Therapeutic perspectives in HIV-1 infection from recent advances in HIV-1 pathogenesis: it is time to move on.
The recent availability of highly active antiretroviral combination therapy (HAART) has significantly influenced the natural history of the infection, delaying the progression to overt AIDS and prolonging survival. At the same time, the increasing knowledge on the pathogenic mechanisms an the use of HAART have challenged the most widely accepted theories about HIV-1 disease, in particular about the feasibility to eradicate the virus. This review will outline what is and what is not achievable by HAART, and will discuss new concepts in the immunopathogenesis of HIV-1 infection that provide the rationale for the design of new therapeutic approaches in the management of HIV-1 disease and AIDS.
Rizzardi
G P
GP
Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Switzerland.
Pantaleo
G
G
D019380:Anti-HIV Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology*; D015497:HIV-1 / Q000302:isolation & purification / Q000502:physiology; D006801:Humans
D019380:Anti-HIV Agents