title: Defect of osmoregulatory renal function in nocturnal enuresis.
abstract: Renal function was studied in 62 children with primary nocturnal enuresis (PNE) and in 20 healthy children aged 6-15 years. During the night, children with PNE exhibited an increase in diuresis, free water reabsorption and solute excretion (including sodium and magnesium) in comparison to controls. Intranasal administration of Adiuretin-SD (10.5-24.5 micrograms) in the evening reduced diuresis and ion excretion to normal levels. During the treatment, 61% of the children became completely dry and, in 24% of the children, the number of wet nights was reduced by 50%. It is suggested that in the pathogenesis of PNE, the decrease in ion reabsorption in the thick ascending Henle's loop--resulting in a greater load of tubular fluid in the collecting ducts, an elevation of diuresis and increases in free water reabsorption and solute excretion--plays the leading role in disturbing renal function. Treatment of PNE with desmopressin is pathogenically justified, as it eliminates the principal defect of renal tubular function.
authors.affiliation: I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia.
authors.forename: Y V
authors.initials: YV
authors.lastname: Natochin
authors.forename: A A
authors.initials: AA
authors.lastname: Kuznetsova
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D004775:Enuresis / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects / Q000502:physiology; D007677:Kidney Function Tests; D008297:Male; D012016:Reference Values; D012076:Renal Agents / Q000008:administration & dosage; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology*
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin