The relationship between glycated hemoglobin and polymorphonuclear leukocyte leukotriene B4 release in people with diabetes mellitus.
In order to evaluate polymorphonuclear leukocyte (PMN) activity in diabetes mellitus, leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1 diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+/-0.2 pg/100 microl) in diabetic patients were higher compared to those of the control group (7.9+/-0.1 pg/100 microl) (P < 0.001), and remained significantly higher (P < 0.001) (12.8+/-0.2 pg/100 microl) than in the control group (11.0+/-0.2 pg/100 microl) after stimulation with calcium ionophore. A significant and positive correlation between glycated hemoglobin and LTB4 was demonstrated (P < 0.001, r = 0.80). This study demonstrates that in diabetic patients there is a PMN activation and that this activation is correlated to glycated hemoglobin level.
Parlapiano
C
C
II Clinica Medica, Cattedra di Endocrinologia, Policlinico Umberto I, University of Rome La Sapienza, Italy.
Danese
C
C
Marangi
M
M
Campana
E
E
Pantone
P
P
Giovanniello
T
T
Zavattaro
E
E
Sanguigni
S
S
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis
D001786:Blood Glucose; D000001:Calcimycin; D006442:Glycated Hemoglobin; D007975:Leukotriene B4