[A comparative study of the hemolytic activity of triterpene polyols of the dammarane series].
We studied membranotropic effect of dammarane-type triterpenes (isolated from birch leaves) with a variable side chain structure, as well as the number and configuration of OH groups as a function of temperature and pH. Polyols with an acyclic side chain and four OH groups proved to have a higher hemolytic activity as compared to polyols with three or five hydroxyl groups. The triterpenes, with tetrahydrofurane cycle as the side chain, exert a hemolytic effect at a more acidic pH (5.0) and higher temperature (45 degrees C), as compared to the polyols with acyclic side chain. Irrespective of the side chain structure, the compounds with a 24(S) configuration lysed the erythrocytes at lower rate, as compared to the compounds with a 24(R) configuration.
Prokof'eva
N G
NG
Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, Vladivostok, Russia.
Shentsova
E B
EB
Stekhova
S I
SI
Anisimov
M M
MM
Pokhilo
N D
ND
Uvarova
N I
NI
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D013256:Steroids / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013696:Temperature; D014197:Trees; D014315:Triterpenes / Q000494:pharmacology*; D000097669:Dammaranes
D010936:Plant Extracts; D013256:Steroids; D014315:Triterpenes; D000097669:Dammaranes