title: Analgesic activity of thioureido derivatives of arylsemicarbazones.
abstract: The synthesis of a series of novel arylsemicarbazones derived from 4-aminoacetophenone and their evaluation for analgesic activity are described. The p-chloro-substituted derivatives (12-15) are extremely potent compounds as compared to standard drugs currently being used.
authors.affiliation: Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India.
authors.forename: V
authors.initials: V
authors.lastname: Mishra
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: P N
authors.initials: PN
authors.lastname: Singh
authors.forename: D C
authors.initials: DC
authors.lastname: Rupainwar
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D008297:Male; D010147:Pain Measurement / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012664:Semicarbazones / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D012664:Semicarbazones; D013890:Thiourea