5-HT1A autoreceptor desensitization by chronic ultramild stress in mice.
Electrophysiological and biochemical approaches were used to assess possible changes in central 5-HT neurotransmission in mice that had been subjected to chronic ultramild stress for 8 weeks. This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. These data demonstrate that chronic ultramild stress triggers a long term and durable functional desensitization of somatodendritic 5-HT1A autoreceptors in mice.
Lanfumey
L
L
INSERM U 288, CHU Pitié-Salpêtrière, Paris, France.
Pardon
M C
MC
Laaris
N
N
Joubert
C
C
Hanoun
N
N
Hamon
M
M
Cohen-Salmon
C
C
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002908:Chronic Disease; D003345:Corticosterone / Q000378:metabolism; D004594:Electrophysiology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D011743:Pyrimidines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013315:Stress, Psychological / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology
D011743:Pyrimidines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C043077:ipsapirone; D003345:Corticosterone