[Relationship between alcoholism and HTR2 MspI polymorphism].
We investigated the human serotonin receptor, HTR2 genotype among 73 alcoholics. We found that there might not be a significant difference between alcoholics and controls in the frequency of HTR2 C1/C2 gene (MspI polymorphism). This result suggested that the HTR2 C1/C2 gene might not be associated with the risk factor for developing alcohol dependence. Further studies are required to determine whether or not a novel serotonin receptor polymorphism reflects pathogenesis of alcoholism.
Yoshihara
E
E
Department of Physiology, Azabu University, Sagamihara, Japan.
Iwahashi
K
K
Ameno
K
K
Nakamura
K
K
Ito
M
M
Enomoto
M
M
Ijiri
I
I
Harada
S
S
D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics*; D012307:Risk Factors
D011985:Receptors, Serotonin