Evaluation of long-term administration of the antioxidant stobadine on exploratory behaviour in rats of both genders.
Stobadine (STO) is a prospective neuro- and cardioprotective drug with high antioxidative properties. The aim of this study was to ascertain the effect of long-term administration of STO on exploratory behaviour and habituation processes in adult virgin female and male rats. Stobadine was administered by oral gavage in a single dose of 50 mg kg(-1) day(-1) for a total of 56 days. The animals were tested for exploratory behaviour-intensity of motor and vertical activity in an open field test in three blocks of measurements (initial screening; after 56 days of STO administration; and 28 days after the last treatment). The rate of decline of motor activity was evaluated during four consecutive days of testing (interrupted habituation). Administration of STO resulted in transient inhibition of exploratory behaviour in female rats without overtly detectable toxicity. Exploratory behaviour of males was not affected by STO treatment.
Dubovický
M
M
Institute of Experimental Pharmacology SASc, Dúbravská cesta 9, 842 16 Bratislava, Slovak Republic.
Ujházy
E
E
Kovacovský
P
P
Rychlík
I
I
Jansák
J
J
D000818:Animals; D000975:Antioxidants / Q000633:toxicity*; D002243:Carbolines / Q000633:toxicity*; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012727:Sex Characteristics
D000975:Antioxidants; D002243:Carbolines; C100106:dicarbine