title: [Procainamide-induced skin eruption associated with disseminated intravascular coagulation in a patient with sustained ventricular tachycardia].
abstract: A 70-year-old man, who had sustained ventricular tachycardias following a previous anterior myocardial infarction, suffered from skin eruptions and abnormal blood tests after 10 days following the oral administration of 1500 mg/day of procainamide. These abnormalities disappeared early after the discontinuation of oral procainamide. However, similar skin eruptions exhibited again when the procainamide was resumed. These results suggest that oral procainamide therapy induces skin eruptions and serious abnormal blood tests in the patient. No reports have suggested such a serious early complication by procainamide therapy. Careful follow-up is needed after the administration of oral procainamide therapy.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, University Hospital, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Numata
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Nakashima
authors.forename: O
authors.initials: O
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Kohshi
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008297:Male; D011342:Procainamide / Q000009:adverse effects* / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000889:Anti-Arrhythmia Agents; D011342:Procainamide