title: Enantioselective Total Synthesis of the Nonisoprenoid Sesquiterpene (-)-Kumausallene.
abstract: An acyl radical cyclization to form the bicyclic core of (-)-kumausallene (1) was the key feature in the 14-step, enantioselective synthesis. This work demonstrates that the bromoallene unit is robust enough to withstand multiple synthetic operations and provides the unambiguous assignment of the absolute configuration of the bromoallene.
authors.affiliation: Brown Laboratory, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716 (USA).
authors.initials: PA
authors.lastname: Evans
authors.initials: VS
authors.lastname: Murthy
authors.initials: JD
authors.lastname: Roseman
authors.initials: AL
authors.lastname: Rheingold