title: Necrobiotic cutaneous T-cell lymphoma.
abstract: We report 3 patients with granulomatous cutaneous T-cell lymphoma (CTCL) who showed necrobiosis histologically with palisading granulomas. Although granulomatous change may be present in up to 4% of cases of CTCL, necrobiosis is rare. Misdiagnosis may occur if epidermotropism is minimal or if atypical cells are masked by the granulomatous infiltrate. T-cell receptor gene analysis confirmed the presence of clonal T-cell populations in lesional skin from all 3 cases.
authors.affiliation: St John's Institute of Dermatology, St Thomas's Hospital, London, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Woollons
authors.forename: A
authors.initials: A
authors.lastname: Darvay
authors.forename: S M
authors.initials: SM
authors.lastname: Khorshid
authors.forename: S
authors.initials: S
authors.lastname: Whittaker
authors.forename: R R
authors.initials: RR
authors.lastname: Jones
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000175:diagnosis; D017441:Necrobiotic Disorders / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*