A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N).
We report herein the identification of a new HLA-A null allele. This allele, A*0105N, was detected during histocompatibility testing of a cord blood donor and the respective mother. Serologic typing results contrasted those obtained with DNA typing that alone showed the presence of HLA-A*01. ThisA*0105N was due to a nucleotide deletion in exon 4 that altered the reading frame, causing a premature termination.
Poli
F
F
Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milan, Italy. nitpmi@polic.cilea.it
Bianchi
P
P
Scalamogna
M
M
Crespiatico
L
L
Ghidoli
N
N
Puglisi
G
G
Sirchia
G
G
D000483:Alleles; D001483:Base Sequence; D004247:DNA; D005091:Exons / Q000235:genetics*; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D017384:Sequence Deletion
D015234:HLA-A Antigens; C403924:HLA-A*01:04N antigen; D015788:HLA-A1 Antigen; D004247:DNA