title: Segregated expression of neurestin in the developing olfactory bulb.
abstract: Neurestin is a putative transmembrane protein whose expression is developmentally regulated in neurons. Here we examined neurestin expression pattern in mitral/tufted cells in the developing rat olfactory bulb. In the main olfactory bulb, neurestin expression was segregated in the dorso-rostral area and in the ventro-caudal area, but not in between. In the accessory olfactory bulb, neurestin expression was found only in the far caudal area. This area did not completely correspond to a caudal half of the vomeronasal nerve and glomerular layers positive for a G-protein Go alpha. These spatio-temporal expression patterns suggest that neurestin functions as a target recognition molecule that specifies zonal projection patterns of olfactory and vomeronasal sensory neurons.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Otaki
authors.forename: S
authors.initials: S
authors.lastname: Firestein
mesh_terms: D000818:Animals; D001931:Brain Mapping; D005314:Embryonic and Fetal Development / Q000502:physiology; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009830:Olfactory Bulb / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C120675:neurestin