title: Environmental modulation of amphetamine-induced c-fos expression in D1 versus D2 striatal neurons.
abstract: We have reported previously that exposure to environmental novelty enhances the behavioral activating effects of amphetamine and its ability to induce the immediate early gene c-fos in the striatum and in other brain regions. In the present study, we used double in situ hybridization histochemistry to study the effect of amphetamine and/or novelty on c-fos expression in two populations of striatal neurons that preferentially express either D1 or D2 dopamine receptor mRNA. When given intraperitoneally to rats in their home cage, amphetamine (2.0 mg/kg) increased c-fos expression only in D1 neurons. In contrast, when the same dose of amphetamine was administered to rats in a novel environment, c-fos was increased in both D1 and D2 neurons. We conclude that the neural populations engaged by amphetamine vary as a function of the circumstances surrounding its administration.
authors.affiliation: Biopsychology, Department of Psychology, The University of Michigan, Ann Arbor 48109-1109, USA. alducci@umich.edu
authors.forename: A
authors.initials: A
authors.lastname: Badiani
authors.forename: M M
authors.initials: MM
authors.lastname: Oates
authors.forename: H E
authors.initials: HE
authors.lastname: Day
authors.forename: S J
authors.initials: SJ
authors.lastname: Watson
authors.forename: H
authors.initials: H
authors.lastname: Akil
authors.forename: T E
authors.initials: TE
authors.lastname: Robinson
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004777:Environment; D015870:Gene Expression / Q000187:drug effects*; D016762:Genes, fos / Q000187:drug effects*; D017403:In Situ Hybridization; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D018765:Dopamine Uptake Inhibitors; D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013565:Sympatholytics; D016627:Oxidopamine; D000661:Amphetamine