Formaldehyde generation by N-demethylation.
Microsomal oxidation of exogenic compounds yields efferent metabolites with small molecular size. N-demethylation results in formaldehyde generation in addition to the nor-compound. Interesting changes in the level of formaldehyde elimination were observed after a single dose of either ( )-deprenyl or (+)-deprenyl. Urine elimination of the generated formaldehyde was determined using thin-layer chromatography after derivatization with dimedone.
Kalász
H
H
Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary. KalHub@net.sote.hu
Báthori
M
M
Tyihák
E
E
D005557:Formaldehyde / Q000652:urine*; D006801:Humans; D008297:Male; D008745:Methylation; D012642:Selegiline / Q000008:administration & dosage* / Q000493:pharmacokinetics
D005557:Formaldehyde; D012642:Selegiline