The Epstein-Barr virus: a group 1 carcinogen?
The Epstein-Barr virus (EBV) is a human herpes virus with the ability to transform B-lymphocytes in vitro. EBV has been linked to the pathogenesis of a variety of human tumours, including Burkitt's lymphoma, immunosuppression-related lymphomas, Hodgkin's disease, nasal angiocentric T/NK-cell lymphoma and nasopharyngeal carcinoma. Based on the association of the virus with these tumours, EBV has been classified as a group 1 carcinogen by the WHO International Agency for Research on Cancer. In this article, the evidence suggesting that EBV is carcinogenic to humans is briefly reviewed.
Niedobitek
G
G
Pathologisches Institut, Friedrich-Alexander-Universität, Erlangen. gerald.niedobitek@patho.med.uni-erlangen.de
D002277:Carcinoma / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D008223:Lymphoma / Q000821:virology; D009369:Neoplasms / Q000821:virology*