title: Lack of squamous cell lung carcinoma in vitro chemosensitivity to various drug regimens in the adenosine triphosphate cell viability chemosensitivity assay.
abstract: A pilot study on squamous cell lung carcinoma (LC) chemosensitivity in adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA) was performed. Besides the histological investigation, a modified ATP-CVA was used for the analysis of cancer cell chemosensitivity to four drug regimens, including topotecan, a promising agent for non-small-cell lung cancer (NSCLC) chemotherapy. Results of in vitro chemosensitivity testing showed chemoresistance or only weak response in the predominant amount of tumors.
authors.affiliation: European Laboratory Association Section Ibbenbüren, Germany. DRUVOGT@t-online.de
authors.forename: U
authors.initials: U
authors.lastname: Vogt
authors.forename: E
authors.initials: E
authors.lastname: Striehn
authors.forename: U
authors.initials: U
authors.lastname: Bosse
authors.forename: F
authors.initials: F
authors.lastname: Klinke
authors.forename: B
authors.initials: B
authors.lastname: Falkiewicz
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002470:Cell Survival; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged; D010865:Pilot Projects; D019772:Topotecan / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D019772:Topotecan