[Diagnostic value of rosette-forming acetylcholine specific lymphocytes in the blood of myasthenia gravis patients].
In a blood of 37 patients with different forms of myasthenia (M) there was found an increase of a number of rosette-forming lymphocytes specific to acetylcholine in a specific rosette-forming reaction with acetylcholine erythrocytes' diagnostic kit. A value of this index correlated with a duration of the disease, with a degree of its generalization, with a degree of its severity and with the type of myasthenic process' course. Meanwhile, it wasn't depended on the age of the patients. In a blood of both healthy individuals and the patients with some other neurologic diseases a number of rosette-forming lymphocytes specific to acetylcholine was considerably lower. A number of the lymphocytes specific to acetylcholine was increased even in the debut of M and remained altered during all the period of the disease. That may serve as an additional diagnostic marker of M in any age, at different character and severity of the disease, in any phase of this pathology.
Shutov
A A
AA
Bykova
A A
AA
Ol'khovskaia
E F
EF
D000109:Acetylcholine / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000175:diagnosis*; D009388:Neostigmine; D012397:Rosette Formation; D012720:Severity of Illness Index
D015415:Biomarkers; D002800:Cholinesterase Inhibitors; D009388:Neostigmine; D000109:Acetylcholine