Survival and prognostic factors in patients with resected epidermoid oesophageal carcinoma.
To determine long-term survival of patients with thoracic oesophageal tumor who underwent resection, and to identify possible associated prognostic factors, 58 patients underwent oesophagectomy alone (group A) and 16 combined with neo-adjuvant chemoradiotherapy (group B). Univariate and multivariate analysis of prognostic factors were performed for age, depth of oesophageal wall tumour penetration, node involvement, type of resection, TNM stage and degree of tumour differentiation. Long-term survival rates at 1-5 years were 81% versus 89%; 56% versus 67%; 30% versus 67%; 12% versus 44%; and 0% versus 33% for group A and B, respectively (P = 0.0543, NS). Univariate analysis revealed only depth of invasion (P = 0.0076) and TNM stage (P = 0.0452) as isolated prognostic factors for long-term survival and multivariate analysis did not demonstrate any independent factor. Despite the small number of cases, neoadjuvant chemoradiotherapy seems to improve prognosis as well as to allow resection in a greater number of cases due to tumor downstaging.
Rosa
A R
AR
Department of Surgery, School of Medicine, Federal University of Rio Grande do Sul, Brazil. andrerpr@opensite.com.br
Gurski
R R
RR
Schirmer
C C
CC
Brentano
L
L
Kruel
C D
CD
D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D016629:Esophagectomy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate