title: A dictionary-based approach for gene annotation.
abstract: This paper describes a fast and fully automated dictionary-based approach to gene annotation and exon prediction. Two dictionaries are constructed, one from the nonredundant protein OWL database and the other from the dbEST database. These dictionaries are used to obtain O (1) time lookups of tuples in the dictionaries (4 tuples for the OWL database and 11 tuples for the dbEST database). These tuples can be used to rapidly find the longest matches at every position in an input sequence to the database sequences. Such matches provide very useful information pertaining to locating common segments between exons, alternative splice sites, and frequency data of long tuples for statistical purposes. These dictionaries also provide the basis for both homology determination, and statistical approaches to exon prediction.
authors.affiliation: Department of Mathematics, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: L
authors.initials: L
authors.lastname: Pachter
authors.forename: S
authors.initials: S
authors.lastname: Batzoglou
authors.forename: V I
authors.initials: VI
authors.lastname: Spitkovsky
authors.forename: E
authors.initials: E
authors.lastname: Banks
authors.forename: E S
authors.initials: ES
authors.lastname: Lander
authors.forename: D J
authors.initials: DJ
authors.lastname: Kleitman
authors.forename: B
authors.initials: B
authors.lastname: Berger
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D016208:Databases, Factual; D004014:Dictionaries as Topic; D005091:Exons; D020224:Expressed Sequence Tags; D005796:Genes; D005821:Genetic Techniques; D006801:Humans; D011506:Proteins / Q000235:genetics; D016415:Sequence Alignment / Q000706:statistics & numerical data; D012984:Software
chemical_list: D011506:Proteins