Intoxication due to negative canrenone interference in digoxin drug monitoring.
Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.
Steimer
W
W
Müller
C
C
Eber
B
B
Emmanuilidis
K
K
D000368:Aged; D002192:Canrenone / Q000097:blood*; D004077:Digoxin / Q000097:blood* / Q000506:poisoning*; D004347:Drug Interactions; D016903:Drug Monitoring / Q000379:methods*; D017248:Enzyme Multiplied Immunoassay Technique; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008508:Medication Errors; D009102:Multiple Organ Failure / Q000209:etiology; D018805:Sepsis / Q000150:complications; D013148:Spironolactone / Q000097:blood*
D013148:Spironolactone; D004077:Digoxin; D002192:Canrenone