Echinosulfonic acids A-C and echinosulfone A: novel bromoindole sulfonic acids and a sulfone from a southern australian marine sponge, echinodictyum
The crude EtOH extract of an Echinodictyum sp. collected during trawling operations in the Great Australian Bight, Australia, displayed antibacterial and antiparasitic properties. Bioassay-directed fractionation yielded three novel sulfonic acids, the echinosulfonic acids A to C (1-3), and a new sulfone, echinosulfone A (4). Structures were assigned to these compounds on the basis of detailed spectroscopic analysis. It was determined that echinosulfonic acids A-C (1-3) and echinosulfone A (4) contributed to the antibacterial but not antiparasitic activity of the crude extract.
Ovenden
SP
School of Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia.
Capon
RJ