title: [Vitamin B6].
abstract: 1934, vitamin B6 was discovered by P. György. Vitamin B6 consists of 3 closely related pyrimidine derivatives: pyridoxine, pyridoxal and pyridoxamine and their phosphate esters. The tumor-specific compound has been recently found to be as a new B6 derivatives. The active form of vitamin B6 is pyridoxal phosphate (PLP) which is produced by multi-metabolizing enzymes including pyridoxine kinase and PNP/PMP oxidase. PLP functions as the coenzymes of many enzymes which catalyze biochemical reactions such as transamination and decarboxylation. A novel physiological function of PLP which is the negative modulator of the steroid-dependent gene expression and the albumin gene expression has been also revealed.
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, Kagoshima University.
authors.forename: T
authors.initials: T
authors.lastname: Oka
mesh_terms: D000818:Animals; D011736:Pyridoxine / Q000737:chemistry / Q000378:metabolism / Q000502:physiology
chemical_list: D011736:Pyridoxine