title: Locally recurrent malignant fibrous histiocytoma: a rare and aggressive genitourinary malignancy.
abstract: OBJECTIVE
  In this study, 22 cases of locally recurrent urological malignant fibrous histiocytoma were reviewed considering therapeutic options, follow-up and prognosis.
  
  
  METHODS
  In the available literature on this topic we identified 19 cases of locally recurrent genitourinary malignant fibrous histiocytoma. Three additional cases are discussed, primarily arising from the kidney, the bladder and the paratesticular region.
  
  
  RESULTS
  The prognosis of locally recurrent urological malignant fibrous histiocytoma was found to be extraordinarily poor. Only 2 of 22 patients have survived for longer than 3.5 years. One of them reported herein is still alive 10 years after extensive lymphatic spread accompanying the first local recurrence. In this case, late local recurrence occurred after an 8-year interval free of disease.
  
  
  CONCLUSIONS
  Malignant fibrous histiocytoma is an unusual urological malignancy with a high rate of local recurrence. The latter is frequently accompanied by metastatic disease and unrelenting progression. Despite the poor prognosis early detection of local failure and aggressive salvage therapy might offer the chance of long-term survival in selected cases. Close and life-long follow-up is advisable for patients once treated for recurrent urological malignant fibrous histiocytoma.
authors.affiliation: Department of Urology, University Clinic 'Carl Gustav Carus', Technical University of Dresden, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Froehner
authors.forename: A
authors.initials: A
authors.lastname: Manseck
authors.forename: M
authors.initials: M
authors.lastname: Haase
authors.forename: O W
authors.initials: OW
authors.lastname: Hakenberg
authors.forename: M P
authors.initials: MP
authors.lastname: Wirth
mesh_terms: D000368:Aged; D018219:Histiocytoma, Benign Fibrous / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D013997:Time Factors; D014565:Urogenital Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy