title: 2-Naphthylcarbapenems: broad spectrum antibiotics with enhanced potency against MRSA.
abstract: A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum of gram-negative activity.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Greenlee
authors.forename: F
authors.initials: F
authors.lastname: DiNinno
authors.forename: J J
authors.initials: JJ
authors.lastname: Herrmann
authors.forename: C
authors.initials: C
authors.lastname: Jaworsky
authors.forename: D A
authors.initials: DA
authors.lastname: Muthard
authors.forename: T N
authors.initials: TN
authors.lastname: Salzmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D004150:Dipeptidases / Q000378:metabolism; D016106:Methicillin Resistance; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D009281:Naphthalenes; D004150:Dipeptidases; C038937:dipeptidase