Mesenteric infarction due to combined protein C deficiency and prothrombin 20210 defects.
The prothrombin gene mutation, 20210A, a guanine to adenine substitution at nucleotide position 20210, has recently been described as an additional risk factor for venous thromboembolic disease. We describe the case of a patient with combined heterozygous prothrombin 20210A mutation and type 1 protein C deficiency who presented with massive mesenteric venous infarction of his small bowel and survived following the use of protein C concentrate and extensive small bowel resection.
Mainwaring
C J
CJ
Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.
Makris
M
M
Thomas
W E
WE
Hampton
K K
KK
Preston
F E
FE
D000925:Anticoagulants / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D008642:Mesenteric Veins; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020151:Protein C Deficiency / Q000150:complications*; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin; D011516:Prothrombin