title: Tissue reactivity to poliglecaprone 25 in the feline linea alba.
abstract: OBJECTIVE
  To use poliglecaprone 25 for all ligations and closure in routine feline ovariohysterectomies and evaluate maintenance of tissue approximation and tissue reaction to the suture.
  
  
  METHODS
  Prospective, descriptive study.
  
  
  METHODS
  Twenty four female cats.
  
  
  METHODS
  Ovariohysterectomies were performed in all cats. Abdominal incisions were inspected on days 1, 3, 7, 14, and 28 for dehiscence and swelling. All cats were euthanatized postoperatively, group 1 on day 7; group 2 on day 14; and group 3 on day 28. The peritoneal cavity was inspected for adhesions and all abdominal incisions were collected en bloc. Each linea alba was histologically evaluated and the inflammatory reaction was characterized.
  
  
  RESULTS
  Dehiscence did not occur in any of the 24 cats. The incisional swelling on day 1 was significantly smaller than on day 7, and the swelling on day 14 was significantly smaller than on days 1, 3, and 7 (P < .05). Intra-abdominal adhesions were found in all groups with the greatest number associated with the peritoneum at the incision site. Tissue reactions in group 1 were pyogranulomatous or fibromononuclear, group 2 were granulomatous or fibromononuclear, and group 3 were pyogranulomatous, granulomatous, fibromononuclear or fibrous. Eosinophilic infiltration was seen in 3 of the 8 cats in group 1.
  
  
  CONCLUSIONS
  Incisional swelling and inflammatory reactions seen with poliglecaprone 25 were consistent with those anticipated after implantation of suture in a surgically created wound.
  
  
  CONCLUSIONS
  Poliglecaprone 25 appears to be an acceptable suture for use in feline ovariohysterectomy. It causes a relatively short-lived inflammatory response.
authors.affiliation: Department of Small Animal Medicine, College of Veterinary Medicine, The University of Georgia, Athens, USA.
authors.forename: A
authors.initials: A
authors.lastname: Runk
authors.forename: S W
authors.initials: SW
authors.lastname: Allen
authors.forename: E A
authors.initials: EA
authors.lastname: Mahaffey
mesh_terms: D000005:Abdomen; D000818:Animals; D002415:Cats / Q000601:surgery*; D004146:Dioxanes / Q000009:adverse effects*; D005260:Female; D007044:Hysterectomy / Q000379:methods / Q000662:veterinary; D007249:Inflammation / Q000139:chemically induced / Q000662:veterinary; D009852:Omentum; D010052:Ovariectomy / Q000662:veterinary; D010532:Peritoneal Diseases / Q000662:veterinary; D011091:Polyesters / Q000009:adverse effects*; D011184:Postoperative Period; D011446:Prospective Studies; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013529:Surgical Wound Dehiscence / Q000662:veterinary; D013536:Suture Techniques / Q000662:veterinary; D013537:Sutures / Q000662:veterinary*; D000267:Tissue Adhesions / Q000662:veterinary
chemical_list: D004146:Dioxanes; D011091:Polyesters; C095495:glycolide E-caprolactone copolymer