Erythroid Kruppel like factor: from fishing expedition to gourmet meal.
Erythroid Kruppel like factor (EKLF) is the founding member of a family of transcription factors which are defined by the presence of three C-terminal C2H2-type zinc fingers. Since its discovery 6 years ago, the study of EKLF has been intense. In this review I will revisit the discovery of EKLF, and highlight recent advances in our understanding of how it interacts with other proteins to regulate erythroid gene transcription. The current knowledge of the biological role/s of EKLF in erythroid cell differentiation and globin gene switching are summarized.
Perkins
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Department of Physiology, Monash University, Clayton, Victoria, Australia.
D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D004920:Erythropoiesis / Q000502:physiology; D005544:Forecasting; D005786:Gene Expression Regulation; D006801:Humans; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D008969:Molecular Sequence Data; D010766:Phosphorylation; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014161:Transduction, Genetic
D004268:DNA-Binding Proteins; C096161:KLF2 protein, human; C501168:KLF3 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; D015534:Trans-Activators; D014157:Transcription Factors; C080774:erythroid Kruppel-like factor