title: Successful treatment of collagen-induced arthritis in mice with a hydroalcohol extract of seeds of Pterodon pubescens.
abstract: The antiarthritic effect of a hydroalcohol extract of Pterodon pubescens (HEPp) seeds was tested using collagen-induced arthritis (CIA) in DBA1/J mice treated with daily oral doses of HEPp in different schedules. The preventive treatment significantly reduced both the arthritic index (AI) and the CIA incidence. Using a therapeutic protocol, only the lower dose of HEPp induced a decrease in both parameters. These results provide a scientific foundation for the popular use of Pp seed infusions in rheumatoid arthritis (RA) treatment.
authors.affiliation: Departamento de Bioquímica, Instituto de Biologia, Centro Biomédico, Universidade do Estado do Rio de Janeiro, 20511-013, Programa de Medicina Experimental, INCA, Rio de Janeiro, RJ, Brazil.
authors.forename: K C
authors.initials: KC
authors.lastname: Sabino
authors.forename: F A
authors.initials: FA
authors.lastname: Castro
authors.forename: J C
authors.initials: JC
authors.lastname: Oliveira
authors.forename: S R
authors.initials: SR
authors.lastname: Dalmau
authors.forename: M G
authors.initials: MG
authors.lastname: Coelho
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003094:Collagen / Q000633:toxicity*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D003094:Collagen