Rheological characterization of microcrystalline cellulose and silicified microcrystalline cellulose wet masses using a mixer torque rheometer.
The rheological properties of silicified microcrystalline cellulose (Prosolv 50) were compared with those of standard grades of microcrystalline cellulose (Emcocel 50 and Avicel PH 101). Cellulose samples were analyzed using nitrogen adsorption together with particle size, flowability, density and swelling volume studies. The rheological behaviour of the wet powder masses was studied as a function of mixing time using a mixer torque rheometer (MTR). Silicified microcrystalline cellulose exhibited improved flow characteristics and increased specific surface area compared to standard microcrystalline cellulose grades. Although the silicification process affected the swelling properties and, furthermore, the mixing kinetics of microcrystalline cellulose, the source of the microcrystalline cellulose had a stronger influence than silicification on the liquid requirement at peak torque.
Luukkonen
P
P
Pharmaceutical Technology Division, Department of Pharmacy, University of Helsinki, P.O. Box 56, Helsinki, Finland. pirjo.luukkonen@helsinki.fi
Schaefer
T
T
Hellén
L
L
Juppo
A M
AM
Yliruusi
J
J
D002482:Cellulose / Q000737:chemistry*; D003460:Crystallization; D004339:Drug Compounding; D010316:Particle Size; D016062:Porosity; D011208:Powders; D012212:Rheology; D012822:Silicon Dioxide / Q000737:chemistry*; D019415:Torque; D014867:Water / Q000737:chemistry; D017155:Wettability
D011208:Powders; D014867:Water; D012822:Silicon Dioxide; D002482:Cellulose