title: Sperm quality may adversely affect the chromosome constitution of embryos that result from intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To determine whether the high rate of chromosomal abnormalities in the embryos of an infertile couple were caused by a paternal factor that may have involved the sperm centriole.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Private IVF program.
  
  
  METHODS
  An infertile couple who underwent IVF-ET because of severe male factor infertility and endometriosis.
  
  
  METHODS
  Preimplantation genetic diagnosis of chromosomal abnormalities in embryos derived from two cycles of ICSI in which the husband's sperm was used and one in which donor sperm was used.
  
  
  METHODS
  Preimplantation genetic diagnosis with fluorescence in situ hybridization using probes for chromosomes X, Y, 13, 16, 18, and 21, and determination of hCG levels.
  
  
  RESULTS
  Most of the embryos derived from the cycles in which the husband's sperm was used were chromosomally abnormal (82%), whereas all the embryos derived from the cycle in which donor sperm was used were chromosomally normal. The cycle in which donor sperm was used resulted in an ongoing pregnancy.
  
  
  CONCLUSIONS
  Paternal factors, which most likely derive from the centrosome, can contribute to numerical chromosomal abnormalities, which in turn may predispose to implantation failure.
authors.affiliation: New York Fertility Institute, New York 10028, USA. obasaju@msn.com
authors.forename: M
authors.initials: M
authors.lastname: Obasaju
authors.forename: A
authors.initials: A
authors.lastname: Kadam
authors.forename: K
authors.initials: K
authors.lastname: Sultan
authors.forename: M
authors.initials: M
authors.lastname: Fateh
authors.forename: S
authors.initials: S
authors.lastname: Munné
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011785:Quality Assurance, Health Care; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000648:ultrastructure*