title: Baroreflex sensitivity predicts the induction of ventricular arrhythmias by cesium chloride in rabbits.
abstract: Previous studies have shown that the autonomic nervous system plays an important role in the genesis of ventricular tachycardia (VT) in patients with long QT syndrome, and in cesium chloride (Cs)-induced VT in animals. The present study investigated whether baroreflex sensitivity predicts the induction of VT by Cs in the rabbit in vivo. Monophasic action potentials (MAPs) of the left ventricular endocardium were recorded simultaneously with the surface ECG in 27 rabbits. Rabbits were divided into 4 groups based on the Cs-induced ventricular arrhythmias: (1) no ventricular premature contractions (No-VPC group), (2) single or paired VPC (VPC group), (3) monomorphic VT (MVT group), and (4) polymorphic VT (PVT group). Baroreflex sensitivity was significantly lower in the MVT and PVT groups than in the No-VPC and VPC groups. The plasma norepinephrine concentration before Cs injection was significantly higher in the MVT group than in the other 3 groups, and the norepinephrine concentration after Cs injection was significantly higher in the MVT and PVT groups than in the No-VPC and VPC groups. Baroreflex sensitivity was negatively correlated with the norepinephrine concentration before Cs injection. These results suggest that autonomic nervous system dysfunction, as defined by reduced baroreflex sensitivity, and elevated plasma norepinephrine concentrations predict increased susceptibility to Cs-induced VT.
authors.affiliation: Department of Laboratory Medicine, Oita Medical University, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Ou
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Yonemochi
authors.forename: C
authors.initials: C
authors.lastname: Ri
authors.forename: S
authors.initials: S
authors.lastname: Ishida
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Saikawa
authors.forename: M
authors.initials: M
authors.lastname: Ito
mesh_terms: D000820:Animal Diseases / Q000503:physiopathology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology / Q000662:veterinary*; D017704:Baroreflex / Q000502:physiology*; D002586:Cesium; D002712:Chlorides; D004195:Disease Models, Animal; D004562:Electrocardiography; D008133:Long QT Syndrome / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011817:Rabbits / Q000502:physiology*; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000503:physiopathology; D018754:Ventricular Dysfunction / Q000139:chemically induced / Q000503:physiopathology / Q000662:veterinary
chemical_list: D002712:Chlorides; D002586:Cesium; C028019:cesium chloride; D009638:Norepinephrine