Coexistence of thin membrane and alport nephropathies in families with haematuria.
The finding of familial haematuria without a history of deafness or renal impairment is often assumed to indicate a benign prognosis. However, we describe three families in whom Alport and thin basement membrane nephropathy were separately identified within the same pedigree. Our findings illustrate the importance of fully investigating families with haematuria, even if thin basement nephropathy has been diagnosed in one member.
Moghal
N E
NE
Department of Nephrology, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
Milford
D V
DV
White
R H
RH
Raafat
F
F
Higgins
R
R
D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D002648:Child; D002675:Child, Preschool; D005260:Female; D006417:Hematuria / Q000150:complications* / Q000235:genetics; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009394:Nephritis, Hereditary / Q000150:complications* / Q000235:genetics / Q000473:pathology; D010375:Pedigree