title: Development of short latency vestibular evoked potentials in the neonatal rat.
abstract: The development of short latency vestibular evoked potentials (VsEPs) was investigated in the neonatal rat. Using the appropriate stimulus (linear or angular acceleration impulses) and head orientation, responses elicited in various vestibular end-organs (utricle: x-VsEP; saccule: z-VsEP; lateral semi-circular canal: a-VsEP) were measured in rat pups at various ages between post-natal days (PND) 5 and 30, and compared to those recorded from adult animals. It was found that the VsEPs initially appeared on PND 6 (x-VsEPs and z-VsEPs) or 7 (a-VsEPs), and that by PND 8 the three responses could be recorded in all animals. The first wave of the responses, generated in the primary sensory nerve and reflecting end-organ activity, reached adult latencies and amplitudes by PND 10, showing rapid maturity of the responses. Auditory responses, on the other hand, develop at a later stage (from PND 11). The possible mechanisms involved in this differential maturation between vestibular and auditory activity are discussed.
authors.affiliation: Dept. of Physiology, Hebrew University-Hadassah Medical School, POB 12272, Jerusalem, Israel. freeman@pob.huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Freeman
authors.forename: M
authors.initials: M
authors.lastname: Plotnik
authors.forename: J
authors.initials: J
authors.lastname: Elidan
authors.forename: H
authors.initials: H
authors.lastname: Sohmer
mesh_terms: D000054:Acceleration; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D005072:Evoked Potentials, Auditory; D016057:Evoked Potentials, Auditory, Brain Stem; D051381:Rats; D014722:Vestibule, Labyrinth / Q000254:growth & development / Q000294:innervation / Q000502:physiology*