Stimulus properties of the selective 5-HT reuptake inhibitor fluvoxamine in conditioned taste aversion procedures.
Previous attempts to train pigeons and rats to discriminate between the antidepressant fluvoxamine and its vehicle as assessed in a drug discrimination paradigm have been without success. The present experiments were, therefore, designed to assess in a conditioned taste aversion procedure (CTA) whether or not fluvoxamine possesses stimulus properties. Rats were exposed to a conditioned taste aversion (CTA) procedure. In Experiment I, subjects were given 15 mg/kg fluvoxamine p.o. or vehicle after drinking a novel tasting saccharin solution. In Experiment II, a comparison was made between the effects of 15 mg/kg fluvoxamine i.p., 30 mg/kg fluvoxamine i.p., NaCl, and lithium chloride (LiCl). In Experiment III, subjects were treated with either 10 mg/kg fluoxetine i.p., 30 mg/kg fluvoxamine i.p., or LiCl. CTA was observed after treatment with LiCl, but never after treatment with fluvoxamine or fluoxetine, suggesting that fluvoxamine does not have clear stimulus properties, which can serve as a discriminative stimulus in operant procedures. In a crossfamiliarization CTA procedure in mice, however, fluvoxamine elicited a reliable CTA, suggesting that under certain conditions (species, dose?) selective serotonin reuptake inhibitors (SSRIs) may lead to certain discriminable effects. It is as yet unclear why SSRIs apparently produce such weak and species or situation-dependent discriminable effects.
Olivier
B
B
Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences, Faculty of Pharmacy, Utrecht University, The Netherlands.
Gommans
J
J
van der Gugten
J
J
Bouwknecht
J A
JA
Herremans
A H
AH
Patty
T
T
Hijzen
T H
TH
D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D016666:Fluvoxamine / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D017208:Rats, Wistar; D012439:Saccharin / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013549:Sweetening Agents / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*
D018692:Antimanic Agents; D016666:Fluvoxamine; D005947:Glucose; D018021:Lithium Chloride; D012439:Saccharin; D017367:Selective Serotonin Reuptake Inhibitors; D013549:Sweetening Agents