New molecular complexes of heterocyclic bis-adducts with bacterial lectins: synthesis and structure-activity relationship studies.
A strongly antitumour effect has been discovered for lectins of Bacillus bacteria [Bacillus subtilis 668(1 + 2)IMV, Bacillus polymyxa 102(1 + 2) KGU] and for their molecular complexes with some heterocyclic bis-adducts of unsubstituted benzimidazole and 6-methyluracile for the first time. These were tested on the tumours: Lymphosarcoma Plissa, Sarcoma 45, Carcinosarcoma Yokera 256. A new convenient method for the preparation of the heterocyclic bisadducts of imidazole, benzimidazole, uraciles with 1,1,1-trifluoro-2-bromo-2-chloroethane is described. The reactions are catalysed by the 18-crown-6-complex.
Welchinskaya
H V
HV
Institute of Pharmacology and Toxicology, Kiev, Ukraine.
Kuzmenko
I I
II
Kudryavtseva
I G
IG
Sharikina
N I
NI
Kovalenko
E A
EA
Podgorsky
V S
VS
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry*; D001976:Bromouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D037102:Lectins / Q000737:chemistry*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009005:Monosaccharides / Q000737:chemistry; D019158:N-Acetylneuraminic Acid / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
C401662:1,1'(2''-bromo-2''-chloroethenyl)-bis-(5-bromouracil); C401663:1,1'(2''-bromo-2''-chloroethenyl)-bis-(5-nitrouracil); C401664:1,1'(2''-bromo-2'-chloroethenyl)-bis-(5-methyluracile); D000596:Amino Acids; D000970:Antineoplastic Agents; D037102:Lectins; D009005:Monosaccharides; D001976:Bromouracil; D014498:Uracil; D019158:N-Acetylneuraminic Acid