title: NG2 expression in MLL rearranged acute myeloid leukaemia is restricted to monoblastic cases.
abstract: Expression of NG2 has been reported in the majority of paediatric acute leukaemia (AL) cases with MLL rearrangement. We demonstrated 7. 1 positivity in 2/3 paediatric and 4/11 adult MLL rearranged acute myeloid leukaemia (AML) but in 0/28 adult AML without MLL rearrangement, thus extending the 100% specificity to adult cases. Positivity correlated with stage of maturation arrest since it was found in 0/6 immature AML but in 6/8 monoblastic cases. These data demonstrate that, if NG2 expression in AL is the (in)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML. They also have practical implications for NG2 diagnostic screening strategies.
authors.affiliation: Haematology and Cytogenetics, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Mauvieux
authors.forename: E
authors.initials: E
authors.lastname: Delabesse
authors.forename: P
authors.initials: P
authors.lastname: Bourquelot
authors.forename: I
authors.initials: I
authors.lastname: Radford-Weiss
authors.forename: A
authors.initials: A
authors.lastname: Bennaceur
authors.forename: G
authors.initials: G
authors.lastname: Flandrin
authors.forename: F
authors.initials: F
authors.lastname: Valensi
authors.forename: E A
authors.initials: EA
authors.lastname: MacIntyre
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000235:genetics* / Q000378:metabolism; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein; D011509:Proteoglycans / Q000235:genetics* / Q000378:metabolism; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014407:Tumor Cells, Cultured; D000099216:Chondroitin Sulfate Proteoglycan 4
chemical_list: D000941:Antigens; D004268:DNA-Binding Proteins; D011495:Histone-Lysine N-Methyltransferase; D051788:Myeloid-Lymphoid Leukemia Protein; D011509:Proteoglycans; D014157:Transcription Factors; D000099216:Chondroitin Sulfate Proteoglycan 4; C497422:KMT2A protein, human