[The antioxidant protection of the heart by coenzyme Q10 in stable stenocardia of effort].
It was found that patients with angina of effort (functional class II and III) exhibit enhanced generation of active oxygen forms by leukocytes, higher concentration of malonic dialdehyde in plasma and lower antiperoxide resistance of plasma. These changes increase with increasing severity of the disease. Adjuvant use of coenzyme Q10 in combined antianginal therapy suppresses generation of active oxygen forms by leukocytes, lipid peroxidation. Antiperoxide plasma resistance rises. In this way clinical improvement of effort angina is achieved.
Kogan
A Kh
AKh
Syrkin
A L
AL
Drinitsina
S V
SV
Kokanova
I V
IV
D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D000975:Antioxidants / Q000627:therapeutic use*; D003067:Coenzymes; D004359:Drug Therapy, Combination; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D005082:Physical Exertion; D017382:Reactive Oxygen Species / Q000378:metabolism; D018709:Statistics, Nonparametric; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000975:Antioxidants; D003067:Coenzymes; D017382:Reactive Oxygen Species; D014451:Ubiquinone; C024989:coenzyme Q10
Antioksidantnaia zashchita serdtsa koénzimom Q10 pri stabil'noĭ stenokardii napriazheniia.