[The anti-arrhythmia activity of new dicyclohexylamide derivatives of N-substituted alpha-aminocarboxylic acids].
Experiments on arrhythmia models showed a high antiarrhythmic activity of new derivatives of dicyclohexylamides of N-replaced alpha-aminocarbonic acids. The new compounds surpassed in intensity and duration of the antiarrhythmic effect the standard agents with classes I and III antiarrhythmic activity. In doing so they raise myocardial electrical stability and prevent sudden development of ventricular fibrillation. According to the mechanism of the antiarrhythmic activity, the new compounds may be related to antiarrhythmic agents possessing the properties of classes I and III.
Berdiaev
S U
SU
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Paliani-Katsitadze
N Sh
NSh
Turilova
A I
AI
Kaverina
N V
NV
Likhosherstov
A M
AM
Lebedeva
A S
AS
Ogurtsov
V A
VA
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D017609:Barium Compounds; D002415:Cats; D002712:Chlorides; D003514:Cyclohexylamines / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007928:Lethal Dose 50; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011189:Potassium Chloride; D011817:Rabbits; D011896:Rana temporaria; D051381:Rats; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D017609:Barium Compounds; D002712:Chlorides; D003514:Cyclohexylamines; C024986:barium chloride; D011189:Potassium Chloride; D000157:Aconitine