Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.
In a pilot study on the first application of Propofol 6% SAZN in humans, the pharmacokinetics and safety of the new product seem to be similar to those of Propofol 1% SAZN and Diprivan-10 after bolus injection. The results will have to be confirmed in a larger clinical study in order to develop Propofol 6% SAZN as an alternative for Diprivan-10.
Knibbe
C A
CA
Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.
Koster
V S
VS
Aarts
L P
LP
Langemeijer
H J
HJ
Danhof
M
M
D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000493:pharmacokinetics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D015742:Propofol / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors
D018686:Anesthetics, Intravenous; D015742:Propofol