title: Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations.
abstract: Coeliac disease (CD) is a multifactorial disease for which there is an intensive search for genetic risk factors. Some authors found an association between the CTLA-4 region and CD. In the present work, we investigate the possible implication of the CTLA-4 region as a genetic risk factor for CD, through two statistical approaches: the maximum likelihood score (MLS) test in a large Italian sample of affected sib-pairs using polymorphic genetic markers on chromosome 2, and the transmission disequilibrium test (TDT) in continental Italian and Tunisian families using the CTLA-4 exon 1 49 A/G polymorphism. None of these approaches provides evidence for linkage or association between the CTLA-4 region and CD. This might result from a difference in the CTLA-4 region from population to population, either in its involvement as a risk factor or in the strength of linkage disequilibrium.
authors.affiliation: Laboratoire de Cytogénétique et Génétique Moléculaire Humaine, Université de Versailles, France. Fabienne.Clot@cytogene.uvsq.fr
authors.forename: F
authors.initials: F
authors.lastname: Clot
authors.forename: M C
authors.initials: MC
authors.lastname: Fulchignoni-Lataud
authors.forename: C
authors.initials: C
authors.lastname: Renoux
authors.forename: S
authors.initials: S
authors.lastname: Percopo
authors.forename: F
authors.initials: F
authors.lastname: Bouguerra
authors.forename: M C
authors.initials: MC
authors.lastname: Babron
authors.forename: I
authors.initials: I
authors.lastname: Djilali-Saiah
authors.forename: S
authors.initials: S
authors.lastname: Caillat-Zucman
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: L
authors.initials: L
authors.lastname: Greco
authors.forename: J L
authors.initials: JL
authors.lastname: Serre
mesh_terms: D000069594:Abatacept; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D018796:Immunoconjugates; D007558:Italy; D008297:Male; D011110:Polymorphism, Genetic; D014416:Tunisia
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D005819:Genetic Markers; D018796:Immunoconjugates; D000069594:Abatacept