Futalosine and its derivatives, new nucleoside analogs.
Futalosine, a new nucleoside analog, was isolated from a fermentation broth of Streptomyces sp. MK359-NF1. Some chemical derivatives of futalosine were prepared. 6-O-Methylfutalosine methylester inhibited growth of HeLa-S3 cells in vitro (IC50 = 19.5 micrograms/ml) in contrast to the weak activity of futalosine. 6-O-Methylfutalosine methylester at concentrations higher than 10 micrograms/ml inhibited incorporation of 3H-TdR and 3H-UR but not 3H-Leu in the acid-soluble fractions of HeLa-S3 cells.
Hosokawa
N
N
Institute of Microbial Chemistry, Shinagawa-ku, Tokyo, Japan.
Naganawa
H
H
Kasahara
T
T
Hattori
S
S
Hamada
M
M
Takeuchi
T
T
Yamamoto
S
S
Tsuchiya
K S
KS
Hori
M
M
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D009705:Nucleosides; C122040:futalosine