Leukocytoclastic vasculitis following staphylococcal protein A column immunoadsorption therapy for idiopathic thrombocytopenic purpura.
A patient with refractory idiopathic thrombocytopenic purpura developed widespread palpable purpura, fever, diarrhea, and arthralgias forty-eight hours following a third protein A immunoadsorption treatment. A skin biopsy revealed leukocytoclastic vasculitis. His skin lesions and constitutional symptoms resolved with administration of antibiotics and bed rest.
Bourelly
P E
PE
Department of Medicine, Georgetown University Medical Center, Washington, DC, USA.
Grossman
M E
ME
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D007163:Immunosorbent Techniques / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*; D013205:Staphylococcal Protein A / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
D000900:Anti-Bacterial Agents; D013205:Staphylococcal Protein A