Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia.
The effects of bovine cerebral cortex phosphatidylserine (BCPS) on the memory impairment induced by scopolamine in mice tested in the plus-maze discriminative avoidance task were investigated. Swiss male mice received daily i.p. 50 mg/kg BCPS or 0.2 M Tris pH 7.4 (TRIS) for 5 days. Twenty-four hours after the last injection, the animals received 1 mg/kg scopolamine (BCPS-SCO and TRIS-SCO) or saline (BCPS-SAL and TRIS-SAL) i.p. After 20 min, the animals were submitted to discriminative avoidance conditioning. In the test, performed 24 h later, BCPS-SCO, BCPS-SAL, and TRIS-SAL (but not TRIS-SCO) mice spent significantly less time in the aversive enclosed arm of the discriminative avoidance apparatus when compared to the time spent in the nonaversive enclosed arm. The results suggest that BCPS attenuates scopolamine-induced amnesia in a discriminative avoidance task.
Claro
F T
FT
Departamento de Farmacologia, Escola Paulista de Medicine-UNIFESP, São Paulo, Brazil.
Silva
R H
RH
Frussa-Filho
R
R
D000647:Amnesia / Q000139:chemically induced* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004192:Discrimination, Psychological / Q000187:drug effects / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000378:metabolism / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D018727:Muscarinic Antagonists; D010718:Phosphatidylserines; D012601:Scopolamine