Genetically manipulated animals and their use in experimental research.
Genetically manipulated animals generated by transgenic and gene-targeting (knockout) technology have contributed tremendously to our understanding of gene function and regulation at the molecular level in the context of the whole organism. They are also becoming powerful tools for human disease studies and therapeutic drug development. An overview of the current development of these animals and their application in biological and medical researches is provided in this article.
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Department of Biological Sciences, Faculty of Science, National University of Singapore. dbsgerw@nus.edu.sg
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D019149:Bioreactors; D004195:Disease Models, Animal; D018390:Gene Targeting; D015316:Genetic Therapy; D006801:Humans; D012106:Research; D014183:Transplantation, Heterologous