Regulation of actin dynamics: The LIM kinase connection.
A signalling pathway has recently been delineated that connects Rho-family GTPases to the cytoskeleton via LIM kinase and the F-actin depolymerising protein cofilin. The existence of this pathway helps to explain some of the effects of LIM kinase and cofilin in the control of actin dynamics.
Lawler
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Centre for Molecular Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK.
D051339:Actin Depolymerizing Factors; D000199:Actins / Q000378:metabolism*; D003599:Cytoskeleton; D005057:Eukaryotic Cells; D020558:GTP Phosphohydrolases / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D054461:Lim Kinases; D008840:Microfilament Proteins / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D054462:p21-Activated Kinases; D054460:rho-Associated Kinases
D051339:Actin Depolymerizing Factors; D000199:Actins; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D011494:Protein Kinases; D054461:Lim Kinases; D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases; D054460:rho-Associated Kinases; D020558:GTP Phosphohydrolases