Leptin and leptin receptor expression in a lipoblastoma in an 8-year-old girl.
Leptin is a hormone that is produced by adipocytes. Leptin acts on specific receptors in the hypothalamus. RNA was isolated from a lipoblastoma of an 8-year-old girl and the expression of leptin and leptin receptor mRNA was analyzed by RT-PCR. The lipoblastoma tumor, a rare form of childhood tumors, expressed leptin and leptin receptors in a fashion similar to normal adipose tissue. We hypothesize that the peripheral action of leptin via its receptors could play a role in the development and/or progression of lipoblastoma. Whether or not leptin and leptin receptor expression play a role in the development and/or progression of lipoblastoma and other tumors is not clear to date. Copyrightz1999S.KargerAG, Basel
Deutscher
J
J
Children's Hospital, University of Leipzig, Germany. Deuj@server3.medizin.uni-leipzig.de
Meyer
K
K
Blütters-Sawatzki
R
R
Franke
F E
FE
Kiess
W
W
D017667:Adipocytes / Q000737:chemistry; D002352:Carrier Proteins / Q000235:genetics*; D002648:Child; D005260:Female; D015870:Gene Expression; D006801:Humans; D020738:Leptin / Q000032:analysis / Q000235:genetics*; D008067:Lipoma / Q000737:chemistry* / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D012186:Retroperitoneal Neoplasms / Q000737:chemistry* / Q000473:pathology
D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin