title: [Potential of selenium in gynecologic oncology].
abstract: BACKGROUND
  Studies on potential benefits of selenite in cancers of the female genital tract and breast cancer have concentrated on 2 fields: prevention on one side, complementary oncological therapy on the other side. Big studies have been realized in the past which have shown no clear effect of selenium supplementation in prevention of female cancers and breast cancer in the industrialized nations of Europe and Northern America. Few investigations exist on the therapeutic effects of selenium therapy in the clinical field of gyneco-oncology.
  
  
  RESULTS
  Many patients with malignant disease of the female breast and genital tract are strongly demanding additional therapeutical concepts in natural medicine in addition to adjuvant or palliative chemo- or hormonal therapy and supportive medication. In pilot studies with low-dose natrium selenite (up to 300 micrograms/day) they report a better quality of life. Side effects were not reported. Analysis of the immune system reveal a stimulation of B19 lymphocytes and natural killer cells.
  
  
  CONCLUSIONS
  In Germany, a country with selenium deficiency, clinical studies are now carried out on the effects of selenium as a drug to reduce side effects of chemo- and radiotherapy, enhance quality of life by reducing toxic side effects and help to restore immune function.
authors.affiliation: Universitäts-Frauenklinik Köln. bonn.anna.funke.dr@t-online.de
authors.forename: A M
authors.initials: AM
authors.lastname: Funke
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D006801:Humans; D010865:Pilot Projects; D011788:Quality of Life; D018038:Sodium Selenite / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D018038:Sodium Selenite