4-Hydroxynonenal as a second messenger of free radicals and growth modifying factor.
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and the regulation of cerebral blood flow determining secondary brain damage. Similarly, HNE was determined during ischemia in the brain blood vessels of rats exposed to ischemia/reperfusion injury of the brain. After reperfusion, HNE disappeared from the blood vessels but remained in neurones and in glial cells. Since HNE modulates cell proliferation and differentiation (including proto-oncogene expression), it is postulated that HNE might have prominent local and systemic effects that are not only harmful but beneficial, too, determining the outcome of various pathophysiological conditions based on oxidative stress.
Zarković
N
N
Rudjer Bosković Institute, Zagreb, Croatia.
Zarković
K
K
Schaur
R J
RJ
Stolc
S
S
Schlag
G
G
Redl
H
H
Waeg
G
G
Borović
S
S
Loncarić
I
I
Jurić
G
G
Hlavka
V
V
D000447:Aldehydes / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002543:Cerebral Hemorrhage / Q000150:complications / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry; D002546:Ischemic Attack, Transient / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology; D010215:Papio; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015290:Second Messenger Systems / Q000276:immunology / Q000502:physiology*; D018805:Sepsis / Q000378:metabolism; D012769:Shock / Q000150:complications / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D000447:Aldehydes; D000911:Antibodies, Monoclonal; D005609:Free Radicals; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos; C027576:4-hydroxy-2-nonenal; D013936:Thymidine