Pharmacokinetic analysis of neoplasms using contrast-enhanced dynamic magnetic resonance imaging.
Pharmacokinetic analysis using dynamic magnetic resonance imaging provides insight into various physiological aspects of tumors, including capillary wall permeability and the volume of the interstitial space. This physiology may be investigated in either a heuristic or model-based fashion using various methods presented in the literature. This review describes many of these approaches and provides some guidelines for those intending to use dynamic magnetic resonance imaging in the investigation of neoplasms.
Parker
G J
GJ
NMR Research Unit, Institute of Neurology, University College London, United Kingdom. g.parker@ion.ucl.ac.uk
Tofts
P S
PS
D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D012680:Sensitivity and Specificity; D013997:Time Factors
D003287:Contrast Media