title: Radiographic, biomechanical, and pathologic effects of hemoglobin glutamer-200 in dogs undergoing cemented total hip arthroplasty.
abstract: OBJECTIVE
  To determine whether use of hemoglobin glutamer-200 (bovine) as a partial blood volume replacement in dogs undergoing cemented total hip replacement caused any deleterious effects on the bone-cement or cement-prosthesis interface, exerted any deleterious effects on body organs, or caused any complications during the anesthetic, immediate recovery, or long-term recovery period.
  
  
  METHODS
  9 adult dogs.
  
  
  METHODS
  Dogs were anesthetized, and 15% of the blood volume was removed. Simultaneously, lactated Ringer's solution was infused, and 6 dogs were given hemoglobin glutamer (1 g/kg of body weight, IV). Unilateral total hip replacement was performed. Limb use was assessed visually, and force-plate and radiographic evaluations were performed before, and 8 weeks after, surgery. Eight weeks after surgery, dogs were euthanatized, necropsies were performed, and prosthetic component pullout forces were determined.
  
  
  RESULTS
  There were no significant differences between treated and control dogs in regard to biomechanical (visual assessment of gait, force-plate analysis, femoral and acetabular component pullout forces) and pathologic evaluations (physical examination, CBC, serum biochemical analyses, necropsy, and histologic evaluations). Radiographic signs of loosening of the femoral component were seen in 4 dogs treated with hemoglobin glutamer.
  
  
  CONCLUSIONS
  Administration of hemoglobin glutamer as a blood substitute did not appear to have any deleterious effects in dogs undergoing total hip arthroplasty. The radiographic findings, which were discordant with the biomechanical results, merit further investigation.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Braden
authors.forename: H W
authors.initials: HW
authors.lastname: Tvedten
authors.forename: C E
authors.initials: CE
authors.lastname: DeCamp
authors.forename: T M
authors.initials: TM
authors.lastname: Turner
authors.forename: G S
authors.initials: GS
authors.lastname: Hughes
authors.forename: V T
authors.initials: VT
authors.lastname: Rentko
mesh_terms: D000077:Acetabulum / Q000187:drug effects; D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000379:methods / Q000662:veterinary*; D001696:Biomechanical Phenomena; D001774:Blood Chemical Analysis; D001802:Blood Substitutes / Q000494:pharmacology*; D001843:Bone Cements; D002417:Cattle; D004285:Dogs; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000187:drug effects; D005684:Gait; D006454:Hemoglobins; D008297:Male; D011859:Radiography
chemical_list: D001802:Blood Substitutes; D001843:Bone Cements; D006454:Hemoglobins; C402601:hemoglobin glutamer-200