The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling.
This review describes the main properties of a new family of cytokine-inducible proteins which interfere with the Jak/Stat transduction pathway and negatively regulate the duration of cytokine-induced signal activation. These proteins act not only as negative feedback regulators but also inhibit response to cytokines different from those used to induce their expression. These proteins are potentially important regulators of inflammatory and immune responses of hematopoiesis and hormone response.
Gisselbrecht
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INSERM U. 363, ICGM, Paris V, Hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris. gisselbrecht@cochin.inserm.fr
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000378:metabolism; D000075065:Elongin; D006801:Humans; D017874:Immediate-Early Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008894:Milk Proteins; D017434:Protein Structure, Tertiary / Q000502:physiology; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000187:drug effects*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D015854:Up-Regulation
D002352:Carrier Proteins; D016207:Cytokines; D004268:DNA-Binding Proteins; D000075065:Elongin; D017874:Immediate-Early Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008894:Milk Proteins; D011506:Proteins; D012097:Repressor Proteins; D050799:STAT5 Transcription Factor; D000071222:Suppressor of Cytokine Signaling 1 Protein; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C108944:SOCS1 protein, human; C106644:SOCS3 protein, human