title: Acid-base balance and substitution fluid during continuous hemofiltration.
abstract: Critically ill patients with acute renal failure usually present with an unstable acid-base balance, often leading to cardiovascular complications and multi-organ failure. Therefore, to prevent metabolic acidosis, acid-base balance must be normalized and maintained; these patients are primarily treated with continuous hemofiltration techniques using different replacement fluids to influence the acid-base values. Dialysate solutions can be an acetate-based, lactate-based, citrate-based or bicarbonate-based buffer. This article discusses the strengths and weaknesses of each type of hemofiltration replacement fluid.
authors.affiliation: Department of Nephrology, Heinrich-Heine-University of Düsseldorf, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Heering
authors.forename: K
authors.initials: K
authors.lastname: Ivens
authors.forename: O
authors.initials: O
authors.lastname: Thümer
authors.forename: M
authors.initials: M
authors.lastname: Braüse
authors.forename: B
authors.initials: B
authors.lastname: Grabensee
mesh_terms: D000136:Acid-Base Equilibrium; D058186:Acute Kidney Injury / Q000628:therapy; D002021:Buffers; D016638:Critical Illness / Q000628:therapy; D015312:Hemodialysis Solutions / Q000737:chemistry / Q000627:therapeutic use*; D006440:Hemofiltration / Q000379:methods*; D006801:Humans
chemical_list: D002021:Buffers; D015312:Hemodialysis Solutions