[Reversible aggregation and the surface architectonics of the peripheral blood erythrocytes in lung cancer patients before and during the carrying out of antitumor polychemotherapy].
In study of the parameters characterizing the minimal--U0(B) and maximal--UD(B) mechanical stability of aggregates, half period of red cell spontaneous aggregation--tau (in mm), photometric signal amplitude characterizing the number of red cells taking part in aggregation--A (in mm), and in calculating the aggregation index 1a and the integral coefficient of aggregation K intensification of reversible aggregation of the peripheral red blood cells was revealed in patients with lung cancer, which grew against the background of increase in the number of modified red blood cells during application of antitumor polychemotherapy.
Novitskiĭ
V V
VV
Institute of Pharmacology, Tomsk Research Center, Siberian Branch, Russian Academy of Medical Sciences, Russia.
Stepovaia
E A
EA
Gol'dberg
V E
VE
Kolosova
M V
MV
Koreshkova
K G
KG
Sokolova
I B
IB
Bulavina
Ia V
IaV
D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013499:Surface Properties
D000964:Antimetabolites, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D004317:Doxorubicin; D003520:Cyclophosphamide; D008727:Methotrexate