title: Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring. Part 1: Guanosine analogues.
abstract: Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8-azaguanine (compounds 4, 6, and 7) base on the amino group of (1'S,3'R)-3-(3'-amino-2',2'-dimethylcyclobutyl)propan-1-ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.
authors.affiliation: Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Figueira
authors.forename: J M
authors.initials: JM
authors.lastname: Blanco
authors.forename: O
authors.initials: O
authors.lastname: Caamaño
authors.forename: F
authors.initials: F
authors.lastname: Fernández
authors.forename: X
authors.initials: X
authors.lastname: García-Mera
authors.forename: C
authors.initials: C
authors.lastname: López
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003503:Cyclobutanes / Q000138:chemical synthesis / Q000494:pharmacology; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014780:Viruses / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003503:Cyclobutanes; D009705:Nucleosides