Low-dose cyclosporin for multiple colonic ulcers associated with mixed connective tissue disease.
This report describes a patient with multiple colonic ulcers and mixed connective tissue disease. The histological findings of the colonic lesions showed vasculitis with T-cell infiltration, and the peripheral T cells were frequently in the activated phase of the cell cycle. In this patient, low-dose cyclosporin treatment (2.5 mg/kg/day) inhibited the T-cell activation in the peripheral lymphocytes and was very effective in the gastrointestinal disorder, which might be related to T-cell activation. This case suggests the possibility that even low-dose cyclosporin can exert a great influence on peripheral T cells and directly inhibit T-cell activation, thereby improving symptoms related to T-cell activation.
Maeda
N
N
Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan.
Abe
S
S
Yoshizawa
T
T
Ogawa
K
K
Sekigawa
I
I
Iida
N
N
Eguchi
M
M
Matsumoto
M
M
Hashimoto
H
H
Hirose
S
S
D000328:Adult; D016516:CD4-CD8 Ratio; D003108:Colonic Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014456:Ulcer / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D014657:Vasculitis / Q000276:immunology / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine