title: TRANSFAC: an integrated system for gene expression regulation.
abstract: TRANSFAC is a database on transcription factors, their genomic binding sites and DNA-binding profiles (http://transfac.gbf.de/TRANSFAC/). Its content has been enhanced, in particular by information about training sequences used for the construction of nucleotide matrices as well as by data on plant sites and factors. Moreover, TRANSFAC has been extended by two new modules: PathoDB provides data on pathologically relevant mutations in regulatory regions and transcription factor genes, whereas S/MARt DB compiles features of scaffold/matrix attached regions (S/MARs) and the proteins binding to them. Additionally, the databases TRANSPATH, about signal transduction, and CYTOMER, about organs and cell types, have been extended and are increasingly integrated with the TRANSFAC data sources.
authors.affiliation: Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany. ewi@gbf.de
authors.forename: E
authors.initials: E
authors.lastname: Wingender
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: R
authors.initials: R
authors.lastname: Hehl
authors.forename: H
authors.initials: H
authors.lastname: Karas
authors.forename: I
authors.initials: I
authors.lastname: Liebich
authors.forename: V
authors.initials: V
authors.lastname: Matys
authors.forename: T
authors.initials: T
authors.lastname: Meinhardt
authors.forename: M
authors.initials: M
authors.lastname: Prüss
authors.forename: I
authors.initials: I
authors.lastname: Reuter
authors.forename: F
authors.initials: F
authors.lastname: Schacherer
mesh_terms: D003628:Database Management Systems; D016208:Databases, Factual; D005786:Gene Expression Regulation; D020407:Internet; D014157:Transcription Factors / Q000145:classification / Q000378:metabolism*
chemical_list: D014157:Transcription Factors