A new bisabolene epoxide from Tussilago farfara, and inhibition of nitric oxide synthesis in LPS-activated macrophages.
A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed inhibition of nitric oxide synthesis in lipopolysaccharide-activated macrophages.
Ryu
J H
JH
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. ryuha@sdic.sookmyung.ac.kr
Jeong
Y S
YS
Sohn
D H
DH
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008517:Phytotherapy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
C400587:1,5-bisacetoxy-8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D009569:Nitric Oxide