Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl]- 3,5-pyridine dicarboxylate.
The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum.
Tunçbilek
M
M
Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Turkey.
Ozbey
S
S
Kendi
E
E
Yildirim
E
E
Erol
K
K
Ertan
R
R
D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D014961:X-Ray Diffraction
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C403050:dimethyl-1,4-dihydro-2,6-dimethyl-4-(4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridine dicarboxylate; C038806:1,4-dihydropyridine