Signaling through Gp130: toward a general scenario of cytokine action.
Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines. We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.
Fukada
T
T
Division of Molecular Oncology (C7), Osaka University Graduate School of Medicine, Japan.
Yoshida
Y
Y
Nishida
K
K
Ohtani
T
T
Shirogane
T
T
Hibi
M
M
Hirano
T
T
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D050822:Cytokine Receptor gp130; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130