title: Assessment of the efficacy, safety and quality of gentamicin use in Aberdeen Royal Infirmary.
abstract: Fifty-five patients who received od gentamicin were studied. The protocol for od gentamicin was followed in 23/55 (48%). Cure rates were 22/23 (96%) when the protocol was followed and 24/32 (75%) when not followed (P = 0.06). Toxicity was more common in those in whom the protocol was not followed (9/32; 28%) than in those in whom it was followed (1/23; 4%) (P< 0.05). The number needed to treat with the protocol to produce one additional cure was 4.84 (95% CI 2.64 to 28.66) and the number needed to treat to prevent one case of toxicity was 3.61 (95% CI 2.16 to 10.99).
authors.affiliation: Department of Pharmacy, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB (b)The Infection Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB, UK.
authors.forename: K O
authors.initials: KO
authors.lastname: Buabeng
authors.forename: A R
authors.initials: AR
authors.lastname: Mackenzie
authors.forename: R B
authors.initials: RB
authors.lastname: Laing
authors.forename: I
authors.initials: I
authors.lastname: Cook
authors.forename: B
authors.initials: B
authors.lastname: Jappy
authors.forename: I M
authors.initials: IM
authors.lastname: Gould
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012606:Scotland; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins