title: Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine.
abstract: Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was made by the agar dilution method against 28 pathogenic bacteria, eight pathogenic fungi and anti-HIV activity against replication of HIV-1 (III B) in MT-4 cells. The compounds are significantly active against bacteria and fungi.
authors.affiliation: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India. snpande@banaras.ernet.in
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: D
authors.initials: D
authors.lastname: Sriram
authors.forename: G
authors.initials: G
authors.lastname: Nath
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007510:Isatin / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008352:Mannich Bases; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases; D013057:Spectrum Analysis; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D008352:Mannich Bases; D012545:Schiff Bases; D007510:Isatin