title: Should gynecologic maturity change the management of cervical cytologic atypia during adolescence?
abstract: OBJECTIVE
  To test the hypothesis that atypical cytology (ASCUS) portends ominous histologic diagnoses during adolescence.
  
  
  METHODS
  The prevalence of squamous intraepithelial lesions (SILs) was determined in a racially diverse group of thirty-six 14- to 21-year-olds who were undergoing colposcopic evaluation of ASCUS cytology. The prevalence of 10 widely accepted risk factors for SIL was also qualified.
  
  
  RESULTS
  SILs were detected in biopsies obtained from 20 (56%) of the 36 study subjects. There were 15 (39%) low-grade SILs and 5 (17%) high-grade SILs. No single risk factor or combination of risk factors distinguished subjects with SIL histology from those with more benign diagnoses.
  
  
  CONCLUSIONS
  The hypothesis was supported. More than half (56%) of the adolescents we studied with ASCUS cytology had SIL histology. The findings suggest that immediate colposcopic evaluation may be prudent for adolescents with ASCUS cytology that cannot be attributed to concurrent lower genital tract infections.
authors.affiliation: Department of Pediatrics, University of Colorado Health Science Center, Denver, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kelly
authors.forename: A
authors.initials: A
authors.lastname: Bleistein
authors.forename: C
authors.initials: C
authors.lastname: Stevens-Simon
mesh_terms: D000293:Adolescent; D000295:Adolescent Medicine / Q000379:methods; D000328:Adult; D000367:Age Factors; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology; D015331:Cohort Studies; D003127:Colposcopy; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D014626:Vaginal Smears