Delta(12)-prostaglandin J(2) is a potent inhibitor of influenza A virus replication.
9-Deoxy-Delta(9),Delta(12)-13,14-dihydro-prostaglandin D(2) (Delta(12)-PGJ(2)), a natural cyclopentenone metabolite of prostaglandin D(2), is shown to possess therapeutic efficacy against influenza A virus A/PR8/34 (H1N1) infection in vitro and in vivo. The results indicate that the antiviral activity is associated with induction of cytoprotective heat shock proteins and suggest novel strategies for treatment of influenza virus infection.
Pica
F
F
Departments of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Palamara
A T
AT
Rossi
A
A
De Marco
A
A
Amici
C
C
Santoro
M G
MG
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D009980:Influenza A virus / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D018840:HSP70 Heat-Shock Proteins; D014764:Viral Proteins; D012313:RNA; C040810:9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2; D004247:DNA; D015230:Prostaglandin D2