title: A 12-year follow-up of a methadone medical maintenance program.
abstract: Methadone Medical Maintenance (MDM) is an alternative for treatment of stable methadone maintained individuals. It involves a monthly physician's visit, at which methadone take-home doses are dispensed to last until the next appointment. The safety and efficacy of this treatment modality is currently under investigation. The purpose of this study was to evaluate the long-term safety and efficacy of MDM in a methadone program in Baltimore. A sample of 21 patients was enrolled in the study and followed for 12 years. They were evaluated once a month by a primary care physician affiliated with a methadone clinic who collected urine toxicology samples and dispensed the monthly methadone dose. The results showed that only 6 (28.6%) patients dropped out during the 12 years of the study. Twelve (0.5%) of 2,290 urine samples collected were positive for drugs. No methadone overdose or diversion was observed. Participants reported significant improvement in their quality of life. The results of this study support the safety and efficacy of medical maintenance of stable methadone maintained individuals.
authors.affiliation: Division of Drug and Alcohol Abuse, University of Maryland School of Medicine, Baltimore, USA. rschwart@umpsy4.umaryland.edu
authors.forename: R P
authors.initials: RP
authors.lastname: Schwartz
authors.forename: R K
authors.initials: RK
authors.lastname: Brooner
authors.forename: I D
authors.initials: ID
authors.lastname: Montoya
authors.forename: M
authors.initials: M
authors.lastname: Currens
authors.forename: M
authors.initials: M
authors.lastname: Hayes
mesh_terms: D000328:Adult; D015142:Baltimore; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D017387:Investigational New Drug Application; D008297:Male; D008691:Methadone / Q000008:administration & dosage*; D008875:Middle Aged; D010348:Patient Care Team; D012646:Self Administration; D016896:Treatment Outcome
chemical_list: D008691:Methadone