title: [Ednit influence on oxidation resistance of LDL lipoproteins in hypertensive subjects].
abstract: OBJECTIVE
  Evaluation of resistance of low density lipoproteins (LDLP) of the serum to oxidation in patients with essential hypertension (EH) before and after course treatment with ednit.
  
  
  METHODS
  10 patients with mild or moderate EH aged 38-58 years were given ednit for 1 or 2 months. 10 healthy males aged 35-48 years served control.
  
  
  RESULTS
  EH patients had high baseline levels of lipid peroxidation products in LDLP, while antioxidant resistance of LDPL was diminished by 67% (p < 0.05) compared to controls. Ednit treatment for 1 and 2 months enhanced this resistance in mild and moderate EH (p < 0.05).
  
  
  CONCLUSIONS
  Ednit raises resistance of LDLP to oxidation and as ACE inhibitor lowers arterial pressure. Therefore it can be used in EH.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Ragino
authors.forename: L D
authors.initials: LD
authors.lastname: Latyntseva
authors.forename: M V
authors.initials: MV
authors.lastname: Ivanova
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D008077:Lipoproteins, LDL; D004656:Enalapril