Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).
Small-conductance, calcium-activated potassium channels contribute to the afterhyperpolarization in central neurons and other cell types. Because these channels regulate neuronal excitability, defects in their genes could cause excitability disorders. The human cDNA encoding one such channel, SK1 (KCNN1), was recently cloned. Here we describe the gene structure of KCNN1 and its localization by radiation hybrid mapping to chromosome 19p13.1.
Litt
M
M
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland OR (USA).
LaMorticella
D
D
Bond
C T
CT
Adelman
J P
JP
D000818:Animals; D001483:Base Sequence; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D007438:Introns / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D016133:Polymerase Chain Reaction; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D012689:Sequence Homology, Nucleic Acid; D051640:Small-Conductance Calcium-Activated Potassium Channels
C496894:KCNN1 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels