title: The outcome of asthma related to workplace irritant exposures: a comparison of irritant-induced asthma and irritant aggravation of asthma.
abstract: OBJECTIVE
  (1) To characterize workers' compensation claims accepted on the basis of new-onset asthma associated with accidental high respiratory irritant exposure at work; (2) to compare the frequency, characteristics, and outcomes in this group of workers to workers who were compensated for an exacerbation of preexisting asthma associated with accidental high respiratory irritant exposure at work.
  
  
  METHODS
  A retrospective review was performed of 469 asthma claims accepted by the Ontario Workers' Compensation Board (WCB) between 1984 and 1988. Among these, claims attributed to an accidental high respiratory irritant exposure at work were classified into two groups: one group with reported preexisting asthma prior to the exposure (accidental aggravation of asthma [AAA]) and another group with no previous history of asthma (irritant-induced asthma [IIA]).
  
  
  RESULTS
  Of the 469 claims, 89 subjects (19%) had symptoms related to accidental high respiratory irritant exposure in the workplace; of these, 68 subjects (76%) had AAA, 12 subjects (13%) had IIA, and 9 subjects (10%) had possible IIA but were excluded from the analysis because of insufficient data. Those with IIA had a longer duration of work-attributed symptoms (mean, 219 +/- 208 days) than the subjects with AAA (mean, 32 +/- 38 days; p < 0.001). Nine subjects (75%) with IIA were no longer in the same work environment, while 47 subjects in the AAA group (71%) were still in the same work environment (p < 0.001). The most common triggering agent for subjects with IIA was an isocyanate spill; for those with AAA, the most common triggering agent was paint.
  
  
  CONCLUSIONS
  The WCB-accepted claims related to accidental, high respiratory irritant exposure at work are more commonly assigned to the category of AAA than to IIA. IIA patients in this claimant group had a longer mean duration of work-attributed respiratory symptoms, perhaps due to a need for a larger (and thus less common) irritant exposure to induce asthma in previously normal subjects.
authors.affiliation: School of Medicine, Catholic University of Rio Grande do Sul (PUCRS) Porto Alegre, R. S., Brazil.
authors.forename: J M
authors.initials: JM
authors.lastname: Chatkin
authors.forename: S M
authors.initials: SM
authors.lastname: Tarlo
authors.forename: G
authors.initials: G
authors.lastname: Liss
authors.forename: D
authors.initials: D
authors.lastname: Banks
authors.forename: I
authors.initials: I
authors.lastname: Broder
mesh_terms: D000328:Adult; D001249:Asthma / Q000145:classification / Q000191:economics* / Q000209:etiology*; D005260:Female; D006801:Humans; D007509:Irritants; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000191:economics*; D009864:Ontario; D012189:Retrospective Studies; D014942:Workers' Compensation; D017132:Workplace
chemical_list: D007509:Irritants