Selective retention of n-3 and n-6 fatty acids in human milk lipids in the face of increasing proportions of medium chain-length (C10-14) fatty acids.
This paper reports the results of our analysis of the impact high levels of de novo fatty acids have on the proportions of essential and non-essential fatty acids in human milk lipids. The data for seven fatty acids (linoleic, alpha-linolenic, arachidonic (AA), docosahexaenoic (DHA), palmitic, stearic and oleic) were derived from several studies conducted in Nigeria. The proportion by weight of each of these fatty acids was plotted versus the proportion of C10-14 fatty acids. As the proportion of C10-14 fatty acids increased from 15 to 65%, there was not a proportional decrease in the percentages of all seven fatty acids, but, instead, preferential incorporation of the essential fatty acids, AA and DHA into the triacylglycerol component of the milk. At the same time, the proportions of stearic and oleic acid declined by 69% and 86%, respectively. However, the proportions of linoleic acid, palmitic acid, DHA, AA and alpha-linolenic acid, in milk lipids decreased by only 44%, 40%, 39%, 28% and 2.3%, respectively. These observations indicate that as the contribution of C10-14 fatty acids increases, essential fatty acids are preferentially incorporated into milk triacylglycerols at the expense of oleic acid and stearic acid.
Schmeits
B L
BL
Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque 87131, USA.
VanderJagt
D J
DJ
Okolo
S N
SN
Huang
Y S
YS
Glew
R H
RH
D000293:Adolescent; D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage; D019422:Dietary Sucrose / Q000008:administration & dosage; D005227:Fatty Acids / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D005228:Fatty Acids, Essential / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D009549:Nigeria; D014280:Triglycerides / Q000737:chemistry / Q000378:metabolism
D004041:Dietary Fats; D019422:Dietary Sucrose; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D008055:Lipids; D014280:Triglycerides