Immunosuppressive diterpenoids from Tripterygium wilfordii.
A clinically used extract of Tripterygium wilfordii afforded three new diterpenoids-3beta,19-dihydroxyabieta-8,11,13-triene (triptobenzene L) (1); 12,19-dihydroxy-3-oxoabieta-8,11,13-triene (triptobenzene M) (2); and 19-hydroxy-3,7-dioxo-abieta-8,11, 13-triene (triptobenzene N) (3)-along with 14 known diterpenoids. The structures of 1-3 were established on the basis of spectroscopic studies. Of the known compounds, the stereochemistry at C-4 of triptonediol (4) was reassigned. Tripterifordin (8) and 13-epi-manoyl oxide-18-oic acid (9) showed significant inhibitory effects on cytokine production.
Duan
H
H
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
Takaishi
Y
Y
Momota
H
H
Ohmoto
Y
Y
Taki
T
T
Jia
Y
Y
Li
D
D
D045784:Abietanes; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood; D003864:Depression, Chemical; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D011239:Prednisolone / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D045784:Abietanes; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007166:Immunosuppressive Agents; D010616:Phenanthrenes; C402914:triptobenzene L; C402915:triptobenzene M; C402916:triptobenzene N; D011239:Prednisolone