The next wave: protein tyrosine phosphatases enter T cell antigen receptor signalling.
Recent years have seen an exponentially increasing interest in the molecular mechanisms of signal transduction. Much of the focus has been on protein tyrosine kinase-mediated signalling, while the study of protein tyrosine phosphatases has lagged behind. We predict that the phosphatases will become a "hot topic" in the field within the next few years. This review summarizes the current state-of-the-art in our understanding of the structure, regulation and role of protein tyrosine phosphatases in T lymphocyte activation.
Mustelin
T
T
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. tmustelin@skcc.org
Brockdorff
J
J
Rudbeck
L
L
Gjörloff-Wingren
A
A
Han
S
S
Wang
X
X
Tailor
P
P
Saxena
M
M
D000818:Animals; D006801:Humans; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism*
D011948:Receptors, Antigen, T-Cell; D017027:Protein Tyrosine Phosphatases