Effect of X-ray contrast media on blood flow properties after coronary angiography.
In vitro studies suggest that ionic and nonionic X-ray contrast media have different effects on rheological parameters. The risk of thrombotic complications in coronary interventions was reported to be lower using ionic contrast media. The aim of the present study was to compare the effects of different types of contrast media on rheological parameters after coronary angiography. Sixty patients were randomized to four groups: ioxaglate 320 (dimeric, ionic, n = 18), iomeprol 400 (monomeric, nonionic, n = 12), iobitridol 350 (monomeric, nonionic, n = 12), and iodixanol 320 (dimeric, nonionic, n = 18). Blood samples were collected via the side port of the arterial sheath immediately before and at the end of coronary angiography. In our study, all types of contrast media caused a significant decrease in haematocrit (Hct), plasma viscosity (PV), erythrocyte aggregation (EA), and in the platelet reactivity index (PRI). The most pronounced decrease in Hct was found using the ionic dimer ioxaglate. There were no significant differences between the contrast media with respect to their effects on PV, EA, and PRI.
Scheller
B
B
Internal Medicine III (Cardiology/Angiology), Saarland University Clinic, Homburg/Saar, Germany. scheller@med-in.uni-sb.de
Hennen
B
B
Thünenkötter
T
T
Mrowietz
C
C
Markwirth
T
T
Schieffer
H
H
Jung
F
F
D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001809:Blood Viscosity / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography; D004492:Edetic Acid / Q000378:metabolism; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005260:Female; D005557:Formaldehyde / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives / Q000494:pharmacology; D007479:Iopamidol / Q000031:analogs & derivatives / Q000494:pharmacology; D007485:Ioxaglic Acid / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C057937:iomeprol; C093233:iobitridol; D005557:Formaldehyde; D007472:Iohexol; D004492:Edetic Acid; C044834:iodixanol; D007479:Iopamidol; D007485:Ioxaglic Acid