title: Ultrasound-guided lumpectomy of nonpalpable breast cancers: A feasibility study looking at the accuracy of obtained margins.
abstract: OBJECTIVE
  Complete excision of a nonpalpable breast cancer after wire localization is a difficult procedure. Often, adequate margins are not obtained, and a second procedure is then required. Prospectively, we studied the feasibility of ultrasound-guided excisions of nonpalpable breast cancers, with particular attention to the accuracy of the procedure in obtaining adequate margins.
  
  
  METHODS
  Prospectively, 19 patients with 20 mammographically detected nonpalpable, highly suspect, breast tumors were entered in this feasibility study. In 15 of these, the diagnosis of invasive malignancy was established preoperatively. All patients underwent ultrasound-guided excision with the intent to obtain adequate margins. We also reviewed our own experience with the excision of nonpalpable breast cancers after wire localization.
  
  
  RESULTS
  Of the 20 excisions with ultrasound guidance, there were 19 carcinomas and 1 ductal carcinoma in situ. Of the 19 carcinomas, 17 (89%) were excised with adequate margins. Of the 43 carcinomas that were excised after wire localization, only 17 (40%) had been resected with adequate margins.
  
  
  CONCLUSIONS
  Ultrasound-guided excision appears to be a reliable procedure for obtaining adequate margins in the resection of nonpalpable breast cancers. Other advantages of this procedure are increased patient comfort and decrease in operating room time.
authors.affiliation: Department of Surgical Oncology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: F D
authors.initials: FD
authors.lastname: Rahusen
authors.forename: A H
authors.initials: AH
authors.lastname: Taets van Amerongen
authors.forename: P J
authors.initials: PJ
authors.lastname: van Diest
authors.forename: P J
authors.initials: PJ
authors.lastname: Borgstein
authors.forename: R P
authors.initials: RP
authors.lastname: Bleichrodt
authors.forename: S
authors.initials: S
authors.lastname: Meijer
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D010173:Palpation; D016217:Ultrasonography, Mammary