[Hypoglycemia as a risk factor in embryonic development in maternal diabetes mellitus. Review of the literature].
Hypoglucemia, or decrease in normal blood glucose concentration, is an important sequel of tight control of type 1 diabetic patients. In pregnant diabetic women, hypoclycemia does not appears affect the embryo or fetal development; while in rodent, it is an important cause of teratogenesis and/or embryotoxicity, when it is presented during organogenesis. Despite metabolic, endocrine and temporal differences between human and rodent pregnancy, a possible damage to the product, caused by hypoblycemia during pregnancy in human, must be considered.
Palomar-Morales
M
M
Laboratorio de Biología del Desarrollo, UNAM Campus Iztacala, Estado de México.
Méndez
J D
JD
D000818:Animals; D000013:Congenital Abnormalities / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D007003:Hypoglycemia / Q000150:complications / Q000209:etiology*; D007226:Infant Mortality; D007231:Infant, Newborn; D008428:Maternal Mortality; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011270:Pregnancy, Animal; D012307:Risk Factors; D012377:Rodentia