title: Pilot study on the effect of a mouthrinse containing silver zeolite on plaque formation.
abstract: A double-blind cross-over study was performed to evaluate the inhibitory activity of silver zeolite (SZ) mouthrinse on plaque formation. Eleven dental students participated in this study. SZ mouthrinse was prepared by suspending SZ powder into phosphate-buffered saline (PBS) at a concentration of 3% (w/w). Type-A zeolite was used as a placebo. Before the experiment, the subjects were rendered plaque-free by professional prophylaxis. They then suspended any oral hygiene for five days, during which time they rinsed with either SZ or type-A zeolite mouthrinse twice a day. SZ significantly reduced plaque formation compared to the placebo (p < 0.05), suggesting that silver ions released from the SZ inhibited plaque formation.
authors.affiliation: Department of Preventive Dentistry, Hiroshima University School of Dentistry, Japan. mark@ipc.hiroshima-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Morishita
authors.forename: M
authors.initials: M
authors.lastname: Miyagi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Tsuruda
authors.forename: K
authors.initials: K
authors.lastname: Kawahara
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000188:drug therapy / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007477:Ions; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use*; D010865:Pilot Projects; D012834:Silver / Q000627:therapeutic use*; D018030:Silver Compounds; D018709:Statistics, Nonparametric; D017641:Zeolites / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D007477:Ions; D009067:Mouthwashes; D018030:Silver Compounds; D017641:Zeolites; D012834:Silver