title: Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes.
abstract: The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives.
authors.affiliation: Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, Chatenay-Malabry, France. serge.kirkiacharian@cep.u-psud.fr
authors.forename: S
authors.initials: S
authors.lastname: Kirkiacharian
authors.forename: P G
authors.initials: PG
authors.lastname: Koutsourakis
authors.forename: D
authors.initials: D
authors.lastname: Philibert
authors.forename: F
authors.initials: F
authors.lastname: Bouchoux
authors.forename: P
authors.initials: P
authors.lastname: Van de Velde
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011987:Receptors, Steroid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007192:Indenes; D011987:Receptors, Steroid