[A recurrent case of esophageal cancer in which metastatic skin tumor disappeared after local injection of activated lymphocytes with tumor-pulsed dendritic cells].
We examined the effect of activated lymphocytes stimulated with tumor-pulsed dendritic cells (DC-K), and found that such stimulation enhanced the cytotoxity of the activated lymphocytes. Furthermore, in applying DC-K to a recurrent case of esophageal cancer, the skin tumors disappeared after local injection of DC-K. The only adverse effect of this treatment was pyrexia. Although no general effect was observed, the local effect was satisfactory. This suggests that DC-K might be useful for local treatment or postoperative adjuvant therapy.
Nagao
N
N
Second Dept. of Surgery, Gifu University School of Medicine.
Katoh
M
M
Kumazawa
I
I
Tomita
H
H
Sugiyama
Y
Y
Kunieda
K
K
Miya
K
K
Saji
S
S
D000368:Aged; D003713:Dendritic Cells / Q000637:transplantation*; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D016219:Immunotherapy, Adoptive; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation; D008297:Male; D012878:Skin Neoplasms / Q000556:secondary* / Q000628:therapy*