title: Development of ocular dominance columns in the absence of retinal input.
abstract: The initial establishment of ocular dominance columns in visual cortex is believed to involve the segregation of overlapping geniculocortical axons into eye-specific patches based on patterns of correlated activity. However, we found that total removal of retinal influence early in visual development did not prevent segregation of geniculocortical axons into alternating stripes with periodicity normal for ocular dominance columns. Because the patterning of geniculocortical afferents resists this dramatic change in the level, source and pattern of spontaneous activity, we propose that formation of ocular dominance columns relies on molecular cues present on thalamic axons, cortical cells or both.
authors.affiliation: Howard Hughes Medical Institute and Department of Neurobiology, Box 3209, Duke University Medical Center, Durham, North Carolina 27710, USA. jcrowley@neuro.duke.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Crowley
authors.forename: L C
authors.initials: LC
authors.lastname: Katz
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology; D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism; D003911:Dextrans / Q000378:metabolism; D005260:Female; D005289:Ferrets; D005456:Fluorescent Dyes / Q000378:metabolism; D005829:Geniculate Bodies / Q000166:cytology / Q000254:growth & development / Q000502:physiology; D008297:Male; D008863:Microspheres; D009475:Neurons, Afferent / Q000502:physiology; D012160:Retina / Q000502:physiology* / Q000601:surgery; D012683:Sensory Deprivation / Q000502:physiology*; D013997:Time Factors; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology*; D014795:Visual Pathways / Q000254:growth & development* / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
chemical_list: D003911:Dextrans; D005456:Fluorescent Dyes; C076397:biotinylated dextran amine; D001710:Biotin