title: [How can "significance" be combined with "relevance"?].
abstract: Clinical trials are aimed at providing results which enable improvements in patient care. It is widely criticized, however, that the characterization of results as "significant" or "non-significant" does not allow any assessment of their clinical relevance. To counter this criticism 2 biostatistical concepts are available: the use of confidence intervals and the application of statistical tests with shifted null-hypotheses. Possibilities and limitations of these concepts are discussed in this contribution.
authors.affiliation: Abteilung für Medizinische Biometrie, Universitätsklinikum Heidelberg.
authors.forename: J
authors.initials: J
authors.lastname: Windeler
authors.forename: C
authors.initials: C
authors.lastname: Conradt
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D003627:Data Interpretation, Statistical; D019317:Evidence-Based Medicine / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012107:Research Design; D012680:Sensitivity and Specificity
vernacular_title: Wie können "Signifikanz" und "Relevanz" verbunden werden?