title: Effect of perezone on arrhythmias and markers of cell injury during reperfusion in the anesthetized rat.
abstract: In the in vivo rat heart model with transient (5 min) regional ischemia, as induced by left coronary artery ligation, we have demonstrated that perezone reduces dramatically the incidence of reperfusion-induced-arrhythmias. Administered 5 minutes before coronary occlusion, at a dose of 3.1 mg/kg, this drug effectively protects against the high incidence of arrhythmias and the fall of blood pressure. In addition, it inhibits the release of lactic dehydrogenase and creatine-kinase enzymes to the plasma. We propose that the protective effect of perezone might be related to its well documented action of promoting the release of intramitochondrial Ca2+, thus, maintaining ATP production during reperfusion.
authors.affiliation: Departamento de Bioquímica, Instituto Nacional de Cardiologia Ignacio Chávez, Facultad de Medicina UNAM, DF, México.
authors.forename: J F
authors.initials: JF
authors.lastname: Téllez
authors.forename: K
authors.initials: K
authors.lastname: Carvajal
authors.forename: D
authors.initials: D
authors.lastname: Cruz
authors.forename: A
authors.initials: A
authors.lastname: Cárabez
authors.forename: E
authors.initials: E
authors.lastname: Chávez
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000201:enzymology / Q000473:pathology* / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D012717:Sesquiterpenes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; C053752:perezone