title: Klinefelter's syndrome accompanied by mixed connective tissue disease and diabetes mellitus.
abstract: We report a rare case of Klinefelter's syndrome (KS) with mixed connective tissue disease (MCTD), diabetes mellitus (DM) and several endocrine disorders. A 57-year-old man presented with polyarthritis and tapering fingers with Raynaud's phenomenon on admission. In addition to a karyotype of 47, XXY, a marked restrictive change in respiratory functional test, a myogenic pattern in electromyogram, the positive tests for anti-RNP antibody indicated that this was a case of KS complicated with MCTD. The patients also presented DM with insulin resistance, hyperprolactinemia, slight primary hypothyroidism and hypoadrenocorticism. The mechanism for these coincidences remains to be elucidated.
authors.affiliation: Department of Internal Medicine, Nagoya National Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: J
authors.initials: J
authors.lastname: Sintani
authors.forename: H
authors.initials: H
authors.lastname: Masukawa
authors.forename: R
authors.initials: R
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Oi
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Niinomi
mesh_terms: D001168:Arthritis / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004700:Endocrine System Diseases / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007713:Klinefelter Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications*; D010375:Pedigree