title: Brain correlates of memory dysfunction in alcoholic Korsakoff's syndrome.
abstract: OBJECTIVE
  To investigate the relation between anterograde amnesia and atrophy of brain structures involved in memory processing in alcoholic Korsakoff's syndrome.
  
  
  METHODS
  The volume of brain structures involved in memory processing was measured with MRI from 13 subjects with Korsakoff's syndrome, 13 subjects with chronic alcoholism without Korsakoff's syndrome, and 13 control subjects. The brain structures analysed were the hippocampus, the parahippocampal gyrus, the mamillary bodies, the third ventricle, and the thalamus. Brain volumes were correlated with the delayed recall of a verbal learning test.
  
  
  RESULTS
  Compared with subjects with chronic alcoholism and control subjects, subjects with Korsakoff's syndrome had a reduced volume of the hippocampus, the mamillary bodies, and the thalamus, and enlargement of the third ventricle. The impairment of delayed recall correlated with the volume of the third ventricle (r=-0.55, p=0.05) in the Korsakoff group.
  
  
  CONCLUSIONS
  Anterograde amnesia in alcoholic Korsakoff's syndrome is associated with atrophy of the nuclei in the midline of the thalamus, but not with atrophy of the mamillary bodies, the hippocampus, or the parahippocampal gyrus.
authors.affiliation: Institute of Brain and Behavior, Department of Psychiatry, University of Maastricht, Maastricht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Visser
authors.forename: L
authors.initials: L
authors.lastname: Krabbendam
authors.forename: F R
authors.initials: FR
authors.lastname: Verhey
authors.forename: P A
authors.initials: PA
authors.lastname: Hofman
authors.forename: W M
authors.initials: WM
authors.lastname: Verhoeven
authors.forename: S
authors.initials: S
authors.lastname: Tuinier
authors.forename: A
authors.initials: A
authors.lastname: Wester
authors.forename: Y W
authors.initials: YW
authors.lastname: Den Berg
authors.forename: L F
authors.initials: LF
authors.lastname: Goessens
authors.forename: Y D
authors.initials: YD
authors.lastname: Werf
authors.forename: J
authors.initials: J
authors.lastname: Jolles
mesh_terms: D000437:Alcoholism / Q000175:diagnosis; D020324:Amnesia, Anterograde / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D001284:Atrophy / Q000473:pathology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology; D006801:Humans; D020915:Korsakoff Syndrome / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D013787:Thalamic Nuclei / Q000473:pathology* / Q000503:physiopathology*