High-Fat diet enhances accumulation of hexachlorobenzene in rat dams and delays its transfer from rat dams to suckling pups through milk.
Effect of diets on the distribution and transfer of hexachlorobenzene (HCB) from dams to fetuses and suckling pups was investigated. In pregnant rats, the amount of HCB accumulated in fat tissues of the high-fat diet group was higher than that of the control diet group (P < 0.05). The amounts of HCB in fetuses of the high-fat and control diet groups were estimated to be about 0.28 and 0.12% of the dam's total intake during pregnancy, respectively. In both groups, a large proportion of HCB in dams disappeared during lactation period and was transferred to their pups through the milk. In the pups of the high-fat diet group, the amount of HCB in stomach contents was lower immediately after birth and decreased slowly compared with that in the control diet group during lactation. These results showed that a high-fat diet reduced the speed of the transfer of HCB from the dams to their suckling pups through milk.
Nakashima
Y
Y
Department of Human Life and Culture, Seitoku University, Sagamidai, Matsudo-city, Chiba, Japan. yokon@seitoku.ac.jp
Ohsawa
S
S
Ikegami
S
S
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D006581:Hexachlorobenzene / Q000097:blood / Q000493:pharmacokinetics*; D007774:Lactation; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008892:Milk; D009929:Organ Size; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D004041:Dietary Fats; D006581:Hexachlorobenzene