[Factors determining the therapeutic window in acute ischemic stroke: characteristics of PET studies].
OBJECTIVE
To make a brief review of the use of PET in the study of patients with acute ischemic stroke.


METHODS
In the cerebral cortex PET may be used to detect a series of changes which permit the definition of three types of patients with different prognoses. The patients of type 1 (severe fall in cerebral blood flow and CMRO2) have an unfavorable prognosis and do not benefit from fibrinolytic treatment and/or neuroprotection to assist recovery of areas of penumbra. Patients of type 2 (marked drop in cerebral blood flow with moderate reduction of CMRO2) have a doubtful prognosis and are those which, in theory, might benefit from fibronolytic and/or neuroprotector treatment to help recovery of zones of penumbra. The patients of type 3 (focal hyperperfusion with CMRO2 maintained) have a favorable spontaneous prognosis.


CONCLUSIONS
This technique also shows that the therapeutic window should be individually analyzed in each case. This data is of great interest when planning therapeutic clinical studies.
Baron
J C
JC
Servicio de Neurología, CHU Caen, Francia.
D000208:Acute Disease; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000378:metabolism; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D011379:Prognosis; D014055:Tomography, Emission-Computed
D010100:Oxygen
Factores determinantes de la ventana terapéutica en el ictus isquémico agudo: características de los estudios de tomografía por emisión de positrones.