Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease.
There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
Shimura-Miura
H
H
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Hattori
N
N
Kang
D
D
Miyako
K
K
Nakabeppu
Y
Y
Mizuno
Y
Y
D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers; D045643:DNA Repair Enzymes; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008928:Mitochondria / Q000201:enzymology* / Q000473:pathology; D008956:Models, Chemical; D019578:Multiple System Atrophy / Q000201:enzymology; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D012016:Reference Values; D013378:Substantia Nigra / Q000201:enzymology* / Q000473:pathology
D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D010744:Phosphoric Monoester Hydrolases; C078207:8-oxodGTPase; D045643:DNA Repair Enzymes; D003849:Deoxyguanosine