title: MitoNuc and MitoAln: two related databases of nuclear genes coding for mitochondrial proteins.
abstract: Mitochondria, besides their central role in energy metabolism, have recently been found to be involved in a number of basic processes of cell life and to contribute to the pathogenesis of many degenerative diseases. All functions of mitochondria depend on the interaction of nuclear and organellar genomes. Mitochondrial genomes have been extensively sequenced and analysed and the data collected in several specialised databases. In order to collect information on nuclear coded mitochondrial proteins we developed MitoNuc and MitoAln, two related databases containing, respectively, detailed information on sequenced nuclear genes coding for mitochondrial proteins in Metazoa and yeast, and the multiple alignments of the relevant homologous protein coding regions. MitoNuc and MitoAln retrieval through SRS at http://bio-www.ba.cnr.it:8000/srs6/ can easily allow the extraction of sequence data, subsequences defined by specific features and nucleotide or amino acid multiple alignments.
authors.affiliation: Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, 20122 Milano, Italy. graziano.pesole@unimi.it
authors.forename: G
authors.initials: G
authors.lastname: Pesole
authors.forename: C
authors.initials: C
authors.lastname: Gissi
authors.forename: D
authors.initials: D
authors.lastname: Catalano
authors.forename: G
authors.initials: G
authors.lastname: Grillo
authors.forename: F
authors.initials: F
authors.lastname: Licciulli
authors.forename: S
authors.initials: S
authors.lastname: Liuni
authors.forename: M
authors.initials: M
authors.lastname: Attimonelli
authors.forename: C
authors.initials: C
authors.lastname: Saccone
mesh_terms: D016208:Databases, Factual; D016247:Information Storage and Retrieval; D008928:Mitochondria / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D009687:Nuclear Proteins