Growth hormone treatment during suppression of early puberty in adopted girls. Swedish Growth Hormone Advisory Group.
Girls adopted from developing countries often have early or precocious puberty, requiring treatment with gonadotropin-releasing hormone (GnRH) analogues. During such treatment decreased growth velocity is frequent. The aim of this investigation was to study whether the addition of growth hormone (GH) to GnRH analogue treatment improves height velocity and final height in girls with early or precocious puberty. Forty-six girls with early or precocious puberty adopted from developing countries were randomized for treatment with GnRH analogue or a combination of GH and GnRH analogue. After 2 y of treatment the mean growth in the GH/GnRH analogue group was significantly higher, 14.6 cm, compared to 10.9 cm in the control group. The increase in bone age did not differ, while the difference in predicted adult height increased by 2.7 cm in favour of the combination group. Although data on final height are not yet available, combined GH/GnRH analogue treatment for 2 y resulted in a higher growth velocity and predicted final height compared to GnRH analogue treatment alone.
Tuvemo
T
T
Department of Women's and Children's Health, Uppsala University Hospital, Sweden.
Gustafsson
J
J
Proos
L A
LA
D000300:Adoption; D001786:Blood Glucose / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D015992:Body Mass Index; D002648:Child; D003906:Developing Countries; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage* / Q000031:analogs & derivatives; D006062:Gonadotropins / Q000097:blood / Q000378:metabolism; D019382:Human Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011629:Puberty, Precocious / Q000188:drug therapy*; D013548:Sweden
D001786:Blood Glucose; D006062:Gonadotropins; D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone