Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits.
OBJECTIVE
To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process.


METHODS
A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months.


RESULTS
Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation.


CONCLUSIONS
The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.
Kato
T
T
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Nakayasu
K
K
Hosoda
Y
Y
Watanabe
Y
Y
Kanai
A
A
D000818:Animals; D003094:Collagen / Q000032:analysis; D003315:Cornea / Q000737:chemistry / Q000503:physiopathology* / Q000601:surgery*; D007150:Immunohistochemistry; D020731:Keratomileusis, Laser In Situ; D011817:Rabbits; D013997:Time Factors; D014945:Wound Healing
D003094:Collagen