Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy.
We have observed a falsely lateralizing mesial temporal [11C]-flumazenil binding asymmetry in three patients who had temporal lobe epilepsy (TLE) with normal hippocampal volumes. This abnormality was not detected 3 months later in two of the patients who underwent a second PET study. We conclude that transient and falsely lateralizing changes of flumazenil binding might occur in patients with TLE and no hippocampal sclerosis.
Ryvlin
P
P
Department of Functional Neurology and Epileptology, CERMEP, Neurological Hospital, Lyon, France.
Bouvard
S
S
Le Bars
D
D
Mauguière
F
F
D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005442:Flumazenil / Q000493:pharmacokinetics*; D006624:Hippocampus / Q000000981:diagnostic imaging; D006801:Humans; D012016:Reference Values; D013997:Time Factors; D014055:Tomography, Emission-Computed
D005442:Flumazenil