Cholesterol-dependent regulation of nitric oxide production: potential role in atherosclerosis.
Atherosclerosis is preceded by cholesterol-induced diminution in vascular nitric oxide (NO) production and proatherogenic changes in endothelial cell function. Careful dissection of the steps involved in regulating endothelial nitric oxide synthase (eNOS) activity has revealed that cholesterol-induced caveolin expression reduces NO production by stimulating the production of inhibitory caveolin eNOS complexes.
Coppinger
R J
RJ
Department of Human Nutrition and Dietetics, University of Illinois, Chicago 60612, USA.
Baum
C L
CL
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D051242:Caveolin 1; D022461:Caveolins; D002784:Cholesterol / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000494:pharmacology*; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000378:metabolism*
C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins; D008565:Membrane Proteins; D009569:Nitric Oxide; D002784:Cholesterol; D019001:Nitric Oxide Synthase