Vitamin D and regulation of gene expression.
The function of 1,25-dihydroxyvitamin D3, the biologically active form of vitamin D, extends from bone and mineral homeostasis to the control of cell growth and differentiation in a variety of tissues. Most of these actions are mediated by activation of the nuclear vitamin D receptor, which regulates the transcription of vitamin D target genes. Considerable progress has been made in the understanding of vitamin D receptor function (especially regarding its interaction with coactivators), as well as in the identification of novel vitamin D responsive genes related to cell growth, differentiation and cytokine production.
Segaert
S
S
Laboratory for Experimental Medicine and Endocrinology, Faculty of Medicine, Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
Bouillon
R
R
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology*
D014807:Vitamin D; D002117:Calcitriol