Unique cytological features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics.
Chondroid lipoma is a rare, benign tumor that may mimic soft-tissue sarcoma clinically. Its histopathologic features may resemble hibernoma, myxoid liposarcoma, myxoid chondrosarcoma, and other lipomatous or chondroid neoplasms. In this study, a chondroid lipoma was analyzed by fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and metaphase fluorescence in situ hybridization. The results demonstrate that chondroid lipoma exhibits a characteristic pattern by fine-needle aspiration cytology, including a mixture of benign adipose tissue with lipoblastlike cells, and chondroblastlike cells with a fibrochondroid matrix. Cytogenetically, a three-way rearrangement between chromosomes 1, 2, and 5 was found, together with an 11;16 translocation with a breakpoint in 11q13, approximately 1 Mb proximal to the MEN1 region shown to be rearranged frequently in hibernoma. The presence of a karyotype of low complexity, but without any of the genetic aberrations characteristic for other types of soft-tissue tumors, indicate that chondroid lipoma develops along a unique pathogenetic pathway.
Gisselsson
D
D
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Domanski
H A
HA
Höglund
M
M
Carlén
B
B
Mertens
F
F
Willén
H
H
Mandahl
N
N
D000328:Adult; D001707:Biopsy, Needle; D002356:Cartilage / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D002871:Chromosome Banding; D020223:Chromosome Painting; D002877:Chromosomes, Human; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008854:Microscopy, Electron; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D014178:Translocation, Genetic
D004273:DNA, Neoplasm