title: [Evaluation of severity and clinical course of acute mucosal reaction during postop radiotherapy of laryngeal cancer].
abstract: In the group of 110 epiglottic and glottic cancer patients treated with postoperative radiotherapy, relationships between the severity of acute mucosal reaction and time of treatment for different types of surgery and for different intervals between surgery and postoperative radiotherapy were analysed. The dependence between the total dose and the radiation reaction was assigned. The maximal radiation reaction appeared in the fourth week of irradiation independently of operation type. The highest grade of reaction in the last week of irradiation appeared in the group after limited operations and the lowest one in the group after total laryngectomy. There was a statistically significant difference between distribution of acute radiation injury grade in a group after limited operation and a group after hemilaryngectomy compared by Wilcoxon matched pairs test. For the interval between operation and radiotherapy shorter than 6 weeks the highest reaction was in the fourth, for the interval 6 to 12 weeks in the third and for the interval longer than 22 weeks in the fifth week of irradiation. The highest reaction in the last irradiation week appeared in the first group, the lowest one in the second group. However, generally the time-interval between surgery and radiotherapy does not influence the severity of acute mucosal reaction (there was no statistically significant difference between reaction grade distribution compared by Wilcoxon matched pairs test). There was also no correlation between the total dose and intensity of radiation injury in last irradiation week. The interrelationships and other factors which could influence the obtained results were considered. The main final conclusions were formed: maximal intensity of mucous membrane radiation injury and the intensity in the last week of treatment depend on the character of previous operation (smaller operation--bigger postradiation reaction) and do not depend on total dose or on the interval between operation and beginning of radiotherapy.
authors.affiliation: Zakład Radioterapii, Instytutu im. M. Skłodowskiej-Curie, Oddział Gliwice.
authors.forename: L
authors.initials: L
authors.lastname: Miszczyk
authors.forename: W
authors.initials: W
authors.lastname: Przeorek
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000528:radiation effects / Q000601:surgery; D011182:Postoperative Care; D011183:Postoperative Complications / Q000175:diagnosis*; D011832:Radiation Injuries / Q000175:diagnosis*; D012189:Retrospective Studies; D016896:Treatment Outcome
vernacular_title: Ocena nasilenia i przebiegu ostrego odczynu popromiennego błony śluzowej w trakcie pooperacyjnej radioterapii raka krtani.