[The antioxidant effects of amtizol and trimetazidine].
Experiments were conducted on rats to study the antioxidant effects of amtisol and trimethasidin (25 mg/kg) in incomplete cerebral ischemia complicated by hypoxia. Amtisol as well as trimethasidin inhibited activation of lipid peroxidation (LPO) and prevented decrease in activity of the antioxidant system. In in vitro experiments amtisol and trimethasidin blocked epinephrine auto-oxidation. Amtisol inhibited ascorbate-dependent LPO in the liposomes and metabolizing model system, inhibited fermentative NADP-dependent POL in brain tissue homogenates.
Smirnov
A V
AV
Department of Pharmacology, Russian Federation Military Medical Academy, St. Petersburg, Russia.
Krivoruchko
B I
BI
Zarubina
I V
IV
Mironova
O P
OP
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013830:Thiadiazoles / Q000627:therapeutic use*; D014292:Trimetazidine / Q000627:therapeutic use*
D000975:Antioxidants; D013830:Thiadiazoles; C044365:amtizol; D014292:Trimetazidine; D004837:Epinephrine