BDNF atelocollagen mini-pellet accelerates facial nerve regeneration.
We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration.
Kohmura
E
E
Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 E6 Yamadaoka, Suita, Japan. ekohmura@nsurg.med.osaka-u.ac.jp
Yuguchi
T
T
Yoshimine
T
T
Fujinaka
T
T
Koseki
N
N
Sano
A
A
Kishino
A
A
Nakayama
C
C
Sakaki
T
T
Nonaka
M
M
Takemoto
O
O
Hayakawa
T
T
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D003094:Collagen; D004337:Drug Carriers; D005154:Facial Nerve / Q000187:drug effects / Q000502:physiology*; D005158:Facial Paralysis; D005260:Female; D019922:GAP-43 Protein / Q000235:genetics*; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic / Q000187:drug effects*
D019208:Brain-Derived Neurotrophic Factor; D004337:Drug Carriers; D019922:GAP-43 Protein; D012333:RNA, Messenger; C059821:atelocollagen; D003094:Collagen