Synthesis and relative binding affinity to steroid receptors and antiproliferative activity on MCF-7 cells of 2,3-disubstituted indenes.
The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives.
Kirkiacharian
S
S
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud, Chatenay-Malabry, France. serge.kirkiacharian@cep.u-psud.fr
Koutsourakis
P G
PG
Philibert
D
D
Bouchoux
F
F
Van de Velde
P
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D011987:Receptors, Steroid / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007192:Indenes; D011987:Receptors, Steroid