title: Radiopaque acrylic cements prepared with a new acrylic derivative of iodo-quinoline.
abstract: A novel iodine-containing methacrylate, 2,5-diiodo-8-quinolyl methacrylate, has been synthesized and used in the preparation of acrylic radiopaque cements. The effect of incorporation of this monomer to the self-curing resins, on the curing parameters, swelling behaviour and mechanical properties was studied. The incorporation of the radiopaque compound 2,5-diiodo-8-hydroxyquinoline to the solid phase was also carried out for comparative experiments. A decrease in the peak temperature and an increase in the setting time was observed with the addition of the radiopaque monomer, however, the curing parameters did not appreciably change with the addition of the radiopaque compound to the solid phase. Swelling of the modified cements was in the same range as that of the radiolucent cement; however, the diffusion coefficients calculated according to the Fick's law were higher for the iodine-containing materials. The addition of 5 wt% of the iodine-containing methacrylate provided a significant increase in the tensile properties with respect to either control radiolucent formulations or BaSO4-containing formulations. Biocompatibility of the modified cements was studied by implantation of rods of the cements into rats and histological analysis of the surrounding tissue.
authors.affiliation: Macromolecular Chemistry Department, Instituto de Ciencia y Technologia de Polímeros, CSIC, Madrid, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Vázquez
authors.forename: M P
authors.initials: MP
authors.lastname: Ginebra
authors.forename: F J
authors.initials: FJ
authors.lastname: Gil
authors.forename: J A
authors.initials: JA
authors.lastname: Planell
authors.forename: A
authors.initials: A
authors.lastname: López Bravo
authors.forename: J
authors.initials: J
authors.lastname: San Román
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001843:Bone Cements / Q000138:chemical synthesis*; D003287:Contrast Media / Q000138:chemical synthesis*; D020007:Implants, Experimental; D017613:Iodine Compounds / Q000138:chemical synthesis / Q000737:chemistry; D008689:Methacrylates / Q000138:chemical synthesis*; D008768:Methylmethacrylates / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats
chemical_list: C401927:2,5-diiodo-8-quinolyl methacrylate; D001672:Biocompatible Materials; D001843:Bone Cements; D003287:Contrast Media; D017613:Iodine Compounds; D008689:Methacrylates; D008768:Methylmethacrylates; D011804:Quinolines