title: Pathogenesis of Mycobacterium avium subspecies paratuberculosis infections in ruminants: still more questions than answers.
abstract: Mycobacterium avium subspecies paratuberculosis is the etiologic agent of paratuberculosis (Johnes disease), a chronic enteritis in ruminants, which is one of the most widespread bacterial diseases of domestic animals, causing enormous economic losses worldwide. Though the disease was first described more than a century ago, the biology of the infecting organism and the mechanisms of its interactions with the host still remain a mystery. In this review, recent advances made on pathogenesis of paratuberculosis are summarized and future challenges are discussed.
authors.affiliation: Institut für Mikrobiologie und Tierseuchen, Tierärztliche Hochschule, Hannover, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Valentin-Weigand
authors.forename: R
authors.initials: R
authors.lastname: Goethe
mesh_terms: D000818:Animals; D016927:Mycobacterium avium subsp. paratuberculosis / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D010283:Paratuberculosis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D012418:Ruminants / Q000382:microbiology*