[The inhibition by interferon type I of the initial phase of experimental salmonellosis].
Using the bacteriological methods the level of the genus Salmonella representative histadhesion to intestinal mucosa was evaluated. Balb/c mice and Salmonella typhimurium 415 strain were used for investigation. Native homologous I type interferon was injected to experimental animals 24 before the experiment in a dose of 1000 U/mice. "False" interferon was administered to the control group animals. It was established that the level of Salmonella histadhesion in mice of the experimental group was an order less than in control. Study of the parameters of the process of Salmonella interaction with intestinal mucosa showed that the challenge dose of Salmonella typhimurium 24 after interferon injection must be 7 times higher for the control mice than for experimental ones. Thus, the barrier function of intestinal mucosa after administration of the native I type interferon in vivo increased 7 times.
Fil'chakov
I V
IV
Kyiv Scientific-Research Institute of Epidemiology and Infectious Diseases, Ministry of Public Health of Ukraine.
Zhalko-Titarenko
V P
VP
Zaritskiĭ
A M
AM
Chernikova
M Iu
MIu
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007370:Interferon Type I / Q000494:pharmacology / Q000627:therapeutic use*; D007421:Intestine, Small / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors
D000900:Anti-Bacterial Agents; D007370:Interferon Type I