title: Increased resting energy expenditure is related to plasma TNF-alpha concentration in stable COPD patients.
abstract: The objective of this study was to test whether increased resting energy expenditure (REE) in chronic obstructive pulmonary disease (COPD) patients is related to increased cost of breathing and/or to increased cytokine production. In 36 non-inflammatory (CRP: 17.6 +/- 13.1 mg.l(-1), mean +/- SD; orosomucoid: 0.71 +/- 0.18 g.l(-1)), non-malnourished (BMI: 23.6 +/- 4.3 kg.m(-2)), clinically stable, non severely hypoxic COPD patients (60.5 +/- 8.9 years) we measured REE, pulmonary function and plasma cytokine concentrations (TNF-alpha, IL1 and IL6). REE was increased by 10 +/- 11% (P< 0.001) above predicted values. Plasma TNF-alpha concentration was increased in all patients (mean value 26.3 +/- 14.3 pg.ml(-1)). Excess REE (with respect to values predicted by Harris-Benedict equations) was correlated with plasma TNF-alpha concentration (P< 0.005), but not with the degree of airway obstruction, lung overinflation, or with oxygen cost of breathing. Theophylline treatment resulted in a significant increase in REE by 15%.
  
  
  CONCLUSIONS
  non-malnourished, clinically stable, non-severely hypoxic COPD patients display an increased REE that is related with plasma TNF-alpha concentration (without apparent systemic inflammation) and to theophylline treatment, but that is independent of parameters of respiratory function.
authors.affiliation: Laboratoire de Nutrition Humaine, Centre de Recherche en Nutrition Humaine-Auvergne, Clermont-Ferrand, France.
authors.forename: L T
authors.initials: LT
authors.lastname: Nguyen
authors.forename: M
authors.initials: M
authors.lastname: Bedu
authors.forename: D
authors.initials: D
authors.lastname: Caillaud
authors.forename: B
authors.initials: B
authors.lastname: Beaufrère
authors.forename: G
authors.initials: G
authors.lastname: Beaujon
authors.forename: M
authors.initials: M
authors.lastname: Vasson
authors.forename: J
authors.initials: J
authors.lastname: Coudert
authors.forename: P
authors.initials: P
authors.lastname: Ritz
mesh_terms: D001481:Basal Metabolism; D001823:Body Composition; D001993:Bronchodilator Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D013806:Theophylline / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D001993:Bronchodilator Agents; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D013806:Theophylline