Nuclear receptor regulation of cholesterol and bile acid metabolism.
The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.
Repa
J J
JJ
Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA.
Mangelsdorf
D J
DJ
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D005246:Feedback; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*
D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear; D002784:Cholesterol