Effects of a parathyroidectomy on the immune system and nutritional condition in chronic dialysis patients with secondary hyperparathyroidism.
BACKGROUND
Parathyroid hormone (PTH) has an adverse effect on the immune system and may cause immunologic disorders in patients with chronic renal failure. The in vivo effects of a parathyroidectomy on the immunologic parameters was examined.


METHODS
Thirty-four patients under dialysis therapy received a parathyroidectomy (PTx) for secondary hyperparathyroidism (HPT). They were prospectively studied regarding serum immunoglobulins, complements, CD markers, and serum soluble IL-2 receptor (sIL-2R) until 12 months after PTx.


RESULTS
The serum levels of IgG, IgA and IgM showed significant increase until 12 months after PTx (P<0.001, respectively). C3, C4, and CH50 also indicated significant increase at 12 months after PTx. In cellular immunity, only serum sIL-2R showed significant increase 2 weeks after PTx (P = 0.028). The hematocrit and serum albumin also improved significantly at 12 months.


CONCLUSIONS
PTx showed beneficial effects on humoral immunological markers. The effects are probably due to the remarkable PTH reduction and partly improved nutritional state after PTx.
Yasunaga
C
C
Kidney Center, Saiseikai Yahata Hospital, Kitakyushu, Japan.
Nakamoto
M
M
Matsuo
K
K
Nishihara
G
G
Yoshida
T
T
Goya
T
T
D000328:Adult; D000917:Antibody Formation; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000276:immunology* / Q000601:surgery; D007111:Immunity, Cellular; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D016105:Parathyroidectomy; D011446:Prospective Studies; D006435:Renal Dialysis; D013997:Time Factors