Thymic disorders and myasthenia gravis: genetic aspects.
Myasthenia gravis (MG) is an autoimmune disease characterized by production of antibodies to acetylcholine receptor at the motor end-plate responsible for impairment of neuromuscular transmission. There is general agreement about the involvement of the thymus in the pathogenesis of MG, and thymic pathological changes are commonly found in MG patients. Genetic factors seem to play an important role in susceptibility to MG. As with other autoimmune diseases, genetic predisposition to MG probably involves multiple genes. Ample evidence suggests that genes within the major histocompatibility complex (MHC) are involved in susceptibility to autoimmune diseases. Both data from the literature and our findings indicate that different genes within the MHC could predispose to various forms of MG, and that particularly the tumour necrosis factor genes may play a role in the association between the different thymic disorders and MG.
Zelano
G
G
Institute of Human Anatomy, Catholic University, Rome, Italy. ibiau@rm.unicatt.it
Settesoldi
D
D
Lino
M M
MM
Batocchi
A
A
Evoli
A
A
Tonali
P A
PA
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D013945:Thymoma / Q000150:complications; D013952:Thymus Hyperplasia / Q000150:complications; D013953:Thymus Neoplasms / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha