Obstructive nephropathy due to sulfa crystals in two HIV seropositive patients treated with sulfadiazine.
Two HIV seropositive patients receiving sulfadiazine for presumed cerebral toxoplasmosis who developed an obstructive nephropathy are described. Ultrasound examination showed respectively a bilateral hydro-ureteronephrosis in one patient and unilateral hydro-ureteronephrosis in the other. The obstructive nephropathy resolved in both patients with alkalic hydration and discontinuation of the sulfadiazine.
Colebunders
R
R
Institute of Tropical Medicine, Department of Clinical Sciences, Antwerp, Belgium.
Depraetere
K
K
De Droogh
E
E
Kamper
A
A
Corthout
B
B
Bottiau
E
E
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000468:Alkalies / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000009:adverse effects*; D003460:Crystallization; D005260:Female; D005440:Fluid Therapy; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D006869:Hydronephrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007669:Kidney Calculi / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D013411:Sulfadiazine / Q000009:adverse effects*; D016781:Toxoplasmosis, Cerebral / Q000188:drug therapy; D014463:Ultrasonography; D014515:Ureteral Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging
D000468:Alkalies; D000981:Antiprotozoal Agents; D013411:Sulfadiazine