Biomechanical factors in tissue engineered meniscal repair.
Damage to the meniscus after trauma or injury is associated with detrimental changes in joint function that can lead to pain, disability, and degenerative joint changes. Recently, tissue engineering strategies for meniscal repair have been suggested including using biocompatible grafts as a substrate for regeneration, and cellular supplementation to promote remodeling and healing. Little is known, however, about the contributions of these novel repair strategies to restoration of normal meniscal function. Biomechanical factors play a role in the design and synthesis of tissue engineered biomaterials and bioreactors, and also are important for evaluating the efficacy of these new strategies for restoring normal meniscal function. In this report, an overview is presented of biomechanical factors that are critical to meniscal function followed by a review of biomechanical considerations for the design and evaluation of tissue engineered strategies for meniscal repair. Recommendations for future study of biomechanical factors in tissue engineered meniscal repair also are provided.
Setton
L A
LA
Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281 USA.
Guilak
F
F
Hsu
E W
EW
Vail
T P
TP
D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001709:Biotechnology; D018929:Cell Culture Techniques; D017690:Cell Transplantation; D008592:Menisci, Tibial / Q000166:cytology* / Q000502:physiology* / Q000601:surgery; D012038:Regeneration
D001672:Biocompatible Materials