title: Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines.
abstract: Many of the latest trends in vaccine development are dependent on immunological adjuvants that mediate and promote a wide variety of immune responses. One promising adjuvant candidate, monophosphoryl lipid A (MPL) immunostimulant, is being investigated with many of these new vaccine approaches in either preclinical or clinical trials. This is possible because different vehicle formulations can significantly influence the type of immunological response MPL promotes. Procedures are provided for formulating MPL in an aqueous vehicle or an oil-in-water emulsion. These two MPL formulations can be beneficial for most vaccine approaches being investigated today.
authors.affiliation: Ribi ImmunoChem Research, Inc., 553 Old Corvallis Road, Hamilton, Montana 59840, USA. jrbald@ribi.com
authors.forename: J R
authors.initials: JR
authors.lastname: Baldridge
authors.forename: R T
authors.initials: RT
authors.lastname: Crane
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000302:isolation & purification; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D004339:Drug Compounding; D004655:Emulsions; D008050:Lipid A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification; D051379:Mice; D009821:Oils; D014612:Vaccines / Q000008:administration & dosage*; D014867:Water
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D004655:Emulsions; D008050:Lipid A; D009821:Oils; D014612:Vaccines; D014867:Water; C048436:monophosphoryl lipid A