Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.
Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L. In this study, we evaluated the anti-inflammatory activity of punicalagin and punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of punicalin. The data showed that both punicalagin and punicalin exert anti-inflammatory activity, but treatment with larger doses of punicalin may induce some cell damages.
Lin
C C
CC
Graduate Institute of Natural Products, Kaohsiung Medical College, Taiwan.
Hsu
Y F
YF
Lin
T C
TC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002351:Carrageenan; D047348:Hydrolyzable Tannins; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007700:Kinetics; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D013634:Tannins / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D047348:Hydrolyzable Tannins; D013634:Tannins; C115642:punicalagin; C115643:punicalin; D002351:Carrageenan; D007213:Indomethacin