Cochlear gene therapy: current perspectives.
Gene therapy has the potential to revolutionize therapy for hearing disorders. Advances in our understanding of the molecular basis of hearing combined with techniques for intracochlear gene transfer are leading us closer to clinical applications. Potential areas of interest are reviewed and experimental success using adeno-associated virus to effect intracochlear gene transfer is discussed.
Wareing
M J
MJ
Department of Otolaryngology-Head & Neck Surgery, University of California San Francisco, 94117, USA.
Lalwani
A K
AK
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006311:Hearing Disorders / Q000235:genetics / Q000628:therapy*; D006801:Humans; D014780:Viruses