title: Automated scanning laser ophthalmoscope image montages of retinal diseases.
abstract: OBJECTIVE
  To generate wide-field automated seamless retinal montage images.
  
  
  METHODS
  Prospective, observational, case series study.
  
  
  METHODS
  Eighteen eyes of 14 patients were studied.
  
  
  METHODS
  A digital scanning laser ophthalmoscope (SLO), the Heidelberg Retina Angiograph (HRA), was used to obtain overlapping images of the fundus during fluorescein angiograms, indocyanine green angiograms, or monochromatic retinal imaging using infrared or green light. Software was used to generate seamless montages.
  
  
  METHODS
  Ability to electronically synthesize retinal montages. Four laser wavelengths were used. The wide-field degrees, vertical and horizontal number of pixels, and diameter of the individual images were measured.
  
  
  RESULTS
  High-resolution (pixel size, 10 microm), wide-field, typically 100 degrees to 140 degrees, digital montages of the postequatorial retina can be generated from HRA images.
  
  
  CONCLUSIONS
  The software automatically and rapidly aligned the retinal blood vessels and synthesized a montage of the entire fundus that could then be overlaid on images taken at different times to illustrate change. These montages will allow improved ability to understand and follow retinal diseases.
authors.affiliation: Shiley Eye Center, Department of Ophthalmology, University of California, San Diego, La Jolla 92093-0946, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Rivero
authors.forename: D U
authors.initials: DU
authors.lastname: Bartsch
authors.forename: T
authors.initials: T
authors.lastname: Otto
authors.forename: W R
authors.initials: WR
authors.lastname: Freeman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D007834:Lasers; D008875:Middle Aged; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy / Q000379:methods*; D012164:Retinal Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology*
chemical_list: D007208:Indocyanine Green