title: Linkage analysis in alcohol dependence.
abstract: Alcohol dependence often is a familial disorder and has a genetic component. Research in causative factors of alcoholism is coordinated by a multi-center program, COGA [The Collaborative Study on the Genetics of Alcoholism, Begleiter et al., 1995]. We analyzed a subset of the COGA family sample, 84 pedigrees of Caucasian ancestry comprising 745 persons, 339 of whom are affected according to DSM-III-R and Feighner criteria. Using parametric and nonparametric methods, evidence for linkage was found on chromosome 1 (near markers D1S532, D1S1588, and D1S534), as well as on chromosome 15 (near marker D15S642). Other regions of the genome showed suggestive evidence for contributing loci. Related findings are discussed in recent publications investigating linkage in humans [Reich et al., 1998] and mice [Melo et al., 1996].
authors.affiliation: Institute for Medical Statistics, University of Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Windemuth
authors.forename: A
authors.initials: A
authors.lastname: Hahn
authors.forename: K
authors.initials: K
authors.lastname: Strauch
authors.forename: M P
authors.initials: MP
authors.lastname: Baur
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002884:Chromosomes, Human, Pair 15; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D018392:Genomic Imprinting; D006801:Humans; D008126:Lod Score; D008297:Male; D012737:Sex Factors; D012984:Software; D018709:Statistics, Nonparametric
chemical_list: D005819:Genetic Markers