title: Synapse structure: glutamate receptors connected by the shanks.
abstract: A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.
authors.affiliation: Department of Neurobiology, Duke University Medical Center, Durham, 27710, USA. ehlers@neuro.duke.edu
authors.forename: M D
authors.initials: MD
authors.lastname: Ehlers
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D051356:Cortactin; D000072233:Homer Scaffolding Proteins; D006801:Humans; D046911:Macromolecular Substances; D008840:Microfilament Proteins / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009479:Neuropeptides / Q000737:chemistry / Q000502:physiology; D017434:Protein Structure, Tertiary; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry* / Q000502:physiology; D000074407:SAP90-PSD95 Associated Proteins; D015398:Signal Transduction; D013569:Synapses / Q000737:chemistry* / Q000648:ultrastructure; D020798:Two-Hybrid System Techniques
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D051356:Cortactin; D000072233:Homer Scaffolding Proteins; D046911:Macromolecular Substances; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D000074407:SAP90-PSD95 Associated Proteins; C122162:SHANK2 protein, human; C492357:SHANK3 protein, human; C120531:Shank1 protein, rat; C485686:Shank2 protein, rat; C033652:postsynaptic density proteins