Elimination of non-ionic contrast medium by hemodialysis in patients with impaired renal function.
The elimination rate of iohexol, a non-ionic contrast medium, from the blood by hemodialysis, and the elimination rate of iohexol by a dialyzer were studied in 15 patients with chronic renal dysfunction who required angiography or enhanced CT. The elimination rate of iohexol was 19.8% at 15 min after the start of hemodialysis, 30.6% after 30 min, 44.2% after 1 hour, 62.1% after 2 hours and 72.9% after 3 hours. The dialyzer elimination rate was maintained at about 75% from 1 to 3 hours after the start of hemodialysis. If only about 70% of iohexol in the blood needs to be eliminated, hemodialysis for 3 hours with a blood flow rate of 120 ml/min and a dialysate flow of 500 ml/min using a 0.7 m2 cellulose triacetate membrane is sufficient.
Horiuchi
K
K
Department of Urology, Nippon Medical School, Tokyo, Japan.
Yoshida
K
K
Tsuboi
N
N
Akimoto
M
M
Tajima
H
H
Kumazaki
T
T
D003287:Contrast Media / Q000302:isolation & purification* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007472:Iohexol / Q000302:isolation & purification* / Q000493:pharmacokinetics; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D006435:Renal Dialysis; D013997:Time Factors
D003287:Contrast Media; D007472:Iohexol