[Quantitative and cytomorphometric analysis of glial population in the frontal cortex of contralaterally lesioned rats].
BACKGROUND
In the last years, the changes in glial cells during different alterations in the Central Nervous System have been studied. It is known that astrocytes and microglial cells are the glial cells which present the major reactivity.


OBJECTIVE
The aim of this work was to analyze the glial cell changes induced by a lesion.


METHODS
We studied the quantitative and morphometric changes observed in glial cells in the different layers of contralateral frontal cortex using micrometric techniques and image analysis.


RESULTS
In contralateral side to the lesions, we observed an increase in the total glial cells in all the cortical layers. The astrocytes only increased their number in cortical layer I, but microglia and oligodendrocytes increased in all the layers. In the cytomorphometric analysis an increase in the nucleus area of astrocytes was observed.


CONCLUSIONS
The glial cell response to the lesions is different for astrocytes, microglia and oligodendrocytes but these changes affected to all the cortical layers.
Ramírez-Expósito
M J
MJ
Facultad de Ciencias Experimentales, Universidad de Jaén, España. mramirez@ujaen.es
Martínez-Martos
J M
JM
D000818:Animals; D001253:Astrocytes / Q000473:pathology*; D002452:Cell Count; D005625:Frontal Lobe / Q000473:pathology*; D008297:Male; D009836:Oligodendroglia / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
Análisis cuantitativo y citomorfométrico de la población glial en la corteza frontal de ratas con lesiones contralaterales.