Effect of theophylline on the warm-up phenomenon.
This study examined whether the adenosine receptor antagonist theophylline prevents the warm-up phenomenon in patients with stable angina undergoing serial exercise tests. Our findings offer evidence that adenosine does not play a role in the warm-up phenomenon, and indirectly suggest that the warm-up phenomenon does not represent ischemic preconditioning in humans.
Kerensky
R A
RA
Division of Cardiovascular Medicine, University of Florida, Shands at the University of Florida, Gainesville 32610-0277, USA.
Franco
E
E
Schlaifer
J D
JD
Pepine
C J
CJ
Belardinelli
L
L
D000241:Adenosine / Q000502:physiology*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology*; D017023:Coronary Angiography / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D008875:Middle Aged; D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline / Q000494:pharmacology*
D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline; D000241:Adenosine