title: Ehrlichia chaffeensis in a renal transplant recipient.
abstract: Since its first description in human beings in 1986, ehrlichiosis is now increasingly recognized as a cause of tick-borne febrile illnesses. However, the disease has been reported only rarely in immunosuppressed patients. We report a case of human ehrlichiosis in a patient with a cadaveric renal transplant. The diagnosis was confirmed initially by a positive polymerase chain reaction (PCR) for E. chaffeensis. The antibody titer became positive several weeks later. The patient responded promptly to treatment with doxycycline. Ehrlichiosis should be considered in the differential diagnosis of an acute febrile illness in transplant recipients. PCR provides a rapid means to confirm the diagnosis, particularly in settings in which antibody response may be suppressed.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
authors.forename: R
authors.initials: R
authors.lastname: Sadikot
authors.forename: M J
authors.initials: MJ
authors.lastname: Shaver
authors.forename: W B
authors.initials: WB
authors.lastname: Reeves
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial / Q000032:analysis; D004269:DNA, Bacterial / Q000032:analysis; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D018469:Ehrlichia chaffeensis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D016873:Ehrlichiosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007275:Injections, Intravenous; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D016133:Polymerase Chain Reaction
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D004269:DNA, Bacterial