Failure of screening to detect HIV in a foreign laborer who died of toxoplasmosis of the central nervous system.
The most common neurologic complication in patients with acquired immunodeficiency syndrome (AIDS) is cerebral toxoplasmosis. Patients with cerebral toxoplasmosis have characteristic findings on clinical examination and neuroimaging. They require prolonged treatment and have a considerable mortality rate. We report a case of cerebral toxoplasmosis in a foreign laborer with AIDS, in whom a human immunodeficiency virus (HIV) screening test failed to detect-HIV infection. The patient, a 23-year-old man from Thailand, presented in a confused state 2 weeks after his arrival in Taiwan. Computed tomography showed a mass effect, and magnetic resonance imaging showed multiple ring-enhanced lesions in the cerebrum. Serologic tests were positive for anti-HIV antibody and also showed high anti-Toxoplasma immunoglobulin G titers. Although symptomatic treatment was initiated, the patient's condition deteriorated rapidly and he died of multiple organ failure due to brain stem herniation a few days after admission. As the number of foreign laborers working in Taiwan has increased dramatically in recent years, the issues raised by this case are the efficacy of our screening protocols for foreign laborers and the increased occupational hazards encountered by medical personnel in Taiwan.
Juan
C W
CW
Department of Medicine, Wellington School of Medicine, University of Otago, New Zealand.
Wu
F F
FF
Chang
W H
WH
Chou
C C
CC
Lee
T C
TC
Lin
J C
JC
D015492:AIDS Serodiagnosis; D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D006801:Humans; D008297:Male; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis*