title: Effects of smoking on local delivery of controlled-release doxycycline as compared to scaling and root planing.
abstract: This paper examines the effects of smoking on the treatment outcomes of two nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-release of subgingivally delivered doxycycline hyclate in a polylactic acid based polymer gel. Subjects from 2 9-month multicenter studies were classified as nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed for treated sites with baseline probing depths > or = 5 mm and for a subset of treated sites with baseline probing depths of > or = 7 mm. Clinical parameters (plaque levels, clinical attachment levels, pocket depths, and bleeding on probing) were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in general, there were neither marked significant differences in clinical attachment gain nor differences in probing depth reduction among the 3 smoking groups. On the other hand, in the scaling and root planing treated group in general, there were significant differences in clinical attachment gain and pocket depth reduction, with non-smokers responding better than former smokers and current smokers at 6 and 9 months. These differences in clinical response between scaling and root planing alone versus controlled-release of locally-delivered doxycycline hyclate among these 3 smoking groups are discussed in relation to treatment implications for smokers.
authors.affiliation: University of California San Francisco/School of Dentistry, USA. mirper@itsa.ucsf.edu
authors.forename: M I
authors.initials: MI
authors.lastname: Ryder
authors.forename: B
authors.initials: B
authors.lastname: Pons
authors.forename: D
authors.initials: D
authors.lastname: Adams
authors.forename: B
authors.initials: B
authors.lastname: Beiswanger
authors.forename: V
authors.initials: V
authors.lastname: Blanco
authors.forename: G
authors.initials: G
authors.lastname: Bogle
authors.forename: K
authors.initials: K
authors.lastname: Donly
authors.forename: W
authors.initials: W
authors.lastname: Hallmon
authors.forename: E B
authors.initials: EB
authors.lastname: Hancock
authors.forename: P
authors.initials: P
authors.lastname: Hanes
authors.forename: C
authors.initials: C
authors.lastname: Hawley
authors.forename: L
authors.initials: L
authors.lastname: Johnson
authors.forename: H L
authors.initials: HL
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Wolinsky
authors.forename: R
authors.initials: R
authors.lastname: Yukna
authors.forename: A
authors.initials: A
authors.lastname: Polson
authors.forename: G
authors.initials: G
authors.lastname: Carron
authors.forename: S
authors.initials: S
authors.lastname: Garrett
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003774:Dental Plaque Index; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D019344:Lactic Acid; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010510:Periodontal Diseases / Q000188:drug therapy / Q000628:therapy*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D011091:Polyesters; D011108:Polymers; D016745:Root Planing; D016037:Single-Blind Method; D012907:Smoking / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D004318:Doxycycline