Elevated soluble E-selectin in cutaneous lupus erythematosus.
Elevated levels of soluble adhesion molecules (sCAMs); sE-Selectin, sICAM-1, and sVCAM-1 have been reported in various inflammatory and autoimmune diseases such as systemic lupus erythematosus (SLE), but not in cutaneous LE. 1.1.


METHODS
Sixty-nine serum samples from 51 LE patients, 24 with SLE, 19 with chronic cutaneous (DLE) and 8 with subacute cutaneous (SCLE) and sera from 32 controls were examined for sE-Selectin, sICAM-1 and sVCAM-1 using commercially available ELISA kits. Thirty serum samples from different time points were available from 12 LE patients. 1.2.


RESULTS
Significantly elevated levels of sE-Selectin were found in DLE patients with wide-spread lesions. In contrast, patients with SLE and SCLE did not have elevated levels of sE-Selectin but in concordance with earlier reports, sICAM-1 and sVCAM-1 were elevated in these patients. In serial samples it seemed that sE-Selectin correlated significantly with active cutaneous skin lesions while sICAM-1 remained elevated irrespective of disease activity. 1.3.


CONCLUSIONS
Since activated endothelial cells are the only source for sE-Selectin, our results suggest a more important role of endothelial cells in cutaneous LE than has previously been assumed. Further it might be speculated that selective inhibition of E-Selectin could have therapeutic implication in cutaneous LE.
Nyberg
F
F
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Stephansson
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D019040:E-Selectin / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008178:Lupus Erythematosus, Cutaneous / Q000145:classification / Q000175:diagnosis / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1