Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis.
The CSF level of the isoprostane 8-epi-prostaglandin (PG)-F2alpha (a reliable marker of oxidative stress in vivo) was three times higher in subjects with definite MS than in a benchmark group of subjects with other neurologic diseases. This increase was not correlated with that of PGE2 levels, measured as an index of cyclooxygenase activity, and was much lower in steroid-treated patients. The levels of 8-epi-PGF2alpha were moderately correlated with the degree of disability.
Greco
A
A
Laboratory of Pathophysiology, Istituto Superiore di Santà University of Rome La Sapienza, Italy.
Minghetti
L
L
Sette
G
G
Fieschi
C
C
Levi
G
G
D000328:Adult; D000368:Aged; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid; D015232:Dinoprostone / Q000134:cerebrospinal fluid; D006233:Persons with Disabilities; D028441:F2-Isoprostanes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000378:metabolism* / Q000503:physiopathology; D009994:Osmolar Concentration; D018384:Oxidative Stress; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D012016:Reference Values
D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone