Effect of calcium channel blockers on cerebral ischemia-induced hyperactivity in Mongolian gerbils.
When both common carotid arteries of Mongolian gerbils were occluded for 5 min to produce ischemic insult, locomotor activity was increased the following day. The effect of calcium channel blockers on this ischemia-induced hyperactivity was investigated. Nimodipine, at doses of 5, 10, and 20 mg/kg, dose dependently and significantly decreased ischemia-induced hyperactivity. Nicardipine significantly decreased ischemia-induced hyperactivity and doses of 10 and 20 mg/kg. Nifedipine and flunaridine also significantly decreased ischemia-induced hyperactivity at doses of 20 mg/kg. Verapamil had no effect on ischemia-induced hyperactivity at a dose of 20 mg/kg. These findings suggest that ischemia-induced hyperactivity is related to calcium channels. These relationship between calcium channels and dopaminergic function is discussed.
Araki
H
H
Hospital Pharmacy Department, Okayama University Medical School, Japan. haraki@hospital.okayama-u.ac.jp
Hino
N
N
Karasawa
Y
Y
Kawasaki
H
H
Gomita
Y
Y
D000818:Animals; D002545:Brain Ischemia / Q000523:psychology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D017536:Carotid Artery, Common / Q000502:physiology; D005849:Gerbillinae; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects; D006948:Hyperkinesis / Q000523:psychology*; D008297:Male; D009043:Motor Activity / Q000502:physiology
D002121:Calcium Channel Blockers