[Effect of liver hydrolysate on hepatic proliferation in regenerating rat liver].
The effect of liver hydrolysate (LH) derived from bovine liver on rat liver regeneration after partial hepatectomy (PH) were investigated. Oral administration of LH increased rat liver weight dose-dependently at 24 h after PH. Hepatic ornithine decarboxylase (ODC) activity and proliferating cell nuclear antigen (PCNA) labeling index were measured in regenerating rat liver as markers of cell proliferation. ODC activities at 4 and 24 h after PH were significantly increased by LH administration. PCNA labeling index at 24 h after PH were also increased by LH administration. These results suggest that LH stimulates liver regeneration in partially hepatectomized rats.
Fukuda
Y
Y
Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
Sawata
M
M
Washizuka
M
M
Higashino
R
R
Fukuta
Y
Y
Tanaka
Y
Y
Takei
M
M
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006498:Hepatectomy; D008099:Liver / Q000737:chemistry* / Q000166:cytology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011492:Protein Hydrolysates / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013268:Stimulation, Chemical; D013997:Time Factors
D018809:Proliferating Cell Nuclear Antigen; D011492:Protein Hydrolysates; D009955:Ornithine Decarboxylase