Antiretroviral therapy in primary HIV.
Initiation of antiretroviral therapy during primary HIV-1 infection may well redefine the course of the disease by controlling the burst of viral replication and subsequent immune dysfunction. At present, treatment of acute primary HIV-1 should remain largely in the domain of clinical investigation. There are significant problems in providing constant vigilance to medication and subsequent viral suppression. Only clinical trials can define the relative benefit of initiating antiretrovirals during this stage of infection.
Corey
L
L
Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, University of Washington, Seattle 98109-1024, USA.
Berrey
M M
MM
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000821:virology; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D017735:Virus Latency
D019380:Anti-HIV Agents