Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues.
A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.
Jew
S
S
College of Pharmacy, Seoul National University, Korea.
Kim
H J
HJ
Kim
M G
MG
Roh
E Y
EY
Hong
C I
CI
Kim
J K
JK
Lee
J H
JH
Lee
H
H
Park
H
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002166:Camptothecin