Potential role of CCR5 polymorphism in the development of AIDS dementia complex.
The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (DeltaCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of DeltaCCR5 in in vitro as well as in vivo studies. We provide data that suggest that CCR5 polymorphism may affect the onset of AIDS dementia complex in vivo and data that show that HIV-1 replication is influenced by the DeltaCCR5 allele in vitro. Knowing the CCR5 genotype of an individual will help to better interpret research results and may even provide new information about mechanisms of disease.
Boven
L A
LA
Eijkman-Winkler Institute for Microbiology, Infectious Diseases and Inflammation, section NeuroImmunology, AZU, room G04.614, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. l.a.boven@lab.azu.nl
van der Bruggen
T
T
van Asbeck
B S
BS
Marx
J J
JJ
Nottet
H S
HS
D015526:AIDS Dementia Complex / Q000209:etiology* / Q000235:genetics / Q000821:virology; D015696:Gene Products, tat / Q000378:metabolism; D005838:Genotype; D015497:HIV-1 / Q000502:physiology*; D006579:Heterozygote; D006801:Humans; D008264:Macrophages / Q000821:virology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000032:analysis; D019713:Receptors, CCR5 / Q000235:genetics*; D014779:Virus Replication; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D012367:RNA, Viral; D019713:Receptors, CCR5; D054322:tat Gene Products, Human Immunodeficiency Virus