[Comparative study of HLA-DRB1 allele in patients with chronic bronchitis and bronchial asthma].
OBJECTIVE
To make a comparative study of HLA-DRB1 allele frequencies in the cases of chronic bronchitis and bronchial asthma.


METHODS
The authors investigated 74 patients with chronic bronchitis and 64 patients with bronchial asthma from among the Han people in Shanxi province. PCR/SSP technique was used for HLA-DRB1 typing, and the patients' data were compared with the normal controls'.


RESULTS
The frequency of HLA-DRB1*1201/1202(24.32%) was significantly increased in the chronic bronchitis group(P<0.01),and the frequency of HLA-DRB1*1501/1502(23.44%) was significantly increased in the bronchial asthma group(P<0.05). The frequencies of other DRB1 alleles were not significantly increased in these groups.


CONCLUSIONS
The results indicate that HLA-DRB1*1201/1202 allele is associated with chronic bronchitis and HLA-DRB1*1501/1502 allele is associated with bronchial asthma in the patients among the Hans in Shanxi province.
Wang
C
C
Department of Respiratory Diseases, The Second Hospital of Shanxi Medical University, Taiyuan 030001 P.R.China. Wangchonggang@263.net
Peng
Z
Z
Li
J
J
Liu
Z
Z
Song
M
M
D000483:Alleles; D001249:Asthma / Q000235:genetics* / Q000276:immunology; D001991:Bronchitis / Q000235:genetics* / Q000276:immunology; D002908:Chronic Disease; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains