Correlation of lipid peroxidation and alpha-tocopherol supplementation in patients with cervical carcinoma, receiving radical radiotherapy.
Vitamin E acts as antipromoter of carcinogenesis and MDA is a byproduct of lipid peroxidation inherent in carcinogenesis. Reduced serum levels of vitamin E have been found to be associated with higher risk of oral, gastrointestinal and breast cancers. This study was designed to evaluate status of serum vitamin E levels in carcinoma cervix patients receiving radical radiotherapy (RRT).


METHODS
Fifty patients with biopsy-proven carcinoma of the cervix were divided into two groups. Group I received vitamin E supplement (100 mg orally daily) in addition to RRT. Group II received RRT only. Serum vitamin E and MDA levels were compared in the two groups pre- and post-RRT using Duggans and Beuges methods, respectively. RESULTS AND CONCLUSIONS Serum vitamin E levels were statistically lower in 50 patients than in controls. Post-RRT serum vitamin E levels increased in group I (p < 0.02) and group II (p < 0. 01) while serum MDA levels decreased in group I (p < 0.01) and group II (p < 0.05) meaning thereby that oxidative stress and consequent lipid peroxidation was reduced with decrease in tumour mass. Mean post-RRT serum vitamin E levels in the two groups was not statistically different. We found that serum vitamin E levels in the patients did not correlate with oral supplementation of vitamin E.
Gitanjali
G
G
Departments of Biochemistry and Radiation Oncology, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Ghalaut
V
V
Rakshak
M
M
Hooda
H S
HS
D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*
D014810:Vitamin E; D008315:Malondialdehyde