title: [Bone marrow transplantation in the treatment of autoimmune diseases. ISAMAIR Group].
abstract: EXPERIMENTAL BASIS AND CLINICAL OBSERVATIONS: Remission of an autoimmune disease has been observed in certain patients after bone marrow allograft from a healthy donor. Autoimmune disease in the donor can also be transmitted to an unaffected recipient. These phenomena would be hematopoietic-dependent. BONE MARROW ALLOGRAFTS: Indications for the treatment of refractory autoimmune diseases are exceptional due to the related mortality even in patients without malignant hematologic disease. A NEW THERAPEUTIC CONCEPT: Therapeutic intensification, followed with autologous peripheral stem cell grafts, a procedure with a mortality below 3% in 1997, constitutes a therapeutic alternative in these difficult indication concerning severe refractory autoimmune diseases including: sclerodermia, vasculitis, lupus, inflammatory myositis, autoimmune cyopenia.
authors.affiliation: Service de Médecine interne, Hôpital Saint Louis, Paris.
authors.forename: D
authors.initials: D
authors.lastname: Farge
authors.forename: M
authors.initials: M
authors.lastname: Breban
authors.forename: L
authors.initials: L
authors.lastname: Guillevin
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: P
authors.initials: P
authors.lastname: Cherin
authors.forename: J
authors.initials: J
authors.lastname: Cosserat
authors.forename: D
authors.initials: D
authors.lastname: Sicard
authors.forename: P
authors.initials: P
authors.lastname: Ribaud
authors.forename: J P
authors.initials: JP
authors.lastname: Marolleau
authors.forename: D
authors.initials: D
authors.lastname: Bouscary
authors.forename: X
authors.initials: X
authors.lastname: Mariette
authors.forename: C
authors.initials: C
authors.lastname: Gisselbrecht
authors.forename: E
authors.initials: E
authors.lastname: Gluckman
mesh_terms: D001327:Autoimmune Diseases / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous