Receptor-Ck regulates the expression of cyclin-dependent kinase inhibitors (p16; p27).
The present study was addressed to understand the interrelationship between Receptor-Ck induction-activation coupling; isoprenoids (derived from mevalonate pathway) and cyclin-dependent kinase inhibitors. The results reported here unambiguously reveal that isoprenoids regulate the expression of genes coding for CDK inhibited p16 and p27. Further, Receptor-Ck dependent signalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-Ck has an important role in the regulation of cell cycle machinery.
Kaul
D
D
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Kaur
M
M
D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D018797:Cell Cycle Proteins; D002784:Cholesterol / Q000378:metabolism; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000378:metabolism; D005786:Gene Expression Regulation; D018922:HL-60 Cells; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000235:genetics; D018110:Receptors, Lipoprotein / Q000378:metabolism; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D008869:Microtubule-Associated Proteins; D018110:Receptors, Lipoprotein; D025521:Tumor Suppressor Proteins; C113493:receptor-Ck; D050760:Cyclin-Dependent Kinase Inhibitor p27; D002784:Cholesterol; D018844:Cyclin-Dependent Kinases; D008798:Mevalonic Acid