Individual study of chromium in the stainless steel implants degradation: an experimental study in mice.
To study the accumulation and the histological effects in mice organs caused by hexavalent chromium, one of the corrosion products released from AISI 316L stainless steel implants, mice groups were subcutaneously injected with a metallic solution of chromium during a certain period of time. Similar injections were made with HBSS (Hank's Balanced Salt Solution) in other groups to be used as controls. The levels of chromium found in the liver, kidney and spleen of the control and the treated animals were obtained by atomic absorption spectrometry (AAS) and were compared to those obtained by AdSV (adsorptive stripping voltammetry) to test the accuracy of the results. During the experimental period, the liver and spleen showed a progressive and significant accumulation of chromium whereas in the kidney the significant accumulation found after the first week practically remained unchanged during the four weeks. Apparently, the histological analysis of these tissues did not evidence any relevant morphological alteration induced by the chromium accumulations during the four weeks of treatment.
Pereira
M do C
Mdo C
Departamento de Engenharia Química, FEUP, Porto, Portugal. mcsp@fe.up.pt
Pereira
M de L
Mde L
Sousa
J P
JP
D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002857:Chromium / Q000493:pharmacokinetics* / Q000494:pharmacology; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D019736:Prostheses and Implants; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013193:Stainless Steel; D014018:Tissue Distribution
D001672:Biocompatible Materials; D002857:Chromium; D013193:Stainless Steel