Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: summary of GAW11 contributions.
We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
Almasy
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Department of Genetics (L.A.), Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA.
Borecki
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D000437:Alcoholism / Q000209:etiology / Q000235:genetics*; D004493:Education; D005192:Family Health; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D012307:Risk Factors; D012984:Software