title: Vinylpyrrolidine-beta-cyclodextrin copolymer: a novel chiral selector for capillary electrophoresis.
abstract: The synthesis and characterization of a novel polymer consisting of an alkyl backbone and pendant beta-cyclodextrin units, obtained by radical copolymerization of vinylpyrrolidone and methacryloyl-beta-cyclodextrin (PVP-beta-CD), was reported. The ability of this copolymer to act as a capillary electrophoresis (CE) chiral selector was investigated in the separation of a mixture of basic drugs. The influence of polymeric cyclodextrin concentration, temperature, and pH on the separation of the test analytes was assessed and the advantage of using the polymeric selector over native beta-cyclodextrin was demonstrated.
authors.affiliation: Institute of Biocatalysis and Molecular Recognition, CNR, Milano, Italy. chiari@ico.mi.cnr.it
authors.forename: M
authors.initials: M
authors.lastname: Chiari
authors.forename: V
authors.initials: V
authors.lastname: Desperati
authors.forename: M
authors.initials: M
authors.lastname: Cretich
authors.forename: G
authors.initials: G
authors.lastname: Crini
authors.forename: L
authors.initials: L
authors.lastname: Janus
authors.forename: M
authors.initials: M
authors.lastname: Morcellet
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D003505:Cyclodextrins; D011759:Pyrrolidines; C400641:vinylpyrrolidine-beta-cyclodextrin copolymer