Induction of erythroid differentiation of human K562 cells by 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives.
In this paper we report the synthesis of twelve 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives and the results obtained on their effects in inducing erythroid differentiation of human leukemic K562 cells. The data obtained demonstrate that two of the newly synthetized compounds are able to induce erythroid differentiation of K562 cells. In addition, these same compounds potentiate K562 erythroid differentiation induced by cytosine arabinoside, retinoic acid and mithramycin. Inducers of erythroid differentiation stimulating fetal gamma-globin synthesis could be considered for possible use in the experimental therapy of hematological diseases associated with a failure in the expression of adult beta-globin genes.
Catelani
G
G
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Italy.
Osti
F
F
Bianchi
N
N
Bergonzi
M C
MC
D'Andrea
F
F
Gambari
R
R
D002454:Cell Differentiation / Q000187:drug effects*; D003561:Cytarabine / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000031:analogs & derivatives*; D006410:Hematopoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000096:biosynthesis; D006601:Hexoses / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D008926:Plicamycin / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology
D006454:Hemoglobins; D006601:Hexoses; D003561:Cytarabine; D014212:Tretinoin; D005947:Glucose; D008926:Plicamycin