Multipoint linkage analysis using the weighted-pairwise correlation statistic.
The weighted pairwise correlation (WPC) approach provides simple and flexible non-parametric tests for genetic linkage which may be adapted to qualitative, quantitative or age-dependent traits. Although this statistic has often been used with identity-by-state (IBS) information, there is much to gain by using multipoint identity-by-descent (IBD) information. The purpose of this paper is to use the unified multipoint approach of Kruglyak et al. [1996] with the WPC statistic. We used the simulated data of a complex disease proposed in GAW11 (problem 2) to validate this approach and to compare the multipoint WPC to the IBS-WPC and to the multilocus approach using the conventional non-parametric statistics S(pairs) and S(all). The results suggest that the multipoint WPC may be the most powerful approach.
Commenges
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INSERM U330, Université de Bordeaux II, France.
Beurton-Aimar
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D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D012984:Software; D018709:Statistics, Nonparametric