Binding of [(3)H]lysergic acid diethylamide to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults.
Possible age effects on binding of [(3)H]lysergic acid diethylamide ([(3)H]LSD) to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. Significant overall age effects were found both for the number of binding sites (B(max)) for [(3)H]LSD binding (p < 0.001), the affinity constant (K(d)) for [(3)H]LSD binding (p < 0.001), B(max) for [(3)H]paroxetine binding (p < 0.001) and K(d) for [(3)H] paroxetine binding (p = 0.006). In general, there was a decrease in B(max) with increasing age, which predominantly occurred between the ages 11-12 years and 16-17 years for the 5-HT(2A) receptor, and after 16-17 years of age for the serotonin uptake site. These developmental changes might have an impact on the effect of treatment with serotonergic drugs in children and adolescents. When the platelet serotonin variables investigated are employed in studies in children or adolescents, age matching or, alternatively, introduction of age control in the statistical analysis should be performed.
Sigurdh
J
J
Department of Child and Adolescent Psychiatry, Norrland University Hospital, Umeâ, Sweden.
Spigset
O
O
Allard
P
P
Mjörndal
T
T
Hägglöf
B
B
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism*; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000378:metabolism*; D008297:Male; D017374:Paroxetine / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000097:blood*; D012016:Reference Values; D018490:Serotonin Agents / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism*
D008238:Lysergic Acid Diethylamide; D017374:Paroxetine; D011985:Receptors, Serotonin; D018490:Serotonin Agents; D017367:Selective Serotonin Reuptake Inhibitors