[Coronary angiography and change in antioxidative status].
METHODS
In a prospective study in 53 patients with stable angina pectoris symptoms the antioxidant status (glutathione peroxidase, glutathione, superoxid dismutase, malondialdehyde and selenium in serum and whole blood) was determined before and 4 to 6 hours after coronary angiography. According to the results of the coronary angiography the patients were classified in a group with "severe" (n = 16) and another with "moderate" coronary alterations.


RESULTS
In both groups there was a significant reduction of selenium in serum and whole blood. The enzymes glutathione peroxidase and superoxide dismutase as well as glutathione and malondialdehyde changed only slightly.


CONCLUSIONS
These results can be the cause of an increase of the formation of free radicals during coronary reperfusion (PTCA, implantation of stents in the group with "severe" coronary alterations) but could also be seen as a sign of formation of radicals by the method itself (in patients with "moderate" coronary alterations). Further investigations are indicated. Furthermore the amelioration of the antioxidant status of the organism by scavenger substances (vitamins A, B, C and selenium) should be discussed.
Thiele
R
R
Klinik für Innere Medizin III, Friedrich-Schiller-Universität Jena.
Winnefeld
K
K
Lotze
U
U
Fischer
H J
HJ
Haas
J
J
Pfeifer
R
R
Thiele
A
A
Schubert
K
K
Madzgalla
I
I
D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000201:enzymology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000201:enzymology; D005260:Female; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D011446:Prospective Studies; D012643:Selenium / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D012643:Selenium