title: Determinants of hospital survival following reoperative single valve replacement.
abstract: OBJECTIVE
  To determine the indicators of risk for hospital death, patients undergoing reoperative valve replacement were analyzed
  
  
  METHODS
  Four hundred and eighteen consecutive patients undergoing reoperative valve replacement from 1977 to 1994 were reviewed using univariate and multivariate analysis.
  
  
  RESULTS
  Overall hospital mortality was 11.2% with 9.4% mortality with aortic valve replacement and 14.2% with mitral valve replacement (P=0.52). Mortality was 9.7% for patients less than 70 years of age compared with 19.4% for older patients (P=0.03), and was 8.5% for those with anoxia times less than 90 mins versus 21.9% for those with longer anoxia times (P=0.001). For first reoperations, 9.5% of patients died, while for patients undergoing second or more reoperation, mortality was 23.2% (P=0.01). While mortality increased from 8.9% to 19.0% with the addition of a concomitant procedure (P=0.008), it was not affected if the additional procedure was a coronary bypass (P=0. 96). The indication for surgery influenced outcome. Mortality was zero for thromboembolism, 9% for structural failure, 23% for nonstructural failure and 22% for endocarditis (P=0.006). For New York Heart Association (NYHA) functional class I patients, mortality was 1.6% compared with 22.3% for those in NYHA class IV (P=0.006). By multivariate analysis, however, only the indication for surgery and the NYHA functional class influenced survival.
  
  
  CONCLUSIONS
  Reoperative valve surgery can be performed with a survival (88.8%) that is similar to the initial procedure (91.2%). The indication for surgery and NYHA functional class alone influenced outcome; therefore, possible early reoperation is indicated before clinical deterioration occurs.
authors.affiliation: University of Ottawa Heart Institute, Ottawa, Canada.
authors.forename: I S
authors.initials: IS
authors.lastname: Gill
authors.forename: R G
authors.initials: RG
authors.lastname: Masters
authors.forename: A L
authors.initials: AL
authors.lastname: Pipe
authors.forename: V M
authors.initials: VM
authors.lastname: Walley
authors.forename: W J
authors.initials: WJ
authors.lastname: Keon
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D002423:Cause of Death; D005260:Female; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007431:Intraoperative Complications / Q000401:mortality; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D009864:Ontario / Q000453:epidemiology; D011183:Postoperative Complications / Q000401:mortality; D012086:Reoperation / Q000401:mortality; D012189:Retrospective Studies; D015996:Survival Rate