Molecular targets of gene therapy.
Ischemic reperfused heart represents a potential target for gene therapy because gene transfer can represent an alternate pharmacological approach to protect the heart from cellular injury. Gene therapy may be particularly useful to deal with previously unapproachable problems. For myocardial preservation, gene therapy could replace those pharmacological interventions when drugs are delivered locally by sustained release with the help of mechanical device, eg, implants. In this review, attempts are made to define the molecular targets for gene therapy primarily applicable to myocardial preservation associated with ischemia and reperfusion. It has been emphasized that for successful gene transfer, not only characterization of proper targets and elimination of undesirable side effects are necessary, but also the therapy must be proven superior compared to other pharmacological interventions including surgery.
Das
D K
DK
Department of Surgery, University of Connecticut School of Medicine, Farmington 06030-1110, USA. ddas@neuron.uchc.edu
Engelman
R M
RM
Maulik
N
N
Rousou
J A
JA
Flack
J E
JE
Deaton
D W
DW
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D017202:Myocardial Ischemia / Q000235:genetics / Q000628:therapy; D015428:Myocardial Reperfusion Injury / Q000235:genetics / Q000628:therapy*; D014161:Transduction, Genetic