title: The advisability of implementing cholesterol screening in school-age children and adolescents with a family history of cardiovascular disease and hyperlipidaemia.
abstract: BACKGROUND
  The family basis of coronary heart disease is well recognized and it is important for family physicians to assess whether children have elevated cholesterol levels.
  
  
  OBJECTIVE
  We aimed to evaluate the advisability of implementing cholesterol screening in children with a family history of cardiovascular disease and hyperlipidaemia.
  
  
  METHODS
  We conducted a cross-sectional study in Taiwan from February to June 1996. There were 47,800 students in the population. A total of 4520 students were recruited by two-stage sampling. All the participants were required to fill out a structured questionnaire.
  
  
  RESULTS
  The response rate was 92.5%. Our results show that 16-18% of the children had a positive family history of cardiovascular disease or hyperlipidaemia. Children with a family history of hyperlipidaemia were significantly more likely to have elevated total cholesterol and low-density lipoprotein cholesterol than those without such a history (both odds ratios: 1.4, P < 0.05). Positive predictive values of hyperlipidaemia were less than 13% based on family history. More than 75% of children with abnormal lipid levels would be missed.
  
  
  CONCLUSIONS
  The data suggest that parents' self-reported family history is an ineffective means of identifying children with elevated serum lipid levels in Taiwan. Further research and modification of current National Cholesterol Education Program Panel guidelines for selective cholesterol screening in children may be warranted.
authors.affiliation: Department of Family Medicine, China Medical College Hospital, Taichung, Taiwan.
authors.forename: C S
authors.initials: CS
authors.lastname: Liu
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: H C
authors.initials: HC
authors.lastname: Shih
authors.forename: T C
authors.initials: TC
authors.lastname: Li
mesh_terms: D000704:Analysis of Variance; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D008297:Male; D008403:Mass Screening; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015995:Prevalence; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D013624:Taiwan / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol