Sex differences in long-term consequences of prenatal diazepam exposure: possible underlying mechanisms.
Prenatal exposure to diazepam, a benzodiazepine (BZD) compound, leads to pronounced effects on responses to stressors in exposed animals when they reach adulthood. Many of the responses are sex specific. The mechanisms mediating the effects of the exposure on the organism have not been elucidated; however, the time course for the appearance of altered function following in utero drug exposure indicates that the exposure interfered with neural organization of mechanisms mediating responses to stressors. The article discusses possible mechanisms that relate to sites of action of the drug in the developing brain: the GABA(A) receptor, and the mitochondrial BZD receptor. The mechanisms mediating the sex-specific impact of diazepam on the developing brain appear to be complex and interactive.
Kellogg
C K
CK
Department of Brain and Cognitive Sciences, University of Rochester, NY 14627, USA. kellogg@bcs.rochester.edu
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000196:embryology; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D018757:GABA Modulators / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D012727:Sex Characteristics; D012741:Sexual Maturation / Q000187:drug effects; D013997:Time Factors
D018757:GABA Modulators; D011963:Receptors, GABA-A; D003975:Diazepam