title: Refractory symptomatic schizophrenia resulting from frontal lobe lesion: response to clozapine.
abstract: A 34-year-old man with a 10-year history of persistent auditory hallucinations and passivity delusions had failed to respond to a variety of conventional antipsychotic medications. He had a history of head trauma 8 years before the onset of psychiatric symptoms. Recent investigations revealed a post-traumatic infarct, situated in the left frontal lobe, on a magnetic resonance imaging scan. Treatment with clozapine for more than 2 years resulted in a marked improvement in his psychotic symptoms. The localization of the brain lesion may be related to the etiology of his symptoms and to the clinical response to clozapine.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Leicester, England, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Burke
authors.forename: S M
authors.initials: SM
authors.lastname: Dursun
authors.forename: M A
authors.initials: MA
authors.lastname: Reveley
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005625:Frontal Lobe / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D016489:Head Injuries, Closed / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000503:physiopathology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine