A pilot study of a new chicken model of alcohol-induced cardiomyopathy.
BACKGROUND
Excessive alcohol consumption is recognized as a common cause of left ventricular (LV) dysfunction. It is currently thought that 36% of all cases of dilated cardiomyopathy are due to excessive alcohol intake. Suitable animal models are needed to study the pathogenic mechanisms of ethanol-induced LV dysfunction. We have therefore created a new model of ethanol-induced LV dysfunction in the chicken.


METHODS
For 12 weeks, adult chickens were given, twice a day, by gavage, 73% of their total calculated daily water intake containing a 20% ethanol concentration. Twenty percent ethanol also was placed in the water and provided ad libitum. Control chickens received the same volume of water by gavage twice a day without ethanol. Water without ethanol was given ad libitum to control birds.


RESULTS
Our study shows that after a relatively short duration of ethanol ingestion, chickens developed LV dilatation and LV dysfunction. The serum concentrations of ethanol attained in this new model were similar to those reported in humans. Furthermore, unlike other currently available animal models of ethanol-induced cardiac disease, this model demonstrates myocyte hypertrophy, interstitial fibrosis, and myocytolysis, similar to observations in human ethanol-induced cardiac dysfunction.


CONCLUSIONS
We conclude that this new avian model should provide a useful tool for investigating the mechanism(s) and pathophysiology of ethanol-induced dilated cardiomyopathy and heart failure.
Morris
N
N
Angell Memorial Animal Hospital, Boston, Massachusetts, USA.
Kim
C S
CS
Doye
A A
AA
Hajjar
R J
RJ
Laste
N
N
Gwathmey
J K
JK
D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000000981:diagnostic imaging / Q000209:etiology*; D002492:Central Nervous System Depressants / Q000009:adverse effects* / Q000097:blood; D002645:Chickens; D004195:Disease Models, Animal; D004452:Echocardiography; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D009206:Myocardium / Q000473:pathology; D010865:Pilot Projects; D011859:Radiography; D011897:Random Allocation
D002492:Central Nervous System Depressants; D000431:Ethanol