title: CT assessment of cerebral perfusion: experimental validation and initial clinical experience.
abstract: OBJECTIVE
  To validate a dynamic single-section computed tomographic (CT) method to measure cerebral blood volume (CBV) and cerebral blood flow (CBF) by using a noncarotid artery as the input and to demonstrate the feasibility of this method in a pilot series of patients.
  
  
  METHODS
  Twelve dynamic contrast material-enhanced CT studies were performed in beagles. CBV, CBF, and mean transit time (MTT) values were calculated by using an internal carotid artery (ICA) and a noncarotid artery as the input artery to the brain. Patient studies with use of the radial artery as the input were performed (a) repetitively in two patients after subarachnoid hemorrhage, (b) in a patient with a symptomatic ICA occlusion before and after the intravenous injection of 1 g of acetazolamide, and (c) in a patient with a malignant brain tumor.
  
  
  RESULTS
  Linear regression analyses revealed highly significant correlations (P < .001) between CBV (r, 0.98; slope, 0.96), CBF (r, 0.89; slope, 0.87), and MTT (r, 0.80; slope, 0.76) values calculated with the ICA and the noncarotid inputs. The CT-derived patient data correlated well with ancillary clinical and neuroradiologic findings.
  
  
  CONCLUSIONS
  Dynamic single-section CT scanning to measure CBV and CBF on the basis of a noncarotid input is a highly accessible and cost-effective blood flow measurement technique.
authors.affiliation: Imaging Research Laboratories, John P Robarts Research Institute, London, Ontario, Canada.
authors.forename: D G
authors.initials: DG
authors.lastname: Nabavi
authors.forename: A
authors.initials: A
authors.lastname: Cenic
authors.forename: R A
authors.initials: RA
authors.lastname: Craen
authors.forename: A W
authors.initials: AW
authors.lastname: Gelb
authors.forename: J D
authors.initials: JD
authors.lastname: Bennett
authors.forename: R
authors.initials: R
authors.lastname: Kozak
authors.forename: T Y
authors.initials: TY
authors.lastname: Lee
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001810:Blood Volume; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D004285:Dogs; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017534:Radial Artery; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000503:physiopathology; D014057:Tomography, X-Ray Computed