Alteration of organized structure of biofilm formed by Staphylococcus epidermidis on soft contact lenses.
The effect of a nonsteroidal antiinflammatory drug commercially available in eye drop form (sodium diclofenac) was assayed for its ability to affect biofilms formed by clinical Staphylococcus epidermidis isolates. Biofilms produced by one strain positive for a slime-associated antigen, suggested to be expressed by more virulent strains, was not affected by sodium diclofenac treatment. On the other hand, biofilm produced by the slime-positive, antigen-negative strain showed dramatic alterations already after short treatments with sodium diclofenac as reported for salicylate and other nonsteroidal drugs. Such results suggest further investigation of the possible use of sodium diclofenac drops in the treatment of ophthalmic infections in soft contact lens wearers.
Perilli
R
R
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
Marziano
M L
ML
Formisano
G
G
Caiazza
S
S
Scorcia
G
G
Baldassarri
L
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000032:analysis; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms; D003263:Contact Lenses, Hydrophilic / Q000382:microbiology*; D004008:Diclofenac / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000942:Antigens, Bacterial; D004008:Diclofenac