Usefulness of procalcitonin in Pseudomonas burn wound sepsis model.
Procalcitonin (PCT), a precursor of calcitonin, and endotoxin were determined in the burn wound sepsis model in which 21 Sprague-Dawley rats were scalded approximately 30% on their back. On day 2 post burn, the wounds were inoculated 1 x 10(8) colony-forming units of Pseudomonas aeruginosa. On day 5 post burn P. aeruginosa was detected by blood culture in 10 of the 21 rats (47.6%). The mortality rate 7 days after burn was 90.5%. Significant correlations were observed between serum endotoxin levels and serum PCT levels on day 5 post burn (r = 0.860, p<0.001). It was suggested that endotoxin may induce the release of PCT and that measuring the levels of PCT may be useful in diagnosing burn wound sepsis.
Nakae
H
H
Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Japan. nakaeh@doc.med.akita-u.ac.jp
Inaba
H
H
Endo
S
S
D000818:Animals; D015415:Biomarkers; D002056:Burns / Q000378:metabolism*; D002116:Calcitonin / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D011498:Protein Precursors / Q000378:metabolism*; D011552:Pseudomonas Infections / Q000378:metabolism*; D011550:Pseudomonas aeruginosa; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000378:metabolism*; D014946:Wound Infection / Q000378:metabolism*
D015415:Biomarkers; C000606589:CALCA protein, human; C000606591:Calca protein, rat; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide