A comparison of cryotherapy versus diode laser retinopexy in 100 consecutive infants treated for threshold retinopathy of prematurity.
OBJECTIVE
The purpose of this paper is to present a series of patients who were treated for threshold retinopathy of prematurity with either cryotherapy or diode laser. Complications and unfavorable outcomes during the first year after treatment will be compared for the two procedures.


METHODS
The clinical courses of a consecutive series of 100 infants (192 eyes) were reviewed. All infants had their threshold status confirmed by a second examiner. Infants were treated with cryotherapy through 1993 and with diode laser thereafter. One hundred two eyes of 54 patients were treated with cryotherapy. Ninety eyes of 46 patients were treated with laser retinopexy. Two of the patients who were treated with laser (4 eyes) did not survive to the 3-month follow-up visit, and their results are not included here. The two groups of infants were comparable in their birth weight, adjusted gestational age at treatment, and severity of disease as determined by zone and sectors of stage 3 retinopathy of prematurity.


RESULTS
Unfavorable outcome (total retinal detachment) was seen in 25.4% of eyes treated with cryotherapy (26 of 102), as compared with 15% of eyes treated with laser (13 of 86). Two cataracts were seen in our patients: one patient 22 weeks after cryotherapy, and the other 7 months after diode laser.


CONCLUSIONS
No statistically significant difference was found in the rate of retinal detachments in the two groups (X2 = 3.05; P = .08).
McGregor
M L
ML
Children's Hospital, Ohio State University Department of Ophthalmology, Columbus 43205-2696, USA.
Wherley
A J
AJ
Fellows
R R
RR
Bremer
D L
DL
Rogers
G L
GL
Letson
A D
AD
D001724:Birth Weight; D017679:Cryotherapy / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017075:Laser Coagulation / Q000009:adverse effects; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control; D012178:Retinopathy of Prematurity / Q000150:complications / Q000601:surgery*; D016896:Treatment Outcome