Hippocampal dysplasia in rats exposed to cocaine in utero.
Prenatal cocaine exposure can result in neurobehavioral disturbances and structural modifications of the central nervous system. In the present study, cocaine was injected into pregnant rats and the brains of their offspring were examined at the light microscopic level. As adults, cocaine-exposed offspring exhibited subtle, but consistent, hippocampal abnormalities. In particular, the stratum pyramidale (particularly the CA1 region) was interrupted by frequent gaps in lamination, and ectopic pyramidal cells were found in stratum oriens and radiatum.
Baraban
S C
SC
Departments of Pediatrics and Neuroscience, MTH 6090, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH, USA.
Wenzel
H J
HJ
Castro
P A
PA
Schwartzkroin
P A
PA
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D002465:Cell Movement; D003042:Cocaine / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000002:abnormalities* / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017966:Pyramidal Cells / Q000473:pathology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley
D003042:Cocaine