[Cardio vascular disease associated with ulcerative colitis].
Although cardiovascular complications such as Aortic syndrome (Takayasu's aortitis), Pericarditis and Myopericarditis might not be common, these complications should be noted as one of the fatal manifestation of IBD. It can be the sole or one of the several extraintestinal manifestation of either ulcerative colitis or Crohn's disease. Because of the therapeutic implications, we reviewed the literature documenting cardiovascular complication associated with ulcerative colitis. The comparatively high prevalence of Takayasu's aortitis with ulcerative colitis in Japanese patients may be explained by a immune genetic influence. HLA-B52 and DR2, were highly expressed in the patient with both disease. Myopericarditis and Pleuropericarditis associated with IBD were divided into two groups by pathogenesis, 1) drug (5-ASA)-induced disease, and 2) autoimmune disease. The cardiovascular symptom may occur while the patient's gastrointestinal disease is quiescent.
Iizuka
B
B
Division of Internal Medicine, Tokyo Women's Medical University.
Yamagishi
N
N
Honma
N
N
Hayashi
N
N
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects; D009205:Myocarditis / Q000209:etiology; D010493:Pericarditis / Q000209:etiology; D012460:Sulfasalazine / Q000009:adverse effects; D013625:Takayasu Arteritis / Q000209:etiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015235:HLA-B Antigens; D059950:HLA-B52 Antigen; D015802:HLA-DR2 Antigen; D012460:Sulfasalazine; D019804:Mesalamine