Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology.
It is generally accepted that lipid peroxides play an important role in the pathogenesis of free radical-induced cellular injury and that antioxidants such as glutathione, ascorbic acid and alpha-tocopherol are vital in cellular defense against endogenous and exogenous oxidants. The purpose of this study was to investigate the effectiveness of a natural compound, derived from lemon oil extract, in controlling free radical-induced lipid peroxidation and tissue damage in the skin. We provide evidence that a compound isolated from lemon oil, which we have called Lem1, is endowed with a strong antioxidant activity and that it is capable of inhibiting free radical-mediated reactions, evaluated by both in vitro and in vivo biochemical systems. The present study aims to give a preclinical perspective on the biochemical properties of Lem1, a natural compound, as well as to provide a better understanding of the endogenous antioxidant potential of skin and the real validity of a natural antioxidant biotechnology in the antiaging management of the skin.
Calabrese
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Faculty of Medicine, Dept. of Chemistry, University of Catania, Italy. Calabrese@mbox.Unict.It
Randazzo
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Catalano
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Rizza
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D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001709:Biotechnology; D002851:Chromatography, High Pressure Liquid; D002957:Citrus; D003358:Cosmetics; D003879:Dermatologic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004341:Drug Evaluation; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
D000975:Antioxidants; D003358:Cosmetics; D003879:Dermatologic Agents; D005609:Free Radicals; D010938:Plant Oils