title: Moyamoya disease in Italian monozygotic twins.
abstract: We report white monozygotic twins with moyamoya disease (MMD) (adult ischemic type). Both had cerebral angiography, MRI, magnetic resonance angiography, SPECT, EEG, human leukocyte antigen (HLA) typing, evaluation of thrombophilia, and immunologic and karyotype analysis. The clinical features and HLA phenotypes described in Asian monozygotic twins with MMD were not found in our patients. However, genetic analysis revealed a homozygous state for C-->T (Ala-->Val substitution) in position 677 of the methylenetetrahydrofolate reductase-encoding gene.
authors.affiliation: Department of Neurology, Ospedale Cardarelli, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Andreone
authors.forename: A
authors.initials: A
authors.lastname: Ciarmiello
authors.forename: C
authors.initials: C
authors.lastname: Fusco
authors.forename: G
authors.initials: G
authors.lastname: Ambrosanio
authors.forename: C
authors.initials: C
authors.lastname: Florio
authors.forename: I
authors.initials: I
authors.lastname: Linfante
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007558:Italy; D008279:Magnetic Resonance Imaging; D009072:Moyamoya Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology