[Severe hemorrhage, lymphocytosis and leukoerythroblastic blood picture--disseminated intravascular coagulation in metastatic prostate carcinoma and chronic lymphatic leukemia].
Hemorrhagic complications in CLL are most often related to thrombocytopenia either due to decreased megakaryopoiesis caused by diffuse lymphocytic bone marrow infiltration or to increased peripheral platelet consumption by platelet autoantibodies (immune thrombocytopenia), both being typical manifestations of the disease. Disseminated intravascular coagulation (DIC) does not belong to the spectrum of CLL-related complications. In the case here reported with DIC and newly diagnosed CLL the leukoerythroblastic blood changes hinted to bone marrow infiltration by another neoplastic process in addition to CLL. Bone marrow biopsy revealed infiltration by metastatic carcinoma of the prostate in addition to that by CLL, the former being responsible for triggering severe DIC leading to fatal intracranial bleeding.
Solenthaler
M
M
Hämatologisches Zentrallabor der Universität, Inselspital, Bern.
Lämmle
B
B
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000473:pathology*; D004900:Erythroblasts / Q000473:pathology; D020200:Hematoma, Subdural, Chronic / Q000473:pathology; D006474:Hemorrhagic Disorders / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D007964:Leukocytosis / Q000473:pathology; D008218:Lymphocytosis / Q000473:pathology; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*