title: Conduction aphasia and the arcuate fasciculus: A reexamination of the Wernicke-Geschwind model.
abstract: Wernicke, and later Geschwind, posited that the critical lesion in conduction aphasia is in the dominant hemisphere's arcuate fasciculus. This white matter pathway was thought to connect the anterior language production areas with the posterior language areas that contain auditory memories of words (a phonological lexicon). Alternatively, conduction aphasia might be induced by cortical dysfunction, which impairs the phonological output lexicon. We observed an epileptic patient who, during cortical stimulation of her posterior superior temporal gyrus, demonstrated frequent phonemic paraphasias, decreased repetition of words, and yet had intact semantic knowledge, a pattern consistent with conduction aphasia. These findings suggest that cortical dysfunction alone may induce conduction aphasia.
authors.affiliation: Department of Neurology, University of Florida, Gainesville, USA. anderjm@medicine.ufl.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
authors.forename: R
authors.initials: R
authors.lastname: Gilmore
authors.forename: S
authors.initials: S
authors.lastname: Roper
authors.forename: B
authors.initials: B
authors.lastname: Crosson
authors.forename: R M
authors.initials: RM
authors.lastname: Bauer
authors.forename: S
authors.initials: S
authors.lastname: Nadeau
authors.forename: D Q
authors.initials: DQ
authors.lastname: Beversdorf
authors.forename: J
authors.initials: J
authors.lastname: Cibula
authors.forename: M
authors.initials: M
authors.lastname: Rogish
authors.forename: S
authors.initials: S
authors.lastname: Kortencamp
authors.forename: J D
authors.initials: JD
authors.lastname: Hughes
authors.forename: L J
authors.initials: LJ
authors.lastname: Gonzalez Rothi
authors.forename: K M
authors.initials: KM
authors.lastname: Heilman
mesh_terms: D018886:Aphasia, Conduction / Q000473:pathology*; D001041:Aphasia, Wernicke / Q000473:pathology; D001921:Brain / Q000473:pathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged