title: Signaling through Gp130: toward a general scenario of cytokine action.
abstract: Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines. We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.
authors.affiliation: Division of Molecular Oncology (C7), Osaka University Graduate School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukada
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Ohtani
authors.forename: T
authors.initials: T
authors.lastname: Shirogane
authors.forename: M
authors.initials: M
authors.lastname: Hibi
authors.forename: T
authors.initials: T
authors.lastname: Hirano
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D050822:Cytokine Receptor gp130; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130