title: Structural bioenergetics and energy transduction mechanisms.
abstract: Life depends on transduction processes that couple cellular metabolism to environmental energy sources such as light or reduced compounds. These primary energy sources must be efficiently converted into forms that can be utilized by cells for biosynthesis, motility, transport, regulation, and other metabolic functions. In recent years, there has been an explosive increase in the determination of structures for proteins mediating energy transduction processes. These developments provide the opportunity to evaluate the structural basis for the efficient coupling of two energetic processes, which defines the area of structural bioenergetics. Here, we present some general features of energy transduction processes, including arguments that effective coupling of two processes by a transduction protein occurs by way of conformational states that are common to the catalysis of each process. This is illustrated by examples from the nucleotide switch family of proteins, with emphasis on the nitrogenase system where ATP hydrolysis is coupled to an electron transfer reaction.
authors.affiliation: Howard Hughes Medical Institute, Division of Chemistry and Chemical Engineering 147-75CH, California Institute of Technology, Pasadena, CA 91125, USA. dcrees@caltech.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Rees
authors.forename: J B
authors.initials: JB
authors.lastname: Howard
mesh_terms: D000818:Animals; D004579:Electron Transport; D004734:Energy Metabolism; D004735:Energy Transfer; D006801:Humans; D007700:Kinetics; D009591:Nitrogenase / Q000737:chemistry / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D009711:Nucleotides; D011506:Proteins; D009591:Nitrogenase