Retinoids and cell growth in the cardiovascular system.
Deficiency of vitamin A and its retinoid metabolites has been associated with a number of developmental abnormalities in the cardiovascular system. Many of these effects are mimicked by targeted deletion of retinoic acid receptors in the embryo. Retinoids also display anti-growth activity in fully differentiated cardiac and vascular cells. These activities together with favorable effects on the clotting mechanism suggest that retinoids may prove useful in the management of hypertrophic/hyperproliferative disorders of the heart and vascular wall.
Gardner
D G
DG
Department of Medicine, University of California at San Francisco 94143-0540, USA. gardner@itsa.ucsf.edu
Chen
S
S
D000818:Animals; D002319:Cardiovascular System / Q000166:cytology* / Q000187:drug effects* / Q000254:growth & development; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D012176:Retinoids / Q000494:pharmacology*
D012176:Retinoids