Recent concepts in the neurophysiology of pain.
This paper describes many of the processes that exist for upregulation of the nociceptive system in response to tissue injury. The processes of peripheral and central sensitization are described. Potential interactions between the nociceptive, motor and autonomic systems are considered. The potential for psychosocial factors to influence neuroplasticity within the nociceptive system is also discussed.
Wright
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School of Medical Rehabilitation, Faculty of Medicine, University of Manitoba, Canada.
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009132:Muscles / Q000294:innervation / Q000378:metabolism / Q000503:physiopathology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000378:metabolism / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D015854:Up-Regulation