Derivative (1;7)(q10;p10) in a patient with de novo acute erythroblastic leukemia (AML-M6).
A rare association of der(1;7)(q10;p10) with de novo acute erythroblastic leukemia (AML-M6) in a 63-year-old male is reported. While this unbalanced 1;7 translocation, der(1;7), has been reported often in therapy-related myelodysplastic syndrome (t-MDS) or therapy-related acute myeloid leukemia (t-AML), its associations with de novo AML-FAB-M6 have rarely been reported. Although der(1;7) has been reported as a cytogenetic factor for poor prognosis in t-MDS/AML, our patient showed a good response to chemotherapy and obtained complete remission, although longer observation is required to evaluate the prognosis.
Obara
N
N
Department of Medicine, Tsukuba Memorial Hospital, Japan.
Shinagawa
A
A
Komatsu
T
T
Abe
T
T
Ninomiya
H
H
D000368:Aged; D001854:Bone Marrow Cells / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics* / Q000473:pathology; D016131:Lymphocyte Subsets; D008297:Male; D014178:Translocation, Genetic