title: Circadian variation of plasma arginine vasopressin concentration, or arginine vasopressin in enuresis.
abstract: The objective of these studies was to determine a relationship between primary nocturnal enuresis and arginine vasopressin (AVP) secretion. The first study compared 24-h AVP secretion profiles of enuretic (n = 9) and non-enuretic children (n = 8). Blood samples were collected at 1-h intervals for 24 h. In the second study, nocturnal AVP secretion in group A (n = 40)--with low urinary osmotic pressure (UOP) and large nocturnal urine output (NUO)--was compared with that in group D (n = 11) with normal UOP and small NUO. Plasma AVP levels were measured at 30-min intervals, immediately after falling asleep until 06.00 the following morning. The results of the first study showed that the plasma AVP level was significantly lower (p < 0.05-0.001) in the enuretic group between 23.00 and 04.00. The second study showed that group A had significantly lower AVP levels (p < 0.05-0.001) than group D throughout the night. The mean AVP level during night sleep was 0.64 +/- 0.23 pg/ml in group A and 1.43 +/- 0.66 pg/ml in group D. The results of the first study suggest that decreased nocturnal AVP secretion is a cause of bedwetting. However, the results of the second study suggest that nocturnal enuresis cannot be explained by a decrease in nocturnal AVP secretion alone.
authors.affiliation: Department of Pediatrics, Niigata Prefectural Kamo Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aikawa
authors.forename: T
authors.initials: T
authors.lastname: Kasahara
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
mesh_terms: D000293:Adolescent; D001127:Arginine Vasopressin / Q000097:blood*; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D004775:Enuresis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D017286:Polysomnography; D012016:Reference Values; D012894:Sleep Stages / Q000502:physiology; D014563:Urodynamics / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D001127:Arginine Vasopressin