title: Propofol-nitrous oxide versus sevoflurane-nitrous oxide for strabismus surgery in children.
abstract: Vomiting is a common problem following strabismus surgery. We compared the effects of propofol-N2O and sevoflurane-N2O on the incidence of oculocardiac reflex and postoperative nausea and vomiting. Forty unpremedicated children, aged 3-15 years were randomly assigned to two groups of 20 patients. In group 1, anaesthesia was induced and maintained with propofol infusion (173 +/- 41 micrograms.kg-1.min-1). In group 2, anaesthesia was induced with N2O (66%) in O2 and incremental sevoflurane via face mask and maintained with sevoflurane. Both groups received 66% N2O in O2 throughout surgery. The overall incidence of vomiting and antiemetic requirement in the first 24 h was significantly higher in sevoflurane-N2O group than propofol-N2O group (P < 0.05). The propofol-N2O group had significantly more episodes of oculocardiac reflex than sevoflurane-N2O group (P < 0.05). Propofol-N2O anaesthesia results in a significantly lower incidence of postoperative vomiting, yet a significantly higher incidence of oculocardiac reflex.
authors.affiliation: Department of Anaesthesiology and Reanimation, Kocaeli University Hospital, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Gürkan
authors.forename: L
authors.initials: L
authors.lastname: Kiliçkan
authors.forename: K
authors.initials: K
authors.lastname: Toker
mesh_terms: D000293:Adolescent; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D018686:Anesthetics, Intravenous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects; D009609:Nitrous Oxide / Q000009:adverse effects; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced; D015742:Propofol / Q000009:adverse effects; D012024:Reflex, Oculocardiac / Q000187:drug effects; D000077149:Sevoflurane; D013285:Strabismus / Q000601:surgery*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D009609:Nitrous Oxide; D015742:Propofol