title: Coexistent holoprosencephaly and Chiari II malformation.
abstract: Chiari II malformations and holoprosencephaly have been considered to be brain malformations that differ with respect to teratogenic insult, embryologic mechanism, and morphology. We herein describe coexistent Chiari II malformation and holoprosencephaly that occurred in a viable infant. A review of the literature regarding Chiari II malformations and holoprosencephaly suggests that a disturbance to the mesenchyme in early embryologic life may be the cause of both malformations.
authors.affiliation: Department of Radiology, Children's Medical Center and the University of Texas Southwestern Medical School, Dallas 75235, USA.
authors.forename: N
authors.initials: N
authors.lastname: Rollins
authors.forename: J
authors.initials: J
authors.lastname: Joglar
authors.forename: J
authors.initials: J
authors.lastname: Perlman
mesh_terms: D001139:Arnold-Chiari Malformation / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001921:Brain / Q000002:abnormalities / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D016142:Holoprosencephaly / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008591:Meningomyelocele / Q000150:complications / Q000175:diagnosis / Q000473:pathology