Meta-analysis by combining p-values: simulated linkage studies.
Meta-analysis has been little explored to make an overall assessment of linkage from different studies. In practice, it is likely that published linkage studies will only report p-values. We compared the performance of the widely used Fisher method for combining p-values with that of pooling raw data. More loci were consistently found by pooling raw data. In the absence of further information, combining p-values can provide an overall, but limited, assessment of different linkage studies. However, meta-analysis would be better viewed as a preliminary step toward the goal of analyzing the pooled raw data.
Guerra
R
R
Department of Statistical Science, Southern Methodist University, Dallas, TX 75275, USA.
Etzel
C J
CJ
Goldstein
D R
DR
Sain
S R
SR
D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D015999:Multivariate Analysis
D005819:Genetic Markers