Designing secondary structures: 5-azidomethyl tetrahydrofuran-2-carboxylates as carbohydrate-derived dipeptide isosteres.
The potential of carbohydrate-like tetrahydrofuran frameworks as building blocks with predictable conformational propensities useful in the design and synthesis of novel peptidomimetic materials which adopt well-defined secondary structures is discussed.
Smith
M D
MD
University of Oxford, The Dyson Perrins Laboratory, Oxford Centre for Molecular Sciences, UK.
Fleet
G W
GW
D000596:Amino Acids / Q000737:chemistry; D001671:Biochemistry / Q000379:methods; D002241:Carbohydrates / Q000737:chemistry; D015195:Drug Design; D005663:Furans / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology; D017433:Protein Structure, Secondary
D000596:Amino Acids; D002241:Carbohydrates; D005663:Furans; D010455:Peptides; C018674:tetrahydrofuran