[The modulation of the pharmacological effect of a number of substances by the mineral composition of the diet].
In acute and chronic experiments on rats (intact animals and animals with model circulatory insufficiency) which received 4 variants of the mineral additives over a period of 1-2 months the effect of mesatonum, isadrinum, and tiramine on the arterial pressure or furosemide and dichlorthiazide on the renal excretion function are studied. It is found that a substituent of the coom salt, hyposol, modulates in strength and in duration the hemodynamic effects of adrenergic drugs and renal excretion of electrolytes and water upon introduction of diuretics. On the whole, the effect of hyposol is aimed at attaining the favourable regime of functioning of the circulatory system.
Branchevskiĭ
L L
LL
Ivanovskii State Medical Academy, Ivanovo, Russia.
Shtrygol'
S Iu
SIu
D018663:Adrenergic Agents / Q000494:pharmacology*; D000643:Ammonium Chloride / Q000494:pharmacology; D000818:Animals; D002125:Calcium Gluconate / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D004032:Diet; D004232:Diuretics / Q000494:pharmacology*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*
D018663:Adrenergic Agents; D004232:Diuretics; D004338:Drug Combinations; C094275:Hyposol; D000643:Ammonium Chloride; C094274:sanasol; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D002125:Calcium Gluconate