title: Paralysis of ventilated newborn babies does not influence resistance of the total respiratory system.
abstract: Paralysis with pancuronium bromide is used in newborn infants to facilitate ventilatory support during respiratory failure. Changes in lung mechanics have been attributed to paralysis. The aim of this study was to examine whether or not paralysis per se has an influence on the passive respiratory mechanics, resistance (Rrs) and compliance (Crs) of the respiratory system in newborn infants. In 30 infants with acute respiratory failure, Rrs was measured during paralysis with pancuronium bromide and after stopping pancuronium bromide (group A). Rrs was also measured in an additional 10 ventilated infants in a reversed fashion (group B): Rrs was measured first in nonparalysed infants and then they were paralysed, mainly for diagnostic procedures, and the Rrs measurement repeated. As Rrs is highly dependent on lung volume, several parameters, that depend directly on lung volume were recorded: inspiratory oxygen fraction (FI,O2), arterial oxygen tension/alveolar oxygen tension (a/A) ratio and volume above functional residual capacity (FRC). In group A, the Rrs was not different during (0.236+/-0.09 cmH2O x s x mL(-1)) and after (0.237+/-0.07 cmH2O x s x mL(-1)) paralysis. Also, in group B, Rrs did not change (0.207+/-0.046 versus 0.221+/-0.046 cm x s x mL(-1) without versus with pancuronium bromide). FI,O2, a/A ratio and volume above FRC remained constant during paralysis. These data demonstrate that paralysis does not influence the resistance of the total respiratory system in ventilated term and preterm infants when measured at comparable lung volumes.
authors.affiliation: Intensive Care Unit, Children's Hospital, University of Zurich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Burger
authors.forename: S
authors.initials: S
authors.lastname: Fanconi
authors.forename: B
authors.initials: B
authors.lastname: Simma
mesh_terms: D000208:Acute Disease; D000403:Airway Resistance / Q000187:drug effects*; D005260:Female; D005652:Functional Residual Capacity / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008170:Lung Compliance / Q000187:drug effects*; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents; D010100:Oxygen / Q000097:blood; D010197:Pancuronium; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000628:therapy*
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D010197:Pancuronium; D010100:Oxygen