Effect of linear alkylbenzene sulphonate on topical absorption of chromium and nickel.
The effect of the topical applications of linear alkylbenzene sulphonate (LAS), or chromium (Cr) + nickel (Ni), or the combination of LAS + Cr + Ni for 30 d were investigated. Increased activities of aspartate amino transferase, alanine amino transferase, acid phosphatase and gamma glutamyl transpeptidase and decreased activity of superoxide dismutase occurred. Increased lipid peroxidation and decreased glutathione were observed. Accumulation of Cr and Ni increased in tissues. Biochemical alterations and metal accumulations were more marked in the Cr + Ni + LAS group.
Mathur
A K
AK
Industrial Toxicology Research Centre, Lucknow, India.
Gupta
B N
BN
D000476:Alkanesulfonates / Q000494:pharmacology*; D000818:Animals; D002857:Chromium / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009532:Nickel / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000187:drug effects*
D000476:Alkanesulfonates; D002857:Chromium; D009532:Nickel; D005978:Glutathione