Quantitative trait locus detection using combined linkage/disequilibrium analysis.
We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by-state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification.
Almasy
L
L
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA.
Williams
J T
JT
Dyer
T D
TD
Blangero
J
J
D000437:Alcoholism / Q000235:genetics; D000483:Alleles; D018913:Event-Related Potentials, P300 / Q000235:genetics; D005820:Genetic Testing / Q000379:methods*; D016678:Genome; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D019655:Quantitative Trait, Heritable