title: Novel tests for marker-disease association using the Collaborative Study on the Genetics of Alcoholism data.
abstract: We applied several novel tests for association and linkage in the presence of association to the Genetic Analysis Workshop 11 Problem 1 data set. Our analyses included a Hardy-Weinberg test for association between a marker and a disease susceptibility locus, a Bayesian transmission/disequilibrium test, and a Bayesian case-control test. Positive results for each of these methods require the presence of population association between the marker and a disease susceptibility locus.
authors.affiliation: Program in Statistical Genetics, North Carolina State University, Raleigh 27695-8203, USA.
authors.forename: D
authors.initials: D
authors.lastname: Nielsen
authors.forename: D
authors.initials: D
authors.lastname: Zaykin
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D000465:Algorithms; D001499:Bayes Theorem; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping; D008040:Genetic Linkage; D005819:Genetic Markers; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D015810:Linkage Disequilibrium; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers