title: Factor XI deficiency: implications for management of patients undergoing aesthetic surgery.
abstract: We report our experience in patients with an abnormal partial thromboplastin time elevation due to factor XI deficiency (Rosenthal syndrome) who presented for aesthetic surgery consideration. Preoperative evaluation included a thorough history, physical examination, coagulation profile, and hematological consultation. Nine of 10 patients underwent 12 elective aesthetic procedures without undue intraoperative or postoperative bleeding. Based on these findings, we stratified patients as low risk or high risk. Low-risk patients were those with greater than 15 percent factor XI levels, or those with 5 to 14 percent factor XI levels but a history of multiple major surgical procedures without bleeding complications. High-risk patients were those with factor XI levels less than 15 percent, history of bleeding either spontaneously or with surgery, and a family history of bleeding diathesis from factor XI deficiency. Low-risk patients had fresh frozen plasma available for the procedure, whereas high-risk patients received fresh frozen plasma 2 hours before surgery. We conclude that (1) in these patients with abnormally high partial thromboplastin time values and no prior known bleeding disorder, we have identified factor XI deficiency as the prevalent coagulopathy; (2) partial thromboplastin time does not necessarily correlate with factor XI levels; (3) patients can be classified as high or low risk for elective surgery based on factor XI levels and prior surgical or family history; (4) recommendations for perioperative management can be made based on this risk profile; and (5) aesthetic surgery can be performed successfully and safely on patients with factor XI deficiency on a case-by-case basis when appropriate guidelines are enforced.
authors.affiliation: Institute of Reconstructive Plastic Surgery, New York University Medical Center, Albert Einstein College of Medicine, NY, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Borud
authors.forename: A
authors.initials: A
authors.lastname: Matarasso
authors.forename: C M
authors.initials: CM
authors.lastname: Spaccavento
authors.forename: R M
authors.initials: RM
authors.lastname: Hanzlik
mesh_terms: D000293:Adolescent; D000328:Adult; D005173:Factor XI Deficiency / Q000150:complications / Q000235:genetics / Q000601:surgery*; D005260:Female; D006488:Hemostasis, Surgical; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010949:Plasma; D019106:Postoperative Hemorrhage / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D012307:Risk Factors; D013518:Surgery, Plastic