title: The short-term effect of spinal manipulation in the treatment of infantile colic: a randomized controlled clinical trial with a blinded observer.
abstract: OBJECTIVE
  To determine whether there is a short-term effect of spinal manipulation in the treatment of infantile colic.
  
  
  METHODS
  A randomized controlled trial.
  
  
  METHODS
  A private chiropractic practice and the National Health Service's health visitor nurses in the suburb Ballerup (Copenhagen, Denmark).
  
  
  METHODS
  Infants seen by the health visitor nurses, who fulfilled the diagnostic criteria for infantile colic.
  
  
  METHODS
  One group received spinal manipulation for 2 weeks, the other was treated with the drug dimethicone for 2 weeks.
  
  
  METHODS
  Changes in daily hours of crying as registered in a colic diary.
  
  
  RESULTS
  By trial days 4 to 7, hours of crying were reduced by 1 hour in the dimethicone group compared with 2.4 hours in the manipulation group (P = .04). On days 8 through 11, crying was reduced by 1 hour for the dimethicone group, whereas crying in the manipulation group was reduced by 2.7 hours (P = .004). From trial day 5 onward the manipulation group did significantly better that the dimethicone group.
  
  
  CONCLUSIONS
  Spinal manipulation is effective in relieving infantile colic.
authors.affiliation: Center for Biomechanics, Odense University, Denmark.
authors.forename: J M
authors.initials: JM
authors.lastname: Wiberg
authors.forename: J
authors.initials: J
authors.lastname: Nordsteen
authors.forename: N
authors.initials: N
authors.lastname: Nilsson
mesh_terms: D001724:Birth Weight; D003085:Colic / Q000188:drug therapy / Q000628:therapy*; D003448:Crying; D003718:Denmark; D004643:Emollients / Q000627:therapeutic use*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020393:Manipulation, Spinal; D008423:Maternal Age; D012841:Simethicone / Q000627:therapeutic use*; D016037:Single-Blind Method; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D004643:Emollients; D012841:Simethicone