title: Breast cancer and timing of surgery during menstrual cycle: a 5-year analysis of 248 premenopausal women.
abstract: In the present report, we retrospectively analyzed the impact of the timing of surgery during menstrual cycle on disease-free and overall survival of 248 premenopausal patients with stage I/II breast cancer who underwent surgery followed by anthracycline-containing adjuvant chemotherapy. With a median follow-up of 5 years, no statistically significant differences were observed in disease-free or overall survival between women operated upon during the follicular (days 0-14) and the luteal (days 15-32) phase of the menstrual cycle. The impact on disease-free and overall survival of lymph-node status, tumor size and hormone receptor expression, but not of the phase of the menstrual cycle at the time of surgery, was confirmed by univariate and multivariate analysis. However, when combined with hormone receptor status, the phase of the menstrual cycle at the time of surgery proved useful to better define the prognosis of primary breast cancer patients, with significantly longer disease-free and overall survival for patients operated upon during the follicular phase and with positive hormone receptors.
authors.affiliation: Division of Medical Oncology I, Regina Elena Cancer Institute, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Milella
authors.forename: C
authors.initials: C
authors.lastname: Nisticò
authors.forename: V
authors.initials: V
authors.lastname: Ferraresi
authors.forename: A
authors.initials: A
authors.lastname: Vaccaro
authors.forename: A
authors.initials: A
authors.lastname: Fabi
authors.forename: A M
authors.initials: AM
authors.lastname: D'Ottavio
authors.forename: C
authors.initials: C
authors.lastname: Botti
authors.forename: D
authors.initials: D
authors.lastname: Giannarelli
authors.forename: M
authors.initials: M
authors.lastname: Lopez
authors.forename: E
authors.initials: E
authors.lastname: Cortesi
authors.forename: C M
authors.initials: CM
authors.lastname: Foggi
authors.forename: M
authors.initials: M
authors.lastname: Antimi
authors.forename: E
authors.initials: E
authors.lastname: Terzoli
authors.forename: F
authors.initials: F
authors.lastname: Cognetti
authors.forename: P
authors.initials: P
authors.lastname: Papaldo
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D015999:Multivariate Analysis; D017697:Premenopause; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012189:Retrospective Studies; D016019:Survival Analysis