Continuous infusion of von Willebrand factor and factor VIII after elective heart surgery in a 12-year-old girl with von Willebrand disease type 3.
The continuous infusion of von Willebrand factor (VWF) in a 12-year-old girl with type 3 von Willebrand disease is described. The patient had elective heart surgery with cardiopulmonary bypass for closure of her atrial septum defect. The surgical procedure lasted 3 h. A presurgical bolus followed by a postoperative continuous infusion of factor VIII/VWF concentrates was administered. During the continuous infusion of clotting factors, stable plasma levels of hemostasis and avoidance of dangerously low levels of factor concentrates were achieved. No peri- or postsurgical complications occurred. Continuous infusion of clotting factors allows constant and hemostatic factor concentrations to be maintained with the possibility of dose titration and adjustment.
Kühne
T
T
Division of Oncology/Haematology, University Children's Hospital, Basel, Switzerland. Thomas.Kuehne@hin.ch
Imbach
P
P
Marbet
G A
GA
Caliezi
C
C
Devay
J
J
D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002648:Child; D003241:Consanguinity; D017558:Elective Surgical Procedures; D005169:Factor VIII / Q000008:administration & dosage*; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D014842:von Willebrand Diseases / Q000188:drug therapy* / Q000601:surgery*; D014841:von Willebrand Factor / Q000008:administration & dosage*
D014841:von Willebrand Factor; D005169:Factor VIII