title: Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents.
abstract: In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 microM and 300, respectively.
authors.affiliation: Department of Organic Chemistry, School of Pharmacy, Shanghai Medical University, People's Republic of China.
authors.forename: P
authors.initials: P
authors.lastname: Xia
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Xia
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zheng
authors.forename: L M
authors.initials: LM
authors.lastname: Cosentino
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D013256:Steroids