Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance.
Saccharomyces cerevisiae was the first eukaryotic organism whose complete genome sequence has been determined, uncovering the existence of numerous genes encoding proteins of the ATP-binding cassette (ABC) family. Fungal ABC proteins are implicated in a variety of cellular functions, ranging from clinical drug resistance development, pheromone secretion, mitochondrial function, peroxisome biogenesis, translation elongation, stress response to cellular detoxification. Moreover, some yeast ABC proteins are orthologues of human disease genes, which makes yeast an excellent model system to study the molecular mechanisms of ABC protein-mediated disease. This review provides a comprehensive discussion and update on the function and transcriptional regulation of all known ABC genes from yeasts, including those discovered in fungal pathogens.
Bauer
B E
BE
Department of Molecular Genetics, University and Bio Center of Vienna, Dr. Bohr-Gasse 9/2, A-1030, Vienna, Austria.
Wolfger
H
H
Kuchler
K
K
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D000074063:ATP Binding Cassette Transporter, Subfamily D, Member 1; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000935:Antifungal Agents / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010445:Peptide Elongation Factors / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000074063:ATP Binding Cassette Transporter, Subfamily D, Member 1; D018528:ATP-Binding Cassette Transporters; D000935:Antifungal Agents; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010445:Peptide Elongation Factors; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C115572:ABCD1 protein, human; C085480:PDR1 protein, S cerevisiae; C089261:PDR3 protein, S cerevisiae; C086677:YAP1 protein, S cerevisiae; C111584:YEF3 protein, S cerevisiae