title: [Cellular reactions induced by chronic exposure to 14C beta-rays].
abstract: In V-79 cells the Effects of chronic exposure on induction of chromosome aberrations and abnormal metaphases as well as on efficiency of subsequent exposure to 2 Gy gamma-rays were investigated. It was found that chronic exposure increased the yield of chromosome aberrations as well as abnormal metaphases (spread-metaphases and apoptotic metaphases). In spite of the level of damages in cells, the chronic beta-exposure protected cells against the additional induction of chromosomal aberrations by subsequent exposure to higher acute dose of gamma-irradiation. Cytogenetic adaptive response was retained in the surviving progeny of irradiated cells which were cultured in free medium during 40, 70 days or one year after chronic exposure. At this time the level of residual chromosome aberrations, colony forming ability and distribution of the cells by the number of chromosomes were almost the same as in unirradiated cells. However, the high level of abnormal metaphases and half as much of cells in colony in the surviving progeny of irradiated cells in comparison with unirradiated cell, allow us to suggest that the chronic exposure induced the selection of adaptive forms in condition of the higher level of radiation.
authors.affiliation: Petersburg Nuclear Physics Institute, Russian Academy of Science, Gatchina, St. Petersburg. giliano@omrb.pnpi.spb.ru
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Gil'iano
authors.forename: O I
authors.initials: OI
authors.lastname: Bol'shakova
authors.forename: E G
authors.initials: EG
authors.lastname: Bikineeva
authors.forename: L A
authors.initials: LA
authors.lastname: Noskin
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D001610:Beta Particles; D002250:Carbon Radioisotopes; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology / Q000528:radiation effects*; D008938:Mitosis / Q000528:radiation effects*
chemical_list: D002250:Carbon Radioisotopes
vernacular_title: Kletochnye otvety, indutsirovannye khronicheskim oblucheniem beta-chastitsami, ispuskaemymi pri raspade 14C.