title: Intestinal absorption and permeability in paediatric short-bowel syndrome: a pilot study.
abstract: BACKGROUND
  Sugar absorption tests are an effective, noninvasive way to assess intestinal permeability. The role of intestinal barrier integrity in complications and outcome of short-bowel syndrome is not known. The purpose of the study was to evaluate whether such tests provide information on the status of intestinal mucosa of these patients.
  
  
  METHODS
  Six children with short-bowel syndrome--median age, 12 months, and median small bowel length at birth, 30 cm--had a sugar test with 3-o-methyl-D-glucose, D-xylose, D-rhamnose, and melibiose approximately 2 months after operation. The melibiose/L-rhamnose ratio was used as an index of permeability, and percentages of 3-o-methyl-D-glucose and D-xylose absorbed were used as indices of absorption. Parenteral nutrition requirement, bowel length, liver disease, recent sepsis, and bacterial overgrowth were recorded.
  
  
  RESULTS
  Three patients had increased permeability, and all of them had had a recent episode of sepsis and severe liver disease. All subjects had malabsorption of 3-o-methyl-D-glucose, and five of six had malabsorption of D-xylose and L-rhamnose. The absorption of 3-o-methyl-D-glucose correlated with bowel length (r2 = 0.78; P = 0.04), whereas the absorption of D-xylose correlated with parenteral requirement (r2 = 0.66; P = 0.04) at that time.
  
  
  CONCLUSIONS
  Increased permeability was observed in three of six patients with short-bowel syndrome associated with a recent episode of sepsis and severe liver disease. Other indices of malabsorption correlated significantly with different clinical features of the disease. A prospective larger scale study in a homogeneous population is indicated to assess at multiple points during the disease course whether the test can be helpful in the management of these patients.
authors.affiliation: Department of Child Health, Guy's, King's, St. Thomas School of Medicine, London, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: D'Antiga
authors.forename: A
authors.initials: A
authors.lastname: Dhawan
authors.forename: M
authors.initials: M
authors.lastname: Davenport
authors.forename: G
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: I
authors.initials: I
authors.lastname: Bjarnason
mesh_terms: D019325:3-O-Methylglucose / Q000378:metabolism; D000293:Adolescent; D002463:Cell Membrane Permeability; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000503:physiopathology; D008107:Liver Diseases / Q000150:complications; D008553:Melibiose / Q000378:metabolism; D010288:Parenteral Nutrition; D010865:Pilot Projects; D012210:Rhamnose / Q000378:metabolism; D018805:Sepsis / Q000150:complications; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000601:surgery; D014994:Xylose / Q000378:metabolism
chemical_list: D019325:3-O-Methylglucose; D008553:Melibiose; D014994:Xylose; D012210:Rhamnose