Lipid-lowering medication and risk of injury.
Meta-analyses of early primary prevention trials of lipid-lowering therapies suggested increased risk of injury deaths among treated persons. Our population-based case-control study examined the association of lipid-lowering medication use with fatal and nonfatal injuries in 298 cases and 332 controls. No increased injury risk was observed among current (OR = 0.46, 95% CI 0.18-1.21) or past users (OR = .92, 95% CI 0.44-1.95), after adjustment for behavioral disorders, medical conditions, and health status. Stratified analyses did not reveal sub-groups at significantly increased risk. These results, consistent with recent clinical trials and meta-analyses, suggest no increased injury risk associated with lipid-lowering medications.
Bovbjerg
V E
VE
Department of Internal Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, USA.
Siscovick
D S
DS
Psaty
B M
BM
McCann
B S
BS
Koepsell
T D
TD
Raghunathan
T E
TE
Wagner
E H
EH
D000061:Accidents, Home / Q000401:mortality; D000063:Accidents, Traffic / Q000401:mortality; D000328:Adult; D002423:Cause of Death; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control; D005260:Female; D006304:Health Status; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D015994:Incidence; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D014861:Washington / Q000453:epidemiology; D014947:Wounds and Injuries / Q000453:epidemiology* / Q000209:etiology
D000960:Hypolipidemic Agents; D008055:Lipids