title: Two 6-substituted 5,6-dihydro-alpha-pyrones from Ravensara anisata.
abstract: The leaves and bark dichloromethane extracts of Ravensara anisata showed antifungal activity against the yeast Candida albicans and the phytopathogenic fungus Cladosporium cucumerinum in bioautographic TLC assays. Activity-guided fractionation afforded two new alpha-pyrones: 6R*-(4R*-acetoxy-2S*-hydroxy- 8-phenyloctyl)-5,6-dihydro-2-H-pyran-2-one and 6R*-(2S*-acetoxy-4R*- hydroxy-8-phenyloctyl)-5,6-dihydro-2-H-pyran-2-one. Their structures have been established by NMR spectroscopy, chemical methods and X-ray crystallographic analysis. The antifungal activity against C. albicans and C. cucumerinum was determined for both compounds.
authors.affiliation: Centre National de Recherches Industrielles et Technologiques, Antananarivo, Madagascar.
authors.forename: J O
authors.initials: JO
authors.lastname: Andrianaivoravelona
authors.forename: S
authors.initials: S
authors.lastname: Sahpaz
authors.forename: C
authors.initials: C
authors.lastname: Terreaux
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
authors.forename: H
authors.initials: H
authors.lastname: Stoeckli-Evans
authors.forename: J
authors.initials: J
authors.lastname: Rasolondramanitra
mesh_terms: D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002850:Chromatography, Gel; D018360:Crystallography, X-Ray; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D011753:Pyrones