title: [Selenoproteins--atypical function of the UGA codon].
abstract: Selenium is an essential trace element for animals and humans. It's a structural component of the active center of several important mammalian enzymes, like gluthatione peroxidase (GSH-Px), iodothyronine deiodinase, and others selenoproteins. Paper describes selenium functions in physiological states, and mechanism of incorporation of selenocysteine into selenoproteins. This incorporation requires the alternative decoding of UGA, which typically serves as a stop codon. The most important element is the secondary structure of mRNA named SECIS (selenocysteine inserstion sequence).
authors.affiliation: Laboratorium Wirusologii, Instytutu Immunologii i Terapii Doświadczalnej PAN, Wrocławiu.
authors.forename: K
authors.initials: K
authors.lastname: Rybka
mesh_terms: D000818:Animals; D003062:Codon / Q000378:metabolism*; D004798:Enzymes / Q000737:chemistry; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D011387:Prokaryotic Cells / Q000378:metabolism; D014176:Protein Biosynthesis; D017433:Protein Structure, Secondary; D011506:Proteins; D012333:RNA, Messenger / Q000032:analysis; D012643:Selenium / Q000032:analysis / Q000378:metabolism*; D017279:Selenocysteine / Q000378:metabolism*; D051140:Selenoproteins
chemical_list: D003062:Codon; D004798:Enzymes; D011506:Proteins; D012333:RNA, Messenger; D051140:Selenoproteins; D017279:Selenocysteine; D012643:Selenium