title: High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region.
abstract: Histone deacetylases have been described as crucial cofactors of mammalian transcriptional complexes. We have recently identified human histone deacetylase HDAC3 on chromosome 5q31 by fluorescence in situ hybridization (FISH) in a region commonly deleted in malignant myeloid disease. Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband.
authors.affiliation: Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA. Mahlknecht@em.uni-frankfurt.de
authors.forename: U
authors.initials: U
authors.lastname: Mahlknecht
authors.forename: R
authors.initials: R
authors.lastname: Bucala
authors.forename: D
authors.initials: D
authors.lastname: Hoelzer
authors.forename: E
authors.initials: E
authors.lastname: Verdin
mesh_terms: D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D000099186:Histone Deacetylase 3
chemical_list: D005819:Genetic Markers; D006655:Histone Deacetylases; D000099186:Histone Deacetylase 3