Effect of aging on the dissolution stability of glibenclamide/beta-cyclodextrin complex.
The effect of aging on the physicochemical stability of glibenclamide (GB)/beta-cyclodextrin (CD) systems and tablets made with CD-complexed GB was studied. Infrared (IR) spectrometry and X-ray diffraction analyses showed that the properties of the products were unaffected even after a storage period of 4 years, except that the crystallinity of GB/CD physical mixture was decreased with aging. The dissolution rate of the kneaded mixture, inclusion complex, and tablets made with the inclusion complex were unaffected on storage for 4 years. Thus, the age-related dissolution problems of GB can be overcome by utilizing the GB/CD complex in the tablet dosage form.
Babu
R J
RJ
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Pandit
J K
JK
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D005905:Glyburide / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013607:Tablets; D013997:Time Factors; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D012996:Solutions; D013607:Tablets; D047392:beta-Cyclodextrins; C031215:betadex; D005905:Glyburide