title: Bone architecture and image synthesis.
abstract: 3-D bone architecture can now be measured by micro-computer tomography or micro-magnetic resonance imaging. The principles of the micro-computer technique is reviewed and new architectural parameters can be computed. In addition, the method allows the contruction of polymer models by stereolithography, a method that can be used to perform repetitive mechanical studies on the same bone sample. These non destructive methods are interesting in the pre-clinical studies on bone diseases and in the investigation of animal trials on new pharmacological compounds active on bone.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, Ohio 45040, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Gross
authors.forename: T E
authors.initials: TE
authors.lastname: Dufresne
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: M D
authors.initials: MD
authors.lastname: Cockman
authors.forename: P A
authors.initials: PA
authors.lastname: Chmielewski
authors.forename: K S
authors.initials: KS
authors.lastname: Combs
authors.forename: B
authors.initials: B
authors.lastname: Borah
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology*; D005289:Ferrets / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D051381:Rats / Q000033:anatomy & histology*