title: Comparison of 24 hour control with Timoptic 0.5% and Timoptic-XE 0.5% in exfoliation and primary open-angle glaucoma.
abstract: OBJECTIVE
  To compare the 24 hour intraocular pressure (IOP) curve in exfoliation glaucoma (EXG) and primary open-angle glaucoma (POAG) patients treated first with timolol solution 0.5% (TS) twice daily and then with timolol maleate gel forming solution 0.5% (TXE) once daily.
  
  
  METHODS
  We prospectively investigated age-matched, newly diagnosed EXG (n = 25) and POAG (n = 25) patients who were admitted as in-patients for 24 hour phasing first with TS and then TXE.
  
  
  RESULTS
  Generally TS and TXE controlled both POAG and EXG patients in a similar fashion. However, a trend to lower pressures was observed in both EXG and POAG patients with TS therapy. At two time points (10:00 and 22:00) in POAG patients, TS (18.4 +/- 3.7 and 17.2 +/- 3.1 mm Hg, respectively) provided lower intraocular pressures than TXE (19.8 +/- 3.5 and 18.9 +/- 3.8 mm Hg, respectively) (p < 0.05).
  
  
  CONCLUSIONS
  Both TS twice daily and TXE once daily control POAG and EXG generally to a similar extent.
authors.affiliation: University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: A G
authors.initials: AG
authors.lastname: Konstas
authors.forename: D A
authors.initials: DA
authors.lastname: Mantziris
authors.forename: A
authors.initials: A
authors.lastname: Maltezos
authors.forename: E A
authors.initials: EA
authors.lastname: Cate
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D002940:Circadian Rhythm; D017889:Exfoliation Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013999:Timolol / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D013999:Timolol