[Mechanism of ovarian follicle selection for ovulation].
Mechanisms of ovarian follicles selection for ovulation remain incompletely deciphered. Studying mechanisms of transmission of hormonal stimulatory and inhibitory signals to follicular histion somatic cells may assist in progress in this area of knowledge. The present study was aimed to detect a-subunits of G proteins (common, stimulatory, inhibitory) involved in transmission of hormonal signals to intracellular effectors and phospholipase C, initiating phosphatidyl inositol mechanism of hormonal stimuli transmission, in cryostat sections of follicles using indirect immunolabeling. A-common subunit to labeling index of granulosa layer cells correlating with the phase of follicle development was identified. A direct relationship between phospholipase C activity in granulosa layer cells of antral follicles and their size was demonstrated as well. The perspective of research in this area and their significance for the development of the theory of follicle selection is discussed.
Volkova
O V
OV
Department of Histology and Embryology, Pediatric Faculty of Russian State Medical University, Moscow.
Borovaia
T G
TG
Didenko
L V
LV
D000818:Animals; D005260:Female; D019204:GTP-Binding Proteins / Q000737:chemistry; D007150:Immunohistochemistry; D006080:Ovarian Follicle / Q000502:physiology*; D010060:Ovulation / Q000502:physiology*; D010446:Peptide Fragments / Q000032:analysis; D051381:Rats; D015398:Signal Transduction / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D010446:Peptide Fragments; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins