Granulocyte colony-stimulating factor: its potential role in infectious disease.
Studies on the role of endogenous granulocyte colony-stimulating factor (G-CSF) in host defense indicate that, in addition to its anti-infectious role, this cytokine has an immunomodulatory function and also augments antibiotic efficacy. Pre-clinical and clinical trials with Filgrastim, recombinant-methionyl human G-CSF, in neutropenic and non-neutropenic infections demonstrate a reduction in morbidity and mortality. This is attributed to Filgrastim's ability to control infectious complications and permit continuation of immunosuppressive therapies.
Hartung
T
T
University of Konstanz, Biochemical Pharmacology, Germany. Thomas.Hartung@UNI-Konstanz.DE
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003141:Communicable Diseases / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D009504:Neutrophils / Q000276:immunology / Q000378:metabolism; D011994:Recombinant Proteins
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim