title: Microbial hydroxylation of natural drimenic lactones.
abstract: Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3 beta-hydroxy derivatives. From isodrimenin, the known natural 7 alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université René Descartes-Paris V, France.
authors.forename: M
authors.initials: M
authors.lastname: Maurs
authors.forename: R
authors.initials: R
authors.lastname: Azerad
authors.forename: M
authors.initials: M
authors.lastname: Cortés
authors.forename: G
authors.initials: G
authors.lastname: Aranda
authors.forename: M B
authors.initials: MB
authors.lastname: Delahaye
authors.forename: L
authors.initials: L
authors.lastname: Ricard
mesh_terms: D018360:Crystallography, X-Ray; D005658:Fungi / Q000378:metabolism; D006900:Hydroxylation; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
chemical_list: D007783:Lactones