title: Epidemiology of acquisition and clearance of cervical human papillomavirus infection in women from a high-risk area for cervical cancer.
abstract: Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in São Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6-15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5-11.9). Median retention times were 8.1 months (95% CI, 7.8-8.3) for oncogenic types and 4.8 months (95% CI, 3.9-5.6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13-14 months), nononcogenic-type infections lasted longer (10. 2 months) among younger (<35 years old) than in older women (5.6 months).
authors.affiliation: Department of Oncology, McGill University, Montreal, QC, Canada H2W 1S6. eduardof@oncology.lan.mcgill.ca
authors.forename: E L
authors.initials: EL
authors.lastname: Franco
authors.forename: L L
authors.initials: LL
authors.lastname: Villa
authors.forename: J P
authors.initials: JP
authors.lastname: Sobrinho
authors.forename: J M
authors.initials: JM
authors.lastname: Prado
authors.forename: M C
authors.initials: MC
authors.lastname: Rousseau
authors.forename: M
authors.initials: M
authors.lastname: Désy
authors.forename: T E
authors.initials: TE
authors.lastname: Rohan
mesh_terms: D000328:Adult; D017677:Age Distribution; D001938:Brazil / Q000453:epidemiology; D002584:Cervix Uteri / Q000821:virology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000821:virology