F+ ion implantation induced cell attachment on intraocular lens.
Cell attachment on the polymethylmethacrylate (PMMA) intraocular lens (IOL) was studied by ion implantation. F+ ion implantation was performed at an energy of 80 keV with fluences ranging from 5 x 10(12) to 5 x 10(15) ions/cm2 at room temperature. The cell attachment tests gave interesting results in that the number of the platelets, the neutral granulocytes, and the macrophages adhering on the surface of the IOLs was reduced significantly after F+ ion implantation. The optimal fluence was about 3 x 10(14) to 4 x 10(14) ions/cm2. The hydrophobicity imparted to the surface was also monitored. At the same time, no appreciable change in the tensile strength and the optical transmittance of the implanted samples was observed. X-ray photoelectron spectroscopy (XPS) and fourier transfer infrared (FTIR) analysis showed that F+ ion implantation caused the cleavage of some pendants, the oxidation of the surface, and the formation of some new F-containing groups. These results were responsible for the cell attachment changes.
Li
D J
DJ
Department of Materials Science and Engineering, Tsinghua University, Beijing, People's Republic of China. dejunli@mail.tjnu.edu.cn
Cui
F Z
FZ
Gu
H Q
HQ
D001792:Blood Platelets / Q000502:physiology; D002448:Cell Adhesion; D004577:Electron Probe Microanalysis; D005461:Fluorine; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008264:Macrophages / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D019904:Polymethyl Methacrylate; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D013816:Thermodynamics
D005461:Fluorine; D019904:Polymethyl Methacrylate