Two single nucleotide polymorphisms (SNPs) in the CALL gene for association studies with IQ.
A number of genes underlie the molecular bases of intelligence. Among these is probably CALL, a novel member of the L1 gene family of neural cell adhesion molecules. By using the single strand conformation polymorphism (SSCP) protocol, we screened the regions of the CALL gene corresponding to the 5' and 3' untranslated regions (UTRs) of the CALL mRNA, searching for polymorphisms that could be useful in association studies in the field of intelligence. We report the finding of T-to-A and T-to-C single nucleotide polymorphisms (SNPs) in the 3' UTR of CALL. These SNPs have an index of heterozygosity of 0.13 and 0.10, respectively. Research is in progress to understand the association between these variants and high IQ.
Angeloni
D
D
Laboratory of Immunobiology, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702-1201, USA. andreazzolid@mail.ncifcrf.gov
Wei
M H
MH
Lerman
M I
MI
D020413:3' Untranslated Regions / Q000235:genetics; D020121:5' Untranslated Regions / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D039841:Leukocyte L1 Antigen Complex; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D019006:Neural Cell Adhesion Molecules / Q000235:genetics*; D010375:Pedigree; D017354:Point Mutation; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D039841:Leukocyte L1 Antigen Complex; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules