title: Expression of endothelin A- and B-receptors in human nasal mucosa.
abstract: Several studies have suggested an important role for the endothelin (ET) family of peptides in the vascular regulation of the nose. In addition, there is increasing evidence that ETs play a role in allergic airway inflammation. Endothelin is produced locally in the nose and mediates its effects via two distinct receptor subtypes, termed ET(A) and ET(B). Using reverse transcriptase-polymerase chain reaction, mRNAs encoding ET(A)- and ET(B)-receptors were detected in the human lower turbinate and sinus mucosa. The possibility of local release of ETs in connection with specific target receptors suggests a role for endothelin in the regulation of vascular tone, glandular secretion and epithelial functions.
authors.affiliation: Department of Internal Medicine, Lund University Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Möller
authors.forename: R
authors.initials: R
authors.lastname: Uddman
authors.forename: L O
authors.initials: LO
authors.lastname: Cardell
authors.forename: G
authors.initials: G
authors.lastname: Fernström
authors.forename: L
authors.initials: L
authors.lastname: Edvinsson
mesh_terms: D000328:Adult; D001483:Base Sequence; D017931:DNA Primers; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009297:Nasal Mucosa / Q000378:metabolism*; D010256:Paranasal Sinuses / Q000378:metabolism; D012313:RNA / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D017422:Sequence Analysis, DNA; D014420:Turbinates / Q000378:metabolism
chemical_list: D017931:DNA Primers; D012333:RNA, Messenger; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin; D012313:RNA