title: A statistical method for correcting distortions of amplitude distribution histograms due to collisions of synaptic events.
abstract: The waveform of spontaneous synaptic potentials or currents comprising synaptic noise can be significantly distorted when these events are closely spaced due to a high frequency activity in the presynaptic inputs that generate them. It is essential to correct these alterations prior to measurements of overlapping miniature and/or postsynaptic potentials, in order to provide reliable information about their true amplitude distributions, and to avoid spurious peaks in the resulting histograms. In this paper we describe a statistical method for making these corrections, its range of application, and its theoretical background. Its use becomes necessary when the frequency of events is of the order of 8-50 Hz, depending upon their time to peak, which ranges from 6 to 1 ms in most synaptic potentials recorded in the central nervous system.
authors.affiliation: Laboratoire de Biologie Cellulaire et Moléculaire du Neurone, INSERM U261, Institut Pasteur, Paris, France. nankri@pasteur.fr
authors.forename: N
authors.initials: N
authors.lastname: Ankri
authors.forename: H
authors.initials: H
authors.lastname: Korn
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D000818:Animals; D004594:Electrophysiology; D006054:Goldfish; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D016008:Statistical Distributions; D013569:Synapses / Q000502:physiology*; D013997:Time Factors