Accumulation of plasma reduced folates after folic acid administration.
The pharmacokinetics of folic acid, and resultant metabolites thereof, have been determined after administration orally and intravenously at 25 mg/m2 and 125 mg/m2. Saturation behavior was observed for uptake of folic acid into plasma and with regard to metabolism to methylenetetrahydrofolate and tetrahydrofolate as well as methyltetrahydrofolate. Repetitive oral administration every 6 hours resulted in consistently elevated levels of each metabolite pool with the same general saturation behavior as observed with single dose administration. This repetitive oral administration is concluded to be a suitable means to provide uniform elevation of metabolites that could offer protection from undesirable toxic effects of drugs such as MTA.
Priest
D G
DG
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29425, USA.
Schmitz
J C
JC
Bunni
M A
MA
D000284:Administration, Oral; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous
D000964:Antimetabolites, Antineoplastic; D005493:Folic Acid Antagonists; D005492:Folic Acid