Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine.
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
Frey
S
S
Saint Louis University Health Sciences Center, St. Louis, MO 63110, USA.
Dagan
R
R
Ashur
Y
Y
Chen
X Q
XQ
Ibarra
J
J
Kollaritsch
H
H
Mazur
M H
MH
Poland
G A
GA
Reisinger
K
K
Walter
E
E
Van Damme
P
P
Braconier
J H
JH
Uhnoo
I
I
Wahl
M
M
Blatter
M M
MM
Clements
D
D
Greenberg
D
D
Jacobson
R M
RM
Norrby
S R
SR
Rowe
M
M
Shouval
D
D
Simmons
S S
SS
van Hattum
J
J
Wennerholm
S
S
Gress
J O
JO
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D022362:Hepatitis A Vaccines; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D008297:Male; D014611:Vaccination; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology*; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage / Q000276:immunology*
D022362:Hepatitis A Vaccines; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined; D014761:Viral Hepatitis Vaccines