title: Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
abstract: A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: S
authors.initials: S
authors.lastname: Jew
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: M G
authors.initials: MG
authors.lastname: Kim
authors.forename: E Y
authors.initials: EY
authors.lastname: Roh
authors.forename: C I
authors.initials: CI
authors.lastname: Hong
authors.forename: J K
authors.initials: JK
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Park
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002166:Camptothecin