title: Responsiveness of the Scripps neurologic rating scale during a multiple sclerosis clinical trial.
abstract: OBJECTIVE
  The Scripps neurologic rating scale (SNRS) is a summary measure of individual components comprising a neurological examination, designed for use in multiple sclerosis (MS). Our objective is to evaluate the responsiveness of the SNRS, within the context of a 2-year, randomized, double-blind crossover study of the efficacy of cladribine for treatment of secondary progressive MS.
  
  
  METHODS
  Effect sizes were determined for the SNRS and its components, separately for each treatment group (initial placebo, and initial cladribine) over both years of the clinical trial, using a standard random effects model.
  
  
  RESULTS
  Individual components tended to show positive effect sizes (improvement) during periods of active therapy in both treatment groups, and negative effect sizes (deterioration) during periods of no active therapy. Summation indices derived from the individual components of the SNRS seemed somewhat more stable than the individual components. The two components mentation and mood, and bladder, bowel, or sexual dysfunction, were rather unresponsive in our clinical trial.
  
  
  CONCLUSIONS
  Changes in the components of the SNRS over the course of our clinical trial were consistent between the two treatment groups. Most components were moderately responsive; and, the summary SNRS score appropriately summarized the moderate magnitudes of change evinced in the individual components.
authors.affiliation: Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 90237, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Koziol
authors.forename: A
authors.initials: A
authors.lastname: Lucero
authors.forename: J C
authors.initials: JC
authors.lastname: Sipe
authors.forename: J S
authors.initials: JS
authors.lastname: Romine
authors.forename: E
authors.initials: E
authors.lastname: Beutler
mesh_terms: D017338:Cladribine / Q000008:administration & dosage; D018592:Cross-Over Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000523:psychology; D009460:Neurologic Examination / Q000379:methods* / Q000592:standards*; D009483:Neuropsychological Tests / Q000592:standards; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D017338:Cladribine