mRNA quantification of C-type natriuretic peptide in brain areas of rodents.
C-type natriuretic peptide (CNP) is regarded as an endothelium-derived vasodilator and might therefore have an important role in controlling vascular tone and remodeling. Because CNP also is expressed in the brain, it is considered to be a neurotransmitter. The present study compares expression levels of CNP mRNA in distinct areas of the mouse brain with the expression pattern in the rat brain. A distinct expression of CNP was found in all investigated areas with the exception of the mouse striatum. In both rodents, high CNP expression was detected in the tegmentum.
Stepan
H
H
Department of Obstetrics and Gynecology, University of Leipzig, Germany.
Leitner
E
E
Siems
W E
WE
Maul
B
B
Walther
T
T
D000818:Animals; D001921:Brain / Q000378:metabolism*; D015870:Gene Expression; D051379:Mice; D008810:Mice, Inbred C57BL; D020098:Natriuretic Peptide, C-Type / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger; D051381:Rats; D011921:Rats, Inbred WKY; D012377:Rodentia
D012333:RNA, Messenger; D020098:Natriuretic Peptide, C-Type