Cytoskeletal linkers: new MAPs for old destinations.
A new isoform of the actin-neurofilament linker protein BPAG has been found that binds to and stabilizes axonal microtubules. This and other newly identified microtubule-associated proteins are likely to be just the tip of an iceberg of multifunctional proteins that stabilize and crosslink cytoskeletal filament networks.
Houseweart
M K
MK
Program in Biomedical Sciences, Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, 92093, USA.
Cleveland
D W
DW
D008841:Actin Cytoskeleton / Q000737:chemistry / Q000648:ultrastructure; D000199:Actins / Q000502:physiology / Q000648:ultrastructure; D017398:Alternative Splicing; D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins; D003094:Collagen / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D005057:Eukaryotic Cells / Q000378:metabolism / Q000648:ultrastructure; D007381:Intermediate Filament Proteins / Q000737:chemistry / Q000502:physiology; D046911:Macromolecular Substances; D051379:Mice; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D024041:Non-Fibrillar Collagens; D051190:Plectin; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D012107:Research Design; D013329:Structure-Activity Relationship; D000097805:Collagen Type XVII
D000199:Actins; D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D007381:Intermediate Filament Proteins; D046911:Macromolecular Substances; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D051190:Plectin; D020033:Protein Isoforms; D000097805:Collagen Type XVII; C095667:Dst protein, mouse; C495333:Plec protein, mouse