A clinical review of Charcot-Marie-Tooth.
CMT polyneuropathy is a complex genetically and clinically heterogeneous group of disorders. The rapid advances in our understanding of the molecular basis of these groups of neuropathies have helped to resolve some of the controversial issues regarding the clinical and genetic classification. However, there is still confusion and chaos in the terminology employed by different groups of researchers. A reclassification based on the molecular mechanisms of these neuropathies will help in the future to unify and simplify the diagnosis of these complex disorders. The understanding of the molecular mechanisms will also help in the future to find a way to control or treat these hereditary neuropathies.
Garcia
C A
CA
Tulane University Medical Center, Department of Psychiatry and Neurology, New Orleans, Louisiana 70112-2715, USA. cgarcia2@mailhost.tcs.tulane.edu
D002607:Charcot-Marie-Tooth Disease / Q000145:classification* / Q000235:genetics / Q000503:physiopathology*; D017630:Connexins / Q000235:genetics; D020440:Gene Duplication; D006801:Humans; D008565:Membrane Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D009419:Nerve Tissue Proteins; D011510:Proteolipids / Q000235:genetics
D017630:Connexins; D008565:Membrane Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D009419:Nerve Tissue Proteins; C048897:PLLP protein, human; D011510:Proteolipids