Gastroprotection by Liu-Jun-Zi-Tang (TJ-43): possible mediation of nitric oxide but not prostaglandins or sulfhydryls.
Liu-Jun-Zi-Tang (TJ-43), a herbal medicine exerting gastroprotective action, was examined for its mechanism of action in rats. TJ-43 significantly inhibited gastric mucosal damage caused by absolute ethanol at doses over 500 mg/kg in a dose-dependent way. Pretreatment with indomethacin or with N-ethylmaleimide did not affect the gastroprotective effect of TJ-43. However, pretreatment with NG-nitro-L-arginine partially but significantly reversed the protective effect of this drug. These findings suggest that the gastroprotective effect of TJ-43 occurs partly through nitric oxide but not through prostaglandins or sulfhydryls.
Arakawa
T
T
Third Department of Internal Medicine, Osaka City University Medical School, Japan. arakawat@med.osaka-cu.ac.jp
Higuchi
K
K
Fujiwara
Y
Y
Watanabe
T
T
Tominaga
K
K
Hayakawa
T
T
Kuroki
T
T
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity; D005033:Ethylmaleimide / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013439:Sulfhydryl Reagents / Q000494:pharmacology
D016861:Cyclooxygenase Inhibitors; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D011453:Prostaglandins; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; C084136:liu-jun-zi-tang; D019335:Nitroarginine; D009569:Nitric Oxide; D000431:Ethanol; D019001:Nitric Oxide Synthase; D005033:Ethylmaleimide; D007213:Indomethacin