title: Changes in the pattern of growth in stature related to prenatal exposure to ionizing radiation.
abstract: OBJECTIVE
  To examine the pattern and spurt in growth and development of prenatally exposed atomic-bomb survivors and to determine whether a statistically significant radiation-related growth retardation exists.
  
  
  METHODS
  The stature of 1566 individuals exposed prenatally to the atomic bombings has been employed to study the effect of such exposure on growth. Among these survivors, 30 were severely mentally retarded, and 66 individuals on whom no physical measurements between ages 9 and 19 exist were excluded from this study. Thus this analysis rests on the measurements obtained on 1470 survivors 9 to 19 years of age at the time of examination.
  
  
  RESULTS
  When the > or =0.50 Sv group was compared to the other two prenatally exposed groups, a significant retardation of growth was observed only among those survivors exposed in the first trimester of gestation. The onset of the growth spurt among males in the three exposure groups was at approximately the same age, 11.34 years, but this was not true in females. The maximum velocity in growth for males was at 14.38 years of age, but for females no clear peak velocity was demonstrable.
  
  
  CONCLUSIONS
  A radiation-related growth retardation was demonstrable in this longitudinal study of the stature of individuals prenatally exposed. It is further demonstrated that among these survivors the growth velocity was faster in the high-dose group than in the low-dose group for both males and females.
authors.affiliation: Department of Environmental and Mathematical Science, Faculty of Environmental Science and Technology, Okayama University, Tsushima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Otake
authors.forename: W J
authors.initials: WJ
authors.lastname: Schull
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000528:radiation effects*; D002648:Child; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006128:Growth / Q000528:radiation effects*; D006801:Humans; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D009689:Nuclear Warfare; D011247:Pregnancy; D011264:Pregnancy Trimesters; D011297:Prenatal Exposure Delayed Effects