title: [Radical prostatectomy in prostate adenocarcinoma. Clinical factors influencing the pathological stage. Diagnostic model].
abstract: METHODS
  Study on the efficacy of stage diagnosis, how to support it based on clinical objective data and description of a prognostic model. Analysis of 160 patients diagnosed with localized prostate adenocarcinoma undergoing radical prostatectomy in the Clínica Universitaria de Navarra between 1988-1997. The statistical study used Fisher's or Pearson's tests for the comparison of qualitative variables. A logistic regression multivariate analysis was run to avoid confounding factors in the pathological stage.
  
  
  RESULTS
  85/160 (53%) were correctly staged. Incorrect staging occurred in patients with higher clinical stage (T1-T2a: 25%; T2bc: 65%). The univariate study shows that the pathological stage is significantly correlated to: a) serum PSA levels (15 ng/mL in P2 vr. 25 ng/mL in P3-4), the most suitable cutoff value being 15 ng/mL. b) digital rectal examination and Gleason. Negatively influencing factors in the multivariate study were: PSA greater than 15 ng/mL, Gleason greater than 5 and a T2bc clinical stage. Risk groups: 4 risk groups are established based on the above factors (inclusion in group 1 involves an 8% risk of having P3, 30% in group 2, 56% in group 3 and 84% in group 4).
  
  
  CONCLUSIONS
  The clinical factors with influence in the pathological stage are PSA, Gleason and clinical stage. The reliability of the risk groups established based on these factors is remarkable.
authors.affiliation: Servicio de Urología, Clínica Universitaria de Navarra, Universidad de Navarra, Pamplona.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire Bergera
authors.forename: A
authors.initials: A
authors.lastname: Martín-Marquina Aspiunza
authors.forename: D
authors.initials: D
authors.lastname: Sánchez Zalabardo
authors.forename: J
authors.initials: J
authors.lastname: Arocena García-Tapia
authors.forename: G
authors.initials: G
authors.lastname: Sanz Pérez
authors.forename: F
authors.initials: F
authors.lastname: Díez-Caballero Alonso
authors.forename: D
authors.initials: D
authors.lastname: Rosell Costa
authors.forename: J E
authors.initials: JE
authors.lastname: Robles García
authors.forename: J M
authors.initials: JM
authors.lastname: Berián Polo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D016015:Logistic Models; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D012306:Risk
vernacular_title: Prostatectomía radical en adenocarcinoma de próstata. Factores clínicos influyentes en el estadio patológico. Modelo diagnóstico.