[Comparative genomic hybridization analysis of primary gastric carcinomas].
OBJECTIVE
To investigate whether unknown genes are involved in the tumorigenesis of gastric cancer.


METHODS
Fourty-three primary gastric carcinomas were analyzed by comparative genomic hybridization(CGH).


RESULTS
A gain in chromosome 3p(8/43), 8q(8/43), 20[20(9/43), 20p(7/43), 20q(4/43)], 12q (16/43), and 13q(12/43) was observed while a loss of 19[19(15/43), 19p (13/43)], 17[17(8/43), 17p(10/43)], 16(10/43) and 1p(11/43) was discovered.


CONCLUSIONS
There were characteristic changes in 3p, 8q, 20, 12q, 13q, 19, 17, 16, and 1p in gastric carcinoma, and some unknown genes located in the above regions might be of importance to gastric carcinoma pathogenesis.
Fu
S
S
Laboratory of Medical Genetics, Harbin Medical University, Harbin 150086, P.R.China. Fusb@ems.hrbmu.edu.cn
Wang
B
B
Guan
X
X
Xia
J
J
Lu
S
S
Zhang
G
G
Li
P
P
D002869:Chromosome Aberrations; D009693:Nucleic Acid Hybridization; D013274:Stomach Neoplasms / Q000235:genetics*