Increased sensitivity of prediabetic nonobese diabetic mouse to the behavioral effects of IL-1.
The nonobese diabetic (NOD) mouse is a model of spontaneous insulin-dependent diabetes mellitus (IDDM) or type I diabetes. In humans, and in animal models of IDDM, the progression of the disease is modulated by various environmental factors, particularly infectious agents. Interleukin-1 (IL-1) plays a pivotal role in the development of IDDM, and modulation of its synthesis may be a mechanism by which environmental modulation of disease progression occurs. Since various alterations at the level of the gene, number, and sensitivity of IL-1 receptors have been described in different animal models of autoimmune disease, we investigated, in the prediabetic NOD mouse, the presence of IL-1 receptors and their functional behavioral characteristics. Here we present evidence that prediabetic NOD mice exhibit a normal distribution and density of functional brain IL-1 receptors, but are more sensitive to the behavioral effects of IL-1 than the control ICR strain.
Bluth
Institut François Magendie, Rue Camille Saint Saëns, Bordeaux cedex, 33077, France.
Jafarian-Tehrani
M
M
Michaud
B
B
Haour
F
F
Dantzer
R
R
Homo-Delarche
F
F
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D005106:Exploratory Behavior / Q000187:drug effects; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016688:Mice, Inbred NOD; D009043:Motor Activity / Q000187:drug effects; D011236:Prediabetic State / Q000235:genetics / Q000523:psychology*; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D012919:Social Behavior
D004731:Endotoxins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; C044101:endotoxin, Escherichia coli