Neural stem cells in the adult human brain.
New neurons are continuously generated in certain regions of the adult brain. Studies in rodents have shown that new neurons are generated from self-renewing multipotent neural stem cells. Here we demonstrate that both the lateral ventricle wall and the hippocampus of the adult human brain harbor self-renewing cells capable of generating neurons, astrocytes, and oligodendrocytes in vitro, i.e., bona fide neural stem cells.
Johansson
C B
CB
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, SE-171 77, Sweden.
Svensson
M
M
Wallstedt
L
L
Janson
A M
AM
Frisén
J
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002552:Cerebral Ventricles / Q000166:cytology*; D005260:Female; D006624:Hippocampus / Q000166:cytology*; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology