title: Neurodevelopmental outcome in children with intrauterine growth retardation: a 3-year follow-up.
abstract: The study was designed to detect early clinical predictors of developmental outcome in children with intrauterine growth retardation. Eighty-five children with intrauterine growth retardation were followed up prospectively to 3 years of age, using biometric parameters, perinatal risk questionnaires, and neurodevelopmental evaluations. Forty-two children served as controls. A significant difference in neurodevelopmental score at 3 years of age was noted between the intrauterine growth retardation and control groups (P < .001). In the intrauterine growth retardation group, the clinical parameters that most significantly correlated with outcome were cephalization index (head circumference:birthweight ratio), neonatal risk score, and birthweight. The best predictor of 3-year outcome was the cephalization index (P < .01). The children with intrauterine growth retardation with neonatal complications had significantly lower IQ scores (P < .05) and a poorer neurodevelopmental outcome (P < .01) than those without complications. Children with intrauterine growth retardation are at higher risk for developmental disabilities than are controls, especially in the presence of neonatal complications and a high cephalization index.
authors.affiliation: Institute for Child Development, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Fattal-Valevski
authors.forename: Y
authors.initials: Y
authors.lastname: Leitner
authors.forename: M
authors.initials: M
authors.lastname: Kutai
authors.forename: E
authors.initials: E
authors.lastname: Tal-Posener
authors.forename: A
authors.initials: A
authors.lastname: Tomer
authors.forename: D
authors.initials: D
authors.lastname: Lieberman
authors.forename: A
authors.initials: A
authors.lastname: Jaffa
authors.forename: A
authors.initials: A
authors.lastname: Many
authors.forename: S
authors.initials: S
authors.lastname: Harel
mesh_terms: D016022:Case-Control Studies; D002508:Cephalometry; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development*; D007360:Intelligence; D008297:Male; D008403:Mass Screening / Q000379:methods; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment