A case of small cerebral cyst and pericentric inversion of chromosome 9 that developed schizophrenia-like psychosis.
A case of schizophrenia-like psychosis (psychotic disorder not otherwise specified according to the DSM-IV criteria) with pericentric inversion on chromosome 9 [inv.(9) (p11; q13)] is reported. In this case, a minor brain anomaly, a small cyst in the left subcortex, was observed on magnetic resonance imaging of the brain. In the clinical course, prominent chronic hallucinations were observed; however, there was no evidence of the disorganization of personality, delusion, and deterioration in level of functioning that are usually seen in schizophrenia. This case and a review of the literature indicate that the pericentric region of chromosome 9 might be a potential areas of interest for the aetiology of psychiatric disorders. The phenotype-karyotype relationship of pericentric inversion on chromosome 9 and its relationship to psychosis are discussed.
Miyaoka
T
T
Department of Psychiatry, Shimane Medical University, Izumo, Japan.
Seno
H
H
Itoga
M
M
Ishino
H
H
D000328:Adult; D001927:Brain Diseases / Q000150:complications / Q000235:genetics / Q000523:psychology*; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003560:Cysts / Q000150:complications / Q000235:genetics / Q000523:psychology*; D005260:Female; D006801:Humans; D011618:Psychotic Disorders / Q000209:etiology* / Q000235:genetics