Artificial cell microcapsules containing genetically engineered E. coli DH5 cells for in-vitro lowering of plasma potassium, phosphate, magnesium, sodium, chloride, uric acid, cholesterol, and creatinine: a preliminary report.
Lowering of plasma Mg, P, Na, Cl, uric acid, cholesterol, and creatinine is required in renal failure and other diseases. In this preliminary report, we studied the ability of artificial cells microencapsulated genetically engineered E. coli DH5 cells in lower K, Mg, P, Na, Cl, uric acid, cholestrol, creatinine, and billirubin from plasma in-vitro. Result shows that this novel approach has the ability to significantly lower these metabolites from the plasma in-vitro.
Prakash
S
S
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Chang
T M
TM
D000818:Animals; D018533:Biomass; D002214:Capsules; D002712:Chlorides / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D003404:Creatinine / Q000097:blood*; D004573:Electrolytes / Q000097:blood*; D004926:Escherichia coli / Q000166:cytology*; D005818:Genetic Engineering; D008274:Magnesium / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D010710:Phosphates / Q000097:blood; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D014510:Urease / Q000378:metabolism; D014527:Uric Acid / Q000097:blood*
D002214:Capsules; D002712:Chlorides; D004573:Electrolytes; D008567:Membranes, Artificial; D010710:Phosphates; D014527:Uric Acid; D002784:Cholesterol; D012964:Sodium; D003404:Creatinine; D014510:Urease; D008274:Magnesium; D011188:Potassium