The activation of the tissue plasminogen activator-plasmin system induced in the mouse hippocampus after injection of trimethyltin: possible proteolysis of highly polysialylated NCAM.
Trimethyltin (TMT) is a neurotoxicant that causes the death of granule cells and degrades highly polysialylated NCAM (PSA-NCAM) in the dentate gyrus. To investigate the role of the tPA-plasmin system in the degradation of PSA-NCAM, we injected trimethyltin (TMT) into mice. As a result, tPA activity was significantly increased in CA1-CA4 and the dentate gyrus after TMT injection. These results suggest that up-regulated tPA may contribute to the degradation of PSA-NCAM.
Endo
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Departments of Dentistry and Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Hashimoto
K
K
Takada
Y
Y
Takada
A
A
D000818:Animals; D002364:Caseins / Q000378:metabolism; D018891:Dentate Gyrus / Q000187:drug effects / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D005341:Fibrinolysin / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D012794:Sialic Acids / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000378:metabolism*; D014298:Trimethyltin Compounds / Q000494:pharmacology*
D002364:Caseins; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; D014298:Trimethyltin Compounds; C021319:polysialic acid; C046488:trimethyltin; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin