Vitamin D supplementation in postmenopausal black women.
Black women have lower levels of serum 25-hydroxyvitamin D (25OHD) with higher serum PTH levels than white women. Correction of these alterations in the vitamin D-endocrine system could lead to less bone loss in postmenopausal women and, consequently, preservation of bone mass. Ten healthy postmenopausal black women were given 20 microg vitamin D3 daily for 3 months. At the end of the study, mean serum 25OHD levels had increased from 24 to 63 nmol/L. Serum intact PTH and nephrogenous cAMP declined significantly, and there was a 21% drop in the fasting urinary N-telopeptide of type I collagen. Vitamin D3 supplementation raises serum 25OHD levels in postmenopausal black women, decreases secondary hyperparathyroidism, and reduces bone turnover. These findings should spur further investigation of the use of vitamin D supplementation in the prevention of osteoporosis in this population.
Kyriakidou-Himonas
M
M
Department of Medicine, Winthrop-University Hospital, Mineola, New York 11530, USA.
Aloia
J F
JF
Yeh
J K
JK
D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002136:Calcium, Dietary / Q000008:administration & dosage; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000627:therapeutic use; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D000242:Cyclic AMP / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000652:urine; D017698:Postmenopause
D002136:Calcium, Dietary; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D002762:Cholecalciferol; D003094:Collagen; D000242:Cyclic AMP; D002117:Calcitriol; D002112:Calcifediol