title: Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties.
abstract: Tc-D,D- and TC-L,L-HMPAO were synthesized. The stability of Tc-D,D- and TC-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higer than the D,D- and d,l-isomer in rats. Delayed studies shows that T-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer.
authors.affiliation: Department of Nuclear Medicine, School of Technology for Medical Sciences, Kaohsiung Medicial University, Taiwan.
authors.forename: H J
authors.initials: HJ
authors.lastname: Ding
authors.forename: Y F
authors.initials: YF
authors.lastname: Huang
authors.forename: C C
authors.initials: CC
authors.lastname: Tzeng
authors.forename: L M
authors.initials: LM
authors.lastname: Wei
authors.forename: S J
authors.initials: SJ
authors.lastname: Yeh
mesh_terms: D000818:Animals; D005260:Female; D007536:Isomerism; D051381:Rats; D017208:Rats, Wistar; D019690:Technetium Tc 99m Exametazime / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019690:Technetium Tc 99m Exametazime