Taurine and its trophic effects in the retina.
The sulphur amino acid taurine possesses variable functions during development and regeneration of the central nervous system. The retina synthesize and uptake taurine, which is the amino acid present in the highest concentration in this tissue. Deficiency of taurine alters the structure and the function of the cerebral and cerebellar cortex, as well as the retina. Taurine increases outgrowth of postcrush goldfish retina in culture, partially by elevating calcium influx, and also by the modulation of protein phosphorylation. Its concentration increases in the retina after the lesion of the optic nerve, and the intraocular injection of it, between the crush and the explantation, stimulates the outgrowth of neurites. Taken together, although there are a great number of unresolved questions on the mechanisms of action of this amino acid as a trophic substance, the results support the role of taurine during regeneration of the optic nerve.
Lima
L
L
Laboratorio de Neuroquímica, Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas, Caracas. llima@cbb.ivic.ve
D000818:Animals; D006801:Humans; D009410:Nerve Degeneration; D009900:Optic Nerve / Q000502:physiology / Q000601:surgery; D012038:Regeneration; D012160:Retina / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D013654:Taurine / Q000172:deficiency / Q000494:pharmacology* / Q000502:physiology*
D013654:Taurine