Prevalence of coeliac disease in Turner syndrome.
This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA-antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were either AGA- or EMA-positive and further investigated with intestinal biopsy, four manifested villous atrophy (i.e. all three of the EMA-positive patients, but only one of the seven AGA-positive patients). The results suggest EMA-positivity to be a good immunological marker for use in screening for coeliac disease, and such screening to be justified in patients with Turner syndrome.
Ivarsson
S A
SA
Department of Paediatrics, University of Lund, University Hospital, Malmö, Sweden.
Carlsson
A
A
Bredberg
A
A
Alm
J
J
Aronsson
S
S
Gustafsson
J
J
Hagenäs
L
L
Häger
A
A
Kriström
B
B
Marcus
C
C
Moëll
C
C
Nilsson
K O
KO
Tuvemo
T
T
Westphal
O
O
Albertsson-Wikland
K
K
Aman
J
J
D000293:Adolescent; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000453:epidemiology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A; D015995:Prevalence; D013548:Sweden / Q000453:epidemiology; D014424:Turner Syndrome / Q000150:complications*
D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D005903:Gliadin