[High creatine kinase MB concentration and activity in patients with rhabdomyosarcoma].
A 14-year-old boy with rhabdomyosarcoma (RMS) of the left palm showed increased concentration and activity of creatine kinase (CK; EC 2.7.3.2) MB in his serum. CK isoenzyme analysis revealed no extra band. Other laboratory data including high lactate dehydrogenase (LD) isoenzyme 2, CK isoenzyme BB and MB, neuron specific enolase (NSE), and clinical findings did not support the diagnosis of myocardial infarction. The high activity and concentration of CK-MB in serum is possibly originated from the tumor. We could follow his time-course and analyze laboratory data of him and other 6 patients with RMS. We concluded that CK-MB, both concentration and activity, was the more sensitive marker of disease states of RMS than NSE and LD to follow up the patients with RMS.
Sawabe
S
S
Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo.
Hara
K
K
Maekawa
M
M
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006225:Hand; D006801:Humans; D007527:Isoenzymes; D008297:Male; D012208:Rhabdomyosarcoma / Q000201:enzymology*; D012983:Soft Tissue Neoplasms / Q000201:enzymology*
D015415:Biomarkers; D007527:Isoenzymes; D003402:Creatine Kinase