title: The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality.
abstract: We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17-2.13 and RR = 2.12; 95% CI = 1.11-4.05, respectively). Women with a family history seemed to be more susceptible to the detrimental effects of smoking; not to the effects of other risk factors. We found no effect modification by family history in men.
authors.affiliation: Department of Chronic Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Boer
authors.forename: E J
authors.initials: EJ
authors.lastname: Feskens
authors.forename: W M
authors.initials: WM
authors.lastname: Verschuren
authors.forename: J C
authors.initials: JC
authors.lastname: Seidell
authors.forename: D
authors.initials: D
authors.lastname: Kromhout
mesh_terms: D000328:Adult; D001835:Body Weight; D003327:Coronary Disease / Q000401:mortality*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D012907:Smoking