["Floppy infant" syndrome in twins secondary to the use of benzodiazepines during pregnancy].
BACKGROUND
Due to the pharmacological characteristics of benzodiazepines, they have been use in a wide variety of disorders, as well as during pregnancy and labor. Benzodiazepine intake during early pregnancy may be teratogenic, and their intake during late pregnancy may be associated with neonatal withdrawal syndrome and 'floppy infant' syndrome.


METHODS
A hypotonic syndrome in twins secondary to the use of diazepam in the last month of pregnancy is described. Their neurological improvement occur in the first two weeks of life, in relation with the normalization in diazepam blood levels.


CONCLUSIONS
The list of possible diagnosis for floppines in newborn is extensive, and we must remember some drugs use during pregnancy. Diazepam show a rapid placental transfer with significant uptake of the drug; by this, high single doses and repeated and prolonged administration of benzodiazepines have to be avoided during pregnancy.
González de Dios
J
J
Departamento de Pediatría, Hospital Universitario San Juan, Universidad Miguel Hernández, Alicante, España.
Moya-Benavent
M
M
Carratalá-Marco
F
F
D001569:Benzodiazepines / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D009123:Muscle Hypotonia / Q000139:chemically induced* / Q000175:diagnosis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014427:Twins
D001569:Benzodiazepines