title: Prevention of adverse events in hospitalized patients using an antimicrobial review program.
abstract: OBJECTIVE
  To evaluate whether an antimicrobial review system is associated with a reduction in antimicrobial-associated adverse events.
  
  
  METHODS
  All antimicrobial medication orders for patients hospitalized over a two-year period were evaluated. High-level interventions intended to prevent adverse antimicrobial events were collated. Based on literature estimates of adverse antimicrobial events, potential reduction of high-level adverse antimicrobial events was estimated.
  
  
  METHODS
  Department of Clinical Pharmacy and Division of Infectious Diseases at a tertiary care teaching hospital.
  
  
  RESULTS
  A total of 452 interventions were classified as "high-level." The incidence of preventable adverse antimicrobial events requiring intervention was 16 per 1000 antimicrobial orders. The incidence of high-level errors necessitating intervention was 4.4 per 1000 antimicrobial orders. An estimated 125 to 198 high-level adverse events were avoided.
  
  
  CONCLUSIONS
  An antimicrobial review program has the potential to reduce significant adverse events in hospitalized patients.
authors.affiliation: Department of Clinical Pharmacy, School of Pharmacy, University of California at San Francisco 94143-0622, USA. bjg@itsa.ucsf.edu
authors.forename: B J
authors.initials: BJ
authors.lastname: Guglielmo
authors.forename: A D
authors.initials: AD
authors.lastname: Luber
authors.forename: R L
authors.initials: RL
authors.lastname: Corelli
authors.forename: J F
authors.initials: JF
authors.lastname: Flaherty
authors.forename: R A
authors.initials: RA
authors.lastname: Jacobs
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016903:Drug Monitoring; D017723:Drug Utilization Review; D005845:Georgia; D006801:Humans; D010607:Pharmacy Service, Hospital
chemical_list: D000900:Anti-Bacterial Agents