title: [A case of post-irradiation lumbosacral radiculopathy successfully treated with corticosteroid and warfarin].
abstract: A 33-year-old man underwent post-operative radiation therapy for the left testicular anaplastic seminoma. One year later, the patient developed muscle weakness and sensory disturbance in the left lower extremity, and muscle weakness in the right lower extremity. MRI demonstrated linear and focal gadolinium (Gd) enhancement of the anterior portion of the lumbosacral roots within the cauda equina. The neurological symptoms improved after administration of corticosteroid and warfarin. Radiation myelopathy of this type was classified as "selective anterior horn cell injury or amyotrophy" by Reagan, and the site of the lesion was considered to be the lower motor neurons. However, based on the clinical and MRI findings, we proposed that the disease process was injury to the spinal nerve roots rather than the lower motor neurons. Recent neuropathological studies of this syndrome have demonstrated degeneration of the proximal spinal nerve roots. We consider that primary lesions of this syndrome occur in spinal nerve roots rather than in lower motor neurons, and "lumbosacral radiculopathy" is a more appropriate term for this condition.
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University.
authors.forename: T
authors.initials: T
authors.lastname: Anezaki
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: I
authors.initials: I
authors.lastname: Kawachi
authors.forename: K
authors.initials: K
authors.lastname: Sanpei
authors.forename: Y
authors.initials: Y
authors.lastname: Soma
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D011843:Radiculopathy / Q000188:drug therapy* / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D005938:Glucocorticoids; D014859:Warfarin; D008775:Methylprednisolone