[Heterochromatin and single-strand DNA breaks (a hypothesis)].
A hypothesis is put forward which explains the known heterochromatin properties: dense DNA packing, transcriptional inactivity, a tendency for aggregation (adhesiveness) and ectopic contacts. The basic assumption of the hypothesis is that the DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with the same or similar base sequence.
Gruzdev
A D
AD
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia. gruzdev@cgi.nsk.su
D000818:Animals; D004249:DNA Damage; D006570:Heterochromatin / Q000235:genetics*; D006801:Humans; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic
D006570:Heterochromatin