title: [Epidemiologic data for tetanus prophylaxis. Assessment of the need for vaccination].
abstract: OBJECTIVE
  In spite of the low morbidity secondary to tetanus, the high fatality rate (about 50%) requires effective and extensive protection of the population by vaccination. Since documentation is often lacking, booster tetanus vaccination is frequently applied in cases of minor injury. This leads to vaccination associated complications such as hyperergic reactions. The more intense the vaccination-associated side effects are, the less revaccination is possible. We investigated the tetanus immune status of a selected Austrian population.
  
  
  METHODS
  Tetanus antitoxin antibodies were measured with ELISA (Immunozym Tetanus, Immuno AG) in serum samples from 218 subjects who were hospitalised in a dermatology unit. In addition, patient history and data concerning vaccination were collected.
  
  
  RESULTS
  Based on the assumption that an antitoxin level of 0.1 IU/ml provides sufficient protection, 63% of the subjects were found to be adequately protected. 56% showed high antibody concentrations above 0.5 IU/ml. However, the data also revealed no protection by vaccination in 37% of the subjects. Data obtained by case history or vaccination certificates could not serve as a discrimination factor for applying revaccination or not.
  
  
  CONCLUSIONS
  We strongly recommend better documentation of tetanus vaccination. In some cases, a search for tetanus antibodies before applying booster tetanus vaccination might be necessary.
authors.affiliation: Abteilung für Umweltdermatologie, Universitätsklinik für Dermatologie und Venerologie, Graz, Osterreich.
authors.forename: E
authors.initials: E
authors.lastname: Brabek
authors.forename: B
authors.initials: B
authors.lastname: Kränke
authors.forename: D
authors.initials: D
authors.lastname: Stünzner
authors.forename: W
authors.initials: W
authors.lastname: Aberer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000917:Antibody Formation / Q000276:immunology; D001317:Austria / Q000453:epidemiology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007109:Immunity; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D013742:Tetanus / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects*; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects
chemical_list: D013745:Tetanus Toxoid
vernacular_title: Epidemiologische Daten zum Tetanusschutz. Zwischen Impfnotwendigkeit und Uberimpfung.