Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia.
A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50% inhibitory concentration (EC50) of 14 micrograms/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 micrograms/ml, no cytotoxicity was observed for both the Vero and MT4 cells. The fraction only inhibited the blood coagulation process at concentrations considerably exceeding the EC50.
Bergé
J P
JP
Laboratoire de Biochimie et molécules Marines, IFREMER, Nantes, France.
Bourgougnon
N
N
Alban
S
S
Pojer
F
F
Billaudel
S
S
Chermann
J C
JC
Robert
J M
JM
Franz
G
G
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology*; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D017377:Diatoms / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D014709:Vero Cells
D019380:Anti-HIV Agents; D000925:Anticoagulants; D000998:Antiviral Agents; D002241:Carbohydrates; D010936:Plant Extracts