title: Propensity and mechanisms of restenosis in different coronary stent designs: complementary value of the analysis of the luminal gain-loss relationship.
abstract: OBJECTIVE
  This study sought to investigate the influence of stent design on the long-term angiographic outcome.
  
  
  BACKGROUND
  The proportional relationship between vessel injury and late luminal loss in percutaneous revascularization should be best appreciated in coronary stenting, where recoil and shrinkage are theoretically minimal. It is unclear whether all stent designs can counterbalance this reactive loss by achieving a large initial luminal gain (bigger is better).
  
  
  METHODS
  In 523 lesions successfully stented, the long-term angiographic results of slotted-tube (n = 331), coil (n = 85), multicellular (n = 70) and self-expandable mesh (n = 37) stent designs were compared using the angiographic gain-loss relationship (GLR).
  
  
  RESULTS
  Restenosis rate was 10% for multicellular, 20% for slotted-tube, 46% for coil and 49% for self-expandable designs (p = 0.001). At a difference with other designs, no significant GLR was found in coil stents, suggesting additional mechanisms of luminal loss (i.e., plaque protrusion, stent compression) to neointimal proliferation. Significant differences in late loss between stents were found within each quartile of luminal gain, suggesting a specific role of design in luminal loss. Multivariate analysis identified use of coil and self-expandable stents, vessel size, minimal luminal diameter preintervention, luminal gain and stent length as variables with independent predictive value for several indices of angiographic long-term outcome.
  
  
  CONCLUSIONS
  The analysis of GLR: 1) demonstrates that stent design influences late luminal loss; 2) challenges the applicability of the widely accepted "bigger is better" approach to all stent designs; and 3) appears as a valuable tool in assessing long-term stent performance.
authors.affiliation: Interventional Cardiology Unit, San Carlos University Hospital, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Escaned
authors.forename: J
authors.initials: J
authors.lastname: Goicolea
authors.forename: F
authors.initials: F
authors.lastname: Alfonso
authors.forename: M J
authors.initials: MJ
authors.lastname: Perez-Vizcayno
authors.forename: R
authors.initials: R
authors.lastname: Hernandez
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Ortiz
authors.forename: C
authors.initials: C
authors.lastname: Bañuelos
authors.forename: C
authors.initials: C
authors.lastname: Macaya
mesh_terms: D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology*; D004867:Equipment Design; D006801:Humans; D012008:Recurrence; D012044:Regression Analysis; D015607:Stents