Meta-analysis of linkage studies.
Lander and Kruglyak [1995] gave guidelines for interpreting linkage results based on estimating how often a particular threshold for significance would be exceeded by chance in a single genome scan. What is unknown is how often two or more genome scans would exceed a particular threshold within the same region. We develop theoretical estimates of these values and compare these with the empirical estimates derived from the GAW11 data. For single-point analysis, the theoretical estimates predict the empirical estimates. For multipoint analysis, the theoretical values overestimate what is observed. For both single point and multipoint, modest p-values within a single genome scan may give highly significant results when replicated in the same region in other scans.
Badner
J A
JA
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Goldin
L R
LR
D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D015201:Meta-Analysis as Topic; D008957:Models, Genetic