[The role of estradiol metabolites in prevention of cardiovascular diseases by hormone substitution in postmenopause].
Postmenopausal estrogen replacement therapy has shown to reduce cardiovascular disease by direct and indirect estradiol-mediated effects on the cardiovascular system. Recently, evidence is growing that estradiol metabolites may also have beneficial actions. In the present review the existing experimental data for vascular effects of estradiol metabolites are summarized. The results of our own experiments in addition to those of other groups indicate that estradiol metabolites, especially catechol estrogens, exert beneficial effects on the vascular system and perhaps may play a physiologic role in the cardiovascular system. Reference to clinical-pharmacological aspects for the use of estradiol metabolites for prevention and treatment of cardiovascular diseases is presented.
Lippert
T H
TH
Sektion Klinische Pharmakologie, Universitäts-Frauenklinik, Tübingen.
Seeger
H
H
Mueck
A O
AO
D000818:Animals; D001711:Biotransformation; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D002979:Climacteric / Q000187:drug effects* / Q000502:physiology; D004958:Estradiol / Q000502:physiology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D013329:Structure-Activity Relationship
D004958:Estradiol
Uber die Rolle von Ostradiolmetaboliten bei der Prävention kardiovaskulärer Erkrankungen durch Hormonsubstitution in der Postmenopause.