Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.
Renau
T E
TE
Microcide Pharmaceuticals Inc., 850 Maude Avenue, Mountain View, California 94043, USA. tomrenau@microcide.com
Léger
R
R
Flamme
E M
EM
Sangalang
J
J
She
M W
MW
Yen
R
R
Gannon
C L
CL
Griffith
D
D
Chamberland
S
S
Lomovskaya
O
O
Hecker
S J
SJ
Lee
V J
VJ
Ohta
T
T
Nakayama
K
K
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D004357:Drug Synergism; D010450:Endopeptidases / Q000378:metabolism; D015870:Gene Expression; D064704:Levofloxacin; D026901:Membrane Transport Proteins; D015394:Molecular Structure; D015242:Ofloxacin / Q000494:pharmacology*; D009952:Ornithine / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D004151:Dipeptides; D026901:Membrane Transport Proteins; C118598:MexA protein, Pseudomonas aeruginosa; C118597:MexB protein, Pseudomonas aeruginosa; C402263:OprM protein, Pseudomonas aeruginosa; C402264:phenylalanyl-N(alpha)-methylornithine 2-naphthyl amide; D064704:Levofloxacin; D015242:Ofloxacin; D009952:Ornithine; D010450:Endopeptidases