Single breath exhaled nitric oxide in lung transplant patients: a preliminary clinical study.
Exhaled nitric oxide is considered as a marker of airway inflammation. We report here our preliminary experience with single-breath exhaled nitric oxide measured in lung transplant patients with and without bronchiolitis obliterans syndrome and in cardiac transplant patients. Peak and end-expiratory nitric oxide concentrations did not differ between groups, but single-breath exhaled nitric oxide recordings were strikingly different in patients suffering from bronchiolitis obliterans syndrome, with a slower decrease from peak to end-expiratory nitric oxide concentration. Further studies are required in order to determine whether theses abnormalities reflect the inflammatory process of bronchiolitis obliterans syndrome.
Zegdi
R
R
Service de Chirurgie Thoracique et Cardiovasculaire, Hôpital Broussais, 96 rue Didot, F-75 014 Paris, France. rachidzegdi@post.club-internet.fr
Guillmain
R
R
Amrein
C
C
Chevalier
P
P
Lajos
P
P
Couëtil
J P
JP
Carpentier
A
A
Fabiani
J N
JN
D000328:Adult; D001944:Breath Tests; D001989:Bronchiolitis Obliterans / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D009569:Nitric Oxide / Q000032:analysis*
D009569:Nitric Oxide