[Experimental research on the use of deferoxamine in the prevention of renal damage from acute ischemia].
Oxygen free-radical reperfusion products play a critical role in postischemic tissues injury. In this study we used deferoxamine, an iron ligand that seems to inhibit hydroxyl radicals production, in renal normothermic acute ischemia in the rat. Our results demonstrated a significant protective effect of deferoxamine on kidneys subjected to normothermic acute ischemia.
Libra
S
S
Dipartimento di Chirurgia, Università di Catania.
Pagano
D
D
Curella
G
G
Litrico
V
V
Cancelliere
M
M
Audibert
D
D
La Terra
S
S
Gruttadauria
S
S
Pappalardo
A
A
D'Alessandro
M
M
D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D003676:Deferoxamine / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D007511:Ischemia / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007502:Iron Chelating Agents; D003676:Deferoxamine