Does senna extract promote growth of aberrant crypt foci and malignant tumors in rat colon?
Current evidence suggests that aberrant crypt foci (ACF) can be used to evaluate agents for their potential colon carcinogenic activity. The aim of the present study was to determine whether senna pod extract (SE) itself induces ACF and tumors in the rat colon or increases the development of ACF and tumors induced by azoxymethane (AOM). A daily administration of SE 10 mg/kg by mouth for 13-28 weeks produced a weak laxative effect but did not itself cause the appearance of ACF or tumors. The numbers of ACF and tumors induced by AOM were, however, increased by a dose of SE (100 mg/kg) able to induce chronic diarrhea over three months. These results suggest that SE does not cause the appearance of ACF or tumors in the rat colon nor does it have a promoting effect when given to rats at a dose that produces laxation (10 mg/kg), whereas a diarrhogenic dose (100 mg/kg) increases the appearance of tumors induced by AOM.
Mascolo
N
N
Department of Pharmaceutical Sciences, University of Salerno, Italy.
Mereto
E
E
Borrelli
F
F
Orsi
P
P
Sini
D
D
Izzo
A A
AA
Massa
B
B
Boggio
M
M
Capasso
F
F
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D001397:Azoxymethane; D002273:Carcinogens; D002400:Cathartics / Q000633:toxicity*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002273:Carcinogens; D002400:Cathartics; D000081226:Sennosides; D012676:Senna Extract; D001397:Azoxymethane