[Sepsis syndrome and bone marrow granulomatosis after intravesical instillation of BCG].
BACKGROUND
BCG therapy is an effective treatment for superficial bladder carcinoma. Exceptionally, systemic disorders including hypersensitivity reactions or infections may occur.


METHODS
A 70-year-old man developed septicemia with bone marrow granulomatosis with a favorable course after intravesicle administration of bacillus Calmette-Guérin for bladder carcinoma.


CONCLUSIONS
High grade fever, septicemia, hepatitis or pulmonary granulomatosis as well as bone marrow involvement are reported in less than 1% of all cases of BCG therapy. The pathogenic mechanisms are complex. Anti-tuberculous drugs are generally given.
Andrès
E
E
Services de Médecine Interne et Nutrition, Hôpitaux Universitaires de Strasbourg, Hôpital de Hautepierre.
Kuhnert
C
C
Perrin
A E
AE
Averous
G
G
Ruellan
A
A
Goichot
B
B
Schlienger
J L
JL
D000283:Administration, Intravesical; D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D008297:Male; D009163:Mycobacterium bovis; D018805:Sepsis / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000628:therapy*