title: Second-trimester uterine evacuation: A comparison of intra-amniotic (15S)-15-methyl-prostaglandin F2alpha and intravaginal misoprostol.
abstract: OBJECTIVE
  Our purpose was to compare the efficacy, safety, and adverse effects of intra-amniotically administered (15S)-15-methyl-prostaglandin F(2alpha) and intravaginally administered misoprostol for second-trimester uterine evacuation.
  
  
  METHODS
  Fifty-one patients were randomly assigned to receive either a single 2.5-mg intra-amniotic injection of (15S)-15-methyl-prostaglandin F(2)(alpha) (n = 26) or two 200-microg intravaginal doses of misoprostol (n = 25) at 12-hour intervals. The primary outcome measured was evacuation of the uterus within 24 hours.
  
  
  RESULTS
  The mean time from initiation of termination to uterine evacuation was less in the prostaglandin group than in the misoprostol group (17.5 +/- 8.6 hours vs 22.3 +/- 12.5 hours), but this was not statistically significant (P >.05). The rate of successful fetal evacuation at 24 hours was significantly higher in the prostaglandin group than in the misoprostol group (88% vs 60%, P =.02). The complete-abortion rate and the incidence of adverse effects were similar in both groups.
  
  
  CONCLUSIONS
  The use of an intra-amniotic injection of (15S)-15-methyl-prostaglandin F(2alpha) for midtrimester pregnancy termination is safe and is associated with a greater number of successful uterine evacuations within 24 hours, without an increase in adverse effects, than intravaginal administration of misoprostol.
authors.affiliation: Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Perry
authors.forename: B K
authors.initials: BK
authors.lastname: Rinehart
authors.forename: D A
authors.initials: DA
authors.lastname: Terrone
authors.forename: R W
authors.initials: RW
authors.lastname: Martin
authors.forename: W L
authors.initials: WL
authors.lastname: May
authors.forename: W E
authors.initials: WE
authors.lastname: Roberts
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage* / Q000009:adverse effects*; D000025:Abortion, Eugenic / Q000379:methods*; D000282:Administration, Intravaginal; D000328:Adult; D000650:Amnion; D016063:Blood Loss, Surgical; D002260:Carboprost / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005865:Gestational Age; D006801:Humans; D007267:Injections; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D016896:Treatment Outcome; D014619:Vacuum Curettage
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D002260:Carboprost