Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.
GABA(C) receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: rho1 (GABRR1), rho2 (GABRR2) and rho3 (GABRR3). We show that GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but that GABRR3 maps to chromosome 3q11-q13.3. Our mapping data suggest that the rho polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family.
Bailey
M E
ME
Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow, UK. mbailey@molgen.gla.ac.uk
Albrecht
B E
BE
Johnson
K J
KJ
Darlison
M G
MG
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D008040:Genetic Linkage; D006801:Humans; D008969:Molecular Sequence Data; D018079:Receptors, GABA / Q000235:genetics*; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B
C106350:GABRR2 protein, human; D018079:Receptors, GABA; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B