title: Mass volume measurement in severe head injury: accuracy and feasibility of two pragmatic methods.
abstract: OBJECTIVE
  To assess the clinical feasibility and the accuracy of two pragmatic methods in comparison with a conventional computer based method of measurement of masses from CT.
  
  
  METHODS
  Nineteen CT scans of 11 patients with severe head injury, showing 34 traumatic lesions, were examined. The volume of every lesion was digitally measured, then a panel of three examiners independently repeated the measurement using the ellipsoid and the Cavalieri method in random order.
  
  
  RESULTS
  All the lesions were identified by all the readers and the mean volume measured by each examiner differed by less than 1.5 ml. The average reading time for each scan was 4 minutes for the ellipsoid and 7 minutes for the Cavalieri method. The average volume of the lesions was 34.2 (SD 35) ml with the digital system, and 38.4 (SD 41) ml and 34.8 (SD 36) ml for the ellipsoid and the Cavalieri readings respectively. The average difference between the applied technique and the digital system was 0.57 (SD 9.99) ml for the Cavalieri direct estimator and 0.20 (SD 15.48) ml for the ellipsoid method. The 95% confidence interval for this difference fell between -2.75 and 3.89 ml for the Cavalieri, and between -4.94 and 5.35 ml for the ellipsoid method. There were 19 lesions >25 ml; the ellipsoid method identified 16 of them, whereas 17 were classified with the Cavalieri method. When considering individual lesions rather than the average volume, discrepancies were detected with both methods. The ellipsoid method was less precise, especially when extracerebral lesions were measured.
  
  
  CONCLUSIONS
  Both pragmatic methods are inferior to computer based reading, which is the choice when accurate volume estimation is necessary. However, if a digital volumetric determination of the lesions using a CT computer is not possible, the two pragmatic methods offer an alternative.
authors.affiliation: Neuroscience Intensive Care, Policlinico Hospital IRCCS Milano, Italy. stocchet@polic.cilea.it
authors.forename: N
authors.initials: N
authors.lastname: Stocchetti
authors.forename: M
authors.initials: M
authors.lastname: Croci
authors.forename: D
authors.initials: D
authors.lastname: Spagnoli
authors.forename: F
authors.initials: F
authors.lastname: Gilardoni
authors.forename: F
authors.initials: F
authors.lastname: Resta
authors.forename: A
authors.initials: A
authors.lastname: Colombo
mesh_terms: D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging*; D001930:Brain Injuries / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed