title: [Vitamin deficiencies and hypervitaminosis].
abstract: There have recently been very few deficiencies with respect to fat soluble and water soluble vitamins in Japan All-trans-retinoic acid as induction or maintenance treatment improves disease free and overall survival against acute promyelocytic leukemia. In the isolated vitamin E deficiencies gene mutation has been cleared for alpha-tocopherol transferprotein. Recently, a relation of nutritional vitamin K intake and senile osteoporosis in women was epidemiologically demonstrated on a prospective study. Thiamin was yet noticed as development of deficiency in alcoholism, while the importance of supplemental folic acid during pregnancy has become especially clear in light of studies showing that folic acid supplements reduce the risk of neural tube defects in the fetus. With respect to hypervitaminosis, the Council for Responsible Nutrition (CRN), USA, has established safe intakes by identifying the NOAEL (No Observed Adverse Effect Level) and LOAEL (Lowest Observed Adverse Effect Level). Summaries of NOAEL and LOAEL for individual vitamins were shown.
authors.affiliation: Seikeikai Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Mino
mesh_terms: D001361:Avitaminosis; D005260:Female; D006801:Humans; D009751:Nutritional Requirements; D011247:Pregnancy; D014815:Vitamins / Q000009:adverse effects
chemical_list: D014815:Vitamins