title: Cerebrovascular metabolic autoregulation is impaired during liver transplantation.
abstract: BACKGROUND
  We determined whether the coupling between cerebral blood flow (CBF) and oxygen metabolism (CMRO2) is preserved during liver transplantation. Because of cerebrovascular dilatation, we hypothesized that cerebral metabolic autoregulation is impaired, because CBF becomes uncoupled from CMRO2 during the reperfusion phase of the operation.
  
  
  METHODS
  In a prospective study, 13 patients (8 women, median age 46, range 21-6) with liver failure (10 with end-stage chronic liver disease and 3 with acute liver failure) were enrolled. Catheters were placed in a femoral artery and in the internal jugular vein for calculation of the cerebral arteriovenous oxygen content difference (AVDO2). CBF was recorded by the 133Xenon injection technique, and by transcranial Doppler sonography determined mean flow velocity (Vmean) in the middle cerebral artery. The CMRO2 was calculated as the AVDO2 times CBF and the cerebrovascular resistance (CVR) as the mean arterial pressure to CBF ratio. An index of large cerebral artery diameter was expressed by the CBF to Vmean ratio.
  
  
  RESULTS
  From induction of anesthesia to the anhepatic period, CBF decreased from a median of 47 (interquartiles 31-55) to 41 (37-48) ml 100 g(-1) min(-1), whereas the CMRO2 remained unchanged (1.3 [0.9-2.5] vs. 1.7 [0.9-2.3] ml 100 g(-1) min(-1)). In the reperfusion phase, the CBF increased to 51 (45-54) ml 100 g(-1) min(-1), whereas the CMRO2 remained unchanged at 1.1 (1.0-2.5) ml 100 g(-1) min(-1). The CVR decreased from 2.0 mm Hg (1.4-2.1) to 1.4 (1.1-1.8) mm Hg(-1) min 100 g ml. In the anhepatic phase, mean arterial pressure decreased from 92 mm Hg (84-98) to 85 (80-92) mm Hg and at reperfusion it was 80 (71-105) mm Hg. From the anhepatic to the reperfusion phase, the CBF increased 7% (0 to 26) for each mm Hg concomitant increase in PaCO2. The CBF to Vmean ratio remained stable (1.0 [0.8-1.2] vs. 0.9 [0.7-1.1] ml 100 g(-1) min(-1) cm(-1) sec).
  
  
  CONCLUSIONS
  During the reperfusion phase of liver transplantations, cerebrovascular dilatation uncouples cerebral oxidative metabolism from blood flow. The increase in CBF is beyond what can be explained by changes in arterial carbon dioxide tension and arterial pressure.
authors.affiliation: Department of Hepatology, Rigshospitalet, University of Copenhagen, Denmark. stolze@post3.tele.dk
authors.forename: F S
authors.initials: FS
authors.lastname: Larsen
authors.forename: E
authors.initials: E
authors.lastname: Ejlersen
authors.forename: G
authors.initials: G
authors.lastname: Strauss
authors.forename: A
authors.initials: A
authors.lastname: Rasmussen
authors.forename: P
authors.initials: P
authors.lastname: Kirkegaard
authors.forename: B A
authors.initials: BA
authors.lastname: Hansen
authors.forename: N
authors.initials: N
authors.lastname: Secher
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D005260:Female; D006706:Homeostasis; D006801:Humans; D017093:Liver Failure / Q000601:surgery; D016031:Liver Transplantation / Q000379:methods / Q000401:mortality / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011183:Postoperative Complications / Q000401:mortality; D011446:Prospective Studies; D017585:Ultrasonography, Doppler, Transcranial; D014664:Vasodilation
chemical_list: D010100:Oxygen