[Invasive aspergillosis sinusitis in patients infected by the human immunodeficiency virus].
Invasive aspergillus sinusitis invasive is a rare, life threatening infection observed in immunocompromised patients. We report three cases of patients with AIDS. Diagnosis was based on surgical biopsy specimen performed on patients with unilateral sinusitis with facial pain and osteolysis on CT scanning, associated in one patient with neurological disorders. One patient with frontal sinusitis and meningeal involvement died despite therapy. One patient with limited maxillary sinusitis who underwent surgical satisfactory resection and antifungal therapy was successfully treated without relapse 12 months later. One patient with orbital and cavernous sinus extension of ethmoiditis was successfully cured with antifungal therapy by itraconazole. Our results confirm the necessity of early diagnosis when clinical and CTscanning are suggestive and the curability of aspergillus sinusitis.
Barry
B
B
Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Paris.
Bouchaud
O
O
Vittecoq
D
D
Minozzi
C
C
Coulaud
J P
JP
Gehanno
P
P
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects; D001228:Aspergillosis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000473:pathology / Q000601:surgery; D012852:Sinusitis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D017964:Itraconazole