title: When the body and appendage of the left atrium disagree: "Focal" atrial fibrillation-implications for atrial thrombus formation and risk of thromboembolism.
abstract: A case is presented of a man who had 5 hours of atrial fibrillation followed by spontaneous conversion and maintained sinus rhythm that persisted as shown by surface electrocardiography. Transesophageal echocardiography performed 24 hours after electrocardiographic conversion documented an atrial fibrillation pattern within the left atrial appendage, with a normal sinus Doppler pattern in the body of the left atrium. This apparent regional discrepancy in atrial function may partially explain the increased risk for "late" thromboembolism among patients with atrial fibrillation who appear to be successfully converted with sustained sinus rhythm.
authors.affiliation: Charles A. Dana Research Institute and the Harvard Thorndike Laboratory of the Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
authors.forename: T B
authors.initials: TB
authors.lastname: Seto
authors.forename: W A
authors.initials: WA
authors.lastname: Buchholz
authors.forename: P S
authors.initials: PS
authors.lastname: Douglas
authors.forename: W J
authors.initials: WJ
authors.lastname: Manning
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use; D020517:Atrial Appendage / Q000000981:diagnostic imaging; D001281:Atrial Fibrillation / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D001783:Blood Flow Velocity; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D004562:Electrocardiography; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006339:Heart Rate; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011342:Procainamide / Q000008:administration & dosage / Q000627:therapeutic use; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000889:Anti-Arrhythmia Agents; D011342:Procainamide