title: Persistent ulcerated necrobiosis lipoidica responding to treatment with cyclosporin.
abstract: We report two patients with severe ulcerated necrobiosis lipoidica (NL) who responded to cyclosporin. One patient had suffered persistent ulceration for a period of 7 years and the other had NL of recent onset. In both cases, ulceration healed completely after 4 months of therapy, and both patients have remained free of ulceration since discontinuing therapy. The possible mode of action of cyclosporin in the context of this debilitating disease is discussed.
authors.affiliation: Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, UK. amritdar@btinternet.com
authors.forename: A
authors.initials: A
authors.lastname: Darvay
authors.forename: K M
authors.initials: KM
authors.lastname: Acland
authors.forename: R
authors.initials: R
authors.lastname: Russell-Jones
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine