title: Improved techniques for kidney transplantation in the monkey.
abstract: Improved microsurgical techniques for kidney transplantation in the monkey are described. The left graft kidney is transplanted to the lower part of abdomen with end-to-side anastomoses of renal artery to aorta without a patch of aorta, renal vein to inferior vena cava, and end-to-end anastomosis of donor and recipient ureter with 8-0 nylon sutures in a bilateral nephrectomized recipient monkey. We recently performed 60 kidney transplantations in Vervet monkeys. None died of surgery or surgical complications. This reproducible model provides a useful tool to test new immunosuppressants and to investigate the mechanism of drug-induced tolerance and xenotransplantation in primates as a support to clinical trial.
authors.affiliation: Laboratory of Experimental Surgery, Research Center of CHUM, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Qi
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.forename: D
authors.initials: D
authors.lastname: Xu
authors.forename: M D
authors.initials: MD
authors.lastname: Vu
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008866:Microsurgery / Q000379:methods