title: The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000.
abstract: SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases. Recent developments of the database include format and content enhancements, cross-references to additional databases, new documentation files and improvements to TrEMBL, a computer-annotated supplement to SWISS-PROT. TrEMBL consists of entries in SWISS-PROT-like format derived from the translation of all coding sequences (CDSs) in the EMBL Nucleotide Sequence Database, except the CDSs already included in SWISS-PROT. We also describe the Human Proteomics Initiative (HPI), a major project to annotate all known human sequences according to the quality standards of SWISS-PROT. SWISS-PROT is available at: http://www.expasy.ch/sprot/ and http://www.ebi.ac.uk/swissprot/
authors.affiliation: Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. amos.bairoch@medecine.unige.ch
authors.forename: A
authors.initials: A
authors.lastname: Bairoch
authors.forename: R
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D000818:Animals; D016208:Databases, Factual; D016678:Genome; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D018511:Systems Integration
chemical_list: D011506:Proteins