[Value of p53, urokinase plasminogen activator, PAI-1 and Ki-67 in vulvar carcinoma].
OBJECTIVE
The present study was to measure new prognostic factors including the plasminogen activator urokinase and the plasminogen inhibitor PAI-1, as well as p53 and Ki-67, a marker of proliferation and to compare the clinical value of these in relation to the classic histopathological prognostic factors.


METHODS
The patient collective included 45 patients with vulvar carcinoma, both primary tumors and recurrences.


RESULTS
Highly significant correlations were found for tumor diameter and thickness. According to Kaplan-Meier estimations, the influence of thickness on the prognosis had a p-value of 0.048, while the influence of diameter had a p-value of 0.029. The variable grading was also significantly associated to the probability of survival (p = 0.01). There was no statistically significant correlation between p53 and the parameters grading, degree of keratinization and Ki-67 color index. The correlation between p53 and PAI-1 as well as between UPA and PAI-1 was highly significant. According to the Kaplan-Meier estimations, Ki-67, UPA and PAI-1 had no influence on survival in our group of patients.


CONCLUSIONS
For p53, the median value could be used as a divider with the median survival of patients with a p53 below 122 pg/mg protein being 151 months and with a p53 above 122 pg/mg being only 61 months. The corresponding p-value was significant at 0.0201.
Hoffmann
G
G
St. Josefs Hospital, Frauenklinik, Wiesbaden.
Casper
F
F
Weikel
W
W
Kümmerle
T
T
Pollow
B
B
Schaffrath
M
M
Hofmann
M
M
Pollow
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000401:mortality / Q000473:pathology*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D017395:Plasminogen Activator Inhibitor 1; D016159:Tumor Suppressor Protein p53; D014568:Urokinase-Type Plasminogen Activator
Untersuchungen zu p53, UPA, PAI-1 und Ki-67 beim Vulvakarzinom.