Esophagogastric anastomoses in rats--an experimental model.
Esophagectomy with esophagogastric anastomosis is not uncommonly complicated by anastomotic dehiscence. Although this is a major problem in clinical esophageal surgery, laboratory investigation of esophagogastric anastomotic wound healing has been hampered by the lack of a practical rodent model. Researchers have turned to large-animal experiments, or used various upper gastrointestinal pseudo-anastomotic techniques in rodents. None of these approaches has proved to be satisfactory. We report our technique of side-to-side esophagogastric anastomosis in the rat. Using this technique we have overcome the problems encountered in our earlier studies of esophagogastric anastomotic wound healing in the rat.
Cui
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Department of Thoracic Surgery, Roswell Park Cancer Institute, and State University of New York at Buffalo, USA.
Urschel
J D
JD
Petrelli
N J
NJ
D000714:Anastomosis, Surgical / Q000379:methods*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004943:Esophagogastric Junction / Q000601:surgery*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D013537:Sutures; D014945:Wound Healing