Vertebrate development: Multiple phases to endoderm formation.
Recent results support a two-step model for endoderm formation in amphibian embryos, in which endoderm is initially specified by localised maternal factors, including the transcription factor VegT, but is then maintained by extracellular signalling molecules of the transforming growth factor-beta family.
Dale
L
L
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. l.dale@ucl.ac.uk
D000818:Animals; D004625:Embryo, Nonmammalian / Q000502:physiology*; D004707:Endoderm / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014982:Xenopus laevis
D014157:Transcription Factors; D016212:Transforming Growth Factor beta