Tubular epithelial cells: A critical cell type in the regulation of renal inflammatory processes.
Most chronic human kidney diseases are characterized by a final common pathway consisting of interstitial inflammation and ultimately leading to interstitial fibrosis. Within this process, tubular epithelial cells (TECs) play a critical role. Both in vitro and in vivo it has been demonstrated that TECs are an important source of various cytokines, chemokines, growth factors, adhesion molecules and extracellular matrix components. In the present review we will outline the capacity of TECs to produce inflammatory mediators and discuss the different mechanisms involved in the regulation of production of these mediators.
van Kooten
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Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Kooten@rullf2.Medfac.LeidenUniv.nl
Daha
M R
MR
van Es
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LA
D000818:Animals; D019013:CD40 Antigens / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007684:Kidney Tubules / Q000473:pathology*; D009393:Nephritis / Q000503:physiopathology*
D019013:CD40 Antigens; D018836:Inflammation Mediators