Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity.
A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free omega-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit.
Dai
W M
WM
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China.
Chow
C W
CW
Zhou
L
L
Ishii
A
A
Lau
C W
CW
Li
Q
Q
Hamaguchi
W
W
Nishimoto
S
S
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D004279:DNA, Viral / Q000737:chemistry; D004587:Electrophoresis, Agar Gel; D007364:Intercalating Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis*; D013450:Sulfones / Q000138:chemical synthesis*
D018906:Antineoplastic Agents, Alkylating; D004279:DNA, Viral; D007364:Intercalating Agents; D009281:Naphthalenes; D013450:Sulfones