Vaccines and passive immunological approaches for the control of fertility and hormone-dependent cancers.
Reviewed here is the development of a vaccine against the human chorionic gonadotropin that prevents pregnancy in sexually active women without impairment of ovulation or derangement of menstrual regularity. Also reviewed are the vaccines inducing antibodies against the luteinizing hormone-releasing hormone, which have immunotherapeutic potential in prostatic hypertrophy and other sex hormone-dependent male and female cancers. The adoption of passive immunization using humanized recombinant antihormone antibodies is advocated for assured efficacy and safe, prompt therapeutic action.
Talwar
G P
GP
International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India. gptalwar@del3.vsnl.net.in
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D006063:Chorionic Gonadotropin / Q000276:immunology*; D003269:Contraception, Immunologic / Q000379:methods*; D005193:Family Planning Services; D005260:Female; D005298:Fertility / Q000276:immunology; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D008297:Male; D011247:Pregnancy; D011470:Prostatic Hyperplasia / Q000517:prevention & control; D011471:Prostatic Neoplasms / Q000276:immunology / Q000517:prevention & control*; D013739:Testosterone / Q000276:immunology; D014612:Vaccines / Q000276:immunology*
D006063:Chorionic Gonadotropin; D014612:Vaccines; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone