title: Total cavopulmonary and atriopulmonary connections are associated with reduced heart rate variability.
abstract: OBJECTIVE
  To determine whether cavopulmonary connections are associated with abnormalities of heart rate variability.
  
  
  METHODS
  Heart rate variability was studied by 24 hour Holter monitoring in 39 patients (mean (SD) age 12.2 (4.1) years) who underwent cavopulmonary connection operations (partial in 12, total in 13, and atriopulmonary in 14). Two control groups were used: 18 healthy children (11.1 (2.5) years) and 16 patients (11.7 (4.3) years) undergoing cardiovascular surgery for biventricular repair of congenital heart disease. All patients were in sinus rhythm and had normal left ventricular function. Four time domain indices were calculated: mean duration of RR intervals (RR), standard deviation of all RR intervals (SD), square root of the mean squared differences of successive RR intervals (r-MSSD), and percentage differences of successive RR intervals of > 50 ms duration (pNN50). Four frequency domain indices were calculated: total power (TP), low frequency (LF), high frequency (HF), and the LF:HF ratio.
  
  
  RESULTS
  Heart rate variability indices were identical in the two control groups. Significantly reduced heart rate variability was found in patients with total cavopulmonary connections and atriopulmonary connections compared with the two control groups. In patients with partial cavopulmonary connections, heart rate variability was reduced compared with healthy controls. No differences in heart rate variability could be related to clinical status (New York Heart Association functional class), number of surgical interventions, or presence of right atrial enlargement.
  
  
  CONCLUSIONS
  Patients with cavopulmonary connections have significantly reduced heart rate variability and a particularly low vagal drive.
authors.affiliation: Service de Cardiologie Pediatrique, 149 Rue de Sevres, 75015 Paris, France. Gianfra.but@mailcity.com
authors.forename: G
authors.initials: G
authors.lastname: Butera
authors.forename: D
authors.initials: D
authors.lastname: Bonnet
authors.forename: L
authors.initials: L
authors.lastname: Iserin
authors.forename: D
authors.initials: D
authors.lastname: Sidi
authors.forename: J
authors.initials: J
authors.lastname: Kachaner
authors.forename: E
authors.initials: E
authors.lastname: Villain
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002648:Child; D015716:Electrocardiography, Ambulatory; D018729:Fontan Procedure / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000503:physiopathology* / Q000601:surgery*; D006339:Heart Rate; D006801:Humans