Prooxidant action of aluminum ion--stimulation of iron-mediated lipid peroxidation by aluminum.
Prooxidant nature of aluminum ion was analyzed in relation to iron coordination. Aluminum ion effectively enhanced the formation of thiobarbituric acid-reactive substances as a marker of lipid peroxidation of microsomes from rat liver under the acidic conditions, and this metal further attenuated the antioxidant action of flavonoids such as quercetin and baicalein under neutral conditions. Autooxidation of ferrous ion was markedly inhibited by aluminum ion. Aluminum can act as a prooxidant by stabilizing reduced iron the initiating species for lipid peroxidation, and by inhibiting the antioxidant action of flavonoid.
Yoshino
M
M
Department of Biochemistry, Aichi Medical University, Japan. yoshino@aichi-med-u.ac.jp
Ito
M
M
Haneda
M
M
Tsubouchi
R
R
Murakami
K
K
D000535:Aluminum / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology
D005419:Flavonoids; D017382:Reactive Oxygen Species; D000535:Aluminum; D007501:Iron; D015032:Zinc