title: Impact of sleep debt on metabolic and endocrine function.
abstract: BACKGROUND
  Chronic sleep debt is becoming increasingly common and affects millions of people in more-developed countries. Sleep debt is currently believed to have no adverse effect on health. We investigated the effect of sleep debt on metabolic and endocrine functions.
  
  
  METHODS
  We assessed carbohydrate metabolism, thyrotropic function, activity of the hypothalamo-pituitary-adrenal axis, and sympathovagal balance in 11 young men after time in bed had been restricted to 4 h per night for 6 nights. We compared the sleep-debt condition with measurements taken at the end of a sleep-recovery period when participants were allowed 12 h in bed per night for 6 nights.
  
  
  RESULTS
  Glucose tolerance was lower in the sleep-debt condition than in the fully rested condition (p<0.02), as were thyrotropin concentrations (p<0.01). Evening cortisol concentrations were raised (p=0.0001) and activity of the sympathetic nervous system was increased in the sleep-debt condition (p<0.02).
  
  
  CONCLUSIONS
  Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function. The effects are similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders.
authors.affiliation: Department of Medicine, University of Chicago, IL 60637, USA.
authors.forename: K
authors.initials: K
authors.lastname: Spiegel
authors.forename: R
authors.initials: R
authors.lastname: Leproult
authors.forename: E
authors.initials: E
authors.lastname: Van Cauter
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose; D002096:C-Peptide / Q000097:blood; D050260:Carbohydrate Metabolism; D004703:Endocrine System / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008297:Male; D010913:Pituitary-Adrenal System / Q000378:metabolism; D012892:Sleep Deprivation / Q000378:metabolism* / Q000503:physiopathology; D012894:Sleep Stages; D013564:Sympathetic Nervous System / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014630:Vagus Nerve / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone