ICln, an ion channel-forming protein associated with cell volume regulation.
It is not resolved whether the anionic channel involved in volume regulation after cell swelling comprises one or more subunits. Moreover, it remains to be determined which of the different proteins cloned so far, for which an involvement in cell volume regulation has been postulated, is the ideal candidate. In this review, we consider the role of the ICln protein, cloned from MDCK cells, in cell volume regulation.
Gschwentner
M
M
Department of Physiology, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020 Innsbruck, Austria.
Fürst
J
J
Ritter
M
M
Bazzini
C
C
Wöll
E
E
Dienstl
A
A
Jakab
M
M
König
M
M
Scandella
E
E
Rudzki
J
J
Botta
G
G
Meyer
G
G
Lang
F
F
Deetjen
P
P
Paulmichl
M
M
D000818:Animals; D048429:Cell Size / Q000502:physiology*; D018118:Chloride Channels / Q000235:genetics / Q000502:physiology*; D002874:Chromosome Mapping; D004594:Electrophysiology; D015870:Gene Expression; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D013314:Stress, Mechanical
D018118:Chloride Channels; D012333:RNA, Messenger