Sesquiterpene polyol esters from the leaves of maytenus macrocarpa
The aerial parts of Maytenus macrocarpa yielded three new beta-dihydroagarofuran sesquiterpene polyol esters. Their structures were elucidated by spectroscopic analyses including 2D NMR techniques as 6beta,8beta,15-triacetoxy-1alpha, 9alpha-dibenzoyloxy-4beta-hydroxy-beta-dihydroagarofuran (1); 1alpha, 6beta,8beta, 15-tetraacetoxy-9alpha-benzoyloxy-4beta-hydroxy-beta-dihydroagarofura n (2) and (1S,4S,6R,7R,8R,9R)-1,6,15-triacetoxy-8, 9-dibenzoyloxy-4-hydroxy-beta-dihydroagarofuran (3). Compounds 1 and 2 showed marginal antitumor activity against four cell lines.
Chavez
H
Instituto Universitario de Bio-Organica "Antonio Gonzalez", Universidad de La Laguna, Avenida Astrofisico Fco. Sanchez 2, 38206 Tenerife, Spain.
Callo
N
Estevez-Braun
A
Ravelo
AG
Gonzalez
AG