title: Intermittent noise-induced hearing loss and the influence of carbon monoxide.
abstract: Intermittent noise causes less hearing loss than continuous noise of equal intensity. The reduction in damage observed with intermittent noise may be explained by the fact that the auditory system has time to recover between the noise phases. Simultaneous carbon monoxide (CO) exposure produces greater noise-induced hearing loss than does noise alone (Chen and Fechter, 1999). In the present study, intermittent noise (octave-band with a center frequency of 13.6 kHz, 100 dB) of a 2 h total duration but with a different duty cycle (% of noise during exposure) was used. The intermittent exposure that had a shorter noise duty cycle induced a less permanent threshold shift (PTS) than those that had a longer noise duty cycle (or less rest periods). This relation between the loss in compound action potential (CAP) sensitivity and the noise duty cycle (or rest period) was abolished by the presence of CO. The cochlear microphonic (CM) amplitude revealed similar results to those seen using the CAP. While intermittent noise that had a short noise duty cycle did not cause hair cell loss by itself, the combined exposure to noise and CO (1200 ppm) caused remarkable OHC loss in the basal turn.
authors.affiliation: University of Oklahoma, Health Sciences Center, College of Pharmacy, 1110 N. Stonewall, Oklahoma City, OK 73190, USA. guangdi-chen@ouhsc.edu
authors.forename: G D
authors.initials: GD
authors.lastname: Chen
authors.forename: M L
authors.initials: ML
authors.lastname: McWilliams
authors.forename: L D
authors.initials: LD
authors.lastname: Fechter
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D002248:Carbon Monoxide / Q000494:pharmacology; D002452:Cell Count / Q000187:drug effects; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D018072:Hair Cells, Auditory, Outer / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D002248:Carbon Monoxide