Oral administration of soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) reduces ischemic damage in the gerbil hippocampus.
Mongolian gerbils orally administered with soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS, 240 mg/kg) for 5 days were subjected to cerebral ischemia by bilateral common carotid artery occlusion. The pyramidal cell damage of the hippocampal CA1 subfield was classified into 4 grades according to the proportion of damaged neurons on the tenth day after the ischemic treatment. The damage score of the SB-tPS group was statistically less than that of the control group. This suggests that the pre-administration of SB-tPS may relieve the delayed neuronal cell death caused by cerebral ischemia.
Suzuki
S
S
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
Furushiro
M
M
Takahashi
M
M
Sakai
M
M
Kudo
S
S
D000284:Administration, Oral; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D009336:Necrosis; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010718:Phosphatidylserines / Q000627:therapeutic use*; D017966:Pyramidal Cells / Q000473:pathology
D018696:Neuroprotective Agents; D010718:Phosphatidylserines