[Effect of thymus polypeptide fractions on the development of rat thymus and spleen in organ culture].
Peptides of the thymus--vilon, thymogen and thymalin, alone or in combination with concanavalin A, were used to investigate their effect on organotypic culture of thymus and spleen explants from 1- and 21-day old rats. Vilon, thymogen and thymalin in concentrations of 2 and 10 ng/ml and 5 ng/ml, resp., exerted stimulating effects in thymus and spleen tissue cultures from 21-day old rats as compared to the control explants. Vilon and thymogen showed inhibiting effect in the thymus tissue cultures from 1-day old rats as compared to the control explants. However, the peptides together with concanavalin A in concentration of 10 mkg/ml resulted in decreasing the action of concanavalin A alone. The polypeptide fractions of thymus and their synthetic analogs play different roles in the regulation of thymus and spleen development in rats of different age.
Chalisova
N I
NI
Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Khavinson
V Kh
VKh
Penniiaĭnen
V A
VA
Grigor'ev
E I
EI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004151:Dipeptides; D009924:Organ Culture Techniques; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism; D013951:Thymus Hormones / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; D013951:Thymus Hormones; D003208:Concanavalin A; C060736:thymogen; C032805:thymalin
Vliianie polipeptidnykh fraktsiĭ timusa na razvitie organotipicheskoĭkul'tury vilochkovoĭ zhelezy i selezenki krysy.