title: Circadian intraocular pressure variation with beta-blockers.
abstract: OBJECTIVE
  To investigate circadian intraocular pressure variation in patients treated with topical beta-blockers as monotherapy.
  
  
  METHODS
  Circadian IOP curves were measured on 25 patients (47 eyes) treated with topical beta-blockers. IOP was recorded 4 times during the day and twice at night. All IOP measurements were taken using a non-contact tonometer.
  
  
  RESULTS
  IOP at night was significantly higher than IOP during the day. Thirty-four percent exhibited an increase in IOP of more than 5 mmHg at night, and 15% exhibited an increase of 10-18 mmHg at night. The median range of circadian IOP variation was 7 mmHg. Determined separately by day, the range of IOP variation was 4 mmHg.
  
  
  CONCLUSIONS
  Patients treated with beta-blockers as monotherapy may experience greater variations in IOP than can be detected by conventional daytime IOP measurements.
authors.affiliation: Department of Ophthalmology, Arhus University Hospital, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Krag
authors.forename: H B
authors.initials: HB
authors.lastname: Andersen
authors.forename: T
authors.initials: T
authors.lastname: Sørensen
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
chemical_list: D000319:Adrenergic beta-Antagonists