Neuroprotective role of curcumin from curcuma longa on ethanol-induced brain damage.
In the present study, curcumin from Curcuma longa was screened for neuroprotective activity using ethanol as a model of brain injury. Oral administration of curcumin to rats caused a significant reversal in lipid peroxidation, brain lipids and produced enhancement of glutathione, a non-enzymic antioxidant in ethanol intoxicated rats, revealing that the antioxidative and hypolipidaemic action of curcumin is-responsible for its protective role against ethanol induced brain injury.
Rajakrishnan
V
V
Department of Biochemistry, Annamalai University, Annamalai Nagar-608 002, India.
Viswanathan
P
P
Rajasekharan
K N
KN
Menon
V P
VP
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003474:Curcumin / Q000494:pharmacology*; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity*; D015227:Lipid Peroxidation; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019862:Zingiberales / Q000737:chemistry*
D018696:Neuroprotective Agents; D000431:Ethanol; D003474:Curcumin