title: MRI in neuro-Behçet's syndrome: comparison of conventional spin-echo and FLAIR pulse sequences.
abstract: We compared the sensitivity of a fluid-attenuated inversion-recovery (FLAIR) sequence with that of a conventional dual-echo spin-echo (SE) sequence) to brain lesions in 20 patients with Behçet's syndrome. They underwent 25 MRI examinations. The images were independently analysed for the number, type and anatomical location of lesions shown. There were 18 abnormal studies (13 initial and 5 follow-up). The FLAIR sequence detected significantly more lesions than the SE TE 80 (P < 0.05) and SE TE 20 (P < 0.01) sequences. It was particularly useful for demonstrating lesions in the juxtacortical white matter, which accounted for over half the lesions detected on the FLAIR images. Of patients presenting with nonspecific symptoms such as headache, seven had normal and five had abnormal studies. All patients presenting with focal neurological signs had abnormal imaging. We found supratentorial and, in particular, juxtacortical lesions to be more frequent than previously described.
authors.affiliation: Department of Imaging, Hammersmith Hospital, DuCane Road, London W12 0HS, UK. r.jager@ion.ucl.ac.uk
authors.forename: H R
authors.initials: HR
authors.lastname: Jäger
authors.forename: T
authors.initials: T
authors.lastname: Albrecht
authors.forename: W L
authors.initials: WL
authors.lastname: Curati-Alasonatti
authors.forename: E J
authors.initials: EJ
authors.lastname: Williams
authors.forename: D O
authors.initials: DO
authors.lastname: Haskard
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity