Evaluation of a multivariate prostate-specific antigen and percentage of free prostate-specific antigen logistic regression model in the diagnosis of prostate cancer.
The use of prostate-specific antigen (PSA) in the diagnosis of prostate cancer is controversial due to false-positive results caused by benign prostatic hyperplasia. Several groups have suggested the usefulness of the percentage of free PSA (%fPSA) in patients with PSA levels between 4 and 10 microg/l. Based on previously obtained results, biopsy is carried out in our hospital if the PSA is greater than 10 microg/l or if the %fPSA is lower than 20% and PSA is between 4-10 microg/l. In this study, we have compared these results with those obtained with a logistic regression model based on the determination of PSA and %fPSA. The diagnostic efficacy of the logistic regression model is greater than that of the currently used model. The posterior construction of a nomogram based on the data obtained greatly facilitates the application of the logistic regression model.
Filella
X
X
Department of Clinical Biochemistry (Unit for Cancer Research), 'Institut d'Investigacions Biomèdiques August Pi i Sunyer', Hospital Clínic, Barcelona, Spain. xfilella@medicina.ub.es
Alcover
J
J
Quintó
L
L
Molina
R
R
Bosch-Capblanch
X
X
Carretero
P
P
Ballesta
A M
AM
D000368:Aged; D006801:Humans; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D015999:Multivariate Analysis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D012044:Regression Analysis; D012189:Retrospective Studies; D016896:Treatment Outcome
D017430:Prostate-Specific Antigen