title: Reducing chorioretinal viral counts with intravitreal foscarnet injections in a rabbit model of Herpes simplex virus type-1 retinitis.
abstract: The efficacy of intravitreal foscarnet injections was evaluated in a rabbit model of Herpes simplex virus type-1 (HSV-1) retinitis. In untreated infected animals, viral titration revealed that the optic chiasm, vitreous and chorioretina were positive for HSV-1. On the other hand, foscarnet treatment significantly decreased the viral count in the chorioretina when compared to the untreated group. Immunolocalization of HSV in untreated infected animals clearly showed infected cells in the outer and inner layers of the retina and also in the ciliary body of the eye. Clinical examination by indirect ophthalmoscopy indicated an absence of optic nerve congestion and a lower level of vitritis in foscarnet treated animals compared to the untreated group. It is concluded that intravitreal injections of foscarnet reduced the viral titer in the chorioretina in a rabbit model of HSV-1 retinitis. This route of administration might be valuable for the treatment of CMV retinitis in AIDS patients with sight threatening lesions or intolerance to intravenous anti-CMV drugs.
authors.affiliation: Centre de Recherche en Infectiologie, Centre Hospitalier, Universitaire de Québec, Canada.
authors.forename: N J
authors.initials: NJ
authors.lastname: Morin
authors.forename: C
authors.initials: C
authors.lastname: Delorme
authors.forename: P
authors.initials: P
authors.lastname: Gourde
authors.forename: R F
authors.initials: RF
authors.lastname: Omar
authors.forename: A
authors.initials: A
authors.lastname: Désormeaux
authors.forename: M J
authors.initials: MJ
authors.lastname: Tremblay
authors.forename: D
authors.initials: D
authors.lastname: Beauchamp
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
authors.forename: M G
authors.initials: MG
authors.lastname: Bergeron
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002829:Choroid / Q000187:drug effects / Q000821:virology*; D017245:Foscarnet / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000188:drug therapy* / Q000473:pathology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D009887:Ophthalmoscopy; D009900:Optic Nerve / Q000473:pathology / Q000821:virology; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000821:virology*; D012173:Retinitis / Q000188:drug therapy* / Q000473:pathology / Q000821:virology
chemical_list: D017245:Foscarnet