title: Attempting to maintain normoglycemia during cardiopulmonary bypass with insulin may initiate postoperative hypoglycemia.
abstract: We attempted to develop an insulin administration protocol that maintains normoglycemia in patients undergoing cardiac surgery and to study the effects of intraoperative blood glucose management on serum levels of creatine phosphokinase isoenzyme BB (CK-BB) and S-100 protein. Twenty nondiabetic patients were randomly allocated to receive either "tight control" of blood glucose with a standardized IV insulin infusion intraoperatively (Group TC) or "no control" of blood glucose intraoperatively (Group NC). Perioperative serum levels of glucose, CK-BB, and S-100 protein were determined in all patients. Group TC patients received 90.0 +/- 49.2 units of insulin, whereas Group NC patients received none. Despite insulin, both Group TC (P = 0.00026) and Group NC (P = 0.00003) experienced similar significant increases in blood glucose levels during hypothermic cardiopulmonary bypass. However, mean blood glucose level upon intensive care unit arrival was significantly decreased in Group TC, compared with Group NC (84.7 +/- 41.0 mg/dL, range 32-137 mg/dL vs 201.4 +/- 67.5 mg/dL, range 82-277 mg/dL, respectively; P = 0.0002). Forty percent of Group TC patients required treatment for postoperative hypoglycemia (blood glucose level <60 mg/dL). Substantial interindividual variability existed in regard to insulin resistance. The investigation was terminated after we realized that normoglycemia was unattainable with the study protocol and that postoperative hypoglycemia was unpredictable. All patients in both groups experienced similar significant increases in postoperative serum levels of CK-BB and S-100 protein. These results indicate that "tight control" of intraoperative blood glucose in nondiabetic patients undergoing cardiac surgery was unattainable with the study protocol and may initiate postoperative hypoglycemia.
  
  
  CONCLUSIONS
  The appropriate intraoperative management of hyperglycemia and whether it adversely affects neurologic outcome in patients after cardiac surgery remains controversial. This investigation reveals that attempting to maintain normoglycemia in this setting with insulin may initiate postoperative hypoglycemia.
authors.affiliation: Department of Anesthesiology, Loyola University Medical Center, Maywood, Illinois 60513, USA. MCHANEY@LUC.EDU
authors.forename: M A
authors.initials: MA
authors.lastname: Chaney
authors.forename: M P
authors.initials: MP
authors.lastname: Nikolov
authors.forename: B P
authors.initials: BP
authors.lastname: Blakeman
authors.forename: M
authors.initials: M
authors.lastname: Bakhos
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000628:therapy; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects; D007432:Intraoperative Period; D007527:Isoenzymes; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced* / Q000628:therapy; D011446:Prospective Studies; D009418:S100 Proteins / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007527:Isoenzymes; D009418:S100 Proteins; D003402:Creatine Kinase