title: [Mobilization of alpha-glutathione S-transferase in the anesthetized patient].
abstract: OBJECTIVE
  To measure and assess changes in plasma concentrations of alpha glutathione S-transferase (alpha-GST) during and after anesthesia with isoflurane, desflurane and propofol.
  
  
  METHODS
  Study of 90 ASA I and II patients scheduled for lumbar back surgery under general anesthesia assigned randomly to one of three groups to receive anesthetic maintenance with isoflurane, desflurane or propofol. We measured plasma levels of alpha-GST, aspartate aminotransferase aspartate, alanine aminotransferase, alkaline phosphatase, pseudocholinesterase, gamma glutamyltransferase and total bilirubin at baseline and several times during and after surgery.
  
  
  RESULTS
  Changes in plasma levels of alpha-GST were detected in all three groups, the tendency to increase reaching its peak with the sample taken at the end of anesthesia. The ranges considered normal were not exceeded in any of the patients studied.
  
  
  CONCLUSIONS
  By measuring alpha-GST changes in plasma, we have detected signs of disturbance in hepatocellular integrity after anesthesia with all three maintenance agents used. However, the slight and transitory nature of the events confirms the scarce hepatotoxic potential of isoflurane, desflurane and propofol.
authors.affiliation: Departamento de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital de Rehabilitación y Traumatología, Ciudad Sanitaria Virgen del Rocío de Sevilla.
authors.forename: L M
authors.initials: LM
authors.lastname: Granados Llamas
authors.forename: E
authors.initials: E
authors.lastname: Navas Rivera
authors.forename: M L
authors.initials: ML
authors.lastname: Marenco de la Fuente
authors.forename: R
authors.initials: R
authors.lastname: Balanza Ortiz
authors.forename: F
authors.initials: F
authors.lastname: Suárez Collazos
authors.forename: J J
authors.initials: JJ
authors.lastname: Puente Egido
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000768:Anesthesia, General / Q000009:adverse effects; D000777:Anesthetics / Q000633:toxicity*; D018685:Anesthetics, Inhalation / Q000633:toxicity; D018686:Anesthetics, Intravenous / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology; D000077335:Desflurane; D004789:Enzyme Activation / Q000187:drug effects*; D005260:Female; D005982:Glutathione Transferase / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000633:toxicity
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000077335:Desflurane; D007530:Isoflurane; D005982:Glutathione Transferase; D015742:Propofol