title: Recovery of visual field function in the optic neuritis treatment trial.
abstract: OBJECTIVE
  To assess the pattern of recovery of the visual field of patients with optic neuritis and to determine whether all affected portions of the visual field recover similarly or certain portions of the visual field have greater recovery.
  
  
  METHODS
  We reviewed the Humphrey Visual Field (Allergan-Humphrey Inc, San Leandro, California) data from the initial and 6-month examination for the involved and fellow eyes of patients enrolled in the Optic Neuritis Treatment Trial (ONTT). The average threshold for each patient was calculated for the entire tested field and for locations within concentric rings having a radius 3, 9, 15, 21, and 27 degrees from fixation. The absolute amount of improvement and percentage improvement in average threshold between entry and the 6-month follow-up examination were determined for each patient. These measurements were compared within the concentric rings to assess patterns of recovery.
  
  
  RESULTS
  Patients with localized defects recovered 86%+/-20% of their initial defect in average threshold, whereas those having diffuse defects recovered an average of 85%+/-23%. The area about fixation had the greatest relative recovery of threshold (87%+/-21% at 3 degrees); the relative recovery decreased with increasing eccentricity from fixation (P<.01).
  
  
  CONCLUSIONS
  Patients with optic neuritis have a marked return of visual field function that does not appear to differ between patients with diffuse or localized field defects. The reduced redundancy of axons in the periphery of the field compared with near fixation may be responsible for the greater relative recovery of threshold near fixation.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Fang
authors.forename: R H
authors.initials: RH
authors.lastname: Lin
authors.forename: S P
authors.initials: SP
authors.lastname: Donahue
mesh_terms: D005403:Fixation, Ocular; D006801:Humans; D009902:Optic Neuritis / Q000188:drug therapy* / Q000503:physiopathology*; D020127:Recovery of Function; D012684:Sensory Thresholds; D014794:Visual Fields