title: Protective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy.
abstract: Thirty-four adult patients with untreated periodontitis were randomly assigned to receive full mouth scaling alone or scaling with an adjunctive antimicrobial therapy, both followed by supportive periodontal therapy. At 24 months, specific serum immunoglobulin A (IgA), IgG and IgG subclass antibody reactivities against a 110-kDa protein of Actinobacillus actinomycetemcomitans were assessed by Western blot. In patients harboring A. actinomycetemcomitans intraorally, the IgG4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans was associated with significantly increased survival rates of teeth and of sites not exhibiting 2 mm or more of probing attachment loss. The same trend was found for IgG3 and IgG2 antibody reactivities, but it was statistically insignificant. No association with clinical treatment outcome was observed for IgA, IgG and IgG1 antibody reactivities. The results indicated that systemic IgG4 antibody reactivity against the 110-kDa protein of A. actinomycetemcomitans may have a protective effect against periodontal disease progression in patients harboring A. actinomycetemcomitans and receiving periodontal therapy.
authors.affiliation: Department of Periodontology, Julius Maximilians University, Würzburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Beikler
authors.forename: H
authors.initials: H
authors.lastname: Karch
authors.forename: B
authors.initials: B
authors.lastname: Ehmke
authors.forename: B
authors.initials: B
authors.lastname: Klaiber
authors.forename: T F
authors.initials: TF
authors.lastname: Flemmig
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000276:immunology*; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D012534:Dental Scaling; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D008970:Molecular Weight; D010406:Penicillins / Q000627:therapeutic use; D010518:Periodontitis / Q000097:blood / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; C010882:chlorhexidine gluconate; D002710:Chlorhexidine