title: Cerebral venous sinus thrombosis associated with hepatic cirrhosis.
abstract: Cerebral venous sinus thrombosis is not a recognized complication of end-stage liver disease. A case of sagittal sinus thrombosis in a 44-year-old male with end-stage hepatic cirrhosis is described. Recurrent seizures were the only manifestation. Work-up revealed severe deficiency of protein C, protein S, and antithrombin III. He was treated with low molecular weight heparin and underwent an orthotopic liver transplant after three months. Follow-up helical CT venogram showed resolution of the sinus thrombosis.
authors.affiliation: VBK 802, Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. asinghal@partners.org
authors.forename: A B
authors.initials: AB
authors.lastname: Singhal
authors.forename: F
authors.initials: F
authors.lastname: Buonanno
authors.forename: G
authors.initials: G
authors.lastname: Rordorf
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000188:drug therapy; D002550:Cerebral Veins / Q000000981:diagnostic imaging / Q000473:pathology*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D016031:Liver Transplantation; D008297:Male; D010690:Phlebography; D020225:Sagittal Sinus Thrombosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D006495:Heparin, Low-Molecular-Weight