Synthesis and biological evaluation of 2-methoxy- and 2-methylthio-6-[2'-alkylamino)ethyl]-4(3H)-pyrimidinones with anti-rubella virus activity.
The synthesis of a new family of antiviral compounds, 2-methoxy-, and 2-methylthio-6-[(2'-alkylamino)ethyl]-4(3H)-pyrimidinones, has been accomplished. The activity of these agents against positive strand (rubella virus and sindbis virus) and negative strand (vesicular stomatitis virus) RNA viruses is reported. Some of these compounds are efficient and selective inhibitors of rubella virus.
Botta
M
M
Dipartimento Farmaco Chimico Tecnologico, Banchi di Sotto 55, Universitá degli Studi, Siena, Italy. botta@unisi.it
Occhionero
F
F
Nicoletti
R
R
Mastromarino
P
P
Conti
C
C
Magrini
M
M
Saladino
R
R
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012412:Rubella virus / Q000187:drug effects* / Q000254:growth & development; D013057:Spectrum Analysis; D014709:Vero Cells; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D011744:Pyrimidinones