Stabilization of microtubules by Combretastatin D derivatives.
The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active.
Couladouros
E A
EA
Chemistry Laboratories, Agricultural University of Athens, Greece. ecoula@mail.ariadne-t.gr
Li
T
T
Moutsos
V I
VI
Pitsinos
E N
EN
Soufli
I C
IC
D001632:Bibenzyls / Q000737:chemistry / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*; D015394:Molecular Structure; D013267:Stilbenes
D001632:Bibenzyls; D013267:Stilbenes; C040105:combretastatin