title: In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp.
abstract: The in vitro antimicrobial susceptibilities of isolates of Burkholderia mallei to 16 antibiotics were assessed and compared with the susceptibilities of Burkholderia pseudomallei and Burkholderia cepacia. The antibiotic susceptibility profile of B. mallei resembled that of B. pseudomallei more closely than that of B. cepacia, which corresponds to their similarities in terms of biochemistry, antigenicity, and pathogenicity. Ceftazidime, imipenem, doxycycline, and ciprofloxacin were active against both B. mallei and B. pseudomallei. Gentamicin was active against B. mallei but not against B. pseudomallei. Antibiotics clinically proven to be effective in the treatment of melioidosis may therefore be effective for treating glanders.
authors.affiliation: CBD Porton Down, Salisbury, Wilts SP4 OJQ, United Kingdom.
authors.forename: D J
authors.initials: DJ
authors.lastname: Kenny
authors.forename: P
authors.initials: P
authors.lastname: Russell
authors.forename: D
authors.initials: D
authors.lastname: Rogers
authors.forename: S M
authors.initials: SM
authors.lastname: Eley
authors.forename: R W
authors.initials: RW
authors.lastname: Titball
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019117:Burkholderia / Q000187:drug effects*; D019121:Burkholderia Infections / Q000382:microbiology*; D016957:Burkholderia pseudomallei / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011786:Quality Control
chemical_list: D000900:Anti-Bacterial Agents