title: Thin-section CT findings in rheumatoid arthritis-associated lung disease: CT patterns and their courses.
abstract: OBJECTIVE
  The purpose of this study was to describe the long-term follow-up CT evaluation in rheumatoid arthritis (RA)-associated lung disease.
  
  
  METHODS
  Thin-section CT scans from 29 patients with RA and suspected associated lung disease were reviewed. Twenty-two patients underwent sequential CT evaluation during 3 to 108 months of follow-up (mean 28 months). Histologic comfirmation of pulmonary involvement was available in 19 patients.
  
  
  RESULTS
  Three major patterns were identified: reticulation with or without honey-combing (n = 19), centrilobular branching lines with or without bronchial dilatation (n = 5), and consolidation (n = 5). Reticulation and centrilobular branching lines corresponded to usual interstitial pneumonia (n = 14) and bronchiolitis obliterans (n = 1), respectively. Consolidation corresponded to bronchiolitis obliterans organizing pneumonia (BOOP; n = 3) and coexistent chronic eosinophilic pneumonia (CEP) and BOOP (n = 1). Patients with reticulation had rapid deterioration when there was new appearance of multifocal areas of ground-glass attenuation. Centrilobular branching lines progressed to bronchiectasis in one case. There was mild progression of existing bronchiectasis associated with centrilobular branching lines in one case. Area of consolidation in two patients with BOOP and one with coexistent CEP and BOOP evolved into honeycombing at serial CT.
  
  
  CONCLUSIONS
  Thin-section CT is a noninvasive technique for monitoring disease morphology in RA-associated lung disease. Initial CT findings and their evolution on sequential examinations may be useful in evaluating prognosis.
authors.affiliation: Department of Radiology, National Kinki Chuo Hospital for Chest Disease, Sakai City, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akira
authors.forename: M
authors.initials: M
authors.lastname: Sakatani
authors.forename: H
authors.initials: H
authors.lastname: Hara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001987:Bronchiectasis / Q000000981:diagnostic imaging / Q000209:etiology; D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging / Q000209:etiology; D002908:Chronic Disease; D018549:Cryptogenic Organizing Pneumonia / Q000000981:diagnostic imaging / Q000209:etiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging / Q000209:etiology; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*