title: Chemotherapy of medulloblastoma.
abstract: Recent advances in neurosurgical techniques and diagnostic imaging capabilities have facilitated gross total resection and accurate staging of disease extent in a greater proportion of patients. The addition of chemotherapy to surgery and craniospinal radiation has improved the outcome of patients diagnosed with medulloblastoma. Long-term follow-up studies have documented the neuroendocrine and neuropsychological deficits seen in the survivors. This paper reviews key studies using all three modalities over the past two decades and presents on-going therapeutic strategies using a risk-adapted approach. Further areas of basic research and evolving data on studies in relapsed patients are also briefly discussed.
authors.affiliation: St. Jude Children's Research Hospital, 332 N. Lauderdale St., Memphis, TN 38105-2729, USA. amar.gaijar@stjude.org
authors.forename: A
authors.initials: A
authors.lastname: Gajjar
authors.forename: J
authors.initials: J
authors.lastname: Kühl
authors.forename: S
authors.initials: S
authors.lastname: Epelman
authors.forename: C
authors.initials: C
authors.lastname: Bailey
authors.forename: J
authors.initials: J
authors.lastname: Allen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002675:Child, Preschool; D006801:Humans; D008527:Medulloblastoma / Q000188:drug therapy*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents