Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.
N-methylmorpholine, which is used as a catalyst in polyurethane foams producing, in solvents, stabilizing agents, and corrosion inhibitors, was administered to female rats by gavage at 100, 200, 600, and 900 mg/kg during organogenesis. It did not exhibit selective toxicity toward the developing conceptus. This compound administered to pregnant females was fetotoxic and teratogenic in the presence of maternal toxicity. N-methylmorpholine induced anophthalmia, internal hydrocephalus, and hydronephrosis but only at one dose which was also maternotoxic. Teratogenesis Carcinog. Mutagen. 19:369-376, 1999.
Sitarek
K
K
Department of Toxicology and Carcinogenesis, The Nofer Institute of Occupational Medicine, Lodz, Poland.
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D000853:Anophthalmos / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006849:Hydrocephalus / Q000139:chemically induced; D006869:Hydronephrosis / Q000139:chemically induced; D008098:Litter Size / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D009025:Morpholines / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens
D009025:Morpholines; D013723:Teratogens; C038816:4-methylmorpholine