title: Nuclear proliferation in syncytia during avian reovirus replication.
abstract: Cultured chick embryonic fibroblasts formed syncytia after infection with avian reovirus (ARV) strain 58-132. Mitotic figures were occasionally observed within the syncytia. In addition, many nuclei in the syncytia incorporated 5-bromo-2'-deoxyuridine (BrdU), a DNA replication marker, indicating that they were in the S-phase of the cell cycle. These observations suggested that the nuclei within ARV-induced syncytia originated from nuclear endomitosis without cell division, as well as from cell fusion.
authors.affiliation: Department of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University, Sakai, Japan. ytsuka@jyui.vet.osakafu-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Kotani
authors.forename: K
authors.initials: K
authors.lastname: Kohama
authors.forename: S
authors.initials: S
authors.lastname: Sakuma
authors.forename: F
authors.initials: F
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D001717:Birds / Q000821:virology; D002467:Cell Nucleus / Q000000981:diagnostic imaging; D002642:Chick Embryo; D005347:Fibroblasts / Q000000981:diagnostic imaging / Q000821:virology; D015726:Giant Cells / Q000821:virology*; D008938:Mitosis; D018165:Orthoreovirus / Q000502:physiology*; D014463:Ultrasonography; D014779:Virus Replication