An antiviral furanoquinone from Paulownia tomentosa Steud.
A methanol extract of the stem bark of Paulownia tomentosa showed antiviral activity against poliovirus types 1 and 3. Sequential liquid-liquid extraction with n-hexane, chloroform and water, and a silicagel column chromatography resulted in the purification of a compound. The compound was identified as methyl-5-hydroxy-dinaphthol[1,2-2',3']furan-7,12-dione-6-carbox yla te on the basis of spectroscopic data. The component caused a significant reduction of viral cytopathic effect when it was subjected to a standard antiviral assay by using HeLa cells. The EC(50) of the compound against poliovirus type 1 strain Brunhilde, and type 3 strain Leon were 0.3 microg/mL and 0.6 microg/mL, respectively.
Kang
K H
KH
College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Huh
H
H
Kim
B K
BK
Lee
C K
CK
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002853:Chromatography, Liquid; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017955:Poliovirus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D013057:Spectrum Analysis; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D005663:Furans; D009281:Naphthalenes; C402369:methyl-5-hydroxy-dinaphthol(1,2-2',3')-furan-7,12-dione-6-carboxylate