In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array.
A 256-element, continuous-wave ultrasonic phased array has been used to thermally coagulate deep-seated liver and kidney tissue. The array elements were formed on a 1-3 piezocomposite bowl with a 10-cm radius of curvature and 12-cm diameter. The 0.65 x 0.65 cm2 projection elements were driven at 1.1 MHz by a custom-built amplifier system. A series of in vivo porcine experiments demonstrated the ability to coagulate liver and kidney tissue using the large-scale phased array. The temperature response of the treatment was guided and monitored using magnetic resonance (MR) images. Focal lesion volumes greater than 0.5 cm3 in kidney and 2 cm3 in liver were formed from a single 20-s sonication.
Daum
D R
DR
Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Smith
N B
NB
King
R
R
Hynynen
K
K
D000818:Animals; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D013552:Swine; D014464:Ultrasonic Therapy / Q000295:instrumentation*