title: Resistance in Campylobacter species: increased resistance to fluoroquinolones and seasonal variation.
abstract: To identify epidemiological features of culture-proven campylobacter infections and to determine resistance rates, we conducted a 4-year demographic survey of culture-proven campylobacteriosis in one Dutch region. Examination of 24,435 fecal specimens revealed 1,315 cases of campylobacteriosis (5.4%). The ofloxacin-resistance rate among Campylobacter isolates increased from 11% to 29%. Resistance against tetracycline fluctuated between 7% and 15%, and resistance against erythromycin remained low. Resistance against fluoroquinolones was seasonally influenced, with relatively high rates during winter. We conclude that resistance of Campylobacter isolates to fluoroquinolones is still rising, probably because of the use of fluoroquinolones (enrofloxacin) in animal husbandry.
authors.affiliation: Department of Infectious Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Talsma
authors.forename: W G
authors.initials: WG
authors.lastname: Goettsch
authors.forename: H L
authors.initials: HL
authors.lastname: Nieste
authors.forename: P M
authors.initials: PM
authors.lastname: Schrijnemakers
authors.forename: M J
authors.initials: MJ
authors.lastname: Sprenger
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012621:Seasons
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones