title: Anticardiolipin antibodies are an independent risk factor for ischemic stroke.
abstract: Our aim was to determine if anticardiolipin antibodies are an independent risk factor for ischemic stroke and to determine their influence on stroke type and clinical outcome. We prospectively studied 194 consecutive patients with ischemic stroke admitted within 48 h of stroke. A control group consisted of 100, age and sex matched, healthy individuals. Neurological and functional status was assessed on admission, at 30 days, and at 1 year. IgG anticardiolipin antibodies were significantly more frequent in stroke patients (25.3%) than controls (6%, p < 0.05). A multivariate analysis suggested that anticardiolipin antibodies are an independent risk factor for ischemic stroke in addition to hypertension and atrial fibrillation (RR = 2.94, p < 0.05). Elevated IgG anticardiolipin antibodies were associated with cognitive impairment as measured by the Mini Mental State Examination at 30 days and at 1 year. IgG anticardiolipin antibodies did not correlate with stroke recurrence, or mortality at 30 days or 1 year.
authors.affiliation: Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Zieliñska
authors.forename: D
authors.initials: D
authors.lastname: Ryglewicz
authors.forename: E
authors.initials: E
authors.lastname: Wierzchowska
authors.forename: W
authors.initials: W
authors.lastname: Lechowicz
authors.forename: D B
authors.initials: DB
authors.lastname: Hier
authors.forename: A
authors.initials: A
authors.lastname: Czlonkowska
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000453:epidemiology; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D001281:Atrial Fibrillation / Q000453:epidemiology; D002545:Brain Ischemia / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D017153:Antibodies, Anticardiolipin