Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease.
Evidence from in vitro studies suggests that gamma interferon (IFN-gamma) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with targeted disruption of the IFN-gamma receptor gene and mice with targeted disruption of the gene encoding inducible NO synthase to show that IFN-gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice.
Seydel
K B
KB
Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Smith
S J
SJ
Stanley
S L
SL
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004195:Disease Models, Animal; D004748:Entamoeba histolytica / Q000276:immunology / Q000472:pathogenicity; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D008101:Liver Abscess, Amebic / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016513:Mice, SCID; D009569:Nitric Oxide / Q000276:immunology*; D019001:Nitric Oxide Synthase / Q000172:deficiency / Q000235:genetics; D052247:Nitric Oxide Synthase Type II
D017931:DNA Primers; D009569:Nitric Oxide; D007371:Interferon-gamma; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse