Functional integration of neural grafts in Parkinson's disease.
Functional imaging in a Parkinson's patient with a neural transplant shows that the graft is still functional after ten years, and that dopamine from the graft can bind to postsynaptic sites.
Barker
R A
RA
Dunnett
S B
SB
D000661:Amphetamine / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D016380:Brain Tissue Transplantation; D018849:Controlled Clinical Trials as Topic; D004298:Dopamine / Q000378:metabolism*; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000637:transplantation*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D020891:Raclopride / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D014055:Tomography, Emission-Computed / Q000379:methods
D017448:Receptors, Dopamine D2; D020891:Raclopride; D000661:Amphetamine; D004298:Dopamine