The IGF-I receptor in cancer research.
The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in experimental animals. However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation.
Baserga
R
R
Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, 624 BLSB, Philadelphia, Pennsylvania, 19107, USA. r_baserga@lac.jci.tju.edu
D000818:Animals; D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000209:etiology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D012106:Research / Q000639:trends*
D017526:Receptor, IGF Type 1