title: Increased expression of vascular endothelial growth factor in pyogenic granulomas.
abstract: The expression of vascular endothelial growth factor (VEGF) was analysed in biopsy samples from patients with pyogenic granuloma. The results disclosed the presence of a strong VEGF signal in pyogenic granulomas, which are constituted by a vast majority of cells of endothelial lineage. A marked positivity was evident in areas of proliferating endothelial cells without vessel lumen formation. In the same respect, staining for VEGF was less marked in the vessels with a well-developed lumen. The fact that VEGF production appears to be limited to endothelial cell precursors or immature endothelial cells prior to the complete development of the vessels, leads to the possibility that VEGF may act as an autocrine factor in circumstances of endothelial cell stimulation.
authors.affiliation: Department of Immunology, Fundación Jiménez Díaz, University of Autonomy, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Bragado
authors.forename: E
authors.initials: E
authors.lastname: Bello
authors.forename: L
authors.initials: L
authors.lastname: Requena
authors.forename: G
authors.initials: G
authors.lastname: Renedo
authors.forename: E
authors.initials: E
authors.lastname: Texeiro
authors.forename: M V
authors.initials: MV
authors.lastname: Alvarez
authors.forename: M A
authors.initials: MA
authors.lastname: Castilla
authors.forename: C
authors.initials: C
authors.lastname: Caramelo
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D016228:Endothelial Growth Factors / Q000032:analysis*; D005260:Female; D017789:Granuloma, Pyogenic / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012680:Sensitivity and Specificity; D012871:Skin Diseases / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D015415:Biomarkers; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors