Natural Product Synthesis on Polymeric Supports-Synthesis and Biological Evaluation of an Indolactam Library.
Potent activators of protein kinase C in fibroblasts: This property was determined for several indolactam V analogues (1) with a new cell-based assay system. This tumor-promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.
Meseguer
B
Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Strasse 11, D-44227 Dortmund (Germany).
Alonso-Díaz
D
Griebenow
N
Herget
T
Waldmann
H