title: Use of intra-articular morphine for postoperative analgesia following TMJ arthroscopy.
abstract: Recent studies have suggested that giving opioids locally into inflamed tissue may cause analgesia. This antinociceptive effect has been attributed to the interaction of the drug with opioid receptors upregulated by inflammation in the peripheral tissues. We have compared the analgesic effect of intra-articular morphine with that of normal saline and a combination of morphine and its antagonist naloxone after arthroscopy of the temporomandibular joint (TMJ). Twenty-one patients took part in a randomized controlled double-blind trial and received one of these three solutions at the end of operation. The pain scores, time to the first request for analgesia, and the analgesic consumption of the patients in the three groups did not differ significantly at any time during the study period.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Eastman Dental and University College Hospitals, London, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bryant
authors.forename: S D
authors.initials: SD
authors.lastname: Harrison
authors.forename: C
authors.initials: C
authors.lastname: Hopper
authors.forename: M
authors.initials: M
authors.lastname: Harris
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000704:Analysis of Variance; D001182:Arthroscopy; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009270:Naloxone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D010147:Pain Measurement / Q000379:methods / Q000706:statistics & numerical data; D010149:Postoperative Pain / Q000188:drug therapy*; D011182:Postoperative Care / Q000379:methods*; D018709:Statistics, Nonparametric; D013704:Temporomandibular Joint / Q000601:surgery*; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine