Differential effects of individual trans fatty acid isomers on lipoprotein assembly and metabolism.
Recent findings indicate that certain (t-C18:1 delta 9) but not all (t-C16:1 delta 9 and t-C18:1 delta 11) trans fatty acid isomers influence intestinal lipoprotein secretion. A mechanism is suggested that appears to be sensitive to properties associated not only with geometric configuration but also with fatty acid chain length and double bond position. This mechanism could explain, in part, the conflicting results seen among studies investigating the effects of total dietary trans fatty acids on serum lipid and lipoprotein concentrations.
Matthan
N R
NR
School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Québec, Canada.
Jones
P J
PJ
D005227:Fatty Acids / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000187:drug effects* / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D008074:Lipoproteins