The baboon as a non-human primate model of human schistosome infection.
Over the past three decades, intensive studies of murine schistosomiasis have provided important clues to the understanding of the human disease, but growing evidence suggests that these results derived from highly inbred strains of mice might not have direct applicability to the human infection. Recent data based on the baboon indicate that infection in this non-human primate might mirror the human situation. In this review, Mramba Nyindo and Idle Farah demonstrate that baboons provide an excellent non-human primate model that produces pathology and disease closely resembling that observed in humans, and address how studies in baboons can provide insights into mechanisms regulating schistosomiasis mansoni pathology and immunity. They also address, in a general way, issues related to the use of non-human primates in biomedical research.
Nyindo
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Kilimanjaro Christian Medical College (KCMC), Tumaini University, PO Box 2240, Moshi, Tanzania. kcmc@eoltz.com
Farah
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D000827:Animal Welfare; D000818:Animals; D000953:Antigens, Protozoan / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006801:Humans; D008099:Liver / Q000473:pathology; D051379:Mice; D008992:Monkey Diseases / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D010215:Papio / Q000276:immunology / Q000469:parasitology*; D010270:Parasite Egg Count / Q000662:veterinary; D012550:Schistosoma mansoni / Q000276:immunology / Q000472:pathogenicity*; D012552:Schistosomiasis / Q000276:immunology* / Q000473:pathology
D000953:Antigens, Protozoan