Azathioprine-associated acute myeloid leukaemia with trilineage dysplasia and complex karyotype: a case report and review of the literature.
A 66-year-old female with dermatomyositis (DM) who had received immunosuppressive therapy with azathioprine developed acute myeloid leukaemia (AML). Cytogenetic analysis revealed a complex karyotype including monosomy 7, and trilineage dysplastic features strongly suggestive of a treatment-related aetiology. The literature on azathioprine-associated AML is reviewed.
Arnold
J A
JA
Department of Haematology, St Mary's NHS Trust and St Mary's Hospital Campus of Imperial College School of Medicine, London, UK.
Ranson
S A
SA
Abdalla
S H
SH
D000208:Acute Disease; D000368:Aged; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003882:Dermatomyositis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007951:Leukemia, Myeloid / Q000139:chemically induced* / Q000235:genetics
D007166:Immunosuppressive Agents; D001379:Azathioprine