title: Ectopic corticotroph adenoma in the cavernous sinus: case report.
abstract: OBJECTIVE
  Adrenocorticotropin (ACTH)-secreting pituitary adenomas causing Cushing's disease are often difficult to identify because of their variable locations and their small size. This report presents histological evidence of an ectopic ACTH-secreting adenoma located entirely within the cavernous sinus.
  
  
  METHODS
  A 62-year-old woman presented with central obesity, hypertension, and osteoporosis. Endocrinological evaluation suggested the presence of an ACTH-secreting pituitary adenoma; however, imaging studies, including dynamic magnetic resonance imaging, did not reveal any visible lesions in the pituitary gland. Bilateral cavernous sinus sampling demonstrated a large central/peripheral ACTH gradient, with a right/left ACTH gradient. The patient was treated as having pituitary-dependent Cushing's disease, until she died suddenly as a result of acute respiratory failure.
  
  
  METHODS
  In a postmortem histological examination, an ACTH-secreting adenoma was found in the right cavernous sinus, which was completely surrounded by dura mater and had no direct connection with the pituitary gland.
  
  
  CONCLUSIONS
  Although they are rare, such adenomas located in the cavernous sinus should be recognized as one of the reasons for inaccurate cavernous sinus sampling and the failure of transsphenoidal surgery for patients with ACTH-dependent Cushing's syndrome.
authors.affiliation: Department of Neurosurgery and Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sanno
authors.forename: S
authors.initials: S
authors.lastname: Tahara
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Onose
authors.forename: I
authors.initials: I
authors.lastname: Wakabayashi
authors.forename: A
authors.initials: A
authors.lastname: Teramoto
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D002426:Cavernous Sinus / Q000473:pathology; D003645:Death, Sudden / Q000473:pathology; D004388:Dura Mater / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008797:Metyrapone / Q000627:therapeutic use; D008875:Middle Aged; D010690:Phlebography; D010902:Pituitary Gland / Q000473:pathology; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D008797:Metyrapone