title: Salt water promotes hypertension in Dahl-S rats.
abstract: Hypertension was induced in Dahl-salt-sensitive (Dahl-S) rats by administering salt in drinking water. Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney. Rats receiving 0.5% NaCl solution developed moderate hypertension and renal lesions. Rats receiving 1.0% NaCl solution showed prominent and increasing hypertension and severe renal damage. This method of salt administration should be simpler than administration in the diet as a means of promoting renal hypertension. The lower concentration salt water caused chronic mild hypertension in Dahl-S rats, and may serve as a useful model for progressive hypertension.
authors.affiliation: Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Miura
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Hamada
authors.forename: R
authors.initials: R
authors.lastname: Kamimura
authors.forename: M
authors.initials: M
authors.lastname: Fujiki
authors.forename: K
authors.initials: K
authors.lastname: Misumi
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006321:Heart / Q000187:drug effects; D006977:Hypertension, Renal / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D020303:Rats, Inbred Dahl; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D012965:Sodium Chloride