title: Role of the cytomegalovirus (CMV)-antigenemia assay as a predictive and follow-up detection tool for CMV disease in AIDS patients.
abstract: Forty-two patients were evaluated to determine the value of the CMV antigenemia (CMV-Ag) test as a follow-up marker as well as a prediction marker of CMV disease. Twenty patients were positive for at least one positive CMV-Ag assay and 9 of them developed CMV retinitis. With the threshold value (10 positive cells), sensitivity was 56% and specificity was 94%. The CMV-Ag assay, with the threshold value, produced high specificity, positive predictive value and negative predictive value but relatively poor sensitivity. Eight patients experienced CMV disease relapse a total of 16 times. At relapse, 8 of the 16 times showed negative for CMV-Ag assay; 7 underwent systemic maintenance while 1 underwent local maintenance. It is inferred that the CMV-Ag test is a poor follow-up marker to detect the relapse of CMV disease, particularly in patients undergoing systemic maintenance.
authors.affiliation: Department of Infectious Diseases, Institute of Medical Science, The University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
authors.forename: A
authors.initials: A
authors.lastname: Masunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Fujino
authors.forename: M
authors.initials: M
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Iwamoto
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000097:blood* / Q000276:immunology; D002648:Child; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification*; D017726:Cytomegalovirus Retinitis / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000097:blood* / Q000276:immunology; D011237:Predictive Value of Tests; D012008:Recurrence; D014763:Viral Matrix Proteins / Q000097:blood* / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D010750:Phosphoproteins; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa