title: Percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fractures: an open prospective study.
abstract: OBJECTIVE
  To assess the efficacy and safety of percutaneous vertebroplasty in osteoporotic vertebral compression fractures responsible for severe and persistent pain.
  
  
  METHODS
  Sixteen patients were included in this open prospective study. Inclusion criteria were: one or 2 vertebral fractures responsible for severe pain, i.e., higher than 50 mm on a visual analog scale (VAS: 0-100 mm), scores 3, 4 or 5 according to the McGill-Melzack scoring system, and evolving for more than 3 months. Assessment criteria were the changes over time (Days 3, 30, 90, 180) in VAS and McGill-Melzack scoring system. The changes over time in a generic health status instrument score [the Nottingham Health Profile (NHP)] were also assessed. Statistical comparisons were performed using the Wilcoxon T test.
  
  
  RESULTS
  There were 9 women and 7 men: postmenopausal osteoporosis (n = 7), corticosteroid induced osteoporosis (n = 2), and male osteoporosis (n = 7). Vertebroplasty was performed in 20 vertebrae. A statistically significant decrease of both VAS (-53%, p < 0.0005) and McGill-Melzack scoring system (p < 0.005) was observed at Day 3. The results were also significant at Days 30, 90, and 180 for both scales (p < 0.005 and p < 0.01, respectively). A significant decrease over time for 5/6 dimensions of the NHP score was also noted: pain (p < 0.01), physical mobility (p < 0.05), emotional reactions (p < 0.05), social isolation (p < 0.05), and energy (p < 0.05). We observed no adverse event, and no vertebral fracture has occurred after 6 months of followup.
  
  
  CONCLUSIONS
  Percutaneous vertebroplasty is a useful and safe procedure for treating persistent painful osteoporotic fractures. Controlled studies with longterm followup are required.
authors.affiliation: Department of Rheumatology, University Hospital of Lille, France. bcortet@chru-lille.fr
authors.forename: B
authors.initials: B
authors.lastname: Cortet
authors.forename: A
authors.initials: A
authors.lastname: Cotten
authors.forename: N
authors.initials: N
authors.lastname: Boutry
authors.forename: R M
authors.initials: RM
authors.lastname: Flipo
authors.forename: B
authors.initials: B
authors.lastname: Duquesnoy
authors.forename: P
authors.initials: P
authors.lastname: Chastanet
authors.forename: B
authors.initials: B
authors.lastname: Delcambre
mesh_terms: D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications* / Q000000981:diagnostic imaging; D017063:Outcome Assessment, Health Care; D019904:Polymethyl Methacrylate / Q000627:therapeutic use*; D011446:Prospective Studies; D011859:Radiography; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate