title: Coexistence of morphea and psoriasis responding to acitretin treatment.
abstract: A large number of dermatoses associated with either morphea and psoriasis have been reported. However, to the best of our knowledge there is only one report in the literature about coexistence of morphea and psoriasis. Here we report a case of morphea and psoriasis that improved with acitretin treatment. The concomitant occurrence of these two dermatoses may be explained by immunological factors or trauma. We think that the improvement of the morphea lesions may be due to an immunomodulatory effect of the drug or a decrease in collagen production by dermal fibroblasts due to retinoic acid.
authors.affiliation: Department of Dermatology, Kocaeli University, Faculty of Medicine, Izmit, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Bilen
authors.forename: R
authors.initials: R
authors.lastname: Apaydin
authors.forename: C
authors.initials: C
authors.lastname: Erçin
authors.forename: G
authors.initials: G
authors.lastname: Harova
authors.forename: F
authors.initials: F
authors.lastname: Başdaş
authors.forename: D
authors.initials: D
authors.lastname: Bayramgürler
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D003094:Collagen / Q000032:analysis; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012594:Scleroderma, Localized / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D003094:Collagen; D017255:Acitretin