CD30/CD30 ligand and CD40/CD40 ligand in malignant lymphoid disorders.
CD30 and CD40 are members of the tumor necrosis factor (TNF) receptor family. These two receptors have pleiotropic biologic functions including induction of apoptosis and enhancing cell survival. This review will discuss the pattern of expression of these receptors in malignant lymphoid disorders and their prospective ligands. Understanding issues related to these two ligands and their receptors in lymphoid malignancies may help to improve the classification of these diseases and could open the doors for new treatment strategies.
Younes
A
A
Department of Lymphoma, U.T.M.D. Anderson Cancer Center, Houston, USA.
Carbone
A
A
D053285:CD30 Ligand; D019013:CD40 Antigens / Q000032:analysis*; D023201:CD40 Ligand; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D008223:Lymphoma / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000032:analysis*
D053285:CD30 Ligand; D019013:CD40 Antigens; D017730:Ki-1 Antigen; D008562:Membrane Glycoproteins; C505774:TNFSF8 protein, human; D023201:CD40 Ligand