title: The german thorotrast study: recent results and assessment of risks.
abstract: The German Thorotrast study comprises 2,326 patients and 1,890 controls. Forty-eight Thorotrast patients and 239 controls are still alive and are invited for a follow-up examination every 2 years. In the deceased patients, the following neoplastic diseases with excess rates were registered (Thorotrast/controls): liver cancer (454/3); cancer of the bile ducts, including gallbladder (42/7); myeloid leukemia (40/7); myelodysplastic syndrome (30/4); plasmacytoma (10/2); non-Hodgkin's lymphoma (15/5); bone sarcoma (4/1); malignant peritoneal or pleural mesothelioma (9/0). Dose calculations are based on results of whole-body counting, X-ray films, and data obtained from the hospital records on the volume of Thorotrast injected. For liver cancer, the cumulative risk estimate was calculated to be 40 per 10(4) person Sv (radiation weighting factor = 20). These figures are close to the results of the Danish study and are comparable to the results of the Life Span Study of A-bomb survivors after 40 years at risk with 18 to 48 liver cancers per 10(4) person Sv. For hematopoietic malignancies, the cumulative risk was calculated to be about 7 per 10(4) person Sv (radiation weighting factor = 20). This risk estimate is lower by a factor of 10 compared to the results of the Life Span Study.
authors.affiliation: Deutsches Krebsforschungszentrum, E0100, D-69120 Heidelberg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
authors.forename: A
authors.initials: A
authors.lastname: Dalheimer
authors.forename: S
authors.initials: S
authors.lastname: Hornik
authors.forename: A
authors.initials: A
authors.lastname: Kaul
authors.forename: D
authors.initials: D
authors.lastname: Liebermann
authors.forename: H
authors.initials: H
authors.lastname: Lührs
authors.forename: A
authors.initials: A
authors.lastname: Spiethoff
authors.forename: K
authors.initials: K
authors.lastname: Wegener
authors.forename: H
authors.initials: H
authors.lastname: Wesch
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000209:etiology; D008113:Liver Neoplasms / Q000209:etiology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011829:Radiation Dosage; D018570:Risk Assessment; D013911:Thorium Dioxide / Q000009:adverse effects*
chemical_list: D013911:Thorium Dioxide