Pathogenesis of Cryptosporidium parvum infection.
Cryptosporidium parvum can be regarded as a minimally invasive mucosal pathogen, since it invades surface epithelial cells that line the intestinal tract but does not invade deeper layers of the intestinal mucosa. Nonetheless, infection can be associated with diarrhea and marked mucosal inflammation. This article briefly reviews in vitro and in vivo models useful for studying the pathogenesis of C. parvum infection and explores the role of innate and acquired immune responses in host defense against this protozoan parasite.
Laurent
F
F
Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0623, USA.
McCole
D
D
Eckmann
L
L
Kagnoff
M F
MF
D017088:AIDS-Related Opportunistic Infections / Q000469:parasitology; D000818:Animals; D000917:Antibody Formation; D002478:Cells, Cultured / Q000469:parasitology; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000032:analysis; D003457:Cryptosporidiosis / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D016785:Cryptosporidium parvum / Q000166:cytology / Q000472:pathogenicity*; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D006133:Growth Substances / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D036341:Intercellular Signaling Peptides and Proteins; D007371:Interferon-gamma / Q000276:immunology; D016209:Interleukin-8 / Q000032:analysis; D007422:Intestines / Q000469:parasitology / Q000473:pathology; D015854:Up-Regulation
C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8; D007371:Interferon-gamma