Quantitative T*(2) and T'(2) maps during reversible focal cerebral ischemia in rats: separation of blood oxygenation from nonsusceptibility-based contributions.
Quantitative imaging contrast is evaluated which allows the selective measurement of the blood oxygenation state during cerebral ischemia within a multiparametric imaging study on rats. In a first step, the ambiguities arising in T*(2)-weighted images due to T*(2) heterogeneity are eliminated by calculating T*(2) maps. Then, 1/T'(2) maps are calculated according to 1/T'(2) = 1/T*(2) - 1/T(2) to eliminate nonsusceptibility-induced changes of 1/T*(2) after the induction of stroke. This is of particular importance in the presence of vasogenic edema. The changes Delta(1/T'(2)) after the onset of ischemia selectively quantify the variations of the deoxyhemoglobin content during the development of the infarct. The presented results are not available from conventionally recorded parameters of a stroke study and, together with perfusion-weighted images, form a powerful combination to analyze the oxygen consumption and the metabolism of the tissue. Magn Reson Med 42:1027-1032, 1999.
Grüne
M
M
Max-Planck-Institute for Neurological Research, Cologne, Germany.
van Dorsten
F A
FA
Schwindt
W
W
Oláh
L
L
Hoehn
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D051381:Rats; D017207:Rats, Sprague-Dawley
D010100:Oxygen