title: Designed molecules that fold to mimic protein secondary structures.
abstract: Molecules that fold to mimic protein secondary structures have emerged as important targets of bioorganic chemistry. Recently, a variety of compounds that mimic helices, turns, and sheets have been developed, with notable advances in the design of beta-peptides that mimic each of these structures. These compounds hold promise as a step toward synthetic molecules with protein-like properties and as drugs that block protein-protein interactions.
authors.affiliation: Department of Chemistry, 535B Rowland Hall, University of California, Irvine, CA 92697-2025, USA. kstigers@uci.edu.
authors.forename: K D
authors.initials: KD
authors.lastname: Stigers
authors.forename: M J
authors.initials: MJ
authors.lastname: Soth
authors.forename: J S
authors.initials: JS
authors.lastname: Nowick
mesh_terms: D002240:Carbohydrate Sequence; D015195:Drug Design; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017433:Protein Structure, Secondary; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D011506:Proteins