title: Low-cholesterol and high-fat diets reduce atherosclerotic lesion development in ApoE-knockout mice.
abstract: We have investigated the effect of most common oils used in human nutrition on the development of atherosclerosis in apoE-knockout mice. Seven groups of animals, separated according to sex, were fed for 10 weeks either chow diet or the chow diet 10% (wt/wt) enriched with different oils (palm, coconut, 2 types of olive oil, and 2 types of sunflower oil) without addition of cholesterol. At the end of this period, plasma lipid parameters were measured and vascular lesions scored. None of the diets induced changes in plasma cholesterol concentrations, whereas plasma triglycerides were uniformly reduced in all diet groups. Some diets caused significant reductions in the size of atherosclerotic lesions in males and others in females; males responded most to sunflower oils and females to palm oil and one olive oil (II). The lesion reduction in males consuming sunflower oils was associated with the decrease of triglycerides in triglyceride-rich lipoproteins, whereas the decrease in females consuming olive oil II or palm oil was accompanied by an increase in plasma apoA-I. The increase in plasma apoA-I in the latter condition, is mainly due to overexpression of hepatic message elicited by a mechanism independent of apoE ligand. The data suggest that the different diets modulate lesion development in a gender specific manner and by different mechanisms and that the development of atherosclerosis, due to genetic deficiencies, may be modulated by nutritional maneuvers that may be implemented in human nutrition.
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Calleja
authors.forename: M A
authors.initials: MA
authors.lastname: París
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.forename: E
authors.initials: E
authors.lastname: Vilella
authors.forename: J
authors.initials: J
authors.lastname: Joven
authors.forename: A
authors.initials: A
authors.lastname: Jiménez
authors.forename: G
authors.initials: G
authors.lastname: Beltrán
authors.forename: M
authors.initials: M
authors.lastname: Uceda
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Osada
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics*; D001161:Arteriosclerosis / Q000178:diet therapy* / Q000235:genetics; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000097:blood* / Q000494:pharmacology*; D000074263:Coconut Oil; D004036:Diet, Atherogenic; D005260:Female; D015870:Gene Expression / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000069463:Olive Oil; D000073878:Palm Oil; D010938:Plant Oils / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D012737:Sex Factors; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D002791:Cholesterol, Dietary; D000069463:Olive Oil; D010938:Plant Oils; D012333:RNA, Messenger; D000074242:Sunflower Oil; D014280:Triglycerides; D000073878:Palm Oil; D000074263:Coconut Oil