title: Lung biopsy: is it necessary?
abstract: OBJECTIVE
  Lung biopsy is associated with substantial mortality rates. We reviewed our experience with this operation, primarily in patients with immunocompetence, to determine whether the results justify the continued performance of this procedure.
  
  
  METHODS
  We conducted a retrospective review of all diagnostic lung biopsies performed at 3 university-affiliated hospitals between July 1, 1992, and December 31, 1998.
  
  
  RESULTS
  There were 75 patients: 25 patients were treated electively, 17 were treated on an urgent basis, 27 patients on an emergency basis, and the urgency was unclear in 6 patients. Significant beneficial therapeutic changes were made in 15 of 25 elective procedures (60%), in 16 of 17 urgent procedures (94%), and in 11 of 27 emergency procedures (41%; P =.001). Significant beneficial therapeutic changes consisted of immunosuppression in 13 of 15 (87%) patients treated on an elective basis, in 9 of 16 (56%) treated on an urgent basis, and in 9 of 11 (82%) treated on an emergency basis in whom therapy was altered (P =.14). Operative death was 0 of 25 for elective operations (0%), 3 of 17 for urgent operations (18%), and 14 of 26 for emergency operations (54%). Multivariable analysis of operative death showed urgency to be the only significant predictor of death (P =.002).
  
  
  CONCLUSIONS
  In patients with immunocompetence, elective and urgent lung biopsies have acceptable operative mortality rates and frequently result in important beneficial therapeutic changes. Consequently biopsies are appropriate in these patients. Emergency biopsies are associated with high operative mortality rates and rarely result in a therapeutic change other than immunosuppression. These patients should not undergo lung biopsy if they are in stable condition and should be treated empirically with immunosuppression without operation if their condition is deteriorating.
authors.affiliation: University of New Mexico Health Sciences Center, Department of Surgery, Albuquerque, NM 87131, USA. Ttemes@salud.unm.edu
authors.forename: R T
authors.initials: RT
authors.lastname: Temes
authors.forename: N E
authors.initials: NE
authors.lastname: Joste
authors.forename: C R
authors.initials: CR
authors.lastname: Qualls
authors.forename: N L
authors.initials: NL
authors.lastname: Allen
authors.forename: R E
authors.initials: RE
authors.lastname: Crowell
authors.forename: H A
authors.initials: HA
authors.lastname: Dox
authors.forename: J A
authors.initials: JA
authors.lastname: Wernly
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002423:Cause of Death; D002648:Child; D004630:Emergencies; D005260:Female; D005544:Forecasting; D006801:Humans; D007121:Immunocompetence; D007165:Immunosuppression Therapy; D016015:Logistic Models; D008168:Lung / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012131:Respiratory Insufficiency / Q000175:diagnosis; D012189:Retrospective Studies; D015996:Survival Rate