On the trabecular "thickness"-number problem.
The decrease in trabecular number with aging and in osteoporosis seems to be naturally irreversible. In one view the resulting loss of bone strength would be irreversible too, but in another view the remaining trabeculae could increase their strength, chiefly by thickening. Whether that can occur has become important for osteoporosis research and management as well as for some biomechanical issues. This article reviews evidence and ideas that concern that matter. It suggests why the second view could be correct although previous studies did not detect it. However, that view still needs the kind of proof the general skeletal science community could accept.
Frost
H M
HM
Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo, Colorado, USA.
D000375:Aging; D000818:Animals; D006801:Humans; D010024:Osteoporosis / Q000473:pathology / Q000503:physiopathology*