title: Low dose cabergoline induced interstitial pneumonitis.
abstract: Certain dopaminergic anti-Parkinson drugs (ergolines) have repeatedly been identified as a cause of pleuropulmonary disease with a focus on serosal cell damage. Recently, a pathogenetic link between ergolines and prior asbestos exposure was suggested, as regards the development of pleural pathology. This report describes a patient with idiopathic Parkinson's disease, who was on a multiple drug regimen including low dose cabergoline. The patient developed a febrile illness with widespread bilateral lung infiltrations nonresponsive to beta-lactam and macrolide antibiotics. Bronchoalveolar lavage and transbronchial lung biopsy showed a "hypersensitivity-like" interstitial lung disease, which cleared almost completely within 2 months after simple drug withdrawal. Circumstantial evidence suggests a so far undescribed adverse lung reaction to cabergoline, devoid of the more usual pleural changes.
authors.affiliation: Klinik III, Fachklinik für Pneumologie, Johanniterkrankenhaus Im Fläming gGmbH, Treuenbrietzen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Frank
authors.forename: R
authors.initials: R
authors.lastname: Moritz
authors.forename: B
authors.initials: B
authors.lastname: Becke
authors.forename: R
authors.initials: R
authors.lastname: Pauli
mesh_terms: D000368:Aged; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D000077465:Cabergoline; D003937:Diagnosis, Differential; D018491:Dopamine Agonists / Q000009:adverse effects*; D004873:Ergolines / Q000009:adverse effects*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline