Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia.
The penetration of trovafloxacin (TVA), 200 mg once daily, into the airways of 17 patients with severe pneumonia was studied. The mean (standard deviations are given in parentheses) steady-state TVA concentrations, 2 h after the last intake, were 3.1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1.1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoalveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11).
Peleman
R A
RA
Division of Infectious Diseases, Department of Internal Medicine, University Hospital Ghent, 185 De Pintelaan, B9000 Ghent, Belgium. renaat.peleman@rug.ac.be
Van De Velde
V
V
Germonpré
P R
PR
Fleurinck
C
C
Rosseel
M T
MT
Pauwels
R A
RA
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy*; D013183:Sputum / Q000378:metabolism*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin