Interleukin-6 receptor is highly expressed in the ganglionic eminence of the human fetal brain.
The expression of interleukin-6 receptor (IL-6R) has been investigated immunohistochemically in seven fetal brains with special reference to the ganglionic eminence (GE), a part of the telencephalic proliferative zone. Between the 22nd and 28th gestational week the GE stands out conspicuously due to its very high amount of intensely IL-6R-immunostained cells. Adjacent brain areas exhibit only very weak immunoreactivity. Between the 32nd and 36th week a moderate IL-6R immunolabelling is seen in the remnants of the GE. IL-6 may activate the immature IL-6R-positive cells to secrete a protease which is likely to be involved in GE involution and, perhaps, in the development of hemorrhage frequently occurring in the GE of premature infants.
Ulfig
N
N
Neuroembryonic Research Laboratory, Department of Anatomy, University of Rostock, Germany. norbert.ulfig@med.uni-rostock.de
Friese
K
K
D000911:Antibodies, Monoclonal; D001921:Brain / Q000196:embryology*; D005314:Embryonic and Fetal Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D020300:Intracranial Hemorrhages / Q000209:etiology; D019947:Receptors, Interleukin-6 / Q000235:genetics*
D000911:Antibodies, Monoclonal; D019947:Receptors, Interleukin-6