title: [Elderly dyserythropoietic anemia first diagnosed after presentation of hemorrhagic gastric ulcer].
abstract: A 71-year-old man presented with epigastralgia and tarry stool. Laboratory examination showed anemia (Hb 7.1 g/dl) due to hemorrhagic gastric ulcer and positive Coombs' test without features of hemolysis. Initial bone marrow smears disclosed normal granulocytes and megakaryocytes, but only erythroid hyperplasia with multinuclearity and megaloblastosis was identified. Cytogenetic studies revealed normal karyotype. Congenital dyserythropoietic anemia (CDA) type II was initially suspected. Serologically, however, acid hemolysis and anti-I * i tests were negative as were the results of another Coombs' test. The second bone marrow aspiration disclosed a marked decrease in multinucleated erythroblasts together with an increase in those that had internuclear chromatin bridges. Electron microscopy of bone marrow specimens demonstrated morphological features of CDA types I and II, thus yielding a final diagnosis of elderly dyserythropoietic anemia, which is similar to both CDA types. It was suggested that the reactive secretion of erythropoietin due to bleeding played a role in these pathologic changes.
authors.affiliation: Department of Internal Medicine, Ono City Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Kadowaki
authors.forename: K
authors.initials: K
authors.lastname: Chihara
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: K
authors.initials: K
authors.lastname: Kanki
authors.forename: K
authors.initials: K
authors.lastname: Fujio
mesh_terms: D000368:Aged; D000742:Anemia, Dyserythropoietic, Congenital / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D001854:Bone Marrow Cells / Q000473:pathology; D004900:Erythroblasts / Q000473:pathology; D004921:Erythropoietin; D006801:Humans; D006965:Hyperplasia; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000150:complications*; D013276:Stomach Ulcer / Q000150:complications*
chemical_list: D004921:Erythropoietin