Docetaxel neuropathy: a distal axonopathy.
Docetaxel has been implicated as a causative agent in peripheral neuropathy, but pathological changes in peripheral nerve have not been described. During docetaxel treatment a 54-year-old man developed a sensorimotor polyneuropathy when the overall docetaxel dosage was 540 mg/m(2). Neurophysiological investigation revealed a sensorimotor axonal neuropathy. Fascicular sural nerve biopsy showed an axonal neuropathy with a preferentially loss of large myelinated fibers. There was evidence of considerable fiber regeneration. Sensory and motor symptoms progressively improved after docetaxel withdrawal.
Fazio
R
R
Department of Neurology, San Raffaele Scientific Institute, Via Olgettina 60, I-20132 Milan, Italy.
Quattrini
A
A
Bolognesi
A
A
Bordogna
G
G
Villa
E
E
Previtali
S
S
Canal
N
N
Nemni
R
R
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001369:Axons / Q000473:pathology*; D000077143:Docetaxel; D006801:Humans; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D017239:Paclitaxel / Q000009:adverse effects / Q000031:analogs & derivatives*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology; D043823:Taxoids
D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel