title: [Clinical analysis of patients with bacterial meningitis in childhood and reevaluation of rapid antigen detection methods].
abstract: Twenty-eight cases of bacterial meningitis during the recent ten years were analyzed retrospectively, and the following results were obtained. 1. Pathogens were as follows; H. influenzae 13 (46.4%), S. pneumoniae 8 (28.6%), S. agalactiae 4 (14.3%), E. coli 2 (7.1%), and L. monocytogenes 1 case (3.6%). 2. Twelve out of the thirteen H. influenzae cases were caused by serotype b (Hib), and 2 strains were beta-lactamase producer. Fifty percent of the S. pneumoniae cases were caused by penicillin-resistant strains. And all these resistant strains belonged to serotype 19 or 23. 3. Underlying diseases related to the onset of meningitis were found in 46% of the cases, and these consisted of CNS shunt operated 5, asplenia or polysplenia 2, Mondini's anomaly 1, sacral dermal sinus 1, and neonate 4 cases. 4. Prognosis of these cases were three deaths, four with neurologic sequelae, and twenty-one complete recoveries. 5. On admission, 85% (17/20) of the cases were diagnosed correctly by the rapid antigen detection. Sensitivity and specificity of the rapid antigen detection by using latex particle agglutination is 90% and 100% in the Hib cases, and 83% and 100% in the S. pneumoniae cases respectively. Moreover, the bacteriologically unknown 2 cases caused by parenteral partial treatment were also diagnosed by the detection of antigen in concentrated urine.
authors.affiliation: Division of Infectious Diseases, Chiba Children's Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Kuroki
authors.forename: H
authors.initials: H
authors.lastname: Ohshima
authors.forename: T
authors.initials: T
authors.lastname: Sugioka
authors.forename: N
authors.initials: N
authors.lastname: Ishiwada
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: J
authors.initials: J
authors.lastname: Aizawa
authors.forename: K
authors.initials: K
authors.lastname: Ohkusu
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000382:microbiology* / Q000401:mortality; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012703:Serotyping
chemical_list: D000942:Antigens, Bacterial