title: Hematologic abnormalities among HIV-infected patients: associations of significance for dentistry.
abstract: OBJECTIVE
  The purpose of this study was to determine the prevalence and severity of and the factors associated with peripheral blood cytopenias among HIV-infected patients.
  
  
  METHODS
  The investigation involved 516 HIV-infected adults in a longitudinal study of oral disease. Prevalence of hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, and platelet values below the lower limit of normal and certain hematologic "critical values" were determined. Demographic, clinical/immunologic/viral stage, medications, and oral lesions were assessed for association with cytopenias by chi(2) and bivariate analyses.
  
  
  RESULTS
  Findings with respect to prevalence were as follows: anemia, 51%; leukopenia, 43. 4%; neutropenia, 27.5%; lymphopenia, 20.7%; thrombocytopenia, 15.5%. Severe cytopenias were detected in fewer than 1% of the patients. Severity of HIV clinical disease and CD4 cell count depletion were significantly associated with all cytopenias. High viral load was associated only with the leukopenias. Black race, antiparasitic therapy, and some oral lesions were associated with certain cytopenias.
  
  
  CONCLUSIONS
  In HIV-infected patients, mild cytopenias are common; however, severe anemia, neutropenia, and thrombocytopenia that may predispose to certain oral manifestations and dental surgical complications are rare.
authors.affiliation: University of North Carolina at Chapel Hill, Department of Dental Ecology, NC 27599-7450, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Patton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology; D001772:Blood Cell Count; D016009:Chi-Square Distribution; D017742:Dental Care for Chronically Ill; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000150:complications*; D006402:Hematologic Diseases / Q000209:etiology*; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood / Q000209:etiology / Q000628:therapy; D016017:Odds Ratio; D013921:Thrombocytopenia / Q000209:etiology