[Nicotinamide in combined treatment of chronic pancreatitis].
OBJECTIVE
To evaluate effects of nicotinamide on insulin secretion in glucose tolerance test and on blood clotting in patients with chronic pancreatitis (CP).


METHODS
30 patients with CP of alcoholic etiology received combined treatment with enzyme medicines. In addition, some of them were administered nicotinamide as 2.5% solution for 2 weeks (1 ml twice a day). Before the treatment and during its course, measurements were made of fasting and post glucose test values of insulin secretion and thromboelastogram.


RESULTS
Both basal and stimulated insulin secretion in CP patients was low compared to control subjects. Nicotinamide significantly increased basal secretion of insulin and insignificantly aroused its glucose-stimulated secretion. Nicotinamide promoted reduction of hypercoagulation and time to remission.


CONCLUSIONS
Nicotinamide administration is thought valid for correction of endocrine pancreatic function and hemocoagulation in patients with alcoholic CP.
Loginov
A S
AS
Matiushin
B N
BN
Astaf'eva
O V
OV
Nilova
T V
TV
Vinokurova
L V
LV
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D004359:Drug Therapy, Combination; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D019512:Pancreatitis, Alcoholic / Q000097:blood / Q000188:drug therapy*; D011863:Radioimmunoassay; D012074:Remission Induction; D013916:Thrombelastography; D016896:Treatment Outcome
D001786:Blood Glucose; D005765:Gastrointestinal Agents; D007328:Insulin; D009536:Niacinamide