Association of ACE gene polymorphism with arterial stiffness in patients with type 2 diabetes.
OBJECTIVE
To assess the relationship between the insertion (I)/deletion (D) polymorphism of the ACE gene and arterial distensibility in patients with type 2 diabetes and healthy control subjects.


METHODS
Aortic and carotid arterial distensibility were evaluated by measuring aortic pulse-wave velocity (a-PWV) and carotid stiffness beta using an echo-tracking system in 137 patients with type 2 diabetes and 260 age-matched control subjects.


RESULTS
a-PWV and carotid stiffness beta were significantly higher in patients with type 2 diabetes than in age-matched control subjects (P < 0.05). Both stiffness beta and a-PWV were significantly higher in the patients with the II genotype than in those with the DD genotype (P < 0.001). In the control subjects, multiple regression analysis showed that age and decreased HDL cholesterol were independently associated with increased a-PWV (R2 = 0.244, P < 0.0001) and that age, systolic and diastolic blood pressure, and BMI were independently associated with increased carotid stiffness beta (R2 = 0.454, P < 0.0001). In the patients with type 2 diabetes, age, gene dose of the I allele, and systolic and diastolic blood pressure were independently associated with increased a-PWV (R2 = 0.545, P < 0.0001), and age, gene dose of the I allele, and systolic blood pressure were associated with increases in carotid stiffness beta (R2 = 0.314, P < 0.0001).


CONCLUSIONS
These results suggested that ACE polymorphism is associated with the impairment of aortic and carotid distensibility in patients with type 2 diabetes.
Taniwaki
H
H
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Kawagishi
T
T
Emoto
M
M
Shoji
T
T
Hosoi
M
M
Kogawa
K
K
Nishizawa
Y
Y
Morii
H
H
D000110:Acetylcholinesterase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001012:Aorta, Abdominal / Q000503:physiopathology; D001013:Aorta, Thoracic / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000503:physiopathology; D016022:Case-Control Studies; D003187:Compliance; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012598:Sclerosis / Q000235:genetics
D000110:Acetylcholinesterase