title: Comparison of effect of intracanal use of ketorolac tromethamine and dexamethasone with oral ibuprofen on post treatment endodontic pain.
abstract: The purpose of this study was to compare the pain-reducing efficacy of dexamethasone and ketorolac tromethamine when used as an intracanal medication, with oral ibuprofen and a placebo. An additional objective was to establish if any relationship exists between the incidence and severity of pretreatment pain and the incidence and severity of postinstrumentation pain. A total of 48 patients who presented to the University of Illinois postgraduate endodontic clinic were invited to participate. Patients were randomly assigned to 1 of 4 groups: oral ibuprofen, placebo, dexamethasone, or ketorolac tromethamine. Patients were asked to evaluate their pretreatment pain when they presented to the clinic with a Visual Analog Scale. The root canal treatment was performed in two appointments. The first appointment consisted of cleansing and shaping of the canal/s and placement of an intracanal medication. All teeth were closed with a sterile cotton pellet and IRM. Each patient was sent home with a Visual Analog Scale to fill out at 6, 12, 24 and 48 h after initiation of therapy. At the 12-h period, both dexamethasone and ketorolac provided statistically significant better pain relief than placebo. At the 24-h period, only ketorolac demonstrated better pain relief than the placebo. There were no statistically significant differences among the groups at 6 and 48 h. Although ibuprofen pain ratings were less than the placebo at all time points, the reduction was not significant. In addition, no significant differences were demonstrated between ibuprofen and either dexamethasone or ketorolac.
authors.affiliation: Department of Endodontics, University of Illinois, Chicago College of Dentistry, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rogers
authors.forename: B R
authors.initials: BR
authors.lastname: Johnson
authors.forename: N A
authors.initials: NA
authors.lastname: Remeikis
authors.forename: E A
authors.initials: EA
authors.lastname: BeGole
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D020911:Ketorolac Tromethamine / Q000627:therapeutic use*; D008875:Middle Aged; D010147:Pain Measurement; D018915:Root Canal Preparation / Q000009:adverse effects*; D014098:Toothache / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D020911:Ketorolac Tromethamine; D003907:Dexamethasone; D007052:Ibuprofen