Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats.
OBJECTIVE
To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats.


METHODS
Controlled prospective study.


METHODS
Animal research laboratory.


METHODS
Four-month-old female Sprague-Dawley rats.


METHODS
Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups. Group I (five rats) was treated with vehicle (water); groups II and III (nine and eight rats, respectively) were treated with oral misoprostol at 100 and 200 microg/kg/d, respectively, for 60 days, after which blood was drawn again.


METHODS
Serum lipoprotein (a) levels.


RESULTS
The median lipoprotein (a) level before ovariectomy was 10.8 mg/dL (range, 10.6-46.5 mg/dL). Sixty days after ovariectomy, the level increased significantly to 15.9 mg/dL (range, 10.6-36.9 mg/dL). After treatment, there was no change in lipoprotein (a) levels in the vehicle-treated group (range, 16.3-21.1 mg/dL); however, the lipoprotein (a) levels decreased significantly in the group treated with 100 microg/kg/d of misoprostol, from 15.4 mg/dL to 10.8 mg/dL, and in the group treated with 200 microg/kg/d of misoprostol, from 17.1 mg/dL to 10.6 mg/dL.


CONCLUSIONS
Misoprostol caused a significant decrease in lipoprotein (a) levels.
Sonmez
A S
AS
Department of Obstetrics and Gynecology, Turgut Ozal Medical Center, Malatya, Turkey. suhas@aidata.net.tr
Birincioğlu
M
M
Turkoz
Y
Y
Adam
B
B
Lurie
D
D
Chuong
C J
CJ
D000818:Animals; D005260:Female; D017270:Lipoprotein(a) / Q000097:blood*; D016595:Misoprostol / Q000494:pharmacology*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
D017270:Lipoprotein(a); D016595:Misoprostol