Invasive squamous cell carcinoma with sporotrichoid metastasis in a patient with cutaneous T cell lymphoma treated with chronic extracorporeal photopheresis.
An 83-year-old Caucasian man with cutaneous T-cell lymphoma developed an aggressive squamous cell carcinoma of the left forearm, which recurred and metastasized after Mohs micrographic surgery and systemic chemotherapy with cis-platin and 5-fluorouracil. He was treated with extracorporeal photopheresis, radiation therapy, PUVA photochemotherapy, and interferon therapy for cutaneous T-cell lymphoma. Aggressive squamous cell carcinoma can occur in the setting of extracorporeal photopheresis.
Gmyrek
R
R
Department of Dermatology, New York-Presbyterian Hospital, Columbia Presbyterian Center, New York, USA.
Beer
R
R
Elizeri
Y
Y
Oster
M W
MW
Silvers
D N
DN
Schneiderman
P
P
Grossman
M E
ME
D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical / Q000379:methods; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000556:secondary* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000628:therapy*; D008297:Male; D015580:Mohs Surgery; D009364:Neoplasm Recurrence, Local / Q000556:secondary* / Q000601:surgery; D017893:Photopheresis / Q000009:adverse effects* / Q000379:methods; D012878:Skin Neoplasms / Q000209:etiology* / Q000628:therapy; D012883:Skin Ulcer / Q000209:etiology*
D002945:Cisplatin; D005472:Fluorouracil