title: Phylogenic analysis of echovirus type 30 isolated from a large epidemic of aseptic meningitis in Japan during 1997-1998.
abstract: During 1997 to 1998, a nationwide epidemic of aseptic meningitis occurred in Japan. More than 4,500 isolates from patients with aseptic meningitis were identified as echovirus type 30. To investigate the character of these isolates, we examined the nucleotide sequences of thirty-seven geographical representatives and compared them with 50 strains isolated during the past 20 years. The phylogenic analysis used partial sequences from either the VP1 or VP4-VP2 region of the viral capsid. This analysis revealed that the isolates were divided into six genomic groups. All isolates identified during 1997-1998 belonged to only two genomic groups; these two groups are thought to be the causative viral agents involved in the recent epidemic.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. hyoshida@nih.go.jp
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: Z
authors.initials: Z
authors.lastname: Hong
authors.forename: T
authors.initials: T
authors.lastname: Yoneyama
authors.forename: K
authors.initials: K
authors.lastname: Yoshii
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Ota
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Iritani
authors.forename: M
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: S
authors.initials: S
authors.lastname: Takao
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Yamanishi
authors.forename: M
authors.initials: M
authors.lastname: Hamazaki
authors.forename: S
authors.initials: S
authors.lastname: Yoshino
authors.forename: M
authors.initials: M
authors.lastname: Oseto
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Hamano
authors.forename: K
authors.initials: K
authors.lastname: Sakae
authors.forename: H
authors.initials: H
authors.lastname: Tsuzuki
authors.forename: S
authors.initials: S
authors.lastname: Chiya
authors.forename: H
authors.initials: H
authors.lastname: Onishi
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: T
authors.initials: T
authors.lastname: Munemura
authors.forename: A
authors.initials: A
authors.lastname: Kawamoto
authors.forename: T
authors.initials: T
authors.lastname: Miyamura
mesh_terms: D029822:Enterovirus B, Human / Q000145:classification* / Q000302:isolation & purification*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008582:Meningitis, Aseptic / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny