title: Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
abstract: In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Schuler
authors.forename: M
authors.initials: M
authors.lastname: Zupancic
authors.forename: S
authors.initials: S
authors.lastname: Wietgrefe
authors.forename: K A
authors.initials: KA
authors.lastname: Staskus
authors.forename: K A
authors.initials: KA
authors.lastname: Reimann
authors.forename: T A
authors.initials: TA
authors.lastname: Reinhart
authors.forename: M
authors.initials: M
authors.lastname: Rogan
authors.forename: W
authors.initials: W
authors.lastname: Cavert
authors.forename: C J
authors.initials: CJ
authors.lastname: Miller
authors.forename: R S
authors.initials: RS
authors.lastname: Veazey
authors.forename: D
authors.initials: D
authors.lastname: Notermans
authors.forename: S
authors.initials: S
authors.lastname: Little
authors.forename: S A
authors.initials: SA
authors.lastname: Danner
authors.forename: D D
authors.initials: DD
authors.lastname: Richman
authors.forename: D
authors.initials: D
authors.lastname: Havlir
authors.forename: J
authors.initials: J
authors.lastname: Wong
authors.forename: H L
authors.initials: HL
authors.lastname: Jordan
authors.forename: T W
authors.initials: TW
authors.lastname: Schacker
authors.forename: P
authors.initials: P
authors.lastname: Racz
authors.forename: K
authors.initials: K
authors.lastname: Tenner-Racz
authors.forename: N L
authors.initials: NL
authors.lastname: Letvin
authors.forename: S
authors.initials: S
authors.lastname: Wolinsky
authors.forename: A T
authors.initials: AT
authors.lastname: Haase
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology*; D002453:Cell Cycle; D002584:Cervix Uteri / Q000821:virology; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D008198:Lymph Nodes / Q000821:virology; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D012367:RNA, Viral / Q000032:analysis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D013997:Time Factors; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral