Effect of diacerein on spontaneous polyarthritis in male New Zealand black/KN mice.
OBJECTIVE
Male New Zealand black/KN (NZB/KN) mice spontaneously develop polyarthritis, characterized by destructive damages to the articular cartilage and bone. We assessed effects of diacerein in male NZB/KN mice by radiographic and histopathologic examinations.


METHODS
Diacerein, cyclosporin A or vehicle for the control were orally administered for 7 months, initiating at 8 weeks of age when the arthritis became apparent.


RESULTS
At 39 weeks of age, the NZB/KN mice developed polyarthritis in the joints of the forelimbs and hind legs, radiographically characterized by joint space narrowing, deformation of the joint surfaces, and bone erosions. Histopathologic findings showed that the tarsal joints and knee sections from the NZB/KN mice exhibited overt arthritic lesion. Radiographic and histopathologic findings showed that diacerein and cyclosporin A at a dose of 30 mg/kg/day significantly reduced the progression of arthritis.


CONCLUSIONS
Diacerein shows articular protecting effects against the development of spontaneous arthritis in male NZB/KN mice and diacerein might be useful in the treatment of chronic inflammatory joint diseases during clinical use.
Tamura
T
T
Drug Development Research Laboratories, Pharmaecutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Suntou-gun, Shizuoka, Japan.
Ohmori
K
K
Nakamura
K
K
D000818:Animals; D000880:Anthraquinones / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001168:Arthritis / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control*; D016572:Cyclosporine / Q000627:therapeutic use; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D011859:Radiography
D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018501:Antirheumatic Agents; C025292:diacerein; D016572:Cyclosporine