Novel tests for marker-disease association using the Collaborative Study on the Genetics of Alcoholism data.
We applied several novel tests for association and linkage in the presence of association to the Genetic Analysis Workshop 11 Problem 1 data set. Our analyses included a Hardy-Weinberg test for association between a marker and a disease susceptibility locus, a Bayesian transmission/disequilibrium test, and a Bayesian case-control test. Positive results for each of these methods require the presence of population association between the marker and a disease susceptibility locus.
Nielsen
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Program in Statistical Genetics, North Carolina State University, Raleigh 27695-8203, USA.
Zaykin
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D000437:Alcoholism / Q000235:genetics*; D000465:Algorithms; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D015810:Linkage Disequilibrium; D044465:White People / Q000235:genetics
D005819:Genetic Markers