title: Invasive squamous cell carcinoma with sporotrichoid metastasis in a patient with cutaneous T cell lymphoma treated with chronic extracorporeal photopheresis.
abstract: An 83-year-old Caucasian man with cutaneous T-cell lymphoma developed an aggressive squamous cell carcinoma of the left forearm, which recurred and metastasized after Mohs micrographic surgery and systemic chemotherapy with cis-platin and 5-fluorouracil. He was treated with extracorporeal photopheresis, radiation therapy, PUVA photochemotherapy, and interferon therapy for cutaneous T-cell lymphoma. Aggressive squamous cell carcinoma can occur in the setting of extracorporeal photopheresis.
authors.affiliation: Department of Dermatology, New York-Presbyterian Hospital, Columbia Presbyterian Center, New York, USA.
authors.forename: R
authors.initials: R
authors.lastname: Gmyrek
authors.forename: R
authors.initials: R
authors.lastname: Beer
authors.forename: Y
authors.initials: Y
authors.lastname: Elizeri
authors.forename: M W
authors.initials: MW
authors.lastname: Oster
authors.forename: D N
authors.initials: DN
authors.lastname: Silvers
authors.forename: P
authors.initials: P
authors.lastname: Schneiderman
authors.forename: M E
authors.initials: ME
authors.lastname: Grossman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000379:methods; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000556:secondary* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000628:therapy*; D008297:Male; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local / Q000556:secondary* / Q000601:surgery; D017893:Photopheresis / Q000009:adverse effects* / Q000379:methods; D012878:Skin Neoplasms / Q000209:etiology* / Q000628:therapy; D012883:Skin Ulcer / Q000209:etiology*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil