title: [Treatment of solid tumor by a direct electric current].
abstract: This is a case report of a 37-year-old Japanese married female with laryngeal sarcoma, treated by direct electric current so as to obtain remission for more than 4 years without signs of recurrence. Due to her hoarseness and laryngeal numb feeling she underwent a laryngeal examination including a biopsy, resulting in a diagnosis of sarcoma. She refused a total laryngectomy and was given Cobalt treatment of 40 Grey. In the following several months, no improvement was observed, objectively or subjectively. In Nagoya University Hospital the patient then received direct electric current therapy of 36 Coulombs through two platinum electrodes inserted into the tumor under a CT guide, pericutaneously. Two months later, as the hoarseness remained in spite of some improvement, she underwent another session of direct electric current therapy of 14.4 Coulombs through the platinum electrodes by bronchoscope-guided direct insertion. Her hoarseness soon disappeared thereafter and there was a regression of the tumor in 6 months. She did well thereafter without any signs of recurrence for 4 years. Clinical treatment of solid tumors with electric treatment with direct electric current has been done in more than 8,000 cases with CR in 25% of all cases and PR in 50%. Its mechanism, however, remains unclear. In our experimental animal studies, apoptosis was observed. It is considered that this electric therapy using direct electric current will be recognized as one method to treat solid tumors.
authors.affiliation: Dept. of Surgery II, Nagoya University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Hidemura
authors.forename: H
authors.initials: H
authors.lastname: Tsunoo
authors.forename: S
authors.initials: S
authors.lastname: Suda
authors.forename: Y
authors.initials: Y
authors.lastname: Kanemitsu
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Chin
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Sekiguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kasai
authors.forename: S
authors.initials: S
authors.lastname: Akiyama
authors.forename: A
authors.initials: A
authors.lastname: Nakao
mesh_terms: D000328:Adult; D004599:Electric Stimulation Therapy / Q000379:methods; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy*; D012074:Remission Induction; D012509:Sarcoma / Q000628:therapy*