title: Parotid carcinoma as a second malignancy after treatment of childhood acute lymphoblastic leukemia.
abstract: The occurrence of second malignant neoplasms (SMN) in children who survive their primary malignancy is a major cause for concern. Two children with diagnoses of intermediate-risk acute lymphoblastic leukemia (ALL) at 22 months and 2 years of age were treated with multiagent chemotherapy and prophylactic cranial irradiation. They experienced painless parotid swelling 6 and 7 years after successful treatment of the ALL. The patients underwent total parotidectomy, and a diagnosis of mucoepidermoid carcinoma was made. Both patients experienced transient facial nerve paresis. The incidence of SMN in children successfully treated for primary malignancies is 3% to 12%. Salivary gland tumors are being increasingly described in this setting. Long-term follow-up for survivors of childhood ALL is recommended with prompt assessment and resection of parotid swellings, particularly in children who have received cranial irradiation.
authors.affiliation: Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109, USA.
authors.forename: L
authors.initials: L
authors.lastname: Prasannan
authors.forename: A
authors.initials: A
authors.lastname: Pu
authors.forename: P
authors.initials: P
authors.lastname: Hoff
authors.forename: R
authors.initials: R
authors.lastname: Weatherly
authors.forename: V
authors.initials: V
authors.lastname: Castle
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000517:prevention & control; D018277:Carcinoma, Mucoepidermoid / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology*; D010307:Parotid Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy*; D013997:Time Factors