title: Duration of apnoea with two different intubating doses of remifentanil.
abstract: We have studied the apnoea time after induction with two successful drug intubating regimes, both containing remifentanil. Group 1 (n = 20); propofol 2 mg kg-1 and remifentanil 2 micrograms kg-1 and group 2 (n = 20); propofol 2 mg kg-1, remifentanil 1 microgram kg-1 and lignocaine 1 mg kg-1. Intubation was possible in all 40 patients, and regarded as acceptable in 90% and 85% of patients, respectively. The median time to the return of spontaneous respiration was 487 s in group 1 and 270 s in group 2 (P < 0.05). Median end-tidal CO2 concentration at the time of the first spontaneous respiration was 7.37 kPa in group 1 and 6.3 kPa in group 2 (P < 0.05). Both groups had a decrease in heart rate after induction, but this failed to reach either clinical or statistical significance, and no patient required atropine. Similarly, there was a decrease in arterial pressure after induction in both groups (P < 0.05), but this was not deemed to be clinically significant. Only two patients in each group required ephedrine 6 mg before arterial pressure was restored to within 25% of the base-line. Intubating conditions were similar in both groups, but group 2 provided a significantly shorter apnoea time.
authors.affiliation: Department of Anaesthesia, Victoria Infirmary, Glasgow, UK.
authors.forename: A
authors.initials: A
authors.lastname: Woods
authors.forename: S
authors.initials: S
authors.lastname: Grant
authors.forename: A
authors.initials: A
authors.lastname: Davidson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D000779:Anesthetics, Local; D001049:Apnea / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage; D011446:Prospective Studies; D000077208:Remifentanil; D013997:Time Factors
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D010880:Piperidines; D002245:Carbon Dioxide; D008012:Lidocaine; D000077208:Remifentanil