title: Torsion of a functional ovarian cyst in a premenopausal patient receiving tamoxifen.
abstract: We report a case of torsion of an ovarian follicular cyst that developed during treatment with tamoxifen for breast cancer. A 40-year-old Japanese woman was admitted complaining of acute lower abdominal pain. Eight months earlier, she had undergone a partial mastectomy and local irradiation for ductal carcinoma of her left breast, estrogen receptor-positive stage I (T(1a) N(1b) M(0)). The administration of tamoxifen, 20 mg/day, and doxifluridine, 600 mg/day, were started immediately postoperatively. Pelvic examination after admission revealed the left ovarian cyst and enlarged uterus. Transvaginal ultrasonography and computed tomography revealed a multilocular cystic mass in the pelvic cavity. The pathological diagnosis of the tumor after total hysterectomy and bilateral salpingo-oophorectomy was a typical follicular cyst with torsion and uterine leiomyoma. This ovarian cyst was believed to have developed during tamoxifen administration.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Oita, Japan. nasuk@fat.coara.or.jp
authors.forename: K
authors.initials: K
authors.lastname: Nasu
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kiyonaga
authors.forename: F
authors.initials: F
authors.lastname: Kawasaki
authors.forename: I
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000175:diagnosis; D010048:Ovarian Cysts / Q000139:chemically induced / Q000175:diagnosis* / Q000601:surgery; D010049:Ovarian Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D010052:Ovariectomy; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014102:Torsion Abnormality / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000175:diagnosis
chemical_list: D013629:Tamoxifen