[Dysembryoplastic neuroepithelial tumors. Analysis of 16 cases].
OBJECTIVE
We report on 16 cases of dysembryoplastic Neuroepithelial tumor (DNT) treated in the Nancy University Hospital from 1987 to 1997.


METHODS
There were 9 males and 7 females. Mean age at onset of symptoms was 9.5 years (range: 3 months to 29 years) and the mean age at surgery was 16 years. Nine patients experienced partial complex seizures, 5 patients generalized seizures, 1 patient partial seizures with secondary generalization and one patient ataxia. The diagnosis of DNT was made under consideration of clinical, radiological and neuropathological features. All patients underwent surgery.


RESULTS
Removal of the tumor was complete for 10 patients, subtotal or partial for 6 patients. Histological examination revealed that 7 cases were specific forms of DNT due to the presence of the specific glioneuronal element. For the 9 remained cases, the diagnosis of DNT could only be made with the consideration of clinical and radiological features. Mean post-surgical follow-up was 3.5 years (range: 1-8 years). Eight patients were seizures-free, 7 had a significative reduction in seizures frequency with minimal anti-convulsivant treatment. The patient with ataxia remained unchanged. For the patients with partial resection of the tumor, follow-up MRI and CT scan showed no significant growth of the remnant and the remaining patients have had no recurrence to date.


CONCLUSIONS
The recognition of this surgically curable entity is mandatory. Knowledge of the good prognosis associated with the DNT is essential to avoid deleterious side effects of overtreatment by radiotherapy and/or chemotherapy.
Fomekong
E
E
Service de Neurochirurgie, Hôpital Saint-Julien, CHU, Nancy.
Baylac
F
F
Moret
C
C
Chastagner
P
P
Ducrocq
X
X
Marchal
J C
JC
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome