[Aseptic meningitis induced by high-dose gamma-globulin in an adult woman with antiphospholipid syndrome and chronic idiopathic thrombocytopenic purpura].
It is well known that the administration of high-dose gamma-globulin concentrate is effective in alleviating thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). However, treatment can sometimes induce aseptic meningitis. A 25-year-old Japanese woman with antiphospholipid syndrome and ITP was conditioned with high-dose gamma-globulin concentrate prior to splenectomy. Three days after the initial gamma-globulin course, she experienced severe headache, vomiting, and high-grade fever. Cerebrospinal fluid examination yielded a diagnosis of aseptic meningitis. The patient's clinical symptoms and abnormal cerebrospinal fluid findings disappeared immediately after the discontinuation of gamma-globulin therapy. Cases of aseptic meningitis induced by high-dose gamma-globulin therapy are uncommon in the literature, and most involve children. Moreover, to our knowledge, only 1 Japanese adult ITP case of gamma-globulin-induced aseptic meningitis has been reported to date. Aseptic meningitis may be one of the important adverse effects of the administration of high-dose gamma-globulin concentrate to pediatric as well as adult ITP patients.
Yamazaki
M
M
Department of Internal Medicine (III), Kanazawa University School of Medicine.
Mizutani
T
T
Kato
M
M
Ontachi
Y
Y
Saito
M
M
Morishita
E
E
Asakura
H
H
Matsuda
T
T
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008582:Meningitis, Aseptic / Q000209:etiology*; D011300:Preoperative Care; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D013156:Splenectomy; D005719:gamma-Globulins / Q000008:administration & dosage / Q000009:adverse effects*
D005719:gamma-Globulins