title: Insecticidal, anti-juvenile hormone, and fungicidal activities of organic extracts from different Penicillium species and their isolated active components.
abstract: Organic extracts from mycelium and culture broth of 21 Penicillium isolates have been tested for insecticidal, insect anti-juvenile hormone (anti-JH), and antifungal activities. Culture broth extracts were the most active, mainly against insects; nearly 25% of them have shown high entomotoxicity (100% mortality at 100 microg/cm(2)). A strong in vivo anti-JH activity against Oncopeltus fasciatus Dallas was detected in the culture broth extracts from P. brevicompactum P79 and P88 isolates. The two new natural products isolated from P79, N-(2-methyl-3-oxodec-8-enoyl)-2-pyrroline (1) and 2-hept-5-enyl-3-methyl-4-oxo-6,7,8,8a-tetrahydro-4H-pyrrolo[2,1-b]-1, 3-oxazine (2), possessed anti-JH and insecticidal activity, respectively, against O. fasciatus. Synthesized natural compound 1 has shown an ED(50) of 0.7 microg/nymph when assayed on newly molted fourth-instar nymphs of O. fasciatus. Promising biological activities have also been detected in the synthetic precursors.
authors.affiliation: Departamento de Biotecnología and Instituto de Tecnología Química UPV-CSIC, Universidad Politécnica de Valencia, Valencia, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Castillo
authors.forename: P
authors.initials: P
authors.lastname: Moya
authors.forename: A
authors.initials: A
authors.lastname: Cantín
authors.forename: M A
authors.initials: MA
authors.lastname: Miranda
authors.forename: J
authors.initials: J
authors.lastname: Primo
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: E
authors.initials: E
authors.lastname: Primo-Yúfera
mesh_terms: D000818:Animals; D005658:Fungi / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000302:isolation & purification* / Q000494:pharmacology; D007313:Insecta; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology; D007605:Juvenile Hormones / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000737:chemistry* / Q000254:growth & development; D010944:Plants / Q000382:microbiology
chemical_list: D005659:Fungicides, Industrial; D007306:Insecticides; D007605:Juvenile Hormones