Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X.
The effects of a beta blocker (atenolol), a calcium antagonist (amlodipine), and a nitrate (isosorbide-5-mononitrate) on anginal symptoms in 10 patients with syndrome X were assessed in a crossover, double-blind, randomized trial. Only atenolol was found to significantly improve chest pain episodes, suggesting that it should be the preferred drug when starting pharmacologic treatment of patients with syndrome X.
Lanza
G A
GA
Istituto di Cardiologia Cardiologia, Universitá Cattolica, Roma, Italy. g.a.lanza@eudoramail.com
Colonna
G
G
Pasceri
V
V
Maseri
A
A
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D017311:Amlodipine / Q000627:therapeutic use*; D000704:Analysis of Variance; D001262:Atenolol / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D017566:Microvascular Angina / Q000188:drug therapy*; D008875:Middle Aged; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000319:Adrenergic beta-Antagonists; D014665:Vasodilator Agents; D017311:Amlodipine; D001262:Atenolol; D007548:Isosorbide Dinitrate