title: Postoperative downregulation of MHC class II antigen on monocytes does not differ between open and endovascular repair of aortic aneurysms.
abstract: OBJECTIVE
  To study immune cell response and histocompability class II (HLA-DR) expression after aortic aneurysm repair.
  
  
  METHODS
  University hospital, Sweden.
  
  
  METHODS
  42 patients operated on for aortic aneurysm, 26 by an endovascular and 16 by an open technique.
  
  
  METHODS
  Analysis of HLA-DR expression and concentrations of blood mononuclear cells by flow cytometry. Splanchnic pH analysed by tonometry and interleukin-6 and tumour necrosis factor-alpha measured by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The HLA-DR expression on lymphocytes did not change, whereas total HLA-DR expression on monocytes was downregulated, and more pronounced in five patients who developed severe postoperative complications. There were no differences in cell or HLA-DR responses between the two operations.
  
  
  CONCLUSIONS
  Both endovascular and open repair of aortic aneurysm produced similar downregulation of monocyte HLA-DR expression and similar responses in circulating mononuclear blood cells. There was pronounced downregulation of monocyte HLA-DR expression in patients with severe postoperative complications.
authors.affiliation: Department of Surgery, Malmö University Hospital, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Syk
authors.forename: A
authors.initials: A
authors.lastname: Andreasson
authors.forename: L
authors.initials: L
authors.lastname: Truedsson
authors.forename: B
authors.initials: B
authors.lastname: Risberg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D016207:Cytokines / Q000502:physiology; D015536:Down-Regulation; D005260:Female; D006684:HLA-DR Antigens / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D011184:Postoperative Period
chemical_list: D016207:Cytokines; D006684:HLA-DR Antigens