title: Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered.
abstract: OBJECTIVE
  To examine the effect of single compared with repetitive (at least three) cycles of high-dose cytarabine after induction therapy for patients with acute myeloid leukemia (AML) who have the t(8;21)(q22;q22) karyotype.
  
  
  METHODS
  Patients entered onto the study had AML and t(8;21) and attained a complete remission on four successive Cancer and Leukemia Group B studies. In these studies, either > or = three cycles of high-dose cytarabine or one cycle of high-dose cytarabine was administered, followed by sequential cyclophosphamide/etoposide and mitoxantrone/diaziquone with or without filgrastim support. Outcomes of these two groups of t(8;21) patients were compared.
  
  
  RESULTS
  A total of 50 patients with centrally reviewed AML and t(8;21) were assigned to receive one (n = 29) or > or = three cycles (n = 21) of high-dose cytarabine as postinduction therapy. The clinical features of these two groups of patients were similar. Initial remission duration for t(8;21) patients assigned to one cycle of high-dose cytarabine was significantly inferior (P =.03), with 62% of patients experiencing relapse with a median failure-free survival of 10.5 months, compared with the group of patients who received > or = three cycles, in which only 19% experienced relapse and failure-free survival is estimated to be greater than 35 months. Furthermore, overall survival was also significantly compromised (P =.04) in patients assigned to one cycle of high-dose cytarabine, with 59% having died as a consequence of AML, compared with 24% of those who received > or = three cycles of high-dose cytarabine.
  
  
  CONCLUSIONS
  These data demonstrate that failure-free survival and overall survival of patients with t(8;21)(q22;q22) may be compromised by treatment approaches that do not include sequential high-dose cytarabine therapy.
authors.affiliation: Walter Reed Army Medical Center, Washington, DC 20307, USA. john_c.byrd@wramaa.chcs.amedd.army.mil
authors.forename: J C
authors.initials: JC
authors.lastname: Byrd
authors.forename: R K
authors.initials: RK
authors.lastname: Dodge
authors.forename: A
authors.initials: A
authors.lastname: Carroll
authors.forename: M R
authors.initials: MR
authors.lastname: Baer
authors.forename: C
authors.initials: C
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Stamberg
authors.forename: M
authors.initials: M
authors.lastname: Qumsiyeh
authors.forename: J O
authors.initials: JO
authors.lastname: Moore
authors.forename: R J
authors.initials: RJ
authors.lastname: Mayer
authors.forename: F
authors.initials: F
authors.lastname: Davey
authors.forename: C A
authors.initials: CA
authors.lastname: Schiffer
authors.forename: C D
authors.initials: CD
authors.lastname: Bloomfield
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D003561:Cytarabine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016019:Survival Analysis; D014178:Translocation, Genetic
chemical_list: D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine