Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397).
Kawamoto
H
H
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Banyu Pharmaceutical Company Ltd., Okubo 3, Tsukuba, Ibaraki 300-2611, Japan.
Ozaki
S
S
Itoh
Y
Y
Miyaji
M
M
Arai
S
S
Nakashima
H
H
Kato
T
T
Ohta
H
H
Iwasawa
Y
Y
D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000819:agonists*; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; C402921:J 113397; D010880:Piperidines; D011957:Receptors, Opioid