title: Long-term ciprofloxacin treatment for the prevention of biliary stent blockage: a prospective randomized study.
abstract: OBJECTIVE
  In vitro experimental and animal studies have shown that quinolones reduce the adherence of bacteria on a polyethylene tube and prevent stent blockage. Our aim was to see whether ciprofloxacin prevents stent blockage in patients with malignant stricture of the biliary tract.
  
  
  METHODS
  Patients with inoperable biliary or pancreatic tumor not involving the bifurcation of the common hepatic duct were recruited. They were randomized to receive either endoscopic stenting alone or stenting with prophylactic treatment of ciprofloxacin (200 mg i.v. before stenting, followed by 250 mg orally twice per day). In each follow-up visit, clinical symptoms of cholangitis were documented and blood samples taken for blood counts, serum levels of bilirubin, and alkaline phosphatase. Stent blockage was defined as clinical symptom(s) of cholangitis with biochemical or radiological evidence of stent dysfunction.
  
  
  RESULTS
  Fifty-eight patients were recruited into the study. Three patients in the stenting group and three in the ciprofloxacin group were excluded after randomization. Eleven patients received stenting alone and five patients receiving ciprofloxacin had previous endoscopic stenting. Thirteen patients (50%) in the ciprofloxacin group and eight patients (31%) in the stenting group died before stent blockage. Ten patients (38%) in each group had stent blockage during the follow-up at 20 wk. The median stent patency was 11.6 wk and 11.9 wk in the ciprofloxacin group and the stenting group, respectively. Kaplan-Meier analysis of stent patency showed no difference between the two groups. Among patients who received endoscopic stenting for the first time, there was a trend favoring ciprofloxacin treatment, but the difference was not significant. The 30-day and 20-wk mortality between the groups were comparable.
  
  
  CONCLUSIONS
  Long-term use of ciprofloxacin does not prevent blockage of polyethylene biliary stents.
authors.affiliation: Endoscopy Center, Prince of Wales Hospital, The Chinese University of Hong Kong.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sung
authors.forename: J D
authors.initials: JD
authors.lastname: Sollano
authors.forename: C W
authors.initials: CW
authors.lastname: Lai
authors.forename: A
authors.initials: A
authors.lastname: Ismael
authors.forename: M Y
authors.initials: MY
authors.lastname: Yung
authors.forename: I
authors.initials: I
authors.lastname: Tumala
authors.forename: S C
authors.initials: SC
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000150:complications; D001663:Bilirubin / Q000097:blood; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000209:etiology; D002779:Cholestasis / Q000209:etiology / Q000517:prevention & control*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003137:Common Bile Duct Diseases / Q000209:etiology / Q000517:prevention & control*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications; D011446:Prospective Studies; D015607:Stents; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D000469:Alkaline Phosphatase; D001663:Bilirubin