Putting two and two together: crystal structure of the FGF-receptor complex.
The recently determined crystal structure of an FGF-receptor complex reveals a surprising architecture and a novel mode of receptor dimerization. The structure also elucidates the role of heparan sulfate proteoglycans in receptor activation, showing significant differences from previously proposed models.
Wiesmann
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Department of Protein Engineering, Genentech, Inc., Sunesis Pharmaceuticals, Inc., South San Francisco, Redwood City, CA 94080, USA.
de Vos
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AM
D018360:Crystallography, X-Ray; D005346:Fibroblast Growth Factors / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry*
D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors