title: Myocardial mechanics, energetics, and hemodynamics during intraaortic balloon and transvalvular axial flow hemopump support with a bovine model of ischemic cardiac dysfunction.
abstract: Unlike the mechanisms of intraaortic balloon pump (IABP) support, the mechanisms by which transvalvular axial flow Hemopump (HP) support benefit dysfunctional myocardium are less clearly understood. To help elucidate these mechanisms, hemodynamic, metabolic, and mechanical indexes of left ventricular function were measured during conditions of control, ischemic dysfunction, IABP support, and HP support. A large animal (calf) model of left ventricular dysfunction was created with multiple coronary ligations. Peak intraventricular pressure increased with HP support and decreased with IABP support. Intramyocardial pressure (an indicator of intramyocardial stress), time rate of pressure change (an indicator of contractility), and left ventricular myocardial oxygen consumption decreased with IABP and HP support. Left ventricular work decreased with HP support and increased with IABP support. During HP support, indexes of wall stress, work, and contractility, all primary determinants of oxygen consumption, were reduced. During IABP support, indexes of wall stress and contractility were reduced and external work increased. These changes were attributed primarily to changes in ventricular preload, and geometry for HP support, and to a reduction in afterload for IABP support. These findings support the hypothesis that both HP and IABP support reduce intramyocardial stress development and the corresponding oxygen consumption, although via different mechanisms.
authors.affiliation: Institute for Biomedical Engineering, University of Utah, Salt Lake City 84103, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Marks
authors.forename: G M
authors.initials: GM
authors.lastname: Pantalos
authors.forename: J W
authors.initials: JW
authors.lastname: Long
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: S D
authors.initials: SD
authors.lastname: Everett
authors.forename: D B
authors.initials: DB
authors.lastname: Olsen
mesh_terms: D000818:Animals; D002417:Cattle; D003326:Coronary Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006351:Heart Valves / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D007423:Intra-Aortic Balloon Pumping; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D013718:Tensile Strength; D018487:Ventricular Dysfunction, Left / Q000378:metabolism / Q000503:physiopathology*