Novel highly oxygenated bisabolane sesquiterpenes from Cremanthodium discoideum.
Five new highly oxygenated bisabolane sesquiterpenes (1-5) were isolated from Cremanthodium discoideum. Their structures were elucidated on the basis of spectroscopic analysis and chemical transformations. The structure and relative stereochemistry of 1 were determined by single-crystal X-ray crystallography on the acetate derivative, 1a. Compound 1 showed antibacterial activity against Bacillus acidilatici and Bacillus subtilis.
Zhu
Y
Y
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Chemistry and Chemical Engineering College, Lanzhou University, Lanzhou 730000, People's Republic of China.
Yang
L
L
Jia
Z J
ZJ
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001407:Bacillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D012717:Sesquiterpenes