[The effect of polikatan on the ototoxic action of kanamycin].
Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.
Spasov
A A
AA
Volgograd State Medical Academy, Russia.
Lobzov
M S
MS
Sanzharovskaia
N K
NK
Kozhevnikova
E V
EV
Kuzubova
E A
EA
D000161:Acoustic Stimulation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000517:prevention & control*; D007478:Iontophoresis; D007612:Kanamycin / Q000633:toxicity*; D015636:Magnesium Chloride / Q000008:administration & dosage*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015636:Magnesium Chloride; D007612:Kanamycin