title: [Surgical treatment of N2 involved non-small cell lung cancer--the systematic extended lymph node dissection based on the regional lymphatic drainage].
abstract: From the study on regional lymphtic drainage, we have decided the extent of lymphadenectomy as follows; a) For the left lung cancer and the right upper lobe primary, systematic bilateral mediastinal dissection (R3 alpha) through a median sternotomy, b) For the cases with the highest mediastinal node involvement, lower half of radical neck dissection (R3 gamma) through a cervical collar incision in addition to a). The cN diagnosis by CT interpretation and pN diagnosis were compared. The under estimated rates of N were 32% of 137 patients with the left lung primary. 46 patients with pN2(+) included 14 patients (31%) with pN3 disease. As for the right upper lobe primary, 17 patients with pN2(+) included 13 patients (76%) with pN3 disease. Postoperative survival rates calculated with Kaplan-Meiermethod; 1) The five-year survival rates were 43% of 46 patients with pT1-3 N2-3 of the left lung primary. 2) As for the right upper lobe primary, the two-year survival rates were 51% of 17 patients with pT1-4 N2-3. 3) The three-year survival rates of 26 patients with pN3 gamma diagnosed as cN0-3 alpha preoperatively were 41%. These systematic extended dissection (R3 alpha, R3 gamma) would bring better prognosis in the patients with pN2-3 disease.
authors.affiliation: Surgical Department of Respiratory Center, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
authors.forename: R
authors.initials: R
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: N
authors.initials: N
authors.lastname: Katsuragi
authors.forename: T
authors.initials: T
authors.lastname: Kori
authors.forename: M
authors.initials: M
authors.lastname: Yanada
authors.forename: E
authors.initials: E
authors.lastname: Hata
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000601:surgery*; D008196:Lymph / Q000502:physiology*; D008197:Lymph Node Excision / Q000379:methods*; D008482:Mediastinum; D011379:Prognosis; D015996:Survival Rate