title: [The influence of hormone replacement therapy containing transdermal 17-beta estradiol and oral medroxyprogesterone acetate on coagulation and fibrinolysis].
abstract: OBJECTIVE
  The aim of the study was to evaluate some coagulative and fibrinolytic changes in women taking hormone replacement therapy (HRT).
  
  
  METHODS
  In 29 women aged 45-64 years with osteoporosis and climacteric symptoms several fibrinolytic and coagulative parameters were measured. These measurements were performed three times in each women--before and after three and six months of HRT containing transdermal 17 beta-estradiol (50 mg per day) and oral medroxyprogesterone acetate (2.5 mg per day).
  
  
  RESULTS
  PAI-1 (antigen) and factor VII (activity) were decreased significantly during the trial. No other significant modifications in the examined parameters (fibrinogen, antithrombin III, protein C, protein S, thrombin-antithormbin III complexes, t-PA and D-dimers) were detected.
  
  
  CONCLUSIONS
  The hormone replacement therapy can reduce the risk of coronary heart disease thanks to decreased levels of PAI-1 and factor VII. No other changes in coagulation and fibrinolysis were observed during the treatment.
authors.affiliation: Kliniki Chorób Menopauzy ICZMP w Lodzi.
authors.forename: G
authors.initials: G
authors.lastname: Stachowiak
authors.forename: D
authors.initials: D
authors.lastname: Owczarek
authors.forename: I
authors.initials: I
authors.lastname: Połać
authors.forename: T
authors.initials: T
authors.lastname: Pertyński
authors.forename: S
authors.initials: S
authors.lastname: Jedrzejczyk
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D001777:Blood Coagulation / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000494:pharmacology*; D008875:Middle Aged; D045167:Progesterone Congeners / Q000494:pharmacology*
chemical_list: D045167:Progesterone Congeners; D004958:Estradiol; D017258:Medroxyprogesterone Acetate