Studies on the synthesis and properties of new PNA analogs consisting of L- and D-lysine backbones.
Homopentamers of PNA consisting of L- and D-lysine were synthesized. It was found that the intramolecular hydrogen bonding has no significant influence on intermolecular interaction. These pentamers show a tendency to form complex with polyA in tris(pH 8.0) solution. The L-conformer has more potential than D-isomer.
Zhang
L
L
School of Pharmaceutical Sciences, Beijing Medical University, China.
Min
J
J
Zhang
L
L
D002942:Circular Dichroism; D006860:Hydrogen Bonding; D008239:Lysine / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D020135:Peptide Nucleic Acids; D008239:Lysine