title: Hepatitis A in Latin America: a changing epidemiologic pattern.
abstract: In a multicenter study, hepatitis A virus (HAV) seroprevalence was surveyed in six countries in Latin America in which in 12,000 subjects were stratified for age. The highest rates of seroprevalence were recorded in the Dominican Republic (89.0%) and Mexico (81.0%), with lower rates in Brazil (64.7%), Chile (58.1%), Venezuela (55.7%), and Argentina (55.0%). The seroprevalence of HAV in children between 1 and 5 years of age was less than 50%, except in the Dominican Republic. In the 5-10-year-old age group, seroprevalence rates have also decreased compared with previous reports. This suggests that the epidemiology is shifting from high to intermediate endemicity, with the population susceptible to HAV infection shifting from children to adolescents and adults. Furthermore, data from Brazil, Argentina, and Mexico show that HAV seroprevalence is significantly lower in people living in medium and high socioeconomic conditions. This study suggests the need for appropriate vaccination programs to be implemented targeting children, adolescents, and adults, particularly in higher socioeconomic groups.
authors.affiliation: Prevención y Control de Enfermedades, Secretaria de Salud, Colonia Juárez, Mexico City, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Tapia-Conyer
authors.forename: J I
authors.initials: JI
authors.lastname: Santos
authors.forename: A M
authors.initials: AM
authors.lastname: Cavalcanti
authors.forename: E
authors.initials: E
authors.lastname: Urdaneta
authors.forename: L
authors.initials: L
authors.lastname: Rivera
authors.forename: A
authors.initials: A
authors.lastname: Manterola
authors.forename: M
authors.initials: M
authors.lastname: Potin
authors.forename: R
authors.initials: R
authors.lastname: Ruttiman
authors.forename: J
authors.initials: J
authors.lastname: Tanaka Kido
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology*; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007843:Latin America / Q000453:epidemiology; D008297:Male; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D012923:Social Class
chemical_list: D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies