Role of cytokines in the metabolic response to stress.
Clinical trials with cytokine inhibitors have failed to show efficacy and confirm preclinical findings in sepsis and systemic inflammatory response syndromes. However, a better understanding of the pathogenesis of sepsis syndrome, and of proinflammatory cytokine signal transduction pathways, including the role of nuclear factor kappa B and inflammation-induced apoptosis, have provided new therapeutic opportunities for cytokine and anticytokine therapies.
Edwards
P D
PD
Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.
Moldawer
L L
LL
D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000503:physiopathology* / Q000628:therapy*; D016328:NF-kappa B / Q000378:metabolism; D018805:Sepsis / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D015398:Signal Transduction; D013312:Stress, Physiological / Q000503:physiopathology*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha