Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits.
The purpose of this study was to characterize the ocular pharmacokinetics of a beta-blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretion deficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetration parameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits.
Sasaki
H
H
Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
Yamamura
K
K
Mukai
T
T
Nishida
K
K
Nakamura
J
J
Nakashima
M
M
Ichikawa
M
M
D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000465:Algorithms; D000758:Anesthesia; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D005123:Eye; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D013666:Tears / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D007546:Isoquinolines; C036593:tilisolol