title: Sex differences in the inferior parietal lobule.
abstract: The inferior parietal lobule (IPL) - a neocortical region and part of the heteromodal association cortex (HASC) - has been hypothesized to exhibit sexual dimorphism, as do other HASC regions, particularly with regard to asymmetry. Using a reliable method for measuring IPL gray matter volume based upon individual sulcal-gyral landmarks, we measured this region on magnetic resonance imaging scans from a sample of 15 individually matched pairs of normal male and female subjects. Male subjects showed significantly larger left, but not right, IPL volumes when compared to females. Males also showed a leftward (left > right) asymmetry for the IPL, with a less marked opposite asymmetry in females. Such sexual dimorphisms may possibly underlie the subtle cognitive differences observed between the sexes.
authors.affiliation: Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Frederikse
authors.forename: A
authors.initials: A
authors.lastname: Lu
authors.forename: E
authors.initials: E
authors.lastname: Aylward
authors.forename: P
authors.initials: P
authors.lastname: Barta
authors.forename: G
authors.initials: G
authors.lastname: Pearlson
mesh_terms: D000328:Adult; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000033:anatomy & histology*; D012737:Sex Factors