Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus.
A biologically monitored fractionation of methanol extract of the fruit of Evodia rutaecarpa led to the isolation of six quinolone alkaloids, evocarpine (1), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolo ne (3), 1-methyl-2-undecyl-4(1H)-quinolone (4), dihydroevocarpine (5), 1-methyl-2-pentadecyl-4(1H)-quinolone (6). They showed potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. However, they had no effect on Helicobacter pylori urease activity at the concentration of 300 microg/ml.
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Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.
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Kim
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Kim
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Ahn
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Lee
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D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000302:isolation & purification / Q000494:pharmacology; D019685:Rosales / Q000737:chemistry*; D014510:Urease / Q000037:antagonists & inhibitors / Q000378:metabolism
D000890:Anti-Infective Agents; D015363:Quinolones; C059242:evocarpine; D014510:Urease