Successful liver transplantation from a donor with brodifacoum intoxication.
We describe our use of a liver allograft from a donor who died of intracranial hemorrhage after brodifacoum ingestion. Because brodifacoum can remain in the human body for months, the recipient's posttransplantation coagulation profiles and serum brodifacoum levels were monitored closely. Her posttransplantation course was excellent, with no coagulation problem. At 15 months posttransplantation, she is well, with normal liver function and coagulation profile. We conclude that brodifacoum toxicity is not a strict contraindication to liver donation.
Emre
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The Recanati/Miller Transplantation Institute, The Mount Sinai Medical Center, New York, NY 10029-6574, USA.
Kitabayashi
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Miller
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CM
D015110:4-Hydroxycoumarins / Q000506:poisoning*; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012378:Rodenticides / Q000506:poisoning*; D014019:Tissue Donors; D009927:Tissue and Organ Procurement
D015110:4-Hydroxycoumarins; D012378:Rodenticides; C013418:bromfenacoum