The distinct morphological and biological features of primary brain tumors and their influence upon prognosis and treatment.
Primary tumors of the central nervous system apart from features common with tumors of other organs and tissues in man show some different and distinct features which give significant meaning for prognosis and treatment. One of the most important features which characterizes their distinctness is the relation of the tumor to its surroundings. Macroscopic and microscopic evaluation of this relation decides of possibilities of an early diagnosis and totality of removal. Basing on comparison with tumors of other organs e.g. lung, stomach and liver the difficult task of differentiation of the infiltration zone with the use of morphological criteria only in glial tumors is discussed. Notice has been taken of elements which determine the limitation of totality of removal and factors conditioning the recurrences. Attention was directed on discrepancy between morphological criteria and biological activity of the tumors, specially of those which in agreement with cytogenetic classification are included to the group of tumors of astrocytic origin. Additionally, the dependency of prognosis and treatment on age and localization of the primary brain tumors have been taken into consideration.
Kałuza
J
J
Department of Neuropathology, Collegium Medicum Jagiellonian University, Kraków.
D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D007621:Karyotyping; D009154:Mutation; D011379:Prognosis