title: Pulsatile ocular blood flow in diabetic retinopathy.
abstract: OBJECTIVE
  To assess circulatory properties of eyes with progressive stages of diabetic retinopathy.
  
  
  METHODS
  The intraocular pressure, pulse amplitude (PA) and pulsatile ocular blood flow (POBF) were measured with a pneumatonometer (OBF Labs UK Ltd). The eyes were grouped: (a) normal control, n = 26, (b) diabetes with no observable diabetic retinopathy (NDR), n = 18, (c) mild to moderate non-proliferative diabetic retinopathy (NPDR), n = 20, and (d) very severe pre-proliferative and proliferative diabetic retinopathy (PPDR/PDR), n = 12.
  
  
  RESULTS
  The PA and POBF values were lower than normal values in the earliest stage (NDR). The POBF increased but was still below normal levels at the NPDR stage, and then increased to an above normal level in the PPDR/PDR stage of diabetic retinopathy. The PA was at normal levels in these later two stages.
  
  
  CONCLUSIONS
  An initial decrease in pulsatile ocular blood flow is present with the onset of diabetes where no diabetic retinopathy has yet occurred. Subsequently, the pulsatile ocular blood flow increases with the severity of the retinopathy.
authors.affiliation: Department of Ophthalmology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Geyer
authors.forename: M
authors.initials: M
authors.lastname: Neudorfer
authors.forename: T
authors.initials: T
authors.lastname: Snir
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: T
authors.initials: T
authors.lastname: Rock
authors.forename: D M
authors.initials: DM
authors.lastname: Silver
authors.forename: E
authors.initials: E
authors.lastname: Bartov
mesh_terms: D000368:Aged; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D018450:Disease Progression; D005123:Eye / Q000098:blood supply*; D006801:Humans; D008875:Middle Aged; D011673:Pulsatile Flow; D012016:Reference Values; D012039:Regional Blood Flow; D012720:Severity of Illness Index