Effect of the methanolic extract of Glinus lotoides on Dalton's ascitic lymphoma.
The antitumour activity of the methanolic extract of Glinus lotoides (MGL) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean survival time of tumour bearing mice and peritoneal cell count in normal mice was observed with respect to the control group. When these MGL treated animals underwent i.p. inoculation with DAL cells, tumour cell growth was found to be inhibited. After 14 d of inoculation, MGL is able to reverse the changes in the haemotological parameters, protein and packed cellular volume consequent to tumour inoculation.
Kavimani
S
S
Department of Pharmacology, Periyar College of Pharmaceutical Sciences for Girls, Tiruchirappalli-21 Tamil Nadu, India.
Manisenthilkumar
K T
KT
Ilango
R
R
Krishnamoorthy
G
G
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D001201:Ascites / Q000188:drug therapy; D001772:Blood Cell Count / Q000187:drug effects; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D016019:Survival Analysis
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts