Early events in ultraviolet light-induced skin lesions in lupus erythematosus: expression patterns of adhesion molecules ICAM-1, VCAM-1 and E-selectin.
In our previous study, photoprovocation induced lupus erythematosus (LE) and polymorphous light eruption-like lesions in photosensitive LE patients. In this new study we examined the expression of ICAM-1, VCAM-1 and E-selectin, in early lesions in particular. A total of 32 patients with cutaneous LE, 25 with "classic" discoid LE, and 7 with systemic LE, including 3 patients with subacute cutaneous LE, were provoked with UVA and UVB on normal appearing skin. Induced lesions were followed up with serial biopsies. LE-like histopathology was seen within 1 week of provocation in some cases. Adhesion molecule expression was statistically significantly affected by the factors clinical diagnosis and wavelength (UVA or UVB). Strong keratinocyte ICAM-1 expression was found 1 week after provocation in reactions that eventually developed into long-standing ones. It is possible that these early changes reflect an underlying defect in the mechanisms that regulate adhesion molecule expression in LE.
Nyberg
F
F
Department of Dermatology, Karolinska Hospital and Institute, Stockholm, Sweden. inverness@beta.telenordia.se
Hasan
T
T
Skoglund
C
C
Stephansson
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D019040:E-Selectin / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications / Q000473:pathology*; D008179:Lupus Erythematosus, Discoid / Q000150:complications / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000175:diagnosis; D011379:Prognosis; D011829:Radiation Dosage; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology* / Q000528:radiation effects*; D014466:Ultraviolet Rays; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis*
D015415:Biomarkers; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1