Angiosarcoma arising in a bone infarct.
A primary angiosarcoma of the femur arose in continuity with a bone infarct in a 74-year-old man. The tumor, resected by amputation, had pleomorphic polygonal and spindle cells in solid and cystic patterns with focal vasoformative features. The immunohistochemical stains CD31, CD34, factor VIII-related antigen, and Ulex europeus corroborated the endothelial differentiation of the tumor. The patient died after developing pulmonary metastases. This is the oldest reported patient with a well-documented angiosarcoma associated with a bone infarct.
Cerilli
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LA
Department of Pathology, The University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
Fechner
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RE
D000368:Aged; D000671:Amputation, Surgical; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005269:Femur / Q000098:blood supply*; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007238:Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D011859:Radiography