Effects of various levels of dietary Lepidium sativum L. seeds in rats.
A toxicity study was made on Lepidium sativum L. seeds used in Saudi traditional medicine for the treatment of various ailments. Lepidium sativum L. seed fed to Wistar albino rats at 2% (w/w) was non-toxic, Ten percent (w/w) was toxic but not fatal and 50% (w/w) of the diet for 6 weeks was lethal and caused depression in growth rate and entero-hepato-nephrotoxicity. Organ lesions accompanied by anemia and leukopenia were correlated with alterations in serum AST and ALT activities and concentrations of total protein, cholesterol, urea, and other serum constituents.
Adam
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Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Al-Qassim, Saudi Arabia.
D000818:Animals; D001835:Body Weight / Q000502:physiology; D019607:Brassicaceae; D004032:Diet / Q000009:adverse effects*; D004435:Eating; D006128:Growth / Q000187:drug effects*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012529:Saudi Arabia; D012639:Seeds