Unilateral testicular torsion: protective effect of verapamil on contralateral testicular histology.
In this experimental study, it was our aim to reduce the effects of ischemic insults to the contralateral testicle after unilateral testicular torsion. The protective effect of a calcium channel blocking agent (verapamil) on the histology and the tubular diameter of contralateral testicle was evaluated. Following a definite period of unilateral testicular torsion (i.e., 4 h), the protective effect of this specific medication was evaluated both after detorsion and orchiectomy procedures. The results of our study demonstrated the protective effect of verapamil on both parameters, especially in animals undergoing orchiectomy. The majority of the specimens demonstrated normal histologic findings together with preserved tubular structures after a 1-week period under verapamil medication.
Sarica
K
K
Department of Urology, Sahinbey Hospital, University of Gaziantep Medical School, Gaziantep, Turkey.
Bakir
K
K
Yagci
F
F
Erbagci
A
A
Topcu
O
O
Uysal
O
O
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy; D051381:Rats; D017208:Rats, Wistar; D013086:Spermatic Cord Torsion / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D013737:Testis / Q000098:blood supply / Q000473:pathology*; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014700:Verapamil