A genome-wide search for susceptibility genes linked to alcohol dependence.
We performed two-point linkage analysis during a genome-wide search for susceptibility genes that predispose to alcohol dependence with the Collaborative Study on the Genetics on Alcoholism (COGA) data made available for the Genetic Analysis Workshop 11 (GAW11). For chromosomes 1 and 4 our findings supported results reported by Reich et al. [1998] based on the same data. We found similarity between our findings in regions on chromosomes 8 and 10 and reported results for schizophrenia linkage studies. Differences between our results with COGA data and those obtained by Reich et al. [1998] are due to our use of a lod score method versus their use of the affected relative pair (sib pair) method.
Peterson
L E
LE
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.
Barnholtz
J S
JS
Page
G P
GP
King
T M
TM
de Andrade
M
M
Amos
C I
CI
D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002894:Chromosomes, Human, Pair 4; D002898:Chromosomes, Human, Pair 8; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D016678:Genome; D006801:Humans; D008126:Lod Score
D005819:Genetic Markers