The disposition and metabolism of 1,3-dibromobenzene in the rat.
The distribution, excretion and metabolism of 1,3-dibromobenzene following a single i.p. administration to rats 100 or 300 mg/kg was investigated using radiotracer [3H] and GC-MS technique. After 72 hours about 74 to 90% were excreted in urine. The highest radioactivity was observed in the liver, kidneys and fat tissue. Later on a steady decline of radioactivity was apparent in all investigated tissues except for blood cells and the sciatic nerve, where constant levels were noted. In urine the following substances were identified and quantified by GC peak areas: unchanged 1,3-DBB (18%), dibromophenols (34%), dibromothiophenols (28%), dibromothioanisole (1.8%), bromophenol (5.5%), bromohydroxythiophenols (5%), and bromohydroxythioanisole (7.5%).
Sapota
A
A
Department of Toxicological Chemistry, Medical University of Lódź.
Szymańska
J A
JA
Czerski
B
B
Piotrowski
J K
JK
D000042:Absorption; D000818:Animals; D001711:Biotransformation; D001969:Bromobenzenes / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics* / Q000652:urine; D005243:Feces / Q000737:chemistry; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007274:Injections, Intraperitoneal; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014316:Tritium
D001969:Bromobenzenes; D004785:Environmental Pollutants; D014316:Tritium; C102880:1,3-dibromobenzene