Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.
Accelerated nodulosis (AN) is a potential complication of methotrexate (MTX) therapy for rheumatoid arthritis (RA). We report on a 62-year old man affected by seropositive RA who developed AN after five months of MTX treatment. MTX-dose reduction was followed by rapid regression of the skin nodules. The Authors describe the typical features of AN and discuss on the pathogenetic mechanisms.
Filosa
G
G
Division of Dermatology, A. Murri Hospital Jesi (An), Italy. gfilos@tin.it
Salaffi
F
F
Bugatti
L
L
D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012218:Rheumatoid Nodule / Q000139:chemically induced*
D018501:Antirheumatic Agents; D008727:Methotrexate