Antioxidant principles from Ephemerantha lonchophylla.
One dihydrostilbene and three phenanthrene antioxidants were isolated from an ethanolic extract of the Chinese herbal Ephemerantha lonchophylla. One of these compounds, ephemeranthone (4) is a new natural product. Denbinobin (1) and 3-methylgigantol (3) have been previously isolated from this plant, and 3-ethoxy-5-hydroxy-7-methoxy-1,4-phenanthraquinone (2) is an artifact. The structures of these compounds were determined by spectroscopic analysis. The antioxidative activities for inhibiting human low density lipoprotein oxidation in vitro of compounds 1-4 were determined, and only 4 was active (5.3 times that of probucol).
Chen
H Y
HY
National Research Institute of Chinese Medicine, No. 155-1, Sec 2, Li Nung St., Peitou, Taipei, Taiwan, Republic of China.
Shiao
M S
MS
Huang
Y L
YL
Shen
C C
CC
Lin
Y L
YL
Kuo
Y H
YH
Chen
C C
CC
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis
D000975:Antioxidants; D008077:Lipoproteins, LDL