Analysis of GB virus C markers in families over three generations.
GB virus C (GBV-C) markers were analyzed in two to three generations in three families with documented vertical transmission of GBV-C. None of the maternal grandparents had GBV-C markers, whereas the male spouses had GBV-C envelope 2 antibodies. Evidence was found for intrafamilial transmission but not for GBV-C transmission over three generations.
Chen
M
M
Divisions of Clinical Virology and Basic Oral Science, Karolinska Institutet at Huddinge University Hospital, S-141 86 Huddinge, Sweden.
Fischler
B
B
Hultgren
C
C
Halasz
R
R
Nemeth
A
A
Sällberg
M
M
D000328:Adult; D000368:Aged; D015415:Biomarkers; D002648:Child; D005190:Family; D005260:Female; D018067:Flaviviridae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification*; D006525:Hepatitis, Viral, Human / Q000635:transmission* / Q000821:virology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012463:Saliva / Q000821:virology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D015415:Biomarkers; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C107619:glycoprotein E2, GB virus C