Minocycline-induced clinical and biological lupus-like disease.
A 14-year-old girl developed maculopapular rash, myalgias, arthralgias and myocarditis with elevated anti-nuclear and anti-double-stranded DNA antibodies. She was taking minocycline for acne and all symptoms resolved when this treatment was stopped. The patient has no evidence of disease one year after onset of symptoms. Clinicians should be aware of minocycline's responsibility in inducing lupus-like disease.
Tournigand
C
C
Service de Médecine Interne de la Salpêtrière, Centre Hospitalier de Sens, France.
Généreau
T
T
Prudent
M
M
Diemert
M C
MC
Herson
S
S
Chosidow
O
O
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000276:immunology; D005260:Female; D006801:Humans; D008177:Lupus Vulgaris / Q000139:chemically induced* / Q000276:immunology / Q000503:physiopathology; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000974:Antibodies, Antinuclear; D008911:Minocycline