Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes.
The known compound bakuchiol (1) was isolated from an extract of Otholobium pubescens (Fabaceae) by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Oral administration of 1 reduced blood glucose levels in a dose-dependent fashion in db/db mice and did not display a hypoglycemic effect when tested in lean mice at 250 mg/kg q.d. Compound 1 was further evaluated in a new rodent model for type 2 diabetes, the fat-fed, streptozotocin (STZ)-treated rat. In this model, an oral dose of 1 at 150 mg/kg q.d. significantly lowered plasma glucose and triglyceride levels.
Krenisky
J M
JM
Shaman Pharmaceuticals, Inc., South San Francisco, California, 94080, USA.
Luo
J
J
Reed
M J
MJ
Carney
J R
JR
D000704:Analysis of Variance; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010568:Peru; D010636:Phenols / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D019685:Rosales / Q000737:chemistry*; D013311:Streptozocin; D013997:Time Factors
D007004:Hypoglycemic Agents; D010636:Phenols; D013311:Streptozocin; D005947:Glucose; C012765:bakuchiol