title: Increased intensity of lung infiltrates at the side of lung cancer in patients with lung cancer associated with pulmonary fibrosis.
abstract: It has been reported that lung cancer is frequently associated with idiopathic pulmonary fibrosis (IPF). The purpose of this study was to compare the intensity of lung infiltrates between the side associated with lung cancer and the side without lung cancer. Twenty-three patients (24 lung cancers) with primary lung cancer associated with pulmonary fibrosis were retrospectively evaluated. Chest CT findings were evaluated by three expert radiologists using the intensity scores. In 16 of the 23 patients, it was possible to compare the intensity of lung infiltrates between both sides of the lungs. As a result, increased intensity at the side in which lung cancer developed was demonstrated in 12 of 16 patients (75%). In the remaining four patients, intensity of lung infiltrates was the same in both lungs. In operated patients as well as autopsied patients, it was possible to evaluate the pathological findings of lung tissues around cancer cells. This study clearly demonstrates that the intensity of lung infiltrates increased at the side in which lung cancer developed.
authors.affiliation: First Department of Internal Medicine, Kagawa Medical University, Kita-gun, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Fujita
authors.forename: I
authors.initials: I
authors.lastname: Yamadori
authors.forename: H
authors.initials: H
authors.lastname: Namihira
authors.forename: I
authors.initials: I
authors.lastname: Suemitsu
authors.forename: S
authors.initials: S
authors.lastname: Bandoh
authors.forename: Y
authors.initials: Y
authors.lastname: Fukunaga
authors.forename: S
authors.initials: S
authors.lastname: Hojo
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: N
authors.initials: N
authors.lastname: Dobashi
authors.forename: K
authors.initials: K
authors.lastname: Dohmoto
authors.forename: J
authors.initials: J
authors.lastname: Takahara
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000150:complications*; D014057:Tomography, X-Ray Computed