Occupational hazard evaluation of p-bromobenzyl bromide from tests for genotoxicity.
As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome aberration assay in Chinese hamster ovary cells. The compound produced equivocal results in the microbial mutagenicity assay but was negative in the alkaline elution assay for DNA strand breaks in rat hepatocytes. The compound produced weakly positive results in the in vitro chromosome aberration assay. There was substantial cytotoxicity in all three assays. It is concluded that p-BBB is weakly genotoxic.
Sargent
E V
EV
Toxicology and Environmental Health, Merck and Co., Inc., NJ 08889-0100, USA.
Sina
J F
JF
Barnum
J E
JE
Storer
R D
RD
Johnson
T E
TE
Galloway
S M
SM
Prato
M G
MG
Kirsten
N N
NN
Naumann
B D
BD
D000818:Animals; D001593:Benzyl Compounds / Q000633:toxicity*; D016466:CHO Cells / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004249:DNA Damage / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D016273:Occupational Exposure; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D001593:Benzyl Compounds; D009153:Mutagens; C401825:p-bromobenzyl bromide; D004247:DNA