title: Formaldehyde generation by N-demethylation.
abstract: Microsomal oxidation of exogenic compounds yields efferent metabolites with small molecular size. N-demethylation results in formaldehyde generation in addition to the nor-compound. Interesting changes in the level of formaldehyde elimination were observed after a single dose of either ( )-deprenyl or (+)-deprenyl. Urine elimination of the generated formaldehyde was determined using thin-layer chromatography after derivatization with dimedone.
authors.affiliation: Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary. KalHub@net.sote.hu
authors.forename: H
authors.initials: H
authors.lastname: Kalász
authors.forename: M
authors.initials: M
authors.lastname: Báthori
authors.forename: E
authors.initials: E
authors.lastname: Tyihák
mesh_terms: D005557:Formaldehyde / Q000652:urine*; D006801:Humans; D008297:Male; D008745:Methylation; D012642:Selegiline / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D005557:Formaldehyde; D012642:Selegiline