title: Pain relief of oral ulcer by dibucaine-film.
abstract: A water-soluble three-layered oral mucosa-adhesive film made from hydroxypropyl cellulose containing dibucaine (0.25 mg of drug/cm(2)) was designed for alleviation of severe pain due to oral ulcers, caused by chemotherapy and/or radiotherapy. We report two patients with constant severe pain ulcers treated with the dibucaine film. Patients were asked to record the time that pain was relieved while chewing following first application of the film. Pain relief lasted for 2-5 h after application of the dibucaine film.
authors.affiliation: Department of Hospital Pharmacy, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, Nagoya 466, Japan Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya 467, Japan Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, Nagoya 466, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamamura
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Yotsuyanagi
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Okamoto
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nabeshima
mesh_terms: D000269:Adhesives / Q000008:administration & dosage*; D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003992:Dibucaine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects; D019226:Oral Ulcer / Q000188:drug therapy*
chemical_list: D000269:Adhesives; D000779:Anesthetics, Local; D002482:Cellulose; C008079:hydroxypropylcellulose; D003992:Dibucaine