Human apolipoprotein A-IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice.
We have investigated the involvement of human apolipoprotein A-IV (apoA-IV) in gastric acid secretion and ulcer formation in recently generated apoA-IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43-77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin-induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA-IV expression can regulate gastric acid secretion and ulcer development.
Vergnes
L
L
Unité d'Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France.
Baroukh
N
N
Léhy
T
T
Moizo
L
L
Bado
A
A
Baralle
M
M
Baralle
F E
FE
Zakin
M M
MM
Ochoa
A
A
D000367:Age Factors; D000818:Animals; D001054:Apolipoproteins A / Q000235:genetics*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D013276:Stomach Ulcer / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D001054:Apolipoproteins A; D005755:Gastrins; C022205:apolipoprotein A-IV; D007213:Indomethacin