title: Ewing's sarcoma: prognosis and survival in Mexican children from a single institution.
abstract: A retrospective analysis of 55 patients with Ewing's sarcoma from an institution in Mexico was done between 1980 and 1993. The ages ranged between 2 and 16 years (mean 9.78); 39 were male and 16 female. The most frequent primary sites were in the humerus in 13 of 55 patients (23.6%), followed by the pelvis in 10 out of 55 (18%). Sixty percent of the patients had metastasic disease at diagnosis; the lungs and bones were the most frequently affected sites. Patients with localized disease (n = 22) had a disease-free survival (DFS) of 44%, compared with 20% of those with pulmonary metastasic disease (n = 7) and 8% of patients with metastasic disease to the lungs and elsewhere (n = 26) (p = .00061). Patients in regimen 3 had a DFS of 47% at 36 months of follow-up compared to 20 and 25% for patients in regimens 1 and 2, respectively (p = .01). In those with trunk presentation the DFS was of 25% and in those with presentation in the extremities DFS was 50% (p = .01). Patients with pulmonary metastasic disease at diagnosis have a DFS of 20% in comparison to those without (44%) (p = .00061).
authors.affiliation: Department of Pediatric Oncology, Instituto Nacional de Pediatría, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Cárdenas-Cardós
authors.forename: R
authors.initials: R
authors.lastname: Rivera-Luna
authors.forename: N A
authors.initials: NA
authors.lastname: López-Facundo
authors.forename: C
authors.initials: C
authors.lastname: Leal-Leal
authors.forename: R
authors.initials: R
authors.lastname: Gómez-Martínez
authors.forename: A
authors.initials: A
authors.lastname: Castellanos-Toledo
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012512:Sarcoma, Ewing / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D015996:Survival Rate