[Treatment of cancer ascites by combined intraperitoneal administration of low-dose CDDP and reinfusion of ultra-filtrated and concentrated ascitic fluid in patients].
Ascites due to carcinomatous dissemination is a severe problem for end-stage cancer patients. We attempted treating patients on an outpatient basis with the administration of low-dose CDDP-i.p. and reinfusion of ultrafiltrated and concentrated ascites. From 1995, we performed this therapy on 16 patients with concentrated ascites 6-8 fold and reinfusion, combined with low-dose CDDP-i.p. and drip infusion of 5-FU intravenously. The ascitic fluid was significantly decreased after treatment in 8 patients, and 2 patients had lasting low concentrations of CA 125. CA 125 decreased in 83.3% of patients, who tended to have extended survival times after remarkable ascites pooling and treatment with low-dose CDDP-i.p. and reinfusion therapy. This treatment is a useful cant method for decreasing ascites and improving QOL.
Takahashi
Y
Y
Dept. of Surgery, Gifu Prefectural Hospital.
Imai
H
H
Ikawa
A
A
Yasuda
K
K
Kawai
M
M
Yamamori
T
T
Furuichi
N
N
Misawa
K
K
Ohashi
H
H
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001202:Ascitic Fluid / Q000188:drug therapy* / Q000209:etiology; D002945:Cisplatin / Q000008:administration & dosage*; D003110:Colonic Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications; D014462:Ultrafiltration
D000970:Antineoplastic Agents; D002945:Cisplatin