title: Botulinum toxin treatment of hemifacial spasm and blepharospasm: objective response evaluation.
abstract: Twenty seven patients with hemifacial spasm (HFS) and sixteen patients with blepharospasm (BS) having mean Jankovic disability rating scale score of 2.56+0.58 SD and 2.81+0.54 SD, respectively, were treated with botulinum toxin A (BTX-A) injections. The total number of injection sessions were ninety one with relief response in 98.91%. The mean improvement in function scale score was 3.78+0.64 SD and 3.29+1.07 SD respectively, in HFS and BS groups. The clinical benefit induced by botulinum toxin lasted for a mean of 4.46+3.11 SD (range 2 to 13) months in HFS group and 2.66+1.37 SD (range 1 to 6) months, in BS groups. Transient ptosis was seen in 4.39% of total ninety one injection sessions. These findings show that local botulinum toxin treatment provides effective, safe and long lasting relief of spasms.
authors.affiliation: Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India.
authors.forename: A
authors.initials: A
authors.lastname: Thussu
authors.forename: C R
authors.initials: CR
authors.lastname: Barman
authors.forename: S
authors.initials: S
authors.lastname: Prabhakar
mesh_terms: D000328:Adult; D000368:Aged; D001764:Blepharospasm / Q000188:drug therapy*; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005500:Follow-Up Studies; D019569:Hemifacial Spasm / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A