title: Reactions of healthy persons and persons suffering from allergic rhinitis when exposed to office dust.
abstract: OBJECTIVE
  Reactions to airborne office dust among healthy subjects and subjects suffering from allergic rhinitis were investigated.
  
  
  METHODS
  Twelve healthy and 11 subjects suffering from allergic rhinitis were exposed to clean air [17 (SD 2) microg/m3] and office dust [439 (SD 68) microg/m3] for 245 minutes. The effect measurements included subjective sensations (questionnaire and potentiometer ratings), mood scale, peak flow, bronchial provocation with histamine using forced expiratory volume in 1 second as the effect measure, nasal mucosal swelling, tear film stability, epithelial damage, foam formation in the eye canthus, threshold for eye irritation with carbon dioxide, eye redness, cellular content of conjunctival fluid, and an addition test for distraction. As many investigations were made and as many statistical analyses (including subgroup analyses) were carried out, the risk of mass significance appeared. This problem was dealt with using the Bonferroni correction for multiple significance tests.
  
  
  RESULTS
  The mean ratings of the potentiometer were higher (the subjects showed more irritation) during the dust exposure. The objective investigations showed only indications of effects of dust exposure, and some of the indications were in biologically unexplainable directions. No difference in the reactions to dust was observed between the healthy subjects and the subjects suffering from allergic rhinitis.
  
  
  CONCLUSIONS
  Dust does not seem to have objective or subjective effects on humans, as only indications of dust effects were found. Subjects suffering from allergic rhinitis do not appear to be a risk group in relation to dust exposure.
authors.affiliation: Department of Environmental and Occupational Medicine, University of Aarhus, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Hauschildt
authors.forename: L
authors.initials: L
authors.lastname: Mølhave
authors.forename: S K
authors.initials: SK
authors.lastname: Kjaergaard
mesh_terms: D000293:Adolescent; D000328:Adult; D001985:Bronchial Provocation Tests; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004391:Dust / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012016:Reference Values; D012221:Rhinitis, Allergic, Perennial / Q000150:complications* / Q000175:diagnosis; D012680:Sensitivity and Specificity; D018877:Sick Building Syndrome / Q000175:diagnosis / Q000209:etiology*
chemical_list: D004391:Dust