title: Altered cardiac tissue and plasma kininogen levels in hypertensive and diabetic rats.
abstract: The present investigation was aimed at evaluating the cardiac and total plasma kininogen levels, as well as LVWT in hypertensive and diabetic rats. STZ-induced diabetes produced a significant (P < 0.001) rise in mean arterial blood pressure (BP). The LVWT increased (P < 0.001) in SHR with and without diabetes) and diabetic WKYR. The cardiac tissue, as well as total plasma kininogen levels fell significantly (P < 0.001) in diabetic WKYR and SHR with and without diabetes compared to the control WKYR. These findings suggest that reduced kininogen levels may indicate a deficiency in kinin generation in the heart and in the peripheral circulation in diabetic and hypertensive rats. This effect may contribute to the development of LVH.
authors.affiliation: Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia. jnarain@usm.my
authors.forename: J N
authors.initials: JN
authors.lastname: Sharma
authors.forename: U
authors.initials: U
authors.lastname: Kesavarao
authors.forename: A P
authors.initials: AP
authors.lastname: Yusof
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007704:Kininogens / Q000032:analysis* / Q000097:blood; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D007704:Kininogens; D013311:Streptozocin