title: Disseminated aspergillosis involving the brain: distribution and imaging characteristics.
abstract: OBJECTIVE
  Systemic invasive aspergillosis involves the brain through hematogenous dissemination. A retrospective review of 18 patients with aspergillosis involving the brain was performed in order to present imaging findings and thereby broaden the understanding of the distribution and imaging characteristics of brain Aspergillus infection and to facilitate its early diagnosis.
  
  
  METHODS
  The neuroimaging studies of 17 biopsy- or autopsy-proved cases and one clinically diagnosed case were examined retrospectively by two neuroradiologists. The studies were evaluated for anatomic distribution of lesions, signal characteristics of lesions, enhancement, hemorrhage, and progression on serial studies (when performed). Medical records, biopsy reports, and autopsy findings were reviewed.
  
  
  RESULTS
  Thirteen of 18 patients had involvement of the basal nuclei and/or thalami. Nine of the 10 patients with lesions at the corticomedullary junction also had lesions in the basal nuclei or thalami. Callosal lesions were seen in seven patients. Progression of lesion number and size was seen in all 11 patients in whom serial studies had been performed. Enhancement was minimal or absent in most cases. There was gross hemorrhage in eight of the 18, and definite ring-enhancement in three.
  
  
  CONCLUSIONS
  Among our cases, lesions in perforating artery territories were more common than those at the corticomedullary junction. Ring enhancement and gross hemorrhage may be present, but are not necessary for the prospective diagnosis.
authors.affiliation: Department of Radiology, University of Wisconsin Hospital and Clinics, Madison 53792, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: DeLone
authors.forename: R A
authors.initials: RA
authors.lastname: Goldstein
authors.forename: G
authors.initials: G
authors.lastname: Petermann
authors.forename: M S
authors.initials: MS
authors.lastname: Salamat
authors.forename: J M
authors.initials: JM
authors.lastname: Miles
authors.forename: S J
authors.initials: SJ
authors.lastname: Knechtle
authors.forename: W D
authors.initials: WD
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D001922:Brain Abscess / Q000175:diagnosis / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020953:Neuroaspergillosis / Q000175:diagnosis* / Q000473:pathology; D009894:Opportunistic Infections / Q000175:diagnosis / Q000473:pathology