Inhibitory effect of propolis and bee venom on the mutagenicity of some direct- and indirect-acting mutagens.
The antimutagenic effect of ethanolic extract of propolis (EEP) and honeybee (Apis mellifera) venom, both collected in the State of São Paulo, Brazil, was assessed by the Salmonella/microsome assay upon direct- and indirect-acting mutagens. EEP had inhibitory effect (in an ascending order) on the mutagenicity power of daunomycin (TA102), benzo(a)pyrene (TA100), and aflatoxin B(1)(TA98) and the venom acted against the mutagenicity of 4-nitro-o-phenylenediamine (TA98) and daunomycin (TA102). Teratogenesis Carcinog. Mutagen. 19:403-413, 1999.
Varanda
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EA
Department of Biological Sciences-Faculty of Pharmaceutical Sciences of Araraquara, Estadual Paulist University, São Paulo, Brazil. varandae@boldo.fcfar.unesp.br
Monti
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Tavares
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DC
D016604:Aflatoxin B1 / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000494:pharmacology; D001938:Brazil; D003630:Daunorubicin / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D010655:Phenylenediamines / Q000494:pharmacology; D011429:Propolis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*
D016587:Antimutagenic Agents; D001514:Bee Venoms; D009153:Mutagens; D010655:Phenylenediamines; D001564:Benzo(a)pyrene; C012277:1,2-diamino-4-nitrobenzene; D011429:Propolis; D016604:Aflatoxin B1; D003630:Daunorubicin