title: Eosinophilia during fludarabine treatment of chronic lymphocytic leukemia.
abstract: Although eosinophilia has been reported as a side effect of purine analogues, there is no report on fludarabine-induced eosinophilia in chronic lymphocytic leukemia (CLL). During chemotherapy with fludarabine and cyclophosphamide, we observed two cases of significant eosinophilia. A 67-year-old patient with CLL developed bone marrow and peripheral blood eosinophilia up to 7.9x10(9)/l, the highest eosinophil count ever reported during treatment with a purine analogue. The eosinophilia persisted for 33 days. Another patient developed bone marrow eosinophilia without eosinophilia in the peripheral blood. These are the first documented cases of fludarabine-induced eosinophilia in CLL, and this side effect may conceivably be more common than previously recognized.
authors.affiliation: Universitätsklinikum Charité, Department of Internal Medicine, Hematology/Oncology, D-10098 Berlin, Germany. sezer@charite.de
authors.forename: O
authors.initials: O
authors.lastname: Sezer
authors.forename: P
authors.initials: P
authors.lastname: Schmid
authors.forename: M
authors.initials: M
authors.lastname: Hallek
authors.forename: M
authors.initials: M
authors.lastname: Schweigert
authors.forename: T
authors.initials: T
authors.lastname: Beinert
authors.forename: C
authors.initials: C
authors.lastname: Langelotz
authors.forename: H G
authors.initials: HG
authors.lastname: Mergenthaler
authors.forename: K
authors.initials: K
authors.lastname: Possinger
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014740:Vidarabine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine