title: Distribution of glucose transporter isoform-3 and hexokinase I in the postnatal murine brain.
abstract: The facilitative glucose transporter-3 (GLUT 3) and hexokinase I were examined in postnatal mouse brains using immunohistochemical methods. GLUT 3 demonstrated a polarized distribution limited to neuronal processes of most anatomical regions except the suprachiasmatic nucleus and the cerebellum, where GLUT 3 expression was limited to neuronal cell somata. In contrast, hexokinase I was observed in the cytoplasm of neuronal and non-neuronal (subependymal and choroid plexus epithelial) cell bodies in all regions. In general, while the spatial distribution of GLUT 3 and hexokinase I did not change with age, a temporal increase in intensity was noted in all regions except for the decline in suprachiasmatic nuclear GLUT 3 immunoreactivity.
authors.affiliation: Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh, PA, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Fields
authors.forename: L
authors.initials: L
authors.lastname: Rinaman
authors.forename: S U
authors.initials: SU
authors.lastname: Devaskar
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D001923:Brain Chemistry / Q000502:physiology*; D002531:Cerebellum / Q000737:chemistry / Q000201:enzymology / Q000254:growth & development; D002831:Choroid Plexus / Q000737:chemistry / Q000201:enzymology / Q000254:growth & development; D018891:Dentate Gyrus / Q000737:chemistry / Q000201:enzymology / Q000254:growth & development; D051274:Glucose Transporter Type 3; D006593:Hexokinase / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009004:Monosaccharide Transport Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins; D013493:Suprachiasmatic Nucleus / Q000737:chemistry / Q000201:enzymology / Q000254:growth & development
chemical_list: D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495689:Slc2a3 protein, mouse; D006593:Hexokinase