title: Screening for acyclovir-resistant herpes simplex virus isolates from clinical samples.
abstract: The ID90 or ID50 values of acyclovir for the herpes simplex virus strains isolated in VGH-Taipei were determined by plaque reduction method. Twenty HSV isolates of 1980's (1980-1985) and thirty of 1990's (1990-1995) were subjected to plaque reduction assay for susceptibility test to acyclovir. There were fifteen HSV isolates of 1990's whose ID90 were higher than those of 1980's, indicating a trend of more acyclovir resistant isolates in 1990's.
authors.affiliation: Department of Laboratory Medicine, Veterans General Hospital, Taipei.
authors.forename: I W
authors.initials: IW
authors.lastname: Mah
authors.forename: B I
authors.initials: BI
authors.lastname: Kuo
authors.forename: H Y
authors.initials: HY
authors.lastname: Wei
authors.forename: C H
authors.initials: CH
authors.lastname: Tsai
authors.forename: W T
authors.initials: WT
authors.lastname: Liu
mesh_terms: D000212:Acyclovir / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D006801:Humans; D018139:Simplexvirus / Q000187:drug effects*; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir