title: A new approach to the synthesis of efaroxan.
abstract: Efaroxan was synthetised by cyclisation of the tertiary alcohol 2 which was prepared by the ring opening of the gem-disubstituted epoxide 3 with ortho-metallated fluorobenzene.
authors.affiliation: Laboratoire de Synthèse Bio-Organique, CNRS et Université Louis Pasteur, Faculté de Pharmacie 74, Illkirch-Graffenstaden, France.
authors.forename: K
authors.initials: K
authors.lastname: Couture
authors.forename: V
authors.initials: V
authors.lastname: Gouverneur
authors.forename: C
authors.initials: C
authors.lastname: Mioskowski
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis*
chemical_list: D000317:Adrenergic alpha-Antagonists; D001572:Benzofurans; D004852:Epoxy Compounds; D007093:Imidazoles; C062597:efaroxan