A study to determine the pharmacokinetics and inflammatory fluid penetration of gatifloxacin following a single oral dose.
A single 400 mg oral dose of gatifloxacin was given to each of nine healthy male volunteers and the concentrations of the drug in plasma, cantharidine-induced inflammatory fluid and urine were measured over the following 24 h. The mean peak concentration in plasma of 4. 1 mg/L was attained at a mean time of 1.8 h post dose. The mean peak concentration in inflammatory fluid was 3.6 mg/L and was attained at a mean time of 4.2 h post dose. The mean plasma elimination half-life of gatifloxacin was 6.8 h and that in inflammatory fluid was 7.2 h. The mean penetration into the inflammatory fluid was 117%. Recovery of drug from urine during the first 24 h post dose was 65% of that administered. Our data suggest that gatifloxacin dosed at 400 mg od should be adequate to treat systemic infections caused by most bacterial species.
Wise
R
R
Department of Medical Microbiology, City Hospital NHS Trust, Birmingham B18 7QH, UK.
Andrews
J M
JM
Ashby
J P
JP
Marshall
J
J
D000284:Administration, Oral; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002193:Cantharidin; D005122:Exudates and Transudates / Q000737:chemistry; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D008297:Male
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002193:Cantharidin; D000077734:Gatifloxacin