title: The antiinflammatory activity of Icacina trichantha tuber.
abstract: Five fractions (hexane, chloroform, ethylacetate, methanol and water) of Icacina trichantha tuber were obtained by gradient solvent extraction and tested for their ability to inhibit the Croton oil-induced ear edema in mice. The most active fraction was the chloroform one which significantly inhibited ear edema in a dose-dependent manner, showing an ID50 (dose giving 50% edema inhibition) of 107 micrograms/cm2. The ID50 of the reference drug indomethacin was 93 micrograms/cm2. The chloroform fraction significantly reduced also the carrageenin-induced paw edema in rats, after oral adiminstration: 50, 100 or 200 mg/kg of the fraction reduced the global edematous response by 15, 20 or 34%, whereas 10 mg/kg of indomethacin induced 40% inhibition.
authors.affiliation: Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka.
authors.forename: I U
authors.initials: IU
authors.lastname: Asuzu
authors.forename: S
authors.initials: S
authors.lastname: Sosa
authors.forename: R
authors.initials: R
authors.lastname: Della Loggia
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan; D002851:Chromatography, High Pressure Liquid; D003436:Croton Oil; D004305:Dose-Response Relationship, Drug; D004423:Ear; D004487:Edema / Q000517:prevention & control*; D005528:Foot; D007249:Inflammation; D007509:Irritants; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D007509:Irritants; D010936:Plant Extracts; D003436:Croton Oil; D002351:Carrageenan