[Roles of cytokines in wound healing processes].
In recent years, a number of studies have revealed the importance of cytokines and growth factors in the wound healing process. Cytokines, such as epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), transforming growth factor (TGF) alpha 1 and interleukin (IL)-6, have been shown to exhibit the particular ability to stimulate keratinocyte proliferation. In addition, bFGF and TGF beta 1 not only facilitate the migration of monocytes, neutrophils, macrophages, and fibroblasts, but also play a role in the generation of granulation tissue. Cytokine modulation of the repair process in both transitory and chronic wounds remains a very important subject for investigation. In this study, the clinical application of cytokines or cytokine-promoting drugs which were combined with or without collagen matrix is discussed as well as perspectives on wound care in the future.
Ono
I
I
Department of Dermatology, Fukushima Medical College, Japan.
D000818:Animals; D002056:Burns / Q000628:therapy; D002648:Child; D016207:Cytokines / Q000502:physiology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines