Primidone-loaded poly-epsilon-caprolactone nanocapsules: incorporation efficiency and in vitro release profiles.
This paper describes the preparation of primidone-loaded poly-epsilon-caprolactone nanocapsules according to the interfacial deposition technique. The colloidal suspension obtained showed a monomodal size distribution with a mean diameter ranging from 308 to 352 nm. By adjusting the process parameters, the encapsulation efficiency was about 74% with good reproducibility. Primidone release from the nanocapsules was found to be slower as compared to the oily control solution despite an important burst-effect. The release profile was not influenced by the pH of the release medium.
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Laboratoire de Pharmacochimie, U.F.R de Médecine-Pharmacie, 22 Boulevard Gambetta, 76183, Rouen Cedex, France.
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D002208:Caproates / Q000737:chemistry*; D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007783:Lactones / Q000737:chemistry*; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011324:Primidone / Q000737:chemistry / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012995:Solubility; D013997:Time Factors
D002208:Caproates; D002214:Capsules; D007783:Lactones; D009821:Oils; D011108:Polymers; D011324:Primidone; C121056:caprolactone