Synthesis of chiral carbocyclic ribonucleotides.
The carbocyclic analogs of CMP, UMP, GMP, IMP, and ribo-TMP, of the same absolute configuration as the naturally occurring beta-D-ribofuranose-based ribonucleoside monophosphates, have been synthesized. The synthetic route employed Mitsunobu coupling of the heterocycles, appropriately protected where necessary, with a differentially protected, chiral carbocyclic core.
Antle
V D
VD
Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati Medical Center, OH 45267-0004, USA.
Caperelli
C A
CA
D008968:Molecular Conformation; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis; D012265:Ribonucleotides / Q000138:chemical synthesis*
D012263:Ribonucleosides; D012265:Ribonucleotides