Synthesis of Tc-D,D-HMPAO and Tc-L,L-HMPAO and their comparison of chemical and biological properties.
Tc-D,D- and TC-L,L-HMPAO were synthesized. The stability of Tc-D,D- and TC-L,L-HMPAO in vitro is similar to that of d,l-isomers by the spectrophotometric and three strips methods. Cerebral uptake (%D in brain) for the L,L-isomer is higer than the D,D- and d,l-isomer in rats. Delayed studies shows that T-L,L-HMPAO reveals less washout and reflects a higher cerebral deposition properties than the D,D- and d,l-isomer.
Ding
H J
HJ
Department of Nuclear Medicine, School of Technology for Medical Sciences, Kaohsiung Medicial University, Taiwan.
Huang
Y F
YF
Tzeng
C C
CC
Wei
L M
LM
Yeh
S J
SJ
D000818:Animals; D005260:Female; D007536:Isomerism; D051381:Rats; D017208:Rats, Wistar; D019690:Technetium Tc 99m Exametazime / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D019690:Technetium Tc 99m Exametazime