Effectiveness of pneumococcal polysaccharide vaccine for preschool-age children with chronic disease.
To estimate the effectiveness of pneumococcal polysaccharide vaccine, we serotyped isolates submitted to the Pneumococcal Sentinel Surveillance System from 1984 to 1996 from 48 vaccinated and 125 unvaccinated children 2 to 5 years of age. Effectiveness against invasive disease caused by serotypes included in the vaccine was 63%. Effectiveness against serotypes in the polysaccharide vaccine but not in a proposed seven-valent protein conjugate vaccine was 94%.
Fiore
A E
AE
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. abf4@cdc.gov
Levine
O S
OS
Elliott
J A
JA
Facklam
R R
RR
Butler
J C
JC
D001428:Bacterial Vaccines; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D018571:Sentinel Surveillance; D012703:Serotyping; D012805:Sickle Cell Trait; D013296:Streptococcus pneumoniae / Q000145:classification*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines