title: A functional magnetic resonance imaging study of mental subtraction in human subjects.
abstract: The neuronal network involved in a precise type of calculation procedure, mental subtraction, was investigated by means of functional magnetic resonance imaging. Two tasks were used requiring covert production of numbers: (1) with calculation; (2) without calculation. During the first task, activation was observed in the left dorsolateral prefrontal and premotor cortices, in Broca's area and bilaterally in the inferior parietal cortex. During the second task, activation was mainly observed in Broca's area and to a less extent in the left prefrontal and premotor cortices. Statistical comparison of data in the two situations revealed that the procedure of mental subtraction is mediated by a distributed system which includes predominantly the left dorsolateral prefrontal cortex and the inferior parietal cortex bilaterally.
authors.affiliation: Laboratoire de Neurophysiologie CNRS UMR 5543, Université Victor Segalen Bordeaux 2, France. bdneuro@umr5543-bordeaux2.fr
authors.forename: P
authors.initials: P
authors.lastname: Burbaud
authors.forename: O
authors.initials: O
authors.lastname: Camus
authors.forename: D
authors.initials: D
authors.lastname: Guehl
authors.forename: B
authors.initials: B
authors.lastname: Bioulac
authors.forename: J M
authors.initials: JM
authors.lastname: Caillé
authors.forename: M
authors.initials: M
authors.lastname: Allard
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008433:Mathematics; D011340:Problem Solving / Q000502:physiology