title: WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction.
abstract: The WIT (What Is There) (http://wit.mcs.anl.gov/WIT2/) system has been designed to support comparative analysis of sequenced genomes and to generate metabolic reconstructions based on chromosomal sequences and metabolic modules from the EMP/MPW family of databases. This system contains data derived from about 40 completed or nearly completed genomes. Sequence homologies, various ORF-clustering algorithms, relative gene positions on the chromosome and placement of gene products in metabolic pathways (metabolic reconstruction) can be used for the assignment of gene functions and for development of overviews of genomes within WIT. The integration of a large number of phylogenetically diverse genomes in WIT facilitates the understanding of the physiology of different organisms.
authors.affiliation: Integrated Genomics Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. ross@integratedgenomics.com
authors.forename: R
authors.initials: R
authors.lastname: Overbeek
authors.forename: N
authors.initials: N
authors.lastname: Larsen
authors.forename: G D
authors.initials: GD
authors.lastname: Pusch
authors.forename: M
authors.initials: M
authors.lastname: D'Souza
authors.forename: E
authors.initials: E
authors.lastname: Selkov
authors.forename: N
authors.initials: N
authors.lastname: Kyrpides
authors.forename: M
authors.initials: M
authors.lastname: Fonstein
authors.forename: N
authors.initials: N
authors.lastname: Maltsev
authors.forename: E
authors.initials: E
authors.lastname: Selkov
mesh_terms: D016208:Databases, Factual; D016678:Genome; D020407:Internet; D016366:Open Reading Frames; D018511:Systems Integration