HOX Pro: a specialized database for clusters and networks of homeobox genes.
It is now clear that the homeobox motif is well conserved across metazoan phyla. It has been established experimentally that a subset of genes containing this motif plays key roles in the orchestration of gene expression during development. Auto- and cross-regulatory functional interactions join homeobox genes into genetic networks. We have developed a specialized database HOX-Pro in order to arrange all available data on structure, function, phylogeny and evolution of Hox genes, Hox clusters and Hox networks. Its primary location is http://www.iephb.nw.ru/hoxpro. The database is also mirrored at http://www.mssm.edu/molbio/hoxpro. The HOX-Pro database is aimed at: (i) analysis and classification of regulatory and coding regions in diverse homeobox and related genes; (ii) comparative analysis of organization of 'Hox-based' genetic networks in the sea urchin Strongylocentrotus purpuratus, the fruit fly Drosophila melanogaster and the mouse Mus musculus; and (iii) analysis of phylogeny and evolution of homeobox genes and clusters.
Spirov
A V
AV
The Sechenov Institute of Evolutionary Physiology, Russian Academy of Sciences, 44 Thorez Avenue, St Petersburg 194223, Russia.
Bowler
T
T
Reinitz
J
J
D000818:Animals; D016208:Databases, Factual; D005786:Gene Expression Regulation / Q000235:genetics; D005801:Genes, Homeobox; D051379:Mice; D005810:Multigene Family; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic / Q000235:genetics