title: [Skin reactions to interferon alpha in a series of 92 patients with multiple sclerosis].
abstract: BACKGROUND
  A significant proportion of multiple sclerosis patients develop cutaneous reactions by interferon beta 1b (IFN-beta). The am of this study was to describe clinically and histologically the cutaneous reactions by IFN-beta.
  
  
  METHODS
  A series of 92 patients with multiple sclerosis in treatment with IFN-beta was followed. Cutaneous biopsy was performed in cases with persistent lesions.
  
  
  RESULTS
  9 out of 92 patients presented eritematous plaques, 4 cutaneous ulcers and 1 sclerodermiform plaques. Vascular thrombosis was demonstrated in 2 cases.
  
  
  CONCLUSIONS
  In patients with multiple sclerosis treated with IFN-beta the persistent skin lesions are more frequent in female patients. Generally is not necessary to stop the treatment.
authors.affiliation: Servicio de Dermatología, Ciutat Sanitària i Universitària de Bellvitge, Barcelona.
authors.forename: Y
authors.initials: Y
authors.lastname: Fortuño
authors.forename: J
authors.initials: J
authors.lastname: Marcoval
authors.forename: I
authors.initials: I
authors.lastname: Gallego
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: T
authors.initials: T
authors.lastname: Arbizu
authors.forename: J
authors.initials: J
authors.lastname: Peyrí
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012737:Sex Factors; D012871:Skin Diseases / Q000139:chemically induced*; D014456:Ulcer / Q000139:chemically induced*
chemical_list: D016899:Interferon-beta