title: Combined treatment of metastatic osteosarcoma of the spine.
abstract: We report on a 28-year-old male with a single metastasis of an osteosarcoma in the twelfth thoracic vertebra occurring 9 years after initial diagnosis of the primary tumour in the left distal femur and neoadjuvant treatment according to a modified T-10 protocol. After pre-operative second-line combination chemotherapy with doxorubicin, carboplatin and etoposide leading to regression of the primarily inoperable metastasis wide resection of the tumour employing total spondylectomy was done. The duration of response had been 65 months since the end of subsequent postoperative chemotherapy with the same regimen.
authors.affiliation: Department of Internal Medicine and Division of Oncology, Karl Franzens University Graz, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Bauernhofer
authors.forename: H
authors.initials: H
authors.lastname: Stöger
authors.forename: A K
authors.initials: AK
authors.lastname: Kasparek
authors.forename: F
authors.initials: F
authors.lastname: Ploner
authors.forename: I
authors.initials: I
authors.lastname: Kuss
authors.forename: T R
authors.initials: TR
authors.lastname: Pieber
authors.forename: R
authors.initials: R
authors.lastname: Kotz
authors.forename: H
authors.initials: H
authors.lastname: Samonigg
mesh_terms: D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005266:Femoral Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D004317:Doxorubicin; D016190:Carboplatin