title: Resolution of fetal goiter after discontinuation of propylthiouracil in a pregnant woman with Graves' hyperthyroidism.
abstract: We report a case of Graves' hyperthyroidism in a 34-year-old pregnant woman treated with propylthiouracil (PTU) complicated by the development of a fetal goiter. Because of the fetal goiter and normal maternal thyroid function tests, the PTU was discontinued. Over the next 10 weeks, there was a progressive decrease in the fetal thyroid volume as documented by ultrasonography. The fetal neck returned to a normal flexed position, fetal growth and amniotic fluid remained normal, and the patient remained asymptomatic. A normal infant was delivered at term. This is the first report to demonstrate that noninvasive management may be appropriate for fetuses with goiter caused by antithyroid drug therapy.
authors.affiliation: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Ochoa-Maya
authors.forename: M C
authors.initials: MC
authors.lastname: Frates
authors.forename: A
authors.initials: A
authors.lastname: Lee-Parritz
authors.forename: E W
authors.initials: EW
authors.lastname: Seely
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000628:therapy; D006042:Goiter / Q000139:chemically induced* / Q000628:therapy; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011441:Propylthiouracil / Q000009:adverse effects*
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil