Screening of Korean plants against human immunodeficiency virus type 1 protease.
With the aim of finding novel anti-human immunodeficiency virus agents from natural products, 93 MeOH extracts of Korean plants were screened for their inhibitory activities against HIV-1 protease. The most potent inhibition was shown by the root of Rodiola rosea with 70.4% inhibition at a concentration of 100 microg/mL.
Min
B S
BS
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea.
Bae
K H
KH
Kim
Y H
YH
Miyashiro
H
H
Hattori
M
M
Shimotohno
K
K
D002851:Chromatography, High Pressure Liquid; D016333:HIV Protease / Q000187:drug effects*; D017320:HIV Protease Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D007723:Korea; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D017320:HIV Protease Inhibitors; D010936:Plant Extracts; D016333:HIV Protease