title: [The effect of cytochrome c on the myocardium during reperfusion].
abstract: Experimental and clinical trials have shown high effectiveness of cytochrome c (0.5 mg/kg) in prevention of reperfusion myocardial disorders in cardiosurgical patients. Cytochrome c inhibits development of myocardial ischemic contracture, depression of coronary circulation, activation of lipid peroxidation. It reduces myocardial consumption of oxygen and promotes earlier restoration of fatty acids metabolism under lower glucose consumption by the heart muscle. By correction of myocardial metabolism, the drug suppresses fermentemia in early reperfusion.
authors.forename: G A
authors.initials: GA
authors.lastname: Boiarinov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Iakovlev
authors.forename: S A
authors.initials: SA
authors.lastname: Teziaeva
authors.forename: I V
authors.initials: IV
authors.lastname: Mukhina
authors.forename: L V
authors.initials: LV
authors.lastname: Boiarinova
mesh_terms: D000818:Animals; D002317:Cardiovascular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003574:Cytochrome c Group / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011300:Preoperative Care; D051381:Rats; D013997:Time Factors
chemical_list: D002317:Cardiovascular Agents; D003574:Cytochrome c Group; D005609:Free Radicals
vernacular_title: Vliianie tsitokhroma c na miokard vo vremia reperfuzii.