Insight into regulatory factor targeting to transcriptionally active subnuclear sites.
Mechanisms that coordinate the spatial organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture contribute to the sorting of regulatory information as well as the assembly and activity of sites within the nucleus that support gene expression. In this article we will present an overview of experimental approaches that provide insight into the trafficking of the hematopoietic and bone-specific AML/CBF family of regulatory factors to transcriptionally active subnuclear sites.
Stein
G S
GS
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts, 01655, USA. gary.stein@umassmed.edu
van Wijnen
A J
AJ
Stein
J L
JL
Lian
J B
JB
Javed
A
A
McNeil
S
S
Pockwinse
S M
SM
D001692:Biological Transport; D001846:Bone Development; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006410:Hematopoiesis; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D014157:Transcription Factors