Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis.
The distributions of the bi-allelic interleukin-1beta+3953 and tumor necrosis factor-alpha-308 genotypes were determined in 20 patients with advanced adult periodontitis, 20 patients with plaque associated gingivitis, and 45 referent population subjects. A significant increase in IL-1beta+3953 allele 2 frequency was found in patients with advanced periodontitis compared to referent subjects (the Fisher exact test; p=0.013). Furthermore, the frequency of TNF-alpha-308 allele 1 was significantly greater in patients with advanced disease compared to those with plaque associated gingivitis (the Fisher exact test; p=0.014). No significant correlation was observed between genotype and cytokine production in these patient populations.
Galbraith
G M
GM
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425, USA. galbragm@musc.edu
Hendley
T M
TM
Sanders
J J
JJ
Palesch
Y
Y
Pandey
J P
JP
D000328:Adult; D000368:Aged; D000483:Alleles; D015415:Biomarkers; D016022:Case-Control Studies; D003773:Dental Plaque / Q000150:complications; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D005891:Gingivitis / Q000209:etiology / Q000235:genetics; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000166:cytology / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010518:Periodontitis / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D015415:Biomarkers; D005819:Genetic Markers; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha