title: [Experimental trials of temporary insertion of removable catheter into artery for postoperative prophylactic hepatic arterial infusion chemotherapy].
abstract: We often experience hepatic metastases after resections for advanced gastrointestinal cancers. Various methods such as resection and hepatic arterial infusion chemotherapy are used when a metastatic tumor is detected on imagings. We have considered postoperative prophylactic hepatic arterial infusion chemotherapy for the prevention of heterochronous hepatic metastases. For this purpose, we conducted experimental trials of temporary insertion of a catheter, which we would be able to remove safely in the near future, into an artery. Laparotomy was done on rabbits under general anesthesia, and a 16 G catheter was inserted into the left renal artery. The proximal site of the artery and the catheter were ligated together with Elastik, and the catheter was fixed with coated VICRYL RAPIDE distal of the insertion point. Upon insertion of the catheters, there was no bleeding, and neither occlusion nor dislocation of the catheter occurred. Two weeks later, the catheters were easily removed without bleeding under laparotomy. At a second-look laparotomy after 2 more weeks, there were no abnormal findings such as hematomas. Therefore, we concluded that our method would be acceptable for the temporary catheter insertion into an artery which could be removed safely and easily when the chemotherapy was finished.
authors.affiliation: First Dept. of Surgery, Tokyo Medical and Dental University, School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Takamatsu
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D000818:Animals; D002404:Catheterization; D020878:Device Removal; D006499:Hepatic Artery; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D008113:Liver Neoplasms / Q000517:prevention & control*; D011182:Postoperative Care; D011817:Rabbits