title: The importance of watching our weights: how the choice of weights for non-independent sib pairs can dramatically alter results.
abstract: Handling non-independent sib pairs in families with multiple affected sibs presents a problem in likelihood-based nonparametric linkage analyses. We contrast the more stable partial-likelihood solution in MAPMAKER/SIBS with the extremely variable partial-likelihood approach used in ASPEX, and the potential inflation of lods when the problem is ignored as in BETA.
authors.affiliation: Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA.
authors.forename: P
authors.initials: P
authors.lastname: Van Eerdewegh
authors.forename: J
authors.initials: J
authors.lastname: Dupuis
authors.forename: S L
authors.initials: SL
authors.lastname: Santangelo
authors.forename: L B
authors.initials: LB
authors.lastname: Hayward
authors.forename: D
authors.initials: D
authors.lastname: Blacker
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D003198:Computer Simulation; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D015233:Models, Statistical; D009679:Nuclear Family; D012984:Software; D018709:Statistics, Nonparametric