Oxygen-independent microbicidal mechanisms of phagocytes.
The principal biological function of phagocytic cells is the destruction of invading microorganisms. Following phagocytosis, microbes are exposed to multiple antimicrobial substances ranging in complexity from simple oxygen radicals to large proteins. These substances disrupt various microbial structures and eventually kill and digest most of the invaders. This review is focused on oxygen-independent microbicidal mechanisms in granulocytes and macrophages.
Ganz
T
T
Department of Medicine, UCLA School of Medicine 90095-1690, USA.
D000486:Allergy and Immunology / Q000266:history; D000818:Animals; D001770:Blood Bactericidal Activity; D030342:Genetic Diseases, Inborn / Q000276:immunology / Q000378:metabolism; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D049673:History, 20th Century; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D010100:Oxygen / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D010587:Phagocytosis; D011506:Proteins / Q000378:metabolism; D014617:Vacuoles / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
D011506:Proteins; D010100:Oxygen