[The action of ADP ribose on the mechanical and bioelectrical activity of the frog heart].
In the frog isolated heart, cyclic perfusion of ADP-ribose induced a dose-dependent decrease in the heart rate and the contraction force, a decrease in the AP duration as well as in the rate of rise in the sinus node. It also shortened the atrial AP and exerted no significant effect upon multicellular ventricular preparations. In conditions of systemic administration in unanesthetised frogs, the ADP-ribose induced a reversible increase in the heart rate due, probably, to a sympathetic effect.
Sosulina
L Iu
LIu
M. V. Lomonossov State University, Moscow, Russia.
Sukhova
G S
GS
Chudnyĭ
M N
MN
Ashmarin
I P
IP
D000246:Adenosine Diphosphate Ribose / Q000494:pharmacology*; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects / Q000706:statistics & numerical data; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D011896:Rana temporaria; D012815:Signal Processing, Computer-Assisted; D018709:Statistics, Nonparametric
D000246:Adenosine Diphosphate Ribose; D000249:Adenosine Monophosphate