title: Adrenal insufficiency due to metastatic hepatocellular carcinoma.
abstract: A 73-year-old man with general malaise and nausea following a common cold diagnosed by a local physician was found to have multiple hepatocellular carcinomas with enlarged bilateral adrenal glands, combined with adrenal insufficiency. Hydrocortisone replacement improved the symptoms and laboratory findings. Autopsy findings revealed that each adrenal gland was completely replaced by the tumor measuring 11 cm in diameter, and no adrenal tissue was recognized. Histologically, the adrenal tumors, as well as the liver tumors, were moderately differentiated Edmondson type II hepatocellular carcinomas. This is a second report of adrenal insufficiency due to hepatocellular carcinoma as a primary site of metastatic adrenal tumor.
authors.affiliation: First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takamura
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: E
authors.initials: E
authors.lastname: Nohara
authors.forename: H
authors.initials: H
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Kagaya
authors.forename: T
authors.initials: T
authors.lastname: Urabe
authors.forename: S
authors.initials: S
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000556:secondary*; D000309:Adrenal Insufficiency / Q000097:blood / Q000209:etiology*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000150:complications* / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood
chemical_list: D009363:Neoplasm Proteins