title: Stabilizing potential of anterior cervical plates in multilevel corpectomies.
abstract: METHODS
  An in vitro investigation of three-dimensional kinematics of cervical spine models of one- and three-level corpectomy with anterior plate fixation.
  
  
  OBJECTIVE
  To evaluate the capability of an anterior plate to stabilize the reconstructed cervical spine under simulated physiologic motions, and to study the effects of fatigue loading.
  
  
  BACKGROUND
  Clinical studies have found high failure rates of multilevel anterior cervical plate fusions, indicating suboptimal stabilization. However, no biomechanical studies have been done to investigate the stabilizing capabilities of long-plate instrumentations in corpectomy models.
  
  
  METHODS
  Seven fresh human cadaveric cervical spine specimens (C2-T1) were used. Flexibility tests consisted of flexion, extension, and bilateral torsion, and lateral bending, each with a pure moment of 0.25, 0.5, 0.75, and 1.0 Nm. Stabilizing potential indices [(MotionIntact-MotionInstrumented)/MotionIntact] for ranges of motion and neutral zones obtained from the flexibility tests, were measured when the specimen was intact and after one-level (C5) and three-level (C4, C5, and C6) corpectomies and anterior plate stabilizations). The stabilizing potential indices were re-measured after a 1000-cycle fatigue loading (1 Nm flexion and extension moments at C5 vertebra at 0.14 Hz).
  
  
  RESULTS
  The differences in stabilizing potential indices of range of motion and neutral zone between one-level and three-level plates were not significant before fatigue. However, after fatigue, the stabilizing potential indices significantly decreased (P < 0.05) for the three-level model, but not for the one-level plate model.
  
  
  CONCLUSIONS
  The capability of an anterior cervical plate to stabilize the spine after three-level corpectomy was significantly reduced with fatigue loading.
authors.affiliation: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: T
authors.initials: T
authors.lastname: Isomi
authors.forename: M M
authors.initials: MM
authors.lastname: Panjabi
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.forename: A R
authors.initials: AR
authors.lastname: Vaccaro
authors.forename: S R
authors.initials: SR
authors.lastname: Garfin
authors.forename: T
authors.initials: T
authors.lastname: Patel
mesh_terms: D000293:Adolescent; D000328:Adult; D001860:Bone Plates; D002574:Cervical Vertebrae / Q000601:surgery*; D015775:Fractures, Stress / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D014102:Torsion Abnormality; D016474:Weight-Bearing