title: Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.
abstract: The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt. Inactivation of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociously, during the third molt. LIN-42 most closely resembles the Period family of proteins from Drosophila and other organisms, proteins that function in another type of biological timing mechanism: the timing of circadian rhythms. Per mRNA levels oscillate with an approximately 24-hour periodicity. lin-42 mRNA levels also oscillate, but with a faster rhythm; the oscillation occurs relative to the approximately 6-hour molting cycles of postembryonic development.
authors.affiliation: Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, St. Paul, MN 55108, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jeon
authors.forename: H F
authors.initials: HF
authors.lastname: Gardner
authors.forename: E A
authors.initials: EA
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Deshler
authors.forename: A E
authors.initials: AE
authors.lastname: Rougvie
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000737:chemistry* / Q000235:genetics / Q000254:growth & development; D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D002454:Cell Differentiation; D002940:Circadian Rhythm; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D005091:Exons; D017238:Genes, Helminth; D015801:Helminth Proteins / Q000737:chemistry* / Q000235:genetics* / Q000502:physiology; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D018978:Molting; D009154:Mutation; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D056950:Period Circadian Proteins; D018510:RNA, Helminth / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid; D016415:Sequence Alignment; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics
chemical_list: D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D047908:Intracellular Signaling Peptides and Proteins; C400538:LIN-42 protein, C elegans; D009687:Nuclear Proteins; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; D018510:RNA, Helminth; D012333:RNA, Messenger; C400537:TIM-1 protein, C elegans; C509769:TIMELESS protein, human; C509770:Timeless protein, mouse; D014157:Transcription Factors; C096445:tim protein, Drosophila