Intrafamilial occurrence of tubulointerstitial nephritis with uveitis and Vogt-Koyanagi-Harada syndrome.
We describe a child with acute tubular dysfunction, reversible renal failure, and uveitis, whose father has Vogt-Koyanagi-Harada syndrome. This is the first reported familial association of these 2 syndromes with distinctively overlapping clinical characteristics. A pathogenic association is proposed.
Zaoutis
L B
LB
Department of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
Rose
C D
CD
McKay
C P
CP
D002648:Child; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications / Q000235:genetics*; D014605:Uveitis / Q000150:complications / Q000235:genetics*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000235:genetics*