title: Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397).
authors.affiliation: Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: S
authors.initials: S
authors.lastname: Ozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Miyaji
authors.forename: S
authors.initials: S
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasawa
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D001562:Benzimidazoles; C402921:J 113397; D010880:Piperidines; D011957:Receptors, Opioid