title: [Abdominal scintigraphy with 99MTc-HMPAO-labelled leukocytes. Utility of the quantification in the evaluation of the inflammatory activity of Crohn's disease and ulcerative colitis].
abstract: We aimed to determine the activity of Crohn's Disease (CD) and Ulcerative Colitis (UC) with this radiotracer and to compare it with the normal clinical indexes. 32 patients with CD (19 women) and 18 with UC (13 women) were studied and a sequential abdominal 99mTc-HMPAO-label leukocyte scintigraphy was performed after evaluating the activity clinical scales indexes (Harvey's for CD and Lictiger for UC). Quantification was performed to obtain intestinal activity indexes in regards to intestinal uptake with background, bone marrow, liver and spleen, comparing them with the clinical indexes. In CD, all scintigraphic indexes showed a significant correlation (p < 0.001) with clinical activity. The best results were obtained with gut/background (r: 0.73) and gut/bone marrow (r: 0.72). In UC, we obtain a lower correlation between clinical and scintigraphic indexes. Significant correlations (p < 0.05) were only found with the gut/background (r: 0.52) and gut/bone marrow growth indexes (r: 0.58). The others showed no correlation. In conclusion, IBD activity estimated with 99mTc-WBC and scintigraphy indexes showed moderate correlation with clinical scales. However, the information of the scintigraphy was very useful in the management of these patients.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario San Juan de Alicante, Alicante, 03550, España. jserrano@san.gva.es
authors.forename: J
authors.initials: J
authors.lastname: Serrano
authors.forename: A
authors.initials: A
authors.lastname: Gómez
authors.forename: J
authors.initials: J
authors.lastname: Verdú
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: M
authors.initials: M
authors.lastname: Antón
authors.forename: E
authors.initials: E
authors.lastname: Griñó
authors.forename: R
authors.initials: R
authors.lastname: Jover
authors.forename: O
authors.initials: O
authors.lastname: Caballero
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging*; D003424:Crohn Disease / Q000000981:diagnostic imaging*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007249:Inflammation; D007422:Intestines / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime