Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit.
In the course of our analysis of genomic sequence from the human chromosome 4p16.1 region harboring both the Wolfram and Ellis van Creveld syndrome genes we have identified a sequence with high homology (98% at the amino acid level) to the rat cDNA coding for the protein phosphatase 2A BRgamma (PP2ABRgamma) regulatory subunit. Although the human cDNAs for both the BRalpha and BRbeta isoforms have been described previously, the BRgamma subunit has not yet been identified in humans. Here we describe the precise genomic organization and genetic localization of the human PP2ABRgamma gene.
Torres
R
R
Novartis Pharmaceuticals Corporation, Pharmacogenetics Division, Gaithersburg, MD 20878, USA.
Ide
S E
SE
Dehejia
A
A
Baras
A
A
Polymeropoulos
M H
MH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D020451:Contig Mapping; D005091:Exons / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000235:genetics*; D054648:Protein Phosphatase 2; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA
D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2