title: Successful treatment of Candida albicans endocarditis in a child with leukemia--a case report and review of the literature.
abstract: Candida species is now being increasingly recognised as an important cause of endocarditis especially in immunocompromised patients. A case of Candida albicans endocarditis in a child with acute lymphoblastic leukemia (ALL) is reported. The child did not have a central venous catheter at any time. Treatment consisted of intravenous amphotericin B and fluconazole for 3 weeks followed by oral fluconazole for 2 weeks. No surgical resection was necessary. We highlight here the importance of echocardiography in the management of prolonged febrile neutropenia and discuss the dilemma of continuing chemotherapy in such patients.
authors.affiliation: Department of Paediatrics, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
authors.forename: H
authors.initials: H
authors.lastname: Ariffin
authors.forename: W
authors.initials: W
authors.lastname: Ariffin
authors.forename: S
authors.initials: S
authors.lastname: Tharam
authors.forename: A
authors.initials: A
authors.lastname: Omar
authors.forename: J
authors.initials: J
authors.lastname: de Bruyne
authors.forename: H P
authors.initials: HP
authors.lastname: Lin
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004696:Endocarditis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole