Cytogenetic investigation of transitional cell carcinomas of the upper urinary tract.
Cytogenetic investigation was attempted on 44 tumors from 44 patients with transitional cell carcinoma (TCC) of the upper urinary tract (pelvis and ureter), and karyotypes were obtained in 27 tumors. Numerical changes prevailed, but are not specific for this type of tumor (trisomy 7, -Y, or both). In the light of previously reported data on TCC, the finding of a del(9q) as the only anomaly in one of the cases may be meaningful. Patients showing -Y and/or trisomy 7 had a poor prognosis.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Roskams
T
T
Van Poppel
H
H
Balzarini
P
P
Van den Berghe
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D007682:Kidney Pelvis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014314:Trisomy / Q000235:genetics; D014516:Ureteral Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014998:Y Chromosome / Q000235:genetics