title: Alumina powder/Bis-GMA composite: effect of filler content on mechanical properties and osteoconductivity.
abstract: Three composites consisting of alumina powder dispersed in a bisphenol-a-glycidyl methacrylate (Bis-GMA) matrix were prepared and evaluated to assess the effect of alumina powder content on the mechanical properties and osteoconductivity of the composite. The alumina powder composites (APC) consisted of alumina powder (AL-P) as the inorganic filler dispersed in a Bis-GMA matrix that was solidified by a radical polymerization process. Prior to polymerization the AL-P was mixed with the monomers in proportions of 50%, 70%, and 80% by weight (APC50, APC70, and APC80). A fused silica-glass-filled composite containing 70% glass by weight (SGC70) was used as a control. The compressive and bending strengths, the elastic modulus in bending, and the bending strain of the composites increased as the AL-P content increased. We also evaluated the composites in vivo by implanting them into the medullary canals of rat tibiae. To compare the osteoconductivity of the composites, an affinity index was calculated for each composite; the affinity index equals the length of a bone in direct apposition to the composite and is expressed as a percentage of the total length of the composite surface. Microradiographic examination for periods of up to 26 weeks after implantation revealed that APC50, APC70, and APC80 all exhibited excellent osteoconductivity and made direct contact with the bone with no interposed soft tissues. However, the higher the AL-P content of the composite, the higher the osteoconductivity, especially at 4 weeks after the operation. Moreover, the amount of bone directly apposed to the composite surface increased with time. In contrast, little bone formation was seen on the surface of SGC70, even after 26 weeks. Observation by scanning electron microscope-energy dispersive X-ray microanalysis demonstrated that bone made direct contact with the APC surface through a layer containing calcium, phosphorus, and alumina powder. These results suggest that APC shows promise as a basis for developing mechanically strong and highly osteoconductive composites.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Kawahara-cho 54, Shogoin, Sakyo-ku, Kyoto 606-8397, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Shinzato
authors.forename: K
authors.initials: K
authors.lastname: Kawanabe
authors.forename: M
authors.initials: M
authors.lastname: Neo
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
authors.forename: T
authors.initials: T
authors.lastname: Kikutani
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D017438:Bisphenol A-Glycidyl Methacrylate; D001843:Bone Cements; D018786:Bone Substitutes; D004577:Electron Probe Microanalysis; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D011208:Powders; D017438:Bisphenol A-Glycidyl Methacrylate; D000537:Aluminum Oxide