Changes of SOD-like substances in mouse organs after low-dose X-ray irradiation.
We demonstrated that low-dose irradiation with 50 cGy of X-ray induces in vivo production of superoxide dismutase (SOD)-like substances and accelerates antioxidant activity. To elucidate the defense mechanism against X-ray radiation, we examined which components among these SOD-like substances, such as SOD, vitamin C and celuroplasmin, are produced by low-dose irradiation. Our study revealed that SOD-like specific activity hardly involved SOD-like substances other than SOD. Moreover, it is suggested that low-dose irradiation induced synthesis and production of SOD itself, leading to elevation of SOD-specific activity.
Yamaoka
K
K
Faculty of Health Sciences, Okayama University Medical School, Japan.
Kojima
S
S
Nomura
T
T
D000818:Animals; D001853:Bone Marrow / Q000201:enzymology / Q000528:radiation effects; D001921:Brain / Q000201:enzymology / Q000528:radiation effects; D004912:Erythrocytes / Q000201:enzymology / Q000528:radiation effects; D008099:Liver / Q000201:enzymology / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism* / Q000528:radiation effects*; D014018:Tissue Distribution; D014916:Whole-Body Irradiation; D014965:X-Rays
D011506:Proteins; D013482:Superoxide Dismutase