Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats.
We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-alpha production from RPMC.
Shin
T Y
TY
College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea.
Jeong
H J
HJ
Jun
S M
SM
Chae
H J
HJ
Kim
H R
HR
Baek
S H
SH
Kim
H M
HM
D000707:Anaphylaxis / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control; D000818:Animals; D004140:Dinitrophenols / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D019686:Lamiaceae / Q000737:chemistry; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors / Q000276:immunology
D004140:Dinitrophenols; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine