Clinical presentation of fibrodysplasia ossificans progressiva: pitfalls in diagnosis.
A patient presented with a rapidly growing mass in the cervicothoracic paraspinous region. Associated clinical and radiographic skeletal abnormalities and histopathologic findings showing mild to moderate proliferation of spindle cells in a myxoid stroma led to the diagnosis of fibrodysplasia ossificans progressiva. Recognizing the clinical features of this disease is important and should avoid the need for obtaining tissue to make the diagnosis, because performing a biopsy may be particularly morbid in these patients.
Magryta
C J
CJ
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Kligora
C J
CJ
Temple
H T
HT
Malik
R K
RK
D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009221:Myositis Ossificans / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D010808:Physical Examination; D011859:Radiography; D012189:Retrospective Studies
D008775:Methylprednisolone