title: [Transurethral alprostadil (MUSE) in erectile dysfunction].
abstract: The ideal therapy for erectile dysfunction should be easy, non invasive, painless, with a high success and a low side effects rate. Alternative methods of delivery drugs to the erectile body, instead of intracavernosal injection of vasoactive drugs such as prostaglandin, have been evaluated. Vasoactive agents can be administered topically into the urethral mucosa for absorption into the corpus spongiosum and transfer into the corpora cavernosa via small communicating veins. We report data from the literature and our experience with MUSE (Medicated Urethral System for Erection) for the treatment of erectile dysfunction. Penile pain or discomfort is the common adverse effect reported, while no priapism of fibrotic complication is reported. But local discomfort, limited efficacy, and cost are to be considered.
authors.affiliation: Divisione di Urologia e Andrologia, Ospedale S. Anna, Como, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Comeri
authors.forename: E
authors.initials: E
authors.lastname: Gianneo
authors.forename: R
authors.initials: R
authors.lastname: Nespoli
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage* / Q000009:adverse effects; D007172:Erectile Dysfunction / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D006801:Humans; D008875:Middle Aged; D014521:Urethra; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014665:Vasodilator Agents; D000527:Alprostadil
vernacular_title: Alprostadil transuretrale (MUSE) nella disfunzione erettile peniena.