Electrical remodeling in ischemia and infarction.
This is a review of the electrophysiologic changes occurring at different times following myocardial infarction, both in the infarcted region (substrate) and in areas remote from the infarct. Regulators of channel function which might contribute to re-modeling, including autocrine/paracrine factors involved in ion channel gene regulation, are discussed.
Pinto
J M
JM
Department of Pharmacology, Columbia College of Physicians and Surgeons, New York, NY 10032, USA.
Boyden
P A
PA
D000200:Action Potentials; D000818:Animals; D001693:Biological Transport, Active; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology; D004285:Dogs; D005786:Gene Expression Regulation; D006168:Guinea Pigs; D006801:Humans; D007473:Ion Channels / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D017136:Ion Transport; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012508:Sarcolemma / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D014158:Transcription, Genetic
D007473:Ion Channels