Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function.
Airway S-nitrosothiols (SNOs) are naturally occurring bronchodilators. SNOs, nitrate, and nitrite were measured in bronchoalveolar lavage fluid of 23 patients with cystic fibrosis (CF) and mild pulmonary disease (aged 6-16 years) and 13 healthy children (aged 8-15 years). Concentrations of SNOs were decreased in the lower airways of patients with CF and mild pulmonary disease (median, range: 0, 0-320 nmol/L vs 80, 0-970 nmol/L) despite normal levels of the inert nitric oxide metabolites nitrate and nitrite (mean +/- SEM: 3.7 +/- 0.5 micromol/L vs 4.8 +/- 0.9 micromol/L). S-nitrosolation- mediated bioreactivities may be impaired by depletion of the CF airway SNO reservoir.
Grasemann
H
H
Children's Hospital, University of Essen, Essen, Germany.
Gaston
B
B
Fang
K
K
Paul
K
K
Ratjen
F
F
D000293:Adolescent; D001980:Bronchi / Q000737:chemistry*; D001992:Bronchoalveolar Lavage Fluid; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008623:Mercaptoethanol; D009603:Nitroso Compounds / Q000032:analysis*; D012129:Respiratory Function Tests; D026403:S-Nitrosothiols
D009603:Nitroso Compounds; D026403:S-Nitrosothiols; D008623:Mercaptoethanol; C032635:S-nitrosomercaptoethanol