Increased levels of tau-like protein in patients with Down syndrome.
Tau-like protein levels from 40 Down syndrome (DS) persons (31-70 years old), 40 non-DS age-matched normal controls, 18 non-DS mentally retarded (MR) persons (26-91 years old), 25 probable Alzheimer disease (AD) patients (55-99 years old) and 24 non-demented elderly controls (54-79 years old) were measured using a sandwich enzyme linked immunosorbent assay. The levels were detected in 22 of 40 DS persons and were significantly higher in DS than any other group (P < 0.0001). There was no relationship between tau-like protein levels and age, gender or apolipoprotein E phenotypes in any of the five groups.
Mehta
P D
PD
Department of Immunology, Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314-6399, USA. pdmehta@worldnet.att.net
Patrick
B A
BA
Dalton
A J
AJ
Aisen
P S
PS
Emmerling
M E
ME
Sersen
E A
EA
Wisniewski
H M
HM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood; D004314:Down Syndrome / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000097:blood; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D016875:tau Proteins / Q000097:blood*
D016875:tau Proteins