title: Predicting protein structure using only sequence information.
abstract: This paper presents results of blind predictions submitted to the CASP3 protein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model-based method for constructing protein family profiles. The method is purely sequence-based, using no structural information, and yet was able to predict structures as well as all but five of the structure-based methods in CASP3.
authors.affiliation: John Baskin School of Engineering, University of California, Santa Cruz 95064, USA. karplus@cse.ucsc.edu
authors.forename: K
authors.initials: K
authors.lastname: Karplus
authors.forename: C
authors.initials: C
authors.lastname: Barrett
authors.forename: M
authors.initials: M
authors.lastname: Cline
authors.forename: M
authors.initials: M
authors.lastname: Diekhans
authors.forename: L
authors.initials: L
authors.lastname: Grate
authors.forename: R
authors.initials: R
authors.lastname: Hughey
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D008390:Markov Chains; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
chemical_list: D011506:Proteins