title: Intracranial neoplasms in the first year of life: results of a second cohort of patients from a single institution.
abstract: The objective of this study was to describe the presentation and outcome of children with intracranial tumours under 1 year of age, and to compare the results with a previous cohort from the same paediatric neurosurgical unit. It is a retrospective review of all children under 1 year of age presenting with intracranial tumours between 1982 and 1997, with follow-up data from a multidisciplinary paediatric neuro-oncology clinic. Seventy-five children were diagnosed during the period of study. Overall survival at 5 years was 56% (31 of 55 eligible children), half of whom are in mainstream education. Earlier diagnosis and a dramatic reduction in peri-operative mortality compared to our previous cohort account for the improvements in the results of treatment for these children whose care can only be properly managed in a specialized paediatric oncology centre.
authors.affiliation: Department of Neurosurgery, Great Ormond Street Hospital for Children NHS Trust, London, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kane
authors.forename: K P
authors.initials: KP
authors.lastname: Phipps
authors.forename: W F
authors.initials: WF
authors.lastname: Harkness
authors.forename: R D
authors.initials: RD
authors.lastname: Hayward
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D010348:Patient Care Team; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome