title: Intraindividual variability in orthostatic blood pressure changes among older adults: the influence of meals.
abstract: OBJECTIVE
  To examine the influence of time of day and of meals on postural blood pressure (BP) changes in older adults.
  
  
  METHODS
  Prevalence study of BP changes in response to orthostasis.
  
  
  METHODS
  A geriatric short-stay department
  
  
  METHODS
  A total of 126 inpatients (91 women and 35 men; mean age: 81.4+/-7.9, range 61-95 years) were included in the study.
  
  
  METHODS
  Two sets of BP and heart rate measurements were obtained for each subject by one examiner using a standard mercury manometer: (1) in mid-morning (between 10:00 and 10:30 a.m.) and (2) within 30 to 60 minutes after lunch (between 1:00 and 1:30 p.m.). Orthostatic hypotension (OH) was defined as a systolic blood pressure (SBP) decline > or = 20 mm Hg within 3 minutes after standing.
  
  
  RESULTS
  Sixty-one participants (48%) experienced significant orthostatic BP decline on at least one reading. Among them, 46 (37%) had OH in the mid-morning, and 32 (25%) had OH after lunch (P = .05). Only 17 (13%) had OH on both readings (persistent OH). Forty-four patients (35%) had variable OH. Patients with persistent OH were more likely to exhibit symptoms of dizziness and had a lower body mass index and a higher mean basal supine SBP. There was a positive correlation between basal supine SBP and postural SBP decline.
  
  
  CONCLUSIONS
  Because of the variability of postural BP changes, the diagnosis of OH should not be based on a single orthostatic BP measurement but requires repeated testing, at best under circumstances similar to those in which the symptoms occurred. The postprandial period is not particularly favorable to OH, suggesting that the ingestion of a meal does not worsen orthostatic BP changes in most aged patients.
authors.affiliation: Department of Geriatrics and Internal Medicine, Centre Hospitalier Régional de Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Puisieux
authors.forename: Y
authors.initials: Y
authors.lastname: Boumbar
authors.forename: H
authors.initials: H
authors.lastname: Bulckaen
authors.forename: E
authors.initials: E
authors.lastname: Bonnin
authors.forename: F
authors.initials: F
authors.lastname: Houssin
authors.forename: P
authors.initials: P
authors.lastname: Dewailly
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D002940:Circadian Rhythm / Q000502:physiology; D004194:Disease; D004244:Dizziness / Q000209:etiology; D004358:Drug Therapy; D004435:Eating / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D015995:Prevalence; D016683:Supine Position / Q000502:physiology