Does deep brain stimulation of the nucleus ventralis intermedius affect postural control and locomotion in Parkinson's disease?
The purpose of this study was to evaluate the effect of unilateral stimulation of the nucleus ventralis intermedius (VIM) on parkinsonian signs like postural stability and locomotion with respect to the severity of Parkinson's disease (PD). Seven patients with idiopathic PD were included in the study. Changes in visual cues on postural stability and step initiation were assessed on a fixed platform system with VIM stimulation switched either on (VIM ON) or off (VIM OFF), and compared with a control group of seven age-matched normal individuals. Sway scores (area and path) were significantly (p <0.05) higher in the parkinsonian patients with VIM OFF than with VIM ON as well as compared with the control subjects. No correlation was obtained between extent of sway scores and severity of contralateral tremor after cessation of VIM stimulation. Locomotion parameters, by contrast, were not influenced by VIM stimulation: latency until step initiation and walking-cycle time were the same among parkinsonian patients as among normal individuals, both in the presence and in the absence of VIM stimulation. In conclusion, our results indicate that tremor suppression by VIM stimulation improves postural stability.
Pinter
M M
MM
Ludwig Boltzmann Institute of Restorative Neurology, Maria Theresien Schlössel Neurological Hospital, Hofzeile, Vienna, Austria.
Murg
M
M
Alesch
F
F
Freundl
B
B
Helscher
R J
RJ
Binder
H
H
D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D005260:Female; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D004856:Postural Balance / Q000502:physiology; D011187:Posture / Q000502:physiology*; D019736:Prostheses and Implants; D011930:Reaction Time / Q000502:physiology; D016896:Treatment Outcome; D014202:Tremor / Q000503:physiopathology / Q000628:therapy; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology*; D016138:Walking / Q000502:physiology