title: The development and applications of thermal biosensors for bioprocess monitoring.
abstract: Enzyme thermistors are biosensors that use thermal resistors to measure the heat change caused by an enzymatic reaction. They combine the selectivity of enzymes with the sensitivity of biosensors and allow continuous analysis in a flow-injection mode. They can be used to monitor fermentation systems, biocatalysis, enzyme-catalysed synthesis and clinical and food technology. This article gives an overview of the general principles of enzyme thermistors, the sampling process and the ongoing developments in the field of bioprocess monitoring.
authors.affiliation: Department of Pure and Applied Biochemistry, Box 124, Centre for Chemistry and Chemical Engineering, Lund University, S-221 00 Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Ramanathan
authors.forename: M
authors.initials: M
authors.lastname: Rank
authors.forename: J
authors.initials: J
authors.lastname: Svitel
authors.forename: A
authors.initials: A
authors.lastname: Dzgoev
authors.forename: B
authors.initials: B
authors.lastname: Danielsson
mesh_terms: D001331:Automation; D015374:Biosensing Techniques; D001709:Biotechnology / Q000295:instrumentation*; D002384:Catalysis; D004798:Enzymes; D005285:Fermentation; D005524:Food Technology; D008991:Monitoring, Physiologic / Q000295:instrumentation; D013696:Temperature
chemical_list: D004798:Enzymes