title: In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array.
abstract: A 256-element, continuous-wave ultrasonic phased array has been used to thermally coagulate deep-seated liver and kidney tissue. The array elements were formed on a 1-3 piezocomposite bowl with a 10-cm radius of curvature and 12-cm diameter. The 0.65 x 0.65 cm2 projection elements were driven at 1.1 MHz by a custom-built amplifier system. A series of in vivo porcine experiments demonstrated the ability to coagulate liver and kidney tissue using the large-scale phased array. The temperature response of the treatment was guided and monitored using magnetic resonance (MR) images. Focal lesion volumes greater than 0.5 cm3 in kidney and 2 cm3 in liver were formed from a single 20-s sonication.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Daum
authors.forename: N B
authors.initials: NB
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: King
authors.forename: K
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000818:Animals; D004867:Equipment Design; D005240:Feasibility Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D013552:Swine; D014464:Ultrasonic Therapy / Q000295:instrumentation*