The cell cycle and development: redundant roles of cell cycle regulators.
The existence of families of cell cycle regulators reflects the need by a developing organism to precisely control proliferation of its cells and also suggests that family members may play redundant roles. Recent advances have shown redundancy to be a theme in development.
Zhang
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Division of Basic Sciences, Department of Pharmacology, National Jewish Medical and Research Center, University of Colorado Medical School, Denver, CO 80206, USA. zhangp@njc.org.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002454:Cell Differentiation; D019938:Cyclin D1 / Q000502:physiology; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D011518:Proto-Oncogene Proteins; D016160:Retinoblastoma Protein / Q000502:physiology
D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D016160:Retinoblastoma Protein; D019938:Cyclin D1; C495902:Cdk4 protein, mouse; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases