[Effects of halogen derivative hydrocarbons on radiation damage of biological membranes].
Sharp increase of radiation-induced damages of isolated erythrocyte membrane lipids and proteins upon irradiation in presence of some halogen derivative hydrocarbon are shown. On chloroform and CCl4 examples it is shown that marked effects displayed under relatively low (submillimoles) concentrations and radiation doses that induced only insignificant oxidative membrane damages in absence of modifiers. The data are received which evidenced in favour of decisive role in these processes of halogenated organic radicals forming under one-electron reduction of halogen derivative hydrocarbons by hydrated electrons.
Vorobeĭ
A V
AV
Institute of Photobiology, Belarus National Academy of Sciences, Minsk.
Shukanova
N A
NA
Pinchuk
S V
SV
Vorobeĭ
P A
PA
D002251:Carbon Tetrachloride / Q000494:pharmacology; D002588:Cesium Radioisotopes; D002725:Chloroform / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000032:analysis / Q000528:radiation effects*; D008565:Membrane Proteins / Q000032:analysis / Q000528:radiation effects*; D010084:Oxidation-Reduction; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D013050:Spectrometry, Fluorescence
D002588:Cesium Radioisotopes; D006843:Hydrocarbons, Chlorinated; D008563:Membrane Lipids; D008565:Membrane Proteins; D002725:Chloroform; D002251:Carbon Tetrachloride