Molecular pathogenesis of Bacillus anthracis infection.
This review summarizes the current knowledge pertaining to the pathogenesis of infection with Bacillus anthracis relative to the two exotoxins and the capsule. Emphasis is given to the structure and activities of the individual components of the exotoxins, their interaction with cells, and the response of macrophages to lethal toxin. Finally, results from vaccination studies are reviewed.
Little
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US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
Ivins
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D000818:Animals; D000881:Anthrax / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology; D001408:Bacillus anthracis / Q000276:immunology / Q000472:pathogenicity*; D016667:Bacterial Capsules / Q000737:chemistry / Q000276:immunology; D001427:Bacterial Toxins / Q000737:chemistry* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000096:biosynthesis; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D014774:Virulence
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; C030325:anthrax toxin