title: Bronchodilator responsiveness and serum total IgE levels in families of probands with severe early-onset COPD.
abstract: Bronchodilator responsiveness has been associated with a subsequent accelerated decline in forced expiratory volume in one second (FEV1). Therefore, bronchodilator responsiveness and total serum immunoglobulin E(IgE) levels were assessed in 184 adult first-degree relatives of probands with severe early-onset chronic obstructive pulmonary disease (COPD) and a control group. Greater bronchodilator responsiveness was found among current smokers or exsmokers who were first-degree relatives of early-onset COPD probands than in currently or exsmoking controls, expressed as increase in FEV1 as a percentage of baseline (5.8+/-8.1 versus 2.9+/-5.1%, p<0.01), absolute increase in FEV1 from baseline (120+/-130 versus 60+/-110 mL, p<0.05), and increase in FEV1 as a percentage of the predicted value (3.6:4.1 versus 2.2+/-3.9%, p<0.05). However, elevated total serum IgE levels were not found in first-degree relatives of early-onset COPD probands compared with control subjects. The increased bronchodilator responsiveness among currently smoking/exsmoking first-degree relatives of early-onset COPD probands suggests that these individuals may have enhanced susceptibility to the detrimental effects of cigarette smoking.
authors.affiliation: Channing Laboratory, Dept of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Celedon
authors.forename: F E
authors.initials: FE
authors.lastname: Speizer
authors.forename: J M
authors.initials: JM
authors.lastname: Drazen
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
authors.forename: E J
authors.initials: EJ
authors.lastname: Campbell
authors.forename: V J
authors.initials: VJ
authors.lastname: Carey
authors.forename: J J
authors.initials: JJ
authors.lastname: Reilly
authors.forename: L
authors.initials: L
authors.lastname: Ginns
authors.forename: E K
authors.initials: EK
authors.lastname: Silverman
mesh_terms: D000328:Adult; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000502:physiology*; D016022:Case-Control Studies; D005190:Family; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008173:Lung Diseases, Obstructive / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D012907:Smoking / Q000503:physiopathology; D013147:Spirometry
chemical_list: D007073:Immunoglobulin E