Methylsulfomycin I, a new cyclic peptide antibiotic from a Streptomyces sp. HIL Y-9420704.
Methylsulfomycin I (1) is a new cyclic peptide antibiotic isolated from the fermentation broth of a Streptomyces sp. HIL Y-9420704. Its structure was elucidated by NMR and GC-MS. The in vitro activity (MIC) against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-, and teicoplanin-resistant strains, is described.
Vijaya Kumar
E K
EK
Research Centre, Hoechst Marion Roussel Limited, Mulund (W), Mumbai-400 080, India.
Kenia
J
J
Mukhopadhyay
T
T
Nadkarni
S R
SR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D012997:Solvents; C402917:methylsulfomycin I