title: MTA, a novel multitargeted antifolate, from preclinical to phase I and beyond: summary and conclusions.
authors.affiliation: Department of Oncology, University of Newcastle upon Tyne, UK.
authors.forename: H
authors.initials: H
authors.lastname: Calvert
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D005971:Glutamates / Q000627:therapeutic use*; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D000068437:Pemetrexed; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D013940:Thymidylate Synthase