Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions.
The peroxisome proliferator-activated receptors (PPARs) are fatty acid and eicosanoid inducible nuclear receptors, which occur in three different isotypes. Upon activator binding, they modulate the expression of various target genes implicated in several important physiological pathways. During the past few years, the identification of both PPAR ligands, natural and synthetic, and PPAR targets and their associated functions has been one of the most important achievements in the field. It underscores the potential therapeutic application of PPAR-specific compounds on the one side, and the crucial biological roles of endogenous PPAR ligands on the other.
Michalik
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L
Institut de Biologie Animale, Université de Lausanne, Lausanne, CH-1015, Switzerland.
Wahli
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D000818:Animals; D008024:Ligands; D011485:Protein Binding; D020033:Protein Isoforms / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology
D008024:Ligands; D020033:Protein Isoforms; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors