title: Simple chromosome exchanges are not linear with dose.
abstract: OBJECTIVE
  To check whether simple chromosome exchanges are linearly related to radiation dose.
  
  
  METHODS
  Go-irradiated lymphocytes were cultured to produce metaphase preparations. Chromosomes 1 and 2 were painted different colours and the remaining chromosomes counterstained. Cells containing a colour junction involving both chromosomes 1 and 2 were scored fully, so that simple and complex rearrangements were distinguished.
  
  
  RESULTS
  At doses of 2 Gy and below very few complex rearrangements were seen. About 90% of exchanges were simple. At these doses the linear component of the dose-effect curve accounts on average for only approximately 30% of the observed yield.
  
  
  CONCLUSIONS
  There is a square-law dose component to the yield of simple exchanges in addition to the linear term.
authors.affiliation: National Radiological Protection Board, Chilton, Didcot, UK. alan.edwards@nrpb.org.uk
authors.forename: A A
authors.initials: AA
authors.lastname: Edwards
authors.forename: P A
authors.initials: PA
authors.lastname: Hone
authors.forename: J E
authors.initials: JE
authors.lastname: Moquet
authors.forename: D C
authors.initials: DC
authors.lastname: Lloyd
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male