Adrenoleukodystrophy associated with vitiligo and ulcerative colitis.
Adrenoleukodystrophy (ALD) is an X-linked inherited disorder of lipid metabolism usually presenting in childhood or early adolescence. It is a progressive disease with symptoms of adrenal insufficiency and central nervous system demyelination. The pathology results from the accumulation of very long-chain fatty acids and an inflammatory reaction in the brain white matter. We report a case of ALD associated with adrenal insufficiency and two autoimmune diseases: vitiligo and ulcerative colitis.
Sawaya
R A
RA
Department of Internal Medicine, American University Medical Center, Beirut, Lebanon. rasawaya@cyberia,net.lb
Mourad
F H
FH
Najjar
S
S
Mikati
M
M
Raymond
G V
GV
D000224:Addison Disease / Q000150:complications*; D000311:Adrenal Glands / Q000378:metabolism; D000326:Adrenoleukodystrophy / Q000150:complications* / Q000378:metabolism; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications; D003093:Colitis, Ulcerative / Q000150:complications* / Q000276:immunology; D017809:Fatal Outcome; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008297:Male; D014820:Vitiligo / Q000150:complications* / Q000276:immunology
D005227:Fatty Acids