Molecular mechanics aided design of antineoplastic agents from ruthenium coordinate complexes.
Through energy minimization using molecular mechanics force field four ruthenium cordinate complexes have been synthesized. Compound I to IV showed antineoplastic activity with varying degree on EAC bearing mice. Mode of action may be through inhibition of antioxidant property of tumor cell as evident from lipid peroxidase activity. Among the complexes Bis pyridine tetrachloro ruthenium exhibits highest order of activity with respect to increase mean survival time, inhibition of tumour volume, total blood count, hemoglobin and lipid peroxidase activity.
Mazumder
U K
UK
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Gupta
M
M
Mukherjee
A
A
Mukhopadhyay
D K
DK
Dey
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D017975:Ruthenium Compounds