Consumption of a buckwheat protein extract retards 7,12-dimethylbenz[alpha]anthracene-induced mammary carcinogenesis in rats.
Female rats were examined for the effects of feeding buckwheat protein extract (BWPE) on the development of mammary tumor caused by administration of 7,12-dimethylbenz[alpha]anthracene. The percentage of rats with palpable mammary tumors and serum estradiol were lower in the BWPE-fed animals than the casein-fed ones, implying that BWPE intake retarded the mammary carcinogenesis by lowering serum estradiol.
Kayashita
J
J
Development, Health Care, Kissei Pharmaceutical Company, Matsumoto, Japan.
Shimaoka
I
I
Nakajoh
M
M
Kishida
N
N
Kato
N
N
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D002364:Caseins / Q000008:administration & dosage; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D004958:Estradiol / Q000097:blood; D019612:Fagopyrum / Q000737:chemistry*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D010940:Plant Proteins / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D016588:Anticarcinogenic Agents; D002364:Caseins; D004044:Dietary Proteins; D010940:Plant Proteins; D004958:Estradiol; D015127:9,10-Dimethyl-1,2-benzanthracene