title: Diagnosis of neonatal hemochromatosis with MR imaging and duplex Doppler sonography.
abstract: Neonatal hemochromatosis is a rare congenital disorder which affects both fetuses and newborns. It is characterized by hepatocellular failure, often appearing on the first day of life in the form of coagulopathy, hypoalbuminemia, hypoglycemia, and jaundice. Most of the affected infants die early in life, and definitive diagnosis has often been made only by post-mortem evaluation. With the help of MRI, plus increasing awareness of the disorder, diagnosis is now often made early, even in utero. Duplex Doppler sonography does not provide information on siderosis but shows abnormalities in the liver or blood-flow patterns associated with liver disease.
authors.affiliation: Department of Radiology, G. Gaslini Children's Research Hospital, Largo G. Gaslini, 5, I-16147 Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Oddone
authors.forename: C
authors.initials: C
authors.lastname: Bellini
authors.forename: W
authors.initials: W
authors.lastname: Bonacci
authors.forename: M
authors.initials: M
authors.lastname: Bartocci
authors.forename: P
authors.initials: P
authors.lastname: Toma
authors.forename: G
authors.initials: G
authors.lastname: Serra
mesh_terms: D001706:Biopsy; D001783:Blood Flow Velocity; D003937:Diagnosis, Differential; D005260:Female; D006432:Hemochromatosis / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D008102:Liver Circulation; D008107:Liver Diseases / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D018616:Ultrasonography, Doppler, Duplex