[Prevalence of IgG antibodies against Cytomegalovirus in patients with angiographically demonstrated coronary atherosclerosis].
BACKGROUND
Over the past 25 years the potential role of herpesvirus and particularly Cytomegalovirus as a factor which contribute to atherogenesis, and more recently in restenosis, has been investigated.


OBJECTIVE
To determine the rate of Cytomegalovirus seropositivity in patients with angiographically demonstrated Coronary Artery Atherosclerosis.


METHODS
The subjects were all adult patients undergoing coronary angiography at the Hospital Virgen de la Salud, Toledo between February, 1997 and May, 1998. From each patient, blood was drawn and collected to be assayed. Also we collected the data from sex, age, classic risk factors for coronary artery disease (hypertension, hypercholesterolemia, diabetes and cigarette smoking) and catheterization. Data from 437 patients who underwent cardiac catheterization were collected. There was 349 (82.3%) patients who underwent catheterization because of Ischemic Heart Disease. SEROLOGIC ASSAYS: Serum IgG antibodies to cytomegalovirus were measured quantitatively with EIA, VIDAS, (bioMérieux). As recommended by the manufacturer a titer over 6 was considered positive.


RESULTS
There was 115 female and 319 males. Patients were 24-86 years old. Data from catheterization showed that 113 patients (26%) have no lesions on coronaryography and 321 patients (74%) have Coronary Artery Disease (CAD). The rate of Cytomegalovirus-seropositive was 97.1% in patients with lesions and 98.2% in those without lesions.


CONCLUSIONS
There is a high rate of antibodies positive for Cytomegalovirus in the population, in patients with Ischemic Heart Disease and with coronary artery disease as in those without lesions in the coronarigraphy. Our conclusion is that if Cytomegalovirus could have any role in the building of proliferating ateheromas and in view of seroepidemiological studies some other factors must be implicated in the development of plaque growth.
Sepúlveda
M A
MA
Servicio de Cardiología, Hospital Virgen de la Salud, Toledo. maria.sepulveda@jet.es
Moreu
J
J
Cantón
T
T
Pajin
F
F
Rodríguez
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000032:analysis*; D003324:Coronary Artery Disease / Q000821:virology*; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G