title: Effects of clozapine on psychiatric symptoms, cognition, and functional outcome in schizophrenia.
abstract: This study focused on the symptomatic and cognitive effects of the atypical antipsychotic clozapine in chronic hospitalized schizophrenia patients. Further, it explored how these effects might be related to discharge, an important functional outcome. Patients were assessed at baseline and at regular intervals with clinical instruments and a cognitive battery. Clozapine treatment produced symptomatic and cognitive improvements, positive changes that appeared to occur independently of one another. Baseline cognitive performance, as well as cognitive change with treatment, predicted discharge. Further investigation of the effects of clozapine and other atypical antipsychotics on cognition and functional outcome is warranted.
authors.affiliation: Department of Psychiatry, Harvard Medical School, Fall River, MA 02720, USA. tmanschreck@state.ma.us
authors.forename: T C
authors.initials: TC
authors.lastname: Manschreck
authors.forename: D A
authors.initials: DA
authors.lastname: Redmond
authors.forename: S F
authors.initials: SF
authors.lastname: Candela
authors.forename: B A
authors.initials: BA
authors.lastname: Maher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D002908:Chronic Disease; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy* / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine