title: [Increased neuron-specific enolase levels in patients with long-standing pyothorax-associated lymphoma].
abstract: A 78-year-old man was admitted for the evaluation of chest pain and a subcutaneous giant mass in the left chest, which had been growing for 3 months. A computed tomogram of the chest revealed a giant tumor attached to the parietal pleura with calcification of long-standing pyothorax. Pathological findings of a specimen obtained from this tumor showed diffuse proliferation of large atypical lymphocytes with 1-2 nucleoli and abundant cytoplasm. In immunohistochemical studies, tumor cells stained positive for CD20 but not for CD45 RO. The diagnosis was long-standing pyothorax-associated lymphoma (diffuse large-cell lymphoma, B-cell type). The patient's serum neuron-specific enolase (NSE) level was 101 ng/ml on admission, and declined in tandem with a chemotherapy-induced decrease in tumor size. In addition, immunohistochemical studies showed staining of tumor cells by anti-NSE polyclonal antibody. Although rarely observed in patients with malignant lymphoma, increased serum NSE levels may serve as an index of chemotherapeutic effectiveness.
authors.affiliation: Respiratory Department, Taragi Municipal Hospital, Kumamoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kashiwabara
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: H
authors.initials: H
authors.lastname: Yagyu
authors.forename: H
authors.initials: H
authors.lastname: Kusama
authors.forename: T
authors.initials: T
authors.lastname: Matsuoka
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D016724:Empyema, Pleural / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood*
chemical_list: D015415:Biomarkers; D010751:Phosphopyruvate Hydratase