[Determination of interleukin-6 messenger RNA as malignant progression index in monoclonal gammapathy of undetermined significance].
The monoclonal gammopathy of undetermined significance (MGUS) could be considered a preneoplastic condition since no clinical and laboratory features are able to identify in advance the patients at high risk of disease progression. In this study we analysed IL-6mRNA expression on both bone marrow mononuclear cells and peripheral blood mononuclear cells sample of multiple myeloma (MM) and MGUS patients for evaluation if IL-6mRNA expression could be considered diagnostic or prognostic aspect of progression disease risk to MM. We concluded that expression of IL-6mRNA hasn't prognostic significance for the progression disease risk to multiple myeloma but could have a discriminant significance the MM and MGUS pathologies when combined with gene rearrangements and immunochemicals analysis.
Mancini
R
R
Centro Nazionale Trasfusione Sangue, Croce Rossa Italiana, Roma.
Palange
M
M
Dionisi
M G
MG
De Angelis
V
V
Matteocci
A
A
Strano
L
L
D015152:Blotting, Northern; D015870:Gene Expression; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics; D010265:Paraproteinemias / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D012307:Risk Factors
D015850:Interleukin-6; D012333:RNA, Messenger
La misura di RNA messaggero dell'interleuchina-6 quale indice di progressione maligna della gammapatia monoclonale di significato incerto.