title: Sequence analysis of SLA2 of the dimorphic yeasts Candida albicans and Yarrowia lipolytica.
abstract: We report the complete nucleotide sequence of SLA2 of the dimorphic yeasts Candida albicans and Yarrowia lipolytica. In Saccharomyces cerevisiae, SLA2 codes for an actin binding protein. The deduced amino acid (aa) sequences of C. albicans CaSla2p and Y. lipolytica YlSla2p consist of 1063 and 1054 aa, respectively. The alignment of the deduced proteins of Saccharomyces cerevisiae, Y. lipolytica and C. albicans shows regions of identity in the N-terminal part of the proteins, which are essential for growth at 37 degrees C, endocytosis and actin organization in S. cerevisiae. The Sla2p proteins have also several conserved regions in the C-terminal moiety, the I/LWEQ boxes, displaying homology to the talin protein of mouse, Dictyostelium discoideum, Caenorhabditis elegans and to human huntingtin interacting protein (Hip 1p). The sequence data of C. albicans SLA2 are registered in the EMBL database (AJ009556), and for the Y. lipolytica gene in GenBank (U65409).
authors.affiliation: Hans-Knöll-Institut für Naturstoff-Forschung e.V., Beutenbergstrasse 11, D-07745 Jena, Germany.
authors.forename: A S
authors.initials: AS
authors.lastname: Melms
authors.forename: U
authors.initials: U
authors.lastname: Gausmann
authors.forename: R K
authors.initials: RK
authors.lastname: Swoboda
authors.forename: A
authors.initials: A
authors.lastname: Dominguez
authors.forename: C
authors.initials: C
authors.lastname: Kurischko
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002176:Candida albicans / Q000235:genetics*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics*; D003598:Cytoskeletal Proteins; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics*; D005800:Genes, Fungal; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D005656:Fungal Proteins; C082266:SLA2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins