title: An MRI study of the corpus callosum and cerebellum in mentally retarded autistic individuals.
abstract: The areas of seven subregions of the corpus callosum and three subregions of the cerebellum were examined on midsagittal magnetic resonance imaging scans of 27 low-IQ autistic individuals and 17 nonautistic individuals of comparable mental age. Autistic individuals had a significantly smaller corpus callosum (most marked in the body). No significant between-group differences were found in cerebellum areas. Results demonstrate that abnormalities of the corpus callosum reported in high-functioning autistic individuals are also present in autistic individuals with mental retardation and extend previous reports showing no evidence for a selective hypoplasia of cerebellar lobules VI-VII.
authors.affiliation: Department of Neuropsychiatry, Raúl Carrea Institute of Neurological Research-FLENI, Buenos Aires, Argentina.
authors.forename: F
authors.initials: F
authors.lastname: Manes
authors.forename: J
authors.initials: J
authors.lastname: Piven
authors.forename: D
authors.initials: D
authors.lastname: Vrancic
authors.forename: V
authors.initials: V
authors.lastname: Nanclares
authors.forename: C
authors.initials: C
authors.lastname: Plebst
authors.forename: S E
authors.initials: SE
authors.lastname: Starkstein
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder; D002531:Cerebellum / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D008279:Magnetic Resonance Imaging; D008297:Male