Anaerobic glycolysis. The metabolism of the preovulatory human oocyte.
OBJECTIVE
The aim of the study was to investigate the process of glycolysis in gonadotropic, hyperstimulated, human ovarian follicles.


METHODS
Follicular fluid (FF) lactate and glucose concentrations were measured in 26 patients with tubal factor infertility undergoing in vitro fertilization treatment.


RESULTS
The mean FF lactate and glucose concentrations were 3.17+/-0.90 mM with positive, and 3.39+/-0.91 mM with negative correlations to follicular size. FF lactate concentration correlated negatively to glucose levels.


CONCLUSIONS
Our study confirms in vivo the anaerobic glycolysis in gonadotropic, hyperstimulated human ovarian follicles.
Gull
I
I
Sara Racine In-Vitro Fertilization Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Israel.
Geva
E
E
Lerner-Geva
L
L
Lessing
J B
JB
Wolman
I
I
Amit
A
A
D000693:Anaerobiosis; D002064:Buserelin / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005184:Fallopian Tube Diseases / Q000150:complications; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D015571:Follicular Fluid / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D006019:Glycolysis; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D019344:Lactic Acid / Q000032:analysis; D007986:Luteinizing Hormone / Q000008:administration & dosage; D008596:Menotropins / Q000008:administration & dosage; D009865:Oocytes / Q000378:metabolism*; D006080:Ovarian Follicle / Q000033:anatomy & histology; D010060:Ovulation; D011446:Prospective Studies
D006063:Chorionic Gonadotropin; D019344:Lactic Acid; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005947:Glucose; D002064:Buserelin