[Effect of an infections dose of the Ebola virus on survivability and immunologic indicators in guinea pigs].
Analysis of the time course of immunological parameters in intact guinea pigs and animals immunized with inactivated Ebola virus (EV) inoculated with high and low doses of EV strain lethal for guinea pigs showed that high doses induced a higher resistance of the lymphocytic component of immunity than low doses, but activation of the neutrophil phagocytosis was far less expressed after high doses than after low ones. This indicates a qualitative effect of the infective dose of EV on the development of immunological reactions in animals, which modifies the ratio between the lymphocytic and neutrophilic components of immunity.
Dadaeva
A A
AA
Chepurnov
A A
AA
Sizikova
L P
LP
Chepurnova
T S
TS
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D029043:Ebolavirus / Q000472:pathogenicity*; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology* / Q000401:mortality*; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D014765:Viral Vaccines / Q000008:administration & dosage*
D014765:Viral Vaccines