title: Acetophenone glycosides from thyme (Thymus vulgaris L.).
abstract: Four acetophenone glycosides were isolated from the butanol-soluble fraction of thyme extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR). Among them, two new compounds, 4-hydroxyacetophenone 4-O-[5-O-(3, 5-dimethoxy-4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D -gl ucopyranoside (1) and 4-hydroxyacetophenone 4-O-[5-O-(4-hydroxybenzoyl)-beta-D-apiofuranosyl]-(1-->2)-beta-D-+ ++gluc opyranoside (2), were determined. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human leukemia cells.
authors.affiliation: Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901-8520, USA.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Kikuzaki
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: A
authors.initials: A
authors.lastname: Kahyaoglu
authors.forename: M T
authors.initials: MT
authors.lastname: Huang
authors.forename: N
authors.initials: N
authors.lastname: Nakatani
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D018922:HL-60 Cells; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000098:Acetophenones; D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D006027:Glycosides