Cerium(IV)-Catalyzed Deprotection of Acetals and Ketals under Mildly Basic Conditions.
Smooth and quantitative deprotection of a wide range of acetals and ketals [Eq. (a); R, R(1)=alkyl, aryl, H] under neutral to mildly basic conditions was achieved with catalytic quantities of cerium ammonium nitrate (CAN). The reaction conditions are compatible with a variety of sensitive functional groups, and aldehydes can be liberated from acetals without being oxidized to the corresponding carboxylic acids.
Markó
IE
Université catholique de Louvain, Département de Chimie, Laboratoire de Chimie Organique Batiment Lavoisier, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve (Belgium).
Ates
A
Gautier
A
Leroy
B
Plancher
JM
Quesnel
Y
Vanherck
JC