title: Regulating the activity of a cardioacceleratory peptide.
abstract: We measured the effect of crustacean cardioactive peptide on Drosophila heart rate in the animal and in a tissue preparation. Crustacean cardioactive peptide increased in vivo basal heart rate 1%, 6%, and 19% and increased in vitro basal heart rate 52%, 25%, and 35% in larvae, pupae, and adults, respectively. In the tissue preparation, the acceleratory period was followed by decreased in vitro heart rates of 42%, 16%, and 13% in larvae, pupae, and adults, respectively. The effects observed in the animal and tissue and in larvae, pupae, and adults suggest that Drosophila crustacean cardioactive peptide cardiac signaling is modulated and developmentally regulated.
authors.affiliation: Department of Biological Chemistry, University of Michigan, Ann Arbor 48109-1048, USA. nicholsr@umich.edu
authors.forename: R
authors.initials: R
authors.lastname: Nichols
authors.forename: S
authors.initials: S
authors.lastname: Kaminski
authors.forename: E
authors.initials: E
authors.lastname: Walling
authors.forename: E
authors.initials: E
authors.lastname: Zornik
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology*; D007814:Larva; D009479:Neuropeptides / Q000502:physiology*; D011679:Pupa
chemical_list: D009479:Neuropeptides; C058620:crustacean cardioactive peptide