title: Stent-grafts for de novo TIPS: technique and early results.
abstract: OBJECTIVE
  To evaluate the potential benefits of placing a polytetrafluoroethylene (PTFE)-covered stent-graft during initial creation of a transjugular intrahepatic portosystemic shunt (TIPS) in clinical practice.
  
  
  METHODS
  De novo TIPS were created with a PTFE stent-graft in four male and four female patients with symptomatic portal hypertension awaiting liver transplant. Their ages ranged from 35 to 62 (mean, 47) years. Patients were followed with TIPS ultrasound (US) and/or venography until liver transplantation or death; one remains under active study. Six recovered specimens underwent gross and microscopic evaluation.
  
  
  RESULTS
  All TIPS placements were successful. Six shunts were primarily patent, with a mean patency of 289 days, through completion of the study. Five were found to be patent at transplant and one was found to be patent at autopsy. Explant evaluation revealed a smooth, thin layer of neointima and exclusion of biliary secretions. Three patients developed a total of four stenoses (one tandem lesion) during follow-up, leading to revision in two patients. Mean primary and total patency in these patients was achieved after 279 and 463 days, respectively. A previously occult moderate stenosis was detected after explant in another patient. Only one (nonsignificant) stenosis clearly developed in an area covered by PTFE.
  
  
  CONCLUSIONS
  Placement of a de novo PTFE stent-graft during TIPS creation is feasible and may extend primary shunt patency. Appropriate positioning of the stent-graft is critical.
authors.affiliation: Dotter Interventional Institute, Portland, Oregon 97201, USA. andrewro@ohsu.edu
authors.forename: R T
authors.initials: RT
authors.lastname: Andrews
authors.forename: R R
authors.initials: RR
authors.lastname: Saxon
authors.forename: R D
authors.initials: RD
authors.lastname: Bloch
authors.forename: B D
authors.initials: BD
authors.lastname: Petersen
authors.forename: B T
authors.initials: BT
authors.lastname: Uchida
authors.forename: J M
authors.initials: JM
authors.lastname: Rabkin
authors.forename: M M
authors.initials: MM
authors.lastname: Loriaux
authors.forename: F S
authors.initials: FS
authors.lastname: Keller
authors.forename: J
authors.initials: J
authors.lastname: Rösch
mesh_terms: D000328:Adult; D020099:Coated Materials, Biocompatible; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008670:Metals; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D011172:Portography; D011474:Prosthesis Design; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D008670:Metals; D011138:Polytetrafluoroethylene