title: Aeration affects acetate destination in Gibberella fujikuroi.
abstract: Gibberellins, fatty acids and the polyketides bikaverin and fusarin C are synthesized from a common precursor, acetyl-CoA. The production of these compounds in Gibberella fujikuroi was strongly influenced by aeration, determined by the air/medium ratio in shaken batch cultures. Higher aeration resulted in increased growth and the production of bikaverin and gibberellins. Low aeration stimulated fatty acid and fusarin C production. Feeding experiments with labeled leucine or acetate resulted in different proportions of labeled palmitic acid and bikaverin, indicating that these compounds are synthesized from independent acetate pools.
authors.affiliation: Departamento de Biología Molecular, Universidad Nacional de Río Cuarto, 5800, Río Cuarto, Argentina.
authors.forename: W
authors.initials: W
authors.lastname: Giordano
authors.forename: C E
authors.initials: CE
authors.lastname: Domenech
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000388:Air; D005227:Fatty Acids / Q000378:metabolism; D005874:Gibberella / Q000254:growth & development / Q000378:metabolism*; D005875:Gibberellins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007930:Leucine / Q000378:metabolism; D011090:Polyenes / Q000378:metabolism; D014966:Xanthenes / Q000378:metabolism; D044004:Xanthones
chemical_list: D000085:Acetates; D005227:Fatty Acids; D005875:Gibberellins; D011090:Polyenes; D014966:Xanthenes; D044004:Xanthones; C000269:bikaverin; C041403:fusarin C; D007930:Leucine