title: Epithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder.
abstract: Sarcoma represents less than 2% of all neoplasms diagnosed or recognized in effusions. Epithelioid peripheral nerve sheath tumor is a rare tumor that is difficult to differentiate from other epithelioid tumors without the use of ancillary studies. A 39-year-old paraplegic man presented with hematuria and a bladder mass that extended to involve the pelvic peritoneum. Light microscopy using hematoxylin-eosin, Papanicolaou, and immunohistochemical stains as well as transmission electron microscopy showed features of epithelioid malignant peripheral nerve sheath tumor with rhabdoid features and an accompanying eosinophilic infiltrate. Cytologic smears confirmed the similarities between the primary tumor in the bladder and the cells in the pelvic fluid and excluded the possibility of reactive changes related to postsurgical radiation. Ancillary studies were critical in narrowing the differential diagnoses and reaching the final conclusion.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Eltoum
authors.forename: R J
authors.initials: RJ
authors.lastname: Moore
authors.forename: W
authors.initials: W
authors.lastname: Cook
authors.forename: D R
authors.initials: DR
authors.lastname: Crowe
authors.forename: W H
authors.initials: WH
authors.lastname: Rodgers
authors.forename: G P
authors.initials: GP
authors.lastname: Siegal
mesh_terms: D000038:Abscess / Q000175:diagnosis; D000328:Adult; D001202:Ascitic Fluid / Q000166:cytology; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D006406:Hematoma / Q000175:diagnosis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009442:Neurilemmoma / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D017933:Peripheral Nervous System / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor