title: Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases.
abstract: Angioedema is a rare but potentially fatal side effect of angiotensin converting enzyme (ACE) inhibitors. We report for the first time, two children with systemic lupus erythematosus who developed acute angioedema after the long-term use of enalapril. Prompt recognition and appropriate management of ACE-induced angioedema prevented life-threatening complications. This report highlights the potential risks of angioedema associated with the use of ACE inhibitors in children. Patients should be advised to seek medical treatment immediately if they experience swelling of the face, neck, or tongue, and especially if they have trouble breathing, speaking, or swallowing.
authors.affiliation: Department of Pediatrics, Division of Nephrology, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA. fassadi@nemours.org
authors.forename: F K
authors.initials: FK
authors.lastname: Assadi
authors.forename: H E
authors.initials: HE
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Lawless
authors.forename: C P
authors.initials: CP
authors.lastname: McKay
authors.forename: L
authors.initials: L
authors.lastname: Hopp
authors.forename: D
authors.initials: D
authors.lastname: Fattori
mesh_terms: D000293:Adolescent; D000799:Angioedema / Q000139:chemically induced* / Q000175:diagnosis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002648:Child; D004656:Enalapril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008297:Male
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril