title: Combination treatment of rheumatoid arthritis with cyclosporine and methotrexate.
abstract: In patients with rheumatoid arthritis (RA) not controlled on methotrexate (MTX) alone, clinical trials have shown that combination therapy with cyclosporine (CSA) and MTX is effective and relatively well tolerated over 12 months. Information regarding the long-term benefits, toxicities and tolerability of this combination therapy in clinical practice, and comparisons with alternative strategies, will determine the utility of the MTX plus CSA combination regimen in patients with RA not controlled with a single drug.
authors.affiliation: Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Stein
authors.forename: T
authors.initials: T
authors.lastname: Pincus
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D018501:Antirheumatic Agents; D016572:Cyclosporine; D008727:Methotrexate