title: Invasion of the lacrimal system by basal cell carcinoma.
abstract: BACKGROUND
  The rate of recurrence of basal cell carcinoma (BCC) in the periorbital region is higher than that in other areas because of the spread of the tumor along barrier structures.
  
  
  OBJECTIVE
  A better understanding of the biological behavior of BCC in this area, in particular as it relates to the lacrimal system, should improve the outcome of surgery.
  
  
  METHODS
  A study was made of two cases of BCC that developed in the periorbital region and invaded the lacrimal system.
  
  
  RESULTS
  The tumors were found to have invaded the lacrimal system along the mucosal epithelium. Magnetic resonance imaging (MRI) did not suggest any abnormalities in this area. In one patient, the tumor had infiltrated the nasal cavity without destruction of the periorbital bone and nasal cartilage. A preoperative fiberscopic examination clearly demonstrated the involvement of the nasal cavity in this case.
  
  
  CONCLUSIONS
  The lacrimal system is often invaded by BCC that originates from the periorbital region. Physicians and surgeons need to be well aware of the possibility of such aggressive infiltration by BCC.
authors.affiliation: Department of Dermatology, Oita Medical University, Oita, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hatano
authors.forename: H
authors.initials: H
authors.lastname: Terashi
authors.forename: S
authors.initials: S
authors.lastname: Kurata
authors.forename: Y
authors.initials: Y
authors.lastname: Asada
authors.forename: H
authors.initials: H
authors.lastname: Shibuya
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Tada
authors.forename: S
authors.initials: S
authors.lastname: Fujiwara
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Kurono
authors.forename: S
authors.initials: S
authors.lastname: Takayasu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000628:therapy; D005134:Eye Neoplasms / Q000556:secondary*; D005142:Eyelid Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000473:pathology*; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy