title: Excavatolides U-Z, new briarane diterpenes from the gorgonian briareum excavatum
abstract: A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U-Z (1-6). The structures and relative stereochemistry of metabolites 1-6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.
authors.affiliation: Department of Marine Resources and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.
authors.initials: JH
authors.lastname: Sheu
authors.initials: PJ
authors.lastname: Sung
authors.initials: JH
authors.lastname: Su
authors.initials: GH
authors.lastname: Wang
authors.initials: CY
authors.lastname: Duh
authors.initials: YC
authors.lastname: Shen
authors.initials: MY
authors.lastname: Chiang
authors.initials: IT
authors.lastname: Chen