[Importance of microcirculatory disorders in combined treatment of acute pleural empyema and pyopneumothorax].
OBJECTIVE
To investigate responses to application of quick-frozen or cryosupernatant plasma, heparin and proteinases inhibitors of DIC-syndrome in patients with pleural empyema and pyopneumothorax.


METHODS
Transfusions of quick-frozen or cryosupernatant plasma, injections of heparin and inhibitors of proteinases were used as an adjuvant to conventional treatment in 548 patients with acute pleural empyema and pyopneumothorax.


RESULTS
The addition of cryoplasm-antienzyme complex to conventional treatment of acute pleural empyema resulted in reduced number of lethal outcomes compared to the conventional treatment alone (5.9 vs 14.4%, respectively).


CONCLUSIONS
Transfusion of quick-frozen or cryosupernatant plasma, injection of heparin and inhibitors of proteinases improve microcirculation around the inflammatory focus. In addition to antibiotic therapy and evacuation of the pus from the pleural cavity, the above methods contribute to better outcomes of pleural empyema and pyopneumothorax.
Tseĭmakh
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EA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use; D016913:Blood Component Transfusion; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D004359:Drug Therapy, Combination; D016724:Empyema, Pleural / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D010949:Plasma; D011030:Pneumothorax / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use
D000925:Anticoagulants; D015842:Serine Proteinase Inhibitors; D006493:Heparin; D007611:Aprotinin