Characterization of the mouse Kid1 gene and identification of a highly related gene, Kid2.
Kid1 encodes a zinc finger protein that has been implicated in renal cell differentiation. Levels of Kid1 mRNA correlate with maturation of kidney tubule epithelia in rat post-natal kidney development and during kidney regeneration following injury. KID1 is a putative transcriptional repressor, containing a KRAB domain at its amino terminus that mediates transcriptional repression in transient cell transfection assays when fused to a heterologous DNA-binding domain. In this paper, we describe the isolation and characterization of the mouse homologue of Kid1 and the identification of a novel highly related mouse gene, Kid2, Kid1 and Kid2 are tightly linked on mouse chromosome 11 and show conservation across mammals. Both genes are expressed predominantly in the mouse adult kidney and brain, but transcripts are also detected in embryonic brain, kidney, gut and lung, suggesting an additional role for these genes during mouse development.
Tekki-Kessaris
N
N
University of Cambridge, Department of Genetics, Downing Street, Cambridge, UK.
Bonventre
J V
JV
Boulter
C A
CA
D000595:Amino Acid Sequence; D000818:Animals; D002415:Cats; D002874:Chromosome Mapping; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics*; D004622:Embryo, Mammalian / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005796:Genes / Q000235:genetics*; D000882:Haplorhini; D006801:Humans; D008297:Male; D008322:Mammals / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012756:Sheep; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C410184:ZNF354A protein, human; C485822:Zfp354a protein, mouse; C485823:Zfp354a protein, rat; C402624:Zfp354b protein, mouse; D004247:DNA