title: The effect of age on pharmacokinetics of the local anesthetic drug articaine.
abstract: OBJECTIVE
  With increasing age, there are physiologic changes that could affect pharmacokinetics of drugs. More elderly patients are undergoing routine dental procedures for which local anesthesia could be required. The goal of the present study was to evaluate the effect of age on pharmacokinetics of the local anesthetic agent articaine.
  
  
  METHODS
  The submucosal infiltration anesthesia from two different dosages of 4% articaine without epinephrine was compared in healthy elderly and young volunteers. High performance liquid chromatography has been used to determine concentrations of articaine in serum. Basic pharmacokinetic parameters were calculated according to standard procedures using a two-exponent equation.
  
  
  RESULTS
  The clearance and volume of distribution (Vdss) of articaine after infiltration anesthesia were significantly lower in elderly volunteers compared with young volunteers. The area under the serum concentration-time curve and maximum drug concentration (Cmax) values did not differ significantly with age; however, both parameters tended to be higher in elderly volunteers. No changes in terminal half-life and time to reach maximum serum concentration (t(max)) were observed. The Cmax and tmax values of the metabolite articainic acid were similar in young and elderly volunteers. CONCLUSIONS The results show that the metabolism of articaine is age-independent in healthy male volunteers. The smaller Vdss in the elderly results in a trend to higher serum levels after a given dose of articaine. No change of dosage of articaine in elderly patients should be necessary.
authors.affiliation: Institute of Clinical Pharmacology, Faculty of Medicine, Technical University, Dresden, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Oertel
authors.forename: U
authors.initials: U
authors.lastname: Ebert
authors.forename: R
authors.initials: R
authors.lastname: Rahn
authors.forename: W
authors.initials: W
authors.lastname: Kirch
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000779:Anesthetics, Local / Q000097:blood / Q000493:pharmacokinetics*; D002355:Carticaine / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
chemical_list: D000779:Anesthetics, Local; D002355:Carticaine