The biology of chronically denervated Schwann cells.
This paper is divided into two sections, both concerned with the effects of chronic denervation on Schwann cells. The first group of experiments explore the proposal that lengthy denervation produces changes in Schwann cells in vivo that compromise axonal regeneration. The second group of experiments compare the molecular phenotypes of acutely and chronically denervated Schwann cells in vitro, and examine their responses to an exogenously applied neuregulin.
Hall
S M
SM
Division of Anatomy, Cell and Human Biology, Guy's Thomas' School of Medicine, London, United Kingdom. susan.standring@kcl.ac.uk
D000818:Animals; D001369:Axons / Q000502:physiology; D003714:Denervation; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology; D009416:Nerve Regeneration; D012583:Schwann Cells / Q000166:cytology / Q000502:physiology*
D009414:Nerve Growth Factors