Apoptosis of glioma cells induced by the fibroblast growth factor inhibitor 1,3,6-naphthalenetrisulfonate.
Fibroblast growth factors (FGFs) are powerful angiogenic polypeptides that are involved in the autocrine growth stimulation of gliomas. We report here that addition to glioma cell cultures of 1,3,6-naphthalenetrisulfonate (NTS), an inhibitor of the mitogenic activity of FGFs, significantly enhanced apoptosis, as assessed by terminal deoxynucleotidyl transferase (TdT) assay. The pro-apoptotic effect of NTS was time-dependent. These findings suggest that FGF may play a pivotal role in the survival of glioma cells, and support a clinical interest of NTS as a leading compound for the development of new antitumorals.
Cuevas
P
P
Departamento de Investigación, Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain. pedro.cuevas@hrc.es
Reimers
D
D
Diaz
D
D
Lozano
R M
RM
Giménez-Gallego
G
G
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D020287:In Situ Nick-End Labeling; D009282:Naphthalenesulfonates / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured
C114532:1,3,6-naphthalenetrisulfonate; D009282:Naphthalenesulfonates; D005346:Fibroblast Growth Factors