Analysis of a de novo complex chromosome rearrangement involving chromosomes 4, 11, 12 and 13 and eight breakpoints by conventional cytogenetic, fluorescence in situ hybridization and spectral karyotyping.
A complex chromosome rearrangement (CCR) with eight breakpoints resulting in four derivative chromosomes (4, 11, 12 and 13) was detected prenatally in a male fetus of a twin pregnancy. The karyotype of the female second fetus was normal. The apparently balanced de novo CCR was identified by classical cytogenetic methods and fluorescence in situ hybridization (FISH). We compared these findings with results from spectral karyotyping (SKY).
Peschka
B
B
Institute of Human Genetics, University of Bonn, Bonn, Germany.
Leygraaf
J
J
Hansmann
D
D
Hansmann
M
M
Schröck
E
E
Ried
T
T
Engels
H
H
Schwanitz
G
G
Schubert
R
R
D000025:Abortion, Eugenic; D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D002882:Chromosomes, Human, Pair 13; D002894:Chromosomes, Human, Pair 4; D003937:Diagnosis, Differential; D004200:Diseases in Twins / Q000196:embryology / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D011272:Pregnancy, Multiple; D014427:Twins; D016216:Ultrasonography, Prenatal