Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
Zhang
Z
Z
Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Schuler
T
T
Zupancic
M
M
Wietgrefe
S
S
Staskus
K A
KA
Reimann
K A
KA
Reinhart
T A
TA
Rogan
M
M
Cavert
W
W
Miller
C J
CJ
Veazey
R S
RS
Notermans
D
D
Little
S
S
Danner
S A
SA
Richman
D D
DD
Havlir
D
D
Wong
J
J
Jordan
H L
HL
Schacker
T W
TW
Racz
P
P
Tenner-Racz
K
K
Letvin
N L
NL
Wolinsky
S
S
Haase
A T
AT
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology*; D002453:Cell Cycle; D002584:Cervix Uteri / Q000821:virology; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D008198:Lymph Nodes / Q000821:virology; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D012367:RNA, Viral / Q000032:analysis; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D013997:Time Factors; D014779:Virus Replication
D019380:Anti-HIV Agents; D012367:RNA, Viral