title: Cytologic features of ovarian granulosa cell tumor metastatic to the lung. A case report.
abstract: BACKGROUND
  Granulosa cell tumor (GCT) of the ovary is an uncommon but not rare tumor, and the adult type usually affects postmenopausal women. The adult type of GCT has several characteristic clinicopathologic features, including a composition of small, uniform cells with Call-Exner bodies and an ability to metastasize to extrapelvic organs, even several decades after the initial operation.
  
  
  METHODS
  A 62-year-old female was incidentally found to have multiple shadows in the peripheral portions of both lung fields on roentgenography. She had a past history of oophorectomy for an ovarian carcinoma more than 20 years earlier. A transbronchial lung biopsy series was nondiagnostic. An aspirate obtained by transthoracic fine needle aspiration (FNA) biopsy revealed clusters of rather uniform, small cells with nuclear grooves, suggestive of a metastatic lung tumor. Histologic examination of the lung tissue in comparison with the previous oophorectomy specimen confirmed the impression of GCT metastatic to the lung.
  
  
  CONCLUSIONS
  A preoperative diagnosis of metastatic lung tumor was established by transthoracic FNA cytology. The important cytologic criteria for the differential diagnosis are uniformity of tumor cells, coffee bean-like nuclear grooves and Call-Exner bodies. The possibility of late recurrence of this kind of tumor, even two or three decades after surgical resection, should be kept in mind.
authors.affiliation: Department of Pathology, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: N
authors.initials: N
authors.lastname: Masawa
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000556:secondary; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*