title: Utilisation of prophylactic mastectomy in 10 European centres.
abstract: Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol including at least two risk counselling sessions and a psychological assessment. Thus far the combined centres have data on 174 women who have undergone prophylactic mastectomy with in excess of 400 women years of follow up. Operations were carried out on women with lifetime risks of 25-80%, with an average annual expected incidence rate of 1% per women. No breast cancers have occurred in this cohort. Long term follow up on an extended group of women will be necessary to truly address the risk of subsequent breast cancer and the psychological sequelae.
authors.affiliation: Department of Medical Genetics, St Mary's Hospital Manchester, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
authors.forename: E
authors.initials: E
authors.lastname: Anderson
authors.forename: F
authors.initials: F
authors.lastname: Lalloo
authors.forename: H
authors.initials: H
authors.lastname: Vasen
authors.forename: M
authors.initials: M
authors.lastname: Beckmann
authors.forename: D
authors.initials: D
authors.lastname: Eccles
authors.forename: S
authors.initials: S
authors.lastname: Hodgson
authors.forename: P
authors.initials: P
authors.lastname: Møller
authors.forename: J
authors.initials: J
authors.lastname: Chang-Claude
authors.forename: P
authors.initials: P
authors.lastname: Morrison
authors.forename: D
authors.initials: D
authors.lastname: Stoppa-Lyonnet
authors.forename: M
authors.initials: M
authors.lastname: Steel
authors.forename: N
authors.initials: N
authors.lastname: Haites
mesh_terms: D000328:Adult; D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D015331:Cohort Studies; D005060:Europe; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D019398:Genes, BRCA1; D005817:Genetic Counseling / Q000458:organization & administration; D005820:Genetic Testing; D006801:Humans; D016462:Mammaplasty; D008408:Mastectomy / Q000706:statistics & numerical data*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control*; D009857:Oncogenes; D010353:Patient Education as Topic; D012306:Risk; D014157:Transcription Factors / Q000235:genetics
chemical_list: D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors