title: Ocular findings in HIV-1 positive and HIV-1 negative participants in a rural population-based cohort in Uganda.
abstract: OBJECTIVE
  To report the ocular findings in HIV-1 seropositive individuals and HIV-negative controls in a population-based cohort in rural Uganda.
  
  
  METHODS
  Participants were examined by an ophthalmologist, who was unaware of their HIV-status.
  
  
  RESULTS
  238 participants were examined, 43 were HIV-1 prevalent cases (infected prior to 1990); 62 were HIV-1 incident cases and 133 were HIV-negative controls. Eleven of the HIV-positive participants had AIDS, and a further 8 had a CD4 count of less than 200 cells/mm3. Bilateral low vision was recorded in 9 participants and cataracts were the main cause of bilateral low vision. The mean intra-ocular pressure (IOP) was 12.6 mm Hg, and no association was found between IOP and CD4 lymphocyte count. Although significantly more HIV positives had some sign of intraocular inflammation compared to the negatives (p = 0.02) there was no significant linear trend in the HIV positives with decreasing CD4 count. Overall, 11 (26%) prevalent, 6 (10%) incident cases and 8 (6%) HIV-negatives controls had some evidence of intraocular inflammation, however, only one person had reduced visual acuity attributable to these lesions. Punctate epithelial erosions and keratic precipitates in the anterior chamber were seen significantly more frequently in HIV-positives compared to the HIV-negative controls. Cotton wool spots were not seen.
  
  
  CONCLUSIONS
  A substantial proportion of HIV-infected persons had ocular findings which may have been attributable to their infection, however in only one case did this result in reduced visual acuity. Although the ocular complications of AIDS seem to comprise a large extra element in the work load of tertiary care hospitals dealing with eye problems, on a population basis such cases are infrequent.
authors.affiliation: Medical Research Council Programme on AIDS/Uganda Virus Research Institute, Entebbe.
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Whitworth
authors.forename: A
authors.initials: A
authors.lastname: Ross
authors.forename: G
authors.initials: G
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005128:Eye Diseases / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012424:Rural Population; D014454:Uganda / Q000453:epidemiology
chemical_list: D015483:HIV Antibodies