Hepatitis from 5-methoxypsoralen occurring in a patient with previous flucloxacillin hepatitis.
A 55-year-old woman with psoriasis vulgaris was treated with oral 5-methoxypsoralen and UVA photochemotherapy. After 40 treatments over 3 months she became unwell with hepatitis attributable to the psoralen. Six years earlier she developed cholestatic hepatitis to flucloxacillin. A previous history of drug-induced reactions should be sought before prescribing further drugs with similar adverse effects.
Stephens
R B
RB
Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Cooper
A
A
D000078223:5-Methoxypsoralen; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D005436:Floxacillin / Q000009:adverse effects; D006801:Humans; D008730:Methoxsalen / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D010406:Penicillins / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*
D010406:Penicillins; D005436:Floxacillin; D000078223:5-Methoxypsoralen; D008730:Methoxsalen