Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region.
We report the identification of a new transcript homologous to the Drosophila staufen protein. This transcript, named STAU2 (HGMW-approved gene symbol and name), maps to the chromosome 8q13-q21 region. The full-length STAU2 cDNA is 4058 bp and contains an open reading frame of 479 amino acids. Analysis of the predicted protein product indicated the presence of three double-stranded RNA-binding domains. Best-fit analysis revealed a 48.5% similarity to the Drosophila protein and a 59.9% similarity to the recently described mammalian homolog hStau, indicating that at least two different transcripts with homologies to the fly protein are present in mammals.
Buchner
G
G
Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy.
Bassi
M T
MT
Andolfi
G
G
Ballabio
A
A
Franco
B
B
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D020224:Expressed Sequence Tags; D020440:Gene Duplication; D015870:Gene Expression; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D008322:Mammals / Q000235:genetics; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017434:Protein Structure, Tertiary; D012313:RNA / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics*; D016415:Sequence Alignment; D017385:Sequence Homology; D013045:Species Specificity
D018076:DNA, Complementary; D029721:Drosophila Proteins; D016601:RNA-Binding Proteins; C069927:stau protein, Drosophila; D012313:RNA