title: The human caspase-activated DNase gene (hCAD): genomic structure, exonic single-nucleotide polymorphisms, and a highly polymorphic dinucleotide repeat at the hCAD locus.
abstract: Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. We determined its genomic structure and identified single-nucleotide polymorphisms (SNPs) within exons 5 and 7, as well as a highly polymorphic dinucleotide repeat of (CT)m(CA)n within the 5' region of the human CAD gene (hCAD). The genomic structure of hCAD presented here, together with information concerning SNPs within the gene, as well as a highly polymorphic (CT)m(CA)n repeat fragment at the hCAD locus, may assist in the construction of genetic maps for exploring gene(s) that play pivotal roles in carcinogenesis.
authors.affiliation: Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sugimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
authors.forename: F
authors.initials: F
authors.lastname: Saito-Ohara
authors.forename: R
authors.initials: R
authors.lastname: Kamiyama
authors.forename: A
authors.initials: A
authors.lastname: Nakagawara
authors.forename: N
authors.initials: N
authors.lastname: Mukae
authors.forename: S
authors.initials: S
authors.lastname: Nagata
authors.forename: J
authors.initials: J
authors.lastname: Inazawa
mesh_terms: D003851:Deoxyribonucleases / Q000235:genetics*; D018900:Dinucleotide Repeats / Q000235:genetics*; D005091:Exons / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D003851:Deoxyribonucleases; C109663:caspase-activated deoxyribonuclease