A case of Werner's syndrome associated with osteosarcoma.
We described a case of Werner's syndrome associated with osteosarcoma. A 37-year-old Japanese man was diagnosed as having Werner's syndrome by the presence of juvenile cataracts, skin sclerosis and hyperpigmentation of the feet, high-pitched voice, characteristic bird-like appearance of the face with beak-shaped nose, thinning of the entire skin and hyperkeratoses on soles, hyperlipemia, hyperuricemia, diabetes melitus, and the mutated responsible gene (WRN). He had a 3-month history of a tumor on his left forearm. Histologically, the tumor included four histological patterns; a malignant fibrous histiocytoma-like, a desmoid-like, a dermatofibrosarcoma protuberans-like, and a chondrosarcoma-like pattern. Tumoral osteoid formation was also found in the tumor. Therefore, the tumor was diagnosed as osteosarcoma.
Murata
K
K
Department of Dermatology, Chiba University School of Medicine, Japan.
Hatamochi
A
A
Shinkai
H
H
Ishikawa
Y
Y
Kawaguchi
N
N
Goto
M
M
D000328:Adult; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D010375:Pedigree; D011884:Radius; D016896:Treatment Outcome; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy