title: Prediction of progression or regression of type A aortic intramural hematoma by computed tomography.
abstract: BACKGROUND
  It has been reported that early surgery should be required for patients with type A aortic intramural hematoma (IMH) because it tends to develop classic aortic dissection or rupture. However, the anatomic features of type A IMH that develops dissection or rupture are unknown. The purpose of this study was to investigate the predictors of progression or regression of type A IMH by computed tomography (CT).
  
  
  RESULTS
  Twenty-two consecutive patients with type A IMH were studied by serial CT images. Aortic diameter and aortic wall thickness of the ascending aorta were estimated in CT images at 3 levels on admission and at follow-up (mean 37 days). We defined patients who showed increased maximum aortic wall thickness in the follow-up CT (n=9) or died of rupture (n=1) as the progression group (n=10). The other 12 patients, who all showed decreased maximum wall thickness, were categorized as the regression group. In the progression group, the maximum aortic diameter in the initial CT was significantly greater than that in the regression group (55+/-6 vs 47+/-3 mm, P=0.001). A Cox regression analysis revealed that the maximum aortic diameter was the strongest predictor for progression of type A IMH. We considered the optimal cutoff value to be 50 mm for the maximum aortic diameter to predict progression (positive predictive value 83%, negative predictive value 100%).
  
  
  CONCLUSIONS
  Maximum aortic diameter estimated by the initial CT images is predictive for progression of type A IMH.
authors.affiliation: Division of Cardiology, Kobe General Hospital, Kobe, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kaji
authors.forename: K
authors.initials: K
authors.lastname: Nishigami
authors.forename: T
authors.initials: T
authors.lastname: Akasaka
authors.forename: T
authors.initials: T
authors.lastname: Hozumi
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Kawamoto
authors.forename: H
authors.initials: H
authors.lastname: Okura
authors.forename: H
authors.initials: H
authors.lastname: Shono
authors.forename: Y
authors.initials: Y
authors.lastname: Horibata
authors.forename: T
authors.initials: T
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006406:Hematoma / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011859:Radiography; D014055:Tomography, Emission-Computed