Synthesis and evaluation of an aromatic polymer-coated zirconia for reversed-phase liquid chromatography.
We synthesized a novel aromatic polymer-coated zirconia-based RPLC stationary phase by chemical adsorption of a copolymer of chloromethylstyrene and diethoxymethylvinylsilane onto zirconia (CMS/VMS-ZrO2). Characterization of the pore structure of the support by nitrogen porosimetry and inverse size-exclusion chromatography indicates that CMS/VMS-ZrO2 maintains the well-defined pore structure of the base material. Flow studies show that CMS/VMS-ZrO2 has good mass transfer characteristics. The reversed-phase retention characteristics of the new support are comparable to those of conventional silica-bonded phases. We have also evaluated the mechanical, thermal, and pH stability of CMS/VMS-ZrO2. The results show that CMS/VMS-ZrO2 is stable over a very wide range of pH (pH = 1-13) and at temperatures as high as 160 degrees C. Chromatographic separations of some low molecular weight aromatic analytes on CMS/VMS-ZrO2 and octadecyl-bonded silica phases indicate that there are some subtle but significant differences in the chromatographic selectivity of these two types of phases.
Zhao
J
J
Department of Chemistry, University of Minnesota, Minneapolis 55455, USA.
Carr
P W
PW
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D011108:Polymers; D015040:Zirconium
D011108:Polymers; D015040:Zirconium; C028541:zirconium oxide