title: Induction of CD8+ T cells using heterologous prime-boost immunisation strategies.
abstract: One of the current challenges in vaccine design is the development of antigen delivery systems or vaccination strategies that induce high protective levels of CD8+ T cells. These cells are crucial for protection against certain tumours and intracellular pathogens such as the liver-stage parasite of malaria. A liver-stage malaria vaccine should therefore include CD8+ T-cell-inducing components. This review provides an overview of prime-boost immunisation strategies that result in protective CD8+ T-cell responses against malaria with an emphasis on work from our laboratory. Possible mechanisms explaining why heterologous prime-boost strategies, in particular boosting with replication-impaired recombinant poxviruses, are so effective are discussed.
authors.affiliation: Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, UK. joerg@oxxon.freeserve.co.uk
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: S C
authors.initials: SC
authors.lastname: Gilbert
authors.forename: C M
authors.initials: CM
authors.lastname: Hannan
authors.forename: P
authors.initials: P
authors.lastname: Dégano
authors.forename: E
authors.initials: E
authors.lastname: Prieur
authors.forename: E G
authors.initials: EG
authors.lastname: Sheu
authors.forename: M
authors.initials: M
authors.lastname: Plebanski
authors.forename: A V
authors.initials: AV
authors.lastname: Hill
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000008:administration & dosage; D005822:Genetic Vectors; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D008288:Malaria / Q000276:immunology / Q000517:prevention & control; D017780:Malaria Vaccines / Q000008:administration & dosage; D051379:Mice; D011323:Primates; D019444:Vaccines, DNA / Q000008:administration & dosage
chemical_list: D000276:Adjuvants, Immunologic; D000939:Epitopes; D017780:Malaria Vaccines; D019444:Vaccines, DNA