The marked inhibition of the bitter taste of Polymyxin B sulfate and trimethoprim x sulfamethoxazole by flavored BMI-60 in pediatric patients.
Taste acceptability of ground Polymyxin B sulfate and Bactramin C tablets was examined when flavored BMI-60, a food additive, was added. Both adult and child volunteers found the bitter taste of the two drugs markedly inhibited, making it clinically useful. Noncompliance, due to this bitterness, was improved using flavored BMI-60. The most striking characteristic of flavored BMI-60 is the ease of preparation compared with the manufacture of other hospital pharmaceuticals such as jelly, gummi and candy done to mask bitterness.
Saito
M
M
Pharmacy, Fukushima Medical University Hospital, Japan.
Hoshi
M
M
Igarashi
A
A
Ogata
H
H
Edo
K
K
D000328:Adult; D000890:Anti-Infective Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D005421:Flavoring Agents / Q000494:pharmacology*; D006801:Humans; D011112:Polymyxin B / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D000890:Anti-Infective Agents; D005421:Flavoring Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011112:Polymyxin B