[Vitamin B6].
1934, vitamin B6 was discovered by P. György. Vitamin B6 consists of 3 closely related pyrimidine derivatives: pyridoxine, pyridoxal and pyridoxamine and their phosphate esters. The tumor-specific compound has been recently found to be as a new B6 derivatives. The active form of vitamin B6 is pyridoxal phosphate (PLP) which is produced by multi-metabolizing enzymes including pyridoxine kinase and PNP/PMP oxidase. PLP functions as the coenzymes of many enzymes which catalyze biochemical reactions such as transamination and decarboxylation. A novel physiological function of PLP which is the negative modulator of the steroid-dependent gene expression and the albumin gene expression has been also revealed.
Oka
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Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University.
D000818:Animals; D011736:Pyridoxine / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
D011736:Pyridoxine