Synthesis and antiprotozoan properties of new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives.
In a search for antiprotozoan compounds, 34 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan activity. In vivo assays of compounds which showed remarkable in vitro activity against T. vaginalis were carried out.
Ochoa
C
C
Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Pérez
E
E
Pérez
R
R
Suárez
M
M
Ochoa
E
E
Rodríguez
H
H
Gómez Barrio
A
A
Muelas
S
S
Nogal
J J
JJ
Martínez
R A
RA
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000994:Antitrichomonal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D051379:Mice; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014247:Trichomonas Vaginitis / Q000188:drug therapy / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D013829:Thiadiazines