title: [Solitary fibrous tumor of the pleura with elevated high-molecular-weight insulin-like growth factor II and hypoglycemia].
abstract: Recurrent hypoglycemia occurred in a 58-year-old woman with a solitary fibrous tumor of the pleura and exhibiting CD34 immunopositivity. During episodes of hypoglycemia, serum high-molecular-weight insulin-like growth factor II (big IGF-II) was elevated. After removal of the tumor containing IGF-II, the hypoglycemia and serum big IGF-II disappeared. This was followed by an increase in normal IGF-II. We speculate that the primary cause of hypoglycemia in this patient was the presence of big IGF-II produced by the solitary fibrous tumor of the pleura. To our knowledge, the presence of this type of IGF-II in CD34+ solitary fibrous tumors of the pleura has not been described to date in the literature.
authors.affiliation: Division of Internal Medicine, Syuso Public Hospital, Ehime, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
authors.forename: N
authors.initials: N
authors.lastname: Hizuka
mesh_terms: D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000737:chemistry; D008654:Mesothelioma / Q000150:complications* / Q000378:metabolism; D008875:Middle Aged; D008970:Molecular Weight; D010997:Pleural Neoplasms / Q000150:complications* / Q000378:metabolism
chemical_list: D007335:Insulin-Like Growth Factor II