title: Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.
abstract: At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
authors.affiliation: Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Puglielli
authors.forename: J L
authors.initials: JL
authors.lastname: Browning
authors.forename: A W
authors.initials: AW
authors.lastname: Brewer
authors.forename: R D
authors.initials: RD
authors.lastname: Schreiber
authors.forename: W J
authors.initials: WJ
authors.lastname: Shieh
authors.forename: J D
authors.initials: JD
authors.lastname: Altman
authors.forename: M B
authors.initials: MB
authors.lastname: Oldstone
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: R
authors.initials: R
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008216:Lymphocytic Choriomeningitis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D053259:Lymphotoxin beta Receptor; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors*; D012131:Respiratory Insufficiency / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012772:Shock, Septic / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; C505697:LTBR protein, human; C505699:Ltbr protein, mouse; D053259:Lymphotoxin beta Receptor; D018124:Receptors, Tumor Necrosis Factor