p-Chloroamphetamine (PCA) suppresses ingestive behavior in male rats.
Ingestive behavior was activated in male rats by intraoral intake and intake from a bottle of 1-M solution of sucrose. Intraperitoneal injection of p-chloroamphetamine (PCA), releasing central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals, inhibited ingestion of the sucrose solution. Significant inhibition of sucrose intake by PCA was observed at 1.25 and 2.5 mg/kg dose in a bottle intake test, and at 5.0 mg/kg dose in an intraoral intake test. These findings suggested that 1.25 and 5.0 mg/kg of PCA suppressed appetitive ingestive behavior and consummatory ingestive behavior in male rats, respectively.
Saito
T R
TR
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Saito
M
M
Arai
T
T
Aokikomori
S
S
Taniguchi
K
K
Takahashi
K W
KW
D000284:Administration, Oral; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018490:Serotonin Agents / Q000494:pharmacology*; D013395:Sucrose / Q000008:administration & dosage; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D018490:Serotonin Agents; D013395:Sucrose; D010133:p-Chloroamphetamine