Microsomal fatty acyl-CoA transacylation and hydrolysis: fatty acyl-CoA species dependent modulation by liver fatty acyl-CoA binding proteins.
arachidonoyl-CoA. In summary, the data established for the first time a role for both L-FABP and ACBP in microsomal phosphatidic acid biosynthesis. By preferentially stimulating microsomal transacylation of unsaturated long chain fatty acyl-CoAs while concomitantly exerting their differential protection from microsomal acyl-CoA hydrolase, L-FABP and ACBP can uniquely function in modulating the pattern of fatty acids esterified to phosphatidic acid, the de novo precursor of phospholipids and triacylglycerols. This may explain in part the simultaneous presence of these proteins in cell types involved in fatty acid absorption and lipoprotein secretion.
Jolly
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Department of Physiology and Pharmacology, Texas A and M University, TVMC, College Station, TX 77843-4466, USA.
Wilton
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Schroeder
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D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D026261:Diazepam Binding Inhibitor; D004789:Enzyme Activation / Q000187:drug effects; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D018996:Myelin P2 Protein / Q000494:pharmacology*; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D010712:Phosphatidic Acids / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley
D000214:Acyl Coenzyme A; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor; C493320:Fabp1 protein, mouse; C493321:Fabp1 protein, rat; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D010712:Phosphatidic Acids; C017585:oleoyl-coenzyme A; D010171:Palmitoyl Coenzyme A; D005992:Glycerol-3-Phosphate O-Acyltransferase