title: Effect of theophylline on the warm-up phenomenon.
abstract: This study examined whether the adenosine receptor antagonist theophylline prevents the warm-up phenomenon in patients with stable angina undergoing serial exercise tests. Our findings offer evidence that adenosine does not play a role in the warm-up phenomenon, and indirectly suggest that the warm-up phenomenon does not represent ischemic preconditioning in humans.
authors.affiliation: Division of Cardiovascular Medicine, University of Florida, Shands at the University of Florida, Gainesville 32610-0277, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Kerensky
authors.forename: E
authors.initials: E
authors.lastname: Franco
authors.forename: J D
authors.initials: JD
authors.lastname: Schlaifer
authors.forename: C J
authors.initials: CJ
authors.lastname: Pepine
authors.forename: L
authors.initials: L
authors.lastname: Belardinelli
mesh_terms: D000241:Adenosine / Q000502:physiology*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology*; D017023:Coronary Angiography / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D008875:Middle Aged; D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline / Q000494:pharmacology*
chemical_list: D058915:Purinergic P1 Receptor Antagonists; D013806:Theophylline; D000241:Adenosine