title: Enantiomeric purity determination of propranolol by capillary electrophoresis using dual cyclodextrins and a polyacrylamide-coated capillary.
abstract: The use of a chirally selective capillary electrophoresis method is reported for the enantioselective purity determination of propranolol drug substance. The method employed a combination of both charged and neutral cyclodextrin. An internally coated capillary was used to suppress electroosmotic flow and potential peak tailing. The method was capable of monitoring below 0.1% m/m of the undesired impurity. Acceptable validation data was also obtained for recovery, linearity, and for both short and long-term injection precision.
authors.affiliation: Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, West Yorkshire, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Assi
authors.forename: B J
authors.initials: BJ
authors.lastname: Clark
authors.forename: K D
authors.initials: KD
authors.lastname: Altria
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D011433:Propranolol / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D011433:Propranolol