title: HLA-DR expression in acute pancreatitis.
abstract: OBJECTIVE
  To investigate the role of the monocyte/macrophage system in acute pancreatitis
  
  
  METHODS
  Prospective clinical study
  
  
  METHODS
  University clinic, Germany
  
  
  METHODS
  37 consecutive patients who presented with acute pancreatitis.
  
  
  METHODS
  Correlation between function of monocytes measured by HLA-DR expression and outcome
  
  
  RESULTS
  Patients were divided into three groups according to outcome: those with severe pancreatitis who died (n = 10), those with severe pancreatitis who survived (n = 15), and those with mild pancreatitis who survived (n = 12). There was a clear and significant difference between those with severe and those with mild disease. HLA-DR expression was initially depressed in both groups, but after the third day of treatment it started to recover significantly in those with mild disease (p < 0.05). The difference was also significant from day 7 onwards between those with severe disease who died and those with severe disease who survived (p < 0.05).
  
  
  CONCLUSIONS
  Monocyte function as measured by HLA-DR expression (CD14+DR+) is reduced in patients with acute pancreatitis and does not recover in patients who are going to die (median < 20 relative antigen density units; RU).
authors.affiliation: Department of Surgery, Universitätsklinikum Mannheim, University of Heidelberg, Mannheim, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Richter
authors.forename: T
authors.initials: T
authors.lastname: Nebe
authors.forename: K
authors.initials: K
authors.lastname: Wendl
authors.forename: K
authors.initials: K
authors.lastname: Schuster
authors.forename: G
authors.initials: G
authors.lastname: Klaebisch
authors.forename: M
authors.initials: M
authors.lastname: Quintel
authors.forename: D
authors.initials: D
authors.lastname: Lorenz
authors.forename: S
authors.initials: S
authors.lastname: Post
authors.forename: M
authors.initials: M
authors.lastname: Trede
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D019283:Pancreatitis, Acute Necrotizing / Q000276:immunology* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate
chemical_list: D006684:HLA-DR Antigens; D002097:C-Reactive Protein