Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus.
Molluscum contagiosum virus (MCV) encodes a CC chemokine MC148R which is likely to have been acquired from the host. By a homology search employing MC148R as a probe, we have identified a novel CC chemokine whose gene exists next to the IL-11 receptor alpha (IL-11Ralpha) gene in both humans and mice. Thus, this chemokine maps to chromosome 9p13 in humans where IL-11Ralpha has been assigned. We term this novel chemokine IL-11Ralpha-locus chemokine (ILC). ILC has the highest homology to MC148R among the known human CC chemokines. Furthermore, ILC is strongly and selectively expressed in the skin where infection of MCV also takes place. Thus, ILC is likely to be the original chemokine of MC148R.
Ishikawa-Mochizuki
I
I
Shionogi Institute for Medical Science, Osaka, Japan.
Kitaura
M
M
Baba
M
M
Nakayama
T
T
Izawa
D
D
Imai
T
T
Yamada
H
H
Hieshima
K
K
Suzuki
R
R
Nomiyama
H
H
Yoshie
O
O
D000595:Amino Acid Sequence; D000818:Animals; D054425:Chemokine CCL27; D019742:Chemokines, CC / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000302:isolation & purification; D006801:Humans; D017370:Interleukin-11 / Q000378:metabolism*; D053703:Interleukin-11 Receptor alpha Subunit; D051379:Mice; D008969:Molecular Sequence Data; D008977:Molluscum contagiosum virus / Q000235:genetics*; D009928:Organ Specificity / Q000235:genetics; D018123:Receptors, Interleukin / Q000378:metabolism*; D053702:Receptors, Interleukin-11; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics*
C492276:CCL27 protein, human; C119538:Ccl27a protein, mouse; D054425:Chemokine CCL27; D019742:Chemokines, CC; D018076:DNA, Complementary; C508428:IL11RA protein, human; C508429:Il11ra1 protein, mouse; C508431:Il11ra2 protein, mouse; D017370:Interleukin-11; D053703:Interleukin-11 Receptor alpha Subunit; D018123:Receptors, Interleukin; D053702:Receptors, Interleukin-11; D011994:Recombinant Proteins; D014764:Viral Proteins