Activation of erythropoietin signaling by receptor dimerization.
The hormone erythropoietin (Epo) is essential for red blood cell development. Epo binds a high affinity receptor on the surface of erythroid progenitor cells, stimulating receptor dimerization and activation of the intracellular signal transduction pathways that support erythroid cell survival, proliferation and differentiation. Biochemical and structural analysis of the erythropoietin receptor (EpoR) is revealing the molecular mechanisms of EpoR function, leading the way to the development of small molecule Epo mimetics. This review focuses on the role EpoR dimerization plays in receptor function.
Watowich
S S
SS
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston 77030, USA. swatowic@notes.mdacc.tmc.edu
D000818:Animals; D019281:Dimerization; D004921:Erythropoietin / Q000737:chemistry / Q000378:metabolism*; D005544:Forecasting; D006801:Humans; D016297:Mutagenesis, Site-Directed; D011487:Protein Conformation; D017467:Receptors, Erythropoietin / Q000235:genetics / Q000378:metabolism*; D011986:Receptors, Somatotropin / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D017467:Receptors, Erythropoietin; D011986:Receptors, Somatotropin; D004921:Erythropoietin