title: Lymph-node-based malignant lymphoma and reactive lymphadenopathy in eosinophilic fasciitis.
abstract: BACKGROUND
  Lymph node enlargement in patients with eosinophilic fasciitis is a rare occurrence and its clinical significance is unknown.
  
  
  METHODS
  The literature and authors' registries were searched for eosinophilic fasciitis associated with lymphadenopathy. Clinical data, time sequence of appearance of either disorder, and pathological diagnoses were analyzed.
  
  
  RESULTS
  Six patients presenting with eosinophilic fasciitis had a lymph-node-based lymphoma and 4 patients had a reactive lymphadenopathy. The patients with lymphoma were elderly and the subcutaneous induration preceded the lymphadenopathy by 2 to 36 months. The patients with eosinophilic fasciitis and reactive lymphadenopathy were young and the onset of subcutaneous induration and lymph node enlargement coincided with one another. Favorable response of the eosinophilic fasciitis to prednisone therapy was attained in 3 of 3 patients with reactive lymphadenopathy and in 4 of the 6 cases with lymphoma.
  
  
  CONCLUSIONS
  Eosinophilic fasciitis is rarely associated with clinically significant lymph node enlargement. Subcutaneous induration preceding the lymphadenopathy by 6 months or more, especially in elderly patients, suggests an underlying lymphoma. A favorable response of the subcutaneous induration to prednisone treatment does not exclude the diagnosis of lymphoma; therefore, it does not supersede the need of a pathological evaluation. A lymph node biopsy is mandatory in all cases.
authors.affiliation: Department of Internal Medicine, Bnai-Zion Medical Center, Haifa, Israel.
authors.forename: J E
authors.initials: JE
authors.lastname: Naschitz
authors.forename: I
authors.initials: I
authors.lastname: Misselevich
authors.forename: I
authors.initials: I
authors.lastname: Rosner
authors.forename: D
authors.initials: D
authors.lastname: Yeshurun
authors.forename: P
authors.initials: P
authors.lastname: Weiner
authors.forename: M
authors.initials: M
authors.lastname: Amar
authors.forename: L
authors.initials: L
authors.lastname: Amato
authors.forename: M L
authors.initials: ML
authors.lastname: Ciompi
authors.forename: J H
authors.initials: JH
authors.lastname: Boss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004804:Eosinophils; D005208:Fasciitis / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology* / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged