[The chronicity of HIV infection].
The widespread use of highly active antiretroviral therapy led to a substantial decrease of HIV related-morbidity and mortality in industrialized countries. These recent advances allow to envisage a chronicity of HIV infection and led HIV infected people to set up a familial or professional life-project, difficult to imagine until now. The increase in life-expectancy is nevertheless closely dependent on the prolonged adherence of the patients to therapy, which justifies the development of strategies to increase medication compliance. The side-effects of long-term taken drugs often impair the quality of life of HIV infected people: abnormal fat distribution and atherogen hyperlipidemia and insulin resistance, mainly described with protease inhibitors, are new worrying concerns. Chronicity of HIV infection favours also the development of co-morbidity (HIV-HCV co-infection). The necessity of a more global and varied case management of people living with HIV is emerging simultaneously with a new dynamic of clinical research whose ultimal goal still remains the achievement of HIV eradication strategies.
Morlat
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P
Service de médecine interne et maladies infectieuses Hôpital Saint-André, Bordeaux.
D017088:AIDS-Related Opportunistic Infections / Q000503:physiopathology; D000273:Adipose Tissue / Q000187:drug effects; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D019090:Case Management; D002908:Chronic Disease; D003240:Connective Tissue Diseases / Q000139:chemically induced; D019049:Developed Countries; D015658:HIV Infections / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control / Q000523:psychology; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D007333:Insulin Resistance; D008017:Life Expectancy; D010349:Patient Compliance; D011788:Quality of Life; D015996:Survival Rate
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors
Chronicité de l'infection par le VIH.