title: Inhibition of mast cell degranulation by tanshinones from the roots of Salvia miltiorrhiza.
abstract: The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC50 values were calculated as 16 and 36 microM, respectively.
authors.forename: S Y
authors.initials: SY
authors.lastname: Ryu
authors.forename: M H
authors.initials: MH
authors.lastname: Oak
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects*; D002460:Cell Line; D005663:Furans; D019686:Lamiaceae / Q000737:chemistry*; D008407:Mast Cells / Q000187:drug effects* / Q000201:enzymology; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D011809:Quinones; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D005663:Furans; D010616:Phenanthrenes; D010936:Plant Extracts; D011809:Quinones; C000713095:dihydrotanshinone I; C037886:cryptotanshinone; D001619:beta-N-Acetylhexosaminidases