Determination of oxytetracycline in bovine kidney and medicated milk replacer by liquid chromatography.
Improvements and optimization of AOAC INTERNATIONAL Official Method 995.09 for the detection of oxytetracycline in bovine kidney at the new U.S. tolerance of 12 ppm are reported. Recoveries from kidney fortified at 4 concentrations over the range of 3-40 ppm averaged 84-98%. Results from the kidney of a calf fed medicated milk replacer containing oxytetracycline are also reported. Additionally, adaptation of this method to the detection of oxytetracycline in medicated milk replacer is discussed.
Kijak
P J
PJ
U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD 20708, USA.
Cope
C V
CV
Pedersoli
W M
WM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002417:Cattle; D002853:Chromatography, Liquid / Q000379:methods; D004032:Diet; D005503:Food Additives / Q000032:analysis; D007668:Kidney / Q000737:chemistry*; D008892:Milk / Q000737:chemistry*; D010118:Oxytetracycline / Q000032:analysis*
D000900:Anti-Bacterial Agents; D005503:Food Additives; D010118:Oxytetracycline