title: Evaluation of serum-lipid-related cardiovascular risk factors in Alzheimer's disease.
abstract: There is now sufficient evidence to suggest that cardiovascular pathology and altered lipid metabolism contribute to the development of late-onset Alzheimer's disease (AD). In the present study, 24 AD patients and 15 controls were assessed for cardiovascular risk based on serum lipid and lipid oxidation parameters. The AD patients appeared to have a more favorable cardiovascular risk profile than the controls based on high-density lipoprotein cholesterol (HDL-C) values. The levels of thiobarbituric-acid-reactive substances and the activity of the enzyme paraoxonase (PON) following copper oxidation indicate that female patients may have better protection against serum and perhaps tissue oxidants than males with AD. While the higher HDL-C values indicate lower cardiovascular risk, additional data on oxidized lipid parameters suggest a lower level of protection against serum oxidants in male AD probands. CopyrightCopyright 1999S.KargerAG,Basel
authors.affiliation: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2644, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kálmán
authors.forename: B J
authors.initials: BJ
authors.lastname: Kudchodkar
authors.forename: K
authors.initials: K
authors.lastname: Murray
authors.forename: W J
authors.initials: WJ
authors.lastname: McConathy
authors.forename: A
authors.initials: A
authors.lastname: Juhász
authors.forename: Z
authors.initials: Z
authors.lastname: Janka
authors.forename: A G
authors.initials: AG
authors.lastname: Lacko
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D043303:Aryldialkylphosphatase; D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood; D004950:Esterases / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012307:Risk Factors; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008054:Lipid Peroxides; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D004950:Esterases; D043303:Aryldialkylphosphatase