Long-term treatment of streptozotocin-induced diabetes by continuous insulin minipump in the Syrian hamster.
It is difficult to normalize plasma glucose for a prolonged period of time by s.c. injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a s.c.-implanted osmotic minipump. The pumps, which release insulin at a constant rate, were replaced every 14 days with fresh pumps for as long as 52 days. A high insulin dose (1 U/kg/h) was required to normalize plasma glucose and fatty acid concentrations, water and food consumption, urine output, and body weight.
Fisher
W E
WE
Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D006224:Cricetinae; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D015918:Infusion Pumps, Implantable; D007332:Insulin Infusion Systems; D008297:Male; D008647:Mesocricetus
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified