title: High expression of MHC I in the tibialis anterior muscle of a paraplegic patient.
abstract: A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy.
authors.affiliation: Center for Spinal Cord Injured, The Neuroscience Center, H:S Rigshospitalet, Copenhagen University Hospitals, Copenhagen, Denmark. hartkopp@dadlnet.dk
authors.forename: A
authors.initials: A
authors.lastname: Hartkopp
authors.forename: J L
authors.initials: JL
authors.lastname: Andersen
authors.forename: S D
authors.initials: SD
authors.lastname: Harridge
authors.forename: C
authors.initials: C
authors.lastname: Crone
authors.forename: T
authors.initials: T
authors.lastname: Gruschy-Knudsen
authors.forename: M
authors.initials: M
authors.lastname: Kjaer
authors.forename: M
authors.initials: M
authors.lastname: Masao
authors.forename: A
authors.initials: A
authors.lastname: Ratkevicius
authors.forename: B
authors.initials: B
authors.lastname: Quistorff
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: F
authors.initials: F
authors.lastname: Biering-Sørensen
mesh_terms: D004576:Electromyography; D006801:Humans; D007150:Immunohistochemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D018995:Myosin Heavy Chains / Q000096:biosynthesis*; D010264:Paraplegia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D020033:Protein Isoforms / Q000096:biosynthesis; D013119:Spinal Cord Injuries / Q000378:metabolism; D013977:Tibia
chemical_list: D020033:Protein Isoforms; D018995:Myosin Heavy Chains