title: Malar metastasis from rectal carcinoma: a case report.
abstract: Facial metastasis from colorectal carcinoma is extremely rare. Only two cases have been reported in the literature. This is the first reported case of malar metastasis from colon carcinoma. The patient was a 64-year-old, white woman who underwent a low anterior resection for a nearly obstructive carcinoma at 20 cm. Her chest X-ray revealed lung metastases. Postoperatively she was treated with fluorouracil and leucovorin. Twenty months later, she presented with left facial edema, which progressively increased in size. CT scan and magnetic resonance imaging with gadolinium showed a large soft tissue mass centered about the left anterior zygomatic arch. The platysma muscle was displaced laterally, and the masseter muscle was involved. There was extension into the masticator space and bony involvement of the zygomatic arch. True-cut biopsy of the left cheek revealed metastatic adenocarcinoma. Histology was similar to that of the primary rectal adenocarcinoma. Metastasis to the malar region is extremely rare. It is a grave prognostic sign, as it is associated with advanced terminal disease. Because of the widespread metastases, only palliative treatment can be provided.
authors.affiliation: Department of General Surgery, Monmouth Medical Center, Long Branch, New Jersey, USA.
authors.forename: D
authors.initials: D
authors.lastname: Danikas
authors.forename: S J
authors.initials: SJ
authors.lastname: Theodorou
authors.forename: M L
authors.initials: ML
authors.lastname: Arvanitis
authors.forename: L M
authors.initials: LM
authors.lastname: Zinterhofer
authors.forename: A A
authors.initials: AA
authors.lastname: Rienzo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D000931:Antidotes / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007415:Intestinal Obstruction / Q000601:surgery; D002955:Leucovorin / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D010166:Palliative Care; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery; D012888:Skull Neoplasms / Q000473:pathology / Q000556:secondary*; D015050:Zygoma / Q000473:pathology*
chemical_list: D000931:Antidotes; D000964:Antimetabolites, Antineoplastic; D002955:Leucovorin; D005472:Fluorouracil