Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile.
Uchida
H
H
Division of Organ Replacement Research, Jichi Medical School, Tochigi, Japan.
Kobayashi
E
E
Ogino
Y
Y
Mizuta
K
K
To
H
H
Okabe
R
R
Hashizume
K
K
Fujimura
A
A
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016332:Fetal Tissue Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D007422:Intestines / Q000637:transplantation*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D014183:Transplantation, Heterologous / Q000276:immunology*
D007166:Immunosuppressive Agents; D016559:Tacrolimus