Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons.
Lai
J
J
Department of Pharmacology, University of Arizona, Tucson 85724, USA.
Hunter
J C
JC
Ossipov
M H
MH
Porreca
F
F
D000818:Animals; D002908:Chronic Disease; D004351:Drug Resistance; D015640:Ion Channel Gating; D008026:Ligation; D008161:Lumbosacral Region; D062556:NAV1.7 Voltage-Gated Sodium Channel; D062559:NAV1.8 Voltage-Gated Sodium Channel; D009475:Neurons, Afferent / Q000187:drug effects*; D009479:Neuropeptides / Q000187:drug effects / Q000235:genetics; D020319:Oligodeoxyribonucleotides, Antisense / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D010148:Intractable Pain / Q000188:drug therapy; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000187:drug effects; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects* / Q000235:genetics; D013127:Spinal Nerves / Q000601:surgery; D013779:Tetrodotoxin / Q000494:pharmacology
D062556:NAV1.7 Voltage-Gated Sodium Channel; D062559:NAV1.8 Voltage-Gated Sodium Channel; D009479:Neuropeptides; D020319:Oligodeoxyribonucleotides, Antisense; C568319:Scn10a protein, rat; C503480:Scn9a protein, rat; D015222:Sodium Channels; D013779:Tetrodotoxin