Failure of pre-diarrheal antibiotics to prevent hemolytic uremic syndrome in serologically proven Escherichia coli O157:H7 gastrointestinal infection.
A girl had hemolytic uremic syndrome after Escherichia coli O157:H7 infection, despite pre-diarrheal administration of an antibiotic that prevented detectable intestinal colonization. This report casts doubt on the advisability of antibiotic therapy for E coli O157:H7 infections and has implications for our understanding of the mechanism of this disorder.
Igarashi
T
T
Department of Pediatrics, The University of Tokyo, Mejirodai Campus, Mejirodai, Bunkyo-ku, Tokyo, Japan.
Inatomi
J
J
Wake
A
A
Takamizawa
M
M
Katayama
H
H
Iwata
T
T
D000328:Adult; D015281:Cefmenoxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000150:complications* / Q000188:drug therapy*; D019453:Escherichia coli O157; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D013997:Time Factors; D017211:Treatment Failure
D002511:Cephalosporins; C046817:cefteram pivoxil; D015281:Cefmenoxime