[Clinical effectiveness of degradable starch microspheres (DSM) in patients with liver cancer].
Recently, degradable starch microspheres (DSM) have become available for use in patients with liver cancer in Japan. When DSM combined with a cytotoxic drug are infused through the hepatic artery, the steep drug concentration gradient to the tumor tissue results in a higher tissue drug concentration, which may elicit an increased antitumor response by blocking regional blood flow. Furthermore, the reduced systemic exposure of a coinjected drug can be translated into an increased regional extraction ratio due to blood flow reduction. DSM is infused via a catheter connecting to a subcutaneously implanted reservoir in outpatients. Pain is experienced by all patients. Other frequently observed adverse reactions are nausea and vomiting. However, these symptoms improve within a few hours. These observations indicate that intra-arterial chemotherapy combined with DSM may provide a more potent anticancer effect than a cytotoxic drug alone.
Kumada
T
T
Dept. of Gastroenterology, Ogaki Municipal Hospital.
Nakano
S
S
Sone
Y
Y
Kiriyama
S
S
Hisanaga
Y
Y
Rikitoku
T
T
Tamoto
A
A
Honda
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D008863:Microspheres; D016685:Mitomycin / Q000008:administration & dosage; D013213:Starch; D014057:Tomography, X-Ray Computed
D016685:Mitomycin; D013213:Starch