title: New pyrrole derivatives as antimycobacterial agents analogs of BM212.
abstract: During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2-6 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Rome, Italy. Biava@axrma.uniroma1.it
authors.forename: M
authors.initials: M
authors.lastname: Biava
authors.forename: R
authors.initials: R
authors.lastname: Fioravanti
authors.forename: G C
authors.initials: GC
authors.lastname: Porretta
authors.forename: D
authors.initials: D
authors.lastname: Deidda
authors.forename: C
authors.initials: C
authors.lastname: Maullu
authors.forename: R
authors.initials: R
authors.lastname: Pompei
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D010879:Piperazines; D011758:Pyrroles; C115651:BM 212