title: [Molecular biology studies of a multicenter phase III study (SIC Study)].
abstract: Transcription factors adjust the up- and downregulation of inflammatory genes. Within the bounds of the SIC-study (Selenium in Intensive Care) the authors will investigate the role of transcription factors NF-kappa B and AP-1 in S.I.R.S/septic patients. The goal of these investigations is the corroboration of therapy of septic patients with sodium selenite at the molecular biological level.
authors.affiliation: Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikums, TU Dresden. zialblcl@rcs.urz.tu-dresden.de
authors.forename: T
authors.initials: T
authors.lastname: Zimmermann
authors.forename: S
authors.initials: S
authors.lastname: Albrecht
authors.forename: G
authors.initials: G
authors.lastname: von Gagern
mesh_terms: D003422:Critical Care; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D016328:NF-kappa B / Q000235:genetics*; D018038:Sodium Selenite / Q000008:administration & dosage* / Q000009:adverse effects; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000235:genetics; D018808:Transcription Factor AP-1 / Q000235:genetics*; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D016328:NF-kappa B; D018808:Transcription Factor AP-1; D018038:Sodium Selenite