title: Stabilization of azadirachtin A in neem formulations: effect of some solid carriers, neem oil, and stabilizers.
abstract: Formulation of azadirachtin A on attapulgite, kaolinite, fuller's earth, hydrated calcium silicate, and fly ash revealed that it degraded to the tune of 70-95% on different solid carriers as compared to 56% in neem oil, during the 14 day heat storage studies at 54 +/- 1 degrees C in the laboratory. The degradation was reduced by 26-60% on different carriers by employing either anthraquinone or epichlorohydrin as stabilizer. Pyrogallol and hydroquinone enhanced the degradation. The cation exchange capacity and surface area of the carriers revealed a significant negative correlation with t(1/2) of azadirachtin A.
authors.affiliation: Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi, India.
authors.forename: J
authors.initials: J
authors.lastname: Kumar
authors.forename: B S
authors.initials: BS
authors.lastname: Parmar
mesh_terms: D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004355:Drug Stability; D005079:Excipients; D005989:Glycerides; D007306:Insecticides / Q000737:chemistry*; D036701:Limonins; D010938:Plant Oils; D013729:Terpenes; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D005079:Excipients; D005989:Glycerides; D007306:Insecticides; D036701:Limonins; D010938:Plant Oils; D013729:Terpenes; D014315:Triterpenes; C002443:neem oil; C010329:azadirachtin