title: In vivo femoropopliteal arterial wall compliance in subjects with and without lower limb vascular disease.
abstract: OBJECTIVE
  The purpose of this study was to further the development of a compliant vascular graft with a preliminary assessment of the elastic properties of the femoropopliteal artery in subjects with and without lower limb peripheral vascular disease.
  
  
  METHODS
  This prospective controlled study was set in a university department of surgery. Using an ultrasound scan wall tracking system with the simultaneous measurement of brachial blood pressure, measurements of femoropopliteal artery wall motion were undertaken in 11 patients with peripheral vascular disease (group 1), in 11 older control subjects who were matched for blood pressure, age, and sex (group 2), and in 12 younger control subjects (group 3). Diametrical compliance and stiffness index were determined for the common femoral artery, the proximal superficial femoral artery, the distal superficial femoral artery (DSFA), and the midgenicular popliteal artery.
  
  
  RESULTS
  All the arterial segments in group 1 showed a trend towards increased stiffness and less compliance than the group 2, age-matched control vessels, with significantly lower distensibility noted at the common femoral artery (mean compliance of 6.2% vs 14.1% mm Hg(-1) x 10(-2), respectively; P <.05) and the DSFA (mean compliance of 2.2% vs 1.9% mm Hg(-1) x 10(-2), respectively; P <.05). The popliteal artery segment in group 3 proved to be more compliant and less stiff than did the same vessel in group 2 (8.5% vs 4.7% mm Hg(-1) x 10(-2), respectively; P <.01). In all three study groups, the DSFA was consistently noted to be the least distensible vessel segment.
  
  
  CONCLUSIONS
  Lower limb peripheral vascular disease is associated with a reduction in femoropopliteal artery elasticity. Age alone appears to have a minimal effect on the compliance of the proximal half of the femoropopliteal segment. The elastic properties of the femoropopliteal vessel are subject to marked variation along its course. To minimize compliance mismatch, the degree of elasticity engineered into a vascular graft must reflect that observed in vivo.
authors.affiliation: Vascular Haemodynamic Laboratory, University Department of Surgery, Royal Free Hospital NHS Trust, London, United Kingdom.
authors.forename: N R
authors.initials: NR
authors.lastname: Tai
authors.forename: A
authors.initials: A
authors.lastname: Giudiceandrea
authors.forename: H J
authors.initials: HJ
authors.lastname: Salacinski
authors.forename: A M
authors.initials: AM
authors.lastname: Seifalian
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
mesh_terms: D000328:Adult; D000368:Aged; D001807:Blood Vessel Prosthesis; D016022:Case-Control Studies; D004548:Elasticity; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D016491:Peripheral Vascular Diseases / Q000503:physiopathology* / Q000601:surgery; D011150:Popliteal Artery / Q000000981:diagnostic imaging / Q000502:physiology*; D011446:Prospective Studies; D011474:Prosthesis Design; D014463:Ultrasonography; D014655:Vascular Resistance