Effect of red wine consumption on low-density lipoprotein oxidation and atherosclerosis in aorta and coronary artery in Watanabe heritable hyperlipidemic rabbits.
Red wine was given to Watanabe heritable hyperlipidemic (WHHL) rabbits (7 mL/kg/day, approximately 23 mg total polyphenol/kg/day) from the age of 4 months for 14 months. With WHHL rabbits given a comparable dose of alcohol used as references, the effect of wine phenolics on the morphology of atherosclerotic lesions in the coronary artery and aorta was investigated in light of the susceptibility of plasma intermediate and low-density protein (ILDL) to oxidation. ILDL of animals consuming red wine showed reduced susceptibility to oxidation, but atherosclerotic lesion progression was not prevented. In WHHL rabbits, a dose of wine phenolics sufficient to inhibit ILDL oxidation might not be adequate to prevent the progression of atherosclerosis morphologically.
Wakabayashi
Y
Y
Department of Medicine, University of Kitasato Medical School, 1-15-1 Kitasato, Sagamihara 228-8555, Japan. yasiwaka@med.kitasato-u.ac.jp
D000428:Alcohol Drinking; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism*; D006949:Hyperlipidemias / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits; D014920:Wine
D008077:Lipoproteins, LDL