Effect of cerebrospinal fluid shunting on experimental syringomyelia: magnetic resonance imaging and histological findings.
The histological changes associated with syringomyelia after reduction of the syrinx size were investigated after cerebrospinal fluid shunting in experimental syringomyelia in the rabbit. Five weeks after syringomyelia was induced by the injection of kaolin into the cisterna magna in Japanese white rabbits, ventriculosubgaleal shunting or syringoepidural shunting were performed. After 1 week magnetic resonance (MR) imaging and histological examination were then carried out. Five of 11 shunted animals showed postoperative reduction of syrinx size on MR imaging. Grossly, some specimens showed cavity collapse and parenchymal healing, and others showed a small residual syrinx in the dorsal horn. The most dramatic histological changes occurred in the gray matter. Specimens with syrinx collapse showed rarefaction and tearing of the gray matter, with mild glial reaction. The edematous gray matter showed both degeneration and regeneration, with neuronal processes surrounded by edema fluid. Reactive astrocytes were observed mainly at the margin of the residual syrinx. Some astrocytic processes invested the extraaxonal space and gray matter lacked supportive tissue. Greater reduction of the syrinx after shunting operation was correlated with more regeneration and less degeneration, and the white matter was edematous and histological changes were milder. Syrinx shrinkage occurred after shunting in this experimental model of syringomyelia. The selective vulnerability of gray matter even after shunting may explain discrepancies between imaging findings and clinical features in this disease. The study supports the potential benefit from early treatment, considering the associated morphological findings of regeneration.
Takahashi
A
A
Department of Neurosurgery, Kobe University School of Medicine.
Tamaki
N
N
Kurata
H
H
Nagashima
T
T
Fujimoto
E
E
D000818:Animals; D002557:Cerebrospinal Fluid Shunts / Q000379:methods*; D004195:Disease Models, Animal; D007616:Kaolin; D008279:Magnetic Resonance Imaging; D009416:Nerve Regeneration; D010784:Photomicrography; D011817:Rabbits; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology; D013595:Syringomyelia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*
D007616:Kaolin