Proteus syndrome: craniofacial and cerebral MRI.
The Proteus syndrome is a rare hamartoneoplastic syndrome that may affect the brain, skull, and extracranial head and neck. We present a case with severe, characteristic findings. Brain abnormalities are not common in Proteus syndrome; when present, hemimegalencephaly and migrational disorders are typically seen, commonly with an associated seizure disorder. Maxillary and mandibular dysmorphism may occur, including unilateral condylar hyperplasia. Subcutaneous fatty, fibrous, lymphangiomatous masses commonly seen in this syndrome may involve the neck and face, leading to disfigurement and potential airway compromise.
DeLone
D R
DR
Department of Radiology, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792-3252, USA.
Brown
W D
WD
Gentry
L R
LR
D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008202:Lymphangioma / Q000175:diagnosis / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008334:Mandible / Q000002:abnormalities; D008335:Mandibular Condyle / Q000002:abnormalities; D008437:Maxilla / Q000002:abnormalities; D016715:Proteus Syndrome / Q000175:diagnosis* / Q000473:pathology