title: [Evaluation of the biocompatibility of grafts for bone defects].
abstract: BACKGROUND
  This paper examines a new material composed of polylactic and polyglycolic acids mixed with destrane easy to handle in bone defect reconstruction in periodontology and implantology: its name is fisiograft.
  
  
  METHODS
  According to the European directives, fisiograft was checked for some biological tests selected for its specific use. In particular, tests of cytotoxicity, genotoxicity, sensitization and implantation in rabbit's femurs were carried out.
  
  
  RESULTS
  The results show that the composite material is not cytotoxic when it is in direct and indirect contact with murine fibroblasts. It is not genotoxic and not allergenic. The implantation in rabbit, already after 30 days, shows that around the material there is a rapid bone growth and the material is reabsorbing. The degradation is suitable for its clinical use.
  
  
  CONCLUSIONS
  Fisiograft showed to be biocompatible, easy to handle and its degradation kinetics in bone is appropriate.
authors.affiliation: Dipartimento di Chirurgia, Università degli Studi, Modena.
authors.forename: A
authors.initials: A
authors.lastname: Gatti
authors.forename: E
authors.initials: E
authors.lastname: Monari
authors.forename: D
authors.initials: D
authors.lastname: Tanza
authors.forename: V
authors.initials: V
authors.lastname: Betti
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D000541:Alveolectomy; D000543:Alveoloplasty / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials; D001862:Bone Resorption / Q000534:rehabilitation; D003602:Cytotoxicity, Immunologic; D003757:Dental Implantation / Q000295:instrumentation / Q000379:methods; D003758:Dental Implantation, Endosseous / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D019344:Lactic Acid / Q000494:pharmacology; D010510:Periodontal Diseases / Q000601:surgery; D011100:Polyglycolic Acid / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D011100:Polyglycolic Acid; D019344:Lactic Acid