title: Advanced Hodgkin's disease in a pregnant HIV seropositive woman: favorable mother and baby outcome following combined anticancer and antiretroviral therapy.
abstract: We describe a 33 y/o HIV(+) woman who developed advanced Hodgkin's disease (HD) during the 2nd trimester of her pregnancy. Combination chemotherapy and antiretroviral treatment along with opportunistic infection prophylaxis were administered. At term, while in partial remission, she delivered by a Caesarian section a healthy baby, PCR-negative for HIV. A complete remission was later achieved upon completion of the chemotherapy regimen. Since both the incidence of HD and the proportion of young women among the HIV(+) individuals are increasing, it seems important to recognize that successful completion of pregnancy with no deterioration of accepted surrogate parameters of HIV disease progression is achievable in a carefully treated HIV(+) pregnant woman with advanced HD.
authors.affiliation: Hematology Institute, Kaplan Medical Center, Jerusalem, Rehovot, Israel. ak_md@netvision.net.il
authors.forename: A
authors.initials: A
authors.lastname: Klepfish
authors.forename: A
authors.initials: A
authors.lastname: Schattner
authors.forename: M
authors.initials: M
authors.lastname: Shtalrid
authors.forename: L
authors.initials: L
authors.lastname: Shvidel
authors.forename: A
authors.initials: A
authors.lastname: Berrebi
authors.forename: Z
authors.initials: Z
authors.lastname: Bentwich
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D012074:Remission Induction; D018119:Stavudine / Q000627:therapeutic use; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine; D018119:Stavudine