[Oncogenes and tumor suppressor genes as a tool for clinical diagnosis of solid tumors].
Over the past few years, numerous clinical studies have examined genetic technology to detect physical alterations of genes, such as mutations, translocations and amplification of oncogenes, deletion of tumor suppressor genes, the presence of oncogenic viruses, and the expression of genes specific to cancer tissues. The ability to identify individuals at high risk for cancer holds the promise of improved prevention and early diagnosis of cancers. The goal of genetic diagnosis in cancer is to provide information on abnormal oncogenes and tumor suppressor genes using recent molecular biology techniques. We introduced a highly sensitive method of detecting micrometastasis using PCR in prostate cancer, and strategies for guidelines in clinical diagnosis.
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Department of Molecular Diagnostics, Tohoku University, School of Medicine, Sendai.
D016153:Genes, Suppressor; D005821:Genetic Techniques; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D009857:Oncogenes