[Diurnal triglyceride profiles in 30 young healthy men as a function of diet, fasting triglyceride levels, body composition and insulin sensitivity].
OBJECTIVE
To study predictors of diurnal capillary triglyceride (TG-c) profiles in healthy males.


METHODS
Observational, cross-sectional.


METHODS
University Hospital Utrecht, Department of Internal Medicine, the Netherlands.


METHODS
In 30 healthy males (20-34 years) TG-c was measured during three days, six times a day. Fasting blood was collected at inclusion. Body composition and HOMA ratio as insulin sensitivity index were determined. TG-c profiles were calculated as integrated area under the mean TG-c curve (TG-AUC).


RESULTS
All subjects had normal fasting plasma and capillary TG and cholesterol concentrations. Diurnal TG-c values were higher than fasting values. The average TG-AUC was 24.6 +/- 6.7 mmol/l over 14 hrs. Variables associated with TG-AUC were: fasting TG-c, relative fat mass, total protein and saturated fat intake. After correction for fasting TG-c only diet and fat mass were correlated with TG-AUC. The relative fat mass was positively correlated with the HOMA ratio and fasting insulin concentrations, suggesting that decreased insulin sensitivity accompanied increased body fat.


CONCLUSIONS
Triglyceride profiles provide information about the total diurnal TG load. The best determinant of diurnal triglyceride changes was fasting triglycerides. However, diet, body composition and insulin sensitivity are also important. Future investigations should address the question whether triglyceride profiles may be used to estimate more accurately the individual risk profile for coronary heart disease.
van Oostrom
A J
AJ
Academisch Ziekenhuis, Utrecht.
Castro Cabezas
M
M
Harmelink
M J
MJ
Twickler
T B
TB
Remijnse
T A
TA
Erkelens
D W
DW
D000328:Adult; D001823:Body Composition / Q000502:physiology*; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D004032:Diet / Q000639:trends; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009426:Netherlands; D012016:Reference Values; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides