Action of methanolic extract of mung bean hulls as inhibitors of lipid peroxidation and non-lipid oxidative damage.
The antioxidant effects of methanolic extract of mung bean hulls (MEMBH) on lipids and non-lipids, including liposome, carbohydrate, protein and 2'-deoxyguanosine (2'-dG), were investigated. MEMBH exhibited a remarkable antioxidant effect in a liposome model system, indicating that the extract was an inhibitor of lipid peroxidation. The inhibitory effect of MEMBH on deoxyribose damage was amount-dependent and it afforded considerable protection against damage to deoxyribose. In addition, MEMBH at low amounts was more effective in protecting protein oxidation. Furthermore, the oxidation of 2'-dG to 8-hydroxy-2'-deoxyguanosine (8-OH-2'dG) was inhibited by MEMBH. These results show that the extract also was an inhibitor of non-lipid oxidation damage. The extract exhibited metal binding ability and scavenging activity for hydrogen peroxide and hydroxyl radical, which may explain the mechanism of their protecting lipids and non-lipids from oxidative damage.
Duh
P D
PD
Department of Food Health, Chia Nan College of Pharmacy and Science, Tainan Hsien, Taiwan, ROC.
Du
P C
PC
Yen
G C
GC
D000975:Antioxidants / Q000494:pharmacology*; D003849:Deoxyguanosine / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000037:antagonists & inhibitors*; D008081:Liposomes / Q000378:metabolism; D000432:Methanol; D016877:Oxidants / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D010084:Oxidation-Reduction / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D010946:Plants, Medicinal
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D007502:Iron Chelating Agents; D008055:Lipids; D008081:Liposomes; D016877:Oxidants; D010743:Phospholipids; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D003849:Deoxyguanosine; D000432:Methanol