The association of birth interval, maternal age and season of birth with the fertility of daughters: a retrospective cohort study based on family reconstitutions from nineteenth and early twentieth century Quebec.
In a historical follow-up study, we evaluated the association of the fertility of daughters with five perinatal factors: short (< 15 months) or long (> or = 45 months) preceding birth interval, low (< or = 20 years) or advanced (> or = 40 years) maternal age and season of birth. We used data concerning 2062 women married before the age of 31 and born in the Saguenay region of Quebec, Canada, between 1850 and 1899. Time between the wedding and first birth was used for the estimation of differences in fertility. Using logistic regression and controlling for several potential confounders, we found a slightly increased risk of monthly failure of conception for daughters born after a short but not for those born after a long birth interval (odds ratios [ORs] 1.09 [0.89, 1.33] and 0.87 [0.65, 1.16], respectively, with intervals between 21 and 32 months as the reference category). A slightly increased risk of conceptive failure was also seen for daughters of younger and older mothers (ORs 1.08 [0.89, 1.30] and 1.11 [0.91, 1.35], respectively, compared with maternal age between 24 and 30 years as the reference category). Fertility varied by season of birth (P = 0.02), with summer-born daughters having lowest and winter-born daughters having highest fertility. These results are consistent with the idea that maternal factors before or around birth play a role in the aetiology of reduced fertility. The data, however, do not unequivocally support the hypothesis that gave rise to the present study, namely that ovarian development may be disturbed after conception in conditions with an increased risk of maternal menstrual cycle irregularities.
Smits
L
L
Department of Epidemiology, University of Nijmegen, The Netherlands. Luc.Smits@rivm.nl
Zielhuis
G
G
Jongbloet
P
P
Bouchard
G
G
D000293:Adolescent; D000328:Adult; D001721:Birth Intervals; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology*; D008423:Maternal Age; D008597:Menstrual Cycle / Q000502:physiology; D010053:Ovary / Q000254:growth & development / Q000502:physiology; D011792:Quebec / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018570:Risk Assessment; D012621:Seasons