Development of a predictive statistical model for the analgesic activity of a family of imides.
Quantitative structure-activity relationship (QSAR) studies were done with a family of cyclic imides. Promising efforts to create a QSAR model with substantial predictive power for the design of novel cyclic imides with improved analgesic activity are reported.
Andricopulo
A D
AD
Departamento de Química, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.
Yunes
R A
RA
Cechinel Filho
V
V
Nunes
R J
RJ
Frazer
J W
JW
Cordes
E H
EH
D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D007094:Imides / Q000737:chemistry* / Q000494:pharmacology*; D015233:Models, Statistical; D008962:Models, Theoretical; D013329:Structure-Activity Relationship
D000700:Analgesics; D007094:Imides