title: Asymmetric Total Synthesis of Fluvirucinine A(1).
abstract: Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza-Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A(1) (1), the aglycon of fluvirucin A(1). Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1, Shinrim-Dong, Kwanak-Gu, Seoul 151-742 (Korea).
authors.initials: YG
authors.lastname: Suh
authors.initials: SA
authors.lastname: Kim
authors.initials: JK
authors.lastname: Jung
authors.initials: DY
authors.lastname: Shin
authors.initials: KH
authors.lastname: Min
authors.initials: BA
authors.lastname: Koo
authors.initials: HS
authors.lastname: Kim