Effect of propolis extract on D-galactosamine-induced hepatic injury in rats.
The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose-dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.
Sugimoto
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Tarumi
T
T
Kaneko
Y
Y
Isayama
S
S
Kawai
N
N
Sugimoto
H
H
Yamada
H
H
Kamei
C
C
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D003911:Dextrans / Q000494:pharmacology; D005688:Galactosamine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008297:Male; D011429:Propolis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans; D005688:Galactosamine; D011429:Propolis; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase