title: Regeneration of the mammalian central vestibular pathway using the rat as animal model.
abstract: Regeneration of the mammalian central vestibular system was examined in rat. The lateral vestibulospinal tract (LVST) of infant rat was transected unilaterally at the level of C1-3. After a postoperative interval of several weeks, the LVST was examined by injecting an anterograde tracer (wheat germ agglutinin-conjugated horseradish peroxidase) into the lateral vestibular nucleus (LVN) and a retrograde tracer (Fast Blue) into the lumbar enlargement. More than half of the rats showed successful regeneration, indicating definite plasticity in the mammalian central vestibular system.
authors.affiliation: Department of Otolaryngology, Otsu Red Cross Hospital, 1-1-35 Nagara, Otsu 520-0046, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Kawaguchi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology* / Q000601:surgery*; D014725:Vestibular Nerve / Q000502:physiology* / Q000601:surgery*