title: Penile intraepithelial neoplasia overlying Kaposi's sarcoma lesions: role of viral synergy?
abstract: Several viral agents have been detected in the lesional tissue of Kaposi's sarcoma (KS). Their precise oncogenic role remains to be determined. A 32-year-old heterosexual man with acquired immunodeficiency syndrome (AIDS) who had penile lesions of KS with overlying epithelial changes characteristic of intraepithelial neoplasia associated with concurrent infection by human papillomavirus (HPV) and human herpesvirus 8 (HHV-8) is reported. The absence of viral DNA from uninvolved skin suggests that this coinfection is more than coincidental and may involve synergy between these viruses, as has already been suggested for HPV and herpes simplex 2 virus.
authors.affiliation: Department of Dermatology, Hôpital Universitaire Erasme, Brussels, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Simonart
authors.forename: J L
authors.initials: JL
authors.lastname: Dargent
authors.forename: P
authors.initials: P
authors.lastname: Hermans
authors.forename: I
authors.initials: I
authors.lastname: Fayt
authors.forename: E
authors.initials: E
authors.lastname: Hawaux
authors.forename: J P
authors.initials: JP
authors.lastname: Van Vooren
authors.forename: J C
authors.initials: JC
authors.lastname: Noel
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D027383:Papillomaviridae / Q000235:genetics; D010412:Penile Neoplasms / Q000150:complications / Q000473:pathology*; D010413:Penis / Q000737:chemistry / Q000473:pathology / Q000821:virology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000150:complications / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII