Normal hepatic growth: study of the proliferative capacity and apoptosis of the normal liver during childhood.
We explored the mechanism of normal hepatic growth in children by evaluating the proliferation index (with Ki-67 antibody) and apoptosis index (with the ApopTag kit). The proliferative index is almost constant, but the level of apoptosis is very low in childhood and increases with age. Thus the growth of the liver in children is not due to a high proliferation index, but to a very low apoptosis index.
Gheban
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Pathology Department, University of Medicine and Pharmacy, Str. Peana nr. 18, bl. V6, ap. 4, 3400 Cluj-Napoca, Romania.
D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002455:Cell Division; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000254:growth & development*; D008297:Male; D012016:Reference Values