title: [Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report].
abstract: Nifedipine, as most calcium-antagonist drugs, is widely used for the treatment of angina pectoris and primary hypertension. Among its side effects, edema of lower limbs may expose patients to traumatic ulcers which become chronic. A case with painful ulcers and remarkable swelling of the ankles is reported. In this case, misdiagnosed as chronic venous insufficiency, good results were obtained with topical treatment and discontinuation of nifedipine. Leg ulcers and edema resolved in four months after ten years of disease history.
authors.affiliation: Cattedra e Scuola di Specializzazione, Chirurgia Vascolare, Ospedale Garibaldi, Università degli Studi, Catania.
authors.forename: S
authors.initials: S
authors.lastname: Luca
authors.forename: S
authors.initials: S
authors.lastname: Romeo
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001262:Atenolol / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004487:Edema / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007871:Leg Ulcer / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D009543:Nifedipine / Q000009:adverse effects*
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D001262:Atenolol; D009543:Nifedipine