title: [Hypophyseal-hypothalamo-thyroid axis in affective disorders].
abstract: For centuries there has been convincing evidence that diseases of the thyroid gland may produce psychiatric symptoms. Nowadays systematic data are available concerning a higher incidence of thyroid diseases in psychiatric patients and vice versa a higher incidence of psychiatric disorders in thyroid patients. A more subtle approach concerns challenge tests like the TRH test. It could be shown that depressive patients show a blunted TSH response to TRH in 30-40% of the cases. This might lead to a definition of a subgroup of depressives from a psychoneuroendocrinological point of view. But it also might have an impact on the prediction of treatment outcome in psychopharmacological treatment approaches.
authors.affiliation: Universitätsklinik für Psychiatrie, Graz. p.hofmann@kfunigraz.ac.at
authors.forename: P
authors.initials: P
authors.lastname: Hofmann
authors.forename: K H
authors.initials: KH
authors.lastname: Schrötter
mesh_terms: D001008:Anxiety Disorders / Q000175:diagnosis / Q000503:physiopathology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D011379:Prognosis; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin