title: Surgery of the complete atrioventricular canal: relationship between age at operation, mitral regurgitation, size of the ventricular septum defect, additional malformations and early postoperative outcome.
abstract: The perioperative risk after repair of the complete atrioventricular canal is reported to be low provided there is a balanced relationship of both ventricles, and elevated pulmonary vascular resistance has been demonstrated to be reversible. However, some pre- and perioperative conditions may adversely affect early postoperative outcome. A consecutive series of 42 patients (mean age 8.5 months, 34/42, 81%, with trisomy 21) operated between 1994 and 1998 was analyzed prospectively for pre- and perioperative risk factors. Echocardiography alone was performed in 35 patients whereas cardiac catheterization was performed in 7 patients aged more than 18 months to confirm operability. Additional malformations were found in 20 patients. Early mortality was 2.3% (1/42), and postoperatively a low cardiac output was observed in 25 patients (59%); NO inhalation was used in 12 patients. Only the size of the ventricular septal defect (> than the diameter of the aortic annulus) could be identified as a predictor of adverse postoperative outcome in multivariate analysis. The presence of associated intracardiac malformations showed a trend to increased perioperative risk in multivariate analysis. Early results after repair of the complete atrioventricular canal are excellent. Survival, postoperative morbidity and normalization of pulmonary artery pressure can be related to the size of the ventricular septal defect. Continuous monitoring of the pulmonary artery pressure (with consequent NO application when indicated) is probably responsible for the low perioperative risk encountered in this series, despite the high incidence of postoperative pulmonary artery hypertension.
authors.affiliation: Clinic for Cardiovascular Surgery, University Hospital Berne, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Schaffer
authors.forename: P
authors.initials: P
authors.lastname: Berdat
authors.forename: B
authors.initials: B
authors.lastname: Stolle
authors.forename: J P
authors.initials: JP
authors.lastname: Pfammatter
authors.forename: F
authors.initials: F
authors.lastname: Stocker
authors.forename: T
authors.initials: T
authors.lastname: Carrel
mesh_terms: D000280:Administration, Inhalation; D000367:Age Factors; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D002303:Cardiac Output, Low / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications*; D006343:Heart Septal Defects / Q000473:pathology / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000473:pathology / Q000601:surgery; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D007223:Infant; D008168:Lung / Q000098:blood supply; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications*; D015999:Multivariate Analysis; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000502:physiology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide