Intracellular lectins associated with N-linked glycoprotein traffic.
The vectorial intracellular transport of N-glycan-linked glycoproteins is indispensable for biological functions. In order to sort these glycoproteins to the correct destination, animal intracellular lectins play important roles as sorting receptors. The roles of such lectins in the biosynthetic pathway from the endoplasmic reticulum (ER) to the cell surface are addressed in this review. Calnexin and calreticulin function via specific carbohydrates in quality control of newly synthesized glycoproteins in the ER, and ERGIC-53 seems to function in the transport of glycoproteins from ER to the Golgi complex. In addition to the well-understood role of mannose 6-phosphate receptor in lysosomal protein sorting, the vesicular integral protein of 36 kDa (VIP36) functions as a sorting receptor by recognizing high-mannose type glycans containing alpha1-->2Man residues for transport from Golgi to the cell surface in polarized epithelial cells.
Yamashita
K
K
Department of Biochemistry, Sasaki Institute, 2-2 Kanda-Surugadai, Chiyoda-ku, and CREST (Core Research for Evolutional Science and Technology) of the Japan Science and Technology Corporation (JST), Tokyo, Japan. yamashita@sasaki.or.jp
Hara-Kuge
S
S
Ohkura
T
T
D000818:Animals; D001692:Biological Transport; D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin; D037282:Calreticulin; D002240:Carbohydrate Sequence; D002352:Carrier Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D037102:Lectins / Q000378:metabolism*; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D012261:Ribonucleoproteins / Q000378:metabolism
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002352:Carrier Proteins; D006023:Glycoproteins; D037102:Lectins; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins; D012261:Ribonucleoproteins; D037281:Calnexin