Inflammatory thoughts about glioma gene therapy.
Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256-1263).
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D000256:Adenoviridae / Q000235:genetics; D001932:Brain Neoplasms / Q000628:therapy*; D004660:Encephalitis / Q000209:etiology*; D015774:Ganciclovir / Q000627:therapeutic use; D015316:Genetic Therapy / Q000009:adverse effects*; D005822:Genetic Vectors; D005910:Glioma / Q000628:therapy*; D018259:Herpesvirus 1, Human / Q000201:enzymology; D006801:Humans; D013937:Thymidine Kinase / Q000235:genetics
D013937:Thymidine Kinase; D015774:Ganciclovir