Inactivation of gene expression using ribonuclease P and external guide sequences.
Guerrier-Takada
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Altman
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D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D015195:Drug Design; D004722:Endoribonucleases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins; D005786:Gene Expression Regulation / Q000187:drug effects*; D005822:Genetic Vectors; D006801:Humans; D008322:Mammals; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016133:Polymerase Chain Reaction / Q000379:methods; D011401:Promoter Regions, Genetic; D012322:RNA Precursors / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D012329:RNA, Bacterial / Q000235:genetics; D016337:RNA, Catalytic / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012342:RNA, Small Nuclear / Q000235:genetics; D012365:RNA, Transfer, Tyr / Q000235:genetics; D043262:Ribonuclease P; D013379:Substrate Specificity
D029968:Escherichia coli Proteins; D020319:Oligodeoxyribonucleotides, Antisense; D012322:RNA Precursors; D012329:RNA, Bacterial; D016337:RNA, Catalytic; D012333:RNA, Messenger; D012342:RNA, Small Nuclear; D012365:RNA, Transfer, Tyr; D004722:Endoribonucleases; C468368:RPP14 protein, human; D043262:Ribonuclease P; C470865:ribonuclease P, E coli