Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1.
Non-invasive delivery of peptide and protein drugs will soon become a reality. This is due partly to a better understanding of the endogenous transport mechanisms, including paracellular transport, endocytosis, and carrier-mediated transport of mucosal routes of peptide and protein drug administration. This paper focuses on work related to the elucidation of structure-function, intracellular trafficking, and regulation of the intestinal dipeptide transporter, PepT1.
Lee
V H
VH
Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA. vincentL@hsc.usc.edu
Chu
C
C
Mahlin
E D
ED
Basu
S K
SK
Ann
D K
DK
Bolger
M B
MB
Haworth
I S
IS
Yeung
A K
AK
Wu
S K
SK
Hamm-Alvarez
S
S
Okamoto
C T
CT
D001692:Biological Transport; D001702:Biopharmaceutics; D002352:Carrier Proteins / Q000493:pharmacokinetics*; D004151:Dipeptides / Q000493:pharmacokinetics*; D009092:Mucous Membrane / Q000378:metabolism; D009842:Oligopeptides / Q000493:pharmacokinetics*; D000074011:Peptide Transporter 1; D011506:Proteins / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship; D027981:Symporters
D002352:Carrier Proteins; D004151:Dipeptides; D009842:Oligopeptides; D000074011:Peptide Transporter 1; D011506:Proteins; D027981:Symporters