title: Malignant paraganglioma of frontoethmoidal region.
abstract: Nonchromaffin paragangliomas are unusual tumours arising from widely distributed paraganglionic tissues probably of neural crest origin. In the head and neck region they are usually seen as carotid body or jugulotympanic tumours. Other rarely reported sites in the head and neck region are the orbit, nose and larynx. This report deals with a case of sinonasal paraganglioma which was initially treated with surgery and radiotherapy. Twenty two years later the tumour recurred and showed a rapid growth due to malignant transformation which we believe is late effect of radiotherapy. The clinical features, histopathology and role of radiotherapy in sinonasal paragangliomas together with a review of the medical literature have been discussed.
authors.affiliation: Department of Otorhinolaryngology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan. sharma@kb.usm.my
authors.forename: H S
authors.initials: HS
authors.lastname: Sharma
authors.forename: M
authors.initials: M
authors.lastname: Madhavan
authors.forename: N H
authors.initials: NH
authors.lastname: Othman
authors.forename: M
authors.initials: M
authors.lastname: Muhamad
authors.forename: J M
authors.initials: JM
authors.lastname: Abdullah
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005005:Ethmoid Sinus / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005626:Frontal Sinus / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed