title: A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions.
abstract: BACKGROUND
  The purpose of this study was to compare the effectiveness and safety of a chronic indwelling pleural catheter with doxycycline pleurodesis via tube thoracostomy in the treatment of patients with recurrent symptomatic malignant pleural effusions (MPE).
  
  
  METHODS
  In this multi-institutional study conducted between March 1994 and February 1997, 144 patients (61 men and 83 women) were randomized in a 2:1 distribution to either an indwelling pleural catheter or doxycycline pleurodesis. Patients receiving the indwelling catheter drained their effusions via vacuum bottles every other day or as needed for relief of dyspnea.
  
  
  RESULTS
  The median hospitalization time was 1.0 day for the catheter group and 6.5 days for the doxycycline group. The degree of symptomatic improvement in dyspnea and the quality of life was comparable in each group. Six of 28 patients who received doxycycline (21%) had a late recurrence of pleural effusion, whereas 12 of 91 patients who had an indwelling catheter (13%) had a late recurrence of their effusions or a blockage of their catheter after the initially successful treatment (P = 0.446). Of the 91 patients sent home with the pleural catheter, 42 (46%) achieved spontaneous pleurodesis at a median of 26.5 days.
  
  
  CONCLUSIONS
  A chronic indwelling pleural catheter is an effective treatment for the management of patients with symptomatic, recurrent, malignant pleural effusions. When compared with doxycycline pleurodesis via tube thoracostomy, the pleural catheter requires a shorter hospitalization and can be placed and managed on an outpatient basis.
authors.affiliation: Department of Thoracic Surgery, the University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Putnam
authors.forename: R W
authors.initials: RW
authors.lastname: Light
authors.forename: R M
authors.initials: RM
authors.lastname: Rodriguez
authors.forename: R
authors.initials: R
authors.lastname: Ponn
authors.forename: J
authors.initials: J
authors.lastname: Olak
authors.forename: J S
authors.initials: JS
authors.lastname: Pollak
authors.forename: R B
authors.initials: RB
authors.lastname: Lee
authors.forename: D K
authors.initials: DK
authors.lastname: Payne
authors.forename: G
authors.initials: G
authors.lastname: Graeber
authors.forename: K L
authors.initials: KL
authors.lastname: Kovitz
mesh_terms: D002408:Catheters, Indwelling; D003131:Combined Modality Therapy; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010994:Pleura; D018700:Pleurodesis; D011788:Quality of Life; D015996:Survival Rate; D017211:Treatment Failure
chemical_list: D004318:Doxycycline