title: Nasopharyngeal teratoma and mosaic tetrasomy 1q detected at amniocentesis. A case report and review of the literature.
abstract: The occurrence of nasopharyngeal teratomas (NPT) is an infrequent event and prenatal detection of such tumors is even rarer. We present a case report and review of the literature (N = 78 cases), in which we describe the cytogenetic, DNA, and pathological findings of a fetus with a mature NPT which was detected prenatally by ultrasound investigation following complaints of severe polyhydramnios by the mother.
authors.affiliation: Department of Clinical Cytogenetics, Leiden University Medical Centre, The Netherlands.
authors.forename: G C
authors.initials: GC
authors.lastname: Beverstock
authors.forename: P
authors.initials: P
authors.lastname: Mollevanger
authors.forename: M
authors.initials: M
authors.lastname: Baaij
authors.forename: J
authors.initials: J
authors.lastname: Lind
authors.forename: L
authors.initials: L
authors.lastname: van Ieperen
authors.forename: M M
authors.initials: MM
authors.lastname: Bartelings
authors.forename: K
authors.initials: K
authors.lastname: Teunissen
authors.forename: H
authors.initials: H
authors.lastname: Brandenburg
authors.forename: D
authors.initials: D
authors.lastname: Van Opstal
authors.forename: F
authors.initials: F
authors.lastname: Los
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics*; D006831:Polyhydramnios; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013724:Teratoma / Q000000981:diagnostic imaging / Q000235:genetics*; D014463:Ultrasonography