[Structural-functional changes in biomembranes during complications of diabetes mellitus and their pharmacological correction].
The decrease of sorbitol dehyidrogenase activity and the increase both of aldoso reductase activity and sorbitol concentration in aorta or eye lens under experimental diabetic angiopathy have been shown. The structural and functional alterations in erythrocytes membranes under angiopathy studied by spin- and luminesoense probes confirm the hypothesis on the major role of membrane pathology processes in the pathogenesis of diabetic mellitus. Pharmacological correction of diabetic angiopathy by glucophag or new antioxidant LBK-78 normalized the studied diversions on the membranes level.
Tat'ianenko
L V
LV
Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka.
Bogdanov
G N
GN
Varfolomeev
V N
VN
Kotel'nikova
R A
RA
Shaposhnikova
G I
GI
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003925:Diabetic Angiopathies / Q000188:drug therapy / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D009930:Organic Chemicals; D051381:Rats; D013012:Sorbitol / Q000378:metabolism
D000975:Antioxidants; D007004:Hypoglycemic Agents; C404947:LBK 78; D009930:Organic Chemicals; D013012:Sorbitol; D008687:Metformin
Strukturno-funktsional'nye izmeneniia biomembran pri oslozhneniiakh sakharnogo diabeta i ikh farmakologicheskaia korrektsiia.