Phenyl N-tert-butylnitrone provides protection from endotoxin shock through amplified production of the anti-inflammatory cytokine interleukin-10.
Kotake
Y
Y
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA. yashige-kotake@ouhsc.edu
Sang
H
H
Wallis
G L
GL
Stewart
C A
CA
D000818:Animals; D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D007375:Interleukin-1 / Q000235:genetics; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000276:immunology*; D009589:Nitrogen Oxides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D012016:Reference Values; D012772:Shock, Septic / Q000276:immunology* / Q000517:prevention & control*; D014158:Transcription, Genetic / Q000187:drug effects*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D007375:Interleukin-1; D008070:Lipopolysaccharides; D009589:Nitrogen Oxides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; C029217:phenyl-N-tert-butylnitrone