title: Distribution of naive and memory T-cells in photoprovoked and spontaneous skin lesions of discoid lupus erythematosus and polymorphous light eruption.
abstract: Immune response to ultraviolet radiation-modified skin antigens has been suggested as a pathomechanism of skin lesions in discoid lupus erythematosus and polymorphous light eruption. In order to elucidate the role of T-lymphocyte subsets in this response, we studied the distribution of CD45RO+, CD45RA+ and CD31+ cells and the endothelial expression of adhesion molecules E-selectin/P-selectin, intercellular adhesion molecule-1 and CD31 antigen in photoprovoked and spontaneous skin lesions. Typically, CD45RA+ cells were the prevailing inflammatory cell population of discoid lupus erythematosus, whereas CD45RO+ cells prevailed in both diseases and in healthy controls. Epidermotrophism of any T-cell subsets was more typical of discoid lupus erythematosus, whereas no major differences in endothelial adhesion molecule expression was found between the 2 diseases. Strong keratinocyte ICAM-1 expression was associated with adjacent CD45RO+ cell infiltrates, not with CD45RA+ or CD31+ cell infiltrates. We conclude that the cellular immune response to UV radiation is dissimilar in discoid lupus erythematosus and polymorphous light eruption.
authors.affiliation: Department of Dermatology, University of Tampere and Tampere University Hospital, Finland. thasan@tays.fi
authors.forename: T
authors.initials: T
authors.lastname: Hasan
authors.forename: E
authors.initials: E
authors.lastname: Stephansson
authors.forename: A
authors.initials: A
authors.lastname: Ranki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001707:Biopsy, Needle; D017454:Dermatitis, Photoallergic / Q000276:immunology / Q000473:pathology*; D019040:E-Selectin / Q000032:analysis; D004817:Epidermis / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007156:Immunologic Memory; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis*; D008179:Lupus Erythematosus, Discoid / Q000276:immunology / Q000473:pathology*; D018655:Lymphocyte Count; D016177:Macrophage-1 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis*; D011379:Prognosis; D012680:Sensitivity and Specificity; D013601:T-Lymphocytes / Q000473:pathology*; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D015703:Antigens, CD; D019040:E-Selectin; D016177:Macrophage-1 Antigen; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D017493:Leukocyte Common Antigens