title: Hematologic neoplasia and the central nervous system.
abstract: Central nervous system (CNS) involvement with malignant cells is a well recognized complication of hematologic neoplasms. A number of disorders such as acute lymphoblastic leukemia and high grade lymphoma frequently involve the CNS and prophylactic therapy is advised. Disorders such as acute myeloid leukemia (AML) and multiple myeloma are less likely to be associated with CNS involvement. This series describes three cases of CNS involvement by malignant hematologic disease: myelomatous meningitis, CNS chloromas complicating AML, and primary lymphomatous meningitis.
authors.affiliation: Hematology Unit, Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA. rsham@rghnet.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Sham
authors.forename: P D
authors.initials: PD
authors.lastname: Phatak
authors.forename: P A
authors.initials: PA
authors.lastname: Kouides
authors.forename: J A
authors.initials: JA
authors.lastname: Janas
authors.forename: V J
authors.initials: VJ
authors.lastname: Marder
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002540:Cerebral Cortex / Q000473:pathology; D017809:Fatal Outcome; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008578:Meninges / Q000473:pathology*; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy