title: The impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy.
abstract: BACKGROUND
  A study was needed to determine the effect of primary tumor volume on local control of oropharyngeal carcinoma treated with radiation therapy, with or without induction chemotherapy.
  
  
  METHODS
  Between July 1983 and April 1995, 114 patients with T2-T4 squamous cell carcinoma of the oropharynx were treated for cure with radiation therapy, with or without induction chemotherapy, and had a pretreatment CT scan available for retrospective review. All scans were reviewed by a single radiologist (A. A. M.) to determine the tumor volume of the primary lesion. Volume was measured with a computer digitizer for each CT slice showing the primary lesion.
  
  
  RESULTS
  A large variation in tumor volume within a given T stage was found. Multivariate analysis demonstrated T stage to be the most significant factor affecting local control. Tumor volume marginally influenced local control (p =.10).
  
  
  CONCLUSIONS
  Primary tumor volume varies significantly within a given T stage and has a marginal impact on the likelihood of local control after radiotherapy.
authors.affiliation: Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL 32610-0385, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Nathu
authors.forename: A A
authors.initials: AA
authors.lastname: Mancuso
authors.forename: T C
authors.initials: TC
authors.lastname: Zhu
authors.forename: W M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome