title: Xylene-induced effects on brain neurotransmitters, behavior and fos protein in rats.
abstract: Male Sprague-Dawley rats administered xylene intraperitoneally on alternate days at a dose of 125 or 250 mg/kg for 30 days exhibited no marked changes in locomotor activity, learning and memory capacity. However in rats given xylene on alternate day at a dose of 500 mg/kg for 30 days, a significant decrease in locomotor activity, deficits in learning ability and memory loss were detected. These xylene-induced behavioral changes were associated with a decrease in beta-endorphin and leuenkaphlin concentrations in the pons-medulla. On the contrary, xylene at a dose of 500 mg/kg increased the beta-endorphin level in caudate and c-fos expression in hippocampus. These data suggest that the xylene-induced behavioral alterations might be associated with the expression of Fos protein in the hippocampus.
authors.affiliation: Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China. xiulingwang@263.net
authors.forename: X L
authors.initials: XL
authors.lastname: Wang
authors.forename: X P
authors.initials: XP
authors.lastname: Jin
authors.forename: H
authors.initials: H
authors.lastname: Fu
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Chen
authors.forename: C D
authors.initials: CD
authors.lastname: Da
authors.forename: X F
authors.initials: XF
authors.lastname: Huang
authors.forename: B Q
authors.initials: BQ
authors.lastname: Ding
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007263:Infusions, Parenteral; D007858:Learning / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014992:Xylenes / Q000009:adverse effects*
chemical_list: D018377:Neurotransmitter Agents; D016760:Proto-Oncogene Proteins c-fos; D014992:Xylenes