[Liberation of drugs from impregnated wound dressings].
The present paper investigates drugs and polymers intended for the impregnation of textile carriers intended for use as wound covers. Their suitability was evaluated on the basis of the evaluation of the antimicrobial efficacy of a combination of trimetoprim and sulfadimidine with the local anaesthetics carbizocaine and lidocaine, and the immunomodulating substance fungal glucan. A greater inhibitory effect on the growth of microorganisms was shown by a combination of antimicrobial substances with carbizocaine. In the study of liberation of chlorohexidine from hydrophilic macromolecular dispersions its bond to glucan was confirmed. Dispersions of Natrosol proved to be more advantageous; chlorohexidine as well as local anaesthetics were released from them more rapidly than from methylcellulose gels. The dispersions under study are of a non-Newton character with pseudoplastic flow, glucan-containing gels are thixotropic.
Ducková
K
K
Katedra galenickej farmácie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Kucera
J
J
D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001419:Bacteria / Q000187:drug effects; D001458:Bandages
D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents