title: Expression of Frzb-1 during chick development.
abstract: We cloned the chick homolog of Xenopus and mouse Frzb-1, a secreted Wnt antagonist and performed in situ hybridizations to determine the pattern of cFrzb-1 expression in the developing chick embryo. At early stages, cFrzb-1 transcripts are located exclusively in the ectodermal layer corresponding to the neural plate. The labelling continues in the neural tube, but is always excluded from the floor plate. cFrzb-1 mRNA is expressed by migrating cephalic and truncal neural crest cells. Later, cFrzb-1 transcripts are found in a subset of neural crest derivatives such as cephalic cartilage, nerves and spinal ganglia. In addition to ectodermal derivatives, cFrzb-1 transcripts were also observed in mesodermal derivatives such as vertebral and limb cartilage, the adrenal cortex, the gonads, and a subpopulation of blood cells.
authors.affiliation: Institut D'Embryologie Cellulaire et Moleculaire du CNRS (UPR 9024) et du College de France, 49 bis avenue de Ia Belle Gabrielle, 94736 Nogent-sur-Marne, Cedex, France. duprez@infobiogen.fr
authors.forename: D
authors.initials: D
authors.lastname: Duprez
authors.forename: L
authors.initials: L
authors.lastname: Leyns
authors.forename: M A
authors.initials: MA
authors.lastname: Bonnin
authors.forename: F
authors.initials: F
authors.lastname: Lapointe
authors.forename: H
authors.initials: H
authors.lastname: Etchevers
authors.forename: E M
authors.initials: EM
authors.lastname: De Robertis
authors.forename: N
authors.initials: N
authors.lastname: Le Douarin
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology; D002642:Chick Embryo; D003001:Cloning, Molecular; D004625:Embryo, Nonmammalian / Q000637:transplantation; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D008648:Mesoderm; D051379:Mice; D008969:Molecular Sequence Data; D009420:Nervous System / Q000196:embryology*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D011784:Quail / Q000196:embryology; D017386:Sequence Homology, Amino Acid; D000099274:Frizzled-Related Proteins
chemical_list: D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D000099274:Frizzled-Related Proteins