The anticonvulsive effect of glutathione in mice.
To explore the role of glutathione as a neuromodulator, we investigated effects of reduced (GSH) and oxidized glutathione (GSSG) on drug-induced convulsions in mice. Intracerebroventricular administration of GSH or GSSG (10-300 nmol) did not produce convulsions. When GSH was administered prior to subcutaneous administration of pentylenetetrazol (80 mg/kg), it significantly inhibited pentylenetetrazol-induced convulsions. The inhibitory effect of GSH was dose dependent, and mimicked by GSSG. In addition, neither GSH nor GSSG affected convulsions induced by subcutaneous administration of N-methyl-DL-aspartate (400 mg/kg). These findings suggest that glutathione has a specific anticonvulsive effect.
Abe
K
K
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Japan.
Nakanishi
K
K
Saito
H
H
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D005978:Glutathione / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D016202:N-Methylaspartate; D010084:Oxidation-Reduction; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000927:Anticonvulsants; D016202:N-Methylaspartate; D005978:Glutathione; D010433:Pentylenetetrazole