[Methods of autologous peripheral blood stem cell (PBSC) mobilization in oncological and hematological patients].
The potential of peripheral blood stem cell (PBSC) mobilization with granulocyte (G-CSF) and granulocyte-macrophage (GM-CSF) colony-stimulating factors of chemotherapy has been assessed in patients with tumor or hematological disease. The study was intended to aid PBSC transplantation. It was shown that G-CSF administration increased the number of leukocytes in leukemia patients dramatically while mononuclear cell and colony-forming unit levels in G-CSF-mobilised PBSC were significantly higher than those collected with GM-CSF or chemotherapy.
Fregatova
L M
LM
Acad. I.P. Pavlov State Medical University, St. Petersburg.
Shavva
S A
SA
Platonova
G G
GG
Golovacheva
A A
AA
Afanas'ev
B V
BV
D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006402:Hematologic Diseases / Q000097:blood* / Q000628:therapy; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D009369:Neoplasms / Q000097:blood* / Q000628:therapy; D016896:Treatment Outcome
D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor