Percutaneous transport of diclofenac sodium from mixtures of fatty alcohol (or fatty acid) and propylene glycol through the rabbit abdominal skin.
Diclofenac sodium is a nonsteroidal anti-inflammatory drug with analgesic, antipyretic, and anti-inflammatory activity. When used in a topical application, diclofenac can diffuse through the skin and into the subcutaneous tissue to effect the anti-inflammatory action. In this study, in vitro evaluations of the percutaneous transport of diclofenac sodium in various bases containing fatty alcohols/propylene glycol or fatty acid/propylene glycol mixtures through the abdominal skin of the rabbit were investigated. Results show that the transdermal flux of diclofenac sodium in the fatty alcohol/propylene glycol bases of the same ratio is affected by the chain length of the fatty alcohol, and its effect is in the order of C10 > C12 > C14 > C18. However, the transdermal flux of diclofenac sodium in the fatty acid/propylene glycol bases of the same ratio is also affected by the chain length of the fatty acid, but no absolute relationship was found. For the same chain length of fatty acid and fatty alcohol used in the formulation base that was otherwise the same, the transdermal flux of diclofenac sodium is higher in the formula containing fatty alcohol than that containing fatty acid.
Wong
C Y
CY
Department of Orthopaedics, Kaohsiung Veterans General Hospital, Taiwan, R.O.C.
Guu
Y B
YB
Wang
M T
MT
Wang
D P
DP
D000005:Abdomen; D000279:Administration, Cutaneous; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D004008:Diclofenac / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005227:Fatty Acids; D005233:Fatty Alcohols; D066298:In Vitro Techniques; D009823:Ointment Bases; D011409:Propylene Glycols; D011817:Rabbits; D012869:Skin Absorption / Q000502:physiology*; D013256:Steroids
D000893:Anti-Inflammatory Agents; D005227:Fatty Acids; D005233:Fatty Alcohols; D009823:Ointment Bases; D011409:Propylene Glycols; D013256:Steroids; D004008:Diclofenac