HIV disease-related neutropenia: an independent risk factor for severe infections.
An increasing number of clinical studies have been reported in which neutropenia has been identified as an important independent risk factor in the development of infectious complications in patients with HIV and AIDS. Information on the clinical significance of infecting pathogens and the causes of neutropenia within different patient groups will be discussed, and may have clinical implications in subsequent disease management in these groups. Although the use of highly active antiretroviral therapy has shown some promise in the treatment of HIV-associated hematologic disturbances and immune dysfunction, the rate of virological failure with this treatment over time suggests that these disturbances could reappear in the near future, as well as their associated infectious complications.
Hermans
P
P
Department of Internal Medicine, CHU Saint-Pierre, Brussels, Belgium. crmiclum@ulb.ac.be
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D001424:Bacterial Infections / Q000209:etiology* / Q000517:prevention & control; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D015497:HIV-1; D006801:Humans; D009181:Mycoses / Q000209:etiology* / Q000517:prevention & control; D009503:Neutropenia / Q000209:etiology*; D011994:Recombinant Proteins; D012307:Risk Factors
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000069585:Filgrastim