Overdose of Rogaine Extra Strength for Men topical minoxidil preparation.
Minoxidil is a potent arterial vasodilator used in the treatment of hypertension. A side effect, hypertrichosis, has prompted the marketing of a topical preparation, Rogaine, for the treatment of male-pattern baldness. Recently, a 5% solution of minoxidil became available over-the-counter as Rogaine Extra Strength For Men Hair Regrowth Treatment. We describe an oral overdose of minoxidil 3 g as the Rogaine Extra Strength preparation. Toxicity manifested as profound hypotension, requiring vasopressor support, intubation, prolonged tachycardia, and fluid overload with pleural effusions, requiring several days of therapy with furosemide. This is the largest reported ingestion of minoxidil and the first reported overdose of the extra strength 5% solution.
Farrell
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SE
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. sfarrell@bidmc.harvard.edu
Epstein
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SK
D000284:Administration, Oral; D000328:Adult; D062787:Drug Overdose / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy; D008914:Minoxidil / Q000506:poisoning*; D004366:Nonprescription Drugs / Q000506:poisoning*; D010656:Phenylephrine / Q000627:therapeutic use; D013406:Suicide, Attempted; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000506:poisoning*
D004366:Nonprescription Drugs; D014665:Vasodilator Agents; D010656:Phenylephrine; D008914:Minoxidil; D005665:Furosemide