title: O-mannosyl glycans in mammals.
abstract: Most proteins within living organisms contain glycans. Glycan structures can modulate the biological properties and functions of glycoproteins. The major glycans of glycoproteins can be classified into two groups, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Developments in glycobiology have revealed a new type of glycosidic linkage to the peptide portion, the O-mannosyl linkage, in mammals, while so far it had been thought to be specific to yeast. This review will give an outline of the O-mannosyl glycans of mammalian glycoproteins. Since one of the most well known O-mannosyl-modified mammalian glycoproteins is dystroglycan, the functional aspects of the O-mannosyl glycan of dystroglycan will be described to help understand this new glycobiological field.
authors.affiliation: Department of Glycobiology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, Japan. endo@tmig.or.jp
authors.forename: T
authors.initials: T
authors.lastname: Endo
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism; D049030:Dystroglycans; D005964:Glucosyltransferases; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008358:Mannose / Q000737:chemistry* / Q000378:metabolism; D008364:Mannosyltransferases / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011134:Polysaccharides / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism; D012260:Ribonucleases / Q000737:chemistry; D015003:Yeasts
chemical_list: D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D011134:Polysaccharides; C051887:glycogenin; D049030:Dystroglycans; D005964:Glucosyltransferases; D008364:Mannosyltransferases; D012260:Ribonucleases; D008358:Mannose