The effect of perinatal hormonal imprinting with 13-cis-retinoic acid (isotretinoin) on the thymic glucocorticoid receptors of female and testosterone level of male adult rats.
In earlier experiments, the long-term effect of perinatal treatment (hormonal imprinting) with all-trans-retinol and all-trans-retinoic acid on the thymic glucocorticoid and uterine estrogen receptors was studied and was found effective. In the present experiments, the imprinting effect of four retinoids (13-cis-retinaldehyde, 13-cis-retinoic acid, 9-cis-retinaldehyde and 9-cis-retinoic acid) was investigated, using receptor kinetic analysis and sexual hormone (testosterone and progesterone) level determinations. Exclusively 13-cis-retinoic acid (isotretinoin) had an effect, significantly decreasing glucocorticoid receptor affinity and increasing serum testosterone level. Relationships with RAR-RXR receptor binding and teratogenicity is discussed.
Csaba
G
G
Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.
Gaál
A
A
Inczefi-Gonda
A
A
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D018392:Genomic Imprinting; D015474:Isotretinoin / Q000494:pharmacology*; D008297:Male; D011374:Progesterone / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D013739:Testosterone / Q000097:blood*; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism
D011965:Receptors, Glucocorticoid; D013739:Testosterone; D011374:Progesterone; D015474:Isotretinoin