Infection with parapoxvirus induces CD30-positive cutaneous infiltrates in humans.
Expression of CD30 is a distinct feature of B- or T-cell activation, found in Hodgkin's disease, large cell anaplastic lymphoma, lymphomatoid papulosis, as well as in certain viral infections such as human T-lymphotropic virus type I, HIV, hepatitis B and C virus, and Epstein-Barr virus. Here, we report highly proliferative CD30-positive cutaneous infiltrates in 3 patients with Milkers's nodules, adding parapoxvirus infection to the spectrum of CD30-positive benign lympho-proliferations.
Rose
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C
Department of Dermatology, University of Würzburg, Germany.
Starostik
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P
Bröcker
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EB
D000328:Adult; D000368:Aged; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis* / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D018157:Parapoxvirus / Q000472:pathogenicity* / Q000648:ultrastructure; D011213:Poxviridae Infections / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D012867:Skin / Q000473:pathology / Q000821:virology*; D017193:Skin Diseases, Viral / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
D017730:Ki-1 Antigen; D011948:Receptors, Antigen, T-Cell