title: Fetal brain infection with human parvovirus B19.
abstract: Intrauterine parvovirus B19 infection is known to be one of the causes of hydrops fetalis. However, there are few reports of the pathologic changes in the central nervous system. Postmortem examination of a fetus revealed multinucleated giant cells of macrophage/microglia lineage and many small calcifications around the vessels, predominantly in the cerebral white matter. Parvovirus B19 genome DNA was detected in the nucleus of the multinucleated giant cells and solitary endothelial cells by polymerase chain reaction amplification and in situ polymerase chain reaction methods. Capsid antigen was also demonstrated in the cytoplasm of the endothelial cells by immunofluorescent assay. Thus, intrauterine B19 parvovirus infection could be associated with marked neuropathologic changes in the fetal brain at the midembryonal period. Neurologic follow-up of complications may be necessary for children who survive the intrauterine infection.
authors.affiliation: Department of Mental Retardation, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Isumi
authors.forename: T
authors.initials: T
authors.lastname: Nunoue
authors.forename: A
authors.initials: A
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology / Q000821:virology*; D020805:Central Nervous System Viral Diseases / Q000150:complications* / Q000473:pathology / Q000821:virology; D005260:Female; D005313:Fetal Death; D005315:Fetal Diseases / Q000473:pathology / Q000821:virology*; D006801:Humans; D015160:Hydrops Fetalis / Q000473:pathology / Q000821:virology*; D007231:Infant, Newborn; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D012127:Respiratory Distress Syndrome, Newborn / Q000821:virology