title: Progression into and out of mitosis.
abstract: Progression through mitosis is controlled by cyclin-dependent kinases, which drive cells into metaphase, and by the anaphase-promoting complex/cyclosome, a ubiquitin ligase that triggers sister chromatid separation and exit from mitosis. Recent work has shown how the mutual regulation between cyclin-dependent kinases and the anaphase-promoting complex/cyclosome ensures that cell-cycle events occur in the right order. The analysis of complexes required for sister chromatid cohesion and chromosome condensation has revealed how cyclin-dependent kinases and the anaphase-promoting complex/cyclosome control the behaviour of chromosomes.
authors.affiliation: c/o EMBL, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden, Heidelberg, D-69117, Germany. Zacharia@EMBL-Heidelberg.de.
authors.forename: W
authors.initials: W
authors.lastname: Zachariae
mesh_terms: D000705:Anaphase; D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D002455:Cell Division; D002842:Chromatids / Q000502:physiology; D002875:Chromosomes / Q000502:physiology*; D005800:Genes, Fungal / Q000235:genetics; D008938:Mitosis; D017027:Protein Tyrosine Phosphatases; D029701:Saccharomyces cerevisiae Proteins; D014981:Xenopus
chemical_list: C074860:CDC14 protein, S cerevisiae; D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D017027:Protein Tyrosine Phosphatases