New evidence for the spasm-of-resistance-vessel concept of ischemic diseases.
The spasm of resistance vessel (S-RV) concept of ischemic diseases avers that S-RV representing vascular autoregulatory dysfunction directly induces symptoms in ischemic diseases. The most important ischemic diseases, ischemic heart disease (IHD) and stroke, generally are not attributed to S-RV, and new evidence will be provided in this communication that S-RV induces IHD and stroke. Hypertension and the ischemic disorders of migraine and Raynaud's disease have been attributed to S-RV and to vascular dysregulation, and this information was used to help structure the study. It was found that these disorders are closely associated with IHD and stroke, and this is consistent with S-RV and vascular dysregulation as the mechanism for IHD and stroke. Also, it was found that multiple risk factors for IHD foster S-RV and are risk factors for hypertension, migraine, Raynaud's disease, and stroke, and this supports S-RV as the mechanism for IHD and stroke.
Hellstrom
H R
HR
Department of Pathology, Health Science Center at Syracuse, State University of New York, 13210, USA. hellstro@localnet.com
D000818:Animals; D001808:Blood Vessels / Q000502:physiology / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011928:Raynaud Disease / Q000503:physiopathology; D020521:Stroke / Q000503:physiopathology