A comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients.
Anergy, or contrarily, Mitsuda-type responses towards 4 chemoautotrophic nocardioform antigens (CAN-Ags) and a control standard lepromin were tested in 73 LL, TT and borderline cases of leprosy. The antigens injected per patient varied from a maximum of 5 to a minimum of 2. Complete anergy to CAN-Ags was seen in 92/92 instances tested on 24 LL cases. The anergy was weakly modified or unmodified in 3 other LL cases which had been vaccinated before. Concurrent studies with the same antigens tested on 33 TT cases showed clear-cut, dose-dependent, Mitsuda-type late responses in 80/81 instances. The CAN bacteria, therefore, despite their origin from different unrelated leprous human, mouse footpad (MFP) and armadillo tissues, appeared to be identical with each other and also probably related to the leprosy bacillus, on the basis of these parameters.
Chakrabarty
A N
AN
Department of Medical Microbiology and Parasitology, University College of Medicine, Calcutta, India.
Dastidar
S G
SG
Chandra
A K
AK
Mukherjee
M
M
Chaudhuri
S K
SK
D000192:Actinomycetales / Q000276:immunology* / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000942:Antigens, Bacterial; D001135:Armadillos / Q000382:microbiology; D002648:Child; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D007916:Lepromin / Q000276:immunology*; D007918:Leprosy / Q000276:immunology* / Q000473:pathology; D015439:Leprosy, Borderline / Q000276:immunology / Q000473:pathology; D015440:Leprosy, Lepromatous / Q000276:immunology / Q000473:pathology; D015441:Leprosy, Tuberculoid / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000276:immunology
D000942:Antigens, Bacterial; D007916:Lepromin