Arylalkylamine drugs of abuse: an overview of drug discrimination studies.
Abused arylalkylamines fall into two major categories: the indolealkylamines, and the phenylalkylamines: These agents can be further subclassified on the basis of chemical structure. Examples of these agents possess hallucinogenic, stimulant, and other actions. Drug-discrimination techniques have been used to classify and investigate this large family of agents. Such studies have allowed the formulation of structure-activity relationships and investigations of mechanisms of action. Arylalkylamine designer drugs also possess the same or a combination of actions, and are being investigated by the same methods.
Glennon
R A
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Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond 23298-0540, USA.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D015198:Designer Drugs / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D006213:Hallucinogens / Q000494:pharmacology; D006801:Humans; D019966:Substance-Related Disorders / Q000523:psychology*
D000588:Amines; D000697:Central Nervous System Stimulants; D015198:Designer Drugs; D006213:Hallucinogens