Effect of oral administration of dotarizine on cerebrovasculature subjected to constriction followed by dilatation in rabbits.
In the study presented the effect of Dotarizine on blood flow velocity in cerebral arteries - in middle cerebral artery (MCA), and basilar artery (BA)- was investigated and compared utilising transcranial Doppler sonography during normoventilation, 15 min hyperventilation with subsequent 3 min anoxia in anaesthetized rabbits. In the Dotarizine treated group (12 rabbits) 25 mg/kg of Dotarizine dissolved in 0,25% agar was administered orally for five days twice daily. In the control group (9 rabbits) animals were fed with agar of the same concentration. The results revealed that decrease of flow velocity caused by hyperventilation and increase during anoxia were less pronounced in the Dotarizine treated group than in control group of animals. A difference between changes of flow velocity in MCA and BA during anoxia was found and the different reactivity of both vessels was established.
Jarus-Dziedzic
K
K
Department of Neurosurgery, Medical Research Centre, Polish Academy of Science, Warsaw, Poland.
Czernicki
Z
Z
Cervos-Navarro
J
J
Jurkiewicz
J
J
D000284:Administration, Oral; D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D002534:Hypoxia, Brain / Q000503:physiopathology; D008297:Male; D020768:Middle Cerebral Artery / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits; D017585:Ultrasonography, Doppler, Transcranial / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*
D001559:Benzhydryl Compounds; D002121:Calcium Channel Blockers; D010879:Piperazines; C083946:dotarizine