title: Human and mouse SYBL1 gene structure and expression.
abstract: SYBL1 is a gene in the 320kb human pseudo-autosomal region at the terminus of Xq and Yq. In contrast to other pseudoautosomal genes, SYBL1 is inactivated on one X in every female cell, and is also inactive on the Y of male cells. Hypermethylation of the CpG island associated with the human gene is involved in this phenomenon. In an attempt to further examine its regulation, the genomic organization of the X-linked mouse Sybl1 homolog was analyzed and compared with the human gene. Human and mouse show the same exon number, exon-intron junctions and a highly conserved basal promoter. The structural and functional conservation of basal regulatory regions suggests that inactivation is imposed by similar auxiliary epistatic regulatory mechanism.
authors.affiliation: International Institute of Genetics and Biophysics, CNR, 80125, Naples, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Matarazzo
authors.forename: M
authors.initials: M
authors.lastname: Cuccurese
authors.forename: M
authors.initials: M
authors.lastname: Strazzullo
authors.forename: M
authors.initials: M
authors.lastname: Vacca
authors.forename: A
authors.initials: A
authors.lastname: Curci
authors.forename: M G
authors.initials: MG
authors.lastname: Miano
authors.forename: M
authors.initials: M
authors.lastname: Cocchia
authors.forename: G
authors.initials: G
authors.lastname: Mercadante
authors.forename: A
authors.initials: A
authors.lastname: Torino
authors.forename: M
authors.initials: M
authors.lastname: D'Urso
authors.forename: A
authors.initials: A
authors.lastname: Ciccodicola
authors.forename: M
authors.initials: M
authors.lastname: D'Esposito
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D015152:Blotting, Northern; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005091:Exons; D015870:Gene Expression; D018507:Gene Expression Regulation, Developmental; D005796:Genes / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D007438:Introns; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D050683:R-SNARE Proteins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution; D014158:Transcription, Genetic
chemical_list: D008565:Membrane Proteins; D050683:R-SNARE Proteins; D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; C496927:Sybl1 protein, mouse; C121241:VAMP7 protein, human; D004247:DNA; D015500:Chloramphenicol O-Acetyltransferase