title: Anxiolytic and hypnotic use in 376 psychiatric inpatients. GERMED Neuropsychotropics Group.
abstract: This objectives of this study were three-fold: retrospectively evaluate anxiolytic/hypnotic consumption by psychiatric inpatients, identify the risk factors of prolonged intakes, and prospectively measure the impact of hospitalisation on the use of those drugs. Three hundred and seventy-six patients hospitalised in 11 psychiatric departments in the Paris region were studied using a structured interview for the anxiolytic/hypnotic treatments, DSM-III-R criteria, GHQ-12, HAD, Spiegel's questionnaire, COVI's anxiety scale and the CGI. Eighty-five per cent of the patients had taken one anxiolytic/hypnotic or more in the 3 months preceding hospitalisation. Hospitalisation induced little change in anxiolytic/hypnotic use: dosage frequency increased from 77% to 84% between the week preceding hospitalisation and that preceding discharge; 26% of consumers were taking at least two anxiolytics or two hypnotics in the first period vs. 23% in the second. The absence of withdrawal during hospitalisation was related to the high age and a diagnosis of depression rather than schizophrenia, to the existence of continuous intake over the 3 months preceding hospitalisation and to higher drug doses during the 7 days preceding hospitalisation. Prescription of treatment at the end of hospitalisation in previously non-user subjects was related to a higher HAD anxiety score at discharge.
authors.affiliation: Department of Psychiatry, Department of Psychiatry, Centre Hospitalo-Universitaire de Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin Bicêtre, France.
authors.forename: P
authors.initials: P
authors.lastname: Hardy
authors.forename: C
authors.initials: C
authors.lastname: Payan
authors.forename: J C
authors.initials: JC
authors.lastname: Bisserbe
authors.forename: J P
authors.initials: JP
authors.lastname: Lepine
mesh_terms: D014151:Anti-Anxiety Agents; D003866:Depressive Disorder / Q000175:diagnosis; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000534:rehabilitation*; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D011795:Surveys and Questionnaires
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives