Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study.
Endometrial natural killer (NK) cells were compared in luteal-phase endometrial samples from women with recurrent miscarriage and from normal subjects. Cryostat sections were labelled using a monoclonal antibody to CD56 using an avidin-biotin complex method and a morphometric study performed. Increased mean numbers of CD56+ cells were documented in the endometrium of women with recurrent early miscarriage only. These findings suggest a possible role for NK cells in the pathogenesis of recurrent early pregnancy loss.
Clifford
K
K
Departments of Obstetrics and Gynaecology and Histopathology, Imperial College School of Medicine at St Mary's, London W2 1NY, UK.
Flanagan
A M
AM
Regan
L
L
D000026:Abortion, Habitual / Q000473:pathology*; D000328:Adult; D000911:Antibodies, Monoclonal; D019002:CD56 Antigen / Q000032:analysis*; D004717:Endometrium / Q000276:immunology / Q000473:pathology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology* / Q000502:physiology; D018655:Lymphocyte Count; D011247:Pregnancy
D000911:Antibodies, Monoclonal; D019002:CD56 Antigen