[Regulation of the mitotic activity in the rat cornea in response to protective and therapeutic effects of para-aminobenzoic acid in experiments with roentgen radiation].
The protective and therapeutic action of p-aminobenzoic acid (PABA), at doses effective in interferon induction (Akberova et al., 1999), was studied on the rat cornea in the experiments with X-irradiation (5 Gy). PABA at 10 mg/kg preserved the postradiation mitotic activity at the level of irradiated control, while at 1.4 and 100 mg/kg it increased the mitotic activity above the control level. In all experiments, PABA at all three doses decreased the rate of pathological mitoses in equal proportions to the total number of mitoses.
Stroeva
O G
OG
Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Panova
I G
IG
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000818:Animals; D003315:Cornea / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D007369:Interferon Inducers / Q000494:pharmacology*; D008297:Male; D008938:Mitosis / Q000187:drug effects* / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007369:Interferon Inducers; D011837:Radiation-Protective Agents; D010129:4-Aminobenzoic Acid
Reguliatsiia mitoticheskoĭ aktivnosti v rogovitse krys pri zashchitnom i lechebnom deĭstvii paraaminobenzoĭnoĭ kisloty v opytakh s rentgenovskim oblucheniem.