Recurrent aseptic meningitis following non- steroidal anti-inflammatory drugs--a reminder.
Non-steroidal anti-inflammatory drugs (NSAIDs) are rarely associated with side-effects affecting the central nervous system. A case of NSAID-induced recurrent aseptic meningitis is presented. Seven episodes of aseptic meningitis were documented in the patient's life-time (up to the age of 30). General practitioners' records available for the latest four episodes showed that a NSAID (naproxen, piroxicam or diclofenac) was prescribed in the month prior to admission on each occasion. The patient was symptom free for a 3-year period during which no NSAID was prescribed. Clinicians should always elicit a careful drug history (including over-the-counter medications) in patients with aseptic meningitis and be aware of this unusual side-effect of NSAIDs.
Seaton
R A
RA
Infection and Immunodeficiency Unit, Kings Cross Hospital, Tayside University Hospitals NHS Trust, Dundee DD3 8EA, UK.
France
A J
AJ
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac