title: Interleukin-1 haplotype and periodontal disease progression following therapy.
abstract: The purpose of this study was to assess the prognostic value of the IL-1 haplotype on the progression of periodontal disease following therapy. 48 adult patients with untreated periodontitis harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full-mouth scaling alone (control) or in combination with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). All patients received supportive periodontal therapy at 3 to 6 months intervals. In 33 patients, lymphocyte DNA was analyzed for polymorphism in the IL-1A gene at position -889 and IL-1B gene at position +3953. Overall, 16 of 33 patients (7 of 17 test and 9 of 16 control) carried the IL-1 haplotype. 2 years following initial periodontal therapy, no differences in the survival rates of sites or teeth not exhibiting probing attachment loss of 2 mm or more compared to baseline, were found between patients who tested positive (85% sites, 53% teeth) and patients who tested negative (89% sites, 56% teeth) for the IL-1 haplotype. The results indicated that the IL-1 haplotype may be of limited value for the prognosis of periodontal disease progression following non-surgical periodontal therapy.
authors.affiliation: Department of Periodontology, Julius Maximilians University, Würzburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ehmke
authors.forename: W
authors.initials: W
authors.lastname: Kress
authors.forename: H
authors.initials: H
authors.lastname: Karch
authors.forename: T
authors.initials: T
authors.lastname: Grimm
authors.forename: B
authors.initials: B
authors.lastname: Klaiber
authors.forename: T F
authors.initials: TF
authors.lastname: Flemmig
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D003131:Combined Modality Therapy; D018450:Disease Progression; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood / Q000235:genetics* / Q000382:microbiology / Q000628:therapy; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D007375:Interleukin-1