The impact of L-arginine-nitric oxide metabolism on ischemia/reperfusion injury.
Several experimental studies have revealed that the administration of L-arginine can reduce ischemia/reperfusion injury to skeletal muscle, kidney, liver, heart and brain. Moreover, the administration of L-arginine can cause protective hemodynamic alterations. However, in situations with a stimulated inducible NOS, the administration of large amounts of L-arginine may be hazardous for the patients.
Roth
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Chirurgische Forschungslaboratorien, Universitätsklinik für Chirurgie/AKH, Wien, Austria.
D000818:Animals; D001120:Arginine / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D016031:Liver Transplantation; D009569:Nitric Oxide / Q000378:metabolism*; D011183:Postoperative Complications / Q000628:therapy; D015427:Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control*
D009569:Nitric Oxide; D001120:Arginine