title: Rapid cycling bipolar affective disorder in people with intellectual disability: a systematic review.
abstract: Rapid cycling bipolar affective disorder has attracted renewed interest in the general adult psychiatric literature, particularly as the response to lithium prophylaxis is poor in this subgroup of patients. The present paper describes a systematic Medline/Psyclit review of case studies and small series of patients with rapid cycling bipolar affective disorder in people with intellectual disability (ID). Rapid cycling bipolar affective disorder in people with ID may differ from its occurrence in the non-ID population in terms of a relative preponderance of males, an increased likelihood of rapid cycling onset in those with an early (prepubertal) onset of affective disorder and a different response to prophylactic drugs. The efficacy of treatment and prophylaxis of rapid cycling illnesses needs further investigation in the population with ID.
authors.affiliation: Child Development Centre, Poole Hospital Site, UK.
authors.forename: M
authors.initials: M
authors.lastname: Vanstraelen
authors.forename: S P
authors.initials: SP
authors.lastname: Tyrer
mesh_terms: D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D002220:Carbamazepine / Q000627:therapeutic use; D004314:Down Syndrome / Q000150:complications; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D008094:Lithium / Q000627:therapeutic use; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D018692:Antimanic Agents; D002220:Carbamazepine; D014635:Valproic Acid; D008094:Lithium