title: Unilateral angiolymphoid hyperplasia with eosinophilia involving the left arm and hand.
abstract: A case report of recurrent angiolymphoid hyperplasia with eosinophilia (ALHE) in an otherwise healthy 20-year-old female with manifestation of the disease limited to the left arm and hand is presented together with brief evaluation of the literature as well as the features distinguishing ALHE and Kimura's disease. Immunohistochemical investigations support the hypothesis that ALHE represents a reactive inflammatory lesion rather than a benign vascular neoplasm. A viral cause of ALHE (e.g., HHV8 or Epstein-Barr virus (EBV)) could not be demonstrated. The recurrent nature of the disease is shown by this case, which also demonstrates the need for frequent medical and surgical management.
authors.affiliation: Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Arnold
authors.forename: C C
authors.initials: CC
authors.lastname: Geilen
authors.forename: S E
authors.initials: SE
authors.lastname: Coupland
authors.forename: S
authors.initials: S
authors.lastname: Krengel
authors.forename: E
authors.initials: E
authors.lastname: Dippel
authors.forename: J
authors.initials: J
authors.lastname: Spröder
authors.forename: S
authors.initials: S
authors.lastname: Goerdt
authors.forename: C E
authors.initials: CE
authors.lastname: Orfanos
mesh_terms: D000328:Adult; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000378:metabolism / Q000473:pathology*; D001132:Arm / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001916:Brachial Artery / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005385:Fingers / Q000473:pathology; D006225:Hand / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D014408:Biomarkers, Tumor