title: Studies of the active substances in herbs used for hair treatment. II. Isolation of hair regrowth substances, acetosyringone and polyporusterone A and B, from Polyporus umbellatus Fries.
abstract: Fractionation of the 50% ethanol extract of Polyporus umbellatus Fries by column chromatography on Amberlite XAD-2, silica gel, Sephadex LH-20 and octadecyl silica gel (ODS) (C18)) monitored by a hair-regrowth activity assay, afforded three active principles, 1, 2 and 3. The structures of 1, 2 and 3 were determined as acetosyringone, polyporusterone A, and polyporusterone B by comparison of their spectral data with that of authentic samples, respectively. The effects of several compounds related to acetosyringone, 3,4-dihydroxybenzaldehyde or polyporusterone A on hair regrowth were also investigated.
authors.affiliation: School of Pharmaceutical Science, University of Shizuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: Y
authors.initials: Y
authors.lastname: Inaoka
authors.forename: J
authors.initials: J
authors.lastname: Shibatani
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000302:isolation & purification / Q000494:pharmacology; D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D018360:Crystallography, X-Ray; D004441:Ecdysterone / Q000302:isolation & purification / Q000494:pharmacology; D006197:Hair / Q000254:growth & development*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011124:Polyporaceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001547:Benzaldehydes; D002396:Catechols; C005581:protocatechualdehyde; D004441:Ecdysterone