title: Terminal differentiation and left-handed Z-DNA: a review.
abstract: Nucleic acids control the expression of genes, and different conformations of DNA structure may regulate cell death. Left-handed Z-DNA, which is speculated to function as a transcriptional enhancer, may be directly influenced by the destructive effects of terminal differentiation. The nicking-denaturation of double-stranded Z-DNA could possibly initiate and enhance terminal differentiation within specific tissues.
authors.affiliation: Department of Pathology and Laboratory Medicine, Rm #C508c, University of Medicine and Dentistry of New Jersey-Medical School, 185 S. Orange Avenue, Newark, NJ 07103, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Gagna
authors.forename: H r
authors.initials: Hr
authors.lastname: Kuo
authors.forename: W C
authors.initials: WC
authors.lastname: Lambert
mesh_terms: D000818:Animals; D016923:Cell Death; D002454:Cell Differentiation; D004247:DNA; D005786:Gene Expression Regulation; D006801:Humans; D009691:Nucleic Acid Denaturation
chemical_list: D004247:DNA