title: Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein.
abstract: Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11.
authors.affiliation: Departments of Medicine and Biochemistry, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. dcohen@aecom.yu.edu
authors.forename: D E
authors.initials: DE
authors.lastname: Cohen
authors.forename: R M
authors.initials: RM
authors.lastname: Green
authors.forename: M K
authors.initials: MK
authors.lastname: Wu
authors.forename: D R
authors.initials: DR
authors.lastname: Beier
mesh_terms: D000595:Amino Acid Sequence; D000727:Androgen-Binding Protein; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D009928:Organ Specificity; D049488:Phosphatidylethanolamine Binding Protein; D049294:Phospholipid Transfer Proteins
chemical_list: D000727:Androgen-Binding Protein; D002352:Carrier Proteins; D018076:DNA, Complementary; C511482:PEBP1 protein, human; D049488:Phosphatidylethanolamine Binding Protein; D049294:Phospholipid Transfer Proteins