Tentative minimum inhibitory concentration and zone diameter breakpoints for moxifloxacin using BSAC criteria.
Tentative MIC and zone diameter breakpoints were determined for moxifloxacin using BSAC criteria. An MIC breakpoint of < or =1 mg/L, denoting sensitivity, is suggested for Enterobacteriaceae, staphylococci, haemophili, moraxellae, pneumococci and enterococci. For pseudomonads high and low breakpoints of 4 mg/L and 1 mg/L are suggested to allow for an intermediate category of sensitivity. A 1 microg moxifloxacin disc content is suggested for testing all of the organisms previously mentioned, except pseudomonads, for which a 5 microg disc is needed to discriminate between the intermediate and sensitive populations. Corresponding zone diameter breakpoints for a 1 microg disc are > or = 20 mm for Enterobacteriaceae and staphylococci, 18 mm for the respiratory pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis) and 15 mm for enterococci. For Pseudomonas aeruginosa with a 5 microg disc, three bands are suggested for interpretation, that of > or = 25 mm (sensitive), 18-24 mm (intermediate) and < or = 17 mm (resistant).
Andrews
J M
JM
Department of Antimicrobial Chemotherapy, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK.
Ashby
J P
JP
Jevons
G M
GM
Wise
R
R
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards*; D000077266:Moxifloxacin; D011804:Quinolines
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin