title: [A case report: successful resection of advanced intrahepatic cholangiocarcinoma responding to preoperative hepatic artery infusion of 5-FU].
abstract: A patient with advanced intrahepatic cholangiocarcinoma had a tumor embolus in the right main branch of the portal vein and lymph node metastases. Hepatic arterial infusion (HAI) therapy with 5-FU (1 g/day) was given as a continuous infusion for 6 days. The treatment was repeated after a one-week interval. As a result the tumor diameter decreased by half, and the tumor embolus contracted. Cytoreductive surgery was then performed. The patient has been disease-free for over 9 months postoperatively with adjuvant HAI with 5-FU. We consider preoperative HAI with 5-FU (two courses of 1 g/day x 6 days) is both safe and effective.
authors.affiliation: Dept. of Surgery, Osaka National Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Hasuike
authors.forename: M
authors.initials: M
authors.lastname: Motoori
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: J
authors.initials: J
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Mishima
authors.forename: T
authors.initials: T
authors.lastname: Sawamura
authors.forename: I
authors.initials: I
authors.lastname: Nishishou
authors.forename: N
authors.initials: N
authors.lastname: Kikkawa
authors.forename: H
authors.initials: H
authors.lastname: Sai
authors.forename: T
authors.initials: T
authors.lastname: Hosoki
authors.forename: M
authors.initials: M
authors.lastname: Mitomo
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D011300:Preoperative Care
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil