title: Lipidemic effects of an interesterified mixture of butter, medium-chain triacylglycerol and safflower oils.
abstract: The objective of this study was to determine if the positional structure of dietary triacylglycerol affected lipidemic responses. Thirty healthy adults (16 men and 14 postmenopausal women) with low-density lipoprotein cholesterol (LDL-C) concentrations >3.37 mM (130 mg/dL) enrolled in a prospective, single-blind, cross-over outpatient clinical trial that consisted of two 5-wk dietary phases. After baseline screening, subjects were instructed to follow individualized meal plans (weight maintenance diets with 36% of total energy from fat, half of which was from a test oil) and randomized to receive either butter (B) or an interesterified mixture (IM) of butter, medium-chain triacylglycerol (MCT), and safflower oils. Blood drawn during weeks 5 and 10 of feeding was analyzed for total cholesterol (TC), high density lipoprotein cholesterol (HDL-C),LDL-C, and triacylglycerols (TAG). Mean plasma levels of TC (B, 6.98+/-1.06 mM; IM, 7.09+/-1.20 mM), HDL-C (B,1.30+/-0.35 mM; IM, 1.29+/-0.34 mM), and LDL-C (B, 4.91+/-0.95 mM; IM, 4.92+/-1.10 mM) were not significantly different between the two dietary treatments. Mean TAG levels were higher for the interesterified B-MCT mixture (B, 1.75+/-0.72 mM; IM, 1.96+/-0.86 mM, P < 0.05). We conclude that an IM of B, MCT, and safflower oils as compared to native B has no appreciable effect on plasma cholesterol concentrations but is associated with a modest rise in plasma TAG.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA. Edward.mascioli@parexel.com
authors.forename: E A
authors.initials: EA
authors.lastname: Mascioli
authors.forename: C E
authors.initials: CE
authors.lastname: McLennan
authors.forename: E J
authors.initials: EJ
authors.lastname: Schaefer
authors.forename: A H
authors.initials: AH
authors.lastname: Lichtenstein
authors.forename: C E
authors.initials: CE
authors.lastname: Høy
authors.forename: M S
authors.initials: MS
authors.lastname: Christensen
authors.forename: B R
authors.initials: BR
authors.lastname: Bistrian
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D000428:Alcohol Drinking; D001823:Body Composition; D002079:Butter; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004951:Esterification; D005227:Fatty Acids / Q000008:administration & dosage / Q000737:chemistry; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D017698:Postmenopause; D012450:Safflower Oil / Q000008:administration & dosage*; D014280:Triglycerides / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids; D014280:Triglycerides; D012450:Safflower Oil; D002079:Butter