[Regulation of the mouse aggressive behavior (pharmacologic analysis of the GABAergic mechanism)].
Ethological procedures were used to study the effects of GABA-positive drugs on aggression in male albino mice kept in isolation (opponent test). The results revealed several variants of antiaggressive effects of the tested GAB Aergic drugs: 1) antiaggressive, re-socializing of GABAA agonists muscimol (0.125 and 0.5 mg/kg) and THIP (2.0 mg/kg), and GABAB agonist baclofen (2.5-10 mg/kg); 2) antiaggressive, sedative of GABAB agonists baclofen (12.5 mg/kg), phenibut (50-100 mg/kg), and inhibitor of GABA transamininase sodium valproate (100 mg/kg); 3) antiaggressive, anxiogenic for muscimol (1 mg/kg), THIP (5 mg/kg), and sodium valproate (25-50 mg/kg).
Belozertseva
I V
IV
Valdman Institute of Pharmacology, Pavolv State Medical University, St.-Petersburg.
Andreev
B V
BV
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018682:GABA Agents / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D018080:Receptors, GABA-B / Q000187:drug effects* / Q000502:physiology; D012934:Social Isolation
D004791:Enzyme Inhibitors; D018682:GABA Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D000612:4-Aminobutyrate Transaminase