Congenital acute megakaryoblastic leukemia (M7) with chromosomal t(1;22)(p13;q13) translocation in a set of identical twins.
Chromosomal translocations at t(1;22)(p13;q13) have been reported to occur in a number of infants with acute megakaryoblastic leukemia. A set of female twins with acute megakaryoblastic leukemia are reported with this unique translocation of 1p13 to 22q13. The twins presented at 2 months of age with fever and poor feeding and subsequently developed progressive hepatosplenomegaly. One twin died before treatment could be started; the other became septicemic 5 days after initiation of chemotherapy and eventually died.
Ng
K C
KC
Department of Paediatrics, KK Women's & Children's Hospital, Singapore, Republic of Singapore.
Tan
A M
AM
Chong
Y Y
YY
Lau
L C
LC
Lou
J
J
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D004200:Diseases in Twins / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006529:Hepatomegaly; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D013163:Splenomegaly; D014178:Translocation, Genetic; D014430:Twins, Monozygotic
D000970:Antineoplastic Agents