Selection of refractory and permissive strains of Aedes triseriatus (Diptera: Culicidae) for transovarial transmission of La Crosse virus.
The genetic basis of transovarial transmission of La Crosse virus in Aedes triseriatus (Say) was investigated through selection experiments on 2 mosquito strains. One strain was subject to selection for transovarial transmission refractoriness, the other for permissiveness to transovarial transmission. Response to selection for a low filial infection rate was rapid, decreasing from 18 to 3% in 3 generations. However, no response to selection for permissiveness was observed in the other strain; the average filial infection rates through 4 generations fluctuated between 25 and 40%. By contrast, the transovarial transmission rate in both strains showed a consistent response to selection in both directions. These patterns are consistent with a model in which transovarial transmission is controlled by a single genetic locus and permissiveness is conditioned by dominant alleles; whereas the filial infection rate is nongenetic and influenced by stochastic factors in the mosquito and virus.
Graham
D H
DH
Arthropod-Borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins 80523, USA.
Holmes
J L
JL
Higgs
S
S
Beaty
B J
BJ
Black
W C
WC
D000330:Aedes / Q000235:genetics / Q000821:virology*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004670:Encephalitis, California / Q000635:transmission*; D005260:Female; D018062:La Crosse virus / Q000502:physiology*; D007814:Larva / Q000821:virology; D008297:Male; D010053:Ovary / Q000821:virology; D013045:Species Specificity