Altered cardiac tissue and plasma kininogen levels in hypertensive and diabetic rats.
The present investigation was aimed at evaluating the cardiac and total plasma kininogen levels, as well as LVWT in hypertensive and diabetic rats. STZ-induced diabetes produced a significant (P < 0.001) rise in mean arterial blood pressure (BP). The LVWT increased (P < 0.001) in SHR with and without diabetes) and diabetic WKYR. The cardiac tissue, as well as total plasma kininogen levels fell significantly (P < 0.001) in diabetic WKYR and SHR with and without diabetes compared to the control WKYR. These findings suggest that reduced kininogen levels may indicate a deficiency in kinin generation in the heart and in the peripheral circulation in diabetic and hypertensive rats. This effect may contribute to the development of LVH.
Sharma
J N
JN
Department of Pharmacology and Physiology, School of Pharmaceutical Sciences, Universiti Sains Malaysia. jnarain@usm.my
Kesavarao
U
U
Yusof
A P
AP
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007704:Kininogens / Q000032:analysis* / Q000097:blood; D008297:Male; D009206:Myocardium / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013311:Streptozocin
D001786:Blood Glucose; D007704:Kininogens; D013311:Streptozocin