title: Chronopharmacology of tacrolimus in rats: toxicity and efficacy in a mouse-to-rat intestinal transplant model and its pharmacokinetic profile.
authors.affiliation: Division of Organ Replacement Research, Jichi Medical School, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Uchida
authors.forename: E
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ogino
authors.forename: K
authors.initials: K
authors.lastname: Mizuta
authors.forename: H
authors.initials: H
authors.lastname: To
authors.forename: R
authors.initials: R
authors.lastname: Okabe
authors.forename: K
authors.initials: K
authors.lastname: Hashizume
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D016332:Fetal Tissue Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D007422:Intestines / Q000637:transplantation*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D014183:Transplantation, Heterologous / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus