title: Pigmented squamous cell carcinoma with dendritic melanocyte colonization in the external auditory canal.
abstract: A case of pigmented squamous cell carcinoma (SCC) with dendritic melanocyte colonization in the external auditory canal is reported and the previous cases are reviewed. A 65-year-old Japanese female was referred with a 7-year history of otitis. The patient also had a darkly pigmented 9 x 8 mm nodule in the external auditory canal. Microscopically, the tumor was SCC, but in some areas melanin pigments were found in the cytoplasm of the tumor cells. The tumor was thus diagnosed as pigmented SCC. As well as the tumor cells, dendritic-shaped cells colonized the tumor parenchyma and were immunohistochemically defined as melanocytes. The authors believe this is the first case of pigmented SCC with dendritic melanocyte colonization in the external auditory canal.
authors.affiliation: First Department of Pathology, Gunma University School of Medicine, Maebashi, Japan. mkamiya@sb.gunma-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Kamiya
authors.forename: R
authors.initials: R
authors.lastname: Maehara
authors.forename: S
authors.initials: S
authors.lastname: Iizuka
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Yamanouchi
authors.forename: H
authors.initials: H
authors.lastname: Yokoo
authors.forename: A
authors.initials: A
authors.lastname: Sasaki
authors.forename: J
authors.initials: J
authors.lastname: Hirato
authors.forename: Y
authors.initials: Y
authors.lastname: Nakazato
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D004428:Ear Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*; D016622:Silver Staining
chemical_list: D014408:Biomarkers, Tumor