Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.
Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.
Milton
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Department of Molecular Pathology, Royal Free and University College Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, U.K. nmilton@rfhsm.ac.uk
D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000633:toxicity; D002374:Catalase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism / Q000633:toxicity; D011485:Protein Binding
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D006861:Hydrogen Peroxide; D002374:Catalase