title: Role of keratinocyte injury in adherence of Streptococcus pyogenes.
abstract: Keratinocytes injured acutely by UVB light or lipopolysaccharide were used to test the hypothesis that keratinocyte injury promotes bacterial adherence and the development of group A streptococcal skin infections. Injury did not affect adherence to undifferentiated and differentiated keratinocytes, but keratinocyte differentiation promoted adherence four- to fivefold.
authors.affiliation: Divisions of Infectious Diseases, Department of Pediatrics, Children's Hospital & Regional Medical Center, Seattle, Washington 98105, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Darmstadt
authors.forename: L
authors.initials: L
authors.lastname: Mentele
authors.forename: P
authors.initials: P
authors.lastname: Fleckman
authors.forename: C E
authors.initials: CE
authors.lastname: Rubens
mesh_terms: D001422:Bacterial Adhesion; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000382:microbiology* / Q000528:radiation effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D013297:Streptococcus pyogenes / Q000502:physiology*; D014466:Ultraviolet Rays
chemical_list: D008070:Lipopolysaccharides