Human papillomavirus typing and the reduction of cervical cancer risk.
Minor cervical cytologic abnormalities are common, but knowing which low-grade lesions will progress to cervical cancer--and therefore deserve biopsy and excision--is difficult. Since some human papillomavirus (HPV) types are strongly associated with cervical cancer, HPV typing may be a means of determining which patients with minor abnormalities require biopsy and treatment and which need only follow-up smears. This paper reviews the association between cervical cancer and HPV infection, the pathogenesis of HPV infection, the utility of HPV typing in training patients with a diagnosis of atypical squamous cells of undetermined significance, and the prospects for the development of an HPV vaccine.
Jin
X W
XW
Department of General Internal Medicine, Cleveland Clinic, USA. jinx@ccf.org
Cash
J
J
Kennedy
A W
AW
D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control / Q000821:virology*; D014626:Vaginal Smears; D014765:Viral Vaccines
D014765:Viral Vaccines