title: Microbial interactions in the vaginal ecosystem, with emphasis on the pathogenesis of bacterial vaginosis.
abstract: During bacterial vaginosis (BV), populations of lactobacilli which are generally dominant in the vagina of overtly healthy women are replaced by other facultative and anaerobic microorganisms. Some Lactobacillus strains produce hydrogen peroxide and all produce lactic acid; however, the antagonistic role of these metabolites in vivo remains controversial. Positive interactions among BV-associated organisms may contribute to the pathogenesis of BV and its sequelae.
authors.affiliation: Channing Laboratory, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: V
authors.initials: V
authors.lastname: Pybus
authors.forename: A B
authors.initials: AB
authors.lastname: Onderdonk
mesh_terms: D000898:Antibiosis; D018407:Bacterial Physiological Phenomena; D017753:Ecosystem; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000378:metabolism; D007778:Lactobacillus / Q000502:physiology*; D014621:Vagina / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000382:microbiology*
chemical_list: D019344:Lactic Acid; D006861:Hydrogen Peroxide