title: Pharmacologic considerations in the treatment of neonatal septicemia and its complications.
abstract: This article focuses on the pharmacologic properties of drugs commonly used in the treatment of neonatal septicemia and its complications. Rational therapy demands an awareness of not only the pharmacology of individual drugs but also the interactions and anticipated fate of such drugs in the rapidly changing physiologic environment of the neonate. Further research in the area of equine neonatal pharmacology should greatly assist our understanding of the impact of the disease state on the unique physiology of the newborn and should allow us to better predict the ultimate fate of drugs commonly used for such purposes. Careful dosing and close monitoring of pharmacologic effects are critical for a successful outcome. In the future, newer therapeutic strategies that are safe and efficacious may provide a means to circumvent many of the problems currently encountered with treating the septicemic newborn foal.
authors.affiliation: Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada. mwichtel@upei.ca
authors.forename: M E
authors.initials: ME
authors.lastname: Wichtel
authors.forename: E
authors.initials: E
authors.lastname: Buys
authors.forename: J
authors.initials: J
authors.lastname: DeLuca
authors.forename: G
authors.initials: G
authors.lastname: Stringel
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000930:Antidiarrheals / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000662:veterinary*; D013449:Sulfonamides / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000930:Antidiarrheals; D002511:Cephalosporins; D006635:Histamine H2 Antagonists; D006993:Hypnotics and Sedatives; D013449:Sulfonamides