title: mRNA quantification of C-type natriuretic peptide in brain areas of rodents.
abstract: C-type natriuretic peptide (CNP) is regarded as an endothelium-derived vasodilator and might therefore have an important role in controlling vascular tone and remodeling. Because CNP also is expressed in the brain, it is considered to be a neurotransmitter. The present study compares expression levels of CNP mRNA in distinct areas of the mouse brain with the expression pattern in the rat brain. A distinct expression of CNP was found in all investigated areas with the exception of the mouse striatum. In both rodents, high CNP expression was detected in the tegmentum.
authors.affiliation: Department of Obstetrics and Gynecology, University of Leipzig, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Stepan
authors.forename: E
authors.initials: E
authors.lastname: Leitner
authors.forename: W E
authors.initials: WE
authors.lastname: Siems
authors.forename: B
authors.initials: B
authors.lastname: Maul
authors.forename: T
authors.initials: T
authors.lastname: Walther
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D015870:Gene Expression; D051379:Mice; D008810:Mice, Inbred C57BL; D020098:Natriuretic Peptide, C-Type / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger; D051381:Rats; D011921:Rats, Inbred WKY; D012377:Rodentia
chemical_list: D012333:RNA, Messenger; D020098:Natriuretic Peptide, C-Type