Viral infections in interferon-gamma receptor deficiency.
Interferon-gamma receptor deficiency is a recently described immunodeficiency that is associated with onset of severe mycobacterial infections in childhood. We describe the occurrence of symptomatic and often severe viral infections in 4 patients with interferon-gamma receptor deficiency and mycobacterial disease. The viral pathogens included herpes viruses, parainfluenza virus type 3, and respiratory syncytial virus. We conclude that patients with interferon-gamma receptor deficiency and mycobacterial disease have increased susceptibility to some viral pathogens.
Dorman
S E
SE
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Department of Pathology, National Institutes of Health, Bethesda, Maryland 20892, USA.
Uzel
G
G
Roesler
J
J
Bradley
J S
JS
Bastian
J
J
Billman
G
G
King
S
S
Filie
A
A
Schermerhorn
J
J
Holland
S M
SM
D015703:Antigens, CD / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology; D007223:Infant; D008297:Male; D009164:Mycobacterium Infections / Q000276:immunology*; D010641:Phenotype; D017471:Receptors, Interferon / Q000172:deficiency* / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D000096743:Interferon gamma Receptor
D015703:Antigens, CD; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor