Safety and immunogenicity of hepatitis B vaccine ButaNG in adults
Recombinant yeast-derived hepatitis B vaccine manufactured by Instituto Butantan was administered in two groups of adult volunteers (I, II) following two different schedules of immunization. In the first trial (10 &mgr;g doses and 0, 1, 3 months vaccination schedule) 106 individuals completed the full immunization program. The results of seroconversion by age group varied from 70 to 100% and the GMT from 46.5 to 124.9 mIU mL-1. In the second trial with 68 individuals (for dosage comparison and 0, 1, 6 months vaccination schedule) indicated that the vaccine formulated in 20 &mgr;g was more effective than in 10 &mgr;g. The adverse reactions observed in the vaccinees were less frequent than the ones previously found since the introduction of similar vaccines.
Ioshimoto
LM
Centro de Biotecnologia, Instituto Butantan, Sao Paulo, SP, 05503-900, Brazil.
Rissato
ML
Bonilha
VS
Miyaki
C
Raw
I
Granovski
N