title: Increased I-131 uptake in local recurrence and distant metastases after second treatment with retinoic acid.
abstract: We present a case of increased I-131 uptake in a patient with papillary thyroid carcinoma with local recurrence and distant metastases after a second treatment with retinoic acid as a sign of redifferentiation of the tumor cells. When fine-needle aspiration cytology before and after a second course of retinoic acid treatment were compared, signs of tumor cell redifferentiation were found. This was accompanied by biochemical reexpression of thyroid marker proteins.
authors.affiliation: Clinic of Nuclear Medicine, University of Würzburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Koerber
authors.forename: C
authors.initials: C
authors.lastname: Schmutzler
authors.forename: J
authors.initials: J
authors.lastname: Rendl
authors.forename: J
authors.initials: J
authors.lastname: Koehrle
authors.forename: H
authors.initials: H
authors.lastname: Griesser
authors.forename: D
authors.initials: D
authors.lastname: Simon
authors.forename: C
authors.initials: C
authors.lastname: Reiners
mesh_terms: D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D015474:Isotretinoin / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*
chemical_list: D007457:Iodine Radioisotopes; D015474:Isotretinoin