title: Antibody prevalence and specificity to group C rotavirus in Swedish sera.
abstract: Of 160 sera collected from different age groups throughout Sweden, 38% were found to be antibody positive for group C rotavirus. The highest antibody prevalence rate was found in individuals aged 11-30 years (45%). An immunoprecipitation assay revealed that the antibodies were directed against VP2, VP4, VP6, VP7, and NSP2, with VP6 being the most immunogenic protein. Neutralising antibodies against a cultivable porcine group C rotavirus (strain AmC-1/Cowden) were detected in 16/19 individuals at titres from 160 to 5,120. The results indicate that group C rotavirus infections are relatively common in older Swedish children and adults but appear to be less common in children younger than 5 years of age. It is concluded that porcine and human group C rotaviruses share epitopes critical for stimulation of neutralising antibodies.
authors.affiliation: Department of Virology, Swedish Institute for Infectious Disease Control, Karolinska Institute, Solna, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Nilsson
authors.forename: G
authors.initials: G
authors.lastname: Sigstam
authors.forename: L
authors.initials: L
authors.lastname: Svensson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D015531:Radioimmunoprecipitation Assay; D012401:Rotavirus / Q000254:growth & development / Q000276:immunology*; D012400:Rotavirus Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D016036:Seroepidemiologic Studies; D013548:Sweden / Q000453:epidemiology; D013552:Swine; D013737:Testis / Q000166:cytology / Q000821:virology
chemical_list: D000914:Antibodies, Viral