A comparative study of Embelia schiperi and Embelia keniensis on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.
Intraperitoneal administration of the methanol extract of Embelia schiperi (ES) to normal mice caused a significant decrease in blood glucose (p < 0.01) and a significant increase in triglycerides 4 hours after administration at 100 mg/kg (p < 0.01). The toluene fraction of Embelia keniensis methanol extract (TS) showed hypoglycemic and lipid lowering activity 7 hours after intraperitoneal administration at 100 mg/kg. In addition, TS (100 mg/kg) administration significantly decreased blood glucose in epinephrine-induced hyperglycemic mice (p < 0.01). Moreover, ES tended to increase while TS tended to decrease the blood triglycerides in epinephrine-induced hyperglycemic mice. On the other hand, no changes in blood cholesterol were observed after the administration of ES or TS in normal and epinephrine-induced hyperglycemic mice. We found that two species from Embelia, ES and TS, have different activities on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.
Kato
A
A
Kobe Pharmaceutical University, Hyogo, Japan.
Miura
T
T
Nishiyama
Y
Y
Tachibana
Y
Y
Ohnishi
Y
Y
Mathenge
S G
SG
Albert
R
R
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004837:Epinephrine; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D010946:Plants, Medicinal; D013566:Sympathomimetics; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D010936:Plant Extracts; D013566:Sympathomimetics; D014280:Triglycerides; D002784:Cholesterol; D004837:Epinephrine