A collagen network formation effector from leaves of Premna subscandens.
As a part of the search for biologically active plant products, M cells, which form a collagen fiber network in vitro after a prolonged culture period, were used. The n-BuOH-soluble fraction of a methanol extract of leaves of Premna subscandens exhibited promotion of collagen network formation by M cells. Extensive isolation work guided by a bioassay afforded a phenylethanoid, acteoside, as an active compound.
Sudo
H
H
Institute of Pharmaceutical Sciences, Hiroshima University Faculty of Medicine, Japan.
Kijima
K
K
Otsuka
H
H
Ide
T
T
Hirata
E
E
Takeda
Y
Y
Isaji
M
M
Kurashina
Y
Y
D002460:Cell Line; D003094:Collagen / Q000378:metabolism*; D004396:Coloring Agents; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013268:Stimulation, Chemical
D004396:Coloring Agents; D010936:Plant Extracts; D003094:Collagen