[The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms].
The susceptibility of the ICR, DD/He and CC57/BR mice to urethane-induced lung tumors was analyzed in comparison with the A/He (highly susceptible) and AKR (resistant) lines of mice. Allelic variants of the K-Ras gene intron 2 in these lines have been determined. Susceptibility of the ICR mice was similar to that of the A mice, and intron 2 of the K-Ras ICR gene carried the 37-bp deletion analogous to that described in the A/He line. The DD mice intron 2 also contained the deletion, but despite the presence of the "susceptible" K-Ras allele, the DD/He mice were resistant to urethane induction of lung tumors. The CC57BR line carried the deletion and demonstrated relatively high susceptibility. Our findings indicate that the K-Ras gene may be important in the chemical induction of lung tumors.
Timofeeva
O A
OA
Novosibirsk Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia.
Filipenko
M L
ML
Kaledin
V I
VI
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D011905:Genes, ras; D020022:Genetic Predisposition to Disease; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000235:genetics*; D051379:Mice; D008813:Mice, Inbred ICR; D014520:Urethane / Q000633:toxicity*
D002273:Carcinogens; D014520:Urethane
Izuchenie korreliatsii mezhdu genotipom gena K-ras i chuvstvitel'nost'iu mysheĭ k khimicheskoĭ induktsii opukholeĭ legkogo.