Effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets.
Effects of beta-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as "points", which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. Beta-blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.
Mitsuda
M
M
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan.
Nomoto
M
M
Iwata
S
S
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002144:Callithrix; D005444:Flunarizine / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D018721:Muscarinic Agonists / Q000008:administration & dosage; D009529:Nicardipine / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology; D010095:Oxotremorine / Q000008:administration & dosage; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control*
D000319:Adrenergic beta-Antagonists; D002121:Calcium Channel Blockers; D018721:Muscarinic Agonists; D009553:Nimodipine; D010095:Oxotremorine; D009529:Nicardipine; D005444:Flunarizine