New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein.
Serum amyloid P component (SAP) is a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. Although SAP is described to bind many ligands, no clear biological function has been ascribed to it as yet. This review summarizes the current knowledge about the protein SAP, its ligands and functional properties. Finally, the author focuses on the recent finding of the binding of SAP to lipopolysaccharide (LPS) and Gram-negative bacteria and the possible functional consequences of these interactions.
de Haas
C J
CJ
Eijkman-Winkler Institute, Department of Inflammation, G04.614, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
D000818:Animals; D006090:Gram-Negative Bacteria / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000502:physiology*
D008070:Lipopolysaccharides; D000683:Serum Amyloid P-Component