title: Structural analyses of a precursory substance of bitterness: new polyisoprenepolyols isolated from an edible mushroom (Hypsizigusmarmoreus) by fast atom bombardment mass spectrometry.
abstract: New polyisoprenepolyols (hypsiziprenol AA and BA) were isolated from an edible mushroom (Hypsizigus marmoreus). These polyols occur as a mixture of homologous polyisoprene derivatives with 40-70 carbon atoms. Analyses by FAB/MS in the positive and negative ion modes are complementary with each other in that the former provides information on the number of hydroxy groups present while the latter specifies the isoprenoid sequence, and thus become a powerful tool for analyzing the structures of polyisoprenepolyols. No polyisoprenepolyols obtained here were found to have antitumor activity on NCI-H292 and EL-4 cell lines.
authors.affiliation: Institute for Comprehensive Agricultural Sciences and Faculty of Agriculture, Kinki University, Nara, Japan. sawabe@nara.kindai.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Sawabe
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: T
authors.initials: T
authors.lastname: Kiso
authors.forename: H
authors.initials: H
authors.lastname: Kishine
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsubo
authors.forename: S
authors.initials: S
authors.lastname: Ouchi
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013649:Taste; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005233:Fatty Alcohols; D007202:Indicators and Reagents; D013729:Terpenes