A comparison of the renal handling of 99Tcm-DTPA and 99Tcm-MAG3 in hypertensive patients using an uptake technique.
The renal uptake and outflow of 99Tcm-DTPA and 99Tcm-MAG3 were compared by analysing renal studies performed in two different departments, but with analysis techniques and computer programs using algorithms that were almost identical. Comparison was performed by a retrospective review of results from patients who were referred for renal investigations because of hypertension but who had apparently normal kidneys. The analysis of tracer outflow rates in the form of whole-kidney transit times and renal cortical transit times showed no significant difference between the two tracers. The fractional uptake rate of tracer for each patient (both kidneys) indicated that MAG3 was extracted from the blood 3.3 times faster than DTPA in patients aged 20-69 years, with a lower ratio above the age of 70. When used to measure relative renal function, there was no overall difference between the two tracers. The fractional uptake rates were also converted to flow rates, producing values of 95.8 +/- 28.0 ml.min(-1).1.73 m-2 for DTPA and 320 +/- 75 ml.min(-1).1.73 m-2 for MAG3, in hypertensive patients aged 20-40 years. These values showed a good correlation with other published GFR and MAG3 clearance rates (obtained using blood sampling methods) in normal patients of similar ages.
Rutland
M D
MD
Auckland Hospital, New Zealand. mrutland@ahsl.com.nz
Que
L
L
D000328:Adult; D000368:Aged; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000652:urine*; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007672:Kidney Cortex / Q000000981:diagnostic imaging / Q000378:metabolism; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals / Q000652:urine*; D017263:Technetium Tc 99m Mertiatide / Q000652:urine*; D016284:Technetium Tc 99m Pentetate / Q000652:urine*
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide; D016284:Technetium Tc 99m Pentetate