Monoamine oxidase inhibitory naphthoquinone and/or naphthalene dimers from Lemuni Hitam (Diospyros sp.), a Malaysian herbal medicine.
From the extract of a Malaysian herbal medicine, Lemuni Hitam (Diospyros sp.), which exhibited monoamine oxidase (MAO) inhibition, three new naphthoquinone and/or naphthalene dimers (lemuninols A-C, 1-3) were isolated together with 4,6-dihydroxy-5-methoxy-2-methyl-naphthalene (8) and six known monomers (4-7, 9 and 10). The structures were determined by spectroscopic methods including 2D-NMR techniques. Among them, lemuninol A showed 45% inhibition of MAO (mouse liver) at 5.0 x 10(-6) g/ml, and lemuninols B and C and a naphthoquinone (9) indicated weak activity. Some related quinones were also tested for their MAO inhibitory activities.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Homma
M
M
Satoh
Y
Y
Fujimoto
H
H
Ishibashi
M
M
Yamazaki
M
M
Satake
M
M
Ghazali
A B
AB
D000818:Animals; D019281:Dimerization; D008297:Male; D051379:Mice; D008956:Models, Chemical; D008996:Monoamine Oxidase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D008996:Monoamine Oxidase Inhibitors; D009281:Naphthalenes; D009285:Naphthoquinones; D010936:Plant Extracts; C031721:naphthalene