title: Comparison of Gadomer-17 and Gd-DTPA in image quality of contrast-enhanced MR angiographies using flow phantom model.
abstract: The purpose of this study was to compare the image quality of 3D-TOF MR angiography (MRA) using Gadomer-17 with that using Gd-DTPA in a flow phantom model, and to present preliminary data about the proper dose concentration of Gadomer-17. In the visual analysis of vessel conspicuity, we compared the quality of pre- and post-contrast MIP images. For quantitative analysis, the signal intensities were measured in the axial base 3D-TOF images, and then the relative contrast enhancement was calculated. The results of our studies were that: 1. Maximal signal intensities were obtained at 1 mmol/L of Gadomer-17 and 4 mmol/L of Gd-DTPA. 2. Flow-related signal loss was decreased by Gd-DTPA proportional to the concentration, but Gadomer-17 did not show such a dose accumulative effect. In conclusion, after comparing the results of Gd-DTPA, it was clear that improved MRA images and higher signal intensities of vessels were obtained when lower concentrations of Gadomer-17 were used.
authors.affiliation: Department of Diagnostic Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: B J
authors.initials: BJ
authors.lastname: Jo
authors.forename: T S
authors.initials: TS
authors.lastname: Chung
authors.forename: M S
authors.initials: MS
authors.lastname: Lee
authors.forename: J Y
authors.initials: JY
authors.lastname: Joo
authors.forename: W
authors.initials: W
authors.lastname: Ebert
authors.forename: H J
authors.initials: HJ
authors.lastname: Weinmann
authors.forename: D
authors.initials: D
authors.lastname: Chien
authors.forename: G
authors.initials: G
authors.lastname: Laub
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography
chemical_list: D003287:Contrast Media; C402765:gadomer 17; D005682:Gadolinium; D019786:Gadolinium DTPA