title: Short-term effects of marathon running in master runners: no evidence of myocardial injury.
abstract: The purpose of this investigation was to analyze the short-term effects of marathon running on serum levels of cardiac markers in a group of master runners (> 60 yrs). Ten marathoners (9 male and 1 female; 63+/-4 yrs) were enrolled in the study. All of them completed the Madrid Marathon (1998). Venous blood was drawn from each subject three times during the study (48 h before the race, immediately after the race, and 24 h post-competition) for the determination of the several biochemical markers, such as total creatine kinase catalytic activity (total CK), mass concentration of creatine kinase isoenzyme MB (CK-MB mass), and cardiac troponin I (Tnl-c). The most important finding was that in each sample (pre- or post-race) serum Tnl-c was below the commonly accepted level of 0.1 ng x m(-1) indicative of myocardial injury. Although further research is needed using more complete methodology, our results suggest that marathon running does not have an acute deleterious effect on the hearts of the elderly.
authors.affiliation: Departamento de Ciencias Morfológicas y Fisiología, Universidad Europea de Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lucía
authors.forename: M
authors.initials: M
authors.lastname: Morán
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Saborido
authors.forename: E
authors.initials: E
authors.lastname: Díaz
authors.forename: A
authors.initials: A
authors.lastname: Megías
authors.forename: J L
authors.initials: JL
authors.lastname: Chicharro
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000209:etiology* / Q000503:physiopathology; D010807:Physical Endurance / Q000502:physiology; D012420:Running / Q000502:physiology*; D014336:Troponin / Q000032:analysis
chemical_list: D015415:Biomarkers; D014336:Troponin