title: Prolongation of rat heart allograft survival with K(+)ATP-dependent channel modulators.
abstract: Controversies exist regarding the immunoregulatory properties of K(+) ATP channel modulators. We investigated the effects of aprikalim, a K(+) ATP-dependent channels activator, and glibenclamide and gliclazide, two inhibitors of K(+) ATP-dependent channels, on the prolongation of heart allograft survival in the rat. Nine groups (n >/= 5) were involved in this study with the Brown-Norway to Lewis rat combination treated with aprikalim, glibenclamide, gliclazide, and/or cyclosporine. The results indicate that modulators of K(+) ATP-dependent channels can improve the survival of rat heart allograft without interfering with the immunosuppressive properties of cyclosporine.
authors.affiliation: Laboratory of Experimental Surgery, Research Center of CHUM, Notre-Dame Hospital, University of Montreal, Montreal, Quebec, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Rheaume
authors.forename: L
authors.initials: L
authors.lastname: Dumont
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.forename: D
authors.initials: D
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Qi
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D006085:Graft Survival / Q000502:physiology*; D016027:Heart Transplantation / Q000502:physiology*; D008297:Male; D010847:Picolines / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology*; D011714:Pyrans / Q000494:pharmacology; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D010847:Picolines; D015221:Potassium Channels; D011714:Pyrans; D014665:Vasodilator Agents; C061043:aprikalim