title: Bioavailability of aciclovir after oral administration of aciclovir and its prodrug valaciclovir to patients with leukopenia after chemotherapy.
abstract: The median bioavailabilities of aciclovir after administration of aciclovir and its prodrug valaciclovir were 21.5 and 70.1%, respectively, in 12 patients with malignant hematological diseases with leukopenia after chemotherapy. The interindividual variations of the bioavailability were 48.5 and 21.0% after administration of aciclovir and valaciclovir, respectively. Neither the bioavailability nor the interindividual variation of area under the concentration-time curve of oral aciclovir or valaciclovir differed from that reported in healthy volunteers.
authors.affiliation: Department of Medicine, Division of Hematology, Karolinska Hospital, SE-171 76 Stockholm, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Steingrimsdottir
authors.forename: A
authors.initials: A
authors.lastname: Gruber
authors.forename: C
authors.initials: C
authors.lastname: Palm
authors.forename: G
authors.initials: G
authors.lastname: Grimfors
authors.forename: M
authors.initials: M
authors.lastname: Kalin
authors.forename: S
authors.initials: S
authors.lastname: Eksborg
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D006801:Humans; D007970:Leukopenia / Q000188:drug therapy / Q000378:metabolism*; D011355:Prodrugs / Q000493:pharmacokinetics*; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D000998:Antiviral Agents; D011355:Prodrugs; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir