title: Current studies on the pathogenesis of melioidosis.
abstract: Burkholderia pseudomallei is a major cause of bacterial septicemias in many parts of the world, particularly Thailand; the known geographic range of the organism appears to be enlarging as awareness of the organism and the disease it causes--melioidosis--increases. B. pseudomallei is intrinsically resistant to most antibiotics, and our knowledge of B. pseudomallei pathogenesis is lacking. Thus, the long-term objective of our research is to define at a molecular level the pathogenesis by combining genetic, immunologic, and biochemical approaches with animal model studies. Basic studies on B. pseudomallei pathogenesis are acutely needed to provide a knowledge base to rationally design new modes of therapy directed against this organism.
authors.affiliation: Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Centre, 3330 Hospital Drive, NW, Calgary, Alberta T2N 4N1, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Woods
authors.forename: D
authors.initials: D
authors.lastname: DeShazer
authors.forename: R A
authors.initials: RA
authors.lastname: Moore
authors.forename: P J
authors.initials: PJ
authors.lastname: Brett
authors.forename: M N
authors.initials: MN
authors.lastname: Burtnick
authors.forename: S L
authors.initials: SL
authors.lastname: Reckseidler
authors.forename: M D
authors.initials: MD
authors.lastname: Senkiw
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion; D016957:Burkholderia pseudomallei / Q000187:drug effects / Q000472:pathogenicity* / Q000502:physiology; D002478:Cells, Cultured / Q000382:microbiology; D003165:Complement System Proteins / Q000494:pharmacology; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D005798:Genes, Bacterial; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D013785:Thailand; D014774:Virulence / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D003165:Complement System Proteins