title: An in vivo evaluation of the effects of local magnetic susceptibility-induced gradients on water diffusion measurements in human brain.
abstract: The effect of possible susceptibility-induced gradients on measurements of water diffusion along the transverse and longitudinal axes of white matter fibers in the brain was investigated in vivo at 1.5 T. Measurements obtained with sequences sensitive and insensitive, respectively, to susceptibility-induced gradients indicated that these gradients do not contribute significantly to diffusion anisotropy in brain white matter. Furthermore, diffusion measurements were unaffected by the presence of known susceptibility-induced gradients at the interface between the petrous bone and brain parenchyma. These results agree with those obtained on in vitro samples and appear to support the hypothesis that interactions between the diffusing water molecules and the cellular environment constitute the principal mechanism for diffusion anisotropy in brain white matter at 1.5 T. This, in turn, simplifies the interpretation of diffusion time-dependent measurements in terms of membrane separation and permeability.
authors.affiliation: Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom.
authors.forename: C A
authors.initials: CA
authors.lastname: Clark
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
authors.forename: P S
authors.initials: PS
authors.lastname: Tofts
mesh_terms: D000465:Algorithms; D001834:Body Water / Q000737:chemistry*; D001923:Brain Chemistry; D003337:Corpus Callosum / Q000033:anatomy & histology; D004058:Diffusion; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019685:Rosales; D012886:Skull / Q000033:anatomy & histology