title: Pregnancies resulting from in vitro matured oocytes retrieved from patients with polycystic ovary syndrome after priming with human chorionic gonadotropin.
abstract: OBJECTIVE
  To describe pregnancies that resulted from in vitro matured oocytes derived from two unstimulated, anovulatory patients with polycystic ovary syndrome after priming with hCG before oocyte retrieval.
  
  
  METHODS
  Case series.
  
  
  METHODS
  McGill Reproductive Center, Royal Victoria Hospital, McGill University.
  
  
  METHODS
  Two women with polycystic ovary syndrome.
  
  
  METHODS
  Progesterone induction of a withdrawal bleeding episode. The administration of subcutaneous hCG 36 hours before oocyte retrieval in a natural menstrual cycle. In vitro maturation of immature oocytes, fertilization, and ET. Luteal support with oral estrogen and progesterone.
  
  
  METHODS
  Pregnancy outcome.
  
  
  RESULTS
  Two clinical pregnancies were confirmed after oocyte maturation in vitro, fertilization with intracytoplasmic sperm injection, and ET.
  
  
  CONCLUSIONS
  The administration of hCG 36 hours before harvesting of immature oocytes may improve the maturational and developmental competence of the oocytes and the pregnancy rates of unstimulated patients with polycystic ovary syndrome.
authors.affiliation: McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada. rchian@rvhob2.lan.mcgill.ca
authors.forename: R C
authors.initials: RC
authors.lastname: Chian
authors.forename: W M
authors.initials: WM
authors.lastname: Buckett
authors.forename: L L
authors.initials: LL
authors.lastname: Too
authors.forename: S L
authors.initials: SL
authors.lastname: Tan
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000473:pathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting
chemical_list: D006063:Chorionic Gonadotropin