title: Parenchymal cell proliferation in coronary arteries after percutaneous transluminal coronary angioplasty: a human tissue bank study.
abstract: OBJECTIVE
  Restenosis after percutaneous transluminal coronary angioplasty (PTCA) remains a limitation of this technique. Arterial wall cell proliferation is a component of restenosis preventable with intravascular brachytherapy. This study attempts to locate the sites of cellular proliferation after PTCA so as to aid the optimization of this therapy.
  
  
  METHODS
  Autopsy records from January 1, 1985 through December 31, 1995 were reviewed, and 27 patients who received PTCA prior to death were identified who also had evidence of PTCA on histologic examination of the arterial sections. The sections were subjected to immunohistochemical staining for proliferating cell nuclear antigen (PCNA) to detect the proliferating cells in the arterial sections, followed by image analysis to determine the proliferative index (PI) of all regions and layers of the section.
  
  
  RESULTS
  The PI did not differ significantly according to vessel region (plaque, plaque shoulder, or portion of vessel wall with lowest plaque burden), vessel layer (intima, media, adventitia), or evidence of prior PTCA. There was a trend toward a higher PI in young lesions.
  
  
  CONCLUSIONS
  Cell proliferation in the vascular wall after PTCA was found throughout the treated arterial section's axial plane, not only in the periluminal region.
authors.affiliation: The Department of Radiation Oncology, The Cleveland Clinic Foundation, OH 44195, USA. ciezki@radonc.ccf.org
authors.forename: J P
authors.initials: JP
authors.lastname: Ciezki
authors.forename: U O
authors.initials: UO
authors.lastname: Häfeli
authors.forename: P
authors.initials: P
authors.lastname: Song
authors.forename: N
authors.initials: N
authors.lastname: Urankar-Nagy
authors.forename: N B
authors.initials: NB
authors.lastname: Ratliff
authors.forename: L
authors.initials: L
authors.lastname: Rybicki
authors.forename: K
authors.initials: K
authors.lastname: Brill
authors.forename: D
authors.initials: D
authors.lastname: Meier
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000032:analysis; D001918:Brachytherapy; D002455:Cell Division; D002467:Cell Nucleus / Q000737:chemistry; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012008:Recurrence; D014654:Vascular Patency
chemical_list: D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen