Effect of perezone on arrhythmias and markers of cell injury during reperfusion in the anesthetized rat.
In the in vivo rat heart model with transient (5 min) regional ischemia, as induced by left coronary artery ligation, we have demonstrated that perezone reduces dramatically the incidence of reperfusion-induced-arrhythmias. Administered 5 minutes before coronary occlusion, at a dose of 3.1 mg/kg, this drug effectively protects against the high incidence of arrhythmias and the fall of blood pressure. In addition, it inhibits the release of lactic dehydrogenase and creatine-kinase enzymes to the plasma. We propose that the protective effect of perezone might be related to its well documented action of promoting the release of intramitochondrial Ca2+, thus, maintaining ATP production during reperfusion.
Téllez
J F
JF
Departamento de Bioquímica, Instituto Nacional de Cardiologia Ignacio Chávez, Facultad de Medicina UNAM, DF, México.
Carvajal
K
K
Cruz
D
D
Cárabez
A
A
Chávez
E
E
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000201:enzymology / Q000473:pathology* / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000627:therapeutic use*
D015415:Biomarkers; D007527:Isoenzymes; D012717:Sesquiterpenes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; C053752:perezone