Signaling via vascular endothelial growth factor receptors.
Angiogenesis, or development of blood vessels from preexisting vasculature, has important functions under both normal and pathophysiological conditions. Vascular endothelial growth factor receptors 1-3, also known as flt-1, KDR, and flt-4, are endothelial cell-specific receptor tyrosine kinases which serve as key mediators of the angiogenic responses. The review focuses on the signaling pathways that are initiated from these receptors and the recently identified VEGF coreceptor neuroplilin-1.
Petrova
T V
TV
Molecular/Cancer Biology Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Makinen
T
T
Alitalo
K
K
D004730:Endothelium, Vascular / Q000502:physiology*; D005786:Gene Expression Regulation; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D039942:Neuropilin-1; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D017978:Receptors, Growth Factor / Q000378:metabolism*; D040262:Receptors, Vascular Endothelial Growth Factor; D015398:Signal Transduction
D009419:Nerve Tissue Proteins; D017978:Receptors, Growth Factor; D039942:Neuropilin-1; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor