Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents.
Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S1' pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P1' 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs.
Bailey
S
S
SmithKline Beecham Pharmaceuticals, UK.
Bolognese
B
B
Faller
A
A
Louis-Flamberg
P
P
MacPherson
D T
DT
Mayer
R J
RJ
Marshall
L A
LA
Milner
P H
PH
Mistry
J
J
Smith
D G
DG
Ward
J G
JG
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D017455:Receptors, IgE / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001643:Bridged Bicyclo Compounds; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D017455:Receptors, IgE