Influence of age, diagnosis, and cycle number on pregnancy rates with gonadotropin-induced controlled ovarian hyperstimulation and intrauterine insemination.
OBJECTIVE
To determine whether age, diagnosis, and cycle number influence cycle fecundity associated with gonadotropin-induced controlled ovarian hyperstimulation/IUI.


METHODS
Retrospective analysis.


METHODS
The Center for Reproductive Medicine at the Brigham and Women's Hospital, a tertiary care academic medical center.


METHODS
Two hundred seventy-four women who underwent controlled ovarian hyperstimulation with gonadotropins and IUI.


METHODS
Infertility treatment with gonadotropins and IUI.


METHODS
Pregnancy rates according to patient age, infertility diagnosis, and number of treatment cycles.


RESULTS
Pregnancy rates decreased with increasing patient age. The cumulative pregnancy rates varied greatly by diagnosis from 13% for patients with male factor infertility to 84% for patients with ovulatory factor infertility. Average cycle fecundity was considerably less varied by diagnosis. All pregnancies among patients with male factor infertility and tubal factor infertility were achieved during the first two cycles.


CONCLUSIONS
There is a clear age-related decline in fecundity associated with gonadotropin-induced controlled ovarian hyperstimulation/IUI. Patients <40 years of age and those with male factor infertility or tubal factor infertility have a particularly poor prognosis.
Sahakyan
M
M
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Harlow
B L
BL
Hornstein
M D
MD
D000328:Adult; D000375:Aging; D000858:Anovulation / Q000150:complications; D004715:Endometriosis / Q000150:complications; D005184:Fallopian Tube Diseases / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007246:Infertility / Q000209:etiology* / Q000628:therapy; D007248:Infertility, Male / Q000628:therapy; D007317:Insemination, Artificial, Homologous; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D008875:Middle Aged; D010062:Ovulation Induction; D011247:Pregnancy; D012189:Retrospective Studies
D008596:Menotropins; D005640:Follicle Stimulating Hormone