title: Analysis of GB virus C markers in families over three generations.
abstract: GB virus C (GBV-C) markers were analyzed in two to three generations in three families with documented vertical transmission of GBV-C. None of the maternal grandparents had GBV-C markers, whereas the male spouses had GBV-C envelope 2 antibodies. Evidence was found for intrafamilial transmission but not for GBV-C transmission over three generations.
authors.affiliation: Divisions of Clinical Virology and Basic Oral Science, Karolinska Institutet at Huddinge University Hospital, S-141 86 Huddinge, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Fischler
authors.forename: C
authors.initials: C
authors.lastname: Hultgren
authors.forename: R
authors.initials: R
authors.lastname: Halasz
authors.forename: A
authors.initials: A
authors.lastname: Nemeth
authors.forename: M
authors.initials: M
authors.lastname: Sällberg
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D002648:Child; D005190:Family; D005260:Female; D018067:Flaviviridae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000635:transmission* / Q000821:virology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012463:Saliva / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C