title: Expression of lectin binding in oral submucous fibrosis.
abstract: Lectins are a group of specific glycoproteins present in cells, particularly cell membrane. Recently, lectin binding studies have been used as a diagnostic as well as prognostic indicator of neoplasm's. Oral submucous fibrosis (OSMF) is a potential premalignant condition predominantly seen in Indian subcontinent. A comparison of expression of lectin binding was studied in normal tissue, OSMF cases and oral squamous cell carcinoma. The OSMF cases were grouped into early and advanced conditions as per the histopathologic criteria. Patterns of lectin binding observed with advanced OSMF cases were comparable with that of Oral squamous cell carcinoma. The role of lectin binding studies in assessing the malignant potential of a pre-malignant condition is discussed.
authors.affiliation: Department of Oral Pathology & Microbiology, Dental College, Calicut, India. afotrv@md2.vsnl.net.in
authors.forename: V T
authors.initials: VT
authors.lastname: Beena
authors.forename: S
authors.initials: S
authors.lastname: Anil
authors.forename: P
authors.initials: P
authors.lastname: Remani
authors.forename: T
authors.initials: T
authors.lastname: Vijayakumar
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000378:metabolism*; D009914:Oral Submucous Fibrosis / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D037102:Lectins