title: Brunner's gland metaplasia of residual jejunum developed long after wide resection of the small intestine.
abstract: We report a rare case in which mucous glands, similar to pyloric or Brunner's glands, developed in the residual jejunum (46 cm in length) long after wide resection of the small intestine. The mucous glands were observed in the mucosal and submucosal layers near the duodenum, and the mucin showed a positive reaction by paradoxical concanavalin A staining and immunoreactivity for HIK-1083, which were histochemically the same as those in the pyloric/Brunner's glands. This type of metaplasia in the small intestine without ulceration has not been described in the literature so far. It was speculated that these glands developed as a defense response or adaptation against relatively excessive acid due to the short small intestine.
authors.affiliation: Department of Pathology, Suwa Red Cross Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: J
authors.initials: J
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Katsuyama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002011:Brunner Glands / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007421:Intestine, Small / Q000601:surgery; D007583:Jejunum / Q000378:metabolism / Q000473:pathology*; D008679:Metaplasia / Q000473:pathology; D009077:Mucins / Q000378:metabolism; D009092:Mucous Membrane / Q000378:metabolism
chemical_list: D009077:Mucins