In vivo abnormal keratinazation in Darier-White's disease as viewed by real-time confocal imaging.
Darier-White's disease is a rare autosomal-dominant disorder of keratinization. The underlying pathology for the clinical presentation is acantholysis, and various types of dyskeratosis and acanthosis. In this study, we utilized a non-invasive optical imaging modality, confocal reflectance microscopy, to identify specific histologic features of Darier-White's disease in vivo. Micrographic findings in the confocal images were corps ronds, suprabasal clefts, acantholytic suprabasal keratinocytes, and villi. Real-time confocal images are illustrative and can be well correlated with known light microscopic phenomena, particularly in the case of keratinization abnormalities in Darier-White's disease.
González
S
S
Dermatology Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA. gonzalsa@helix.mgh.harvard.edu
Rubinstein
G
G
Mordovtseva
V
V
Rajadhyaksha
M
M
Anderson
R R
RR
D007644:Darier Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology*; D007633:Keratins / Q000378:metabolism; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods; D008875:Middle Aged; D012867:Skin / Q000378:metabolism / Q000473:pathology*
D007633:Keratins