Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism.
Cationic ammonium fullerene derivatives (C60-bis(N, N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
Mashino
T
T
Kyoritsu College of Pharmacy, Tokyo, Japan.
Okuda
K
K
Hirota
T
T
Hirobe
M
M
Nagano
T
T
Mochizuki
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002244:Carbon; D010100:Oxygen