Malignant human renin producing paraganglionoma-localization with 123I-MIBG and treatment with 131I-MIBG.
A 22-year-old woman presenting severe hypertension and hypokalaemia is described. Initial evaluation showed a large tumour localized at the position of the left adrenal gland. Subsequent surgery temporarily relieved all signs and symptoms caused by the tumour. The symptoms relapsed after a 2-year disease-free interval. At re-evaluation, the tumour was shown to produce an uncontrolled secretion of renin, thus triggering aldosterone-dependent hypertension. This report describes the diagnosis, treatment and clinical course of this unique patient with a malignant paraganglionoma of adrenal origin.
Arver
S
S
Endocrinology and Diabetology, Karolinska Hospital Stockholm, Uppsala, Sweden. Stefan.arver@kbh.ki.se
Jacobsson
H
H
Cedermark
B
B
Hamberger
B
B
Lundell
G
G
Grimelius
L
L
Brismar
K
K
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins / Q000378:metabolism*; D010235:Paraganglioma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012083:Renin / Q000378:metabolism*
D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D012083:Renin