[Survival and impact of bronchiolitis obliterans syndrome after lung transplantation at the Academic Hospital Groningen, 1990/'98].
OBJECTIVE
To describe the results of the lung transplantation programme in Groningen in relation to the bronchiolitis obliterans syndrome (BOS), in the first 118 consecutive patients.


METHODS
Retrospective.


METHODS
Data were collected on the 118 patients subjected to lung transplantation in November 1990 to June 1998 in the University Hospital Groningen, the Netherlands, regarding the prevalence of chronic transplant dysfunction (BOS) and survival.


RESULTS
117 lung transplantations (95 bilateral lung transplantations including 2 retransplants, and 22 single lung transplantations) and 1 heart-lung transplantation had been performed. The patients were 70 males and 48 females with a mean age of 42 years (range: 9-64). The mean (SD) survival at 1, 2, 3 and 5 years post transplantation was 83% (3), 70% (4), 66% (5) and 61% (5) respectively. The median survival amounted to 2447 days. The mean (SD) prevalence of BOS at respectively 1, 2, 3 and 5 years post transplantation was 32% (5), 36% (5), 44% (5) en 54% (6). After a diagnosis of BOS stage I the median survival was 649 days.


CONCLUSIONS
The survival of the lung transplant programme of the University Hospital Groningen is considered to compare favourably with other centres. The prevalence of BOS is considerable, and comparable with the prevalence of BOS reported by other programmes. BOS is associated with a decreased life expectancy.
van den Berg
J W
JW
Afd. Longziekten, Academisch Ziekenhuis, Groningen.
van der Bij
W
W
de Boer
W J
WJ
Postma
D S
DS
Timens
W
W
Koëter
G H
GH
D000046:Academic Medical Centers / Q000706:statistics & numerical data*; D000293:Adolescent; D000328:Adult; D001989:Bronchiolitis Obliterans / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008017:Life Expectancy; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D015996:Survival Rate
Overleving en impact van bronchiolitis-obliteranssyndroom na longtransplantaties, verricht in het Academisch Ziekenhuis Groningen, 1990/'98.