title: Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis.
abstract: The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system. Recombinant Hu-IFN-alpha B/D significantly reduced the mortality in a mouse encephalitis model (about 30%, P = 0.021), whereas natural mouse interferon was inactive. Combination of acyclovir with Hu-IFN-alpha B/D had an additive effect.
authors.affiliation: Department of Pediatrics, University of Munich, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Wintergerst
authors.forename: J D
authors.initials: JD
authors.lastname: Gangemi
authors.forename: R J
authors.initials: RJ
authors.lastname: Whitley
authors.forename: S
authors.initials: S
authors.lastname: Chatterjee
authors.forename: E R
authors.initials: ER
authors.lastname: Kern
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D051379:Mice; D011994:Recombinant Proteins
chemical_list: D000998:Antiviral Agents; D007370:Interferon Type I; D011994:Recombinant Proteins; D000212:Acyclovir