Long-term hemodynamic responses to vasodilator therapy in patients with severe left ventricular dysfunction.
Maximal oral vasodilator therapy resulted in long-term reduction of initially elevated pulmonary vascular resistance in 10 of 13 patients with severe heart failure who tolerated inotrope-supported uptitration of afterload reduction. Eleven patients were unable to tolerate vasodilator therapy and required inotropic support for successful cardiac transplantation.
Mills
R M
RM
Department of Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA.
Cunningham
M S
MS
D000704:Analysis of Variance; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D016027:Heart Transplantation; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000627:therapeutic use*; D011652:Pulmonary Circulation / Q000187:drug effects*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000503:physiopathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents; D020105:Milrinone