Changes in intestinal transit time after proctocolectomy assessed by the lactulose breath test.
After proctocolectomy with ileal pouch-anal anastomosis (IPAA) patients have increased stool frequency and intermittently use antidiarrheal medication. In addition to other factors, gastrointestinal transit time (MTT) could influence stool frequency. The aim of this study was to investigate how MTT changes after IPAA and to study whether MTT has an influence on daily stool frequency. In a prospective trial MTT was investigated with the lactulose breath test in 12 patients undergoing surgery for chronic ulcerative colitis (CUC) or familial adenomatous polyposis coli (FAPC) at different stages: before proctocolectomy, after IPAA with loop ileostomy, and 3 months and 1 year after ileostomy closure. MTT was also measured in 12 patients with IPAA, 12 patients with subtotal colectomy and ileorectal anastomosis (IRA), and 8 patients with conventional proctocolectomy and Brooke ileostomy (CPC) several years after surgery. Twelve healthy volunteers served as controls. Before IPAA, MTT was prolonged in CUC versus FAPC and controls. After restoration of gut continuity MTT was markedly accelerated. After 1 year MTT was slowed again, though values before proctocolectomy and those in controls were not reached. Several years after surgery MTT was significantly prolonged in IPAA and IRA versus controls. In CPC, MTT could not be determined by lactulose breath test. Stool frequency showed an inverse correlation to MTT in IPAA. In conclusion, this study shows that orocecal and oropouch transit are accelerated in the early postoperative period after (procto)colectomy but prolonged in the long-term course. Adaptation of the small bowel takes longer than 1 year. Impairment of stool frequency may be partly due to this adaptation.
Bruewer
M
M
Department of Surgery, University of Muenster, Waldeyerstrasse 1, 48149 Muenster, Germany.
Stern
J
J
Herrmann
S
S
Senninger
N
N
Herfarth
C
C
D011125:Adenomatous Polyposis Coli / Q000503:physiopathology / Q000601:surgery; D000328:Adult; D001944:Breath Tests / Q000379:methods; D003093:Colitis, Ulcerative / Q000503:physiopathology / Q000601:surgery; D016001:Confidence Intervals; D003672:Defecation; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007792:Lactulose / Q000032:analysis*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D016737:Proctocolectomy, Restorative; D011446:Prospective Studies; D013997:Time Factors
D007792:Lactulose