title: What is the oxygen environment under an encapsulated segment bifocal RGP contact lens?
abstract: BACKGROUND
  A bifocal rigid gas permeable (RGP) contact lens is now available that totally encapsulates an add segment of a different material within its inferior aspect. The purposes of this study were to determine the effects of the major lens and of its encapsulated segment region on the oxygen uptake rates of underlying cornea.
  
  
  METHODS
  Corneal oxygen uptake rates of 10 human corneas were measured--both centrally and inferiorly--for non-wearing conditions and then immediately after 300-second wearing periods of a polymethylmethacrylate (PMMA) lens and of this RGP-encapsulated segment bifocal contact lens. Corneal responses associated with these three environmental conditions were compared statistically (i.e., without the influence of blink-driven tear flow).
  
  
  RESULTS
  Under the nonblinking conditions maintained (i.e., with oxygen availability restricted to lens transmissibility alone), central corneal hypoxia was found for the RGP bifocal lens to be only 47% of that induced by the PMMA (Dk/L = 0) condition, while the cornea under the encapsulated segment of the bifocal lens averaged 78% of the hypoxic response induced by that same condition. Central site responses were found to be significantly different for the bifocal and the PMMA lens (p < 0.001), as they were for the two inferior sites with these two lenses (p < 0.001). All lens-related responses were found to be significantly different from the no lens condition (p < 0.001).
  
  
  CONCLUSIONS
  Using Smith's model (JAOA, 1997) to estimate lens transmissibility, the major lens of this RGP bifocal design appears to meet approximately 80% of the Holden-Mertz daily-wear oxygen requirement--even without post-lens tear exchange, but only about 25% of that requirement appears to be met beneath the encapsulated segment region. Efficient supplementary infusion of oxygen under this lens by blink-driven tear exchange, then, is necessary to maintain optimal corneal health.
authors.affiliation: Ohio State University, College of Optometry, Columbus, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Brunstetter
authors.forename: B A
authors.initials: BA
authors.lastname: Fink
authors.forename: R M
authors.initials: RM
authors.lastname: Hill
mesh_terms: D000328:Adult; D003262:Contact Lenses, Extended-Wear; D003315:Cornea / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D055095:Optics and Photonics; D010100:Oxygen / Q000378:metabolism*; D019904:Polymethyl Methacrylate; D011305:Presbyopia / Q000378:metabolism / Q000628:therapy
chemical_list: D019904:Polymethyl Methacrylate; D010100:Oxygen