Cognitive development in benign focal epilepsies of childhood.
Benign focal epilepsy of childhood (BFEC) is the most common form of epilepsy, in children from 3 to 12 years. Its prognosis is always favourable as far as the epilepsy is concerned. Nevertheless, recent clinical data suggest that children affected by BFEC are more likely to show learning difficulties and behavioural disturbances than their peers. We report here the preliminary findings of a prospective study of 22 children affected with BFEC. Electroclinical and neuropsychological changes observed during the first 18 months of the follow-up strengthen the conclusion of recent neuropsychological studies stressing the correlation between epilepsy and cognitive performances. The cognitive deficits affecting mainly non-verbal functions were significantly correlated with the frequency of seizures and spike-wave discharges and to the lateralization of the epileptic focus in the right hemisphere, whereas frontal functions like attention control, response organization and fine motor speed, were impaired in the presence of active BFEC independently of the lateralization of the epileptic focus. Our results indicate that maturing cognitive functions subserved by a cortical area distant from the epileptic focus are susceptible to interference with epilepsy.
Metz-Lutz
M N
MN
INSERM U 398, Clinique Neurologique, Hôpitaux Universitaires de Strasbourg, France. metzlutz@neurochem.u-strasbg.fr
Kleitz
C
C
de Saint Martin
A
A
Massa
R
R
Hirsch
E
E
Marescaux
C
C
D001921:Brain / Q000503:physiopathology; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D004007:Dichotic Listening Tests; D004423:Ear / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology* / Q000523:psychology*; D007839:Functional Laterality; D006801:Humans; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D014706:Verbal Learning