title: Secretory carcinoma of the canine mammary gland.
abstract: Secretory carcinoma is an uncommon variant of breast cancer, characterized by the presence of intracellular and extracellular eosinophilic secretion. Here, we report the cytologic, histologic, and immunohistochemical findings of a secretory carcinoma diagnosed in the left inguinal mammary gland of a 3-year-old female German Shepherd Dog. The fine-needle aspiration cytology showed numerous large branching sheets of neoplastic cells and isolated cells with cytoplasmic vacuoles. Histologically, the tumor was composed of cells with clear cytoplasm and prominent vacuoles that pushed the nuclei to the periphery, resembling signet ring cells. These cells were arranged in solid or tubular structures with lumenal spaces filled with eosinophilic secretion. Immunohistochemical reactions to cytokeratin (CAM 5.2) and alpha-lactalbumin were strongly positive in all neoplastic cells, and staining for vimentin and S100 protein was negative. The cytomorphologic and immunohistochemical features of this tumor are similar to those seen in tumors in women, hence enabling the diagnosis of a rare case of primary secretory carcinoma of the canine mammary gland.
authors.affiliation: Department of General Pathology-ICB/UFMG, Belo Horizonte, MG, Brasil. cassalig@mono.icb.ufmg.br
authors.forename: G D
authors.initials: GD
authors.lastname: Cassali
authors.forename: H
authors.initials: H
authors.lastname: Gobbi
authors.forename: F
authors.initials: F
authors.lastname: Gartner
authors.forename: F C
authors.initials: FC
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001707:Biopsy, Needle / Q000662:veterinary; D002277:Carcinoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology; D007768:Lactalbumin / Q000276:immunology; D008321:Mammary Glands, Animal / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D015674:Mammary Neoplasms, Animal / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D009418:S100 Proteins / Q000276:immunology; D014746:Vimentin / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D007768:Lactalbumin