title: Cyclodextrin-based optosensor for the determination of warfarin in waters.
abstract: A flow-through optosensor for warfarin is described. The sensor is developed in conjunction with flow analysis systems and uses a commercial bound beta-cyclodextrin material as the sensing phase. A strong fluorescence signal was observed as a result of the formation of an inclusion complex between warfarin and beta-cyclodextrin. The analytical performance characteristics of the proposed sensor for analysis of low levels of warfarin were as follows: the detection limits for continuous and flow injection analysis systems were 2 and 19 ppb, respectively; the observed relative standard deviations at 0. 5 ppm warfarin level were less than 2.3%. A study of the interference of other naphthalenic toxic substances was carried out. The continuous flow method was satisfactorily applied to the determination of the rodenticide in natural waters.
authors.affiliation: Department of Physical Chemistry, Faculty of Chemistry, University of Oviedo, c/Julián Clavería 8, 33006 Oviedo, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Badía
authors.forename: M E
authors.initials: ME
authors.lastname: Díaz-García
mesh_terms: D000383:Agriculture / Q000379:methods; D000818:Animals; D003505:Cyclodextrins; D006801:Humans; D051381:Rats; D012378:Rodenticides / Q000032:analysis*; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation*; D014859:Warfarin / Q000032:analysis*; D014867:Water / Q000737:chemistry*; D014877:Water Pollution, Chemical / Q000032:analysis*
chemical_list: D003505:Cyclodextrins; D012378:Rodenticides; D014867:Water; D014859:Warfarin