title: HDR-brachytherapy boost for residual tumour after external beam radiotherapy in patients with tracheal malignancies.
abstract: Seven inoperable patients with tracheal neoplasms received a high dose rate (HDR) brachytherapy boost (median 15 Gy, single dose 3-5 Gy) for residual tumour after external beam radiotherapy (median 50 Gy, 5 x 2 Gy/week). The median actuarial survival was 34.3 months. The 1-, 2- and 3-year actuarial survival rates were 85.7%, 85.7% and 32%. Local control was obtained in 5/7 patients. Late toxicity occurred in three patients (stenosis n = 2, hemorrhage n = 1). Our data indicate, that a HDR brachytherapy boost is effective and feasible.
authors.affiliation: Department of Clinical Radiology, University of Heidelberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Harms
authors.forename: D
authors.initials: D
authors.lastname: Latz
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: F
authors.initials: F
authors.lastname: Herth
authors.forename: P
authors.initials: P
authors.lastname: Schraube
authors.forename: R
authors.initials: R
authors.lastname: Krempien
authors.forename: M
authors.initials: M
authors.lastname: Wannenmacher
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D001999:Bronchoscopy; D003528:Carcinoma, Adenoid Cystic / Q000532:radiotherapy / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D002813:Chondrosarcoma / Q000532:radiotherapy / Q000601:surgery; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018365:Neoplasm, Residual / Q000532:radiotherapy; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012074:Remission Induction; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D014133:Tracheal Diseases / Q000209:etiology; D014134:Tracheal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D014135:Tracheal Stenosis / Q000209:etiology