Determination of in vivo rat muscle Gd-DTPA relaxivity at 6.3 T.
For the in vivo relaxivity of Gd-DTPA at 6.3 T in rat muscle a value of 2.7+/-0.5 (mM s)(-1) was found, and for the in vitro value in water 3.00+/-0.56 (mM s)(-1) at 37 degrees C. The temperature dependence of the in vitro relaxivity was -0.087 (mM s degrees C)(-1). The relation between 1/T1 and the tissue Gd-DTPA concentration is linear for the normally used in vivo Gd-DTPA concentration range.
Rozijn
T H
TH
Department of Applied Physics, Delft University of Technology, The Netherlands.
van der Sanden
B P
BP
Heerschap
A
A
Creyghton
J H
JH
Boveé
W M
WM
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005069:Evaluation Studies as Topic; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D003287:Contrast Media; D019786:Gadolinium DTPA