Complex inheritance and localizing disease genes.
Most methods for localizing genes underlying complex traits work under the implicit or explicit assumption of a single disease gene with the possible exception of heterogeneity, that is, different disease genes in different families. We discuss current single-locus and multi-locus methods. Novel approaches are proposed that take into account all marker loci over the genome. A simple example is given for an unconventional statistic, i.e. the mean of allele sharing over all markers on a chromosome.
Hoh
J J
JJ
Division of Biostatistics, Columbia University, Rockefeller University, New York, NY 10021-6399, USA.
Ott
J
J
D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008432:Mathematical Computing