Secretory proteins of Mycobacterium habana induce a protective immune response against experimental tuberculosis.
The capacity of proteins of Mycobacterium habana TMC 5135 secreted into culture medium during the mid-exponential growth phase (secretory proteins, SPs) to induce protective immunity against Mycobacterium tuberculosis H37Rv was studied in the mouse model. Mice immunized with SPs followed by a challenge with M. tuberculosis H37Rv showed lesser M. tuberculosis bacilli in their lung and spleen and survived longer than unimmunized controls. The findings suggest that SP antigens of M. habana are protective against tuberculosis infection.
Chaturvedi
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Division of Microbiology, Central Drug Research Institute, Chattar manzil, Post Box no. 173, Lucknow, India.
Jyoti
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Srivastava
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S
Gupta
H P
HP
D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology* / Q000302:isolation & purification / Q000378:metabolism; D015169:Colony Count, Microbial; D007114:Immunization; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D009161:Mycobacterium / Q000276:immunology* / Q000378:metabolism; D009169:Mycobacterium tuberculosis; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination
D001426:Bacterial Proteins