Acquired amegakaryocytic thrombocytopenic purpura (AATP): a hospital based study.
OBJECTIVE
To determine the frequency of Acquired Amegakaryocytic Thrombocytopenic Purpura (AATT), possible aetiology, course and prognosis.


METHODS
Retrospectively diagnosed patients, treated and followed prospectively.


METHODS
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi.


METHODS
One hundred twenty patients with thrombocytopenic purpura.


METHODS
Response to treatment and course of disease.


RESULTS
Out of 22 patients 2 died of cerebral haemorrhage, one transformed to Myelodysplastic Syndrome (MDS), one transformed to Acute Myeloid Levkaenia (AML). None is transfusion independent.


CONCLUSIONS
AATT is not an infrequent disorder. It shows poor response to all available therapeutic modalities and has a potential for transformation into Myelodysplasia and acute myeloid leukaemia.
Zafar
T
T
Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi.
Yasin
F
F
Anwar
M
M
Saleem
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D011379:Prognosis; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome