title: Advancement in the zone of calcified cartilage in osteoarthritic hands of patients detected by high definition macroradiography.
abstract: OBJECTIVE
  High definition macroradiography permits the advancement in the zone of calcified cartilage (described as a ZCC step) to be detected in osteoarthritic (OA) hand joints of patients. The pattern of their incidence and distribution was determined and compared to the joint space width (JSW) measurement.
  
  
  METHODS
  Macroradiographs, x5 magnification, were obtained of the OA hands of 44 patients at baseline and at 18 months. The incidence of ZCC steps, identified as an advancement in the mineralized cartilage front into articular cartilage, was assessed at each articular surface. JSW was measured and was used to determine the difference in JSW between hands and groups of joints with and without ZCC steps at both X-ray visits.
  
  
  RESULTS
  ZCC steps were only found at the convex articular surfaces in 42 (48%) of hand joints in 28 (64%) patients. Here, ZCC steps were present in 36 joints in the non-dominant hand compared to 30 joints in the dominant hand. In the former, they were present in 22 DIP, six PIP and eight MCP joints and in 12 DIP, 8 PIP and 10 MCP joints in the dominant hand. By 18 months new ZCC steps had formed in 15 hands with and 17 hands without previous ZCC steps. At both X-ray visits no statistically significant difference in JSW was found between the hands and joint groups with and without ZCC steps.
  
  
  CONCLUSIONS
  Although ZCC steps and JSW loss were greater at the PIP joints, supporting a mechanical hypothesis for ZCC formation, their presence in joints, where JSW was larger, and their greater incidence in the non-dominant PIP joints, suggest that factors associated with vascular changes, related to subchondral bone remodeling, are responsible.¿copy¿
authors.affiliation: Department of Applied Clinical Anatomy, Division of Anatomy, Human and Cell Biology, Guy's, King's & St Thomas School of Biomedical Science, King's College London, Guy's Hospital Campus, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Patel
authors.forename: C
authors.initials: C
authors.lastname: Buckland-Wright
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000209:etiology; D002357:Cartilage Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications / Q000000981:diagnostic imaging*; D011859:Radiography