title: Human platelet alloantigen (HPA)-5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation.
abstract: Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectively investigated in 715 unrelated bone marrow transplantations. Of the five HPA systems studied, HPA-5 mismatching was found to have a significant effect on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The effect of the HPA-5 mismatch was most significant in the recipient group possessing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotype among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching decreases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.
authors.affiliation: Japanese Red Cross Central Blood Center, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Juji
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Tonami
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Satake
authors.forename: T
authors.initials: T
authors.lastname: Akaza
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
authors.forename: Y
authors.initials: Y
authors.lastname: Kodera
authors.forename: T
authors.initials: T
authors.lastname: Sasazuki
authors.forename: Y
authors.initials: Y
authors.lastname: Morishima
authors.forename: F
authors.initials: F
authors.lastname: Takaku
mesh_terms: D016824:Antigens, Human Platelet / Q000235:genetics*; D016026:Bone Marrow Transplantation / Q000276:immunology* / Q000401:mortality; D018572:Disease-Free Survival; D000939:Epitopes / Q000235:genetics; D005838:Genotype; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000628:therapy; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: C071092:5a alloantigen, human; C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D000939:Epitopes; D015778:Minor Histocompatibility Antigens