[Liver concentration of CPT-11, SN-38 and SN-38 GLU in intraperitoneal and intravenous administration of CPT-11].
Our previous mouse experiment showed intraperitoneal administration of CPT-11 was more effective not only for peritoneal seeding but for liver metastases than intravenous administration of CPT-11. We studied tissue concentrations of the liver when CPT-11 was administered intraperitoneally or intravenously for ICR mice. Mice liver was resected at 15 min, 1, 2, 4, 8 and 26 hours after intraperitoneal or intravenous administration of 40 mg/kg CPT-11. CPT-11, SN-38 and SN-38 GLU were measured with HPLC. The liver concentration of CPT-11 at 15 min after intravenous administration was higher than after intraperitoneal administration. A higher liver CPT-11 concentration was prolonged in the intraperitoneal administration group. No differences were demonstrated in the concentrations of SN-38 and SN-38 GLU between i.p. and i.v. groups.
Maruyama
M
M
Dept. of Surgery, Tokyo Metropolitan Ohkubo Hospital.
Nagahama
T
T
Yuasa
Y
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000032:analysis* / Q000493:pharmacokinetics; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D005260:Female; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D000077146:Irinotecan; D008099:Liver / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR
D000972:Antineoplastic Agents, Phytogenic; C106003:SN38-Glu; D000077146:Irinotecan; D002166:Camptothecin