title: Biological performance of a three-dimensional fabric as artificial cartilage in the repair of large osteochondral defects in rabbit.
abstract: A new artificial cartilage [A three-dimensional fabric (3-DF) comprising ultra-high molecular weight polyethylene fiber with a triaxial three-dimensional structure and coated with hydroxyapatite] was used to repair large osteochondral defects in rabbit knees. The knees with the 3-DF implanted in the osteochondral defects were evaluated 2-24 weeks after the operation macroscopically and microscopically. The 3-DF coated with hydroxyapatite was fixed firmly to the subchondral bone with the newly formed bone into and around the 3-DF. Hyaline-like cartilage was formed to a certain extent on the surface of the 3-DF, and the surface damage of the patella opposed to the 3-DF was minimal. In addition, the 3-DF caused no adverse effects such as particle disease, infection or severe synovitis during the experimental period. Consequently, the 3-DF seems to have successful biocompatibility in this rabbit experiment.
authors.affiliation: Department of Orthopedic Surgery, Faculty of Medicine, Mie University, Tsu City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: A
authors.initials: A
authors.lastname: Sudo
authors.forename: Y
authors.initials: Y
authors.lastname: Shikinami
authors.forename: A
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000503:physiopathology; D017886:Durapatite; D005260:Female; D007596:Joints / Q000601:surgery*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010007:Osteochondritis / Q000601:surgery*; D010012:Osteogenesis; D010329:Patella / Q000601:surgery*; D011095:Polyethylenes; D019736:Prostheses and Implants; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology / Q000503:physiopathology
chemical_list: D011095:Polyethylenes; D017886:Durapatite