Serotonin-2A receptor polymorphism (102T/C) in mood disorders
Serotonergic dysfunction has been implicated in mood disorders and suicidal behaviors. This study examined the association between a serotonin-2A (5HT2A) receptor gene polymorphism (102T/C) and mood disorders. The genotype and allele frequencies did not differ between patients with mood disorders and control subjects. Furthermore, the 102T/C polymorphism was not found to be associated with suicidal history in mood disorder patients. Our results suggest that this polymorphism is unlikely to play a role in the genetic susceptibility to mood disorders.
Tsai
SJ
Department of Psychiatry, Veterans General Hospital-Taipei, School of Medicine, National Yang-Ming University, Taiwan, ROC.
Hong
CJ
Hsu
CC
Cheng
CY
Liao
WY
Song
HL
Lai
HC