title: Experimental animal myopia models are applicable to human juvenile-onset myopia.
abstract: Landmark explorations by Hubel and Wiesel investigating the importance of visual impressions in postnatal development of the visual system demonstrated that neural connections and eye growth can be affected by the absence of a clear retinal image during a critical period of postnatal development. Fundamental theories on neural plasticity and deprivation have recently been established that presume that a reduced quality of the retinal image during infancy and early childhood triggers an elongation of the posterior chamber of the eye, a so-called form deprivation myopia (FDM). In a retrospective multicenter study of 187 patients who suffered from phlyctenular keratitis with corneal opacification since early childhood, we reviewed data on gender, year and age at onset of the disease, refraction, and ultrasound biometry. Compared with the average refraction of +0.5 diopter (D) found in the general population, the mean refraction of -4.43 D that we found in our study demonstrated a marked shift toward myopia of almost 5 D. Patients with an early onset of phlyctenular keratitis had considerably higher myopia (-6.68 D) than those with a late onset (-1.67 D). Additionally, an axial elongation was confirmed by ultrasound biometry. Our average, axial length was 26.53 mm, compared with the epidemiologic mean of 24.00 mm. This myopic shift of 2.53 mm was caused mainly by an enlarged vitreous cavity. These results support the finding that blur can affect eye growth and lead to FDM not only in animal experiments but also in human beings.
authors.affiliation: Department of Ophthalmology, Medical University, Lübeck, Germany. meyer027@mc.duke.edu
authors.forename: C
authors.initials: C
authors.lastname: Meyer
authors.forename: M F
authors.initials: MF
authors.lastname: Mueller
authors.forename: G I
authors.initials: GI
authors.lastname: Duncker
authors.forename: H J
authors.initials: HJ
authors.lastname: Meyer
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002386:Cataract / Q000150:complications; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007634:Keratitis / Q000150:complications; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000453:epidemiology / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D012029:Refraction, Ocular; D012189:Retrospective Studies; D012683:Sensory Deprivation / Q000502:physiology; D014785:Vision, Ocular / Q000502:physiology