title: On the statistical nature of mammograms.
abstract: We show that digitized mammograms can be considered as evolving from a simple process. A given image results from passing a random input field through a linear filtering operation, where the filter transfer function has a self-similar characteristic. By estimating the functional form of the filter and solving the corresponding filtering equation, the analysis shows that the input field gray value distribution and spectral content can be approximated with parametric methods. The work gives a simple explanation for the variegated image appearance and multimodal character of the gray value distribution common to mammograms. Using the image analysis as a guide, a simulated mammogram is generated that has many statistical characteristics of real mammograms. Additional benefits may follow from understanding the functional form of the filter in conjunction with the input field characteristics that include the approximate parametric description of mammograms, showing the distinction between homogeneously dense and nondense images, and the development of mass analysis methods.
authors.affiliation: Department of Radiology, College of Medicine, The University of South Florida, and the H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-4799, USA. heine@splinter.rad.usf.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Heine
authors.forename: S R
authors.initials: SR
authors.lastname: Deans
authors.forename: R P
authors.initials: RP
authors.lastname: Velthuizen
authors.forename: L P
authors.initials: LP
authors.lastname: Clarke
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D005260:Female; D017709:Fractals; D006801:Humans; D008327:Mammography / Q000379:methods*; D015233:Models, Statistical; D016011:Normal Distribution; D011856:Radiographic Image Enhancement / Q000379:methods*