Isolation and structure elucidation of two new flavonoid glycosides from the infusion of maytenus aquifolium leaves. Evaluation of the antiulcer activity of the infusion.
Droplet countercurrent chromatography and high-performance liquid chromatography fractionation of the aqueous infusion from Maytenus aquifolium Martius leaves afforded two flavonoid tetrasaccharides: quercetin 3-O-alpha-L-rhamnopyranosyl(1-->6)-O-[beta-D-glucopyranosyl(1-->3)-O- alpha-L-rhamnopyranosyl(1-->2)-O-beta-D-galactopyranoside and kaempferol 3-O-alpha-L-rhamnopyranosyl(1-->6)-O-[beta-D-glucopyranosyl(1-->3)-O- alpha-L-rhamnopyranosyl(1-->2)-O-beta-D-galactopyranoside. All structures were elucidated by spectroscopic methods. Pharmacological essays of the infusion showed antiulcer activity in rats.
Vilegas
W
W
Instituto de Quimica de Araraquara, Universidade Estadual Paulista, Araraquara, SP, Brazil.
Sanommiya
M
M
Rastrelli
L
L
Pizza
C
C
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D044949:Kaempferols; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control; D013315:Stress, Psychological / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D005419:Flavonoids; D044949:Kaempferols; D009844:Oligosaccharides; C412884:kaempferol 3-O-rhamnopyranosyl-1-6-O-(glucopyranosyl-1-3-O-rhamnopyranosyl-1-2)-O-galactopyranoside; C412883:quercetin 3-O-rhamnopyranosyl-1-6-O-(glucopyranosyl-1-3-O-rhamnopyranosyl-1-2)-O-galactopyranoside; D011794:Quercetin