title: Effects of predeposit and intentional perioperative haemodilution on blood saving program in major orthopaedic surgery.
abstract: In this study we evaluated the effects of predeposit and intentional perioperative haemodilution on a blood saving program in major orthopaedic surgery. We demonstrated that autologous blood phlebotomy and maintenance of optimal levels of perioperative haemodilution by delaying blood transfusion, even autologous, are efficient techniques in reducing homologous, red blood cell (HRBC) transfusion. Patients who received autologous red blood cell (ARBC) or HRBC more than one day after surgery, while having Hb values <8 g/dl, are less at risk of needing the first or additional HRBCs. In conclusion, predeposit and intentional haemodilution obtained by delaying blood transfusions, even autotransfusional, is a correct way of conducting a blood saving program (BSP) in major orthopaedic surgery. These techniques are clinically effective in avoiding or reducing HRBC transfusion.
authors.affiliation: Anaesthesia and Intensive care Unit, Orthopaedic and Trauma Center, Torino, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Burbi
authors.forename: C
authors.initials: C
authors.lastname: Gregoretti
authors.forename: B
authors.initials: B
authors.lastname: Borghi
authors.forename: E
authors.initials: E
authors.lastname: Pignotti
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D019645:Arthroplasty, Replacement, Knee / Q000379:methods; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001803:Blood Transfusion / Q000379:methods; D001804:Blood Transfusion, Autologous; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects; D011184:Postoperative Period; D011300:Preoperative Care; D011446:Prospective Studies; D016896:Treatment Outcome