New scalaranes from the nudibranch Glossodoris atromarginata and its sponge prey.
Two new scalaranes (1 and 2) have been isolated from the dorid nudibranch Glossodoris atromarginataand its prey. The structures were deteremined by spectral techniques and confirmed by chemical methods. Compounds 1 and 3 showed selective cytotoxic activity against human thyroid carcinoma.
Fontana
A
A
Istituto per la Chimica di Molecole di Interesse Biologico (ICMIB)(1) del CNR, Via Toiano 6, 80072 Arco Felice, Napoli, Italy. font@trinc.icmib.na.cnr.it
Cavaliere
P
P
Ungur
N
N
D'Souza
L
L
Parameswaram
P S
PS
Cimino
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013964:Thyroid Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes