title: Role of annexin II tetramer in plasminogen activation.
abstract: The enzymatic cascade triggered by activation of plasminogen has been implicated in a variety of normal and pathologic events, such as fibrinolysis, wound healing, tissue remodeling, embryogenesis, and the invasion and spread of transformed tumor cells. Recent data established that the Ca(2+)- and phospholipid-binding protein, annexin II heterotetramer (AIIt) binds tissue-type plasminogen activator (tPA), plasminogen, and plasmin, and dramatically stimulates the tPA-dependent conversion of plasminogen to plasmin in vitro. Interestingly, the binding of plasmin to AIIt can inhibit the activity of the enzyme, suggesting that plasmin bound to the cell surface is regulated by AIIt. The existing experimental evidence suggests that AIIt is the key physiological receptor for plasminogen on the extracellular surface of endothelial cells.
authors.affiliation: Department of Biochemistry, University of Calgary, Alberta, Canada.
authors.forename: H M
authors.initials: HM
authors.lastname: Kang
authors.forename: K S
authors.initials: KS
authors.lastname: Choi
authors.forename: G
authors.initials: G
authors.lastname: Kassam
authors.forename: S L
authors.initials: SL
authors.lastname: Fitzpatrick
authors.forename: M
authors.initials: M
authors.lastname: Kwon
authors.forename: D M
authors.initials: DM
authors.lastname: Waisman
mesh_terms: D000818:Animals; D017306:Annexin A2 / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator; D010959:Tissue Plasminogen Activator / Q000378:metabolism
chemical_list: D017306:Annexin A2; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin