title: [Clinical and therapeutic aspects of otogenic sepsis in the antibiotic era].
abstract: 152 cases of otogenic thrombophlebitis of the sigmoid sinus (TSS) are analysed. 128 (84.2%) patients had thrombophlebitis and sepsis, 24 (15.8%) had thrombophlebitis without sepsis. TSS occurred more frequently in combination with other intracranial complications. In conditions of wide use of antibiotics and other drugs thromboembolic and toxicoinfectious otogenic complications may run with an atypical clinical picture: with reduced symptoms, without classic manifestations of sepsis. In diagnosis such investigations as computed tomography, MR-tomography, ultrasonography may be decisive. Major diagnostic criterium in diagnosis of otogenic sepsis is polyorganic insufficiency. Otogenic thrombophlebitis and sepsis is treated first of all surgically--the purulent focus in the ear should be cleansed. Postoperative treatment includes antimicrobial drugs, immunomodulators, anticoagulants, antihistaminic, detoxicating and antiedematic medicines, UV irradiation of autoblood and hyperbaric oxygenation.
authors.forename: G A
authors.initials: GA
authors.lastname: Gadzhimirzaev
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D010035:Otitis Media, Suppurative / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D010256:Paranasal Sinuses / Q000098:blood supply* / Q000601:surgery*; D012189:Retrospective Studies; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D013924:Thrombophlebitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Klinika i osobennosti lecheniia otogennogo sepsisa v éru antibiotikov.