Effect of formulation variables on cis-platin loaded chitosan microsphere properties.
Chitosan microspheres containing cis-platin were prepared using a w/o emulsion system. Variables important for microsphere properties were investigated: these include; chitosan, cis-platin and glutaraldehyde concentrations, the types of chitosan and oil, the cross-linking process and stirring rate. Chitosan and glutaraldehyde concentrations, the types of oil and chitosan have a significant effect on cis-platin entrapment in chitosan microspheres. In general, incorporation efficiency was high and ranged from 28-99%. The type and concentration of chitosan affected cis-platin release from microspheres. The type of oil was also important for release properties. Cis-platin release from microspheres is characterized by an initial burst effect.
Akbuğa
J
J
Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Turkey.
Bergişadi
N
N
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan; D002945:Cisplatin / Q000138:chemical synthesis* / Q000737:chemistry*; D003432:Cross-Linking Reagents; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D013997:Time Factors
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D002686:Chitin; D048271:Chitosan; D002945:Cisplatin