Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation.
Zerumbone was isolated from the rhizomes of Zingiber zerumbet Smith as a potent inhibitor of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. The IC50 value of zerumbone (0.14 microM) is noticeably lower than those of the anti-tumor promoters we have hitherto obtained. Interestingly, alpha-humulene lacking the carbonyl group at the 8-position in zerumbone was inactive (IC50 > 100 microM), while 8-hydroxy-alpha-humulune was markedly active (IC50 = 0.95 microM).
Murakami
A
A
Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan.
Takahashi
M
M
Jiwajinda
S
S
Koshimizu
K
K
Ohigashi
H
H
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D000081222:Monocyclic Sesquiterpenes; D010936:Plant Extracts; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects*; D019862:Zingiberales / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D000081222:Monocyclic Sesquiterpenes; D010936:Plant Extracts; D012717:Sesquiterpenes; C403304:zerumbone; C042686:humulene; D013755:Tetradecanoylphorbol Acetate