title: Development of patent Ascaris suum infections in pigs following intravenous administration of larvae hatched in vitro.
abstract: The normal tissue migration of Ascaris suum in the pig host involves larval development in the liver accompanied by considerable pathological changes. The vast majority of larvae that reach the small intestine are later expelled by unknown mechanisms. We show that when migration through the liver is bypassed by inoculation of pigs with an intravenous dose of larvae hatched in vitro, the larvae not only complete migration and return to the small intestine, but they also seem to have a greater chance of survival to adulthood. This technique offers new possibilities for studies on specific lung involvement in protective immunity, provides valuable information for the understanding of self cure by larval expulsion, and adds to our understanding of the evolution of migration of Ascaris larvae in tissues.
authors.affiliation: Department of Clinical Studies, Large Animal Medicine, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: G
authors.initials: G
authors.lastname: Jungersen
authors.forename: H P
authors.initials: HP
authors.lastname: Fagerholm
authors.forename: P
authors.initials: P
authors.lastname: Nansen
authors.forename: L
authors.initials: L
authors.lastname: Eriksen
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000469:parasitology / Q000473:pathology / Q000662:veterinary*; D017165:Ascaris suum / Q000254:growth & development / Q000472:pathogenicity*; D005243:Feces / Q000469:parasitology; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D007421:Intestine, Small / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008855:Microscopy, Electron, Scanning / Q000662:veterinary; D010270:Parasite Egg Count / Q000662:veterinary; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology* / Q000473:pathology