Inhibin-B as a test of ovarian reserve for infertile women.
The objective of the study was to compare a standard clomiphene citrate challenge test with inhibin-B serum concentrations also obtained on cycle days 3 and 10 as a negative predictor of pregnancy in a group of 106 women at risk for compromised ovarian function. Mean duration of follow-up was 8.25 months in 95 patients with 30 pregnancies recorded (plus one biochemical). Inhibin-B concentrations on cycle days 3 and 10 were correlated only with each other and not with serum oestradiol, follicle stimulating hormone (FSH) and/or pregnancy rates. Pregnancy occurred in 34.5% (10/29) of all patients with inhibin-B values >/=45 pg/ml on cycle day 3 and in 31.8% (21/66) of those with values <45 pg/ml. For FSH >11 mIU/ml on either day, pregnancy rate was 13.6% versus 38.4% for FSH of </=9 mIU/ml (P = 0.03). This study reconfirmed the usefulness of a clomiphene citrate challenge test as an indication of ovarian reserve but failed to find clinical value for inhibin-B testing.
Corson
S L
SL
Women's Institute and Thomas Jefferson University, Department of Obstetrics and Gynecology, Philadelphia, PA, USA.
Gutmann
J
J
Batzer
F R
FR
Wallace
H
H
Klein
N
N
Soules
M R
MR
D000328:Adult; D002996:Clomiphene; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology* / Q000628:therapy; D007265:Inhibins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010053:Ovary / Q000503:physiopathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012099:Reproductive Techniques
D002996:Clomiphene; D004958:Estradiol; D007265:Inhibins; D005640:Follicle Stimulating Hormone