title: The genetics of Parkinson's disease.
abstract: Since the first description of Parkinson's disease in 1817 there have been numerous attempts to clarify the relative contribution of hereditary and environmental factors in its aetiology. Epidemiological and case-control studies as well as the existence of families with monogenic Parkinson's disease point clearly to a genetic contribution. Insights into the genetic basis of Parkinson's disease will lead to a greater understanding of the condition at a molecular level which will in turn allow the development of new rational therapeutic option.
authors.affiliation: Department of Clinical Neurology, Institute of Neurology, London, UK.
authors.forename: S D
authors.initials: SD
authors.lastname: Spacey
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
mesh_terms: D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*