title: Synthesis of a novel series of imidazo[4,5-c]pyrazole derivatives and their evaluation as herbicidal agents.
abstract: Ever changing problems in agricultural weed control require periodic introduction of new herbicides. Imidazo[4,5-c]pyrazoles, which were considered of interest as potential herbicides, were synthesized and examined for the pre-emergence, post-emergence, and post-transplant control of weeds in rice against broadleaf and grass weed species. The data obtained suggest that some imidazo[4,5-c]pyrazoles have potential herbicidal activity against a wide range of weeds, with 5-methyl, 5-thiomethyl, and 5-unsubstituted derivatives being the most effective. No herbicidal activity was observed in the 5-methylsulfonylimidazo[4,5-c]pyrazole and imidazo[4,5-c]pyrazolone series.
authors.affiliation: Department of Pharmaceutical Science, University of Ferrara, Italy.
authors.forename: C B
authors.initials: CB
authors.lastname: Vicentini
authors.forename: M
authors.initials: M
authors.lastname: Manfrini
authors.forename: M
authors.initials: M
authors.lastname: Mazzanti
authors.forename: A
authors.initials: A
authors.lastname: Scatturin
authors.forename: C
authors.initials: C
authors.lastname: Romagnoli
authors.forename: D
authors.initials: D
authors.lastname: Mares
mesh_terms: D017360:Arabidopsis / Q000187:drug effects; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006109:Poaceae / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D006540:Herbicides; D011720:Pyrazoles