title: Risk/protective factors among addicted mothers' offspring: a replication study.
abstract: There are few systematic studies of the school-aged offspring of drug-dependent patients, although this information is useful for planning evidence-based prevention programs. We have completed such a study, which we compare to a similar study independently conducted in 1998. In both studies, both the parent and offspring were assessed blindly and independently by direct diagnostic interviews, and parental assessment of offspring was also obtained. The similarity in design and methods between studies provided an opportunity for replication by reanalysis of data. The major findings are a replication in two independently conducted studies of school-aged offspring of opiate- and/or cocaine-addicted mothers of the high rates of any psychiatric disorder (60% in both studies), major depression (20%, 26%), oppositional defiant disorder (ODD) (18%, 23%), conduct disorder (17%, 9%), attention-deficit/hyperactivity disorder (ADHD) (13%, 8%), and substance abuse (5%, 10%) among offspring. Both studies also found high rates of comorbid alcohol abuse, depression, and multiple drugs of abuse in the mothers. We conclude that efforts to replicate findings by analyses of independently conducted studies are an inexpensive way to test the sturdiness of findings that can provide the empirical basis for preventive efforts. Clinically, the data in both studies suggest that both drug dependence and associated psychopathology should be assessed and treated in opiate addicts with young offspring, and the offspring should be monitored for the development of conduct and mood disorders and substance use.
authors.affiliation: Department of Clinical and Genetic Epidemiology, New York State Psychiatric Institute, New York, New York 10032, USA. weissmanchild.cpmc.columbia.edu.
authors.forename: M M
authors.initials: MM
authors.lastname: Weissman
authors.forename: G
authors.initials: G
authors.lastname: McAvay
authors.forename: R B
authors.initials: RB
authors.lastname: Goldstein
authors.forename: E V
authors.initials: EV
authors.lastname: Nunes
authors.forename: H
authors.initials: H
authors.lastname: Verdeli
authors.forename: P J
authors.initials: PJ
authors.lastname: Wickramaratne
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D002648:Child; D002652:Child Behavior; D003710:Demography; D006306:Health Surveys; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology / Q000523:psychology; D009034:Mother-Child Relations; D009035:Mothers; D009293:Opioid-Related Disorders / Q000453:epidemiology* / Q000523:psychology; D012044:Regression Analysis; D012307:Risk Factors; D012737:Sex Factors