Measuring neuroleptic-induced akathisia by three-channel actometry.
Three-channel actometry was used to study neuroleptic-induced akathisia (NIA), a common and often serious disorder in association of traditional neuroleptic therapy. The aim was to explore the diagnostic possibilities of actometry in NIA and to examine in detail the motor phenomenology of the disorder in detail. The actometers were attached to the ankles and waists of ten patients, suffering from NIA, and to ten matched healthy controls. Five of the patients were changed to olanzapine treatment, and these patients were re-examined during the no-NIA condition. NIA was associated with manyfold movement activity during controlled rest (sitting) but not with increased daily overall motor activity. Movement frequencies in NIA seemed to be pathognomonic. Actometry is promising for investigation and clinical assessment of NIA. Olanzapine proved to be an adequate treatment choice for NIA patients.
Tuisku
K
K
Department of Psychiatry, University of Helsinki, Finland. katinka.tuisku@huch.fi
Lauerma
H
H
Holi
M
M
Markkula
J
J
Rimon
R
R
D000328:Adult; D017109:Akathisia, Drug-Induced / Q000175:diagnosis* / Q000503:physiopathology*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007734:Kymography; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects*; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000503:physiopathology; D012720:Severity of Illness Index
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine