Cushing's disease in a 7-month-old girl due to a tumor producing adrenocorticotropic hormone and thyreotropin-secreting hormone.
We present the case of a 7-month-old baby with Cushing's disease due to an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma combined with cells producing thyreotropin-secreting hormone (TSH). In MRI scans, a contrast-enhancing lesion was seen inside the pituitary fossa, and it extended into the suprasellar region. On the assumption of a pituitary adenoma, surgery was performed. Corresponding with biochemical findings, histopathological evaluation revealed an ACTH- and TSH-producing tumor. Genetic analysis did not demonstrate an alteration at codon 201 (Arg) and 227 (Glu). To our knowledge, this is the first case described in a child of this age.
List
J V
JV
Department of Neurosurgery, Technical University, University Hospital Carl Gustav Carus, Dresden, Germany. list@rcs.urz.tu-dresden.de
Sobottka
S
S
Huebner
A
A
Bonk
C
C
Koy
J
J
Pinzer
T
T
Schackert
G
G
D000236:Adenoma / Q000097:blood / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis* / Q000097:blood; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D013972:Thyrotropin / Q000096:biosynthesis*
D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D019204:GTP-Binding Proteins