title: Familial mixed tumors of the parotid gland.
abstract: BACKGROUND
  The most common neoplasm of the parotid gland is the pleomorphic adenoma. The familial occurrence of such tumors arising within the parotid gland is rare, with only 3 previous reports in the literature. Bilateral synchronous pleomorphic adenomas of the parotid gland are also uncommon. We report 2 siblings with pleomorphic adenomas of the parotid gland, 1 of whom had bilateral synchronous mixed tumors. Patients and Methods Chromosomal analysis of tumor cells from the sibling with bilateral adenomas revealed the translocation t(3;12)(p21;q15). Chromosome 12q breakpoints have previously been identified in a wide variety of solid tumors including pleomorphic adenomas of the parotid gland.
  
  
  CONCLUSIONS
  We discuss bilateral mixed tumors, familial parotid tumors, and the potential for a genetic predisposition for the recurrence of such parotid tumors, as suggested by characteristic chromosomal translocations associated with mixed tumors.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, Suite A730, San Francisco, California 94117, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Ahn
authors.forename: G M
authors.initials: GM
authors.lastname: Hayashi
authors.forename: R L
authors.initials: RL
authors.lastname: Hilsinger
authors.forename: A K
authors.initials: AK
authors.lastname: Lalwani
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002881:Chromosomes, Human, Pair 12; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic