[Experimental investigation of 2,2'-diamino-1,1'-dinaphthyl in rats and mice].
Carcinogenicity of 2,2'-diamino-1,1'-dinaphthyl has been investigated in chronic experiments on LIO rats and CC57 mice. Single doses of 20 mg were given to rats and 1-5 mg--mice. Subcutaneous injections were followed by sarcoma development on injection site in 90% of male rats and 31%--females. Female rats (46%) also revealed multiple benign tumors of the mammary gland. Such tumors alone were detected in females (44%) receiving the agent with feed. All mouse males and 71-100% of females developed hepato- and cholangiocellular tumors as well as hepatic hemangiomas following subcutaneous injection, oral or skin administration. 2,2'-diamino-1,1'-dinaphthyl proved a potent carcinogenic agent; it is suggested that it might metabolize to such carcinogen as 2-naphthylamine.
Zabezhinskiĭ
M A
MA
N.N. Petrov Research Institute of Oncology, The Ministry of Health of the RF, St. Petersburg.
Pliss
G B
GB
D000818:Animals; D001650:Bile Duct Neoplasms / Q000139:chemically induced; D001943:Breast Neoplasms / Q000139:chemically induced; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009281:Naphthalenes / Q000633:toxicity*; D009369:Neoplasms / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced
D002273:Carcinogens; D009281:Naphthalenes; C122145:2,2'-diamino-1,1'-dinaphthyl