Histology of familial thyroid tumours linked to a gene mapping to chromosome 19p13.2.
This paper describes the pathology of thyroid tumours showing an autosomal mode of inheritance linked to a gene that maps to chromosome 19p13.2. All the affected members from the family (seven males and two females; mean age 23 years) were clinically euthyroid and presented with nodular goitre; tumour recurrence after thyroidectomy was observed in four. In four of the five patients studied, the tumours were multifocal, bilateral well demarcated or encapsulated and composed of follicles, papillae, trabeculae/solid areas (often resembling hyalinizing trabecular adenoma of the thyroid) or an admixture, formed by cells with pale to intense cytoplasmic eosinophilia. A diagnosis of multiple adenomatous goitre was made in the thyroidectomy specimen from two patients, while the other two patients showed, in addition to multiple adenomas, a co-existent oxyphil papillary carcinoma. The fifth patient had an oxyphil cell carcinoma. All tumours were of follicular cell origin as shown by immunocytochemistry. Less than a third of the benign tumours and all three carcinomas showed a variable number of neoplastic cells diffusely immunostained for mitochondria. Histological findings of a 'multiple adenomatous goitre', non-endemic 'multinodular goitre' or multiple neoplasms of follicular cell origin with the morphology of those described here, particularly in young patients, should alert the pathologist and physician to the possibility of an inherited trait, with its implications for family screening. The tumours are usually benign and well demarcated but because of multicentricity and consequently increased risk of recurrence and/or progression to carcinoma, total thyroidectomy should be advocated.
Harach
H R
HR
Department of Histopathology and Morbid Anatomy, Royal London Hospital, London, U.K.
Lesueur
F
F
Amati
P
P
Brown
A
A
Canzian
F
F
Kraimps
J L
JL
Levillain
P
P
Menet
E
E
Romeo
G
G
Bonneau
D
D
D000236:Adenoma / Q000235:genetics / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics / Q000473:pathology*; D002648:Child; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005500:Follow-Up Studies; D008040:Genetic Linkage; D006044:Goiter, Nodular / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000235:genetics / Q000473:pathology*