[The antimutagenic activity of aspartame].
The method of chromosome aberration count in the bone marrow cells of C57B1/6 mice was used to study the influence of aspartame on the cytogenetic effects of dioxydin and cyclophosphan. Aspartame (0.4-40 mg/kg) was found to possess antimutagenic properties in relation to the listed mutagens. The discovered antimutagenic activity of aspartame was manifested more when it was injected for 5 days before the administration of a mutagen, whereas in joint administration of aspartame with the mutagens, the substitute for sugar did not change the clastogenic effect of dioxydin and cyclophosphan.
Kulakova
A V
AV
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Belogolovskaia
E G
EG
Oreshchenko
A V
AV
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001218:Aspartame / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D013997:Time Factors
D016587:Antimutagenic Agents; D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine; D003520:Cyclophosphamide; D001218:Aspartame