title: Low serum C3, leukopenia, and thrombocytopenia: unusual features of henoch-schonlein purpura.
abstract: Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP.
authors.affiliation: Nephrology Clinic and Dialysis Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel. ikrause@post.tau.ac.il
authors.forename: I
authors.initials: I
authors.lastname: Krause
authors.forename: B Z
authors.initials: BZ
authors.lastname: Garty
authors.forename: M
authors.initials: M
authors.lastname: Davidovits
authors.forename: R
authors.initials: R
authors.lastname: Cleper
authors.forename: H
authors.initials: H
authors.lastname: Tamary
authors.forename: E
authors.initials: E
authors.lastname: Rosenmann
authors.forename: B
authors.initials: B
authors.lastname: Eisenstein
mesh_terms: D001707:Biopsy, Needle; D002648:Child; D015932:Complement C3c / Q000032:analysis*; D018450:Disease Progression; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis*; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D006435:Renal Dialysis; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D015932:Complement C3c