A new approach to the synthesis of efaroxan.
Efaroxan was synthetised by cyclisation of the tertiary alcohol 2 which was prepared by the ring opening of the gem-disubstituted epoxide 3 with ortho-metallated fluorobenzene.
Couture
K
K
Laboratoire de Synthèse Bio-Organique, CNRS et Université Louis Pasteur, Faculté de Pharmacie 74, Illkirch-Graffenstaden, France.
Gouverneur
V
V
Mioskowski
C
C
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis*
D000317:Adrenergic alpha-Antagonists; D001572:Benzofurans; D004852:Epoxy Compounds; D007093:Imidazoles; C062597:efaroxan