[Potential role of serotonin-sensitive structures in amplification of duodenal motor activity due to irritation of sympathetic trunk].
Acute experiments with dogs showed that irritation of the sympathetic trunk in the thoracic cavity is more likely to amplify than inhibit duodenal contractions. This stimulating effect is better seen with alpha- and beta-adrenoreceptors blocked by phentolamine hydrochloride and inderal and cannot be eliminated with dizergol used to block S1,2 receptors of the cellular membranes in smooth muscles. On the evidence and literary data it was deduced that the sympathetic trunk contains some serotoninergic nervous fibers potent to stimulate contractions of the duodenum.
Sveshnikov
D S
DS
Smirnov
V M
VM
Berseneva
E A
EA
D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000294:innervation*; D004873:Ergolines / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009130:Muscle, Smooth / Q000294:innervation / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D010812:Physical Stimulation; D011312:Pressure; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013268:Stimulation, Chemical
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004873:Ergolines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D011433:Propranolol; C061884:lysergol; D010646:Phentolamine
Vozmozhnaia rol' serotoninreaktivnykh struktur v usilenii dvigatel'noĭ aktivnosti dvenadtsatiperstnoĭ kishki, vysvannoĭ razdrazheniem simpaticheskogo stvola.