title: Dinucleotide repeat polymorphisms within the Flt-1 gene in minimal change nephropathy.
abstract: Dysregulation of Flt-1, a major receptor for vascular permeability factor (VPF), may provide a mechanism for the development of proteinuria in minimal change nephropathy (MCN). The gene for Flt-1 has a polymorphic dinucleotide repeat. We have demonstrated an 88% predominance of one allele and an 80% rate of homozygosity for this polymorphism with no association with MCN.
authors.affiliation: Academic Renal Unit, Southmead Hospital, Bristol, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Parry
authors.forename: K M
authors.initials: KM
authors.lastname: Gillespie
authors.forename: A G
authors.initials: AG
authors.lastname: Clark
authors.forename: P W
authors.initials: PW
authors.lastname: Mathieson
mesh_terms: D044383:Black People / Q000235:genetics; D018900:Dinucleotide Repeats; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D009402:Nephrosis, Lipoid / Q000235:genetics*; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012016:Reference Values; D040281:Vascular Endothelial Growth Factor Receptor-1; D044465:White People / Q000235:genetics
chemical_list: D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D040281:Vascular Endothelial Growth Factor Receptor-1