[Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].
We compared thermostability of various natural (sulfoprolamine and sodium usnate) or synthetic (climbazol and piroctone olamine) antidandruff agents in aqueous diluted solution at pH around 7. Thermodegradation of these solutions was studied by an isothermal method in thermostatically controlled ovens, at three temperatures (50, 70 and 90 degrees C). For each molecule, we determined at 20 degrees C t90% (time necessary to obtain a decrease of 10% of the initial concentration, value which shows the stability of the product). The present study shows that piroctone olamine is the most stable antidandruff agent among those studied.
Coiffard
C
C
Laboratoire de Pharmacie industrielle, UFR de Pharmacie, Nantes.
Coiffard
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L
de Roeck-Holtzhauer
Y
Y
D003879:Dermatologic Agents / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D004983:Ethanolamines / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D006358:Hot Temperature; D007093:Imidazoles / Q000737:chemistry*; D011412:Propanolamines / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*
D003879:Dermatologic Agents; D004338:Drug Combinations; D004983:Ethanolamines; D006575:Heterocyclic Compounds, 3-Ring; D007093:Imidazoles; D011412:Propanolamines; D011728:Pyridones; C400715:sodium usnate; C108286:climbazole; C052599:piroctone olamine