title: Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry.
abstract: Some constituents found in natural flavorings are known to exhibit toxic properties. We developed a rapid method for quantifying 12 flavor-related compounds in cigarette tobacco using headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry. Using selected ion monitoring, we quantified and positively identified coumarin; pulegone; piperonal and nine alkenylbenzenes, including trans-anethole, safrole, methyleugenol and myristicin in one or more brands of cigarettes. In 62% of 68 brands analyzed, we detected one or more of the flavor-related compounds ranging from 0.0018 to 43 microg/g. Toxic properties of these flavor-related compounds may constitute an additional health risk related to cigarette smoking.
authors.affiliation: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Health Laboratory Sciences, Air Toxicants Branch, Atlanta, GA 30341-3724, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Stanfill
authors.forename: D L
authors.initials: DL
authors.lastname: Ashley
mesh_terms: D001555:Benzene Derivatives / Q000302:isolation & purification*; D002138:Calibration; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010947:Plants, Toxic; D012680:Sensitivity and Specificity; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives