[The effects of L-arginine in chronic pain syndromes].
The effect of L-arginine in long-term parenteral administration was studied on a model of neuropathic pain syndrome and adjuvant arthritis. L-arginine produced a preventive and therapeutic effect in the neuropathic pain syndrome. It weakened the development of adjuvant arthritis for the period of its administration. The factor underlying the effect of L-arginine is its double action as a precursor of nitrous oxide and kiotorphin, an endogenous antinociceptive dipeptide.
Danilova
E I
EI
Laboratory of Pain Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Grafova
V N
VN
Kukushkin
M L
ML
Zinkevich
V A
VA
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D001169:Arthritis, Experimental / Q000150:complications / Q000188:drug therapy / Q000517:prevention & control; D002908:Chronic Disease; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007279:Injections, Subcutaneous; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D051381:Rats; D013577:Syndrome; D013997:Time Factors
D000700:Analgesics; D001120:Arginine