[The effect of bromantane on the erythro- and leukocytic profile of the peripheral blood in rats].
The specific effect of bromantan on blood tissue is demonstrated in rats. In chronic injection in a dose of 30 mg/kg bromantan raised the level of hemoglobin and leukocytes. In doses of 150 and 600 mg/kg it increased at first (3 months) and then reduced the level of erythrocytes, hemoglobin, and leukocytes. Reversible poikilocytosis, granulocytosis, and agranulocytosis were encountered. Hyperchromatosis and hypertrophy of the hepatocytes were found in the tissues of the liver and hemosiderosis was discovered in the spleen. It is suggested that the blood tissue is a "target" in the toxic effect of bromantan.
Bugaeva
L I
LI
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Spasov
A A
AA
Morozov
I S
IS
D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013997:Time Factors; D014914:Whole Blood Coagulation Time
D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane