Protein unfolding: mitochondria offer a helping hand.
Post-translocational protein import into mitochondria requires that the protein be unfolded prior to import. Mapping the mitochondrial-assisted unfolding pathway of a cargo protein and demonstrating that it deviates from the spontaneous unfolding pathway have provided valuable insight into the energetics of the translocation process.
Hebert
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D001426:Bacterial Proteins; D001692:Biological Transport; D008564:Membrane Potentials; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D008954:Models, Biological; D011489:Protein Denaturation; D017510:Protein Folding; D012260:Ribonucleases / Q000737:chemistry* / Q000378:metabolism*
D001426:Bacterial Proteins; D012260:Ribonucleases; C019760:Bacillus amyloliquefaciens ribonuclease