title: A case with intrahepatic double cancer: hepatocellular carcinoma and cholangiocarcinoma associated with multiple von Meyenburg complexes.
abstract: Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) is sometimes found in resected livers, however, cases with double cancer of HCC and CC are very rare. As well, the rarity of CC arising in von Meyenburg complexes (VMCs) is appreciated. We report the case of a 74-year-old man found to have intrahepatic double cancer composed of well-differentiated HCC and CC which exhibited a histologic progression from VMCs to adenomatous lesions and CC. To our knowledge, this is the first case report published in the literature of a double HCC and CC associated with multiple VMCs. The pathogenesis and previous associated reports of these lesions are discussed.
authors.affiliation: Department of Pathology, College of Medicine, Kyung Hee University, Seoul, Korea. kimyw@nms.kyunghee.ac.kr
authors.forename: Y W
authors.initials: YW
authors.lastname: Kim
authors.forename: Y K
authors.initials: YK
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: S W
authors.initials: SW
authors.lastname: Hong
authors.forename: M H
authors.initials: MH
authors.lastname: Yang
mesh_terms: D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology*