title: [Intralesional injection of vinblastine in treatment of laryngeal Kaposi sarcoma associated with AIDS].
abstract: Kaposi's sarcoma (KS), is the most frequent malignant neoplasm associated with acquired immunodeficiency syndrome (AIDS). Classically arising in the skin, mucosal lesions are seen in 50 percent in oral cavity. KS rarely involves the larynx (37 cases have been reported in the world literature), when KS occurs in the larynx airway compromise can be a serious threat and immediate treatment is necessary. We report one case of KS of the supraglottic larynx, and intralesional injections were performed. A complete response was noted eleven months later. Although several modes of treatment are available (radiation therapy, systemic chemotherapy) to manage KS, intralesional injections with vinblastine sulfate may after an effective therapeutic alternative.
authors.affiliation: Fédération d'ORL, CHU Timone, Marseille.
authors.forename: R
authors.initials: R
authors.lastname: Gras
authors.forename: G
authors.initials: G
authors.lastname: Moulin
authors.forename: A
authors.initials: A
authors.lastname: Giovanni
authors.forename: C
authors.initials: C
authors.lastname: Chagnaud
authors.forename: J M
authors.initials: JM
authors.lastname: Triglia
authors.forename: M
authors.initials: M
authors.lastname: Zanaret
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017320:HIV Protease Inhibitors; D014747:Vinblastine