title: [Inhibin and ovarian cancer].
abstract: Previous observations from our laboratory have demonstrated that the levels of immunoreactive inhibin (ir-inh) are elevated in almost all patients with granulosa cell tumors and in the majority of postmenopausal women with mucinous ovarian cancers. The present report confirms these findings in a larger group of post-menopausal women. Immunohistochemistry for the inhibin alpha. beta A and beta B sununits shows predominantly epithelial staining in granulosa cell tumors and in the majority of mucinous cancers. Serous cystadenocarcinomas also frequently show positive staining. Studies seeking to identify G alpha i-2 or FSH receptor mutations have provided negative results in contrast to other reports. Further studies of the roles of the inhibin-related family of peptides in ovarian cancer diagnosis and monitoring are clearly indicated.
authors.affiliation: Prince Henry's Institute of Medical Research, Victoria, Australia.
authors.forename: H G
authors.initials: HG
authors.lastname: Burger
authors.forename: A
authors.initials: A
authors.lastname: Baillie
authors.forename: A E
authors.initials: AE
authors.lastname: Drummond
authors.forename: D L
authors.initials: DL
authors.lastname: Healy
authors.forename: T
authors.initials: T
authors.lastname: Jobling
authors.forename: P
authors.initials: P
authors.lastname: Mamers
authors.forename: D M
authors.initials: DM
authors.lastname: Robertson
authors.forename: B
authors.initials: B
authors.lastname: Susil
authors.forename: N
authors.initials: N
authors.lastname: Cahir
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: K
authors.initials: K
authors.lastname: Verity
authors.forename: P J
authors.initials: PJ
authors.lastname: Fuller
authors.forename: N P
authors.initials: NP
authors.lastname: Groome
authors.forename: J K
authors.initials: JK
authors.lastname: Findlay
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000097:blood; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018284:Cystadenocarcinoma, Serous / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000097:blood*; D008875:Middle Aged; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010051:Ovarian Neoplasms / Q000097:blood* / Q000235:genetics; D017698:Postmenopause; D011962:Receptors, FSH / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C029152:G-substrate; D009419:Nerve Tissue Proteins; D011962:Receptors, FSH; D007265:Inhibins