Evaluation of change in blood flow by contrast-enhanced power Doppler imaging during norepinephrine-induced renal vasoconstriction.
We evaluated the changes in flow induced by intrarenal infusion of norepinephrine by an ultrasonographic contrast agent and power Doppler imaging. Hypoperfusion was induced in dogs (N = 5) by infusing norepinephrine directly into the renal artery for 30 min at doses of 0.7 microg/kg/min, 1.0 microg/kg/min, and 1.9 microg/kg/min. Contrast agent injections were made before and after each infusion of norepinephrine. The transit of contrast agent through the kidney and color enhancement were measured by computer analysis of power Doppler images. Mean transit time and effective renal plasma flow were measured. The effective renal plasma flow decreased by 29%, 30%, and 64%, respectively, with the increasing doses of norepinephrine. Paralleling this change, the mean transit time, which corresponds to reduction in renal blood flow, increased by 26%, 43%, and 77%, respectively, from the preinfusion value. Regression analysis shows renal blood flow to decrease exponentially with norepinephrine dose. Renal blood flow changes measured by contrast-enhanced imaging correlated closely with the effective renal plasma flow measurements. Computer analysis of contrast-enhanced power Doppler images allowed measurement of renal blood flow. This technique may be useful in assessing renal perfusion during pharmacologic and other therapeutic interventional procedures.
Arger
P H
PH
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.
Sehgal
C M
CM
Pugh
C R
CR
Kirchoffer
J I
JI
Kotlar
E Y
EY
Bovee
K C
KC
D000818:Animals; D003287:Contrast Media; D004285:Dogs; D005466:Fluorocarbons; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000502:physiology; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow; D018608:Ultrasonography, Doppler / Q000379:methods*; D014661:Vasoconstriction / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010420:Pentanes
D003287:Contrast Media; D005466:Fluorocarbons; D009638:Norepinephrine; D014662:Vasoconstrictor Agents; C008806:perfluoropentane; D010420:Pentanes