title: Right ventricular systolic function and ventricular interaction during acute embolisation of the left anterior descending coronary artery in sheep.
abstract: OBJECTIVE
  Regional LV ischemia involving the septum affects LV systolic function and geometry. We investigated the effects of these changes on RV function and geometry.
  
  
  METHODS
  In six closed-chest sheep end-systolic pressure-volume relationships (ESPVRs) were constructed from ventricular volumes, measured with magnetic resonance imaging (MRI) and matching intraventricular pressures, before and after selective embolisation of the left anterior descending coronary artery (LAD). The extent of myocardial ischemia was assessed post-mortem by coronary perfusion with Evans-Blue. Alterations in septal geometry were studied by measuring the curvature, segmental length and thickness of the septum in two midventricular (short-axis) MRI slices before and during ischemia. From these data, changes in LV and RV free wall segmental lengths were calculated.
  
  
  RESULTS
  Selective embolisation of the LAD resulted in left ventricular ischemia (15 +/- 2.1% of the total LV) with 23% of the septum involved. Stroke volume did not change significantly, while LV systolic pressure decreased by 24 mmHg (p < 0.05). Although RV systolic function decreased to a significantly lesser extent than LV function (p < 0.01), systolic function of both ventricles diminished significantly as indicated by substantial rightward shifts of the ESPVRs: 121% for LV and 41% for RV (both p < 0.01). At mid-ventricular level and end-systole, the septum showed significant increases in its radius of curvature and segmental length (both p < 0.05), and a significant wall thinning (p < 0.01). Calculated end-systolic lengths of LV and RV free walls also increased, by 57 and 14% respectively.
  
  
  CONCLUSIONS
  LAD embolisation not only results in a significantly diminished LV systolic function but also causes RV systolic function to decline significantly. Regional dysfunction by necessity entails global dysfunction as well. Analysis of ventricular geometry reveals that both the septum and the RV free wall increase their length, which plays an important role in the pathophysiology of diminished RV systolic function concomitant with reduced LV function.
authors.affiliation: Leiden University Medical Centre, Department of Cardiology, Leiden, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Jerzewski
authors.forename: P
authors.initials: P
authors.lastname: Steendijk
authors.forename: P M
authors.initials: PM
authors.lastname: Pattynama
authors.forename: B P
authors.initials: BP
authors.lastname: Leeuwenburgh
authors.forename: A
authors.initials: A
authors.lastname: de Roos
authors.forename: J
authors.initials: J
authors.lastname: Baan
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology*; D003331:Coronary Vessels; D004617:Embolism; D006439:Hemodynamics; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D009206:Myocardium / Q000473:pathology; D012756:Sheep; D013599:Systole; D018497:Ventricular Dysfunction, Right / Q000473:pathology / Q000503:physiopathology*