High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region.
Histone deacetylases have been described as crucial cofactors of mammalian transcriptional complexes. We have recently identified human histone deacetylase HDAC3 on chromosome 5q31 by fluorescence in situ hybridization (FISH) in a region commonly deleted in malignant myeloid disease. Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband.
Mahlknecht
U
U
Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA. Mahlknecht@em.uni-frankfurt.de
Bucala
R
R
Hoelzer
D
D
Verdin
E
E
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D000099186:Histone Deacetylase 3
D005819:Genetic Markers; D006655:Histone Deacetylases; D000099186:Histone Deacetylase 3