title: Repeated ultrasonically guided needle biopsy of small subpleural nodules.
abstract: OBJECTIVE
  To detect the significance of repeated ultrasonically guided needle biopsy (UGNB) for the diagnosis of nodular lesions </= 2 cm in diameter.
  
  
  METHODS
  Retrospective study to evaluate the diagnostic yield of UGNB.
  
  
  METHODS
  University hospital, outpatients, and inpatients of the respiratory department.
  
  
  METHODS
  One hundred seven cases with small nodular lesions </= 2 cm in diameter in contact with the pleura. Sixty-two of 107 cases were malignant, and the others were benign diseases.
  
  
  RESULTS
  Initial UGNB identified 56% (35/62) of the malignant lesions and 16% (7/45) of the benign lesions, ie, 39% (42/107) of the total. In 35 of 65 cases that were not diagnosed by the initial UGNB, it was repeated. Diagnostic yields of the second UGNB were 68% (13/19) of the malignant cases, 25% (4/16) of the benign cases, yielding a total of 49% (17/35) in those reexamined. Furthermore, 51 of 65 patients with negative findings on the initial UGNB underwent fiberoptic bronchoscopy. The resulting diagnostic yields were 22% (5/23) from the malignant lesions and 18% (5/28) from the benign lesions, 20% (10/51) in total. Thus, among the malignant cases, the repetition of UGNB increased the definitive diagnostic yield from 56% (the initial UGNB) to 77%. In these small tumors, no serious complications were caused by the procedure.
  
  
  CONCLUSIONS
  UGNB should be performed twice for a definitive diagnosis of small subpleural nodules before deciding on surgical biopsy or follow-up.
authors.affiliation: Department of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Obata
authors.forename: J
authors.initials: J
authors.lastname: Ueki
authors.forename: T
authors.initials: T
authors.lastname: Dambara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D001999:Bronchoscopy; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D005336:Fiber Optic Technology; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D007297:Inpatients; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D010045:Outpatients; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D014463:Ultrasonography