title: Peripheral membrane proteins: FYVE sticky fingers.
abstract: The recently determined structure of the lipid-binding 'FYVE' domain provides several clues to the mode of interaction for this class of peripheral membrane proteins. However, the application of traditional modes of structural analysis to diffusible membrane-binding proteins exposes some limitations of these techniques.
authors.affiliation: Department of Biochemistry, University College London, Ludwig Institute for Cancer Research, London, WC1E 6BT, W1P 8BT, UK. driscoll@biochem.ucl.ac.uk
authors.forename: P C
authors.initials: PC
authors.lastname: Driscoll
authors.forename: A L
authors.initials: AL
authors.lastname: Vuidepot
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D006801:Humans; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008823:Micelles; D008958:Models, Molecular; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D046911:Macromolecular Substances; D008563:Membrane Lipids; D008565:Membrane Proteins; D008823:Micelles; D010716:Phosphatidylinositols