title: [Sydenham's chorea in children].
abstract: BACKGROUND
  Sydenham's chorea was the most common form of acquired chorea in childhood. Its incidence has declined since the use of antibiotics. The aim of our study was to determine the hospital incidence of this disease and to illustrate the clinical characteristics and outcome of this disease in Tunisia.
  
  
  METHODS
  Retrospective study of 15 cases of Sydenham's chorea, seen between 1987 and 1997.
  
  
  RESULTS
  Our patients (five boys and ten girls) represented 5.6 per 1000 hospitalized children. Their mean age was 10.5 years. Two patients had a history of rheumatic fever and five had a history of throat infection during the month before chorea. The onset of symptoms was acute in five cases and insidious in ten. Choreic movements were generalized but asymmetrical in 12 cases, and unilateral in three. Psychological disorders were noted in nine cases and hypotonia in six. Rheumatic carditis was found in three patients. No patient had an obvious increase in sedimentation rate, and antistreptolysin were increased in 50% of cases. All patients were given haloperidol and five steroids, 11 were given antibiotics at the attack of chorea and 13 received secondary prevention with benzathine penicillin. Initially, abnormal movements disappeared in all cases after a mean of three months. Three patients relapsed and two among them still show abnormal movements and psychological disorders after a follow-up of 3 and 3.5 years respectively.
  
  
  CONCLUSIONS
  Sydenham's chorea, although less frequent than previously, is not exceptional in Tunisia. Malignant forms are not observed, but two of 15 patients developed a chronic form with sequelae. No correlation is found between outcome and secondary prevention of streptococcal infections.
authors.affiliation: Service de pédiatrie, urgences et consultations externes, hôpital d'enfants de Tunis.
authors.forename: N
authors.initials: N
authors.lastname: Ghram
authors.forename: C
authors.initials: C
authors.lastname: Allani
authors.forename: B
authors.initials: B
authors.lastname: Oudali
authors.forename: Z
authors.initials: Z
authors.lastname: Fitouri
authors.forename: S
authors.initials: S
authors.lastname: Ben Becher
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D002648:Child; D002819:Chorea / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male; D012189:Retrospective Studies; D012213:Rheumatic Fever / Q000150:complications / Q000188:drug therapy; D012737:Sex Factors; D014416:Tunisia / Q000453:epidemiology
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D018726:Anti-Dyskinesia Agents; D006220:Haloperidol