title: Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits.
abstract: OBJECTIVE
  To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process.
  
  
  METHODS
  A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months.
  
  
  RESULTS
  Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation.
  
  
  CONCLUSIONS
  The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.
authors.affiliation: Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Nakayasu
authors.forename: Y
authors.initials: Y
authors.lastname: Hosoda
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: A
authors.initials: A
authors.lastname: Kanai
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D003315:Cornea / Q000737:chemistry / Q000503:physiopathology* / Q000601:surgery*; D007150:Immunohistochemistry; D020731:Keratomileusis, Laser In Situ; D011817:Rabbits; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003094:Collagen