title: Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells.
abstract: The influence of polyethylene terephthalate (PET) on the release of platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (bFGF) by in vitro cultured human endothelial cells was assessed by enzyme immunoassay. No significant differences were observed in the production of PDGF-AB with respect to the negative control cultures. A significant increase was observed in the production of bFGF after 48 and 72 h with respect to the negative control cultures. It can be concluded that PET may induce an increase in the production of basic FGF in endothelial cells.
authors.affiliation: Laboratory for Biocompatibility Research on Implant Materials, Instituti Ortopedici Rizzoli, Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cenni
authors.forename: E
authors.initials: E
authors.lastname: Verri
authors.forename: D
authors.initials: D
authors.lastname: Granchi
authors.forename: S
authors.initials: S
authors.lastname: Gamberini
authors.forename: A
authors.initials: A
authors.lastname: Corradini
authors.forename: A
authors.initials: A
authors.lastname: Di Leo
authors.forename: L
authors.initials: L
authors.lastname: Montanaro
authors.forename: A
authors.initials: A
authors.lastname: Pizzoferrato
mesh_terms: D001672:Biocompatible Materials / Q000633:toxicity*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism*; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia; D007700:Kinetics; D008070:Lipopolysaccharides / Q000633:toxicity; D008422:Materials Testing; D010982:Platelet-Derived Growth Factor / Q000096:biosynthesis / Q000378:metabolism*; D011093:Polyethylene Terephthalates / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; D008070:Lipopolysaccharides; D010982:Platelet-Derived Growth Factor; D011093:Polyethylene Terephthalates; D016222:Fibroblast Growth Factor 2