Inhibitory effect of nitric oxide on the renin-angiotensin system in Dahl salt-sensitive rats.
1. To explore the role of nitric oxide (NO) in the regulation of the renin-angiotensin system (RAS) in Dahl salt-sensitive (DS) rats, the effects of NG-nitro-L-arginine methyl ester (L-NAME) on plasma renin activity (PRA), and concentrations of angiotensin (Ang)I and AngII in the plasma, aorta and kidney were investigated in DS and Dahl salt-resistant (DR) rats. 2. NG-Nitro-L-arginine methyl ester (12-18 mg/kg per day) administration for 1 week increased mean arterial pressure (MAP) in DS and DR rats fed a 0.3% NaCl diet and in DR rats fed an 8% NaCl diet compared with corresponding vehicle (water)-treated groups. However, L-NAME administration did not change MAP in DS rats fed an 8% NaCl diet. 3. NG-Nitro-L-arginine methyl ester administration increased PRA in DS rats fed an 8% NaCl diet, but not in DR rats fed an 8% NaCl diet. NG-Nitro-L-arginine methyl ester administration increased AngI and AngII concentrations in plasma, aorta and kidney only in DS rats fed an 8% NaCl diet. The ratio of AngI to AngII did not change following L-NAME administration in any rats. 4. These results suggest that NO has an inhibitory role on renin release in DS rats fed a high-salt diet.
Kasuya
A
A
Department of Pharmacology, Tohoku University, Sendai, Japan.
Satoh
S
S
Yoshida
M
M
Hisa
H
H
Suzuki-Kusaba
M
M
Satoh
S
S
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D009569:Nitric Oxide / Q000502:physiology* / Q000652:urine; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D051381:Rats; D020303:Rats, Inbred Dahl; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology; D013045:Species Specificity
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D012965:Sodium Chloride; D007703:Peptidyl-Dipeptidase A; D012083:Renin; D019331:NG-Nitroarginine Methyl Ester