Effects of apamin on memory processing of hippocampal-lesioned mice.
We investigated the effects of acute i.p. injections of the Ca(2+)-dependent K(+) channel blocker, apamin, on water maze spatial navigation and radial arm maze performance in mice with partial hippocampal-lesions. In the radial arm maze, apamin 0.06 and 0.2 mg/kg dose-dependently reversed the lesion-induced defect. In the water maze, apamin 0.2 mg/kg alleviated the defect, but a lower dose 0.06 mg/kg was ineffective. At a higher dose, 0.4 mg/kg, apamin impaired the water maze performance. These results suggest that Ca(2+)-dependent K(+) channel blockers can alleviate the spatial reference memory and working memory impairment induced by partial hippocampal lesions.
Ikonen
S
S
Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland. sami.ikonen@uku.fi
Riekkinen
P
P
D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D026902:Potassium Channel Blockers; D013997:Time Factors
D026902:Potassium Channel Blockers; D001030:Apamin; D002118:Calcium