Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors.
A novel series of hydroxamate/urea-based inhibitors of gelatinases has been discovered via solid-phase combinatorial chemistry. SAR of P1', P2', and P3' has been exploited and structures different from traditional succinate-based MMP inhibitors have been found.
Zhang
Y
Y
Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, 53706, USA.
Li
D
D
Houtman
J C
JC
Witiak
D T
DT
Seltzer
J
J
Bertics
P J
PJ
Lauhon
C T
CT
D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D014508:Urea / Q000031:analogs & derivatives*
D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D014508:Urea