title: Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research.
abstract: Some of the recent publications on the pharmacological, therapeutic and toxicological properties of the antimicrobial agent furazolidone (FZ) are briefly reviewed. In animals, most of the recently published papers focus on (1) the methodology of measuring the residues of the drug and its metabolites in edible tissues; (2) the carcinogenicity and genotoxicity of FZ; (3) the cellular and molecular basis of FZ-induced cardiomyopthy, and the action of different cardioprotectant drugs thereon; and (4) hormonal effects. In humans, the use of FZ as an anti-ulcer drug and in controlling infectious diseases, especially opportunistic infections in AIDS patients, is described.
authors.affiliation: Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Buraydah, Al-Gaseem, Saudi Arabia.
authors.forename: B H
authors.initials: BH
authors.lastname: Ali
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals; D005664:Furazolidone / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D005609:Free Radicals; D008996:Monoamine Oxidase Inhibitors; D005664:Furazolidone