The kelch repeat superfamily of proteins: propellers of cell function.
The kelch motif was discovered as a sixfold tandem element in the sequence of the Drosophila kelch ORF1 protein. The repeated kelch motifs predict a conserved tertiary structure, a beta-propeller. This module appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this growing superfamily are present throughout the cell and extracellularly and have diverse activities. In this review, we discuss current information concerning the structural organization of kelch repeat proteins, their biological roles and the molecular basis of their action.
Adams
J
J
MRC-LMCB and Dept of Biochemistry and Molecular Biology, University College London, Gower Street, London UK.
Kelso
R
R
Cooley
L
L
D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012091:Repetitive Sequences, Nucleic Acid; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D029721:Drosophila Proteins; C117553:I-element-gag protein, Drosophila; D019476:Insect Proteins