Thy-1 is critical for normal retinal development.
In the mammalian retina, Thy-1, the most abundant mammalian neuronal surface glycoprotein, is found predominantly if not exclusively on retinal ganglion cells. We hypothesized that Thy-1 plays a significant role in retinal development. Neurite outgrowth of retinal ganglion cells from Thy-1(-) mice over multiple substrates was compared to that seen with wild-type controls. Adult mouse retinas were histologically compared between Thy-1(-) and three strains of Thy-1 positive mice. Thy-1(-) retinal ganglion cells had significantly less neurite outgrowth than controls. The inner nuclear, inner plexiform, ganglion cell and outer segment/pigment epithelium layers were thinner in Thy-1(-) retinae than in controls. Thy-1 appears to be critical for normal retinal development.
Simon
P D
PD
The Department of Ophthalmology, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA, USA.
McConnell
J
J
Zurakowski
D
D
Vorwerk
C K
CK
Naskar
R
R
Grosskreutz
C L
CL
Dreyer
E B
EB
D000818:Animals; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout / Q000235:genetics; D016501:Neurites / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000254:growth & development*; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D018800:Thy-1 Antigens / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D018800:Thy-1 Antigens