Hypertriglyceridemia in rats induced by consumption of a food-derived carcinogen, 2-amino-1-methyl-phenylimidazo[4,5b]pyridine (PhIP).
2-Amino-1-methyl-phenylimidazo[4,5b]pyridine (PhIP), the most abundant mutagenic heterocyclic amine produced in cooked meat and fish, is known to be a carcinogen for rats and mice. This study provides the first evidence for hypertriglyceridemia in rats exposed to PhIP, suggesting its potential risk to induce not only carcinogenesis, but also atherosclerosis, and highlighting the potential importance of PhIP for humans.
Isimura
Y
Y
Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan.
Watanabe
H
H
Kato
N
N
Yanagita
T
T
Wakabayashi
K
K
D000818:Animals; D001161:Arteriosclerosis / Q000139:chemically induced; D002273:Carcinogens / Q000302:isolation & purification / Q000633:toxicity*; D005504:Food Analysis; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D007093:Imidazoles / Q000302:isolation & purification / Q000633:toxicity*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344
D002273:Carcinogens; D007093:Imidazoles; D008055:Lipids; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine