title: [The objective of acute stroke therapy and neuroprotective therapeutic approaches].
abstract: In this article we review the concept of ischemic penumbra and emphasize the potentially reversible aspect as a function of time, which is the basis of the concept of a therapeutic window. Also, we briefly consider the physiopathology of the ischemic cascade, emphasizing the levels at which the different neuroprotector drugs under investigation have their effect.
authors.affiliation: University of Massachusetts Medical Center, Worcester 01605-2982, USA.
authors.forename: M
authors.initials: M
authors.lastname: Fisher
mesh_terms: D000208:Acute Disease; D001921:Brain / Q000098:blood supply* / Q000187:drug effects*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D018696:Neuroprotective Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents
vernacular_title: El objetivo del tratamiento en la enfermedad cerebrovascular aguda y los enfoques terapéuticos neuroprotectores.