Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats.
1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-induced hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p-sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-induced hypotension via activation of adenosine A1 receptors in the brain of Wistar rats.
Cheng
J T
JT
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC. jtcheng@mail.ncku.edu.tw
Wang
C J
CJ
Hsu
F L
FL
D018663:Adrenergic Agents / Q000633:toxicity*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001565:Benzoates; D001794:Blood Pressure / Q000187:drug effects; D001952:Bridged-Ring Compounds; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology*; D006145:Guanethidine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D039821:Monoterpenes; D010946:Plants, Medicinal; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D014970:Xanthines / Q000494:pharmacology; D006027:Glycosides
D018663:Adrenergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D006145:Guanethidine; D039821:Monoterpenes; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D014970:Xanthines; C015423:peoniflorin; D006027:Glycosides; C051360:1,3-dipropyl-8-cyclopentylxanthine