title: Preliminary study on HA coating percutaneously implanted in bone.
abstract: A comparative investigation on the possibility of hydroxyapatite (HA) coating and pure Ti column to form biological sealing with skin tissue was completed in this study. HA coating and pure Ti column were percutaneously implanted in the tibia of rabbits. Compared with titanium (Ti) implant, HA coating forms epithelial sealing with skin tissue at 6 weeks postoperatively, while the Ti implant may loosen from the implanted site and be lost. The Ti column loosing rate at this time was 50%. However, once the Ti implant becomes fixed with the bone tissue, it can form epithelial sealing with skin tissue just like the HA coating, at 8 weeks postoperatively. At 8 weeks postoperatively, the epithelial sealing is not destroyed in spite of the fact that the HA coating is biodegraded. Our results show that the HA coating can become fixed with the bone faster than the Ti, which is beneficial for epithelial sealing formation. The main role of HA coating for epithelial sealing is beneficial for sealing at the initial period after it is implanted.
authors.affiliation: Institute of Materials Science and Technology, Sichuan University, Chengdu, China. nic7500@scu.edu.con
authors.forename: B C
authors.initials: BC
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Weng
authors.forename: X D
authors.initials: XD
authors.lastname: Li
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Yang
authors.forename: J M
authors.initials: JM
authors.lastname: Feng
authors.forename: J Y
authors.initials: JY
authors.lastname: Chen
authors.forename: X D
authors.initials: XD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001186:Artificial Limbs; D001842:Bone and Bones / Q000601:surgery*; D020099:Coated Materials, Biocompatible / Q000032:analysis*; D062109:Dermatologic Surgical Procedures; D004195:Disease Models, Animal; D017886:Durapatite / Q000032:analysis*; D004848:Epithelium / Q000473:pathology; D007866:Leg; D016348:Osseointegration; D010406:Penicillins / Q000008:administration & dosage; D011292:Premedication; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods; D016459:Prosthesis-Related Infections / Q000517:prevention & control; D011817:Rabbits; D012680:Sensitivity and Specificity; D012867:Skin / Q000473:pathology; D014025:Titanium; D014945:Wound Healing
chemical_list: D020099:Coated Materials, Biocompatible; D010406:Penicillins; D017886:Durapatite; D014025:Titanium