title: Gynecologic oncologic surgery in the elderly: A retrospective analysis of 213 patients.
abstract: OBJECTIVE
  The aims of the study were (1) to analyze morbidity and mortality for elderly women (>/=70 years) operated on for gynecological malignancies at our department between 1985 and 1996; and (2) to compare two periods of time (years 1985-1990 versus years 1991-1996) to investigate whether new expedience in the surgical technique as well as in the perioperative management introduced by 1991 influenced the feasibility and tolerability of surgery in elderly patients.
  
  
  METHODS
  In a retrospective analysis, we evaluated tumor site, comorbidities, surgical features, morbidity, and mortality. By 1991, several modifications in management were introduced, including: (1) early postoperative mobilization; (2) self-donation with autologous blood transfusion; (3) intraoperative antibiotic prophylaxis; (4) the retroperitoneum was left open and drains were not used after pelvic and aortic lymphadenectomy; (5) use of coagulator forceps and hemoclips for meticolous hemostasis.
  
  
  RESULTS
  In 213 patients, tumor site distribution was uterine corpus n = 93, ovary n = 51, vulva n = 29, cervix n = 23, breast n = 15, and vagina n = 2. There were advanced stage diseases in 47%, comorbid illnesses in 76%, and high surgical risk in 48%. Sixty-nine patients (group A) and 144 patients (group B) were treated in the first and second study periods, respectively. Overall, severe postoperative morbidity and mortality were 17 and 2.8%, respectively. Group B compared to group A showed more frequent use of major surgical procedures (P < 0.01) and lymphadenectomy (P < 0.04), lower transfusion rate (P < 0.001), reduced severe morbidity (P < 0.002), lower mortality (P = 0.3), and shorter hospital stay (P < 0.001).
  
  
  CONCLUSIONS
  Our study suggests that surgery, including very radical procedures, is reasonably feasible and well tolerated by elderly patients. The introduction of technical and medical advances in the later years of the study resulted in a significant improvement of surgical rates.
authors.affiliation: Istituto di Ginecologia e Ostetricia, Università Cattolica del Sacro Cuore, Rome, 00168, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Susini
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.forename: P A
authors.initials: PA
authors.lastname: Margariti
authors.forename: R
authors.initials: R
authors.lastname: Giannice
authors.forename: P
authors.initials: P
authors.lastname: Signorile
authors.forename: P
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005833:Genital Neoplasms, Female / Q000601:surgery*; D006801:Humans; D010051:Ovarian Neoplasms / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000601:surgery; D014625:Vaginal Neoplasms / Q000601:surgery; D014846:Vulvar Neoplasms / Q000601:surgery