Usefulness of the epithelial tumor marker CA-125 in non-Hodgkin's lymphoma.
CA-125, a commonly used tumor marker for epithelial ovarian cancer, is a glycoprotein found in normal tissues derived from coelomic epithelia. Increased serum levels of CA-125 have also been found in nongynecologic tumors and nonmalignant diseases involving the peritoneum. A few recent studies and sporadic case reports have reported increased CA-125 levels in patients with non-Hodgkin's lymphoma (NHL). In our study, we aimed to evaluate the serum levels of CA-125 in patients with NHL and determine its potential role to show disease activity in NHL. Serum levels of CA-125 were measured in 61 patients with NHL and were found to be correlated with clinical stage, site of involvement, and disease activity.
Ozgüroglu
M
M
Department of Internal Medicine, Cerrahpasa School of Medicine, Istanbul University, Turkey.
Turna
H
H
Demir
G
G
Döventas
A
A
Demirelli
F
F
Mandel
N M
NM
Büyükünal
E
E
Serdengeçti
S
S
Berkarda
B
B
D000008:Abdominal Neoplasms / Q000473:pathology; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology; D018394:CA-125 Antigen / Q000032:analysis / Q000097:blood*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis; D010532:Peritoneal Diseases / Q000175:diagnosis; D011446:Prospective Studies; D001613:beta 2-Microglobulin / Q000032:analysis
D015415:Biomarkers; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D006023:Glycoproteins; D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase