title: Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly.
abstract: Pituitary apoplexy is the most serious and life-threatening complication of pituitary adenomas. Most of the cases occur spontaneously but it may occur also after a number of events such as the pituitary stimulation tests. We report a case of acromegaly due to a giant pituitary adenoma in which pituitary apoplexy developed 88 hours after TRH/GnRH stimulation test. The patient had severe headaches, nausea, vomiting, visual disturbance and mental alteration and the computed tomography (CT) scans revealed intratumoral and intraventricular bleeding. The pituitary mass was removed by transsphenoidal approach. The patient developed pneumonia and died on the 9th postoperative day. Pituitary apoplexy was confirmed at surgery and on histological examination. Immunohistochemical staining was positive for GH and PRL. This case indicates that pituitary apoplexy may develop several days after TRH/GnRH stimulation test.
authors.affiliation: Department of Endocrinology, Erciyes University, Medical School, Kayseri, Turkey.
authors.forename: H S
authors.initials: HS
authors.lastname: Dökmetaş
authors.forename: A
authors.initials: A
authors.lastname: Selçuklu
authors.forename: R
authors.initials: R
authors.lastname: Colak
authors.forename: K
authors.initials: K
authors.lastname: Unlühizarci
authors.forename: F
authors.initials: F
authors.lastname: Bayram
authors.forename: F
authors.initials: F
authors.lastname: Keleştimur
mesh_terms: D000172:Acromegaly / Q000175:diagnosis* / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000175:diagnosis; D000328:Adult; D017809:Fatal Outcome; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects*; D006801:Humans; D010899:Pituitary Apoplexy / Q000139:chemically induced* / Q000175:diagnosis* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000175:diagnosis; D013973:Thyrotropin-Releasing Hormone / Q000009:adverse effects*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone