title: [A case of pyonephrosis caused by ureteral stones with elevated serum levels of CA19-9].
abstract: A case of pyonephrosis with high levels of serum CA19-9 antigen is reported. A 71-year-old woman was admitted with right flank pain. Computed tomography and ultrasonography showed severe hydronephrosis and hydroureter due to a right ureter stone. Laboratory data revealed a high level of serum CA19-9. However, no tumor was found in the pancreas, gallbladder, liver, gastrointenstinal tract or genitourinary tract. Drip infusion pyelography showed a non-functioning pattern of right kidney. Therefore, right nephroureterectomy was performed for right pyonephrosis. Histological examination revealed chronic inflammation. Malignant cells were not seen in the resected specimen. The serum CA19-9 levels before and after operation were 102.9 U/ml and 24 U/ml, respectively, being normal after the operation. Immunohistochemical examination revealed the presence of CA19-9 antigen in the urethelium, indicating its expression in the specimen. To our knowledge this might be the first case of pyonephrosis associated with high levels of serum CA19-9 antigen.
authors.affiliation: Department of Urology, Nagasaki University School of Medicine.
authors.forename: D
authors.initials: D
authors.lastname: Aoki
authors.forename: K
authors.initials: K
authors.lastname: Nomata
authors.forename: S
authors.initials: S
authors.lastname: Kanda
authors.forename: K
authors.initials: K
authors.lastname: Sawase
authors.forename: H
authors.initials: H
authors.lastname: Kanetake
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Tsuda
mesh_terms: D000368:Aged; D018395:CA-19-9 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D011704:Pyelonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014514:Ureteral Calculi / Q000150:complications*
chemical_list: D018395:CA-19-9 Antigen