Systematic search for susceptibility genes in different populations.
We analyzed the first replicate of each of the four simulated population samples from three distinct populations by linkage and association genome scans and could identify three regions with susceptibility loci for the disease: on chromosome 1, marker D1G024, with strong evidence for gene x environment interaction; or chromosome 3, around marker D3G045; and on chromosome 5, markers D5G035-D5G042. Our results were obtained without knowing the true disease model and are compared with this model in the discussion.
Schmidt
S
S
Division of Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Scholz
M
M
Loesgen
S
S
Bickeböller
H
H
D000483:Alleles; D004777:Environment; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D019683:Penetrance; D015203:Reproducibility of Results; D012984:Software; D018709:Statistics, Nonparametric
D005819:Genetic Markers