title: In-vitro activity of voriconazole (UK-109,496), LY303366 and other antifungal agents against oral Candida spp. isolates from HIV-infected patients.
abstract: In this report we compare the activity of two new antifungal agents, voriconazole (UK-109,496) and LY303366 with the activities of other antifungals including fluconazole, itraconazole, 5-fluorocytosine (5FC) and amphotericin B against 219 oral Candida spp. isolates from HIV-infected patients. We used the broth microdilution method following the guidelines of the NCCLS. The in-vitro activity of voriconazole (UK-109,496) (MIC(90) 0.12 mg/L) and LY303366 (CMI(90) 0.25 mg/L) against clinical isolates of Candida spp. was excellent and comparable with that of amphotericin B (MIC(90) 0.5 mg/L), and better than those of fluconazole (MIC(90) > or = 64 mg/L), itraconazole (MIC(90) 4 mg/L) and 5FC (MIC(90) 1 mg/L).
authors.affiliation: Servicio de Microbiología Clínica, Hospital Universitario de Valme, E-41014 Sevilla, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Chávez
authors.forename: S
authors.initials: S
authors.lastname: Bernal
authors.forename: A
authors.initials: A
authors.lastname: Valverde
authors.forename: M J
authors.initials: MJ
authors.lastname: Gutierrez
authors.forename: G
authors.initials: G
authors.lastname: Quindós
authors.forename: E M
authors.initials: EM
authors.lastname: Mazuelos
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology; D000077612:Anidulafungin; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000382:microbiology*; D054714:Echinocandins; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000077612:Anidulafungin; D065819:Voriconazole