title: Gender-related differences in polyamine oxidase activity in rat tissues.
abstract: Variations in level of polyamines and their related enzymes are frequently observed in response to some treatments which affect in a different way male and female. The possibility of a gender-related difference in the oxidation of polyamines was investigated in rats by measuring the activity of polyamine oxidase, a ubiquitous enzyme of vertebrate tissues, which transforms spermine into spermidine and spermidine into putrescine. The study was carried out on thymus, spleen, kidney and liver of young rats of both sexes, and female rats showed a lower polyamine oxidase activity than male rats in all the tissues. We also found higher values of spermidine acetylation in female than male rats in thymus and liver. Owing to these gender-related differences, a higher spermidine N-acetyltransferase/polyamine oxidase ratio was found in female than in male rats. A second gender-related difference was a higher spermidine/spermine ratio in female than in male, the only exception being the thymus. These basal differences possibly account for the gender-related differences of polyamine metabolic enzyme activities in response to some treatments, including drugs or hormones.
authors.affiliation: Centro di Studio sulla Patologia Cellulare, C.N.R., Milano, Italy. mafe@imiucca.csi.unimi.it
authors.forename: M E
authors.initials: ME
authors.lastname: Ferioli
authors.forename: O
authors.initials: O
authors.lastname: Pinotti
authors.forename: L
authors.initials: L
authors.lastname: Pirona
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D005260:Female; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013154:Spleen / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology; D014018:Tissue Distribution; D000097667:Polyamine Oxidase; D000099228:Diamine N-Acetyltransferase
chemical_list: D000123:Acetyltransferases; D000596:Amino Acids; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D000097667:Polyamine Oxidase; D000099228:Diamine N-Acetyltransferase