Multiple roles for Src in a PDGF-stimulated cell.
The observation that platelet-derived growth factor (PDGF) increases the catalytic activity of Src family members (Src) suggests that they contribute to PDGF-dependent responses. The role of Src in PDGF-dependent cell cycle progression, phosphorylation of proteins, and chemotaxis has been tested by investigators using a variety of cell types and approaches, and it appears that the contribution of Src is highly variable. This idea is perhaps best illustrated by the finding that Src plays radically different roles downstream of the PDGF alpha- and beta-receptor subunits. Hence, Src is a versatile signal relay enzyme, whose contribution to a signaling cascade depends on variables such as the nature of the receptor via which the cell is activated, as well as the cell type itself.
DeMali
K A
KA
Schepens Eye Research Institute, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, 02114, USA.
Godwin
S L
SL
Soltoff
S P
SP
Kazlauskas
A
A
D002453:Cell Cycle; D002633:Chemotaxis; D010766:Phosphorylation; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D019061:src-Family Kinases / Q000378:metabolism*
D010982:Platelet-Derived Growth Factor; D019061:src-Family Kinases