Xylene-induced effects on brain neurotransmitters, behavior and fos protein in rats.
Male Sprague-Dawley rats administered xylene intraperitoneally on alternate days at a dose of 125 or 250 mg/kg for 30 days exhibited no marked changes in locomotor activity, learning and memory capacity. However in rats given xylene on alternate day at a dose of 500 mg/kg for 30 days, a significant decrease in locomotor activity, deficits in learning ability and memory loss were detected. These xylene-induced behavioral changes were associated with a decrease in beta-endorphin and leuenkaphlin concentrations in the pons-medulla. On the contrary, xylene at a dose of 500 mg/kg increased the beta-endorphin level in caudate and c-fos expression in hippocampus. These data suggest that the xylene-induced behavioral alterations might be associated with the expression of Fos protein in the hippocampus.
Wang
X L
XL
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China. xiulingwang@263.net
Jin
X P
XP
Fu
H
H
Chen
Z Q
ZQ
Da
C D
CD
Huang
X F
XF
Ding
B Q
BQ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007263:Infusions, Parenteral; D007858:Learning / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014992:Xylenes / Q000009:adverse effects*
D018377:Neurotransmitter Agents; D016760:Proto-Oncogene Proteins c-fos; D014992:Xylenes