1,2,3,4-tetrahydroisoquinoline derivatives; lipophilicity evaluation vs. 5-HT1A receptor affinity.
Retention parameters (log k') of 1,2,3,4-tetrahydroisoquinoline derivatives--a new class of 5-HT1A receptor ligands--were determined on the basis of reversed-phase HPLC experiments. Good correlations were found between the log k' values and the calculated log Pc, van der Waals volume of the R substituent (VR) as well as the 5-HT1A receptor affinity (Ki) of the investigated compounds. It was demonstrated that hydrophobic forces played a pivotal role in stabilizing the ligand-receptor bioactive complex for that group of compounds.
Bojarski
A J
AJ
Department of Medicinal Chemistry, Polish Academy of Sciences, Kraków, Poland.
Mokrosz
M J
MJ
D000818:Animals; D002021:Buffers; D002851:Chromatography, High Pressure Liquid; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D008055:Lipids / Q000737:chemistry; D011869:Radioligand Assay; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D002021:Buffers; D007546:Isoquinolines; D008055:Lipids; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D018490:Serotonin Agents