title: In-111 octreotide scan in a case of a neuroendocrine tumor of unknown origin.
abstract: Major neuroendocrine tumors contain many somatostatin receptors. This feature allows for the localization of primary tumors and tumor metastases by scintigraphy with the radiolabeled somatostatin analog octreotide. We describe a patient with nonspecific clinical data and ultrasonography and CT that showed an isolated focal lesion in the liver. In-111 octreotide scintigraphy was essential in establishing the diagnosis of liver metastasis from a neuroendocrine tumor confirmed by pathologic findings. Because clinical symptoms recurred, ultrasonography and CT were performed a few months after surgery. Both were negative. However, In-111 octreotide scintigraphy suggested multiple bone metastases and established the diagnosis of bone metastases from a neuroendocrine tumor, which was confirmed by Tc-99m MDP bone scans and MRI.
authors.affiliation: Department of Nuclear Medicine, Hospital Clínic i Provincial, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Fuster
authors.forename: M
authors.initials: M
authors.lastname: Navasa
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.forename: S
authors.initials: S
authors.lastname: Vidal-Sicart
authors.forename: J J
authors.initials: JJ
authors.lastname: Mateos
authors.forename: F
authors.initials: F
authors.lastname: Lomeña
authors.forename: J
authors.initials: J
authors.lastname: Rodes
authors.forename: R
authors.initials: R
authors.lastname: Herranz
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging / Q000556:secondary*; D005500:Follow-Up Studies; D006801:Humans; D007205:Indium Radioisotopes; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000000981:diagnostic imaging*; D015282:Octreotide / Q000031:analogs & derivatives*; D010384:Pelvic Bones / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000187:drug effects; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D015282:Octreotide; D013669:Technetium Tc 99m Medronate