Adaptive thermogenesis: orchestrating mitochondrial biogenesis.
The biogenesis of mitochondria requires products of the nuclear and mitochondrial genomes. Recent studies of adaptive thermogenesis have shown how mitochondrial proliferation and respiratory activity in brown fat and skeletal muscle are directed by the transcriptional coactivator PGC-1.
Butow
R A
RA
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235-9148, USA. butow@swmed.edu
Bahassi
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EM
D000222:Adaptation, Physiological; D017667:Adipocytes / Q000502:physiology; D002001:Adipose Tissue, Brown / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins; D018482:Muscle, Skeletal / Q000502:physiology; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
D004268:DNA-Binding Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C422562:mitochondrial transcription factor A; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1