Cataract induced by short-term administration of large doses of busulfan: a case report.
Busulfan is a carcinostatic which is used for myelocytic leukemia. A 42-year-old Japanese woman given high doses of busulfan for a short time was referred to us because of decreased visual acuity and blurred vision in both eyes. She received 212 mg/day of busulfan for only 4 days. Ophthalmoscopic examination demonstrated a posterior polar subcapsular opacity of the lens in both eyes. Although the occurrence of cataract due to busulfan has been reported after long-term administration of busulfan, this is the first clinical case of cataract caused by high doses of busulfan for a short period. It is necessary to pay more attention to busulfan cataract.
Kaida
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Department of Ophthalmology, Nagasaki University, School of Medicine, Nagasaki, Japan.
Ogawa
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Amemiya
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D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D002066:Busulfan / Q000009:adverse effects*; D002386:Cataract / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D013997:Time Factors; D014792:Visual Acuity / Q000187:drug effects
D018906:Antineoplastic Agents, Alkylating; D002066:Busulfan