title: Nonpeptidic SH2 inhibitors of the tyrosine kinase ZAP-70.
abstract: The synthesis of a series of 1,2,4-oxadiazole analogs is discussed along with their ZAP-70 SH2 inhibitory activity. The tyrosine moiety in the original series has been replaced with nonpeptidic functional groups without a substantial loss of binding affinity.
authors.affiliation: ARIAD Pharmaceuticals, Inc., Cambridge MA 02139-4234, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Vu
authors.forename: E G
authors.initials: EG
authors.lastname: Corpuz
authors.forename: S G
authors.initials: SG
authors.lastname: Pradeepan
authors.forename: S
authors.initials: S
authors.lastname: Violette
authors.forename: C
authors.initials: C
authors.lastname: Bartlett
authors.forename: T K
authors.initials: TK
authors.lastname: Sawyer
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005454:Fluorescence Polarization; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D051746:ZAP-70 Protein-Tyrosine Kinase; D018909:src Homology Domains
chemical_list: D004791:Enzyme Inhibitors; D011505:Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase