The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay.
We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.
Hartmann
K A
KA
Department of Radiation Oncology, University of Dusseldorf, D-40225 Dusseldorf, Germany.
Carl
U M
UM
Sminia
P
P
Lammering
G
G
Becker
K A
KA
Schmitt
G
G
D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D002455:Cell Division; D007511:Ischemia / Q000473:pathology*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D012208:Rhabdomyosarcoma / Q000098:blood supply* / Q000473:pathology
D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen