title: Detection of endometrial adenocarcinoma in two asymptomatic postmenopausal women receiving tamoxifen. A report of two cases.
abstract: BACKGROUND
  Tamoxifen has been linked to an increased risk for the development of endometrial adenocarcinoma. The majority of these carcinomas present with postmenopausal bleeding. The current standard is to undertake sampling only after the onset of bleeding.
  
  
  METHODS
  Two cases illustrate the utility of transvaginal saline infusion sonohysterography (TVS/SIS) in the detection of endometrial carcinoma prior to the onset of bleeding.
  
  
  CONCLUSIONS
  Annual TVS/SIS may be useful for screening asymptomatic, tamoxifen-exposed patients with a uterus in situ and is likely to be more acceptable to such patients than annual biopsies.
authors.affiliation: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis 46202, USA. klook@iupui.edu
authors.forename: K
authors.initials: K
authors.lastname: Look
authors.forename: B
authors.initials: B
authors.lastname: Sanders
authors.forename: M
authors.initials: M
authors.lastname: Eastlund
authors.forename: G
authors.initials: G
authors.lastname: Sutton
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001706:Biopsy; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D017698:Postmenopause; D012965:Sodium Chloride; D013629:Tamoxifen / Q000009:adverse effects*; D014463:Ultrasonography / Q000379:methods*; D014621:Vagina / Q000000981:diagnostic imaging
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D012965:Sodium Chloride