title: Airway obstruction in bronchial sarcoidosis: outcome with treatment.
abstract: OBJECTIVE
  Airway obstruction (AO) in sarcoidosis is reported to be associated with respiratory symptoms, increased morbidity, and an increased mortality risk. Because AO in sarcoidosis may result from several causes, the therapeutic benefit of corticosteroids is difficult to determine. The aim of this study was to evaluate the therapeutic response of AO attributable to sarcoid granulomas in the bronchial wall.
  
  
  METHODS
  We selected 11 patients who had sarcoidosis with AO (defined as FEV(1)/vital capacity [VC] < 70%) associated with sarcoid granulomas on an endobronchial biopsy. Exclusion criteria were history of asthma, smoker or ex-smoker, stage 4 disease, evidence of extrinsic compression by enlarged lymph nodes, and localized endobronchial stenosis seen during fiberoptic bronchoscopy.
  
  
  METHODS
  We compared the results of pulmonary function tests and clinical, radiologic, and biological findings at baseline with those obtained at the time of the last pulmonary function tests available, between the sixth and 12th months of treatment. Eight patients took oral corticosteroids (20 to 60 mg/d initially), one received IV methylprednisolone pulses, another took oral hydroxychloroquine, and the last one received IM methotrexate.
  
  
  RESULTS
  With treatment, FEV(1) and FEV(1)/VC significantly improved in eight patients (72%), normalized in four patients, and was unchanged in the remaining three patients. The mean FEV(1) increased from 60.8 +/- 10.8% to 76 +/- 13.7% of the predicted value (p < 0.02). VC did not change significantly. FEV(1)/VC increased from 76.1 +/- 6.4% to 87.6 +/- 10.7% of the predicted value (p < 0.01). Dyspnea on exertion and other clinical findings were attenuated in 10 patients; the chest radiograph improved in 9 patients, and normalized in 5 patients. The mean serum angiotensin-converting enzyme level decreased from 112 +/- 48 to 58 +/- 40 IU/mL (p < 0.05), and normalized in four patients.
  
  
  CONCLUSIONS
  The present study indicates that AO caused by sarcoid granulomas in the bronchial wall can be either partially or completely reversed by treatment with a concomitant attenuation of pulmonary symptoms.
authors.affiliation: Service de Pneumologie, Hôpital Avicenne (Assistance Publique-Hôpitaux de Paris), UFR Bobigny, Bobigny, France.
authors.forename: F
authors.initials: F
authors.lastname: Lavergne
authors.forename: C
authors.initials: C
authors.lastname: Clerici
authors.forename: D
authors.initials: D
authors.lastname: Sadoun
authors.forename: M
authors.initials: M
authors.lastname: Brauner
authors.forename: J P
authors.initials: JP
authors.lastname: Battesti
authors.forename: D
authors.initials: D
authors.lastname: Valeyre
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000402:Airway Obstruction / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D001982:Bronchial Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001999:Bronchoscopy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D006886:Hydroxychloroquine; D008775:Methylprednisolone; D008727:Methotrexate