title: Acute reversible cerebral arteritis associated with parenteral ephedrine use.
abstract: Cerebrovascular disorders in association with licit or illicit drugs have rarely been reported. We report a first case of stroke associated with the parenteral use of ephedrine. A 44-year-old woman underwent spinal anaesthesia for varicose vein surgery. She was usually treated with propranolol and occasionally with phenoxazoline. During anaesthesia, ephedrine was administered by the venous route because of arterial hypotension. She developed intracranial hypertension and focal cerebral deficits related to multiple haemorrhagic cerebral infarcts associated with a reversible beading appearance on angiography consistent with the diagnosis of acute cerebral arteritis. The role of ephedrine in this case is discussed beside other causes of acute cerebral arteritis.
authors.affiliation: Service de Neurologie, Hôpital Central, Centre Hospitalier Universitaire, Nancy, France.
authors.forename: I
authors.initials: I
authors.lastname: Mourand
authors.forename: X
authors.initials: X
authors.lastname: Ducrocq
authors.forename: J C
authors.initials: JC
authors.lastname: Lacour
authors.forename: L
authors.initials: L
authors.lastname: Taillandier
authors.forename: R
authors.initials: R
authors.lastname: Anxionnat
authors.forename: M
authors.initials: M
authors.lastname: Weber
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000009:adverse effects; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000139:chemically induced* / Q000175:diagnosis; D004809:Ephedrine / Q000009:adverse effects*; D005260:Female; D013700:Giant Cell Arteritis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007275:Injections, Intravenous; D013566:Sympathomimetics / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D013566:Sympathomimetics; D004809:Ephedrine