title: Design and synthesis of a novel series of HIV-1 protease inhibitors.
abstract: The synthesis and the SAR study of novel pseudo symmetric inhibitors of HIV-1 protease are described. Michael addition of amino acid derivatives to vinyl ketones was utilized to derive a potent (nM) series of HIV-1 protease inhibitors.
authors.affiliation: Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Takashiro
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ozawa
authors.forename: A
authors.initials: A
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors