title: The predictive power of endocrine tests for the diagnosis of polycystic ovaries in women with oligoamenorrhea.
abstract: Various hormonal parameters and the best logistic regression model to predict disease probability were evaluated in women with polycystic ovary syndrome (PCOS). Concentrations of LH, FSH, LH/FSH ratio, testosterone, free testosterone, SHBG and insulin in serum were recorded in 32 women with PCOS and in 25 controls. A model including LH/FSH ratio, insulin and testosterone measurements yielded the best goodness of fit for classification of women with and without PCOS in the logistic regression analysis. Only LH/FSH ratio and insulin were retained as significant variables. The diagnostic characteristics of LH/FSH ratio and insulin for PCOS when compared by receiver-operator characteristic analysis were found to be equally effective. By combining these two variables a higher area under curve was obtained. LH/FSH ratio, insulin or the combination of these two can predict the disease probability in women with PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University Medical Faculty Hospital, Ankara, Turkey. nilgunturhan@hotmail.com
authors.forename: N O
authors.initials: NO
authors.lastname: Turhan
authors.forename: M F
authors.initials: MF
authors.lastname: Toppare
authors.forename: N C
authors.initials: NC
authors.lastname: Seçkin
authors.forename: G
authors.initials: G
authors.lastname: Dilmen
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D009839:Oligomenorrhea / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood
chemical_list: D006728:Hormones; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone