title: Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand.
abstract: Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.
authors.affiliation: Department of Retrovirology, U.S. Army Component, Bangkok, Thailand. LTC-George_Watt@WRSMTP.CCMAIL.ARMY.MIL
authors.forename: G
authors.initials: G
authors.lastname: Watt
authors.forename: P
authors.initials: P
authors.lastname: Kantipong
authors.forename: K
authors.initials: K
authors.lastname: Jongsakul
authors.forename: P
authors.initials: P
authors.lastname: Watcharapichat
authors.forename: D
authors.initials: D
authors.lastname: Phulsuksombati
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology / Q000627:therapeutic use*; D004318:Doxycycline / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D012285:Orientia tsutsugamushi / Q000187:drug effects*; D011247:Pregnancy; D012612:Scrub Typhus / Q000188:drug therapy* / Q000382:microbiology; D013753:Tetracycline Resistance; D013785:Thailand
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D004318:Doxycycline