Mucin-type O-glycans and leukosialin.
Mucin-type O-glycans on leukocytes acquire functions once they contain core 2 branches, which can be synthesized by core 2 beta1,6-N-acetylglucosaminyltransferase (C2GnT). Recently, understanding the roles of mucin-type O-glycans has been significantly advanced by generating transgenic mice overexpressing C2GnT or knockout mice defective in C2GnT. This review article summarizes previous results implicating the roles of mucin-type O-glycans and the most recent studies to test such a hypothesis. These results, taken together, demonstrate that mucin-type O-glycans either facilitate or attenuate cell adhesion depending on the structures of non-reducing termini.
Fukuda
M
M
The Glycobiology Program, Cancer Research Center, Burnham Institute, La Jolla, CA 92037, USA. minoru@burnham-inst.org
Tsuboi
S
S
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis; D002240:Carbohydrate Sequence; D002448:Cell Adhesion; D002460:Cell Line; D018076:DNA, Complementary / Q000737:chemistry; D006801:Humans; D051917:Leukosialin; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009077:Mucins / Q000378:metabolism*; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics / Q000378:metabolism*; D009844:Oligosaccharides / Q000032:analysis; D012795:Sialoglycoproteins / Q000737:chemistry* / Q000235:genetics; D013601:T-Lymphocytes / Q000737:chemistry / Q000201:enzymology / Q000276:immunology; D013950:Thymus Gland / Q000737:chemistry / Q000166:cytology; D014407:Tumor Cells, Cultured; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D018076:DNA, Complementary; D051917:Leukosialin; D007983:Lewis Blood Group Antigens; D016256:Lewis X Antigen; D009077:Mucins; D009844:Oligosaccharides; C465014:SPN protein, human; D012795:Sialoglycoproteins; C111125:lewis(a)-lewis(x); D017351:N-Acetylglucosaminyltransferases; C117361:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; C053024:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-acetylglucosaminyl transferase