title: Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro.
abstract: The influence of individual conjugated linoleic acid (CLA) isomers on the delta6 desaturation of linoleic and alpha-linolenic acids and on the delta9 desaturation of stearic acid was investigated in vitro, using rat liver microsomes. The delta6 desaturation of 18:2n-6 was decreased from 23 to 38% when the ratio of 9cis,11trans-18:2 to 18:2n-6 increased from 0.5 to 2. The compound 10trans,12cis-18:2 exhibited a similar effect only at the highest concentration. The delta6 desaturation of alpha-linolenic acid was slightly affected by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the delta9 desaturation of stearic acid was 10trans,12cis-18:2.
authors.affiliation: INRA, Unité de Nutrition Lipidique, Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Bretillon
authors.forename: J M
authors.initials: JM
authors.lastname: Chardigny
authors.forename: S
authors.initials: S
authors.lastname: Grégoire
authors.forename: O
authors.initials: O
authors.lastname: Berdeaux
authors.forename: J L
authors.initials: JL
authors.lastname: Sébédio
mesh_terms: D000818:Animals; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D019787:Linoleic Acid / Q000378:metabolism / Q000494:pharmacology*; D050602:Linoleoyl-CoA Desaturase; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D013229:Stearic Acids / Q000378:metabolism; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism; D017962:alpha-Linolenic Acid / Q000378:metabolism
chemical_list: D013229:Stearic Acids; D017962:alpha-Linolenic Acid; C031183:stearic acid; D019787:Linoleic Acid; D044943:Fatty Acid Desaturases; D013230:Stearoyl-CoA Desaturase; D050602:Linoleoyl-CoA Desaturase