Distribution of beta-lactamases in actinomycetes.
The distribution of beta-lactamase activities in a collection of actinomycete strains was surveyed. Six of 127 strains were found to produce beta-lactamase. This low frequency was in contrast to the case with Streptomyces species. The producing strains were not related phylogenetically. MICs of benzylpenicillin did not correlate with beta-lactamase production.
Ogawara
H
H
Department of Biochemistry, Meiji Pharmaceutical University, Tokyo 204-8588, Japan. hogawara@my-pharm.ac.jp
Kawamura
N
N
Kudo
T
T
Suzuki
K I
KI
Nakase
T
T
D000192:Actinomycetales / Q000187:drug effects / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D010802:Phylogeny; D013997:Time Factors; D001618:beta-Lactamases / Q000378:metabolism*
D010406:Penicillins; D001618:beta-Lactamases; D010400:Penicillin G