[The therapeutic activity of synthetic peptides, analogs of the renal natural peptide complex, in the late periods of a toxic lesion by ethylene glycol].
The purpose of the work was study of the therapeutic activity of synthetic peptides, analogs of the natural renal peptide complexes, in late-term sequelae of a toxic affection caused by oral administration of ethylene glycol. Quite moderate disorders of renal function were encountered in the late-term periods after affection of the hepatic parenchyma. Under such conditions all the peptides under study produced a therapeutic effect, but of a different degree. It is thus obvious that study of these synthetic peptides, analogs of the natural renal complex, as potential drugs for the prevention of late-term toxic disorders of renal function is promising.
Gaĭko
O A
OA
Central Research Laboratory, Ukranian Medical Stomatological Academy, Poltava, Ukraine.
Kaĭdashev
I P
IP
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D019855:Ethylene Glycol / Q000633:toxicity*; D005260:Female; D007668:Kidney; D008297:Male; D008647:Mesocricetus; D009393:Nephritis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D009842:Oligopeptides / Q000627:therapeutic use*; D010455:Peptides; D013997:Time Factors
D000931:Antidotes; D009842:Oligopeptides; D010455:Peptides; C115480:prolyl-glycyl-lysyl-aspartyl-aspartyl-arginyl-leucine; C115478:prolyl-glycyl-lysyl-aspartyl-leucyl-arginyl-lysine; C115479:prolyl-glycyl-lysyl-aspartyl-seryl-arginyl-lysine; D019855:Ethylene Glycol