[Functional organization and mechanisms of human intrinsic regulation of natural cytotoxicity system].
The paper gives a detailed account of the specific features and mechanisms of natural cytotoxicity (NCT) reactions in health and in disease. The assumption that the system autonomically functions has been substantiated and experimentally verified. There is evidence for that it is able to self regulate and to be controlled by endogenous or exogenous factors. If there is a biological expediency for NCT to be limited, which would prevented the intrinsic unchanged cells from lesions when they interact with the system's activated cells is first discussed. It has been found that there are three organizational levels of the mechanisms that rationally limit NCT. These include intra-systemic, extra-systemic endogenous and exogenous. The theoretical result of the studies is a basically new methodology of fundamental developments in the area of immunobiological surveillance. It assumes that environmental microbial factors have a limiting rather inducing influence on NCT, which prevents intact cells from lesions in cytotoxic reactions.
Cheknev
S B
SB
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007372:Interferons / Q000502:physiology; D008213:Lymphocyte Activation / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology
D007372:Interferons
Funktsional'naia organizatsiia i mekhanizmy vnytrenneĭ reguliatsii sistemy estestvennoĭ tsitotoksichnosti cheloveka.