title: 5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia.
abstract: The polymorphic C677T mutation in the gene encoding 5,10 methylenetetrahydrofolate reductase has been shown to be a risk factor for pre-eclampsia in Japanese and European women when inherited as a homozygous trait. We attempted to verify these findings in a black African population with a high incidence of pre-eclampsia. No difference in frequency of the T-allele was observed in 105 women with pre-eclampsia, compared with 110 healthy pregnant normotensive women. Only one woman with pre-eclampsia was TT homozygous, suggesting that methylenetetrahydrofolate reductase polymorphism is not an important factor in the pathogenesis of pre-eclampsia in black South African women.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Natal Medical School, Durban, South Africa.
authors.forename: A B
authors.initials: AB
authors.lastname: Chikosi
authors.forename: J
authors.initials: J
authors.lastname: Moodley
authors.forename: R J
authors.initials: RJ
authors.lastname: Pegoraro
authors.forename: P A
authors.initials: PA
authors.lastname: Lanning
authors.forename: L
authors.initials: L
authors.lastname: Rom
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics / Q000378:metabolism*; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy; D013019:South Africa
chemical_list: D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)