[Selection of antigenic variants of influenza virus hemagglutinin by host cells and choice of the optimal system for culturing them].
Reviews published reports on the relationship between the culturing system and formation of antigenic variants of influenza virus. Analyzes molecular biological changes in the virus hemagglutinin and the main methods of selection. Discusses the significance of this phenomenon for sero-epidemiological studies, influenza surveillance, and production of anti-influenza vaccines and diagnostic agents.
Govorkova
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EA
D000818:Animals; D018929:Cell Culture Techniques; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000276:immunology*; D007252:Influenza Vaccines; D009975:Orthomyxoviridae / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000175:diagnosis / Q000517:prevention & control
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines