[The genotype-based haplotype relative risk and transmission disequilibrium test analyses of familial febrile convulsions].
OBJECTIVE
To confirm the linkage of familial febrile convulsions to the short arm of chromosome 6(6p) or the long arm of chromosome 8(8q).


METHODS
The authors finished genotyping of Pst I locus on the coding region of heat shock protein (HSP) 70, 5'untranslated region of HSP70-1, 3' untranslated region of HSP70-2, D8S84 and D8S85. The data were processed by the genotype-based haplotype relative risk(GHRR) and transmission disequilibrium test(TDT) methods in PPAP.


RESULTS
Some signs of association and disequilibrium between D8S85 and FC were shown by GHRR and TDT.


CONCLUSIONS
A suspect linkage of familial febrile convulsions to the long arm of chromosome 8 has been proposed.
Qi
Y
Y
Department of Pediatrics, The First Teaching Hospital of Beijing Medical University, Beijing, 100034 P. R. China. pedlab@public.east.cn.net
Wu
X
X
Guo
Z
Z
Zhang
J
J
Pan
H
H
Li
M
M
Bao
X
X
Peng
J
J
Zou
L
L
Lin
Q
Q
D002896:Chromosomes, Human, Pair 6; D002898:Chromosomes, Human, Pair 8; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D012306:Risk; D003294:Seizures, Febrile / Q000235:genetics*