Comparison of an antiviral activity of recombinant consensus interferon with recombinant interferon-alpha-2b.
To avoid possible uncertainty in comparing biological activities of interferon samples from different sources where interferon concentrations were determined independently, we prepared chromatographically pure preparations of consensus interferon and interferon-alpha-2b (one of the two commercially available recombinant alpha interferons). We revealed that consensus interferon has a stronger antiviral activity than interferon-alpha-2b, although the effects of these two recombinant interferons on the cellular macromolecule synthesis are at similar levels.
Koyama
A H
AH
Department of Virology, School of Medicine, The University of Tokushima, Japan.
Arakawa
T
T
Adachi
A
A
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011994:Recombinant Proteins; D014316:Tritium; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000254:growth & development
D000998:Antiviral Agents; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D014316:Tritium; C050739:interferon alfacon-1; D004247:DNA