[Statistical analysis of the exon-intron structure of higher eukaryote genes].
The exon-intron structure of human, insect (Drosophila sp.), and dicot plant (Arabidopsis thaliana) genes was considered. In each genome there exists a characteristic intron length. Anomalously long introns was usually the first introns in genes. In each sample there are correlations between the lengths of neighboring exons and between exon lengths and closeness to the consensus of the sites at exon boundaries. Exons and exon pairs containing an integer number of triplets are preferred. These results are relevant to the study of splicing mechanism and evolution of introns, as well as construction of gene recognition algorithms.
Kriventseva
E V
EV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Makeev
V Iu
VIu
Gel'fand
M S
MS
D000465:Algorithms; D000818:Animals; D017360:Arabidopsis / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D005091:Exons; D016678:Genome; D006801:Humans; D007438:Introns; D012326:RNA Splicing