Seroepidemiology of human group C rotavirus in South Africa.
Sera from three separate healthy population cohorts were used to determine the incidence of group C rotavirus infections in 1,356 South Africans. Using an enzyme-linked immunosorbent assay based on a recombinant group C rotavirus VP6 protein, the total percent positivity was found to be 34.4% (range, 33 to 38%), with almost half of the population infected after the age of 20 years.
Steele
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AD
MRC/Medunsa Diarrhoeal Pathogens Research Unit, Medical University of Southern Africa, Pretoria, South Africa. adsteele@medunsa.ac.za
James
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VL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral; D002213:Capsid / Q000235:genetics / Q000276:immunology; D036022:Capsid Proteins; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015994:Incidence; D007223:Infant; D008875:Middle Aged; D011994:Recombinant Proteins / Q000276:immunology; D012401:Rotavirus / Q000145:classification / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology; D016036:Seroepidemiologic Studies; D013019:South Africa / Q000453:epidemiology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D011994:Recombinant Proteins; C061332:VP6 protein, Rotavirus