[Thrombopenia and acute renal insufficiency after treatment with streptokinase. Role of steroids].
Proteinuria is common after streptokinase treatment. An immunological mechanism in the renal glomerulus has been suggested to explain this side effect. However, thrombopenia and acute renal failure streptokinase induced are uncommon. We present a case of thrombopenia and acute renal failure after streptokinase administration for myocardial infarction that improved with steroid therapy. We discuss the probable pathophysiology of these adverse effects of streptokinase and the potential usefulness of steroids in its prevention and treatment.
Esplugas
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D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000328:Adult; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013300:Streptokinase / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy
D005343:Fibrinolytic Agents; D005938:Glucocorticoids; D013300:Streptokinase