title: Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits.
abstract: The purpose of this study was to characterize the ocular pharmacokinetics of a beta-blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretion deficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetration parameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits.
authors.affiliation: Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamamura
authors.forename: T
authors.initials: T
authors.lastname: Mukai
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Nakashima
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000465:Algorithms; D000758:Anesthesia; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D005123:Eye; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D013666:Tears / Q000378:metabolism
chemical_list: D000319:Adrenergic beta-Antagonists; D007546:Isoquinolines; C036593:tilisolol