title: Effect of longeing and glucosamine supplementation on serum markers of bone and joint metabolism in yearling quarter horses.
abstract: The effect of longeing and glucosamine supplementation on known biological markers of joint disease was studied in yearling quarter horses. Twenty-one yearling quarter horses were randomly assigned to one of 4 treatments: 1) longeing (longeing 20 min daily) supplement control (LN); 2) longeing/glucosamine (LG); 3) walking (mechanical walker for 120 min daily (WN)); and 4) walking/glucosamine (WG). Oral glucosamine was administered at 5.5 g b.i.d. weeks 1-4, 3.5 g b.i.d. during weeks 5-6, and 2.0 g b.i.d. during weeks 7-8. Serum was obtained weekly for 8 wk and analyzed for keratan sulfate and osteocalcin concentrations. Walked horses receiving glucosamine showed slight elevation in serum keratan sulfate compared to controls (P = 0.04). Glucosamine or longeing exercise had no significant effect (6 > or = 0.08) on serum osteocalcin concentrations. Under these conditions, longeing and/or glucosamine supplementation did not significantly alter serum concentrations of keratan sulfate or osteocalcin.
authors.affiliation: Department of Animal Science, Michigan State University, East Lansing 48824, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Fenton
authors.forename: M W
authors.initials: MW
authors.lastname: Orth
authors.forename: K A
authors.initials: KA
authors.lastname: Chlebek-Brown
authors.forename: B D
authors.initials: BD
authors.lastname: Nielsen
authors.forename: C D
authors.initials: CD
authors.lastname: Corn
authors.forename: K S
authors.initials: KS
authors.lastname: Waite
authors.forename: J P
authors.initials: JP
authors.lastname: Caron
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D005944:Glucosamine / Q000008:administration & dosage / Q000494:pharmacology*; D006734:Horse Diseases / Q000503:physiopathology / Q000517:prevention & control*; D006736:Horses; D007592:Joint Diseases / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D010805:Physical Conditioning, Animal
chemical_list: D005944:Glucosamine