title: Suppressive mechanism of gastric motility by whole-body vibration.
abstract: OBJECTIVE
  To investigate the mechanism of gastric motility suppression by exposure to whole-body vibration (WBV).
  
  
  METHODS
  The gastric motility was evaluated by electrogastrography (EGG) under food intake and autonomic nerve blocking agents in ten healthy volunteers. Sinusoidal vertical vibration with a frequency of 4 Hz (1.0 ms(-2) rms) was given to the subject for 10 min.
  
  
  RESULTS
  The amplitude of EGG wave and the power spectrum corresponding to the slow wave component was remarkably decreased by vibration exposure. Food intake enhanced the gastric motility about 2.5-fold in the power spectral density. During and after vibration exposure, the response mode was similar to those at fasting states. Under the influence of anticholinergic (scopolamine) and alpha-adrenergic blocking agents (prazosin), the power spectra were decreased. A further decrease was observed during vibration exposure. A beta-adrenergic blocking agent (propranolol) led to a marked increase in the amplitude of EGG and its power spectrum. With pretreatment by a beta-adrenergic blocking agent, however, vibration exposure reduced both of them.
  
  
  CONCLUSIONS
  These results suggest that short-term exposure to WBV can suppress the gastric myoelectric activity, the responses on which may be mediating by neurohumoral effects as well as the mechanical effect of WBV.
authors.affiliation: Department of Environmental Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan. tishitak@med.kurume-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ishitake
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: T
authors.initials: T
authors.lastname: Matoba
mesh_terms: D018674:Adrenergic Antagonists / Q000494:pharmacology; D000328:Adult; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004435:Eating / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D018709:Statistics, Nonparametric; D014732:Vibration / Q000009:adverse effects*
chemical_list: D018674:Adrenergic Antagonists; D018680:Cholinergic Antagonists