The effect of G-CSF on the composition of human bone marrow.
The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10-13). Assessment of aspirates revealed an increase in the myeloid to erythroid (M : E) ratio (P = 0.00006), the proportion of myeloid cells (P < 10-8), myelocytes (P = 0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.
Tegg
E M
EM
Clinical Haematology and Medical Oncology Unit, Royal Hobart Hospital, Tasmania, Australia.
Tuck
D M
DM
Lowenthal
R M
RM
Marsden
K A
KA
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D019070:Cell Lineage / Q000187:drug effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000166:cytology / Q000187:drug effects; D008875:Middle Aged; D012189:Retrospective Studies
D016179:Granulocyte Colony-Stimulating Factor