Potentiation by 2-deoxy-D-glucose tetraacetate of the antitumoral action of 5-fluorouracil in mice inoculated with L1210 ascites-producing cells.
Ascites-producing tumoral cells of the L1210 line were inoculated to syngenic mice. The gain in body weight and survival time were measured in untreated animals and mice injected intraperitoneally 1, 5 and 9 days after the administration of the tumoral cells with 5-fluorouracil (20-200 microg/g body wt.) and/or 2-deoxy-D-glucose tetraacetate (75 or 1,350 microg/g body wt.). The two agents failed to affect adversely the growth of control mice not inoculated with the tumoral cells. 5-fluorouracil caused a dose-related decrease in the body weight gain caused by the occurrence of the tumoral ascites and a dose-related prolongation of survival time. Although 2-deoxy-D-glucose tetraacetate, when tested in the low dose of 75 microg/g body weight opposed the effect of 5-fluorouracil on survival time, a higher dose of the ester (1,350 microg/g body weight) potentiated the effect of 5-fluorouracil to both decrease body weight gain and increase survival time. It is proposed, therefore, that 2-deoxy-D-glucose tetraacetate could be used to increase the cytostatic action of classical chemotherapeutic agents in the treatment of neoplastic diseases.
Olivares
E
E
Laboratory of Experimental Medicine, Brussels Free University, B-1070 Brussels, Belgium.
Kadiata
M M
MM
Malaisse
W J
WJ
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology* / Q000627:therapeutic use; D001201:Ascites; D004357:Drug Synergism; D005472:Fluorouracil / Q000494:pharmacology* / Q000627:therapeutic use; D005947:Glucose / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology
C115456:2-deoxy-glucose tetraacetate; D000964:Antimetabolites, Antineoplastic; D005947:Glucose; D005472:Fluorouracil