Olestra increases faecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Two patients with chloracne had concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of 144,000 and 26,000 pg/g blood lipids. Olestra, a non-digestible, lipophilic dietary fat substitute accelerated the patients' intestinal excretion of TCDD by eight to ten fold. This is sufficient to reduce the normally observed elimination half life of TCDD from about 7 years to 1-2 years.
Geusau
A
A
Tschachler
E
E
Meixner
M
M
Sandermann
S
S
Päpke
O
O
Wolf
C
C
Valic
E
E
Stingl
G
G
McLachlan
M
M
D000152:Acne Vulgaris / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000328:Adult; D001822:Body Burden; D004041:Dietary Fats / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood* / Q000493:pharmacokinetics; D005227:Fatty Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D005243:Feces / Q000737:chemistry; D005260:Female; D006207:Half-Life; D006801:Humans; D008657:Metabolic Clearance Rate; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects* / Q000097:blood* / Q000737:chemistry / Q000493:pharmacokinetics; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004041:Dietary Fats; D004785:Environmental Pollutants; D005227:Fatty Acids; D000072317:Polychlorinated Dibenzodioxins; D013395:Sucrose; C013692:sucrose polyester