Degree of neuronal activation following FG-7142 changes across regions during development.
We report that FG-7142 (20 mg/kg) differentially increased c-fos in the prefrontal cortex, nucleus accumbens, and striatum of rats 10, 18, 45, and 100 days of age. FG-7142 selectively activated the cortex in adults (70.7+/-3.0%), but the pattern was stronger in nucleus accumbens (83.4+/-9.8%) in younger subjects. These results are consistent with the delayed maturation of the cortex, and show that stress produces more diffuse effects early in life.
Lyss
P J
PJ
McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA.
Andersen
S L
SL
LeBlanc
C J
CJ
Teicher
M H
MH
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000254:growth & development; D002243:Carbolines / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects; D017397:Prefrontal Cortex / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002243:Carbolines; D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; C035874:FG 7142