Specific Alkylation of Guanine Opposite to a Single Nucleotide Bulge: A Chemical Probe for the Bulged Structure of DNA.
Remarkable enhancement of guanine alkylation just opposite a bulged site by 13R-1 compared with those in normal duplex DNA is ascribable to the formation of a unique intercalated complex that is attainable only at the bulged sites (see picture). This observation suggests that 13R-1 can be used as a chemical probe for the bulged structure of DNA.
Nakatani
K
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University (and) CREST, Japan Science and Technology Corporation, Kyoto 606-8501 (Japan).
Okamoto
A
Saito
I