Amifostine--a radioprotector in locally advanced head and neck tumors.
OBJECTIVE
There are some preliminary informations about the beneficial use of amifostine in avoiding side effects in patients with head and neck tumors who underwent radiotherapy.


METHODS
Amifostine was given as daily intravenous application (500 mg) 10 to 15 minutes prior to radiotherapy in 20 patients. The results were compared with another collective of patients which was similar.


RESULTS
According to the WHO score mucositis became manifest in 10 patients (Grade I) and 4 patients (Grade II) in the amifostine group vs 9 patients (Grade II), 6 patients (Grade III) and 1 patient (Grade IV) in the control group. Xerostomia has been seen in 15 patients (Grade I) and 5 patients (Grade II) after administration of amifostine. Without the drug 2 patients suffered from xerostomia (Grade I), 8 patients (Grade II) and 8 patients (Grade III), respectively. Administering amifostine had been feasible and non problematic. Only a small rate of toxic side effects like nausea (11%) or emesis (4%) was documented.


CONCLUSIONS
Amifostine is an effective radioprotector decreasing acute and late side effects in patients with head and neck tumors.
Schönekäs
K G
KG
Paracelsus-Strahlenklinik, Osnabrück, Germany. drkgs@aol.com
Wagner
W
W
Prott
F J
FJ
D000328:Adult; D000368:Aged; D004999:Amifostine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003680:Deglutition Disorders / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011182:Postoperative Care; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011855:Radiodermatitis / Q000209:etiology / Q000517:prevention & control; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012469:Salivary Glands / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014987:Xerostomia / Q000209:etiology / Q000517:prevention & control
D011837:Radiation-Protective Agents; D004999:Amifostine