Ongoing protocols for non-AIDS primary central nervous system lymphoma.
The optimal treatment for primary central nervous system lymphoma (PCNSL) remains undefined. In this paper, we review the main multi-institutional ongoing protocols for PCNSL. Most of the current protocols evaluate the efficacy of combination high-dose methotrexate-based chemotherapy and brain irradiation in phase II studies. Some trials focus on chemotherapy alone as initial treatment, in order to minimize long-term cognitive sequellae. Because old age appears as a major predisposing factor for combined RT and CT neurotoxicity some specific protocols have been proposed to this particular population.
Hoang-Xuan
K
K
Clinique Neurologique et INSERM U495, Division Mazarin, Hôpital de la Salpêtrière, Paris, France.
Delattre
J Y
JY
D016543:Central Nervous System Neoplasms / Q000628:therapy*; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D015337:Multicenter Studies as Topic