Molecular evolution: aminoacyl-tRNA synthetases on the loose.
Modified versions - paralogs - of the catalytic domain of at least three different aminoacyl-tRNA synthetases have been found to serve catalytic or regulatory roles in other reactions. These findings suggest that the first modern tRNA-synthetases could have been derived from amino-acid biosynthetic enzymes.
Weiner
A M
AM
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, 06520-8024, USA. weiner@biomed.med. yale.edu
D000596:Amino Acids / Q000096:biosynthesis; D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D002384:Catalysis; D005057:Eukaryotic Cells / Q000201:enzymology; D019143:Evolution, Molecular; D006801:Humans; D000069497:Origin of Life; D011387:Prokaryotic Cells / Q000201:enzymology; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D000596:Amino Acids; D000604:Amino Acyl-tRNA Synthetases