Foreign body infection: a new rat model for prophylaxis and treatment.
A subcutaneous catheter model in the rat was developed that allowed the study of prevention and treatment strategies for foreign body infection. In contrast to earlier models, the foreign body was inoculated with a low inoculum of Staphylococcus epidermidis just before implantation, thus mimicking intraoperative contamination with skin flora. Reproducible infection of all catheters followed if no prophylaxis was given. However, foreign body infection could be prevented or treated with antibiotics such as teicoplanin, which was marginally effective, and rifampicin, which proved very effective.
Van Wijngaerden
E
E
Infectious Diseases Research Group, Departments of Pathophysiology & Microbiology and Immunology, Catholic University of Leuven, Leuven, Belgium. eric.vanwijngaerden@uz.kuleuven.ac.be
Peetermans
W E
WE
Vandersmissen
J
J
Van Lierde
S
S
Bobbaers
H
H
Van Eldere
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004195:Disease Models, Animal; D005547:Foreign Bodies; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000517:prevention & control*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D017334:Teicoplanin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D012293:Rifampin