title: Contraceptive efficacy of daily administration of 0.5 mg mifepristone.
abstract: The antiprogestin mifepristone has shown potential to be used as a contraceptive. If 200 mg mifepristone is administered immediately after ovulation, the endometrium shows sufficient impairment of secretory development to prevent implantation. Low daily doses of mifepristone have been shown to reduce several of the local factors regarded as crucial for implantation in human endometrium. To find out if this regimen is sufficient to prevent pregnancy, 32 women were recruited for a study where 0.5 mg mifepristone was administered daily. A total of 141 cycles were studied. Five pregnancies occurred, which was significantly less than if no contraceptive method had been used. However, the dose chosen did not seem sufficient to act as a contraceptive although it is probably not possible to increase the dose without disturbing ovulation and bleeding pattern.
authors.affiliation: Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, S-171 76 Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Marions
authors.forename: S
authors.initials: S
authors.lastname: Viski
authors.forename: K G
authors.initials: KG
authors.lastname: Danielsson
authors.forename: B A
authors.initials: BA
authors.lastname: Resch
authors.forename: M L
authors.initials: ML
authors.lastname: Swahn
authors.forename: M
authors.initials: M
authors.lastname: Bygdeman
authors.forename: L
authors.initials: L
authors.lastname: Kovâcs
mesh_terms: D000328:Adult; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D015735:Mifepristone / Q000008:administration & dosage* / Q000009:adverse effects; D010060:Ovulation; D011247:Pregnancy
chemical_list: D003280:Contraceptives, Oral, Synthetic; D015735:Mifepristone