title: Gram-negative bacterial sepsis and the sepsis syndrome.
abstract: Gram-negative sepsis syndrome is an increasingly common complication in medical and surgical patients. The molecular and cellular mechanisms underlying this dreaded complication are yielding to investigation. These studies have led to a multiplicity of targets for novel therapies. Despite highly promising results in many animal studies, clinical studies have been disappointing.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, USA.
authors.forename: V
authors.initials: V
authors.lastname: Lazaron
authors.forename: R A
authors.initials: RA
authors.lastname: Barke
mesh_terms: D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy*; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000378:metabolism / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy*