[Ednit influence on oxidation resistance of LDL lipoproteins in hypertensive subjects].
OBJECTIVE
Evaluation of resistance of low density lipoproteins (LDLP) of the serum to oxidation in patients with essential hypertension (EH) before and after course treatment with ednit.


METHODS
10 patients with mild or moderate EH aged 38-58 years were given ednit for 1 or 2 months. 10 healthy males aged 35-48 years served control.


RESULTS
EH patients had high baseline levels of lipid peroxidation products in LDLP, while antioxidant resistance of LDPL was diminished by 67% (p < 0.05) compared to controls. Ednit treatment for 1 and 2 months enhanced this resistance in mild and moderate EH (p < 0.05).


CONCLUSIONS
Ednit raises resistance of LDLP to oxidation and as ACE inhibitor lowers arterial pressure. Therefore it can be used in EH.
Ragino
Iu I
IuI
Latyntseva
L D
LD
Ivanova
M V
MV
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure; D004656:Enalapril / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D008077:Lipoproteins, LDL; D004656:Enalapril