title: Blood salvage in craniosynostosis surgery.
abstract: In the history of surgery, every single step forward in the development of complex surgical techniques has been sustained by the acquisition of more reliable and effective methods for controlling hemostasis. For many years, in fact, uncontrolled hemorrhages, together with infections, represented the most deadly hazard of surgical procedures. In the last century, technical advances in surgical hardware and homologous blood transfusions have been utilized to counteract operative and postoperative anemia and hypovolemia. At the end of this millennium, however, new revelations about the infective and noninfective risks of allogeneic blood transfusions have led to a new acceleration in patients' and physicians' demands for autologous transfusions and more efficient blood conservation techniques. Specific surgical protocols, based on the preoperative administration of r-HuEPO, preoperative autologous blood donation, acute preoperative normovolemic hemodilution and intraoperative blood salvage techniques, have been designed by pediatric neurosurgeons to minimize the exposure of patients affected by craniosynostoses to allogeneic blood and blood components even when the surgical procedure is to be realized at an early age. In spite of the evolution expected in this area in the immediate future, the implementation of these blood concentration methodologies may prove to be highly effective only when associated with a concerned attitude of the surgeon toward blood-sparing intraoperative strategies.
authors.affiliation: Institute of Neurosurgery, Section of Pediatric Neurosurgery, Catholic University Medical School, Largo A. Gemelli, 8, I-00168 Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Velardi
authors.forename: A
authors.initials: A
authors.lastname: Di Chirico
authors.forename: C
authors.initials: C
authors.lastname: Di Rocco
mesh_terms: D001802:Blood Substitutes / Q000266:history; D001803:Blood Transfusion / Q000266:history* / Q000295:instrumentation / Q000379:methods*; D003398:Craniosynostoses / Q000097:blood / Q000266:history* / Q000601:surgery*; D049673:History, 20th Century; D006801:Humans; D007430:Intraoperative Care / Q000266:history* / Q000295:instrumentation / Q000379:methods*; D019635:Neurosurgical Procedures / Q000266:history* / Q000295:instrumentation / Q000379:methods*
chemical_list: D001802:Blood Substitutes