title: Dementia with leukoaraiosis: clinical differentiation by temporoparietal hypometabolism on (18)FDG-PET imaging.
abstract: Patients with dementia and leukoaraiosis may have either Alzheimer's disease (AD) with cerebrovascular changes or a form of vascular dementia (VaD). The presence or absence of the characteristic AD pattern of bilateral temporoparietal hypometabolism on (18)FDG-PET was used to differentiate 30 patients with progressive dementia and severe leukoaraiosis. Compared to 18 patients with the typical AD pattern (group I), the remaining 12 (group II) had better recognition memory, and greater difficulty with sustained attention and serial reversals. Better recognition memory, confluent periventricular leukoaraiosis, and poorer sustained attention distinguished all group II patients from group I. Dementia patients with severe leukoaraiosis and bilateral temporoparietal hypometabolism may have predominant AD; those who lack this pattern and have confluent leukoaraiosis may have a greater contribution from VaD. Copyrightz1999S.KargerAG,Basel
authors.affiliation: Psychiatry, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, Los Angeles, CA 90073, USA. MMendez@UCLA.edu
authors.forename: M F
authors.initials: MF
authors.lastname: Mendez
authors.forename: W
authors.initials: W
authors.lastname: Ottowitz
authors.forename: C V
authors.initials: CV
authors.lastname: Brown
authors.forename: J L
authors.initials: JL
authors.lastname: Cummings
authors.forename: K M
authors.initials: KM
authors.lastname: Perryman
authors.forename: M A
authors.initials: MA
authors.lastname: Mandelkern
mesh_terms: D000368:Aged; D002561:Cerebrovascular Disorders / Q000150:complications / Q000453:epidemiology; D003704:Dementia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D011569:Psychiatric Status Rating Scales; D019275:Radiopharmaceuticals; D012307:Risk Factors; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18