[The influences of genetic and environmental factors on plasma plasminogen activator inhibitor-1 levels in patients with essential hypertension].
OBJECTIVE
To investigate the influence of a 4G/5G polymorphism in the PAI-1 gene promoter and environmental factors on plasma plasminogen activator inhibitor-1(PAI-1) levels in subjects with essential hypertension.


METHODS
A total of 240 patients with essential hypertension(males 120, females 120, aged 33-89 years, mean 65 years) were randomly enrolled in this study. Plasma PAI-1 antigen was measured by ELISA. The 4G/5G polymorphism was analyzed by the allele specific oligonucleotide hybridization method.


RESULTS
Plasma PAI-1 levels were significantly associated with 4G/5G polymorphism with the highest levels occurring in subjects with 4G/4G genotype, the intermediate levels in 4G/5G subjects and the lowest levels in 5G/5G subjects. 4G/5G polymorphism, diabetes mellitus and triglyceride(TG) were three independent predictors of plasma PAI-1 levels in a stepwise multiple regression model. Furthermore, the relationship between plasma PAI-1 levels and TG was genotype dependent.


CONCLUSIONS
Plasma PAI-1 levels are not only under genetic control, but also influenced by several environmental factors. There is an interaction between genetic and environmental factors.
Song
Y
Y
Department of Cardiology, Ganquan Hospital, Shanghai Tiedao University Medical School, Shanghai 200065 P.R.China. drlily@kali.com.cn
Xu
W
W
Chen
Y
Y
Che
L
L
Wang
Q
Q
Zhou
X
X
Wu
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004777:Environment; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic
D017395:Plasminogen Activator Inhibitor 1