Changes in immunomodulatory activity of human mononuclear cells after cultivation with leaf decoctions from the genus Ligustrum L.
Leaf decoctions from Ligustrum vulgare (LV) and Ligustrum delavayanum (LD) were studied for candidacidal activity, phagocytic activity studied on human mononuclear cells (MO) and complement activated by the classical pathway. Candidacidal activity was studied on Candida albicans SC 1539 incubated with MO. The decoction of LD increased the candidacidal activity of MO, whereas LV did not show any effect. The phagocytic activity of MO was decreased by the decoction of LV, whereas LD did not change the activity. The phagocytic index of MO incubated with LD decoction was increased, but use of the LV decoction did not show significant changes. Decoctions from LD and LV significantly decreased the haemolytic activity of complement activated by the classical pathway (conc. 0.78 mg/mL).
Baróniková
S
S
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovakia.
Nagy
M
M
Grancai
D
D
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D003167:Complement Activation / Q000187:drug effects* / Q000502:physiology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008516:Medicine, Chinese Traditional; D010587:Phagocytosis / Q000187:drug effects* / Q000502:physiology; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal