title: Presumed congenital ocular toxoplasmosis in two successive siblings.
abstract: We present the cases of 2 consecutive siblings with bilateral macular lesions, for which there is strong clinical and laboratory evidence supporting the diagnosis of congenital ocular toxoplasmosis. These cases raise the possibility of maternal parasitemia during Toxoplasma gondii reinfection, leading to transmission to the fetus and congenital ocular toxoplasmosis despite prior immunity and lack of an immune disturbance in the mother.
authors.affiliation: Department of Ophthalmology, Athens University School of Medicine, Athens, Greece. ladas@ath.forthnet.gr
authors.forename: I D
authors.initials: ID
authors.lastname: Ladas
authors.forename: C L
authors.initials: CL
authors.lastname: Rallatos
authors.forename: C S
authors.initials: CS
authors.lastname: Kanaki
authors.forename: A G
authors.initials: AG
authors.lastname: Damanakis
authors.forename: P K
authors.initials: PK
authors.lastname: Zafirakis
authors.forename: G
authors.initials: G
authors.lastname: Rallatos
mesh_terms: D000293:Adolescent; D000328:Adult; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014126:Toxoplasmosis, Ocular / Q000151:congenital* / Q000235:genetics* / Q000473:pathology