title: Idiopathic calcinosis cutis presenting as labial lesions in children: report of two cases with literature review.
abstract: BACKGROUND
  Calcinosis cutis is a general term for calcium deposition in the skin. It may be due to abnormal calcium or phosphorus metabolism, damage to the dermal collagen, or idiopathic. It has been found in the skin of many areas of the body, including the face, extremities, penis, scrotum and mons pubis. We report two cases of calcinosis cutis presenting as lesions of the labia majora in children.
  
  
  METHODS
  A 6 1/2-year-old girl presented with labial lesions of unknown etiology. There was no history of sexual abuse or trauma. Excisional biopsy was performed and histopathological evaluation showed subepithelial calcification. Follow-up laboratory evaluation revealed normal serum calcium and phosphorus levels. Screening tests for collagen vascular diseases were negative. An 8-year-old girl presented for evaluation of a "labial cyst." The lesion was first noted 6 months prior to presentation and had not resolved, despite treatment with topical creams and sitz baths. Excisional biopsy was performed and histopathological evaluation showed multiple nodules of calcified and amorphous debris surrounded by histiocytes and giant cells.
  
  
  CONCLUSIONS
  We report two cases of idiopathic calcinosis cutis presenting as labial lesions in children. Because it can be mistaken for a sexually transmitted disease, recognition and proper diagnosis of this condition is essential. Additionally, work-up to rule out abnormalities of phosphorus or calcium metabolism and collagen vascular diseases may be indicated.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
authors.forename: B D
authors.initials: BD
authors.lastname: Bernardo
authors.forename: P C
authors.initials: PC
authors.lastname: Huettner
authors.forename: D F
authors.initials: DF
authors.lastname: Merritt
authors.forename: V S
authors.initials: VS
authors.lastname: Ratts
mesh_terms: D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology*; D002648:Child; D002650:Child Abuse, Sexual / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D014844:Vulva / Q000473:pathology; D014845:Vulvar Diseases / Q000175:diagnosis / Q000473:pathology*