Effect of upregulation of AMPA glutamate receptors on cerebral O(2) consumption and blood flow in rat.
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, in cerebral cortex, underwent upregulation (35% increase) following chronic blockade with a non-competitive AMPA receptor antagonist, GYKI 52466 (1-(aminophenyl)-4-methyl-7, 8-methylenedioxy-5H-2,3-benzodiazepine). Such upregulation did not alter basal cerebrocortical blood flow or O(2) consumption. There was a much higher increase in blood flow and O(2) consumption in the upregulated, agonist (AMPA) stimulated cortices of anesthetized rats.
Sinha
A K
AK
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA.
Mirza
A H
AH
Liu
X
X
Chi
O Z
OZ
Weiss
H R
HR
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001569:Benzodiazepines; D001784:Blood Gas Analysis; D001923:Brain Chemistry / Q000235:genetics*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000235:genetics* / Q000502:physiology; D011149:Pons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics*
D014151:Anti-Anxiety Agents; D018091:Receptors, AMPA; C061950:GYKI 52466; D001569:Benzodiazepines