title: Synexpression groups in eukaryotes.
abstract: In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or 'synexpression groups', show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.
authors.affiliation: Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Niehrs
authors.forename: N
authors.initials: N
authors.lastname: Pollet
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism*; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D009876:Operon
chemical_list: D002784:Cholesterol