title: Implications of histological grade of tumour for the prognosis of radically resected periampullary adenocarcinoma.
abstract: OBJECTIVE
  To study the influence of histological grade of tumour on the prognosis of radically resected periampullary cancers.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Teaching hospital, Austria.
  
  
  METHODS
  156 patients (papilla of Vater, n = 34, head of the pancreas, n = 105, and distal common bile duct, n = 17) who underwent partial pancreaticoduodenectomy for periampullary adenocarcinoma between 1 January, 1967 and 31 December, 1996.
  
  
  METHODS
  The relation between grade of tumour and site, T and N classification, extramural growth, invasion of vessels and resection margins, tumour volume, and survival time.
  
  
  RESULTS
  Well differentiated lesions were significantly more common in the papilla of Vater (n = 15, 44%, p = 0.01) than in the pancreatic head or the common bile duct (n = 20, 19%, and n = 5, 29%, respectively). Only in ampullary lesions did the grade of tumour significantly affect the incidence of other histopathological risk factors (T p = 0.003; nodal status p = 0.01; extramural growth p = 0.0001; tumour volume p = 0.02) and survival time (p = 0.02); no significant correlations were found in cancers of the head of the pancreas or common bile duct.
  
  
  CONCLUSIONS
  There was a significant difference in the distribution of grade of tumour between the different sites of origin of resected periampullary cancers. Grade of tumour correlated with T and N classification, tumour volume, extramural growth, and survival only in ampullary lesions.
authors.affiliation: Department of Surgery, Kaiser Franz Josef Hospital Vienna, Austria.
authors.forename: F J
authors.initials: FJ
authors.lastname: Sellner
authors.forename: F M
authors.initials: FM
authors.lastname: Riegler
authors.forename: E
authors.initials: E
authors.lastname: Machacek
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D014670:Ampulla of Vater / Q000473:pathology; D003135:Common Bile Duct / Q000473:pathology; D003138:Common Bile Duct Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D011379:Prognosis; D016019:Survival Analysis