title: Loss of tissue immunoreactive androgen receptor in prostate cancer presenting initially as an intracranial tumor.
abstract: We report a case of prostate cancer that presented initially as an intracranial tumor. Biopsy specimens of the prostate before endocrine treatment were nearly negative immunohistochemically for prostate-specific antigen and the androgen receptors. All metastases including those in the brain expressed neither androgen receptor nor prostate-specific antigen at the protein and mRNA levels. The tumor, which did not respond to the anti-androgen therapy, had an aggressive course. In this case, the androgen-independent growth and rapid progression might be associated with the initial loss of the antigen and androgen characteristics of the prostate.
authors.affiliation: Department of Urology and Pathology, Gifu University School of Medicine, Gifu City, Japan. deguchit@cc.gifu-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ehara
authors.forename: M
authors.initials: M
authors.lastname: Yang
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Deguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawada
authors.forename: K
authors.initials: K
authors.lastname: Shimokawa
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary*; D001932:Brain Neoplasms / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis*
chemical_list: D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen