Value of Ga-67 SPECT in monitoring the effects of therapy in invasive aspergillosis of the sphenoid sinus.
OBJECTIVE
We report a case of invasive sphenoid sinus aspergillosis clinically presenting as a pituitary mass.


METHODS
After exploration via the trans-sphenoidal approach and subsequent treatment with amphotericin-B, Ga-67 brain SPECT was performed twice to monitor the therapeutic effect.


RESULTS
Three months after antifungal treatment, Ga-67 brain SPECT showed partial resolution of the lesion in the sella turcica region. The patient continued with fluconazole treatment for another 2 months and received another Ga-67 brain SPECT, which showed complete clearing of the previous lesion.


CONCLUSIONS
Ga-67 brain SPECT may play a potentially useful role in monitoring the therapeutic effect of treatment of invasive sphenoid sinus aspergillosis.
Tzen
K Y
KY
Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taipei Medical Center and School of Medicine, Chang Gung University, Taiwan. tzenky@mail.cgu.edu.tw
Yen
T C
TC
Lin
K J
KJ
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001921:Brain / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000627:therapeutic use; D005500:Follow-Up Studies; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D010254:Paranasal Sinus Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D010911:Pituitary Neoplasms / Q000175:diagnosis; D019275:Radiopharmaceuticals; D012658:Sella Turcica / Q000000981:diagnostic imaging; D013101:Sphenoid Sinus / Q000000981:diagnostic imaging / Q000187:drug effects / Q000382:microbiology*; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
D000935:Antifungal Agents; D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D000666:Amphotericin B; D015725:Fluconazole