title: An Au nanoparticle/bisbipyridinium cyclophane-functionalized ion-sensitive field-effect transistor for the sensing of adrenaline.
abstract: A film consisting of polyethyleneimine (PEI), Au nanoparticles (12 +/- 1 nm) and coadsorbed cyclobis(paraquat-p-phenylene) (1) was assembled as a sensing interface on the Al2O3 insulating layer of an ion-sensitive field-effect transistor (ISFET). Adrenaline (2) was sensed by the functionalized ISFET with a detection limit of 1 x 10(-6) M. The sensing ability of the nanostructured device for the analysis of adrenaline originates from the preconcentration of the analyte in the cyclophane by pi-pi donor-acceptor interactions. Analysis of adrenaline is accomplished by the measurement of the source-drain current, Isd, or by the gate-source voltage, Vgs. The sensing device is reusable (at least 100 cycles) and exhibits high stability.
authors.forename: A B
authors.initials: AB
authors.lastname: Kharitonov
authors.forename: A N
authors.initials: AN
authors.lastname: Shipway
authors.forename: I
authors.initials: I
authors.lastname: Willner
mesh_terms: D004837:Epinephrine / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D007477:Ions; D011726:Pyridinium Compounds / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D007477:Ions; D011726:Pyridinium Compounds; D006046:Gold; D004837:Epinephrine