Tc-99m erythromycin lactobionate inhalation scintigraphy in parenchymal lung diseases.
We have investigated Technetium 99m erythromycin lactobionate (Tc 99m EL) clearance from the lungs after inhalation, in the presence of an alveolitis. Eighteen patients (6 sarcoidosis, 7 idiopathic fibrosis, and 5 miliary tuberculosis) were imaged after the patients inhaled 1,110 MBq of Tc 99m EL. Clearance half time for the first 45 min, for 24 h, and retention at 24 h correlated with percentage of lymphocytes in bronchoalveolar lavage fluid (BAL) (r = .729, r = .883, and r = .826, respectively). There was a positive correlation between peripheral penetration (PP) and forced expiratory volume in 1 s (FEV1) (r = .806) and forced vital capacity (FVC) (r = .781). Retention was more marked in sarcoidosis compared with tuberculosis (0.025 < p < or = 0.05). Radioaerosol lung imaging may reflect the pulmonary function impairment in parenchymal lung diseases. Retention of Tc 99m EL may be related to number of BAL cells or presence of a lymphocytic alveolitis. Long residency time of Tc 99m EL in the lungs implies that erythromycin can also be administered by inhalation for therapeutic purposes.
Durak
H
H
Department of Nuclear Medicine, Dokuz Eylül University School of Medicine, Izmir, Turkey. hdurak@kordon.deu.edu.tr
Aktoğu
S
S
Değirmenci
B
B
Sayit
E
E
Ertay
T
T
Dereli
S
S
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006207:Half-Life; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000503:physiopathology
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C102272:technetium Tc 99m erthyromycin lactobionate; D004917:Erythromycin