Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden.
We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.
Enlund
F
F
Department of Clinical Genetics, Gothenburg University, Sahlgrenska University Hospital, Sweden.
Samuelsson
L
L
Enerbäck
C
C
Inerot
A
A
Wahlström
J
J
Yhr
M
M
Torinsson
A
A
Riley
J
J
Swanbeck
G
G
Martinsson
T
T
D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005190:Family; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D011565:Psoriasis / Q000235:genetics*; D013548:Sweden