title: Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.
abstract: We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.
authors.affiliation: Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK. mmc18f@clinmed.gla.ac.uk
authors.forename: M O
authors.initials: MO
authors.lastname: McCarron
authors.forename: K L
authors.initials: KL
authors.lastname: Hoffmann
authors.forename: D M
authors.initials: DM
authors.lastname: DeLong
authors.forename: L
authors.initials: L
authors.lastname: Gray
authors.forename: A M
authors.initials: AM
authors.lastname: Saunders
authors.forename: M J
authors.initials: MJ
authors.lastname: Alberts
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001929:Brain Edema / Q000235:genetics* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000235:genetics* / Q000401:mortality; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006406:Hematoma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E