Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24.
Multipoint linkage analysis was used to screen for evidence of linkage between alcoholism and five alcoholism-related quantitative traits. The results suggest that a susceptibility locus that influences monoamine oxidase activity and P300 amplitude at the Pz lead, and increases the risk of alcohol dependence may be linked to markers in the 12q24 region. Furthermore, the susceptibility for alcoholism may be associated with allele 3 (allele size 144) of D12S392.
Juo
S H
SH
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Pugh
E W
EW
Baffoe-Bonnie
A
A
Kingman
A
A
Sorant
A J
AJ
Klein
A P
AP
O'Neill
J
J
Mathias
R A
RA
Wilson
A F
AF
Bailey-Wilson
J E
JE
D000437:Alcoholism / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008126:Lod Score; D008995:Monoamine Oxidase / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D018709:Statistics, Nonparametric
D005819:Genetic Markers; D008995:Monoamine Oxidase