title: Dental amalgam mercury exposure in rats.
abstract: The aim of this study was to measure the distribution of mercury, in tissues of rats exposed to amalgam over a two months period. Possible interaction of mercury with copper and zinc in organs was also evaluated. Rats were either exposed to mercury from 4 dental amalgams, or fed the diet containing powdered amalgam during two months. Mercury was measured in the kidney, liver and brain, copper in kidney and brain and zinc in kidney. The results showed significantly higher concentrations of mercury in the kidneys and the brains of rats in both exposed groups compared to control. Even after two months of exposure to mercury brain mercury concentration in rats with amalgam fillings was 8 times higher than in the control and 2 times higher than in rats exposed to amalgam supplemented diet. The highest mercury concentration in the latter group was found in the kidneys and it was 5 times higher than in the control group. We found no significant differences between mercury levels in exposed and control rat's liver. Exposure to mercury from dental amalgams did not alter the concentrations of copper and zinc in the tissues. Histopathological analyses of rats tissues did not show any pathological changes. These results support previously proposed nose-brain transport of mercury released from dental amalgam fillings.
authors.affiliation: Department of Dental Pathology, School of Dentistry, Zagreb, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Galić
authors.forename: G
authors.initials: G
authors.lastname: Prpić-Mehicić
authors.forename: L
authors.initials: L
authors.lastname: Prester
authors.forename: M
authors.initials: M
authors.lastname: Blanusa
authors.forename: Z
authors.initials: Z
authors.lastname: Krnić
authors.forename: Z
authors.initials: Z
authors.lastname: Ferencić
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D003300:Copper / Q000493:pharmacokinetics; D003723:Dental Amalgam / Q000493:pharmacokinetics*; D015921:Dental Implants; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D015032:Zinc / Q000493:pharmacokinetics
chemical_list: D015921:Dental Implants; D003300:Copper; D003723:Dental Amalgam; D008628:Mercury; D015032:Zinc