Thrombophilic factors and their relation to thromboembolic and other clinical manifestations in Behçet's disease.
OBJECTIVE
To evaluate the prevalence of thrombophilic factors known to induce intravascular clotting and to assess their relationship with thromboembolic complications and the other clinical manifestations in Behçet's disease (BD).


METHODS
Twenty-five patients with established BD were studied. Twenty patients with rheumatic conditions not known to be associated with venous or arterial thromboembolic phenomena served as controls. Eight of the patients with BD (32%) had either deep vein thrombosis (6 patients), arterial thromboembolic phenomena (2), or both (2). All participants were tested for IgG and IgM anticardiolipin antibody (aCL) levels, the presence of circulating lupus anticoagulant (LAC), protein C, protein S, and antithrombin III activity, activated protein C resistance, and where appropriate factor V Leiden mutation.


RESULTS
Elevated levels of IgG aCL were detected in 10 (40%) patients with BD compared to one (5%) in the control group (p = 0.012). No significant differences were noted in the other variables studied between the 2 groups. No statistically significant correlation was found between any variable and the clinical manifestations.


CONCLUSIONS
Patients with BD do not have decreased protein C, protein S, or antithrombin III activity, activated protein C resistance, circulating LAC, or elevated levels of IgM aCL. A significant number of patients have elevated levels of IgG aCL but they are not associated with venous or arterial thrombosis. No correlation was found between any variable and other clinical manifestations of the disease.
Mader
R
R
Department of Dermatology, Ha'Emek Medical Center, Afula, Israel.
Ziv
M
M
Adawi
M
M
Mader
R
R
Lavi
I
I
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000276:immunology; D000990:Antithrombin III / Q000378:metabolism; D001528:Behcet Syndrome / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D005165:Factor V / Q000378:metabolism; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D013923:Thromboembolism / Q000209:etiology* / Q000276:immunology / Q000378:metabolism
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005165:Factor V