title: IL-6 and IL-8 levels after cardiopulmonary bypass are not affected by surface coating.
abstract: BACKGROUND.:Contact of blood with the surfaces of the cardiopulmonary bypass (CPB) circuit has been implicated as a cause of the inflammatory response. We undertook a prospective randomized trial of 200 pediatric patients, all with a calculated total bypass flow of less than 2.3 L/min (< 0.96 L/m2/min).
  
  
  METHODS
  Patients were randomly assigned to 1 of 4 CPB groups: (1) Nonheparin-bonded circuit with no albumin preprime; (2) Nonheparin-bonded circuit with albumin preprime; (3) Heparin-bonded circuit with no albumin preprime; (4) Heparin-bonded circuit with albumin preprime. Measurements of cytokines, (interleukin [IL]-6, IL-8) and blood cell counts were made prebypass and 6 and 24 hours after institution of cardiopulmonary bypass.
  
  
  RESULTS
  Analysis of variance showed no significant difference in any of the clinical or biochemical characteristics of the 4 groups. The interaction between heparin-bonded oxygenators and albumin preprime was not significant. No important differences in IL-6 or IL-8 concentrations were noted after CPB using either heparin or nonheparin-bonded oxygenators with albumin or albumin free preprime using two-way analysis of variance.
  
  
  CONCLUSIONS
  Albumin preprime and heparin-bonding do not attenuate the inflammatory response component attributable to the concentration of these markers.
authors.affiliation: Cardiac Surgical Unit, Royal Children's Hospital, Melbourne, Australia.
authors.forename: S B
authors.initials: SB
authors.lastname: Horton
authors.forename: W W
authors.initials: WW
authors.lastname: Butt
authors.forename: R J
authors.initials: RJ
authors.lastname: Mullaly
authors.forename: C A
authors.initials: CA
authors.lastname: Thuys
authors.forename: E B
authors.initials: EB
authors.lastname: O'Connor
authors.forename: K
authors.initials: K
authors.lastname: Byron
authors.forename: A D
authors.initials: AD
authors.lastname: Cochrane
authors.forename: C P
authors.initials: CP
authors.lastname: Brizard
authors.forename: T R
authors.initials: TR
authors.lastname: Karl
mesh_terms: D000418:Albumins; D002315:Cardiopulmonary Bypass; D002648:Child; D020099:Coated Materials, Biocompatible; D006330:Heart Defects, Congenital / Q000276:immunology / Q000601:surgery; D006493:Heparin; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D010107:Oxygenators, Membrane; D011183:Postoperative Complications / Q000276:immunology*; D011446:Prospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology*
chemical_list: D000418:Albumins; D020099:Coated Materials, Biocompatible; D015850:Interleukin-6; D016209:Interleukin-8; D006493:Heparin