title: Bacterial two-component signalling as a therapeutic target in drug design. Inhibition of NRII by the diphenolic methanes (bisphenols).
authors.affiliation: Chemistry Department, Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Domagala
authors.forename: D
authors.initials: D
authors.lastname: Alessi
authors.forename: M
authors.initials: M
authors.lastname: Cummings
authors.forename: S
authors.initials: S
authors.lastname: Gracheck
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: M
authors.initials: M
authors.lastname: Huband
authors.forename: G
authors.initials: G
authors.lastname: Johnson
authors.forename: E
authors.initials: E
authors.lastname: Olson
authors.forename: M
authors.initials: M
authors.lastname: Shapiro
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: R
authors.initials: R
authors.lastname: Van Bogelen
authors.forename: D
authors.initials: D
authors.lastname: Vo
authors.forename: S
authors.initials: S
authors.lastname: Wold
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D000071677:Histidine Kinase; D006801:Humans; D015394:Molecular Structure; D051922:PII Nitrogen Regulatory Proteins; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D051922:PII Nitrogen Regulatory Proteins; D010636:Phenols; D047428:Protein Kinase Inhibitors; C404143:PIID regulatory protein, Bacteria; D011494:Protein Kinases; D000071677:Histidine Kinase