L-selectin in trauma patients: a marker for organ dysfunction and outcome?
BACKGROUND
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are important factors affecting morbidity and mortality after trauma. Adhesion molecules, e.g. L-selectin (CD62 L), play crucial roles in both conditions.


METHODS
In 51 multiple trauma patients, CD62 L surface expression on granulocytes, monocytes, lymphocytes, as well as sCD62 L plasma concentrations were determined during the first 6 days after trauma, starting at the site of accident. Clinical parameters were severity of injury scores (ISS, APACHE II), requirement of red blood cell transfusion, acute lung or liver failure, development of MODS or SIRS, early (< or = 6 d) or late (> 6 d), and outcome.


RESULTS
CD62 L expression was reversibly elevated on granulocytes, T cells and monocytes in comparison with initial values. sCD62 L plasma concentrations did not show temporal variations but were depressed throughout observation period, in comparison with healthy controls. Lung failure within the first 6 days was associated with increased CD62 L expression on monocytes and B cells on admission and increased sCD62 L concentrations after 12 and 24 h. Patients with more severe injuries (APACHE II > 20 points) had higher sCD62 L concentrations after 24 h. Non-survivors had decreased sCD62 L (on admission) and T-cell CD62 L expression (after 4 h). Patients with early MODS or SIRS showed increased monocyte CD62 L expression after 6 days.


CONCLUSIONS
In multiple trauma patients, severe organ dysfunction is associated with altered CD62 L expression on leukocytes and circulating sCD62 L plasma concentrations. However, the obvious complexity of the pattern currently restricts use of CD62 L quantitation for clinical purposes.
Kerner
T
T
Department of ANesthesiology and Intensive Care Medicine, Charité Medical Center, Virchow Hospital, Humboldt University, Berlin, Germany.
Ahlers
O
O
Spielmann
S
S
Keh
D
D
Bührer
C
C
Gerlach
M
M
Höfler
S
S
Gerlach
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D003710:Demography; D005260:Female; D006801:Humans; D007118:Immunoassay; D019041:L-Selectin / Q000097:blood* / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology / Q000378:metabolism / Q000401:mortality; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000378:metabolism / Q000401:mortality
D015415:Biomarkers; D019041:L-Selectin