title: [Neuronal death mechanisms in cerebral ischemia: laboratory at the clinic].
abstract: In this article we review the different stages in the development of a neuroprotector drug, such as cytocholine, starting with the initial experimental stage and ending with its effects when used clinically in humans. It has been confirmed experimentally that the drug has neuroprotector, neuro-repair and neurocognitive effects which are also observed when it is used to treat patients with acute ischaemic cerebrovascular accidents.
authors.affiliation: Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wurtman
mesh_terms: D000208:Acute Disease; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects* / Q000502:physiology*; D003566:Cytidine Diphosphate Choline / Q000096:biosynthesis; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents; D003566:Cytidine Diphosphate Choline
vernacular_title: La neurotoxicidad en la isquemia cerebral: del laboratorio a la clínica.