Differences in lung bioavailability between different propellants for fluticasone propionate.
The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.
Wilson
A M
AM
Sims
E J
EJ
Orr
L C
LC
Lipworth
B J
BJ
D000328:Adult; D000335:Aerosol Propellants; D000730:Androstadienes / Q000493:pharmacokinetics*; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D017402:Chlorofluorocarbons; D004305:Dose-Response Relationship, Drug; D000068298:Fluticasone; D006801:Humans; D006845:Hydrocarbons, Fluorinated; D006854:Hydrocortisone / Q000652:urine; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D016037:Single-Blind Method; D005466:Fluorocarbons
D000335:Aerosol Propellants; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D017402:Chlorofluorocarbons; D000068298:Fluticasone; D006845:Hydrocarbons, Fluorinated; D006854:Hydrocortisone; C094049:apaflurane; D005466:Fluorocarbons