[The effect of saltwort, Salsola collina, on the phospholipid composition of different sections of the rat brain after ethanol administration and its withdrawal].
The authors studied the effect of saltwort alcohol extract (Salsola CK, 200 mg/kg given daily per os for 7 days) on the content of phospholipid fractions in the cerebral hemisphere cortex and brain stem of rats in moderate alcohol intoxication and when the administration of ethanol was stopped (3rd and 7th day). Significant disorders of the phospholipid composition in these brain structures occurred in administration of ethanol and when it was stopped. Administration of CK had no neuroprotective effect on the phospholipid fractions of the cortex of the cerebral hemispheres and brain stem. The possible mechanisms of the discovered changes are discussed.
Selevich
M I
MI
Department of Psychiatrics, Grodno Medical Institute, Belorussian Republic Ministry of Public Health.
Lelevich
V V
VV
Razvadovskiĭ
Iu E
IuE
Doroshenko
E M
EM
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D018696:Neuroprotective Agents; D010743:Phospholipids; D010936:Plant Extracts; C401361:salsocollin; D000431:Ethanol