title: Population choice in mapping genes for complex diseases.
abstract: The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions.
authors.affiliation: MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK. alan.wright@hgu.mrc.ac.uk
authors.forename: A F
authors.initials: AF
authors.lastname: Wright
authors.forename: A D
authors.initials: AD
authors.lastname: Carothers
authors.forename: M
authors.initials: M
authors.lastname: Pirastu
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype