title: In vitro activities of SCH27899 alone and in combination with 17 other antimicrobial agents.
abstract: SCH27899, an everninomicin antibiotic, was tested for its in vitro activity against 718 bacterial isolates representing 27 species. The Enterobacteriaceae and nonenteric gram-negative bacilli were resistant to > or = 8.0 microg/ml, but all others were inhibited by < or = 1.0 microg/ml. When tested in combination with 17 other antimicrobial agents against 110 strains, SCH27899 demonstrated no significant antagonism or synergy. Consequently, combination therapy is not contraindicated.
authors.affiliation: Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA. cmi@hevanet.com
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C001202:evernimicin