Preeclampsia and genetic risk factors for thrombosis: a case-control study.
OBJECTIVE
Recently, it has been proposed that hereditary coagulation abnormalities leading to an increased venous thrombosis risk may play a role in the development of preeclampsia. We tested this hypothesis in women who have had preeclampsia compared with matched control subjects.


METHODS
We conducted a case-control study of 163 women with preeclampsia during 1991-1996. Control subjects were matched for age and delivery date. Patients and control subjects were tested for the presence of factor V Leiden, prothrombin 20210A allele, protein C, protein S, and antithrombin deficiency. Logistic regression methods were used for data analysis.


RESULTS
The prevalence of these genetic risk factors was similar in the patient group (12.9%) and the control group (12.9%; odds ratio, 1.0; 95% confidence interval, 0.5-3.9). Unexpectedly, we found a high prevalence of factor V Leiden in the control group (9.2%).


CONCLUSIONS
We found no differences in the prevalence of genetic risk factors of thrombosis in women with preeclampsia compared with control subjects.
De Groot
C J
CJ
Department of Obstetrics, Leiden University Medical Center, The Netherlands.
Bloemenkamp
K W
KW
Duvekot
E J
EJ
Helmerhorst
F M
FM
Bertina
R M
RM
Van Der Meer
F
F
De Ronde
H
H
Oei
S G
SG
Kanhai
H H
HH
Rosendaal
F R
FR
D000991:Antithrombins / Q000172:deficiency; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics; D005260:Female; D005313:Fetal Death / Q000235:genetics; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011486:Protein C / Q000235:genetics; D017293:Protein S / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
D000991:Antithrombins; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin