title: Evaluation of transmyocardial laser revascularization (TMLR) by gated myocardial perfusion scintigraphy.
abstract: TMLR is a novel treatment for patients with coronary artery disease. It comprises the creation of transmyocardial channels thought to improve myocardial perfusion. Gated Tc-99m sestamibi scintigraphy was used to evaluate changes in myocardial perfusion after TMLR. Twelve patients underwent TMLR using a carbon dioxide laser. Sestamibi scans were carried out following a standard protocol prior to and 1, 3, 6, and 12 months after TMLR. Both visual and semi-quantitative assessment showed improvement in 4 patients, deterioration in 2 patients, and no change in the remaining 6 patients each. However, visual and semi-quantitative assessment were concordant in 6 patients and discordant in 6 patients. In 3 of these, semi-quantitative assessment suggested a better outcome, and in 3 patients visual assessment gave better results. Our findings in a small group of patients suggest that about a third benefited from TMLR. Gated myocardial perfusion scintigraphy using technetium-99m sestamibi is suitable for visual evaluation of changes in the lased area over time, but does not allow semi-quantitative evaluation in the patient population typically treated with TMLR. Further investigations using optimized imaging protocols, including positron emission tomography and three dimensional image presentation, are warranted.
authors.affiliation: Department of Nuclear Medicine, University of Dresden, Germany. tgruning@rcs.urz.tu-dresden.de
authors.forename: T
authors.initials: T
authors.lastname: Grüning
authors.forename: J
authors.initials: J
authors.lastname: Kropp
authors.forename: S
authors.initials: S
authors.lastname: Wiener
authors.forename: W G
authors.initials: WG
authors.lastname: Franke
authors.forename: S M
authors.initials: SM
authors.lastname: Tugtekin
authors.forename: V
authors.initials: V
authors.lastname: Gulielmos
authors.forename: S
authors.initials: S
authors.lastname: Schüler
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D005069:Evaluation Studies as Topic; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015425:Myocardial Reperfusion / Q000379:methods*; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi