title: Esophageal tuberculosis. Endoscopic cytology as a diagnostic tool.
abstract: OBJECTIVE
  To study the utility of endoscopic cytology in the diagnosis of esophageal tuberculosis in clinically unsuspected cases.
  
  
  METHODS
  During a period of four years, endoscopic cytology of esophageal lesions was performed on 228 patients. In eight (3.5%) the cytologic diagnosis of esophageal tuberculosis was suggested on smears. Upon endoscopic examination, the sites of involvement were mid esophagus (five cases), upper esophagus (two cases) and lower esophagus (one case). Linear ulcer was seen in six cases; growth and narrowing of the lumen were seen in one case each. Endoscopic brush smears in seven cases and fine needle aspiration cytology smear in one case were collected. Air-dried smears stained by Giemsa stain were reviewed for detailed cytologic assessment.
  
  
  RESULTS
  Smears showed well-defined granulomas with necrosis in five cases and granulomas without necrosis in three. Cytologic evidence of concurrent poorly differentiated squamous cell carcinoma was observed in one case. Tubercle bacilli were demonstrated in five cases. Endoscopic biopsy showed granulomas in three cases and tubercle bacilli in one case. In six cases there was no clinical or radiologic evidence of tuberculosis at other sites, thereby suggesting the possibility of primary esophageal tuberculosis. The remaining two cases had a past history of tuberculosis; one presented with cervical lymphadenopathy and one mediastinal lymphadenopathy. All patients received antitubercular treatment, and the patient with concurrent malignancy also received radiotherapy. All but one of the patients who succumbed to aspiration pneumonia responded to treatment.
  
  
  CONCLUSIONS
  Endoscopic cytology is a useful modality in the diagnosis of esophageal tuberculosis in clinically unsuspected cases.
authors.affiliation: Department of Pathology and Medicine, Maulana Azad Medical College, New Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: D K
authors.initials: DK
authors.lastname: Das
authors.forename: S K
authors.initials: SK
authors.lastname: Jain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016145:Endoscopy, Digestive System; D004935:Esophageal Diseases / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000473:pathology; D006801:Humans; D009336:Necrosis; D014376:Tuberculosis / Q000473:pathology*