title: Non-MHC gene regulation of nerve root injury induced spinal cord inflammation and neuron death.
abstract: Spinal ventral root avulsion leads to an inflammatory response around lesioned motoneurons and the subsequent degeneration of a large proportion of the neurons. We demonstrate here differences in the regulation of cytokine mRNAs, microglia/macrophage activation, MHC expression and nerve cell survival in the two inbred rat strains DA and ACI. These strains have similar major MHC haplotypes, but differ in their non-MHC background genes. T cells were rare in the lesioned segments and depletion of T cells did not affect the response. Thus, non-MHC gene(s) regulate the inflammation and neuron death after nerve trauma by mechanisms not involving antigen-specific immune responses.
authors.affiliation: Department of Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden. fredrik.piehl@cmm.ki.se
authors.forename: F
authors.initials: F
authors.lastname: Piehl
authors.forename: C
authors.initials: C
authors.lastname: Lundberg
authors.forename: M
authors.initials: M
authors.lastname: Khademi
authors.forename: A
authors.initials: A
authors.lastname: Bucht
authors.forename: I
authors.initials: I
authors.lastname: Dahlman
authors.forename: J C
authors.initials: JC
authors.lastname: Lorentzen
authors.forename: T
authors.initials: T
authors.lastname: Olsson
mesh_terms: D000818:Animals; D016923:Cell Death; D003433:Crosses, Genetic; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007371:Interferon-gamma / Q000502:physiology; D008285:Major Histocompatibility Complex; D009046:Motor Neurons / Q000473:pathology*; D009187:Myelitis / Q000209:etiology*; D009457:Neuroglia / Q000502:physiology; D051381:Rats; D011912:Rats, Inbred ACI; D013045:Species Specificity; D013126:Spinal Nerve Roots / Q000293:injuries*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D000949:Histocompatibility Antigens Class II; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma