title: Approaching the patient with chronic malabsorption syndrome.
abstract: The causes of chronic malabsorption may be categorized as decreased intestinal absorption, most commonly caused by celiac sprue; or maldigestion caused by pancreatic insufficiency. The initial step in the evaluation of these patients should include stool studies to confirm fat malabsorption. If fat malabsorption is confirmed, endoscopy with small-bowel biopsies and aspirates for bacterial culture usually follows. A normal endoscopic examination should lead to assessment of pancreatic function. In the setting of normal pancreatic function and the absence of bile acid deficiency, a barium radiograph of the small bowel should be made, looking for anatomical abnormalities. Celiac sprue is an intolerance to gluten caused by a combination of genetic, environmental, and immunologic factors. It classically causes malabsorption. However, it is likely that many patients who exhibit only minor manifestations of the disease go unrecognized and untreated. A presumed diagnosis of celiac sprue is confirmed after a clinical and endoscopic response to a gluten-free diet. Serological markers are available with high degrees of sensitivity and specificity, but duodenal biopsy remains the gold standard for diagnosis. A minority of patients are unresponsive to a gluten-free diet, and intestinal lymphoma should be suspected in these cases.
authors.affiliation: Department of Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Harewood
authors.forename: J A
authors.initials: JA
authors.lastname: Murray
mesh_terms: D000328:Adult; D001323:Autoantibodies; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000276:immunology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology*; D004386:Duodenum / Q000473:pathology; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000175:diagnosis* / Q000209:etiology
chemical_list: D001323:Autoantibodies