title: Responses to potential vasoactive substances of isolated mammary blood vessels from lactating sows.
abstract: The purpose of the investigation was to examine the response of the milk vein and the mammary artery to potential vasoactive substances in lactating sows. The response on artery and vein segments from the same sow was measured for the following substances: noradrenaline (NA), serotonin (5-HT), prostaglandin F2alpha (PGF2alpha), prostacyclin (PGI2), histamine (Hi) and potassium (K+). Interestingly, the contractile force in the mammary vein segments expressed per weight unit (mN/mg) was 1.5-2.5 fold larger than in the artery segments when NA, 5-HT and PGF2alpha were used, but similar for K+, Hi and PGI2. In vein segments, the order of sensitivity to the substances expressed by their pD2 values was 5-HT > NA = PGF2alpha > Hi > K+. The present findings suggest that NA, 5-HT, PGF2alpha, PGI2, and Hi are involved in mammary blood flow regulation in the sow, and the mammary venous system may be as important as the mammary arterial system in this regulation.
authors.affiliation: Danish Institute of Agricultural Sciences, Research Centre Foulum, Department of Animal Product Quality, Tjele. hans.busk@agrsci.dk
authors.forename: H
authors.initials: H
authors.lastname: Busk
authors.forename: M T
authors.initials: MT
authors.lastname: Sørensen
authors.forename: E O
authors.initials: EO
authors.lastname: Mikkelsen
authors.forename: M O
authors.initials: MO
authors.lastname: Nielsen
authors.forename: K
authors.initials: K
authors.lastname: Jakobsen
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D005260:Female; D006632:Histamine / Q000494:pharmacology / Q000502:physiology; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology; D007774:Lactation; D008323:Mammary Arteries / Q000187:drug effects* / Q000502:physiology; D008321:Mammary Glands, Animal / Q000098:blood supply*; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology; D011188:Potassium / Q000494:pharmacology / Q000502:physiology; D011453:Prostaglandins / Q000494:pharmacology / Q000502:physiology; D011968:Receptors, Histamine / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology; D013552:Swine / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014680:Veins / Q000187:drug effects* / Q000502:physiology
chemical_list: D011453:Prostaglandins; D011968:Receptors, Histamine; D011985:Receptors, Serotonin; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D012701:Serotonin; D006632:Histamine; D007650:Ketanserin; D000241:Adenosine; D011188:Potassium; D009638:Norepinephrine