title: Antioxidants and lipid peroxidation status in the blood of patients with psoriasis.
abstract: The aim of this research was to determine levels in blood of vitamin E, beta carotene, lipid peroxidation as malondialdehyde (MDA), reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity in patients with psoriasis. Studies were carried out on 34 patients with moderate and severe psoriases and healthy age-matched controls. Red blood cell (RBC) and plasma samples from healthy and patient subjects were taken. Levels of GSH and the activity of GSH-Px in both plasma and RBC samples were significantly (P<0.001) lower in patients with psoriasis than in controls, whereas beta carotene levels in plasma and MDA levels in RBC samples were significantly (P<0.01, P<0.001) higher in patients with psoriasis than in controls. However, vitamin E and MDA levels in plasma did not differ statistically. Although being far from conclusive, these results provide some evidence for a potential role of increased lipid peroxidation and decreased antioxidants in psoriasis.
authors.affiliation: Department of Dermatology, Medical Faculty of Firat University, 23119, Elaziğ, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Kökçam
authors.forename: M
authors.initials: M
authors.lastname: Naziroğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002648:Child; D004906:Erythrocyte Count; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*; D012016:Reference Values; D014810:Vitamin E / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005978:Glutathione