The anti-apoptotic actions of nitric oxide in hepatocytes.
Nitric oxide (NO) has anti-apoptotic actions in hepatocytes in vitro and in vivo. The protection is mediated via the S-nitrosylation of procaspases as well as the active caspase enzymes. NO stimulation of the cGMP/protein kinase G pathway also appears to contribute to the protective effect of NO. Here we review the evidence for the direct inhibition of NO with the apoptotic signaling pathways in hepatocytes.
Li
J
J
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Billiar
T R
TR
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D019610:Cytoprotection / Q000502:physiology*; D008099:Liver / Q000737:chemistry* / Q000166:cytology / Q000502:physiology*; D009569:Nitric Oxide / Q000737:chemistry* / Q000502:physiology*
D009569:Nitric Oxide