Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus.
OBJECTIVE
To assess the association between polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) and systemic erythematosus (SLE) in Japanese people.


METHODS
We examined the IL-10 receptor genotype of 109 SLE patients and 102 healthy subjects by the reverse transcription-polymerase chain reaction-restriction fragment length polymorphism (RT-PCR-RFLP) method.


RESULTS
There was no difference in the IL10R genotype frequencies of these two groups.


CONCLUSIONS
The IL10R genotype does not determine susceptibility to SLE in Japanese people.
Nakashima
H
H
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Akahoshi
M
M
Tanaka
Y
Y
Yamaoka
K
K
Ogami
E
E
Nagano
S
S
Arinobu
Y
Y
Niiro
H
H
Otsuka
T
T
Niho
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D018076:DNA, Complementary / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018123:Receptors, Interleukin / Q000235:genetics*; D053701:Receptors, Interleukin-10; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018076:DNA, Complementary; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10