title: Primary association of a TNF gene polymorphism with susceptibility to multiple sclerosis.
abstract: The associations of three promoter polymorphisms in the tumor necrosis factor (TNFA) gene have been studied in 238 patients and 324 control subjects. A significant correlation was found between MS susceptibility and the TNFA-376 polymorphism. This association was independent of the human leukocyte antigen (HLA) class II association and the combined inheritance of HLA-DRB1*1501 and the TNFA-376A allele more than additively increased susceptibility to MS.
authors.affiliation: Department of Immunology, San Carlos University Hospital, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Fernandez-Arquero
authors.forename: R
authors.initials: R
authors.lastname: Arroyo
authors.forename: A
authors.initials: A
authors.lastname: Rubio
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: P
authors.initials: P
authors.lastname: Vigil
authors.forename: L
authors.initials: L
authors.lastname: Conejero
authors.forename: M A
authors.initials: MA
authors.lastname: Figueredo
authors.forename: E G
authors.initials: EG
authors.lastname: de la Concha
mesh_terms: D000483:Alleles; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha