Putative inflammatory and immunological mechanisms in functional bowel disorders.
The observations that irritable bowel syndrome (IBS) may be precipitated by an acute enteric infection, or occurs commonly in patients in remission from inflammatory bowel disease (IBD) has prompted consideration of inflammation as a putative basis for symptom generation in IBS. In this regard, IBS may follow a pattern of pathogenesis that is similar to asthma--which was once considered a psychosomatic disease. This review examines the basic scientific evidence of a functional interface between the immune and sensory-motor systems of the gut and discusses how this may be relevant to a subgroup of IBS patients. In addition, review will examine the implications of this for the diagnosis and treatment of IBS.
Collins
S M
SM
Intestinal Diseases Research Unit, McMaster University Medical Center, Hamilton, Ontario, Canada.
Vallance
B
B
Barbara
G
G
Borgaonkar
M
M
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D017615:Enteric Nervous System / Q000276:immunology / Q000378:metabolism; D005759:Gastroenteritis / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000209:etiology / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology / Q000294:innervation; D008214:Lymphocytes / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009479:Neuropeptides / Q000378:metabolism
D016207:Cytokines; D009479:Neuropeptides