[Dopamine antibodies: effect on the "open field" behavior, pain sensitivity, monoamine levels in the central nervous system, and functional activity of immunocytes in C57Bl/6 mice].
Dopamine antibodies (AB) were singularly injected to C57B1/6 mice intraperitoneally. The locomotor activity in the open field was suppressed for 5 days in the majority of the animals. Hyperalgesia revealed 1.5 h and 1 day after the AB injection changed for analgesia on the 5th day. A sharp reduction of the brain level of dopamine and its metabolite was revealed 1 and 5 days after the AB injection, the serotonin content was increased within 1 day and decreased within 5 days after the injection. No action of the AB on cells of the immune system was observed. The possible mechanisms of the AB neurotropic action are discussed.
Trekova
N A
NA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Vetrilé
L A
LA
Basharova
L A
LA
Mikovskaia
O I
OI
Khlopushina
T G
TG
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000276:immunology / Q000378:metabolism*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism; D015213:Neuroimmunomodulation; D010147:Pain Measurement / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects / Q000378:metabolism
D000906:Antibodies; D015306:Biogenic Monoamines; D004298:Dopamine