Fibrin sealant in preclinical and clinical studies.
Fibrin sealant, now commercially available in the United States, is a virally inactivated preparation of highly purified human fibrinogen and human thrombin that includes aprotinin to reduce fibrinolysis. Although the product is relatively expensive, cost can be justified when the sealant is used to produce localized hemostasis in surgery in which bleeding cannot be controlled by sutures. Fibrin sealant can also be justified as an alternative to factor concentrates in patients with coagulopathies who have a localized site of bleeding. Newer formulations of fibrinogen and thrombin in a freeze-dried form applied as a bandage may be useful in immediate, on-site treatment of trauma victims in either a civilian or military setting.
Jackson
M R
MR
Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, USA. mjackson@flash.net
Alving
B M
BM
D000818:Animals; D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans
D015718:Fibrin Tissue Adhesive; D006490:Hemostatics