title: Research on complementary and alternative therapies for cancer: issues and methodological considerations.
abstract: Recent evidence suggests that at least one cancer patient in three uses some form of complementary and alternative medicine (CAM). We conducted a review of the published research on the efficacy of these treatments for breast cancer, which resulted in some observations about the current state of research and guidelines for future research. Although many of the papers reported encouraging results, the preponderance of phase I and II trials and other limitations precluded definitive conclusions about the efficacy of the treatments reported in these studies. A growing institutional base in this country has begun to facilitate improved research on CAM for cancer, yet many gaps remain. For example, there are no published reports of clinical trials or observational studies with survival endpoints for treatment agents used by many cancer patients. Clinical trials of a few CAM treatments are now in progress, but the results will not be available for several years. More complex and customized treatments may require innovative study designs and practitioner-investigator collaborations. Given the mounting evidence that CAM treatments are biologically active as well as widely used, CAM research may affect cancer outcomes.
authors.affiliation: Herbert Irving Comprehensive Cancer Center, Columbia University, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Jacobson
authors.forename: S B
authors.initials: SB
authors.lastname: Workman
authors.forename: F
authors.initials: F
authors.lastname: Kronenberg
mesh_terms: D001943:Breast Neoplasms / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000639:trends*; D000529:Complementary Therapies; D005260:Female; D006801:Humans; D019338:Polypharmacy; D012106:Research / Q000639:trends*