title: Facial nerve pathology in leprosy: searching for the proximal extent of the lesion in facial nerve biopsies.
abstract: A light and electron microscope study was made of resin embedded facial nerves in three cases of leprosy involving the facial nerve. The patients had irreversible facial nerve palsies and had requested facial reconstruction. No consistent pattern of nerve fibre damage was found. In one case the temporozygomatic was affected, but the cervical branch was normal, suggesting the damage begins distally. In two cases the loss of nerve fibres in the trunk and all branches was similar, and is likely to emanate from damage at a more proximal site. The presence of increased numbers of unmyelinated axons, often in clusters, is evidence of regeneration. These axons probably have the potential to develop into functional myelinated fibres provided that they can innervate a viable distal target such as a muscle graft. These regenerating axons are distal to the stylomastoid foramen suggesting that the most proximal level of involvement of the facial nerve could be intracranial. The finding of a more proximal level of nerve involvement, implies that the mis-reinnervation seen in partially recovered facial nerve palsies in leprosy, could be due to some regenerating axons being mis-directed at the level of the main trunk bifurcation.
authors.affiliation: Green Pastures Hospital, Pokhara, Nepal.
authors.forename: B M
authors.initials: BM
authors.lastname: Richard
authors.forename: J M
authors.initials: JM
authors.lastname: Jacobs
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D005154:Facial Nerve / Q000473:pathology*; D005158:Facial Paralysis / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D015439:Leprosy, Borderline / Q000473:pathology* / Q000601:surgery; D015441:Leprosy, Tuberculoid / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019651:Plastic Surgery Procedures; D012720:Severity of Illness Index; D016896:Treatment Outcome