Molecular motors: sensing a function for myosin-VIIa.
Mutations affecting myosin-VIIa are known to cause deafness and blindness in human Usher syndrome. Mutation of the Dictyostelium myosin-VII gene has now revealed a role for this unconventional myosin in phagocytic events, providing a possible clue to the role of mammalian myosin-VIIa in the inner ear and retina.
Hasson
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Department of Biology, University of California at San Diego, La Jolla, 92093-0368, USA. tama@ucsd.edu
D000199:Actins / Q000502:physiology; D000818:Animals; D001766:Blindness / Q000151:congenital / Q000235:genetics; D003599:Cytoskeleton / Q000502:physiology; D003638:Deafness / Q000151:congenital / Q000235:genetics; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology; D004398:Dyneins; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology; D018390:Gene Targeting; D006198:Hair Cells, Auditory / Q000378:metabolism; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D020409:Molecular Motor Proteins / Q000235:genetics; D000081412:Myosin VIIa; D009218:Myosins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D010316:Particle Size; D010587:Phagocytosis / Q000502:physiology*; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D013577:Syndrome
D000199:Actins; D005136:Eye Proteins; C000631455:MYO7A protein, human; D020409:Molecular Motor Proteins; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; D009419:Nerve Tissue Proteins; D015800:Protozoan Proteins; D009218:Myosins; D004398:Dyneins