title: Dynamic contrast-enhanced MRI of Implanted VX2 tumors in rabbit muscle: comparison of Gd-DTPA and NMS60.
abstract: We studied the dynamics of injected contrast enhancement in implanted VX2 tumors in rabbit thigh muscle. We compared two contrast agents Gd-DTPA and NMS60, a novel gadolinium containing trimer of molecular weight 2.1 kd. T1-weighted spin echo images were acquired preinjection and at 5-60 min after i.v. injection of 0.1 mmol/kg of agent. Dynamic T1-weighted SPGR images (1.9 s/image) were acquired during the bolus injection. Male NZW rabbits (n = 13) were implanted with approximately 2 x 10(6) VX2 tumor cells and grew tumors of 28+/-27 mL over 12 to 21 days. NMS60 showed significantly greater peak enhancement in muscle, tumor rim, and core compared to DTPA in both T1-weighted and SPGR images. NMS60 also showed delayed peak enhancement in the dynamic scans (compared to Gd-DTPA) and significantly reduced leakage rate constant into the extravascular space for tumor rim (K21 = 5.1 min(-1) vs. 11.5 min(-1) based on a 2 compartment kinetic model). The intermediate weight contrast agent NMS60 offers greater tumor enhancement than Gd-DTPA and may offer improved regional differentiation on the basis of vascular permeability in tumors.
authors.affiliation: Lucas Center, Dept. Radiology, Stanford University, CA 94305-5488, USA. alex@s-word.stanford.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: de Crespigny
authors.forename: D
authors.initials: D
authors.lastname: Howard
authors.forename: H
authors.initials: H
authors.lastname: D'Arceuil
authors.forename: H
authors.initials: H
authors.lastname: Muller
authors.forename: A T
authors.initials: AT
authors.lastname: Agoston
authors.forename: S
authors.initials: S
authors.lastname: Seri
authors.forename: Y
authors.initials: Y
authors.lastname: Hashiguchi
authors.forename: C
authors.initials: C
authors.lastname: Fujimoto
authors.forename: A
authors.initials: A
authors.lastname: Nakatani
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D002277:Carcinoma / Q000175:diagnosis*; D003287:Contrast Media / Q000737:chemistry; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019042:Muscle Neoplasms / Q000175:diagnosis*; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000737:chemistry; D011817:Rabbits; D013997:Time Factors
chemical_list: D003287:Contrast Media; C403805:NMS60; D009942:Organometallic Compounds; D019786:Gadolinium DTPA