title: Docetaxel neuropathy: a distal axonopathy.
abstract: Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m(2). Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.
authors.affiliation: Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Fazio
authors.forename: A
authors.initials: A
authors.lastname: Quattrini
authors.forename: A
authors.initials: A
authors.lastname: Bolognesi
authors.forename: G
authors.initials: G
authors.lastname: Bordogna
authors.forename: E
authors.initials: E
authors.lastname: Villa
authors.forename: S
authors.initials: S
authors.lastname: Previtali
authors.forename: N
authors.initials: N
authors.lastname: Canal
authors.forename: R
authors.initials: R
authors.lastname: Nemni
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001369:Axons / Q000473:pathology*; D000077143:Docetaxel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D017239:Paclitaxel / Q000009:adverse effects / Q000031:analogs & derivatives*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel