title: Experimental salmonellosis in guinea-pigs: haematological and biochemical studies.
abstract: Some haematological and biochemical parameters were studied in guinea-pigs infected intraperitoneally with Salmonella dublin 493 at 1 x 10(6) viable cells per animal. The infected animals showed a rise in temperature within 24 h, followed by depression and loss of body weight. On the 15th day post infection, haematological studies revealed a significant increase in the total leukocyte count due to both lymphocytosis and neutrophilia, and a decrease in the total erythrocyte count and haemoglobin concentration. There was also a significantly higher mean corpuscular volume and lower mean corpuscular haemoglobin concentration, indicating a macrocytic hypochromic anaemia. The infection caused a significant increase in alanine aminotransferase activity and creatinine, blood urea nitrogen and globulin concentrations, and a decrease in albumin and triiodothyronine. There was no significant effect on serum total protein or on thyroxine, or in the activity of aspartate aminotransferase in the serum.
authors.affiliation: Department of Veterinary Pathology, CCS Haryana Agricultural University, Hisar, India.
authors.forename: R P
authors.initials: RP
authors.lastname: Gupta
authors.forename: P C
authors.initials: PC
authors.lastname: Verma
authors.forename: G C
authors.initials: GC
authors.lastname: Chaturvedi
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001806:Blood Urea Nitrogen; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000382:microbiology / Q000503:physiopathology*; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004906:Erythrocyte Count / Q000662:veterinary; D006168:Guinea Pigs; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008297:Male; D012475:Salmonella / Q000472:pathogenicity*; D012481:Salmonella Infections, Animal / Q000097:blood / Q000503:physiopathology*; D012712:Serum Globulins / Q000032:analysis; D013154:Spleen / Q000473:pathology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D006454:Hemoglobins; D012712:Serum Globulins; D014284:Triiodothyronine; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013974:Thyroxine