Specific RNA Dinucleotide Cleavage by a Synthetic Calix
Large rate enhancements and considerable nucleobase specificity in the catalytic transesterification of RNA dinucleotides are observed with the calix[4]arene enzyme mimic 1-Zn(3) (the computer-generated model of the complex with GpG is shown). The higher activity toward GpG over ApA (factor of 160) originates from favorable substrate binding and cooperative catalytic action of all three Zn(II) ions. The heterotrinuclear metallo-phosphoesterase mimic 1-Zn(2)Cu is even more active.
Molenveld
P
Laboratory of Supramolecular Chemistry and Technology, MESA(+) Research Institute, University of Twente, P.O. Box 217, NL-7500 AE Enschede (The Netherlands).
Engbersen
JF
Reinhoudt
DN