No additional effect of calcipotriol ointment on low-dose narrow-band UVB phototherapy in psoriasis.
BACKGROUND
Broad-band UVB phototherapy has appeared to be effective in clearing psoriatic lesions. After the advent of calcipotriol ointment, promising results have been obtained by combining these two therapeutic modalities. Also, an additional effect of narrow-band UVB phototherapy on treatment with calcipotriol ointment has been demonstrated.


OBJECTIVE
Our purpose was to compare treatment with low-dose narrow-band UVB phototherapy both with and without calcipotriol ointment.


METHODS
We included 53 patients suffering from plaque-type psoriasis. All patients underwent low-dose narrow-band UVB phototherapy. Nearly half of the patients were randomized to apply calcipotriol ointment (50 microg/g) twice daily on the affected skin. The Psoriasis Area and Severity Index (PASI) was used to evaluate psoriatic lesions.


RESULTS
In this study we showed that low-dose narrow-band UVB phototherapy is effective in the treatment of psoriasis and that calcipotriol ointment does not improve treatment outcome.


CONCLUSIONS
Calcipotriol ointment does not improve treatment with low-dose narrow-band UVB phototherapy.
Brands
S
S
Department of Dermatology, Academic Medical Centre, University of Amsterdam, and the Department of Dermatology, Reinier de Graaf Gasthuis, Delft, The Netherlands.
Brakman
M
M
Bos
J D
JD
de Rie
M A
MA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010789:Phototherapy / Q000379:methods; D011565:Psoriasis / Q000188:drug therapy / Q000628:therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol