title: Maturation of bladder reflex pathways during postnatal development.
abstract: Neuroanatomical and electrophysiological techniques have provided new insights into the organization of the spinal cord circuitry and the neurotransmitter mechanisms involved in primitive voiding reflexes in neonatal animals. In addition, studies of unitary synaptic transmission in spinal cord slice preparations indicate that developmental and spinal cord injury induced plasticity in sacral parasympathetic reflex pathways is due in part to alterations in glutamatergic excitatory transmission between interneurons and parasympathetic preganglionic neurons. It is proposed that these synaptic changes are due to competition between segmental and supraspinal inputs. Thus synaptic remodeling in the sacral parasympathetic nucleus is likely to be an important factor in the postnatal maturation of voiding reflexes.
authors.affiliation: Department of Pharmacology, Medical School, University of Pittsburgh, Pennsylvania 15261, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: de Groat
authors.forename: I
authors.initials: I
authors.lastname: Araki
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D006801:Humans; D012018:Reflex; D013116:Spinal Cord / Q000254:growth & development / Q000502:physiology*; D001743:Urinary Bladder / Q000254:growth & development / Q000294:innervation / Q000502:physiology*; D014554:Urination