title: Optic neuropathy in sheep associated with overdosage of closantel.
abstract: This report describes clinical and pathological findings in 2 flocks in Brazil where blindness and deaths in sheep occurred after closantel overdosage. Depression, weakness, and blindness affected 37 animals and 17 died in 2 flocks of 190 animals. Two animals submitted for ophthalmic examination showed no inflammation in the anterior segment of both eyes; posterior segment evaluation by indirect ophthalmoscopy suggested retinal degeneration. One postmortem evaluation local spongy vacuolization was in several regions of the brain and the optical nerves had severe axonal degeneration.
authors.affiliation: Universidade Estadual Paulista Julio de Mesquita Filho, Departamento de Clinica, Cirurgia e Reproducao Animal, Aracatuba, SP, Brasil.
authors.forename: A S
authors.initials: AS
authors.lastname: Borges
authors.forename: L C
authors.initials: LC
authors.lastname: Mendes
authors.forename: A L
authors.initials: AL
authors.lastname: de Andrade
authors.forename: G F
authors.initials: GF
authors.lastname: Machado
authors.forename: J R
authors.initials: JR
authors.lastname: Peiro
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000506:poisoning*; D001766:Blindness / Q000139:chemically induced / Q000662:veterinary; D001938:Brazil; D062787:Drug Overdose; D009410:Nerve Degeneration / Q000139:chemically induced / Q000662:veterinary; D009900:Optic Nerve / Q000187:drug effects / Q000473:pathology; D009901:Optic Nerve Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D012162:Retinal Degeneration / Q000139:chemically induced / Q000662:veterinary; D012458:Salicylanilides / Q000506:poisoning*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D000871:Anthelmintics; D012458:Salicylanilides; C023342:closantel