Synthesis and preliminary in vitro cytotoxic activity of novel cisplatin and carboplatin analogues.
Six new platinum(II) complexes were synthesized from a common triphenylethylene precursor using various diamines. The cytotoxicity of the compounds, evaluated on human breast cancer cell lines (MCF-7 and MDA-MB-231), was greatly influenced by the nature of the diamine ligand. Two derivatives presented cytotoxic activity greater than tamoxifen and, for the first time, as potent as cisplatin.
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Département de Chimie-Biologie, Université du Québec à Trois-Rivières, Québec, Canada.
Bérubé
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Gaudreault
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D000970:Antineoplastic Agents / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D016190:Carboplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D017671:Platinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013267:Stilbenes / Q000737:chemistry; D013629:Tamoxifen / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003959:Diamines; D017671:Platinum Compounds; D013267:Stilbenes; D013629:Tamoxifen; D016190:Carboplatin; D002945:Cisplatin; C037749:triphenylethylene