Ret proto-oncogene rearrangement in thyroid cancer around Semipalatinsk nuclear testing site.
About 50 years ago, on August 29, 1949, the first nuclear device was exploded at the Semipalatinsk nuclear testing site located in the northern part of the Republic of Kazakhstan in the former USSR. Here we describe the first evidence of ret proto-oncogene rearrangement of thyroid cancer tissues around the site.
Alipov
G
G
Ito
M
M
Prouglo
Y
Y
Takamura
N
N
Yamashita
S
S
D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007623:Kazakhstan; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D056918:Nuclear Receptor Coactivators; D009689:Nuclear Warfare; D015513:Oncogene Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011505:Protein-Tyrosine Kinases; D000090063:Proto-Oncogene Mas; D013964:Thyroid Neoplasms / Q000235:genetics*; D014157:Transcription Factors
C000715470:MAS1 protein, human; C111382:NCOA4 protein, human; D056918:Nuclear Receptor Coactivators; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D000090063:Proto-Oncogene Mas; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases; C093573:ret-PTC fusion oncoproteins, human