title: Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly.
abstract: A 73-year-old man had fever, lymphadenopathy, granulocytopenia, thrombocytopenia, ascites, pleural effusion, liver injury, and an allergic-like skin rash. Autoantibodies, such as anti-nuclear antibody, were shown, and there were lactate dehydrogenase and alkaline phosphatase anomalies and platelet-associated IgG. His liver injury resembled that in autoimmune hepatitis. He was diagnosed with Epstein-Barr virus (EBV) infection associated with autoimmunization because of his clinical course, fluctuation of anti EBV antibodies and positive EBV genome in circulating lymphocytes and serum. This case suggests a close relationship between EBV infection and autoimmunization or autoimmune-like hepatitis.
authors.affiliation: Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: R
authors.initials: R
authors.lastname: Nagayama
authors.forename: S
authors.initials: S
authors.lastname: Hirama
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Takikawa
authors.forename: K
authors.initials: K
authors.lastname: Miyake
authors.forename: M
authors.initials: M
authors.lastname: Yamanaka
authors.forename: J
authors.initials: J
authors.lastname: Shiga
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase