Screening for acyclovir-resistant herpes simplex virus isolates from clinical samples.
The ID90 or ID50 values of acyclovir for the herpes simplex virus strains isolated in VGH-Taipei were determined by plaque reduction method. Twenty HSV isolates of 1980's (1980-1985) and thirty of 1990's (1990-1995) were subjected to plaque reduction assay for susceptibility test to acyclovir. There were fifteen HSV isolates of 1990's whose ID90 were higher than those of 1980's, indicating a trend of more acyclovir resistant isolates in 1990's.
Mah
I W
IW
Department of Laboratory Medicine, Veterans General Hospital, Taipei.
Kuo
B I
BI
Wei
H Y
HY
Tsai
C H
CH
Liu
W T
WT
D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells
D000998:Antiviral Agents; D000212:Acyclovir