title: [The possibility of acute inflammatory reaction affects the development of pressure ulcers in bedridden elderly patients].
abstract: To test the hypothesis that acute inflammatory reaction associates with the development of pressure ulcers in bedridden elderly patients, 40 hospitalized elderly patients suffering from bacterial pneumonia, cerebrovascular disease, and femoral bone fracture were enrolled in this study. All of them were divided into two groups with pressure ulcers (group P; 17 patients) and without one (group N; 23 patients). The blood samples were taken from them within 5 days after the patients being bedridden. Although no significant difference exist in pressure ulcer risk factors (age, gender, Braden scale, underlying diseases, blood pressure, and heart rate) between the two groups, white blood cell, plasma C-reactive protein and fibrinogen in group P increased significantly as compared with those in group N. Besides number of platelets and maximum platelet aggregation rate were significantly higher in group P than in group N. Serum albumin and hemoglobin of both groups decreased after being bedridden, especially hemoglobin in group P was significantly lower than that in group N. While the concentration of serum IL-6 did not indicate a significant difference between both the groups, serum IL-1 beta increased significantly in group P. In conclusion, we suggested that acute inflammatory reaction releasing proinflammatory cytokines affected the development of pressure ulcer in bedridden elderly patients.
authors.affiliation: Department of Clinical Pathology, School of Medicine, Kitasato University, Sagamihara.
authors.forename: N
authors.initials: N
authors.lastname: Matsuyama
authors.forename: K
authors.initials: K
authors.lastname: Takano
authors.forename: T
authors.initials: T
authors.lastname: Mashiko
authors.forename: S
authors.initials: S
authors.lastname: Jimbo
authors.forename: N
authors.initials: N
authors.lastname: Shimetani
authors.forename: H
authors.initials: H
authors.lastname: Ohtani
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000097:blood; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications*; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D003668:Pressure Ulcer / Q000097:blood / Q000209:etiology*; D012709:Serum Albumin / Q000032:analysis
chemical_list: D016207:Cytokines; D012709:Serum Albumin; D005340:Fibrinogen; D002097:C-Reactive Protein