title: Membranoproliferative glomerulonephritis type I, mixed cryoglobulinemia and lymphoma in the absence of hepatitis C infection.
abstract: Chronic hepatitis C virus infection has been linked to cryoglobulinemia, membranoproliferative glomerulonephritis, and malignant B-cell lymphoproliferation, suggesting a possible pathogenetic link between these disorders. We report a patient with the latter clinical triad in the absence of hepatitis C infection. We postulate that the persistent and dysregulated immunologic activity associated with chronic antigen stimulation, inflammation and/or B-cell malignancy induces nephritogenic autoantibodies, including cryoglobulins, that produce a similar clinical syndrome in genetically susceptible individuals.
authors.affiliation: PENN Kidney Center and Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6144, USA.
authors.forename: S E
authors.initials: SE
authors.lastname: Rosas
authors.forename: J E
authors.initials: JE
authors.lastname: Tomaszewski
authors.forename: H I
authors.initials: HI
authors.lastname: Feldman
authors.forename: M H
authors.initials: MH
authors.lastname: Foster
mesh_terms: D001707:Biopsy, Needle; D003449:Cryoglobulinemia / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003937:Diagnosis, Differential; D005920:Glomerular Mesangium / Q000648:ultrastructure; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D005938:Glucocorticoids