title: A comparative study of Embelia schiperi and Embelia keniensis on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.
abstract: Intraperitoneal administration of the methanol extract of Embelia schiperi (ES) to normal mice caused a significant decrease in blood glucose (p < 0.01) and a significant increase in triglycerides 4 hours after administration at 100 mg/kg (p < 0.01). The toluene fraction of Embelia keniensis methanol extract (TS) showed hypoglycemic and lipid lowering activity 7 hours after intraperitoneal administration at 100 mg/kg. In addition, TS (100 mg/kg) administration significantly decreased blood glucose in epinephrine-induced hyperglycemic mice (p < 0.01). Moreover, ES tended to increase while TS tended to decrease the blood triglycerides in epinephrine-induced hyperglycemic mice. On the other hand, no changes in blood cholesterol were observed after the administration of ES or TS in normal and epinephrine-induced hyperglycemic mice. We found that two species from Embelia, ES and TS, have different activities on blood glucose and triglycerides in normal and epinephrine-induced hyperglycemic mice.
authors.affiliation: Kobe Pharmaceutical University, Hyogo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Tachibana
authors.forename: Y
authors.initials: Y
authors.lastname: Ohnishi
authors.forename: S G
authors.initials: SG
authors.lastname: Mathenge
authors.forename: R
authors.initials: R
authors.lastname: Albert
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004837:Epinephrine; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D010946:Plants, Medicinal; D013566:Sympathomimetics; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D010936:Plant Extracts; D013566:Sympathomimetics; D014280:Triglycerides; D002784:Cholesterol; D004837:Epinephrine