Rhodopeptins (Mer-N1033), novel cyclic tetrapeptides with antifungal activity from Rhodococcus sp. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
Five novel cyclic tetrapeptides, named rhodopeptin C1, C2, C3, C4 and B5, were isolated from a strain named Rhodococcus sp. Mer-N1033. They are a novel type of cyclic tetrapeptide composed of a beta-amino acid and three usual alpha-amino acids. Rhodopeptins show high in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, whereas they show no activity against bacteria.
Chiba
H
H
Process Development Laboratories, Mercian Corporation, Iwata-shi, Shizuoka, Japan.
Agematu
H
H
Kaneto
R
R
Terasawa
T
T
Sakai
K
K
Dobashi
K
K
Yoshioka
T
T
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D007939:Leukemia L1210 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*; D012240:Rhodococcus / Q000145:classification* / Q000378:metabolism*
D000935:Antifungal Agents; D010456:Peptides, Cyclic; C401441:rhodopeptin B5; C401214:rhodopeptin C1; C401215:rhodopeptin C2; C401216:rhodopeptin C3; C401217:rhodopeptin C4