title: Hepatic steatosis: a frequent non-specific finding in HIV-infected children.
abstract: Thirty HIV-infected children were cross-sectionally examined for morphologic hepatic abnormalities, using ultrasonography or histology. Abdominal ultrasonography was performed in 27 children. The liver structure was normal in four patients, one of whom had moderate symptoms of the HIV infection and three of them severe symptoms. Abnormal liver structure, compatible with hepatic steatosis, was found in 23 (85%) patients. Five of them were in an early stage of the HIV infection (category N or A), three patients were ranked in category B and 15 patients in category C. Histological examination of the liver was performed in 11 children and steatosis was documented in ten (91%). In seven (70%) of these ten children steatosis had been suspected by ultrasonography. In conclusion, steatosis is common in HIV-infected children. It is non-specific and has no impact on disease, diagnostic evaluation or management. Conclusion Ultrasonography is a sensitive, accurate, non-invasive screening tool. It is more reliable than liver function tests.
authors.affiliation: University Children's Hospital of Zürich, Infectious Diseases Unit, Steinwiesstrasse 75, CH-8032 Zürich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Albisetti
authors.forename: C P
authors.initials: CP
authors.lastname: Braegger
authors.forename: T
authors.initials: T
authors.lastname: Stallmach
authors.forename: U V
authors.initials: UV
authors.lastname: Willi
authors.forename: D
authors.initials: D
authors.lastname: Nadal
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D008111:Liver Function Tests; D012189:Retrospective Studies; D014463:Ultrasonography