title: Sperm dysfunction in subfertile patients with varicocele and marginal semen analysis.
abstract: A comparative analysis of potentially functional spermatozoa per ejaculate, progressive motility, hypo-osmotic swelling test, acrosome integrity and sperm viability (24 and 48 h) was carried out in a group of 40 subfertile patients with varicocele and marginal semen analysis and 40 fertile subjects, in order to identify subclinical abnormalities that may explain subfertility. Patients with varicocele had lower numbers of potentially functional spermatozoa per ejaculate, progressive motility, acrosome and membrane integrity and sperm viability. These abnormalities were not related to the grade of varicocele, testicular volume or serum FSH concentration. A positive correlation between the hypo-osmotic swelling test and progressive motility (r = 0.71) and between potentially functional spermatozoa and the hypo-osmotic swelling test (r = 0.69) was found in patients with varicocele. These data suggest that some of the deleterious effects produced by the varicocele might be related to sperm migration and viability in the female genital tract and others to sperm-zona interaction and/or sperm-egg fusion.
authors.affiliation: Clinica de Andrología, Instituto Nacional de Perinatología, México D.F., México.
authors.forename: C A
authors.initials: CA
authors.lastname: Villanueva-Diaz
authors.forename: E A
authors.initials: EA
authors.lastname: Vega-Hernandez
authors.forename: M A
authors.initials: MA
authors.lastname: Diaz-Perez
authors.forename: M
authors.initials: M
authors.lastname: Echavarria-Sanchez
authors.forename: S
authors.initials: S
authors.lastname: Karchmer-Krivitsky
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology*; D008297:Male; D012661:Semen / Q000166:cytology; D013081:Sperm Motility; D013094:Spermatozoa; D014646:Varicocele / Q000503:physiopathology*
chemical_list: D005640:Follicle Stimulating Hormone