title: In vitro activities of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pediococcus isolates.
abstract: Testing of susceptibility to 13 antibiotics was performed with 90 isolates of Lactobacillus, Leuconostoc, and Pediococcus. MICs at which 90% of the isolates tested were inhibited by HMR3647, erythromycin, and ciprofloxacin were 0.015, 0.125 and 32 microg/ml, respectively. The penicillin MIC was > or = 16 microg/ml against 26.2% of the studied Lactobacillus sp. isolates and 50% of Lactobacillus plantarum. HMR3647 showed excellent activity against these genera.
authors.affiliation: Area Bioquímica y Biología Molecular, Universidad de la Rioja, 26004 Logroño, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Zarazaga
authors.forename: Y
authors.initials: Y
authors.lastname: Sáenz
authors.forename: A
authors.initials: A
authors.lastname: Portillo
authors.forename: C
authors.initials: C
authors.lastname: Tenorio
authors.forename: F
authors.initials: F
authors.lastname: Ruiz-Larrea
authors.forename: R
authors.initials: R
authors.lastname: Del Campo
authors.forename: F
authors.initials: F
authors.lastname: Baquero
authors.forename: C
authors.initials: C
authors.lastname: Torres
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D048628:Ketolides; D007778:Lactobacillus / Q000187:drug effects* / Q000235:genetics; D007934:Leuconostoc / Q000187:drug effects* / Q000235:genetics; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010376:Pediococcus / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D048628:Ketolides; D018942:Macrolides; D002939:Ciprofloxacin; D004917:Erythromycin; C106791:telithromycin