title: Hemodynamics and gas exchange during experimental one-lung fluid flooding in pigs.
abstract: One-sided fluid flooding of the lung after intubation with a double-lumen tube facilitates pulmonary sonography during surgery. Arterial blood pressure, cardiac index, and heart rate remained unchanged during one-lung fluid flooding in healthy animals. The arterial PO(2) was greater by about 100 mmHg after flooding one lung with 15 ml/kg fluid and ventilation with a FiO(2) of 1.0 compared with total atelectasis. This seems to be identical to a continuos positive airway pressure level of 5 cm H(2)O with pure oxygen on the nonventilated lung. The one-sided fluid flooding induced a statistically significant increase in pulmonary artery pressures and pulmonary capillary wedge pressure. In comparison with total atelectasis, fluid flooding in tendency reduced the pulmonary right-left shunt and increased the arterial PO(2).
authors.affiliation: Department of Anesthesiology and Intensive Therapy, Friedrich-Schiller-Universität Jena, Bachstrasse 18, D-07740, Germany. klinzing@anael.med.uni-jena.de
authors.forename: S
authors.initials: S
authors.lastname: Klinzing
authors.forename: T
authors.initials: T
authors.lastname: Lesser
authors.forename: H
authors.initials: H
authors.lastname: Schubert
authors.forename: F
authors.initials: F
authors.lastname: Bloos
authors.forename: U
authors.initials: U
authors.lastname: Klein
authors.forename: M
authors.initials: M
authors.lastname: Bartel
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004573:Electrolytes; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D008168:Lung / Q000000981:diagnostic imaging / Q000502:physiology* / Q000601:surgery*; D011651:Pulmonary Artery / Q000502:physiology; D011659:Pulmonary Gas Exchange; D011669:Pulmonary Wedge Pressure; D012996:Solutions; D013552:Swine; D014463:Ultrasonography
chemical_list: D004573:Electrolytes; D012996:Solutions