Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG.
Global complexity of 47-channel resting electroencephalogram (EEG) of healthy young volunteers was studied after intake of a single dose of a nootropic drug (piracetam, Nootropil UCB Pharma) in 12 healthy volunteers. Four treatment levels were used: 2.4, 4.8, 9.6 g piracetam and placebo. Brain electric activity was assessed through Global Dimensional Complexity and Global Omega-Complexity as quantitative measures of the complexity of the trajectory of multichannel EEG in state space. After oral ingestion (1-1.5 h), both measures showed significant decreases from placebo to 2.4 g piracetam. In addition, Global Dimensional Complexity showed a significant return to placebo values at 9.6 g piracetam. The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.
Kondakor
I
I
The KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.
Michel
C M
CM
Wackermann
J
J
Koenig
T
T
Tanaka
H
H
Peuvot
J
J
Lehmann
D
D
D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects*; D006801:Humans; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage*; D010889:Piracetam / Q000008:administration & dosage*
D018697:Nootropic Agents; D010889:Piracetam