Diagnostic molecular pathology comes of age.
Specific and consistent chromosomal translocations, identified in several lymphoreticular, neuroectodermal, and soft tissue neoplasms, generally result in the development of novel fusion transcripts.
el-Naggar
A K
AK
University of Texas, M.D. Anderson Cancer Center, Houston, USA.
D019677:Artificial Gene Fusion; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D004268:DNA-Binding Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000151:congenital / Q000235:genetics* / Q000473:pathology; D008297:Male; D018201:Nephroma, Mesoblastic / Q000151:congenital / Q000235:genetics* / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D020812:Receptor, trkC / Q000235:genetics*; D012097:Repressor Proteins; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
D004268:DNA-Binding Proteins; D015514:Oncogene Proteins, Fusion; D050783:Proto-Oncogene Proteins c-ets; D020812:Receptor, trkC; D012097:Repressor Proteins; D014157:Transcription Factors; D000097764:ETS Translocation Variant 6 Protein