Linkage and association study of the CTLA-4 region in coeliac disease for Italian and Tunisian populations.
Coeliac disease (CD) is a multifactorial disease for which there is an intensive search for genetic risk factors. Some authors found an association between the CTLA-4 region and CD. In the present work, we investigate the possible implication of the CTLA-4 region as a genetic risk factor for CD, through two statistical approaches: the maximum likelihood score (MLS) test in a large Italian sample of affected sib-pairs using polymorphic genetic markers on chromosome 2, and the transmission disequilibrium test (TDT) in continental Italian and Tunisian families using the CTLA-4 exon 1 49 A/G polymorphism. None of these approaches provides evidence for linkage or association between the CTLA-4 region and CD. This might result from a difference in the CTLA-4 region from population to population, either in its involvement as a risk factor or in the strength of linkage disequilibrium.
Clot
F
F
Laboratoire de Cytogénétique et Génétique Moléculaire Humaine, Université de Versailles, France. Fabienne.Clot@cytogene.uvsq.fr
Fulchignoni-Lataud
M C
MC
Renoux
C
C
Percopo
S
S
Bouguerra
F
F
Babron
M C
MC
Djilali-Saiah
I
I
Caillat-Zucman
S
S
Clerget-Darpoux
F
F
Greco
L
L
Serre
J L
JL
D000069594:Abatacept; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D018796:Immunoconjugates; D007558:Italy; D008297:Male; D011110:Polymorphism, Genetic; D014416:Tunisia
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D005819:Genetic Markers; D018796:Immunoconjugates; D000069594:Abatacept