title: The continuing challenge of Fournier's gangrene in the 1990s.
abstract: Fournier's disease is a potentially fatal acute, gangrenous infection of the scrotum, penis, or perineum associated with a synergistic bacterial infection of the subcutaneous fat and superficial fascia. Thrombosis of small subcutaneous arterioles with resultant ischemia contributes to the rapid extension of the infection. During a 12-year period, the clinical and operative records of 14 patients with Fournier's gangrene were analyzed. All patients were treated with broad spectrum antibiotics and serial surgical debridements. Nine patients had polymicrobial isolates from the initial wound culture; two patients had Group A Streptococcus species as the sole isolate. The etiology of the infection was identified in 12 patients. Five patients died for an overall mortality of 38 per cent. The mean age of survivors was 51 years compared with 75 years for nonsurvivors (P<0.05). The last six patients in this series survived. The mean hospital stay was 29 days. Four patients (31%) had a prior history of diabetes; however, 11 patients (85%) had elevated serum glucose levels (>120 mg/dL) on admission. All patients were hypoalbuminemic on admission. Survivors had an average serum creatinine on admission of 1.28 mg/dL compared with 3.1 mg/dL for nonsurvivors. Although supportive care is required in these patients, the mainstay for treatment of Fournier's gangrene entails an aggressive approach with frequent and extensive soft tissue debridements to control the invasive nature of the infection with delayed wound coverage once the infection has been controlled. Elderly patients with evidence of renal dysfunction on admission have a poor prognosis despite aggressive therapy.
authors.affiliation: Department of Surgery, University of Louisville School of Medicine, Kentucky 40292, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Olsofka
authors.forename: E H
authors.initials: EH
authors.lastname: Carrillo
authors.forename: D A
authors.initials: DA
authors.lastname: Spain
authors.forename: H C
authors.initials: HC
authors.lastname: Polk
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002423:Cause of Death; D003404:Creatinine / Q000097:blood; D003646:Debridement; D048909:Diabetes Complications; D018934:Fournier Gangrene / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000175:diagnosis; D010502:Perineum / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012611:Scrotum / Q000473:pathology; D012709:Serum Albumin / Q000032:analysis; D013290:Streptococcal Infections / Q000175:diagnosis; D013297:Streptococcus pyogenes; D015996:Survival Rate; D013927:Thrombosis / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D012709:Serum Albumin; D003404:Creatinine