In-111 octreotide scan in a case of a neuroendocrine tumor of unknown origin.
Major neuroendocrine tumors contain many somatostatin receptors. This feature allows for the localization of primary tumors and tumor metastases by scintigraphy with the radiolabeled somatostatin analog octreotide. We describe a patient with nonspecific clinical data and ultrasonography and CT that showed an isolated focal lesion in the liver. In-111 octreotide scintigraphy was essential in establishing the diagnosis of liver metastasis from a neuroendocrine tumor confirmed by pathologic findings. Because clinical symptoms recurred, ultrasonography and CT were performed a few months after surgery. Both were negative. However, In-111 octreotide scintigraphy suggested multiple bone metastases and established the diagnosis of bone metastases from a neuroendocrine tumor, which was confirmed by Tc-99m MDP bone scans and MRI.
Fuster
D
D
Department of Nuclear Medicine, Hospital Clínic i Provincial, Barcelona, Spain.
Navasa
M
M
Pons
F
F
Vidal-Sicart
S
S
Mateos
J J
JJ
Lomeña
F
F
Rodes
J
J
Herranz
R
R
D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000556:secondary*; D005500:Follow-Up Studies; D006801:Humans; D007205:Indium Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D010384:Pelvic Bones / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000187:drug effects; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D015282:Octreotide; D013669:Technetium Tc 99m Medronate