Peptidoglycan biosynthesis. Unexploited antibacterial targets within a familiar pathway.
Wong
K K
KK
Department of Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Pompliano
D L
DL
D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D002237:Carbohydrate Dehydrogenases / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008956:Models, Chemical; D010453:Peptide Synthases / Q000378:metabolism; D010457:Peptidoglycan / Q000096:biosynthesis* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan; D002237:Carbohydrate Dehydrogenases; C023215:UDP-N-acetylmuramate dehydrogenase; D019883:Alkyl and Aryl Transferases; C022566:UDP-N-acetylglucosamine 1-carboxyvinyltransferase; D010453:Peptide Synthases