Biotransformation of N-acetylphenothiazine by fungi.
Cultures of the fungi Aspergillus niger, Cunninghamella verticillata, and Penicillium simplicissimum, grown in a sucrose/peptone medium, transformed N-acetylphenothiazine to N-acetylphenothiazine sulfoxide (from 13% to 28% of the total) and phenothiazine sulfoxide (from 5% to 27%). Phenothiazin-3-one (4%) and phenothiazine N-glucoside (4%) were also produced by C. verticillata. The probable intermediate, phenothiazine, was detected only in cultures of P. simplicissimum (6%).
Parshikov
I A
IA
Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
Freeman
J P
JP
Williams
A J
AJ
Moody
J D
JD
Sutherland
J B
JB
D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D020093:Cunninghamella / Q000378:metabolism; D005658:Fungi / Q000378:metabolism*; D010407:Penicillium / Q000378:metabolism; D010640:Phenothiazines / Q000493:pharmacokinetics*; D013454:Sulfoxides / Q000032:analysis
D010640:Phenothiazines; D013454:Sulfoxides; C012546:2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine