title: Diastereoselective Synthesis of C-Glycosylated Amino Acids with Lactams as Peptide Building Blocks.
abstract: Readily available by lipase-catalyzed kinetic resolution or from a chiral pool, beta-, gamma-, and delta-lactams can be used as peptide building blocks for the synthesis of C-glycosylated amino acids 1. By reaction with glycosyl dianions, metabolic stable glycosylated amino acids can be prepared diastereoselectively. Ac=acetyl; Bn=benzyl; Boc=tert-butoxycarbonyl; R=Et, Bn; R'=H, alkyl; n=1-3.
authors.affiliation: Fachbereich für Chemie und Chemietechnik der Universität-Gesamthochschule, Warburgerstrasse 100, D-33098 Paderborn (Germany).
authors.initials: B
authors.lastname: Westermann
authors.initials: A
authors.lastname: Walter
authors.initials: N
authors.lastname: Diedrichs