Low serum C3, leukopenia, and thrombocytopenia: unusual features of henoch-schonlein purpura.
Henoch-Schonlein purpura (HSP) affects predominantly the skin, joints, gastrointestinal tract and kidney. Although the pathogenesis is probably of immune origin and complement activation is thought to play a role, laboratory findings including the serum level of the complement components are usually normal. We present a patient with a severe form of HSP nephritis who had unusual laboratory findings of a low level of C3, mild leukopenia and thrombocytopenia. These findings may further support the importance of complement activation in the pathogenesis of HSP.
Krause
I
I
Nephrology Clinic and Dialysis Unit, Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel-Aviv University, Petah-Tiqva, Israel. ikrause@post.tau.ac.il
Garty
B Z
BZ
Davidovits
M
M
Cleper
R
R
Tamary
H
H
Rosenmann
E
E
Eisenstein
B
B
D001707:Biopsy, Needle; D002648:Child; D015932:Complement C3c / Q000032:analysis*; D018450:Disease Progression; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000175:diagnosis*; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D006435:Renal Dialysis; D013921:Thrombocytopenia / Q000209:etiology*
D015932:Complement C3c