title: [Sudden death (II). Myocardial ischemia and ventricular arrhythmias in experimental models: triggering mechanisms].
abstract: Metabolic and electrolytic alterations generated in the acute ischemic myocardium, such as an increase in extracellular potassium or acidosis, are responsible for the occurrence of ventricular arrhythmias. In the first 5-10 minutes following coronary occlusion, reentry seems to have an important role, although not in the next 15 minutes. If the patient survives, a subacute arrhythmia period appears, 6 to 72 hours after the onset of ischemia, probably due to abnormal automaticity in the surviving Purkinje fibers. Finally, reentry in the epicardial border zone is the most likely mechanism for chronic arrhythmias. In this review we focus on the studies dealing with the mechanisms of ischemia-induced arrhythmias, with special reference to those conducted in experimental models.
authors.affiliation: Laboratorio A de Cardiología Experimental, Hospitals Vall d'Hebron, Barcelona. ars@hg.vhebron.es
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Sinovas
authors.forename: J
authors.initials: J
authors.lastname: Cinca
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004562:Electrocardiography; D006352:Heart Ventricles; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology