Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells.
The influence of polyethylene terephthalate (PET) on the release of platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (bFGF) by in vitro cultured human endothelial cells was assessed by enzyme immunoassay. No significant differences were observed in the production of PDGF-AB with respect to the negative control cultures. A significant increase was observed in the production of bFGF after 48 and 72 h with respect to the negative control cultures. It can be concluded that PET may induce an increase in the production of basic FGF in endothelial cells.
Cenni
E
E
Laboratory for Biocompatibility Research on Implant Materials, Instituti Ortopedici Rizzoli, Bologna, Italy.
Verri
E
E
Granchi
D
D
Gamberini
S
S
Corradini
A
A
Di Leo
A
A
Montanaro
L
L
Pizzoferrato
A
A
D001672:Biocompatible Materials / Q000633:toxicity*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia; D007700:Kinetics; D008070:Lipopolysaccharides / Q000633:toxicity; D008422:Materials Testing; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis / Q000378:metabolism*; D011093:Polyethylene Terephthalates / Q000633:toxicity*
D001672:Biocompatible Materials; D008070:Lipopolysaccharides; D010982:Platelet-Derived Growth Factor; D011093:Polyethylene Terephthalates; D016222:Fibroblast Growth Factor 2