title: Natural killer cells: stress out, turn on, tune in.
abstract: Natural killer cells attack tumor cells, infected cells and some normal cells, but the basis of their specificity is not completely understood. Recent studies indicate that epithelial tumor cells upregulate a stress-induced MHC class-I-like protein termed MICA, triggering NK cells via a recently described receptor called NKG2D.
authors.affiliation: Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Sciences Addition, University of California at Berkeley, Berkeley, 94720-3200, USA.
authors.forename: A
authors.initials: A
authors.lastname: Diefenbach
authors.forename: D H
authors.initials: DH
authors.lastname: Raulet
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009363:Neoplasm Proteins / Q000276:immunology*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000276:immunology*; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: C120528:HCST protein, human; C492355:Hcst protein, mouse; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; C527085:KLRK1 protein, human; C527086:Klrk1 protein, mouse; C099187:MHC class I-related chain A; C098080:MICB antigen; D008565:Membrane Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009363:Neoplasm Proteins; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell