title: Active muscle and whole body lactate kinetics after endurance training in men.
abstract: We evaluated the hypotheses that endurance training decreases arterial lactate concentration ([lactate](a)) during continuous exercise by decreasing net lactate release () and appearance rates (R(a)) and increasing metabolic clearance rate (MCR). Measurements were made at two intensities before [45 and 65% peak O(2) consumption (VO(2 peak))] and after training [65% pretraining VO(2 peak), same absolute workload (ABT), and 65% posttraining VO(2 peak), same relative intensity (RLT)]. Nine men (27.4 +/- 2.0 yr) trained for 9 wk on a cycle ergometer, 5 times/wk at 75% VO(2 peak). Compared with the 65% VO(2 peak) pretraining condition (4.75 +/- 0.4 mM), [lactate](a) decreased at ABT (41%) and RLT (21%) (P < 0.05). decreased at ABT but not at RLT. Leg lactate uptake and oxidation were unchanged at ABT but increased at RLT. MCR was unchanged at ABT but increased at RLT. We conclude that 1) active skeletal muscle is not solely responsible for elevated [lactate](a); and 2) training increases leg lactate clearance, decreases whole body and leg lactate production at a given moderate-intensity power output, and increases both whole body and leg lactate clearance at a high relative power output.
authors.affiliation: Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley 94720, USA.
authors.forename: B C
authors.initials: BC
authors.lastname: Bergman
authors.forename: E E
authors.initials: EE
authors.lastname: Wolfel
authors.forename: G E
authors.initials: GE
authors.lastname: Butterfield
authors.forename: G D
authors.initials: GD
authors.lastname: Lopaschuk
authors.forename: G A
authors.initials: GA
authors.lastname: Casazza
authors.forename: M A
authors.initials: MA
authors.lastname: Horning
authors.forename: G A
authors.initials: GA
authors.lastname: Brooks
mesh_terms: D000328:Adult; D000465:Algorithms; D001823:Body Composition / Q000502:physiology; D004032:Diet; D005080:Exercise Test; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007700:Kinetics; D019344:Lactic Acid / Q000378:metabolism*; D007866:Leg / Q000502:physiology; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D010807:Physical Endurance / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D019344:Lactic Acid