Alternative splicing of the Drosophila PTEN gene.
Mutations in the human PTEN gene have been identified in a number of different tumour types, and in the hamartomatous polyposis syndromes Cowden disease and Bannayan-Zonana syndrome. The PTEN gene encodes a phosphatase that antagonises phosphoinositide 3-kinase (PI3K) signalling by removing the 3' phosphate from phosphatidylinositol 3, 4,5-trisphosphate (PtdIns (3,4,5)P(3)). Here we show that the PTEN gene is conserved in the invertebrate Drosophila melanogaster and demonstrate that the gene undergoes alternative splicing.
Smith
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Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London, UK.
Smith
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Alrubaie
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Coehlo
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Leevers
S J
SJ
Ashworth
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D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D019143:Evolution, Molecular; D017344:Genes, Insect; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D016415:Sequence Alignment; D025521:Tumor Suppressor Proteins
D025521:Tumor Suppressor Proteins; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human