Enantiomeric purity determination of propranolol by capillary electrophoresis using dual cyclodextrins and a polyacrylamide-coated capillary.
The use of a chirally selective capillary electrophoresis method is reported for the enantioselective purity determination of propranolol drug substance. The method employed a combination of both charged and neutral cyclodextrin. An internally coated capillary was used to suppress electroosmotic flow and potential peak tailing. The method was capable of monitoring below 0.1% m/m of the undesired impurity. Acceptable validation data was also obtained for recovery, linearity, and for both short and long-term injection precision.
Assi
K A
KA
Pharmaceutical Chemistry, School of Pharmacy, University of Bradford, West Yorkshire, UK.
Clark
B J
BJ
Altria
K D
KD
D019075:Electrophoresis, Capillary / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D011433:Propranolol / Q000302:isolation & purification*; D013237:Stereoisomerism
D011433:Propranolol