National Institute of Environmental Health Sciences (NIEHS); the Murine Local Lymph Node Assay: a Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, report now available. Public Health Service.
The report entitled "The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds," NIH Publication 99-4494, is now available and may be obtained as described in this notice.  The report describes the results of an independent peer review evaluation of the validation status of the Local Lymph Node Assay (LLNA) that was conducted on September 17, 1998 (Federal Register 63 FR 37405-6, July 10, 1998).  The (LLNA) was proposed as an alternative toxicological test method for assessing the allergic contact dermatitis (contact hypersensitivity) potential of chemicals and products.  The review was coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM).  The review was sponsored by the National Institute of Environmental Health Sciences and the NTP.
D000826:Animal Testing Alternatives / Q000331:legislation & jurisprudence; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D017408:Guidelines as Topic; D006168:Guinea Pigs; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D017712:Peer Review, Research; D018675:Toxicity Tests / Q000379:methods*; D014481:United States