Microbial hydroxylation of natural drimenic lactones.
Incubation of confertifolin and isodrimenin with Mucor plumbeus, Aspergillus niger or Rhizopus arrhizus gave in good yields the corresponding 3 beta-hydroxy derivatives. From isodrimenin, the known natural 7 alpha-hydroxy derivative (futronolide) was also obtained and its structure was definitely established by X-ray crystallographic study of its acetate derivative.
Maurs
M
M
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université René Descartes-Paris V, France.
Azerad
R
R
Cortés
M
M
Aranda
G
G
Delahaye
M B
MB
Ricard
L
L
D018360:Crystallography, X-Ray; D005658:Fungi / Q000378:metabolism; D006900:Hydroxylation; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure
D007783:Lactones