Ion-selective electrode for the determination of trazodone in tablets.
A coated wire trazodone-selective electrode based on incorporation of trazodone-tetraphenylborate ion pair in a poly(vinylchloride) coating membrane was constructed. The influences of membrane composition, temperature, pH of the test solution, and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a trazodone concentration range from 1.41 x 10(-5) to 0.89 x 10(-2) M, at 25 degrees C, and was found to be very selective, precise, and usable within the pH range 2.4-9.0. The standard electrode potentials, E degree, were determined at 20, 25, 30, 35, 40 and 45 degrees C and used to calculate the isothermal temperature coefficient (dE degree/dT) of the electrode. Temperatures higher than 45 degrees C seriously affected the electrode performance. The electrode was successfully used for potentiometric determination of trazodone hydrochloride both in pure solutions and in pharmaceutical preparations.
Khalil
S
S
Department of Chemistry, Faculty of Science, Cairo University, Fayoum Branch, Egypt.
D018687:Antidepressive Agents, Second-Generation / Q000032:analysis*; D006801:Humans; D017736:Ion-Selective Electrodes; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis*; D013607:Tablets; D014196:Trazodone / Q000032:analysis*
D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors; D013607:Tablets; D014196:Trazodone