title: Low environmental selenium availability as an additional determinant for goiter in East Java, Indonesia?
abstract: Iodine deficiency, which is most visibly indicated by goiter, is highly prevalent in Indonesia. Since 1994, Indonesia has a decree that all salt used for human, livestock, and industry must be iodized. However, despite the increased distribution of iodized salt, pockets with significantly higher prevalence of goiter still remain. This situation may be consequence of selenium (Se) deficiency. This study aimed to assess the Se level in the environment of goiter prevalent areas. Five hundred eleven school children participated in this study. Goiter was measured using both ultrasound and palpation. Ninety-nine eggs were collected from free-living chicken in 11 villages, and the Se contents of egg yolk and egg white were determined by neutron activation analysis. In the villages studied, Se concentration in egg yolk ranged from 0.15 to 1.52 microg/g and in egg white from 0.18 to 2.97 microg/g. The prevalence of goiter measured by palpation ranged from 18.4% to 70% and by ultrasound from 0% to 100%. Because of the inconsistency of goiter rate measured by palpation and ultrasonography, the question remains whether low availability of Se in the environment might be an additional contributing factor for goiter.
authors.affiliation: SEAMEO-TROPMED, Jakarta, Indonesia.
authors.forename: J
authors.initials: J
authors.lastname: Untoro
authors.forename: M
authors.initials: M
authors.lastname: Ruz
authors.forename: R
authors.initials: R
authors.lastname: Gross
mesh_terms: D002648:Child; D003430:Cross-Sectional Studies; D004530:Egg Yolk / Q000737:chemistry*; D004784:Environmental Monitoring / Q000379:methods / Q000706:statistics & numerical data*; D062665:Epidemiological Monitoring; D005260:Female; D006042:Goiter / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000378:metabolism*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D012643:Selenium / Q000032:analysis*; D014463:Ultrasonography
chemical_list: D012643:Selenium