Design, synthesis and DNA-cleavage of Gly-Gly-His-naphthalene diimide conjugates.
Naphthalene diimides with one and two metal-chelating Gly-Gly-His (GGH) motifs have been synthesized. Both conjugates induce single-stranded cleavage of plasmid pBR322 DNA in the presence of nickel and Oxone and are approximately 100-fold more efficient than Ni(II) x GH-CONH2 itself.
Steullet
V
V
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta 30303, USA.
Dixon
D W
DW
D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D006868:Hydrolysis; D007094:Imides; D009281:Naphthalenes; D009842:Oligopeptides / Q000737:chemistry*; D010618:Phenanthrolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010957:Plasmids
D007094:Imides; D009281:Naphthalenes; D009842:Oligopeptides; D010618:Phenanthrolines; C542131:naphthalenediimide; C037026:diglycyl-histidine; D004247:DNA