Effect of methamphetamine on male mice fertility.
The effect of methamphetamine (MAMP) on the ability of males to mate with females and to impregnate them was examined in 8-week-old ICR mice. Male mice that had been administered an intraperitoneal injection of MAMP (15 mg/kg, 7.5 mg/kg, or 3.75 mg/kg) or saline were housed with females 24 or 48 hours later. The vaginal plugs were checked, and the number of births was counted. The effect of MAMP on sperm motility and the serum testosterone (TS) concentration was also examined. Methamphetamine was observed to have harmful effects only at the highest dose level. In the mice housed 24 hours after the injection of 15 mg/kg MAMP, the increase in the cumulative number of vaginal plugs lagged, and the total number of vaginal plugs decreased significantly. A significant decrease was also observed in the total number of births. Methamphetamine, at a dose of 15 mg/kg, decreased sperm motility. The TS concentration decreased initially, then increased.
Yamamoto
Y
Y
Department of Legal Medicine, Kyoto University Faculty of Medicine, Japan.
Yamamoto
K
K
Hayase
T
T
D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004822:Epididymis / Q000033:anatomy & histology; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005306:Fertilization; D007700:Kinetics; D008297:Male; D008694:Methamphetamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011256:Pregnancy Outcome; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood; D014621:Vagina / Q000033:anatomy & histology
D000697:Central Nervous System Stimulants; D013739:Testosterone; D008694:Methamphetamine