Predicting protein structure using only sequence information.
This paper presents results of blind predictions submitted to the CASP3 protein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model-based method for constructing protein family profiles. The method is purely sequence-based, using no structural information, and yet was able to predict structures as well as all but five of the structure-based methods in CASP3.
Karplus
K
K
John Baskin School of Engineering, University of California, Santa Cruz 95064, USA. karplus@cse.ucsc.edu
Barrett
C
C
Cline
M
M
Diekhans
M
M
Grate
L
L
Hughey
R
R
D000465:Algorithms; D000595:Amino Acid Sequence; D008390:Markov Chains; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
D011506:Proteins