title: Development and evaluation of a multiple-unit oral sustained release dosage form for S(+)-ibuprofen: preparation and release kinetics.
abstract: Mini-matrix tablets containing S(+)-ibuprofen have been prepared by the wet granulation method. The hydrophilic matrix was formed with either xanthan gum, karaya gum or hydroxymethylcellulose (HPMC) together with a choice of additives from lactose, Encompress(R), Avicel(R) PH101, talc and Lubritab(R). Multiple unit dosage forms (MUDFs) were subsequently obtained by encapsulating the mini-matrix tablets into hard gelatin capsules. Preparation, in vitro release profiles and release kinetics are presented.
authors.affiliation: School of Pharmacy, The Robert Gordon University, Aberdeen, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Cox
authors.forename: K A
authors.initials: KA
authors.lastname: Khan
authors.forename: D L
authors.initials: DL
authors.lastname: Munday
authors.forename: J
authors.initials: J
authors.lastname: Sujja-areevath
mesh_terms: D002214:Capsules; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D005780:Gelatin; D007052:Ibuprofen / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D007618:Karaya Gum / Q000737:chemistry; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D010078:Oxazines; D011135:Polysaccharides, Bacterial / Q000737:chemistry; D013223:Statistics as Topic; D013627:Talc / Q000737:chemistry; D013997:Time Factors
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D005079:Excipients; D010078:Oxazines; D011135:Polysaccharides, Bacterial; D013627:Talc; D007618:Karaya Gum; D005780:Gelatin; D002482:Cellulose; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; C002563:xanthan gum; D007052:Ibuprofen