title: Determinants of disease outcome following Helicobacter pylori infection in children.
abstract: Helicobacter pylori infection is primarily acquired during childhood, causes chronic, active gastritis and peptic ulcer disease, and is associated with the development of gastric malignancies. However, only a small number of infected individuals ever develop the more severe sequelae of peptic ulcer disease and gastric cancers. Therefore, the identification of bacterial and host factors that play a role in determining the outcomes and pathophysiology of infection is a major focus of current research. Recent advances in the understanding of disease pathogenesis are critically considered, with particular reference to the pediatric population.
authors.affiliation: Division of Gastroenterology/Nutrition, Research Institute, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: N L
authors.initials: NL
authors.lastname: Jones
authors.forename: A S
authors.initials: AS
authors.lastname: Day
authors.forename: P M
authors.initials: PM
authors.lastname: Sherman
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002648:Child; D005753:Gastric Mucosa / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D016481:Helicobacter Infections / Q000150:complications / Q000503:physiopathology; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D008679:Metaplasia / Q000382:microbiology; D010437:Peptic Ulcer / Q000382:microbiology; D013274:Stomach Neoplasms / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori