title: Multinucleated giant cell formation by microglia: induction by interleukin (IL)-4 and IL-13.
abstract: To investigate the cellular origin and the mechanisms of multinucleated giant cell (MGC) formation in the CNS, various cytokines were applied to isolated murine microglia. All the single cytokines failed to induce MGC. However, interleukin (IL)-13 and IL-4 induced microglial MGC formation in the presence of colony stimulating factors, which was inhibited by either anti-IL-13 or anti-fms antibody. T helper 2 (Th2)-derived cytokines can induce MGC formation even in the absence of infectious agents.
authors.affiliation: Department of Neurology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan. asuzumur@naramed-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Suzumura
authors.forename: T
authors.initials: T
authors.lastname: Tamaru
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Takayanagi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000276:immunology; D002478:Cells, Cultured; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D015726:Giant Cells / Q000166:cytology* / Q000187:drug effects; D018793:Interleukin-13 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000166:cytology* / Q000187:drug effects; D018418:Th2 Cells / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: D003115:Colony-Stimulating Factors; D018793:Interleukin-13; D016212:Transforming Growth Factor beta; D015847:Interleukin-4