title: Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy.
abstract: We report a rare case of malignant chondroblastoma, which presented in a 47-year-old man as a recurrent tumor, 18 years following wide excision of a typical pelvic chondroblastoma. Radiologic studies of the recurrent tumor showed a large, lytic, destructive lesion of the right pelvic bones and femur, with a pathologic fracture of the latter, a large pelvic soft tissue mass, and multiple pulmonary metastases. Biopsy tissue showed typical features of chondroblastoma, but also increased nuclear atypia, hyperchromasia, and pleomorphism, compared to the original tumor, and, most significantly, abnormal mitotic figures. Immunohistochemical studies of the recurrent tumor revealed p53 mutation and extensive proliferative activity, and flow cytometric studies showed DNA aneuploidy, none of which was present in the original tumor. The patient received chemotherapy and radiation, but died of disease eight months after presentation. We also review chondroblastoma in general, to assign this unusual lesion to a tumor subtype.
authors.affiliation: Department of Pathology and Laboratory Medicine, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas 77030, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Ostrowski
authors.forename: M E
authors.initials: ME
authors.lastname: Johnson
authors.forename: L D
authors.initials: LD
authors.lastname: Truong
authors.forename: M J
authors.initials: MJ
authors.lastname: Hicks
authors.forename: F E
authors.initials: FE
authors.lastname: Smith
authors.forename: H J
authors.initials: HJ
authors.lastname: Spjut
mesh_terms: D000782:Aneuploidy; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D002804:Chondroblastoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy; D004273:DNA, Neoplasm / Q000235:genetics*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D010386:Pelvic Neoplasms / Q000175:diagnosis*; D010388:Pelvis / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D016159:Tumor Suppressor Protein p53