Anaphylactic shock reaction to dibutyl-phthalate-containing capsules.
We report on a patient who was taking a Gelomyrtol forte capsule, a mucosecretolytic herbal product, to treat an infection of the upper respiratory tract. Itching, urticaria and respiratory distress occurred after 20 min which culminated in anaphylactic shock. Prick tests were carried out with the individual substances from Gelomyrtol forte capsules. Dibutyl phthalate produced a strong positive result. It is used as a plasticizer in films covering tablets, dragées and capsules. As a triggering agent of anaphylactic reactions to drugs, the auxiliary materials, e.g. dibutyl phthalate, should also be taken into consideration.
Gall
H
H
Department of Dermatology, University of Ulm, Germany.
Köhler
A
A
Peter
R U
RU
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D003993:Dibutyl Phthalate / Q000009:adverse effects*; D004338:Drug Combinations; D006801:Humans; D008610:Menthol / Q000009:adverse effects / Q000031:analogs & derivatives*; D010936:Plant Extracts / Q000009:adverse effects; D012882:Skin Tests; D013729:Terpenes / Q000009:adverse effects*
D004338:Drug Combinations; D010936:Plant Extracts; D013729:Terpenes; C016469:gelomyrtol; D008610:Menthol; D003993:Dibutyl Phthalate