[The pharmacological correction of the immune homeostasis disorders in acute dichloroethane poisoning].
Experiments on Wistar rats and noninbred mice showed that dipyroxim (10 mg/kg administered 3 times per 24 h) and thymogen (10 mg/kg daily for 3 days) restore the reduced under the effect of acute dichlorethane poisoning in a dose of 0.75 LD50 the organism's anti-infectious unspecific resistance and the main humoral and cell immune reactions. Summing of the effects of the drugs under study was encountered in the case of the T-dependent humoral immune response. The effect of dipyroxim was due to restoration of alpha-naphthyl-AS-acetatesterase of immunocytes and, possibly, other types of esterases of T-cells, macrophages, and monocytes.
Zabrodskiĭ
P F
PF
Department of Toxicology, Saratov Medical University, Russia.
Gryzunov
A V
AV
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000931:Antidotes / Q000008:administration & dosage; D002801:Cholinesterase Reactivators / Q000008:administration & dosage; D004151:Dipeptides; D004353:Drug Evaluation, Preclinical; D005025:Ethylene Dichlorides / Q000506:poisoning*; D006706:Homeostasis / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice; D010455:Peptides / Q000008:administration & dosage; D011041:Poisoning / Q000188:drug therapy / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014289:Trimedoxime / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D000931:Antidotes; D002801:Cholinesterase Reactivators; D004151:Dipeptides; D005025:Ethylene Dichlorides; D010455:Peptides; C060736:thymogen; D014289:Trimedoxime