[Acute hepatitis in the course of cyclosporine therapy of Crohn's disease].
BACKGROUND
Cyclosporin is used for the treatment of corticosteroid-resistant inflammatory bowel disease. Secondary liver disease is a risk.


METHODS
Acute hepatitis with predominant major transaminase elevation occurred in a patient treated with cyclosporin for corticosteroid-resistant Crohnś disease. No viral, alcoholic, autoimmune or metabolic cause could be incriminated. Complete cure was achieved after withdrawal of cyclosporin.


CONCLUSIONS
Only one case of cholestatic hepatitis has been reported in chronic inflammatory bowel disease. Cyclosporin was the probable cause in our case as other causes of acute hepatitis were ruled out and withdrawal led to cure. Cyclosporin can induce abnormal liver tests in 25% of cases. If reducing dose does not lead to improvement, it may be necessary to discontinue cyclosporin. Regular liver tests would thus be required for patients given cyclosporin for chronic inflammatory bowel disease.
Ngo
M D
MD
Service d'Hépato-Gastroentérologie, Centre Hospitalier Intercommunal de Créteil.
Hagège
H
H
Rosa
I
I
Cartier
V A
VA
Lons
T
T
Gordin
J
J
Chousterman
M
M
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016896:Treatment Outcome
D016572:Cyclosporine
Hépatite aiguë au cours du traitement d'une maladie de Crohn par ciclosporine.