[Significance of selenium in regulation of inflammatory response by transcription factors in polytrauma patients. A clinical study].
The authors have investigated the relationship between selenium and transcription factors (NF-kappa B and AP-1) in the field of pathogenesis of polytrauma. Correlations between plasma selenium content and transcription factor binding activity have been found. The measured connecting capacitances of transcription factors have been associated with the severity of disease. To harden the results of this research a randomized double blind study with sodium selenite substitution is necessary next. This study will be to establish the therapy with sodium selenite in the treatment of polytrauma.
von Gagern
G
G
Klinik und Poliklinik für Viszeral-, Thorax- und Gefässchirurgie, Universitätsklinikum Carl Gustav Carus, TU Dresden.
Zimmermann
T
T
Albrecht
S
S
Bachmann
L
L
Zwipp
H
H
Saeger
H D
HD
D018806:APACHE; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000276:immunology* / Q000401:mortality; D016328:NF-kappa B / Q000235:genetics*; D012643:Selenium / Q000502:physiology*; D018038:Sodium Selenite / Q000008:administration & dosage*; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology* / Q000401:mortality; D018808:Transcription Factor AP-1 / Q000235:genetics*; D016896:Treatment Outcome
D016328:NF-kappa B; D018808:Transcription Factor AP-1; D012643:Selenium; D018038:Sodium Selenite