title: Impact of guidelines implemented in a paris university hospital: application to the use of antiemetics by cancer patients.
abstract: OBJECTIVE
  To assess the impact with time of guidelines on antiemetic use in an 850-bed Paris university hospital with a high proportion of cancer patients.
  
  
  METHODS
  Guidelines on the use of antiemetics available in cancer chemotherapy were drafted according to the Delphi technique. Their implementation was based upon a patient-specific antiemetic prescription form. To assess the impact of guideline implementation over time, discrepancies between current practice and the guidelines were compared before guideline implementation (between March and August 1995) and after implementation (between March and August 1997, and March and August 1998).
  
  
  RESULTS
  Before the Delphi panel's guidelines were implemented, 5-HT3 antagonists were inappropriately administered in 70% of cases. After guideline implementation, this proportion dropped significantly (P<0.0001, Fisher's exact test) to 22% between March and August 1997 and 28% between March and August 1998.
  
  
  CONCLUSIONS
  Implementation of guidelines seems to have resulted in significant changes with time, although a causal relationship has not been demonstrated. The development of guidelines by our hospital's multidisciplinary working group helped the various consultants to adjust medical practices to take account of these changes.
authors.affiliation: Service de Pharmacie-Toxicologie, Hôpital Tenon, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Debrix
authors.forename: A
authors.initials: A
authors.lastname: Flahault
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: L
authors.initials: L
authors.lastname: Schwartz
authors.forename: A
authors.initials: A
authors.lastname: Kanfer
authors.forename: B
authors.initials: B
authors.lastname: Milleron
mesh_terms: D000046:Academic Medical Centers / Q000592:standards*; D000932:Antiemetics / Q000008:administration & dosage*; D003697:Delphi Technique; D011307:Drug Prescriptions / Q000592:standards; D006801:Humans; D019300:Medical Errors / Q000517:prevention & control*; D009369:Neoplasms / Q000150:complications*; D010166:Palliative Care / Q000379:methods; D010297:Paris; D017410:Practice Guidelines as Topic; D012702:Serotonin Antagonists / Q000627:therapeutic use; D013997:Time Factors; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D012702:Serotonin Antagonists