title: Platelet function in dogs treated for lymphoma and hemangiosarcoma and supplemented with dietary n-3 fatty acids.
abstract: A prospective randomized, double-blind clinical trial was performed to test the hypothesis that dogs with malignancies that are supplemented with n-3 fatty acids do not have clinical or laboratory evidence of coagulation disorders or altered platelet function when compared with unsupplemented dogs with similar malignancies. Thirteen dogs with hemangiosarcoma and 66 dogs with lymphoma were evaluated. Coagulation status of the dogs with lymphoma and hemangiosarcoma was evaluated with prothrombin time, partial thromboplastin time, platelet count, and in vitro platelet aggregometry using the whole-blood method. These tests were performed at 5 time points: before beginning the diet (week 0), at weeks 3, 15, and 21, and at 1 year or when progressive disease was evident. Alterations in platelet function in dogs receiving a diet supplemented with dietary n-3 fatty acids were not identified when compared to dogs fed a control diet. Dietary n-3 fatty acid supplementation using this dosage and ratio in dogs with lymphoma or hemangiosarcoma did not induce clinically significant hemorrhage in these animals. Therefore, supplementation with n-3 fatty acids did not result in clinical or laboratory evidence relating to uncontrolled hemorrhage in these dogs.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: McNiel
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: C
authors.initials: C
authors.lastname: Mallinckrodt
authors.forename: K
authors.initials: K
authors.lastname: Richardson
authors.forename: M J
authors.initials: MJ
authors.lastname: Fettman
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000662:veterinary*; D001792:Blood Platelets / Q000502:physiology*; D004032:Diet; D004285:Dogs; D004311:Double-Blind Method; D005227:Fatty Acids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006394:Hemangiosarcoma / Q000188:drug therapy / Q000662:veterinary*; D006470:Hemorrhage / Q000209:etiology / Q000662:veterinary; D008223:Lymphoma / Q000188:drug therapy / Q000662:veterinary*; D010979:Platelet Function Tests; D011446:Prospective Studies
chemical_list: D005227:Fatty Acids