title: Renal cell carcinoma with massive osseous metaplasia and bone marrow elements.
abstract: Focal calcifications are frequently seen in renal masses and may be present in renal cell carcinomas. Metaplastic bone formation, on the other hand, is a rare event. We report a unique case of a large calcified renal cell carcinoma with massive osseous metaplasia and bone marrow elements. The clinical and pathologic differential diagnosis for this tumor is discussed along with a review of the literature on this unusual phenomenon.
authors.affiliation: Departments of Pathology, Surgery, and Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Cribbs
authors.forename: M
authors.initials: M
authors.lastname: Ishaq
authors.forename: M
authors.initials: M
authors.lastname: Arnold
authors.forename: J
authors.initials: J
authors.lastname: O'Brien
authors.forename: J
authors.initials: J
authors.lastname: Lamb
authors.forename: W L
authors.initials: WL
authors.lastname: Frankel
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D008679:Metaplasia; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor