DsbA: a protein-folding catalyst contributing to bacterial virulence.
DsbA, a periplasmic thiol:disulphide oxidoreductase, catalyses the folding of various factors, among which are virulence determinants or the components of type III secretory machinery. It is also necessary for intracellular survival and cell-to-cell spread of the intracellular pathogen Shigella flexneri.
Yu
J
J
Department of Paediatrics, Imperial College School of Medicine, St. Mary's Hospital, London, UK.
Kroll
J S
JS
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism; D001693:Biological Transport, Active; D010861:Fimbriae, Bacterial / Q000502:physiology; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000201:enzymology / Q000378:metabolism / Q000472:pathogenicity*; D006367:HeLa Cells / Q000382:microbiology / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D009154:Mutation; D010084:Oxidation-Reduction; D019897:Periplasm / Q000201:enzymology; D010944:Plants / Q000382:microbiology; D019704:Protein Disulfide-Isomerases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017510:Protein Folding; D012763:Shigella flexneri / Q000166:cytology / Q000201:enzymology / Q000378:metabolism / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D019704:Protein Disulfide-Isomerases