Haplotype analysis in the Collaborative Study on the Genetics of Alcoholism data: double recombinants.
The presence of close double recombinants in genotyping data may help identify genotyping errors. Alternatively, putative double recombinants may be associated with genetic mechanisms that may be related to disease. Phase-known apparent double recombination events were identified in the Collaborative Study on the Genetics of Alcoholism data, and compared to the sex-specific genetic map at each region. A number of double recombinants occurred within a short genetic distance. Also, in some families multiple double recombinants were observed flanking the same genetic marker, both suggesting possible genotyping error. An excess of paternal double recombinants was identified, which is consistent with reports of sex-specific differential meiotic interference.
Petronis
A
A
Neurogenetics Section, University of Toronto, Ontario, Canada.
Kennedy
J L
JL
Paterson
A D
AD
D000437:Alcoholism / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005820:Genetic Testing; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011995:Recombination, Genetic; D012737:Sex Factors