title: Fibro-osseous lesions of the central nervous system: report of four cases and literature review.
abstract: Fibro-osseous lesions, also reported as calcifying pseudoneoplasms of the neural axis, are uncommon lesions of the CNS. We report four additional cases: two extraaxial and two intraaxial, in patients ages 33, 47, 49, and 59 years at presentation. Fibro-osseous lesions involving the CNS demonstrate variable proportions of fibrous stroma, bone, palisading spindle to epithelioid to multinucleated cells in association with a highly distinctive, perhaps pathognomonic, chondromyxoid-like matrix often distributed in a nodular pattern. This histopathologically distinctive lesion can be seen in many regions of the neuraxis, often with a dural association, and most commonly along the vertebral column. It appears to be a slow-growing lesion and, with wide excision, the prognosis is excellent. The etiology remains unclear, but the preponderance of data favors a reactive rather than neoplastic process. If this putative pseudotumor is not recognized histopathologically, a neoplastic or infectious differential might result in inappropriate investigations and potentially harmful therapies.
authors.affiliation: Department of Pathology, Strong Memorial Hospital, University of Rochester, New York 14642, USA.
authors.forename: J
authors.initials: J
authors.lastname: Qian
authors.forename: A
authors.initials: A
authors.lastname: Rubio
authors.forename: J M
authors.initials: JM
authors.lastname: Powers
authors.forename: M K
authors.initials: MK
authors.lastname: Rosenblum
authors.forename: W H
authors.initials: WH
authors.lastname: Pilcher
authors.forename: D A
authors.initials: DA
authors.lastname: Shrier
authors.forename: B M
authors.initials: BM
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Iannucci
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002356:Cartilage / Q000473:pathology; D002493:Central Nervous System Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006099:Granuloma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor