title: Toxicity of French strains of the dinoflagellate Prorocentrum minimum experimental and natural contaminations of mussels.
abstract: Mediterranean strains of Prorocentrum minimum do not appear to have the same toxic component as Japanese strains since they showed no cytotoxicity for hepatocytes in culture. However, their toxic components, which appear to block calcium channels, were detectable by the immobilisation test on Diptera larvae. A bio-accumulation experiment in the laboratory showed that the toxins could accumulate in nearly equivalent amounts in the hepatopancreas and meat of cultured mussels. The same toxicity was found in natural samples collected in a period of bloom of P. minimum. These results suggest that P. minimum could be responsible for shellfish toxicity in the natural environment and thus present a risk for human health.
authors.affiliation: U.R.M. 11 Toxinologie marine, SMAB, Université de Nantes, ISO Mer, Faculté de Pharmacie, France.
authors.forename: A
authors.initials: A
authors.lastname: Denardou-Queneherve
authors.forename: D
authors.initials: D
authors.lastname: Grzebyk
authors.forename: Y F
authors.initials: YF
authors.lastname: Pouchus
authors.forename: M P
authors.initials: MP
authors.lastname: Sauviat
authors.forename: E
authors.initials: E
authors.lastname: Alliot
authors.forename: J F
authors.initials: JF
authors.lastname: Biard
authors.forename: B
authors.initials: B
authors.lastname: Berland
authors.forename: J F
authors.initials: JF
authors.lastname: Verbist
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000187:drug effects* / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism; D004141:Dinoflagellida; D004175:Diptera / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008387:Marine Toxins / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000633:toxicity*; D051379:Mice; D009498:Neurotoxins / Q000633:toxicity; D011893:Rana esculenta; D051381:Rats; D018675:Toxicity Tests
chemical_list: D008387:Marine Toxins; D009498:Neurotoxins