title: An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase.
abstract: Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
authors.affiliation: Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, QC, H3C 3J7 (Canada).
authors.initials: S
authors.lastname: Hanessian
authors.initials: PP
authors.lastname: Lu
authors.initials: JY
authors.lastname: Sancéau
authors.initials: P
authors.lastname: Chemla
authors.initials: K
authors.lastname: Gohda
authors.initials: R
authors.lastname: Fonne-Pfister
authors.initials: L
authors.lastname: Prade
authors.initials: SW
authors.lastname: Cowan-Jacob