The primate lentivirus-encoded Nef protein can regulate several steps of the viral replication cycle.
The primate lentiviruses encode a protein, Nef, which is required for efficient viral replication in their host. Several biological activities of nef identified in vitro may contribute to this requirement in vivo, including receptor modulation and interference with cellular signaling pathways. We show that HIV- and SIV-encoded Nef can enhance virus production within a single viral replication cycle, not only by increasing viral infectivity, as previously reported, but also by acting through the efficiency of viral transcription and of viral release.
Collette
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Y
Université de la Méditerranée, Marseille, 13009, France. collette@marseille.inserm.fr
Olive
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D
D000818:Animals; D015683:Gene Products, gag / Q000096:biosynthesis; D015693:Gene Products, nef / Q000235:genetics / Q000502:physiology*; D006678:HIV / Q000502:physiology*; D016655:HIV Core Protein p24 / Q000096:biosynthesis; D006367:HeLa Cells; D006801:Humans; D011323:Primates; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014758:Viral Core Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000502:physiology*; D054311:nef Gene Products, Human Immunodeficiency Virus
D015683:Gene Products, gag; D015693:Gene Products, nef; D016655:HIV Core Protein p24; D014758:Viral Core Proteins; D054311:nef Gene Products, Human Immunodeficiency Virus