title: [Role of positron emission tomography (PET) and single photon emission tomography (SPECT) in so-called "multiple chemical sensitivity"].
abstract: Functional imaging with SPECT and PET is increasingly used to prove evidence for the existence of a syndrome "Multiple Chemical Sensitivity" (MCS) and plays a major role in legal trials to justify compensation for the exposure to solvents. This paper critically reviews the literature on the use of SPECT and PET for the determination of MCS. The authors come to the conclusion that the current data are not sufficient to justify the claim of the existence of such a syndrome. The low specificity of the observed PET and especially SPECT-findings makes it very difficult to establish a cause-result relationship and therefore makes the use of these methods in legal trials on this issue doubtful.
authors.affiliation: Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin, Deutschland. Bartenstein@nuklear.klinik.uni-mainz.de
authors.forename: P
authors.initials: P
authors.lastname: Bartenstein
authors.forename: F
authors.initials: F
authors.lastname: Grünwald
authors.forename: K
authors.initials: K
authors.lastname: Herholz
authors.forename: T
authors.initials: T
authors.lastname: Kuwert
authors.forename: K
authors.initials: K
authors.lastname: Tatsch
authors.forename: O
authors.initials: O
authors.lastname: Sabri
authors.forename: C
authors.initials: C
authors.lastname: Weiller
mesh_terms: D006801:Humans; D018777:Multiple Chemical Sensitivity / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
vernacular_title: Rolle der Positronen-Emissions-Tomographie (PET) und Single-Photon-Emissions-Tomographie (SPECT) bei der sogenannten "Multiple Chemical Sensitivity" (MCS).