title: Response of one-humped camel (Camelus dromedarius) to intravenous glucagon injection and to infusion of glucose and volatile fatty acids, and the kinetics of glucagon disappearance from the blood.
abstract: The effects of glucagon injection and infusion of glucose and volatile fatty acids were studied in one-humped camels. Twenty adult male camels were divided into four equal groups. The first group was infused with physiological saline and served as a control. The second group was injected with a single dose of glucagon, the third group was infused with glucose (50%) in sterile saline, and the fourth group was infused with a volatile fatty acid (VFA) mixture. In the first, third and fourth groups, sampling was performed before the beginning of infusions (control time), and at 15, 30, 60 and 120 min post-infusion. Plasma glucagon concentrations were monitored in the second group at 5, 10, 15, 20, 30, 45, 90, 105 and 120 min after injection. For glucagon injection, glucose concentration peaked at 15 min post-injection, and tended to decrease thereafter. Plasma glucose concentrations showed significant rises above the basal value at all times after glucose infusion. VFA infusion had no apparent effect on plasma glucose concentration. After injection of glucagon, the plasma lactate concentration dropped significantly at 15 and 30 min, then increased gradually until it reached the original concentration of lactate at 120 min. However, glucose infusion elevated the plasma lactate concentration only at the end of the infusion period. A decrease in plasma lactate was observed at 60 min after VFA infusion. The present investigation provides evidence that the glucagon level in camels is higher than that in other ruminants and in man, and suggests that this is a probable species specificity, which would explain the higher level of glucose in the blood of camels than in that of other ruminants. The disappearance curve of injected glucagon had, as in other ruminants, an exponential two-compartment function. The hormone was rapidly distributed and was eliminated with a high rate of clearance.
authors.affiliation: Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Fattah
authors.forename: H
authors.initials: H
authors.lastname: Amer
authors.forename: M A
authors.initials: MA
authors.lastname: Ghoneim
authors.forename: M
authors.initials: M
authors.lastname: Warda
authors.forename: Y
authors.initials: Y
authors.lastname: Megahed
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002162:Camelus / Q000097:blood*; D005232:Fatty Acids, Volatile / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D007700:Kinetics; D007773:Lactates / Q000097:blood; D008297:Male; D008954:Models, Biological; D012418:Ruminants
chemical_list: D001786:Blood Glucose; D005232:Fatty Acids, Volatile; D007773:Lactates; D005934:Glucagon; D005947:Glucose