Amantadine-induced peripheral neuropathy.
We report a 48-year-old woman with a 17-year history of PD who developed a peripheral sensory-motor neuropathy secondary to chronic administration (8 years) of amantadine. Discontinuation of amantadine resulted in resolution of trophic skin ulcers, paresthesias, and distal weakness. Amantadine may be hazardous to patients with severe and chronic livedo reticularis.
Shulman
L M
LM
Department of Neurology, University of Miami School of Medicine, FL 33136, USA.
Minagar
A
A
Sharma
K
K
Weiner
W J
WJ
D000547:Amantadine / Q000009:adverse effects*; D000978:Antiparkinson Agents / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007866:Leg; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced; D010292:Paresthesia / Q000139:chemically induced; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D017445:Skin Diseases, Vascular / Q000150:complications; D012883:Skin Ulcer / Q000139:chemically induced
D000978:Antiparkinson Agents; D000547:Amantadine