A method for meta-analysis of genome searches: application to simulated data.
Genome searches have been performed for many complex traits, and in some cases several searches have been performed in a single disease. Replication of significant results is rare, and a systematic method of reviewing results from a number of searches is needed. A method for meta-analysis is presented which provides a systematic descriptive overview of the separate analyses while dealing with some of the problems specific to meta-analysis of genome searches. The results of two separate meta-analyses correctly indicate the presence of susceptibility loci on chromosomes 1, 3, and 5 in the GAW11 Problem 2 data.
Wise
L H
LH
Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, King's College London, UK.
Lewis
C M
CM
D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods*; D016678:Genome; D005838:Genotype; D006801:Humans; D015201:Meta-Analysis as Topic; D008957:Models, Genetic; D015233:Models, Statistical; D020412:Multifactorial Inheritance; D012984:Software
D005819:Genetic Markers