Gaze direction modulates finger movement activation patterns in human cerebral cortex.
We investigated whether gaze direction modified the pattern of finger movement activation in human cerebral cortex using functional magnetic resonance imaging (MRI). Participants performed a sequential finger-tapping task or made no finger movements while maintaining gaze in the direction of the moving hand (aligned conditions) or away from the location of the moving hand. Functional MR signals, measured in the hemisphere contralateral to the moving hand, revealed finger movement-related activation in primary motor cortex, lateral and medial premotor cortex, and a wide extent of the lateral superior and inferior parietal lobules. In each area, the extent of the finger movement activation increased when static gaze was more aligned with the moving hand compared to when gaze was directed away from the moving hand. These data suggest the existence of large-scale cortical networks related to finger actions and indicate that skeletomotor processing in the cerebral cortex is consistently modified by gaze direction signals.
Baker
J T
JT
Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA.
Donoghue
J P
JP
Sanes
J N
JN
D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D005385:Fingers; D005403:Fixation, Ocular / Q000502:physiology*; D007839:Functional Laterality; D006225:Hand; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology; D009415:Nerve Net / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology