title: Application of several modified peak purity assays to real complex multicomponent mixtures by high-performance liquid chromatography with diode-array detection.
abstract: Simple to use interactive self-modelling mixture analysis (SIMPLISMA), orthogonal projection (OPA) and Needle Search (NS) approaches have been applied to the determination of a number of compounds present in a complex multicomponent system. None of these three approaches succeeded completely when they were tested using the whole data matrix. When OPA and NS were applied to three simpler submatrices, obtained by dividing the total data matrix, and where a smaller number of compounds were present, better performance was achieved.
authors.affiliation: Department of Hydrogeology and Analytical Chemistry, University of Almería, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Garrido Frenich
authors.forename: J R
authors.initials: JR
authors.lastname: Torres-Lapasió
authors.forename: K
authors.initials: K
authors.lastname: De Braekeleer
authors.forename: D L
authors.initials: DL
authors.lastname: Massart
authors.forename: J L
authors.initials: JL
authors.lastname: Martínez Vidal
authors.forename: M
authors.initials: M
authors.lastname: Martínez Galera
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet