[Cancer metastasis and extracellular matrix].
We investigated the roles of the extracellular matrix, especially of hyaluronan, in cancer metastasis. A positive relationship was shown between hyaluronan synthetic activity and the metastatic ability of cancer cells by manipulating regulation of gene expression of hyaluronan synthases. These techniques may provide future therapeutic methods for cancer metastasis.
Itano
N
N
Institute for Molecular Science of Medicine, Aichi Medical University, Japan.
Yamada
Y
Y
Yoshida
M
M
Kimata
K
K
D000818:Animals; D002455:Cell Division; D003001:Cloning, Molecular; D005109:Extracellular Matrix / Q000378:metabolism* / Q000502:physiology; D014453:Glucuronosyltransferase / Q000235:genetics; D016695:Glycosyltransferases; D006801:Humans; D000076002:Hyaluronan Synthases; D006820:Hyaluronic Acid / Q000032:analysis / Q000096:biosynthesis*; D008565:Membrane Proteins; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology*; D014166:Transferases; D029867:Xenopus Proteins
D008565:Membrane Proteins; D029867:Xenopus Proteins; D006820:Hyaluronic Acid; D014166:Transferases; D016695:Glycosyltransferases; D014453:Glucuronosyltransferase; C056944:HAS1 protein, Xenopus; D000076002:Hyaluronan Synthases