Environmental covariates: effects on the power of sib-pair linkage methods.
The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.
Mandal
D M
DM
Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
Sorant
A J
AJ
Pugh
E W
EW
Marcus
S E
SE
Klein
A P
AP
Mathias
R A
RA
O'Neill
J
J
Temiyakarn
L F
LF
Wilson
A F
AF
Bailey-Wilson
J E
JE
D004777:Environment; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D016678:Genome; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D019655:Quantitative Trait, Heritable