title: SMART: a web-based tool for the study of genetically mobile domains.
abstract: SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.
authors.affiliation: EMBL, Meyerhofstrasse1, 69012 Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Schultz
authors.forename: R R
authors.initials: RR
authors.lastname: Copley
authors.forename: T
authors.initials: T
authors.lastname: Doerks
authors.forename: C P
authors.initials: CP
authors.lastname: Ponting
authors.forename: P
authors.initials: P
authors.lastname: Bork
mesh_terms: D003628:Database Management Systems; D016247:Information Storage and Retrieval; D020407:Internet; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment
chemical_list: D011506:Proteins