Molecular mechanisms of liver development and differentiation.
Recent advances in identifying molecular signals that dictate liver development and differentiation have come from analysis of several experimental systems including the developing embryo, cell and tissue culture, knockout mice and transplantation of hepatic precursor cells. Fibroblast growth factors and several families of transcription factors including hepatocyte nuclear factors 1, 3 and 4 and CCAAT/enhancer-binding protein have been shown to be important components of the differentiation process that culminates in the fully functional liver.
Darlington
G J
GJ
Department of Pathology, Baylor College of Medicine, Huffington Center of Aging, Houston, TX 77030, USA. gretchen@bcm.tcm.edu.
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D022762:CCAAT-Enhancer-Binding Proteins; D002460:Cell Line; D004268:DNA-Binding Proteins / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D051542:Hepatocyte Nuclear Factor 3-beta; D051557:Hepatocyte Nuclear Factor 4; D008099:Liver / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D020033:Protein Isoforms; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; C496503:Foxa2 protein, mouse; D051557:Hepatocyte Nuclear Factor 4; D009687:Nuclear Proteins; D010750:Phosphoproteins; D020033:Protein Isoforms; C501970:Tcfl4 protein, mouse; D014157:Transcription Factors; D051542:Hepatocyte Nuclear Factor 3-beta; D005346:Fibroblast Growth Factors