[The effect of cytochrome c on the myocardium during reperfusion].
Experimental and clinical trials have shown high effectiveness of cytochrome c (0.5 mg/kg) in prevention of reperfusion myocardial disorders in cardiosurgical patients. Cytochrome c inhibits development of myocardial ischemic contracture, depression of coronary circulation, activation of lipid peroxidation. It reduces myocardial consumption of oxygen and promotes earlier restoration of fatty acids metabolism under lower glucose consumption by the heart muscle. By correction of myocardial metabolism, the drug suppresses fermentemia in early reperfusion.
Boiarinov
G A
GA
Iakovlev
A Iu
AIu
Teziaeva
S A
SA
Mukhina
I V
IV
Boiarinova
L V
LV
D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003574:Cytochrome c Group / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011300:Preoperative Care; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D003574:Cytochrome c Group; D005609:Free Radicals
Vliianie tsitokhroma c na miokard vo vremia reperfuzii.