title: Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American women.
abstract: The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The median DMFS index was 9 (range 0-68). High levels of S. mutans were positively associated with DRB1*3 and DRB1*4 presence (p < or = 0.005). DRB1*8 was positively associated with higher levels of S. mutans as a percentage of total Streptococci (p = 0.04). DRB1*1 was positively associated with high levels L. casei (p = 0.04). DQB1 alleles were not observed associated with oral bacterial levels. TNFa allele 103 was negatively associated (p = 0.04), and TNFa 117 was positively associated (p = 0.007), with high levels of L. acidophilus. No significant associations were observed between any DRB1, DQB1 or TNFa allele and the DMFS index. These results support an hypothesis of an association between host HLA class II and TNFa genetic profile and colonization of S. mutans, L. casei, and L. acidophilus thought to be pathogens involved in the etiology of dental caries.
authors.affiliation: Department of Microbiology, Schools of Dentistry, Medicine and Public Health, University of Alabama at Birmingham 35294-4400, USA. Acton@iprsh.igpmd.uab.edu
authors.forename: R T
authors.initials: RT
authors.lastname: Acton
authors.forename: A P
authors.initials: AP
authors.lastname: Dasanayake
authors.forename: R A
authors.initials: RA
authors.lastname: Harrison
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: J M
authors.initials: JM
authors.lastname: Roseman
authors.forename: R C
authors.initials: RC
authors.lastname: Go
authors.forename: H
authors.initials: H
authors.lastname: Wiener
authors.forename: P W
authors.initials: PW
authors.lastname: Caufield
mesh_terms: D000293:Adolescent; D000328:Adult; D000407:Alabama / Q000453:epidemiology; D000483:Alleles; D044383:Black People / Q000235:genetics*; D003430:Cross-Sectional Studies; D003731:Dental Caries / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D018895:Microsatellite Repeats; D011247:Pregnancy; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D001741:Black or African American
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D014409:Tumor Necrosis Factor-alpha