Endophthalmitis from Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for bladder carcinoma.
OBJECTIVE
To present clinical and histologic findings of intraocular infection with Mycobacterium bovis-bacille Calmette-Guérin after intravesicular bacille Calmette-Guérin injections for treatment of bladder carcinoma.


METHODS
A 77-year-old man was initially seen with visual acuity of 20/200, focal retinitis, vasculitis, and progressive vitreous opacity in the right eye and visual acuity of light perception, intraocular inflammation, and a dense cataract in the left eye 14 months after intravesicular injection of live bacille Calmette-Guérin organisms.


RESULTS
Vitreous cultures in the right eye demonstrated growth of bacille Calmette-Guérin organisms. Bilateral loss of light perception occurred despite systemic antimy-cobacterial therapy. Histopathologic examination demonstrated nongranulomatous inflammation and acid-fast bacilli in both eyes.


CONCLUSIONS
Delayed endogenous endophthalmitis may develop after intravesicular bacille Calmette-Guérin injection that may not respond to systemic agents. Intravitreal therapy may be indicated.
Han
D P
DP
Medical College of Wisconsin, Milwaukee, USA. dhan@mcw.edu
Simons
K B
KB
Tarkanian
C N
CN
Moretti
S T
ST
D000368:Aged; D002277:Carcinoma / Q000628:therapy*; D009877:Endophthalmitis / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D005123:Eye / Q000473:pathology; D015353:Eye Enucleation; D006801:Humans; D007267:Injections; D008297:Male; D009164:Mycobacterium Infections / Q000209:etiology*; D009163:Mycobacterium bovis / Q000302:isolation & purification; D001749:Urinary Bladder Neoplasms / Q000628:therapy*; D014822:Vitreous Body / Q000382:microbiology