title: Evidence and mechanisms of immunosuppression in tick infestations.
abstract: The abundance and ubiquity of ticks from ancient times long ago suggested that they have eluded host immunity. In the last 15 years, several authors have demonstrated suppression of the Th1 responses (cell-mediated immunity), and sometimes the Th2 responses (humoral immunity), subsequent to tick infestations in laboratory and natural models. Although the mechanisms to produce suppression are not well-defined yet, evidences for antigenic competition, lymphocyte cytotoxicity, presence of immuno-inhibiting substances in the saliva, and existence of modulators of cytokines in salivary extracts have been reported. Management of tick-induced immunosuppression is essential to replace tick control by acaricide application with more environmentally sound vaccination.
authors.affiliation: Programna de Parasitologia, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago. obarriga@machi.med.uchile.cl
authors.forename: O O
authors.initials: OO
authors.lastname: Barriga
mesh_terms: D000818:Animals; D001096:Arachnid Vectors / Q000276:immunology*; D002417:Cattle / Q000276:immunology / Q000469:parasitology; D002418:Cattle Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control; D006168:Guinea Pigs; D006790:Host-Parasite Interactions; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D016131:Lymphocyte Subsets / Q000276:immunology; D011817:Rabbits; D012463:Saliva / Q000276:immunology; D012756:Sheep / Q000276:immunology / Q000469:parasitology; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology; D013984:Tick Infestations / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary; D013987:Ticks / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary