An inverse correlation of HTLV-I viral load in CSF and intrathecal synthesis of HTLV-I antibodies in TSP/HAM.
The authors measured human T-cell lymphotrophic virus type I (HTLV-I) proviral load and intrathecal synthesis of antibodies to HTLV-I in CSF of 13 Brazilian patients with tropical spastic paraparesis/ HTLV-I-associated myelopathy (HAM). The authors also measured HTLV-I proviral load in peripheral blood mononuclear cells of five of these patients and found that it was 10- to 100-fold higher than that in CSF cells. The combination of HTLV-I proviral load and intrathecal synthesis of antibodies to HTLV-I appears to be a useful marker of disease progression. Patients with high viral load and no intrathecal synthesis of antibodies to HTLV-I had more rapidly progressing, serious clinical disease.
Puccioni-Sohler
M
M
Division of Neurology, Universidade Federal do Rio de Janeiro (HUCFF/UFRJ), Brazil.
Rios
M
M
Bianco
C
C
Zhu
S W
SW
Oliveira
C
C
Novis
S A
SA
Pombo-de-Oliveira
M S
MS
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology*; D002555:Cerebrospinal Fluid / Q000821:virology*; D004279:DNA, Viral / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000276:immunology*; D019562:Viral Load
D000914:Antibodies, Viral; D004279:DNA, Viral