Occupational risk factors in Parkinson's disease.
BACKGROUND
An apparent excess of teachers and healthcare workers among the Parkinson's disease patients of a large tertiary care movement disorders clinic suggested the hypothesis that high exposure to viral (or other) respiratory infections in these occupations might be a risk factor for Parkinson's disease.


METHODS
A case-control study of the association between occupation and Parkinson's disease was conducted. Cases (414) were all Parkinson's disease patients seen at the University of British Columbia Hospital Movement Disorders Clinic between 1986 and 1993, residing in Greater Vancouver, and under 65 in 1991. Controls (6,659) were randomly selected from the 1991 Canadian Census.


RESULTS
Parkinson's disease was associated with teaching (OR 2.50, 95% CI 1.67-3.74) and occupation in healthcare services (OR 2.07, 95% CI 1.34-3.20), but there were several other substantial associations, both positive and negative.


CONCLUSIONS
While referral bias cannot be ruled out, the authors find the consistency of the overall pattern of associations with the respiratory infection hypothesis striking.
Tsui
J K
JK
Department of Medicine, University of British Columbia, Vancouver.
Calne
D B
DB
Wang
Y
Y
Schulzer
M
M
Marion
S A
SA
D000293:Adolescent; D000328:Adult; D001955:British Columbia / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D009790:Occupations; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology*; D012307:Risk Factors; D018709:Statistics, Nonparametric