title: Treatment of amitriptyline poisoning with ovine antibody to tricyclic antidepressants.
abstract: We report clinical improvement with the use of an ovine antibody (Fab fragment) to tricyclic antidepressants for the treatment of toxic effects of amitriptyline on the central nervous system and heart in a 48-year-old man.
authors.forename: K
authors.initials: K
authors.lastname: Heard
authors.forename: G F
authors.initials: GF
authors.lastname: O'Malley
authors.forename: R C
authors.initials: RC
authors.lastname: Dart
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D014151:Anti-Anxiety Agents / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D007128:Immunoglobulin Fragments / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008140:Lorazepam / Q000506:poisoning; D008297:Male; D013406:Suicide, Attempted; D018879:Ventricular Premature Complexes / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D000639:Amitriptyline; D008140:Lorazepam