title: Reproducibility of 99Tcm-MAG3 clearance in normal volunteers with the two-sample method: comparison with 131I-OIH.
abstract: The aim of this study was to evaluate the reproducibility of 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3) clearance and to compare it with that of 131I-orthoiodohippurate (131I-OIH), which is widely used in clinical practice. Twelve young healthy volunteers with a mean age of 23.4 years (range 19-28) were enrolled in the study. The investigations were repeated at an interval of 1 month under similar physiological conditions. Each volunteer received a simultaneous injection of 99Tcm-MAG3 and 131I-OIH that was commercially available in an already labelled form. Blood samples were obtained at 44 and 104 min post-injection. Clearance values were calculated using the two-sample method. The mean (+/- S.D.) change from the first to the second measurement was -7.1 +/- 11.1% for 99Tcm-MAG3 and 1.7 +/- 13.6% for 131I-OIH. There were no significant differences between the first and the second measurements of 99Tcm-MAG3 and 131I-OIH clearance, respectively. 99Tcm-MAG3 clearance was shown to be very similar to that of 131I-OIH in healthy volunteers.
authors.affiliation: Department of Radiology, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanazawa
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Seto
authors.forename: M
authors.initials: M
authors.lastname: Kageyama
authors.forename: K
authors.initials: K
authors.lastname: Kameda
authors.forename: S
authors.initials: S
authors.lastname: Toyoshima
authors.forename: G
authors.initials: G
authors.lastname: Tomizawa
authors.forename: N
authors.initials: N
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Inagaki
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D007465:Iodohippuric Acid / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012016:Reference Values; D015203:Reproducibility of Results; D017263:Technetium Tc 99m Mertiatide / Q000493:pharmacokinetics*
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D007465:Iodohippuric Acid; D017263:Technetium Tc 99m Mertiatide