[In Process Citation]
To prevent disturbances of blood gas-transport function in hemorrhagic shock, we used cross-over protective effect of adaptation to short-term immobilisation stress. Adaptation of rats to stress was associated with a rise in baseline arterial pressure, hematocrit, oxygen capacity and concentration of buffer bases in arterial blood, pH in venous blood; fall in PO2, PCO2, P50. Stress-adapted rats appeared more resistant to blood loss. Gas transport 1 hour after hemorrhage was better than in non-adapted animals. In hemorrhagic shock, the adapted animals demonstrated more active compensatory reactions in low hypoxic damage to the tissues. 2.5-h survival after start of bleeding in control animals made up 35%, in the group of adapted animals--67%. Thus, adaptation to short-term immobilization stress is a non-pharmacological method to prevent hemorrhagic shock.