Design, synthesis and antimuscarinic activity of some imidazolium derivatives.
A series of imidazolium salt derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. On the basis of measurements of the antimuscarinic activity and subtype-selectivity for M2 and M3 muscarinic receptors, the structure-activity relationships of these compounds are discussed.
Miyachi
H
H
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan.
Kiyota
H
H
Segawa
M
M
D015195:Drug Design; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018727:Muscarinic Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000145:classification / Q000187:drug effects; D013329:Structure-Activity Relationship
D007093:Imidazoles; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic