title: Design, synthesis and antimuscarinic activity of some imidazolium derivatives.
abstract: A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.
authors.affiliation: Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyachi
authors.forename: H
authors.initials: H
authors.lastname: Kiyota
authors.forename: M
authors.initials: M
authors.lastname: Segawa
mesh_terms: D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000145:classification / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic