[Value of fetal lung maturity assessment in maternal diabetes].
OBJECTIVE
Results of antepartal fetal lung maturity (FLM) testing in diabetics were compared to control patients. We analysed 274 patients by phospholipid profile and 219 by phosphatidylglycerol (PG), consisting of 73, respectively 54 diabetic and 201, resp. 165 normal control subjects.


METHODS
Phospholipid concentration increased exponentially with gestational age (rreg = 0.44 for diabetic and 0.57 for normal control patients). There was no significant difference between both groups. Measurement of PG showed a trend towards lung immaturity in diabetic infants for preterm and term gestations, which did not reach significance (chi-square [chi 2] test 0.07, resp. 0.06).


RESULTS
Diabetic and non-diabetic pregnancies did not differ significantly in FLM and RDS frequency. Both methods show a high rate of falsely immature results. Antepartal FLM testing by measurement of phospholipids and PG does not play a role in clinical management of diabetic patients.
Beinlich
A
A
Frauenklinik, J. W. Goethe Universität, Frankfurt am Main.
Fischäss
C
C
Kaufmann
M
M
Schlösser
R
R
Dericks-Tan
J S
JS
D000649:Amniocentesis; D005189:False Positive Reactions; D005260:Female; D005325:Fetal Organ Maturity / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D008297:Male; D010715:Phosphatidylglycerols / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000175:diagnosis* / Q000503:physiopathology; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors; D012680:Sensitivity and Specificity
D010715:Phosphatidylglycerols; D010743:Phospholipids
Wert der fetalen Lungenreifebestimmung bei mütterlichem Diabetes.