Effects of OspA vaccination on Lyme disease serologic testing.
This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who developed early Lyme disease despite vaccination.
Aguero-Rosenfeld
M E
ME
Department of Pathology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA. maria_aguero-rosenfeld@nymc.edu
Roberge
J
J
Carbonaro
C A
CA
Nowakowski
J
J
Nadelman
R B
RB
Wormser
G P
GP
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000954:Antigens, Surface / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008074:Lipoproteins; D008193:Lyme Disease / Q000175:diagnosis* / Q000276:immunology* / Q000517:prevention & control; D012698:Serologic Tests; D014611:Vaccination
D000907:Antibodies, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008074:Lipoproteins; C072045:OspA protein