Aspects of fetal thyroid dose following iodine-131 administration during early stages of pregnancy in patients suffering from benign thyroid disorders.
Detrimental effects on the thyroid of the developing fetus as a result of iodine-131 treatment for thyrotoxicosis of the mother in the first trimester of pregnancy are discussed. Dose estimations under typical clinical circumstances yield a fetal thyroid dose of 100- 450 Sv. This dose may increase considerably if the blood concentration of (131)I in the mother remains high. Under such circumstances there may be fetal thyroid dysfunction, which can lead to severe abnormalities.
Pauwels
E K
EK
Division of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Thomson
W H
WH
Blokland
J A
JA
Schmidt
M E
ME
Bourguignon
M
M
El-Maghraby
T A
TA
Broerse
J J
JJ
Harding
L K
LK
D000016:Abnormalities, Radiation-Induced / Q000517:prevention & control; D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000532:radiotherapy*; D011829:Radiation Dosage; D011835:Radiation Protection; D011874:Radiometry; D013959:Thyroid Diseases / Q000532:radiotherapy*; D013961:Thyroid Gland / Q000196:embryology / Q000528:radiation effects*
D007457:Iodine Radioisotopes