Biochemistry of iron uptake.
Recent information gained from genetic and biochemical studies of iron transport in yeast, coupled with the identification of specific mutations causing iron uptake disorders in mice and man, has provided new clues about the mechanisms involved in iron uptake. This article summarizes these discoveries and discusses their impact on our current understanding of the biochemistry of iron uptake.
Wessling-Resnick
M
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Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
D000818:Animals; D000951:Antigens, Neoplasm; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D027682:Cation Transport Proteins; D002570:Ceruloplasmin / Q000235:genetics / Q000378:metabolism; D000079922:Copper Transport Proteins; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics*; D033862:Iron-Binding Proteins; D008322:Mammals / Q000378:metabolism*; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014168:Transferrin / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism*
D000951:Antigens, Neoplasm; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D000079922:Copper Transport Proteins; C105847:FET4 protein, S cerevisiae; D033862:Iron-Binding Proteins; D058950:Melanoma-Specific Antigens; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009363:Neoplasm Proteins; D029701:Saccharomyces cerevisiae Proteins; D014168:Transferrin; D007501:Iron; D002570:Ceruloplasmin; C085513:FET3 protein, S cerevisiae