title: Accumulation of plasma reduced folates after folic acid administration.
abstract: The pharmacokinetics of folic acid, and resultant metabolites thereof, have been determined after administration orally and intravenously at 25 mg/m2 and 125 mg/m2. Saturation behavior was observed for uptake of folic acid into plasma and with regard to metabolism to methylenetetrahydrofolate and tetrahydrofolate as well as methyltetrahydrofolate. Repetitive oral administration every 6 hours resulted in consistently elevated levels of each metabolite pool with the same general saturation behavior as observed with single dose administration. This repetitive oral administration is concluded to be a suitable means to provide uniform elevation of metabolites that could offer protection from undesirable toxic effects of drugs such as MTA.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Priest
authors.forename: J C
authors.initials: JC
authors.lastname: Schmitz
authors.forename: M A
authors.initials: MA
authors.lastname: Bunni
mesh_terms: D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous
chemical_list: D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D005492:Folic Acid