title: Cellular toxicity of N-substituted 2,2'-dicarboxamidodiphenyldisulphides with high antimicrobial activity.
abstract: In the present paper we evaluate the cellular toxicity of some N-substituted 2,2'-dicarboxamidodiphenyldisulphides with high antimicrobial activities, in view of their potential application in humans or animals. The toxicological studies have been conducted in the murine cell line of 3T3 fibroblasts as eucaryotic cellular model. Our results have allowed the identification of a series of derivatives exhibiting antimicrobial activity and low cellular toxicity. Structure-cytotoxic activity relationships are also discussed.
authors.affiliation: Institute of Pharmacology and Pharmacognosy, University of Parma, Parma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Favari
authors.forename: E
authors.initials: E
authors.lastname: Bernardini
authors.forename: F
authors.initials: F
authors.lastname: Bernini
authors.forename: P
authors.initials: P
authors.lastname: Mazza
authors.forename: F
authors.initials: F
authors.lastname: Zani
mesh_terms: D016475:3T3 Cells; D000577:Amides / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000494:pharmacology / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D051379:Mice; D013329:Structure-Activity Relationship; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000577:Amides; D000890:Anti-Infective Agents; D004220:Disulfides; D013778:Tetrazolium Salts; D013844:Thiazoles; D007770:L-Lactate Dehydrogenase; C022616:thiazolyl blue