An anatomical landmark for the supplementary eye fields in human revealed with functional magnetic resonance imaging.
Together with the frontal and parietal eye fields, the supplementary eye field (SEF) is involved in the performance and control of voluntary and reflexive saccades and of ocular pursuit. This region was first described in non-human primates and is rather well localized on the dorsal surface of the medial frontal cortex. In humans the site of the SEF is still ill-defined. Functional imaging techniques have allowed investigation of the location and function of the SEF. However, there is great variability with regard to the published standardized coordinates of this area. We used here the spatial precision of functional magnetic resonance imaging (fMRI) in order to better localize the SEF in individuals. We identified as the SEF a region on the medial wall that was significantly activated when subjects executed self-paced horizontal saccades in darkness as compared to rest. This region appeared to be predominantly activated in the left hemisphere. We found that, despite a discrepancy of >2 cm found in the standardized Talairach coordinates, the location of this SEF-region could be precisely and reliably described by referring to a sulcal landmark found in each individual: the upper part of the paracentral sulcus.
Grosbras
M H
MH
LPPA, Collège de France, Paris.
Lobel
E
E
Van de Moortele
P F
PF
LeBihan
D
D
Berthoz
A
A
D000328:Adult; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004585:Electrooculography; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012438:Saccades / Q000502:physiology*; D013238:Stereotaxic Techniques