title: Silent functional magnetic resonance imaging demonstrates focal activation in rapid eye movement sleep.
abstract: Functional imaging of human sleep has been performed with nuclear medicine methods, but MRI has been difficult to implement, in part because of the noise associated with echo-planar imaging as well as the difficulty in reading physiologic signals in the MRI environment. We describe a silent MR sequence that can record brain activation over many hours with simultaneous acquisition of an EEG. This shows activation of occipital cortex and deactivation of frontal cortex during REM sleep, in agreement with previous studies using other techniques. MRI-Sleep-REM sleep.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. loevk@insel.ch
authors.forename: K O
authors.initials: KO
authors.lastname: Lövblad
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: P M
authors.initials: PM
authors.lastname: Jakob
authors.forename: T
authors.initials: T
authors.lastname: Scammell
authors.forename: C
authors.initials: C
authors.lastname: Bassetti
authors.forename: M
authors.initials: M
authors.lastname: Griswold
authors.forename: J
authors.initials: J
authors.lastname: Ives
authors.forename: J
authors.initials: J
authors.lastname: Matheson
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
authors.forename: S
authors.initials: S
authors.lastname: Warach
mesh_terms: D000328:Adult; D001931:Brain Mapping; D017352:Echo-Planar Imaging / Q000295:instrumentation; D004867:Equipment Design; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009778:Occipital Lobe / Q000502:physiology*; D017286:Polysomnography / Q000295:instrumentation*; D012016:Reference Values; D012895:Sleep, REM / Q000502:physiology*