title: Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To assess the association between polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) and systemic erythematosus (SLE) in Japanese people.
  
  
  METHODS
  We examined the IL-10 receptor genotype of 109 SLE patients and 102 healthy subjects by the reverse transcription-polymerase chain reaction-restriction fragment length polymorphism (RT-PCR-RFLP) method.
  
  
  RESULTS
  There was no difference in the IL10R genotype frequencies of these two groups.
  
  
  CONCLUSIONS
  The IL10R genotype does not determine susceptibility to SLE in Japanese people.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: M
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Yamaoka
authors.forename: E
authors.initials: E
authors.lastname: Ogami
authors.forename: S
authors.initials: S
authors.lastname: Nagano
authors.forename: Y
authors.initials: Y
authors.lastname: Arinobu
authors.forename: H
authors.initials: H
authors.lastname: Niiro
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018076:DNA, Complementary / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018123:Receptors, Interleukin / Q000235:genetics*; D053701:Receptors, Interleukin-10; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018076:DNA, Complementary; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10