Osteoarthrosis of the temporomandibular joint induced by intra-articular injection of lactate dehydrogenase: an experimental study in adult rabbits.
OBJECTIVE
The purpose of this study was to establish an animal model of osteoarthrosis in the temporomandibular joint (TMJOA) by injecting lactate dehydrogenase (LDH) into the maxillary compartments of TMJs in adult rabbits.


METHODS
Adult New Zealand white rabbits were randomly divided into four groups (A through D) of five animals each. The A and B groups were used as a control. The maxillary compartments of the C and D group (TMJs) were injected with 0.1 mL of LDH in two different concentrations. The TMJ samples were analyzed histologically and with a scanning electron microscope four different times after injection.


RESULTS
The animals that had been injected with LDH at two different concentrations showed similar results. The TMJs had changes typical of OA in early to moderate stages. No pathologic changes could be found in the TMJs of the control groups.


CONCLUSIONS
The results suggest that LDH may be of use in establishing an animal model of TMJOA.
Tian
H
H
Guanghua Stomatology Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou, P. R. China.
Zhang
Z G
ZG
He
Y Q
YQ
Chen
X R
XR
D000818:Animals; D004195:Disease Models, Animal; D007270:Injections, Intra-Articular; D007770:L-Lactate Dehydrogenase / Q000008:administration & dosage / Q000009:adverse effects*; D008855:Microscopy, Electron, Scanning; D010003:Osteoarthritis / Q000201:enzymology* / Q000209:etiology; D011817:Rabbits; D011897:Random Allocation; D013705:Temporomandibular Joint Disorders / Q000201:enzymology* / Q000209:etiology
D007770:L-Lactate Dehydrogenase