title: Solvent oriented hobbies and the risk of systemic sclerosis.
abstract: OBJECTIVE
  To examine whether those participating in solvent oriented hobbies (SOH) are at greater risk of developing systemic sclerosis (SSc), and if the association is modified by the presence of the anti-Scl70 antibody.
  
  
  METHODS
  Patients with SSc and controls were recruited from a university hospital rheumatology clinic. Recreational hobby and occupational histories were obtained along with blood samples. Cumulative scores were created for participation in SOH. Logistic regression was used to calculate odds ratios associated with SOH exposure after adjustment for sex, age at diagnosis, and occupational solvent exposure, and to examine the association between SOH exposure and the presence of anti-Scl70.
  
  
  RESULTS
  Solvent exposure based on hobbies and occupations was determined for 178 cases (141 women, 37 men) and 200 controls (138 women, 62 men). Overall participation in SOH was not associated with SSc. However, odds of high cumulative SOH exposure was 3 times greater in those patients with SSc testing positive for the anti-Scl70 antibody compared to patients testing negative (OR 2.9, 95% CI 1.1, 7.9), and twice as great as controls (OR 2.5, 95% CI 1.1, 5.9).
  
  
  CONCLUSIONS
  While patients with SSc did not participate more often in SOH than controls over all, odds of high cumulative SOH exposure was greater among patients with SSc testing positive for anti-Scl70 compared to those testing negative and compared to controls. These results provide further evidence that environmental agents may play a role in the development of Ssc.
authors.affiliation: Center for Health Care Research, and Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425, USA. nieterpj@musc.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Nietert
authors.forename: S E
authors.initials: SE
authors.lastname: Sutherland
authors.forename: R M
authors.initials: RM
authors.lastname: Silver
authors.forename: J P
authors.initials: JP
authors.lastname: Pandey
authors.forename: M
authors.initials: M
authors.lastname: Dosemeci
mesh_terms: D005260:Female; D006686:Hobbies; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000453:epidemiology; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents