Dehydrophenylalanine analogues: conformational characterization.
Few dehydrophenylalanine (deltaPhe) analogues (X-deltaPhe-Phe-Gly-X1, X = Ac-; Boc-; Z-; X1 = OMe; OH; ONH2) of virus replication inhibiting peptide (Z-D-Phe-Phe-Gly) were synthesized, and their solution conformations were investigated by 1H NMR, UV and circular dichroism (CD) spectroscopy. Homogeneity of these analogues was also assessed by reverse phase-high performance liquid chromatography (RP-HPLC) using water-acetonitrile gradients.
Siddiqui
M Z
MZ
National Biotechnology Centre, Indian Veterinary Research Institute, Uttar Pradesh.
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000302:isolation & purification; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D009842:Oligopeptides; D010455:Peptides; D010649:Phenylalanine; C018632:phenyldehydroalanine; C050811:carbobenzoxyphenylalanyl-phenylalanyl-glycine