Evaluation of individual subjects in the analog classroom setting: II. Effects of dose of amphetamine (Adderall).
Multiple dependent variables were graphed for 29 subjects who participated in a double-blind evaluation of 4 doses of Adderall, plus positive (methylphenidate) and placebo control conditions. Five judges ranked the conditions for each subject, and analyses of individual subjects indicated that these rankings were concordant (reliable) across judges. Consensus rankings were assigned to each subject, and an analysis of these ranks showed that the conditions differed significantly. The choice of best conditions were judged to be across 3 doses of Adderall (10, 15, and 20 mg). This confirms the clinical impression of individual differences in optimal dose of stimulant medication. The methodological, graphical, and statistical methods presented in this article provide a systematic, reliable procedure for evaluating relative response of individuals to different doses of stimulant medication.
Wigal
S B
SB
University of California-Irvine 92612, USA.
Swanson
J M
JM
Greenhill
L
L
Waslick
B
B
Cantwell
D
D
Clevenger
W
W
Davies
M
M
Lerner
M
M
Regino
R
R
Fineberg
E
E
Baren
M
M
Browne
R
R
D000661:Amphetamine / Q000009:adverse effects / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D018592:Cross-Over Studies; D003626:Data Display; D004311:Double-Blind Method; D006801:Humans; D015588:Observer Variation; D012107:Research Design
D000697:Central Nervous System Stimulants; D000661:Amphetamine