title: Isolated lymph node T lymphoblastic transformation of chronic myeloid leukemia during interferon treatment.
abstract: Isolated nodal T lymphoblastic transformation of chronic myeloid leukemia (CML) with the marrow still in chronic phase is rare. A case of CML treated by alpha-interferon developed this unusual complication. However, after successful treatment of the blastic transformation, the patient remained responsive to interferon and maintained a major cytogenetic response for over 2 years. This case illustrated a rare clinical progression of CML on interferon treatment to isolated nodal T lymphoblastic transformation. This unusual form of blastic transformation may have a better prognosis than other forms of blastic crisis.
authors.affiliation: Department of Pathology, Queen Elizabeth Hospital, Hong Kong.
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: A C
authors.initials: AC
authors.lastname: Chan
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D016898:Interferon-alpha / Q000627:therapeutic use*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D016898:Interferon-alpha; D016044:Fusion Proteins, bcr-abl