title: The role of surgery in the treatment of liver metastases for colorectal cancer patients.
abstract: OBJECTIVE
  Liver metastases deriving from colorectal cancer can be treated with curative intention in a select number of patients. Controversy does, however, persist pertaining to the impact of adjuvant treatment strategies. The aim of this study is to elucidate upon the various treatment modalities for patients suffering from liver metastases of colorectal primary tumor as well as to provide a rationale for surgical and adjuvant treatment.
  
  
  METHODS
  From November 1987 to September 1998, a total of 449 consecutive patients suffering from liver metastases deriving from a colorectal cancer were documented at our institution in a prolective study. Prognostic factors providing the most beneficial outcome (whether with surgical and/or adjuvant treatment modalities) were analyzed by univariate and multivariate analysis.
  
  
  RESULTS
  Whenever possible, curative (R0) surgical resection of colorectal liver metastases provides the most benefit to the patient. Multivariate analysis revealed tumor infiltration of the lymph nodes of the hepatoduodenal ligament and metachronous occurrence of liver metastases as most independent factors related to survival.
  
  
  CONCLUSIONS
  Adjuvant post-operative chemotherapy fails to significantly improve survival following resection of liver metastases when compared to the liver resection only group. In patients with unresectable metastases, regional arterial chemotherapy did not improve survival significantly when compared with systemic chemotherapy.
authors.affiliation: Department of Surgery, Technische Universität München, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Harms
authors.forename: T
authors.initials: T
authors.lastname: Obst
authors.forename: S
authors.initials: S
authors.lastname: Thorban
authors.forename: R
authors.initials: R
authors.lastname: Busch
authors.forename: U
authors.initials: U
authors.lastname: Fink
authors.forename: C D
authors.initials: CD
authors.lastname: Heidecke
authors.forename: J D
authors.initials: JD
authors.lastname: Roder
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate