title: High-performance liquid chromatography study of the enantiomer separation of chrysanthemic acid and its analogous compounds on a terguride-based stationary phase.
abstract: The direct enantioseparation of chrysanthemic acid [2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylic acid] and its halogen-substituted analogues was systematically studied by HPLC using a terguride-based chiral stationary phase in combination with a UV diode array and chiroptical detectors. Isomers with (1R) configuration always eluted before those with (IS) configuration. The elution sequence of cis- and trans-isomers was strongly affected by mobile phase pH, whereas the enantioselectivity remained the same. Conditions for the separation of all the enantiomers were also examined. This method was used for monitor the hydrolytic degradation products of Cyfluthrin (Baythroid) in soil under laboratory conditions.
authors.affiliation: Istituto di Cromatografia, CNR-Area della Ricerca di Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dondi
authors.forename: M
authors.initials: M
authors.lastname: Flieger
authors.forename: J
authors.initials: J
authors.lastname: Olsovska
authors.forename: C M
authors.initials: CM
authors.lastname: Polcaro
authors.forename: M
authors.initials: M
authors.lastname: Sinibaldi
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification*; D009570:Nitriles; D011722:Pyrethrins / Q000737:chemistry* / Q000302:isolation & purification*; D012987:Soil / Q000032:analysis; D013237:Stereoisomerism
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D012987:Soil; C007051:chrysanthemic acid; C052570:cyfluthrin