title: Effect of freeze-dried bone and a dextran agglutinant on the healing of defects in the rat mandible.
abstract: The effects of inorganic, freeze-dried bone, alone or mixed with a dextran agglutinant, on the repair of experimentally created critical-size bone defects were evaluated in the rat mandible. Histological data demonstrated a progressive resorption of the freeze-dried bone particles, without osseous proliferation into the defect, and a posterior foreign-body reaction. These results indicate that the freeze-dried bone did not induce bony healing in the critical-size defect and that the addition of dextran agglutinant did not change the tissue response. Dextran may have other applications as a biocompatible, resorbable agglutinant.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, Brazil.
authors.forename: J G
authors.initials: JG
authors.lastname: Luz
authors.forename: J L
authors.initials: JL
authors.lastname: Santiago
authors.forename: R S
authors.initials: RS
authors.lastname: Jorge
authors.forename: V C
authors.initials: VC
authors.lastname: de Araújo
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001862:Bone Resorption; D016025:Bone Transplantation / Q000379:methods*; D003911:Dextrans / Q000494:pharmacology*; D005549:Foreign-Body Reaction / Q000139:chemically induced; D005612:Freeze Drying; D008334:Mandible / Q000503:physiopathology*; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000925:Anticoagulants; D003911:Dextrans