title: Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster.
abstract: We have identified a novel isoform of adenylyl cyclase, DAC78C, in Drosophila melanogaster that encodes two structurally distinct proteins in a developmentally restricted manner. The protein corresponding to one transcript is potently activated by G protein and protein kinase C and is expressed ubiquitously. The protein corresponding to the second transcript is expressed in a dynamic pattern in gastrulation stage embryos; it is restricted to the cephalic furrow and dorsal transverse folds, active regions of cell movement of unknown function in the Drosophila embryo. We propose that DAC78C and the cAMP pathway play an important role in directing these morphogenetic movements, and that this gene may provide clues to the functional significance of these structures in gastrulation.
authors.affiliation: Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue New York, NY 10021, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Cann
authors.forename: L R
authors.initials: LR
authors.lastname: Levin
mesh_terms: D000262:Adenylyl Cyclases / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D004331:Drosophila melanogaster / Q000196:embryology / Q000201:enzymology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D017344:Genes, Insect; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics; D008969:Molecular Sequence Data
chemical_list: D007527:Isoenzymes; D000262:Adenylyl Cyclases