Immune considerations in tissue engineering.
This article discusses the interplay between manmade living tissues and nature's given ones. Through a multidisciplinary approach, new strategies are outlined to control early inflammatory biochemical events, cell migration and development, and matrix deposition, all of them directed toward the acellular component of tissue-engineered constructs. The construct's resident nonautologous cells are targeted by cell- and humoral-mediated reactions, and modulatory strategies are applied to arrest rejection. The fate of ex vivo virally transfected, genetically engineered cells also is reviewed.
Llull
R
R
Division of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA.
D001672:Biocompatible Materials; D001709:Biotechnology; D018929:Cell Culture Techniques; D017690:Cell Transplantation; D005818:Genetic Engineering; D005822:Genetic Vectors; D006801:Humans; D007165:Immunosuppression Therapy; D014181:Transplantation Immunology; D014780:Viruses / Q000276:immunology
D001672:Biocompatible Materials