[Efficiency of polysaccharide translam for early treatment of acute radiation illness].
Antiradiation therapeutic efficiency of translam (1-->3; 1-->6-beta-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD90). The preparation is nontoxic and has a broad therapeutic range which permits its practical application.
Chertkov
K S
KS
State Research Centre of Russia-Institute of Biophysics, Moscow. ibphgen@rcibph.dol.ru
Davydova
S A
SA
Nesterova
T A
TA
Zviagintseva
T N
TN
Eliakova
L A
LA
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005936:Glucans / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D000882:Haplorhini; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005936:Glucans; C033671:epiglucan
Effektivnost' polisakharida translama kak sredstva rannego lecheniia ostroĭ luchevoĭ bolezni.