title: [Hypotension refractory to ephedrine after sympathetic blockade in a patient on long-term therapy with tricyclic antidepressants].
abstract: A 61-year-old woman in chronic treatment with 25 mg of amitriptyline underwent ovarian cancer resection under combined general and epidural lumbar anesthesia. After administration of local anesthetic she presented signs of severe arterial hypotension that was refractory to high doses of ephedrine and administration of dopamine alpha-adrenergic substances. Control was achieved with 200 micrograms of noradrenaline. We review the anesthetic implications of chronic use of tricyclic antidepressives as they affect choice of vasopressin for treating hypotensive events during anesthesia.
authors.affiliation: Servicio de Anestesia, Reanimación y Terapéutica del Dolor, Hospital Universitario Joan XXIII, Tarragona. sbp@tinet.fut.es
authors.forename: S
authors.initials: S
authors.lastname: Boada
authors.forename: B
authors.initials: B
authors.lastname: Solsona
authors.forename: J
authors.initials: J
authors.lastname: Papaceit
authors.forename: J
authors.initials: J
authors.lastname: Saludes
authors.forename: M
authors.initials: M
authors.lastname: Rull
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000639:Amitriptyline / Q000009:adverse effects* / Q000494:pharmacology; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000768:Anesthesia, General; D019162:Anesthetics, Combined / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects* / Q000494:pharmacology; D001340:Autonomic Nerve Block / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000601:surgery
chemical_list: D018759:Adrenergic Uptake Inhibitors; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000929:Antidepressive Agents, Tricyclic; D018765:Dopamine Uptake Inhibitors; D000639:Amitriptyline; D009638:Norepinephrine