title: Intraductal papilloma of the salivary gland. A report of two cases with diagnosis by fine needle aspiration biopsy.
abstract: BACKGROUND
  Intraductal papillomas are rare, benign tumors most commonly encountered in minor salivary glands. They are cystic, solitary neoplasms that arise from ductal epithelium and produce painless swellings.
  
  
  METHODS
  Two cases arose in major salivary glands. The first case was a superficial, firm mass at the superior edge of the parotid, cytologically evocative of an adnexal tumor. A firm, submandibular mass in the second case was diagnosed as a papillary neoplasm. Fluid was aspirated from both cases. Three-dimensional epithelial clusters, some with a papillary configuration and histiocytes, were the main cellular components. The majority of cells showed oncocytic differentiation; however, benign-appearing ductal cells in honeycomb sheets were also present. The first case also had occasional cells suggestive of sebaceous differentiation. The excised lesions were unilocular cystic papillary neoplasms consistent with intraductal papilloma; focal sebaceous differentiation was noted in the first case.
  
  
  CONCLUSIONS
  Awareness of the cytologic features of intraductal papilloma of the salivary glands should prompt its inclusion in the differential diagnosis of papillary lesions of the head and neck.
authors.affiliation: Department of Pathology, George Washington University Medical Center, Washington, D.C. 20037, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Soofer
authors.forename: S
authors.initials: S
authors.lastname: Tabbara
mesh_terms: D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018300:Papilloma, Intraductal / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*