Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway.
At present, little is known about the pathogenesis of acute virus-induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.
Puglielli
M T
MT
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Browning
J L
JL
Brewer
A W
AW
Schreiber
R D
RD
Shieh
W J
WJ
Altman
J D
JD
Oldstone
M B
MB
Zaki
S R
SR
Ahmed
R
R
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008216:Lymphocytic Choriomeningitis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D053259:Lymphotoxin beta Receptor; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors*; D012131:Respiratory Insufficiency / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012772:Shock, Septic / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction; D013997:Time Factors
D000911:Antibodies, Monoclonal; C505697:LTBR protein, human; C505699:Ltbr protein, mouse; D053259:Lymphotoxin beta Receptor; D018124:Receptors, Tumor Necrosis Factor