title: Reduction in blood glucose values following indomethacin therapy for patent ductus arteriosus.
abstract: OBJECTIVE
  To evaluate the effects of indomethacin on blood glucose values in premature infants with patent ductus arteriosus (PDA).
  
  
  METHODS
  Twenty-five very low birthweight infants with PDA were given 0.2 mg/kg, i.v., indomethacin for up to three doses. We examined the relationship between blood glucose values and glucose infusion rate before and after indomethacin therapy.
  
  
  RESULTS
  There was a significant reduction in blood glucose values between 12 and 96 h following i.v. indomethacin therapy. Eleven of 25 infants (44%) had blood glucose values below 40 mg/dL between 12 and 60 h (mean 32.7 h) after the initial dose. Although the glucose infusion rate during the first 12 h was constant (3.56 +/- 0.98 mg/kg per min), the blood glucose values decreased from 96 +/- 32 mg/dL at the starting point to 75 +/- 29 mg/dL at 12 h (P < 0.05). The maximum blood glucose reduction was 51.6 +/- 34.7 mg/dL and the maximum blood glucose reduction rate was 50.4 +/- 20.2%.
  
  
  CONCLUSIONS
  The results suggest that blood glucose values should be measured at least every 6 h for 72 h until they stabilize in order to prevent unexpected hypoglycemia.
authors.affiliation: Division of Neonatology, Saitama Children's Medical Center, Japan. hosonos@rb3.so-net.ne.jp
authors.forename: S
authors.initials: S
authors.lastname: Hosono
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Kimoto
authors.forename: R
authors.initials: R
authors.lastname: Nagoshi
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Nozawa
mesh_terms: D002317:Cardiovascular Agents / Q000009:adverse effects*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D008297:Male; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D002317:Cardiovascular Agents; D007213:Indomethacin