title: An asymptomatic hypertrophic pacchionian granulation simulating osteolytic lesion of the calvaria.
abstract: Osteolytic lesions can be seen in various diseases. We present a rare case of symptomatic hypertrophic pacchionian granulation mimicking bone tumor in the calvaria. A 50-year-old woman suffered from a previous VII cranial nerve peripheral paresis accompanied by headache. A plain radiograph revealed a punched-out paramedial occipital lesion. Precontrast-enhanced computed tomographic scans demonstrated a hypodense mass, with a defect of both tables of the left occipital bone. Magnetic resonance imaging (MRI) demonstrated a hypointense mass on the T1-weighted image and isointense to cerebrospinal fluid on the T2-weighted image, with capsule-like contrast enhancement by gadolinium. A biopsy was performed. Histologically, hypertrophic pacchionian granulation was diagnosed. The patient has had no growth for 2 years. This case suggests the need to include hypertrophic pacchionian granulation in the differential diagnosis of punched-out lesions.
authors.affiliation: Department of Neurological Sciences, Chair of Neurosurgery, La Sapienza, University of Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Celli
authors.forename: L
authors.initials: L
authors.lastname: Cervoni
authors.forename: R
authors.initials: R
authors.lastname: Quasho
mesh_terms: D001099:Arachnoid / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006097:Granulation Tissue / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009777:Occipital Bone / Q000473:pathology*; D012888:Skull Neoplasms / Q000175:diagnosis* / Q000473:pathology