title: [Aseptic meningitis induced by high-dose gamma-globulin in an adult woman with antiphospholipid syndrome and chronic idiopathic thrombocytopenic purpura].
abstract: It is well known that the administration of high-dose gamma-globulin concentrate is effective in alleviating thrombocytopenia in patients with idiopathic thrombocytopenic purpura (ITP). However, treatment can sometimes induce aseptic meningitis. A 25-year-old Japanese woman with antiphospholipid syndrome and ITP was conditioned with high-dose gamma-globulin concentrate prior to splenectomy. Three days after the initial gamma-globulin course, she experienced severe headache, vomiting, and high-grade fever. Cerebrospinal fluid examination yielded a diagnosis of aseptic meningitis. The patient's clinical symptoms and abnormal cerebrospinal fluid findings disappeared immediately after the discontinuation of gamma-globulin therapy. Cases of aseptic meningitis induced by high-dose gamma-globulin therapy are uncommon in the literature, and most involve children. Moreover, to our knowledge, only 1 Japanese adult ITP case of gamma-globulin-induced aseptic meningitis has been reported to date. Aseptic meningitis may be one of the important adverse effects of the administration of high-dose gamma-globulin concentrate to pediatric as well as adult ITP patients.
authors.affiliation: Department of Internal Medicine (III), Kanazawa University School of Medicine.
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Mizutani
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Ontachi
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: E
authors.initials: E
authors.lastname: Morishita
authors.forename: H
authors.initials: H
authors.lastname: Asakura
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008582:Meningitis, Aseptic / Q000209:etiology*; D011300:Preoperative Care; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*; D013156:Splenectomy; D005719:gamma-Globulins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D005719:gamma-Globulins