title: Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene.
abstract: Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for anti-microbial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.
authors.affiliation: Center for Gene Research, Yamaguchi University, Japan. fkishi-ygc@umin.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Kishi
authors.forename: S
authors.initials: S
authors.lastname: Fujishima
authors.forename: M
authors.initials: M
authors.lastname: Tabuchi
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D027682:Cation Transport Proteins; D018900:Dinucleotide Repeats / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D033862:Iron-Binding Proteins; D007564:Japan; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics*; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2
chemical_list: D002352:Carrier Proteins; D027682:Cation Transport Proteins; D033862:Iron-Binding Proteins; D008565:Membrane Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1; D000099236:Solute Carrier Family 11, Member 2