Comparison of nitroglycerin lingual spray and sublingual tablet on time of onset and duration of brachial artery vasodilation in normal subjects.
This study compared the rapidity of onset, the magnitude, and the duration of action of 2 short-acting nitroglycerin preparations using high-resolution brachial ultrasound. Both sublingual tablet and lingual spray formulations caused maximal vasodilation at 3 minutes; however, the spray provided faster (at 2 minutes), greater, and more prolonged (15 minutes) vasodilation than the tablet.
Ducharme
A
A
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
Dupuis
J
J
McNicoll
S
S
Harel
F
F
Tardif
J C
JC
D000284:Administration, Oral; D000286:Administration, Sublingual; D000328:Adult; D000336:Aerosols; D000704:Analysis of Variance; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage*; D014463:Ultrasonography; D014665:Vasodilator Agents / Q000008:administration & dosage*
D000336:Aerosols; D014665:Vasodilator Agents; D005996:Nitroglycerin