title: Diabetes mellitus: biological determinants of atherosclerosis and restenosis.
abstract: Diabetes mellitus is a potent risk factor for the development of atherosclerosis. Patients with diabetes account for approximately 20% of patients presenting with acute coronary syndromes or for percutaneous coronary intervention. Furthermore, the incidence of diabetes continues to increase world-wide, such that substantial medical resources are allocated for the care of patients with diabetic cardiovascular complications. Although great strides have been made in reducing cardiovascular events in recent years, there has been little improvement in outcomes for patients with diabetes mellitus. This review will focus in the underlying patho-biology and the current status of therapeutic interventional strategies for patients with diabetes mellitus.
authors.affiliation: Department of Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. marsos@msn.com
authors.forename: S P
authors.initials: SP
authors.lastname: Marso
authors.forename: K H
authors.initials: KH
authors.lastname: Mak
authors.forename: E J
authors.initials: EJ
authors.lastname: Topol
mesh_terms: D001685:Biological Factors / Q000097:blood*; D001786:Blood Glucose; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment
chemical_list: D001685:Biological Factors; D001786:Blood Glucose