Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis.
The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.
Fernandez-Arquero
M
M
Department of Immunology, San Carlos University Hospital, Madrid, Spain.
Arroyo
R
R
Rubio
A
A
Martin
C
C
Vigil
P
P
Conejero
L
L
Figueredo
M A
MA
de la Concha
E G
EG
D000483:Alleles; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha