New cytotoxic polyacetylenes from the marine sponge Petrosia.
New polyacetylenic alcohols with a C(45) carbon skeleton (2) and with an enone moiety in the alkyl chain (C(46), 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.
Lim
Y J
YJ
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Kim
J S
JS
Im
K S
KS
Jung
J H
JH
Lee
C O
CO
Hong
J
J
Kim
D k
Dk
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053279:Polyynes; D011161:Porifera / Q000737:chemistry*; D013539:Simian virus 40 / Q000235:genetics; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011108:Polymers; D053279:Polyynes; D000114:Acetylene