title: Antibiotic prophylaxis post-tonsillectomy: is it of benefit?
abstract: The decision to prescribe antibiotics post-tonsillectomy still remains controversial. However, recent changing trends in the tonsillar tissue microflora have been widely reported, with Haemophilus influenzae, Staphylococcus aureus and anaerobic organisms all being implicated. All of the above are beta-lactamase producers and thus render lactamase prone antibiotics inactive. We compared two groups of children, one on Amoxycillin and clavulanic acid (a lactamase stable antibiotic with anaerobic cover) for 1 week post tonsillectomy--Group A (N = 44), and another group on no treatment--Group B (N = 34). We compared tonsillar core, surface and postoperative tonsillar fossae bacteriological profiles in the two groups. The tonsil core pathogens included H. influenzae (64%) of which 9.5% were beta-lactamase producers, Streptococcus viridans (55.9%), S. aureus (37%) of which 86% were beta-lactamase producers, and anaerobes which were found in 25% of samples. We found that there was considerably less morbidity in those children receiving postoperative antibiotics compared to those who did not, as judged by the amount of analgesia consumed (p = 0.379), time to resumption of normal diet (p = 0.0072) and pain analogue scores (p = 0.0006). We feel that treating children who have undergone tonsillectomy with amoxycillin and clavulanic acid significantly reduces postoperative morbidity.
authors.affiliation: Department of Paediatric Otolaryngology, The Children's Hospital, Dublin, Ireland. mcolreavy@hotmail.com
authors.forename: M P
authors.initials: MP
authors.lastname: Colreavy
authors.forename: D
authors.initials: D
authors.lastname: Nanan
authors.forename: M
authors.initials: M
authors.lastname: Benamer
authors.forename: M
authors.initials: M
authors.lastname: Donnelly
authors.forename: A W
authors.initials: AW
authors.lastname: Blaney
authors.forename: T P
authors.initials: TP
authors.lastname: O'Dwyer
authors.forename: M
authors.initials: M
authors.lastname: Cafferkey
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D001424:Bacterial Infections / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D019818:Clavulanic Acid / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D010406:Penicillins / Q000627:therapeutic use*; D011182:Postoperative Care; D011446:Prospective Studies; D014068:Tonsillectomy / Q000379:methods*; D001618:beta-Lactamases / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D019818:Clavulanic Acid; D000658:Amoxicillin; D001618:beta-Lactamases