title: [Determination of interleukin-6 messenger RNA as malignant progression index in monoclonal gammapathy of undetermined significance].
abstract: The monoclonal gammopathy of undetermined significance (MGUS) could be considered a preneoplastic condition since no clinical and laboratory features are able to identify in advance the patients at high risk of disease progression. In this study we analysed IL-6mRNA expression on both bone marrow mononuclear cells and peripheral blood mononuclear cells sample of multiple myeloma (MM) and MGUS patients for evaluation if IL-6mRNA expression could be considered diagnostic or prognostic aspect of progression disease risk to MM. We concluded that expression of IL-6mRNA hasn't prognostic significance for the progression disease risk to multiple myeloma but could have a discriminant significance the MM and MGUS pathologies when combined with gene rearrangements and immunochemicals analysis.
authors.affiliation: Centro Nazionale Trasfusione Sangue, Croce Rossa Italiana, Roma.
authors.forename: R
authors.initials: R
authors.lastname: Mancini
authors.forename: M
authors.initials: M
authors.lastname: Palange
authors.forename: M G
authors.initials: MG
authors.lastname: Dionisi
authors.forename: V
authors.initials: V
authors.lastname: De Angelis
authors.forename: A
authors.initials: A
authors.lastname: Matteocci
authors.forename: L
authors.initials: L
authors.lastname: Strano
mesh_terms: D015152:Blotting, Northern; D015870:Gene Expression; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D009101:Multiple Myeloma / Q000175:diagnosis / Q000235:genetics; D010265:Paraproteinemias / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D012307:Risk Factors
chemical_list: D015850:Interleukin-6; D012333:RNA, Messenger
vernacular_title: La misura di RNA messaggero dell'interleuchina-6 quale indice di progressione maligna della gammapatia monoclonale di significato incerto.