title: Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging--clinicopathologic study.
abstract: OBJECTIVE
  To assess the efficacy of combined magnetic resonance (MR) imaging and three-dimensional (3D) proton MR spectroscopic imaging in the detection and localization of prostate cancer.
  
  
  METHODS
  MR imaging and 3D MR spectroscopic imaging examinations were performed in 53 patients with biopsy-proved prostate cancer and subsequent radical prostatectomy with step-section histopathologic examination. The prostate was divided into sextants. At MR imaging, the presence or absence of cancer in the peripheral zone of each sextant was assessed independently by two readers (readers 1 and 2) unaware of the findings at 3D MR spectroscopic imaging and histopathologic examination. At 3D MR spectroscopic imaging, cancer was diagnosed as possible if the ratio of choline plus creatine to citrate exceeded 2 SD above population norms or as definite if that ratio exceeded 3 SDs above the norm.
  
  
  RESULTS
  On the basis of sextants, sensitivity and specificity, respectively, for MR imaging were 77% and 61% (reader 1) and 81% and 46% (reader 2) with moderate interreader agreement (kappa = 0.43). The 3D MR spectroscopic imaging diagnosis of definite cancer had significantly higher specificity (75%, P < .05) but lower sensitivity (63%, P < .05). Receiver operating characteristic analysis showed significantly (P < .001) improved tumor localization for both readers when 3D MR spectroscopic imaging was added to MR imaging. High specificity (up to 91%) was obtained when combined MR imaging and 3D MR spectroscopic imaging indicated cancer, whereas high sensitivity (up to 95%) was obtained when either test alone indicated a positive result.
  
  
  CONCLUSIONS
  The addition of 3D MR spectroscopic imaging to MR imaging provides better detection and localization of prostate cancer in a sextant of the prostate than does use of MR imaging alone.
authors.affiliation: Department of Radiology, University of California at San Francisco 94143-0628, USA.
authors.forename: J
authors.initials: J
authors.lastname: Scheidler
authors.forename: H
authors.initials: H
authors.lastname: Hricak
authors.forename: D B
authors.initials: DB
authors.lastname: Vigneron
authors.forename: K K
authors.initials: KK
authors.lastname: Yu
authors.forename: D L
authors.initials: DL
authors.lastname: Sokolov
authors.forename: L R
authors.initials: LR
authors.lastname: Huang
authors.forename: C J
authors.initials: CJ
authors.lastname: Zaloudek
authors.forename: S J
authors.initials: SJ
authors.lastname: Nelson
authors.forename: P R
authors.initials: PR
authors.lastname: Carroll
authors.forename: J
authors.initials: J
authors.lastname: Kurhanewicz
mesh_terms: D003430:Cross-Sectional Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity