[Regenerative potential of the sensory epithelium of the mammalian organ of Corti after poisoning with ototoxic antibiotics].
Cochlear sensory hair cells are very sensitive to noxious influences such as ageing, noise and ototoxic drugs. Whereas lost auditory hair cells are replaced by new hair cells in the avian and lower vertebrates, cochlear sensory hair cells do not regenerate in mammals. Recently, we have observed transient atypical cells in the cochlea of amikacin intoxicated rats. We have related their presence to an attempt at sensory hair cell neodifferentiation. The aim of the present study was to i) investigate the mechanisms responsible for sensory hair cell losses during the intoxication and the subsequent appearance of atypical cells, ii) characterise the phenotype of these atypical cells and iii) evaluate the influence of cochlear immaturity in such an attempt at sensory hair cells neo-differentiation.
Vago
P
P
Histologie-Embryologie-Cytogénétique, Université Montpellier I, Faculté de Médecine de Montpellier-Nîmes, France. vago@infobiogen.fr
Parietti
C
C
Daudet
N
N
Humbert
G
G
Gallégo
M
M
Pujol
R
R
Lenoir
M
M
D000583:Amikacin / Q000506:poisoning*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000506:poisoning*; D002454:Cell Differentiation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D004848:Epithelium / Q000502:physiology; D006198:Hair Cells, Auditory / Q000502:physiology; D009925:Organ of Corti / Q000502:physiology*; D010641:Phenotype; D051381:Rats; D012038:Regeneration; D011984:Sensory Receptor Cells / Q000502:physiology*
D000900:Anti-Bacterial Agents; D000583:Amikacin