P300 event-related potential and serotonin-1A activity in depression.
The identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.40, P = 0.007 at Cz; r = -0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.
Hansenne
M
M
Psychiatric Unit, CHU Sart Tilman, 4000 Liège, Belgium.
Ansseau
M
M
D000328:Adult; D000928:Antidepressive Agents; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000378:metabolism*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines; D011388:Prolactin / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists
D000928:Antidepressive Agents; D010879:Piperazines; D017366:Serotonin Receptor Agonists; D012701:Serotonin; C056895:flesinoxan; D011388:Prolactin