title: Loop diathermy or laser excisional conization for cervical intraepithelial neoplasia.
abstract: BACKGROUND
  Cervical intraepithelial neoplasia (CIN) can be managed by ablative or excisional procedures. We have compared the excision time, effectiveness, and safety of loop diathermy (loop) against laser conization.
  
  
  METHODS
  In a prospective study in two hospital departments 222 women were randomized to loop or laser conization. Data were collected by questionnaires after operation and at two follow-up examinations.
  
  
  RESULTS
  At department A (122 women), two physicians performed 27% of the loop and 35% of the laser excisions; at department B (100 women), the corresponding figures were 69% and 59%. Loop was quicker than laser conization in both departments (median 3-4 min versus 10-20 min), while laser conization was more time consuming in department A (median A/B = 20/10 min). Peroperative bleeding dominated during the laser procedure in both departments and complicated the loop procedure more frequently in department A. Postoperative bleeding occurred with equal frequency in the four groups (41.8%, 52.7%, 59.2%, 64.7%). At both departments, bleeding for more than two weeks was reported twice as often after laser conization (A:13.8%, B:24.2%), when compared to loop excision (A:7.1%, B:13.7%). Residual CIN was found in all of three re-conizations and in one of eight hysterectomy specimens.
  
  
  CONCLUSIONS
  Loop was quicker than laser excision, per- and postoperative bleeding diminished, and the success rates were comparable. Physicians mastered Loop excision after a few attempts. However, the results improved, when performed by a restricted number of physicians. Histological incomplete excision indicates close colposcopic and cytologic follow-up to identify residual CIN.
authors.affiliation: Department of Obstetrics and Gynaecology, Copenhagen County Hospital Glostrup, Denmark.
authors.forename: L O
authors.initials: LO
authors.lastname: Vejerslev
authors.forename: L
authors.initials: L
authors.lastname: Schouenborg
authors.forename: F
authors.initials: F
authors.lastname: Sørensen
authors.forename: D
authors.initials: D
authors.lastname: Nielsen
authors.forename: S S
authors.initials: SS
authors.lastname: Sørensen
authors.forename: B R
authors.initials: BR
authors.lastname: Juhl
authors.forename: C
authors.initials: C
authors.lastname: Rygaard
authors.forename: J
authors.initials: J
authors.lastname: Junge
mesh_terms: D000328:Adult; D000368:Aged; D019092:Conization / Q000379:methods*; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000601:surgery*