Methylphenidate effects on global and complex measures of EEG.
Methylphenidate (MPH) effects on global and complex measures of electroencephalography were examined in boys with attention-deficit-hyperactivity disorder between the ages of 9 and 11 years. Electroencephalogram (EEG) data were collected separately from the administration of a continuous performance task and were evaluated for changes in overall frequency, coherence, phase, and asymmetry and against a referential database. MPH did not produce a clear change in EEG frequency measures compared with the task condition, although it did induce regional changes in the EEG and produced an improvement in task performance. In comparison against the referential database, MPH appeared to lessen the impact of abnormalities in EEG coherence, EEG phase, and EEG asymmetry on performance measures.
Lubar
J F
JF
Department of Psychology, University of Tennessee, Knoxville 37996, USA.
White
J N
JN
Swartwood
M O
MO
Swartwood
J N
JN
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D018592:Cross-Over Studies; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects
D000697:Central Nervous System Stimulants; D018765:Dopamine Uptake Inhibitors; D008774:Methylphenidate