[Porphyria cutanea tarda after antineoplastic drugs].
Chronic hepatic porphyria is in some cases a paraneoplasia, in others part of the neoplastic disease. Sometimes it is, on the other hand manifested during antineoplastic treatment. Its development may be associated with this therapy. The presented case-history describes a female patient with breast cancer treated with antineoplastic agents, who developed a sporadic form of late cutaneous porphyria with a classical clinical and laboratory picture. The authors contemplate on the possible porphyrinogenic effect of antineoplastic agents, in particular cyclophosphamide and tamoxifen, which in the latter preparation was not described so far.
Malina
L
L
Dermatovenerologická klinika 3, LF UK, Praha.
Michalíková
H
H
Hussarová
L
L
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D003520:Cyclophosphamide / Q000009:adverse effects; D005260:Female; D006801:Humans; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects
D000970:Antineoplastic Agents; D013629:Tamoxifen; D003520:Cyclophosphamide