title: Natural Product Synthesis on Polymeric Supports-Synthesis and Biological Evaluation of an Indolactam Library.
abstract: Potent activators of protein kinase C in fibroblasts: This property was determined for several indolactam V analogues (1) with a new cell-based assay system. This tumor-promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, D-44227 Dortmund (Germany).
authors.initials: B
authors.lastname: Meseguer
authors.initials: D
authors.lastname: Alonso-Díaz
authors.initials: N
authors.lastname: Griebenow
authors.initials: T
authors.lastname: Herget
authors.initials: H
authors.lastname: Waldmann