Quasispecies of TT virus (TTV) with sequence divergence in hypervariable regions of the capsid protein in chronic TTV infection.
Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.
Nishizawa
T
T
Immunology Division, Jichi Medical School, Tochigi-Ken 329-0498, Tokyo 107-0062, Japan.
Okamoto
H
H
Tsuda
F
F
Aikawa
T
T
Sugai
Y
Y
Konishi
K
K
Akahane
Y
Y
Ukita
M
M
Tanaka
T
T
Miyakawa
Y
Y
Mayumi
M
M
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D002213:Capsid / Q000737:chemistry / Q000235:genetics; D002908:Chronic Disease; D004266:DNA Virus Infections / Q000821:virology*; D004267:DNA Viruses / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D006518:Hepatitis Viruses / Q000737:chemistry / Q000145:classification / Q000235:genetics*; D006525:Hepatitis, Viral, Human / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data
D004279:DNA, Viral