Selective RNA cleavage by isolated RNase L activated with 2-5A antisense chimeric oligonucleotides.
Silverman
R H
RH
Department of Cancer, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.
Dong
B
B
Maitra
R K
RK
Player
M R
MR
Torrence
P F
PF
D000227:Adenine Nucleotides / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D016367:Baculoviridae; D002678:Chimera; D002850:Chromatography, Gel / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D004722:Endoribonucleases / Q000302:isolation & purification / Q000378:metabolism*; D004789:Enzyme Activation; D005822:Genetic Vectors; D006801:Humans; D007700:Kinetics; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009843:Oligoribonucleotides / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D011994:Recombinant Proteins / Q000302:isolation & purification / Q000378:metabolism; D018411:Spodoptera; D013379:Substrate Specificity; D014162:Transfection; D019892:eIF-2 Kinase / Q000235:genetics*
D000227:Adenine Nucleotides; D020319:Oligodeoxyribonucleotides, Antisense; D009843:Oligoribonucleotides; D012333:RNA, Messenger; D011994:Recombinant Proteins; C023505:2',5'-oligoadenylate; D019892:eIF-2 Kinase; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease