Effect of homocysteine on the production of nitric oxide in endothelial cells.
1. Homocysteine decreased the release of nitric oxide in cultured human umbilical vein endothelial cells. 2. Homocysteine did not affect constitutive and inducible nitric oxide synthase activity.
Chow
K
K
Department of Pharmacology, Faculty of Medicine, University of Hong Kong, SAR China.
Cheung
F
F
Lao
T T
TT
O
K
K
D002461:Cell Line, Transformed; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D006710:Homocysteine / Q000494:pharmacology*; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III
D006710:Homocysteine; D009569:Nitric Oxide; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III