High-level aminoglycoside resistance in the beta-hemolytic group G Streptococcus isolate BM2721.
The beta-hemolytic group G Streptococcus clinical isolate BM2721 was resistant to high levels of aminoglycosides by synthesis of AAC(6')-APH(2"), APH(3')-III, and ANT(6) modifying enzymes. The corresponding genes were found to be adjacent as the result of a recombination event between Tn4001 and Tn5405, two transposons originating in staphylococci.
Galimand
M
M
Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France. galimand@pasteur.fr
Lambert
T
T
Gerbaud
G
G
Courvalin
P
P
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D015247:Deoxyribonuclease HindIII / Q000737:chemistry; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000235:genetics; D016678:Genome; D006801:Humans; D008826:Microbial Sensitivity Tests; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013290:Streptococcal Infections / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects* / Q000235:genetics
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D015247:Deoxyribonuclease HindIII