Function for NF-kB in neuronal survival: regulation by atypical protein kinase C.
Activation of the transcription factor nuclear factor kappa B (NF-kB) has been intensely studied in the past several years due to its role as an inducible regulator of inflammation, apoptosis, transformation, and oncogenesis. Recently, increasing evidence supports a role for NF-kB in regulation of anti-apoptotic gene expression and promotion of cell survival (May and Ghosh [1999] Science 284:272-273). Studies in the past 5 years have provided evidence that NF-kB regulates neuronal survival as well. Moreover, atypical protein kinase (aPKC) has been shown to play a novel role in modulating the NF-kB pathway. In this review, I focus on neurons and the factors that contribute to regulation of NF-kB via aPKC.
Wooten
M W
MW
Department of Biological Sciences, Auburn University, Auburn, Alabama, USA. mwwooteen@ag.auburn.edu
D000818:Animals; D002470:Cell Survival / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000235:genetics* / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry* / Q000502:physiology*; D011493:Protein Kinase C / Q000235:genetics* / Q000378:metabolism*
D016328:NF-kappa B; C115015:PKC-3 protein; D011493:Protein Kinase C