Remodeling of an acellular collagen graft into a physiologically responsive neovessel.
Surgical treatment of vascular disease has become common, creating the need for a readily available, small-diameter vascular graft. However, the use of synthetic materials is limited to grafts larger than 5-6 mm because of the frequency of occlusion observed with smaller-diameter prosthetics. An alternative to synthetic materials would be a biomaterial that could be used in the design of a tissue-engineered graft. We demonstrate that a small-diameter (4 mm) graft constructed from a collagen biomaterial derived from the submucosa of the small intestine and type I bovine collagen has the potential to integrate into the host tissue and provide a scaffold for remodeling into a functional blood vessel. The results obtained using a rabbit arterial bypass model have shown excellent hemostasis and patency. Furthermore, within three months after implantation, the collagen grafts were remodeled into cellularized vessels that exhibited physiological activity in response to vasoactive agents.
Huynh
T
T
Vascular Biology and Atherosclerosis Research, Duke University Medical Center, Durham NC 27710, USA.
Abraham
G
G
Murray
J
J
Brockbank
K
K
Hagen
P O
PO
Sullivan
S
S
D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D002339:Carotid Arteries / Q000601:surgery*; D002417:Cattle; D003094:Collagen; D006085:Graft Survival; D007422:Intestines / Q000737:chemistry; D011817:Rabbits; D013552:Swine
D001672:Biocompatible Materials; D003094:Collagen