Molecular basis of defence against oxidative stress in Entamoeba histolytica and Giardia lamblia.
Gastrointestinal protozoa, viz. Entamoeba histolytica and Giardia, are able to survive in a microaerobic environment. The role of parasitic factors, particularly cysteine, cysteine-rich proteins, superoxide dismutase, and certain alternative mechanisms, has been described in the defence against oxidative stress. The role of the host-derived factors, particularly the phagocytosis of bacteria or host erythrocytes (intact or their enzymatic/non enzymatic components), in the detoxification of reactive oxygen metabolites in E. histolytica may provide novel approaches for the chemotherapy of invasive amoebiasis.
Tekwani
B L
BL
Division of Biochemistry, Central Drug Research Institute, Lucknow-226 001 (UP), India.
Mehlotra
R K
RK
D000818:Animals; D004748:Entamoeba histolytica / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism* / Q000472:pathogenicity; D016829:Giardia lamblia / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism* / Q000472:pathogenicity; D006790:Host-Parasite Interactions; D006801:Humans; D018384:Oxidative Stress