title: Large granular lymphocytic leukemia in a mixed breed dog.
abstract: A mixed breed dog was diagnosed with large granular lymphocytic leukemia. Immunophenotypic analysis indicated the lymphocytes were CD3+, CD8+ T cells expressing the alpha beta T cell receptor and a leukointegrin, alpha d. Chemotherapy and splenectomy resulted in an initial reduction in the lymphocyte count.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
authors.forename: K W
authors.initials: KW
authors.lastname: Lau
authors.forename: S A
authors.initials: SA
authors.lastname: Kruth
authors.forename: C E
authors.initials: CE
authors.lastname: Thorn
authors.forename: W
authors.initials: W
authors.lastname: Vernau
authors.forename: P
authors.initials: P
authors.lastname: Moore
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D005260:Female; D015458:Leukemia, T-Cell / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D013156:Splenectomy / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents