title: Fluoride in whole saliva, parotid ductal saliva and plasma in children.
abstract: The purpose was to investigate the relation between fluoride concentrations in whole saliva, parotid ductal saliva, and plasma in 5- to 10-year-old children (n = 17). Two stimulated whole-saliva samples were obtained from each child. Before the second sample was obtained, each child rinsed several times with a total of 100 ml of deionized water. Parotid saliva samples were obtained by use of a Lashley cup. Fluoride concentrations were determined by fluoride ion-specific electrode after diffusion with hexamethyldisiloxane. Rinsing with deionized water did not significantly reduce the fluoride concentration in whole saliva. The whole-saliva fluoride concentrations were not significantly related to those in plasma or parotid ductal saliva. Parotid fluoride concentrations, however, were significantly related to plasma fluoride concentrations (p < 0.0001) by a proportionality constant of 0.80. It was concluded that parotid salivary fluoride concentrations can be used to estimate plasma fluoride concentrations in 5- to 10-year-old children.
authors.affiliation: Department of Oral Biology, Medical College of Georgia, Atlanta 30912-1210, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Whitford
authors.forename: J E
authors.initials: JE
authors.lastname: Thomas
authors.forename: S M
authors.initials: SM
authors.lastname: Adair
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005459:Fluorides / Q000032:analysis*; D006801:Humans; D008297:Male; D009067:Mouthwashes; D010306:Parotid Gland / Q000378:metabolism*; D010949:Plasma / Q000737:chemistry*; D012463:Saliva / Q000737:chemistry*; D013048:Specimen Handling / Q000379:methods; D014680:Veins; D014867:Water
chemical_list: D009067:Mouthwashes; D014867:Water; D005459:Fluorides