Exclusion of Leu1 and Leu2 genes as tumor suppressor genes in 13q14.3-deleted B-CLL.
The chromosomal region 13q14.3 is frequently deleted in B cell chronic lymphocytic leukemia (B-CLL) and it is supposed that a tumor suppressor gene, involved in this leukemogenesis, is located in this area. The first exons of two genes, Leu1 and Leu2, mapped in a minimally deleted 13q14.3 region, are systematically lost in B-CLL sharing a 13q14.3 deletion. These two genes have been proposed as strong tumor suppressor gene candidates. However, in a study on 15 13q14.3 deleted B-CLL, we found three patients in which this critical region was not involved. Because of these results and that no mutations were detected on the two genes in a previous study, we think that Leu1 and Leu2 can be excluded as tumor suppressor genes.
Rondeau
G
G
INSERM U463, Institut de Biologie de l'Hôtel-Dieu, Centre Hospitalier Universitaire, 44093 Nantes cedex, France.
Moreau
I
I
Bézieau
S
S
Cadoret
E
E
Moisan
J P
JP
Devilder
M C
MC
D018956:CD5 Antigens / Q000235:genetics*; D016827:CD8 Antigens / Q000235:genetics*; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D016147:Genes, Tumor Suppressor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D019656:Loss of Heterozygosity; D016133:Polymerase Chain Reaction
D018956:CD5 Antigens; D016827:CD8 Antigens