title: [Systemic reaction induced my minocycline treatment: a report of four patients and a review of the literature].
abstract: We report four cases of the side effects of minocycline seen during the last two years in our department. There was one case of drug-related lupus and three cases of hypersensitivity reactions, including one eosinophilic pneumopathy with pericarditis, one nephropathy and one severe, pseudo-infectious episode of high fever, rash, lympadenopathy, hepatitis and eosinophilia. Minocycline is a tetracycline agent widely used for acne therapy in France and all over the world. During the last few years, there has been an increasing number of reports concerning systemic adverse reactions to minocycline, with on the one hand auto-immune disorders (lupus, autoimmune hepatitis, vascularitis with ANCA), occurring after a prolonged course of therapy and reported recently in the last few years, and on the other hand, hypersensitivity reactions (eosinophilic pneumopathies, hepatitis, nephropathies, myocarditis, serum sickness or pseudo-infectious reactions), occurring precociously in the course of therapy, and potentially severe. Although these side effects are uncommon in the context of the high number of patients who have been prescribed the drug, the first-line antibiotic therapy in acne must probably be reconsidered.
authors.affiliation: Service de médecine interne, Hôpital Foch, Suresnes, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Piette
authors.forename: J
authors.initials: J
authors.lastname: Ramanoelina
authors.forename: P
authors.initials: P
authors.lastname: Gepner
authors.forename: C
authors.initials: C
authors.lastname: Larroche
authors.forename: O
authors.initials: O
authors.lastname: Blétry
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology; D004802:Eosinophilia / Q000139:chemically induced; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D008171:Lung Diseases / Q000139:chemically induced; D008177:Lupus Vulgaris / Q000139:chemically induced*; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline