title: Experimental analysis of flow calculations based on HRCT imaging of individual bifurcations.
abstract: Flow simulations in airways and arteries allow the non-invasive study of transport and deposition processes in these vessel systems. Individual vessel geometries as input for such simulations are highly desirable. Computed tomography (CT) permits the acquisition of binary data to reconstruct such geometries. To prove the suitability of this reconstruction method, we compared measured with simulated velocities within model bifurcations. Particle image velocimetry was applied to measure flow velocities. Numerical simulations of these velocities were carried out by using the CT data of the same models as input to flow calculations (CFD). Within the resolution limits good agreement between measured and simulated velocities was found. For the smallest bifurcation (tube diameter: 2 mm) the agreement was less, indicating a methodical limitation by the actual resolution of the CT-scan technique. The study showed that a combination of CT and CFD can be considered as an appropriate step towards realistic simulations of particle transportation and deposition in individual geometries of the respiratory or cardiovascular systems.
authors.affiliation: Institute for Inhalation Biology, GSF-National Research Center for Environment and Health, Munich, Germany. tippe@gsf.de
authors.forename: A
authors.initials: A
authors.lastname: Tippe
authors.forename: M
authors.initials: M
authors.lastname: Perzl
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Schulz
mesh_terms: D000465:Algorithms; D001158:Arteries / Q000502:physiology*; D001783:Blood Flow Velocity; D003198:Computer Simulation; D007834:Lasers; D008962:Models, Theoretical; D012212:Rheology; D014057:Tomography, X-Ray Computed