[The anti-ischemic effects of 3-hydroxypyridine derivatives in cerebrovascular pathology].
The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.
Pogorelyĭ
V E
VE
Department of Pharmacology, Pyatigorsk State Pharmaceutical Academy, Russia.
Arl't
A V
AV
Gaevyĭ
M D
MD
Gatsura
V V
VV
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D013997:Time Factors
D000975:Antioxidants; C401342:LBK 10; C401343:LBK 38; D010847:Picolines; D011725:Pyridines; C070020:emoxypine succinate; C023500:3-hydroxypyridine