title: Acute lymphoblastic leukaemia occurring as second malignancy: report of the GIMEMA archive of adult acute leukaemia. Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto.
abstract: Between July 1992 and June 1996, 901 new cases of adult acute lymphoblastic leukaemia were recorded in the GIMEMA Archive of Adult Acute Leukaemia; 21 of them (2.3%) had a previous primary malignancy (PM). We found that secondary acute lymphoblastic leukaemia cases (sALL) presented with older age, a high incidence of pre-pre-B immunophenotype and a significantly higher prevalence of cancer among relatives compared to de novo ALL. The leukaemogenic activity of the cytotoxic drugs employed for the treatment of PM may have played a potential role in only a proportion of patients, opening the possibility that some sALL patients may have developed two or more malignancies due to individual predisposing factors.
authors.affiliation: Department of Haematology, Catholic University, Largo Francesco Vito, I-00168 Roma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pagano
authors.forename: A
authors.initials: A
authors.lastname: Pulsoni
authors.forename: M E
authors.initials: ME
authors.lastname: Tosti
authors.forename: L
authors.initials: L
authors.lastname: Annino
authors.forename: A
authors.initials: A
authors.lastname: Mele
authors.forename: A
authors.initials: A
authors.lastname: Camera
authors.forename: B
authors.initials: B
authors.lastname: Martino
authors.forename: C
authors.initials: C
authors.lastname: Guglielmi
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: E
authors.initials: E
authors.lastname: Di Bona
authors.forename: R
authors.initials: R
authors.lastname: Invernizzi
authors.forename: C
authors.initials: C
authors.lastname: Castagnola
authors.forename: R
authors.initials: R
authors.lastname: Bassan
authors.forename: L
authors.initials: L
authors.lastname: Mele
authors.forename: G
authors.initials: G
authors.lastname: Todeschini
authors.forename: G
authors.initials: G
authors.lastname: Leone
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*