Isolation of xestosterol esters of brominated acetylenic fatty acids from the marine sponge xestospongia testudinaria
The CH(2)Cl(2) extract of the marine sponge Xestospongia testudinaria inhibited [(3)H]DPCPX binding to rat-brain adenosine A(1) receptors. Bioassay-guided fractionation led to the isolation of a known brominated acetylenic fatty acid 1 as the active component. Also isolated were two novel sterol esters 2 and 3. All structures were determined on the basis of their spectroscopic data.
Pham
NB
Queensland Pharmaceutical Research Institute, Griffith University, Brisbane, Australia 4111, and Queensland Museum, P.O. Box 3300, Brisbane, Australia 4101.
Butler
MS
Hooper
JN
Moni
RW
Quinn
RJ