title: Minimal incidence of serum antibodies reactive with intact primary isolate virions in human immunodeficiency virus type 1-infected individuals.
abstract: Immunoglobulin G reactive with primary isolate virions was detected in 36% of serum samples from individuals infected with human immunodeficiency virus type 1. Of these individuals, serum samples from only 7% captured significant quantities of virus. Virion-specific antibody correlated with CD4 counts and, of more significance, primary isolate neutralization. Further dissection of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA. lcavacin@caregroup.harvard.edu
authors.forename: L A
authors.initials: LA
authors.lastname: Cavacini
authors.forename: J E
authors.initials: JE
authors.lastname: Peterson
authors.forename: E
authors.initials: E
authors.lastname: Nappi
authors.forename: M
authors.initials: M
authors.lastname: Duval
authors.forename: R
authors.initials: R
authors.lastname: Goldstein
authors.forename: K
authors.initials: K
authors.lastname: Mayer
authors.forename: M R
authors.initials: MR
authors.lastname: Posner
mesh_terms: D018791:CD4 Lymphocyte Count; D015483:HIV Antibodies / Q000097:blood* / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D014771:Virion / Q000276:immunology
chemical_list: D015483:HIV Antibodies; D007074:Immunoglobulin G