title: Pancreatitis complicated by gland necrosis: evolution of findings on contrast-enhanced CT.
abstract: OBJECTIVE
  The purpose of this work was to investigate the natural history of pancreatic necrosis on contrast-enhanced CT in patients managed nonoperatively.
  
  
  METHODS
  A computer-based radiology information search revealed 32 patients with pancreatic necrosis who had had serial contrast-enhanced CT scans and were managed nonoperatively. There were 23 men and 9 women with a mean age of 51 years. One hundred forty-five contrast-enhanced CT scans were retrospectively reviewed for the location and extent of necrosis. The medical records of all patients were reviewed.
  
  
  RESULTS
  The 32 patients had a mean Ranson clinical grade of 5.8 (range 3-8). Eighteen of these 32 patients were managed nonoperatively, and 14 patients required a necrosectomy after initial nonoperative management. In the 32 patients, the location of necrosis was in the head (3), body (6), tail (2), head/body (2), head/body/tail (9), body/tail (9), and head/tail (1). Extent of necrosis was 0-25% (9), 26-50% (6), 51-75% (6), and 76-100% (11). The extent of necrosis remained stable during follow-up in 22 (69%) patients and increased during follow-up in 10 (31%). Necrosectomy was performed in six (60%) patients in whom there was an increase in necrosis and eight (36%) patients in whom necrosis was stable. No patient had restoration of normal enhancement in an area that was previously necrotic. There were five patients who were managed nonoperatively (mean follow-up 318 days) in whom the necrosis eventually resorbed, forming a focal parenchymal cleft reminiscent of a scar. Five of the 32 patients died.
  
  
  CONCLUSIONS
  Pancreatic necrosis as demonstrated by CT tends to remain stable in most patients treated nonoperatively. If the extent of necrosis increases, patients are more likely to require a necrosectomy. In some patients managed nonoperatively, the pancreatic necrosis will resorb, resulting in a fat-replaced cleft reminiscent of a scar.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Vitellas
authors.forename: E K
authors.initials: EK
authors.lastname: Paulson
authors.forename: R A
authors.initials: RA
authors.lastname: Enns
authors.forename: M T
authors.initials: MT
authors.lastname: Keogan
authors.forename: T N
authors.initials: TN
authors.lastname: Pappas
mesh_terms: D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000000981:diagnostic imaging; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D010180:Pancreatectomy; D019283:Pancreatitis, Acute Necrotizing / Q000145:classification / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D011856:Radiographic Image Enhancement; D011873:Radiology Information Systems; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media