title: Ileal pouch salvage following failed ileal pouch- anal anastomosis.
abstract: Attempts have been made to salvage failed ileal pouch-anal anastomoses (IPAA) performed for ulcerative colitis or familial polyposis coli. These can be categorized as total reconstruction of the IPAA, partial transabdominal approach, and partial transperineal approach. The aims of our study were to determine the overall success of pouch salvage; to examine the demographics, indications, and outcomes for each approach; and to assess anorectal physiology and patient satisfaction in those with successful salvage operations. We reviewed data, including results of anorectal manometry, from 29 patients undergoing salvage procedures for failed IPAA. Seventeen salvage attempts were successful, 11 attempts failed, and one patient was lost to follow-up. Success rates were 100% in the total reconstruction group, 25% in the partial transabdominal group, and 55% in the transperineal group. In those undergoing total reconstruction of the IPAA (n = 9), functional outcome, as measured by incontinence, improved with 50% reporting incontinence preoperatively compared to 0% postoperatively (P = 0.055). Mean 24-hour stool frequency and nighttime stool frequency declined. All patients reported satisfaction with their outcomes. Sixty percent of patients who underwent ileal pouch salvage following IPAA have been successful in avoiding permanent ileostomy. These results suggest that a continued effort to salvage failed IPAA, including the use of total reconstruction, is a viable alternative to permanent ileostomy.
authors.affiliation: Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Saltzberg
authors.forename: C
authors.initials: C
authors.lastname: DiEdwardo
authors.forename: T E
authors.initials: TE
authors.lastname: Scott
authors.forename: W W
authors.initials: WW
authors.lastname: LaMorte
authors.forename: A F
authors.initials: AF
authors.lastname: Stucchi
authors.forename: J M
authors.initials: JM
authors.lastname: Becker
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery*; D000328:Adult; D003093:Colitis, Ulcerative / Q000601:surgery*; D005260:Female; D006801:Humans; D007081:Ileostomy; D008297:Male; D011183:Postoperative Complications / Q000601:surgery; D016737:Proctocolectomy, Restorative; D012086:Reoperation; D016879:Salvage Therapy