title: New biphenyl compounds with DNA strand-scission activity from Clusia paralicola.
abstract: Three new biphenyl derivatives, clusiparalicolines A (1), B (2), and C (3), were isolated from the roots of Clusia paralicola by bioassay-directed fractionation using the DNA strand-scission and the KB human cancer cell line cytotoxicity assays. Compounds 1 and 2 were found to be active in the DNA strand-scission assay, whereas all three compounds exhibited modest cytotoxicity against the KB cell line. The structures of 1-3 were elucidated by spectroscopic methods including 1D and 2D NMR techniques.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709, USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Seo
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: H
authors.initials: H
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification* / Q000494:pharmacology; D002396:Catechols / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002489:Central America; D004273:DNA, Neoplasm / Q000187:drug effects*; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013020:South America; D013055:Spectrophotometry, Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D002396:Catechols; D004273:DNA, Neoplasm; D010636:Phenols; C402902:clusiparalicoline A; C402903:clusiparalicoline B; C402904:clusiparalicoline C