Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13.
To investigate the cellular origin and the mechanisms of multinucleated giant cell (MGC) formation in the CNS, various cytokines were applied to isolated murine microglia. All the single cytokines failed to induce MGC. However, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the presence of colony stimulating factors, which was inhibited by either anti-IL-13 or anti-fms antibody. T helper 2 (Th2)-derived cytokines can induce MGC formation even in the absence of infectious agents.
Suzumura
A
A
Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan. asuzumur@naramed-u.ac.jp
Tamaru
T
T
Yoshikawa
M
M
Takayanagi
T
T
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000276:immunology; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D015726:Giant Cells / Q000166:cytology* / Q000187:drug effects; D018793:Interleukin-13 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000166:cytology* / Q000187:drug effects; D018418:Th2 Cells / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D003115:Colony-Stimulating Factors; D018793:Interleukin-13; D016212:Transforming Growth Factor beta; D015847:Interleukin-4