Cytotoxic terpenoids from the Formosan soft coral Nephthea brassica.
Two new cytotoxic cembranoid diterpenes, brassicolide (1) and brassicolide acetate (2); a new cytotoxic sesquiterpene, (-)-4alpha-O-acetyl-selin-11-en (3); and six cytotoxic terpenoids, (-)-selin-11-en-4alpha-ol (4), 2-hydroxynephthenol (5), nephthenol (6), cembrene A (7), epoxycembrene A (8), and (-)-beta-elemene (9), have been isolated from the Formosan soft coral Nephthea brassica. The structures of compounds 1-9 were determined by spectral, chemical, and X-ray crystallographic analysis.
Duh
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Department of Marine Resources, National Sun Yat-sen University, Department of Microbiology, Kaohsiung Medical College, Department of Chemistry, and National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Wang
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SK
Weng
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Chiang
M Y
MY
Dai
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CF
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006574:Heterocyclic Compounds, 2-Ring / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008752:Methylene Chloride; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006574:Heterocyclic Compounds, 2-Ring; C402912:brassicolide; C402913:brassicolide acetate; D008752:Methylene Chloride