title: Cholesteatoma in children.
abstract: Cholesteatoma in children is generally considered to be more aggressive and destructive than in adults. Each otologic surgeon has experienced widely extended cholesteatomas in children with large pneumatized mastoid processes. In this paper, we want to present clinical and experimental observations which imply that the destructive potential in children is similar to that in adults. Factors and observations that have led to the assumption that cholesteatoma in children is more aggressive will be discussed. Based on our experience and the literature, we tried to distill the current and leading thoughts concerning this intriguing entity.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Bochum, St. Elisabeth Hospital, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hildmann
authors.forename: H
authors.initials: H
authors.lastname: Sudhoff
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018424:Cholesteatoma, Middle Ear / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D002908:Chronic Disease; D004424:Ear Canal / Q000473:pathology; D004815:Epidermal Growth Factor / Q000032:analysis; D016222:Fibroblast Growth Factor 2 / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D019394:Ki-67 Antigen / Q000032:analysis; D010035:Otitis Media, Suppurative / Q000150:complications; D012867:Skin / Q000737:chemistry / Q000473:pathology; D016211:Transforming Growth Factor alpha / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D016211:Transforming Growth Factor alpha; D016222:Fibroblast Growth Factor 2; D004815:Epidermal Growth Factor