title: Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors.
abstract: A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P1', P2', and P3' has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.
authors.affiliation: Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, 53706, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: J C
authors.initials: JC
authors.lastname: Houtman
authors.forename: D T
authors.initials: DT
authors.lastname: Witiak
authors.forename: J
authors.initials: J
authors.lastname: Seltzer
authors.forename: P J
authors.initials: PJ
authors.lastname: Bertics
authors.forename: C T
authors.initials: CT
authors.lastname: Lauhon
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D014508:Urea / Q000031:analogs & derivatives*
chemical_list: D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D014508:Urea