title: Multiple drug resistance.
abstract: Multiple drug resistance to antibacterial agents, antifungals, antivirals, antiprotozoals, and antitumor agents has risen spectacularly in the last decade or so and presently threatens eventually to put an end to successful chemotherapy in all of the above fields. This review summarizes the known origins of the problem, its present dimensions, the means employed to combat the phenomenon and promising avenues for future developments.
authors.affiliation: Department of Medicinal Chemistry, Kansas University, Lawrence, Kansas 66045-2506, USA. lmitscher@rx.pharm.ukans.edu
authors.forename: L A
authors.initials: LA
authors.lastname: Mitscher
authors.forename: S P
authors.initials: SP
authors.lastname: Pillai
authors.forename: E J
authors.initials: EJ
authors.lastname: Gentry
authors.forename: D M
authors.initials: DM
authors.lastname: Shankel
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D006801:Humans
chemical_list: D000890:Anti-Infective Agents