title: Enalapril (10 mg/day) in systemic sclerosis. One year, double blind, randomised study (ESS-1): echocardiographic substudy--three months follow-up.
abstract: The ESS-1 study was designed to evaluate the long-term effects of the angiotensin converting enzyme inhibitor (ACEI) enalapril (10 mg per day) on the cardio-pulmonary system in patients with scleroderma (SSc). We estimated changes in heart diameters, systolic and diastolic left ventricle function and mean values of pulmonary artery pressure after 3 months treatment. The study group comprise 41 patients with SSc. 18 patients received placebo and 23 ones were given enalapril. After 3 months of treatment we did not observe statistically significant differences in heart diameters and left ventricle systolic function parameters between treated group and placebo. Enalapril therapy did not affect left ventricle diastolic function, nevertheless differences in MVA were almost of statistical significance. Echocardiographic signs of pulmonary hypertension were found in 4 patients.
authors.affiliation: I Department of Internal Medicine, University School of Medicine, Lublin, Poland. anbil@eskulap.am.lublin.pl
authors.forename: A
authors.initials: A
authors.lastname: Biłan
authors.forename: M
authors.initials: M
authors.lastname: Chibowska
authors.forename: B
authors.initials: B
authors.lastname: Makaruk
authors.forename: R
authors.initials: R
authors.lastname: Palusiński
authors.forename: J
authors.initials: J
authors.lastname: Weglarz
authors.forename: S
authors.initials: S
authors.lastname: Ostrowski
authors.forename: A
authors.initials: A
authors.lastname: Witczak
authors.forename: J
authors.initials: J
authors.lastname: Hanzlik
authors.forename: D
authors.initials: D
authors.lastname: Krasowska
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004452:Echocardiography; D004656:Enalapril / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril