[P53-status of cells from patients with progeria and ataxia-telangiectasia exposed to ionizing irradiation].
P53 protein expression and stabilization in cell strains derived from patients suffering from progeria and ataxia-telangiectasia following gamma-irradiation have been described. A similar pattern of P53-status in healthy donor and progeria patient cells was shown using immunofluorescent cell staining. In ataxia-telangiectasia cells (strain AT2SP) the P53 protein was not detected by the same method. These data well compare with literary evidence on a disturbed P53-status at ataxia-telangiectasia.
Smirnova
N V
NV
Institute of Cytology, Russian Academy of the Sciences, St. Petersburg. smirnova@link.cytspb.rssi.ru
Spivak
I M
IM
Mikhel'son
V M
VM
D000328:Adult; D001260:Ataxia Telangiectasia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005260:Female; D005347:Fibroblasts / Q000378:metabolism* / Q000528:radiation effects*; D006801:Humans; D008297:Male; D011371:Progeria / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53