Complications following balloon-occluded arterial infusion chemotherapy for pelvic malignancies.
OBJECTIVE
To evaluate the incidence and causes of complications associated with balloon-occluded arterial infusion chemotherapy (BOAI) for pelvic malignancies.


METHODS
In 34 courses of BOAI in 22 patients with pelvic malignancies, we analyzed the incidence of complications as well as the effect of the dose of the anticancer drugs, the infusion site, and the number of BOAI administrations on these complications. Complications were divided into two categories: cystitis-like symptoms and neurological complications such as pain, numbness, and paresthesia of the lower extremities and the hip.


RESULTS
Eleven patients (50%) suffered from complications, seven (31.8%) from neurological complications and four (18.2%) from cystitis-like symptoms. The complications appeared in 14 courses (42. 4%) of BOAI, neurological complications in 10 (30.3%) and cystitis-like symptoms in four (12.1%). A high dose of anti-cancer drugs and infusion from the anterior division tended to induce neurological complications more frequently; however, the cystitis-like symptoms were not related to any factors.


CONCLUSIONS
Our results indicate that a smaller dose of anti-cancer drugs should be infused from the bilateral internal iliac arteries for safer pelvic BOAI.
Sugimoto
K
K
Department of Radiology, Nishi-Kobe Medical Center, 5-7-1 Koji-dai, Nishi-ku, Kobe 651-2273, Japan.
Hirota
S
S
Imanaka
K
K
Kawabe
T
T
Nakayama
Y
Y
Takeuchi
Y
Y
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007083:Iliac Artery; D015994:Incidence; D007261:Infusions, Intra-Arterial / Q000009:adverse effects / Q000379:methods; D008297:Male; D010386:Pelvic Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents