title: [Contact urticaria, rhinoconjunctivitis and bronchial asthma from occupational use of papain].
abstract: Papain is a plant protein with a wide pharmacological, domestic and industrial use. It leads a high sensitisation, being the most common rotue of entry the inhalation. The occupational allergy to papain in exposed workers was described some years ago, being presented with bronchial asthma, rhinitis or both. In most of the cases, the specific IgE was positive. We present a case contact urticaria, rhinoconjunctivitis and bronchial asthma per papain of occupational origin. Papain prick test, specific IgE and nasal challenge were positive. The peak flow record showed diary decreases during the working week and the basal spirometry showed obstruction to the airflow. The patient was moved away the place where papain was handled and this resolved the clinical symptoms and the spirometry returns to the normal values. We present a case of IgE-mediated allergy, vehicled by tow routes: contact and airborne. The latest produced clinical manifestations later. Papain was used as Cephalopoda softening, because of that it worth emphasising its seasonal use.
authors.affiliation: Sección de Alergología, Hospital Universitario "Marqués de Valdecilla", Santander, Cantabria, España.
authors.forename: D
authors.initials: D
authors.lastname: Quiñones
authors.forename: S
authors.initials: S
authors.lastname: Alonso
authors.forename: R
authors.initials: R
authors.lastname: López
authors.forename: I
authors.initials: I
authors.lastname: Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez
authors.forename: L
authors.initials: L
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Jerez
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D003231:Conjunctivitis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced*; D010206:Papain / Q000009:adverse effects*; D012220:Rhinitis / Q000139:chemically induced*; D012882:Skin Tests; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D010206:Papain