Oxidized LDL and expression of monocyte adhesion molecules.
Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.
Kita
T
T
Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan. tkita@kuhp.kyoto-u.ac.jp
Kume
N
N
Ishii
K
K
Horiuchi
H
H
Arai
H
H
Yokode
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood; D008077:Lipoproteins, LDL / Q000494:pharmacology / Q000502:physiology*; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D011973:Receptors, LDL / Q000502:physiology; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E
D015815:Cell Adhesion Molecules; D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; C495137:OLR1 protein, human; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein