title: Coexistent Hashimoto's thyroiditis with papillary thyroid carcinoma: impact on presentation, management, and outcome.
abstract: BACKGROUND
  This study was performed to assess the relationship between Hashimoto's thyroiditis and the development, presentation, management, and outcome of papillary thyroid carcinoma.
  
  
  METHODS
  Two complementary analytic methods were used. The clinical study was a retrospective case-control study, including patients seen with papillary thyroid carcinoma presenting during a 12-year period. We also used a systematic literature review to identify suitable reports and meta-analysis to statistically combine published results.
  
  
  RESULTS
  The prevalence of Hashimoto's thyroiditis is significantly higher in patients with papillary thyroid cancer (odds ratio, 1.89; 95% CI, 1.02-3.50). These patients typically have a dominant nodule, 44% of which are discovered incidentally on routine examinations. Fine-needle aspiration has a sensitivity of 91% for the identification of papillary cancer. The prognostic variables at the time of a diagnosis of papillary cancer and the approach to management are not altered by the presence of coexistent Hashimoto's thyroiditis. In addition, the rate of surgical complications was not higher in patients with coexistent Hashimoto's disease. Meta-analysis suggested a positive correlation between Hashimoto's disease and disease-free survival (r = 0.09; 95% CI, 0.05-0.12) and overall survival (r = 0.11; 95% CI, 0.07-0.15).
  
  
  CONCLUSIONS
  There is an increased prevalence of Hashimoto's thyroiditis in patients with papillary thyroid carcinoma. The presence of coexistent Hashimoto's thyroiditis does not affect the diagnostic evaluation or management of papillary thyroid cancers. The survival of patients who have papillary thyroid cancers may be superior in coexistent Hashimoto's thyroiditis.
authors.affiliation: Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: A R
authors.initials: AR
authors.lastname: Shaha
authors.forename: H
authors.initials: H
authors.lastname: Trivedi
authors.forename: J F
authors.initials: JF
authors.lastname: Carew
authors.forename: A
authors.initials: A
authors.lastname: Poluri
authors.forename: J P
authors.initials: JP
authors.lastname: Shah
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D013967:Thyroiditis, Autoimmune / Q000401:mortality* / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome