Immunohistochemistry applied to the study of bone marrow Gaucher's cells: a case report.
Gaucher's disease is frequently associated with immunologic abnormalities, e.g. hypergammaglobulinemia, polyclonal gammopathy and benign monoclonal gammopathy. A patient with Gaucher's disease and a selective accumulation of IgM k in Gaucher's cells without serum monoclonal gammopathies is described. The selective accumulation is detected by immunohistochemistry analysis performed on cryostat bone marrow biopsies.
Alterini
R
R
Department of Haematology, University of Florence, Italy.
Rigacci
L
L
Stefanacci
S
S
Innocenti
F
F
Santini
V
V
Carrai
V
V
Rossi Ferrini
P
P
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001854:Bone Marrow Cells / Q000276:immunology* / Q000473:pathology*; D001856:Bone Marrow Examination; D005260:Female; D005776:Gaucher Disease / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007150:Immunohistochemistry
D015703:Antigens, CD; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains