title: Trovafloxacin concentrations in airway fluids of patients with severe community-acquired pneumonia.
abstract: The penetration of trovafloxacin (TVA), 200 mg once daily, into the airways of 17 patients with severe pneumonia was studied. The mean (standard deviations are given in parentheses) steady-state TVA concentrations, 2 h after the last intake, were 3.1 (0.3) mg/liter in induced sputum (n = 8), 3.2 (1.1) mg/liter in bronchial secretions (n = 9), 3.2 (0.9) mg/liter in bronchoalveolar lavage fluid (n = 10), and 4.9 (1.4) mg/liter in epithelial lining fluid (n = 11).
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, University Hospital Ghent, 185 De Pintelaan, B9000 Ghent, Belgium. renaat.peleman@rug.ac.be
authors.forename: R A
authors.initials: RA
authors.lastname: Peleman
authors.forename: V
authors.initials: V
authors.lastname: Van De Velde
authors.forename: P R
authors.initials: PR
authors.lastname: Germonpré
authors.forename: C
authors.initials: C
authors.lastname: Fleurinck
authors.forename: M T
authors.initials: MT
authors.lastname: Rosseel
authors.forename: R A
authors.initials: RA
authors.lastname: Pauwels
mesh_terms: D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy*; D013183:Sputum / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin