title: Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
abstract: The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.
authors.affiliation: DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA.
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: J D
authors.initials: JD
authors.lastname: Rodgers
authors.forename: R J
authors.initials: RJ
authors.lastname: McHugh
authors.forename: B L
authors.initials: BL
authors.lastname: Johnson
authors.forename: B C
authors.initials: BC
authors.lastname: Cordova
authors.forename: R M
authors.initials: RM
authors.lastname: Klabe
authors.forename: L T
authors.initials: LT
authors.lastname: Bacheler
authors.forename: S
authors.initials: S
authors.lastname: Erickson-Viitanen
authors.forename: S S
authors.initials: SS
authors.lastname: Ko
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D016333:HIV Protease / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D014508:Urea; D016333:HIV Protease