title: [Sepsis syndrome and bone marrow granulomatosis after intravesical instillation of BCG].
abstract: BACKGROUND
  BCG therapy is an effective treatment for superficial bladder carcinoma. Exceptionally, systemic disorders including hypersensitivity reactions or infections may occur.
  
  
  METHODS
  A 70-year-old man developed septicemia with bone marrow granulomatosis with a favorable course after intravesicle administration of bacillus Calmette-Guérin for bladder carcinoma.
  
  
  CONCLUSIONS
  High grade fever, septicemia, hepatitis or pulmonary granulomatosis as well as bone marrow involvement are reported in less than 1% of all cases of BCG therapy. The pathogenic mechanisms are complex. Anti-tuberculous drugs are generally given.
authors.affiliation: Services de Médecine Interne et Nutrition, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre.
authors.forename: E
authors.initials: E
authors.lastname: Andrès
authors.forename: C
authors.initials: C
authors.lastname: Kuhnert
authors.forename: A E
authors.initials: AE
authors.lastname: Perrin
authors.forename: G
authors.initials: G
authors.lastname: Averous
authors.forename: A
authors.initials: A
authors.lastname: Ruellan
authors.forename: B
authors.initials: B
authors.lastname: Goichot
authors.forename: J L
authors.initials: JL
authors.lastname: Schlienger
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D008297:Male; D009163:Mycobacterium bovis; D018805:Sepsis / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*