title: Neural stem cells in the adult human brain.
abstract: New neurons are continuously generated in certain regions of the adult brain. Studies in rodents have shown that new neurons are generated from self-renewing multipotent neural stem cells. Here we demonstrate that both the lateral ventricle wall and the hippocampus of the adult human brain harbor self-renewing cells capable of generating neurons, astrocytes, and oligodendrocytes in vitro, i.e., bona fide neural stem cells.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, SE-171 77, Sweden.
authors.forename: C B
authors.initials: CB
authors.lastname: Johansson
authors.forename: M
authors.initials: M
authors.lastname: Svensson
authors.forename: L
authors.initials: L
authors.lastname: Wallstedt
authors.forename: A M
authors.initials: AM
authors.lastname: Janson
authors.forename: J
authors.initials: J
authors.lastname: Frisén
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018929:Cell Culture Techniques / Q000379:methods*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D002552:Cerebral Ventricles / Q000166:cytology*; D005260:Female; D006624:Hippocampus / Q000166:cytology*; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D013234:Stem Cells / Q000166:cytology* / Q000201:enzymology