Recent advances in the enantioselective synthesis of beta-amino acids.
The introductory section of this review presents some of the currently most compelling beta-amino acid targets, according to their structural types: alpha- and beta-aryl substituted, olefinic and alkynyl, alpha, alpha- and alpha,beta-disubstituted, cyclic and conformationally restricted, fluorine-containing, and phosphonic analogous beta-amino acids. The main section highlights some of the very new (1996-1998), promising methodology for the enantioselective synthesis of beta-amino acids, with especial emphasis on catalytic and enzymatic processes, as well as methods based on "chiral pool", self-regeneration of stereogenic centers , diastereoselective nucleophilic additions to prochiral double bonds, and enantioselective reactions in the presence of chiral additives.
Juaristi
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Departamento de Química, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, México, 07000 D.F., México. juaristi@relaq.mx
López-Ruiz
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H
D000475:Alkenes / Q000737:chemistry; D004952:Esters / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry; D007097:Imines / Q000737:chemistry; D008094:Lithium / Q000737:chemistry; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry*
D000475:Alkenes; D004952:Esters; D007097:Imines; D009570:Nitriles; D009842:Oligopeptides; D005461:Fluorine; D008094:Lithium