[Experience with the therapy of acute finger ischemia by high-dose intra-arterial infusion of PGE1 through a surgically introduced catheter].
We present five patients with serious ischemia of the fingers caused by intra-arterial injection injury, trauma, rheumatoid arthritis, chronic myeloid leukemia with thrombocytosis and thoracic-outlet syndrome. The treatment consisted of thrombectomy and intra-arterial lysis if possible and intra-arterial infusion of 80 microg PGE1/24 h in combination with 25,000 U of heparin/24 h for 6-10 days. PGE1 and heparin were administered through a 3-F catheter introduced surgically into a forearm artery. In three cases a complete remission was possible, in the other two cases the therapy led to significant improvement. No side effects or complications were noticed.
Altstaedt
H O
HO
Klinik für Gefässchirurgie des Städtischen Krankenhauses Gütersloh.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D000792:Angiography; D002408:Catheters, Indwelling; D004359:Drug Therapy, Combination; D005260:Female; D005385:Fingers / Q000098:blood supply; D006225:Hand / Q000098:blood supply*; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000295:instrumentation*; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D006493:Heparin; D000527:Alprostadil