Placental transfer of stobadine in rabbits.
Stobadine, a pyridoindole antioxidant, was investigated for its placental transfer and distribution in New Zealand white rabbits on the 27th day of gestation. The concentrations of stobadine were determined in maternal and foetal organs (plasma, brain, heart) at 30, 60, 120, and 360 minutes after oral administration of the drug in a dose of 5 mg/kg. The results obtained proved that after oral stobadine intake by rabbits at the stage of advanced pregnancy both maternal and foetal organs were under a certain drug level which could act protectively against oxidative stress--frequently occurring during late organogenesis, foetal stages and delivery, as well as during early postnatal development.
Ujházy
E
E
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Dubovický
M
M
Soltés
L
L
Faberová
V
V
Zemánek
M
M
Gajdosík
A
A
D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism; D002243:Carbolines / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D014018:Tissue Distribution
D000975:Antioxidants; D002243:Carbolines; C100106:dicarbine