Esophageal aperistalsis following fundoplication in a patient with trisomy 21.
Gastrointestinal abnormalities are frequent in patients with Down syndrome (DS), gastroesophageal reflux (GER) being prominent among them. A 10-year-old boy with DS presented with progressive daily vomiting and an upper gastrointestinal study documenting reflux. A laparoscopic Nissen fundoplication was performed uneventfully. Postoperative inability to take solids was noted and a contrast study showed a tight gastroesophageal junction and poor peristalsis. Persistent symptoms were not alleviated by esophageal dilatation, despite a relaxing lower esophageal sphincter. Esophageal manometry documented complete esophageal aperistalsis. A percutaneous endoscopic gastrostomy was placed and the patient required long-term tube feeds. Esophageal aperistalsis is a rare condition in DS, likely superimposed on GER. Fundoplication may adversely affect the already abnormal esophageal motility in these children. Esophageal manometry preoperatively will identify motility disorders and assist in selecting the best management for these patients.
Bozinovski
J
J
Departments of Surgery and Medicine, Queen's University, Kingston, Ontario, Canada.
Poenaru
D
D
Paterson
W
W
Kamal
I
I
D002648:Child; D004314:Down Syndrome / Q000150:complications*; D015154:Esophageal Motility Disorders / Q000209:etiology*; D018662:Fundoplication / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008365:Manometry