[Technique and pathophysiology of isolated hypoxic perfusion of the abdomen].
Isolated hypoxic perfusion (IHP) is a commonly used technique in the treatment of abdominal malignancies. During a phase II-study the pathophysiology of this technique was explored in patients with advanced pancreatic cancer. Twenty perfusions of the abdomen were performed in 17 patients. Under general anesthesia, femoral vessels were dissected and two balloon catheters were inserted into aorta and vena cava cranial the celiac trunk and the hepatic veins. After instillation of 40 mg of Mitomycin C (MMC) into the running perfusion system, the perfusion was maintained for further 20 minutes. Blood samples were taken in 5-minute intervals to determine pH value, blood gases as well as concentrations of electrolytes, lactate and MMC in the arterial blood. Simultaneously, blood samples were taken from the perfusion blood via a side-port of the extracorporeal perfusion system. Additionally, perfusion pressures, arterial and central venous pressure, heart rate, and the pressure in the aorta distal the balloon catheter were registered continuously. All 20 perfusions had been undertaken without perioperative mortality. After inflating the balloon catheters, blood pressure and heart rate increased rapidly. Within 5 minutes of perfusion an increase in pCO2 and the concentrations of K+ and lactate in the perfusate were registered, while pH and pO2 decreased. Fifteen minutes after instillation of MMC, concentrations of MMC in arterial and perfusion blood were equal. Twenty-four hours after the perfusion all parameters had returned to normal values. IHP was well feasible in 20 consecutive perfusions without major technical problems. A distinct but tolerable combined acidosis resulted from IHP. Despite the exact positioning and control of the balloon catheters a complete isolation was not possible.
Petrowsky
H
H
Klinik für Allgemein- und Gefässchirurgie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt/M.
Heinrich
S
S
Janshon
G
G
Staib-Sebler
E
E
Poloczek
Y
Y
Gog
C
C
Oremek
G
G
Lorenz
M
M
D000136:Acid-Base Equilibrium / Q000502:physiology; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002245:Carbon Dioxide / Q000097:blood; D002404:Catheterization / Q000295:instrumentation; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D019344:Lactic Acid / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D010100:Oxygen / Q000097:blood; D010179:Pancreas / Q000098:blood supply*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D000903:Antibiotics, Antineoplastic; D002245:Carbon Dioxide; D019344:Lactic Acid; D016685:Mitomycin; D010100:Oxygen