Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI.
The feasibility of qualitative assessment of pulmonary perfusion using dynamic contrast enhanced MRI with ultra-short TE has recently been demonstrated. In the current study, quantitative analysis was attempted based on the indicator dilution principle using a pig model of pulmonary embolism. The results were compared with the absolute pulmonary perfusion obtained with colored microspheres. The inverse of apparent mean transit time (1/tau(app)), distribution volume (V), and V/tau(app) were correlated well with the absolute lung perfusion. This study demonstrates that MR has the potential to evaluate pulmonary perfusion quantitatively. Magn Reson Med 42:1033-1038, 1999.
Hatabu
H
H
Department of Radiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA. hhatabu@caregroup.harvard.edu
Tadamura
E
E
Levin
D L
DL
Chen
Q
Q
Li
W
W
Kim
D
D
Prasad
P V
PV
Edelman
R R
RR
D000328:Adult; D000818:Animals; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008168:Lung / Q000098:blood supply*; D008279:Magnetic Resonance Imaging; D008297:Male; D008863:Microspheres; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000473:pathology*; D013552:Swine; D014692:Ventilation-Perfusion Ratio
D003287:Contrast Media; D019786:Gadolinium DTPA