Monocyte dysfunction in patients with multiple myeloma and lymphoplasmacytic disorders is related to serum paraprotein levels.
We have investigated monocyte function in 30 patients with lymphoplasmacytic disorders and in 21 age and sex matched normal controls. Marked abnormalities of all facets of monocyte function were demonstrated in six patients with multiple myeloma (MM) and a single patient with Waldenström's macroglobulinaemia (WM) plus significant paraproteinaemia. Serious infection occurred in three of these patients. An inverse relationship between the level of the serum paraprotein and impairment of monocyte phagocytosis plus killing of Candida albicans was observed. Crossover studies suggested that these abnormal findings were constitutive and not reversed by removal of the serum paraprotein. The data suggest that monocyte function is constitutively abnormal in patients with MM and can be further, but reversibly, inhibited by high paraprotein levels. Further research is required to confirm these findings, ascertain whether monocyte function can be normalized using chemotherapy or growth factors, and if so, whether their tumouricidal functions could be harnessed in the treatment of this currently incurable condition.
Mainwaring
C J
CJ
Department of Haematology, Royal United Hospital NHS Trust, Bath.
Williams
M A
MA
Singer
C R
CR
Lush
R J
RJ
Smith
J G
JG
Haynes
C L
CL
Kelsey
S M
SM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D002689:Chlamydia; D005260:Female; D006801:Humans; D007960:Leukocyte Disorders / Q000503:physiopathology*; D008297:Male; D009000:Monocytes / Q000502:physiology*; D009101:Multiple Myeloma / Q000473:pathology; D010265:Paraproteinemias / Q000473:pathology*; D010587:Phagocytosis / Q000502:physiology; D010954:Plasmacytoma / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology
D015815:Cell Adhesion Molecules