title: Securing meshed split-thickness skin grafts with 2-octylcyanoacrylate.
abstract: Meshed split-thickness skin grafts (STSGs) secured with 2-octylcyanoacrylate (2-OCA) were compared with meshed STSGs secured by suture and bolster (S&B). The 2 techniques were compared for graft survival, foreign-body giant cell response, inflammatory response, appearance, texture, and application time. Sixteen 2.5 x 2. 5 cm meshed STSGs were harvested from the dorsa of 2 pigs for a total of 32 grafts. On each pig 8 grafts were sprayed with 2-OCA, and the other 8 were secured with S&B. Evaluations were performed on postoperative days 14, 24, 48, and 56. Biopsy specimens were obtained on postoperative days 14 and 56. There were no significant differences in percent survival, foreign-body giant cell response, inflammatory response, and appearance between control and study grafts. The average time to apply the 2-OCA onto a graft was 3 seconds, compared with 8 minutes for S&B application. 2-OCA provides a quick and reliable means of securing meshed STSGs and would be especially useful in areas where it is difficult to use S&B, such as total maxillectomy defects.
authors.affiliation: University of Texas Health Science Center at San Antonio, 78284-7777, USA.
authors.forename: O A
authors.initials: OA
authors.lastname: Tamez
authors.forename: H S
authors.initials: HS
authors.lastname: McGuff
authors.forename: T J
authors.initials: TJ
authors.lastname: Prihoda
authors.forename: R A
authors.initials: RA
authors.lastname: Otto
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage*; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D006085:Graft Survival / Q000502:physiology; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation / Q000473:pathology; D013526:Surgical Mesh; D013536:Suture Techniques; D013552:Swine; D014014:Tissue Adhesives; D014945:Wound Healing / Q000502:physiology
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C119247:octylcyanoacrylate