title: Prevalence of hypoxemia in 102 Japanese patients with alcoholic and nonalcoholic cirrhosis.
abstract: OBJECTIVE
  Liver cirrhosis is often accompanied by arterial hypoxemia in the absence of cardiopulmonary disease. The aim of this study was to investigate the relationship between various clinicopathological conditions and the hypoxemia seen in Japanese patients with liver cirrhosis.
  
  
  METHODS
  In 102 consecutive patients with alcoholic (N = 45) and nonalcoholic (N = 57) cirrhosis not associated with cardiopulmonary disease, we performed lung perfusion scintigraphy, contrast echocardiography, and arterial blood gas analysis and measured oxygen consumption.
  
  
  RESULTS
  No abnormality was seen in pulmonary blood flow in cirrhotic patients, but 38 (38%) of them had a decreased partial pressure of oxygen (PaO2). The hypoxemic patients did not show any pulmonary signs or symptoms. The hypoxemia was not associated with the Child-Pugh grade, and was observed in 32 (71%) of the 45 alcoholic patients but in only six (11%) of the 57 nonalcoholic patients (p < 0.001). Oxygen consumption was significantly higher in the alcoholic group than in the nonalcoholic group (p < 0.0001), and a high incidence of oxygen consumption was seen in all 45 (100%) of the alcoholic patients and in 34 (60%) of the nonalcoholic subjects, the difference being significant (p < 0.01). The relationship between oxygen consumption and PaO2 in the 102 cirrhotic patients showed an inverse correlation (r = -0.85, p < 0.0001). Among the alcoholic patients, the incidence of hypoxemia did not differ between the 33 smokers and the 12 nonsmokers. After 1 wk of abstinence from alcohol a significant increase (p < 0.0001) in the PaO2 was seen in 14 of 19 patients with alcoholic cirrhosis.
  
  
  CONCLUSIONS
  We conclude that the hypoxemia in Japanese patients with liver cirrhosis occurs mainly in drinking alcoholic patients, presumably due to an increased oxygen consumption by alcohol.
authors.affiliation: Department of Internal Medicine, Saiseikai Gotsu General Hospital, Gotsu-city, Shimane, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: C
authors.initials: C
authors.lastname: Hirayama
authors.forename: N
authors.initials: N
authors.lastname: Oyake
authors.forename: Y
authors.initials: Y
authors.lastname: Kadowaki
authors.forename: K
authors.initials: K
authors.lastname: Umeki
authors.forename: A
authors.initials: A
authors.lastname: Sagayama
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Kuzuo
authors.forename: Y
authors.initials: Y
authors.lastname: Ohuchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004452:Echocardiography; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D007564:Japan; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000503:physiopathology; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging
chemical_list: D010100:Oxygen