Lactoferrin: a multifunctional glycoprotein.
Lactoferrin is an iron-binding glycoprotein found in milk, exocrine secretions of mammals, and in secondary granules from polymorphonuclear neutrophils. This review describes the wide spectrum of functions ascribed to lactoferrin, with special emphasis on the antimicrobial properties of this protein, and its derived peptides.
Vorland
L H
LH
Department of Medical Microbiology, University Hospital and University of Tromsø, Norway.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D000935:Antifungal Agents / Q000378:metabolism; D000970:Antineoplastic Agents / Q000378:metabolism; D000981:Antiprotozoal Agents / Q000378:metabolism; D000998:Antiviral Agents / Q000378:metabolism; D002417:Cattle; D003167:Complement Activation; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006090:Gram-Negative Bacteria / Q000472:pathogenicity; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007781:Lactoferrin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008892:Milk / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D011134:Polysaccharides / Q000378:metabolism; D014018:Tissue Distribution; D014774:Virulence
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D000998:Antiviral Agents; D016207:Cytokines; D011134:Polysaccharides; D007501:Iron; D007781:Lactoferrin