title: Case report. Osteomyelitis caused by high resistant Candida guilliermondii.
abstract: We describe a case of a 57-year-old patient with osteomyelitis at a finger of his right hand caused by Candida guilliermondii. The strains isolated were highly resistant to fluconazole and itraconazole. Using the three methods, microdilution, agardilation and E-test, the highest minimum inhibitory concentrations (MICs) amounted to > 256 micrograms ml-1 for fluconazole and > 32 micrograms ml-1 for itraconazole. To our knowledge, this is the first time such high values have been described for C. guilliermondii. They correlated with the therapeutic non-response to a triazole therapy in our patient. The patient was cured by partial amputation of the affected finger.
authors.forename: H J
authors.initials: HJ
authors.lastname: Tietz
authors.forename: V
authors.initials: V
authors.lastname: Czaika
authors.forename: W
authors.initials: W
authors.lastname: Sterry
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D005385:Fingers; D015725:Fluconazole / Q000494:pharmacology; D006229:Hand Dermatoses / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole