[Biological action mechanisms and effects of calcitriol].
Vitamin D is an important regulator of calcium homeostasis in the body and it plays an essential role in bone metabolism. 1,25(OH)2D (calcitriol), the active metabolite of vitamin D stimulates intestinal calcium and phosphate absorption, thereby maintaining sufficient concentrations of these ions in the extracellular fluids, necessary for normal mineralization of bone matrix. Furthermore, calcitriol exerts a number of important functions in regulating bone metabolism. Similar to other classical steroid hormones, calcitriol regulates the transcription of a large number of target genes. A large number of recent studies of the mechanisms of genomic actions of calcitriol have been published. The aim of this review is to give a summary of these recent findings. The interaction between calcitriol and the vitamin D receptor as well as receptor structure and function in relation to transcriptional regulation are discussed.
Kveiborg
M
M
Medicinsk endocrinologisk afdeling C, og, Arhus Universitetshospital, Arhus Amtssygehus.
Mosekilde
L
L
Eriksen
E F
EF
Kassem
M S
MS
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism; D002117:Calcitriol / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D014807:Vitamin D / Q000235:genetics / Q000378:metabolism
D018167:Receptors, Calcitriol; D014807:Vitamin D; D002117:Calcitriol; D002118:Calcium