title: A new statistical method for transfer coefficient calculations in the framework of the general multiple-compartment model of transport for radionuclides in biological systems.
abstract: A new and simple statistical procedure (STATFLUX) for the calculation of transfer coefficients of radionuclide transport to animals and plants is proposed. The method is based on the general multiple-compartment model, which uses a system of linear equations involving geometrical volume considerations. By using experimentally available curves of radionuclide concentrations versus time, for each animal compartment (organs), flow parameters were estimated by employing a least-squares procedure, whose consistency is tested. Some numerical results are presented in order to compare the STATFLUX transfer coefficients with those from other works and experimental data.
authors.affiliation: Instituto de Física, Universidade de São Paulo, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Garcia
authors.forename: J D
authors.initials: JD
authors.lastname: Arruda-Neto
authors.forename: M V
authors.initials: MV
authors.lastname: Manso
authors.forename: O M
authors.initials: OM
authors.lastname: Helene
authors.forename: V R
authors.initials: VR
authors.lastname: Vanin
authors.forename: O
authors.initials: O
authors.lastname: Rodriguez
authors.forename: J
authors.initials: J
authors.lastname: Mesa
authors.forename: V P
authors.initials: VP
authors.lastname: Likhachev
authors.forename: J W
authors.initials: JW
authors.lastname: Filho
authors.forename: A
authors.initials: A
authors.lastname: Deppman
authors.forename: G
authors.initials: G
authors.lastname: Perez
authors.forename: F
authors.initials: F
authors.lastname: Guzman
authors.forename: S P
authors.initials: SP
authors.lastname: de Camargo
mesh_terms: D000818:Animals; D001692:Biological Transport; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological; D015233:Models, Statistical; D010944:Plants / Q000378:metabolism; D011868:Radioisotopes / Q000493:pharmacokinetics*; D012984:Software; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes