Gingival hemorrhage, myelodysplastic syndromes, and acute myeloid leukemia. A case report.
Myelodysplasia syndrome (MDS) presenting as spontaneous gingival hemorrhage is described. Gingival hemorrhage is recognized as a symptom of MDS, a rare group of potentially fatal hematological disorders, but it has not previously been documented as a presenting sign. The diagnostic pitfalls are discussed with the case, and the need for careful interpretation of laboratory findings in conjunction with clinical signs is emphasized. Finally, the MDSs are defined, classified and discussed with respect to their relevance to the clinical periodontist, from a diagnostic, therapeutic, and management standpoint.
Chapple
I L
IL
Tissue Injury/Repair Research Group, Birmingham's School of Dentistry, The University of Birmingham, UK.
Saxby
M S
MS
Murray
J A
JA
D000208:Acute Disease; D001707:Biopsy, Needle; D001854:Bone Marrow Cells / Q000473:pathology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005884:Gingival Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy; D006490:Hemostatics / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis* / Q000188:drug therapy; D012008:Recurrence; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000009:adverse effects
D006490:Hemostatics; D014148:Tranexamic Acid