title: Complications in skull base surgery for malignancy.
abstract: OBJECTIVE
  To review a consecutive series of skull base surgeries, establish the rate of complications, and outline their prevention and management.
  
  
  METHODS
  A retrospective review of 107 consecutive intracranial/extracranial operations performed for malignancy that transgresses the skull base.
  
  
  METHODS
  The hospital charts of 107 operations performed on 98 patients at the University of California at Davis Medical Center. The type of operation, cause of death, and complications were noted.
  
  
  RESULTS
  The complication rate was 50.5%. Forty-eight patients had no complications. There were six perioperative deaths. The most common surgical complications were cerebrospinal fluid leak (11.2%), meningitis (4.8%), and wound breakdown (15%). The most common medical complications were pneumonia (6.5%), cardiac disturbance (4.7%), and electrolyte imbalance (3.7%). The only prior treatment that was accompanied by a significant increase in complications was previous surgery.
  
  
  CONCLUSIONS
  patients who had cranial base surgery for the intracranial spread of head and neck cancer. The perioperative death rate is less than 4%. The major complications were at an acceptable rate.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery and the Center for Skull Base Surgery, University of California, Davis, Sacramento, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Donald
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010039:Otorhinolaryngologic Neoplasms / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000401:mortality / Q000517:prevention & control / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D019292:Skull Base Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D017211:Treatment Failure