3'-deoxyribonucleosides and their derivatives as anti-amoebic agents.
In general nucleoside analogues were found to possess in vitro amoebicidal property against trophozoites of Entamoeba histolytica. The acid-labile nature of these compounds completely destroyed their ability to cure caecal amoebiasis of rats. However the therapeutic efficacy of one of these compounds yielded most promising results, with 10% cures when it was administered as enteric coated formulation.
Ghosal
S
S
Central Drug Research Institute, Lucknow, India.
KrishnaPrasad
B N
BN
Khanna
M
M
Dwivedi
A K
AK
Singh
S
S
Kumar
A
A
Katti
S B
SB
D000563:Amebicides / Q000494:pharmacology*; D000818:Animals; D002429:Cecal Diseases / Q000188:drug therapy / Q000469:parasitology; D003853:Deoxyribonucleosides / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004748:Entamoeba histolytica / Q000187:drug effects; D004749:Entamoebiasis / Q000188:drug therapy; D005260:Female; D008297:Male; D051381:Rats; D013608:Tablets, Enteric-Coated
D000563:Amebicides; D003853:Deoxyribonucleosides; D013608:Tablets, Enteric-Coated