A pilot study on the antibodies to HHV-6 variants and HHV-7 in CSF of MS patients.
In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with MS or other neurological disorders by ELISA. Predominance in the positivity of IgG (67%) and IgM (44%) to HHV-6B over that of IgG (44%) with no detectable IgM to HHV-6A, and no antibodies to HHV-7 were found in the CSF of MS patients. None of these antibodies were found in the CSF of controls. This suggests that, intrathecal chronic active or primary HHV-6B infection might contribute to MS progression, while the local effects of HHV-6A and HHV-7 seem to be less important.
Ongrádi
J
J
National Institute of Dermato-Venereology, Budapest, Hungary.
Rajda
C
C
Maródi
C L
CL
Csiszár
A
A
Vecsei
L
L
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015654:Herpesvirus 6, Human / Q000276:immunology*; D016199:Herpesvirus 7, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology / Q000821:virology*; D010865:Pilot Projects
D007074:Immunoglobulin G; D007075:Immunoglobulin M