Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro.
A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol.
Larget
R
R
Laboratoire de Chimie Analytique et Electrochimie, UMR 8638 CNRS-Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
Lockhart
B
B
Pfeiffer
B
B
Neudorffer
A
A
Fleury
M B
MB
Largeron
M
M
D000627:Aminophenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D006624:Hippocampus / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
D000627:Aminophenols; D000975:Antioxidants; D018696:Neuroprotective Agents; D014810:Vitamin E