title: Natural history of elderly patients with asymptomatic meningiomas.
abstract: OBJECTIVE
  For the treatment of elderly patients with asymptomatic meningiomas, it is important to determine their natural history. Based on results of follow up examinations, the natural history of such patients was clarified and prognostic factors concerning the potential of tumour growth in the aged were identified.
  
  
  METHODS
  The clinical records and imaging studies of 40 elderly (over 70 years) patients with asymptomatic meningiomas were analysed. The patients were followed up with repeated imaging studies, and changes in tumour size, clinical signs, and outcomes were evaluated.
  
  
  RESULTS
  There were 32 women and eight men with a mean age of 76.1 years. The mean follow up period was 38.4 months, ranging from 6 to 97 months. Six patients died during the follow up period from disorders other than the tumours, and one patient died as a result of the tumour. Twenty six patients (mean follow up period 41.8 months, range 10-97 months) showed no tumour growth. Fourteen patients showed tumour growth (mean follow up period 32.1 months, range 6-88 months). Five (four men and one woman) of these patients became symptomatic. Based on imaging analysis (1) calcification of the tumour was associated with no tumour growth (p=0.036), and (2) the tumour size at the initial diagnosis was related to subsequent tumour growth (p=0.016). Other possible factors related to tumour growth included sex and hyperintensity on MRI T2 weighted images.
  
  
  CONCLUSIONS
  In elderly patients with asymptomatic meningiomas, careful clinical follow up with imaging studies is important. The imaging features mentioned may contribute to prediction of tumour growth.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, University of Kagoshima, Kagoshima, Japan 890-8520. niiromsk@med6.kufm.kagoshima-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Niiro
authors.forename: K
authors.initials: K
authors.lastname: Yatsushiro
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Kawahara
authors.forename: J
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D008579:Meningioma / Q000473:pathology* / Q000503:physiopathology*