title: [Left ventricular myocardial structure and function in patients with primary aldosteronism].
abstract: OBJECTIVE
  To study severity of left ventricular hypertrophy (LVH) and left ventricular function in patients with primary aldosteronism (PA) in comparison with hyperaldosteronemia and preoperative arterial hypertension, to follow the dynamics of these parameters early and late after surgical removal of aldosteroma.
  
  
  METHODS
  Concentration of aldosterone (AC), plasma renin activity (PRA) were measured in 28 PA patients aged 26-58 years before removal of aldosteroma and 1 month, 1 year and 2-5 years after the surgical treatment. Myocardial status was assessed by echocardiography, Doppler echocardiography. 30 healthy subjects aged 25-55 years served control.
  
  
  RESULTS
  All the PA patients showed initial or moderate LVH. Index of left ventricular myocardial mass was influenced at the first regression step by primarily diastolic pressure, at the second step--by basal PRA. The diastolic function was affected. One month after unilateral adrenalectomy PRA level and arterial pressure decreased but regression of LVH was noted only 1 year and later after the surgery. Diastolic function improved 1 year after the operation but without normalization within 2-5-year follow-up.
  
  
  CONCLUSIONS
  The lack of a complete normalization of diastolic function of the left ventricle late after the surgery despite regression of LVH and preoperative correlation of the isometric relaxation time with PRA level may be caused by fibrous changes in the myocardium and by hyperaldosteronemia effects.
authors.forename: G G
authors.initials: GG
authors.lastname: Arabidze
authors.forename: N M
authors.initials: NM
authors.lastname: Chikhladze
authors.forename: L M
authors.initials: LM
authors.lastname: Sergakova
authors.forename: E B
authors.initials: EB
authors.lastname: Iarovaia
mesh_terms: D000315:Adrenalectomy; D000328:Adult; D000450:Aldosterone / Q000097:blood; D001783:Blood Flow Velocity; D001794:Blood Pressure; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D012083:Renin / Q000097:blood; D012720:Severity of Illness Index; D017725:Ventricular Pressure
chemical_list: D000450:Aldosterone; D012083:Renin