Malignant rhabdoid tumor of the colon: report of a case.
A malignant rhabdoid tumor of the colon is very rare and only three cases have been previously described. A 76-year-old man was admitted to the hospital complaining of epigastralgia. An elastic mass was palpable in the right upper abdomen. A barium enema and endoscopic examination showed a giant gyrate tumor arising from the cecum. Abdominal ultrasonography and a computed tomography scan revealed the tumor to be located in the colon associated with multiple liver metastases and gallbladder stones. A right colectomy and cholecystectomy were thus performed. The tumor was histologically composed of sheets of large round and polygonal nuclei with vesicular chromatin, and abundant acidophilic cytoplasm, often containing hyalin-like inclusion. The cytoplasm was positive for vimentin and neuron-specific enolase, and hyaline globules of the rhabdoid tumor cells stained positive for cytokeratin in some cells. Transmission electron microscopy showed characteristic rhabdoid cells with an aggregation of intermediate filaments. A histologic diagnosis of malignant rhabdoid tumor of the colon was made. The tumor demonstrated several unusual findings for malignant rhabdoid tumors including diploidy by a flow cytometric analysis, and positive nuclear immunohistochemical staining for p53 protein and Ki-67 antigen. We report herein the third known case of a pure colonic rhabdoid tumor.
Nakamura
I
I
Department of Surgery II, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.
Nakano
K
K
Nakayama
K
K
Ishii
Y
Y
Ohta
K
K
Takahashi
M
M
Yamada
T
T
Yamaguchi
K
K
Sakuma
H
H
Tsuchiya
A
A
Takenoshita
S
S
D000368:Aged; D002430:Cecal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002432:Cecum / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D018335:Rhabdoid Tumor / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery
D004273:DNA, Neoplasm