Structural organization and chromosome location of the mouse elongin A gene (Tceb3).
Elongin A is the transcriptionally active subunit of the Elongin complex, which strongly increases the rate of elongation by RNA polymerase II by suppressing the transient pausing of the polymerase at many sites within transcription units. In the present study, we obtained the cDNA sequence of the mouse Elongin A gene (Tceb3) and characterized its genomic structure. The deduced 773-amino acid sequence of mouse Elongin A shows 91% and 81% identity with rat and human Elongin A, respectively. The Elongin A gene was mapped to mouse chromosome 4D3 by fluorescence in situ hybridization.
Aso
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Department of Viral Oncology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan. taso@jfcr.or.jp
Amimoto
K
K
Takebayashi
S
S
Okumura
K
K
Hatakeyama
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018076:DNA, Complementary; D000075065:Elongin; D005091:Exons; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D012319:RNA Polymerase II / Q000378:metabolism; D051381:Rats; D011994:Recombinant Proteins / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D018076:DNA, Complementary; C000616397:ELOA protein, human; C000616403:Eloa protein, mouse; C000616404:Eloa protein, rat; D000075065:Elongin; D011994:Recombinant Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II