Elevated oxidative stress in models of normal brain aging and Alzheimer's disease.
Age-associated neurodegenerative disorders are becoming more prevalent as the mean age of the population increases in the United States over the next few decades. Both normal brain aging and Alzheimer's disease (AD) are associated with oxidative stress. Our laboratory has used a wide variety of physical and biochemical methods to investigate free radical oxidative stress in several models of aging and AD. Beta-amyloid (A beta), the peptide that constitutes the central core of senile plaques in AD brain, is associated with free radical oxidative stress and is toxic to neurons. This review summarizes some of our studies in aging and A beta-associated free radical oxidative stress and on the modulating effects of free radical scavengers on neocortical synaptosomal membrane damage found in aging and A beta-treated systems.
Butterfield
D A
DA
Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington 40506-0055, USA.
Howard
B
B
Yatin
S
S
Koppal
T
T
Drake
J
J
Hensley
K
K
Aksenov
M
M
Aksenova
M
M
Subramaniam
R
R
Varadarajan
S
S
Harris-White
M E
ME
Pedigo
N W
NW
Carney
J M
JM
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism
D016229:Amyloid beta-Peptides; D005609:Free Radicals; D017382:Reactive Oxygen Species