Metallic wires with an adherent lubricious and blood-compatible polymeric coating and their use in the manufacture of novel slippery-when-wet guidewires: possible applications related to controlled local drug delivery.
A new procedure was developed for the controlled application of adherent hydrophilic and biocompatible coatings onto the surface of "endless" metallic wires. Use of copolymers of 1-vinyl-2-pyrrolidinone and alkylmethacrylates provided coatings with excellent adherence and lubricity, and markedly low thrombogenicity. Coated wires could be spiralized without damaging the coating; the resulting coils are potentially useful as lubricious guidewires for use in, for example, interventional cardiology or urology. This study demonstrates that the lubricity of the coating is dependent on the composition (hydrophilicity) of the coating biomaterial, as well as on the thickness of the coating. Furthermore, the results imply that the adherence of the hydrophilic coating is essentially due to entanglement of the binder polymer chains and the hydrophilic copolymer chains. Moreover, the idea to use the hydrophilic coating on the wire as a temporary depot for controlled local drug delivery was explored. The coating was loaded with the dye rhodamine, and release of the dye upon immersion of the coated wire in water was studied. This work revealed that release of the drug is dependent on the composition of the coating. The potential utility of such wires with a drug-charged coating for controlled local drug delivery is discussed briefly.
Hanssen
H H
HH
MC Tec, P.O. Box 9, 5900 AA Venlo, The Netherlands.
Wetzels
G M
GM
Benzina
A
A
van der Veen
F H
FH
Lindhout
T
T
Koole
L H
LH
D001769:Blood / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000633:toxicity*; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D006801:Humans; D008153:Lubrication; D009682:Magnetic Resonance Spectroscopy; D008670:Metals / Q000097:blood / Q000633:toxicity*; D011108:Polymers / Q000633:toxicity*; D012235:Rhodamines; D013927:Thrombosis / Q000139:chemically induced
D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D005456:Fluorescent Dyes; D008670:Metals; D011108:Polymers; D012235:Rhodamines