title: Differences in lung bioavailability between different propellants for fluticasone propionate.
abstract: The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.
authors.forename: A M
authors.initials: AM
authors.lastname: Wilson
authors.forename: E J
authors.initials: EJ
authors.lastname: Sims
authors.forename: L C
authors.initials: LC
authors.lastname: Orr
authors.forename: B J
authors.initials: BJ
authors.lastname: Lipworth
mesh_terms: D000328:Adult; D000335:Aerosol Propellants; D000730:Androstadienes / Q000493:pharmacokinetics*; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D017402:Chlorofluorocarbons; D004305:Dose-Response Relationship, Drug; D000068298:Fluticasone; D006801:Humans; D006845:Hydrocarbons, Fluorinated; D006854:Hydrocortisone / Q000652:urine; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D016037:Single-Blind Method; D005466:Fluorocarbons
chemical_list: D000335:Aerosol Propellants; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D017402:Chlorofluorocarbons; D000068298:Fluticasone; D006845:Hydrocarbons, Fluorinated; D006854:Hydrocortisone; C094049:apaflurane; D005466:Fluorocarbons