title: [Gastroesophageal reflux in asthmatic patients: an incidence study and clinical correlation].
abstract: The prevalence of gastroesophageal reflux (GER) in asthmatic patients is elevated, but the exact frequency remains unknown. The relationship between GER and asthma has not been investigated in Mexico. The objective of this study is to know the frequency of GER in Mexican asthmatic patients and the possible relationship with the severity of asthma. Fifty patients with adult-onset asthma were studied. AII of them fulfill the diagnostic criteria of the National Institutes of Health, U.S. The evaluation included a symptoms questionnaire, spirometry, esophageal manometry, 24-h esophageal pH-recording, and an upper gastrointestinal endoscopy. Twenty-three patients had mild asthma (46%), 16 moderate (32%) and 11 had severe asthma (22%). Twenty-seven (54%) reported heartburn and regurgitation at least twice a week. The esophageal pH-recording showed pathologic GER in 37 subjects (74%) and endoscopic esophagitis was found in 7 cases (14%). The pH-recording showed pathologic GER in 13 patients with mild asthma (57%), in 13 with moderate asthma (81%) and in all patients with severe asthma (100%). The frequency of GER in Mexican asthmatic patients is high and increases proportionately with the severity of asthma. This factor must be considered in the integral evaluation of these patients.
authors.affiliation: Departamento de Gastroenterología, Instituto Nacional de la Nutrición, México, D.F.
authors.forename: R
authors.initials: R
authors.lastname: Carmona-Sánchez
authors.forename: M A
authors.initials: MA
authors.lastname: Valdovinos-Díaz
authors.forename: M T
authors.initials: MT
authors.lastname: Facha
authors.forename: L
authors.initials: L
authors.lastname: Aguilar
authors.forename: M
authors.initials: M
authors.lastname: Cachafeiro
authors.forename: C
authors.initials: C
authors.lastname: Flores
authors.forename: S
authors.initials: S
authors.lastname: Solana
authors.forename: G
authors.initials: G
authors.lastname: Carrillo
authors.forename: R
authors.initials: R
authors.lastname: Chapela
authors.forename: M
authors.initials: M
authors.lastname: Mejía
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Chavira
authors.forename: J
authors.initials: J
authors.lastname: Salas
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000150:complications*; D004945:Esophagoscopy; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D008297:Male; D008365:Manometry; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
vernacular_title: El reflujo gastroesofágico en pacientes asmáticos: estudio de frecuencia y correlación clínica.