Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.
We examined the relationship between the histochemical distribution of endogenous GLP-1 (7-36) amide in the hippocampus and memory impairment assessed by a step-through type passive avoidance task in rats continuously infused with beta-amyloid protein (1-40) into the lateral cerebroventricle using a mini-osmotic pump. Our results demonstrated that endogenous GLP-1 (7-36) amide appears in the hippocampus accompanied by progression of memory impairment. Electrophysiological studies also indicated that endogenous GLP-1 inhibits hippocampal neuronal activity in beta-amyloid protein-treated rats.
Oka
J
J
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Suzuki
E
E
Goto
N
N
Kameyama
T
T
D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology; D005934:Glucagon / Q000502:physiology*; D052216:Glucagon-Like Peptide 1; D000067757:Glucagon-Like Peptide-1 Receptor; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D020547:Lateral Ventricles; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology*; D011498:Protein Precursors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D018027:Receptors, Glucagon / Q000378:metabolism
D016229:Amyloid beta-Peptides; C000593835:Glp1r protein, rat; D000067757:Glucagon-Like Peptide-1 Receptor; D010446:Peptide Fragments; D011498:Protein Precursors; D018027:Receptors, Glucagon; C083773:exendin (9-39); D052216:Glucagon-Like Peptide 1; D005934:Glucagon