The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice.
The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. 5-HTP dose dependently increased serum leptin levels in mice. Pretreatment of the peripheral aromatic amino acid decarboxylase inhibitor carbidopa suppressed 5-HTP-induced hyperleptinemia. These results suggest that the secretion of leptin may be modified by serotonergic mechanisms.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, Kobe, Japan. j-yamada@kobepharma-u.ac.jp
Sugimoto
Y
Y
Ujikawa
M
M
D006916:5-Hydroxytryptophan / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006949:Hyperlipidemias / Q000139:chemically induced*; D020738:Leptin / Q000097:blood*; D008297:Male; D051379:Mice; D013997:Time Factors
D004791:Enzyme Inhibitors; D020738:Leptin; D006916:5-Hydroxytryptophan; D002262:Carboxy-Lyases