title: Myopathy and neuropathy in rheumatoid arthritis. A quantitative controlled electromyographic study.
abstract: OBJECTIVE
  To test the hypothesis that patients with rheumatoid arthritis (RA) have clinical or subclinical evidence of peripheral neuropathy or myopathy.
  
  
  METHODS
  We studied 40 seropositive women with RA, mean age 46.6 years (SD 6.4), and 56 healthy controls, mean age 43.0 years (SD 9.1). Patients had a mean disease duration of 13.0 years (SD 7.8). We performed electromyographic examination of 4 muscles [extensor digitorum communis (EDC), biceps brachii (BB), vastus lateralis (VL), and tibialis anterior (TA)] on the right side in both groups. Quantitative data included percentage of polyphasic potentials, motor unit potential amplitude, area, duration, turns, and number of polyphasic potentials.
  
  
  RESULTS
  There were statistically significantly higher proportions of polyphasic potentials in 3 muscles in patients compared with controls. Mean number of phases in EDC was 4.6 (SD 0.4) in the patients and 4.1 (0.5) in controls (p = 0.0001). The values for the VL were 4.1 (SD 0.4) in patients compared with 3.6 (0.4) in controls (p = 0.0001), and in the TA 4.5 (SD 0.5) versus 4.0 (0.4) (p = 0.0001). We also found significantly increased duration of motor unit potentials in the VL and TA of patients. The amplitudes of motor unit action potentials were not significantly different in the 2 groups.
  
  
  CONCLUSIONS
  The study reveals an increased prevalence of neurogenic but not myogenic changes in patients with RA compared with controls.
authors.affiliation: Department of Neurology, University Hospital, Tromsö, Norway.
authors.forename: S I
authors.initials: SI
authors.lastname: Bekkelund
authors.forename: T
authors.initials: T
authors.lastname: Torbergsen
authors.forename: G
authors.initials: G
authors.lastname: Husby
authors.forename: S I
authors.initials: SI
authors.lastname: Mellgren
mesh_terms: D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000453:epidemiology / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000209:etiology*