title: The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice.
abstract: The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.
authors.affiliation: Department of Oral Bacteriology, Nagasaki University School of Dentistry, Sakamoto 1-7-1, Nagasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Naito
authors.forename: M
authors.initials: M
authors.lastname: Matsuoka
authors.forename: N
authors.initials: N
authors.lastname: Ohara
authors.forename: H
authors.initials: H
authors.lastname: Nomaguchi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007371:Interferon-gamma / Q000096:biosynthesis; D007918:Leprosy / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009166:Mycobacterium leprae / Q000276:immunology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; C065036:antigen 85, Mycobacterium bovis; D007371:Interferon-gamma