title: Phytotoxins from the leaves of Laggera decurrens.
abstract: Upon biological screening of a series of African medicinal plants, substantial phytotoxic activity was found in the leaves of Laggera decurrens (Vahl.) Hepper & Wood (Asteraceae), using a Lemna minor bioassay. Bioassay-guided fractionation of the leaves led to the isolation of two physiologically active compounds: 3-hydroxythymoquinone and 5-acetoxy-2-hydroxythymol, causing death of Lemna minor in the 25-100 microM range. Symptoms were a rapidly developing chlorosis, followed by necrosis of fronds. The compounds also inhibited growth and germination of the grass weed Agrostis capillaris down to 250 microM. The mode of action of both compounds could not be elucidated, but they do not appear to be photosystem II inhibitors.
authors.affiliation: Departments of Organic Chemistry and Plant Production, University of Gent, Belgium. luc.vanpuyvelde@rug.ac.be
authors.forename: L
authors.initials: L
authors.lastname: Van Puyvelde
authors.forename: J
authors.initials: J
authors.lastname: Bosselaers
authors.forename: C
authors.initials: C
authors.lastname: Stevens
authors.forename: N
authors.initials: N
authors.lastname: De Kimpe
authors.forename: J
authors.initials: J
authors.lastname: Van Gestel
authors.forename: P
authors.initials: P
authors.lastname: Van Damme
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D006540:Herbicides; D019684:Magnoliopsida / Q000187:drug effects* / Q000254:growth & development; D016488:Medicine, African Traditional; D009276:Namibia; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D006540:Herbicides; D010936:Plant Extracts