Linkage mapping of a new syndromic form of X-linked mental retardation, MRXS7, associated with obesity.
A new syndromic form of X-linked mental retardation associated to obesity, MRXS7, has been localised to Xp11.3-Xq23 in a large Pakistani family. The ten affected males show clinical manifestations of mental retardation, obesity and hypogonadism. The family was genotyped by a set of microsatellite markers spaced at approximately 10 cM intervals on the X chromosome. Linkage to five adjacent microsatellite markers, mapping in the pericentromeric area, was established and a maximum two-point lod score of 3.86 was reached at zero recombination with marker DXS1106. Reduced recombination events around the centromere prevented precise mapping of the gene.
Ahmad
W
W
Telethon Institute of Genetics and Medicine, Milan, Italy.
De Fusco
M
M
Faiyaz ul Haque
M
M
Aridon
P
P
Sarno
T
T
Sohail
M
M
ul Haque
S
S
Ahmad
M
M
Ballabio
A
A
Franco
B
B
Casari
G
G
D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D010375:Pedigree; D013577:Syndrome; D014960:X Chromosome / Q000235:genetics*