title: MRI of growth hormone-secreting pituitary adenomas: factors determining pretreatment hormone levels.
abstract: Preoperative serum growth hormone (GH) level is one of the most important determinants of outcome. Our aim was to assess MRI findings which may correlate with pretreatment GH levels in GH-secreting adenomas. We retrospectively studied 29 patients with acromegaly caused by a pituitary adenoma. Tumor size (height, width, thickness and volume), suprasellar extension, sphenoid or cavernous sinus invasion, signal intensity and contrast enhancement were studied. Linear regression analysis or Fisher's exact probability test was used for statistical analysis. Factors related to high GH levels were the maximum dimension of the tumour (r = 0.496, P < 0. 01), its volume (r = 0.439, P < 0.05), spenoid sinus invasion (P < 0. 01) and intracavernous carotid artery (encasement (P < 0.01). The other items were not related to serum GH levels. Since we believe surgery is the first choice of treatment and the cavernous sinus is difficult of access with a conventional surgical approach, preoperative assessment of invasion into the cavernous sinus is critical for predicting the surgical outcome. Low GH levels (5-50 ng/ml) were found with tumours medial to the intercarotid line and high levels (more than 101 ng/ml) with invasive tumours with carotid artery encasement. Variable GH levels were noted with tumours extending beyond the intercarotid line. Because functioning adenomas invading the cavernous sinus tend to have markedly high hormone levels, and only patients with carotid artery encasement showed markedly elevated GH levels, we believe carotid artery encasement a reliable MRI indicator of cavernous sinus invasion.
authors.affiliation: Department of Neurological Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuhoh-ku, Chiba-shi, Chiba, Japan 260-8670. cum138e@med.m.chiba-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: T
authors.initials: T
authors.lastname: Iuchi
authors.forename: S
authors.initials: S
authors.lastname: Isono
authors.forename: M
authors.initials: M
authors.lastname: Eda
authors.forename: A
authors.initials: A
authors.lastname: Yamaura
mesh_terms: D000172:Acromegaly / Q000209:etiology*; D000236:Adenoma / Q000150:complications / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000209:etiology; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019382:Human Growth Hormone