title: Interaction between blood flow and motility in normal and inflamed ileum.
abstract: The alterations in local and superior mesenteric blood flow during ileal inflammation and their correlations with motility in the normal and the inflamed ileum were investigated in the conscious state. Ileal inflammation decreased the local mesenteric blood flow but had no significant effect on the superior mesenteric blood flow. A significant reduction or an increase in local mesenteric blood flow in the normal or the inflamed ileum had no effect on local contractile activity. The vascular reactivity to vaso-dilators and vaso-constrictors was significantly reduced during inflammation. Local mesenteric blood flow increased significantly in the descending segment ahead of a caudal propagating giant migrating contraction. The local mesenteric blood flow oscillated during a migrating motor complex (MMC) cycle. We conclude that a several-fold increase or decrease in local mesenteric blood flow lasting for several minutes does not affect contractility. Ileal inflammation decreases local mesenteric blood flow but does not affect the total blood flow to the small intestine.
authors.affiliation: Departments of Surgery and Physiology, Medical College of Wisconsin, and Zablocki VA Medical Center, Milwaukee, WI 53295, USA.
authors.forename: V E
authors.initials: VE
authors.lastname: Cowles
authors.forename: R P
authors.initials: RP
authors.lastname: Ryan
authors.forename: S K
authors.initials: SK
authors.lastname: Sarna
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D007079:Ileitis / Q000503:physiopathology*; D007082:Ileum / Q000098:blood supply* / Q000187:drug effects; D007261:Infusions, Intra-Arterial; D007421:Intestine, Small / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage / Q000494:pharmacology; D018721:Muscarinic Agonists / Q000008:administration & dosage / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D018721:Muscarinic Agonists; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D016210:Methacholine Chloride; D000804:Angiotensin II; D010646:Phentolamine