Disproportional body growth in female estrogen receptor-alpha-inactivated mice.
Estrogens play an important role in the regulation of longitudinal bone growth in man, as demonstrated by recent descriptions of individuals with estrogen insensitivity or aromatase deficiency. Two estrogen receptors, ERalpha and ERbeta, have been cloned. The aim of the present study was to investigate the function of ERalpha in the regulation of body growth and skeletal growth. Adult female mice with inactivated ERalpha (ERalpha-/-) demonstrated an increased body weight compared with wild-type mice (114% of control). However, the length of the appendicular skeleton was decreased in adult ERalpha-/- mice (femur 93% of control). In contrast, the axial skeleton was normal (crown-rump length 98% of control). The decreased growth of the appendicular skeleton was associated with decreased serum levels of IGF-I (77% of control), indicating that the GH/IGF-I axis may be involved in the decreased longitudinal bone growth seen in female ERalpha-/- mice.
Vidal
O
O
Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, Göteborg, S-41345, Sweden.
Lindberg
M
M
Sävendahl
L
L
Lubahn
D B
DB
Ritzen
E M
EM
Gustafsson
J A
JA
Ohlsson
C
C
D000818:Animals; D001483:Base Sequence; D001835:Body Weight / Q000235:genetics / Q000502:physiology; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D017931:DNA Primers / Q000235:genetics; D047628:Estrogen Receptor alpha; D005260:Female; D006128:Growth / Q000235:genetics / Q000502:physiology*; D006132:Growth Plate / Q000254:growth & development; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009929:Organ Size / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D011960:Receptors, Estrogen / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity
D017931:DNA Primers; D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D007334:Insulin-Like Growth Factor I