[Changes in the level of DNA minor bases in salivary gland inflammation and its correction with antioxidants].
In the experiment with guinea pigs at contact sialoadenitis reproduction (karragenine inflammation of soft tissues of the oral cavity) it was established that in DNA of salivary glands cells and the neighbouring tissues the content of 5-methylcytosine was decreased, it being normalized at "Triovit" antioxidant complex together with cvercitynum correction. The content of DNA 8-hydroxyguanine is characterized by a wide range of data and in absolute values increases in inflammation, but decreases after antioxidant correction. The role of the changes discovered is discussed.
Shevchenko
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Tsebrzhinskiĭ
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OI
D044503:5-Methylcytosine; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002351:Carrageenan; D003596:Cytosine / Q000031:analogs & derivatives / Q000032:analysis; D004247:DNA / Q000032:analysis / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D006147:Guanine / Q000031:analogs & derivatives / Q000032:analysis; D006168:Guinea Pigs; D012793:Sialadenitis / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*
D000975:Antioxidants; C024829:8-hydroxyguanine; D006147:Guanine; D044503:5-Methylcytosine; D003596:Cytosine; D002351:Carrageenan; D004247:DNA
Izmenenie soderzhaniia minornykh osnovaniĭ DNK pri vospalenii sliunnoĭ zhelezy i ego korrektsiia antioksidantami.