[Hepatotoxicity of cyclosporine in patients with kidney transplants].
In this study we have analyzed the liver transaminases levels in the 15 patients after kidney transplantation. All these patients have taken immunosuppressive cyclosporine therapy. The transaminases levels were determined by using the method Bergmayer kinetic ultraviolet test on the apparatus Tehnicon-Opera. The well known fact is the liver intoxication the same as kidney intoxication, if patients take cyclosporine for a long time. The average of the grafts in these patients were 9 years (ages between 1 and 16). The liver transaminases level was normal in all of groups of patients except for one who had high liver transaminases levels. After the correction cyclosporine therapy in the patient, the liver transaminases levels were normal. There was no possibility for monitoring of cyclosporine during the war, so the patients were determining the dose of cyclosporine on their own without any consulting with doctors. The most reliable method of cyclosporine applications is its determination, every day monitoring, and dosing by monitoring, which means concentrations in the reference values.
Karamehić
J
J
Zavod za farmakologiju i toksikologiju sa klinickom farmakologijom, Medicinski fakultet Univerziteta u Tuzli.
Ascerić
M
M
Tulumović
T
T
Kabil
E
E
Uzeirbegović
M
M
Hadzibegić
N
N
D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Ispitivanje hepatotoksicnosti ciklosporina u pacijenata sa transplantiranim bubrezima.