[Correction of diabetic neuropathies using aldose reductase inhibitors and pikamilon].
Streptosotocin-induced diabetes in rats is accompanied by the development of diabetic complications such as neuropathies. [2-14C]serotonin and [U-14C]GABA release from the neurotransmitter pre-loaded synaptosomes showed significant elevation. Aldose reductase inhibitors (AL-1576, sorbinil) administration leads to partial restoration of serotonin and GABA release, while picamilon restored only GABA release. It was shown that Na+,K(+)-ATPase activities decreased in synaptosomes, synaptic membranes and sciatic nerve of diabetic rats compared to control. Administration of AL-1576 normalized Na+, K(+)-ATPase activity, while sorbinil and picamilon less effectively. Sorbitol level are increased in streptozotocin-diabetic rats as compared to control. The picamilon and aldose reductase inhibitors administration to diabetic rats is accompanied by the partial reduction of brain sorbitol level. The findings confirm the important role of picamilon and aldose reductase inhibitors in the prevention and treatment of diabetic neuropathy.
Kuchmerovskaia
T M
TM
Institute of Biochemistry, Kiev.
Parkhomets
P K
PK
Donchenko
G V
GV
Obrosova
I G
IG
Klimenko
A P
AP
Kuchmerovskiĭ
N A
NA
Pakirbaeva
L V
LV
Efimov
A S
AS
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005449:Fluorenes / Q000627:therapeutic use*; D006827:Hydantoins / Q000627:therapeutic use*; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013012:Sorbitol / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D005449:Fluorenes; D006827:Hydantoins; D018697:Nootropic Agents; C052241:imirestat; D012701:Serotonin; C044905:nicotinoyl-GABA; D013012:Sorbitol; D005680:gamma-Aminobutyric Acid; D000449:Aldehyde Reductase
Korrektsiia diabeticheskikh neĭropatiĭ s pomoshch'iu ingibitorov al'dozoreduktazy i pikamilona.