Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival.
The details of nuclear transport mechanisms are emerging rapidly, largely through work with model organisms. Here, we briefly describe these advances, with an emphasis on the remaining challenges. We then address the nuclear transport of some high profile cellular regulators, including p53 and the proto-oncogene PKB/Akt. We discuss the mechanisms that contribute to the differential subcellular localization of these proteins. Finally, we analyse the provocative patterns that emerge from our overview.
Ferrigno
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Department of Cancer Biology, The Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, MA 02115, USA.
Silver
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PA
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001692:Biological Transport; D002467:Cell Nucleus / Q000201:enzymology* / Q000378:metabolism*; D002470:Cell Survival / Q000502:physiology*; D020935:MAP Kinase Signaling System; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D014157:Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt