Stobadine: bellwether of a broader view of drug actions.
Stobadine was recognized early in its development as having antioxidant properties. A number of laboratories found associations between the antioxidant properties of stobadine and its potential beneficial effects. We found that stobadine acted as an antioxidant in a modification of an oxygen radical absorbance capacity (ORAC) assay. Similar results were observed with other drugs, including tirilazad and pramipexole. We suggest that stobadine and certain other drugs exhibit antioxidant properties in both hydrophilic and hydrophobic environments. Other drugs have been developed for their antioxidant properties and some currently marketed drugs have antioxidant properties. Although they may not have been explicitly sought during development, at least some of the beneficial effects may be related to antioxidant properties and/or scavenging of free radicals. Because stobadine was one of the first drugs for which useful properties were associated with its antioxidant actions, stobadine may be seen as a bellwether of a broader view of pharmacological actions--a view that encompasses antioxidant properties as a useful basis of therapeutic effects.
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Department of Pharmacology, University of Washington, Seattle 98195-7280, USA. vincenzi@u.washington.edu
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D000975:Antioxidants / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D010799:Phycoerythrin / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000975:Antioxidants; D002243:Carbolines; D016166:Free Radical Scavengers; D014867:Water; D010799:Phycoerythrin; C100106:dicarbine