title: Lack of effects of moderate-high altitude upon lung function in healthy middle-aged volunteers.
abstract: This study investigates the effects of moderate-high altitude on lung function and exercise performance in 46 volunteers (19 females, 27 males), with a mean age of 42.4 +/- 1.4 years (+/- SEM) and varying smoking and exercise habits, who were not previously acclimatized. Measures obtained in the base camp (1140 m) and at altitude (2630 m), in random order, included forced spirometry, maximal voluntary ventilation, maximal inspiratory and expiratory pressures, arterial oxygen saturation and capillary lactate concentration after a standardized exercise test. The smoking history, Fagerström test and degree of habitual physical activity were also recorded for each participant. The percentage of smokers was similar in males (19%) and females (21%) (P = n.s.). Mean habitual physical activity index was 8.2 +/- 0.2 (range, 5.88-11.63). At the base camp, all lung function variables were within the normal range. Lactate concentration after exercise averaged 3.7 +/- 0.3 mm l-1. No significant change was observed at altitude, except for a higher heart rate and a lower arterial oxygen saturation (SaO2) (both at rest and after inspiratory manoeuvres). The smoking history and the degree of physical activity did not influence lung function or exercise performance at altitude. The results of this study show that in middle-aged, healthy, not particularly well-trained individuals, lung function is not significantly altered by moderate-high altitude, despite the absence of any acclimatization period and independent of their smoking history and previous exercise habits.
authors.affiliation: Servicio de Neumología of Hospital Santa Creu i de Sant Pau, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Casan
authors.forename: B
authors.initials: B
authors.lastname: Togores
authors.forename: J
authors.initials: J
authors.lastname: Giner
authors.forename: I
authors.initials: I
authors.lastname: Nerin
authors.forename: F
authors.initials: F
authors.lastname: Drobnic
authors.forename: L
authors.initials: L
authors.lastname: Borderias
authors.forename: J
authors.initials: J
authors.lastname: Caminero
authors.forename: F
authors.initials: F
authors.lastname: Duce
authors.forename: A G
authors.initials: AG
authors.lastname: Agusti
mesh_terms: D000531:Altitude; D005080:Exercise Test; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012129:Respiratory Function Tests; D012907:Smoking / Q000503:physiopathology
chemical_list: D019344:Lactic Acid; D010100:Oxygen