title: Functional visual loss in amblyopia and the effect of occlusion therapy.
abstract: OBJECTIVE
  The aim of this study was to define the nature of functional visual loss in amblyopia and to identify those subjects whose amblyopia is chiefly due to one or more of the following deficits: abnormal contour interaction, abnormal eye movements, abnormal contrast perception, or positional uncertainty.
  
  
  METHODS
  Fifty amblyopic children with a mean age of 5.6+/-1.3 years were referred from diverse sources. In addition to routine orthoptic and optometric evaluation the principal visual deficits in the amblyopic eye of each subject were identified using the following measures of visual acuity: high contrast linear, single optotype, repeat letter and low contrast linear, plus Vernier and displacement thresholds. These measures were repeated as the children underwent a prescribed occlusion therapy regime, after parental consent.
  
  
  RESULTS
  All amblyopic subjects demonstrated a functional loss in each of the tests used, and occlusion therapy appeared to improve all aspects of the amblyopia. High contrast visual acuity was not always the primary deficit in visual function, and when amblyopic subjects were divided according to their primary visual loss, this visual function was found to show the greatest improvement with treatment.
  
  
  CONCLUSIONS
  These results suggest that to successfully identify the primary visual deficit and monitor the success of occlusion therapy it is necessary to assess other aspects of visual function in amblyopia.
authors.affiliation: Department of Psychology, University of Essex, Wivenhoe Park, Colchester, UK. anitas@essex.ac.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Simmers
authors.forename: L S
authors.initials: LS
authors.lastname: Gray
authors.forename: P V
authors.initials: PV
authors.lastname: McGraw
authors.forename: B
authors.initials: B
authors.lastname: Winn
mesh_terms: D000550:Amblyopia / Q000503:physiopathology* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D015350:Contrast Sensitivity / Q000502:physiology; D005139:Eyeglasses; D006801:Humans; D012683:Sensory Deprivation; D012684:Sensory Thresholds; D014786:Vision Disorders / Q000503:physiopathology*; D014787:Vision Tests; D014792:Visual Acuity / Q000502:physiology