Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature.
We report the case of a man with chronic myelocytic leukemia (CML) and a 46,XY,t(5;9;22) karyotype who developed acute myelocytic leukemia (AML) with a 45,X,t(8;21) karyotype 11 years after bone marrow transplantation (BMT) from his HLA-matched sister. Fluorescent in situ hybridization (FISH) studies and molecular analysis using short tandem repeat (STR) sequences proved the new leukemia to be of donor cell origin. Donor cell leukemia (DCL) after BMT is rare. Our review of the literature found 15 cases following BMT for leukemia and 2 cases after BMT for benign hematological disorders. In fewer than half the reported cases were molecular studies available to confirm the cytogenetic evidence for DCL, and the longest previously reported interval between BMT and DCL was 6 years.
Cooley
L D
LD
Department of Pathology and Laboratory Medicine, The University of Texas Medical School, Houston, Texas, USA.
Sears
D A
DA
Udden
M M
MM
Harrison
W R
WR
Baker
K R
KR
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005838:Genotype; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000209:etiology* / Q000235:genetics; D008297:Male; D020080:Tandem Repeat Sequences; D013997:Time Factors; D014019:Tissue Donors; D014178:Translocation, Genetic