title: [A "typical" case of pulmonary embolism].
abstract: A 85-year-old woman was admitted to our hospital because of a presumtive diagnosis of pulmonary thromboembolism. The patient presented with a history of progressive dyspnoea and retrosternal pain. 3-4 weeks ago she had noticed a swollen left leg. On examination a 4/6-pansystolic murmur was found. An arterial blood gas analysis showed a reduced oxygen saturation. An electrocardiogram revealed deep S-waves in lead I and pathological Q-waves in lead III. The chest X-ray showed cardiomegaly, a pulmonary nodule and an ill-defined opacity inferioposteriorly. Ventilation-perfusion mismatch was demonstrated by lung ventilation-perfusion scanning. Transthoracic echocardiography showed pulmonary hypertension and tricuspid regurgitation. On the 20th hospital day the patient died from multi organ failure. Pulmonary thromboembolism secondary to deep venous thrombosis of the lower extremities was the most likely diagnosis. In view of the patients' history of night sweat, loss of appetite and weight loss a malignant process had to be taken into consideration. A tumor originating from the right ventricle, the right ventricular outflow tract or the pulmonary artery was compatible with the clinical picture of multiple pulmonary emboli. On autopsy a polymorph cellular sarcoma measuring 6 x 3 x 3 cm was found in the right ventricular outflow tract. Section of the lung revealed a single pulmonary metastasis and multiple thromboemboli of various age. Pulmonary artery sarcomas, as described in our case, are extremely rare. The prognosis is poor and often the diagnosis is only made on autopsy.
authors.affiliation: Medizinische Universitätsklinik A, Departement Innere Medizin, Kantonsspital Basel.
authors.forename: S
authors.initials: S
authors.lastname: Reichlin
authors.forename: H
authors.initials: H
authors.lastname: Saner
authors.forename: P
authors.initials: P
authors.lastname: Dalquen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D011651:Pulmonary Artery / Q000473:pathology; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D011660:Pulmonary Heart Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D011877:Radionuclide Imaging; D012509:Sarcoma / Q000473:pathology / Q000556:secondary; D013923:Thromboembolism / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D019043:Vascular Neoplasms / Q000473:pathology*