title: Coronary flow velocity immediately after reperfusion reflects myocardial microcirculation in canine models of acute myocardial infarction.
abstract: Recent reports indicate that the coronary microcirculation is sometimes injured, despite successful reperfusion in acute myocardial infarction (AMI). However, it is difficult to evaluate the coronary microcirculation immediately after reperfusion by using only angiography. The purpose of this study was to examine the relationship between the pattern of coronary blood flow velocity and myocardial microcirculatory injury immediately after reperfusion in AMI. The authors recorded the left circumflex coronary flow velocity by using the Doppler guide wire method 10 minutes after reperfusion in a canine model of AMI. In addition, myocardial contrast echocardiography was performed with the injection of contrast medium into the left circumflex coronary artery before clamping of the coronary artery and 15 minutes after release of the clamp. From these images, the ratio of the normalized gray-level postreperfusion to preclamping in the contrast-enhanced area was determined. It was compared with coronary flow velocity variables. In the 10 dogs with a diastolic-to-systolic velocity ratio (DSVR) < 4.0, this velocity ratio 10 minutes after reperfusion correlated positively (r = 0.75, p < 0.01) with the normalized gray-level ratio. However, the remaining three dogs with a DSVR > or = 4.0 markedly deviated from this pattern. Coronary flow velocities in the three dogs were characterized by a greater decrease in systolic flow velocity and occurrence of early systolic retrograde flow. Myocardial contrast echocardiographic images in these three dogs demonstrated a lower normalized gray-level ratio. In conclusion, the coronary flow velocity pattern immediately after reperfusion may reflect myocardial microcirculatory injury.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, The University of Tokushima, Japan. wakatuki@clin.med.tokushima-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Wakatsuki
authors.forename: T
authors.initials: T
authors.lastname: Oki
authors.forename: K
authors.initials: K
authors.lastname: Sakabe
authors.forename: H
authors.initials: H
authors.lastname: Shinohara
authors.forename: J
authors.initials: J
authors.lastname: Ikata
authors.forename: T
authors.initials: T
authors.lastname: Tabata
authors.forename: A
authors.initials: A
authors.lastname: Nishikado
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000418:Albumins; D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D004285:Dogs; D004452:Echocardiography; D015150:Echocardiography, Doppler; D008833:Microcirculation / Q000503:physiopathology; D008863:Microspheres; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D000418:Albumins; C060687:Albunex; D003287:Contrast Media