title: Production of 6-deoxy-13-cyclopropyl-erythromycin B by Saccharopolyspora erythraea NRRL 18643.
abstract: Cyclopropane carboxylic acid was fed to Saccharopolyspora erythraea NRRL 18643 (6-deoxyerythromycin producer), resulting in the production of 6-deoxy-13-cyclopropyl-erythromycin B. These studies provide further evidence that deoxyerythronolide B synthase has a relaxed specificity for the starter unit.
authors.affiliation: Pfizer Central Research, Groton, CT 06340, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Brown
authors.forename: J P
authors.initials: JP
authors.lastname: Dirlam
authors.forename: H A
authors.initials: HA
authors.lastname: McArthur
authors.forename: E L
authors.initials: EL
authors.lastname: McCormick
authors.forename: B K
authors.initials: BK
authors.lastname: Morse
authors.forename: P A
authors.initials: PA
authors.lastname: Murphy
authors.forename: T N
authors.initials: TN
authors.lastname: O'Connell
authors.forename: M
authors.initials: M
authors.lastname: Pacey
authors.forename: D M
authors.initials: DM
authors.lastname: Rescek
authors.forename: J
authors.initials: J
authors.lastname: Ruddock
authors.forename: R G
authors.initials: RG
authors.lastname: Wax
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D003521:Cyclopropanes / Q000378:metabolism; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016930:Saccharopolyspora / Q000235:genetics / Q000378:metabolism*
chemical_list: C401442:6-deoxy-13-cyclopropyl-erythromycin B; D000900:Anti-Bacterial Agents; D003521:Cyclopropanes; D018942:Macrolides; C015766:cyclopropanecarboxylic acid; D004917:Erythromycin; C064662:berythromycin