Hb Bologna-St. Orsola [beta146(HC3)His-->Tyr]: a new high oxygen affinity variant with halved Bohr effect and highly reduced reactivity towards 2,3-diphosphoglycerate.
Ivaldi
G
G
Laboratorio Genetica Umana, Ospedali Galliera, Genova, Italia. g.ivaldi@galliera.it
David
O
O
Paradossi
V
V
Baffico
M
M
Scimè Degani
V
V
Leone
D
D
Baldi
M
M
Parodi
M I
MI
Bernardi
P
P
Ricco
G
G
D019794:2,3-Diphosphoglycerate / Q000097:blood*; D000293:Adolescent; D000494:Allosteric Regulation; D019943:Amino Acid Substitution; D005260:Female; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood*; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D014443:Tyrosine / Q000737:chemistry*
D006455:Hemoglobins, Abnormal; D019794:2,3-Diphosphoglycerate; D014443:Tyrosine; D006639:Histidine; C031005:hemoglobin Bologna; D010100:Oxygen