The ratio of interleukin-6 to interleukin-10 correlates with severity in patients with chest and abdominal trauma.
To evaluate the relation between proinflammatory cytokines and antiinflammatory cytokines after major trauma, we measured pro-inflammatory cytokine (interleukin [IL]-6) and antiinflammatory cytokine (IL-10) concentrations after trauma, and evaluated the relationship between the ratio of IL-6 to IL-10 and injury severity. In 20 patients who sustained chest and abdominal trauma, IL-10, IL-6, and lactate concentrations were measured at 0, 1, 2, and 4 days. The Injury Severity Score (ISS), Acute Physiology and Chronic Health Evaluation (APACHE) II score, and the ratio of IL-6 to IL-10 were calculated. IL-6, IL-10, and lactate concentrations were 197.2+/-28.4 (mean +/- SEM), 71.1+/-10.1 pg/mL, and 46.7+/-9.4 mg/dL at entry. These concentrations were significantly decreased at day 4. The ratio of IL-6 to IL-10 was 3.11+/-0.47 at entry and was significantly correlated with ISS (r=.872, P<.01), APACHE II score (r=.887, P<.01). The IL-10, IL-6, and lactate concentrations were elevated immediately after major trauma, and the ratio of IL-6 to IL-10 was correlated with injury severity. This suggests that the ratio of IL-6 to IL-10 may be used to predict the injury severity after trauma.
Taniguchi
T
T
Department of Emergency and Critical Care Medicine, Tama-nagayama Hospital, Nippon Medical School, Tokyo, Japan.
Koido
Y
Y
Aiboshi
J
J
Yamashita
T
T
Suzaki
S
S
Kurokawa
A
A
D018806:APACHE; D000007:Abdominal Injuries / Q000276:immunology*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D019344:Lactic Acid / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D013898:Thoracic Injuries / Q000276:immunology*; D015599:Trauma Severity Indices
D015415:Biomarkers; D015850:Interleukin-6; D016753:Interleukin-10; D019344:Lactic Acid