Evaluation of oxygen consumption and resting energy expenditure in critically ill patients with systemic inflammatory response syndrome.
OBJECTIVE
To determine whether oxygen consumption VO2), CO2 production, and resting energy expenditure (REE) in critically ill patients differ in varying grades of systemic inflammatory response syndrome (SIRS).


METHODS
Prospective, clinical study.


METHODS
Intensive care unit at a university hospital.


METHODS
Twenty-six critically ill patients requiring mechanical ventilation.


METHODS
None.


RESULTS
A total of 100 metabolic measurements were performed. The grade of SIRS and the Acute Physiology and Chronic Health Evaluation II score were evaluated at the time of the metabolic cart study. VO2 and REE differed among the groups inadequate for SIRS (non-SIRS), with SIRS without infection (nonseptic SIRS), and with SIRS with infection (septic SIRS) (125 +/- 37 mL/min/m2 and 855 +/- 204 kcal/day/m2, 135 +/- 33 mL/min/m2 and 948 +/- 214 kcal/day/m2, and 166 +/- 55 mL/min/m2 and 1149 +/- 339 kcal/day/m2, respectively; p < .005). Patients with septic SIRS had higher VO2 and REE than patients with non-SIRS and nonseptic SIRS.


CONCLUSIONS
VO2 and REE differ among groups of patients with non-SIRS, nonseptic SIRS, and septic SIRS. Patients with septic SIRS have higher VO2 and REE than patients with non-SIRS or nonseptic SIRS. The present study shows that classifying patients into three grades (non-SIRS, nonseptic SIRS, and septic SIRS) is a valid predictor of metabolic stress in critically ill patients.
Moriyama
S
S
Division of Intensive and Critical Care Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan.
Okamoto
K
K
Tabira
Y
Y
Kikuta
K
K
Kukita
I
I
Hamaguchi
M
M
Kitamura
N
N
D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001784:Blood Gas Analysis; D002153:Calorimetry, Indirect; D002245:Carbon Dioxide / Q000378:metabolism; D016638:Critical Illness; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010288:Parenteral Nutrition; D011446:Prospective Studies; D012121:Respiration, Artificial; D012146:Rest; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism* / Q000628:therapy
D002245:Carbon Dioxide