title: Immunohistochemistry applied to the study of bone marrow Gaucher's cells: a case report.
abstract: Gaucher's disease is frequently associated with immunologic abnormalities, e.g. hypergammaglobulinemia, polyclonal gammopathy and benign monoclonal gammopathy. A patient with Gaucher's disease and a selective accumulation of IgM k in Gaucher's cells without serum monoclonal gammopathies is described. The selective accumulation is detected by immunohistochemistry analysis performed on cryostat bone marrow biopsies.
authors.affiliation: Department of Haematology, University of Florence, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Alterini
authors.forename: L
authors.initials: L
authors.lastname: Rigacci
authors.forename: S
authors.initials: S
authors.lastname: Stefanacci
authors.forename: F
authors.initials: F
authors.lastname: Innocenti
authors.forename: V
authors.initials: V
authors.lastname: Santini
authors.forename: V
authors.initials: V
authors.lastname: Carrai
authors.forename: P
authors.initials: P
authors.lastname: Rossi Ferrini
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001854:Bone Marrow Cells / Q000276:immunology* / Q000473:pathology*; D001856:Bone Marrow Examination; D005260:Female; D005776:Gaucher Disease / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D007150:Immunohistochemistry
chemical_list: D015703:Antigens, CD; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains