Bone mineral density and androgen levels in elderly males.
To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55-90 years) the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied. BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between body mass index (BMI) and BMD at the lumbar spine and femoral neck (P < 0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related factors must be associated with bone loss in elderly males.
Rapado
A
A
Clínica de Na Sra de la Concepción, Fundación Jiménez Díaz, Madrid, Spain.
Hawkins
F
F
Sobrinho
L
L
Díaz-Curiel
M
M
Galvao-Telles
A
A
Arver
S
S
Melo Gomes
J
J
Mazer
N
N
Garcia e Costa
J
J
Horcajada
C
C
López-Gavilanes
E
E
Mascarenhas
M
M
Papapietro
K
K
López Alvarez
M B
MB
Pereira
M C
MC
Martinez
G
G
Valverde
I
I
García
J J
JJ
Carballal
J J
JJ
García
I
I
D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000502:physiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood*; D014809:Vitamin D-Binding Protein / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D014809:Vitamin D-Binding Protein; D015675:Osteocalcin; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone