title: Relation between herpes simplex viruses and human immunodeficiency virus infections.
abstract: The rates of herpes simplex virus (HSV) infection are rising, the highest prevalence being in the group infected with the human immunodeficiency virus (HIV). We review the relation between these 2 infections. The presence of genital ulcers increases the transmission of HIV, and the presence of HIV adversely affects the natural history of HSV infection. The detection and treatment of sexually transmitted diseases such as genital herpes actually decrease the rates of HIV infection in groups studied. The treatment of HSV in persons with HIV is challenging because the incidence of immunosuppression increases. Acyclovir resistance is more common in this group, but acyclovir use may prolong survival in some HIV-seropositive patients. Further studies are needed to determine whether persons with HIV disease should routinely be given HSV-specific therapy.
authors.affiliation: Department of Dermatology, University of Texas Medical Branch, Galveston 77555, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Severson
authors.forename: S K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D052776:Female Urogenital Diseases / Q000150:complications; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000150:complications* / Q000517:prevention & control / Q000635:transmission; D006558:Herpes Genitalis / Q000175:diagnosis / Q000188:drug therapy; D006561:Herpes Simplex / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007108:Immune Tolerance; D015994:Incidence; D052801:Male Urogenital Diseases; D015995:Prevalence; D018139:Simplexvirus / Q000502:physiology; D015996:Survival Rate; D014456:Ulcer / Q000150:complications
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir