title: [Hormone evaluation in brain death].
abstract: BACKGROUND
  In this study, the level and the variation of a number of hormone and metabolic parameters during brain death treatment in potential organ donors have been monitored.
  
  
  METHODS
  Thirty-nine consecutive brain-dead patients were enrolled in 3 Intensive Care Units of Regional Hospitals of the North of Italy. All patients were potential organ donors and free from diseases before the accident leading to death. The levels of ADH, ACTH, TSH, prolactin, cortisol, aldosterone, FT3, FT4, renin, serum lactate and plasma osmolality were measured immediately after the diagnosis of brain death (T0), certified following the Italian law of December 29, 1993, n. 578, and after 6 hours (T6).
  
  
  RESULTS
  Hormone levels were normal in the majority of subjects, and there was no significant variation during the 6 hours of the observation period. No correlation was found between the hormone levels considered and the metabolic parameters; ADH levels were not correlated with plasma osmolality. FT3 levels were below the normal range in the majority of subjects, but were not associated with a higher lactate level, which is used as a marker of a shift toward tissue anaerobic metabolism.
  
  
  CONCLUSIONS
  In conclusion, triiodothyronine administration to improve metabolic order and thus the function of organs for transplantation is not justified in brain-dead patients.
authors.affiliation: I Servizio di Anestesia e Rianimazione, Ospedali Riuniti, Bergamo.
authors.forename: V
authors.initials: V
authors.lastname: Gravame
authors.forename: L
authors.initials: L
authors.lastname: Porretti
authors.forename: M
authors.initials: M
authors.lastname: Cardillo
authors.forename: G
authors.initials: G
authors.lastname: Marchesi
authors.forename: M
authors.initials: M
authors.lastname: Rizzi
authors.forename: C
authors.initials: C
authors.lastname: Sacchi
authors.forename: A
authors.initials: A
authors.lastname: Candiani
authors.forename: M
authors.initials: M
authors.lastname: Chiaranda
authors.forename: L
authors.initials: L
authors.lastname: Gualandris
authors.forename: E
authors.initials: E
authors.lastname: Taioli
authors.forename: M
authors.initials: M
authors.lastname: Scalamogna
mesh_terms: D000293:Adolescent; D000328:Adult; D001926:Brain Death / Q000097:blood* / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007362:Intensive Care Units; D007558:Italy; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D006728:Hormones
vernacular_title: Alcune valutazioni ormonali nella morte cerebrale.