Effect of stobadine on cardiac injury induced by ischemia and reperfusion.
The aim of this work was to evaluate the effect of the antioxidant stobadine on ischemia/reperfusion-induced injury of the isolated rat heart. Experiments were performed according to Langendorff. Ischemia was induced by stop-flow lasting 30 minutes and the duration of repefusion was 30 minutes. Reperfusion of the ischemic heart induced dysrhythmias, with the most severe ones occurring in the first minutes of reperfusion. A significant increase in coronary perfusion pressure was observed starting after 15 min of reperfusion. Stobadine (10(-6) M applied 3 minutes before onset of ischemia and during reperfusion) prevented the deleterious effects to develop fully. The protective effect of stobadine observed in our experiments seems to be a consequence of its antioxidant properties.
Knezl
V
V
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Sotníková
R
R
Okruhlicová
L
L
Navarová
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D002243:Carbolines / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013318:Stroke Volume / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D002243:Carbolines; D017382:Reactive Oxygen Species; C100106:dicarbine