[Effect of the serotoninergic substrate of the nucleus accumbens on the latent inhibition].
Latent inhibition (LI) is a reduction in the rate of acquisition of a conditioned response that results from repeated preexposure of an animal to a conditioned stimulus (CS). The present experiment was conducted to assess the effect of bilateral lesions of 5-OT terminals of the nucleus accumbens on LI in a conditioned passive avoidance response paradigm. The lesions were produced by administration of 5,7-DHT and resulted in disruption of LI. Sham-operated animals displayed the delay of conditioning (LI) in comparison with the non-preexposed controls. Disruption of the LI was prevented by systemic injection of haloperidol. Involvement of 5-HT substrate of the nucleus accumbens and its interaction with dopaminergic system in the process of the LI development is discussed.
Loskutova
L V
LV
Institute of Physiology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D004298:Dopamine