11-Deoxyfistularin-3, a new cytotoxic metabolite from the caribbean sponge Aplysina fistularis insularis.
11-Deoxyfistularin-3 (1), a new bromotyrosine derivative, was isolated among other known compounds such as fistularin-3 (2), aerothionin (3), and 11-oxoaerothionin (4) from the Caribbean sponge Aplysinafistularis (Aplysinellidae). The structure of 1 was determined by spectroscopic analysis and showed in vitro activity against the human breast carcinoma cell line MCF-7.
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Centro de Química Orgánica, Escuela de Química Facultad de Ciencias, Universidad Central de Venezuela, Apartado 47102, Caracas, Venezuela.
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
C400588:11-Deoxyfistularin-3; D000970:Antineoplastic Agents; D014443:Tyrosine