title: Antiinflammatory activity of adrenomedullin in the acetic acid peritonitis in rats.
abstract: The antiinflammatory effect of ADM was studied in different models of inflammation and compared to the one of CGRP. Peptides were active against acetic acid-induced peritonitis in the rats. ADM and CGRP exerted the antiinflammatory effect at different doses, 400 and 20 ng/kg respectively, but with different efficacy (ADM >CGRP). This effect was blocked by pretreatment with CGRP (8-37) fragment or with L-NAME. No antiinflammatory activity was evidenced against serotonin- or carrageenin-induced rat paw edema. Our data suggest that ADM exerts antiinflammatory activity in the model characterized by a vascular component. This effect involves CGRP receptors and appears to be mediated by nitric oxide system.
authors.affiliation: Institute of Pharmacology, University of Catania, School of Medicine, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Clementi
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: V M
authors.initials: VM
authors.lastname: Cutuli
authors.forename: A
authors.initials: A
authors.lastname: Prato
authors.forename: N G
authors.initials: NG
authors.lastname: Mangano
authors.forename: M
authors.initials: M
authors.lastname: Amico-Roxas
mesh_terms: D019342:Acetic Acid; D053607:Adrenomedullin; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D010455:Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004791:Enzyme Inhibitors; D010455:Peptides; D053607:Adrenomedullin; D015740:Calcitonin Gene-Related Peptide; D019342:Acetic Acid; D019331:NG-Nitroarginine Methyl Ester