title: Osteosarcoma: oncologic and functional results. A single institutional report covering 22 years.
abstract: OBJECTIVE
  The oncologic and functional results in patients treated because of osteosarcoma (OS) were evaluated.
  
  
  METHODS
  Fifty-one patients with high-grade OS were treated between 1974 and 1996 at our hospital. All patient records were studied, and the surviving patients were evaluated according to the American Musculoskeletal Tumor Society functional rating system. The majority of patients received adjuvant chemotherapy (prior to 1983) or neoadjuvant chemotherapy (from 1983). Until 1987, all patients with extremity OS had ablative surgery; from 1987, the majority had limb-saving surgery. Lung metastases were resected in most cases.
  
  
  RESULTS
  Overall 2-year and 5-year disease-free survival (DFS) rates were 27 of 51 and 16 of 42, respectively. Patients with vertebral or pelvic OS or contaminated margins after resection had a very bad outcome. In all other subgroups, including patients with various types of chemotherapy, response to chemotherapy, diameter of tumor, presence or absence of metastatic spread, and location of tumor, a 5-year DFS of about 50% was found. Recurrent disease in patients who had achieved a 2-year disease-free interval was relatively low (4/23 patients).
  
  
  CONCLUSIONS
  Survival in our series was worse than in most other studies. A very bad outcome was found in patients with vertebral or pelvic OS or with contaminated margins after resection.
authors.affiliation: Department of Orthopaedics, Nijmegen University Hospital, Nijmegen, The Netherlands. A.Renard@orthp.azn.nl
authors.forename: A J
authors.initials: AJ
authors.lastname: Renard
authors.forename: R P
authors.initials: RP
authors.lastname: Veth
authors.forename: H W
authors.initials: HW
authors.lastname: Schreuder
authors.forename: M
authors.initials: M
authors.lastname: Pruszczynski
authors.forename: J P
authors.initials: JP
authors.lastname: Bökkerink
authors.forename: Q G
authors.initials: QG
authors.lastname: van Hoesel
authors.forename: F J
authors.initials: FJ
authors.lastname: van Der Staak
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012516:Osteosarcoma / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy