[Effects of tibolone on lipid and glucose metabolism as well as insulin secretion in postmenopausal women].
Tibolone is a synthetic steroid with progestogenic, androgenic and estrogenic properties. In postmenopausal women it has been shown that improves climateric complaints and prevents osteoporosis, without impact on endometrial thickness and uterine fibroids volume. Tibolone administration decreases cholesterol and triglycerides. Although, the effects of hormonal replacement on insulin sensitivity and glucose metabolism has not been well established. The effect of tibolone 2.5 mg/day for 3 months was investigated in 10 healthy postmenopausal women. The results show that tibolone decreases tryglicerides and cholesterol levels along with an increase in fasting insulin levels. The oral glucose tolerance test was unaffected. This study suggests that tibolone reduces markers of cardiovascular disease.
Villanueva
L A
LA
Hospital General Dr. Manuel Gea González, La Habana, Cuba.
Ortega
R
R
Morimoto
S
S
Villanueva
S
S
Arranz
C
C
D045930:Anabolic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050356:Lipid Metabolism; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology / Q000627:therapeutic use*; D017698:Postmenopause / Q000187:drug effects*; D011372:Progestins / Q000494:pharmacology / Q000627:therapeutic use*
D045930:Anabolic Agents; D007328:Insulin; D009652:Norpregnenes; D011372:Progestins; C027385:tibolone; D005947:Glucose
Efectos de la tibolona sobre el metabolismo de lípidos, glucosa y secreción de insulina en mujeres posmenopáusicas.