Strong cytotoxic T lymphocyte responses to a macrophage inflammatory protein 1alpha-expressing tumor: linkage between inflammation and specific immunity.
Leukocyte infiltration is an important histological sign of resistance to tumors. However, it is unclear whether local inflammatory responses can promote specific antitumor immunity. Here we report that local expression of macrophage inflammatory protein 1alpha, which results in strong inflammation of leukocytes in tumors, leads to the induction of strong antitumor CTL responses. The induction of CTL effectors requires co-stimulatory molecules B7-1 and/or B7-2 on host antigen-presenting cells but not on the tumors. These results establish a critical linkage between inflammation and specific immunity.
Maric
M
M
Immunobiology Section, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Liu
Y
Y
D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism; D015703:Antigens, CD / Q000502:physiology; D018122:B7-1 Antigen / Q000502:physiology; D051940:B7-2 Antigen; D004354:Drug Screening Assays, Antitumor; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000276:immunology* / Q000378:metabolism*; D019707:Receptors, Chemokine / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497965:Cd86 protein, mouse; D008562:Membrane Glycoproteins; D019707:Receptors, Chemokine; C080633:macrophage inflammatory protein 1alpha receptor