title: The ABCA subclass of mammalian transporters.
abstract: We describe here a subclass of mammalian ABC transporters, the ABCA subfamily. This is a unique group that, in contrast to any other human ABC transporters, lacks a structural counterpart in yeast. The structural hallmark of the ABCA subfamily is the presence of a stretch of hydrophobic amino acids thought to span the membrane within the putative regulatory (R) domain. As for today, four ABCA transporters have been fully characterised but 11 ABCA-encoding genes have been identified. ABCA-specific motifs in the nucleotide binding folds can be detected when analysing the conserved sequences among the different members. These motifs may reveal functional constraints exclusive to this group of ABC transporters.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, 13288, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Broccardo
authors.forename: M
authors.initials: M
authors.lastname: Luciani
authors.forename: G
authors.initials: G
authors.lastname: Chimini
mesh_terms: D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000145:classification* / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000235:genetics; D005128:Eye Diseases / Q000235:genetics; D016678:Genome; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D007448:Invertebrates; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000737:chemistry
chemical_list: C056475:ABCA4 protein, human; D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; C112887:CED-7 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D006023:Glycoproteins; D009711:Nucleotides; C081168:abcA protein, Aeromonas salmonicida