title: Response of vulvar lichen sclerosus and squamous cell hyperplasia to graduated topical steroids.
abstract: OBJECTIVE
  To determine whether symptomatic remission could be obtained equally effectively in patients with vulvar lichen sclerosus, squamous cell hyperplasia or mixed disease in response to a standardized course of graduated topical steroids.
  
  
  METHODS
  A retrospective analysis of 137 patients with biopsy-proven lichen sclerosus (84), squamous cell hyperplasia (42) or mixed disease (11) treated between 1990 and 1997 with a standard, three-month regimen of graduated topical steroids was carried out. Presence or absence of symptoms and side effects of treatment were recorded three and six months following induction of the initial graduated topical steroid regimen.
  
  
  RESULTS
  On completion of the graduated topical steroid course, 59% of patients were asymptomatic (P = .035), and at six months, 58% were asymptomatic (P = .11). Remission of symptoms was more easily achieved in patients with lichen sclerosus as compared to patients with squamous cell hyperplasia and mixed disease at both three and six months (P = .09 at three and P = .035 at six). Four cases of local reactions to the steroids were recorded, as were two cases of vulvar malignancy.
  
  
  CONCLUSIONS
  Symptomatic remission was significantly easier to achieve in patients with vulvar lichen sclerosus as compared to those with squamous cell hyperplasia following treatment with graduated topical steroids.
authors.affiliation: Department of Obstetrics and Gynaecology, Walsgrave Hospital, Coventry, U.K. tjclark@bham.ac.uk
authors.forename: T J
authors.initials: TJ
authors.lastname: Clark
authors.forename: I J
authors.initials: IJ
authors.lastname: Etherington
authors.forename: D M
authors.initials: DM
authors.lastname: Luesley
mesh_terms: D000287:Administration, Topical; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000188:drug therapy; D018459:Lichen Sclerosus et Atrophicus / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D013256:Steroids / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D013256:Steroids