title: Sentinel node biopsy for melanoma in the head and neck region.
abstract: BACKGROUND
  Lymphatic drainage in the head and neck region is known to be particularly complex. This study explores the value of sentinel node biopsy for melanoma in the head and neck region.
  
  
  METHODS
  Thirty consecutive patients with clinically localized cutaneous melanoma in the head and neck region were included. Sentinel node biopsy was performed with blue dye and a gamma probe after preoperative lymphoscintigraphy. Average follow-up was 23 months (range, 1-48).
  
  
  RESULTS
  In 27 of 30 patients, a sentinel node was identified (90%). Only 53% of sentinel nodes were both blue and radioactive. A sentinel node was tumor-positive in 8 patients. The sentinel node was false-negative in two cases. Sensitivity of the procedure was 80% (8 of 10).
  
  
  CONCLUSIONS
  Sentinel node biopsy in the head and neck region is a technically demanding procedure. Although it may help determine whether a neck dissection is necessary in certain patients, further investigation is required before this technique can be recommended for the standard management of cutaneous head and neck melanoma.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. LbJansen@nki.nl
authors.forename: L
authors.initials: L
authors.lastname: Jansen
authors.forename: H S
authors.initials: HS
authors.lastname: Koops
authors.forename: O E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: M H
authors.initials: MH
authors.lastname: Doting
authors.forename: B A
authors.initials: BA
authors.lastname: Kapteijn
authors.forename: A J
authors.initials: AJ
authors.lastname: Balm
authors.forename: A
authors.initials: A
authors.lastname: Vermey
authors.forename: J T
authors.initials: JT
authors.lastname: Plukker
authors.forename: C A
authors.initials: CA
authors.lastname: Hoefnagel
authors.forename: D A
authors.initials: DA
authors.lastname: Piers
authors.forename: B B
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009426:Netherlands; D011237:Predictive Value of Tests; D011379:Prognosis; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate