Somatostatin reduces the meningeal arterial blood flow in the rat.
The effect of somatostatin (SOM) on neurogenic increases in meningeal blood flow was examined in barbiturate anaesthetized rats. The parietal skull was trepanized and the blood flow in the medial meningeal artery was monitored using a laser Doppler flowmeter with needle probes. Electrical stimulation (pulses of 8-10 V at 5-10 Hz for 30 s) close to the superior sagittal sinus evoked reproducible increases in blood flow. These increases were reduced by topical applications of SOM at concentrations of 10(-5)-10(-3) M in a dose-dependent manner. The effect was most pronounced within 10 min after application of SOM followed by a recovery of the flow responses. We conclude that stimulus-evoked increases in dural arterial flow, which are most likely caused by afferent activation and can be regarded as an element of neurogenic inflammation, are reduced by anti-inflammatory peptides such as SOM.
Pawlak
M
M
Physiologisches Institut der Universität Würzburg, Germany. matthias.pawlak@mail.uni-wuerzburg.de
Messlinger
K
K
Zehnter
A
A
Schmidt
R F
RF
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D017078:Laser-Doppler Flowmetry; D008576:Meningeal Arteries / Q000187:drug effects / Q000502:physiology*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013004:Somatostatin / Q000494:pharmacology / Q000502:physiology*
D013004:Somatostatin