Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma.
We examined the effect of Dai-kenchu-to (DKCT), a traditional Chinese (Kampo) medicine, on the levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in plasma from 24 healthy subjects. A single oral administration of DKCT, at a dose of 7.5 g, caused significant increases in plasma motilin levels (about 12 pg/ml) at 60 to 90 min, compared with a placebo-treated group. Transient elevations of gastrin levels were noted after administration of both DKCT (25.9+/-1.4 pg/ml) and placebo (23.5+/-1.3 pg/ml). DKCT did not alter the levels (about 5.7 pg/ml) of somatostatin. In conclusion, these results indicate that the action of DKCT closely relates to changes in motilin-immunoreactive substance levels in human plasma.
Nagano
T
T
Department of Clinical Pharmacy, Oita Medical University, Japan.
Itoh
H
H
Takeyama
M
M
D000284:Administration, Oral; D000328:Adult; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D020835:Medicine, Kampo; D009037:Motilin / Q000097:blood*; D005894:Panax; D004364:Pharmaceutical Preparations; D010936:Plant Extracts / Q000494:pharmacology*; D013004:Somatostatin / Q000097:blood*; D032106:Zanthoxylum; D030521:Zingiberaceae
D005755:Gastrins; D004364:Pharmaceutical Preparations; D010936:Plant Extracts; C121414:dai-kenchu-to; D013004:Somatostatin; D009037:Motilin