title: Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease.
abstract: There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shimura-Miura
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: D
authors.initials: D
authors.lastname: Kang
authors.forename: K
authors.initials: K
authors.lastname: Miyako
authors.forename: Y
authors.initials: Y
authors.lastname: Nakabeppu
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D015415:Biomarkers; D045643:DNA Repair Enzymes; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008928:Mitochondria / Q000201:enzymology* / Q000473:pathology; D008956:Models, Chemical; D019578:Multiple System Atrophy / Q000201:enzymology; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D012016:Reference Values; D013378:Substantia Nigra / Q000201:enzymology* / Q000473:pathology
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D010744:Phosphoric Monoester Hydrolases; C078207:8-oxodGTPase; D045643:DNA Repair Enzymes; D003849:Deoxyguanosine