The antiinflammatory activity of Icacina trichantha tuber.
Five fractions (hexane, chloroform, ethylacetate, methanol and water) of Icacina trichantha tuber were obtained by gradient solvent extraction and tested for their ability to inhibit the Croton oil-induced ear edema in mice. The most active fraction was the chloroform one which significantly inhibited ear edema in a dose-dependent manner, showing an ID50 (dose giving 50% edema inhibition) of 107 micrograms/cm2. The ID50 of the reference drug indomethacin was 93 micrograms/cm2. The chloroform fraction significantly reduced also the carrageenin-induced paw edema in rats, after oral adiminstration: 50, 100 or 200 mg/kg of the fraction reduced the global edematous response by 15, 20 or 34%, whereas 10 mg/kg of indomethacin induced 40% inhibition.
Asuzu
I U
IU
Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka.
Sosa
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Della Loggia
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D002851:Chromatography, High Pressure Liquid; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004423:Ear; D004487:Edema / Q000517:prevention & control*; D005528:Foot; D007249:Inflammation; D007509:Irritants; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D007509:Irritants; D010936:Plant Extracts; D003436:Croton Oil; D002351:Carrageenan