title: Spectrophotometric methods for determining meloxicam in pharmaceuticals using batch and flow-injection procedures.
abstract: Two sensitive and fast spectrophotometric methods using batch and flow-injection procedures for the determination of meloxicam (MX) are proposed. The methods are based on the formation of a green complex between this drug and Fe(III) [2MX/Fe(III)] in a methanolic medium. The calibration graphs resulting from measuring the absorbance at 570 nm are linear over the ranges 2.0-200 and 5.00-250 mg l(-1) with detection limits of 0.47 and 0.72 mg l(-1), respectively. Furthermore, a flow-injection spectrophotometric method involving measurement of the absorbance of the drug at 362 nm in 0.1 M NaOH is presented. The calibration graph is linear over the range 0.5-20 mg l(-1) with a detection limit of 0.04 mg l(-1). The methods are applied to the routine analysis of MX in pharmaceuticals.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain.
authors.forename: M S
authors.initials: MS
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Sánchez-Pedreño
authors.forename: M I
authors.initials: MI
authors.lastname: Albero
authors.forename: J
authors.initials: J
authors.lastname: Martí
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002138:Calibration; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers; D007501:Iron; D000077239:Meloxicam; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods; D013607:Tablets; D013843:Thiazines / Q000032:analysis*; D013844:Thiazoles / Q000032:analysis*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D013607:Tablets; D013843:Thiazines; D013844:Thiazoles; D007501:Iron; D000077239:Meloxicam