title: Bladder cancer clinical guidelines panel summary report on the management of nonmuscle invasive bladder cancer (stages Ta, T1 and TIS). The American Urological Association.
abstract: OBJECTIVE
  The American Urological Association convened the Bladder Cancer Clinical Guidelines Panel to analyze the literature regarding available methods of treating nonmuscle invasive bladder cancer, and to make practice policy recommendations based primarily on treatment outcomes data.
  
  
  METHODS
  The panel searched the MEDLINE database for all articles related to nonmuscle invasive bladder cancer published from 1966 to January 1998. Outcomes data were extracted from articles accepted after panel review and meta-analyzed to produce comparative probability estimates for alternative treatments.
  
  
  RESULTS
  All of the intravesical agents (thiotepa, bacillus Calmette-Guerin, mitomycin C and doxorubicin) when used as adjuvant therapy after transurethral resection resulted in a lower probability of recurrence compared to resection alone. However, there is no evidence that intravesical therapy affects long-term progression.
  
  
  CONCLUSIONS
  For patients with no prior intravesical therapy adjuvant intravesical chemotherapy or immunotherapy is a treatment option after endoscopic removal of low grade Ta bladder cancers. Intravesical instillation of bacillus Calmette-Guerin or mitomycin C is recommended for carcinoma in situ, and after endoscopic removal of T1 and high grade Ta tumors.
authors.forename: J A
authors.initials: JA
authors.lastname: Smith
authors.forename: R F
authors.initials: RF
authors.lastname: Labasky
authors.forename: A T
authors.initials: AT
authors.lastname: Cockett
authors.forename: J A
authors.initials: JA
authors.lastname: Fracchia
authors.forename: J E
authors.initials: JE
authors.lastname: Montie
authors.forename: R G
authors.initials: RG
authors.lastname: Rowland
mesh_terms: D006801:Humans; D009367:Neoplasm Staging; D012106:Research; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*