Expression of the highly conserved RNA binding protein KOC in embryogenesis.
The human KOC gene which is highly expressed in cancer shows typical structural features of an RNA binding protein. We analyzed the temporal and spatial expression pattern of KOC in mouse embryos at different gestational ages. The expression of KOC seems to be ubiquitous at early stages. During advanced gestation highest KOC expression occurs in the gut, pancreas, kidney, and in the developing brain. The expression pattern of KOC was compared to its Xenopus homologue Vg1-RBP during frog development. Similar expression was found in these organs suggesting an important functional role of the homologous proteins in embryonic development.
Mueller-Pillasch
F
F
Department of Internal Medicine I, University of Ulm, Germany. frederike.mueller-pillasch@medizin.uni-ulm.de
Pohl
B
B
Wilda
M
M
Lacher
U
U
Beil
M
M
Wallrapp
C
C
Hameister
H
H
Knöchel
W
W
Adler
G
G
Gress
T M
TM
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D017124:Conserved Sequence; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D009363:Neoplasm Proteins; D010179:Pancreas / Q000196:embryology / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D016212:Transforming Growth Factor beta; D014981:Xenopus / Q000196:embryology / Q000235:genetics; D029867:Xenopus Proteins
C513103:GDF1 protein, Xenopus; D006023:Glycoproteins; C498780:IGF2BP3 protein, human; C498777:Igf2bp3 protein, mouse; D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins