Lactic dehydrogenase virus infection inhibits allergic eosinophil reaction and IL-5 gene expression in vivo.
The effects of lactic dehydrogenase virus (LDV) infection on allergic eosinophil reaction and IL-5 gene expression were studied. LDV infection suppressed antigen-induced eosinophil recruitment into the peritoneal cavity in sensitized mice. The elevation of IL-5 gene expression in the spleen and mesenteric lymph nodes 6 h after ovalbumin challenge was significantly suppressed in LDV-infected mice compared with uninfected (control) mice. The expression of the interferon-gamma and IL-2 genes in the spleen, but not in mesenteric lymph nodes, was significantly suppressed in LDV-infected mice compared with control mice. The present results suggest, that suppression of IL-5 gene expression by LDV infection may not be mediated by a mutual inhibitory mechanism between Th1 and Th2 cells.
Morimoto
M
M
Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan.
Iwata
H
H
Hayashi
T
T
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D018174:Arterivirus Infections / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004804:Eosinophils / Q000276:immunology* / Q000473:pathology; D015870:Gene Expression; D006967:Hypersensitivity / Q000276:immunology; D007371:Interferon-gamma / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015848:Interleukin-5 / Q000235:genetics*; D007772:Lactate dehydrogenase-elevating virus; D008198:Lymph Nodes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010529:Peritoneal Cavity / Q000473:pathology; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000941:Antigens; D017931:DNA Primers; D007376:Interleukin-2; D015848:Interleukin-5; D007371:Interferon-gamma; D010047:Ovalbumin