Further hypotensive metabolites from Verbesina caracasana.
After the isolation of caracasanamide and caracasandiamide, further hypotensive components of Verbesina caracasana were shown to be N3-prenylagmatine, N1-3',4'-dimethoxycinnamoylagmatine, agmatine and galegin (prenylguanidine). The structures were assigned on the basis of the spectral data of both metabolites and products from their alkaline hydrolyses. A pharmacological analysis of these products is also presented.
Delle Monache
G
G
Centro Chimica dei Recettori, Università Cattolica, Rome, Italy. g.dellemonache@uniserv.ccr.rm.cnr.it
Volpe
A R
AR
Delle Monache
F
F
Vitali
A
A
Botta
B
B
Espinal
R
R
De Bonnevaux
S C
SC
De Luca
C
C
Botta
M
M
Corelli
F
F
Carmignani
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000302:isolation & purification*; D019659:Asteraceae / Q000737:chemistry*; D013058:Mass Spectrometry; D051381:Rats
D000959:Antihypertensive Agents