title: Blood pressure and risk of myocardial infarction in elderly men and women: the Rotterdam study.
abstract: OBJECTIVE
  To study the association between blood pressure and risk of myocardial infarction in elderly subjects.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  The Rotterdam Study, a Dutch population-based study.
  
  
  METHODS
  6004 men and women aged > or = 55 years.
  
  
  METHODS
  Fatal or non-fatal myocardial infarction (n = 190) during a 4-year follow-up.
  
  
  RESULTS
  After excluding participants using blood pressure-lowering medication and participants with a history of myocardial infarction, increasing levels of systolic blood pressure (SBP) were associated with increasing risk of first myocardial infarction (P for trend < 0.0001). The relative risk (RR) for an SBP of 160 mmHg or higher was 5.7 (95% confidence interval (CI) 1.9-17.1) compared with an SBP below 120 mmHg. Increasing diastolic blood pressure (DBP) was also associated with increasing risk of first myocardial infarction, with the RR reaching 2.5 (95% CI 1.4-4.5) in subjects with values of 80-90 mmHg compared with values below 70 mmHg (P for trend < 0.05). Analyses in subjects aged 70 years and over showed that the positive associations between SBP and DBP and risk of first myocardial infarction remained at older age.
  
  
  CONCLUSIONS
  These findings in a relatively healthy cohort of elderly subjects do not provide evidence for a J- or U-shaped relation between SBP and DBP and risk of first myocardial infarction. They suggest that the risk of first myocardial infarction increases with increasing level of systolic and diastolic blood pressure and that this relationship persists into older age.
authors.affiliation: Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: P C
authors.initials: PC
authors.lastname: van den Hoogen
authors.forename: N M
authors.initials: NM
authors.lastname: van Popele
authors.forename: E J
authors.initials: EJ
authors.lastname: Feskens
authors.forename: D A
authors.initials: DA
authors.lastname: van der Kuip
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J C
authors.initials: JC
authors.lastname: Witteman
mesh_terms: D000368:Aged; D001794:Blood Pressure; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D009426:Netherlands / Q000453:epidemiology; D012306:Risk