The role of the parathyroid glands in adrenocorticotrophin-induced hypertension in the rat.
The aim of this study was to determine whether parathyroidectomy (PTx) would modify hypertension secondary to adrenocorticotrophin (ACTH) administration. Male Sprague Dawley (SD) rats were randomly assigned to one of five groups; (i) sham (saline) treatment (NaCl 0.9% s/c 0.5 ml/kg/day), (ii) ACTH treatment (Synacthen Depot 0.5 mg/kg/day), (iii) saline/PTx/1% CaCl2 in water, (iv) ACTH/PTx/1% CaCl2 in water and (v) ACTH/1% CaCl2 in water. Tail cuff systolic blood pressure (SBP) and metabolic parameters were measured on alternate days for 4 control (C) and 11 treatment days (T0-T10). There was no change in SBP in the sham and saline/PTx/CaCl2 groups over T0-10. SBP increased in the ACTH treated groups. PTx did not modify ACTH-induced increases in SBP or metabolic effects. These results do not support a role for the parathyroids in the genesis of ACTH-induced hypertension in the rat.
Mangos
G J
GJ
Department of Medicine, St George Hospital, University of New South Wales, Kogarah, Australia.
Fraser
T B
TB
Turner
S W
SW
Whitworth
J A
JA
D000324:Adrenocorticotropic Hormone / Q000633:toxicity*; D000818:Animals; D001685:Biological Factors / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D011188:Potassium / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000097:blood
D001685:Biological Factors; D010281:Parathyroid Hormone; C064505:parathyroid hypertensive factor; D000324:Adrenocorticotropic Hormone; D012964:Sodium; D011188:Potassium; D002118:Calcium