Reconstruction of blood flow patterns in human arteries.
Local haemodynamic factors in large arteries are associated with the pathophysiology of cardiovascular diseases such as atherosclerosis and strokes. In search of these factors and their correlation with atheroma formation, quantitative haemodynamic data in realistic arterial geometry become crucial. At present no in vivo non-invasive technique is available that can provide accurate measurement of three-dimensional blood velocities and shear stresses in curved and branching sites of vessels where atherosclerotic plaques are found frequently. This paper presents a computer modelling technique which combines state-of-the-art computational fluid dynamics (CFD) with new noninvasive magnetic resonance imaging techniques to provide the complete haemodynamic data in 'real' arterial geometries. Using magnetic resonance angiographic and velocity images acquired from the aortic bifurcation of a healthy human subject, CFD simulations have been carried out and the predicted flow patterns demonstrate the non-planar-type flow characteristics found in experimental studies.
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Department of Chemical Engineering and Chemical Technology, Imperial College of Science, Technology and Medicine, London, UK.
Long
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Collins
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Bourne
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Griffith
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D001012:Aorta, Abdominal / Q000033:anatomy & histology / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D007083:Iliac Artery / Q000033:anatomy & histology / Q000502:physiology*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008955:Models, Cardiovascular; D012016:Reference Values; D013314:Stress, Mechanical; D013599:Systole / Q000502:physiology