title: Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function.
abstract: Airway S-nitrosothiols (SNOs) are naturally occurring bronchodilators. SNOs, nitrate, and nitrite were measured in bronchoalveolar lavage fluid of 23 patients with cystic fibrosis (CF) and mild pulmonary disease (aged 6-16 years) and 13 healthy children (aged 8-15 years). Concentrations of SNOs were decreased in the lower airways of patients with CF and mild pulmonary disease (median, range: 0, 0-320 nmol/L vs 80, 0-970 nmol/L) despite normal levels of the inert nitric oxide metabolites nitrate and nitrite (mean +/- SEM: 3.7 +/- 0.5 micromol/L vs 4.8 +/- 0.9 micromol/L). S-nitrosolation- mediated bioreactivities may be impaired by depletion of the CF airway SNO reservoir.
authors.affiliation: Children's Hospital, University of Essen, Essen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Grasemann
authors.forename: B
authors.initials: B
authors.lastname: Gaston
authors.forename: K
authors.initials: K
authors.lastname: Fang
authors.forename: K
authors.initials: K
authors.lastname: Paul
authors.forename: F
authors.initials: F
authors.lastname: Ratjen
mesh_terms: D000293:Adolescent; D001980:Bronchi / Q000737:chemistry*; D001992:Bronchoalveolar Lavage Fluid; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008623:Mercaptoethanol; D009603:Nitroso Compounds / Q000032:analysis*; D012129:Respiratory Function Tests; D026403:S-Nitrosothiols
chemical_list: D009603:Nitroso Compounds; D026403:S-Nitrosothiols; D008623:Mercaptoethanol; C032635:S-nitrosomercaptoethanol