title: Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.
authors.affiliation: Microcide Pharmaceuticals Inc., 850 Maude Avenue, Mountain View, California 94043, USA. tomrenau@microcide.com
authors.forename: T E
authors.initials: TE
authors.lastname: Renau
authors.forename: R
authors.initials: R
authors.lastname: Léger
authors.forename: E M
authors.initials: EM
authors.lastname: Flamme
authors.forename: J
authors.initials: J
authors.lastname: Sangalang
authors.forename: M W
authors.initials: MW
authors.lastname: She
authors.forename: R
authors.initials: R
authors.lastname: Yen
authors.forename: C L
authors.initials: CL
authors.lastname: Gannon
authors.forename: D
authors.initials: D
authors.lastname: Griffith
authors.forename: S
authors.initials: S
authors.lastname: Chamberland
authors.forename: O
authors.initials: O
authors.lastname: Lomovskaya
authors.forename: S J
authors.initials: SJ
authors.lastname: Hecker
authors.forename: V J
authors.initials: VJ
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D004357:Drug Synergism; D010450:Endopeptidases / Q000378:metabolism; D015870:Gene Expression; D064704:Levofloxacin; D026901:Membrane Transport Proteins; D015394:Molecular Structure; D015242:Ofloxacin / Q000494:pharmacology*; D009952:Ornithine / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D004151:Dipeptides; D026901:Membrane Transport Proteins; C118598:MexA protein, Pseudomonas aeruginosa; C118597:MexB protein, Pseudomonas aeruginosa; C402263:OprM protein, Pseudomonas aeruginosa; C402264:phenylalanyl-N(alpha)-methylornithine 2-naphthyl amide; D064704:Levofloxacin; D015242:Ofloxacin; D009952:Ornithine; D010450:Endopeptidases