Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination.
Antisense technology provides a high-throughput and systematic approach to drug target validation and gene function discovery. In combination with other emerging technologies (such as microarrays), this technology will enable efficient evaluation of the sequence data generated by the Human Genome Project. The authors review recent advances in the antisense field and discuss the potential use of antisense technology for functional genomics.
Taylor
MF
Sequitur, 4 Mechanic Street, Suite 210, Natick, MA 01760, USA.
Wiederholt
K
Sverdrup
F