Finger pad tophi.
Hyperuricemia and gout are known to occur in patients receiving diuretic therapy. More recently recognized, however, is the occurrence of tophaceous gout in patients treated with cyclosporine. We report a 57-year-old man with normal renal function who was started on cyclosporine immediately after undergoing bilateral lung transplantation. Six months later, he developed progressive renal insufficiency and hypertension. In the following four months (10 months after starting his immunosuppressant medication), he presented with a symmetrical distribution of tophi on his finger pads. Seven previous cases of finger pad tophi have been reported and are reviewed.
Chopra
K F
KF
Department of Dermatology, New York-Presbyterian Hospital, Columbia Presbyterian Center, New York, USA.
Schneiderman
P
P
Grossman
M E
ME
D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005385:Fingers; D005500:Follow-Up Studies; D006073:Gout / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016040:Lung Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000601:surgery; D051437:Renal Insufficiency / Q000150:complications / Q000209:etiology*; D016896:Treatment Outcome; D014527:Uric Acid / Q000378:metabolism*
D006074:Gout Suppressants; D007166:Immunosuppressive Agents; D014527:Uric Acid; D016572:Cyclosporine