Idiopathic myelofibrosis with extramedullary hematopoiesis in the kidneys.
Extramedullary hematopoiesis is a common finding in idiopathic myelofibrosis and is usually found in liver and spleen. We report on a patient with biopsy-proven myeloid metaplasia and fibrosis of the renal parenchyma as a rare cause of chronic renal failure. The renal biopsy specimen showed numerous infiltrates of hematopoietic cells expressing growth factors like M-CSF, GM-CSF, IL-1beta and PDGF while TGF-beta was not elevated. These findings suggest that hematopoietic growth factors play a key role in the pathogenesis of this condition causing proliferating fibrosis and enlargement of the kidneys.
Schnuelle
P
P
Vth Medical Clinic, Medical Faculty of the University of Heidelberg, Germany.
Waldherr
R
R
Lehmann
K J
KJ
Woenckhaus
J
J
Back
W
W
Niemir
Z
Z
van der Woude
F J
FJ
D000368:Aged; D001706:Biopsy; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000473:pathology; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology*