Choroidal infiltrates simulating fundal changes of acute leukemia during hematological recovery following high-dose chemotherapy in acute myelomonocytic leukemia in remission.
A young female patient of 18 who was diagnosed to have acute myelomonocytic leukemia (AML M4) developed choroidal infiltrate and fundal changes suggestive of acute leukemia deposits while she was in remission and was recovering from chemotherapy induced myelosuppression. The choroidal infiltrates were associated with peripheral blood and CSF monocytosis. The choroidal lesion resolved on its own in 2 week's time, when the peripheral and CSF monocytosis subsided. Interestingly this patient had pseudo-Chediak Higashi inclusions in leukemic blasts with normal karyotype.
Ghosh
K
K
Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
Mitra
S
S
Hiwase
D
D
D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002555:Cerebrospinal Fluid / Q000166:cytology; D002829:Choroid / Q000473:pathology*; D003561:Cytarabine / Q000008:administration & dosage; D003594:Cytoplasmic Granules / Q000473:pathology; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy* / Q000473:pathology*; D007958:Leukocyte Count; D008942:Mitoxantrone / Q000008:administration & dosage; D009000:Monocytes / Q000473:pathology; D012074:Remission Induction
D000970:Antineoplastic Agents; D003561:Cytarabine; D008942:Mitoxantrone; D003630:Daunorubicin