title: Hymenoptera venom allergy: time course of specific IgE concentrations during the first weeks after a sting.
abstract: Detection of IgE antibodies specific to honeybee or Vespula venoms is an important criterium firstly for the diagnosis of sensitization and secondly for the indication for a specific immunotherapy. Some authors recommend to postpone blood analysis after an insect sting for a certain time because circulating IgE antibodies might be consumed by the allergic reaction, which would result in a false-negative test outcome. We investigated IgE concentrations during the first weeks after an insect sting in 31 patients with an unequivocal history of an anaphylactic reaction after a honeybee (n = 13) or Vespula (n = 18) sting. Blood samples for analysis of specific IgE concentrations (CAP system, Pharmacia Diagnostics, Sweden) were collected within 2 weeks and 5+/-2 weeks after the insect sting. 12/13 patients with honeybee venom and 14/18 patients with Vespula venom sensitization had CAP classes 1 or higher within the first 2 weeks. Those 5 patients with CAP class 0 within the first 2 weeks had detectable IgE concentrations a few weeks later. We conclude that testing for specific IgE to hymenoptera venoms is in most cases useful even during the first 2 weeks after the hymenoptera sting. This allows early decisions on further diagnostic procedures and the therapeutic way to choose. Patients with no detectable IgE should, however, be retested after a few weeks.
authors.affiliation: Department of Dermatology, Division of Environmental Dermatology and Venereology, University of Graz, Austria. verena-rieger@netway.at
authors.forename: V
authors.initials: V
authors.lastname: Rieger-Ziegler
authors.forename: E
authors.initials: E
authors.lastname: Rieger
authors.forename: B
authors.initials: B
authors.lastname: Kränke
authors.forename: W
authors.initials: W
authors.lastname: Aberer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000918:Antibody Specificity; D001180:Arthropod Venoms / Q000276:immunology*; D002648:Child; D005260:Female; D006801:Humans; D006927:Hymenoptera; D006967:Hypersensitivity / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007299:Insect Bites and Stings / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001180:Arthropod Venoms; C026408:anti-IgE antibodies; D007073:Immunoglobulin E