title: Splenic involvement by blastic mantle cell lymphoma (large cell/anaplastic variant) mimicking splenic marginal zone lymphoma.
abstract: The most cases of splenic marginal zone lymphoma (SMZL) seem to respond favorably to splenectomy. The diagnosis of this lymphoma is mainly based on the recognition of a micronodular pattern of splenic involvement with marginal zone differentiation. However, it is possible to find so-called "marginal zone differentiation" in splenic involvement by other small B-cell lymphomas, particularly mantle cell lymphoma (MCL) and follicular lymphoma. We report a case of blastic MCL, large cell/anaplastic variant with a high level of clinical aggressiveness, showing biphasic cytology and a micronodular pattern which resembles SMZL. A single biopsy corresponding to this case shows two phases of tumoral progression in a MCL, a rare finding in MCL. In conclusion, the differential diagnosis of SMZL must take the possibility of a blastic MCL with biphasic cytology into account, as the case here.
authors.affiliation: Department of Pathology, Virgen de la Salud Hospital, Toledo, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Mollejo
authors.forename: E
authors.initials: E
authors.lastname: Lloret
authors.forename: J
authors.initials: J
authors.lastname: Solares
authors.forename: J M
authors.initials: JM
authors.lastname: Bergua
authors.forename: M
authors.initials: M
authors.lastname: Mateo
authors.forename: M A
authors.initials: MA
authors.lastname: Piris
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D013154:Spleen / Q000473:pathology*; D013160:Splenic Neoplasms
chemical_list: D015703:Antigens, CD