title: Recent experience with the arterial switch operation in transposition of the great arteries.
abstract: OBJECTIVE
  Review of our experience with the technically demanding arterial switch operation in transposition of the great arteries in children.
  
  
  METHODS
  Twenty-seven children who underwent an arterial switch operation in our clinic were retrospectively reviewed. Except for one child (operated on at eight months), the operation was performed during the neonatal period. The underlying pathology was d-transposition of the great arteries in 25 children and a double outlet right ventricle of transposition type in 2. Five children had an associated ventricular septum defect and 1 aortic isthmus coarctation. The pattern of the coronary arteries was favourable in 18 children, difficult in 7 and dangerous in 3. The operation was performed in cardiopulmonary bypass for repair of the transposition and in a period of deep hypothermic circulatory arrest for repair of the intracardiac defects.
  
  
  RESULTS
  One child died perioperatively and 1 postoperatively (operative mortality 7%) from myocardial ischaemia following unsuccessful transfer of a dangerous pattern of coronary arteries. Another child, a low-birth weight baby, died 80 days after the operation from respiratory failure. Postoperative morbidity occurred in 10 patients and medium-term morbidity in 6 patients who presented various degrees of stenosis of a pulmonary artery. During a median follow-up of 18 months no patient required reoperation. The children are asymptomatic and thriving satisfactorily.
  
  
  CONCLUSIONS
  Because it restores the heart physiology, the arterial switch operation is considered the procedure of choice for correction of transposition of the great arteries. The operation involves acceptable mortality and morbidity. Transfer of difficult coronary artery patterns and development of stenosis on the pulmonary arteries remain problematic.
authors.affiliation: Klinik für Herz- und Gefässchirurgie, Universitätsspital, Zürich. rene.pretre@chi.usz.ch
authors.forename: R
authors.initials: R
authors.lastname: Prêtre
authors.forename: Q
authors.initials: Q
authors.lastname: Ye
authors.forename: M
authors.initials: M
authors.lastname: Fasnacht
authors.forename: D
authors.initials: D
authors.lastname: Schmidlin
authors.forename: P
authors.initials: P
authors.lastname: Vogt
authors.forename: M
authors.initials: M
authors.lastname: Turina
mesh_terms: D002315:Cardiopulmonary Bypass; D003331:Coronary Vessels / Q000601:surgery*; D004310:Double Outlet Right Ventricle / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate; D014188:Transposition of Great Vessels / Q000150:complications / Q000601:surgery*