title: Outcomes of high-dose chemotherapy and autologous stem-cell transplantation in stage IIIB inflammatory breast cancer.
abstract: OBJECTIVE
  To evaluate the disease-free survival (DFS) and overall survival (OS), prognostic factors, and treatment-related mortality of women with stage IIIB inflammatory breast cancer (IBC) treated with combined modality therapy (CMT) and high-dose chemotherapy (HDCT) with autologous stem-cell transplantation.
  
  
  METHODS
  Between 1989 and 1997, 47 consecutive patients with stage IIIB IBC were treated with CMT and HDCT and were the subject of this retrospective analysis. Chemotherapy was administered to all patients before and/or after definitive surgery. Neoadjuvant and adjuvant chemotherapy was administered to 33 and 34 patients, respectively, and 20 patients received both. All patients received HDCT with autologous stem-cell transplantation, and 41 patients received locoregional radiation therapy. Tamoxifen was prescribed to patients with estrogen receptor (ER)-positive cancer.
  
  
  RESULTS
  The mean duration of follow-up from diagnosis was 30 months (range, 6 to 91 months) and from HDCT was 22 months (range, 0.5 to 82 months). At 30 months, the Kaplan-Meier estimates of DFS and OS from diagnosis were 57.7% and 59.1%, respectively. At 4 years, the Kaplan-Meier estimates of DFS and OS from diagnosis were 51.3% and 51.7%, respectively. In a multivariate analysis, the only factors associated with better survival were favorable response to neoadjuvant chemotherapy (P =.04) and receipt of tamoxifen (P =.06); however, the benefit of tamoxifen was only demonstrated in patients with ER-positive breast cancer. At last follow-up, 28 patients (59. 6%) were alive and disease-free. Seventeen patients (36.2%) developed recurrent breast cancer. Seventeen patients died: 15 from disease recurrence and two (4.2%) from treatment-related mortality due to HDCT.
  
  
  CONCLUSIONS
  In this analysis, the early results of treatment with CMT and HDCT compare favorably with other series of patients with stage IIIB IBC treated with CMT alone. These outcomes must be confirmed with longer follow-up and controlled studies.
authors.affiliation: Division of Bone Marrow Transplantation, Washington University School of Medicine, St Louis, MO 63110-1093, USA. dadkins@imgate.wustl.edu
authors.forename: D
authors.initials: D
authors.lastname: Adkins
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: K
authors.initials: K
authors.lastname: Trinkaus
authors.forename: R
authors.initials: R
authors.lastname: Maziarz
authors.forename: S
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authors.lastname: Luedke
authors.forename: C
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authors.lastname: Freytes
authors.forename: B
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authors.lastname: Needles
authors.forename: D
authors.initials: D
authors.lastname: Wienski
authors.forename: P
authors.initials: P
authors.lastname: Fracasso
authors.forename: T
authors.initials: T
authors.lastname: Pluard
authors.forename: W
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authors.lastname: Moriconi
authors.forename: T
authors.initials: T
authors.lastname: Ryan
authors.forename: K
authors.initials: K
authors.lastname: Hoelzer
authors.forename: S
authors.initials: S
authors.lastname: Safdar
authors.forename: T
authors.initials: T
authors.lastname: Rearden
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
authors.forename: H
authors.initials: H
authors.lastname: Khoury
authors.forename: R
authors.initials: R
authors.lastname: Vij
authors.forename: J
authors.initials: J
authors.lastname: DiPersio
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000379:methods; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015411:Mastectomy, Modified Radical; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009922:Oregon / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D011878:Radiotherapy; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D013629:Tamoxifen / Q000627:therapeutic use; D013781:Texas / Q000453:epidemiology; D016896:Treatment Outcome; D014861:Washington / Q000453:epidemiology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen