In vitro activities of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pediococcus isolates.
Testing of susceptibility to 13 antibiotics was performed with 90 isolates of Lactobacillus, Leuconostoc, and Pediococcus. MICs at which 90% of the isolates tested were inhibited by HMR3647, erythromycin, and ciprofloxacin were 0.015, 0.125 and 32 microg/ml, respectively. The penicillin MIC was > or = 16 microg/ml against 26.2% of the studied Lactobacillus sp. isolates and 50% of Lactobacillus plantarum. HMR3647 showed excellent activity against these genera.
Zarazaga
M
M
Area Bioquímica y Biología Molecular, Universidad de la Rioja, 26004 Logroño, Spain.
Sáenz
Y
Y
Portillo
A
A
Tenorio
C
C
Ruiz-Larrea
F
F
Del Campo
R
R
Baquero
F
F
Torres
C
C
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D048628:Ketolides; D007778:Lactobacillus / Q000187:drug effects* / Q000235:genetics; D007934:Leuconostoc / Q000187:drug effects* / Q000235:genetics; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D010376:Pediococcus / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D048628:Ketolides; D018942:Macrolides; D002939:Ciprofloxacin; D004917:Erythromycin; C106791:telithromycin