Adult-onset angiofibroma and multiple endocrine neoplasia type I.
Multiple endocrine neoplasia type 1 (MEN 1) predisposes affected persons to neoplasms of the parathyroid glands, the endocrine pancreas, the anterior pituitary, and the duodenum. We report the first case of adult-onset multiple angiofibromas of the central face associated with MEN 1. Seven siblings also developed adult-onset angiofibromas, none with evidence of tuberous sclerosis. Basic fibroblast growth factor (BFGF) is elevated in many patients with MEN 1 and may play a pathogenetic role.
Hoang-Xuan
T
T
Departments of Dermatology and Clinical Research, Naval Medical Center, San Diego, California 92134-1005, USA. Hoangxuan@pol.net
Steger
J W
JW
D000236:Adenoma / Q000150:complications / Q000473:pathology; D000328:Adult; D018322:Angiofibroma / Q000150:complications* / Q000473:pathology; D005145:Face; D006801:Humans; D008297:Male; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000473:pathology; D010911:Pituitary Neoplasms / Q000150:complications; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology