title: Meta-analysis by combining p-values: simulated linkage studies.
abstract: Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were consistently found by pooling raw data. In the absence of further information, combining p-values can provide an overall, but limited, assessment of different linkage studies. However, meta-analysis would be better viewed as a preliminary step toward the goal of analyzing the pooled raw data.
authors.affiliation: Department of Statistical Science, Southern Methodist University, Dallas, TX 75275, USA.
authors.forename: R
authors.initials: R
authors.lastname: Guerra
authors.forename: C J
authors.initials: CJ
authors.lastname: Etzel
authors.forename: D R
authors.initials: DR
authors.lastname: Goldstein
authors.forename: S R
authors.initials: SR
authors.lastname: Sain
mesh_terms: D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D015999:Multivariate Analysis
chemical_list: D005819:Genetic Markers