title: Conformationally restricted paclitaxel analogues: macrocyclic mimics of the "hydrophobic collapse" conformation.
abstract: Conformationally restricted macrocyclic analogues of paclitaxel were prepared, by connecting the 3'-phenyl group and the 2-benzoate moiety with two-atom tethers to mimic the "hydrophobic collapse" paclitaxel conformation. The analogues did not show activity in a tubulin assembly assay.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Boge
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wu
authors.forename: R H
authors.initials: RH
authors.lastname: Himes
authors.forename: D G
authors.initials: DG
authors.lastname: Vander Velde
authors.forename: G I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel