title: Application of pharmacogenetics to optimization of mercaptopurine dosing.
authors.forename: F M
authors.initials: FM
authors.lastname: Balis
authors.forename: P C
authors.initials: PC
authors.lastname: Adamson
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation; D005838:Genotype; D006150:Guanine Nucleotides; D006801:Humans; D015122:Mercaptopurine / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D008745:Methylation; D008780:Methyltransferases / Q000235:genetics; D010597:Pharmacogenetics; D011355:Prodrugs / Q000008:administration & dosage* / Q000378:metabolism* / Q000493:pharmacokinetics; D013873:Thionucleotides
chemical_list: D000964:Antimetabolites, Antineoplastic; D006150:Guanine Nucleotides; D011355:Prodrugs; D013873:Thionucleotides; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase