The potential of neuroprotection in glaucoma treatment.
Visual field loss in glaucoma is due to death of retinal ganglion cells. Reducing or slowing down the loss of ganglion cells in glaucoma, a concept known as neuroprotection, would appear to be the only way forward. This does not imply that treatment of risk factors, such as elevated intraocular pressure, must not be continuously implemented. In this paper we point out that very little is known about the mechanisms of ganglion cell death in glaucoma and that data derived from studies on the "ideal animal model for glaucoma" must not be overemphasized. We also propose that the death processes of neurones in various diseases are fundamentally the same but vary in cause. Experimental data show that the death rate of neuronal populations is dependent on the impact of the insult and that neuroprotectants are more likely to benefit a patient in diseases in which the neurones die slowly, as in glaucoma, than in a disease in which the death of a set of neurones is rapid. We conclude that if a putative neuroprotectant can be administered in such a way that it reaches the retina in appropriate amounts and has insignificant side effects, it is likely to attenuate ganglion cell death and thus benefit the glaucoma patient.
Osborne
N N
NN
Nuffield Laboratory of Ophthalmology, Oxford University, UK.
Chidlow
G
G
Nash
M S
MS
Wood
J P
JP
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D005901:Glaucoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000473:pathology; D014794:Visual Fields
D018696:Neuroprotective Agents