Differences in resistance of C57BL/6 and C57BL/10 mice to infection by Mycobacterium avium are independent of gamma interferon.
After infection with a low-virulence strain of Mycobacterium avium, C57BL/6 and C57BL/10 mice had clear differences in the control of the infection in their livers and spleens. This difference in susceptibility was not associated with differences in the H-2 complex. It was dependent on the activity of CD4(+) T cells but unrelated to the ability of these cells to secrete gamma interferon or to the development of delayed-type hypersensitivity responses at 3 weeks of infection. It was associated with lower total numbers of CD4(+) cells present in infected spleens and was related to an earlier induction of protective T cells, as measured by adoptive-transfer assays. These data further strengthen the notion of gamma-interferon-independent mechanisms of protection against mycobacteria.
Appelberg
R
R
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal. rappelb@ibmc.up.pt
Leal
I S
IS
Pais
T F
TF
Pedrosa
J
J
Flórido
M
M
D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed; D007371:Interferon-gamma / Q000378:metabolism; D008099:Liver / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D009162:Mycobacterium avium / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D013045:Species Specificity; D013154:Spleen / Q000276:immunology / Q000382:microbiology; D014376:Tuberculosis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D014774:Virulence / Q000235:genetics / Q000276:immunology
D007371:Interferon-gamma