Regional distribution of parkinsonism-preventing endogenous tetrahydroisoquinoline derivatives and an endogenous parkinsonism-preventing substance-synthesizing enzyme in monkey brain.
1,2,3,4-Tetrahydroisoquinoline (TIQ) and 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), which exist in the brain of several mammalian species, are parkinsonism-inducing substances, and 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), which is enzymatically synthesized in rat brain, is a parkinsonism-preventing substance. In this study, we examined the regional distribution of contents of TIQ, 1MeTIQ, and 1BnTIQ, and activity of 1MeTIQ-synthesizing enzyme in monkey brain. The TIQ and 1BnTIQ contents in cerebrum and substantia nigra, and the 1MeTIQ contents in striatum and substantia nigra were higher than those in other brain regions, and 1MeTIQ-synthetic activity was high in cerebrum and thalamus. We speculate that 1MeTIQ-synthesizing enzyme may play an important role in idiopathic Parkinson's disease.
Yamakawa
T
T
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
Kotake
Y
Y
Fujitani
M
M
Shintani
H
H
Makino
Y
Y
Ohta
S
S
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D007546:Isoquinolines / Q000378:metabolism*; D008252:Macaca fascicularis; D020734:Parkinsonian Disorders / Q000517:prevention & control*; D044005:Tetrahydroisoquinolines; D014018:Tissue Distribution
D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C050386:1-methyl-1,2,3,4-tetrahydroisoquinoline; C014843:1,2,3,4-tetrahydroisoquinoline; C084924:1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline