title: Stereoselective Mukaiyama-Michael/Michael/Aldol Domino Cyclization as the Key Step in the Synthesis of Pentasubstituted Arenes: An Efficient Access to Highly Active Inhibitors of Cholesteryl Ester Transfer Protein (CETP).
abstract: Seemingly heartbreaking for a stereochemist, the one-step selective construction of a stereopentad and its prompt destruction by aromatization has been proven to be an efficient strategy for the synthesis of fivefold substituted, pharmacologically highly active arenes (see scheme).
authors.affiliation: Bayer AG, Pharmaforschung, PH-R-CF Chemisch-wissenschaftliches Laboratorium, D-42096 Wuppertal (Germany).
authors.initials: H
authors.lastname: Paulsen
authors.initials: S
authors.lastname: Antons
authors.initials: A
authors.lastname: Brandes
authors.initials: M
authors.lastname: Lögers
authors.initials: SN
authors.lastname: Müller
authors.initials: P
authors.lastname: Naab
authors.initials: C
authors.lastname: Schmeck
authors.initials: S
authors.lastname: Schneider
authors.initials: J
authors.lastname: Stoltefuß