Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice.
Morphine (10 and 20 mg/kg, s.c.) does not modify dopamine release in the nucleus accumbens of cannabinoid CB(1) knock-out mice under conditions where it dose-dependently stimulates the release of dopamine in the corresponding wild-type mice. These results demonstrate that cannabinoid CB(1) receptors, regulate mesolimbic dopaminergic transmission in brain areas known to be involved in the reinforcing effects of morphine.
Mascia
M S
MS
Department of Neuroscience, <<B.B. Brodie>> University of Cagliari, 09124, Cagliari, Italy.
Obinu
M C
MC
Ledent
C
C
Parmentier
M
M
Böhme
G A
GA
Imperato
A
A
Fratta
W
W
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009020:Morphine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D000701:Analgesics, Opioid; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D009020:Morphine; D004298:Dopamine