title: Treatment strategies for postoperative Propionibacterium acnes endophthalmitis.
abstract: OBJECTIVE
  Propionibacterium acnes endophthalmitis after cataract extraction and posterior chamber intraocular lens (IOL) implantation is characterized by a chronic indolent course, frequently associated with recurrence after standard endophthalmitis treatment. This study was designed to evaluate the efficacy of various therapeutic methods in the treatment of primary and recurrent episodes of postoperative P. acnes endophthalmitis.
  
  
  METHODS
  Retrospective, noncomparative case series.
  
  
  METHODS
  Twenty-five patients treated at Wills Eye Hospital for P. acnes endophthalmitis.
  
  
  METHODS
  The authors retrospectively reviewed the clinical charts and microbiology files of all patients treated at Wills Eye Hospital between January 1991 and April 1998 with culture-proven P. acnes endophthalmitis after cataract extraction and posterior chamber IOL implantation.
  
  
  METHODS
  Results of cultures and microbiologic examinations, efficacy of various treatment methods in the prevention of recurrent inflammatory episodes, and final visual outcome.
  
  
  RESULTS
  Twenty-five patients who met inclusion criteria were identified; initial therapy consisted of 1 of the following: intraocular antibiotic (IOAB) injections alone (2 patients); IOAB combined with pars plana vitrectomy (PPV) (10 patients); IOAB and PPV combined with partial capsulectomy (9 patients); and IOAB, PPV, total capsulectomy, and IOL exchange (4 patients). Nearly half of the patients (10 of 21, or 48%) initially treated with IOAB alone (1 of 2), IOAB and PPV (5 of 10), and IOAB combined with PPV and partial capsulectomy (4 of 9) required further therapeutic interventions for recurrent disease. Retreatment with IOAB alone or combined with PPV and partial capsulectomy in these patients failed to eradicate the infection in three (75%) of four patients. None of the patients (0 of 4) treated initially with total capsulectomy and IOL exchange required additional surgical intervention. Furthermore, none of the patients (0 of 13) who underwent total capsulectomy with IOL removal or exchange or IOL exchange alone as an initial, secondary, or tertiary treatment required further intervention.
  
  
  CONCLUSIONS
  In the authors' series, approximately half of the patients with P. acnes endophthalmitis were treated successfully initially with nonsurgical or limited surgical intervention. All patients treated with total capsulectomy and IOL exchange or removal, either as an initial treatment or for recurrent disease, were cured. Removal of the entire capsular bag and the IOL may be performed as a definitive initial therapy and should be performed for recurrent inflammation.
authors.affiliation: Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Aldave
authors.forename: J D
authors.initials: JD
authors.lastname: Stein
authors.forename: V A
authors.initials: VA
authors.lastname: Deramo
authors.forename: G K
authors.initials: GK
authors.lastname: Shah
authors.forename: D H
authors.initials: DH
authors.lastname: Fischer
authors.forename: J I
authors.initials: JI
authors.lastname: Maguire
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002387:Cataract Extraction / Q000009:adverse effects*; D003131:Combined Modality Therapy; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000601:surgery; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D014640:Vancomycin / Q000627:therapeutic use; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin