Effect of stobadine on oxygen free radical generation in stimulated human polymorphonuclear leukocytes.
The generation both superoxide and a mixture of reactive oxygen species was recorded in a suspension of human polymorphonuclear leukocytes stimulated with phorbol myristate acetate. While stobadine dose-dependently decreased chemiluminescence, only its highest concentration used reduced significantly superoxide generation. The results suggest that stobadine is a more effective scavenger of free radicals rather than a quencher of superoxide anion.
Pecivová
J
J
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. exfajape@savba.sk
Drábiková
K
K
Kotuliaková
K
K
Macicková
T
T
Nosál
R
R
Danihelová
E
E
D000975:Antioxidants / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D005609:Free Radicals / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D016897:Respiratory Burst / Q000187:drug effects; D013268:Stimulation, Chemical; D013481:Superoxides / Q000097:blood*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000494:pharmacology
D000975:Antioxidants; D002243:Carbolines; D016166:Free Radical Scavengers; D005609:Free Radicals; D013481:Superoxides; D013755:Tetradecanoylphorbol Acetate; C100106:dicarbine