Sultamo-steroid analogues, Part VII: Synthesis of epi-androsterone derivatives with potential activity.
The reaction of epi-androsterone with cyanoacetyl hydrazine (2) gave the hydrazone derivative 3. The reactivity of 3 towards chemical reagents was studied to give pyridine, thiazole and thiophene derivatives.
Doss
S H
SH
Hormone Department, National Research Centre, Dokki, Cairo, Egypt. rmmohareb@hotmail.com
Louca
N A
NA
Elmegeed
G A
GA
Mohareb
R M
RM
D000738:Androsterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011725:Pyridines; D013844:Thiazoles; D013876:Thiophenes; D000738:Androsterone