Synthesis and antimycobacterial activity of some heteroarylcarboxamidrazone derivatives.
A series of pyridine-2-, pyrazine-2- and quinoline-2-carboxamidrazone derivatives was prepared in an automated fashion and tested against Mycobacterium fortuitum in a rapid screen. Seven pyridine-2-carboxamidrazone derivatives were investigated further and four were found to have inhibitory activity with compound 4af being the most active. The structure activity implications are discussed.
Billington
D C
DC
Pharmaceutical Sciences Institute, Aston University, Aston Triangle, Birmingham, UK.
Coleman
M D
MD
Ibiabuo
J
J
Lambert
P A
PA
Rathbone
D L
DL
Tims
K J
KJ
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001331:Automation; D004353:Drug Evaluation, Preclinical; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D019907:Mycobacterium fortuitum / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D006835:Hydrazones