title: Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children.
abstract: Acute otitis media (AOM) is a common infectious disease in children. Some children experience recurrent episodes of AOM. Recent investigations demonstrate antigen-specific immunological deficiencies in children prone to AOM. In the present study, the immune responses to non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae) were further investigated in otitis-prone children and normal children. Forty-eight percent of otitis-prone children exhibited reduced IgG2 levels to S. pneumoniae and 55% exhibited reduced IgG levels to NTHi. These data suggest that otitis proneness appears to be related to numerous immunological derangements. Pathogen-specific antibodies are a reliable measure of otitis proneness.
authors.affiliation: Department of Otorhinolaryngology, Wakayama Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hotomi
authors.forename: N
authors.initials: N
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: J
authors.initials: J
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Suzumoto
authors.forename: M
authors.initials: M
authors.lastname: Suetake
authors.forename: H
authors.initials: H
authors.lastname: Faden
mesh_terms: D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000097:blood*; D016667:Bacterial Capsules / Q000276:immunology*; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology* / Q000302:isolation & purification; D016009:Chi-Square Distribution; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology / Q000382:microbiology; D005260:Female; D018073:Haemophilus Vaccines / Q000276:immunology* / Q000302:isolation & purification; D006193:Haemophilus influenzae / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008970:Molecular Weight; D010033:Otitis Media / Q000276:immunology* / Q000382:microbiology; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D018073:Haemophilus Vaccines; D007074:Immunoglobulin G; C069990:P6 outer membrane protein, Haemophilus; D011135:Polysaccharides, Bacterial