[The effect of intra-abdominal temperature on the tissue and tumor diffusion of intraperitoneal cisplatin in a model of peritoneal carcinomatosis in rats].
OBJECTIVE
To evaluate the effects of hyperthermia and hypothermia on the peritoneal and on tumor penetration by intraperitoneal cisplatin.


METHODS
Twenty day old peritoneal carcinomatosis was obtained after intraperitoneal injection of 1 x 10(6) DHD/K12/PROb cells into BD IX rats. Animals were treated by intraperitoneal infusion of cisplatin (25 micrograms/mL) using hyperthermic (16.6 degrees C), normothermic (37.6 degrees C) or hyperthermic (41.8 degrees C) intraperitoneal chemotherapy.


RESULTS
Hyperthermia increased cisplatin concentration in tumoral and diaphragmatic tissues compared to normothermic treatment, while renal concentrations were lower. Hypothermia produced lower cisplatin concentrations in both cancer and peritoneal tissues compared to normothermic treatment.


CONCLUSIONS
These experiments confirmed the pharmacological advantage produced by hyperthermia in cisplatin intraperitoneal chemotherapy.
Benoit
L
L
Unité Inserm 517-mort cellulaire et cancer (Jemenrt 515), faculté de médecine et pharmacie, Dijon, France.
Duvillard
C
C
Rat
P
P
Chauffert
B
B
D000005:Abdomen; D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001831:Body Temperature; D002277:Carcinoma / Q000378:metabolism*; D002945:Cisplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003964:Diaphragm / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006979:Hyperthermia, Induced; D007036:Hypothermia, Induced; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D008297:Male; D010534:Peritoneal Neoplasms / Q000378:metabolism*; D010537:Peritoneum / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D002945:Cisplatin