[Use of a novel hepato-protective preparation "phospholiv" for inhibition of development of chronic hepatitis in rats].
Protective influence of a new phospholipid preparation "Phospholiv" was studied using a model of chronic hepatitis. Animals were treated 45 days intraperitoneay with CCl4 with parallel intragastral administration of Phospholiv or--(for comparison)--the of other phospholipid hepatoprotector, Essential. Morphologic changes of liver, as well as protein and RNA biosynthesis were evaluated in the end of experiment--by means of measuring C14-leucine and C14-orotic acid incorporation into hepatocyte subcellular fractions. Both phospholipid preparations attenuated dystrophic liver changes, Phospholiv effect being more pronounced. They both prevented CCl4 induced inhibition of label incorporation into subcellular fraction proteins, but only Phospholiv, promoted the maintaining normal level of radioactivity incorporation into cytosol proteins and hepatocyte RNA. The results, confirming certain protective effect of Essential, show more pronounced hepatoprotective action of the new preparation Phospholiv (developed on the basis of polyunsaturated phosphatidylcholine and glycyrrhizinic acid salt). Data show also on possible fit hepatitis treatment.
Ipatova
O M
OM
Institute of Biomedical Chemistry, Moscow.
Torkhovskaia
T I
TI
Kniazhev
V A
VA
Karuzina
I I
II
Bachmanova
G I
GI
Guseva
M K
MK
Archakov
A I
AI
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004338:Drug Combinations; D019695:Glycyrrhizic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006520:Hepatitis, Animal / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D051381:Rats
D004338:Drug Combinations; D010713:Phosphatidylcholines; C404946:phospholiv; C011246:essential 303 forte; D012313:RNA; D019695:Glycyrrhizic Acid
Tormozhenie s pomoshch'iu novogo gepato-protektornogo preparata "fosfoliv" razvitiia khronicheskogo gepatita u krys.