Epidemiology of primary CNS lymphoma.
In the beginning of the nineties the National Cancer Institute Surveillance, Epidemiology, and End Results Program calculated the incidence of primary central nervous system non-Hodgkin's lymphoma (PCNSL) as 1:100000. The incidence of PCNSL has been increasing since the seventies in immunocompetent patients. The main increase, however, is taking place since the mid-eighties and is due to the increase of immunodeficiency and immunosuppression. The risk is 2-6% in AIDS patients according to clinical data and will probably further increase with the length of survival in these patients. Transplant patients carry a risk of 1-5% to develop a PCNSL. The risk is 1-2% for renal, and 2-7% for cardiac, lung or liver transplant recipients. Patients with congenital immune deficiency have a risk of 4%. PCNSL may also present as a secondary malignancy.
Schabet
M
M
Department of Neurology, University of Tuebingen, Germany. martin.schabet@dgn.de
D016543:Central Nervous System Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology*; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology*; D008297:Male; D012307:Risk Factors; D014180:Transplantation / Q000009:adverse effects