title: Stability and compatibility of an aerosol mixture including N-acetylcysteine, netilmicin and betamethasone.
abstract: The physicochemical stability and the compatibility between N-acetylcysteine (1 g/5 ml), betamethasone (4 mg/1 ml) and netilmicin (100 mg/1 ml) were studied at room temperature (25+/-2 degrees C) over 1 h. During this study, drug concentrations were measured using three separate HPLC methods with UV detection at t=0, 5, 10, 20, 30, and 60 min. The pH of the mixture was determined. Degradation products of the drugs were assayed using HPLC. This study demonstrates the stability and compatibility of the mixture over 1 h at room temperature. The pinkish non-remnant coloration observed when pouring N-acetylcysteine into a recipient has no effect on the stability of the drug.
authors.affiliation: Service de Pharmacie et Laboratoire de Toxico-Pharmacologie, Hôpital Robert Debré, 48 Boulevard Sérurier, 75019, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Rieutord
authors.forename: P
authors.initials: P
authors.lastname: Arnaud
authors.forename: J F
authors.initials: JF
authors.lastname: Dauphin
authors.forename: F
authors.initials: F
authors.lastname: Brion
mesh_terms: D000111:Acetylcysteine / Q000032:analysis / Q000737:chemistry*; D000336:Aerosols / Q000032:analysis / Q000737:chemistry; D001623:Betamethasone / Q000032:analysis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D004344:Drug Incompatibility; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D009428:Netilmicin / Q000032:analysis / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000336:Aerosols; D009428:Netilmicin; D001623:Betamethasone; D000111:Acetylcysteine