Various extrahepatic manifestations caused by hepatitis C virus infection.
It has been reported that hepatitis C virus (HCV) causes not only liver disease but also disorders of other organs and tissues. Previously, many HCV-related extrahepatic manifestations have been reported. In this study, we report 2 patients in whom tongue cancer was detected during the treatment of HCV-related liver disease. In one patient, tongue cancer was detected during the treatment of HCV-related liver cirrhosis, and articular rheumatism developed thereafter. The duration of HCV-related liver disease was 10 years. In the other patient, tongue cancer was detected during the treatment of HCV-related hepatocellular carcinoma. This patient had a past history of thyroid disease. The duration of HCV-related liver disease was 6 years. In these patients, the possibility that several conditions incidentally and concurrently developed cannot be denied. However, the conditions described above may be regarded as HCV-related extra-hepatic manifestations. In patients with HCV infection, it is important to examine conditions in organs other than the liver. Careful follow-up is needed.
Nagao
Y
Y
Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830-0011, Japan.
Sata
M
M
Noguchi
S
S
Tajiri
N
N
Ono
N
N
Fukuda
T
T
Kameyama
T
T
Ueno
T
T
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000209:etiology*; D001327:Autoimmune Diseases / Q000209:etiology*; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008103:Liver Cirrhosis / Q000209:etiology; D008113:Liver Neoplasms / Q000209:etiology; D008875:Middle Aged; D014062:Tongue Neoplasms / Q000209:etiology*