A randomized double-blind study assessing 4 versus 8 mg. doxazosin for benign prostatic hyperplasia.
OBJECTIVE
We compare the efficacy of 4 versus 8 mg. doxazosin for benign prostatic hyperplasia.


METHODS
A total of 82 patients with benign prostatic hyperplasia successfully treated with 4 mg. doxazosin were randomized in a double-blind fashion to take 4 or 8 mg. Patients were evaluated with American Urological Association (AUA) symptom score, Boyarsky score, uroflowmetry and side effect profile before, and 1 and 3 months following randomization.


RESULTS
Of the patients 42 and 40 were randomized to receive 4 and 8 mg. doxazosin, respectively. Both groups were similar with respect to patient age, baseline Boyarsky and AUA symptom scores, and baseline maximum urinary flow rate. At 3 months mean improvement from baseline plus or minus standard deviation in Boyarsky score was 0.6 +/- 6.5 and 4.9 +/- 6.6 in the 4 and 8 mg. groups (p <0.05), respectively, mean improvement in AUA symptom score was 1.6 +/- 5.3 and 5.3 +/- 8.0 (p <0.05), and mean maximum flow rate difference was -0.6 +/- 6.4 and +1.4 +/- 7.9 (p >0.05). Of the patients 7 and 8 in the 4 and 8 mg. groups dropped out of the study, and there were no statistical differences in side effects between dosages.


CONCLUSIONS
A dose of 8 mg. doxazosin was more efficacious than 4 mg. and the side effects associated with both dosages appeared to be similar. The 8 mg. dose should be tried in patients who have not achieved an adequate therapeutic response to 4 mg. and are tolerating the medication. Consideration should be given to increasing the dosage to 8 mg. in patients who are clinically improved at lower dosages.
MacDiarmid
S A
SA
Department of Urology, University of Arkansas College of Medicine and John L. McClellan Memorial Veteran's Administration Hospital, Little Rock, USA.
Emery
R T
RT
Ferguson
S F
SF
McGuirt-Franklin
R
R
McIntyre
W J
WJ
Johnson
D E
DE
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage*; D000368:Aged; D004311:Double-Blind Method; D017292:Doxazosin / Q000008:administration & dosage*; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000188:drug therapy*
D000317:Adrenergic alpha-Antagonists; D017292:Doxazosin