Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus.
OBJECTIVE
To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.


METHODS
Seventeen mechanically ventilated preterm infants (<33 weeks' gestation) with PDA received either 0.2 mg/kg indomethacin (n = 8) or 10 mg/kg ibuprofen (n = 9), infused over 15 minutes. Mesenteric and renal blood flow velocity were measured by using Doppler ultrasonography.


RESULTS
Indomethacin caused a significant reduction in mesenteric and renal blood flow velocity 30 minutes after drug administration; mesenteric and renal blood flow velocity did not return to the pretreatment values by 120 minutes. Ibuprofen did not alter blood flow 30 minutes after treatment, and blood flow increased 120 minutes after treatment. Mesenteric and renal blood flow velocity changes were significantly different between the 2 treatment groups.


CONCLUSIONS
Compared with indomethacin, ibuprofen did not significantly reduce mesenteric and renal blood flow velocity.
Pezzati
M
M
Department of Pediatrics, Division of Neonatology, University of Firenze School of Medicine, Firenze, Italy.
Vangi
V
V
Biagiotti
R
R
Bertini
G
G
Cianciulli
D
D
Rubaltelli
F F
FF
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000503:physiopathology*; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D008643:Mesentery / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen