title: Stabilization of microtubules by Combretastatin D derivatives.
abstract: The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active.
authors.affiliation: Chemistry Laboratories, Agricultural University of Athens, Greece. ecoula@mail.ariadne-t.gr
authors.forename: E A
authors.initials: EA
authors.lastname: Couladouros
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: V I
authors.initials: VI
authors.lastname: Moutsos
authors.forename: E N
authors.initials: EN
authors.lastname: Pitsinos
authors.forename: I C
authors.initials: IC
authors.lastname: Soufli
mesh_terms: D001632:Bibenzyls / Q000737:chemistry / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*; D015394:Molecular Structure; D013267:Stilbenes
chemical_list: D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin