title: Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism.
abstract: Cationic ammonium fullerene derivatives (C60-bis(N, N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
authors.affiliation: Kyoritsu College of Pharmacy, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mashino
authors.forename: K
authors.initials: K
authors.lastname: Okuda
authors.forename: T
authors.initials: T
authors.lastname: Hirota
authors.forename: M
authors.initials: M
authors.lastname: Hirobe
authors.forename: T
authors.initials: T
authors.lastname: Nagano
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002244:Carbon; D010100:Oxygen