title: Role of cytokines in the metabolic response to stress.
abstract: Clinical trials with cytokine inhibitors have failed to show efficacy and confirm preclinical findings in sepsis and systemic inflammatory response syndromes. However, a better understanding of the pathogenesis of sepsis syndrome, and of proinflammatory cytokine signal transduction pathways, including the role of nuclear factor kappa B and inflammation-induced apoptosis, have provided new therapeutic opportunities for cytokine and anticytokine therapies.
authors.affiliation: Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Edwards
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D002986:Clinical Trials as Topic; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000503:physiopathology* / Q000628:therapy*; D016328:NF-kappa B / Q000378:metabolism; D018805:Sepsis / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D015398:Signal Transduction; D013312:Stress, Physiological / Q000503:physiopathology*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha