title: Levothyroxine-induced liver dysfunction in a primary hypothyroid patient.
abstract: Here we report a case of levothyroxine-induced liver dysfunction. T4 (levothyroxine) has been more commonly used for the treatment of hypothyroidism than T3 active hormone (triiodothyronine), because with the former drug a stabler plasma concentration is obtained after oral administration. Although there are few reports on levothyroxine-induced liver dysfunction, we treated a primary hypothyroid patient with high serum aminotransferase after administration of levothyroxine. Liver dysfunction was improved after cessation of the drug administration. Antibody to T4 was found in the serum of the patient after this event. From clinical course and laboratory data of the patient, the episode of liver damage was considered to be induced by levothyroxine. We then administrated triiodothyronine, and it did not induce liver dysfunction. Changing levothyroxine to triiodothyronine resulted in a successful clinical course in this case, as re-administration of the doubtful drug is strictly limited.
authors.affiliation: Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohmori
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Tsuruoka
authors.forename: K
authors.initials: K
authors.lastname: Sugimoto
authors.forename: E
authors.initials: E
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
mesh_terms: D000293:Adolescent; D000920:Antibody-Dependent Cell Cytotoxicity; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D013974:Thyroxine / Q000009:adverse effects*; D014284:Triiodothyronine / Q000627:therapeutic use
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine