Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.
Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 microg/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 microg/mL, respectively.
Ohyama
M
M
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
Tanaka
T
T
Ito
T
T
Iinuma
M
M
Bastow
K F
KF
Lee
K H
KH
D000085:Acetates; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000085:Acetates; D001704:Biopolymers; D013267:Stilbenes; D000077185:Resveratrol