title: Information and redundancy: key concepts in understanding the genetic control of health and intelligence.
abstract: A model is proposed in which information from the environment is analysed by complex biological decision-making systems which are highly redundant. A correct response is intelligent behaviour which preserves health; incorrect responses lead to disease. Mutations in genes which code for the redundant systems will accumulate in the genome and impair decision-making. The number of mutant genes will depend upon a balance between the new mutation rate per generation and systems of elimination based on synergistic interaction in redundant systems. This leads to a polygenic pattern of inheritance for intelligence and the common diseases. The model also gives a simple explanation for some of the hitherto puzzling aspects of work on the genetic basis of intelligence including the recorded rise in IQ this century. There is a prediction that health, intelligence and socio-economic position will be correlated generating a health differential in the social hierarchy. Furthermore, highly competitive societies will place those least able to cope in the harshest environment and this will impair health overall. The model points to a need for population monitoring of somatic mutation in order to preserve the health and intelligence of future generations.
authors.affiliation: Royal Lancaster Infirmary, Lancaster, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Morris
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D008957:Models, Genetic