title: Post graft development of short children treated with growth hormone before kidney graft.
abstract: Sixteen prepubertal patients with chronic renal failure (CRF) were given daily recombinant human growth hormone (rhGH) treatment (1.2 IU/kg per week) for 2.6+/-1.6 years until kidney transplant. Therapy was then discontinued and the patients followed for a further 3. 5+/-1.4 years. During treatment, mean height increased from -3.0+/-0. 9 standard deviation score (SDS) to -1.9+/-1.4 SDS (P<0.001) at the time of transplantation, corresponding to a mean height gain of +1. 2+/-0.9 SDS. After discontinuation of rhGH therapy, prepubertal children continued a partial catch-up growth with a height gain of +0.5+/-0.8 SDS for the follow-up period. Conversely, negative changes of height were observed in pubertal transplanted children: -0.5+/-0.4 SDS in patients grafted at early stages of puberty (P2-P3) and -0.15+/-0.9 SDS in patients grafted at late stages of puberty (P4-P5). These data confirmed the benefit of rhGH therapy in CRF patients. Nevertheless, only early initiation of rhGH treatment led some of these patients to their target height at transplantation, thus preserving their potential growth. Reinitiation of rhGH therapy after transplantation should be considered in order to complete catch-up growth to target height in prepubertal children.
authors.affiliation: Pediatric Endocrinology and Diabetology Unit, Robert Debré Hospital, 48 Boulevard Sérurier, F-15019 Paris, France. dominique.simon@rdb.ap-hop-paris.fr
authors.forename: D
authors.initials: D
authors.lastname: Simon
authors.forename: M
authors.initials: M
authors.lastname: Rosilio
authors.forename: A
authors.initials: A
authors.lastname: Maisin
authors.forename: M
authors.initials: M
authors.lastname: Remesy
authors.forename: V
authors.initials: V
authors.lastname: Baudouin
authors.forename: C
authors.initials: C
authors.lastname: Loirat
authors.forename: P
authors.initials: P
authors.lastname: Czernichow
mesh_terms: D000367:Age Factors; D001827:Body Height / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003401:Creatine / Q000097:blood; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D019382:Human Growth Hormone; D003401:Creatine; D011241:Prednisone