title: Ciprofloxacin in treatment of nosocomial meningitis in neonates and in infants: report of 12 cases and review.
abstract: Twelve cases of neonatal and infant nosocomial meningitis treated with intravenous ciprofloxacin in doses of 10 to 60 mg/kg/day are described. Four neonates were 21 to 28 days old and eight infants were 2 to 6 months old. Six presented with Gram-negative meningitis: Escherichia coli (2), Salmonella enteritidis (1), Acinetobacter calcoaceticus (1), two with two organisms, and (H. influenzae plus Staphylococcus epidermidis, Acinetobacter spp. plus S. epidermidis), and six were attributable to Gram-positive cocci (four S. aureus and two Enterococcus faecalis). Ten cases were cured. In two cases, reversible hydrocephalus appeared that responded to intraventricular punctures. In seven children, no neurologic sequellae appeared after a 2- to 4-year follow-up. One neonate had relapse of meningitis 3 months later and was ultimately cured, but developed a sequellae of psychomotoric retardation. Follow-up varied from 27 months to 10 years. Current published case reports from Medline on quinolone use in meningitis in neonates and infants are reviewed.
authors.affiliation: Dept. of Paediatrics, University Hospital Kosice, Slovak Republic.
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
authors.forename: J
authors.initials: J
authors.lastname: Filka
authors.forename: J
authors.initials: J
authors.lastname: Uher
authors.forename: H
authors.initials: H
authors.lastname: Kurak
authors.forename: T
authors.initials: T
authors.lastname: Sagát
authors.forename: J
authors.initials: J
authors.lastname: Tuharský
authors.forename: I
authors.initials: I
authors.lastname: Novák
authors.forename: T
authors.initials: T
authors.lastname: Urbanová
authors.forename: K
authors.initials: K
authors.lastname: Kralinský
authors.forename: F
authors.initials: F
authors.lastname: Mateicka
authors.forename: T
authors.initials: T
authors.lastname: Krcméryová
authors.forename: L
authors.initials: L
authors.lastname: Jurga
authors.forename: M
authors.initials: M
authors.lastname: Sulcová
authors.forename: J
authors.initials: J
authors.lastname: Stencl
authors.forename: I
authors.initials: I
authors.lastname: Krúpová
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin