title: Genetics of male subfertility: consequences for the clinical work-up.
abstract: Major principles of genetic failures, chromosomal alterations and the most common syndromes associated with male subfertility should be taken into account before medical therapy and sophisticated techniques of assisted fertilization are applied to help a couple conceive. This review addresses the most common genetic reasons for male subfertility or infertility with special regard to the importance for the clinical work-up in daily routine and the potential risks for the conceptus.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University Lübeck, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Küpker
authors.forename: E
authors.initials: E
authors.lastname: Schwinger
authors.forename: O
authors.initials: O
authors.lastname: Hiort
authors.forename: M
authors.initials: M
authors.lastname: Ludwig
authors.forename: N
authors.initials: N
authors.lastname: Nikolettos
authors.forename: P N
authors.initials: PN
authors.lastname: Schlegel
authors.forename: K
authors.initials: K
authors.lastname: Diedrich
mesh_terms: D002869:Chromosome Aberrations; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D017353:Gene Deletion; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009154:Mutation; D009845:Oligospermia / Q000235:genetics; D011944:Receptors, Androgen / Q000235:genetics; D014998:Y Chromosome
chemical_list: C505032:CFTR protein, human; D011944:Receptors, Androgen; D019005:Cystic Fibrosis Transmembrane Conductance Regulator