The importance of watching our weights: how the choice of weights for non-independent sib pairs can dramatically alter results.
Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.
Van Eerdewegh
P
P
Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA.
Dupuis
J
J
Santangelo
S L
SL
Hayward
L B
LB
Blacker
D
D
D000437:Alcoholism / Q000235:genetics*; D003198:Computer Simulation; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D015233:Models, Statistical; D009679:Nuclear Family; D012984:Software; D018709:Statistics, Nonparametric