Effect of Uncariae ramulus et Uncus on endothelium in spontaneously hypertensive rats.
The protective effect of the extract of Uncariae ramulus et Uncus (URE) against endothelium disorder due to hypertension was investigated. We administered low (150 mg/kg/day) and high (450 mg/kg/day) doses of URE orally to spontaneously hypertensive rats for 8 weeks. Endothelium dependent vasodilatation by acetylcholine increased significantly in the high URE group compared with the control group. Endothelium dependent vasocontraction by xanthine oxidase decreased significantly in the high URE group compared with the control group. Serum NO2-/NO3- were tended to increase in the high URE group. It is suggested that URE may have a protective effect for the endothelium against the influence of hypertension.
Goto
H
H
Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Japan.
Shimada
Y
Y
Tanigawa
K
K
Sekiya
N
N
Shintani
T
T
Terasawa
K
K
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects*; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D013997:Time Factors; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors; D014970:Xanthines / Q000494:pharmacology
D009566:Nitrates; D009573:Nitrites; D014970:Xanthines; D009569:Nitric Oxide; D014969:Xanthine Oxidase; D000109:Acetylcholine