Non-Langerhans cell histiocytosis associated with lymphocyte-predominant Hodgkin's disease.
We report a 74-year-old man who presented with a rash on the trunk showing clinical and histological features of non-Langerhans cell histiocytosis. Two years after presentation he developed weight loss, lymphadenopathy and hepatosplenomegaly; a diagnosis of lymphocyte-predominant Hodgkin's disease was made on lymph node biopsy. The cutaneous signs and lymphoma responded to chemotherapy. Taken in conjunction with previously published reports of associations between cutaneous histiocytoses and haematological malignancies, we recommend close observation of patients in whom a diagnosis of non-Langerhans cell histiocytosis is made.
Ibbotson
S H
SH
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Sviland
L
L
Slater
D N
DN
Reynolds
N J
NJ
D000368:Aged; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male