title: Monocular horizontal OKN in observers with early- and late-onset strabismus.
abstract: Several reports on monocular optokinetic nystagmus (OKN) in observers with strabismus have found that asymmetry of OKN tends to occur in both eyes of observers with an early onset of strabismus but only in the deviating eye of those with a later onset of strabismus. Our objective was to quantify and compare the magnitude of the OKN asymmetry in each eye as a function of observer's age at onset of strabismus. We studied monocular OKN in ten observers with early-onset (up to 24 months of age), seven observers with late-onset (after 24 months of age) unilateral strabismus, and 12 normally sighted control observers. In the deviating eye, observers with early-onset strabismus showed large OKN asymmetries in favour of nasalward motion while observers with late-onset strabismus showed smaller OKN asymmetries in that eye. The majority of early- and late-onset observers showed near normal OKN in the non-deviating eye although the early-onset observers showed bilateral asymmetries more often. These findings may be due to both age at onset of strabismus and chronological age and are discussed in terms of the issue of plasticity or recovery of function.
authors.affiliation: Centre for Vision Research, York University, North York, Ont., Canada.
authors.forename: J K
authors.initials: JK
authors.lastname: Steeves
authors.forename: M J
authors.initials: MJ
authors.lastname: Reed
authors.forename: M J
authors.initials: MJ
authors.lastname: Steinbach
authors.forename: S P
authors.initials: SP
authors.lastname: Kraft
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D017120:Nystagmus, Optokinetic / Q000502:physiology*; D015588:Observer Variation; D013285:Strabismus / Q000503:physiopathology*; D015349:Vision, Monocular / Q000502:physiology*