Implantation of the undulation pump total artificial heart in the goat.
The undulation pump total artificial heart (UPTAH) was developed by using small-size continuous-flow displacement-type blood pumps (undulation pump). To clarify and improve the problems accompanied by the implantation in the chest, 14 animal experiments were performed on goats weighing 41.3-79.2 kg. The UPTAH could be implanted in the chest of all goats and was driven with a modulation pulsatile mode. The first problem was the atrial suction effect. This problem could be prevented to some extent by developing the soft disk and by improving atrial cuffs. An automatic detection and releasing of the atrial suction effect was also tried. The next problem was acute lung edema accompanied by the postural change of the animal. Development of the automatic control of left atrial pressure could prevent this problem. Small blood leakage from a pinpoint hole in the seal membrane was the next problem. Improvement of the manufacturing procedure of the membrane prevented this. With these improvements, a 10 day survival could be obtained with this unique implantable total artificial heart.
Abe
Y
Y
Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, Japan. abe@bme.rcast.u-tokyo.ac.jp
Chinzei
T
T
Ono
T
T
Mochizuki
S
S
Saito
I
I
Guba
P
P
Karita
T
T
Sun
Y p
Yp
Kouno
A
A
Isoyama
T
T
Baba
K
K
Imachi
K
K
D000208:Acute Disease; D000714:Anastomosis, Surgical; D000818:Animals; D016280:Atrial Function, Right; D001794:Blood Pressure; D005260:Female; D006041:Goats; D006325:Heart Atria; D006354:Heart, Artificial / Q000145:classification; D008422:Materials Testing; D008567:Membranes, Artificial; D011187:Posture; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation; D011654:Pulmonary Edema / Q000209:etiology / Q000517:prevention & control; D011673:Pulsatile Flow; D013499:Surface Properties; D015996:Survival Rate
D008567:Membranes, Artificial