Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days.
The pharmacokinetics of florfenicol, a structural analogue of thiamphenicol, were studied in six pigs after single oral and intramuscular doses of 15 mg/kg bodyweight, and after feeding them with medicated feed containing 250 mg/kg for three days, a concentration which provided approximately the same dose rate of the drug. The oral doses contained a specially prepared pelleted formulation of the drug. The bioavailability of the drug was similar for the oral and intramuscular doses. Florfenicol was absorbed rapidly from the feed and its concentration in plasma remained between 2 and 6 microg/ml - above the minimum inhibitory concentration values for common pig pathogens - during the three days.
Voorspoels
J
J
Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Gent, Belgium.
D'Haese
E
E
De Craene
B A
BA
Vervaet
C
C
De Riemaecker
D
D
Deprez
P
P
Nelis
H
H
Remon
J P
JP
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D006207:Half-Life; D007273:Injections, Intramuscular; D007408:Intestinal Absorption; D013552:Swine / Q000097:blood*; D013839:Thiamphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; C035534:florfenicol; D013839:Thiamphenicol