[Monoamine oxidase, tribulin, isatin: basic and applied medical aspects].
Monoamine oxidase (MAO) catalyzes the biological degradation of the neurotransmitters monoamines. The altered substrate specificity of MAO may be of pathogenic importance in some cases and MAO inhibitors showed a therapeutical effect in the experimental setting. Analyzing the efficacy of various compounds in inhibiting MAO A and B revealed new approaches to designing new-generation MAO inhibitors. Tribulin is a fraction of endogenous MAO inhibitors that are present in human and animal tissues and biological fluids. Isatin is an endogenous indole which was initially derived from a tribulin fraction. An investigation of the biological properties of tribulin revealed its heterogeneity and some chemical components were identified. It was shown that deficiency of tribulin components that selectively inhibited MAO A long with a larger number of molecules of this enzyme might be of great importance for the development of alcoholism. In addition to MAO inhibition, the physiological concentrations of isatin inhibited the receptor-binding of atrial natriuretic peptides and ANP-stimulated guanylate cyclase (GC). The sensitivity of ANP-GC to isatin might be allosterically regulated. Selective antagonists of natriuretic peptide receptors were found among isatin analogues which may be an effective pharmacological tool for further studies of the role of natriuretic peptides in the body.
Medvedev
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AE
D000302:Adrenal Cortex / Q000187:drug effects* / Q000201:enzymology; D000437:Alcoholism / Q000201:enzymology; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D007510:Isatin / Q000494:pharmacology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D017461:Receptors, Atrial Natriuretic Factor / Q000037:antagonists & inhibitors
D008996:Monoamine Oxidase Inhibitors; D018377:Neurotransmitter Agents; D007510:Isatin; C039776:tribulin; D009320:Atrial Natriuretic Factor; D008995:Monoamine Oxidase; D017461:Receptors, Atrial Natriuretic Factor
Monoaminoksidazy, tribulin, izatin: fundamental'nye i prikladnye meditsinskie aspekty.