title: A case of interstitial pneumonia associated with Pneumocystis carinii in a foal.
abstract: Subacute interstitial pneumonia with diffuse alveolar damage, marked macrophage infiltration, and intracellular Pneumocystis carinii cysts is described in a 3-month-old Swiss warmblood foal. Clinically, the disease was characterized by sudden onset of respiratory distress with fatal outcome. Based on serum immunoglobulin G (IgG), IgA, and IgM values, no humoral immunosuppression was detected. Spleen, thymus, and bronchial lymph nodes did not reveal lymphoid depletion, as assessed by immunohistochemical staining of CD-3-positive cells. Immunopathogenesis of pulmonary infections with intracellular agents in foals is discussed.
authors.affiliation: Département Hippique, Ecole Nationale Vétérinaire de Lyon, Marcy l'Etoile, France.
authors.forename: M F
authors.initials: MF
authors.lastname: Perron Lepage
authors.forename: V
authors.initials: V
authors.lastname: Gerber
authors.forename: M M
authors.initials: MM
authors.lastname: Suter
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000382:microbiology* / Q000473:pathology; D006736:Horses; D007136:Immunoglobulins / Q000097:blood; D007150:Immunohistochemistry; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008198:Lymph Nodes / Q000276:immunology; D011010:Pneumocystis / Q000187:drug effects / Q000472:pathogenicity*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D007136:Immunoglobulins