title: The importance of the proportion of heme/nonheme iron in the diet to minimize the interference with calcium, phosphorus, and magnesium metabolism on recovery from nutritional ferropenic anemia.
abstract: The digestive utilization of Fe and its nutritive interaction with Ca, P, and Mg were studied in rats with nutritional ferropenic anemia. The diet contained 80% ferric citrate and 20% heme iron (80/20 diet). The weight gain, digestive utilization of Fe, and regeneration efficiency of hemoglobin and seric Fe were higher in iron-deficient rats (ID) fed the 80/20 diet than in iron-deficient rats fed the 50/50 diet (Campos et al., 1996). The phospho-calcic metabolism, which is adversely affected in ferropenic anemia, returned to normal values when iron was added to the diet. The digestive utilization of Mg, which fell with the 50/50 diet (Campos et al., 1996), returned to normal values when the ferropenic anemia was reversed with the 80/20 diet. In a state of iron deficiency, certain parameters related to the glucose and lipid metabolism are affected; the glucose and triglycerides values return to a normal range with the 80/20 diet.
authors.affiliation: Departamento de Fisiología e Instituto de Nutrición y Technologia de Alimentos, Facultad de Farmacia, Universidad de Granada, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lisbona
authors.forename: M D
authors.initials: MD
authors.lastname: Reyes-Andrada
authors.forename: I
authors.initials: I
authors.lastname: López-Aliaga
authors.forename: M
authors.initials: M
authors.lastname: Barrionuevo
authors.forename: M J
authors.initials: MJ
authors.lastname: Alférez
authors.forename: M S
authors.initials: MS
authors.lastname: Campos
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000178:diet therapy*; D000821:Animal Feed; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004063:Digestion; D006418:Heme; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron; D008099:Liver / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D051381:Rats
chemical_list: D006454:Hemoglobins; D010710:Phosphates; D006418:Heme; D007501:Iron; D008274:Magnesium; D002118:Calcium