title: Mesenteric infarction due to combined protein C deficiency and prothrombin 20210 defects.
abstract: The prothrombin gene mutation, 20210A, a guanine to adenine substitution at nucleotide position 20210, has recently been described as an additional risk factor for venous thromboembolic disease. We describe the case of a patient with combined heterozygous prothrombin 20210A mutation and type 1 protein C deficiency who presented with massive mesenteric venous infarction of his small bowel and survived following the use of protein C concentrate and extensive small bowel resection.
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mainwaring
authors.forename: M
authors.initials: M
authors.lastname: Makris
authors.forename: W E
authors.initials: WE
authors.lastname: Thomas
authors.forename: K K
authors.initials: KK
authors.lastname: Hampton
authors.forename: F E
authors.initials: FE
authors.lastname: Preston
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D008642:Mesenteric Veins; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020151:Protein C Deficiency / Q000150:complications*; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D011516:Prothrombin