title: Current knowledge in the management of children and adolescents with sickle cell disease: Part 1, Physiological issues.
abstract: This article reviews the current state of the knowledge in the management of children and adolescents with sickle cell disease (SCD). A thorough review of the literature concerning physiological issues including the clinical manifestations of SCD as well as current treatment modalities is included. Therapeutic management of health and illness for a child with SCD is discussed in relation to primary, secondary, and tertiary prevention. Recommendations for nursing practice and research are made.
authors.affiliation: College of Nursing, University of South Carolina, Charleston 29425, USA.
authors.forename: K
authors.initials: K
authors.lastname: Simon
authors.forename: M L
authors.initials: ML
authors.lastname: Lobo
authors.forename: S
authors.initials: S
authors.lastname: Jackson
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000451:nursing / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008403:Mass Screening; D015399:Nursing Research; D010146:Pain / Q000209:etiology; D059408:Pain Management; D011322:Primary Prevention; D012131:Respiratory Insufficiency / Q000209:etiology