[Aminopeptidases in human leukemia cells].
Aminopeptidase activity in lymphoid cells of patients with various lymphoproliferative diseases was studied. The enzyme activity was detected in lysates of all leukemic B- and T-cells. The lymphoid cells contained aminopeptidases of at least two classes: metallo- and SH-dependent enzymes. The SH-dependent aminopeptidase with pH optimum 8.5-9.0 was revealed in lymphoid cells for the first time, and it seems to belong to a poorly studied aminopeptidase family.
Gureeva
T A
TA
Institute of Biomedical Chemistry, Moscow.
Golubeva
N V
NV
Lubkova
O N
ON
D000626:Aminopeptidases / Q000097:blood*; D001402:B-Lymphocytes / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007938:Leukemia / Q000097:blood / Q000201:enzymology*; D013601:T-Lymphocytes / Q000201:enzymology; D014407:Tumor Cells, Cultured
D000626:Aminopeptidases