title: Successful outcome of pregnancy in a thyroidectomized-parathyroidectomized young woman affected by severe hypothyroidism.
abstract: Severe hypothyroidism was discovered in a young woman in her 29th week of pregnancy. Previously, at the age of 12 years, she had undergone thyroid surgery for Graves' disease that resulted in persistent hypothyroidism and hypoparathyroidism. After surgical excision, the patient started levothyroxine replacement therapy and had regular control of thyroid function with normal findings throughout the years. The dose of levothyroxine had not been adjusted when the pregnancy started, and at the 29th week of gestation the patient had a thyrotropin (TSH) of 72.4 microU/mL. Ultrasound studies were performed in order to monitor fetal development. The fetal parameters analyzed before the adjustment of levothyroxine therapy showed growth retardation of various degrees. All analyzed fetal parameters (biparietal diameter, cranial and abdominal circumference, humerus and femur length) improved during the last 6 weeks of gestation, showing a good correlation with the newly achieved euthyroid state of the mother. The infant was clinically euthyroid at birth and was found normal at all evaluations of the neonatal hypothyroidism screening program (1, 5, 30 days).
authors.affiliation: Institute of Endocrinology, II University of Naples, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rotondi
authors.forename: C
authors.initials: C
authors.lastname: Caccavale
authors.forename: C
authors.initials: C
authors.lastname: Di Serio
authors.forename: A
authors.initials: A
authors.lastname: Del Buono
authors.forename: F
authors.initials: F
authors.lastname: Sorvillo
authors.forename: D
authors.initials: D
authors.lastname: Glinoer
authors.forename: A
authors.initials: A
authors.lastname: Bellastella
authors.forename: C
authors.initials: C
authors.lastname: Carella
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D006111:Graves Disease / Q000601:surgery; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy; D007231:Infant, Newborn; D016105:Parathyroidectomy; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood; D016216:Ultrasonography, Prenatal
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine