Organogenic role of B lymphocytes in mucosal immunity.
Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers.
Golovkina
T V
TV
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Shlomchik
M
M
Hannum
L
L
Chervonsky
A
A
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002452:Cell Count; D005803:Genes, Immunoglobulin; D018928:Immunity, Mucosal; D007075:Immunoglobulin M / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation; D008324:Mammary Tumor Virus, Mouse / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008855:Microscopy, Electron, Scanning; D010581:Peyer's Patches / Q000166:cytology* / Q000276:immunology* / Q000648:ultrastructure; D012192:Retroviridae Infections / Q000276:immunology / Q000821:virology; D013601:T-Lymphocytes / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology
D007075:Immunoglobulin M