title: p-Chloroamphetamine (PCA) suppresses ingestive behavior in male rats.
abstract: Ingestive behavior was activated in male rats by intraoral intake and intake from a bottle of 1-M solution of sucrose. Intraperitoneal injection of p-chloroamphetamine (PCA), releasing central 5-hydroxytryptamine (5-HT) from serotonergic nerve terminals, inhibited ingestion of the sucrose solution. Significant inhibition of sucrose intake by PCA was observed at 1.25 and 2.5 mg/kg dose in a bottle intake test, and at 5.0 mg/kg dose in an intraoral intake test. These findings suggested that 1.25 and 5.0 mg/kg of PCA suppressed appetitive ingestive behavior and consummatory ingestive behavior in male rats, respectively.
authors.affiliation: Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
authors.forename: T R
authors.initials: TR
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Aokikomori
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: K W
authors.initials: KW
authors.lastname: Takahashi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018490:Serotonin Agents / Q000494:pharmacology*; D013395:Sucrose / Q000008:administration & dosage; D010133:p-Chloroamphetamine / Q000494:pharmacology*
chemical_list: D018490:Serotonin Agents; D013395:Sucrose; D010133:p-Chloroamphetamine