Novel intronic variants of MICB (MHC class I chain-related gene B).
We report an eight-nucleotide duplication in intron 4 of the MICB allele 01021, which was found in samples from different ethnic backgrounds and in association with several HLA-B alleles. We suggest that this new MICB allele is evolutionarily older than HLA-B alleles.
Fischer
G
G
Anthony Nolan Research Institute, The Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.
Argüello
J R
JR
Pérez-Rodríguez
M
M
Cox
S T
ST
McWhinnie
A
A
Marsh
S G
SG
Madrigal
J A
JA
D000483:Alleles; D001402:B-Lymphocytes / Q000737:chemistry; D001483:Base Sequence; D002460:Cell Line; D005006:Ethnicity / Q000235:genetics; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D015235:HLA-B Antigens / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D015235:HLA-B Antigens; D015395:Histocompatibility Antigens Class I; C098080:MICB antigen