title: Systemic sclerosis and scleroderma renal crisis in association with carcinoma of the breast.
abstract: During recent years it has been shown conclusively that the incidence of malignancy in systemic sclerosis (SSc) is significantly increased and that rapidly progressive skin thickening, among other factors, is a strong predictor of scleroderma renal crisis (SRC). We present a case of carcinoma of the breast presenting concurrently with SSc that subsequently progressed to dialysis-dependent renal failure in just 1 month. We discuss the possible relationship between SSc and malignancy at a cellular level. In conclusion, we recommend that patients with rapidly progressive SSc and SRC at an early stage be screened for malignancy. In those patients developing malignancy in SSc, a careful vigil for accelerated renal, cardiac, and pulmonary complications should also be undertaken.
authors.affiliation: Department of General Medicine, Bradford Hospitals NHS Trust, Bradford, West Yorks, UK.
authors.forename: R
authors.initials: R
authors.lastname: Booton
authors.forename: R
authors.initials: R
authors.lastname: Jeffrey
authors.forename: P N
authors.initials: PN
authors.lastname: Prabhu
mesh_terms: D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D012077:Renal Artery / Q000473:pathology; D051437:Renal Insufficiency / Q000175:diagnosis* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000473:pathology