Synaptic neurone activity under applied 50 Hz alternating magnetic fields.
The effect of 50 Hz alternating magnetic fields of 10-150 Gauss (1-15 mT) intensity on neurone synaptic activity for glutamate and acetylcholine has been studied. The applied 50 Hz alternating magnetic field does not modify the synaptic activity induced by glutamate or acetylcholine on neurones. It has been observed that both caffeine and glutamate induce similar effects, either stimulation or inhibition, on different neurone types. It is shown that applied 50 Hz alternating magnetic fields mimic the synaptic effect of glutamate. A mimic effect has also been observed between the induced effect by applying 50 Hz alternating magnetic field on neurones and the one induced by caffeine and glutamate on the same neurone. The application of Ringer solutions with different concentrations of Ca2+/K+ ions suggest that Ca2+ ions are involved in the elicited responses to either caffeine, glutamate or 50 Hz magnetic fields. Our conclusion is that the observed mimic induced effects for 50 Hz alternating magnetic fields, caffeine and glutamate on neurones corroborate that Ca2+ ions are the cytosolic effectors of the applied 50 Hz alternating magnetic fields interaction with neurone plasma membrane.
Calvo
A C
AC
Instituto de Bioelectromagnetismo, Alonso de Santa Cruz, Facultad de Medicina, Universidad de Zaragoza, Spain.
Azanza
M J
MJ
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D004574:Electromagnetic Fields; D018698:Glutamic Acid / Q000494:pharmacology; D006372:Helix, Snails; D007395:Interneurons / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D002110:Caffeine; D018698:Glutamic Acid; D000109:Acetylcholine; D002118:Calcium