Enhancement of soluble CD23 levels in the seminal plasma of infertile men with idiopathic testicular lesion.
Since increased levels of soluble CD23 (sCD23) were demonstrated in patients with autoimmune diseases, seminal plasma sCD23 levels were examined in 110 men divided into seven groups according to etiological diagnosis of infertility and two groups on the basis of normal or abnormal spermiogram. sCD23 was absent in the seminal plasma of normal men: According to the ANOVA results, all measurements were significantly different between the groups of patients examined (p<.01). Specifically, patients with idiopathic testicular lesion have a significantly higher mean value of sCD23 than all other patients. A statistically significant difference was noted in the sCD23 levels between men with normal and those with abnormal spermiograms, although with wide overlapping of the individual values. Men with idiopathic testicular lesion may be immunologically more active than other groups with subfertility.
Matalliotakis
I
I
Department of Obstetrics and Gynecology, University of Crete, Greece.
Fragouli
Y
Y
Kyriakou
D
D
Goumenou
A
A
Matalliotakis
G
G
Koumantakis
E
E
D000328:Adult; D015415:Biomarkers; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D017455:Receptors, IgE / Q000378:metabolism*; D012661:Semen / Q000378:metabolism*; D013076:Sperm Count; D013081:Sperm Motility; D013733:Testicular Diseases / Q000378:metabolism*
D015415:Biomarkers; D017455:Receptors, IgE