title: Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties.
abstract: New antibiotic compounds, melithiazols, were isolated from the culture broth of strains of the myxobacteria Melittangium lichenicola, Archangium gephyra, and Myxococcus stipitatus. The compounds belong to the group of beta-methoxyacrylate (MOA) inhibitors and are related to the myxothiazols. The melithiazols show high antifungal activity, but are less toxic than myxothiazol A and its methyl ester in a growth inhibition assay with mouse cell cultures. The melithiazols inhibit NADH oxidation by submitochondrial particles from beef heart. Melithiazol A blocks the electron transport within the bc1-segment (complex III) and causes a red shift in the reduced spectrum of cytochrome b.
authors.affiliation: GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Braunschweig, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Sasse
authors.forename: B
authors.initials: B
authors.lastname: Böhlendorf
authors.forename: M
authors.initials: M
authors.lastname: Herrmann
authors.forename: B
authors.initials: B
authors.lastname: Kunze
authors.forename: E
authors.initials: E
authors.lastname: Forche
authors.forename: H
authors.initials: H
authors.lastname: Steinmetz
authors.forename: G
authors.initials: G
authors.lastname: Höfle
authors.forename: H
authors.initials: H
authors.lastname: Reichenbach
authors.forename: M
authors.initials: M
authors.lastname: Hermann
mesh_terms: D000179:Acrylates / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D019069:Cell Respiration / Q000187:drug effects*; D003573:Cytochrome b Group / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D007223:Infant; D020128:Inhibitory Concentration 50; D008689:Methacrylates; D051379:Mice; D008826:Microbial Sensitivity Tests; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D009231:Myxococcales / Q000737:chemistry / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D000073739:Strobilurins; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000179:Acrylates; D000935:Antifungal Agents; D003573:Cytochrome b Group; D005231:Fatty Acids, Unsaturated; D008689:Methacrylates; D000073739:Strobilurins; D013844:Thiazoles; C401242:melithiazol A; C401243:melithiazol B; C401244:melithiazol C; D009243:NAD; C008556:mucidin; C030517:myxothiazol; C023324:oudemansin