title: Dietary NaC1 during pregnancy and lactation: effect on brain angiotensin II receptors and behavior.
abstract: Female rats were fed diets containing either a basal (0.12%), mid- (1%) or high (3%) level of NaCl during pregnancy and lactation. Plasma aldosterone was elevated approximately 5- and 15-fold in dams fed basal compared with either the mid- or high-NaCl diets at the end of both pregnancy and lactation (Postnatal Day 21), respectively. Dams fed basal diet and killed at the end of lactation had a higher density of angiotensin II receptors in the organum vasculosum laminae terminalis, paraventricular hypothalamus, and median preoptic nucleus than did rats fed either mid- or high-NaCl diets. Other dams, treated identically, were returned to rodent chow (approximately 0.2% NaCl) at the end of lactation for intake tests during the next week. Dams that had received basal diet did not differ from mid-NaCl and high-NaCl groups in sodium appetite induced by either acute sodium depletion or mineralocorticoid administration but showed the lowest spontaneous intake of NaCl solution.
authors.affiliation: Department of Psychology, University of Florida, Gainesville 32611-2250, USA. rowland@psych.ufl.edu
authors.forename: N E
authors.initials: NE
authors.lastname: Rowland
authors.forename: E C
authors.initials: EC
authors.lastname: Crews
authors.forename: S L
authors.initials: SL
authors.lastname: Young
authors.forename: R C
authors.initials: RC
authors.lastname: Speth
mesh_terms: D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D005260:Female; D007774:Lactation / Q000097:blood* / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011945:Receptors, Angiotensin / Q000187:drug effects*; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: D011945:Receptors, Angiotensin; D017673:Sodium Chloride, Dietary; D000450:Aldosterone; D011374:Progesterone; D003345:Corticosterone