title: Decreased exhaled nitric oxide in mild persistent asthma patients treated with a leukotriene receptor antagonist, pranlukast.
abstract: Exhaled nitric oxide (NO) level decreases after corticosteroid treatment in asthmatics, but the effect of a leukotriene receptor antagonist, pranlukast, on exhaled NO has not been elucidated. Pranlukast treatment in mild persistent asthmatics for 4 weeks decreased the exhaled NO level, which did not differ from the levels in healthy subjects.
authors.affiliation: Department of Medicine, School of Medicine, Kitasato University, Sagamihara, 228-8555, Japan. hiro@kitasato-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Mitsufuji
authors.forename: R
authors.initials: R
authors.lastname: Hataishi
authors.forename: T
authors.initials: T
authors.lastname: Cui
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Tomita
mesh_terms: D000328:Adult; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism*; D002867:Chromones / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D018077:Receptors, Leukotriene / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D002867:Chromones; D020024:Leukotriene Antagonists; D018077:Receptors, Leukotriene; D009569:Nitric Oxide; C047681:pranlukast