Multi-system cytomegalovirus fetopathy by recurrent infection in a pregnant woman with hepatitis B.
A pregnant woman with acute hepatitis B virus (HBV) infection had her second pregnancy terminated at 25 weeks' gestation because of fetal ascites and ventriculitis. Meconium peritonitis was also found at autopsy. No HBV DNA but cytomegalovirus (CMV) DNA was detected in the fetal liver and ascitic fluid. Recurrent maternal CMV infection was demonstrated by pre-existing CMV IgG antibodies, high IgG avidity and low IgM levels. After abortion, the patient developed chronic active hepatitis. Nevertheless, having become pregnant again with a new partner, she had an uneventful third pregnancy and gave birth to a healthy boy.
Nigro
G
G
2nd Institute of Obstetrics and Gynecology and Pediatric Institute of La Sapienza University, Rome, Italy.
La Torre
R
R
Mazzocco
M
M
Coacci
F
F
Riosa
B
B
D'Emilio
C
C
Cosmi
E V
EV
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000196:embryology; D000032:Abortion, Therapeutic; D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001201:Ascites / Q000000981:diagnostic imaging / Q000196:embryology / Q000821:virology; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000196:embryology; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital* / Q000635:transmission; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000196:embryology / Q000821:virology*; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008099:Liver / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D016216:Ultrasonography, Prenatal
D000914:Antibodies, Viral; D004279:DNA, Viral