Inhibitory activities of 2-pyridinecarboxylic acid analogs on phytogrowth and enzymes.
Five 2-pyridinecarboxylic acid-related compounds (1, 2 and 5-7) showed germination inhibition against the seed of Brassica campestris L. subsp. rapa HOOK fil et ANDERS at a concentration of 5.0 x 10(-4) M. These compounds also demonstrated inhibitory activity on the growth of the root of this plant at a concentration of 3.0 x 10(-4) M; among these compounds, 2-pyridylacetic acid (5) showed the strongest inhibitory activity, and the effect was slightly stronger than that of sodium 2,4-dichlorophenoxyacetate (2,4-D) used as a positive control. The amounts of chlorophyll in the cotyledons of this plant treated with these active compounds was lower than that of the control group. Four compounds (1 and 5-7) with germination inhibition also showed inhibitory activities against alpha-amylase and carboxypeptidase A, and 5 was the strongest inhibitor toward both enzymes.
Sakagami
Y
Y
Osaka Prefectural Institute of Public Health, Japan.
Tsujibo
H
H
Hirai
Y
Y
Yamada
T
T
Numata
A
A
Inamori
Y
Y
D001937:Brassica / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D043422:Carboxypeptidases A; D002734:Chlorophyll / Q000096:biosynthesis; D003864:Depression, Chemical; D018525:Germination / Q000187:drug effects; D018517:Plant Roots / Q000187:drug effects / Q000254:growth & development; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D012639:Seeds / Q000187:drug effects; D013329:Structure-Activity Relationship; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism
D002264:Carboxylic Acids; D011725:Pyridines; D002734:Chlorophyll; D000516:alpha-Amylases; D002268:Carboxypeptidases; D043422:Carboxypeptidases A