title: Amyloid beta peptide membrane perturbation is the basis for its biological effects.
abstract: Experimental studies have indicated that the mechanisms offered for explaining the neurotoxicity of amyloid beta peptide (AbetaP) are diverse, and include altered enzyme activities, disrupted calcium homeostasis, and increased free radical formation. AbetaP appears to interact at the cell membrane with a multitude of receptor sites and also inserts physically into the membrane matrix. This membrane insertion affects the membrane fluidity and potentially influences the function of resident membrane proteins. We propose a unifying hypothesis to explain the experimental observations of the diverse cellular responses to AbetaP. The indiscriminate physical insertion of AbetaP into the cell membrane unspecifically activates a host of membrane processes by perturbation of the membrane proteins. This recurrent activation of membrane processes eventually culminates in neuronal cell death. We recommend that successful therapeutic interventions should be directed at reducing or preventing the interaction of AbetaP with neuronal cell membranes.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.
authors.forename: J N
authors.initials: JN
authors.lastname: Kanfer
authors.forename: G
authors.initials: G
authors.lastname: Sorrentino
authors.forename: D S
authors.initials: DS
authors.lastname: Sitar
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology* / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008560:Membrane Fluidity / Q000502:physiology; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009498:Neurotoxins
chemical_list: D016229:Amyloid beta-Peptides; D008565:Membrane Proteins; D009498:Neurotoxins