Cardiac allograft valvulopathy: a case of donor-anorexigen-induced valvular disease.
We report on the transplantation of a cardiac allograft from a donor with prolonged exposure to anorexigens. This event allowed us to not only examine the early pathological alterations that characterize anorexigen-induced valvular damage, but to also study the posttransplantation outcome after the donor heart had been removed from the offending milieu. A donor history of anorexigen use should be sought, and if detected, careful evaluation for underlying valvular disease should be entertained. Early valvulopathy may appear clinically mild yet pathologically significant. Our single-case experience also suggests that anorexigen-induced valvulopathy may be a progressive disorder despite removal of the heart from the causative environment.
Prasad
A
A
Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Medical Institutions, New Orleans, Louisiana, USA.
Mehra
M
M
Park
M
M
Scott
R
R
Uber
P A
PA
McFadden
P M
PM
D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D018450:Disease Progression; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D005500:Follow-Up Studies; D016027:Heart Transplantation / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D010645:Phentermine / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D014019:Tissue Donors
D001067:Appetite Depressants; D005277:Fenfluramine; D010645:Phentermine