EPR spectroscopy of free radical intermediates of antiarrhythmic-antihypoxic drug stobadine, a pyridoindole derivative.
Mechanisms of antioxidant action of stobadine, a pyridoindole derivative with cardioprotective and antihypoxic properties, has been probed using EPR spectroscopy. Oxidation of stobadine by PbO2/tBuOOH in benzene results in the formation of nitroxide radical observable directly by EPR spectroscopy at room temperature, indicating conversion of indolic amino group to the corresponding nitroxide.
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Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
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D000889:Anti-Arrhythmia Agents / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry; D010084:Oxidation-Reduction
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D002243:Carbolines; D003497:Cyclic N-Oxides; D005609:Free Radicals; C100106:dicarbine