Effects of intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects.
We studied the effect of the intrathecal (i.t.) injection of clonidine (30, 60 and 90 microg) on the polysynaptic spinal reflexes (PSR) elicited by electrical stimulation of flexor reflex afferents (FRA), monosynaptic reflex and gait of 11 subjects with spinal cord injuries. The effect of clonidine administration on gait velocity, stride amplitude and duration was measured in eight subjects who were able to walk. Five subjects were able to walk after intrathecal injection of clonidine and three were not able to stand up. Three subjects improved their gait velocity after clonidine administration; one (S6) increased his stride amplitude; the two others decreased their cycle durations. The tibialis anterior seemed to be more regularly activated during gait. Spasticity was reduced dramatically (P<0.0001) after i.t. clonidine injection, but there was no statistically significant difference in the soleus H reflex (no effect on Hmax/Mmax). Clonidine administration decreased the amplitude of the early PSR (90-120 ms, N=4) and the threshold and maximal integrated EMG corresponding to the late response (140-450 ms, N=7). This effect was dose dependent (30, 60 and 90 microg). Placebo injection (N=4) caused no change. The changes in spinal reflexes, with a large reduction in spasticity, no change in motoneurone excitability and a large decrease in PSR, suggest that clonidine acts at a premotoneuronal level, possibly by presynaptic inhibition of group II fibres. The increase in gait velocity in three subjects could have been due to reduced spasticity or activation of spinal circuitry.
Rémy-Néris
O
O
Fondation Franco Americaine, Centre Jacques Calvé, 2 Esplanade Parmentier, F-62608 Berck-Sur-Mer Cedex, France.
Barbeau
H
H
Daniel
O
O
Boiteau
F
F
Bussel
B
B
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D003000:Clonidine / Q000627:therapeutic use*; D004576:Electromyography / Q000187:drug effects; D005260:Female; D005684:Gait / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007278:Injections, Spinal; D008124:Locomotion / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000188:drug therapy* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013979:Tibial Nerve / Q000187:drug effects / Q000502:physiology
D000316:Adrenergic alpha-Agonists; D003000:Clonidine