title: Assessing linkage of monoamine oxidase B in a genome-wide scan using a univariate variance components approach.
abstract: We report results when one alcoholism related quantitative trait, monoamine oxidase B (MAOB), is analyzed by the variance components approach for linkage [Amos, 1994; Amos et al., 1996] using the Collaborative Study on the Genetics of Alcoholism data set provided for the Genetic Analysis Workshop 11. We used two different covariate models, one with age at interview, sex, ethnicity, and smoking status and the other with age at interview, sex, and ethnicity. The univariate analysis showed 24 markers on four different chromosomes (1, 4, 9, and 12) to have evidence for linkage with the quantitative trait (single-point and multipoint linkage). However, when outliers for MAOB were removed, the significant evidence for linkage disappeared.
authors.affiliation: Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Barnholtz
authors.forename: M
authors.initials: M
authors.lastname: de Andrade
authors.forename: G P
authors.initials: GP
authors.lastname: Page
authors.forename: T M
authors.initials: TM
authors.lastname: King
authors.forename: L E
authors.initials: LE
authors.lastname: Peterson
authors.forename: C I
authors.initials: CI
authors.lastname: Amos
mesh_terms: D002878:Chromosomes, Human, Pair 1; D002881:Chromosomes, Human, Pair 12; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D005192:Family Health; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008126:Lod Score; D008995:Monoamine Oxidase / Q000235:genetics*; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers; D008995:Monoamine Oxidase