A product of growth arrest-specific gene 6 modulates scavenger receptor expression in human vascular smooth muscle cells.
Although Gas6 is identified as a growth factor for vascular smooth muscle cells (VSMCs), its roles in these cells have not been clearly elucidated. To examine the role of Gas6 in atherosclerosis, we examined the effects of Gas6 on scavenger receptor family expression in VSMCs. Scavenger receptor class A, one of the scavenger receptor family members, was upregulated in VSMCs by Gas6. Furthermore, the atherogenic lipoprotein, oxidized LDL, induced Gas6 production in these cells. These results indicate that Gas6 plays an important role in foam cell formation in human VSMCs.
Murao
K
K
First Department of internal Medicine, Kagawa Medical University, Kagawa, Japan. mkoji@kms.ac.jp
Imachi
H
H
Sayo
Y
Y
Hosokawa
H
H
Sato
M
M
Ishida
T
T
Nakano
T
T
Kodama
T
T
Sasaguri
Y
Y
Takahara
J
J
D002460:Cell Line; D015870:Gene Expression; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL / Q000378:metabolism; D008565:Membrane Proteins; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000096:biosynthesis / Q000235:genetics; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000235:genetics; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D051122:Scavenger Receptors, Class B; D000099255:Growth Arrest-Specific Protein 6
D036341:Intercellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL; D008565:Membrane Proteins; D011506:Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D051122:Scavenger Receptors, Class B; D000099255:Growth Arrest-Specific Protein 6; C454739:Scarb1 protein, mouse; C032629:acetyl-LDL; C099252:oxidized low density lipoprotein