title: Epithelial-myoepithelial carcinoma of the parotid. A case of ductal-predominant presentation with cytologic, histologic and ultrastructural correlations.
abstract: BACKGROUND
  The cytologic features of the usual type of epithelial-myoepithelial carcinoma (EMC) of the parotid, with myoepithelial cell predominance, is well described in the cytology literature. In contrast, the cytologic features of ductal-predominant-type EMC has not yet been reported.
  
  
  METHODS
  An 82-year-old male presented with a 2.7-cm parotid mass of two years' duration. Fine needle aspiration smears stained with Diff-Quik showed cohesive tissue fragments outlined by metachromatic fibrils scattered in abundant, smooth, bluish background material. Ultrafast Papanicolaou stain revealed sharply outlined, large ductal cells with smooth, round to oval nuclei, prominent nucleoli and abundant vacuolated cytoplasm; the cells were arranged tridimensionally in occasional follicles that contained thick secretions. Neoplastic myoepithelial cells were occasionally seen at the periphery of tissue fragments, most commonly hidden underneath the neoplastic ductal epithelium at a slightly different focal plane; the cells had small, oval, dark nuclei and inconspicuous cell borders. The nuclear area and cell size of the neoplastic ductal cells was two and three times, respectively, that of neoplastic myoepithelial cells.
  
  
  CONCLUSIONS
  EMC, depending on the ratio of ductal to myoepithelial cell components, has different cytologic presentations. This case illustrates the ductal-predominant presentation of EMC.
authors.affiliation: Department of Pathology, New York University Medical Center, New York 10016, USA. grace.yang@nyu.edu
authors.forename: G C
authors.initials: GC
authors.lastname: Yang
authors.forename: R A
authors.initials: RA
authors.lastname: Soslow
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000648:ultrastructure; D003581:Cytodiagnosis; D006652:Histological Techniques; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010307:Parotid Neoplasms / Q000473:pathology* / Q000648:ultrastructure