Homologues of isomeric dideoxynucleosides as potential antiviral agents: synthesis of isodideoxynucleosides with a furanethanol sugar moiety.
The synthesis of a homologues series of compounds related to (R, S)-isodideoxynucleosides has been completed by coupling a variety of natural purine and pyrimidine bases with a modified sugar intermediate. This sugar precursor was prepared regiospecifically and stereospecifically from D-glucose.
Zheng
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Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Nair
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D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D002236:Carbohydrate Conformation; D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D009904:Optical Rotation; D013056:Spectrophotometry, Ultraviolet
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D005663:Furans