Spindles get the ran around.
Despite its fundamental role in cell division, the mitotic spindle remains an enigmatic figure in cell biology. This is due to the complex dynamic behaviour of microtubules, which form the spindle fibres responsible for segregating chromosomes to opposite ends of the cell during mitosis. Recent reports indicate that the small GTPase Ran, which plays a key role in nuclear transport, also has a role in mitosis by regulating microtubule nucleation and/or growth. The race is now on to determine how Ran exerts its effects on spindle assembly.
Heald
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Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. heald@socrates.berkeley.edu
Weis
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D000818:Animals; D006801:Humans; D008870:Microtubules; D008938:Mitosis; D008941:Spindle Apparatus; D020931:ran GTP-Binding Protein
D020931:ran GTP-Binding Protein