title: Chemically Modified Antisense Oligonucleotides-Recent Improvements of RNA Binding and Ribonuclease H Recruitment.
abstract: The incorporation of rationally designed sugar or nucleobase modifications into oligonucleotides gives remarkable improvements of the antisense activity. For example, the cytosine analogue 1 recognizes both the Watson-Crick and the Hoogsteen site of a guanine nucleotide 2, which dramatically enhances the RNA-binding affinity and selectivity.
authors.affiliation: Institut für Organische Chemie der Universität, Richard-Willstätter-Allee 2, D-76128 Karlsruhe (Germany).
authors.initials: O
authors.lastname: Seitz