title: Cardiopulmonary and sedative effects of intravenous administration of low doses of medetomidine and xylazine to adult horses.
abstract: OBJECTIVE
  To determine the cardiopulmonary and sedative effects of medetomidine hydrochloride in adult horses and to compare those effects with effects of an equipotent dose of xylazine hydrochloride.
  
  
  METHODS
  10 healthy adult female horses.
  
  
  METHODS
  5 horses were given medetomidine (4 microg/kg of body weight, i.v.), and the other 5 were given xylazine (0.4 mg/kg, i.v.). Heart rate, respiratory rate, arterial blood pressures, pulmonary arterial blood pressures, and cardiac output were recorded, and sedation and ataxia scores were assigned before and every 5 minutes after drug administration for 60 minutes. Rectal temperature and blood gas partial pressures were measured every 15 minutes after drug administration.
  
  
  RESULTS
  Arterial blood pressure was significantly decreased throughout the study among horses given medetomidine and was significantly decreased for 40 minutes among horses given xylazine. Compared with baseline values, cardiac output was significantly decreased 10, 20, and 40 minutes after administration of medetomidine and significantly increased 40 and 60 minutes after administration of xylazine. Despite the significant decrease in respiratory rate in both groups, results of blood gas analyses were not significantly changed over time. Ataxia and sedation scores were of similar magnitude for the 2 groups, but ataxia persisted slightly longer among horses given medetomidine. Horses resumed eating hay 10 to 55 minutes after drug administration.
  
  
  CONCLUSIONS
  Results suggest that equipotent low doses of medetomidine and xylazine induce comparable levels of ataxia and sedation and similar cardiopulmonary changes in adult horses.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Bueno
authors.forename: J
authors.initials: J
authors.lastname: Cornick-Seahorn
authors.forename: T L
authors.initials: TL
authors.lastname: Seahorn
authors.forename: G
authors.initials: G
authors.lastname: Hosgood
authors.forename: R M
authors.initials: RM
authors.lastname: Moore
mesh_terms: D000818:Animals; D001259:Ataxia / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006736:Horses; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D020926:Medetomidine / Q000008:administration & dosage / Q000494:pharmacology*; D011651:Pulmonary Artery / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004731:Endotoxins; D006993:Hypnotics and Sedatives; D014991:Xylazine; D020926:Medetomidine