A comparison of some allele-sharing based linkage analysis methods for detecting complex trait loci.
Using randomly selected sib pairs from a subset of the GAW11 simulated data in Problem 2, we compared the results of some linkage analysis methods based on allele sharing. One method was the Haseman-Elston test for a binary disease outcome (unaffected vs. mild or severe). The other methods, which analyzed the trinary ordered outcome unaffected/mild/severe were the Haseman-Elston test, an extended Haseman-Elston incorporating sib-pair sums, variance components analysis, and regression analysis. Our analysis was done without knowledge of the generating model.
Liu
Y
Y
Department of Public Health Sciences, University of Toronto, Ontario, Canada.
Mirea
L
L
Pinnaduwage
D
D
Fallah
S
S
Tritchler
D
D
D000483:Alleles; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009679:Nuclear Family; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis