title: [Prevention of infection in war wounds].
abstract: Medical treatment of injured patients by international missions of non-governmental organisations in crisis areas and out-of-area operations by troops, and also national disasters require special trauma management. Deviations from peacetime surgical guidelines are obligatory because of long-distance medical evacuation, the possibility of gaps in supply and the typical pattern of war injuries. Massive contamination combined with the high risk of infection is one typical attribute of wounds inflicted during a war or a disaster. In contrast to peacetime surgical guidelines, aggressive wound débridement is often needed. Timely and prophylactically prescription of a broad-spectrum antibiotic with a long half-life has great importance in the treatment of these wounds. Suitable antibiotics for these indications are: piperacillin/tazobactam and ceftriazon. Nevertheless the use of antimicrobial agents will only be effective with early surgical débridement.
authors.affiliation: Chirurgische Abteilung, Bundeswehrkrankenhaus, Berlin.
authors.forename: R
authors.initials: R
authors.lastname: Czymek
authors.forename: S
authors.initials: S
authors.lastname: Lenz
authors.forename: W
authors.initials: W
authors.lastname: Düsel
mesh_terms: D019072:Antibiotic Prophylaxis; D001753:Blast Injuries / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D017410:Practice Guidelines as Topic; D000078142:Tazobactam; D014857:Warfare; D014946:Wound Infection / Q000517:prevention & control*; D014948:Wounds, Gunshot / Q000601:surgery*
chemical_list: D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin