title: Benign familial Degos disease worsening during immunosuppression.
abstract: We describe a 61-year-old woman with skin lesions consistent with those found in Degos disease, both in clinical and in histological appearance. She had had several of these lesions for many years, as had her mother, sister and niece. In 1991, she underwent cadaveric renal transplantation and was treated with immunosuppression: prednisolone, azathioprine and cyclosporin. At that time, she developed many more characteristic skin lesions, and these were slightly larger and more noticeable than those she had had previously. She and the other affected family members appear to fit into the more benign subgroup of Degos disease, and it seems that her immunosuppression aggravated her cutaneous disease.
authors.affiliation: Department of Dermatology, Oxford Radcliffe Hospitals, Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: Powell
authors.forename: C
authors.initials: C
authors.lastname: Bordea
authors.forename: F
authors.initials: F
authors.lastname: Wojnarowska
authors.forename: A M
authors.initials: AM
authors.lastname: Farrell
authors.forename: P J
authors.initials: PJ
authors.lastname: Morris
mesh_terms: D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008875:Middle Aged; D017444:Skin Diseases, Papulosquamous / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D013577:Syndrome