title: [Local treatment during angioplasty].
abstract: Intracoronary thrombosis and post-angioplasty complications (acute occlusion) are now controlled. Restenosis is the principal obstacle to transluminal coronary revascularisation. The conviction of the multifactorial and focal nature of the process leading to this excessive scarring is acquired. Constrictive remodelling is now established as the main mechanism of restenosis. Failure to prevent restenosis by systemic therapy has led several groups to experiment local treatment for this problem. The object of this article is to review the different systems of local treatment at the site of angioplasty. Even if some results are encouraging, there is no solution as yet to the problem of restenosis. Although local therapy is possible, the agent(s) of choice remain(s) to be defined.
authors.affiliation: Département de cardiologie, CHU Robert-Debre, Reims.
authors.forename: C
authors.initials: C
authors.lastname: Brasselet
authors.forename: F
authors.initials: F
authors.lastname: Addad
authors.forename: P
authors.initials: P
authors.lastname: Lemarchand
authors.forename: A
authors.initials: A
authors.lastname: Lafont
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D001918:Brachytherapy; D003327:Coronary Disease / Q000628:therapy*; D003328:Coronary Thrombosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D015607:Stents; D020257:Ventricular Remodeling
chemical_list: D010975:Platelet Aggregation Inhibitors
vernacular_title: Traitement local lors de l'angioplastie.