title: [A case of common variable immunodeficiency that responded to long-term erythromycin chemotherapy].
abstract: A 32-year-old woman with common variable immunodeficiency (CVID) accompanied by sinopulmonary infection was evaluated for purulent sputum, cough, and nasal obstruction that did not respond to regular intravenous immunoglobin (IVIG) infusion. Chest X-ray films revealed bronchiectasis affecting both lung bases, and a bacteriological examination of sputum was positive for Pseudomonas aeruginosa. Long-term chemotherapy with erythromycin (EM) was started, and the patient's respiratory symptoms gradually subsided. Sinopulmonary infection is the dominant clinical complication in patients with CVID. This case suggested that long-term EM chemotherapy is useful for the treatment of IVIG-refractory sinopulmonary infection associated with CVID.
authors.affiliation: Department of Internal Medicine II, Nara Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Teranishi
authors.forename: T
authors.initials: T
authors.lastname: Majima
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: E
authors.initials: E
authors.lastname: Yoshimoto
authors.forename: M
authors.initials: M
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: K
authors.initials: K
authors.lastname: Hamada
authors.forename: K
authors.initials: K
authors.lastname: Mikasa
authors.forename: N
authors.initials: N
authors.lastname: Narita
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017074:Common Variable Immunodeficiency / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004917:Erythromycin / Q000008:administration & dosage*; D005260:Female; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin