title: The oxetane conformational lock of paclitaxel: structural analysis of D-secopaclitaxel.
abstract: Analysis of the 1H NMR data of paclitaxel in comparison with its oxetane ring-opened analogue D-secopaclitaxel suggests that the oxetane moiety (D-ring) of paclitaxel serves as a conformational lock for the diterpene moiety and the C13 side chain.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Boge
authors.forename: M
authors.initials: M
authors.lastname: Hepperle
authors.forename: D G
authors.initials: DG
authors.lastname: Vander Velde
authors.forename: C W
authors.initials: CW
authors.lastname: Gunn
authors.forename: G L
authors.initials: GL
authors.lastname: Grunewald
authors.forename: G I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel