Designed molecules that fold to mimic protein secondary structures.
Molecules that fold to mimic protein secondary structures have emerged as important targets of bioorganic chemistry. Recently, a variety of compounds that mimic helices, turns, and sheets have been developed, with notable advances in the design of beta-peptides that mimic each of these structures. These compounds hold promise as a step toward synthetic molecules with protein-like properties and as drugs that block protein-protein interactions.
Stigers
K D
KD
Department of Chemistry, 535B Rowland Hall, University of California, Irvine, CA 92697-2025, USA. kstigers@uci.edu.
Soth
M J
MJ
Nowick
J S
JS
D002240:Carbohydrate Sequence; D015195:Drug Design; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; D011506:Proteins