Graft-versus-myeloma after withdrawal of immunosuppression following allogeneic peripheral stem cell transplantation.
There is growing evidence for a graft-versus-myeloma effect following allogeneic stem cell transplantation. We add to this evidence by reporting complete remission achieved by withdrawal of immunosuppression in a patient with multiple myeloma progressing after HLA-identical sibling peripheral stem cell transplantation. De novo chronic graft-versus-host disease coincided with the anti-myeloma effect and responded to treatment. The patient remains in complete remission 3 years after transplant.
Libura
J
J
Department of Internal Medicine, Kantonsspital Basel, Switzerland.
Hoffmann
T
T
Passweg
J
J
Gregor
M
M
Favre
G
G
Tichelli
A
A
Gratwohl
A
A
D000328:Adult; D005260:Female; D020350:Graft vs Tumor Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy*; D014184:Transplantation, Homologous