title: Paired Mg and Mg(B) ionization chambers for the measurement of boron neutron capture dose in neutron beams.
abstract: The use of the boron neutron capture (BNC) reaction to provide a dose enhancement in fast neutron therapy is currently under investigation at the Gershenson Radiation Oncology Center of Harper Hospital in Detroit, MI. The implementation of this treatment modality presents unique challenges in dosimetry. In addition to the measurement of photon and neutron doses in the mixed field, a measure of the thermal neutron flux and the associated boron neutron capture dose throughout the treatment volume is desired. A pair of small-volume magnesium ionization chambers has been constructed with the aim of providing this information. One of the chambers, denoted the Mg(B) chamber, is lined with a boron-loaded foil. The ionization response of this chamber has been calibrated in terms of BNC dose per ppm loading of 10B. These paired chambers can be used to map the local BNC response in neutron beams. From this data and an estimation of the boron concentration in the tumor and normal tissue, the boron neutron capture enhancement may be evaluated.
authors.affiliation: Gershenson Radiation Oncology Center, Karmanos Cancer Institute, Harper Hospital and Wayne State University, Detroit, Michigan 48201, USA. burmeist@kci.wayne.edu]
authors.forename: J
authors.initials: J
authors.lastname: Burmeister
authors.forename: C
authors.initials: C
authors.lastname: Kota
authors.forename: M
authors.initials: M
authors.lastname: Yudelev
authors.forename: R L
authors.initials: RL
authors.lastname: Maughan
mesh_terms: D001895:Boron; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation* / Q000379:methods; D002138:Calibration; D004867:Equipment Design; D019047:Phantoms, Imaging; D011879:Radiotherapy Dosage / Q000592:standards*; D015203:Reproducibility of Results
chemical_list: D001895:Boron