Seroreactivity to human papillomavirus types 16, 18, 31, and 45 virus-like particles in a case-control study of cervical squamous intraepithelial lesions.
Serum IgG antibodies to human papillomavirus (HPV) types 16, 18, 31, and 45 virus-like particles were measured in a nested case-control study of cervical squamous intraepithelial lesions. HPV-16 seroreactivity was strongly associated with HPV-16 DNA detection (odds ratio, 9.0; 95% confidence interval, 4.4-19.4), and similar type specificity was observed for HPV-31 and -45. In contrast, seroreactivity to any type was associated with elevated seroreactivity to all others. Among cases and controls, HPV-16 showed the highest seroprevalence, with 23.8% of 80 cases and 10.5% of 258 controls seroreactive to HPV-16 alone, and another 27.5% and 5.4%, respectively, seroreactive to HPV-16 plus other types. Overall, 24 (30.0%) cases and 17 (6.6%) controls were seroreactive to multiple types. These data suggest that seroreactivity to a given type reflects mainly type-specific HPV infection as measured by DNA detection and may also signal past exposure to other types that are now only serologically detected.
Wideroff
L
L
NCI/ARB, EPN 313 MSC 7344, Bethesda, MD 20892-7344, USA. wideroff@nih.gov
Schiffman
M
M
Haderer
P
P
Armstrong
A
A
Greer
C E
CE
Manos
M M
MM
Burk
R D
RD
Scott
D R
DR
Sherman
M E
ME
Schiller
J T
JT
Hoover
R N
RN
Tarone
R E
RE
Kirnbauer
R
R
D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D003429:Cross Reactions; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014771:Virion / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*
D000914:Antibodies, Viral; D004279:DNA, Viral