[Effect of vitamin A palmitate on vitamin A-deficient rabbits].
OBJECTIVE
We examined the effects of vitamin A palmitate (VA pal) eyedrops on the symptoms caused by vitamin A-deficiency in rabbits.


METHODS
Three-week-old rabbits were raised on a vitamin A-deficient diet, and were examined for the quantity of retinol in the serum and the condition of the anterior segment of the eye. The vitamin A-deficient animals were treated with VA pal eyedrops.


RESULTS
The retinol in the serum began to decrease seven months after the animals were placed on the vitamin A-deficient diet. After ten months, superficial punctate keratitis and the loss of conjunctival goblet cells were observed. Treatment of the disease in the anterior segment of the eyes with VA pal eyedrops resulted in restoration of normal condition within 3 weeks. The treatment increased the goblet cells in the ocular conjunctiva and the retinol in the serum.


CONCLUSIONS
These results show the efficacy of topical VA pal treatment for vitamin A-deficient rabbits.
Kubo
Y
Y
Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan.
Arimura
A
A
Watanabe
Y
Y
Nakayasu
K
K
Kanai
A
A
D000818:Animals; D000869:Anterior Eye Segment / Q000187:drug effects / Q000473:pathology*; D004224:Diterpenes; D008297:Male; D009883:Ophthalmic Solutions; D011817:Rabbits; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014802:Vitamin A Deficiency / Q000188:drug therapy* / Q000473:pathology
D004224:Diterpenes; D009883:Ophthalmic Solutions; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate