title: Progestin regulation in tumor growth of female genital tract cancers.
abstract: The irregular response to progestins directly in tumor growth might be caused by dominant negative progesterone receptor (PR) mutants and the damage to PR-A expression. Progestin treatment as an anti-angiogenic therapy would be less effective in the PR-mutated tumors. Therefore, various anti-angiogenic inhibitors must be used in progestin-refractory and progestin-dependent tumors.
authors.affiliation: Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Fujimoto
authors.forename: H
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: R
authors.initials: R
authors.lastname: Misao
authors.forename: R
authors.initials: R
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Wen
authors.forename: T
authors.initials: T
authors.lastname: Tamaya
mesh_terms: D016228:Endothelial Growth Factors / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005833:Genital Neoplasms, Female / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008222:Lymphokines / Q000378:metabolism; D009154:Mutation; D009376:Neoplasms, Hormone-Dependent / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011372:Progestins / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D011372:Progestins; D020033:Protein Isoforms; D011980:Receptors, Progesterone; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2; D013939:Thymidine Phosphorylase