title: Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: summary of GAW11 contributions.
abstract: We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
authors.affiliation: Department of Genetics (L.A.), Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA.
authors.forename: L
authors.initials: L
authors.lastname: Almasy
authors.forename: I B
authors.initials: IB
authors.lastname: Borecki
mesh_terms: D000437:Alcoholism / Q000209:etiology / Q000235:genetics*; D004493:Education; D005192:Family Health; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D012307:Risk Factors; D012984:Software