NG2 expression in MLL rearranged acute myeloid leukaemia is restricted to monoblastic cases.
Expression of NG2 has been reported in the majority of paediatric acute leukaemia (AL) cases with MLL rearrangement. We demonstrated 7. 1 positivity in 2/3 paediatric and 4/11 adult MLL rearranged acute myeloid leukaemia (AML) but in 0/28 adult AML without MLL rearrangement, thus extending the 100% specificity to adult cases. Positivity correlated with stage of maturation arrest since it was found in 0/6 immature AML but in 6/8 monoblastic cases. These data demonstrate that, if NG2 expression in AL is the (in)direct result of MLL rearrangement, such activation is restricted to a monoblastic population in AML. They also have practical implications for NG2 diagnostic screening strategies.
Mauvieux
L
L
Haematology and Cytogenetics, Hôpital Necker-Enfants Malades, Paris, France.
Delabesse
E
E
Bourquelot
P
P
Radford-Weiss
I
I
Bennaceur
A
A
Flandrin
G
G
Valensi
F
F
MacIntyre
E A
EA
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000235:genetics* / Q000378:metabolism; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D051788:Myeloid-Lymphoid Leukemia Protein; D011509:Proteoglycans / Q000235:genetics* / Q000378:metabolism; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014407:Tumor Cells, Cultured; D000099216:Chondroitin Sulfate Proteoglycan 4
D000941:Antigens; D004268:DNA-Binding Proteins; D011495:Histone-Lysine N-Methyltransferase; D051788:Myeloid-Lymphoid Leukemia Protein; D011509:Proteoglycans; D014157:Transcription Factors; D000099216:Chondroitin Sulfate Proteoglycan 4; C497422:KMT2A protein, human