title: A large-scale evaluation of terminology integration characteristics.
abstract: OBJECTIVE
  To describe terminology integration characteristics of local specialty specific and general vocabularies in order to facilitate the appropriate inclusion and mapping of these terms into a large-scale terminology.
  
  
  METHODS
  We compared the sensitivity, specificity, positive predictive value, and positive likelihood ratios for Automated Term Composition to correctly map 9050 local specialty specific (dermatology) terms and 4994 local general terms to UMLS using Metaphrase. Results were systematically combined among exact matches, semantic type filtered matches, and non-filtered matches. For the general set, an analysis of semantic type filtering was performed.
  
  
  RESULTS
  Dermatology exact matches defined a sensitivity of 51% (57% for general terms) and a specificity of 86% (92% general terms). Including semantic type filtered matches increased sensitivity (75% dermatology; 88% general); as did inclusion of non-filtered matches (98% and 99%). These inclusions correspondingly decreased specificity (filtered: 82% and 74%; non-filtered: 52% and 32%). Positive predictive values for exact matches (93.0% dermatology, 97.6% general) were improved by small but significant (p < 0.001) margins by including filtered matches (95.1% dermatology, 98.4% general) but decreased with non-filtered matches (89.2% dermatology, 87.8% general). Adding additional semantic types to the filtering algorithm failed to improve the positive predictive value or the positive likelihood ratio of term mapping, in spite of a 2.3% improvement in sensitivity.
  
  
  CONCLUSIONS
  Automated methods for mapping local "colloquial" terminologies to large-scale controlled health vocabulary systems are practical (ppv 95% dermatology, 98% general). Semantic type filtering improves specificity without sacrificing sensitivity and yields high positive predictive values in every set analyzed.
authors.affiliation: Mayo Foundation, Rochester, MN, USA.
authors.forename: F S
authors.initials: FS
authors.lastname: McDonald
authors.forename: C G
authors.initials: CG
authors.lastname: Chute
authors.forename: P V
authors.initials: PV
authors.lastname: Ogren
authors.forename: D
authors.initials: D
authors.lastname: Wahner-Roedler
authors.forename: P L
authors.initials: PL
authors.lastname: Elkin
mesh_terms: D000465:Algorithms; D003880:Dermatology / Q000145:classification*; D001330:Electronic Data Processing; D006801:Humans; D013358:Subject Headings; D009626:Terminology as Topic; D018875:Vocabulary, Controlled