A Novel Dinuclear Diaminoplatinum(II) Glutathione Macrochelate.
Both oxidized and reduced glutathione (gamma-L-Glu-L-Cys-Gly) react with the anticancer complex [Pt(en)Cl(2)] to form the bicyclic complex illustrated (en=ethylenediamine). This unprecedented structure, which was determined from extensive NMR experiments, contains a ten-membered macrochelate ring.
del Socorro Murdoch P
Department of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ (UK).
Kratochwil
NA
Parkinson
JA
Patriarca
M
Sadler
PJ