Ligand-binding domain of estrogen receptors.
Estrogen receptors are multi-domain proteins that interact with other proteins and DNA to fulfil their function: the regulation of transcription. During the past 2-3 years, our understanding of this complex process has increased tremendously as crystal structures of isolated ligand-binding domains in complex with various ligands, as well as co-activator peptides, are now available. The structural information, combined with new data on novel co-activators/co-repressors, muteins and their actions, and novel ligands, allows for the first time the development of detailed theories for the first steps of transcription initiation.
Mueller-Fahrnow
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A
Research Laboratories of Schering AG, Berlin, D-13342, Germany. anke. muellerfahrnow@schering.de.
Egner
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U
D000595:Amino Acid Sequence; D000818:Animals; D019281:Dimerization; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011485:Protein Binding; D011487:Protein Conformation; D011960:Receptors, Estrogen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D008024:Ligands; D011960:Receptors, Estrogen