Expression of thrombomodulin, caveolin-3, and desmin on muscle fibers in neuromuscular diseases.
The expression of thrombomodulin (TM) and caveolin-3 on biopsied muscle fibers from 17 patients with various neuromuscular diseases was studied immunocytochemically. We also compared the expression of TM and caveolin-3 with that of desmin, which is a marker for muscle fiber regeneration. Most TM-positive muscle fibers strongly expressed caveolin-3 and desmin. Our results suggest that TM is expressed and caveolin-3 is upregulated during the process of muscle fiber regeneration.
Niiyama
T
T
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Higuchi
I
I
Maruyama
I
I
Osame
M
M
D015415:Biomarkers; D051244:Caveolin 3; D022461:Caveolins; D003893:Desmin / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000096:biosynthesis*; D018485:Muscle Fibers, Skeletal / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D009124:Muscle Proteins / Q000096:biosynthesis*; D009468:Neuromuscular Diseases / Q000378:metabolism* / Q000473:pathology; D012038:Regeneration / Q000502:physiology; D018180:Thrombomodulin / Q000096:biosynthesis*
D015415:Biomarkers; D051244:Caveolin 3; D022461:Caveolins; D003893:Desmin; D008565:Membrane Proteins; D009124:Muscle Proteins; D018180:Thrombomodulin