title: Carbohydrates in transplantation.
abstract: Carbohydrate materials have become increasingly utilized in transplantation and cell/tissue engineering within the past year. This has been well documented in recent applications of immobilized or soluble alpha-galactosyl epitopes (i.e. oligosaccharides with a terminal Galalpha1-3Gal sequence) in preventing hyperacute rejection in pig-to-primate xenotransplantation. In addition, alpha-galactosyl polymers have been shown to exhibit much greater activity (up to 10(4) times) than alpha-galactosyl monomers in inhibiting the binding of anti-galactosyl antibodies to pig kidney epithelial cells and assisting in the prevention of cytotoxicity in human serum.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: P R
authors.initials: PR
authors.lastname: Andreana
authors.forename: P G
authors.initials: PG
authors.lastname: Wang
mesh_terms: D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008969:Molecular Sequence Data; D014181:Transplantation Immunology / Q000187:drug effects*
chemical_list: D002241:Carbohydrates; D007166:Immunosuppressive Agents