Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.
One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.
Schneider
J
J
Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK. joerg@oxxon.freeserve.co.uk
Gilbert
S C
SC
Hannan
C M
CM
Dégano
P
P
Prieur
E
E
Sheu
E G
EG
Plebanski
M
M
Hill
A V
AV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000008:administration & dosage; D005822:Genetic Vectors; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D008288:Malaria / Q000276:immunology / Q000517:prevention & control; D017780:Malaria Vaccines / Q000008:administration & dosage; D051379:Mice; D011323:Primates; D019444:Vaccines, DNA / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000939:Epitopes; D017780:Malaria Vaccines; D019444:Vaccines, DNA