In vitro evaluation of erythromycin in chloroquine resistant brazilian P. falciparum freshly isolates: modulating effect and antimalarial activity evidence.
Erythromycin, a reversal agent in multidrug-resistant cancer, was assayed in chloroquine resistance modulation. The in vitro microtechnique for drug susceptibility was employed using two freshly isolates of Plasmodium falciparum from North of Brazil. The antimalarial effect of the drug was confirmed, with an IC50 estimates near the usual antimicrobial therapy concentration, and a significant statistical modulating action was observed for one isolate.
Menezes
C M
CM
Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, SP, Brasil.
Kirchgatter
K
K
Di Santi
S M
SM
Savalli
C
C
Monteiro
F G
FG
Paula
G A
GA
Ferreira
E I
EI
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001938:Brazil; D002738:Chloroquine / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004917:Erythromycin / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification
D000962:Antimalarials; D004917:Erythromycin; D002738:Chloroquine