title: Orbitofrontal cortex dysfunction in obsessive-compulsive disorder? I. Alternation learning in obsessive-compulsive disorder: male-female comparisons.
abstract: BACKGROUND
  We have previously reported a significant negative correlation between severity of symptoms and performance of an alternation learning task in female obsessive-compulsive disorder (OCD) patients. The present study was aimed at exploring this relationship between alternation learning and OCD symptom severity in male OCD patients.
  
  
  RESULTS
  Eighteen female obsessive-compulsive disorder patients and 14 male non-depressed, drug free, OCD patients participated in the study. Measures of dorsolateral prefrontal function (Wisconsin Card Sorting Test) and orbitofrontal cortex function (object alternation learning) showed no significant differences between the sexes. The relationship between orbitofrontal cortex function and severity of OC symptoms was significantly different between the sexes (z=2.44. P=0.007). While this correlation was negative in the females it was positive in the males.
  
  
  CONCLUSIONS
  These results may indicate sexual dimorphism in OCD.
authors.affiliation: Division of Psychiatry, The Chaim Sheba Medical Center, Tel-Hashomer and Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Zohar
authors.forename: H
authors.initials: H
authors.lastname: Hermesh
authors.forename: A
authors.initials: A
authors.lastname: Weizman
authors.forename: H
authors.initials: H
authors.lastname: Voet
authors.forename: R
authors.initials: R
authors.lastname: Gross-Isseroff
mesh_terms: D000328:Adult; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007858:Learning; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors