title: Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl]- 3,5-pyridine dicarboxylate.
abstract: The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum.
authors.affiliation: Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tunçbilek
authors.forename: S
authors.initials: S
authors.lastname: Ozbey
authors.forename: E
authors.initials: E
authors.lastname: Kendi
authors.forename: E
authors.initials: E
authors.lastname: Yildirim
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: R
authors.initials: R
authors.lastname: Ertan
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D014961:X-Ray Diffraction
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C403050:dimethyl-1,4-dihydro-2,6-dimethyl-4-(4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl)-3,5-pyridine dicarboxylate; C038806:1,4-dihydropyridine