Micronucleus assay and lymphocyte mitotic activity in risk assessment of occupational exposure to microwave radiation.
The effects of radiofrequency electromagnetic radiation (RFR) on the cell kinetics and genome damages in peripheral blood lymphocytes were determined in lymphocytes of 12 subjects occupationally exposed to microwave radiation. Results showed an increase in frequency of micronuclei (MN) as well as disturbances in the distribution of cells over the first, second and third mitotic division in exposed subjects compared to controls. According to previous reports micronucleus assay can serve as a suitable indicator for the assessment of exposure to genotoxic agents (such as RFR) and the analysis of mitotic activity as an additional parameter for the efficient biomonitoring.
Garaj-Vrhovac
V
V
Institute for Medical Research and Occupational Health, Zagreb, Croatia. vgaraj@mimi.imi.hr
D000328:Adult; D002453:Cell Cycle / Q000528:radiation effects; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects; D015162:Micronucleus Tests; D008872:Microwaves / Q000009:adverse effects*; D008875:Middle Aged; D008938:Mitosis / Q000528:radiation effects; D008991:Monitoring, Physiologic; D016273:Occupational Exposure; D011825:Radar; D018570:Risk Assessment; D012854:Sister Chromatid Exchange / Q000528:radiation effects