title: The effect of one injection of Depo-Provera on the human vaginal epithelium and cervical ectopy.
abstract: Two studies in rhesus monkeys have shown that progesterone implants, Depo-Provera and Norplant, were associated with vaginal thinning. Progesterone implants have also been associated with an increased risk of simian immunodeficiency virus (SIV) acquisition. This study in 16 women was done to assess vaginal epithelial thickness and number of cell layers from biopsies taken in the untreated follicular and luteal phases, and at 1 month and 3 months after administration of Depo-Provera. There was no significant change over time in either parameter from biopsies obtained in the luteal phase compared with those at either time after Depo-Provera administration. There was also no change in the mean number of Langerhans cells in vaginal wall specimens and no change in cervical ectopy. It appears that women do not respond to exogenous progestins with the dramatic vaginal thinning seen in rhesus monkeys.
authors.affiliation: Contraceptive Research and Development Program (CONRAD), Arlington, Virginia 22209, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Mauck
authors.forename: M M
authors.initials: MM
authors.lastname: Callahan
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: K
authors.initials: K
authors.lastname: Arbogast
authors.forename: R
authors.initials: R
authors.lastname: Veazey
authors.forename: R
authors.initials: R
authors.lastname: Stock
authors.forename: Z
authors.initials: Z
authors.lastname: Pan
authors.forename: C S
authors.initials: CS
authors.lastname: Morrison
authors.forename: M
authors.initials: M
authors.lastname: Chen-Mok
authors.forename: D F
authors.initials: DF
authors.lastname: Archer
authors.forename: H L
authors.initials: HL
authors.lastname: Gabelnick
mesh_terms: D000328:Adult; D001706:Biopsy; D001835:Body Weight; D002584:Cervix Uteri / Q000187:drug effects* / Q000473:pathology; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000627:therapeutic use*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007273:Injections, Intramuscular; D007801:Langerhans Cells / Q000187:drug effects; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008597:Menstrual Cycle; D010781:Photography; D011374:Progesterone / Q000097:blood; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D014621:Vagina / Q000187:drug effects* / Q000473:pathology
chemical_list: D003271:Contraceptive Agents, Female; D011374:Progesterone; D004958:Estradiol; D017258:Medroxyprogesterone Acetate