Rapidly growing primary gastric B-cell lymphoma after eradication of Helicobacter pylori.
Helicobacter pylori (H. pylori) infection plays a decisive role in primary gastric B-cell lymphoma especially of mucosa-associated lymphoid tissue (MALT)-type. We treated a 47-year-old male patient with primary gastric B-cell lymphoma associated with H. pylori infection. Although antibiotic therapy for eradication of H. pylori caused great improvement in the low-grade MALT lymphoma-like lesion, the small areas of high-grade lesion rapidly formed a new bulky mass in only 8 weeks. This suggests that eradication of H. pylori is not effective for high-grade lymphoma.
Furusyo
N
N
Department of General Medicine, Kyushu University Hospital, Fukuoka.
Kanamoto
K
K
Nakamura
S
S
Yao
T
T
Suekane
H
H
Yano
Y
Y
Ariyama
I
I
Hayashi
J
J
Kashiwagi
S
S
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000209:etiology* / Q000473:pathology; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D008795:Metronidazole; D017291:Clarithromycin; D009853:Omeprazole