title: c-fos gene expression parallels auditory adaptation in the adult rat.
abstract: This study investigated the pattern of c-fos gene expression corresponding with auditory adaptation to novel sound. Using six groups of adult rats (naive control, 1 h, and 1, 2, 3, and 4 days of continuous stimulation), we quantified c-fos expressing cells in the dorsal and ventral cochlear nuclei and found a 54 fold increase in 1 h following novel sound stimuli. The number of reactive cells decreased sharply within 24 h and nearly disappeared by 96 h. Our results reveal that c-fos gene expression in the adult rat is attenuated in parallel with the expected auditory adaptation to novel sounds indicating an association with auditory learning and memory.
authors.affiliation: Department of Otolaryngology, New York, University Medical Center, NY 10016, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kandiel
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: D E
authors.initials: DE
authors.lastname: Hillman
mesh_terms: D000161:Acoustic Stimulation; D000222:Adaptation, Physiological / Q000502:physiology*; D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D017626:Cochlear Nucleus / Q000737:chemistry / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D005260:Female; D015870:Gene Expression / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D008568:Memory / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D051381:Rats
chemical_list: D016760:Proto-Oncogene Proteins c-fos