Natural killer cells: stress out, turn on, tune in.
Natural killer cells attack tumor cells, infected cells and some normal cells, but the basis of their specificity is not completely understood. Recent studies indicate that epithelial tumor cells upregulate a stress-induced MHC class-I-like protein termed MICA, triggering NK cells via a recently described receptor called NKG2D.
Diefenbach
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Department of Molecular and Cell Biology, Cancer Research Laboratory, 485 Life Sciences Addition, University of California at Berkeley, Berkeley, 94720-3200, USA.
Raulet
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D000818:Animals; D002277:Carcinoma / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009363:Neoplasm Proteins / Q000276:immunology*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000276:immunology*; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology
C120528:HCST protein, human; C492355:Hcst protein, mouse; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; C527085:KLRK1 protein, human; C527086:Klrk1 protein, mouse; C099187:MHC class I-related chain A; C098080:MICB antigen; D008565:Membrane Proteins; D055655:NK Cell Lectin-Like Receptor Subfamily K; D009363:Neoplasm Proteins; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell