[Recurrent hepatitis in oral anticoagulation: coumarin-induced hepatitis].
Coumarin hepatotoxicity resulting in a cholestatic or cytolytic hepatitis is a rare side effect in oral anticoagulant therapy, but has to be considered in any patient receiving coumarin treatment if hepatitis is diagnosed. Substitution with an other coumarin derivative is sometimes feasable, although cross-reactions between coumarin derivatives have been observed.
Kremer Hovinga
J A
JA
Hämatologisches Zentrallabor der Universität, Inselspital, Bern.
Wuillemin
W A
WA
D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010644:Phenprocoumon / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D013924:Thrombophlebitis / Q000188:drug therapy*
D000925:Anticoagulants; D010644:Phenprocoumon