title: Juvenile Parkinson's disease with REM sleep behavior disorder, sleepiness, and daytime REM onset.
abstract: We describe an unmedicated patient with juvenile PD with difficulties maintaining wakefulness and the atonia of REM sleep. Laboratory testing showed enhanced muscle activity in REM sleep consistent with a history of dream enactment behavior (i.e., REM sleep behavior disorder) and daytime sleepiness, and REM-sleep onsets on multiple sleep latency testing. The results emphasize the potential role of dopamine and basal ganglia circuits in the modulation of activated behavioral states (e.g., wakefulness and REM sleep).
authors.affiliation: Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Rye
authors.forename: L H
authors.initials: LH
authors.lastname: Johnston
authors.forename: R L
authors.initials: RL
authors.lastname: Watts
authors.forename: D L
authors.initials: DL
authors.lastname: Bliwise
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D002940:Circadian Rhythm; D003937:Diagnosis, Differential; D004200:Diseases in Twins; D004576:Electromyography; D005260:Female; D005838:Genotype; D006801:Humans; D009290:Narcolepsy / Q000175:diagnosis / Q000235:genetics; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology*; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis / Q000209:etiology*; D012894:Sleep Stages; D012895:Sleep, REM