title: The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization.
abstract: Recent evidence indicates that the type of atherosclerotic plaque, rather than the degree of obstruction to flow, is an important determinant of the risk of cardiovascular complications. In previous work, the feasibility of using MRI for the characterization of plaque components was shown. This study extends the previous work to all the plaque components and shows the accuracy of this method. Twenty-two human carotid endarterectomy specimens underwent ex vivo MRI and histopathological examination. Sixty-six cross sections were matched between MRI and histopathology. In each cross section, the presence or absence of plaque components were prospectively identified on the MRI images. The overall sensitivity and specificity for each tissue component were very high. Calcification and fibrocellular tissue were readily identified. Lipid core was also identifiable. However, thrombus was the plaque component for which MRI had the lowest sensitivity. A semiautomated algorithm was created to identify all major atherosclerotic plaque components. MRI can characterize carotid artery plaques with a high level of sensitivity and specificity. Application of these results in the clinical setting may be feasible in the near future.
authors.affiliation: Cardiovascular Institute, Department of Medicine, New York, NY, USA. meir_shinnar@smtplink.mssm.edu
authors.forename: M
authors.initials: M
authors.lastname: Shinnar
authors.forename: J T
authors.initials: JT
authors.lastname: Fallon
authors.forename: S
authors.initials: S
authors.lastname: Wehrli
authors.forename: M
authors.initials: M
authors.lastname: Levin
authors.forename: D
authors.initials: D
authors.lastname: Dalmacy
authors.forename: Z A
authors.initials: ZA
authors.lastname: Fayad
authors.forename: J J
authors.initials: JJ
authors.lastname: Badimon
authors.forename: M
authors.initials: M
authors.lastname: Harrington
authors.forename: E
authors.initials: E
authors.lastname: Harrington
authors.forename: V
authors.initials: V
authors.lastname: Fuster
mesh_terms: D000465:Algorithms; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000601:surgery; D002339:Carotid Arteries / Q000473:pathology* / Q000601:surgery; D016894:Endarterectomy, Carotid; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity