Bcl10 in chronic lymphocytic leukaemia and T-cell prolymphocytic leukaemia.
Bcl10 is a cancer gene recently identified in B-cell lymphomas of mucosa-associated lymphoid tissues. It has been suggested as a target for mutation in multiple types of tumour including follicular lymphoma, T-cell acute lymphoblastic leukaemia and Sezary syndrome. To evaluate further the role of Bcl10 in human adult haematological cancers, we screened for mutations samples from 24 patients with B-cell chronic lymphocytic leukaemia (CLL) and 18 samples from patients with T-cell prolymphocytic leukaemia (T-PLL). No pathogenic mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not involved in the development of CLL or T-PLL and that its involvement may be restricted to other haematological malignancies.
Yuille
M R
MR
Academic Department of Haematology and Cytogenetics, Institute of Cancer Research, Sutton, Surrey. myuille@icr.ac.uk
Stone
J G
JG
Bradshaw
P S
PS
Houlston
R S
RS
D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D000074018:B-Cell CLL-Lymphoma 10 Protein; D005091:Exons; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D015463:Leukemia, Prolymphocytic / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D009363:Neoplasm Proteins