Role of keratinocyte injury in adherence of Streptococcus pyogenes.
Keratinocytes injured acutely by UVB light or lipopolysaccharide were used to test the hypothesis that keratinocyte injury promotes bacterial adherence and the development of group A streptococcal skin infections. Injury did not affect adherence to undifferentiated and differentiated keratinocytes, but keratinocyte differentiation promoted adherence four- to fivefold.
Darmstadt
G L
GL
Divisions of Infectious Diseases, Department of Pediatrics, Children's Hospital & Regional Medical Center, Seattle, Washington 98105, USA.
Mentele
L
L
Fleckman
P
P
Rubens
C E
CE
D001422:Bacterial Adhesion; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000382:microbiology* / Q000528:radiation effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D013297:Streptococcus pyogenes / Q000502:physiology*; D014466:Ultraviolet Rays
D008070:Lipopolysaccharides