Acyclic structural variants of growth hormone secretagogue L-692,429.
Systematic investigation of acyclic analogs of L-692,429, the prototype benzolactam growth hormone secretagogue, has helped to further define the structural requirements for the release of growth hormone from rat pituitary cells for this class of secretagogues.
Lin
P
P
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
Pisano
J M
JM
Schoen
W R
WR
Cheng
K
K
Chan
W W
WW
Butler
B S
BS
Smith
R G
RG
Fisher
M H
MH
Wyvratt
M J
MJ
D000818:Animals; D001552:Benzazepines / Q000737:chemistry* / Q000494:pharmacology; D002478:Cells, Cultured; D013006:Growth Hormone / Q000378:metabolism; D015394:Molecular Structure; D010902:Pituitary Gland / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D013777:Tetrazoles / Q000737:chemistry* / Q000494:pharmacology
D001552:Benzazepines; D013777:Tetrazoles; C081455:L 692429; D013006:Growth Hormone