title: Pleural and pericardial effusion as the first sign of multiple myeloma.
abstract: We report a case of IgA-kappa multiple myeloma in a 68-year-old woman that was revealed by concomitant pleural and pericardial effusion. These effusions were found to be caused by myeloma and were verified by cytological examination of the pleural fluid and pericardial biopsy. The patient had neither osteolytic lesions nor Bence-Jones proteinuria. After a pericardiocentesis, her condition improved with a melphalan and prednisolone treatment. As far as we know, such a phenomenon is rare and has never been reported yet as a way of diagnosing multiple myeloma.
authors.affiliation: Department of Internal Medicine, University Hospital of Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: André
authors.forename: J
authors.initials: J
authors.lastname: Ponsonnaille
authors.forename: J L
authors.initials: JL
authors.lastname: Kemeny
authors.forename: M
authors.initials: M
authors.lastname: Filaire
authors.forename: P
authors.initials: P
authors.lastname: Travade
authors.forename: O
authors.initials: O
authors.lastname: Aumaitre
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000188:drug therapy; D010490:Pericardial Effusion / Q000175:diagnosis / Q000209:etiology*; D010996:Pleural Effusion / Q000175:diagnosis / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D013902:Radiography, Thoracic; D013997:Time Factors
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone; D008558:Melphalan