Studies of the active substances in herbs used for hair treatment. III. Isolation of hair-regrowth substances from Polygara senega var. latifolia TORR. et GRAY.
Four active principles, 1, 2, 3 and 4, were isolated from Polygara senega var. latifolia TORR. et GRAY by a combination of partition and column chromatography on silica gel and octadecyl silica gel (ODS), monitored by a hair-regrowth activity assay. Compounds 1, 2, 3 and 4 were identified as senegose A, senegin II, senegin III, and senegasaponin b by comparison of their spectral data with those of authentic samples.
Ishida
H
H
School of Pharmaceutical Science, University of Shizuoka, Japan.
Inaoka
Y
Y
Okada
M
M
Fukushima
M
M
Fukazawa
H
H
Tsuji
K
K
D000818:Animals; D002850:Chromatography, Gel; D006197:Hair / Q000187:drug effects / Q000254:growth & development*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008809:Mice, Inbred C3H; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D010936:Plant Extracts