title: A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
abstract: We have tested a new ligand for peroxisome proliferator-activated receptor-gamma, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the classic rat model with nitrosomethylurea as carcinogen. Rats were first treated with a single dose of nitrosomethylurea (50 mg/kg body weight, i.p.). Starting 1 week later, they were fed GW7845, at either 60 or 30 mg/kg of diet, for 2 months. This agent significantly reduced tumor incidence, tumor number, and tumor weight at both doses. This is the first report of the use of a ligand for peroxisome proliferator-activated receptor-gamma to prevent experimental breast cancer.
authors.affiliation: Department of Pharmacology and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
authors.forename: N
authors.initials: N
authors.lastname: Suh
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: C R
authors.initials: CR
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Risingsong
authors.forename: T
authors.initials: T
authors.lastname: Gilmer
authors.forename: T M
authors.initials: TM
authors.lastname: Willson
authors.forename: M B
authors.initials: MB
authors.lastname: Sporn
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008024:Ligands; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008770:Methylnitrosourea; D010080:Oxazoles / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013629:Tamoxifen / Q000627:therapeutic use; D014157:Transcription Factors / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D008024:Ligands; D010080:Oxazoles; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D013629:Tamoxifen; C401311:GW 7845; D014443:Tyrosine; D008770:Methylnitrosourea