Haemorrhagic cystitis associated with adenovirus in a patient with AIDS treated for a non-Hodgkin's lymphoma.
Adenovirus-induced haemorrhagic cystitis has been reported chiefly in bone marrow or kidney transplant recipients. We report here on an HIV-positive patient treated for a Burkitt's lymphoma who developed gross haematuria associated with fever and burning urination. Usual causes of haematuria were ruled out: lithiasis, urinary tract lesions, glomerulonephritis, mycobacterium and schistosoma infections, and drug toxicity. Adenovirus was detected by cellular cultures and BK/JC virus DNA sequences were detected using a polymerase chain reaction method. Because BK/JC virus shedding is very common (75%) in HIV patients receiving chemotherapy, our data strongly suggest that adenovirus was responsible for the haemorrhagic cystitis in our patient. In conclusion, adenovirus should be considered as a potential cause of haemorrhagic cystitis in AIDS patients whose immunosuppression is aggravated by cytotoxic drugs.
Ghez
D
D
Service d'Immuno-Hématologie, Hôpital Saint-Louis, Paris, France.
Oksenhendler
E
E
Scieux
C
C
Lassoued
K
K
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000257:Adenoviridae Infections / Q000150:complications*; D000328:Adult; D001739:BK Virus / Q000302:isolation & purification; D002051:Burkitt Lymphoma / Q000150:complications*; D003556:Cystitis / Q000150:complications / Q000821:virology*; D006417:Hematuria; D006801:Humans; D007577:JC Virus / Q000302:isolation & purification; D016483:Lymphoma, AIDS-Related / Q000150:complications*; D008297:Male