Generalized eruptive histiocytoma of childhood associated with rheumatic fever.
We describe a widespread papular eruption in a 5-year-old girl with rheumatic fever. Histological examination revealed a dense histiocytic infiltration in the dermis. On immunohistochemical studies, the cells were positive for vimentin, CD68, MAC387, alpha1-antichymotrypsin and lysozyme, but negative for CD1a and S-100 protein. Electron microscopic studies showed no Birbeck granules in their cytoplasm. A diagnosis of generalized eruptive histiocytoma of childhood was established. The skin lesions completely disappeared within 8 months.
Matsushima
Y
Y
Department of Dermatology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. ymatsush@sb.gunma-u.ac.jp
Ohnishi
K
K
Ishikawa
O
O
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D002675:Child, Preschool; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009113:Muramidase / Q000032:analysis; D012213:Rheumatic Fever / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D009113:Muramidase; D000514:alpha 1-Antichymotrypsin; C067980:CD68 antigen, human; D000097382:CD68 Molecule