The 1998 Castroviejo Lecture. New strategies in the treatment of dry-eye states.
OBJECTIVE
To review developments in dry-eye research leading to new therapeutic possibilities and to suggest a prioritizing schema.


METHODS
New development in our understanding of the pathogenesis, diagnoses, and treatment of dry-eye states have been reviewed along with the possible impact on new therapeutic approaches.


RESULTS
A variety of approaches to the pathogenesis and degrees of dry-eye states have emerged, giving rise to significant new approaches to the treatment of these disorders.


CONCLUSIONS
There are now new treatment possibilities. Ranking their development based on their fundamental reversal of disease mechanisms seems a reasonable approach with early therapeutic pay-off.
Lemp
M A
MA
Department of Ophthalmology, Georgetown University, Washington, DC, USA. 74604.576@compuserve.com
D015352:Dry Eye Syndromes / Q000628:therapy*; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D012106:Research
D006728:Hormones; D009883:Ophthalmic Solutions