title: Percutaneous balloon valvuloplasty for congenital pulmonary valve stenosis in adults.
abstract: BACKGROUND
  Although pulmonary valvular stenosis is not uncommon in adults, there are few reports of percutaneous pulmonary valvuloplasty in adults, despite the possibility of avoiding heart surgery.
  
  
  OBJECTIVE
  This report describes the experience in adult patients undergoing this procedure and evaluates its effectiveness and tolerance.
  
  
  METHODS
  Over an 8-year period (1989-1997), pulmonary valvuloplasty was considered in 22 adult patients [8 men, 14 women; mean age 28.0 years +/- standard deviation (SD) 10.3; range 16-46 years] with congenital pulmonary valve stenosis. Sixteen patients were asymptomatic with pulmonary systolic murmurs, although 6 patients presented with dyspnea. Before the procedure, the mean transpulmonary valve gradient was 53.2 +/- 24.8 mmHg SD, with a mean right ventricular systolic pressure of 74.6 +/- 28.4 mmHg SD, and mean pulmonary artery pressure was 21.4 +/- 6.4/10.2 +/-3.9 mmHg.
  
  
  RESULTS
  The procedure was successful in 19 patients (6 men, 13 women) and was well tolerated and free of complications. Following the procedure, the mean transvalvular gradient was 15.5 +/- 11.5 mmHg, with a mean right ventricular systolic pressure of 40.5 +/- 13.6 mmHg and a mean pulmonary systolic pressure of 24.3 +/- 7.4 mmHg. This represented mean fall in transpulmonary valve gradient of 42.4 +/- 22.0 mmHg (paired t-test, p < 0.0001). After a mean follow-up of 20.1 months (13.4 SD), most patients remained well and asymptomatic, although two patients required repeat valvuloplasty.
  
  
  CONCLUSIONS
  Pulmonary valvuloplasty is a well tolerated and effective treatment for pulmonary valve stenosis in adults, with few complications and no need for surgery. This procedure should be considered as the primary treatment of adult patients with pulmonary valve stenosis.
authors.affiliation: Department of Cardiology, City Hospital, Birmingham, England.
authors.forename: G Y
authors.initials: GY
authors.lastname: Lip
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: de Giovanni
mesh_terms: D000293:Adolescent; D000328:Adult; D002404:Catheterization / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011666:Pulmonary Valve Stenosis / Q000151:congenital / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome