title: [Universal influenza vaccine still far in the future].
abstract: Recent publications suggest that a universal vaccine against human influenza might be feasible. The vaccine would be based on the M2 protein of influenza A viruses. As yet application of such a universal vaccine seems to be far away, however, since so far only pre-clinical data in a mouse model have been generated. Furthermore, the M2 protein is only present in influenza A viruses and is known to be a minor viral antigen. In addition it may become more variable when it is exposed to immunity in the vaccinated population.
authors.affiliation: Nationaal Influenza Centrum van de Wereldgezondheidsorganisatie, Erasmus Universiteit, afd. Virologie, Rotterdam.
authors.forename: G F
authors.initials: GF
authors.lastname: Rimmelzwaan
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D005544:Forecasting; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control*; D051379:Mice; D014763:Viral Matrix Proteins / Q000276:immunology; D000086082:Viroporin Proteins
chemical_list: D000956:Antigens, Viral; D007252:Influenza Vaccines; D014763:Viral Matrix Proteins; C031540:M-protein, influenza virus; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins
vernacular_title: Universeel influenzavaccin nog ver weg.