Congenital myotonic myopathy in the miniature schnauzer: an autosomal recessive trait.
Myotonia is a clinical sign characterized by a delay in skeletal muscle relaxation following electrical or mechanical stimulation. A series of related miniature schnauzer dogs with congenital myotonic myopathy were studied. A composite pedigree of six affected litters and the results of a planned breeding between two affected animals are consistent with an autosomal recessive mode of inheritance.
Vite
C H
CH
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA. vite@vet.upenn.edu
Melniczek
J
J
Patterson
D
D
Giger
U
U
D000818:Animals; D004283:Dog Diseases / Q000151:congenital / Q000235:genetics*; D004285:Dogs; D005260:Female; D008297:Male; D020967:Myotonic Disorders / Q000151:congenital / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree