[Pathophysiologic significance of growth factors and new therapeutic concepts in cardiovascular disease].
Peptide growth factors such as PDGF, FGF, VEGF, and TGF-beta play a critical role in the pathogenesis of cardiovascular diseases. In addition to their pathophysiological role in atherosclerosis and myocardial remodeling, growth factors also promote beneficial effects such as stimulation of angiogenesis and formation of collateral vessels in ischemic tissue. This review focuses on the mechanisms of action and signal relay cascades of peptide growth factors, and summarizes novel therapeutic approaches in cardiovascular medicine. These approaches include both inhibition of growth factors in order to suppress pathogenic processes, and stimulation of growth factors to promote their beneficial effects.
Rosenkranz
S
S
Division of Basic Science, Schepens Eye Research Institute, Harvard Medical School, Boston, USA. rosenkranz@vision.eri.harvard.edu
Böhm
M
M
Kazlauskas
A
A
D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000378:metabolism / Q000627:therapeutic use; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism / Q000627:therapeutic use; D006131:Growth Inhibitors / Q000627:therapeutic use; D006133:Growth Substances / Q000819:agonists / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D008222:Lymphokines / Q000378:metabolism / Q000627:therapeutic use; D010982:Platelet-Derived Growth Factor / Q000378:metabolism / Q000627:therapeutic use; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000627:therapeutic use; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D006131:Growth Inhibitors; D006133:Growth Substances; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2