title: Effect of dietary lipid-lowering drugs upon plasma lipids and egg yolk cholesterol levels of laying hens.
abstract: To evaluate the effect of lipid-lowering agents upon egg quality, reproductive performance, plasma lipids, and egg yolk cholesterol levels, 30-week-old Shaver laying hens were fed a basal diet (commercial ration) supplemented with 0.1% probucol (PROB), 0.025% gemfibrozil (GEMF), or lovastatin at 0.0005% (LOV1), 0.001% (LOV2), or 0.0015% (LOV3) for a 12-week experimental period. It was observed that the supplementation of the drugs did not impair albumen and shell quality. Hen performance was not adversely affected. The depression in triglyceride concentrations approached statistical significance only in LOV2 (38.5%), and total cholesterol was significantly depressed in LOV2 (36.0%), LOV3 (36.8%), PROB (29.6%), and GEMF (30.4%) treatments. Egg cholesterol content, expressed per gram of yolk, was significant lowered in LOV1 (7.5%) and LOV3 (12. 7%).
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Cidade Universitária Armando de Salles Oliveira, Av. Orlando Marques de Paiva 87, São Paulo 05508-000, Brazil.
authors.forename: A V
authors.initials: AV
authors.lastname: Mori
authors.forename: C X
authors.initials: CX
authors.lastname: Mendonça
authors.forename: C O
authors.initials: CO
authors.lastname: Santos
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002645:Chickens; D002784:Cholesterol / Q000032:analysis*; D019587:Dietary Supplements; D004530:Egg Yolk / Q000737:chemistry*; D005260:Female; D015248:Gemfibrozil / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D008148:Lovastatin / Q000494:pharmacology; D011341:Probucol / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D008148:Lovastatin; D011341:Probucol; D015248:Gemfibrozil