Role of S-100beta as potential autoantigen in an autoimmune disease of the inner ear.
In Lewis rats, adoptive transfer of T cells specific for the calcium-binding protein S-100beta mediates experimental autoimmune encephalomyelitis, but surprisingly also induced a marked labyrinthitis associated with impairment of hearing. This suggests that transfer of S-100beta-specific T cells into susceptible animals could be a novel model to study autoimmunity of inner ear diseases. The investigation demonstrated in detail an inner ear involving, central nervous system (CNS)-specific autoimmune disease in order to identify a putatively shared autoantigen(s) in these pathologies. In fact, the model will be a useful tool to investigate in detail, the pathological mechanisms of the human inner ear disease associated with Vogt-Koyanagi-Harada disease.
Gloddek
B
B
Department of Otolaryngology/Head and Neck Surgery, Klinicum rechts der Isar der, Technical University München, Munich, Germany. b.gloddek@lrz.tu-muenchen.de
Lassmann
S
S
Gloddek
J
J
Arnold
W
W
D000818:Animals; D001324:Autoantigens / Q000502:physiology*; D001327:Autoimmune Diseases / Q000209:etiology*; D006320:Hearing Tests; D006801:Humans; D007150:Immunohistochemistry; D007759:Labyrinth Diseases / Q000209:etiology*; D008213:Lymphocyte Activation; D051381:Rats; D011917:Rats, Inbred Lew; D009418:S100 Proteins / Q000032:analysis / Q000502:physiology*; D014607:Uveomeningoencephalitic Syndrome / Q000209:etiology*
D001324:Autoantigens; D009418:S100 Proteins