title: Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity.
abstract: A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free omega-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit.
authors.affiliation: Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China.
authors.forename: W M
authors.initials: WM
authors.lastname: Dai
authors.forename: C W
authors.initials: CW
authors.lastname: Chow
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: A
authors.initials: A
authors.lastname: Ishii
authors.forename: C W
authors.initials: CW
authors.lastname: Lau
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Hamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Nishimoto
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D004279:DNA, Viral / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D007364:Intercalating Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis*; D013450:Sulfones / Q000138:chemical synthesis*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004279:DNA, Viral; D007364:Intercalating Agents; D009281:Naphthalenes; D013450:Sulfones