title: Thyroid testing and thyroid hormone replacement in patients with sleep disordered breathing.
abstract: The current literature recommends that patients who have symptoms of sleep disordered breathing should be evaluated for hypothyroidism. Thyroid hormone replacement therapy has been reported by some authors to be effective in treating obstructive sleep apnea in hypothyroid patients. The present study prospectively evaluated the prevalence of hypothyroidism in 1,000 consecutively presenting patients who came to the office for evaluation of snoring or obstructive sleep apnea syndrome. The authors also examined the efficacy of treatment for hypothyroidism on sleep apnea in patients with both disorders. Of the 1,000 patients, routine thyroid testing was performed on 834; only 10 of these patients (1.2%) were discovered to have previously undiagnosed clinical hypothyroidism. Four of the 10 patients with newly diagnosed clinical hypothyroidism had obstructive sleep apnea syndrome, and they received thyroid hormone replacement therapy. Once these four patients achieved a euthyroid state, repeat polysomnography showed that there was no significant difference between their pre- and posttreatment respiratory disturbance index. Based on the results of our study, we conclude the following: 1) The prevalence of hypothyroidism in patients who are evaluated for sleep disordered breathing is no greater than that of the general population. 2) Thyroid replacement therapy results in little or no improvement in sleep apnea in patients with clinical hypothyroidism. 3) Routine thyroid function screening is not indicated for patients who are being evaluated for sleep disordered breathing.
authors.affiliation: Atlanta Ear, Nose, and Throat Associates, Washington University School of Medicine, St. Louis, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Mickelson
authors.forename: T
authors.initials: T
authors.lastname: Lian
authors.forename: L
authors.initials: L
authors.lastname: Rosenthal
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000209:etiology; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013963:Thyroid Hormones