Diffusion-weighted MRI in cyclosporin A neurotoxicity for the classification of cerebral edema.
Cyclosporin A, an immunosuppressive agent, is known to have neurotoxic effects, but until now, there has not been agreement on the underlying mechanism. Our report suggests, by using diffusion-weighted MRI, that the brain lesions caused by cyclosporin A, are probably related to vasogenic edema. This may explain the complete recovery of the lesions on imaging when cyclosporine therapy is stopped.
Debaere
C
C
Department of Radiology, Academic Hospital, Vrije Universiteit Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium.
Stadnik
T
T
De Maeseneer
M
M
Osteaux
M
M
D000328:Adult; D016026:Bone Marrow Transplantation; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D001929:Brain Edema / Q000139:chemically induced / Q000145:classification* / Q000175:diagnosis; D016572:Cyclosporine / Q000009:adverse effects*; D004058:Diffusion; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy
D007166:Immunosuppressive Agents; D016572:Cyclosporine