Batch effects, water content and aqueous/organic solvent reactivity of microcrystalline cellulose samples.
The structural, morphological and surface features on two MCC powders of the same commercial type (Avicel PH 102), but coming from different countries (The Netherlands and Hong Kong) and vendors (DMV International and Mingtai Chemical Co., Ltd., respectively), have been investigated and compared, by means of the X-ray diffraction, SEM and BET and polymerization degree determination. TGA and water sorption from saturated vapor experiments have been applied to characterize and compare the MCC/water interactions of the two samples. The results were integrated by studies of preferential sorption from binary aqueous/organic solvents.
Ardizzone
S
S
Department of Physical Chemistry and Electrochemistry, University of Milan, Italy. sardizz@imiucca.unimi.it
Dioguardi
F S
FS
Mussini
P R
PR
Mussini
T
T
Rondinini
S
S
Vercelli
B
B
Vertova
A
A
D000097:Acetonitriles / Q000737:chemistry; D000327:Adsorption; D002482:Cellulose / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011208:Powders / Q000737:chemistry; D012997:Solvents / Q000737:chemistry*; D013696:Temperature; D013818:Thermogravimetry; D014867:Water / Q000032:analysis* / Q000737:chemistry
D000097:Acetonitriles; D004146:Dioxanes; D005079:Excipients; D011208:Powders; D012997:Solvents; D014867:Water; D000431:Ethanol; D002482:Cellulose; C025223:1,4-dioxane; C109691:microcrystalline cellulose; D000432:Methanol; C032159:acetonitrile