title: Monoamine oxidase inhibitory naphthoquinone and/or naphthalene dimers from Lemuni Hitam (Diospyros sp.), a Malaysian herbal medicine.
abstract: From the extract of a Malaysian herbal medicine, Lemuni Hitam (Diospyros sp.), which exhibited monoamine oxidase (MAO) inhibition, three new naphthoquinone and/or naphthalene dimers (lemuninols A-C, 1-3) were isolated together with 4,6-dihydroxy-5-methoxy-2-methyl-naphthalene (8) and six known monomers (4-7, 9 and 10). The structures were determined by spectroscopic methods including 2D-NMR techniques. Among them, lemuninol A showed 45% inhibition of MAO (mouse liver) at 5.0 x 10(-6) g/ml, and lemuninols B and C and a naphthoquinone (9) indicated weak activity. Some related quinones were also tested for their MAO inhibitory activities.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Okuyama
authors.forename: M
authors.initials: M
authors.lastname: Homma
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Fujimoto
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Satake
authors.forename: A B
authors.initials: AB
authors.lastname: Ghazali
mesh_terms: D000818:Animals; D019281:Dimerization; D008297:Male; D051379:Mice; D008956:Models, Chemical; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008996:Monoamine Oxidase Inhibitors; D009281:Naphthalenes; D009285:Naphthoquinones; D010936:Plant Extracts; C031721:naphthalene