Lack of correlation between surface and interfacial activities of saponins and their hemolytic properties.
For a series of model compounds (digitonin, aescine, tomatine, stevioside and ginsenoside Rg1) it was demonstrated that neither the surface nor the interfacial tension (n-decane/water) lowering properties of saponins can be correlated with their ability to induce hemolysis. Furthermore, no correlation was observed between the surface and interfacial activities of saponins and their hemolytic properties.
Steurer
S
S
Institute of Pharmaceutical Chemistry, University of Graz, Austria.
Wurglics
M
M
Likussar
W
W
Burmistrov
K
K
Michelitsch
A
A
Schubert-Zsilavecz
M
M
D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004910:Erythrocyte Membrane / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013500:Surface Tension
D007202:Indicators and Reagents; D012503:Saponins