title: The presence of an endogenous endo-D-arabinase in Mycobacterium smegmatis and characterization of its oligoarabinoside product.
abstract: Endogenous mycobacterial endo-D-arabinase activity, which degrades cell wall polysaccharide arabinogalactan, was found in Mycobacterium smegmatis. The arabinan product contains 20-30 arabinosyl residues but no galactofuranosyl residues. Recognition of this endogenous activity results in the possibility of developing antituberculosis drugs that do not require bacterial growth for activity.
authors.affiliation: Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Xin
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: M R
authors.initials: MR
authors.lastname: McNeil
mesh_terms: D002473:Cell Wall / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004977:Ethambutol / Q000494:pharmacology; D005685:Galactans / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000201:enzymology*; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism
chemical_list: D005685:Galactans; D011134:Polysaccharides; C030080:araban; D004977:Ethambutol; C074451:Endo-arabinase; D006026:Glycoside Hydrolases; C005653:arabinogalactan