Assessment of the efficacy, safety and quality of gentamicin use in Aberdeen Royal Infirmary.
Fifty-five patients who received od gentamicin were studied. The protocol for od gentamicin was followed in 23/55 (48%). Cure rates were 22/23 (96%) when the protocol was followed and 24/32 (75%) when not followed (P = 0.06). Toxicity was more common in those in whom the protocol was not followed (9/32; 28%) than in those in whom it was followed (1/23; 4%) (P< 0.05). The number needed to treat with the protocol to produce one additional cure was 4.84 (95% CI 2.64 to 28.66) and the number needed to treat to prevent one case of toxicity was 3.61 (95% CI 2.16 to 10.99).
Buabeng
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Department of Pharmacy, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB (b)The Infection Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZB, UK.
Mackenzie
A R
AR
Laing
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RB
Cook
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Jappy
B
B
Gould
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IM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012606:Scotland; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D005839:Gentamicins