title: Effects of misoprostol on lipoprotein (a) levels of ovariectomized rats.
abstract: OBJECTIVE
  To determine the effects of misoprostol on plasma lipoprotein (a) concentrations of ovariectomized rats.
  
  
  METHODS
  Controlled prospective study.
  
  
  METHODS
  Animal research laboratory.
  
  
  METHODS
  Four-month-old female Sprague-Dawley rats.
  
  
  METHODS
  Blood samples were obtained before and 60 days after ovariectomy, and the rats were divided into three groups. Group I (five rats) was treated with vehicle (water); groups II and III (nine and eight rats, respectively) were treated with oral misoprostol at 100 and 200 microg/kg/d, respectively, for 60 days, after which blood was drawn again.
  
  
  METHODS
  Serum lipoprotein (a) levels.
  
  
  RESULTS
  The median lipoprotein (a) level before ovariectomy was 10.8 mg/dL (range, 10.6-46.5 mg/dL). Sixty days after ovariectomy, the level increased significantly to 15.9 mg/dL (range, 10.6-36.9 mg/dL). After treatment, there was no change in lipoprotein (a) levels in the vehicle-treated group (range, 16.3-21.1 mg/dL); however, the lipoprotein (a) levels decreased significantly in the group treated with 100 microg/kg/d of misoprostol, from 15.4 mg/dL to 10.8 mg/dL, and in the group treated with 200 microg/kg/d of misoprostol, from 17.1 mg/dL to 10.6 mg/dL.
  
  
  CONCLUSIONS
  Misoprostol caused a significant decrease in lipoprotein (a) levels.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Ozal Medical Center, Malatya, Turkey. suhas@aidata.net.tr
authors.forename: A S
authors.initials: AS
authors.lastname: Sonmez
authors.forename: M
authors.initials: M
authors.lastname: Birincioğlu
authors.forename: Y
authors.initials: Y
authors.lastname: Turkoz
authors.forename: B
authors.initials: B
authors.lastname: Adam
authors.forename: D
authors.initials: D
authors.lastname: Lurie
authors.forename: C J
authors.initials: CJ
authors.lastname: Chuong
mesh_terms: D000818:Animals; D005260:Female; D017270:Lipoprotein(a) / Q000097:blood*; D016595:Misoprostol / Q000494:pharmacology*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017270:Lipoprotein(a); D016595:Misoprostol