Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.
Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
Brown
M S
MS
Pfizer Central Research, Groton, CT 06340, USA.
Dirlam
J P
JP
McArthur
H A
HA
McCormick
E L
EL
Morse
B K
BK
Murphy
P A
PA
O'Connell
T N
TN
Pacey
M
M
Rescek
D M
DM
Ruddock
J
J
Wax
R G
RG
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D003521:Cyclopropanes / Q000378:metabolism; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016930:Saccharopolyspora / Q000235:genetics / Q000378:metabolism*
C401442:6-deoxy-13-cyclopropyl-erythromycin B; D000900:Anti-Bacterial Agents; D003521:Cyclopropanes; D018942:Macrolides; C015766:cyclopropanecarboxylic acid; D004917:Erythromycin; C064662:berythromycin