Bones / Q000378:metabolism; D002356:Cartilage / Q000196:embryology*; D002450:Cell Communication; D002454:Cell Differentiation; D020219:Chondrogenesis; D005346:Fibroblast Growth Factors; D006132:Growth Plate; D053823:Hedgehog Proteins; D006801:Humans; D018878:Limb Buds / Q000196:embryology*; D010003:Osteoarthritis / Q000503:physiopathology; D010012:Osteogenesis; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D053823:Hedgehog Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D005346:Fibroblast Growth Factors