title: [Dose the administration of low-dose aprotinin contribute to an anti-inflammatory effect in coronary artery bypass grafting?].
abstract: A study was conducted to determine whether the administration of low-dose aprotinin contributed to an anti-inflammatory effect in coronary artery bypass grafting. Levels of the inflammatory cytokines; IL-6, IL-8, and GEL, were measured before and after cardiopulmonary bypass, then 1, 3 and 6 days after coronary artery bypass grafting, in a group of patients given aprotinin (n = 7) and a control group (n = 15). A comparison of the levels of all these inflammatory cytokines between the two groups revealed no significant difference at any time point. This indicates, that low-dose aprotinin did not contribute to an anti-inflammatory effect in coronary artery bypass grafting.
authors.affiliation: First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Shirasawa
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: H
authors.initials: H
authors.lastname: Gohra
authors.forename: T
authors.initials: T
authors.lastname: Katoch
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimura
authors.forename: N
authors.initials: N
authors.lastname: Zempo
authors.forename: K
authors.initials: K
authors.lastname: Esato
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D007611:Aprotinin / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D019272:Leukocyte Elastase / Q000097:blood; D008875:Middle Aged
chemical_list: D000893:Anti-Inflammatory Agents; D015850:Interleukin-6; D016209:Interleukin-8; D007611:Aprotinin; D019272:Leukocyte Elastase