B cell non-Hodgkin's lymphoma in a girl with the DiGeorge anomaly.
The DiGeorge anomaly (DGA) is occasionally associated with cellular immunodeficiency. We report a female infant diagnosed with complete DGA, who developed fatal, high grade, non-Hodgkin's lymphoma that expressed Epstein-Barr virus (EBV). Non-Hodgkin's lymphoma should be considered in children with DGA.
Ramos
J T
JT
Division of Immunodeficiencies, Department of Pediatrics, Hospital 12 de Octubre, Cra. Andalucia Km 5,400 28041 Madrid, Spain. jramos@h12o.es
López-Laso
E
E
Ruiz-Contreras
J
J
Giancaspro
E
E
Madero
S
S
D004062:DiGeorge Syndrome / Q000150:complications*; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D016393:Lymphoma, B-Cell / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*