title: Dose model for a beta-emitting stent in a realistic artery consisting of soft tissue and plaque.
abstract: A model for the description of the near-field dose deposition from a 32p impregnated stent in an arterial system consisting of soft tissue and dense plaque is presented. The model is based on the scaling property of the dose-point-kernel (DPK) function which is extended to a heterogeneous medium consisting of a series of layers of different materials. It is shown that, for each point source originating from the stent surface, the DPK function for water can be scaled consistently along the path through the different layers of material to predict the dose at a given point in the heterogeneous medium. Radiochromic film dosimetry on actual 32p stents is used to test the new model. The experimental setup consists of a water-equivalent phantom in which a stent is deployed and on which a thin layer of polytetrafluoroethylene (PTFE) is deposited to simulate the presence of plaque. Layers of radiochromic films stacked over the phantom are used to measure the dose at distances varying from approximately 0.1 mm to approximately 3 mm from the stent surface with and without PTFE. It is shown that the proposed new DPK model for a heterogeneous medium agrees very well with the experimental data and that it compares favorably to the usual homogeneous DPK model. These results indicate that the new model can be used with confidence to predict the dose in a realistic artery in the presence of plaque.
authors.affiliation: Centre Hospitalier de l'Université de Montréal, Dept. de Médecine Nucléaire, Québec, Canada. cjanicki@total.net
authors.forename: C
authors.initials: C
authors.lastname: Janicki
authors.forename: D M
authors.initials: DM
authors.lastname: Duggan
authors.forename: A
authors.initials: A
authors.lastname: Gonzalez
authors.forename: C W
authors.initials: CW
authors.lastname: Coffey
authors.forename: D A
authors.initials: DA
authors.lastname: Rahdert
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001918:Brachytherapy / Q000379:methods*; D002138:Calibration; D003327:Coronary Disease / Q000532:radiotherapy; D006801:Humans; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D011879:Radiotherapy Dosage / Q000592:standards; D015607:Stents