title: Relative avidities of human immunoglobulin G antibodies for streptococcal pyrogenic exotoxins A and B.
abstract: In this pilot study, we investigated the relative avidities for streptococcal pyrogenic exotoxin A (SPE-A) and SPE-B of antibodies in sera from patients with fatal streptococcal toxic shock-like syndrome and from healthy individuals and in intravenous immunoglobulin (IVIG) preparations. We observed a great variation in the relative avidities of patient, control, and IVIG immunoglobulin G (IgG) (values estimated to be between 10(-7) and 10(-11) M), with mean values for patient IgG about 10-fold lower than those of control IgG.
authors.affiliation: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center, Utrecht, The Netherlands. e.m.mascini@lab.azu.nl
authors.forename: E M
authors.initials: EM
authors.lastname: Mascini
authors.forename: M
authors.initials: M
authors.lastname: Jansze
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: H
authors.initials: H
authors.lastname: van Dijk
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D000915:Antibody Affinity / Q000276:immunology*; D001426:Bacterial Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D005098:Exotoxins / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D016756:Immunoglobulins, Intravenous; D008565:Membrane Proteins; D008875:Middle Aged; D010865:Pilot Projects; D013290:Streptococcal Infections / Q000276:immunology* / Q000628:therapy; D013297:Streptococcus pyogenes / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D005098:Exotoxins; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D008565:Membrane Proteins; C117980:SpeA protein, Streptococcus pyogenes; C027951:erythrogenic toxin