[Strong connection between malnutrition, inflammation and arteriosclerosis. Improved treatment of renal failure if underlying factors are attacked].
Malnutrition, inflammation and atherosclerotic cardiovascular disease occur at high prevalence, and often concomitantly, in conjunction with chronic renal failure. Several features of malnutrition (e.g., increased oxidative stress, increased plasma levels of fibrinogen, Lp(a), and inflammation) may all, alone or in concert, increase the risk of cardiovascular disease. Recent findings suggest malnutrition and hypoalbuminaemia in chronic renal failure to be largely the consequence of such factors as heart failure, chronic infection and inflammation, that simultaneously trigger the development of atherosclerotic cardiovascular disease. Central to this scenario is the involvement of proinflammatory cytokines which may cause muscle wasting, hypoalbuminaemia, anorexia, and accelerated atherosclerosis. It is unlikely that the high mortality due to atherosclerotic disease among patients with chronic renal failure can be substantially reduced unless new treatment strategies are developed which address the complex relationships that exist between malnutrition, inflammation and cardiovascular disease.
Efendic
E
E
Karolinska institutet, Stockholm.
Lindholm
B
B
Bergström
J
J
Stenvinkel
P
P
D001161:Arteriosclerosis / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D002097:C-Reactive Protein / Q000032:analysis; D016207:Cytokines / Q000032:analysis; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D009748:Nutrition Disorders / Q000150:complications / Q000209:etiology* / Q000517:prevention & control; D006435:Renal Dialysis / Q000009:adverse effects; D012307:Risk Factors
D016207:Cytokines; D002097:C-Reactive Protein
Starka samband mellan malnutrition, inflammation och arterioskleros. Bättre behandling av njursvikt om faktorerna bakom angrips.