[The effect of selective m-cholinopositive substances on the antiparkinson activity of atropine].
The effect of the selectivity of cholinopositive compounds on atropin antiparkinsonian activity was compared in experiments on rats. The selectivity of the effect of two new synthesized cholinopositive compounds of the phenylcarbamate group was evaluated in preliminary experiments. It was determined by means of these compounds that stimulation of m1-cholinoceptors reduces while stimulation of m2-cholinoceptors has no effect on the ability of atropin to prevent haloperidol-induced catalepsy.
Khrabrova
A V
AV
Institute of Toxicology, Russian Federation Ministry of Public Health, St. Petersburg, Russia.
Kosmachev
A B
AB
Titkova
T A
TA
Chigarev
A G
AG
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001285:Atropine / Q000494:pharmacology* / Q000627:therapeutic use; D001555:Benzene Derivatives / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006220:Haloperidol; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects
D000978:Antiparkinson Agents; D001555:Benzene Derivatives; D002800:Cholinesterase Inhibitors; D011976:Receptors, Muscarinic; D001285:Atropine; D006220:Haloperidol