Bronchocentric granulomatosis as a first clinical manifestation in an adult patient with p67phox deficiency.
We report on a case of adult chronic granulomatous disease which first manifested as a pulmonary mass, and was histologically diagnosed as bronchocentric granulomatosis associated with aspergillosis in a patient with a deficiency of p67phox and a low oxidative response. Antifungal treatment was required for clinical resolution.
Barrot
E
E
Departments of Respiratory Diseases, University Hospital Virgen Rocío, Sevilla, Spain.
Ortega-Calvo
M
M
Borderas
F
F
Sanchez
J
J
Melero-Ruiz
J
J
Sanchez-Sanchez
B
B
D000328:Adult; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis* / Q000188:drug therapy; D001707:Biopsy, Needle; D001982:Bronchial Diseases / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D015769:Granuloma, Respiratory Tract / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D010750:Phosphoproteins / Q000172:deficiency*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D010750:Phosphoproteins; C079789:neutrophil cytosol factor 67K; D017964:Itraconazole