[The dynamics of the chronotropic effect of a single vagal stimulus in cats under the action of met-enkephalin and neurotensin].
Following a burst of pulses applied to the vagus nerve with progressively incremental delay after the P wave of the ECG, the narrow zone of the cardiac cycle was identified where even a small shift of the vagal burst position evoked an abrupt alteration of the chronotropic effect magnitude. Met-enkephalin potentiated the phase-dependent vagal chronotropic effect, whereas neurotensin moved its limits toward the initial part of the P-P interval.
Osadchiĭ
O E
OE
Kuban Medical Academy, Krasnodar, Russia.
Pokrovskiĭ
V M
VM
D000818:Animals; D002415:Cats; D004558:Electric Stimulation / Q000379:methods; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D009496:Neurotensin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014630:Vagus Nerve / Q000502:physiology*
D009496:Neurotensin; D004744:Enkephalin, Methionine