Increased I-131 uptake in local recurrence and distant metastases after second treatment with retinoic acid.
We present a case of increased I-131 uptake in a patient with papillary thyroid carcinoma with local recurrence and distant metastases after a second treatment with retinoic acid as a sign of redifferentiation of the tumor cells. When fine-needle aspiration cytology before and after a second course of retinoic acid treatment were compared, signs of tumor cell redifferentiation were found. This was accompanied by biochemical reexpression of thyroid marker proteins.
Koerber
C
C
Clinic of Nuclear Medicine, University of Würzburg, Germany.
Schmutzler
C
C
Rendl
J
J
Koehrle
J
J
Griesser
H
H
Simon
D
D
Reiners
C
C
D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D015474:Isotretinoin / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*
D007457:Iodine Radioisotopes; D015474:Isotretinoin