title: Biotransformation of N-acetylphenothiazine by fungi.
abstract: Cultures of the fungi Aspergillus niger, Cunninghamella verticillata, and Penicillium simplicissimum, grown in a sucrose/peptone medium, transformed N-acetylphenothiazine to N-acetylphenothiazine sulfoxide (from 13% to 28% of the total) and phenothiazine sulfoxide (from 5% to 27%). Phenothiazin-3-one (4%) and phenothiazine N-glucoside (4%) were also produced by C. verticillata. The probable intermediate, phenothiazine, was detected only in cultures of P. simplicissimum (6%).
authors.affiliation: Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Parshikov
authors.forename: J P
authors.initials: JP
authors.lastname: Freeman
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: J D
authors.initials: JD
authors.lastname: Moody
authors.forename: J B
authors.initials: JB
authors.lastname: Sutherland
mesh_terms: D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D020093:Cunninghamella / Q000378:metabolism; D005658:Fungi / Q000378:metabolism*; D010407:Penicillium / Q000378:metabolism; D010640:Phenothiazines / Q000493:pharmacokinetics*; D013454:Sulfoxides / Q000032:analysis
chemical_list: D010640:Phenothiazines; D013454:Sulfoxides; C012546:2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine