The expression of transforming growth factor beta (TGF-beta) in the synovial membrane of human temporomandibular joint with internal derangement: a comparison with tenascin expression.
We examined the expression of the transforming growth factor beta (TGF-beta) in 28 human temporomandibular joint (TMJ) samples (internal derangement of TMJ and control specimens) by an immunohistological method using paraffin-embedded tissues and a polyclonal antibody specific to human TGF-beta. The resulting reaction of TGF-beta expression divided into three types as follows. The first type, around the fibrocyte and in the lacunae of chondrocytes in the disc. The second type, at the stroma of the mildly hypertrophic synovial membrane and severely hypertrophic synovial membrane. The first type was observed in all the cases including the control cases. The second type showed only in the internal derangement of TMJ, and its expression pattern resembled that of tenascin (TN) within the stroma of hypertrophic synovial membranes. In conclusion, TGF-beta and TN were distributed in the affected synovial membrane of TMJ with internal derangement. These findings suggested that TGF-beta and TN might have a close relationship with synovitis, followed by tissue repair.
Yoshida
H
H
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
Yoshida
T
T
Iizuka
T
T
Sakakura
T
T
Fujita
S
S
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology; D013704:Temporomandibular Joint / Q000378:metabolism* / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*; D019063:Tenascin / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D019063:Tenascin; D016212:Transforming Growth Factor beta