title: Use of a three-blood-sample plasma clearance technique to measure GFR in horses.
abstract: Measurement of renal function in horses poses a particular challenge because plasma creatinine is influenced by muscle mass which is highly developed and variable between individuals, while conventional clearance methods involve potentially daunting problems, particularly urine collection and bladder washout. This paper provides data which enable technetium-diethyleneaminopentacetic acid (Tc-DTPA) clearance to be used to calculate glomerular filtration rate (GFR)/extracellular fluid volume (ECFV) as an expression of GFR in horses, as previously validated in humans, dogs and calves. Apart from being arguably a more physiological expression of GFR than using derivatives of body weight, the use of GFR/ECFV eliminates a source of delay and error, namely measurement of the injected dose, and offers the convenience of requiring only three blood samples. It therefore has advantages for both research and clinical applications.
authors.affiliation: Formerly Royal Veterinary College, University of London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Gleadhill
authors.forename: D
authors.initials: D
authors.lastname: Marlin
authors.forename: P A
authors.initials: PA
authors.lastname: Harris
authors.forename: A R
authors.initials: AR
authors.lastname: Michell
mesh_terms: D000818:Animals; D001835:Body Weight; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006736:Horses / Q000502:physiology*; D019275:Radiopharmaceuticals; D012016:Reference Values; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate