title: Elimination of non-ionic contrast medium by hemodialysis in patients with impaired renal function.
abstract: The elimination rate of iohexol, a non-ionic contrast medium, from the blood by hemodialysis, and the elimination rate of iohexol by a dialyzer were studied in 15 patients with chronic renal dysfunction who required angiography or enhanced CT. The elimination rate of iohexol was 19.8% at 15 min after the start of hemodialysis, 30.6% after 30 min, 44.2% after 1 hour, 62.1% after 2 hours and 72.9% after 3 hours. The dialyzer elimination rate was maintained at about 75% from 1 to 3 hours after the start of hemodialysis. If only about 70% of iohexol in the blood needs to be eliminated, hemodialysis for 3 hours with a blood flow rate of 120 ml/min and a dialysate flow of 500 ml/min using a 0.7 m2 cellulose triacetate membrane is sufficient.
authors.affiliation: Department of Urology, Nippon Medical School, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Horiuchi
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: N
authors.initials: N
authors.lastname: Tsuboi
authors.forename: M
authors.initials: M
authors.lastname: Akimoto
authors.forename: H
authors.initials: H
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Kumazaki
mesh_terms: D003287:Contrast Media / Q000302:isolation & purification* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007472:Iohexol / Q000302:isolation & purification* / Q000493:pharmacokinetics; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D003287:Contrast Media; D007472:Iohexol