Intracerebral hemorrhage outcome: apolipoprotein E genotype, hematoma, and edema volumes.
We investigated whether early hematoma or edema volumes could explain the adverse association between APOE epsilon4 and survival in intracerebral hemorrhage. Among 102 patients, epsilon4 carriers had a higher mortality rate than non-epsilon4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p<0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p<0.01), but these were not associated with epsilon4 after adjusting for race, age, and type of hemorrhage.
McCarron
M O
MO
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland, UK. mmc18f@clinmed.gla.ac.uk
Hoffmann
K L
KL
DeLong
D M
DM
Gray
L
L
Saunders
A M
AM
Alberts
M J
MJ
D000368:Aged; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001929:Brain Edema / Q000235:genetics* / Q000401:mortality; D002543:Cerebral Hemorrhage / Q000235:genetics* / Q000401:mortality; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006406:Hematoma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
D053327:Apolipoprotein E4; D001057:Apolipoproteins E