title: [Molecular and cellular determinants of arterial stiffness: role of cell-matrix connections].
abstract: Increased large artery stiffness is believed to be a cardiovascular risk factor independent from mean arterial pressure. The mechanical properties of large arteries depend not only on the amounts of their main constituents (elastin, collagen, and smooth muscle cells) but also on the spatial organization and mechanical interactions among these components. These interactions may be mediated by extracellular matrix adhesion proteins and their membrane receptors or integrins. From a mechanical viewpoint, a key element may be the dense plaque, which is composed of cytoskeletal proteins linked to matrix proteins via membrane integrin receptors. Integrin expression in normal and diseased blood vessels is currently the focus of active research. In humans, hypertension-related arterial hypertrophy is not associated with an increase in intrinsic arterial wall stiffness. Aortic fibronectin expression is increased in spontaneously hypertensive rats (SHRs). By increasing cell-matrix anchoring, fibronectin may contribute to protect arterial wall components from the increased mechanical loads associated with hypertension. In atherosclerosis, the increase in cell-matrix anchoring plays a key role in preventing atheroma plaque rupture. To determine the exact role of adhesion molecules in arterial stiffness, there is a need for studies involving use of specific anti-integrin agents and of transgenic animal models.
authors.affiliation: Service de Pharmacie, Hôtel-Dieu, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Bézie
authors.forename: J M
authors.initials: JM
authors.lastname: Daniel-Lamazière
authors.forename: G
authors.initials: G
authors.lastname: Gabella
authors.forename: I
authors.initials: I
authors.lastname: Koffi
authors.forename: S
authors.initials: S
authors.lastname: Laurent
authors.forename: P
authors.initials: P
authors.lastname: Lacolley
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000473:pathology*; D006801:Humans; D012307:Risk Factors