title: Enantioselective separation of 1,4-disubstituted piperazine derivatives on two cellulose chiralcel OD and OJ and one amylose chiralpak AD chiral selectors
abstract: A series of 1,4-disubstituted piperazine derivatives with hypnotic activity were examined on three polysaccharide-based chiral stationary phases, namely, Chiracel OD, Chiracel OJ and Chiralpak AD. It was possible to resolve all the compounds on all the phases examined (1.13 </= alpha </= 3.54). Cellulose tris(4-methylbenzoate) (Chiracel OJ) exhibited remarkable differences in the selectivity of enantiomeric resolution as compared to cellulose tris(3, 5-dimethylphenylcarbamate)-Chiracel OD and amylose tris(3, 5-dimethylphenylcarbamate)-Chiralpak AD. The differences in selectivity towards particular homologs on these phases could be explained in terms of lipophilicity and steric factors. Copyright 1999 Wiley-Liss, Inc.
authors.affiliation: Pharmaceutical Research Institute, Department of Chemistry, Warsaw, Poland.
authors.initials: Z
authors.lastname: Chilmonczyk
authors.initials: H
authors.lastname: Ksycinska
authors.initials: M
authors.lastname: Mazgajska
authors.initials: HY
authors.lastname: Aboul-Enein