Modern antioestrogens and the coming revolution in women's health care.
This review will focus on antioestrogens and selective oestrogen receptor modulators (SERMS). The more traditional SERMS, clomiphene citrate and tamoxifen, will be reviewed along with such modern drugs as raloxifene and faslodex, with emphasis upon their actions on breast, uterus, bone and lipids. The future potential of these medications, in the management of oestrogen-dependent gynaecological conditions such as endometriosis, dysfunctional uterine bleeding, fibroids and breast cancer will be discussed.
Evans
A
A
Monash University Department of Obstetrics and Gynaecology, Monash Medical Centre, Victoria.
Vollenhoven
B
B
Healy
D
D
D001842:Bone and Bones / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D002996:Clomiphene / Q000494:pharmacology / Q000627:therapeutic use; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D020847:Estrogen Receptor Modulators / Q000494:pharmacology / Q000627:therapeutic use; D004968:Estrogens, Non-Steroidal; D005260:Female; D000077267:Fulvestrant; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D007529:Isoflavones; D010024:Osteoporosis / Q000188:drug therapy; D048789:Phytoestrogens; D028321:Plant Preparations; D010944:Plants; D020849:Raloxifene Hydrochloride / Q000494:pharmacology / Q000627:therapeutic use; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology / Q000627:therapeutic use; D013629:Tamoxifen / Q000494:pharmacology / Q000627:therapeutic use; D016387:Women's Health
D020847:Estrogen Receptor Modulators; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D002996:Clomiphene; D000077267:Fulvestrant; D020849:Raloxifene Hydrochloride; D004958:Estradiol