Storage of blood components.
Recent studies have shown that a restrictive transfusion policy results in lower mortality in patients undergoing surgery. The negative effects of red cell transfusion are associated with the presence of contaminating leukocytes, leukocyte products, and probably also with effects of nonviable and poorly functioning red cells. By relatively simple means it is possible to improve the quality of red cells in these respects. The removal of leukocytes from platelet concentrates (PCs) is even more important because of high immunogenicity and capacity to produce cytokines under the storage conditions applied. Prestorage leukocyte removal has clear advantages. Bacterial contamination of PCs is common, but fatal bacterial complications are rare because most contaminating microorganisms grow slowly and do not produce toxins, which are frequent causes of death. Suitable methods for routine bacterial culture of PCs are available and used in some countries.
Högman
C F
CF
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
D001793:Blood Preservation; D001803:Blood Transfusion; D006801:Humans