Polyarthritis nodosa with mesenteric aneurysms demonstrated by angiography: report of a case and successful treatment of the patient with prednisolone and cyclophosphamide.
Polyarteritis nodosa is a necrotizing angitis that predominantly affects small and medium-sized arteries. The prognosis of untreated polyarteritis nodosa is very poor. Since symptoms are diverse and no serologic test is specific for polyarteritis nodosa, the diagnosis is difficult and often delayed. We describe a patient with polyarteritis nodosa who had gastrointestinal involvement with multiple aneurysms of the inferior mesenteric artery; only abdominal angiography provided a conclusive diagnosis. Alleviation of symptoms and regression of aneurysms were observed after combination therapy of an immunosuppressive agent, cyclophosphamide, and prednisolone. We emphasize the importance of early diagnosis by angiography and aggressive therapy in patients in whom physical signs indicating definite polyarteritis nodosa are not present.
Harada
M
M
Second Department of Medicine, Kurume University School of Medicine, Asahimachi, Japan.
Yoshida
H
H
Ikeda
H
H
Yoshida
T
T
Takedatsu
H
H
Nagamatsu
H
H
Koga
K
K
Fujisawa
Y
Y
Sakamoto
M
M
Fujisaki
K
K
Sakisaka
S
S
Yasumoto
K
K
Toyonaga
A
A
Sata
M
M
D000783:Aneurysm / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D017537:Mesenteric Artery, Inferior; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use*; D011859:Radiography
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone