title: Local haemodynamics of arterial bypass graft anastomoses.
abstract: One of the main causes of failure of expanded polytetrafluoroethylene (PTFE) bypass grafts used in the lower limbs is the development of myointimal hyperplasia (MIH). Clinical studies show that higher patency rates can be obtained with the use of an autologous vein cuff (the Miller cuff) interposed between the graft and artery. The reasons for the improved performance are still unclear, but preliminary studies suggest that the change in local haemodynamics due to the cuff geometry may be the significant factor rather than the presence of autologous material. If this is the case, then PTFE grafts can be produced with an integral cuff, i.e. a precuffed graft, with similar haemodynamic patterns to that of the Miller cuff. In this paper, two different types of precuffed graft are presented and their flow patterns are compared with those recorded in the Miller cuff and the conventional end-to-side anastomosis. The haemodynamic studies were carried out using optically clear silicone rubber models under simulated in vivo pulsatile flow conditions. Flow structures similar to those observed in the Miller cuff were seen in the precuffed grafts.
authors.affiliation: Department of Clinical Engineering, University of Liverpool, UK.
authors.forename: C S
authors.initials: CS
authors.lastname: Rowe
authors.forename: T K
authors.initials: TK
authors.lastname: Carpenter
authors.forename: T V
authors.initials: TV
authors.lastname: How
authors.forename: P L
authors.initials: PL
authors.lastname: Harris
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods / Q000706:statistics & numerical data; D001158:Arteries / Q000502:physiology* / Q000601:surgery*; D001783:Blood Flow Velocity / Q000502:physiology; D001807:Blood Vessel Prosthesis / Q000706:statistics & numerical data; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008955:Models, Cardiovascular; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design / Q000379:methods / Q000706:statistics & numerical data; D012826:Silicone Elastomers; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D012826:Silicone Elastomers; D011138:Polytetrafluoroethylene