Aggregation inhibitory activity of minor acetophenones from Paeonia species.
Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid. They were more potent than the major compound, paeonol (1), and 7 also inhibited the formation of TXA2 and PGD2 from arachidonic acid.
Lin
H C
HC
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. hcl@ndmcl.ndmctsgh.edu.tw
Ding
H Y
HY
Ko
F N
FN
Teng
C M
CM
Wu
Y C
YC
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits
D000098:Acetophenones; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid