title: Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31.
abstract: Essential myoclonus-dystonia is a neurological condition characterized by myoclonic and dystonic muscle contractions and the absence of other neurological signs or laboratory abnormalities; it is often responsive to alcohol. The disorder may be familial with apparent autosomal dominant inheritance. We report a large kindred with essential familial myoclonus-dystonia and map a locus for the disorder to a 28-cM region of chromosome 7q21-q31.
authors.affiliation: Department of Neurology, East Orange Veteran's Administration Medical Center, NJ, USA.
authors.forename: T G
authors.initials: TG
authors.lastname: Nygaard
authors.forename: D
authors.initials: D
authors.lastname: Raymond
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: I
authors.initials: I
authors.lastname: Nishino
authors.forename: P E
authors.initials: PE
authors.lastname: Greene
authors.forename: D
authors.initials: D
authors.lastname: Jennings
authors.forename: G A
authors.initials: GA
authors.lastname: Heiman
authors.forename: C
authors.initials: C
authors.lastname: Klein
authors.forename: R J
authors.initials: RJ
authors.lastname: Saunders-Pullman
authors.forename: P
authors.initials: P
authors.lastname: Kramer
authors.forename: L J
authors.initials: LJ
authors.lastname: Ozelius
authors.forename: S B
authors.initials: SB
authors.lastname: Bressman
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002460:Cell Line; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002886:Chromosomes, Human, Pair 17; D004247:DNA / Q000097:blood; D004421:Dystonia / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000235:genetics*; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D004247:DNA