Oligogenic model selection using the Bayesian Information Criterion: linkage analysis of the P300 Cz event-related brain potential.
The traditional likelihood-based approach to hypothesis testing may not be an optimal strategy for evaluating oligogenic models of inheritance. Under oligogenic inheritance the number of possible multilocus models can become very large; there may be several competing linkage models having similar likelihoods; and comparisons among non-nested models can be required to determine if a given multilocus model provides a significantly better fit to observed phenotypic variation than an alternative model. We propose an efficient Bayesian approach to oligogenic model selection that makes use of existing model likelihoods, and show how model uncertainty can be incorporated into parameter estimation.
Blangero
J
J
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Williams
J T
JT
Iturria
S J
SJ
Almasy
L
L
D000437:Alcoholism / Q000235:genetics; D001499:Bayes Theorem; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D019655:Quantitative Trait, Heritable