[Severe anaphylactic reactions after administration of rocuronium].
The authors report four cases of severe anaphylactic reactions (grade III or IV) to rocuronium bromide. In three of them, it was the first contact with a muscle relaxant. In three patients the reaction was mediated by IgE anti-bodies. A cross-reactivity with other muscle relaxants was existing in two cases (suxamethonium, vecuronium and atracurium in one patient, suxamethonium, vecuronium and pancuronium in the other.
Barthelet
Y
Y
Département d'anesthésie-réanimation A, hôpital Lapeyronie, Montpellier, France.
Ryckwaert
Y
Y
Plasse
C
C
Bonnet-Boyer
M C
MC
d'Athis
F
F
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000276:immunology; D000732:Androstanols / Q000009:adverse effects*; D000906:Antibodies / Q000276:immunology; D001279:Atracurium / Q000009:adverse effects; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D010197:Pancuronium / Q000009:adverse effects; D000077123:Rocuronium; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects; D014673:Vecuronium Bromide / Q000009:adverse effects
D000732:Androstanols; D000906:Antibodies; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium; D007073:Immunoglobulin E; D014673:Vecuronium Bromide; D013390:Succinylcholine; D010197:Pancuronium; D000077123:Rocuronium
Accidents anaphylactiques graves après administration de rocuronium.