title: Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG).
abstract: Dual transplant of marginal kidneys otherwise not considered for single transplant may give access to an expanded pool of cadaveric organs without exposing recipients to the drawbacks of a limited nephron mass supply. This prospective, case-control study compares adverse events and graft outcome in 24 recipients of two marginal kidneys from donors who were >60 yr old or who had diabetes, hypertension, or non-nephrotic proteinuria (cases), with that of 48 age- and gender-matched control subjects who received single ideal grafts at the same center and were given the same immunosuppressive therapy. Marginal kidneys with no macroscopic abnormalities were selected for the double transplant on the basis of a predefined score of histologic damage. Six-month patient and kidney survival was 100% with both of the procedures. Incidence (20.8% versus 20.8%) and median (range) duration of posttransplant anuria (5 [2 to 12] versus 7 [2 to 13] days) were comparable in cases and control subjects, respectively. Time to normal serum creatinine and mean serum creatinine values at each time visit were comparable as well, but with significantly lower levels in cases compared with control subjects from month 2 to last follow-up (1.56 +/- 0.65 versus 1.74 +/- 0.73 mg/dl, P = 0.04). Diastolic BP values averaged during the entire posttransplant period were significantly lower in cases than in control subjects (83.2 +/- 11.5 versus 85.1 +/- 12.5 mmHg, respectively, P = 0.008). Donor/recipient body weight ratio was the only covariate significantly associated at univariate (P = 0.002) and multivariate (P = 0.001) analysis with last available serum creatinine concentrations. Incidence of acute allograft rejections (20.8% versus 18.8%) and of major surgical complications was comparable in the two groups. No renal artery or vein thrombosis was reported in either group. Dual transplants of marginal kidneys are as safe and tolerated as single transplants, and possibly offer an improved filtration power without exposing the recipient to enhanced risk of delayed renal function recovery, acute allograft rejection, or major surgical complications.
authors.affiliation: Ospedali Riuniti di Bergamo, Clinical Research Center Aldo e Cele Daccò, Bergamo, Italy. gremuzzi@cyberg.it
authors.forename: G
authors.initials: G
authors.lastname: Remuzzi
authors.forename: J
authors.initials: J
authors.lastname: Grinyò
authors.forename: P
authors.initials: P
authors.lastname: Ruggenenti
authors.forename: M
authors.initials: M
authors.lastname: Beatini
authors.forename: E H
authors.initials: EH
authors.lastname: Cole
authors.forename: E L
authors.initials: EL
authors.lastname: Milford
authors.forename: B M
authors.initials: BM
authors.lastname: Brenner
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012449:Safety; D015996:Survival Rate; D014019:Tissue Donors; D009927:Tissue and Organ Procurement
chemical_list: D003404:Creatinine