title: Role of myocardial ischemia and left ventricular wall motion abnormalities as contributory factors in the genesis of exercise-induced ST-segment elevation in Q-wave myocardial infarction.
abstract: In patients with a previous myocardial infarction, controversy exists regarding the significance of postexercise ST-segment elevation in the infarct-related leads. Although usually admitted to be a sign of left ventricular dysfunction or myocardial aneurysm, other studies however have related this finding to transient myocardial ischemia and to the presence of jeopardized but viable myocardium in the infarct area. The aim of the present study was to assess the significance of postexercise ST-segment elevation in Q-wave leads as a marker of transmural ischemia or left ventricular dysfunction in 36 consecutive patients, 16 with exercise-induced ST-segment elevation in infarct-related leads. Patients were evaluated by treadmill exercise testing, coronary angiography and ventriculography, thallium-201 tomographic scintigraphy and radionuclide ventriculography within 3 months of the first myocardial infarction. Sixteen patients (group I) had exercise-induced ST segment elevation and 20 (group II) postexercise inversion, no change or pseudonormalization of the T wave in infarct-related leads. The study showed no difference in infarct-related artery, vessel disease or luminal diameter stenosis in groups I and II. The overall agreement between ST shifts and myocardial perfusion in the infarct area was 30.56% with a kappa coefficient of -0.33 (p = NS). The overall agreement between ST shifts and wall motion abnormalities was 69.44% with a kappa coefficient of 0.39 (p < 0.01), stress-induced ST-segment elevation being associated with severe wall contractile disorders in 85% of the patients. In conclusion stress-induced ST-segment elevation in Q wave leads, although not a marker of wall motion abnormalities, is associated with akinesia or dyskinesia of the left ventricular wall.
authors.affiliation: St. Mary University Hospital, Department of Cardiology, Lisbon, Portugal.
authors.forename: E
authors.initials: E
authors.lastname: Macieira-Coelho
authors.forename: M
authors.initials: M
authors.lastname: Garcia-Alves
authors.forename: I
authors.initials: I
authors.lastname: Dionisio
authors.forename: G
authors.initials: G
authors.lastname: Cantinho
authors.forename: B B
authors.initials: BB
authors.lastname: Da Costa
authors.forename: A
authors.initials: A
authors.lastname: Gouveia
mesh_terms: D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000150:complications; D003331:Coronary Vessels / Q000473:pathology; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000209:etiology*; D017202:Myocardial Ischemia / Q000150:complications*; D005082:Physical Exertion / Q000502:physiology*; D011446:Prospective Studies; D015635:Radionuclide Ventriculography; D019275:Radiopharmaceuticals; D013667:Technetium; D013794:Thallium Radioisotopes; D014022:Tissue Survival; D014055:Tomography, Emission-Computed; D018487:Ventricular Dysfunction, Left / Q000150:complications*
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes; D013667:Technetium