Expression analysis of 21 transcripts physically anchored within the chromosomal region 10q24.
Chromosome band 10q24 harbors the critical regions for inherited neurological disorders such as partial epilepsy (EPT), urofacial syndrome, and a distinct form of spastic paraparesis. To facilitate the selection of candidate genes for these diseases, we determined the mRNA sizes and analyzed the expression patterns of 21 brain transcripts defined by expressed sequence tags previously localized along a 7.4-Mb interval of 10q24. In addition to a number of widely expressed transcribed sequences, we identified several transcripts exclusively or predominantly expressed in the brain, which represent potential candidates for the neurological diseases associated with this genomic region.
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Istituto di Genetica Molecolare del CNR, Alghero, 07041, Italy. cn@igm.ss.cnr.it
Pitzalis
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D000015:Abnormalities, Multiple / Q000235:genetics; D015152:Blotting, Northern; D025063:Chromosome Disorders / Q000235:genetics*; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D004828:Epilepsies, Partial / Q000235:genetics; D020224:Expressed Sequence Tags; D005145:Face / Q000002:abnormalities; D005786:Gene Expression Regulation; D006801:Humans; D020336:Paraparesis, Spastic / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013577:Syndrome; D014158:Transcription, Genetic; D014551:Urinary Tract / Q000002:abnormalities
D018076:DNA, Complementary; D012333:RNA, Messenger