title: Natural history of human immunodeficiency virus type 1 infection in children: a five-year prospective study in Rwanda. Mother-to-Child HIV-1 Transmission Study Group.
abstract: OBJECTIVE
  To compare morbidity and mortality of human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected children and to identify predictors of acquired immunodeficiency syndrome (AIDS) and death among HIV-1-infected children in the context of a developing country.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Maternal and child health clinic of the Centre Hospitalier de Kigali, Rwanda.
  
  
  METHODS
  Two hundred eighteen children born to HIV-1-seropositive mothers and 218 born to seronegative mothers of the same age and parity were enrolled at birth.
  
  
  METHODS
  Deaths, clinical AIDS, nonspecific HIV-related manifestations, and use of health care services.
  
  
  RESULTS
  Fifty-four infected and 347 uninfected children were followed up for a median of 27 and 51 months, respectively. With the exception of chronic cough, the risk of occurrence of nonspecific HIV-related conditions was 3 to 13 times higher in infected than in uninfected children. The recurrence rate and severity of these findings were increased systematically in infected infants. Estimated cumulative risk of developing AIDS was 28% and 35% at 2 and 5 years of age, respectively. Estimated risk of death among infected children at 2 and 5 years of age was 45% and 62%, respectively, a rate 21 times higher than in uninfected children. Median survival time after estimated infection was 12.4 months. Early infection, early onset of HIV-related conditions, failure to thrive, and generalized lymphadenopathy were associated with subsequent risk of death and/or AIDS, whereas lymphoid interstitial pneumonitis was predictive of a milder disease.
  
  
  CONCLUSIONS
  In Africa, HIV-1-infected children develop disease manifestations early in life. Specific clinical findings are predictive of HIV-1 disease, AIDS stage, and death. Bimodal expression of HIV-1 pediatric disease is encountered in Africa, as in industrialized countries, but prognosis is poorer. human immunodeficiency virus infection, children, vertical transmission, natural history, Africa.
authors.affiliation: Unité INSERM U 330, Université Victor Segalen Bordeaux 2, Bordeaux, France. rosemary.spira@dim.u-bordeaux2.fr
authors.forename: R
authors.initials: R
authors.lastname: Spira
authors.forename: P
authors.initials: P
authors.lastname: Lepage
authors.forename: P
authors.initials: P
authors.lastname: Msellati
authors.forename: P
authors.initials: P
authors.lastname: Van De Perre
authors.forename: V
authors.initials: V
authors.lastname: Leroy
authors.forename: A
authors.initials: A
authors.lastname: Simonon
authors.forename: E
authors.initials: E
authors.lastname: Karita
authors.forename: F
authors.initials: F
authors.lastname: Dabis
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D002675:Child, Preschool; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000635:transmission; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009026:Mortality; D009035:Mothers; D011446:Prospective Studies; D012432:Rwanda / Q000453:epidemiology; D016019:Survival Analysis