The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity.
Human lymphocyte antigen (HLA) associations are recognized for many autoimmune diseases, but the mechanisms are not clear. Goodpasture's disease provides a unique opportunity to investigate possible mechanisms because strong HLA associations are known, the autoantigen is well defined, and major antigen-derived peptides presented bound to HLA molecules have been identified. Therefore, it may be possible to directly analyze interactions between the antigen and HLA molecules associated with the disease, and to examine influences on antigen presentation to T cells. Towards this goal, we present a detailed analysis of HLA associations with the disease and examine molecular mechanisms that could account for them.
Phelps
R G
RG
Department of Renal Medicine, University of Edinburgh, Royal Infirmary, Edinburgh EH3 9YW, United Kingdom. richard.phelps@ed.ac.uk
Rees
A J
AJ
D000483:Alleles; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology*; D015551:Autoimmunity; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000502:physiology*; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D006801:Humans; D010641:Phenotype; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II