title: Usefulness of the epithelial tumor marker CA-125 in non-Hodgkin's lymphoma.
abstract: CA-125, a commonly used tumor marker for epithelial ovarian cancer, is a glycoprotein found in normal tissues derived from coelomic epithelia. Increased serum levels of CA-125 have also been found in nongynecologic tumors and nonmalignant diseases involving the peritoneum. A few recent studies and sporadic case reports have reported increased CA-125 levels in patients with non-Hodgkin's lymphoma (NHL). In our study, we aimed to evaluate the serum levels of CA-125 in patients with NHL and determine its potential role to show disease activity in NHL. Serum levels of CA-125 were measured in 61 patients with NHL and were found to be correlated with clinical stage, site of involvement, and disease activity.
authors.affiliation: Department of Internal Medicine, Cerrahpasa School of Medicine, Istanbul University, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozgüroglu
authors.forename: H
authors.initials: H
authors.lastname: Turna
authors.forename: G
authors.initials: G
authors.lastname: Demir
authors.forename: A
authors.initials: A
authors.lastname: Döventas
authors.forename: F
authors.initials: F
authors.lastname: Demirelli
authors.forename: N M
authors.initials: NM
authors.lastname: Mandel
authors.forename: E
authors.initials: E
authors.lastname: Büyükünal
authors.forename: S
authors.initials: S
authors.lastname: Serdengeçti
authors.forename: B
authors.initials: B
authors.lastname: Berkarda
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology; D018394:CA-125 Antigen / Q000032:analysis / Q000097:blood*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis; D010532:Peritoneal Diseases / Q000175:diagnosis; D011446:Prospective Studies; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D006023:Glycoproteins; D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase