title: Pharmaceutical applications of the Prout-Tompkins rate equation.
abstract: More than 50 years ago, a paper by E.G. Prout and F.C. Tompkins was published in the Transactions of the Faraday Society. The paper dealt with the kinetics of the thermal decomposition of crystals of potassium permanganate, and suggested a rate equation, which has become known as the Prout-Tompkins equation, for use in the kinetic analysis of solid state reactions. The paper has been extensively cited in the literature. Applications of the Prout-Tompkins equation in pharmaceutical stability studies are reviewed in this short review.
authors.affiliation: Chemistry Department and School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa. m.brown@ru.ac.za
authors.forename: M E
authors.initials: ME
authors.lastname: Brown
authors.forename: B D
authors.initials: BD
authors.lastname: Glass
mesh_terms: D000465:Algorithms; D003460:Crystallization; D007700:Kinetics; D011196:Potassium Permanganate / Q000737:chemistry*
chemical_list: D011196:Potassium Permanganate