title: Receptors for innate pathogen defence in insects are normal activation receptors for specific immune responses in mammals.
abstract: The Toll genes code for activation receptors for innate microbial defence in insects and have recently been found to code for the Lps receptor in murine B lymphocytes. In this study, I will present evidence to show that this family of receptors are responsible for induction of specific thymus-independent immune responses in mice. T cells do not possess these pattern-recognizing receptors, but they possess structures capable of delivering activation signals to these receptors on B cells.
authors.affiliation: Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Möller
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D029721:Drosophila Proteins; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D007313:Insecta / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000378:metabolism; D008322:Mammals / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018448:Models, Immunological; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D051193:Toll-Like Receptors
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors