Autoantibodies against oxidized LDL in the first phase of life. Low density lipoproteins.
The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.
Steinerová
A
A
MEDICA Centrum Pilsen, Czech Republic.
Racek
J
J
Stozický
F
F
Tatzber
F
F
Lapin
A
A
D001323:Autoantibodies / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D005260:Female; D005609:Free Radicals; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood
D001323:Autoantibodies; D005609:Free Radicals; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008315:Malondialdehyde; D002784:Cholesterol; D013482:Superoxide Dismutase