title: Selective inhibition of low affinity IgE receptor (CD23) processing: P1' bicyclomethyl substituents.
abstract: Using a variety of alpha-hydroxy hydroxamic acid derivatives, the size and shape of the S1' pocket for the CD23 processing metalloprotease has been explored. It has been demonstrated that a P1' 2-naphthylmethyl group occupies most of the available space and gives excellent selectivity against fibroblast collagenase (matrix metalloproteinase-1, MMP-1) and other MMPs.
authors.affiliation: SmithKline Beecham Pharmaceuticals, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bailey
authors.forename: B
authors.initials: B
authors.lastname: Bolognese
authors.forename: A
authors.initials: A
authors.lastname: Faller
authors.forename: P
authors.initials: P
authors.lastname: Louis-Flamberg
authors.forename: D T
authors.initials: DT
authors.lastname: MacPherson
authors.forename: R J
authors.initials: RJ
authors.lastname: Mayer
authors.forename: L A
authors.initials: LA
authors.lastname: Marshall
authors.forename: P H
authors.initials: PH
authors.lastname: Milner
authors.forename: J
authors.initials: J
authors.lastname: Mistry
authors.forename: D G
authors.initials: DG
authors.lastname: Smith
authors.forename: J G
authors.initials: JG
authors.lastname: Ward
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D017455:Receptors, IgE / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D001643:Bridged Bicyclo Compounds; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D017455:Receptors, IgE