title: High-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in surfactant-treated rabbits with lung injury.
abstract: The aim of this study was to compare high-frequency oscillatory ventilation (HFOV) with conventional mechanical ventilation (CMV) with and without surfactant in the treatment of surfactant-deficient rabbits. A previously described saline lung lavage model of lung injury in adult rabbits was used. The efficacy of each therapy was assessed by evaluating gas exchange, lung deflation stability and lung histopathology. Arterial oxygenation did not improve in the CMV group without surfactant but increased rapidly to prelavage values in the other three study groups. During deflation stability, arterial oxygenation decreased to postlavage values in the group that received HFOV alone, but not in both surfactant-treated groups (HFOV and CMV). The HFOV group without surfactant showed more cellular infiltration and epithelial damage compared with both surfactant-treated groups. There was no difference in gas exchange, lung deflation stability and lung injury between HFOV and CMV after surfactant therapy. It is concluded that the use of surfactant therapy in combination with high-frequency oscillatory ventilation is not superior to conventional mechanical ventilation in improving gas exchange, lung deflation stability and in the prevention of lung injury, if lungs are kept expanded. This indicates that achieving and maintaining alveolar expansion (i.e. open lung) is of more importance than the type of ventilator.
authors.affiliation: Dept. of Anaesthesiology, Erasmus University Rotterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Gommers
authors.forename: A
authors.initials: A
authors.lastname: Hartog
authors.forename: R
authors.initials: R
authors.lastname: Schnabel
authors.forename: A
authors.initials: A
authors.lastname: De Jaegere
authors.forename: B
authors.initials: B
authors.lastname: Lachmann
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D006612:High-Frequency Ventilation / Q000379:methods*; D008055:Lipids / Q000008:administration & dosage / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D010743:Phospholipids; D011175:Positive-Pressure Respiration / Q000379:methods*; D011650:Pulmonary Alveoli / Q000648:ultrastructure; D011659:Pulmonary Gas Exchange; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D011897:Random Allocation; D012131:Respiratory Insufficiency / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D008055:Lipids; D010743:Phospholipids; D011663:Pulmonary Surfactants; C078272:SF-RI 1, bovine surfactant preparation