6-Alkoxymethyl-3-hydroxy-4H-pyranones: potential ligands for cell-labelling with indium.
We have identified ligands for cell labelling with indium-111: 3-hydroxy-6-propoxymethyl-4H-pyran-4-one and 6-butoxymethyl-3-hydroxy-4H-pyran-4-one. The leucocyte labelling efficiencies of (111)In complexes of these ligands were higher and label stabilities were found to be similar compared with those obtained using (111)In-tropolonate. High labelling efficiencies of neutrophils and lymphocytes were achieved with (111)In complexes of pyranones. Tropolone was found to have a greater inhibitory effect on metalloenzymes and to cause greater impairment of platelet function than 3-hydroxy-6-propoxymethyl-4H-pyran-4-one. Thus 6-alkoxymethyl-3-hydroxy-4H-pyran-4-ones may have advantages over current ligands used in cell labelling with (111)In.
Ellis
B L
BL
Department of Nuclear Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.
Sampson
C B
CB
Abeysinghe
R D
RD
Porter
J B
JB
Hider
R C
RC
D000473:Alkanes / Q000138:chemical synthesis; D004912:Erythrocytes; D006801:Humans; D007205:Indium Radioisotopes; D007553:Isotope Labeling; D008024:Ligands; D008214:Lymphocytes; D009504:Neutrophils; D011714:Pyrans / Q000138:chemical synthesis; D014334:Tropolone
D000473:Alkanes; D007205:Indium Radioisotopes; D008024:Ligands; D011714:Pyrans; D014334:Tropolone