title: Bronchiectasis with myeloperoxidase antineutrophil cytoplasmic antibody and bactericidal/permeability-increasing protein antineutrophil cytoplasmic antibody.
abstract: A 56-year-old woman was hospitalized for recurrent hemoptysis. She had been suffering from bronchiectasis for 4 years. Pseudomonas aeruginosa was persistently detected in her sputum. Serum was positive for Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) and bactericidal/permeability-increasing protein antineutrophil cytoplasmic antibody (BPI-ANCA). She underwent lung resection. Histopathologically, the resected lung showed bronchiectasis with pulmonary fibrosis but did not show vasculitis. Her serum became negative for the ANCAs after the operation. To date, she has no recurrence of hemoptysis. We discuss this case of bronchiectasis with MPO-ANCA and BPI-ANCA and suggest a possible role for ANCAs in chronic airway infection.
authors.affiliation: Department of Respiratory Medicine, National Minami-kyushu Hospital, Kagoshima.
authors.forename: W
authors.initials: W
authors.lastname: Matsuyama
authors.forename: J
authors.initials: J
authors.lastname: Wakimoto
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Hirotsu
authors.forename: A
authors.initials: A
authors.lastname: Mizoguchi
authors.forename: F
authors.initials: F
authors.lastname: Iwami
authors.forename: M
authors.initials: M
authors.lastname: Kawabata
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D023181:Antimicrobial Cationic Peptides; D001770:Blood Bactericidal Activity; D001798:Blood Proteins / Q000276:immunology*; D001987:Bronchiectasis / Q000150:complications / Q000276:immunology* / Q000601:surgery; D005260:Female; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008168:Lung / Q000473:pathology / Q000601:surgery; D008565:Membrane Proteins; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology*; D011552:Pseudomonas Infections / Q000150:complications
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008565:Membrane Proteins; C021623:bactericidal permeability increasing protein; D009195:Peroxidase