Carcinosarcoma of the ampulla of Vater: a case report with immunohistochemical and ultrastructural studies.
Carcinosarcoma of the duodenum has not been reported previously, although this type of tumor has been detected in other organs. We present here a case of carcinosarcoma of the duodenum, including immunohistochemical and electron microscopical findings. An ulcerating tumor, located in the duodenal ampullary region, contained two divergent components: ordinary differentiated tubular adenocarcinoma, and sarcomatoid tissue composed of spindle tumor cells. Immunohistochemically, the adenocarcinoma cells were stained with antibodies against epithelial markers including keratin and CA19-9. In contrast, the sarcomatoid tissue was strongly positive for vimentin and was focally positive for myoglobin, keratin, and CA19-9. We speculate that the sarcomatoid element of the carcinosarcoma arose from part of the ordinary adenocarcinoma tissue.
Kijima
H
H
Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Takeshita
T
T
Suzuki
H
H
Tanahashi
T
T
Suto
A
A
Izumika
H
H
Miki
H
H
Terasaki
Y
Y
Nakamura
M
M
Watanabe
H
H
Tamaoki
N
N
Omiya
H
H
D014670:Ampulla of Vater; D014408:Biomarkers, Tumor / Q000032:analysis; D002296:Carcinosarcoma / Q000737:chemistry / Q000175:diagnosis* / Q000648:ultrastructure; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor