title: The appearance of L-selectin(low) polymorphonuclear leukocytes in the circulating pool of peripheral blood during myocardial infarction correlates with neutrophilia and with the size of the infarct.
abstract: BACKGROUND
  It is assumed that not only leukocytosis, but also the activation of white blood cells (WBC) may play a role in the pathogenesis and prognosis of patients with myocardial infarction (MI). Activation of WBC includes upregulation of CD11b/CD18 and downregulation of CD62L (L-selectin) antigens.
  
  
  OBJECTIVE
  The activation of WBC is associated with the appearance of a larger MI.
  
  
  METHODS
  CD11b/CD18 and CD62L were measured on the surface of WBC on Day 1 and Day 3 from the onset of MI. The size of the infarct with estimated by calculating the area under the curve of the creatine kinase enzyme, which was measured every 6 h.
  
  
  RESULTS
  A negative correlation was noted between the absolute polymorphonuclear count and the availability of the CD62L on these cells during Day 1 (r = -0.46, p = 0.003) and Day 3 (r = -0.35, p = 0.05). There was a positive correlation between the size of MI and the WBC count (r = 0.46, p = 0.004) and a negative correlation with CD62L on polymorphonuclears (r = -0.35, p = 0.03). During Day 3, the CD11b/CD18 on the polymorphonuclears increased despite a decrement in the absolute number of these cells.
  
  
  CONCLUSIONS
  The neutrophilia during the early phases of acute MI correspond to the appearance of the L-selectin(low) population of polymorphonuclear leukocytes. There is a correlation between the appearance of this population and the size of the infarct.
authors.affiliation: Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Kassirer
authors.forename: D
authors.initials: D
authors.lastname: Zeltser
authors.forename: B
authors.initials: B
authors.lastname: Gluzman
authors.forename: E
authors.initials: E
authors.lastname: Leibovitz
authors.forename: Y
authors.initials: Y
authors.lastname: Goldberg
authors.forename: A
authors.initials: A
authors.lastname: Roth
authors.forename: G
authors.initials: G
authors.lastname: Keren
authors.forename: R
authors.initials: R
authors.lastname: Rotstein
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: N
authors.initials: N
authors.lastname: Arber
authors.forename: A S
authors.initials: AS
authors.lastname: Berliner
mesh_terms: D000368:Aged; D000943:Antigens, Differentiation / Q000502:physiology*; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D037502:Galectin 3; D006801:Humans; D019041:L-Selectin / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology; D009504:Neutrophils; D015854:Up-Regulation / Q000502:physiology
chemical_list: D000943:Antigens, Differentiation; D037502:Galectin 3; D019041:L-Selectin