title: Acute respiratory distress syndrome: frequency, clinical course, and costs of care.
abstract: OBJECTIVE
  To define the occurrence rate of acute respiratory distress syndrome (ARDS) using established criteria in a well-defined general patient population, to study the clinical course of ARDS when patients were ventilated using a "lung-protective" strategy, and to define the total costs of care.
  
  
  METHODS
  A 3-yr (1993 through 1995) retrospective descriptive analysis of all patients with ARDS treated in Kuopio University Hospital.
  
  
  METHODS
  Intensive care unit in the university hospital.
  
  
  METHODS
  Fifty-nine patients fulfilled the definition of ARDS: Pao2/Fio2 <200 mm Hg (33.3 kPa) during mechanical ventilation and bilateral infiltrates on chest radiograph.
  
  
  METHODS
  None.
  
  
  RESULTS
  With a patient data management system, the day-by-day data of hemodynamics, ventilation, respiratory mechanics, gas exchange, and organ failures were collected during the period that Pao2/Fio2 ratio was <200 mm Hg (33.3 kPa). The frequency of ARDS was 4.9 cases/100,000 inhabitants/yr. Pneumonia and sepsis were the most common causes of ARDS. Mean age was 43+/-2 yrs. At the time of lowest Pao2/Fio2, the nonsurvivors had lower arterial and venous oxygen saturations and higher arterial lactate than survivors, whereas there were no differences between the groups in other parameters. Multiple organ dysfunction preceded the worst oxygenation in both the survivors and nonsurvivors. The intensive care mortality was 37%; hospital mortality and mortality after a minimum 8 months of follow-up was 42%. The most frequent cause of death was multiple organ failure. The effective costs of intensive care per survivor were US $73,000.
  
  
  CONCLUSIONS
  The outcome of ARDS is unpredictable at the time of onset and also at the time of the worst oxygenation. Keeping the inspiratory pressures low (30-35 cm H2O [2.94 to 3.43 kPa]) reduces the frequency of pneumothorax, and might lower the mortality. Most patients are young, and therefore the costs per saved year of life are low.
authors.affiliation: Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Valta
authors.forename: A
authors.initials: A
authors.lastname: Uusaro
authors.forename: S
authors.initials: S
authors.lastname: Nunes
authors.forename: E
authors.initials: E
authors.lastname: Ruokonen
authors.forename: J
authors.initials: J
authors.lastname: Takala
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D017048:Health Care Costs; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000191:economics / Q000379:methods; D012124:Respiratory Care Units / Q000191:economics* / Q000706:statistics & numerical data; D012128:Respiratory Distress Syndrome / Q000191:economics / Q000453:epidemiology / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate