Changes in spine and radius bone density during long-term hormone replacement.
Lumbar spine and mid-radius bone mineral density was measured repeatedly in 48 postmenopausal women who completed 7 years of taking either a 500 mg x day(-1) calcium supplement (n = 22) or calcium supplementation with hormone replacement therapy. The hormone replacement was either a low dose (n = 15) or a moderate dose (n = regime. The purpose of the measurements was to establish the long-term pattern of change in bone mineral mass produced by continued hormone replacement. The calcium-only group lost bone mineral mass at the radius, while the spine, bone was preserved. Low dose hormone replacement preserved radius bone. Moderate dose replacement increased bone mineral mass at the spine and preserved radius bone.
Blake
J M
JM
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, Canada.
Ryan
E D
ED
Beaumont
L F
LF
Webber
C E
CE
D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011446:Prospective Studies; D011884:Radius / Q000187:drug effects*; D015203:Reproducibility of Results; D013131:Spine / Q000187:drug effects*
D015675:Osteocalcin; D002118:Calcium