Aminoglycoside-RNA interactions.
The structural and physico-chemical parameters promoting the binding of aminoglycosides to RNAs are becoming clear. The strength of the interaction is dominated by electrostatics, with the positively charged aminoglycosides displacing metal ions. Although aminoglycosides inhibit most known ribozymes, aminoglycosides or polyamines are able to catalyze specific RNA cleavage in the absence of metal ions.
Walter
F
F
UPR 9002, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, F-67084, France.
Vicens
Q
Q
Westhof
E
E
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D012313:RNA / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D016337:RNA, Catalytic / Q000037:antagonists & inhibitors / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D016337:RNA, Catalytic; D012313:RNA