Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome. GRAID Research Group. Group for Research on Auto-Immune Disorders.
OBJECTIVE
To investigate the putative involvement of poly(ADP-ribose) polymerase (PARP) alleles in systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).


METHODS
This study of French Caucasians included 171 unrelated patients with SLE, 88 unrelated patients with primary APS, and 193 ethnically matched healthy controls. The SLE group comprised 89 patients with sporadic SLE and 82 patients with familial SLE. Patients' and controls' DNA were genotyped for the various alleles of a polymorphic CA dinucleotide repeat located within the promoter region of PARP.


RESULTS
No statistically significant difference was observed for the distribution of PARP alleles between the healthy control group and each patient group or the pooled SLE patient group.


CONCLUSIONS
The study findings strongly suggest that these alleles do not influence susceptibility to SLE or primary APS in French Caucasians.
Delrieu
O
O
INSERM U25, Faculté de Médecine Necker, Paris, France.
Michel
M
M
Francès
C
C
Meyer
O
O
Michel
C
C
Wittke
F
F
Crassard
I
I
Bach
J F
JF
Tournier-Lasserve
E
E
Piette
J C
JC
D000483:Alleles; D016736:Antiphospholipid Syndrome / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics; D008297:Male; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics*; D044465:White People
D011065:Poly(ADP-ribose) Polymerases