Orelox (cefodoxime) in typhoid fever.
OBJECTIVE
To study the efficacy of Orelox (Cefodoxime) in Typhoid fever in children.


METHODS
Open, non-comparative, multicentre study carried out in GP settings in various cities of Pakistan.


METHODS
Children aged 1-15 years were included in the study. Positive Widal test was the only diagnostic inclusion criteria.


RESULTS
Four centers participated in the study. Of the total 77 patients (51 males and 26 females), 61 (79%) cured, 5 (7%) improved (less severe signs and symptoms) and 11 (14%) failures.


CONCLUSIONS
Treatment of typhoid fever in this study showed 86% efficacy in producing clinical responses suggesting that this drug can be effectively and safely used in the treatment of typhoid fever in children.
Dhanjee
A
A
Dhanjee Clinic, Clifton, Karachi.
Sheikh
M A
MA
Yaqub
M
M
Alam
S E
SE
D000293:Adolescent; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D010154:Pakistan; D011355:Prodrugs / Q000627:therapeutic use*; D012485:Salmonella typhi; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000188:drug therapy*
D002511:Cephalosporins; D011355:Prodrugs