title: Transmissibility and persistence of oral polio vaccine viruses: implications for the global poliomyelitis eradication initiative.
abstract: The global poliomyelitis eradication initiative has been a tremendous success, with current evidence suggesting that wild poliovirus will cease to circulate anywhere in the world soon after the year 2000. As the goal of wild poliovirus eradication is approached, concern has been raised about the potential for persistent transmission of oral polio vaccine (OPV) viruses, as these viruses are known to revert toward wild-type neurovirulence. This paper has been extracted from a document prepared for the World Health Organization on the implications of OPV transmissibility for the strategy of stopping OPV vaccination after global eradication of wild polioviruses. The authors review the empirical evidence on OPV transmissibility available from household and community transmission studies and from mass-vaccination experiences. They then consider theoretical measures of transmissibility and persistence for wild and OPV viruses (secondary attack rate, basic reproduction number, and critical populations' size), to assess whether transmissibility of OPV viruses is sufficient to allow persistence of these viruses after cessation of vaccination. The findings indicate that OPV viruses could persist under various plausible circumstances, and that this potential should be a major consideration when planning the cessation of OPV vaccination.
authors.affiliation: London School of Hygiene and Tropical Medicine, United Kingdom.
authors.forename: P E
authors.initials: PE
authors.lastname: Fine
authors.forename: I A
authors.initials: IA
authors.lastname: Carneiro
mesh_terms: D004197:Disease Reservoirs; D014943:Global Health; D006801:Humans; D011051:Poliomyelitis / Q000517:prevention & control* / Q000635:transmission; D017955:Poliovirus / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral
chemical_list: D011055:Poliovirus Vaccine, Oral