Intracerebroventricular leptin inhibits gastric emptying of a solid nutrient meal in rats.
The effects of leptin injected intracerebroventricularly (i.c.v.) or i.p. on food intake and gastric emptying of a solid nutrient meal were studied in fasted Long-Evan rats. Leptin (3 microg, i.c.v.) reduced the 5 h cumulative food intake by 39% and gastric transit by 50% while i.p. leptin (300 microg) resulted in a 35% decrease in food intake and no change in gastric transit after 5 h. Lower i.p. doses of leptin (30 or 3 microg) did not alter food intake. These results show that central, unlike peripheral, injection of leptin inhibits gastric transit of an ingested meal; such a central action of leptin may contribute to the greater potency of i.c.v. than i.p. leptin to suppress food intake.
Martínez
V
V
CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles, CA 90073, USA.
Barrachina
M D
MD
Wang
L
L
Taché
Y
Y
D000818:Animals; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects* / Q000502:physiology; D007276:Injections, Intraventricular; D020738:Leptin / Q000008:administration & dosage* / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D013997:Time Factors
D020738:Leptin