Predicting the severity of graft-versus-host disease from interleukin-10 levels after bone marrow transplantation.
Acute graft-versus-host disease (GVHD) is the most important complication of allogeneic bone marrow transplantation. We investigated the possibility of predicting severe acute GVHD using plasma interleukin-10 levels in 31 patients who underwent allogeneic bone marrow transplantation. In patients with acute GVHD, the interleukin-10 (IL-10) level increased significantly from the aplastic phase through the leukocyte recovery phase after transplantation (P < 0.05, paired t-test). The ratio of the IL-10 level in the aplastic phase to that in the leukocyte recovery phase was significantly correlated with the severity of acute GVHD (P < 0. 05, t-test), and the incidence of grade III or IV disease was significantly increased (P < 0.0001). Since IL-10 antagonizes various other cytokines that induce acute GVHD, determination of the IL-10 level is equivalent to assessing the total production of cytokines promoting GVHD. The ratio of the IL-10 level in the aplastic phase to that in the recovery phase seems to be useful for predicting the subsequent risk of acute GVHD.
Takatsuka
H
H
Second Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan.
Takemoto
Y
Y
Okamoto
T
T
Fujimori
Y
Y
Tamura
S
S
Wada
H
H
Okada
M
M
Yamada
S
S
Kanamaru
A
A
Kakishita
E
E
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000276:immunology*; D006410:Hematopoiesis; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D008297:Male; D012307:Risk Factors; D014184:Transplantation, Homologous
D016753:Interleukin-10