Trophoblastic pulmonary embolization after hysterectomy for invasive complete mole. A case report.
BACKGROUND
Trophoblastic pulmonary embolization usually occurs after evacuation of a molar pregnancy when the uterus is larger than dates and the human chorionic gonadotropin level is > 100,000 mIU/mL. It has a dramatic onset, with dyspnea, tachypnea, bilateral pulmonary infiltrates and low Po2 levels. Treatment requires supportive measures only. Intubation is rarely required. The clinical course is short-lived, with gradual improvement after 48 hours and complete resolution in 72 hours. There are no long-term sequelae. Differential diagnosis includes pulmonary embolization, fluid overload and aspiration.


METHODS
A 27-year-old, Caucasian woman, gravida 4, para 2, spontaneous abortion 1, developed presumed trophoblastic pulmonary embolization following abdominal hysterectomy for an invasive mole. The clinical course was typical of this condition, with spontaneous clearing in 72 hours with supportive measures only.


CONCLUSIONS
Trophoblastic pulmonary embolization can occur following abdominal hysterectomy for invasive mole as well as after molar evacuation and should be considered part of the differential diagnosis if patients present postoperatively with acute respiratory distress.
Garner
E I
EI
New England Trophoblastic Disease Center, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, MA 02115, USA.
Chang-Lee
W Y
WY
Lu
K H
KH
Goldstein
D P
DP
Berkowitz
R S
RS
D000328:Adult; D004619:Embolism, Amniotic Fluid / Q000175:diagnosis; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000601:surgery*; D007044:Hysterectomy / Q000009:adverse effects*; D011247:Pregnancy; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome; D014327:Trophoblasts; D014594:Uterine Neoplasms / Q000601:surgery*