title: The effect of insulin therapy on osseointegration in a diabetic rat model.
abstract: As patients become edentulous, dental implants have been one treatment alternative. Although studies indicate that dental implants inserted in healthy patients have been successful, their placement in the diabetic patient remains controversial. The purpose of this study utilizing histometric parameters compares the course of osseous healing around endosseous implants in normal non-diabetic and insulin controlled diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Blood glucose was monitored by the glucose-oxidase method and controlled with daily insulin injections. Sterile custom fabricated commercially pure solid cylinder titanium implants, with a titanium plasma-sprayed surface were placed in the femora of each animal. The results indicate that insulin therapy was able to upregulate the formation of bone around implants inserted in the streptozotocin-induced diabetic rat model. However, histometric parameters utilized indicated that although the total quantity of bone formation was greater in the insulin controlled group, there was significantly less bone-to-implant contact in the insulin controlled diabetic group as compared to normal non-diabetic controls.
authors.affiliation: Harvard School of Dental Medicine, Department of Periodontology, Boston, Massachusetts 02115, USA. jfiorell@warren.med.harvard.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Fiorellini
authors.forename: M L
authors.initials: ML
authors.lastname: Nevins
authors.forename: A
authors.initials: A
authors.lastname: Norkin
authors.forename: H P
authors.initials: HP
authors.lastname: Weber
authors.forename: N Y
authors.initials: NY
authors.lastname: Karimbux
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D003758:Dental Implantation, Endosseous; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D005269:Femur; D020007:Implants, Experimental; D007328:Insulin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin
chemical_list: D007328:Insulin; D013311:Streptozocin