title: [Efficiency of polysaccharide translam for early treatment of acute radiation illness].
abstract: Antiradiation therapeutic efficiency of translam (1-->3; 1-->6-beta-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD90). The preparation is nontoxic and has a broad therapeutic range which permits its practical application.
authors.affiliation: State Research Centre of Russia-Institute of Biophysics, Moscow. ibphgen@rcibph.dol.ru
authors.forename: K S
authors.initials: KS
authors.lastname: Chertkov
authors.forename: S A
authors.initials: SA
authors.lastname: Davydova
authors.forename: T A
authors.initials: TA
authors.lastname: Nesterova
authors.forename: T N
authors.initials: TN
authors.lastname: Zviagintseva
authors.forename: L A
authors.initials: LA
authors.lastname: Eliakova
mesh_terms: D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D005936:Glucans / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D000882:Haplorhini; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005936:Glucans; C033671:epiglucan
vernacular_title: Effektivnost' polisakharida translama kak sredstva rannego lecheniia ostroĭ luchevoĭ bolezni.