Protection of acutely ischemic myocardium by controlled reperfusion.
The goal of revascularization after acute occlusion of a coronary artery is the return of contractile function and the reduction of mortality. Although reperfusion of ischemic myocardium is a prerequisite for return of function, it may, in itself, cause further injury. Controlled blood cardioplegic reperfusion reduces this "reperfusion injury" and provides maximal myocardial protection. In this article, we review recent advances in surgically controlled reperfusion and speculate on future prospects for myocardial protective techniques in patients with acute coronary artery occlusion.
Schlensak
C
C
Division of Cardiovascular Surgery, Universtiy of Freiburg, Germany. schlensa@ch11.ukl.uni-freiburg.de
Doenst
T
T
Kobba
J
J
Beyersdorf
F
F
D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D002986:Clinical Trials as Topic; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D015337:Multicenter Studies as Topic; D015425:Myocardial Reperfusion / Q000295:instrumentation*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D009204:Myocardial Revascularization