Influencing of spatial memory in rats by DSP-4 and mescaline.
Behavioural effects of two experimental neurotoxins, mescaline and DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), on retention of spatial orientation were studied in the T-maze. The stereotaxic administration of both neurotoxins into the selected brain structures was chosen to reveal this effect. The intensity and time course of the neurotoxic effect were dependent on the brain area administered. Nevertheless, the lengthening of the latencies in reaching the goal was generally more marked after mescaline in comparison with DSP-4.
Koupilová
M
M
Purkynĕ Military Medical Academy, Hradec Králové. koupilova@pmfhk.cz
Herink
J
J
Krs
O
O
D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008635:Mescaline / Q000494:pharmacology*; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D001596:Benzylamines; D006213:Hallucinogens; D009498:Neurotoxins; C012102:DSP 4; D008635:Mescaline