How beta-lactamases have driven pharmaceutical drug discovery. From mechanistic knowledge to clinical circumvention.
Bush
K
K
R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA.
Mobashery
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D015195:Drug Design; D006801:Humans; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases