[Distribution of lymphocytes to tumor tissue and regional lymph nodes in patients with gastric cancer--the effects of oral administration of OK-432].
We attempted to clarify the accumulation of radiolabeled lymphocytes to tumors and regional lymph nodes in patients with gastric carcinoma. The effects of oral administration of OK-432 were also studied. Five patients with gastric cancer and one who underwent endoscopic mucosal resection, were entered in the study. Prior to the tracer study in 3 patients with gastric cancer, 5 KE of OK-432 was administered for 2 days. Peripheral mononuclear cells were separated and labeled with [111] In-tropolone. After the resection of stomach, tumor tissue, normal gastric mucosa, regional lymph nodes, and non-regional lymph nodes were dissected and radioactivity was measured by a gamma-counter. Accumulation of lymphocytes to the tumor tissue and n1 lymph node station was more than two times that in the normal gastric mucosa and ten times that in non-regional lymph nodes. Accumulation of lymphocytes to the n2 station was strongly enhanced by oral administration of OK-432.
Yoshikawa
T
T
Third Dept. of Surgery, Kanagawa Cancer Center.
Saito
M
M
Tsuburaya
A
A
Kobayashi
O
O
Sairenji
M
M
Motohashi
H
H
Yanoma
S
S
Ono
Y
Y
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes; D010844:Picibanil / Q000008:administration & dosage*; D011877:Radionuclide Imaging; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D010844:Picibanil