Cancer biology: extracellular proteinases in malignancy.
Secreted, matrix-degrading proteinases have been viewed as contributing to tumor metastasis. A recent study indicates that the gene for one of these enzymes, the matrix metalloproteinase stromelysin-1, can actually cause cancer when expressed in transgenic mice.
Matrisian
L M
LM
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA. Lynn.Matrisian@mcmail.Vanderbilt.edu
D000818:Animals; D015870:Gene Expression; D019278:Matrix Metalloproteinase 3 / Q000235:genetics / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000235:genetics; D009857:Oncogenes
D020782:Matrix Metalloproteinases; D019278:Matrix Metalloproteinase 3