Parenchymal cell proliferation in coronary arteries after percutaneous transluminal coronary angioplasty: a human tissue bank study.
OBJECTIVE
Restenosis after percutaneous transluminal coronary angioplasty (PTCA) remains a limitation of this technique. Arterial wall cell proliferation is a component of restenosis preventable with intravascular brachytherapy. This study attempts to locate the sites of cellular proliferation after PTCA so as to aid the optimization of this therapy.


METHODS
Autopsy records from January 1, 1985 through December 31, 1995 were reviewed, and 27 patients who received PTCA prior to death were identified who also had evidence of PTCA on histologic examination of the arterial sections. The sections were subjected to immunohistochemical staining for proliferating cell nuclear antigen (PCNA) to detect the proliferating cells in the arterial sections, followed by image analysis to determine the proliferative index (PI) of all regions and layers of the section.


RESULTS
The PI did not differ significantly according to vessel region (plaque, plaque shoulder, or portion of vessel wall with lowest plaque burden), vessel layer (intima, media, adventitia), or evidence of prior PTCA. There was a trend toward a higher PI in young lesions.


CONCLUSIONS
Cell proliferation in the vascular wall after PTCA was found throughout the treated arterial section's axial plane, not only in the periluminal region.
Ciezki
J P
JP
The Department of Radiation Oncology, The Cleveland Clinic Foundation, OH 44195, USA. ciezki@radonc.ccf.org
Häfeli
U O
UO
Song
P
P
Urankar-Nagy
N
N
Ratliff
N B
NB
Rybicki
L
L
Brill
K
K
Meier
D
D
D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000032:analysis; D001918:Brachytherapy; D002455:Cell Division; D002467:Cell Nucleus / Q000737:chemistry; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012008:Recurrence; D014654:Vascular Patency
D015415:Biomarkers; D018809:Proliferating Cell Nuclear Antigen