title: Low-protein overfeeding: a tool to unmask susceptibility to obesity in humans.
abstract: In search for an approach to identify physiological targets for therapeutic intervention in obesity management, we have revisited the classic human overfeeding studies of the 1960s, with new emphasis on a 'subgroup' of volunteers who were shifted between overfeeding on a typical affluent (normal-protein) diet and overfeeding on a low-protein diet. Following a re-analysis of these data, the arguments are put forward that since low-protein overfeeding is not only a potent stimulus of thermogenesis, but also an amplifier (or magnifier) of the small inter-individual variations in thermogenesis on the affluent (normal-protein) diet, it can be used as a tool to unmask some of the genetic and metabolic basis underlying human susceptibility to leanness and fatness.
authors.affiliation: Institute of Physiology, University of Fribourg, Rue du Musée 5, Switzerland. abdul.dulloo@unifr.ch
authors.forename: A G
authors.initials: AG
authors.lastname: Dulloo
authors.forename: J
authors.initials: J
authors.lastname: Jacquet
mesh_terms: D001833:Body Temperature Regulation; D018753:Diet, Protein-Restricted; D004198:Disease Susceptibility; D006801:Humans; D006963:Hyperphagia; D009765:Obesity / Q000209:etiology*; D015430:Weight Gain