title: Intravenous administration of hypertonic sodium chloride solution with dextran or isotonic sodium chloride solution for treatment of septic shock secondary to pyometra in dogs.
abstract: OBJECTIVE
  To determine effects of i.v. administration of hypertonic saline (7.5% NaCl) solution with 6% dextran 70 (HSSD) or isotonic saline (0.9% NaCl) solution (ISS) to dogs with septic shock secondary to pyometra.
  
  
  METHODS
  Prospective, randomized, clinical study.
  
  
  METHODS
  14 client-owned dogs with septic shock secondary to pyometra.
  
  
  METHODS
  Prior to emergency ovariohysterectomy, catheters were placed in pulmonary and femoral arteries of each dog to evaluate hemodynamic and oxygenation status. Immediately prior to surgery, 7 dogs received HSSD (4 ml/kg [1.82 ml/lb] of body weight, i.v.) and 7 dogs received ISS (32 ml/kg [14.54 ml/lb], i.v.) during a 5-minute period. Measurements of hemodynamic and oxygenation variables were obtained before and 5 and 20 minutes after administration of fluids.
  
  
  RESULTS
  Mean arterial pressure (MAP) increased significantly 5 and 20 minutes after administration of HSSD, whereas ISS did not affect MAP. However, cardiac output, cardiac index, and oxygen delivery increased and hematocrit decreased after both treatments. Oxygen consumption and extraction rate and degree of acidosis did not improve after either treatment.
  
  
  CONCLUSIONS
  Intravenous administration of small volumes of HSSD to dogs with septic shock secondary to pyometra resulted in improvement of hemodynamic and oxygenation status. Although cardiac output, cardiac index, and oxygen delivery improved after administration of a volume of ISS equal to 8 times that of HSSD, MAP increased to > 80 mm Hg only after treatment with HSSD. Administration of HSSD may be an effective treatment for septic shock in dogs.
authors.affiliation: Department of Surgery, College of Veterinary Medicine, University of São Paulo, Brazil.
authors.forename: D T
authors.initials: DT
authors.lastname: Fantoni
authors.forename: J O
authors.initials: JO
authors.lastname: Auler Junior
authors.forename: F
authors.initials: F
authors.lastname: Futema
authors.forename: S R
authors.initials: SR
authors.lastname: Cortopassi
authors.forename: E R
authors.initials: ER
authors.lastname: Migliati
authors.forename: M
authors.initials: M
authors.lastname: Faustino
authors.forename: C M
authors.initials: CM
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D003911:Dextrans / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D004285:Dogs; D005260:Female; D006982:Hypertonic Solutions; D007044:Hysterectomy / Q000662:veterinary; D007552:Isotonic Solutions; D010052:Ovariectomy / Q000662:veterinary; D010100:Oxygen / Q000378:metabolism; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011446:Prospective Studies; D012772:Shock, Septic / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000627:therapeutic use*; D013492:Suppuration / Q000150:complications / Q000662:veterinary; D014554:Urination; D014591:Uterine Diseases / Q000150:complications / Q000601:surgery / Q000662:veterinary*
chemical_list: D003911:Dextrans; D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D012965:Sodium Chloride; D010100:Oxygen