title: The relationship between glycated hemoglobin and polymorphonuclear leukocyte leukotriene B4 release in people with diabetes mellitus.
abstract: In order to evaluate polymorphonuclear leukocyte (PMN) activity in diabetes mellitus, leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1 diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+/-0.2 pg/100 microl) in diabetic patients were higher compared to those of the control group (7.9+/-0.1 pg/100 microl) (P < 0.001), and remained significantly higher (P < 0.001) (12.8+/-0.2 pg/100 microl) than in the control group (11.0+/-0.2 pg/100 microl) after stimulation with calcium ionophore. A significant and positive correlation between glycated hemoglobin and LTB4 was demonstrated (P < 0.001, r = 0.80). This study demonstrates that in diabetic patients there is a PMN activation and that this activation is correlated to glycated hemoglobin level.
authors.affiliation: II Clinica Medica, Cattedra di Endocrinologia, Policlinico Umberto I, University of Rome La Sapienza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Parlapiano
authors.forename: C
authors.initials: C
authors.lastname: Danese
authors.forename: M
authors.initials: M
authors.lastname: Marangi
authors.forename: E
authors.initials: E
authors.lastname: Campana
authors.forename: P
authors.initials: P
authors.lastname: Pantone
authors.forename: T
authors.initials: T
authors.lastname: Giovanniello
authors.forename: E
authors.initials: E
authors.lastname: Zavattaro
authors.forename: S
authors.initials: S
authors.lastname: Sanguigni
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D000001:Calcimycin; D006442:Glycated Hemoglobin; D007975:Leukotriene B4