title: Immunological markers of frequently recurrent genital herpes simplex virus and their response to hypnotherapy: a pilot study.
abstract: Patients were recruited for hypnotherapy from a clinic for patients with frequently recurrent genital herpes simplex virus (rgHSV). Psychological and immunological parameters were measured 6 weeks prior to hypnotherapy and 6 weeks afterwards, during which time each patient kept a diary of symptoms of rgHSV. Following hypnotherapy there was a significant overall reduction in the number of reported episodes of rgHSV, accompanied by an increase in the numbers of CD3 and CD8 lymphocytes, which may represent a non specific effect of hypnosis. The improvers showed significant rises in natural killer (NK) cell counts, HSV specific lymphokine activated killer (LAK) activity, and reduced levels of anxiety when compared to non-improvers. NK cell numbers and HSV specific LAK activity may therefore be important in the reduction in rgHSV following hypnotherapy.
authors.affiliation: Department of HIV and Genitourinary Medicine, Chelsea & Westminster Hospital, London, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Fox
authors.forename: D C
authors.initials: DC
authors.lastname: Henderson
authors.forename: S E
authors.initials: SE
authors.lastname: Barton
authors.forename: A J
authors.initials: AJ
authors.lastname: Champion
authors.forename: M S
authors.initials: MS
authors.lastname: Rollin
authors.forename: J
authors.initials: J
authors.lastname: Catalan
authors.forename: S M
authors.initials: SM
authors.lastname: McCormack
authors.forename: J
authors.initials: J
authors.lastname: Gruzelier
mesh_terms: D000328:Adult; D015415:Biomarkers; D017252:CD3 Complex / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology* / Q000523:psychology / Q000628:therapy*; D006801:Humans; D006990:Hypnosis; D007694:Killer Cells, Natural; D018655:Lymphocyte Count; D008297:Male; D010865:Pilot Projects; D012008:Recurrence
chemical_list: D015415:Biomarkers; D017252:CD3 Complex