title: Cardiac troponin T release during coronary surgery using intermittent cross-clamp with fibrillation, on-pump and off-pump beating heart.
abstract: OBJECTIVE
  Troponin T is a unique marker which might be particularly useful in assessing myocardial cell damage in patients undergoing cardiac surgery. The aim of the study was a comparison between intra-operative release of troponin T (TnT) during three different myocardial protection strategies.
  
  
  METHODS
  Thirty-eight PTS undergoing myocardial revascularization were randomised into 3 groups in whom procedure was performed with intermittent cross-clamp (Group I; n = 13), beating-heart on pump without aortic cross-clamp (Group II; n = 12), beating-heart without use of extracorporeal circulation (Group III; n = 13). Serial venous blood samples were collected for TnT measurement prior surgery, 1, 4, 12, 24, 48, 72 h after the procedure. Haemodynamic measurements were made using a thermodilution PA catheter.
  
  
  RESULTS
  The groups were similar with respect to age, sex, preoperative LV function, number of grafts, potential risk factors. There were no hospital deaths and no myocardial infarction (MI) in three groups, postoperative haemodynamic measurements showed no significant differences. TnT serum levels were significantly higher in group I when compared to groups II and III. TnT levels were significantly lower in group Ill when compared to group II following 48-h post-operation.
  
  
  CONCLUSIONS
  Coronary bypass grafting without aortic cross-clamping and without CPB offers superior myocardial protection.
authors.affiliation: 1st Cardiac Surgery Department, Silesian Heart Center, Katowice, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Krejca
authors.forename: J
authors.initials: J
authors.lastname: Skiba
authors.forename: P
authors.initials: P
authors.lastname: Szmagala
authors.forename: T
authors.initials: T
authors.lastname: Gburek
authors.forename: A
authors.initials: A
authors.lastname: Bochenek
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D003250:Constriction; D001026:Coronary Artery Bypass / Q000379:methods*; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D006321:Heart / Q000502:physiology; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000517:prevention & control*; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D020107:Troponin T