title: 11-Deoxyfistularin-3, a new cytotoxic metabolite from the caribbean sponge Aplysina fistularis insularis.
abstract: 11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysinafistularis (Aplysinellidae). The structure of 1 was determined by spectroscopic analysis and showed in vitro activity against the human breast carcinoma cell line MCF-7.
authors.affiliation: Centro de Química Orgánica, Escuela de Química Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47102, Caracas, Venezuela.
authors.forename: R S
authors.initials: RS
authors.lastname: Compagnone
authors.forename: R
authors.initials: R
authors.lastname: Avila
authors.forename: A I
authors.initials: AI
authors.lastname: Suárez
authors.forename: O V
authors.initials: OV
authors.lastname: Abrams
authors.forename: H R
authors.initials: HR
authors.lastname: Rangel
authors.forename: F
authors.initials: F
authors.lastname: Arvelo
authors.forename: I C
authors.initials: IC
authors.lastname: Piña
authors.forename: E
authors.initials: E
authors.lastname: Merentes
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C400588:11-Deoxyfistularin-3; D000970:Antineoplastic Agents; D014443:Tyrosine