Enhanced efficacy of the combination of all-trans-retinoic acid and gamma-interferon in inhibiting proliferation of Tca8113 cells.
OBJECTIVE
To develop a more effective induced-differentiation or -apoptosis therapy for treating oral squamous cell carcinomas.


METHODS
The combination of all trans retinoic acid (ATRA) and interferon-gamma (IFN-gamma) was tested for its antiproliferative activity against human tongue squamous cell carcinoma cell line (Tca8113 cells) in vitro. Clonogenic assay, MTT assay, and microscopic cell analysis were performed in this experiment.


RESULTS
The results show that the combination of ATRA and IFN-gamma can produce synergistic antitumor effects, resulting from induction of apoptosis, on Tca8113 cells.


CONCLUSIONS
The combination of ATRA and IFN-gamma is a more effective induced-apoptosis therapy for treating oral squamous cell carcinoma.
Chen
W
W
Department of Oral and Maxillofacial Surgery, Shanghai Ninth Hospital, Shanghai Second Medical University (SSMU), P. R. China.
He
R
R
Zhang
Z
Z
Lin
G
G
Zhou
X
X
D017209:Apoptosis / Q000187:drug effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D014062:Tongue Neoplasms / Q000188:drug therapy*; D014212:Tretinoin / Q000494:pharmacology* / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
D014212:Tretinoin; D007371:Interferon-gamma