Mucocutaneous manifestations of HIV infection in 91 children born to HIV-seropositive women.
We examined 91 children under the age of 13 years with definite HIV infection born to HIV-seropositive women. The clinical spectrum of HIV infection in children younger than 13 years who are born to HIV-infected mothers was revised in 1994 into four clinical categories: category N (not symptomatic), category A (mildly symptomatic), category B (moderately symptomatic), and category C (severely symptomatic). Mucocutaneous manifestations were found in 47 (51.6%) of these children. The prevalence of mucocutaneous manifestations in categories A, B, and C were 4%, 62%, and 75%, respectively. The mucocutaneous manifestations in patients in categories B and C were significantly more common than in those category A (p < 0.001). The most common finding was oral candidiasis (36.3%). Drug rash, pruritic papular eruption, herpes zoster, cutaneous candidiasis, Penicillium marneffei infection, and herpes simplex virus stomatitis were found in 6.6%, 5.5%, 4. 4%, 3.4%, and 2. 2% of patients, respectively. All three patients who had disseminated P. marneffei infection were in category C.
Wananukul
S
S
Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
Thisyakorn
U
U
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000635:transmission*; D006679:HIV Seropositivity / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D015995:Prevalence; D018570:Risk Assessment; D017678:Sex Distribution; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology*; D012874:Skin Diseases, Infectious / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D013785:Thailand / Q000453:epidemiology