title: Image artifacts due to a time-varying contrast medium concentration in 3D contrast-enhanced MRA.
abstract: The purpose of this work was to study image effects due to time-varying contrast medium concentration in contrast-enhanced three dimensional (3D) magnetic resonance angiography (MRA) images. Two different simulation models (1D and 3D) and two different contrast medium variation schemes were used. Phantom measurements were also performed. Experiments were performed for several different bolus timings. Similar sequence and image object parameters were used in both simulations and measurements (TE/TR 2. 1/7.8 mses, flip angle 30 degrees, T1/T2 1200-80/150-40 msec, flow velocity 100 cm/sec). A small variation in bolus timing yielded large variations in the appearance of the image effects, especially if the center of k-space was sampled in the vicinity of rapid contrast medium concentration variation. For a typical bolus injection in a patient, a severe signal loss but only minor ringing and edge artifacts appeared if the bolus injection was poorly timed. Effects of pulsatile flow were minor. The 3D model proved to be a useful tool in these studies. J. Magn. Reson. Imaging 1999;10:919-928.
authors.affiliation: Department of Radiation Physics, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden. jonas.svensson@rfa.mas.lu.se
authors.forename: J
authors.initials: J
authors.lastname: Svensson
authors.forename: J S
authors.initials: JS
authors.lastname: Petersson
authors.forename: F
authors.initials: F
authors.lastname: Ståhlberg
authors.forename: E M
authors.initials: EM
authors.lastname: Larsson
authors.forename: P
authors.initials: P
authors.lastname: Leander
authors.forename: L E
authors.initials: LE
authors.lastname: Olsson
mesh_terms: D001011:Aorta / Q000033:anatomy & histology / Q000502:physiology; D016477:Artifacts; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage*; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D011673:Pulsatile Flow; D012212:Rheology; D013997:Time Factors
chemical_list: D003287:Contrast Media; D005682:Gadolinium; C038958:gadolinium chloride