title: Cell proliferation and apoptosis.
abstract: Cell proliferation and cell death are essential yet opposing cellular processes. Crosstalk between these processes promotes a balance between proliferation and death, and it limits the growth and survival of cells with oncogenic mutations. New insights into the mechanisms by which strong signals to proliferate and activation of cyclin-dependent kinases promote apoptosis have recently been published, and a novel cell cycle regulated caspase inhibitor, Survivin, has been described.
authors.affiliation: Department of Neurology, University of California in Los Angeles (UCLA) Medical Center, C-128 RNRC, Los Angeles, CA 90095, USA. mingfly@itsa.ucsf.edu.
authors.forename: M
authors.initials: M
authors.lastname: Guo
authors.forename: B A
authors.initials: BA
authors.lastname: Hay
mesh_terms: D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins; D002455:Cell Division; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D006133:Growth Substances / Q000502:physiology; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D009857:Oncogenes / Q000502:physiology; D011506:Proteins / Q000378:metabolism / Q000502:physiology; D016160:Retinoblastoma Protein / Q000502:physiology; D056465:Retinoblastoma-Binding Protein 1; D015398:Signal Transduction; D000077022:Survivin; D014157:Transcription Factors / Q000502:physiology
chemical_list: C107489:BIRC5 protein, human; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D006133:Growth Substances; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D000077022:Survivin; D014157:Transcription Factors; D018844:Cyclin-Dependent Kinases