Loss of tissue immunoreactive androgen receptor in prostate cancer presenting initially as an intracranial tumor.
We report a case of prostate cancer that presented initially as an intracranial tumor. Biopsy specimens of the prostate before endocrine treatment were nearly negative immunohistochemically for prostate-specific antigen and the androgen receptors. All metastases including those in the brain expressed neither androgen receptor nor prostate-specific antigen at the protein and mRNA levels. The tumor, which did not respond to the anti-androgen therapy, had an aggressive course. In this case, the androgen-independent growth and rapid progression might be associated with the initial loss of the antigen and androgen characteristics of the prostate.
Ehara
H
H
Department of Urology and Pathology, Gifu University School of Medicine, Gifu City, Japan. deguchit@cc.gifu-u.ac.jp
Yang
M
M
Kawamura
T
T
Deguchi
T
T
Kawada
Y
Y
Shimokawa
K
K
Tanaka
T
T
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary*; D001932:Brain Neoplasms / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen; D017430:Prostate-Specific Antigen