Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia.
B cell chronic lymphocytic leukaemia (CLL) shows evidence of familial aggregation, but the inherited basis is poorly understood. Mutations in the ATM gene have been demonstrated in CLL. This, coupled with a possibly increased risk of leukaemia in relatives of patients with Ataxia Telangiectasia, led us to question whether the ATM gene is involved in familial cases of CLL. To examine this proposition we typed five markers on chromosome 11q in 24 CLL families. No evidence for linkage between CLL and ATM in the 24 families studied and the best estimates of the proportion of sibling pairs that share no, one or both haplotypes at ATM were not different from their null expectations. This would imply that ATM is unlikely to make a significant contribution to the three-fold increase in risk of CLL seen in relatives of patients.
Bevan
S
S
Section of Cancer Genetics, Institute of Cancer Research, Sutton, UK.
Catovsky
D
D
Marossy
A
A
Matutes
E
E
Popat
S
S
Antonovic
P
P
Bell
A
A
Berrebi
A
A
Gaminara
E
E
Quabeck
K
K
Ribeiro
I
I
Mauro
F R
FR
Stark
P
P
Sykes
H
H
van Dongen
J
J
Wimperis
J
J
Wright
S
S
Yuille
M R
MR
Houlston
R S
RS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001260:Ataxia Telangiectasia / Q000235:genetics*; D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D002880:Chromosomes, Human, Pair 11; D004268:DNA-Binding Proteins; D005260:Female; D008040:Genetic Linkage; D018095:Germ-Line Mutation; D006579:Heterozygote; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017346:Protein Serine-Threonine Kinases; D011506:Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D011506:Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases