Structure-function analysis of the feline herpesvirus virulence factors gE and gI.
The biosynthesis and function of the gE-gI complex of feline herpesvirus (FHV) was studied by heterologous expression of the cloned genes in the vaccinia virus-based vTF7-3 expression system and by analysis of FHV recombinants. This work has led to the identification of domains in gI involved in complex formation with gE, and to a model for the disulfide-bonded structure of gI. The effects of mutations in gI on gE-gI-dependent cell-to-cell transmission are discussed.
Mijnes
J D
JD
Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, The Netherlands.
de Groot
R J
RJ
D000818:Animals; D002415:Cats; D002450:Cell Communication; D006564:Herpesviridae / Q000472:pathogenicity*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D014759:Viral Envelope Proteins / Q000235:genetics / Q000502:physiology*
D008565:Membrane Proteins; D014759:Viral Envelope Proteins