The effect of essentiale on histones and nucleic acids in liver and blood-forming tissues of rats irradiated with gamma-rays.
In this paper, the influence of the hepatoprotective drug Essentiale on the target (normal and regenerating liver) and the non-target (spleen and bone marrow) rat tissues was studied after whole body irradiation with the dose of 5.7 Gy gamma-radiation. The application of the drug 24 h before irradiation alleviated all the radiation induced changes of the histones and nucleic acids in the normal and regenerating liver tissue. In the non-target tissues only mild radioprotective effect was observed. The application of the preparation 30 min after irradiation was less effective than the application before irradiation. The repeated application of Essentiale after irradiation did not increase the beneficial effect of the previous preparation application.
Kozurková
M
M
P.J. Safárik University, Kosice, Slovakia. KOZURKO@LCS.Sk
Misúrová
E
E
Kropácová
K
K
Haková
H
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004247:DNA / Q000032:analysis*; D003627:Data Interpretation, Statistical; D004591:Electrophoresis, Polyacrylamide Gel; D005720:Gamma Rays; D006657:Histones / Q000032:analysis*; D008099:Liver / Q000187:drug effects / Q000528:radiation effects*; D008115:Liver Regeneration; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D012313:RNA / Q000032:analysis*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects*
D000276:Adjuvants, Immunologic; D003037:Cobalt Radioisotopes; D006657:Histones; D010713:Phosphatidylcholines; D011837:Radiation-Protective Agents; C011246:essential 303 forte; D012313:RNA; D004247:DNA