Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs.
Some patients with dysmotility-like functional dyspepsia present impaired reservoir functions such as gastric adaptive relaxation. A traditional Chinese herbal medicine, Liu-Jun-Zi-Tang, has been identified as an effective drug against dyspeptic symptoms and is widely used for therapy in such patients. In this study, we examined the effects of this drug on the gastric adaptive relaxation in isolated guinea pig stomachs. The changes in intragastric volume and pressure were recorded in the presence of atropine and guanethidine. Gastric adaptive relaxation was induced by luminal distention. Liu-Jun-Zi-Tang (100 mg/ml) induced gastric adaptive relaxation at a lower intragastric pressure and increased the % volume of the gastric adaptive relaxation and the absolute intragastric volume. Metoclopramide (2 mg/ml), trimebutine (6 mg/ml) and cisapride (2 mg/ml) did not affect gastric adaptive relaxation. It was inhibited by means of the incubation of the stomach with NG-nitro-L-arginine (100 microM). Liu-Jun-Zi-Tang (100 mg/ml), but not gastroprokinetics overcame the effect of NG-nitro-L-arginine. These results suggested that Liu-Jun-Zi-Tang promoted gastric adaptive relaxation. This effect might, at least in part, contribute to the symptom relief in patients with functional dyspepsia.
Hayakawa
T
T
Central Research Laboratories, Tsumura & Co., Ibaraki, Japan. hayakawa_terumasa@mail.tsumura.co.jp
Arakawa
T
T
Kase
Y
Y
Akiyama
S
S
Ishige
A
A
Takeda
S
S
Sasaki
H
H
Uno
H
H
Fukuda
T
T
Higuchi
K
K
Kobayashi
K
K
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D020117:Cisapride / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005765:Gastrointestinal Agents / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D019335:Nitroarginine / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D014287:Trimebutine / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents; C084136:liu-jun-zi-tang; D019335:Nitroarginine; D001120:Arginine; D008787:Metoclopramide; D014287:Trimebutine; D020117:Cisapride