Incidence of factor V Leiden in patients with acute myocardial infarction.
The genetic defect of coagulation factor V known as factor V Leiden produces a resistance to degradation by activated protein C (APC) and increases the risk of venous thromboembolism. The data on arterial thrombosis associated with APC resistance are still not clearly defined. We conducted a study in patients presenting with acute myocardial infarction (MI) to assess whether factor V Leiden increases the risk of arterial thrombosis. We studied 109 patients who had a diagnosis of acute MI (69 males and 40 females, aged 25-91 years), and 112 controls. The study population was identified by characteristic ECG changes and elevation of serum CK-MB, whereas the control subjects were anonymous healthy blood donors with no known history of coronary artery disease. Blood samples from the patients and controls were analyzed for the factor V Leiden mutation by DNA analysis, using the polymerase chain reaction. Heterozygous factor V Leiden mutation was found in 9 of 109 (8%) MI patients and 5 of 112 (4%) control subjects (P =.42). In conclusion, this study shows no evidence of an association between factor V Leiden and acute MI.
Gowda
M S
MS
University of MissouriKansas City, Mid America Heart Institute and Department of Pathology, St. Lukes Hospital, Kansas City, Missouri, USA.
Zucker
M L
ML
Vacek
J L
JL
Carriger
W L
WL
Van Laeys
D L
DL
Rachel
J M
JM
Strope
B D
BD
D020016:Activated Protein C Resistance; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology / Q000235:genetics*; D017354:Point Mutation; D016133:Polymerase Chain Reaction
C095381:factor V Leiden; D005165:Factor V