Functional MRI in children with epilepsy.
Advances in brain mapping with functional magnetic resonance imaging (fMRI) have opened an important window into understanding how language is organized in the developing brain. Children with epilepsy, particularly those anticipating surgical intervention, may benefit from preoperative language localization with fMRI, thus minimizing the risk of incurring new deficits. Clinical applications of fMRI, however, await more information on how different linguistic skills are represented in the developing brain and how epileptic lesions impact on this organization at different stages of cognitive development. This article presents some of the current methods for brain mapping in children as well as early results using fMRI for language mapping in pediatric epilepsy.
Bookheimer
S Y
SY
Division of Brain Mapping, University of California, Los Angeles, CA, USA. sbook@ucla.edu
Dapretto
M
M
Karmarkar
U
U
D002657:Child Development; D002675:Child, Preschool; D004292:Dominance, Cerebral; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D007804:Language Development; D008279:Magnetic Resonance Imaging / Q000379:methods; D012016:Reference Values