title: Synthesis and antimycobacterial activity of some heteroarylcarboxamidrazone derivatives.
abstract: A series of pyridine-2-, pyrazine-2- and quinoline-2-carboxamidrazone derivatives was prepared in an automated fashion and tested against Mycobacterium fortuitum in a rapid screen. Seven pyridine-2-carboxamidrazone derivatives were investigated further and four were found to have inhibitory activity with compound 4af being the most active. The structure activity implications are discussed.
authors.affiliation: Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Billington
authors.forename: M D
authors.initials: MD
authors.lastname: Coleman
authors.forename: J
authors.initials: J
authors.lastname: Ibiabuo
authors.forename: P A
authors.initials: PA
authors.lastname: Lambert
authors.forename: D L
authors.initials: DL
authors.lastname: Rathbone
authors.forename: K J
authors.initials: KJ
authors.lastname: Tims
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001331:Automation; D004353:Drug Evaluation, Preclinical; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019907:Mycobacterium fortuitum / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D006835:Hydrazones