title: [Effect of transurethral collagen injection for vesicoureteral reflux in patients with spina bifida].
abstract: BACKGROUND
  The effect of endoscopic injection of collagen was assessed in spina bifida patients with vesicoureteral reflux (VUR).
  
  
  METHODS
  Endoscopic collagen injection was carried out for grade II or worse VUR according to the international classification. Twenty-two ureters were studied in 6 boys and 8 girls (mean: 14.4 years) who were followed up over a period of at least 3 months (mean: 5 months) after surgery they all had a negative preoperative skin test for collagen and were investigated radiologically and urodynamically. Cystograpy was performed 1, 3 and 12 months after surgery and thereafter once a year to detect recurrence of VUR.
  
  
  RESULTS
  Anesthesia was not necessary in 4 patients. No adverse reactions occurred to the injection of collagen. VUR disappeared after 1 and 2 collagen injections in 17 (77%) and 2 (9%) ureters, respectively. The therapeutic effect of the single collagen injection showed no relationship to shape of the ureteral orifice, grade of VUR, compliance of the bladder, and presence of detrusor hyperreflexia.
  
  
  CONCLUSIONS
  Endoscopic treatment of VUR with collagen injection in spina bifida patients is a simple and less invasive method. We obtained satisfactory short-term results by this method. However, since the risk factor of recurrence remains unclear, sufficient investigation of long-term results is important to determine the role of this method in the treatment of VUR in patients with spina bifida.
authors.affiliation: Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Hirayama
authors.forename: H
authors.initials: H
authors.lastname: Kashiwai
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kawata
authors.forename: N
authors.initials: N
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Momose
authors.forename: T
authors.initials: T
authors.lastname: Shiomi
mesh_terms: D000283:Administration, Intravesical; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000008:administration & dosage*; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D016135:Spinal Dysraphism / Q000150:complications*; D014718:Vesico-Ureteral Reflux / Q000517:prevention & control* / Q000601:surgery
chemical_list: D003094:Collagen