Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis.
Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of 13C-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve.
Schneiter
P
P
Institut de physiologie, Université de Lausanne, Switzerland.
Gillet
M
M
Chioléro
R
R
Jéquier
E
E
Tappy
L
L
D000328:Adult; D002247:Carbon Isotopes; D004435:Eating; D005260:Female; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000378:metabolism; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011517:Prothrombin Time; D012016:Reference Values; D014532:Uridine Diphosphate Glucose / Q000378:metabolism
D002247:Carbon Isotopes; D008112:Liver Glycogen; D005947:Glucose; D014532:Uridine Diphosphate Glucose; D005690:Galactose