Hepatic veno-occlusive disease.
Hepatic veno-occlusive disease (VOD) after stem cell transplantation is a toxic manifestation of the conditioning regimen most probably emphasized by the allogeneic reaction. Its overall mortality rate is < 4% in adults as well as in children. Recent progress has been achieved in the diagnosis of this complication. However, better methods of both prophylaxis and treatment are needed.
Ribaud
P
P
Federation d'Hematologie, Service de Greffe de Moelle, Hôpital St Louis, Paris, France. patricia.ribaud@chu-stlouis.fr
Gluckman
E
E
D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D015996:Survival Rate; D019172:Transplantation Conditioning / Q000009:adverse effects