The contribution of ER quality control to the biologic functions of secretory IgM.
Secretory IgM provides a first line of defense against pathogens and is uniquely capable of enhancing the primary humoral immune response. Complement activation is especially important for these activities. Here, Padmalatha Reddy and Ronald Corley discuss how the 'quality control' mechanisms that regulate IgM assembly and secretion play important roles in the developmental progression of B cells and in B-cell function.
Reddy
P S
PS
Dept of Microbiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.
Corley
R B
RB
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003167:Complement Activation; D003545:Cysteine / Q000737:chemistry; D007144:Immunoglobulin J-Chains / Q000737:chemistry / Q000276:immunology; D007075:Immunoglobulin M / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D010950:Plasma Cells / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000172:deficiency / Q000502:physiology; D011960:Receptors, Estrogen / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D011960:Receptors, Estrogen; D013438:Sulfhydryl Compounds; C033027:secretory IgM; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; D003545:Cysteine