Correlation between tumor angiogenesis and expression of thymidine phosphorylase, and patient outcome in uterine cervical carcinoma.
The relationship between tumor angiogenesis and the expression of thymidine phosphorylase (dThdPase) in uterine cervical carcinoma tissues, as well as patient outcome, were investigated. Primary tumor specimens surgically obtained from 54 patients (stages Ib to IIIb) receiving neither chemotherapy nor radiation therapy before surgery were examined. Intratumoral microvessel density (IMVD) and dThdPase expression were evaluated immunohistochemically using anti-CD34 and anti-dThdPase antibodies and were correlated with clinicopathologic parameters and prognosis. IMVD for the 54 tumors ranged from 24.8 to 118.6, with a median value of 57.7 (number/0.7386 mm2/field). For immunoreactivity of dThdPase, 16 tumors were graded as -, 20 as 1+, and 18 as 2+. IMVD was significantly associated with the expression of dThdPase (P<.01). Both IMVD and dThdPase expression were well correlated with depth of myometrial invasion, endometrial invasion, and pelvic lymphnode metastasis (P<.05). Overall survival rates for 18 patients with strong dThdPase-staining tumors, assessed as 2+, were lower than those for 36 with weak dThdPase staining tumors (P = .0108). However, there was no statistical correlation between IMVD and patient outcome. The expression of dThdPase plays a role in the promotion of angiogenesis and affects the patient's survival in uterine cervical carcinomas.
Ueda
M
M
Department of Obstetrics and Gynecology, Osaka Medical College, Japan.
Terai
Y
Y
Kumagai
K
K
Ueki
K
K
Okamoto
Y
Y
Ueki
M
M
D018952:Antigens, CD34 / Q000096:biosynthesis; D002277:Carcinoma / Q000098:blood supply* / Q000201:enzymology* / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D015996:Survival Rate; D013939:Thymidine Phosphorylase / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000098:blood supply* / Q000201:enzymology* / Q000378:metabolism / Q000401:mortality / Q000628:therapy
D018952:Antigens, CD34; D013939:Thymidine Phosphorylase