title: Assessment of cognitive function in asymptomatic HIV-positive subjects.
abstract: This retrospective study aims to assess cognitive involvement in pre-AIDS, not drug abuser subjects and to determine whether CD4 status or disease stage best correlates with cognitive changes that may portend development of ADC. 328 cases were analyzed. No differences in psychometric performance in relation to CDC stage were found. Instead, patients with CD4 < 200/microl performed worse overall, with a statistically significant difference for Digit Symbol, Corsi Test, Block Design and HIVDA Scale. Even if cognitive decline is not evident in the early phase of HIV infection, CD4 count seems the more sensitive early indicator of cognitive changes adequately pointed out by the HIVDA Scale, which could be considered a useful screening tool for cognitive deficit.
authors.affiliation: I Clinica Neurologica, Ospedale L. Sacco, Milano, Italy. neurdept@imiucca.csi.unimi.it
authors.forename: M P
authors.initials: MP
authors.lastname: Grassi
authors.forename: C
authors.initials: C
authors.lastname: Perin
authors.forename: M
authors.initials: M
authors.lastname: Borella
authors.forename: A
authors.initials: A
authors.lastname: Mangoni
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000209:etiology / Q000523:psychology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D003072:Cognition Disorders / Q000175:diagnosis* / Q000821:virology; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis / Q000523:psychology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales / Q000592:standards; D012189:Retrospective Studies; D012494:Sampling Studies