title: Serum IFN-gamma and IL-10 levels before and after specific immunotherapy in patients with allergic rhinitis.
abstract: Although a detailed explanation of the mechanism of immunotherapy is not known, several immunologic explanation have been proposed. It's said that T cell-cytokine profile changed with allergen immunotherapy. In our study we evaluated IFN-* and IL-10 levels before and after immunotherapy in patients with allergic rhinitis. Twenty patients (mean age; 27.3 +/- 4.84), 8 male, 12 female with allergic rhinitis, mean duration of disease was 5.55 +/- 1.23 years and 13 healthy controls, 5 male, 8 female (mean age: 28.38 +/- 5.61) were enrolled in the study. Immunotherapy was performed for grass pollen allergen extract to patients with allergic rhinitis for 31.5 +/- 4.98 months. Serum IL-10 and IFN-* levels were evaluated with ELISA. Serum IL-10 levels were significantly high before and after immunotherapy compared to controls. There was no difference in IFN-* levels before and after SIT compared to controls. According to this study, in patients with allergic rhinitis after immunotherapy serum IL-10 levels are decreased but IFN-* no change.
authors.affiliation: SSKAnkara Ihtisas Hospital Clinic Immunology and Rheumatology Department, Ankara, Türkiye.
authors.forename: G
authors.initials: G
authors.lastname: Keskin
authors.forename: A
authors.initials: A
authors.lastname: Inal
authors.forename: R
authors.initials: R
authors.lastname: Ali Sari
authors.forename: A
authors.initials: A
authors.lastname: Sengül
authors.forename: M
authors.initials: M
authors.lastname: Sahin
authors.forename: M
authors.initials: M
authors.lastname: Turgay
authors.forename: G
authors.initials: G
authors.lastname: Kinikli
mesh_terms: D000328:Adult; D000485:Allergens; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D006109:Poaceae; D011058:Pollen; D012221:Rhinitis, Allergic, Perennial / Q000097:blood* / Q000628:therapy
chemical_list: D000485:Allergens; D016753:Interleukin-10; D007371:Interferon-gamma