Different vascular patterns of medulloblastoma and supratentorial primitive neuroectodermal tumors.
Astrocytoma vasculature patterns differ according to histological grade of malignancy with glioblastoma multiforme (WHO grade IV) showing most extensive endothelial proliferation. Here, we determined whether the vascular patterns of medulloblastoma and supratentorial primitive neuroectodermal tumors (PNETs), which can be hardly distinguished histopathologically, differ. We evaluated the spatial organization of vessels in medulloblastomas and PNETs using antibodies to von Willebrand factor (vWF) and CD34. Medulloblastoma capillaries showed slight endothelial cell hyperplasia. Microvessels sprouted from the capillaries and formed glomeruloid clusters. There were areas with chains of unopposed endothelial cells (3-10 cells). Supratentorial PNETs had highly branched capillaries with extensive endothelial cell hyperplasia. Glomeruloid arrays of microvessels extended from the capillaries. Small fragments of endothelial tubes were scattered throughout the tumor. Therefore, medulloblastomas and supratentorial PNETs showed different spatial organization of tumor vessels which can be used for differentiation of each tumor entity. These vascular patterns may reflect different tumor derived angiogenic stimuli.
Goldbrunner
R H
RH
Department of Neurosurgery, University of Wuerzburg, Germany. goldbrunner@mail.uni.wuerzburg.de
Pietsch
T
T
Vince
G H
GH
Bernstein
J J
JJ
Wagner
S
S
Hageman
H
H
Selby
D M
DM
Krauss
J
J
Soerensen
N
N
Tonn
J C
JC
D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor; D002528:Cerebellar Neoplasms / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000098:blood supply*; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000098:blood supply*; D015173:Supratentorial Neoplasms / Q000098:blood supply*; D014841:von Willebrand Factor / Q000032:analysis
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014841:von Willebrand Factor