[New derivatives of 1-methyl-phthalazine with antimicrobial and fungistatic action].
In this paper we present the antimicrobial and antifungical action of some new salts of 1-methyl-phtalaziniums and their corresponding ylids. We also present conclusions concerning the relation between structure and biological activity. The test was performed using the diffusimetric method with rustless steel cylinders based on the diffusion on the tested substances on gelose surface. The salts of 1-methyl-phtalaziniums are always more active comparatively than their corresponding ylids. All the compounds but not all derivatives are more active on the Candida albicans.
Dima
S
S
Université Dunarea de Jos Galati, România.
Caprosu
M
M
Ungureanu
M
M
Grosu
G
G
Petrovanu
M
M
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010793:Phthalazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010793:Phthalazines