A Two-Directional and Highly Convergent Approach for the Synthesis of the Tumor-Associated Antigen Globo-H.
The assembly of six readily available building blocks in five glycosylation steps affords the tumor-associated Globo-H hexasaccharide 1 without the need for any intermediate protecting group manipulations. The aminopropyl spacer is employed for conjugation to carrier proteins.
Zhu
T
Complex Carbohydrate Research Center, 220 Riverbend Road, Athens, GA 30605 (USA).
Boons
GJ