title: Environmental covariates: effects on the power of sib-pair linkage methods.
abstract: The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.
authors.affiliation: Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Mandal
authors.forename: A J
authors.initials: AJ
authors.lastname: Sorant
authors.forename: E W
authors.initials: EW
authors.lastname: Pugh
authors.forename: S E
authors.initials: SE
authors.lastname: Marcus
authors.forename: A P
authors.initials: AP
authors.lastname: Klein
authors.forename: R A
authors.initials: RA
authors.lastname: Mathias
authors.forename: J
authors.initials: J
authors.lastname: O'Neill
authors.forename: L F
authors.initials: LF
authors.lastname: Temiyakarn
authors.forename: A F
authors.initials: AF
authors.lastname: Wilson
authors.forename: J E
authors.initials: JE
authors.lastname: Bailey-Wilson
mesh_terms: D004777:Environment; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D016678:Genome; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family; D019655:Quantitative Trait, Heritable