Alterations of rat liver phospholipid composition induced by oral thalidomide.
In an attempt to elucidate the effects of oral thalidomide on liver phospholipid composition, doses of 1 and 3 mg/kg/day of thalidomide were orally administered to two groups of female Wistar rats (7 animals each), respectively, over a period of 60 days. Control animals (n = 7) received corresponding quantities of the vehicle alone. Chromatographic analysis and quantitative determination of the isolated phospholipid classes revealed statistically significant alterations of phospholipid fractions in the liver of the animals treated with the higher thalidomide dose (3 mg/kg/day). These alterations may be associated with changes in the metabolic activity, ionic transport and cell-cell interactions of the hepatic cellular components.
Kalofoutis
A
A
Department of Biochemistry, University of Athens, Greece.
Monastirli
A
A
Papapanagiotou
A
A
Georgiou
S
S
Pasmatzi
E
E
Sakkis
T
T
Bolsen
K
K
Goerz
G
G
Merk
H F
HF
Tsambaos
D
D
D000284:Administration, Oral; D000818:Animals; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D005260:Female; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013792:Thalidomide / Q000008:administration & dosage / Q000494:pharmacology*
D007917:Leprostatic Agents; D010743:Phospholipids; D013792:Thalidomide