title: Lack of association of Helicobacter pylori infection with gastric hypersensitivity or delayed gastric emptying in functional dyspepsia.
abstract: OBJECTIVE
  We evaluated the relationship between Helicobacter pylori (H. pylori) infection and gastric sensitivity to distention or gastric emptying rate to define the role of H. pylori in the pathogenesis of functional dyspepsia.
  
  
  METHODS
  Gastric barostat, gastric emptying scintigraphy, and 13C urea breath test were performed in 34 consecutive patients with functional dyspepsia.
  
  
  RESULTS
  Between H. pylori-positive and -negative patients with functional dyspepsia, there were no significant differences in basal tone (57.2 +/- 15.0 ml vs 66.8 +/- 18.3 ml), compliance (41.0 +/- 11.2 ml/mm Hg vs 38.2 +/- 11.8 ml/mm Hg), threshold of first sense (3.6 +/- 2.7 mm Hg vs 2.3 +/- 1.5 mm Hg), threshold of abdominal discomfort (9.4 +/- 4.0 mm Hg vs 7.3 +/- 1.9 mm Hg), and postprandial receptive relaxation (115.4 +/- 89.7 ml vs 99.0 +/- 88.7 ml), measured by gastric barostat. Half gastric emptying time (88.6 +/- 24.5 min vs 91.4 +/- 21.6 min) and retention rate at 120 min (32.8 +/- 17.8% vs 41.9 +/- 20.1%) were also similar between the two groups.
  
  
  CONCLUSIONS
  H. pylori infection was not associated with gastric hypersensitivity to distention or delayed gastric emptying.
authors.affiliation: Division of Gastroenterology, Samsung Medical Center, Sung-kyun-kwan University School of Medicine, Seoul, Korea.
authors.forename: P L
authors.initials: PL
authors.lastname: Rhee
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Son
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Koh
authors.forename: S W
authors.initials: SW
authors.lastname: Paik
authors.forename: J C
authors.initials: JC
authors.lastname: Rhee
authors.forename: K W
authors.initials: KW
authors.lastname: Choi
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000368:Aged; D001944:Breath Tests; D002247:Carbon Isotopes; D004415:Dyspepsia / Q000209:etiology*; D004435:Eating; D005260:Female; D013271:Gastric Dilatation / Q000209:etiology / Q000503:physiopathology; D005746:Gastric Emptying / Q000502:physiology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000502:physiology; D010528:Peristalsis / Q000502:physiology; D011312:Pressure; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012527:Satiation / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D013270:Stomach / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors; D014508:Urea / Q000032:analysis
chemical_list: D002247:Carbon Isotopes; D019275:Radiopharmaceuticals; D014508:Urea; D016284:Technetium Tc 99m Pentetate