title: Effectiveness of pneumococcal polysaccharide vaccine for preschool-age children with chronic disease.
abstract: To estimate the effectiveness of pneumococcal polysaccharide vaccine, we serotyped isolates submitted to the Pneumococcal Sentinel Surveillance System from 1984 to 1996 from 48 vaccinated and 125 unvaccinated children 2 to 5 years of age. Effectiveness against invasive disease caused by serotypes included in the vaccine was 63%. Effectiveness against serotypes in the polysaccharide vaccine but not in a proposed seven-valent protein conjugate vaccine was 94%.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. abf4@cdc.gov
authors.forename: A E
authors.initials: AE
authors.lastname: Fiore
authors.forename: O S
authors.initials: OS
authors.lastname: Levine
authors.forename: J A
authors.initials: JA
authors.lastname: Elliott
authors.forename: R R
authors.initials: RR
authors.lastname: Facklam
authors.forename: J C
authors.initials: JC
authors.lastname: Butler
mesh_terms: D001428:Bacterial Vaccines; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D018571:Sentinel Surveillance; D012703:Serotyping; D012805:Sickle Cell Trait; D013296:Streptococcus pneumoniae / Q000145:classification*; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines