Simple numerical chromosome aberrations characterize pituitary adenomas.
Although pituitary adenomas are among the most frequent intracranial neoplasms, only very few have been cytogenetically analyzed. We have short-term cultured and karyotyped 28 consecutive pituitary adenomas (16 clinically nonfunctioning adenomas and 12 clinically functioning adenomas), finding a normal karyotype in 22, whereas 6 had clonal chromosome aberrations (5 nonfunctioning pituitary adenomas and 1 prolactinoma). The abnormal karyotypes were relatively simple. Most anomalies were numerical, with a structural rearrangement, t(6;19), being found in only one tumor. The most common aberrations were trisomy 7 (3 adenomas), trisomy 9 (2 adenomas), trisomy 12 (2 adenomas), trisomy 20 (2 adenomas), and loss and gain in 2 separate clones of one X chromosome (2 adenomas).
Larsen
J B
JB
Department of Pathology, Odense University Hospital, Denmark.
Schrøder
H D
HD
Sørensen
A G
AG
Bjerre
P
P
Heim
S
S
D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D002877:Chromosomes, Human / Q000235:genetics; D002999:Clone Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic / Q000235:genetics; D014314:Trisomy / Q000235:genetics; D014960:X Chromosome / Q000235:genetics