title: Effects of physical therapy on cytokines and two color analysis-lymphocyte subsets in patients with cerebrovascular diseases.
abstract: The effects of physical therapy on immunological parameters were evaluated in 12 patients (8 males and 4 females, 69.2 +/- 9.0 years) with cerebrovascular diseases in a stable situation two to three months after the onset of stroke who entered in our hospital between 1994 and 1997. After a two-month physical therapy program, the proportions of helper-inducer T (Thi) cells and suppressor-inducer T (Tsi) cells were increased significantly and that of cytotoxic T (Tc) cells was decreased, although those of HLA-DR+, suppressor T (Ts) and activated T (Tac) cells were not changed. The antibody dependent cellular cytotoxicity (ADCC) was significantly increased, although natural killer (NK) cell activity was not changed. The serum levels of interleukin-2 receptor was significantly increased but those of interleukin-2, interleukin-6 and interleukin-12 were not changed. The serum levels of interleukin-10, interleukin-12 and tumor necrosis factor-alpha were not detectable, while interleukin-1beta was decreased in 2 patients and interleukin-10 was increased in 2 patients. These findings suggest that daily physical exercise may activate the immune system possibly through the cytokine network in patients with cerebrovascular diseases (CVD).
authors.affiliation: Division of Rehabilitation, Kusatsu Branch Hospital, Gunma University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurabayashi
authors.forename: I
authors.initials: I
authors.lastname: Machida
authors.forename: H
authors.initials: H
authors.lastname: Handa
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Akiba
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: J
authors.initials: J
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000368:Aged; D000072038:Cardiac Rehabilitation; D002318:Cardiovascular Diseases / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D020521:Stroke / Q000276:immunology; D000071939:Stroke Rehabilitation
chemical_list: D016207:Cytokines