Hypothesis: more mutations to cure cancer?
Cancer results from the accumulation of selected mutations. We propose here that some combinations of mutations may be counterselected. To illustrate this, we show an analysis of allelotyping in human breast tumors in which we demonstrate that specific associations of genetic events are statistically under-represented. This emerging concept could be used in a new therapeutical approach of cancer.
Eisinger
F
F
Departement d'Oncogenetique, E9939 Inserm, Institut Paoli-Calmettes, Marseille, France.
Sobol
H
H
Birnbaum
D
D
D001943:Breast Neoplasms / Q000235:genetics* / Q000628:therapy*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D009154:Mutation