Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat.
Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by approximately 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclamide (i.c.v.) abolished salvage only in the SHR rat. While blockade of K-ATP channels failed to abolish salvage in WKY and Fisher rats, participation of potassium channels in neurogenic neuroprotection cannot be excluded.
Golanov
E V
EV
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 411 East 69th Street, KB410, New York, NY 10021, USA. egolano@mail.med.cornell.edu
Christensen
J D
JD
Reis
D J
DJ
D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000503:physiopathology* / Q000517:prevention & control*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D004558:Electric Stimulation; D005905:Glyburide / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D026902:Potassium Channel Blockers; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D005905:Glyburide