Pial involvement in Wegener's granulomatosis shown on MRI.
Involvement of the brain and meninges is rare in Wegener's granulomatosis (WG); it has been reported in 1.2-8 % of patients. Meningeal involvement in WG has been reported in imaging as being confined to the dura mater, and is thought to represent granulomatous infiltration. We present a case of WG with abnormal pial enhancement and involvement of the perivascular spaces on MRI, pathologically proven to represent granulomatous infiltration due to the primary disease rather than to infection.
Nusbaum
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AO
Department of Radiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Morgello
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S
Atlas
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SW
D000328:Adult; D001099:Arachnoid / Q000473:pathology; D001706:Biopsy; D004388:Dura Mater / Q000473:pathology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000473:pathology; D018396:Mucin-1 / Q000032:analysis; D010841:Pia Mater / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D018396:Mucin-1; D014746:Vimentin