title: Glucose and methionine uptake and proliferative activity in meningiomas.
abstract: Despite similar benign histological appearances, proliferative activity of meningiomas varies tumor to tumor, and even region to region in a tumor. To predict proliferative potential before surgery, we compared regional uptake of 2-[18F]fluoro-2-deoxyglucose ([18F]FDG) and L-[methyl-11C]methionine ([11C]MET) with histological indices of tumor proliferative activity in 17 specimens from six patients with meningioma obtained by PET guided stereotactic biopsies. Uptake of [11C]MET, an index of protein synthesis rate, significantly correlated not only with the count of nucleolar organizer regions (NORs), a histological index of protein synthesis, but also with Ki-67 index, a histological index of proliferative activity. On the other hand, [18F]FDG uptake showed no significant correlation with Ki-67 index or clinical malignancy. These results suggest that [11C]MET-PET is a useful tool for predicting tumor proliferative potential in meningiomas.
authors.affiliation: Division of Neurological Surgery, Chiba Cancer Center, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwadate
authors.forename: H
authors.initials: H
authors.lastname: Namba
authors.forename: K
authors.initials: K
authors.lastname: Osato
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: A
authors.initials: A
authors.lastname: Yamaura
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008715:Methionine / Q000378:metabolism*; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine; D005947:Glucose