Use of corticosteroids for nasal allergy in children.
A literature review is presented regarding studies of systemic and side effects of corticosteroids for topical treatment in the airways. Systemic effects studied are plasma and urine cortisol, with and without cosyntropin stimulation test. Generally, doses lower than 400 microg had no discernible effects. All studies found were performed on adults. Side effects are, e.g. cataract, septal perforation, and bone growth retardation. The latter side effect is studied in children with asthma, e.g. with knemometry. Generally, doses of 400 microg a day or less of 'modern' corticosteroids did not reduce the growth rate. No report is found concerning septal perforation in children.
Malm
L
L
Department of Otorhinolaryngology, University Hospital, Malmö, Sweden. lars.malm@oron.mas.lu.se
Wihl
J A
JA
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy; D001846:Bone Development / Q000187:drug effects; D002648:Child; D005938:Glucocorticoids / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013256:Steroids
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D013256:Steroids