Improvement of the intestinal absorption of a peptidomimetic, boronic acid thrombin inhibitor possibly utilizing the oligopeptide transporter.
Saitoh
H
H
DuPont Pharmaceuticals Research Laboratories, Wilmington, Delaware 19880-0400, USA.
Aungst
B J
BJ
D000818:Animals; D000991:Antithrombins / Q000493:pharmacokinetics*; D001896:Boron Compounds / Q000493:pharmacokinetics*; D002352:Carrier Proteins / Q000378:metabolism*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D009842:Oligopeptides / Q000378:metabolism* / Q000493:pharmacokinetics*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000991:Antithrombins; D001896:Boron Compounds; D002352:Carrier Proteins; D009842:Oligopeptides; C066061:acetylphenylalanyl-prolyl-boroarginine; D010649:Phenylalanine