title: Refined physical mapping and genomic structure of the EXTL1 gene.
abstract: Recently, the EXTL1 gene, a member of the EXT tumor suppressor gene family, has been mapped to 1p36, a chromosome region which is frequently implicated in a wide variety of malignancies, including breast carcinoma, colorectal cancer and neuroblastoma. In this study, we show that the EXTL1 gene is located between the genetic markers D1S511 and D1S234 within 200 kb of the LAP18 gene on chromosome 1p36. 1, a region which has been proposed to harbor a tumor suppressor gene implicated in MYCN-amplified neuroblastomas. In addition, we determined the genomic structure of the EXTL1 gene, revealing that the EXTL1 coding sequence spans 11 exons within a 50-kb region.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Belgium. wwuyts@uia.ua.ac.be
authors.forename: W
authors.initials: W
authors.lastname: Wuyts
authors.forename: N
authors.initials: N
authors.lastname: Spieker
authors.forename: N
authors.initials: N
authors.lastname: Van Roy
authors.forename: K
authors.initials: K
authors.lastname: De Boulle
authors.forename: A
authors.initials: A
authors.lastname: De Paepe
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
authors.forename: W
authors.initials: W
authors.lastname: Van Hul
authors.forename: R
authors.initials: R
authors.lastname: Versteeg
authors.forename: F
authors.initials: F
authors.lastname: Speleman
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D002460:Cell Line; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D015179:Colorectal Neoplasms / Q000235:genetics; D005091:Exons; D005260:Female; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000166:cytology; D017351:N-Acetylglucosaminyltransferases; D017349:N-Acetylhexosaminyltransferases / Q000235:genetics*; D009447:Neuroblastoma / Q000235:genetics; D016366:Open Reading Frames; D025521:Tumor Suppressor Proteins
chemical_list: D005819:Genetic Markers; D025521:Tumor Suppressor Proteins; C121267:EXTL1 protein, human; D017351:N-Acetylglucosaminyltransferases; D017349:N-Acetylhexosaminyltransferases