Prolongation of rat heart allograft survival with K(+)ATP-dependent channel modulators.
Controversies exist regarding the immunoregulatory properties of K(+) ATP channel modulators. We investigated the effects of aprikalim, a K(+) ATP-dependent channels activator, and glibenclamide and gliclazide, two inhibitors of K(+) ATP-dependent channels, on the prolongation of heart allograft survival in the rat. Nine groups (n >/= 5) were involved in this study with the Brown-Norway to Lewis rat combination treated with aprikalim, glibenclamide, gliclazide, and/or cyclosporine. The results indicate that modulators of K(+) ATP-dependent channels can improve the survival of rat heart allograft without interfering with the immunosuppressive properties of cyclosporine.
Rheaume
D
D
Laboratory of Experimental Surgery, Research Center of CHUM, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
Dumont
L
L
Peng
J
J
Xu
D
D
Qi
S
S
Liu
D
D
Chen
H
H
D000818:Animals; D006085:Graft Survival / Q000502:physiology*; D016027:Heart Transplantation / Q000502:physiology*; D008297:Male; D010847:Picolines / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology*; D011714:Pyrans / Q000494:pharmacology; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
D010847:Picolines; D015221:Potassium Channels; D011714:Pyrans; D014665:Vasodilator Agents; C061043:aprikalim