Cytokines and JAK-STAT signaling.
Characterization of the ability of IFNs to induce immediate early genes led to the identification of the STAT (signal transducers and activators of transcription) signaling paradigm. STATs are activated at the receptor and then directly transduce signals to the nucleus. Subsequent studies have determined that all cytokines transduce critical signals through this pathway.
Schindler
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Columbia University, 701 W. 168th Street, HHSC-1212, New York, New York, 10032, USA. cws4@columbia.edu
D016207:Cytokines / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007372:Interferons / Q000378:metabolism; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism*
D016207:Cytokines; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D007372:Interferons; D011505:Protein-Tyrosine Kinases