title: Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.
abstract: Guanidine-substituted imidazoles were prepared and evaluated as inhibitors of the three isoforms of nitric oxide synthase. These results identify a new 2-substituted imidazole as an isoform selective inhibitor and illustrate the possible importance of the L-arginine side chain in selective isoform recognition.
authors.affiliation: Department of Chemistry, Wake Forest University Winston-Salem, NC 27109, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Atkinson
authors.forename: S B
authors.initials: SB
authors.lastname: King
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D019791:Guanidine / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D004791:Enzyme Inhibitors; D007093:Imidazoles; D019001:Nitric Oxide Synthase; D019791:Guanidine