title: Keratotsis punctata of the palmar creases: report of two cases associated with ichthyosis vulgaris.
abstract: Two patients with keratosis punctata of the palmar creases are described. The association with ichthyosis vulgaris and other disorders of keratinization is discussed. In both cases, histopathology revealed a close relation between the keratotic plug and the sweat glands. The role of genetic factors and manual activity in the pathogenesis is discussed. Treatment with oral etretinate resulted in a good improvement in the first patient, but prolonged low-dose maintenance therapy was required to prevent recurrence.
authors.affiliation: Department of Dermatology, Hospital de Figueres, Figueres, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Just
authors.forename: M
authors.initials: M
authors.lastname: Ribera
authors.forename: I
authors.initials: I
authors.lastname: Bielsa
authors.forename: A
authors.initials: A
authors.lastname: Calatrava
authors.forename: C
authors.initials: C
authors.lastname: Ferrándiz
mesh_terms: D000328:Adult; D006229:Hand Dermatoses / Q000150:complications* / Q000473:pathology; D006801:Humans; D016112:Ichthyosis Vulgaris / Q000150:complications* / Q000473:pathology; D007642:Keratosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male; D010375:Pedigree