Primary antiphospholipid syndrome associated with pernicious anaemia.
OBJECTIVE
To determine whether there is an association between pernicious anaemia and antiphospholipid antibody syndrome.


METHODS
Fifteen patients with pernicious anaemia and 11 patients with iron deficiency anaemia (controls) were evaluated for clinical parameters of thrombosis and/or the presence of antiphospholipid antibodies, antinuclear antibodies or lupus anticoagulant.


RESULTS
One asymptomatic patient with pernicious anaemia had laboratory features suggestive of the antiphospholipid syndrome. An additional three patients in each group had slightly elevated antiphospholipid antibody concentrations, within one standard deviation of the normal range.


CONCLUSIONS
The association between pernicious anaemia and antiphospholipid antibody syndrome is rare and evaluation should be guided by clinical indications.
Elis
A
A
Department of Medicine, Meir Hospital, Kfar Saba and Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Savin
H
H
Manor
Y
Y
Kitay
Y
Y
Lishner
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000752:Anemia, Pernicious / Q000453:epidemiology* / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000453:epidemiology* / Q000276:immunology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D017152:Antibodies, Antiphospholipid