title: Randomised trial of different rates of feeding in acute diarrhoea.
abstract: OBJECTIVE
  To compare the effect of different feeding frequencies on the speed of recovery from diarrhoea.
  
  
  METHODS
  A randomised, non-blinded trial provided 0.452 MJ/kg/day as either 6 or 12 feeds of cows' milk each day to 262 hospitalised male infants aged 3-12 months with acute diarrhoea. Stool frequency, stool weight, body weight, and diarrhoea complications were monitored until recovery or for 14 days.
  
  
  RESULTS
  A proportional hazards regression model controlling for age, diarrhoea aetiology, and severity of dehydration on admission revealed that the frequently fed group had a significantly shorter duration of diarrhoea (hazards ratio, 1.29; 95% confidence interval, 1.002 to 1.653). Frequently fed infants had a significantly greater weight gain and significantly lower faecal frequency and faecal weight.
  
  
  CONCLUSIONS
  Breast feeding remains the preferred method of feeding infants with acute diarrhoea, but feeding cows' milk to adequately nourished infants with acute diarrhoea is safe and is more rapidly effective if provided in frequent feeds with low energy loads.
authors.affiliation: Departments of Pediatrics and Clinical Epidemiology, West China University of Medical Sciences, Chengdu 610041, People's Republic of China. wangzy_76@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Wan
authors.forename: M R
authors.initials: MR
authors.lastname: Phillips
authors.forename: M J
authors.initials: MJ
authors.lastname: Dibley
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000818:Animals; D003672:Defecation; D003968:Diarrhea, Infantile / Q000178:diet therapy* / Q000503:physiopathology; D005243:Feces; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008297:Male; D008892:Milk; D012044:Regression Analysis; D015430:Weight Gain