title: Dexmedetomidine reduces seizure threshold during enflurane anaesthesia in cats.
abstract: Dexmedetomidine is an alpha 2 agonist and has been reported to have proconvulsant actions. To investigate the interaction of dexmedetomidine with convulsant anaesthetics, we studied effects on seizure threshold in cats during enflurane anaesthesia. Cats were prepared with chronic implantation of electrodes for recording of the cortical electroencephalogram (EEG) and midbrain reticular formation multi-unit activity (R-MUA). Seizure threshold, the reciprocal of the number of electrical stimuli required to induce generalized EEG seizure activity x 1000 (seizure induction index (SII)), was assessed. The effects of dexmedetomidine 1, 10 and 100 micrograms kg-1 i.v. and yohimbine 500 micrograms kg-1, an alpha 2 antagonist, on SII during 3.5% enflurane anaesthesia were investigated. Dexmedetomidine significantly increased SII at 10 and 100 micrograms kg-1, and this effect was reversed by yohimbine. We found that high-dose dexmedetomidine reduced seizure threshold during enflurane anaesthesia.
authors.affiliation: Department of Anaesthesia, Kyoto University Hospital, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Adachi
authors.forename: J
authors.initials: J
authors.lastname: Kurata
authors.forename: J
authors.initials: J
authors.lastname: Utsumi
authors.forename: T
authors.initials: T
authors.lastname: Shichino
authors.forename: H
authors.initials: H
authors.lastname: Segawa
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D002415:Cats; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D004737:Enflurane / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D018712:Analgesics, Non-Narcotic; D018685:Anesthetics, Inhalation; D015016:Yohimbine; D020927:Dexmedetomidine; D004737:Enflurane