No evidence to support the association of the potassium channel gene hSKCa3 CAG repeat with schizophrenia or bipolar disorder in the Irish population.
Anticipation has attracted much interest and has been demonstrated in several neuropsychiatric disorders. For some disorders, this phenomenon has been found to correlate with the repeat number in large and unstable repeats (CAG/CTG). In addition, case control studies have suggested an increase in triplet repeat size in the psychoses. Recently, it was reported that the larger alleles (longer than 19 repeats) of the second potassium channel gene hSKCa3 are associated with schizophrenia in European and American samples. A similar trend, though not statistically significant, was also seen in bipolar disorder samples. This was further supported by an independent UK study.1 In this investigation, we have examined Irish familial schizophrenic patients, bipolar affective disorder patients and ethnically matched controls in an effort to replicate these findings. No significant differences between the patients and the control groups were observed. In addition, linkage analyses in the multiplex schizophrenic families showed no evidence for linkage or linkage disequilibrium. We concluded that the polymorphism of the second CAG repeat of the hSKCa3 gene is not a risk factor in schizophrenia or bipolar disorder, at least in the Irish population.
Hawi
Z
Z
Department of Psychiatry and Genetics, Trinity College, Dublin, Eire. zhhawi@tcd.ie
Mynett-Johnson
L
L
Murphy
V
V
Straub
R E
RE
Kendler
K S
KS
Walsh
D
D
McKeon
P
P
Gill
M
M
D001714:Bipolar Disorder / Q000235:genetics*; D015331:Cohort Studies; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007494:Ireland; D008297:Male; D009479:Neuropeptides / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D015221:Potassium Channels / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D051640:Small-Conductance Calcium-Activated Potassium Channels; D018911:Trinucleotide Repeats
C406328:KCNN3 protein, human; D009479:Neuropeptides; D015221:Potassium Channels; D051640:Small-Conductance Calcium-Activated Potassium Channels