Local hemostatic effects of microcrystalline partially deacetylated chitin hydrochloride.
The hemostatic effects of microcrystalline partially deacetylated chitin hydrochloride (DAC-HCl) were compared with those of cotton and collagen hydrochloride (collagen-HCl). The DAC-HCl had excellent physical properties as a hemostatic agent such as its ability to absorb and retain blood. In canine blood it induced the release of substances involved in the process of platelet activation, such as beta-thromboglobulin and platelet factor 4, and it also had excellent hemoagglutinative properties. Moreover, in a hemostatic study on bleeding from cancellous bone in canines it exhibited a hemostatic effect comparable to that exhibited by collagen-HCl. Because it also has an intrinsic promotive effect on wound healing, chitin hydrochloride is considered to be a promising hemostatic material.
Sugamori
T
T
Department of Orthopaedic Surgery, Juntendo University Medical Department, 3-7-8-103 Nakarokugo Ota-Ku, Tokyo 144-0055, Japan.
Iwase
H
H
Maeda
M
M
Inoue
Y
Y
Kurosawa
H
H
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry; D002686:Chitin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry*; D004285:Dogs; D006487:Hemostasis / Q000187:drug effects*; D015539:Platelet Activation / Q000187:drug effects
D001672:Biocompatible Materials; D002686:Chitin