alpha-Alkyl-alpha-Amino-beta-Lactam Peptides: Design, Synthesis, and Conformational Features.
Remarkable asymmetric induction is achieved in the alkylation of the lithium enolate of the beta-lactam 1. This allows the first time access to a new family of peptidomimetics 2 with predictable conformational constraints.
Palomo
C
Departamento de Química Orgánica, Universidad del País Vasco, Facultad de Química Apdo 1072, E-20080 San Sebastián (Spain).
Aizpurua
JM
Benito
A
Galarza
R
Khamrai
UK
Vazquez
J
de Pascual-Teresa B
Nieto
PM
Linden
A