Behavior of blood vessels during lower-leg lengthening using the Ilizarov method.
Using a ring fixator, lengthening of the right lower leg by 2.5 cm at a distraction rate of 2 x 0.5 mm per day was performed in 24 beagle dogs. After a postoperative latency period of 5 days and a distraction phase of 25 days, half the dogs were killed (30-day group). The remaining half were killed after a second interval of 25 days (55-day group). After the experiment, the anterior tibialis artery and vein with their supporting vessels, as well as the lesser saphenous vein of both the lengthened right side and the control side were excised and examined histologically, histomorphometrically, and electron microcopically. No morphologic changes of the vascular walls and no increase of collagenous or elastic fibers could be found. The histomorphometric evaluations showed a significant increase in the number of vasa vasorum in the dogs of both the 30- and 55-day groups. No significant difference in thickness of the vascular wall, tunica media, and adventitia could be observed between the lengthened and the control side in both dog groups. It seems that blood vessels can adapt to continuous tension during callus distraction without suffering structural damage and are the least limiting factor concerning distraction speed, distraction rhythm, and distraction length during callus distraction.
Fink
B
B
Laboratory Animal Research Institute and the Institute for Pathology of the Heinrich-Heine-University, Düsseldorf, Germany.
Singer
J
J
Braunstein
S
S
Schwinger
G
G
Schmielau
G
G
Rüther
W
W
D000818:Animals; D001852:Bone Lengthening / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D018889:Ilizarov Technique; D007150:Immunohistochemistry; D008297:Male; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D018709:Statistics, Nonparametric; D013977:Tibia / Q000098:blood supply* / Q000601:surgery*; D016909:Tibial Arteries / Q000473:pathology* / Q000502:physiology; D014654:Vascular Patency