title: Effect of dietary seal and fish oils on triacylglycerol metabolism in rats.
abstract: Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were distributed mainly in the sn-1 and 3 positions of seal oil triacylglycerol and in the sn-2 position of fish oil triacylglycerol. Seal oil or fish oil-rich fats having constant polyunsaturated/monounsaturated/saturated fatty acids and n-6/n-3 polyunsaturated fatty acid (PUFA) ratios were fed to rats for 3 wk. Control rats were fed on a fat containing linoleic acid as the sole PUFA. Seal oil more effectively lowered serum and liver triacylglycerol concentrations than fish oil. The activities of fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH) and hepatic triacylglycerol lipase (HTGL) were significantly lower in the seal oil group than in the control group, whereas the activity of HTGL was significantly lower and the hepatic peroxisomal beta-oxidation and activity of lipoprotein lipase (LPL) in adipose tissue were significantly higher in the fish oil group than in the control group. These observations suggest that the predominant hypotriacylglycerolemic effect of seal oil is caused by the suppression of fatty acid synthesis.
authors.affiliation: Laboratory of Nutrition Chemistry, Graduate School Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Mawatari
authors.forename: I
authors.initials: I
authors.lastname: Ikeda
authors.forename: K
authors.initials: K
authors.lastname: Imaizumi
authors.forename: A
authors.initials: A
authors.lastname: Seto
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
mesh_terms: D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000032:analysis / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000032:analysis; D015118:Eicosapentaenoic Acid / Q000032:analysis; D064429:Fatty Acid Synthases / Q000378:metabolism; D005395:Fish Oils / Q000032:analysis / Q000494:pharmacology; D006153:Guanosine Diphosphate / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D046048:Seals, Earless; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism; D014413:Tuna
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D014280:Triglycerides; D006153:Guanosine Diphosphate; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D064429:Fatty Acid Synthases; D008049:Lipase