An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase.
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
Hanessian
S
Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, QC, H3C 3J7 (Canada).
Lu
PP
Sancéau
JY
Chemla
P
Gohda
K
Fonne-Pfister
R
Prade
L
Cowan-Jacob
SW