Familial adenomatous polyposis: from bedside to bench and vice versa. A tribute to the somatic cell geneticist P. Meera Khan.
Familial adenomatous polyposis (FAP) is characterized by the presence of numerous adenomatous polyps in the colorectum, as well as an autosomal dominant mode of inheritance. This syndrome will inevitably lead to colorectal cancer when left untreated, and it is estimated that 1% of all colorectal cancer cases are due to it. Over the past 20 years molecular genetic studies on FAP patients have laid down the basis for the elucidation of the genetic phenomena that ultimately result in the development of colorectal cancer. Professor P. Meera Khan was one of the leading authorities in the world of molecular genetics of colorectal cancer in general and of FAP in particular. His scientific contributions from the pre-DNA era up to the recent implementation of molecular genetic research in daily clinical practice have helped revolutionize our approach and management of FAP patients and their relatives.
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Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
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D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000235:genetics / Q000266:history* / Q000628:therapy; D025601:Adenomatous Polyposis Coli Protein; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000502:physiology; D017491:Genes, APC; D018740:Genetic Heterogeneity; D005820:Genetic Testing / Q000266:history; D049673:History, 20th Century; D006801:Humans; D007194:India; D009426:Netherlands
D025601:Adenomatous Polyposis Coli Protein; D003598:Cytoskeletal Proteins