[2-year-old boy with recurrent mucocutaneous hemorrhage--Glanzmann thrombasthenia. Role of the fibrinogen receptor (glycoprotein IIb-IIIa) in thrombocyte function].
We report the clinical history of a patient suffering from a mucocutaneous bleeding diathesis since his birth. Discussing this case of Glanzmann's thrombasthenia we present essential aspects of clinical approach, diagnostic procedures and management of patients with platelet dysfunctions. Furthermore, we summarize the current understanding of platelet involvement in the haemostatic process and we discuss the role of the fibrinogen receptor glycoprotein IIb-IIIa.
Alberio
L
L
Hämatologisches Zentrallabor und Kinderklinik der Universität, Inselspital, Bern.
Hirt
A
A
D001780:Blood Coagulation Tests; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006474:Hemorrhagic Disorders / Q000097:blood / Q000209:etiology* / Q000235:genetics; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000235:genetics / Q000502:physiology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics / Q000502:physiology*; D013915:Thrombasthenia / Q000097:blood / Q000175:diagnosis* / Q000235:genetics
D019039:Platelet Glycoprotein GPIIb-IIIa Complex