Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome.
A 23 year old woman with idiopathic long QT syndrome had repeated syncopal attacks associated with torsades de pointes. T wave alternans (TWA) was recorded and the QT interval was abnormally prolonged during treadmill exercise test. Monophasic action potential (MAP) alternans also appeared after an abrupt shortening of the cycle length in electrophysiological study. After intravenous administration of nicorandil 6 mg, both TWA and MAP alternans disappeared.
Fujimoto
Y
Y
Department of Cardiovascular Medicine, Okayama University Medical School, 2-5-1 Shikata, Okayama 700-8558, Japan.
Morita
H
H
Fukushima
K K
KK
Ohe
T
T
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004562:Electrocardiography; D004594:Electrophysiology; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D020108:Nicorandil / Q000627:therapeutic use*; D013575:Syncope / Q000209:etiology / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D020108:Nicorandil