Asymmetric Total Synthesis of Fluvirucinine A(1).
Diastereoselective vinyl addition to an amide carbonyl group and amide enolate induced aza-Claisen rearrangement are the key steps in the first asymmetric total synthesis of fluvirucinine A(1) (1), the aglycon of fluvirucin A(1). Fluvirucins are a class of macrolactam antibiotics produced by actinomycete strains that show promising biological properties.
Suh
YG
College of Pharmacy, Seoul National University, San 56-1, Shinrim-Dong, Kwanak-Gu, Seoul 151-742 (Korea).
Kim
SA
Jung
JK
Shin
DY
Min
KH
Koo
BA
Kim
HS