title: Spindle cell hemangioma.
abstract: A 27-year-old woman presented with multiple nodules closely grouped on her right upper distal extremity. The lesions, dating from childhood, increased slowly in time. Microscopic examination of one nodule showed the histologic features of spindle cell hemangioendothelioma (SCH). At the periphery of the nodule there were also some features of the so-called sinusoidal hemangioma. Clinically, SCH can present as a solitary lesion or as multiple lesions in zonal distribution. When the lesions are multiple, the diagnosis of Maffucci's syndrome should be considered. SCH may be interpreted as a reactive process secondary to thrombosis and recanalization occurring in angiomatous lesions with different clinical presentations. Spindle cells are probably mesenchymal cells modified by blood pressure. For this entity the term hemangioma seems to be preferable to that of hemangioendothelioma.
authors.affiliation: Department of Dermatology, University of Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tomasini
authors.forename: F
authors.initials: F
authors.lastname: Aloi
authors.forename: E
authors.initials: E
authors.lastname: Soro
authors.forename: V
authors.initials: V
authors.lastname: Elia
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D004730:Endothelium, Vascular / Q000737:chemistry / Q000166:cytology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006225:Hand; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology*; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology; D006644:Histiocytes / Q000737:chemistry / Q000166:cytology; D006801:Humans; D007150:Immunohistochemistry; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII