title: Genetically distinct dog-derived and human-derived Sarcoptes scabiei in scabies-endemic communities in northern Australia.
abstract: Overcrowding is a significant factor contributing to endemic infection with Sarcoptes scabiei in human and animal populations. However, since scabies mites from different host species are indistinguishable morphologically, it is unclear whether people can be infected from scabies-infested animals. Molecular fingerprinting was done using three S. scabiei-specific single locus hypervariable microsatellite markers, with a combined total of 70 known alleles. Multilocus analysis of 712 scabies mites from human and dog hosts in Ohio, Panama and Aboriginal communities in northern Australia now shows that genotypes of dog-derived and human-derived scabies cluster by host species rather than by geographic location. Because of the apparent genetic separation between human scabies and dog scabies, control programs for human scabies in endemic areas do not require resources directed against zoonotic infection from dogs.
authors.affiliation: Menzies School of Health Research, Darwin, Northern Territory, Australia.
authors.forename: S F
authors.initials: SF
authors.lastname: Walton
authors.forename: J L
authors.initials: JL
authors.lastname: Choy
authors.forename: A
authors.initials: A
authors.lastname: Bonson
authors.forename: A
authors.initials: A
authors.lastname: Valle
authors.forename: J
authors.initials: J
authors.lastname: McBroom
authors.forename: D
authors.initials: D
authors.lastname: Taplin
authors.forename: L
authors.initials: L
authors.lastname: Arlian
authors.forename: J D
authors.initials: JD
authors.lastname: Mathews
authors.forename: B
authors.initials: B
authors.lastname: Currie
authors.forename: D J
authors.initials: DJ
authors.lastname: Kemp
mesh_terms: D000483:Alleles; D000818:Animals; D016000:Cluster Analysis; D004247:DNA / Q000737:chemistry; D016172:DNA Fingerprinting / Q000662:veterinary; D018900:Dinucleotide Repeats / Q000235:genetics; D004197:Disease Reservoirs; D004283:Dog Diseases / Q000453:epidemiology / Q000469:parasitology*; D004285:Dogs; D004586:Electrophoresis / Q000662:veterinary; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008394:Marsupialia; D015876:Northern Territory / Q000453:epidemiology; D009820:Ohio / Q000453:epidemiology; D010176:Panama / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011817:Rabbits; D012520:Sarcoptes scabiei / Q000235:genetics*; D012532:Scabies / Q000453:epidemiology / Q000469:parasitology*; D012867:Skin / Q000469:parasitology; D014739:Victoria / Q000453:epidemiology; D015047:Zoonoses
chemical_list: D004247:DNA