title: Hormones, genes and the structure of sexual arousal.
abstract: Despite the inherent difficulty of connecting individual genes with integrated mammalian behaviors, it has been determined that a series of genes are turned on by estrogenic hormones acting in forebrain. Their products are, in turn, facilitatory for female reproductive behaviors such as lordosis. The causal routes by which two genes contribute to the control of lordosis behavior, the classical estrogen receptor gene (ER-alpha) and a thyroid hormone (TH) receptor gene (TR-beta), have been delineated. Beyond the mechanisms underlying the expression of concrete, specific natural behaviors, lies the question of sexual motivation. Required as an intervening variable to explain fluctuations in natural behaviors in the face of constant stimuli, motivational states have both general and specific features. Most theoretical and experimental approaches toward the general aspects of motivation have depended heavily on concepts of 'arousal.' Sexual arousal is likely to depend both on very general, broadly distributed neuronal influences and on specific affiliative and sexual tendencies. Is 'general arousal' a monolithic, undifferentiated process? In no way can a review at this time settle such issues, but the reasons behind six new experimental approaches to these questions are described.
authors.affiliation: Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA. pfaff@rockvax.rockefeller.edu
authors.forename: J
authors.initials: J
authors.lastname: Frohlich
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Morgan
authors.forename: L
authors.initials: L
authors.lastname: Burton
authors.forename: D
authors.initials: D
authors.lastname: Pfaff
mesh_terms: D000818:Animals; D001143:Arousal / Q000235:genetics* / Q000502:physiology; D005260:Female; D015870:Gene Expression; D012739:Gonadal Steroid Hormones / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D009042:Motivation; D016548:Prosencephalon / Q000502:physiology; D011960:Receptors, Estrogen / Q000235:genetics / Q000502:physiology; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000502:physiology; D012725:Sexual Behavior / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*
chemical_list: D012739:Gonadal Steroid Hormones; D011960:Receptors, Estrogen; D011988:Receptors, Thyroid Hormone