title: Viral infections in interferon-gamma receptor deficiency.
abstract: Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.
authors.affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Department of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Dorman
authors.forename: G
authors.initials: G
authors.lastname: Uzel
authors.forename: J
authors.initials: J
authors.lastname: Roesler
authors.forename: J S
authors.initials: JS
authors.lastname: Bradley
authors.forename: J
authors.initials: J
authors.lastname: Bastian
authors.forename: G
authors.initials: G
authors.lastname: Billman
authors.forename: S
authors.initials: S
authors.lastname: King
authors.forename: A
authors.initials: A
authors.lastname: Filie
authors.forename: J
authors.initials: J
authors.lastname: Schermerhorn
authors.forename: S M
authors.initials: SM
authors.lastname: Holland
mesh_terms: D015703:Antigens, CD / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology; D007223:Infant; D008297:Male; D009164:Mycobacterium Infections / Q000276:immunology*; D010641:Phenotype; D017471:Receptors, Interferon / Q000172:deficiency* / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D000096743:Interferon gamma Receptor
chemical_list: D015703:Antigens, CD; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor