Diuretic effects on calcium metabolism.
Diuretics have numerous effects on calcium metabolism. The loop diuretics promote, and the thiazide diuretics inhibit, renal calcium excretion. In this review we detail the basic mechanisms of renal calcium excretion and then explain how diuretics influence this excretion. Finally we review how these agents can be used to alter calcium homeostasis in a clinically efficacious manner.
Friedman
P A
PA
Department of Pharmacology, University of Pittsburgh, PA, USA.
Bushinsky
D A
DA
D000818:Animals; D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects*; D004232:Diuretics / Q000145:classification / Q000494:pharmacology*; D006801:Humans; D007686:Kidney Tubules, Distal / Q000187:drug effects* / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000502:physiology; D008138:Loop of Henle / Q000187:drug effects* / Q000502:physiology
D015220:Calcium Channels; D004232:Diuretics; D002118:Calcium