[Synthesis of tumor affinity label Yb-169- and Y-90- porphyrin complexes and animal experimental investigations with various Yb-169-porphyrins].
OBJECTIVE
It should be shown, that it is possible to insert radioactive isotopes of Yb and Y into some selected porphyrins. Besides, first informations about the biodistribution of Yb-169-por-phyrin-complexes should be obtained.


METHODS
Carrier added radioactive isotopes were used for the synthesis of the metal porphyrin complexes. The animal experiments were done with mamma carcinoma bearing mice. The activity of the organs was determined 5 and 24 h after i.v. injection in a well counter.


RESULTS
Four Yb-169-porphyrin complexes and Y-90-porphyrin complexes could be synthesized in non-carrier-free form. This was verified by absorption spectra, TLC and HPLC. Depending on the complex, the average tumour/background ratios were between 2 and 20.


CONCLUSIONS
The synthesized radioactive metal-porphyrin complexes showed a clear tumour-affinity which could be used for tumour scintigraphy or perhaps therapy if the synthesis is improved (goal: reduction of carrier, other radionuclides).
Schomäcker
K
K
Klinik und Poliklinik für Nuklearmedizin, Universität zu Köln, Deutschland. Klaus.Schomaecker@uni-koeln.de
Gaidouk
M I
MI
Rumyantseva
V D
VD
Fischer
T
T
Löhr
H
H
Salditt
S
S
Liebenhoff
S
S
Schicha
H
H
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D011166:Porphyrins / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution; D015018:Ytterbium / Q000493:pharmacokinetics*; D015021:Yttrium Radioisotopes / Q000493:pharmacokinetics*
D011166:Porphyrins; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes; D015018:Ytterbium
Synthese tumoraffiner Yb-169- und Y-90-Porphyrin-Komplexe und tierexperimentelle Untersuchung verschiedener Yb-169-Porphyrine.