title: Alternative medicine use in patients with localized prostate carcinoma treated with curative intent.
abstract: BACKGROUND
  Alternative medicine therapies are estimated to be used by 7-64% of cancer patients but up to 72% do not inform their physician. To the authors' knowledge little useful information is available regarding the prevalence of alternative medicine use by patients with prostate carcinoma. Thus, the authors attempted to evaluate the prevalence of alternative medicine use by prostate carcinoma patients treated with curative intent by either radical prostatectomy, brachytherapy alone, or a combination of brachytherapy and external radiation therapy.
  
  
  METHODS
  Between January 1997 and May 1998, 234 men with clinically localized prostate carcinoma underwent radical prostatectomy (54 patients) or brachytherapy (180 patients) with (74 patients) or without (106 patients) external beam radiation therapy. In July 1998 a questionnaire was mailed to all patients comprised of multiple questions regarding alternative medicine use to which 190 patients (81%) responded. The overall prevalence and types of alternative medicine therapies used were assessed and the relation between age at procedure, pretreatment prostate specific antigen level, clinical stage, pretreatment Gleason score, and type of treatment with the use of alternative medicine therapies was evaluated using univariate and multivariate analysis.
  
  
  RESULTS
  The prevalence of alternative medicine use by prostate carcinoma patients responding to the survey was 43% (81 of 190 patients). No significant differences in alternative medicine use were observed between the patients who received brachytherapy alone (38%), those who underwent radical prostatectomy (40%), and those treated with combined brachytherapy and external beam radiation therapy (51%). Vitamins, prayer or other religious practices, and herbal medicines were the most commonly used therapies in these patients. Higher pretreatment Gleason scores were associated with a greater use of alternative medicine therapies on both multivariate and univariate analyses. Finally, using multivariate analysis, younger prostate carcinoma patients were more likely to use alternative medicine therapies than older patients.
  
  
  CONCLUSIONS
  Alternative medicine use is very prevalent among patients treated for localized prostate carcinoma. Because some of these treatments may have a potential biologic impact on tumor behavior and, consequently, on definitive or surrogate therapeutic endpoints, patients should be questioned carefully regarding alternative medicine use during routine tumor follow-up.
authors.affiliation: Department of Urology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Lippert
authors.forename: R
authors.initials: R
authors.lastname: McClain
authors.forename: J C
authors.initials: JC
authors.lastname: Boyd
authors.forename: D
authors.initials: D
authors.lastname: Theodorescu
mesh_terms: D000368:Aged; D001918:Brachytherapy; D003131:Combined Modality Therapy; D000529:Complementary Therapies / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000628:therapy*; D011795:Surveys and Questionnaires; D014481:United States