[Tazarotene increases the antipsoriatic effect of dithranol in chronic psoriasis].
We examined whether it is possible to increase the antipsoriatic action by combining dithranol with a retinoid (tazarotene). In a randomized, open, prospective study with 50 psoriatic patients (22 females, 28 males, PASI>10) the antipsoriatic effectiveness of dithranol monotherapy to was compared combined therapy with dithranol and retinoid. The combination dithranol/retinoid (collective 2, reduction of the PASI from 17,2 to 2,8) revealed a significantly faster healing than the dithranol monotherapy (collective 1, reduction of the PASI from 18,5 to 4,8). The irritation of the combination therapy as evaluated with clinical score and laser doppler imaging was increased. Anti-psoriatic effectiveness of dithranol can be increased by combining it with tazarotene.
Sander
P
P
Dermatologische Klinik der Ruhr-Universität, Bochum im St.Josef-Hospital, Bochum.
Happe
M
M
Stücker
M
M
Hermes
N
N
Hoffmann
K
K
Altmeyer
P
P
D000875:Anthralin / Q000627:therapeutic use*; D002908:Chronic Disease; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D005782:Gels / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000627:therapeutic use*; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy*; D012176:Retinoids / Q000627:therapeutic use
D003879:Dermatologic Agents; D004338:Drug Combinations; D005782:Gels; D009539:Nicotinic Acids; D012176:Retinoids; C086827:tazarotene; D000875:Anthralin