WEREWOLF, a MYB-related protein in Arabidopsis, is a position-dependent regulator of epidermal cell patterning.
The formation of the root epidermis of Arabidopsis provides a simple and elegant model for the analysis of cell patterning. A novel gene, WEREWOLF (WER), is described here that is required for position-dependent patterning of the epidermal cell types. The WER gene encodes a MYB-type protein and is preferentially expressed within cells destined to adopt the non-hair fate. Furthermore, WER is shown to regulate the position-dependent expression of the GLABRA2 homeobox gene, to interact with a bHLH protein, and to act in opposition to the CAPRICE MYB. These results suggest a simple model to explain the specification of the two root epidermal cell types, and they provide insight into the molecular mechanisms used to control cell patterning.
Lee
M M
MM
Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
Schiefelbein
J
J
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins; D019070:Cell Lineage; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics*; D018506:Gene Expression Regulation, Plant; D005801:Genes, Homeobox; D017343:Genes, Plant; D005809:Genes, Regulator; D018398:Homeodomain Proteins / Q000096:biosynthesis; D018546:Hypocotyl / Q000235:genetics / Q000254:growth & development*; D008954:Models, Biological; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000096:biosynthesis / Q000235:genetics*; D018517:Plant Roots / Q000235:genetics / Q000254:growth & development*; D020598:Proto-Oncogene Proteins c-myb; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
C511988:ATR1 protein, Arabidopsis; D029681:Arabidopsis Proteins; C511989:CPC protein, Arabidopsis; D004268:DNA-Binding Proteins; C089991:GL2 protein, Arabidopsis; D018398:Homeodomain Proteins; D010940:Plant Proteins; D020598:Proto-Oncogene Proteins c-myb; C402111:WER protein, Arabidopsis