title: Immunologic aspect of testicular torsion: detection of antisperm antibodies in contralateral testicle.
abstract: OBJECTIVE
  To evaluate the immunologic etiology in unilateral testicular torsion, an experimental study in rats was carried out.
  
  
  METHODS
  75 adult Wistar rats included in the study program were divided into six different groups according to a torsion-detorsion procedure. Torsion degree was kept constant for all animals (720 degrees ). Anti-rat immunoglobulin G (IgG) antibodies against spermatozoa antigens were identified in contralateral testicular tissue after 1 month following detorsion and/or orchiectomy of the twisted testicle.
  
  
  RESULTS
  We revealed antibody formation in animals subjected to unilateral torsion for 12 and 24 h, which then followed by detorsion of the testicle. IgG was identified especially on basal membrane of the tubules.
  
  
  CONCLUSIONS
  As the controversy on the exact mechanism of testicular damage in unilateral torsion still continues, our findings showed that a possible immunological etiology may play an important role in this respect.
authors.affiliation: Department of Urology, University of Süleyman Demirel, Medical School, Isparta, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Koşar
authors.forename: B
authors.initials: B
authors.lastname: Küpeli
authors.forename: G
authors.initials: G
authors.lastname: Alçigir
authors.forename: H
authors.initials: H
authors.lastname: Ataoglu
authors.forename: K
authors.initials: K
authors.lastname: Sarica
authors.forename: S
authors.initials: S
authors.lastname: Küpeli
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013086:Spermatic Cord Torsion / Q000276:immunology* / Q000473:pathology; D013091:Spermatogenesis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A