title: Right ventricular function after pulmonary autograft replacement of the aortic valve.
abstract: BACKGROUND
  The pulmonary autograft operation (the Ross procedure) involves excision of a portion of the right ventricular (RV) outflow tract, prolonged cross-clamp times, and insertion of a pulmonary homograft. There is concern about the effect of such operations on right ventricular function.
  
  
  RESULTS
  Twenty-five patients undergoing either pulmonary autograft or homograft replacement of the aortic valve as part of a prospective randomized trial had echocardiographic RV long-axis measurements performed before surgery and 6 months (range 3 to 12 months) after surgery. In all patients, systolic excursion (SE) and both shortening and lengthening rates (SR and LR, respectively) were reduced postoperatively (P<0.05) (homografts: SE 1.5+/-0.4 versus 2.3+/-0.6 cm, SR 6.8+/-2.1 versus 9. 6+/-3.1 cm/s, LR 6.0+/-1.8 versus 8.9+/-3.0 cm/s; autografts: SE 1. 4+/-0.4 versus 2.2+/-0.4 cm, SR 5.8+/-3.0 versus 8.2+/-3.0 cm/s, LR 5.7+/-1.9 versus 8.5+/-3.7 cm/s). There were no differences between the 2 groups. Eighteen patients who had undergone either aortic homograft or pulmonary autograft surgery were studied between 6 and 35 months after surgery. RV volumes were assessed with the use of MRI in addition to echocardiographic RV long-axis measurements. Global volumes were increased to a similar amount in both groups (homografts: end-diastolic volume 145+/-34 mL, end-systolic volume 78+/-23 mL; autografts: end-diastolic volume 157+/-33 mL, end-systolic volume 89+/-25 mL; P=NS), whereas stroke volumes were maintained in both groups (homografts 67+/-15 mL, autografts 67+/-16 mL; P=NS). RV SE was depressed in both groups to a similar degree to that seen with the previous group (homografts 1.5+/-0.3 cm, autografts 1.4+/-0.2 cm).
  
  
  CONCLUSIONS
  Aortic valve replacement with either a pulmonary autograft or an aortic homograft leads to a degree of persistent RV longitudinal dysfunction that is not more pronounced in those undergoing the Ross procedure. The mechanisms and long-term effects of these changes must be further studied.
authors.affiliation: Department of Academic Surgery, National Heart and Lung Institute, Royal Brompton Hospital, London, UK. g.carr-white@rbh.nthames.nhs.uk
authors.forename: G S
authors.initials: GS
authors.lastname: Carr-White
authors.forename: M
authors.initials: M
authors.lastname: Kon
authors.forename: T W
authors.initials: TW
authors.lastname: Koh
authors.forename: S
authors.initials: S
authors.lastname: Glennan
authors.forename: F D
authors.initials: FD
authors.lastname: Ferdinand
authors.forename: A C
authors.initials: AC
authors.lastname: De Souza
authors.forename: J R
authors.initials: JR
authors.lastname: Pepper
authors.forename: D J
authors.initials: DJ
authors.lastname: Pennell
authors.forename: D G
authors.initials: DG
authors.lastname: Gibson
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008168:Lung / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014182:Transplantation, Autologous; D016278:Ventricular Function, Right