Salt water promotes hypertension in Dahl-S rats.
Hypertension was induced in Dahl-salt-sensitive (Dahl-S) rats by administering salt in drinking water. Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney. Rats receiving 0.5% NaCl solution developed moderate hypertension and renal lesions. Rats receiving 1.0% NaCl solution showed prominent and increasing hypertension and severe renal damage. This method of salt administration should be simpler than administration in the diet as a means of promoting renal hypertension. The lower concentration salt water caused chronic mild hypertension in Dahl-S rats, and may serve as a useful model for progressive hypertension.
Miura
N
N
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan.
Suzuki
S
S
Hamada
Y
Y
Kamimura
R
R
Fujiki
M
M
Misumi
K
K
Sakamoto
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D006321:Heart / Q000187:drug effects; D006977:Hypertension, Renal / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D020303:Rats, Inbred Dahl; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride