The effects of trazodone on sleep disturbances induced by brofaromine.
The effects of trazodone on subjective and objective sleep parameters were compared to those of placebo in a double-blind design in seven patients who developed insomnia during treatment with the selective and reversible MAO-A inhibitor, brofaromine. Trazodone significantly increased deep sleep and altered the architecture of sleep in these patients. Subjectively, patients reported a better and deeper sleep. No negative interactions between brofaromine and trazodone were observed and side-effects were minimal. A low dose of trazodone may be a safe and effective agent in the treatment of MAO-I induced insomnia.
Haffmans
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Stichting RBC, location Monsterseweg, Monsterseweg 83, 2553 the Hague, the Netherlands.
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D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography; D005500:Follow-Up Studies; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D010880:Piperidines / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D012895:Sleep, REM / Q000187:drug effects*; D014196:Trazodone / Q000494:pharmacology* / Q000627:therapeutic use*; D014851:Wakefulness / Q000187:drug effects
D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone; C038213:brofaromine