Stereoselective Mukaiyama-Michael/Michael/Aldol Domino Cyclization as the Key Step in the Synthesis of Pentasubstituted Arenes: An Efficient Access to Highly Active Inhibitors of Cholesteryl Ester Transfer Protein (CETP).
Seemingly heartbreaking for a stereochemist, the one-step selective construction of a stereopentad and its prompt destruction by aromatization has been proven to be an efficient strategy for the synthesis of fivefold substituted, pharmacologically highly active arenes (see scheme).
Paulsen
H
Bayer AG, Pharmaforschung, PH-R-CF Chemisch-wissenschaftliches Laboratorium, D-42096 Wuppertal (Germany).
Antons
S
Brandes
A
Lögers
M
Müller
SN
Naab
P
Schmeck
C
Schneider
S
Stoltefuß
J