title: Relative risk of dysplasia for patients with intestinal metaplasia in the distal oesophagus and in the gastric cardia.
abstract: BACKGROUND
  Biopsy specimens obtained from the gastro-oesophageal junction can reveal intestinal metaplasia in patients presenting for routine upper endoscopy. The site of biopsy may play a critical role in determining the dysplasia risk of a patient.
  
  
  OBJECTIVE
  To evaluate prospectively the dysplasia risk in patients with intestinal metaplasia of the distal oesophagus or within the gastric cardia.
  
  
  METHODS
  Patients with short segment Barrett's oesophagus (SSBO) and cardia intestinal metaplasia (CIM) were followed prospectively.
  
  
  RESULTS
  177 patients with SSBO were identified (mean age 62 years, range 38-82; 91% whites). Twenty prevalence cases of dysplasia in SSBO were detected: 17 low grade dysplasia (LGD), three high grade dysplasia (HGD). Seventy six patients with CIM were identified (mean age 67 years, range 37-81; 81% whites). A single prevalence case of LGD in CIM was detected. During follow up of 78 SSBO and 34 CIM patients, dysplasia developed in nine (seven LGD, two HGD) with SSBO and in one (LGD) with CIM. There were significant differences between the two groups with respect to age, ethnicity, dysplasia prevalence, and incidence. Time to dysplasia progression was significantly longer in CIM compared with SSBO patients. Of the five patients with SSBO and HGD, one developed adenocarcinoma of the oesophagus on follow up. No HGD or cancers have been detected over this time period in CIM patients.
  
  
  CONCLUSIONS
  The dysplasia risk is significantly greater in SSBO than in CIM patients, indicating two potentially different clinical processes. Future studies should separate SSBO from CIM in order to enhance the understanding of the pathophysiology and malignant potential of each entity.
authors.affiliation: Division of Gastroenterology, University of Kansas, VA Medical Center, Kansas City, Missouri 64128, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: A P
authors.initials: AP
authors.lastname: Weston
authors.forename: T
authors.initials: T
authors.lastname: Morales
authors.forename: M
authors.initials: M
authors.lastname: Topalovski
authors.forename: M S
authors.initials: MS
authors.lastname: Mayo
authors.forename: R E
authors.initials: RE
authors.lastname: Sampliner
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001471:Barrett Esophagus / Q000150:complications*; D001706:Biopsy; D002299:Cardia / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000150:complications; D008875:Middle Aged; D011230:Precancerous Conditions / Q000209:etiology*; D011446:Prospective Studies; D018570:Risk Assessment; D013274:Stomach Neoplasms / Q000209:etiology*