Fluid shear stress as a regulator of gene expression in vascular cells: possible correlations with diabetic abnormalities.
Diabetes mellitus is associated with increased frequency, severity and more rapid progression of cardiovascular diseases. Metabolic perturbations from hyperglycemia result in disturbed endothelium-dependent relaxation, activation of coagulation pathways, depressed fibrinolysis, and other abnormalities in vascular homeostasis. Atherosclerosis is localized mainly at areas of geometric irregularity at which blood vessels branch, curve and change diameter, and where blood is subjected to sudden changes in velocity and/or direction of flow. Shear stress resulting from blood flow is a well known modulator of vascular cell function. This paper presents what is currently known regarding the molecular mechanisms responsible for signal transduction and gene regulation in vascular cells exposed to shear stress. Considering the importance of the hemodynamic environment of vascular cells might be vital to increasing our understanding of diabetes.
Papadaki
M
M
Department of Chemical Engineering and Harvard-MIT Health Science and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Eskin
S G
SG
Ruef
J
J
Runge
M S
MS
McIntire
L V
LV
D000818:Animals; D001808:Blood Vessels / Q000378:metabolism / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000235:genetics / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D005786:Gene Expression Regulation; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical