title: Evidence for oxidant stress in chronic pancreatitis.
abstract: BACKGROUND
  Oxidant stress leading to lipid peroxidation is reported to be the common link in the pathogenesis of chronic pancreatitis irrespective of etiology.
  
  
  OBJECTIVE
  To look for evidence of lipid peroxidation in duodenal juice in patients with chronic pancreatitis.
  
  
  METHODS
  19 patients with chronic pancreatitis (14 tropical, 5 alcoholic) and 19 age- and sex-matched subjects with abdominal pain without any cause were studied. Contents were aspirated from the second part of the duodenum during gastroduodenoscopy. Malonyl dialdehyde (MDA) levels were measured in duodenal juice by the thiobarbituric acid method.
  
  
  RESULTS
  MDA levels were higher in patients than in the control group (mean [SD] 42.6 [17.0] vs 29.2 [11.7] nmol/mL; p < 0.05). On linear and multiple regression analysis, none of the disease factors correlated with duodenal juice MDA levels.
  
  
  CONCLUSIONS
  Lipid peroxidation products are increased in patients with chronic tropical and alcoholic pancreatitis.
authors.affiliation: Gastroenterology Unit, Kasturba Medical College, Manipal.
authors.forename: C
authors.initials: C
authors.lastname: Ganesh Pai
authors.lastname: Sreejayan
authors.forename: M N
authors.initials: MN
authors.lastname: Rao
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004386:Duodenum / Q000378:metabolism; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000737:chemistry; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010195:Pancreatitis / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde