title: Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro.
abstract: A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard alpha-tocopherol.
authors.affiliation: Laboratoire de Chimie Analytique et Electrochimie, UMR 8638 CNRS-Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Larget
authors.forename: B
authors.initials: B
authors.lastname: Lockhart
authors.forename: B
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: A
authors.initials: A
authors.lastname: Neudorffer
authors.forename: M B
authors.initials: MB
authors.lastname: Fleury
authors.forename: M
authors.initials: M
authors.lastname: Largeron
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D002460:Cell Line; D006624:Hippocampus / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000627:Aminophenols; D000975:Antioxidants; D018696:Neuroprotective Agents; D014810:Vitamin E