Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine.
Cancer-screening tests for internal organs are severely constrained by low specificity or sensitivity, cost, and morbidity. We report a non-invasive immunofluorometric assay for detection of urothelial cancers based on ectopic expression of the DNA replication protein Mcm5.
Stoeber
K
K
Halsall
I
I
Freeman
A
A
Swinn
R
R
Doble
A
A
Morris
L
L
Coleman
N
N
Bullock
N
N
Laskey
R A
RA
Hales
C N
CN
Williams
G H
GH
D014408:Biomarkers, Tumor; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000652:urine*; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; C489423:MCM5 protein, human