title: Association and linkage analysis of ICD-10 diagnosis for alcoholism.
abstract: We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.
authors.affiliation: Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, OH 44109, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Tiwari
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: Y
authors.initials: Y
authors.lastname: Shu
authors.forename: V
authors.initials: V
authors.lastname: George
mesh_terms: D000437:Alcoholism / Q000145:classification* / Q000175:diagnosis / Q000235:genetics*; D000483:Alleles; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D016014:Linear Models; D019655:Quantitative Trait, Heritable
chemical_list: D005819:Genetic Markers