The First Catalytic Asymmetric Nitro-Mannich-Type Reaction Promoted by a New Heterobimetallic Complex.
The best ratio is 1:1:3 for the components Yb, K, and binaphthol in the new heterobimetallic complex, which efficiently catalyzes an asymmetric nitro-Mannich-type reaction. The desired nitro-Mannich products 2 are obtained with up to 91 % ee starting from N-phosphinoyl imines 1.
Yamada
Ki
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
Harwood
SJ
Gröger
H
Shibasaki
M