title: Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation?
abstract: An increasing number of studies document the presence of protein kinases facing outwards at the cell surface of a diverse array of cells. These ecto-protein kinases phosphorylate cell-surface proteins and soluble extracellular substrates, and thus could affect many physiological processes involving cell-cell contacts, cellular differentiation and proliferation, ion fluxes and cellular activation. To date, only limited attention has been paid to exploring ecto-protein kinases as possible pharmacological targets. Here, the identification and physiological role of ecto-protein kinases in different biological systems is described; it is suggested that ecto-protein kinases are attractive and novel candidates for pharmacological manipulation under various (patho)physiological conditions.
authors.affiliation: Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO BOX 80082, 3508 TB Utrecht, Netherlands. F.A.M.Redegeld@Pharm.UU.NL
authors.forename: F A
authors.initials: FA
authors.lastname: Redegeld
authors.forename: C C
authors.initials: CC
authors.lastname: Caldwell
authors.forename: M V
authors.initials: MV
authors.lastname: Sitkovsky
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D006801:Humans; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors
chemical_list: D047428:Protein Kinase Inhibitors; D000255:Adenosine Triphosphate