title: Novel Catalytic Hydrogenolysis of Trimethylsilyl Enol Ethers by the Use of an Acidic Ruthenium Dihydrogen Complex.
abstract: The heterolytic cleavage of H(2) is the key to the novel catalytic hydrogenolysis of trimethylsilyl enol ethers catalyzed by [RuCl(eta(2)-H(2))(dppe)(2)]OTf (dppe = 1,2-bis(diphenylphosphanyl)ethane, OTf = trifluoromethanesulfonate), which results in the formation of a ketone and Me(3)SiH (see scheme). In addition, the stoichiometric, ruthenium-assisted protonation of a prochiral lithium enolate with H(2) gave a chiral ketone with high enantioselectivity (up to 75 % ee).
authors.affiliation: Department of Chemistry and Biotechnology Graduate School of Engineering, The University of Tokyo, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8656 (Japan).
authors.initials: Y
authors.lastname: Nishibayashi
authors.initials: I
authors.lastname: Takei
authors.initials: M
authors.lastname: Hidai