title: The influence of inspiratory hyperoxia on ischemia-reperfusion-induced tumour growth delay.
abstract: We investigated the ischemia-reperfusion-induced tumour growth delay as a function of ischemic time, tumour temperature, and the amount of inspired oxygen during reperfusion. The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C. Five minutes prior to and 10 min during reperfusion the animals respired air, pure oxygen or carbogen (95% O2, 5% CO2). Comparison of single treatment modalities with untreated controls revealed significant tumour growth delays after clamping times of 4 h at 37 degrees C for air and pure oxygen, but not for carbogen.
authors.affiliation: Department of Radiation Oncology, University of Dusseldorf, D-40225 Dusseldorf, Germany.
authors.forename: K A
authors.initials: KA
authors.lastname: Hartmann
authors.forename: U M
authors.initials: UM
authors.lastname: Carl
authors.forename: P
authors.initials: P
authors.lastname: Sminia
authors.forename: G
authors.initials: G
authors.lastname: Lammering
authors.forename: K A
authors.initials: KA
authors.lastname: Becker
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D002455:Cell Division; D007511:Ischemia / Q000473:pathology*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015424:Reperfusion; D012208:Rhabdomyosarcoma / Q000098:blood supply* / Q000473:pathology
chemical_list: D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen