Non-syndromic hearing impairment: gene linkage and cloning.
Non-syndromic hearing impairment (NSHI) affects approximately 1:2000 newborns and is a significant cause of hearing loss in the elderly. Although the phenotype is quite similar, NSHI is extremely heterogeneous, with over 40 genetic loci now known. A number of the relevant genes have been cloned. These advances are impacting clinical practice and revolutionizing our understanding of the biology of hearing.
Smith
R J
RJ
Department of Otolaryngology, University of Iowa, Iowa City 52242, USA. richard-smith@uiowa.edu
Van Camp
G
G
D002874:Chromosome Mapping; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D058851:GPI-Linked Proteins; D008040:Genetic Linkage; D006311:Hearing Disorders / Q000151:congenital / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008562:Membrane Glycoproteins / Q000235:genetics; D010375:Pedigree; D010641:Phenotype
D017630:Connexins; D016326:Extracellular Matrix Proteins; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; C491350:TECTA protein, human; D000072259:Connexin 26