Utility of the monoclonal antibody HIK1083 in the diagnosis of adenoma malignum of the uterine cervix.
OBJECTIVE
The aim of this study was to qualify a staining technique for the diagnosis of adenoma malignum.


METHODS
The gastric mucin expression of adenoma malignum, ordinary endocervical adenocarcinoma, and normal cervical glands was immunohistochemically compared using the monoclonal antibody HIK1083.


RESULTS
The three categories were clearly distinguished, with 90% (9/10) of cases with positive adenoma malignum, 30% (3/10) of cases with weakly positive ordinary cervical adenocarcinoma, and no (0/10) cases of positive normal cervical glands.


CONCLUSIONS
This preliminary report indicates that the use of HIK1083 is valuable in the diagnosis of adenoma malignum.
Utsugi
K
K
Cancer Institute Hospital, Department of Pathology, Cancer Institute, 1-37-1, Kami-Ikebukuro, Toshima-ku, Tokyo, 170-8455, Japan.
Hirai
Y
Y
Takeshima
N
N
Akiyama
F
F
Sakurai
S
S
Hasumi
K
K
D000236:Adenoma / Q000175:diagnosis*; D000911:Antibodies, Monoclonal / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009077:Mucins / Q000032:analysis* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D009077:Mucins