Lack of association between a human beta-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity.
OBJECTIVE
To determine the frequency of the gln27glu polymorphism in the beta-2 adrenoceptor gene in patients with morbid obesity.


METHODS
243 patients with morbid obesity (mean body mass index 51. 6) and 199 healthy blood donors.


RESULTS
The same frequency, 0.42, of the glu allele was observed in both groups. Neither the incidence in obese women (0.41, n=197) compared to control women (0.43, n=61), nor that in obese men (0.44, n=46) compared to control men (0.41, n=138) was significantly different. The difference in frequency between obese men and women, 0.44 vs 0.41 was not significant (P=0. 68). Genotype information from the families of 18 of the obese patients showed no association between the glu27 allele and BMI.


CONCLUSIONS
We find no evidence for a role of the glu27 variant in the beta-2 adrenoceptor gene in the development of morbid obesity.
Kortner
B
B
Klinik für Allgemeinchirurgie, Evangelisches und Johanniter Klinikum, Dinslaken, Germany.
Wolf
A
A
Wendt
D
D
Beisiegel
U
U
Evans
D
D
D000483:Alleles; D015992:Body Mass Index; D004247:DNA / Q000097:blood; D005260:Female; D018698:Glutamic Acid / Q000235:genetics; D005973:Glutamine / Q000235:genetics; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
D018343:Receptors, Adrenergic, beta-2; D005973:Glutamine; D018698:Glutamic Acid; D004247:DNA