The synthesis of a new class of oxytocin antagonists.
The synthesis of a new class of oxytocin antagonists, with significantly modified C-terminal part, is described. The chemistry of the Mitsunobu reaction was applied to obtain the key derivatives. In spite of the extensive modifications of previously described compound F792, the peptides retain biological activity as oxytocin antagonists.
Wiśniewski
K
K
Ferring Research Institute, San Diego, CA 92121, USA.
Trojnar
J
J
Riviere
P
P
Haigh
R
R
Yea
C
C
Ashworth
D
D
Melin
P
P
Nilsson
A
A
D000818:Animals; D006801:Humans; D015394:Molecular Structure; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D018045:Receptors, Oxytocin / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism; D014668:Vasotocin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
C401405:F 792; D010456:Peptides, Cyclic; D018045:Receptors, Oxytocin; D011994:Recombinant Proteins; C047046:atosiban; D010121:Oxytocin; D014668:Vasotocin