title: Selectin-carbohydrate interactions in shear flow.
abstract: Hydrodynamic shear creates mechanical stresses on selectin bonds, modulating affinity and kinetic parameters. Chemical modification of sialyl Lewis(x) increases the strength of L-selectin bonds without altering recognition, suggesting that mechanical and biorecognition characteristics are separable. L-selectin bond formation rates may be strongly influenced by sulfate orientation in sulfo sialyl Lewis(x).
authors.affiliation: Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Box 377, Charlottesville, VA 22908, USA. mbl2a@virginia.edu.
authors.forename: M B
authors.initials: MB
authors.lastname: Lawrence
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D012212:Rheology; D019087:Selectins / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D008024:Ligands; D019087:Selectins