title: Sensitization to Aspergillus species in the congenital neutrophil disorders chronic granulomatous disease and hyper-IgE syndrome.
abstract: BACKGROUND
  Hyper-IgE syndrome (HIE) and chronic granulomatous disease (CGD) are congenital immunodeficiency diseases with increased susceptibility to bacterial and fungal infections. Both carry significant morbidity and mortality rates because of invasive infections by Aspergillus species. We encountered 2 patients, one with HIE and one with CGD, in whom detection of sensitization to Aspergillus species preceded the diagnosis of immunodeficiency. With high-dose systemic corticosteroids for allergic bronchopulmonary aspergillosis (ABPA), an inflammatory disorder caused by sensitization to Aspergillus species, pulmonary abscesses developed in the patient with HIE, and the patient with CGD succumbed to an overwhelming Aspergillus species-induced pneumonia.
  
  
  OBJECTIVE
  We sought to assess the prevalence of sensitization to Aspergillus fumigatus and the presence of diagnostic criteria for ABPA in patients with CGD and HIE.
  
  
  METHODS
  We measured A fumigatus-specific serum IgE, IgG, and precipitating antibodies as indicators for A fumigatus sensitization in the sera of 18 patients with neutrophil disorders (7 with HIE and 11 with CGD). Hospital records were reviewed for the presence of other diagnostic criteria for ABPA (asthma, elevated total serum IgE concentration, and radiographic abnormalities).
  
  
  RESULTS
  Twelve (67%) of 18 patients were sensitized to A fumigatus, as evidenced by precipitating A fumigatus-specific antibodies. Six (33%) of 18 patients had serologic evidence of ABPA. Five of those 6 patients had radiologic abnormalities consistent with a diagnosis of ABPA. One patient with HIE also had asthma, thus fulfilling minimal essential criteria for concurrent ABPA.
  
  
  CONCLUSIONS
  Patients with HIE syndrome and CGD have a high incidence of sensitization to Aspergillus species. A clinical picture indistinguishable from ABPA may coexist or emerge in patients with CGD or HIE and create a major management dilemma because systemic corticosteroids may accelerate tissue damage and invasive fungal infections. It is important to distinguish individuals with congenital neutrophil disorders from uncomplicated classic ABPA.
authors.affiliation: Department of Pediatrics, Division of Allergy/Immunology/Rheumatology UCLA Medical School, Los Angeles, CA, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Eppinger
authors.forename: P A
authors.initials: PA
authors.lastname: Greenberger
authors.forename: D A
authors.initials: DA
authors.lastname: White
authors.forename: A E
authors.initials: AE
authors.lastname: Brown
authors.forename: C
authors.initials: C
authors.lastname: Cunningham-Rundles
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D001228:Aspergillosis / Q000276:immunology; D001232:Aspergillus fumigatus / Q000276:immunology; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy* / Q000382:microbiology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization; D007589:Job Syndrome / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination