Progressive atrophy of the frontal lobes in first-episode schizophrenia: interaction with clinical course and neuroleptic treatment.
OBJECTIVE
This prospective study examined the interaction of clinical course of disease and brain structure with time in schizophrenic patients.


METHODS
A total of 21 first-episode schizophrenic patients, 10 patients with other psychiatric disorders and a control group of 9 healthy volunteers had CT at first admission and at reinvestigation 5 years later.


RESULTS
At first admission all of the patients had enlarged cortical fissures and sulci compared to controls, and the duration of untreated psychosis was significantly correlated with sulcal enlargement. At reinvestigation, frontal and central brain atrophy had progressed in schizophrenic patients.


CONCLUSIONS
The study indicated that ongoing psychosis and lifetime dose of classical antipsychotics were the main candidates accounting for the finding of progressively disturbed brain structure during the first 5 years of schizophrenia.
Madsen
A L
AL
Department of Psychiatry E, Bispebjerg Hospital, Copenhagen, Denmark.
Karle
A
A
Rubin
P
P
Cortsen
M
M
Andersen
H S
HS
Hemmingsen
R
R
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001284:Atrophy / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
D014150:Antipsychotic Agents