title: Congenital heart defects and maternal derangement of homocysteine metabolism.
abstract: Methionine loading tests and folate, vitamin B(6), and vitamin B(12) analyses were performed in 27 mothers of children with congenital heart defects. Median fasting plasma homocysteine concentrations were significantly higher in the study group as compared with 56 control subjects (P =.0001). Maternal hyperhomocysteinemia may be a risk factor for congenital heart defects.
authors.affiliation: Children's Heart Center, Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Kapusta
authors.forename: M L
authors.initials: ML
authors.lastname: Haagmans
authors.forename: E A
authors.initials: EA
authors.lastname: Steegers
authors.forename: M H
authors.initials: MH
authors.lastname: Cuypers
authors.forename: H J
authors.initials: HJ
authors.lastname: Blom
authors.forename: T K
authors.initials: TK
authors.lastname: Eskes
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007223:Infant; D009035:Mothers; D049590:Postpartum Period; D012307:Risk Factors
chemical_list: D006710:Homocysteine