Distribution of GABAA and glycine receptors in the mammalian retina.
1. GABA and glycine mediate synaptic inhibition via specific neurotransmitter receptors. Molecular cloning studies have shown that there is a great diversity of receptors for these two neurotransmitters. In the present paper, the distribution of GABAA and glycine receptors in the mammalian retina is reviewed. 2. In situ hybridization, immunocytochemistry with subunit-specific antibodies and single cell injection were used to analyse the localization of receptor subunits. Specific subunits are expressed in characteristic strata of the inner plexi-form layer, suggesting that different functional circuits involve specific subtypes of neurotransmitter receptors. 3. Different cell types express different combinations of receptor subunits and an individual neuron can express several receptor isoforms at distinct post-synaptic sites.
Grünert
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Department of Physiology, University of Sydney, New South Wales, Australia. gruenert@physiol.usyd.edu.au
D000818:Animals; D002415:Cats; D003712:Dendrites / Q000737:chemistry; D017950:Ganglia, Sensory / Q000737:chemistry*; D000882:Haplorhini; D007120:Immunochemistry; D017403:In Situ Hybridization; D011817:Rabbits; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis*; D018009:Receptors, Glycine / Q000032:analysis*; D012160:Retina / Q000737:chemistry*
D011963:Receptors, GABA-A; D018009:Receptors, Glycine