Novel glutathione analogues containing the dithiol and disulfide form of the Cys-Cys dyad.
The glutathione analogue gamma-(H-Glu-OH)-Cys-Cys-OH (5), containing the 8-membered disulfide ring -Cys-Cys replacing the native-Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form gamma-(H-Glu-OH)-Cys-Cys-OH (6).
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Dipartimento di Studi Farmaceutici, Università La Sapienza, Roma.
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Luisi
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Pinnen
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D003545:Cysteine / Q000032:analysis*; D004151:Dipeptides / Q000032:analysis; D004220:Disulfides / Q000737:chemistry*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000737:chemistry; D018716:Molecular Mimicry; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
D004151:Dipeptides; D004220:Disulfides; D014050:Toluene; D005978:Glutathione; D003545:Cysteine; C004848:dithiol