Neonatal end-stage renal failure associated with maternal ingestion of cyclo-oxygenase-type-1 selective inhibitor nimesulide as tocolytic.
Cyclo-oxygenase-type-2 (COX-2) enzyme is fundamental for nephrogenesis, upregulated on fetal membranes and myometrium at parturition. Fetal COX-2 inhibition, due to maternal nimesulide assumption, can be responsible for neonatal chronic renal failure.
Peruzzi
L
L
Gianoglio
B
B
Porcellini
M G
MG
Coppo
R
R
D000328:Adult; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013449:Sulfonamides / Q000009:adverse effects*
D016861:Cyclooxygenase Inhibitors; D013449:Sulfonamides; C012655:nimesulide