Meta-analysis of genetic linkage to quantitative trait loci with study-specific covariates: a mixed-effects model.
A method of meta-analysis was used to combine summary linkage information from four hypothetical study groups simulated in GAW11 Problem 2 with no knowledge of the answer. Five replication studies were selected from each group, and a pool of 20 primary studies was used for combining. Using a mixed-effects model with the among-study variation as random effects, we pooled results from all the 20 studies and detected strong linkage signals on chromosome 5 at D5G38 and on chromosome 3 near D3G45. We also found suggestive signals on chromosome 1 near D1G9, and possible interaction of D1G24 with the selection for the severe form of the disease.
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Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
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D004777:Environment; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D019655:Quantitative Trait, Heritable; D012984:Software
D005819:Genetic Markers