Dendritic cells produce interleukin-12 in hyperthyroid mice.
We previously reported that serum interleukin-12 (IL-12) levels were significantly increased in patients with hyperthyroid Graves' disease and in normal subjects after administration of thyroid hormone. In the present study, we investigated which cells produce IL-12 and the interactions between IL-12 and thyroid hormones, using a hyperthyroid mouse model. Thyroid hormones induced IL-12 production, and IL-12 was mainly produced by dendritic cells outside the thyroid glands in a hyperthyroid state.
Tamura
M
M
The Third Department of Internal Medicine, School of Medicine, Ehime University, Ehime, Japan.
Matsuura
B
B
Miyauchi
S
S
Onji
M
M
D000818:Animals; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000378:metabolism*; D006980:Hyperthyroidism / Q000097:blood / Q000378:metabolism*; D016753:Interleukin-10 / Q000096:biosynthesis / Q000097:blood; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D013154:Spleen / Q000166:cytology
D016753:Interleukin-10; D018664:Interleukin-12