The effects of high-frequency microstimulation of the cortex on interhemisphere synchronization in the rat motor cortex.
Studies were carried out on long-term changes in the synchronization of neuronal activity in networks including callosal cells of the opposite hemispheres evoked by high-frequency microstimulation in the motor cortex of anesthetized rats. The level of synchronization was assessed in terms of the amplitude and width of peaks located symmetrically on cross-correlograms relative to the coordinate origin. Tetanization predominantly decreased synchronization in a group of initially background-active neurons, while there was a significant number of synchronously firing neurons in a group of cells which became activated. "Super-narrow" peaks appeared in interhemisphere interactions. There was a correlation between the type of modification of "narrow" (<20 msec) and "intermediate" (30-80 msec) peaks and changes in the efficiencies of mono- and polysynaptic connections.
Bogdanova
O G
OG
Neurophysiology Laboratory, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Sil'kis
I G
IG
D000818:Animals; D003337:Corpus Callosum / Q000166:cytology / Q000502:physiology; D003344:Cortical Synchronization; D004558:Electric Stimulation; D007839:Functional Laterality / Q000502:physiology*; D008297:Male; D008839:Microelectrodes; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D051381:Rats