title: Therapy-related megakaryoblastic leukemia with pituitary involvement following treatment for non-Hodgkin's lymphoma.
abstract: A case of a 66-year-old Japanese man developed therapy-related megakaryoblastic leukemia with pituitary involvement after chemotherapy for non-Hodgkin's lymphoma. Alkylating agents had been administered for the treatment of non-Hodgkin's lymphoma and 6 years later, megakaryoblastic leukemia with myelofibrosis and myelodysplasia developed. The blast cells expressed CD41, and immature antigens also. These findings were compatible with therapy-related megakaryoblastic leukemia. An autopsy revealed blast-cell infiltration into multiple organs including the posterior pituitary lobe. Therapy-related megakaryoblastic leukemia is very rare, and pituitary involvement may be associated with immaturity of blast cells.
authors.affiliation: First Department of Internal Medicine, Nihon University School of Medicine, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: M
authors.initials: M
authors.lastname: Saiki
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Aikawa
authors.forename: I
authors.initials: I
authors.lastname: Tsuboi
authors.forename: U
authors.initials: U
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Horie
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000139:chemically induced*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D010902:Pituitary Gland / Q000473:pathology
chemical_list: D015703:Antigens, CD; D018906:Antineoplastic Agents, Alkylating