Cloning of the murine Mist1 gene and assignment to mouse chromosome band 5G2-5G3.
Mist1 is a basic helix-loop-helix (bHLH) transcription factor that is highly expressed in the adult pancreas. In this study, we isolated the mouse Mist1 gene and established its primary DNA sequence and complete genomic structure. Fluorescence in situ hybridization mapping located the Mist1 gene to the telomere of mouse chromosome 5 at position 5G2-5G3, an area which is syntenic to human chromosome 13q and which contains several additional pancreatic regulatory genes including IPF1 and CDX2.
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Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Lemercier
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Konieczny
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D003001:Cloning, Molecular; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D010179:Pancreas / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D014157:Transcription Factors; C491312:Bhlha15 protein, mouse