Anti-CD8 treatment alters interleukin-4 but not interferon-gamma mRNA levels in murine sensory ganglia during herpes simplex virus infection. Brief report.
Clearance of herpes simplex virus (HSV) from sensory ganglia of infected mice is dependent on CD8(+) cells but not on the death of infected neurons. The mechanism of action of CD8(+) cells in HSV infected ganglia is therefore unknown. The determine which cytokines might be involved in the CD8(+) cell dependent response to ganglionic HSV infection, IL-2, IL-4, IL-6, IL-10, and IFN-gamma mRNA levels were measured in infected ganglia from immunocompetent and anti-CD8 treated mice. Anti-CD8 treatment increased the abundance of mRNA encoding IL-4, and, to a lesser extent, IL-2, and IL-6. Significantly, IFN-gamma mRNA was not affected.
Tscharke
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DC
Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, Australia.
Simmons
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A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000911:Antibodies, Monoclonal; D016827:CD8 Antigens; D016207:Cytokines; D012333:RNA, Messenger; D015847:Interleukin-4; D007371:Interferon-gamma