title: A Novel Dinuclear Diaminoplatinum(II) Glutathione Macrochelate.
abstract: Both oxidized and reduced glutathione (gamma-L-Glu-L-Cys-Gly) react with the anticancer complex [Pt(en)Cl(2)] to form the bicyclic complex illustrated (en=ethylenediamine). This unprecedented structure, which was determined from extensive NMR experiments, contains a ten-membered macrochelate ring.
authors.affiliation: Department of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ (UK).
authors.lastname: del Socorro Murdoch P
authors.initials: NA
authors.lastname: Kratochwil
authors.initials: JA
authors.lastname: Parkinson
authors.initials: M
authors.lastname: Patriarca
authors.initials: PJ
authors.lastname: Sadler