Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine.
Bernal
M L
ML
Department of Pharmacology and Physiology, University of Zaragoza, Domingo Miral, Spain.
Sinues
B
B
Johansson
I
I
McLellan
R A
RA
Wennerholm
A
A
Dahl
M L
ML
Ingelman-Sundberg
M
M
Bertilsson
L
L
D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics* / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D020440:Gene Duplication; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D010641:Phenotype; D013030:Spain
D019389:Cytochrome P-450 CYP2D6; D003647:Debrisoquin