title: Management of testicular seminoma.
abstract: Testicular seminoma is highly curable with currently available treatments. Today, there is good evidence that patients with Stage I disease can be treated equally well with either immediate adjuvant para-aortic and ipsilateral pelvic radiotherapy or close surveillance with treatment at the time of relapse. The decision as to which of these management strategies is adopted in an individual case is a complex function of physician preference, and the emotional, social, and economic circumstances of the patient. Ongoing research in Stage I seminoma is focused at reducing the side-effects of treatment either by modifying the radiation treatment plan or by using adjuvant chemotherapy in lieu of radiation. Stage II patients with small bulk retroperitoneal lymphadenopathy have a high probability of long-term disease control with radiotherapy. Patients with bulky Stage II disease or Stage III disease should be treated with cisplatin-based chemotherapy.
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital and the University of Toronto, Canada. mike_milosevic@pmh.toronto.on.ca
authors.forename: M F
authors.initials: MF
authors.lastname: Milosevic
authors.forename: M
authors.initials: M
authors.lastname: Gospodarowicz
authors.forename: P
authors.initials: P
authors.lastname: Warde
mesh_terms: D000704:Analysis of Variance; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D019370:Observation / Q000379:methods; D009919:Orchiectomy; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D018239:Seminoma / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016019:Survival Analysis; D015996:Survival Rate; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome