Anti-carcinogenic activity of the roots of Panax notoginseng. II.
The extract of the roots of Panax notoginseng (Araliaceae) exhibited a significant anti-tumor-promoting activity on two-stage carcinogenesis of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and a mycotoxin, fumonisin B1, as a non-12-O-tetradecanoylphorbol-13-acetate (non-TPA) type promoter. Further, the extract exhibited the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexen amide (NOR-1) as an initiator and TPA as a promoter.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan.
Takasaki
M
M
Tokuda
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene