Generation of recombinant antibodies.
Recombinant antibody technology is opening new perspectives for the development of novel therapeutic and diagnostic agents. In this review we focus on advances in the generation of both genetically engineered humanized and fully human monoclonal antibodies. Methods for their production in different expression systems are also discussed.
Kipriyanov
S M
SM
Recombinant Antibody Research Group, German Cancer Research Center, Heidelberg, Germany.
Little
M
M
D000818:Animals; D000917:Antibody Formation; D017104:Bacteriophage M13; D016466:CHO Cells; D019556:COS Cells; D006224:Cricetinae; D004926:Escherichia coli / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D018506:Gene Expression Regulation, Plant; D006801:Humans; D007128:Immunoglobulin Fragments; D018448:Models, Immunological; D008958:Models, Molecular; D019151:Peptide Library; D011994:Recombinant Proteins / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
D007128:Immunoglobulin Fragments; D019151:Peptide Library; D011994:Recombinant Proteins