ABO antigen blood-group compatibility and allograft rejection in corneal transplantation.
OBJECTIVE
To evaluate effects of ABO antigen blood-group matching on the rates of corneal allograft rejection after penetrating keratoplasty.


METHODS
We retrospectively studied clinical results of penetrating keratoplasties in terms of graft survival rates and rejection-free graft survival rates. Penetrating keratoplasties were done on 95 eyes between 1993 and 1997. Clinical results were analyzed using the Kaplan-Meier life table method and log-rank test. The corneal transplantations were classified into 2 groups, high-risk (35 eyes) and low-risk (60 eyes) transplantations. High-risk transplantation was defined as significant vascularization in the recipient corneas or a history of graft failure. The remaining transplantations were defined as low-risk.


RESULTS
The respective graft survival (p = 0.031) and rejection-free graft survival (p = 0.0097) rates were higher in the low-risk than in the high-risk group. In the high-risk group, the rejection-free graft survival was 68.9% for the ABO-compatible subgroup and 36.4% for the ABO-incompatible subgroup (p = 0.007).


CONCLUSIONS
ABO matching is effective in reducing the risk of allograft rejection in high-risk corneal transplantations.
Inoue
K
K
Department of Ophthalmology, Branch Hospital, Faculty of Medicine, University of Tokyo, Japan. inoue-k@fd5.so-net.ne.jp
Tsuru
T
T
D000017:ABO Blood-Group System / Q000276:immunology*; D016039:Corneal Transplantation; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006085:Graft Survival; D006648:Histocompatibility; D006801:Humans; D015993:Life Tables; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System