Pulse nebulization in pneumatic devices.
Aerosols of a physiological salt solution and aqueous solutions of salbutamol, sodium cromoglicate, and dornase alfa were generated in a pneumatic nebulizer and analyzed in a system with controlled humidity of air as a carrier gas. Mass distribution of aerosol particles and yield of generation for pulse nebulization were measured. Pulsation of generation was realized with an attachment maintained by a computer program. Opening times of the valve were in the range 50-800 ms. The results indicate the possibility of improving aerosol particle delivery to the lung using a pulse generation system.
Gradoń
L
L
Department of Chemical and Process Engineering, Warsaw University of Technology,Poland. gradon@ichip.pw.edu.pl.
Sosnowski
T R
TR
Podolec
Z
Z
D000280:Administration, Inhalation; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics; D003850:Deoxyribonuclease I / Q000008:administration & dosage / Q000493:pharmacokinetics; D005100:Expectorants / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung; D009330:Nebulizers and Vaporizers; D016272:Occupational Health; D010316:Particle Size; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D001993:Bronchodilator Agents; D005100:Expectorants; D011994:Recombinant Proteins; C085693:DNASE1 protein, human; D003850:Deoxyribonuclease I; D004205:Cromolyn Sodium; D000420:Albuterol