A multicenter U.S. experience with EUS-guided fine-needle aspiration using the Olympus GF-UM30P echoendoscope: safety and effectiveness.
BACKGROUND
The aim of this study was to determine the safety, efficacy, and accuracy of endoscopic ultrasound (EUS)-guided fine-needle aspiration using the GF-UM30P echoendoscope.


METHODS
GF-UM30P-guided EUS-guided fine-needle aspiration results from 3 EUS referral centers were prospectively recorded. Successful sampling required that the needle tip be seen within the lesion on at least 1 pass. Aspirates were considered adequate if they were diagnostic for cancer, contained suspicious or atypical cells, or were adequately cellular for interpretation but nondiagnostic.


RESULTS
EUS-guided fine-needle aspiration was attempted on 162 lesions in 152 patients with no complications. Sampling was successful in 150 of 162 (93%) attempts (mean lesion size 2.5 +/- 1.2 cm (range 0.7 to 6.0 cm). Aspirates were adequately cellular in 138 of 162 (85%) attempts (43% diagnostic, 15% suspicious and/or atypical cells, 27% adequate cellularity but nondiagnostic). Sampling failed in 12 of 162 (7%) attempts. Ten of 12 (83%) failures and 11 of 12 (92%) inadequate aspirates occurred when lesions measured less than 2 cm. The sensitivity for malignancy was 93% if only successfully sampled lesions with surgically confirmed negative results were included. However, it was 68% if all attempts were included and when unconfirmed high/moderate suspicion negative results were counted as false negatives and low suspicion negative results as true negatives.


CONCLUSIONS
The GF-UM30P may be clinically useful for EUS-guided fine-needle aspiration if a curved linear array instrument is unavailable.
Sahai
A V
AV
Digestive Disease Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Schembre
D
D
Stevens
P D
PD
Chak
A
A
Isenberg
G
G
Lightdale
C J
CJ
Sivak
M V
MV
Hawes
R H
RH
D001707:Biopsy, Needle / Q000295:instrumentation*; D004064:Digestive System / Q000000981:diagnostic imaging / Q000473:pathology; D019723:Endoscopes; D019160:Endosonography / Q000295:instrumentation*; D004867:Equipment Design; D004869:Equipment Safety; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D011446:Prospective Studies; D012680:Sensitivity and Specificity