An introduction to the pathophysiology of osteoarthritis.
Osteoarthritis involves the degeneration of articular cartilage together with changes in subchondral bone and limited intra-articular inflammation. In this chapter these changes are reviewed at the tissue, cell and molecular levels to reveal the complexity of a process which involves multiple changes in joint structure and turnover.
Poole
A R
AR
Joint Diseases Laboratory, Shriners Hospitals for Children and Division of Surgical Research, Department of Surgery, McGill University 1529 Cedar Avenue, Montreal, Quebec H3G 1A6 Canada. rpoole@shriners.mcgill.ca
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D016723:Bone Remodeling; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology; D002358:Cartilage, Articular / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005109:Extracellular Matrix / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008666:Metalloendopeptidases / Q000378:metabolism; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*
D015415:Biomarkers; D008666:Metalloendopeptidases