The nucleotide sequence of the high-leukemogenic murine retrovirus SL3-3 reveals a patch of mink cell focus forming-like sequences upstream of the ecotropic envelope gene. Brief report.
We report the complete nucleotide sequence of the potent T-lymphomagenic murine retrovirus SL3-3. The non-LTR regions of the virus show 98% sequence identity to the endogenous ecotropic Akv murine leukemia virus. While the region encoding the surface envelope protein is completely identical to that of Akv, a approximately 200 nucleotide stretch in the integrase encoding region upstream of env is similar to the sequence of mink cell focus forming (MCF) viruses and shows a complete match with the mouse retrovirus 10A1. The history of SL3-3 may therefore include recombination involving an Akv-like virus and a virus with MCF-like sequences.
Lund
A H
AH
Department of Molecular and Structural Biology, University of Aarhus, Aarhus, Denmark.
Pedersen
F S
FS
D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral; D015752:Genes, env; D009052:Leukemia Virus, Murine / Q000235:genetics*; D051379:Mice; D008908:Mink Cell Focus-Inducing Viruses / Q000235:genetics*; D008969:Molecular Sequence Data
D004279:DNA, Viral