Histamine protects T cells and natural killer cells against oxidative stress.
Oxidative stress inflicted by monocytes/macrophages (MO) is recognized as an important immunosuppressive mechanism in human neoplastic disease. We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and natural killer (NK) cells, became anergic to the T cell and NK cell activator interleukin-2 (IL-2) after exposure to MO-derived reactive oxygen metabolites and subsequently acquired features characteristic of apoptosis. The MO-induced anergy and apoptosis in T cells and NK cells were reversed by histamine, an inhibitor of reactive oxygen metabolite synthesis in MO. We propose that strategies to circumvent oxidative inhibition of lymphocytes may be of benefit in immunotherapy of neoplastic disease.
Hansson
M
M
Department of Virology, University of Göteborg, Sweden.
Hermodsson
S
S
Brune
M
M
Mellqvist
U H
UH
Naredi
P
P
Betten
A
A
Gehlsen
K R
KR
Hellstrand
K
K
D015703:Antigens, CD / Q000097:blood; D000945:Antigens, Differentiation, T-Lymphocyte / Q000097:blood; D017209:Apoptosis / Q000187:drug effects; D019610:Cytoprotection; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000187:drug effects*; D037181:Lectins, C-Type; D008024:Ligands; D008264:Macrophages / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects*; D019014:fas Receptor / Q000097:blood; D000099192:CD69 Antigens
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D006632:Histamine; D037181:Lectins, C-Type; D008024:Ligands; D017382:Reactive Oxygen Species; D019014:fas Receptor; D000099192:CD69 Antigens