Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40).
CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3epsilon Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses.
Pippig
S D
SD
Department of Microbiology and Immunology, University of California, San Francisco 94143, USA.
Peña-Rossi
C
C
Long
J
J
Godfrey
W R
WR
Fowell
D J
DJ
Reiner
S L
SL
Birkeland
M L
ML
Locksley
R M
RM
Barclay
A N
AN
Killeen
N
N
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000913:Antibodies, Protozoan / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D005260:Female; D018390:Gene Targeting; D007111:Immunity, Cellular / Q000235:genetics; D018320:Leishmania major / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains; D009559:Nippostrongylus / Q000276:immunology; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000096:biosynthesis* / Q000235:genetics* / Q000502:physiology
D000909:Antibodies, Helminth; D000913:Antibodies, Protozoan; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; C505717:Tnfrsf4 protein, mouse; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7