title: Penetration of chloroform, trichloroethylene, and tetrachloroethylene through human skin.
abstract: In vitro dermal absorption was measured for three volatile organic compounds in dilute aqueous solution through freshly prepared and previously frozen human skin. The permeability coefficients at 26 degrees C for chloroform (0.14 cm/h) and trichloroethylene (0.12 cm/h) were similar but much larger than that for tetrachloroethylene (0.018 cm/h). Storage of the skin at -20 degrees C did not significantly affect the penetration of these chemicals. The dermal absorption of chloroform through freshly prepared human skin was not changed significantly by pretreatment of the skin with commonly used consumer products (moisturizer, baby oil, insect repellent, sunscreen); however, the permeability coefficient was found to increase from 0.071 cm/h at 11 degrees C to 0.19 cm/h at 50 degrees C. These data suggest that exposure estimates for chloroform and other contaminants in water should consider the appropriate exposure scenario to properly assess the dermal dose.
authors.affiliation: Health Canada, Bureau of Chemical Hazards, Ottawa, Ontario. jamie_nakai@hc-sc.gc.ca
authors.forename: J S
authors.initials: JS
authors.lastname: Nakai
authors.forename: P B
authors.initials: PB
authors.lastname: Stathopulos
authors.forename: G L
authors.initials: GL
authors.lastname: Campbell
authors.forename: I
authors.initials: I
authors.lastname: Chu
authors.forename: A
authors.initials: A
authors.lastname: Li-Muller
authors.forename: R
authors.initials: R
authors.lastname: Aucoin
mesh_terms: D000293:Adolescent; D000328:Adult; D002725:Chloroform / Q000493:pharmacokinetics*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology*; D012997:Solvents / Q000493:pharmacokinetics*; D013550:Swimming; D013696:Temperature; D013750:Tetrachloroethylene / Q000493:pharmacokinetics*; D014241:Trichloroethylene / Q000493:pharmacokinetics*
chemical_list: D012997:Solvents; D014241:Trichloroethylene; D002725:Chloroform; D013750:Tetrachloroethylene