Myosin structure: does the tail wag the dog?
Previous crystal structures of the myosin head have shown two different conformations, postulated to be the beginning and the end of the actomyosin power stroke. A new crystal structure reveals a dramatically different conformation; but how does this conformation fit into the force-generating cycle of actomyosin interactions?
Cooke
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Department of Biochemistry & Biophysics, Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA. cooke@cgl.ucsf.edu
D000205:Actomyosin / Q000737:chemistry / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D008954:Models, Biological; D008958:Models, Molecular; D009119:Muscle Contraction / Q000502:physiology; D009218:Myosins / Q000737:chemistry* / Q000502:physiology; D011487:Protein Conformation
D000255:Adenosine Triphosphate; D000205:Actomyosin; D009218:Myosins