title: Oxidized LDL and expression of monocyte adhesion molecules.
abstract: Accumulation of substantial numbers of monocyte/macrophages, as well as activated T lymphocytes, in focal areas of arterial intima appears to be a hallmark of atherogenesis. Our report demonstrated that lysophosphatidylcholine (lyso-PC), a polar phospholipid component that is increased in atherogenic lipoproteins, such as oxidized LDL and remnants lipoproteins in diabetic and type III hyperlipidemic patients, can upregulate adhesion molecules for monocytes and T lymphocytes, and growth factors, such as heparin-binding epidermal growth factor-like growth factor and PDGF-A and B chains. Recently we identified the novel receptor for oxidized LDL, named Lox-1. Therefore in this paper we summarize the importance of the interaction between oxidized LDL and its receptor, LOX-1 in terms of early stage of atherogenesis.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Japan. tkita@kuhp.kyoto-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kita
authors.forename: N
authors.initials: N
authors.lastname: Kume
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Horiuchi
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Yokode
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood; D008077:Lipoproteins, LDL / Q000494:pharmacology / Q000502:physiology*; D008244:Lysophosphatidylcholines / Q000494:pharmacology; D011973:Receptors, LDL / Q000502:physiology; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E
chemical_list: D015815:Cell Adhesion Molecules; D008077:Lipoproteins, LDL; D008244:Lysophosphatidylcholines; C495137:OLR1 protein, human; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; C099252:oxidized low density lipoprotein