title: Absence of glutamic acid decarboxylase antibodies in childhood epilepsies.
abstract: Glutamic acid decarboxylase antibodies are present in some patients with therapy-resistant epilepsy. The authors measured glutamic acid decarboxylase antibodies in an unselected population of 114 children with different types of epilepsy. Three children with temporal lobe epilepsy and six children with various other types of epilepsy had intractable epilepsy. None of the children tested positive for glutamic acid decarboxylase antibodies. The study suggests that glutamic acid decarboxylase antibody testing cannot be recommended in unselected cases of childhood epilepsy.
authors.affiliation: Department of Pediatrics, University of Oulu, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Rantala
authors.forename: P
authors.initials: P
authors.lastname: Kulmala
authors.forename: K
authors.initials: K
authors.lastname: Savola
authors.forename: M
authors.initials: M
authors.lastname: Knip
mesh_terms: D000906:Antibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000175:diagnosis / Q000201:enzymology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male
chemical_list: D000906:Antibodies; D015415:Biomarkers; D005968:Glutamate Decarboxylase