The anti-arrhythmia properties of the functional opioid agonist orphanin FQ (nociceptin).
It was shown that the agonist of peripheral ORL1 receptors nociceptine raises heart resistance to the antiarrhythmic effect of aconitine. The antiarrhythmic effect of nociceptine is not connected with a change in the tonus of the autonomous nervous system or with an effect on opiate receptors. It is assumed that the antiarrhythmic properties of nociceptine are realized through inhibition of Na+/Ca2+ metabolism or blockade of rapid Na(+) channels of the cardiomyocytes.
Maslov
L N
LN
Department of Experimental Cardiology, Institute of Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
Krylatov
A V
AV
Lishmanov
Iu B
IuB
Albrecht
E
E
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D002122:Calcium Chloride; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D004837:Epinephrine; D008297:Male; D018847:Opioid Peptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists*; D013997:Time Factors; D000094942:Nociceptin Receptor; D000097629:Nociceptin
D000157:Aconitine; D000889:Anti-Arrhythmia Agents; D002122:Calcium Chloride; D004837:Epinephrine; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722285:Oprl1 protein, rat