title: Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy.
abstract: We have observed a falsely lateralizing mesial temporal [11C]-flumazenil binding asymmetry in three patients who had temporal lobe epilepsy (TLE) with normal hippocampal volumes. This abnormality was not detected 3 months later in two of the patients who underwent a second PET study. We conclude that transient and falsely lateralizing changes of flumazenil binding might occur in patients with TLE and no hippocampal sclerosis.
authors.affiliation: Department of Functional Neurology and Epileptology, CERMEP, Neurological Hospital, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Ryvlin
authors.forename: S
authors.initials: S
authors.lastname: Bouvard
authors.forename: D
authors.initials: D
authors.lastname: Le Bars
authors.forename: F
authors.initials: F
authors.lastname: Mauguière
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005442:Flumazenil / Q000493:pharmacokinetics*; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D012016:Reference Values; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D005442:Flumazenil