title: Longitudinal melanonychia associated with hydroxyurea therapy in a patient with essential thrombocytosis.
abstract: Occurrence of skin lesions during long-term therapy with hydroxyurea are well described, but there have been only a few case reports of longitudinal melanonychia associated with hydroxyurea treatment. We report herein longitudinal melanonychia associated with hydroxyurea therapy in a subject with essential thrombocytosis. The prolonged time lapse (1 year) between initiation of hydroxyurea therapy and the onset of the longitudinal melanonychia should be noted.
authors.affiliation: Department of Dermatology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: A D
authors.initials: AD
authors.lastname: Cohen
authors.forename: D
authors.initials: D
authors.lastname: Hallel-Halevy
authors.forename: L
authors.initials: L
authors.lastname: Hatskelzon
authors.forename: E
authors.initials: E
authors.lastname: Peretz
authors.forename: S
authors.initials: S
authors.lastname: Halevy
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008543:Melanins / Q000032:analysis; D008548:Melanosis / Q000139:chemically induced*; D009260:Nail Diseases / Q000139:chemically induced*; D013922:Thrombocytosis / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D008543:Melanins; D006918:Hydroxyurea