[Effects of dopexamine on splanchnic perfusion in cardiac surgery].
The present study investigates the effects of dopexamine on the splanchnic perfusion and the general circulation in patients undergoing coronary artery bypass grafting.


METHODS
34 Patients undergoing elective coronary artery bypass grafting were randomized to receive either dopexamine (1 microg/kg/min) or placebo (0,9% NaCl. ) Cardiac output was measured by thermodilution using a pulmonary artery catheter. Splanchnic blood flow was determined by constant infusion technique of indocyanine green dye (ICG) using a hepatic vein catheter.


RESULTS
Under steady state conditions before surgery, dopexamine increased systemic oxygen supply and cardiac output by an increase in heart rate and stroke volume, with no increase in systemic oxygen demand. Before surgery dopexamine increased splanchnic blood flow together with an increase in cardiac output. After cardiopulmonary bypass dopexamine increased splanchnic perfusion without a concomittant rise in cardiac output.


CONCLUSIONS
These results provide evidence that dopexamine improves splanchnic blood flow in patients with coronary artery disease before and after pulmonary bypass without impairment of general hemodynamics.
Bach
F
F
Klinik für Anästhesiologie und Intensivmedizin, Chirurgische Klinik der Universitätskliniken des Saarlandes Homburg/Saar. aifbac@med-rz.uni-sb.de
Silomon
M
M
Grundmann
U
U
Stürner
J
J
Graeter
T
T
Larsen
R
R
D000368:Aged; D002302:Cardiac Output / Q000187:drug effects; D004396:Coloring Agents; D001026:Coronary Artery Bypass; D004298:Dopamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D013152:Splanchnic Circulation / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use*
D004396:Coloring Agents; D014665:Vasodilator Agents; C046318:dopexamine; D007208:Indocyanine Green; D010100:Oxygen; D004298:Dopamine