Analgesic activity of thioureido derivatives of arylsemicarbazones.
The synthesis of a series of novel arylsemicarbazones derived from 4-aminoacetophenone and their evaluation for analgesic activity are described. The p-chloro-substituted derivatives (12-15) are extremely potent compounds as compared to standard drugs currently being used.
Mishra
V
V
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India.
Pandeya
S N
SN
Singh
P N
PN
Rupainwar
D C
DC
D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D010147:Pain Measurement / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012664:Semicarbazones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D012664:Semicarbazones; D013890:Thiourea