Dynamic magnetic resonance imaging of head and neck lesions.
Dynamic magnetic resonance imaging (MRI) has been used to improve the detection of tumors, to determine the tumor extension, and to make differential diagnosis. Most malignant lesions of the head and neck show early enhancement and early washout of contrast media on dynamic MRI, but the tumor characterization remains unclear. Pharmacokinetic analysis of dynamic MRI can provide information about the permeability of Gd-DTPA in the tumor that may reflect the oxygen concentration of the tumor and the amount of drug delivered to the tumor. This information may be useful in the prediction of radiation and/or chemotherapy response of the tumor.
Baba
Y
Y
Department of Radiology, Kumamoto University School of Medicine, Kumamoto-city, Japan. isolde@kaiju.medic.kumamoto-u.ac.jp
Yamashita
Y
Y
Onomichi
M
M
Murakami
R
R
Takahashi
M
M
D000465:Algorithms; D003287:Contrast Media / Q000493:pharmacokinetics; D005163:Factor Analysis, Statistical; D005682:Gadolinium / Q000493:pharmacokinetics; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000493:pharmacokinetics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D009942:Organometallic Compounds / Q000493:pharmacokinetics
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D019786:Gadolinium DTPA