[The effect of captopril on cerebral blood flow in hypertensive rats before and after cerebral ischemia].
Acute experiments were conducted on narcotized hypertensive rats (vasorenal hypertension) to study the effect of captopril (5 mg/kg, intraperitoneal injection) on arterial pressure and cerebral blood flow and its autoregulation before and after transitory (10-12 min) ischemia of the brain (bilateral occlusion of the carotid arteries). Captopril normalized the arterial pressure, but changes in the cerebral blood flow proved to be insufficiently stable, particularly in the postischemic period. Normalization of autoregulation of the cerebral blood flow was noted. In captopril treatment the survival rate among rats with ischemia of the brain increased.
Adzhienko
L M
LM
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
D000208:Acute Disease; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006706:Homeostasis / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002216:Captopril