title: The synthesis of a new class of oxytocin antagonists.
abstract: The synthesis of a new class of oxytocin antagonists, with significantly modified C-terminal part, is described. The chemistry of the Mitsunobu reaction was applied to obtain the key derivatives. In spite of the extensive modifications of previously described compound F792, the peptides retain biological activity as oxytocin antagonists.
authors.affiliation: Ferring Research Institute, San Diego, CA 92121, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wiśniewski
authors.forename: J
authors.initials: J
authors.lastname: Trojnar
authors.forename: P
authors.initials: P
authors.lastname: Riviere
authors.forename: R
authors.initials: R
authors.lastname: Haigh
authors.forename: C
authors.initials: C
authors.lastname: Yea
authors.forename: D
authors.initials: D
authors.lastname: Ashworth
authors.forename: P
authors.initials: P
authors.lastname: Melin
authors.forename: A
authors.initials: A
authors.lastname: Nilsson
mesh_terms: D000818:Animals; D006801:Humans; D015394:Molecular Structure; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D018045:Receptors, Oxytocin / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D014668:Vasotocin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: C401405:F 792; D010456:Peptides, Cyclic; D018045:Receptors, Oxytocin; D011994:Recombinant Proteins; C047046:atosiban; D010121:Oxytocin; D014668:Vasotocin