Mechanism of enantioselective protonation of an enolate in the presence of a chiral phenolic additive
The synthesis of enantiomerically enriched (+)-(R)-2-methyl-1-tetralone 1 (up to 29% e.e.) was achieved by enantioselective protonation of the achiral enolate such as 2, using the oxazoline (S)-3 as the source of chirality. Copyright 1999 Wiley-Liss, Inc.
Eames
J
Department of Chemistry, Queen Mary and Westfield College, London, United Kingdom.
Weerasooriya
N