Potassium supplementation increases sodium excretion and nitric oxide production in hypertensive Dahl rats.
The present study was designed to investigate whether antihypertensive and natriuretic effects of K were achieved by elevation of nitric oxide (NO) production in Dahl salt-sensitive (DS) rats. The rats were placed in individual metabolic cage and fed a high sodium diet with or without K supplementation for 4 weeks. K supplementation counteracted the blood-pressure raising effect of NaCl. K supplementation significantly enhanced sodium excretion and reduced sodium retention, increased the urinary nitrite plus nitrate excretion and kidney constitutive NO synthase activity in salt-loaded DS rats. These effect did not occur in the rats fed a low sodium diet with K supplementation. These results suggest that K supplementation attenuates development of hypertension with reduction of sodium retention in salt-loaded DS rats, which is mediated by the recovery of salt-induced NO production mechanism.
Zhou
M S
MS
2nd Department of Physiology, Kagawa Medical University, Japan.
Nishida
Y
Y
Yoneyama
H
H
Chen
Q H
QH
Kosaka
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009566:Nitrates / Q000652:urine; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009573:Nitrites / Q000652:urine; D009929:Organ Size; D011188:Potassium / Q000097:blood / Q000652:urine; D017419:Potassium, Dietary / Q000008:administration & dosage*; D051381:Rats; D020303:Rats, Inbred Dahl; D012964:Sodium / Q000097:blood / Q000652:urine*; D012982:Sodium, Dietary / Q000008:administration & dosage; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance
D009566:Nitrates; D009573:Nitrites; D017419:Potassium, Dietary; D012982:Sodium, Dietary; D009569:Nitric Oxide; D012964:Sodium; D019001:Nitric Oxide Synthase; D011188:Potassium; D002118:Calcium