title: Variation in the spatial relationship between parvalbumin immunoreactive interneurones and pyramidal neurones in rat somatosensory cortex.
abstract: The morphology of pyramidal neurones was revealed by intracellular injection of Lucifer Yellow (LY) in fixed tangential cortical slices taken from rat primary somatosensory cortex. Slices were processed with a combination of antibodies to allow visualization of both the LY-injected neurones and parvalbumin immunoreactive (PV-ir) cell bodies, by confocal microscopy. Basal dendritic fields of pyramidal neurones in layer V were larger and more complex than those of layer III. Furthermore, the number of PV-ir cell bodies contained within the basal dendritic territories of pyramidal neurones in layer V was significantly greater than in layer III (mean +/- s.e.m., 36.3 +/- 3.0 and 20.9 +/- 1.6, respectively). These findings have functional implications both in terms of physiological characteristics, and inhibitory modulation of receptive field properties, of cortical neurones.
authors.affiliation: Vision, Touch and Hearing Research Centre, Department of Physiology and Pharmacology, The University of Queensland, Australia.
authors.forename: G N
authors.initials: GN
authors.lastname: Elston
authors.forename: J
authors.initials: J
authors.lastname: DeFelipe
authors.forename: J I
authors.initials: JI
authors.lastname: Arellano
authors.forename: M C
authors.initials: MC
authors.lastname: Gonzilez-Albo
authors.forename: M G
authors.initials: MG
authors.lastname: Rosa
mesh_terms: D000818:Animals; D048429:Cell Size; D003712:Dendrites / Q000648:ultrastructure; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism*; D018613:Microscopy, Confocal; D010320:Parvalbumins / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D010320:Parvalbumins