Clinical outcome in pneumococcal meningitis correlates with CSF lipoteichoic acid concentrations.
Lipoteichoic and teichoic acids are components of the cell wall of Streptococcus pneumoniae. A recently developed enzyme immunoassay was used in patients with pneumococcal meningitis to investigate lipoteichoic and teichoic acid concentrations in CSF at the first lumbar puncture in relation to the clinical outcome determined by the Glasgow Outcome Scale. Lipoteichoic and teichoic acid concentrations in CSF were significantly associated with neurologic sequelae and mortality in S. pneumoniae meningitis.
Schneider
O
O
Department of Neurology, University of Göttingen, Germany.
Michel
U
U
Zysk
G
G
Dubuis
O
O
Nau
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002675:Child, Preschool; D004185:Disability Evaluation; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D007223:Infant; D007231:Infant, Newborn; D008070:Lipopolysaccharides / Q000134:cerebrospinal fluid*; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid* / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D009994:Osmolar Concentration; D013129:Spinal Puncture; D013682:Teichoic Acids / Q000134:cerebrospinal fluid*
D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid