Revised organ partition of thorium-232 in thorotrast patients.
Risk estimates for internally deposited alpha particles in humans, such as those for alpha-particle-induced leukemia, have been derived from data on the toxicity of (232)Th in patients injected with Thorotrast. Their derivation requires both epidemiological data and organ doses calculated from the volume of Thorotrast injected and a knowledge of its pattern of deposition within the body. However, accumulating evidence suggests that the organ partition of (232)Th that has commonly been used for dosimetry (i.e. liver:spleen:red bone marrow: others tissues = 59:29:9:3) is inaccurate. In the present study, the organ distribution of (232)Th has been recalculated using a revised averaging method and both published data and our own unpublished data. For the three major organs of deposition (liver, spleen and bone marrow), activity concentration data were selected from 27 published papers and data sets including 140 newly compiled Japanese cases. For organs of minor storage, both published data for 38 German and 24 Japanese autopsy cases and new data were used. The revised estimate of the relative partition of (232)Th among the above organs was 53:14:25:8. It follows that doses calculated to date are essentially correct for the liver but are too high for the spleen and about three times too low for the red bone marrow. This suggests that the risk of alpha-particle-induced leukemia, per unit of alpha-particle dose, in Thorotrast patients is about three times lower than previously thought.
Ishikawa
Y
Y
Department of Pathology, The Cancer Institute, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.
Humphreys
J A
JA
Collier
C G
CG
Priest
N D
ND
Kato
Y
Y
Mori
T
T
Machinami
R
R
D001853:Bone Marrow / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013910:Thorium / Q000493:pharmacokinetics*; D013911:Thorium Dioxide / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D013910:Thorium; D013911:Thorium Dioxide