title: When does the patient with a disc herniation undergo lumbosacral discectomy?
abstract: OBJECTIVE
  To design a model that could accurately predict eventual lumbar disc surgery in the patient initially presenting with clinical findings of nerve root compression.
  
  
  METHODS
  Prospective study in 183 patients with nerve root compression sampled from a primary care population. All patients underwent a standardised history, physical examination, and MRI. Surgery carried out in the next 6 months was recorded. Models were constructed to predict whether patients eventually received surgery.
  
  
  RESULTS
  Two models were constructed. Reduced model A was based on baseline findings, only, and contained six variables. Model B incorporated change over time as well and contained 10 variables. The area under the curve (in a receiver operating characteristic) for these models was 0.86 and 0.92, respectively. It was shown that at a probability cut off of 0.60, model B predicted eventual surgery with a sensitivity of 57% and a specificity of 100%.
  
  
  CONCLUSIONS
  Given the requirement of a high specificity, eventual operation could be adequately predicted in a sample of 183 patients with clinical nerve root compression. The application of the model in patients with nerve root compression might lead to earlier operation in a subset of patients resulting in a reduction of duration of illness and associated indirect costs. An important prerequisite for future application would be the validation of the prediction rule in another population.
authors.affiliation: Department of Neurology, Maastricht University Hospital, Maastricht, The Netherlands.
authors.forename: P C
authors.initials: PC
authors.lastname: Vroomen
authors.forename: M C
authors.initials: MC
authors.lastname: de Krom
authors.forename: J A
authors.initials: JA
authors.lastname: Knottnerus
mesh_terms: D017586:Diskectomy / Q000379:methods*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013997:Time Factors