title: Synthesis and antitumor activity of goniofufurone analogues.
abstract: Synthesis and antitumor activity of goniofufurone analogues 15, 16, 17, 33, and 46 is reported. Key step in the synthesis is Pd (II) mediated oxidative cyclisation of vinyl-(hydroxy) furans 18, 19 to the corresponding lactols 32, 43. Cytotoxicities of 15, 16, 17, 33, and 46 tested against six human cancer cell lines are reported. Change of stereochemistry at C-5, C-6 and C-7 position of goniofufurone (1) did not enhance the cytotoxicities significantly.
authors.affiliation: Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad. root@csiict.ren.nic.in
authors.forename: H B
authors.initials: HB
authors.lastname: Mereyala
authors.forename: R R
authors.initials: RR
authors.lastname: Gadikota
authors.forename: M
authors.initials: M
authors.lastname: Joe
authors.forename: S K
authors.initials: SK
authors.lastname: Arora
authors.forename: S G
authors.initials: SG
authors.lastname: Dastidar
authors.forename: S
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; C073080:7-goniofufurone