Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced reduction in hunger.
1. The authors studied the effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced changes in somatic and psychological perceptions of hunger state using a placebo-controlled, double-blind, Latin Square, cross-over design in 18 healthy volunteers. 2. D-methamphetamine significantly decreased these subjective ratings of hunger, presumably by increasing monoaminergic turnover. 3. Effects on hunger are hypothesized to be mediated by norepinephrine primarily, while dopamine plays only a modest role. Isradipine alone, an inhibitor of dopamine release, had no significant effect on the hunger measures. Additionally, isradipine pretreatment did not significantly alter d-methamphetamine's anorexic effects. 4. Isradipine may, therefore, not significantly modify the control of hunger in humans.
Johnson
B A
BA
Division of Alcohol and Drug Addiction, University of Texas, Health Science Center at San Antonio, USA. bjohnson@uthscsa.edu
Ait-Daoud
N
N
Bordnick
P S
PS
D000293:Adolescent; D000328:Adult; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D005260:Female; D006801:Humans; D006815:Hunger / Q000187:drug effects* / Q000502:physiology; D017275:Isradipine / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008875:Middle Aged
D002121:Calcium Channel Blockers; D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D017275:Isradipine