title: [Buprenorphine and pregnancy. Analysis of 24 cases].
abstract: BACKGROUND
  Maintenance therapy of drug-addict mothers with medical and psychosocial support may reduce complications (prematurity, growth retardation, fetal distress and fetal death). Methadone has been widely used during pregnancy with beneficial effects. Buprenorphine (BUP) is used more and more and shows the same beneficial effects.
  
  
  METHODS
  Twenty-four pregnant women received BUP and their infants were enrolled in the study. Thirteen retrospective (GI) and 11 prospective (GII) cases were studied. In the GII, the women were treated and followed up in an interdisciplinary manner.
  
  
  RESULTS
  Complications in GII were less frequent than in GI: 9 vs 30% of prematurity, 9 vs 46% of fetal growth retardation and 0 vs 23% of acute fetal distress. However, the frequency of withdrawal syndrome was the same in both groups, 63 vs 69%, though improvements came more rapidly in GII.
  
  
  CONCLUSIONS
  This study shows that the use of BUP during pregnancy, combined with medical and psychosocial support, may reduce addiction complications. This support has to be maintained after the birth.
authors.affiliation: Service de pédiatrie II, hôpital Central, Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Jernite
authors.forename: B
authors.initials: B
authors.lastname: Viville
authors.forename: B
authors.initials: B
authors.lastname: Escande
authors.forename: J P
authors.initials: JP
authors.lastname: Brettes
authors.forename: J
authors.initials: J
authors.lastname: Messer
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009294:Narcotics / Q000494:pharmacology / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control* / Q000523:psychology; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012944:Social Support; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000628:therapy*
chemical_list: D009294:Narcotics; D002047:Buprenorphine
vernacular_title: Grossesse et buprénorphine. A propos de 24 cas.