title: Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair.
abstract: OBJECTIVE
  To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation.
  
  
  METHODS
  The radiology department of a tertiary referral centre.
  
  
  METHODS
  14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging.
  
  
  METHODS
  Biventricular volumes, global biventricular function, and regional left ventricular function were assessed in all subjects.
  
  
  RESULTS
  The amount of pulmonary regurgitation in patients (mean (SD)) was 25 (18)% of forward flow and correlated significantly with right ventricular enlargement (p < 0.05). Left ventricular end diastolic volume was decreased in patients (78 (11) v 88 (10) ml/m(2); p < 0.05), ejection fraction was not significantly altered (59 (5)% v 55 (7)%; NS). No significant correlation was found between pulmonary regurgitation and left ventricular function. Overall left ventricular end diastolic wall thickness was significantly lower in patients (5.06 (0.72) v 6.06 (1.06) mm; p < 0. 05), predominantly in the free wall. At the apical level, left ventricular systolic wall thickening was 20% higher in Fallot patients (p < 0.05). Left ventricular shape was normal.
  
  
  CONCLUSIONS
  Adult Fallot patients with mild chronic pulmonary regurgitation and subsequent right ventricular enlargement showed a normal left ventricular shape and global function. Although the left ventricular free wall had reduced wall thickness, compensatory hypercontractility of the apex may contribute to preserved global function.
authors.affiliation: Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: Niezen
authors.forename: W A
authors.initials: WA
authors.lastname: Helbing
authors.forename: E E
authors.initials: EE
authors.lastname: van Der Wall
authors.forename: R J
authors.initials: RJ
authors.lastname: van Der Geest
authors.forename: H W
authors.initials: HW
authors.lastname: Vliegen
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D011665:Pulmonary Valve Insufficiency / Q000503:physiopathology*; D013318:Stroke Volume; D013771:Tetralogy of Fallot / Q000503:physiopathology / Q000601:surgery*; D016277:Ventricular Function, Left / Q000502:physiology*