Role of ventilatory drive in asthma and chronic obstructive pulmonary disease.
The ventilatory drive is affected by several factors such as chemosensitivity, basal arterial oxygen or carbon dioxide tension, mechanical impedance, and respiratory muscle dysfunction. Blunted ventilatory drive or a decrease in the perception of dyspnea in bronchial asthma and chronic obstructive pulmonary disease (COPD) could lead to a decrease in the alarm reaction to dangerous situations such as severe airway obstruction, severe hypoxemia, or severe hypercapnia. This could delay management and treatment, causing an increase in the morbidity and mortality of patients with bronchial asthma and COPD. The ventilatory drive to chemical stimuli can be altered by a beta-2-agonist, oxygen administration; and lung volume reduction, and an increased dyspnea sensation may be improved by corticosteroid, chest wall vibration, or lung volume reduction. The ventilatory drive has been found to play a key role in determining the severity of asthma and COPD.
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First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000402:Airway Obstruction / Q000503:physiopathology; D001249:Asthma / Q000503:physiopathology* / Q000628:therapy; D002245:Carbon Dioxide / Q000097:blood; D002628:Chemoreceptor Cells / Q000502:physiology; D004417:Dyspnea / Q000503:physiopathology; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000503:physiopathology* / Q000628:therapy; D010100:Oxygen / Q000097:blood; D010102:Oxygen Inhalation Therapy; D011013:Pneumonectomy; D012119:Respiration; D015656:Respiratory Mechanics / Q000502:physiology; D012132:Respiratory Muscles / Q000503:physiopathology; D012677:Sensation / Q000502:physiology; D015996:Survival Rate
D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D002245:Carbon Dioxide; D010100:Oxygen