A nonhealing ulcer diagnosed as extramedullary plasmocytoma of the limb eight years after cardiac transplantation.
A 63-year-old man was hospitalized for a nonhealing ulcer of the left lower leg that appeared 8 years after orthotopic cardiac transplantation under immunosuppressive therapy including cyclosporine. Serum protein electrophoresis, immunofixation, and urinalysis revealed a monoclonal gammopathy IgG kappa. The final diagnosis of an extramedullary plasmocytoma was made by biopsy of the ulcer, which showed formations of plasmablastic cells. We report a rare case of extramedullary plasmocytoma as a posttransplantational malignancy.
Ibe
W
W
Department of Medicine II, Johannes Gutenberg University, Mainz, Germany. Ibe@main.uni-mainz.de
Wittlinger
T
T
Sebastian
M
M
Meyer
J
J
Darius
H
H
D016572:Cyclosporine / Q000627:therapeutic use; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology / Q000473:pathology*; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007871:Leg Ulcer / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis*
D007166:Immunosuppressive Agents; D016572:Cyclosporine