Dopamine D1 or D2 receptor blockade in the globus pallidus produces akinesia in the rat.
In the present study, the involvement of dopamine D1 and D2 receptors in the dorsal globus pallidus (GP) in motor control was investigated in rats. Results show that bilateral microinfusions of the dopamine D1 receptor antagonist SCH23390 or the dopamine D2 antagonist S( - )-sulpiride into the GP induced akinesia determined by means of the catalepsy test. These findings indicate that pallidal dopamine D1 and D2 receptors are critically involved in the control of motor behaviour. The findings further imply that defective dopaminergic transmission in the GP might contribute to akinesia due to lesion- or drug-induced dopamine hypofunction in experimental animals and in neurodegenerative diseases, e.g. Parkinson's disease, affecting the nigrostriatal dopamine system.
Hauber
W
W
Abteilung Tierphysiologie, Biologisches Institut, Universität Stuttgart, Germany. hauber@pa.uni-stuttgart.de
Lutz
S
S
D000818:Animals; D001345:Autoradiography; D001552:Benzazepines / Q000008:administration & dosage / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004409:Dyskinesia, Drug-Induced / Q000523:psychology*; D005917:Globus Pallidus / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009068:Movement / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D013238:Stereotaxic Techniques; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology
D001552:Benzazepines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017447:Receptors, Dopamine D1; D013469:Sulpiride