The regulatory role of leptin in food intake.
This review discusses recent work that has focused on the interaction of leptin with various neuroendocrine pathways in the brain and in the periphery to affect food intake. Additional consideration is directed towards emerging studies with antibodies and receptor antagonists that show leptin has a physiologically important role in the control of food intake.
Brunner
L
L
Department of Metabolic and Cardiovascular Diseases, Novartis Pharma AG, Basel, Switzerland.
Levens
N
N
D000818:Animals; D002766:Cholecystokinin / Q000378:metabolism; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D004435:Eating / Q000502:physiology*; D005934:Glucagon / Q000378:metabolism; D052216:Glucagon-Like Peptide 1; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009478:Neuropeptide Y / Q000378:metabolism; D009490:Neurosecretory Systems / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D020738:Leptin; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D010446:Peptide Fragments; D011498:Protein Precursors; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D011333:Pro-Opiomelanocortin; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D002766:Cholecystokinin; D003346:Corticotropin-Releasing Hormone