Chronic alcohol consumption increases serum levels of circulating endothelial cell/leucocyte adhesion molecules E-selectin and ICAM-1.
A group of 30 chronic alcoholics without alcohol-related diseases and 30 controls (teetotallers) were selected to measure serum levels of endothelial adhesion molecules (AMs) (ICAM-1, VCAM-1, and E-selectin). ICAM-1 and E-selectin serum levels were higher in alcoholics, whereas VCAM-1 serum levels were similar in both groups. There was a significant correlation between daily alcohol intake and serum level of ICAM-1 (r = 0.49, P = 0.003) and E-selectin (r = 0.41, P = 0.02). A significant positive correlation between E-selectin and total lifetime dose of ethanol was also observed (r = 0.52, P = 0.003). These changes in serum levels of endothelial AMs of chronic alcoholics may reflect endothelial and/or immune activation, and could interfere with the reactions between immune cells and the endothelium.
Sacanella
E
E
Department of Internal Medicine, Hospital Clínic, Institut d'Investigació Biomèdica Agustí Pi Sunyer, University of Barcelona, Spain.
Estruch
R
R
Badía
E
E
Fernández-Sola
J
J
Nicolás
J M
JM
Urbano-Márquez
A
A
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002492:Central Nervous System Depressants / Q000494:pharmacology; D019040:E-Selectin / Q000097:blood* / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008875:Middle Aged; D013695:Temperance; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015415:Biomarkers; D002492:Central Nervous System Depressants; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D000431:Ethanol