Action of the saliva of Triatoma infestans (Heteroptera: Reduviidae) on sodium channels.
Saliva of Triatoma infestans (Klug) produced a progressive reduction in the amplitude of the compound action potential recorded from rat sciatic nerve. The saliva also inhibited the Na+ current on GH3 cells. The data demonstrate that the saliva of T. infestans has an inhibitory effect on Na+ channels. We conclude that this effect may decrease the generation and conduction of nerve action potential, thereby decreasing the sensitivity of the region in which the insect probes, in a manner similar to that of local anesthetics. This study demonstrates such activity in the saliva of hematophagous insects. The adaptive value of this activity is clear, because the quantity of blood obtained by triatomines is limited by the irritation caused during the feeding process.
Dan
A
A
Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Pereira
M H
MH
Pesquero
J L
JL
Diotaiuti
L
L
Beirão
P S
PS
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002460:Cell Line; D051381:Rats; D017208:Rats, Wistar; D012463:Saliva / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology*; D014224:Triatoma / Q000502:physiology*
D015222:Sodium Channels