[Usefulness of visualized highly sensitive new chemical dosimeter: application to blood irradiation].
In the prophylaxis of post-transfusion GVHD, it is recommended to irradiate blood components with an absorbed dose ranging from 15 Gy to 50 Gy. We applied a new chemical dosimeter to measure absorbed dose for blood irradiation. This system is composed of diphenyliodoniumchloride (DICI) as an oxidizer and crystal violet lactone as a pH indicator. Protons are released from DICI after irradiation. The maximum absorption wavelength of this indicator is 610 nm, and absorbance is linearly related with a given dose from 1 to 50 Gy. Coloration is stable for at least 2 weeks when stored in the dark at 4 degrees C. This system may be used as a chemical dosimeter for blood irradiation.
Sekine
H
H
Department of Radiology, Jikei University School of Medicine.
Takiue
M
M
Yoshizawa
Y
Y
Natake
T
T
Kanehira
C
C
D001769:Blood / Q000528:radiation effects*; D001803:Blood Transfusion; D005720:Gamma Rays; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D011874:Radiometry; D012680:Sensitivity and Specificity