Combining nefazodone and midazolam during ECT.
We report the case of a patient suffering from dysthymia. He underwent successful ECT treatment and was medicated with nefazodone and midazolam. Comparing the EEG and motor seizure duration in the periods with and without midazolam, no significant differences were recorded, but the dosage of thiopental and of succinylcholine had to be increased markedly after midazolam was discontinued (P < 0.05; ANOVA). This case indicates a substantial pharmacodynamic interaction between nefazodone, midazolam, thiopental, and succinylcholine.
Conca
A
A
Department of Psychiatry I, Regional Hospital Rankweil, Austria.
al-Dubai
Z
Z
König
P
P
Beraus
W
W
D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004347:Drug Interactions; D019263:Dysthymic Disorder / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000627:therapeutic use; D010879:Piperazines; D013390:Succinylcholine / Q000627:therapeutic use; D013874:Thiopental / Q000627:therapeutic use; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
D018687:Antidepressive Agents, Second-Generation; D006993:Hypnotics and Sedatives; D009467:Neuromuscular Depolarizing Agents; D010879:Piperazines; D014230:Triazoles; C051752:nefazodone; D013390:Succinylcholine; D013874:Thiopental; D008874:Midazolam