JC and BK virus sequences are not detectable in leukaemic samples from children with common acute lymphoblastic leukaemia.
Epidemiological evidence suggests that childhood leukaemia, and possibly common acute lymphoblastic leukaemia in particular, may have an infectious aetiology. Smith (1997 J Immunother 20: 89-100) recently suggested that the critical infectious event occurs during pregnancy, and identified the polyoma virus JC as a candidate agent. In the present study we investigated whether genomes from the JC virus, and closely related BK virus, could be detected in leukaemic cells. No positive results were obtained suggesting that JC virus is unlikely to play a direct role in leukaemogenesis.
MacKenzie
J
J
LRF Virus Centre, Department of Veterinary Pathology, University of Glasgow, UK.
Perry
J
J
Ford
A M
AM
Jarrett
R F
RF
Greaves
M
M
D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D007577:JC Virus / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000821:virology*
D004279:DNA, Viral