Alterations in spore production in Trichophyton rubrum treated in vitro with 1-amino-6-methyl-4-phenylpyrazolo[3,4-d]-1,2,3-triazole.
The effects of the newly synthesized triazole, 1-amino-6-methyl-4-phenylpyrazolo[3,4-d]-1,2,3-triazole (V5), on the dermatophyte Trichophyton rubrum were tested. Optical and electron microscopy showed that the treatment suppressed the various forms of saprophytic conidia, induced the formation of chlamydospores and accelerated the formation of arthroconidia. This new triazole did not reveal any fungistatic or fungicidal activity and could not be considered as an antifungal substance.
Mares
D
D
Department of Biology, University of Ferrara, Italy.
Romagnoli
C
C
Sacchetti
G
G
Vicentini
C B
CB
Bruni
A
A
D000935:Antifungal Agents / Q000494:pharmacology*; D008854:Microscopy, Electron; D013170:Spores / Q000648:ultrastructure; D014230:Triazoles / Q000494:pharmacology*; D014249:Trichophyton / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
D000935:Antifungal Agents; D014230:Triazoles