title: Structural changes and the storage of long-term memory in Aplysia.
abstract: Long-term memory for sensitization of the gill-withdrawal reflex in Aplysia is associated with the growth of new synaptic connections between sensory and motor neurons. The duration of this structural change parallels the behavioral retention of the memory. Such changes can be reconstituted in dissociated cell culture by repeated presentations of the modulatory neurotransmitter serotonin (5HT) and are associated with an activity-dependent downregulation of NCAM-related cell adhesion molecules thought to contribute to cell recognition and axonal outgrowth during development. Thus, aspects of the mechanisms utilized for learning-related synaptic growth initiated by experience in the adult may eventually be understood in the context of the molecular logic that shapes synaptic circuitry during the later stages of neuronal development.
authors.affiliation: Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and New York State Psychiatric Institute, New York, NY 10032, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Bailey
mesh_terms: D000818:Animals; D001048:Aplysia / Q000166:cytology / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D008568:Memory; D012018:Reflex; D013569:Synapses / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules