title: Putative skin-protective formulations in preventing and/or inhibiting experimentally-produced irritant and allergic contact dermatitis.
abstract: The effectiveness of skin protective formulations was evaluated in a previously-described in vivo human model. All formulations failed to inhibit ammonium hydroxide and urea irritation. Only paraffin wax in cetyl alcohol statistically (p<0.01) reduced Rhus allergic contact dermatitis. 3 commercial formulations markedly (p<0.001) suppressed sodium lauryl sulfate irritation. Paraffin wax in cetyl alcohol was quantitatively the most effective formulation. These results suggest that some formulations may provide protective effects against certain, but not all, irritants or allergens.
authors.affiliation: Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.
authors.forename: H
authors.initials: H
authors.lastname: Zhai
authors.forename: P
authors.initials: P
authors.lastname: Willard
authors.forename: H I
authors.initials: HI
authors.lastname: Maibach
mesh_terms: D000328:Adult; D064753:Ammonium Hydroxide; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000517:prevention & control*; D017453:Dermatitis, Irritant / Q000209:etiology / Q000517:prevention & control*; D011040:Dermatitis, Toxicodendron / Q000209:etiology / Q000517:prevention & control; D005233:Fatty Alcohols / Q000494:pharmacology; D006801:Humans; D006878:Hydroxides / Q000009:adverse effects; D007509:Irritants / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010232:Paraffin / Q000494:pharmacology; D010328:Patch Tests; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D010947:Plants, Toxic; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D012251:Toxicodendron / Q000009:adverse effects
chemical_list: D005233:Fatty Alcohols; D006878:Hydroxides; D007509:Irritants; D010592:Pharmaceutic Aids; D012967:Sodium Dodecyl Sulfate; D064753:Ammonium Hydroxide; D010232:Paraffin; C005031:cetyl alcohol