title: Genetic relatedness among nontypeable pneumococci implicated in sporadic cases of conjunctivitis.
abstract: Nontypeable Streptococcus pneumoniae is a common cause of epidemic conjunctivitis. A previous molecular fingerprinting study identified a clone of nontypeable pneumococcus that was responsible for a recent outbreak of conjunctivitis. In the present study, we examined the extent to which pneumococci that cause sporadic cases of conjunctivitis are related to this epidemic strain. Using arbitrarily primed BOX-PCR, we have determined that, of 10 nontypeable pneumococci causing sporadic conjunctivitis, 5 were clonal and closely related to a previous outbreak strain, whereas 5 others were genetically diverse.
authors.affiliation: Department of Medicine, Baylor College of Medicine, Houston, Texas.
authors.forename: J H
authors.initials: JH
authors.lastname: Barker
authors.forename: D M
authors.initials: DM
authors.lastname: Musher
authors.forename: R
authors.initials: R
authors.lastname: Silberman
authors.forename: H M
authors.initials: HM
authors.lastname: Phan
authors.forename: D A
authors.initials: DA
authors.lastname: Watson
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D003234:Conjunctivitis, Bacterial / Q000382:microbiology*; D016172:DNA Fingerprinting; D005123:Eye / Q000382:microbiology; D006801:Humans; D007223:Infant; D010802:Phylogeny; D011008:Pneumococcal Infections / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics*