title: Bone mineral density and androgen levels in elderly males.
abstract: To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55-90 years) the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied. BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between body mass index (BMI) and BMD at the lumbar spine and femoral neck (P < 0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related factors must be associated with bone loss in elderly males.
authors.affiliation: Clínica de Na Sra de la Concepción, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rapado
authors.forename: F
authors.initials: F
authors.lastname: Hawkins
authors.forename: L
authors.initials: L
authors.lastname: Sobrinho
authors.forename: M
authors.initials: M
authors.lastname: Díaz-Curiel
authors.forename: A
authors.initials: A
authors.lastname: Galvao-Telles
authors.forename: S
authors.initials: S
authors.lastname: Arver
authors.forename: J
authors.initials: J
authors.lastname: Melo Gomes
authors.forename: N
authors.initials: N
authors.lastname: Mazer
authors.forename: J
authors.initials: J
authors.lastname: Garcia e Costa
authors.forename: C
authors.initials: C
authors.lastname: Horcajada
authors.forename: E
authors.initials: E
authors.lastname: López-Gavilanes
authors.forename: M
authors.initials: M
authors.lastname: Mascarenhas
authors.forename: K
authors.initials: K
authors.lastname: Papapietro
authors.forename: M B
authors.initials: MB
authors.lastname: López Alvarez
authors.forename: M C
authors.initials: MC
authors.lastname: Pereira
authors.forename: G
authors.initials: G
authors.lastname: Martinez
authors.forename: I
authors.initials: I
authors.lastname: Valverde
authors.forename: J J
authors.initials: JJ
authors.lastname: García
authors.forename: J J
authors.initials: JJ
authors.lastname: Carballal
authors.forename: I
authors.initials: I
authors.lastname: García
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*; D014809:Vitamin D-Binding Protein / Q000097:blood
chemical_list: D012738:Sex Hormone-Binding Globulin; D014809:Vitamin D-Binding Protein; D015675:Osteocalcin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone