title: Antimicrobial resistance of diarrheagenic Escherichia coli isolated from children under the age of 5 years from Ifakara, Tanzania.
abstract: Diarrhea caused by multidrug-resistant bacteria is an important public health problem among children in developing countries. The prevalence and antimicrobial susceptibility of diarrheagenic Escherichia coli in 346 children under 5 years of age in Ifakara, Tanzania, were studied. Thirty-eight percent of the cases of diarrhea were due to multiresistant enterotoxigenic E. coli, enteroaggregative E. coli, or enteropathogenic E. coli. Strains of all three E. coli categories showed high-level resistance to ampicillin, tetracycline, co-trimoxazole, and chloramphenicol but were highly susceptible to quinolones. Guidelines for appropriate use of antibiotics in developing countries need updating.
authors.affiliation: Departament de Microbiologia, Hospital Clinic, IDIBAPS (Institut d'Investigacions Biomèdiques August Pí i Sunyer), Barcelona 08036, Spain. vila@medicina.ub.es
authors.forename: J
authors.initials: J
authors.lastname: Vila
authors.forename: M
authors.initials: M
authors.lastname: Vargas
authors.forename: C
authors.initials: C
authors.lastname: Casals
authors.forename: H
authors.initials: H
authors.lastname: Urassa
authors.forename: H
authors.initials: H
authors.lastname: Mshinda
authors.forename: D
authors.initials: D
authors.lastname: Schellemberg
authors.forename: J
authors.initials: J
authors.lastname: Gascon
mesh_terms: D002675:Child, Preschool; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003967:Diarrhea / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005798:Genes, Bacterial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D013636:Tanzania
chemical_list: D004269:DNA, Bacterial