Hippocampal auditory gating in the hyperactive mocha mouse.
The mouse mutants mocha (mh) and mocha2J (mh2J) result from separate mutations in the same gene (AP-3 delta) that arose independently on different backgrounds of inbred strains. They exhibit a neurological phenotype that includes hyperactivity, an epileptiform EEG and changes in the basic function of the hippocampus. Depth electrode recordings of hippocampal auditory evoked potentials revealed that the response to the first of two paired tones was significantly enhanced in mocha and mocha2J, as compared with littermate controls. The pronounced theta rhythm characteristic of unanesthetized mocha mice was not observed in these chloral-hydrate anesthetized mice, whereas spike discharge activity was frequently present in the recordings.
Miller
C L
CL
Mental Health Research Institute, University of Michigan, Ann Arbor 48109, USA. clmiller@welchlink.welch.jhu.edu
Burmeister
M
M
Stevens
K E
KE
D000161:Acoustic Stimulation / Q000379:methods; D033963:Adaptor Protein Complex 3; D033966:Adaptor Protein Complex beta Subunits; D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology; D005072:Evoked Potentials, Auditory; D006624:Hippocampus / Q000503:physiopathology*; D006948:Hyperkinesis / Q000235:genetics* / Q000503:physiopathology*; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics / Q000502:physiology*; D010641:Phenotype; D013826:Theta Rhythm; D014157:Transcription Factors / Q000235:genetics
D033963:Adaptor Protein Complex 3; D033966:Adaptor Protein Complex beta Subunits; C113910:Ap3d1 protein, mouse; D014157:Transcription Factors