[Effect of presynaptic dopaminergic agonism on the immobility of mice in the forced swimming test].
Administration of 0.05 mg/kg (i.p.) of apomorphine (APO) or of the two dopamine (DA) lipoamides, DA steatamide (S-DA) or DA palmitamide (P-DA), at doses of 10 or 30 mg/kg (i.p.), induced an anti-immobility effect, in the forced swimming test in mice, of the same order as those of imipramime (30 mg/kg, i.p.). At the aforementioned doses APO, S-DA or P-DA could be acting on the dopaminergic autoreceptors and cause a decrease of the turnover and/or the release of the brain DA in the striatum. In contrast, DA linoleamide (L-DA), which has no action on the brain DA, did not exhibit anti-immobility effect. It is suggested that the decrease of turnover and/or release of the brain DA, induced by APO, S-DA or P-DA, could constitute a clue of the extent of the extrasynaptic action developed by these drugs whose antiglutamatergic incidence could cause the anti-immobility effect, observed with these derivatives, as well as their possible antidepressive action.
Vamvakidès
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A
Laboratoire de Pharmacologie expérimentale, Faculté de Médecine d'Athènes, Grèce.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D017661:Receptors, Presynaptic / Q000187:drug effects*; D013550:Swimming / Q000523:psychology
D000928:Antidepressive Agents; D018491:Dopamine Agonists; D011954:Receptors, Dopamine; D017661:Receptors, Presynaptic