Tea catechin supplementation increases antioxidant capacity and prevents phospholipid hydroperoxidation in plasma of humans.
The effect of green tea catechin supplementation on antioxidant capacity of human plasma was investigated. Eighteen healthy male volunteers who orally ingested green tea extract (254 mg of total catechins/subject) showed 267 pmol of epigallocatechin-3-gallate (EGCg) per milliliter of plasma at 60 min after administration. The plasma phosphatidylcholine hydroperoxide (PCOOH) levels attenuated from 73.7 pmol/mL in the control to 44.6 pmol/mL in catechin-treated subjects, being correlated inversely with the increase in plasma EGCg level. The results suggested that drinking green tea contributes to prevent cardiovascular disease by increasing plasma antioxidant capacity in humans.
Nakagawa
K
K
Laboratory of Biodynamic Chemistry, Tohoku University Graduate School of Life Science and Agriculture, Sendai 981-8555, Japan.
Ninomiya
M
M
Okubo
T
T
Aoi
N
N
Juneja
L R
LR
Kim
M
M
Yamanaka
K
K
Miyazawa
T
T
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D002392:Catechin / Q000097:blood / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D010713:Phosphatidylcholines / Q000097:blood*; D010936:Plant Extracts / Q000494:pharmacology; D012016:Reference Values; D013662:Tea; D013997:Time Factors
D000975:Antioxidants; D010713:Phosphatidylcholines; D010936:Plant Extracts; D013662:Tea; C057590:phosphatidylcholine hydroperoxide; D002392:Catechin