Unsymmetrical cyclic ureas as HIV-1 protease inhibitors: novel biaryl indazoles as P2/P2' substituents.
The preparation of unsymmetrical cyclic ureas bearing novel biaryl indazoles as P2/P2' substituents was undertaken, utilizing a Suzuki coupling reaction as the key step. Compound 6i was equipotent to the lead compound of the series SE063.
Patel
M
M
DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA.
Rodgers
J D
JD
McHugh
R J
RJ
Johnson
B L
BL
Cordova
B C
BC
Klabe
R M
RM
Bacheler
L T
LT
Erickson-Viitanen
S
S
Ko
S S
SS
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D016333:HIV Protease / Q000187:drug effects; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000201:enzymology; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D014508:Urea; D016333:HIV Protease