Regulation of the APC and the exit from mitosis.
The events of late mitosis, from sister-chromatid separation to cytokinesis, are governed by the anaphase-promoting complex (APC), a multisubunit assembly that triggers the ubiquitin-dependent proteloysis of key regulatory proteins. An intricate regulatory network governs APC activity and helps to ensure that late mitotic events are properly timed and coordinated.
Morgan
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Department of Physiology, University of California, San Francisco 94143-0444, USA. dmorgan@cgl.ucsf.edu
D000705:Anaphase / Q000502:physiology; D000818:Animals; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002455:Cell Division; D005656:Fungal Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000166:cytology / Q000235:genetics / Q000502:physiology
C577495:CDC20 protein, S cerevisiae; D064199:Cdc20 Proteins; D064200:Cdh1 Proteins; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins