Basic principles for compounding all-in-one parenteral nutrition admixtures.
Parenteral nutrition admixtures are complex pharmaceutical entities. The more closely they are examined, the more physico-chemical interactions emerge that could potentially affect stability. The move towards large scale hospital or commercial preparation, with a requirement for extended shelf life, and the increasing use of admixtures as vehicles for drugs and pharmaconutrients have created new formulation challenges for pharmaceutical scientists.
Hardy
G
G
School of Pharmacy, University of Otago, Dunedin, New Zealand. nutrinox@aol.com
Ball
P
P
McElroy
B
B
D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002627:Chemistry, Physical; D004333:Drug Administration Routes; D004655:Emulsions; D006801:Humans; D010288:Parenteral Nutrition
D004655:Emulsions