title: Microbiological spectrum of septicemia and peritonitis in nephrotic children.
abstract: From April 1993 to December 1997, 452 admissions of 231 children with nephrotic syndrome to Chang Gung Children's Hospital were retrospectively reviewed. There were 10 episodes of sepsis and 8 episodes of peritonitis in 18 children, and 14 microorganisms were cultured. Two children died due to Streptococcus pneumoniae sepsis. Gram-positive microorganisms (n=7) and Gram-negative microorganisms (n=7) were found in equal numbers. Enterococcus (1), Streptococcus pneumoniae (4), group D streptococcus (1), and Streptococcus viridans (1) were the Gram-positive microorganisms cultured. Two of 4 cases of Streptococcus pneumoniae sepsis were penicillin resistant. Gram-negative microorganisms included Enterobacter cloacae (1), Klebsiella pneumoniae (1), Escherichia coli (2), Acinetobacter baumannii (1), Neisseria meningitidis (1), and group B salmonella (1). The last three microorganisms have not been previously associated with nephrotic children. Vancomycin therapy to cover penicillin-resistant Streptococcus pneumoniae and a third-generation cephalosporin therapy to cover rare Gram-negative microorganisms should be considered in serious infections of nephrotic children.
authors.affiliation: Division of Pediatric Nephrology, Chang Gung Children's Hospital, 5 Fu-Hsing Street, Kweishan 333, Taoyuan, Taiwan.
authors.forename: Y L
authors.initials: YL
authors.lastname: Tain
authors.forename: G
authors.initials: G
authors.lastname: Lin
authors.forename: T W
authors.initials: TW
authors.lastname: Cher
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000382:microbiology*; D010538:Peritonitis / Q000150:complications / Q000382:microbiology*; D012189:Retrospective Studies; D018805:Sepsis / Q000150:complications / Q000382:microbiology*