title: Effect of truncal vagotomy on gallbladder bile kinetics in conscious dogs.
abstract: Previous studies on the effects of vagotomy on gallbladder (GB) motility have yielded conflicting results. The aim of this study was to evaluate the effects of vagotomy on GB motility and bile kinetics using a new method. Twelve dogs were divided into two groups of six (control and pyloroplasty) and, 4 weeks later, underwent truncal vagotomy. A catheter secured in the GB fundus was used to monitor GB volume. After injecting polyethylene glycol (PEG) into the GB, combined measurements of GB volume and PEG concentration enabled GB emptying and bile kinetics to be estimated. Seven and five of the 12 vagotomized dogs were classified as having large and normal fasting GB volumes, respectively. Postprandial GB emptying was impaired when the fasting GB volume was enlarged. In the fasting state, bile kinetics of vagotomized dogs were significantly smaller than the control values. The emptying ability of the GB of vagotomized dogs with large fasting GB volumes was reduced considerably both in the postprandial and the fasting states. Such retention of bile in the GB after vagotomy may facilitate cholesterol crystal nucleation and stone growth.
authors.affiliation: Gastrointestinal Research Laboratory, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan. smuramat@akagi.sb.gunma-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Muramatsu
authors.forename: K
authors.initials: K
authors.lastname: Sonobe
authors.forename: K
authors.initials: K
authors.lastname: Tohara
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Mizumoto
authors.forename: R
authors.initials: R
authors.lastname: Ibuki
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Z
authors.initials: Z
authors.lastname: Itoh
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D003243:Consciousness; D004285:Dogs; D005215:Fasting; D005704:Gallbladder / Q000294:innervation* / Q000378:metabolism*; D016473:Gallbladder Emptying / Q000502:physiology*; D007700:Kinetics; D019518:Postprandial Period; D011708:Pylorus / Q000601:surgery; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology / Q000601:surgery