[Steroid receptors and mechanism of action of sex steroids].
Steroid hormone receptors define a large family of proteins. Recently, a new estradiol receptor has been identified. This discovery suggests the existence of a previously unrecognized pathway of estrogen signalling. Moreover, it implies important pharmacological consequences. Receptors activation induces the modulation of transcription of specific genes. Proteins involved in this effect have been identified: coactivators, corepressors and cointegrators. Their mechanism of action have been characterized. They modify histone acetylation of the corresponding promotor. Sex steroid receptors are located in the nucleus. This nuclear localization is in fact a dynamic situation, resulting from a continuous shuttling of the receptor between the cytoplasm and the nucleus. Non genomic effects of steroids have also been described.
Guiochon-Mantel
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INSERM U135, Laboratoire d'Hormonologie et Biologie Moléculaire, Hôpital Bicêtre, Le Kremlin Bicêtre.
Milgrom
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E
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology; D005786:Gene Expression Regulation; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D011401:Promoter Regions, Genetic; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D013256:Steroids / Q000502:physiology*; D014158:Transcription, Genetic
D012739:Gonadal Steroid Hormones; D011987:Receptors, Steroid; D013256:Steroids